Sample records for human exploration project
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Furniss, Dominic; Curzon, Paul; Blandford, Ann
2018-06-01
Organisational competence in Human Factors and UX (user experience) has not been looked at before despite its relevance to project success. We define organisational competence as the collective competence of the individuals, bringing together their complementary abilities to deliver an outcome that is typically more than the sum of its parts. Twenty-two UX and Human Factors practitioners were interviewed about their project work in two contrasting domains: web design and safety-critical systems to explore organisational competences. Through doing a FRAM analysis, 29 functions and 6 main areas of competences were identified: the central project process; the process of learning about the problem; maintaining and developing client relations; staff development; evolving practices; and the management of documentation for audit and quality control. These dynamic and situated competences form a web of interactions. Managing competences is essential for project success. Implications for managing careers, project tactics and organisational strategy are discussed. Practitioner Summary: Organisational competences impact how routine and non-routine project work is performed, but these have received little attention in the literature. Six key areas of competences in Human Factors and UX project work were identified from practitioner interviews. Managing combinations of adaptive competences is important for developing careers, project tactics and organisational strategies.
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Nguyen, Hung D.; Steele, Gynelle C.
2017-01-01
This report is intended to help NASA program and project managers incorporate Small Business Innovation Research Small Business Technology Transfer (SBIR/STTR) technologies into NASA Human Exploration and Operations Mission Directorate (HEOMD) projects. Other Government and commercial projects managers can also find this useful. Space Transportation; Life Support and Habitation Systems; Extra-Vehicular Activity; High EfficiencySpace Power; Human Exploration and Operations Mission,
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The development of the human exploration demonstration project (HEDP), a planetary systems testbed
Chevers, Edward S.; Korsmeyer, David J.
1993-01-01
The Human Exploration Demonstration Project (HEDP) is an ongoing task at the National Aeronautics and Space Administration's Ames Research Center to address the advanced technology requirements necessary to implement an integrated working and living environment for a planetary surface habitat. The integrated environment will consist of life support systems, physiological monitoring of project crew, a virtual environment workstation, and centralized data acquisition and habitat systems health monitoring. There will be several robotic systems on a simulated planetary landscape external to the habitat environment to provide representative work loads for the crew. This paper describes the status of the HEDP after one year, the major facilities composing the HEDP, the project's role as an Ames Research Center testbed, and the types of demonstration scenarios that will be run to showcase the technologies.
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Human-Robot Planetary Exploration Teams
Tyree, Kimberly
2004-01-01
The EVA Robotic Assistant (ERA) project at NASA Johnson Space Center studies human-robot interaction and robotic assistance for future human planetary exploration. Over the past four years, the ERA project has been performing field tests with one or more four-wheeled robotic platforms and one or more space-suited humans. These tests have provided experience in how robots can assist humans, how robots and humans can communicate in remote environments, and what combination of humans and robots works best for different scenarios. The most efficient way to understand what tasks human explorers will actually perform, and how robots can best assist them, is to have human explorers and scientists go and explore in an outdoor, planetary-relevant environment, with robots to demonstrate what they are capable of, and roboticists to observe the results. It can be difficult to have a human expert itemize all the needed tasks required for exploration while sitting in a lab: humans do not always remember all the details, and experts in one arena may not even recognize that the lower level tasks they take for granted may be essential for a roboticist to know about. Field tests thus create conditions that more accurately reveal missing components and invalid assumptions, as well as allow tests and comparisons of new approaches and demonstrations of working systems. We have performed field tests in our local rock yard, in several locations in the Arizona desert, and in the Utah desert. We have tested multiple exploration scenarios, such as geological traverses, cable or solar panel deployments, and science instrument deployments. The configuration of our robot can be changed, based on what equipment is needed for a given scenario, and the sensor mast can even be placed on one of two robot bases, each with different motion capabilities. The software architecture of our robot is also designed to be as modular as possible, to allow for hardware and configuration changes. Two focus
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Barta, Daniel J.
2012-01-01
Next Generation Life Support (NGLS) is one of several technology development projects sponsored by the National Aeronautics and Space Administration s Game Changing Development Program. NGLS is developing life support technologies (including water recovery, and space suit life support technologies) needed for humans to live and work productively in space. NGLS has three project tasks: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, and Alternative Water Processing. The selected technologies within each of these areas are focused on increasing affordability, reliability, and vehicle self sufficiency while decreasing mass and enabling long duration exploration. The RCA and VOR tasks are directed at key technology needs for the Portable Life Support System (PLSS) for an Exploration Extravehicular Mobility Unit (EMU), with focus on prototyping and integrated testing. The focus of the Rapid Cycle Amine (RCA) swing-bed ventilation task is to provide integrated carbon dioxide removal and humidity control that can be regenerated in real time during an EVA. The Variable Oxygen Regulator technology will significantly increase the number of pressure settings available to the space suit. Current spacesuit pressure regulators are limited to only two settings while the adjustability of the advanced regulator will be nearly continuous. The Alternative Water Processor efforts will result in the development of a system capable of recycling wastewater from sources expected in future exploration missions, including hygiene and laundry water, based on natural biological processes and membrane-based post treatment. The technologies will support a capability-driven architecture for extending human presence beyond low Earth orbit to potential destinations such as the Moon, near Earth asteroids and Mars.
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Heldmann, J. L.; Lim, D.S.S.; Hughes, S.; Nawotniak, S. Kobs; Garry, B.; Sears, D.; Neish, C.; Osinski, G. R.; Hodges, K.; Downs, M.;
2016-01-01
NASA's FINESSE (Field Investigations to Enable Solar System Science and Exploration) project was selected as a research team by NASA's Solar System Exploration Research Virtual Institute (SSERVI). SSERVI is a joint Institute supported by NASA's Science Mission Directorate (SMD) and Human Exploration and Operations Mission Directorate (HEOMD). As such, FINESSE is focused on a science and exploration field-based research program to generate strategic knowledge in preparation for human and robotic exploration of other planetary bodies including our Moon, Mars moons Phobos and Deimos, and near-Earth asteroids. FINESSE embodies the philosophy that "science enables exploration and exploration enables science".
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The Human Genome Diversity (HGD) Project. Summary document
Energy Technology Data Exchange (ETDEWEB)
NONE
1993-12-31
In 1991 a group of human geneticists and molecular biologists proposed to the scientific community that a world wide survey be undertaken of variation in the human genome. To aid their considerations, the committee therefore decided to hold a small series of international workshops to explore the major scientific issues involved. The intention was to define a framework for the project which could provide a basis for much wider and more detailed discussion and planning--it was recognized that the successful implementation of the proposed project, which has come to be known as the Human Genome Diversity (HGD) Project, would not only involve scientists but also various national and international non-scientific groups all of which should contribute to the project`s development. The international HGD workshop held in Sardinia in September 1993 was the last in the initial series of planning workshops. As such it not only explored new ground but also pulled together into a more coherent form much of the formal and informal discussion that had taken place in the preceding two years. This report presents the deliberations of the Sardinia workshop within a consideration of the overall development of the HGD Project to date.
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Geospace exploration project: Arase (ERG)
Miyoshi, Y.; Kasaba, Y.; Shinohara, I.; Takashima, T.; Asamura, K.; Matsumoto, H.; Higashio, N.; Mitani, T.; Kasahara, S.; Yokota, S.; Wang, S.; Kazama, Y.; Kasahara, Y.; Yagitani, S.; Matsuoka, A.; Kojima, H.; Katoh, Y.; Shiokawa, K.; Seki, K.; Fujimoto, M.; Ono, T.; ERG project Group
2017-06-01
The ERG (Exploration of energization and Radiation in Geospace) is Japanese geospace exploration project. The project focuses on relativistic electron acceleration mechanism of the outer belt and dynamics of space storms in the context of the cross-energy coupling via wave-particle interactions. The project consists of the satellite observation team, the ground-based network observation team, and integrated-data analysis/simulation team. The satellite was launched on December 20 2016 and has been nicknamed, “Arase”. This paper describes overview of the project and future plan for observations.
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Human Exploration Ethnography of the Haughton-Mars Project, 1998-1999
Clancey, William J.; Swanson, Keith (Technical Monitor)
1999-01-01
During the past two field seasons, July 1988 and 1999, we have conducted research about the field practices of scientists and engineers at Haughton Crater on Devon Island in the Canadian Arctic, with the objective of determining how people will live and work on Mars. This broad investigation of field life and work practice, part of the Haughton-Mars Project lead by Pascal Lee, spans social and cognitive anthropology, psychology, and computer science. Our approach involves systematic observation and description of activities, places, and concepts, constituting an ethnography of field science at Haughton. Our focus is on human behaviors-what people do, where, when, with whom, and why. By locating behavior in time and place-in contrast with a purely functional or "task oriented" description of work-we find patterns constituting the choreography of interaction between people, their habitat, and their tools. As such, we view the exploration process in terms of a total system comprising a social organization, facilities, terrain/climate, personal identities, artifacts, and computer tools. Because we are computer scientists seeking to develop new kinds of tools for living and working on Mars, we focus on the existing representational tools (such as documents and measuring devices), learning and improvization (such as use of the internet or informal assistance), and prototype computational systems brought to the field. Our research is based on partnership, by which field scientists and engineers actively contribute to our findings, just as we participate in their work and life.
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Exploration Medical System Demonstration (EMSD) Project
Chin, Duane
2012-01-01
The Exploration Medical System Demonstration (EMSD) is a project under the Exploration Medical Capability (ExMC) element managed by the Human Research Program (HRP). The vision for the EMSD is to utilize ISS as a test bed to show that several medical technologies needed for an exploration mission and medical informatics tools for managing evidence and decision making can be integrated into a single system and used by the on-orbit crew in an efficient and meaningful manner. Objectives: a) Reduce and even possibly eliminate the time required for on-orbit crew and ground personnel (which include Surgeon, Biomedical Engineer (BME) Flight Controller, and Medical Operations Data Specialist) to access and move medical data from one application to another. b) Demonstrate that the on-orbit crew has the ability to access medical data/information using an intuitive and crew-friendly software solution to assist/aid in the treatment of a medical condition. c) Develop a common data management framework and architecture that can be ubiquitously used to automate repetitive data collection, management, and communications tasks for all crew health and life sciences activities.
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Think Big! The Human Condition Project
Metcalfe, Gareth
2014-01-01
How can educators provide children with a genuine experience of carrying out an extended scientific investigation? And can teachers change the perception of what it means to be a scientist? These were key questions that lay behind "The Human Condition" project, an initiative funded by the Primary Science Teaching Trust to explore a new…
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Human Exploration Science Office (KX) Overview
Calhoun, Tracy A.
2014-01-01
The Human Exploration Science Office supports human spaceflight, conducts research, and develops technology in the areas of space orbital debris, hypervelocity impact technology, image science and analysis, remote sensing, imagery integration, and human and robotic exploration science. NASA's Orbital Debris Program Office (ODPO) resides in the Human Exploration Science Office. ODPO provides leadership in orbital debris research and the development of national and international space policy on orbital debris. The office is recognized internationally for its measurement and modeling of the debris environment. It takes the lead in developing technical consensus across U.S. agencies and other space agencies on debris mitigation measures to protect users of the orbital environment. The Hypervelocity Impact Technology (HVIT) project evaluates the risks to spacecraft posed by micrometeoroid and orbital debris (MMOD). HVIT facilities at JSC and White Sands Test Facility (WSTF) use light gas guns, diagnostic tools, and high-speed imagery to quantify the response of spacecraft materials to MMOD impacts. Impact tests, with debris environment data provided by ODPO, are used by HVIT to predict risks to NASA and commercial spacecraft. HVIT directly serves NASA crew safety with MMOD risk assessments for each crewed mission and research into advanced shielding design for future missions. The Image Science and Analysis Group (ISAG) supports the International Space Station (ISS) and commercial spaceflight through the design of imagery acquisition schemes (ground- and vehicle-based) and imagery analyses for vehicle performance assessments and mission anomaly resolution. ISAG assists the Multi-Purpose Crew Vehicle (MPCV) Program in the development of camera systems for the Orion spacecraft that will serve as data sources for flight test objectives that lead to crewed missions. The multi-center Imagery Integration Team is led by the Human Exploration Science Office and provides
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White, Olivier; Clément, Gilles; Fortrat, Jacques-Olivier; Pavy-LeTraon, Anne; Thonnard, Jean-Louis; Blanc, Stéphane; Wuyts, Floris L; Paloski, William H
2016-01-01
The THESEUS project (Towards Human Exploration of Space: a European Strategy), initiated within the seventh Framework Programme by the European Commission, aimed at providing a cross-cutting, life-science-based roadmap for Europe's strategy towards human exploration of long space missions, and its relevance to applications on Earth. This topic was investigated by experts in the field, in the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration. In particular, decades of research have shown that altered gravity impairs neurological responses at large, such as perception, sleep, motor control, and cognitive factors. International experts established a list of key issues that should be addressed in that context and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space.
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Yang, Allen H. J.; Dimiduk, Kathryn; Daniel, Susan
2011-01-01
We present a simplified human alcohol metabolism model for a mass balance team project. Students explore aspects of engineering in biotechnology: designing/modeling biological systems, testing the design/model, evaluating new conditions, and exploring cutting-edge "lab-on-a-chip" research. This project highlights chemical engineering's impact on…
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Overview of the Human Exploration Research Analog (HERA)
Neigut, J.
2015-01-01
In 2013, the Human Research Program at NASA began developing a new confinement analog specifically for conducting research to investigate the effects of confinement on the human system. The HERA (Human Exploration Research Analog) habitat has been used for both 7 and 14 day missions to date to examine and mitigate exploration risks to enable safe, reliable and productive human space exploration. This presentation will describe how the Flight Analogs Project developed the HERA facility and the infrastructure to suit investigator requirements for confinement research and in the process developed a new approach to analog utilization and a new state of the art analog facility. Details regarding HERA operations will be discussed including specifics on the mission simulation utilized for the current 14-day campaign, the specifics of the facility (total volume, overall size, hardware), and the capabilities available to researchers. The overall operational philosophy, mission fidelity including timeline, schedule pressures and cadence, and development and implementation of mission stressors will be presented. Research conducted to date in the HERA has addressed risks associated with behavioral health and performance, human physiology, as well as human factors. This presentation will conclude with a discussion of future research plans for the HERA, including infrastructure improvements and additional research capabilities planned for the upcoming 30-day missions in 2016.
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Exploration Augmentation Module Project
National Aeronautics and Space Administration — The Exploration Augmentation Module (EAM) project goal is to design and deliver a flight module that is to be deployed to Earth-Lunar Distant Retrograde Orbit (DRO)....
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Projecting Drivers of Human Vulnerability under the Shared Socioeconomic Pathways.
Rohat, Guillaume
2018-03-19
The Shared Socioeconomic Pathways (SSPs) are the new set of alternative futures of societal development that inform global and regional climate change research. They have the potential to foster the integration of socioeconomic scenarios within assessments of future climate-related health impacts. To date, such assessments have primarily superimposed climate scenarios on current socioeconomic conditions only. Until now, the few assessments of future health risks that employed the SSPs have focused on future human exposure-i.e., mainly future population patterns-, neglecting future human vulnerability. This paper first explores the research gaps-mainly linked to the paucity of available projections-that explain such a lack of consideration of human vulnerability under the SSPs. It then highlights the need for projections of socioeconomic variables covering the wide range of determinants of human vulnerability, available at relevant spatial and temporal scales, and accounting for local specificities through sectoral and regional extended versions of the global SSPs. Finally, this paper presents two innovative methods of obtaining and computing such socioeconomic projections under the SSPs-namely the scenario matching approach and an approach based on experts' elicitation and correlation analyses-and applies them to the case of Europe. They offer a variety of possibilities for practical application, producing projections at sub-national level of various drivers of human vulnerability such as demographic and social characteristics, urbanization, state of the environment, infrastructure, health status, and living arrangements. Both the innovative approaches presented in this paper and existing methods-such as the spatial disaggregation of existing projections and the use of sectoral models-show great potential to enhance the availability of relevant projections of determinants of human vulnerability. Assessments of future climate-related health impacts should thus rely
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The Human Genome Diversity Project
Energy Technology Data Exchange (ETDEWEB)
Cavalli-Sforza, L. [Stanford Univ., CA (United States)
1994-12-31
The Human Genome Diversity Project (HGD Project) is an international anthropology project that seeks to study the genetic richness of the entire human species. This kind of genetic information can add a unique thread to the tapestry knowledge of humanity. Culture, environment, history, and other factors are often more important, but humanity`s genetic heritage, when analyzed with recent technology, brings another type of evidence for understanding species` past and present. The Project will deepen the understanding of this genetic richness and show both humanity`s diversity and its deep and underlying unity. The HGD Project is still largely in its planning stages, seeking the best ways to reach its goals. The continuing discussions of the Project, throughout the world, should improve the plans for the Project and their implementation. The Project is as global as humanity itself; its implementation will require the kinds of partnerships among different nations and cultures that make the involvement of UNESCO and other international organizations particularly appropriate. The author will briefly discuss the Project`s history, describe the Project, set out the core principles of the Project, and demonstrate how the Project will help combat the scourge of racism.
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Robots and humans: synergy in planetary exploration
Landis, Geoffrey A.
2004-01-01
How will humans and robots cooperate in future planetary exploration? Are humans and robots fundamentally separate modes of exploration, or can humans and robots work together to synergistically explore the solar system? It is proposed that humans and robots can work together in exploring the planets by use of telerobotic operation to expand the function and usefulness of human explorers, and to extend the range of human exploration to hostile environments. Published by Elsevier Ltd.
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Exploring Project Management Education
Steven Nijhuis
2017-01-01
From the article: "The object of this paper is to explore the actual practice in project management education in the Netherlands and compare it to reference institutions and recent literature. A little over 40% of the Higher Education institutions in the Netherlands mentions PM education in
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Directory of Open Access Journals (Sweden)
Sergey Krichevsky
2018-02-01
Full Text Available The 60th anniversary of the Space Age is an important intermediate finishing point on the way of a man and the whole humanity to space. Along with the outstanding achievements, there are a number of challenges and contradictions in space exploration due to the aggravation of the global crisis on Earth, low efficiency and the backlog of space research in the transition to a new technology based reality and clean technologies. Both the international astronautics and the space exploration area nowadays face difficulties in choosing a new paradigm and a development strategy that is becoming even more complicated due to the current unstable and turbulent situation on Earth. The article reveals the optimistic scenario of further space exploration, as well as the methodological and practical aspects of new projects and technologies. The periodization of the Space Age history has been conducted. It has been also proposed a new classification of the “space” phenomenon due to concretizing the concept of “global” in the form of a three-scale structure encompassing the following levels: 1 planetary global; 2 super global; 3 universally global. The notion of “super global space exploration project” has been introduced. The concept of further space exploration is proposed, which includes four interrelated super global projects:1 Earth Protection System from Asteroid and Comet Threat; 2 Moon Exploration; 3 Mars Exploration; 4 Cosmic Humanity. Since the humanity is embarking on the practical implementation of these super global projects, it is urgent to make a transition towards a new technology based order, as well as up-to-date technologies. A couple of ecological projects and space exploration technologies of the 20th and 21st centuries have been exemplified and analyzed. It has been also worked out the list of new environmentally friendly space technologies and projects. The research makes an emphasis upon a great potential of clean and green
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Marov, Mikhail YA.; Duke, Michael B.
1993-01-01
The roles of human and robotic missions in Mars exploration are defined in the context of the short- and long-term Mars programs. In particular, it is noted that the currently implemented and planned missions to Mars can be regarded as robotic precursor missions to human exploration. Attention is given to factors that must be considered in formulating the rationale for human flights to Mars and future human Mars settlements and justifying costly projects.
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Hispanic Vocational Exploration Project. Final Report.
Centro De La Comunidad, Inc., New London, CT.
During its second year, the Hispanic Vocational Exploration Project recruited eighth and ninth grade Hispanic youth for a four-week cycle, after-school, career exploratory program at Southeastern Regional Vocational Technical School, Groton, Connecticut. A series of career education workshops was the other major project activity. Supportive…
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Robotic and Human-Tended Collaborative Drilling Automation for Subsurface Exploration
Glass, Brian; Cannon, Howard; Stoker, Carol; Davis, Kiel
2005-01-01
, either between a robotic drill and humans on Earth, or a human-tended drill and its visiting crew. The Mars Analog Rio Tinto Experiment (MARTE) is a current project that studies and simulates the remote science operations between an automated drill in Spain and a distant, distributed human science team. The Drilling Automation for Mars Exploration (DAME) project, by contrast: is developing and testing standalone automation at a lunar/martian impact crater analog site in Arctic Canada. The drill hardware in both projects is a hardened, evolved version of the Advanced Deep Drill (ADD) developed by Honeybee Robotics for the Mars Subsurface Program. The current ADD is capable of 20m, and the DAME project is developing diagnostic and executive software for hands-off surface operations of the evolved version of this drill. The current drill automation architecture being developed by NASA and tested in 2004-06 at analog sites in the Arctic and Spain will add downhole diagnosis of different strata, bit wear detection, and dynamic replanning capabilities when unexpected failures or drilling conditions are discovered in conjunction with simulated mission operations and remote science planning. The most important determinant of future 1unar and martian drilling automation and staffing requirements will be the actual performance of automated prototype drilling hardware systems in field trials in simulated mission operations. It is difficult to accurately predict the level of automation and human interaction that will be needed for a lunar-deployed drill without first having extensive experience with the robotic control of prototype drill systems under realistic analog field conditions. Drill-specific failure modes and software design flaws will become most apparent at this stage. DAME will develop and test drill automation software and hardware under stressful operating conditions during several planned field campaigns. Initial results from summer 2004 tests show seven identifi
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Social Foundations of Human Space Exploration
Dator, James A
2012-01-01
Social Foundations of Human Space Exploration presents a uniquely human perspective on the quest to explore space and to understand the universe through the lens of the arts, humanities, and social sciences. It considers early stories about the universe in various cultures; recent space fiction; the origins and cultural rationale for the space age; experiences of humans in space and their emerging interactions with robots and artificial intelligence; how humans should treat environments and alien life; and the alternative futures of space exploration and settlement.
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Humane Education Projects Handbook.
Junior League of Ogden, UT.
This handbook was developed to promote interest in humane education and to encourage the adoption of humane education projects. Although specifically designed to assist Junior Leagues in developing such projects, the content should prove valuable to animal welfare organizations, zoos, aquariums, nature centers, and other project-oriented groups…
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DEFF Research Database (Denmark)
Pejtersen, Annelise Mark; Sonnenwald, Diane H.; Buur, Jacob
1997-01-01
the 'Design Explorer' research project whose goal is to specify requirements for an information system that will effectively help design team members from different domains and organizational cultures to locate and utilize diverse information sources and interact more effectively throughout the design process....... The project introduces a new approach to support of design; instead of design guidelines, support is given by creating a transparent information environment in which designers can navigate freely according to their individual preferences. The project is based on a framework that structures the dimensions......, or categories, of domain information which need to be available for a system or product designer/design team in order to determine the characteristics of the artefact, or object of design. These dimensions include information about the different work domains in which the product plays a role during its lifetime...
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Factors of human capital related to project success in health care work units.
Suhonen, Marjo; Paasivaara, Leena
2011-03-01
To explore factors of human capital related to project success that employees expect from nurse managers. Human capital refers to those resources that managers working with projects possess, such as abilities, knowledge and qualities of character. The data were collected by open interviews (n=14) with nurses, public health nurses and nurse managers working in primary health care and a hospital. Data analysis was carried out using qualitative content analysis. The main factors of human capital related to project success proved to be as follows: (1) management of enthusiastic project culture, (2) management of regeneration and (3) management of emotional intelligence. Future research is needed on the kind of means nurse managers use in human capital management in projects and how they see their possibilities in managing human capital. Human capital management skills should be underlined as an important competence area when recruiting a nurse manager. The success of health care projects cannot be improved only through education or by training of nurse managers; in addition, projects need nurse managers who understand workplace spirituality and have high emotional intelligence. © 2011 The Authors. Journal compilation © 2011 Blackwell Publishing Ltd.
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Energy Technology Data Exchange (ETDEWEB)
Block, S. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Cornwall, J. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Dally, W. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Dyson, F. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Fortson, N. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Joyce, G. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Kimble, H. J. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Lewis, N. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Max, C. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Prince, T. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Schwitters, R. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Weinberger, P. [The MITRE Corporation, McLean, VA (US). JASON Program Office; Woodin, W. H. [The MITRE Corporation, McLean, VA (US). JASON Program Office
1998-01-04
The study reviews Department of Energy supported aspects of the United States Human Genome Project, the joint National Institutes of Health/Department of Energy program to characterize all human genetic material, to discover the set of human genes, and to render them accessible for further biological study. The study concentrates on issues of technology, quality assurance/control, and informatics relevant to current effort on the genome project and needs beyond it. Recommendations are presented on areas of the genome program that are of particular interest to and supported by the Department of Energy.
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Astrobiology and the Human Exploration of Mars
Levine, Joel S.; Garvin, James B.; Drake, B. G.; Beaty, David
2010-01-01
In March 2007, the Mars Exploration Program Analysis Group (MEPAG) chartered the Human Exploration of Mars Science Analysis Group (HEM-SAG), co-chaired by J. B. Garvin and J. S. Levine and consisting of about 30 Mars scientists from the U.S. and Europe. HEM-SAG was one of a half dozen teams charted by NASA to consider the human exploration of Mars. Other teams included: Mars Entry, Descent and Landing, Human Health and Performance, Flight and Surface Systems, and Heliospheric/Astrophysics. The results of these Mars teams and the development of an architecture for the human exploration of Mars were summarized in two recent publications: Human Exploration of Mars Design Reference Architecture 5.0, NASA Special Publication-2009-566 (B. G. Drake, Editor), 100 pages, July 2009 and Human Exploration of Mars Design Reference Architecture 5.0, NASA Special Publication-2009-566 Addendum (B. G. Drake, Editor), 406 pages, July 2009. This presentation summarizes the HEM-SAG conclusions on astrobiology and the search for life on Mars by humans.
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Robots and Humans in Planetary Exploration: Working Together?
Landis, Geoffrey A.; Lyons, Valerie (Technical Monitor)
2002-01-01
Today's approach to human-robotic cooperation in planetary exploration focuses on using robotic probes as precursors to human exploration. A large portion of current NASA planetary surface exploration is focussed on Mars, and robotic probes are seen as precursors to human exploration in: Learning about operation and mobility on Mars; Learning about the environment of Mars; Mapping the planet and selecting landing sites for human mission; Demonstration of critical technology; Manufacture fuel before human presence, and emplace elements of human-support infrastructure
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Towards human exploration of space: The THESEUS review series on immunology research priorities
DEFF Research Database (Denmark)
Jean-Pol, Frippiat; Crucian, Brian E; de Quervain, Dominique
2016-01-01
to maintain immune homeostasis under such challenges. In the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration, experts working in the field of space immunology, and related disciplines, established a questionnaire sent...
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International Nuclear Information System (INIS)
Worton, R.
1996-01-01
The Human Genome Project is a massive international research project, costing 3 to 5 billion dollars and expected to take 15 years, which will identify the all the genes in the human genome - i.e. the complete sequence of bases in human DNA. The prize will be the ability to identify genes causing or predisposing to disease, and in some cases the development of gene therapy, but this new knowledge will raise important ethical issues
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de Vries, Jeroen; Abelmann, Leon; Manz, A; Elwenspoek, Michael Curt
2012-01-01
“The Human Document Project‿ is a project which tries to answer all of the questions related to preserving information about the human race for tens of generations of humans to come or maybe even for a future intelligence which can emerge in the coming thousands of years. This document mainly
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Interaction Challenges in Human-Robot Space Exploration
Fong, Terrence; Nourbakhsh, Illah
2005-01-01
In January 2004, NASA established a new, long-term exploration program to fulfill the President's Vision for U.S. Space Exploration. The primary goal of this program is to establish a sustained human presence in space, beginning with robotic missions to the Moon in 2008, followed by extended human expeditions to the Moon as early as 2015. In addition, the program places significant emphasis on the development of joint human-robot systems. A key difference from previous exploration efforts is that future space exploration activities must be sustainable over the long-term. Experience with the space station has shown that cost pressures will keep astronaut teams small. Consequently, care must be taken to extend the effectiveness of these astronauts well beyond their individual human capacity. Thus, in order to reduce human workload, costs, and fatigue-driven error and risk, intelligent robots will have to be an integral part of mission design.
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Applied Nanotechnology for Human Space Exploration
Yowell, Leonard L.
2007-01-01
A viewgraph presentation describing nanotechnology for human space exploration is shown. The topics include: 1) NASA's Strategic Vision; 2) Exploration Architecture; 3) Future Exploration Mission Requirements Cannot be met with Conventional Materials; 4) Nanomaterials: Single Wall Carbon Nanotubes; 5) Applied Nanotechnology at JSC: Fundamentals to Applications; 6) Technology Readiness Levels (TRL); 7) Growth, Modeling, Diagnostics and Production; 8) Characterization: Purity, Dispersion and Consistency; 9) Processing; 10) Nanoelectronics: Enabling Technologies; 11) Applications for Human Space Exploration; 12) Exploration Life Support: Atmosphere Revitalization System; 13) Advanced and Exploration Life Support: Regenerable CO2 Removal; 14) Exploration Life Support: Water Recovery; 15) Advanced Life Support: Water Disinfection/Recovery; 16) Power and Energy: Supercapacitors and Fuel Cells; 17) Nanomaterials for EMI Shielding; 18) Active Radiation Dosimeter; 19) Advanced Thermal Protection System (TPS) Repair; 20) Thermal Radiation and Impact Protection (TRIPS); 21) Nanotechnology: Astronaut Health Management; 22) JSC Nanomaterials Group Collaborations.
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The Digital Humanities as a Humanities Project
Svensson, Patrik
2012-01-01
This article argues that the digital humanities can be seen as a humanities project in a time of significant change in the academy. The background is a number of scholarly, educational and technical challenges, the multiple epistemic traditions linked to the digital humanities, the potential reach of the field across and outside the humanities,…
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Graphical Visualization of Human Exploration Capabilities
Rodgers, Erica M.; Williams-Byrd, Julie; Arney, Dale C.; Simon, Matthew A.; Williams, Phillip A.; Barsoum, Christopher; Cowan, Tyler; Larman, Kevin T.; Hay, Jason; Burg, Alex
2016-01-01
NASA's pioneering space strategy will require advanced capabilities to expand the boundaries of human exploration on the Journey to Mars (J2M). The Evolvable Mars Campaign (EMC) architecture serves as a framework to identify critical capabilities that need to be developed and tested in order to enable a range of human exploration destinations and missions. Agency-wide System Maturation Teams (SMT) are responsible for the maturation of these critical exploration capabilities and help formulate, guide and resolve performance gaps associated with the EMC-identified capabilities. Systems Capability Organization Reporting Engine boards (SCOREboards) were developed to integrate the SMT data sets into cohesive human exploration capability stories that can be used to promote dialog and communicate NASA's exploration investments. Each SCOREboard provides a graphical visualization of SMT capability development needs that enable exploration missions, and presents a comprehensive overview of data that outlines a roadmap of system maturation needs critical for the J2M. SCOREboards are generated by a computer program that extracts data from a main repository, sorts the data based on a tiered data reduction structure, and then plots the data according to specified user inputs. The ability to sort and plot varying data categories provides the flexibility to present specific SCOREboard capability roadmaps based on customer requests. This paper presents the development of the SCOREboard computer program and shows multiple complementary, yet different datasets through a unified format designed to facilitate comparison between datasets. Example SCOREboard capability roadmaps are presented followed by a discussion of how the roadmaps are used to: 1) communicate capability developments and readiness of systems for future missions, and 2) influence the definition of NASA's human exploration investment portfolio through capability-driven processes. The paper concludes with a description
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Human exploration and settlement of Mars - The roles of humans and robots
Duke, Michael B.
1991-01-01
The scientific objectives and strategies for human settlement on Mars are examined in the context of the Space Exploration Initiative (SEI). An integrated strategy for humans and robots in the exploration and settlement of Mars is examined. Such an effort would feature robotic, telerobotic, and human-supervised robotic phases.
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Atmosphere Resource Recovery & Environmental Monitoring for Long Duration Exploration Project
National Aeronautics and Space Administration — The AES Atmosphere Resource Recovery & Environmental Monitoring (ARREM) for Long Duration Exploration Project project is maturing Atmosphere Revitalization...
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Human Factors in Space Exploration
Jones, Patricia M.; Fiedler, Edna
2010-01-01
The exploration of space is one of the most fascinating domains to study from a human factors perspective. Like other complex work domains such as aviation (Pritchett and Kim, 2008), air traffic management (Durso and Manning, 2008), health care (Morrow, North, and Wickens, 2006), homeland security (Cooke and Winner, 2008), and vehicle control (Lee, 2006), space exploration is a large-scale sociotechnical work domain characterized by complexity, dynamism, uncertainty, and risk in real-time operational contexts (Perrow, 1999; Woods et ai, 1994). Nearly the entire gamut of human factors issues - for example, human-automation interaction (Sheridan and Parasuraman, 2006), telerobotics, display and control design (Smith, Bennett, and Stone, 2006), usability, anthropometry (Chaffin, 2008), biomechanics (Marras and Radwin, 2006), safety engineering, emergency operations, maintenance human factors, situation awareness (Tenney and Pew, 2006), crew resource management (Salas et aI., 2006), methods for cognitive work analysis (Bisantz and Roth, 2008) and the like -- are applicable to astronauts, mission control, operational medicine, Space Shuttle manufacturing and assembly operations, and space suit designers as they are in other work domains (e.g., Bloomberg, 2003; Bos et al, 2006; Brooks and Ince, 1992; Casler and Cook, 1999; Jones, 1994; McCurdy et ai, 2006; Neerincx et aI., 2006; Olofinboba and Dorneich, 2005; Patterson, Watts-Perotti and Woods, 1999; Patterson and Woods, 2001; Seagull et ai, 2007; Sierhuis, Clancey and Sims, 2002). The human exploration of space also has unique challenges of particular interest to human factors research and practice. This chapter provides an overview of those issues and reports on sorne of the latest research results as well as the latest challenges still facing the field.
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Exploration Medical System Demonstration Project
Chin, D. A.; McGrath, T. L.; Reyna, B.; Watkins, S. D.
2011-01-01
A near-Earth Asteroid (NEA) mission will present significant new challenges including hazards to crew health created by exploring a beyond low earth orbit destination, traversing the terrain of asteroid surfaces, and the effects of variable gravity environments. Limited communications with ground-based personnel for diagnosis and consultation of medical events require increased crew autonomy when diagnosing conditions, creating treatment plans, and executing procedures. Scope: The Exploration Medical System Demonstration (EMSD) project will be a test bed on the International Space Station (ISS) to show an end-to-end medical system assisting the Crew Medical Officers (CMO) in optimizing medical care delivery and medical data management during a mission. NEA medical care challenges include resource and resupply constraints limiting the extent to which medical conditions can be treated, inability to evacuate to Earth during many mission phases, and rendering of medical care by a non-clinician. The system demonstrates the integration of medical technologies and medical informatics tools for managing evidence and decision making. Project Objectives: The objectives of the EMSD project are to: a) Reduce and possibly eliminate the time required for a crewmember and ground personnel to manage medical data from one application to another. b) Demonstrate crewmember's ability to access medical data/information via a software solution to assist/aid in the treatment of a medical condition. c) Develop a common data management architecture that can be ubiquitously used to automate repetitive data collection, management, and communications tasks for all crew health and life sciences activities. d) Develop a common data management architecture that allows for scalability, extensibility, and interoperability of data sources and data users. e) Lower total cost of ownership for development and sustainment of peripheral hardware and software that use EMSD for data management f) Provide
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Energy Technology Data Exchange (ETDEWEB)
NONE
1993-12-31
The third planning workshop of the Human Genome Diversity Project was held on the campus of the US National Institutes of Health in Bethesda, Maryland, from February 16 through February 18, 1993. The second day of the workshop was devoted to an exploration of the ethical and human-rights implications of the Project. This open meeting centered on three roundtables, involving 12 invited participants, and the resulting discussions among all those present. Attendees and their affiliations are listed in the attached Appendix A. The discussion was guided by a schedule and list of possible issues, distributed to all present and attached as Appendix B. This is a relatively complete, and thus lengthy, summary of the comments at the meeting. The beginning of the summary sets out as conclusions some issues on which there appeared to be widespread agreement, but those conclusions are not intended to serve as a set of detailed recommendations. The meeting organizer is distributing his recommendations in a separate memorandum; recommendations from others who attended the meeting are welcome and will be distributed by the meeting organizer to the participants and to the Project committee.
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McCurdy, Howard E.
1992-01-01
This folder contains working papers collected to date on a NASA-sponsored history project to document the events leading up to the July 20, 1989 speech setting forth the objectives of the Space Exploration Initiative. Included are a chronology of events, briefing papers produced by the NASA Working Group laying out proposal, briefing charts used to present the proposal, a copy of the President's speech, and an essay summarizing the events that led up to the announcement. Additionally, two fo the interviews conducted as part of the project are enclosed.
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Exploring quantum physics through hands-on projects
Prutchi, David
2012-01-01
Build an intuitive understanding of the principles behind quantum mechanics through practical construction and replication of original experiments With easy-to-acquire, low-cost materials and basic knowledge of algebra and trigonometry, Exploring Quantum Physics through Hands-on Projects takes readers step by step through the process of re-creating scientific experiments that played an essential role in the creation and development of quantum mechanics. From simple measurements of Planck's constant to testing violations of Bell's inequalities using entangled photons, Exploring Quantum Physics through Hands-on Projects not only immerses readers in the process of quantum mechanics, it provides insight into the history of the field--how the theories and discoveries apply to our world not only today, but also tomorrow. By immersing readers in groundbreaking experiments that can be performed at home, school, or in the lab, this first-ever, hands-on book successfully demystifies the world of quantum physics for...
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Humanity in God's Image: An Interdisciplinary Exploration
DEFF Research Database (Denmark)
Welz, Claudia
. Claudia Welz offers an interdisciplinary exploration of theological and ethical 'visions' of the invisible. By analysing poetry and art, Welz exemplifies human self-understanding in the interface between the visual and the linguistic. The content of the imago Dei cannot be defined apart from the image......How can we, in our times, understand the biblical concept that human beings have been created in the image of an invisible God? This is a perennial but increasingly pressing question that lies at the heart of theological anthropology. Humanity in God's Image: An Interdisciplinary Exploration...
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Kuna, Jason
2001-01-01
This article explores the impact of the mapping work of the Human Genome Project on individuals with mental retardation and the negative effects of genetic testing. The potential to identify disabilities and the concept of eugenics are discussed, along with ethical issues surrounding potential genetic therapies. (Contains references.) (CR)
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NASA Human Health and Performance Center: Open innovation successes and collaborative projects
Richard, Elizabeth E.; Davis, Jeffrey R.
2014-11-01
In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, setting the course for development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the successful execution of the strategy, driving organizational change through open innovation efforts and collaborative projects, including efforts of the NASA Human Health and Performance Center (NHHPC).
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Proposed Project Selection Method for Human Support Research and Technology Development (HSR&TD)
Jones, Harry
2005-01-01
The purpose of HSR&TD is to deliver human support technologies to the Exploration Systems Mission Directorate (ESMD) that will be selected for future missions. This requires identifying promising candidate technologies and advancing them in technology readiness until they are acceptable. HSR&TD must select an may of technology development projects, guide them, and either terminate or continue them, so as to maximize the resulting number of usable advanced human support technologies. This paper proposes an effective project scoring methodology to support managing the HSR&TD project portfolio. Researchers strongly disagree as to what are the best technology project selection methods, or even if there are any proven ones. Technology development is risky and outstanding achievements are rare and unpredictable. There is no simple formula for success. Organizations that are satisfied with their project selection approach typically use a mix of financial, strategic, and scoring methods in an open, established, explicit, formal process. This approach helps to build consensus and develop management insight. It encourages better project proposals by clarifying the desired project attributes. We propose a project scoring technique based on a method previously used in a federal laboratory and supported by recent research. Projects are ranked by their perceived relevance, risk, and return - a new 3 R's. Relevance is the degree to which the project objective supports the HSR&TD goal of developing usable advanced human support technologies. Risk is the estimated probability that the project will achieve its specific objective. Return is the reduction in mission life cycle cost obtained if the project is successful. If the project objective technology performs a new function with no current cost, its return is the estimated cash value of performing the new function. The proposed project selection scoring method includes definitions of the criteria, a project evaluation
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The design explorer project: Using a cognitive framework to support knowledge exploration
DEFF Research Database (Denmark)
Pejtersen, A. M.; Sonnenwald, D.H.; Buur, J.
1997-01-01
the 'Design Explorer' research project whose goal is to specify requirements for an information system that will effectively help design team members from different domains and organizational cultures to locate and utilize diverse information sources and interact more effectively throughout the design process....... The project introduces a new approach to support of design; instead of design guidelines, support is given by creating a transparent information environment in which designers can navigate freely according to their individual preferences. The project is based on a framework that structures the dimensions......, and various related task spaces, domain activities, decisionmaking activities, division and coordination of work, and social organization. The framework is the result of a generalization of experiences from field studies in and design of support systems for a variety of modern work domains, such as process...
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Strategies For Human Exploration Leading To Human Colonization of Space
Smitherman, David; Everett, Harmon
2009-01-01
Enabling the commercial development of space is key to the future colonization of space and key to a viable space exploration program. Without commercial development following in the footsteps of exploration it is difficult to justify and maintain public interest in the efforts. NASA's exploration program has suffered from the lack of a good commercial economic strategy for decades. Only small advances in commercial space have moved forward, and only up to Earth orbit with the commercial satellite industry. A way to move beyond this phase is to begin the establishment of human commercial activities in space in partnership with the human exploration program. In 2007 and 2008, the authors researched scenarios to make space exploration and commercial space development more feasible as part of their graduate work in the Space Architecture Program at the Sasakawa International Center for Space Architecture at the University of Houston, Houston, Texas. Through this research it became apparent that the problems facing future colonization are much larger than the technology being developed or the international missions that our space agencies are pursuing. These issues are addressed in this paper with recommendations for space exploration, commercial development, and space policy that are needed to form a strategic plan for human expansion into space. In conclusion, the authors found that the current direction in space as carried out by our space agencies around the world is definitely needed, but is inadequate and incapable of resolving all of the issues that inhibit commercial space development. A bolder vision with strategic planning designed to grow infrastructures and set up a legal framework for commercial markets will go a long way toward enabling the future colonization of space.
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Kidd, Luanne; Morris, Kenneth B.; Self, Timothy A.
2007-01-01
The U.S. Vision for Space Exploration directs NASA to retire the Space Shuttle in 2010 and replace it with safe, reliable, and cost-effective space transportation systems for crew and cargo travel to the Moon, Mars, and beyond. Such emerging space transportation initiatives face massive organizational challenges, including building and nurturing an experienced, dedicated team with the right skills for the required tasks; allocating and tracking the fiscal capital invested in achieving technical progress against an integrated master schedule; and turning generated data into useful knowledge that equips the team to design and develop superior products for customers and stakeholders. It has been more than 30 years since the Space Shuttle was designed; therefore, the current aerospace workforce has limited experience with developing new designs for human-rated spaceflight hardware. To accomplish these activities, NASA is using a wide range of state-of-the-art information technology tools that connect its diverse, decentralized teams and provide timely, accurate information for decision makers. In addition, business professionals are assisting technical managers with planning, tracking, and forecasting resource use against an integrated master schedule that horizontally and vertically interlinks hardware elements and milestone events. Furthermore, NASA is employing a wide variety of strategies to ensure that it has the motivated and qualified staff it needs for the tasks ahead. This paper discusses how NASA's Exploration Launch Projects Office, which is responsible for delivering these new launch vehicles, integrates its resources to create an engineering business environment that promotes mission success, which is defined by replacing the Space Shuttle by 2014 and returning to the Moon by 2020.
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NASA Human Health and Performance Center: Open Innovation Successes and Collaborative Projects
Davis, Jeffrey R.; Richard, Elizabeth E.
2014-01-01
In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, which resulted in the development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the open innovation successes and collaborative projects developed over this timeframe, including the efforts of the NASA Human Health and Performance Center (NHHPC), which was established to advance human health and performance innovations for spaceflight and societal benefit via collaboration in new markets.
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Exploration of projective techniques to unravel health perception
Sijtsema, S.J.; Linnemann, A.R.; Backus, G.B.C.; Jongen, W.M.F.; Gaasbeek, van A.F.; Dagevos, H.
2007-01-01
Purpose - This paper seeks to explore the design, organisation and application of group discussions in which projective techniques (expressive and associative) are used to unravel health perception of consumers in cognitive and affective terms. Design/methodology/approach - A trained moderator led
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Flowers behind the back of the universe: A cosmic art project exploring the invisible
Tanaka, Yuri; Doser, Michael; Sakurai, Ryu; Shimoyama, Hajime; Takahashi, Ryo
2018-05-01
What can be seen within this universe? Since humans are not instinctively aware of the limitations of their sensorium, what is being missed is not immediately obvious. Aiming to explore with our imagination the invisible elements in the universe, we created an interactive cosmic art project in collaboration with the Gunma Astronomical Observatory, and the Polytech Festival in Moscow. In this paper, we firstly address the topic of dark matter, from the physics point of view, the concept in our project touching upon the invisible beauty in the universe, and then discuss the practical methodology for the process of making the installation. This installation was laid out based on a map of constellations from where people were able to see the antipode of Moscow, an opposite point from the venue where the installation was set, in analogy to illustrating what exists, but can not be seen. Using origami flowers - made in the course of a workshop by the visitors of the festival - as a metaphor of the beauty and transience of life, the installation seeks to deepen the awareness of participants about the numerous invisible structures in the universe. Placing them within reflective structures underlines both our reliance on technology to make the invisible visible, and the influence of the point of view on how we perceive and interpret the resulting representations. In their various forms and colors, these flowers can be seen as metaphorical mirror images of that which lies at the antipodes of our awareness: of colorful gas glowing in radio waves, supernovas in their many x-ray hues, dark matter, neutrinos, gravitational waves, dark energy. Considering both the invisible scenery of the sky and the invisible elements of beauty in the universe as lying behind the 'back' of the universe, hidden to our senses, this project explores a new way of communication between humans and the ubiquitous invisible in an artistic manner. Finally, the whole process of this project is summarized
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[The human variome project and its progress].
Gao, Shan; Zhang, Ning; Zhang, Lei; Duan, Guang-You; Zhang, Tao
2010-11-01
The main goal of post genomics is to explain how the genome, the map of which has been constructed in the Human Genome Project, affacts activities of life. This leads to generate multiple "omics": structural genomics, functional genomics, proteomics, metabonomics, et al. In Jun. 2006, Melbourne, Australia, Human Genome Variation Society (HGVS) initiated the Human Variome Project (HVP) to collect all the sequence variation and polymorphism data worldwidely. HVP is to search and determine those mutations related with human diseases by association study between genetype and phenotype on the scale of genome level and other methods. Those results will be translated into clinical application. Considering the potential effects of this project on human health, this paper introduced its origin and main content in detail and discussed its meaning and prospect.
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Automation and Robotics for Human Mars Exploration (AROMA)
Hofmann, Peter; von Richter, Andreas
2003-01-01
Automation and Robotics (A&R) systems are a key technology for Mars exploration. All over the world initiatives in this field aim at developing new A&R systems and technologies for planetary surface exploration. From December 2000 to February 2002 Kayser-Threde GmbH, Munich, Germany lead a study called AROMA (Automation and Robotics for Human Mars Exploration) under ESA contract in order to define a reference architecture of A&R elements in support of a human Mars exploration program. One of the goals of this effort is to initiate new developments and to maintain the competitiveness of European industry within this field. c2003 Published by Elsevier Science Ltd.
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Genomics and the human genome project: implications for psychiatry
Kelsoe, J R
2004-01-01
In the past decade the Human Genome Project has made extraordinary strides in understanding of fundamental human genetics. The complete human genetic sequence has been determined, and the chromosomal location of almost all human genes identified. Presently, a large international consortium, the HapMap Project, is working to identify a large portion of genetic variation in different human populations and the structure and relationship of these variants to each other. The Human Genome Project h...
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Implications of the Human Genome Project
Energy Technology Data Exchange (ETDEWEB)
Kitcher, P.
1998-11-01
The Human Genome Project (HGP), launched in 1991, aims to map and sequence the human genome by 2006. During the fifteen-year life of the project, it is projected that $3 billion in federal funds will be allocated to it. The ultimate aims of spending this money are to analyze the structure of human DNA, to identify all human genes, to recognize the functions of those genes, and to prepare for the biology and medicine of the twenty-first century. The following summary examines some of the implications of the program, concentrating on its scientific import and on the ethical and social problems that it raises. Its aim is to expose principles that might be used in applying the information which the HGP will generate. There is no attempt here to translate the principles into detailed proposals for legislation. Arguments and discussion can be found in the full report, but, like this summary, that report does not contain any legislative proposals.
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[Projective identification in human relations].
Göka, Erol; Yüksel, Fatih Volkan; Göral, F Sevinç
2006-01-01
Melanie Klein, one of the pioneers of Object Relations Theory, first defined "projective identification", which is regarded as one of the most efficacious psychoanalytic concepts after the discovery of the "unconscious". Examination of the literature on "projective identification" shows that there are various perspectives and theories suggesting different uses of this concept. Some clinicians argue that projective identification is a primitive defense mechanism observed in severe psychopathologies like psychotic disorder and borderline personality disorder, where the intra-psychic structure has been damaged severely. Others suggest it to be an indispensable part of the transference and counter-transference between the therapist and the patient during psychotherapy and it can be used as a treatment material in the therapy by a skillful therapist. The latter group expands the use of the concept through normal daily relationships by stating that projective identification is one type of communication and part of the main human relation mechanism operating in all close relationships. Therefore, they suggest that projective identification has benign forms experienced in human relations as well as malign forms seen in psychopathologies. Thus, discussions about the definition of the concept appear complex. In order to clarify and overcome the complexity of the concept, Melanie Klein's and other most important subsequent approaches are discussed in this review article. Thereby, the article aims to explain its important function in understanding the psychopathologies, psychotherapeutic relationships and different areas of normal human relations.
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Human exploration mission studies
Cataldo, Robert L.
1989-01-01
The Office of Exploration has established a process whereby all NASA field centers and other NASA Headquarters offices participate in the formulation and analysis of a wide range of mission strategies. These strategies were manifested into specific scenarios or candidate case studies. The case studies provided a systematic approach into analyzing each mission element. First, each case study must address several major themes and rationale including: national pride and international prestige, advancement of scientific knowledge, a catalyst for technology, economic benefits, space enterprise, international cooperation, and education and excellence. Second, the set of candidate case studies are formulated to encompass the technology requirement limits in the life sciences, launch capabilities, space transfer, automation, and robotics in space operations, power, and propulsion. The first set of reference case studies identify three major strategies: human expeditions, science outposts, and evolutionary expansion. During the past year, four case studies were examined to explore these strategies. The expeditionary missions include the Human Expedition to Phobos and Human Expedition to Mars case studies. The Lunar Observatory and Lunar Outpost to Early Mars Evolution case studies examined the later two strategies. This set of case studies established the framework to perform detailed mission analysis and system engineering to define a host of concepts and requirements for various space systems and advanced technologies. The details of each mission are described and, specifically, the results affecting the advanced technologies required to accomplish each mission scenario are presented.
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Origins of the Human Genome Project.
Watson, J D; Cook-Deegan, R M
1991-01-01
The Human Genome Project has become a reality. Building on a debate that dates back to 1985, several genome projects are now in full stride around the world, and more are likely to form in the next several years. Italy began its genome program in 1987, and the United Kingdom and U.S.S.R. in 1988. The European communities mounted several genome projects on yeast, bacteria, Drosophila, and Arabidospis thaliana (a rapidly growing plant with a small genome) in 1988, and in 1990 commenced a new 2-year program on the human genome. In the United States, we have completed the first year of operation of the National Center for Human Genome Research at the National Institutes of Health (NIH), now the largest single funding source for genome research in the world. There have been dedicated budgets focused on genome-scale research at NIH, the U.S. Department of Energy, and the Howard Hughes Medical Institute for several years, and results are beginning to accumulate. There were three annual meetings on genome mapping and sequencing at Cold Spring Harbor, New York, in the spring of 1988, 1989, and 1990; the talks have shifted from a discussion about how to approach problems to presenting results from experiments already performed. We have finally begun to work rather than merely talk. The purpose of genome projects is to assemble data on the structure of DNA in human chromosomes and those of other organisms. A second goal is to develop new technologies to perform mapping and sequencing. There have been impressive technical advances in the past 5 years since the debate about the human genome project began. We are on the verge of beginning pilot projects to test several approaches to sequencing long stretches of DNA, using both automation and manual methods. Ordered sets of yeast artificial chromosome and cosmid clones have been assembled to span more than 2 million base pairs of several human chromosomes, and a region of 10 million base pairs has been assembled for
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The Advanced Exploration Systems Water Recovery Project: Innovation on 2 Fronts
Sarguisingh, Miriam M.; Neumeyer, Derek; Shull, Sarah
2012-01-01
As NASA looks forward to sending humans farther away from Earth, we will have to develop a transportation architecture that is highly reliable and that can sustain life for long durations without the benefit of Earth s proximity for continuous resupply or even operational guidance. NASA has consistently been challenged with performing great feats of innovation, but particularly in this time of economic stress, we are challenged to go farther with less. The Advanced Exploration Systems (AES) projects were implemented to address both of these needs by not only developing innovative technologies, but by incorporating innovative management styles and processes that foster the needed technical innovation given a small amount of resources. This presentation explains how the AES Water Recovery Project is exhibiting innovation on both fronts; technical and process. The AES Water Recovery Project (WRP) is actively engineering innovative technologies in order to maximize the efficiency of water recovery. The development of reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support (ECLS) is critical to enable long-duration human missions outside of low-Earth orbit. Recycling of life support consumables is necessary to reduce resupply mass and provide for vehicle autonomy. To address this, the WRP is working on a rotary distiller that has shown enhanced performance over the state-of-the-art (SOA). Additionally, the WRP is looking at innovative ways to address issues present in the state-of-the-art (SOA) systems pertaining to toxicity and calcium scale buildup. As an AES project, the WRP has a more streamlined Skunk Works like approach to technology development intended to reduce overhead but achieve a more refined end product. The project has incorporated key partnerships between NASA centers as well as between NASA and industry. A minimal project management style has been implemented such that risks are managed and
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Nguyen, Hung D.; Steele, Gynelle C.
2016-01-01
This report is intended to help NASA program and project managers incorporate Glenn Research Center Small Business Innovation Research/Small Business Technology Transfer (SBIR)/(STTR) technologies into NASA Human Exploration and Operations Mission Directorate (HEOMD) programs and projects. Other Government and commercial project managers can also find this useful. Introduction Incorporating Small Business Innovation Research (SBIR)-developed technology into NASA projects is important, especially given the Agency's limited resources for technology development. The SBIR program's original intention was for technologies that had completed Phase II to be ready for integration into NASA programs, however, in many cases there is a gap between Technology Readiness Levels (TRLs) 5 and 6 that needs to be closed. After SBIR Phase II projects are completed, the technology is evaluated against various parameters and a TRL rating is assigned. Most programs tend to adopt more mature technologies-at least TRL 6 to reduce the risk to the mission rather than adopt TRLs between 3 and 5 because those technologies are perceived as too risky. The gap between TRLs 5 and 6 is often called the "Valley of Death" (Figure 1), and historically it has been difficult to close because of a lack of funding support from programs. Several papers have already suggested remedies on how to close the gap (Refs. 1 to 4).
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Human collective intelligence under dual exploration-exploitation dilemmas.
Directory of Open Access Journals (Sweden)
Wataru Toyokawa
Full Text Available The exploration-exploitation dilemma is a recurrent adaptive problem for humans as well as non-human animals. Given a fixed time/energy budget, every individual faces a fundamental trade-off between exploring for better resources and exploiting known resources to optimize overall performance under uncertainty. Colonies of eusocial insects are known to solve this dilemma successfully via evolved coordination mechanisms that function at the collective level. For humans and other non-eusocial species, however, this dilemma operates within individuals as well as between individuals, because group members may be motivated to take excessive advantage of others' exploratory findings through social learning. Thus, even though social learning can reduce collective exploration costs, the emergence of disproportionate "information scroungers" may severely undermine its potential benefits. We investigated experimentally whether social learning opportunities might improve the performance of human participants working on a "multi-armed bandit" problem in groups, where they could learn about each other's past choice behaviors. Results showed that, even though information scroungers emerged frequently in groups, social learning opportunities reduced total group exploration time while increasing harvesting from better options, and consequentially improved collective performance. Surprisingly, enriching social information by allowing participants to observe others' evaluations of chosen options (e.g., Amazon's 5-star rating system in addition to choice-frequency information had a detrimental impact on performance compared to the simpler situation with only the choice-frequency information. These results indicate that humans groups can handle the fundamental "dual exploration-exploitation dilemmas" successfully, and that social learning about simple choice-frequencies can help produce collective intelligence.
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NASA Technology Area 07: Human Exploration Destination Systems Roadmap
Kennedy, Kriss J.; Alexander, Leslie; Landis, Rob; Linne, Diane; Mclemore, Carole; Santiago-Maldonado, Edgardo; Brown, David L.
2011-01-01
This paper gives an overview of the National Aeronautics and Space Administration (NASA) Office of Chief Technologist (OCT) led Space Technology Roadmap definition efforts. This paper will given an executive summary of the technology area 07 (TA07) Human Exploration Destination Systems (HEDS). These are draft roadmaps being reviewed and updated by the National Research Council. Deep-space human exploration missions will require many game changing technologies to enable safe missions, become more independent, and enable intelligent autonomous operations and take advantage of the local resources to become self-sufficient thereby meeting the goal of sustained human presence in space. Taking advantage of in-situ resources enhances and enables revolutionary robotic and human missions beyond the traditional mission architectures and launch vehicle capabilities. Mobility systems will include in-space flying, surface roving, and Extra-vehicular Activity/Extravehicular Robotics (EVA/EVR) mobility. These push missions will take advantage of sustainability and supportability technologies that will allow mission independence to conduct human mission operations either on or near the Earth, in deep space, in the vicinity of Mars, or on the Martian surface while opening up commercialization opportunities in low Earth orbit (LEO) for research, industrial development, academia, and entertainment space industries. The Human Exploration Destination Systems (HEDS) Technology Area (TA) 7 Team has been chartered by the Office of the Chief Technologist (OCT) to strategically roadmap technology investments that will enable sustained human exploration and support NASA s missions and goals for at least the next 25 years. HEDS technologies will enable a sustained human presence for exploring destinations such as remote sites on Earth and beyond including, but not limited to, LaGrange points, low Earth orbit (LEO), high Earth orbit (HEO), geosynchronous orbit (GEO), the Moon, near
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United States Human Access to Space, Exploration of the Moon and Preparation for Mars Exploration
Rhatigan, Jennifer L.
2009-01-01
In the past, men like Leonardo da Vinci and Jules Verne imagined the future and envisioned fantastic inventions such as winged flying machines, submarines, and parachutes, and posited human adventures like transoceanic flight and journeys to the Moon. Today, many of their ideas are reality and form the basis for our modern world. While individual visionaries like da Vinci and Verne are remembered for the accuracy of their predictions, today entire nations are involved in the process of envisioning and defining the future development of mankind, both on and beyond the Earth itself. Recently, Russian, European, and Chinese teams have all announced plans for developing their own next generation human space vehicles. The Chinese have announced their intention to conduct human lunar exploration, and have flown three crewed space missions since 2003, including a flight with three crew members to test their extravehicular (spacewalking) capabilities in September 2008. Very soon, the prestige, economic development, scientific discovery, and strategic security advantage historically associated with leadership in space exploration and exploitation may no longer be the undisputed province of the United States. Much like the sponsors of the seafaring explorers of da Vinci's age, we are motivated by the opportunity to obtain new knowledge and new resources for the growth and development of our own civilization. NASA's new Constellation Program, established in 2005, is tasked with maintaining the United States leadership in space, exploring the Moon, creating a sustained human lunar presence, and eventually extending human operations to Mars and beyond. Through 2008, the Constellation Program developed a full set of detailed program requirements and is now completing the preliminary design phase for the new Orion Crew Exploration Vehicle (CEV), the Ares I Crew Launch Vehicle, and the associated infrastructure necessary for humans to explore the Moon. Component testing is well
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The Value of Humans in the Biological Exploration of Space
Cockell, C. S.
2004-06-01
Regardless of the discovery of life on Mars, or of "no apparent life" on Mars, the questions that follow will provide a rich future for biological exploration. Extraordinary pattern recognition skills, decadal assimilation of data and experience, and rapid sample acquisition are just three of the characteristics that make humans the best means we have to explore the biological potential of Mars and other planetary surfaces. I make the case that instead of seeing robots as in conflict, or even in support, of human exploration activity, from the point of view of scientific data gathering and analysis, we should view humans as the most powerful robots we have, thus removing the separation that dogs discussions on the exploration of space. The narrow environmental requirements of humans, although imposing constraints on the life support systems required, is more than compensated for by their capabilities in biological exploration. I support this view with an example of the "Christmas present effect," a simple demonstration of human data and pattern recognition capabilities.
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Asteroid exploration and utilization: The Hawking explorer
Carlson, Alan; Date, Medha; Duarte, Manny; Erian, Neil; Gafka, George; Kappler, Peter; Patano, Scott; Perez, Martin; Ponce, Edgar; Radovich, Brian
1991-01-01
The Earth is nearing depletion of its natural resources at a time when human beings are rapidly expanding the frontiers of space. The resources which may exist on asteroids could have enormous potential for aiding and enhancing human space exploration as well as life on Earth. With the possibly limitless opportunities that exist, it is clear that asteroids are the next step for human existence in space. This report comprises the efforts of NEW WORLDS, Inc. to develop a comprehensive design for an asteroid exploration/sample return mission. This mission is a precursor to proof-of-concept missions that will investigate the validity of mining and materials processing on an asteroid. Project STONER (Systematic Transfer of Near Earth Resources) is based on two utilization scenarios: (1) moving an asteroid to an advantageous location for use by Earth; and (2) mining an asteroids and transporting raw materials back to Earth. The asteroid explorer/sample return mission is designed in the context of both scenarios and is the first phase of a long range plane for humans to utilize asteroid resources. The report concentrates specifically on the selection of the most promising asteroids for exploration and the development of an exploration scenario. Future utilization as well as subsystem requirements of an asteroid sample return probe are also addressed.
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Exploring protein structure and dynamics through a project-oriented biochemistry laboratory module.
Lipchock, James M; Ginther, Patrick S; Douglas, Bonnie B; Bird, Kelly E; Patrick Loria, J
2017-09-01
Here, we present a 10-week project-oriented laboratory module designed to provide a course-based undergraduate research experience in biochemistry that emphasizes the importance of biomolecular structure and dynamics in enzyme function. This module explores the impact of mutagenesis on an important active site loop for a biomedically-relevant human enzyme, protein tyrosine phosphatase 1B (PTP1B). Over the course of the semester students guide their own mutant of PTP1B from conception to characterization in a cost-effective manner and gain exposure to fundamental techniques in biochemistry, including site-directed DNA mutagenesis, bacterial recombinant protein expression, affinity column purification, protein quantitation, SDS-PAGE, and enzyme kinetics. This project-based approach allows an instructor to simulate a research setting and prepare students for productive research beyond the classroom. Potential modifications to expand or contract this module are also provided. © 2017 by The International Union of Biochemistry and Molecular Biology, 45(5):403-410, 2017. © 2017 The International Union of Biochemistry and Molecular Biology.
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Rusman, Ellen; Rajagopal, Kamakshi; Stoyanov, Slavi; Van Maele, Jan
2011-01-01
Rusman, E., Rajagopal, K., Stoyanov, S., & Van Maele, J. (2011, 20-21 October). Exploration of Exploitation Approaches of European Projects on ICT and Foreign Language Learning: the CEFcult project case. Paper presented at the 4th International Conference ICT for Language Learning, Florence, Italy.
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PROJECT MANAGEMENT FOR THE STATE-GOVERNED GEOLOGICAL EXPLORATION OF MINERAL RESOURCES
Directory of Open Access Journals (Sweden)
A. M. Lygin
2018-03-01
Full Text Available The relevance of the research. Creating high-efficient and innovation-oriented system of studying the subsoil and the mineral resource base is one of the priority areas of developing the geological sphere. The purpose of the present study is to substantiate the rationale for the adoption of the project management methods for the exploration work. Research methods: method of system analysis, method of comparison and analogies, and method of scientific generalization. The results and their application. This article deals with the content of the main standard legislative documents which determine the strategy and lines of the country’s geological sector development in the nearest future. The article discloses the purposes and their strategic objectives and the content of the state program of the Russian Federation called “Reproduction and use of natural resources”. The resource support of the program and its subroutines is also revealed. The structure of geological industry management in modern conditions is presented. The main activities for restructuring of the geological industry are set out. They include the following points. The transformation of the Federal state unitary enterprises of information and expert profile, the advancement of scientific organizations engaged in scientific and analytical support of performed public functions. These functions are concerned with the geological study of subsoil and reproduction of the mineral resource base, as well as improving its management. The consolidation of specialized geological organizations on the types of exploration and mining, and also the main results of reorganization of the enterprises is taken into account. All of the aforementioned is subordinated to and is conducted by the Federal Agency for subsoil management. The shortcomings of the current system of management of works on the state geological study of the subsoil were revealed at the expense of the Federal budget. The
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Exploring overlay journals: the RIOJA project
CERN. Geneva
2007-01-01
Researchers in cosmology and astrophysics depend on the arXiv repository for the registration and dissemination of their work, as well as for current awareness, yet they continue to submit papers to journals for review. Could rapid quality certification be overlaid directly onto the arXiv repository? This presentation introduces the RIOJA (Repository Interface to Overlaid Journal Archives) project, on which a group of cosmology researchers from the UK is working with UCL Library Services and Cornell University. The project is creating a tool to support the overlay of journals onto repositories, and will demonstrate a cosmology journal overlaid on top of arXiv. RIOJA will also work with the cosmology community to explore the social and economic aspects of journal overlay in this discipline: what other value, besides the quality stamp, does journal publication typically add? What are the costs of the ideal overlay journal for this community, and how could those costs be recovered? Would researchers real...
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Schmidt, George R.; Landis, Geoffrey A.; Oleson, Steven R.
2012-11-01
This paper presents an exploration strategy for human missions beyond Low Earth Orbit (LEO) and the Moon that combines the best features of human and robotic spaceflight. This "Human Exploration using Real-time Robotic Operations" (HERRO) strategy refrains from placing humans on the surfaces of the Moon and Mars in the near-term. Rather, it focuses on sending piloted spacecraft and crews into orbit around Mars and other exploration targets of interest, and conducting astronaut exploration of the surfaces using telerobots and remotely-controlled systems. By eliminating the significant communications delay or "latency" with Earth due to the speed of light limit, teleoperation provides scientists real-time control of rovers and other sophisticated instruments. This in effect gives them a "virtual presence" on planetary surfaces, and thus expands the scientific return at these destinations. HERRO mitigates several of the major issues that have hindered the progress of human spaceflight beyond Low Earth Orbit (LEO) by: (1) broadening the range of destinations for near-term human missions; (2) reducing cost and risk through less complexity and fewer man-rated elements; (3) offering benefits of human-equivalent in-situ cognition, decision-making and field-work on planetary bodies; (4) providing a simpler approach to returning samples from Mars and planetary surfaces; and (5) facilitating opportunities for international collaboration through contribution of diverse robotic systems. HERRO provides a firm justification for human spaceflight—one that expands the near-term capabilities of scientific exploration while providing the space transportation infrastructure needed for eventual human landings in the future.
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Energy Technology Data Exchange (ETDEWEB)
Fairbank, Brian D. [Nevada Geothermal Power Company, Vancouver (Canada); Smith, Nicole [Nevada Geothermal Power Company, Vancouver (Canada)
2015-06-10
The Crump Geyser Exploration and Drilling Project – High Precision Geophysics and Detailed Structural Exploration and Slim Well Drilling ran from January 29, 2010 to September 30, 2013. During Phase 1 of the project, collection of all geophysical surveys was completed as outlined in the Statement of Project Objectives. In addition, a 5000-foot full sized exploration well was drilled by Ormat, and preexisting drilling data was discovered for multiple temperature gradient wells within the project area. Three dimensional modeling and interpretation of results from the geophysical surveys and drilling data gave confidence to move to the project into Phase 2 drilling. Geological and geophysical survey interpretations combined with existing downhole temperature data provided an ideal target for the first slim-hole drilled as the first task in Phase 2. Slim-hole 35-34 was drilled in September 2011 and tested temperature, lithology, and permeability along the primary range-bounding fault zone near its intersection with buried northwest-trending faults that have been identified using geophysical methods. Following analysis of the results of the first slim-hole 35-34, the second slim hole was not drilled and subsequent project tasks, including flowing differential self-potential (FDSP) surveys that were designed to detail the affect of production and injection on water flow in the shallow aquifer, were not completed. NGP sold the Crump project to Ormat in August 2014, afterwards, there was insufficient time and interest from Ormat available to complete the project objectives. NGP was unable to continue managing the award for a project they did not own due to liability issues and Novation of the award was not a viable option due to federal award timelines. NGP submitted a request to mutually terminate the award on February 18, 2015. The results of all of the technical surveys and drilling are included in this report. Fault interpretations from surface geology, aeromag
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Human Power Empirically Explored
Energy Technology Data Exchange (ETDEWEB)
Jansen, A.J.
2011-01-18
Harvesting energy from the users' muscular power to convert this into electricity is a relatively unknown way to power consumer products. It nevertheless offers surprising opportunities for product designers; human-powered products function independently from regular power infrastructure, are convenient and can be environmentally and economically beneficial. This work provides insight into the knowledge required to design human-powered energy systems in consumer products from a scientific perspective. It shows the developments of human-powered products from the first introduction of the BayGen Freeplay radio in 1995 till current products and provides an overview and analysis of 211 human-powered products currently on the market. Although human power is generally perceived as beneficial for the environment, this thesis shows that achieving environmental benefit is only feasible when the environmental impact of additional materials in the energy conversion system is well balanced with the energy demands of the products functionality. User testing with existing products showed a preference for speeds in the range of 70 to 190 rpm for crank lengths from 32 to 95 mm. The muscular input power varied from 5 to 21 W. The analysis of twenty graduation projects from the Faculty of Industrial Design Engineering in the field of human-powered products, offers an interesting set of additional practice based design recommendations. The knowledge based approach of human power is very powerful to support the design of human-powered products. There is substantial potential for improvements in the domains energy conversion, ergonomics and environment. This makes that human power, when applied properly, is environmentally and economically competitive over a wider range of applications than thought previously.
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Planetary Protection Issues in the Human Exploration of Mars
Criswell, Marvin E.; Race, M. S.; Rummel, J. D.; Baker, A.
2005-01-01
This workshop report, long delayed, is the first 21st century contribution to what will likely be a series of reports examining the effects of human exploration on the overall scientific study of Mars. The considerations of human-associated microbial contamination were last studied in a 1990 workshop ("Planetary Protection Issues and Future Mars Missions," NASA CP-10086, 1991), but the timing of that workshop allowed neither a careful examination of the full range of issues, nor an appreciation for the Mars that has been revealed by the Mars Global Surveyor and Mars Pathfinder missions. Future workshops will also have the advantage of Mars Odyssey, the Mars Exploration Rover missions, and ESA's Mars Express, but the Pingree Park workshop reported here had both the NCR's (1992) concern that "Missions carrying humans to Mars will contaminate the planet" and over a decade of careful study of human exploration objectives to guide them and to reconcile. A daunting challenge, and one that is not going to be simple (as the working title of this meeting, "When Ecologies Collide?" might suggest), it is clear that the planetary protection issues will have to be addressed to enable human explorers to safely and competently extend out knowledge about Mars, and its potential as a home for life whether martian or human.
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Kidd, Luanne; Morris, Kenneth B.; Self, Tim
2006-01-01
The U.S. Vision for Space Exploration directs NASA to retire the Space Shuttle in 2010 and replace it with safe, reliable, and cost-effective space transportation systems for crew and cargo travel to the Moon, Mars, and beyond. Such emerging space transportation initiatives face massive organizational challenges, including building and nurturing an experienced, dedicated team with the right skills for the required tasks; allocating and tracking the fiscal capital invested in achieving technical progress against an integrated master schedule; and turning generated data into usehl knowledge that equips the team to design and develop superior products for customers and stakeholders. This paper discusses how NASA's Exploration Launch Projects Office, which is responsible for delivering these new launch vehicles, integrates these resources to create an engineering business environment that promotes mission success.
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The In-Situ Resource Utilization Project Under the New Exploration Enterprise
Larson, William E.; Sanders, Gerald B.
2010-01-01
The In Situ Resource Utilization Project under the Exploration Technology Development Program has been investing in technologies to produce Oxygen from the regolith of the moon for the last few years. Much of this work was demonstrated in a lunar analog field demonstration in February of 2010. This paper will provide an overview of the key technologies demonstrated at the field demonstration will be discussed a long with the changes expected in the ISRU project as a result of the new vision for Space Exploration proposed by the President and enacted by the Congress in the NASA Authorization Act of2010.
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Marmolejo, Jose; Ewert, Michael
2016-01-01
The Engineering Directorate at the NASA - Johnson Space Center is outfitting a 20-Foot diameter hypobaric chamber in Building 7 to support future deep-space Environmental Control & Life Support System (ECLSS) research as part of the Human Exploration System Test-bed for Integration and Advancement (HESTIA) Project. This human-rated chamber is the only NASA facility that has the unique experience, chamber geometry, infrastructure, and support systems capable of conducting this research. The chamber was used to support Gemini, Apollo, and SkyLab Missions. More recently, it was used to conduct 30-, 60-, and 90-day human ECLSS closed-loop testing in the 1990s to support the International Space Station and life support technology development. NASA studies show that both planetary surface and deep-space transit crew habitats will be 3-4 story cylindrical structures driven by human occupancy volumetric needs and launch vehicle constraints. The HESTIA facility offers a 3-story, 20-foot diameter habitat consistent with the studies' recommendations. HESTIA operations follow stringent processes by a certified test team that including human testing. Project management, analysis, design, acquisition, fabrication, assembly and certification of facility build-ups are available to support this research. HESTIA offers close proximity to key stakeholders including astronauts, Human Research Program (who direct space human research for the agency), Mission Operations, Safety & Mission Assurance, and Engineering Directorate. The HESTIA chamber can operate at reduced pressure and elevated oxygen environments including those proposed for deep-space exploration. Data acquisition, power, fluids and other facility resources are available to support a wide range of research. Recently completed HESTIA research consisted of unmanned testing of ECLSS technologies. Eventually, the HESTIA research will include humans for extended durations at reduced pressure and elevated oxygen to demonstrate
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Lupisella, Mark L.; Mueller, Thomas
2016-01-01
This paper will provide a summary and analysis of the SpaceOps 2015 Workshop all-day session on "Advanced Technologies for Robotic Exploration, Leading to Human Exploration", held at Fucino Space Center, Italy on June 12th, 2015. The session was primarily intended to explore how robotic missions and robotics technologies more generally can help lead to human exploration missions. The session included a wide range of presentations that were roughly grouped into (1) broader background, conceptual, and high-level operations concepts presentations such as the International Space Exploration Coordination Group Roadmap, followed by (2) more detailed narrower presentations such as rover autonomy and communications. The broader presentations helped to provide context and specific technical hooks, and helped lay a foundation for the narrower presentations on more specific challenges and technologies, as well as for the discussion that followed. The discussion that followed the presentations touched on key questions, themes, actions and potential international collaboration opportunities. Some of the themes that were touched on were (1) multi-agent systems, (2) decentralized command and control, (3) autonomy, (4) low-latency teleoperations, (5) science operations, (6) communications, (7) technology pull vs. technology push, and (8) the roles and challenges of operations in early human architecture and mission concept formulation. A number of potential action items resulted from the workshop session, including: (1) using CCSDS as a further collaboration mechanism for human mission operations, (2) making further contact with subject matter experts, (3) initiating informal collaborative efforts to allow for rapid and efficient implementation, and (4) exploring how SpaceOps can support collaboration and information exchange with human exploration efforts. This paper will summarize the session and provide an overview of the above subjects as they emerged from the SpaceOps 2015
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Attitudes towards the Human Genome Project.
Shahroudi, Julie; Shaw, Geraldine
Attitudes concerning the Human Genome Project were reported by faculty (N=40) and students (N=66) from a liberal arts college. Positive attitudes toward the project involved privacy, insurance and health, economic purposes, reproductive purposes, genetic counseling, religion and overall opinions. Negative attitudes were expressed regarding…
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The Human Genome Project: big science transforms biology and medicine.
Hood, Leroy; Rowen, Lee
2013-01-01
The Human Genome Project has transformed biology through its integrated big science approach to deciphering a reference human genome sequence along with the complete sequences of key model organisms. The project exemplifies the power, necessity and success of large, integrated, cross-disciplinary efforts - so-called 'big science' - directed towards complex major objectives. In this article, we discuss the ways in which this ambitious endeavor led to the development of novel technologies and analytical tools, and how it brought the expertise of engineers, computer scientists and mathematicians together with biologists. It established an open approach to data sharing and open-source software, thereby making the data resulting from the project accessible to all. The genome sequences of microbes, plants and animals have revolutionized many fields of science, including microbiology, virology, infectious disease and plant biology. Moreover, deeper knowledge of human sequence variation has begun to alter the practice of medicine. The Human Genome Project has inspired subsequent large-scale data acquisition initiatives such as the International HapMap Project, 1000 Genomes, and The Cancer Genome Atlas, as well as the recently announced Human Brain Project and the emerging Human Proteome Project.
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Directory of Open Access Journals (Sweden)
Suzaan Pretorius
2017-12-01
Full Text Available It is widely accepted that project leaders should adapt their behaviour to meet the unique leadership demands of a variety of situations. Recently, vertical, shared, and horizontal styles of leadership have gained prominence, especially in the project management literature. Several factors are believed to play a role in determining an appropriate balance between these leadership styles. This theoretical study explores the influence of project types, the stage in the project life cycle, organisational project management maturity, and the level of trust and collaboration between project team members on the appropriate balance of leadership styles in projects. This paper presents a conceptual framework of these factors, while empirical results will be reported on in the sequel to this paper.
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Human-centred automation: an explorative study
International Nuclear Information System (INIS)
Hollnagel, Erik; Miberg, Ann Britt
1999-05-01
The purpose of the programme activity on human-centred automation at the HRP is to develop knowledge (in the form of models and theories) and tools (in the form of techniques and simulators) to support design of automation that ensures effective human performance and comprehension. This report presents the work done on both the analytical and experimental side of this project. The analytical work has surveyed common definitions of automation and traditional design principles. A general finding is that human-centred automation usually is defined in terms of what it is not. This is partly due to a lack of adequate models and of human-automation interaction. Another result is a clarification of the consequences of automation, in particular with regard to situation awareness and workload. The experimental work has taken place as an explorative experiment in HAMMLAB in collaboration with IPSN (France). The purpose of this experiment was to increase the understanding of how automation influences operator performance in NPP control rooms. Two different types of automation (extensive and limited) were considered in scenarios having two different degrees of complexity (high and low), and involving diagnostic and procedural tasks. Six licensed NPP crews from the NPP at Loviisa, Finland, participated in the experiment. The dependent variables applied were plant performance, operator performance, self-rated crew performance, situation awareness, workload, and operator trust in the automation. The results from the diagnostic scenarios indicated that operators' judgement of crew efficiency was related to their level of trust in the automation, and further that operators trusted automation least and rated crew performance lowest in situations where crew performance was efficient and vice versa. The results from procedural scenarios indicated that extensive automation efficiently supported operators' performance, and further that operator' judgement of crew performance efficiency
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Marathon maternity oral history project: Exploring rural birthing through narrative methods.
Orkin, Aaron; Newbery, Sarah
2014-01-01
To explore how birthing and maternity care are understood and valued in a rural community. Oral history research. The rural community of Marathon, Ont, with a population of approximately 3500. A purposive selection of mothers, grandmothers, nurses, physicians, and community leaders in the Marathon medical catchment area. Interviews were conducted with a purposive sample, employing an oral history research methodology. Interviews were conducted non-anonymously in order to preserve the identity and personhood of participants. Interview transcripts were edited into short narratives. Oral histories offer perspectives and information not revealed in other quantitative or qualitative research methodologies. Narratives re-personalize and humanize medical research by offering researchers and practitioners the opportunity to bear witness to the personal stories affected through medical decision making. Eleven stand-alone narratives, published in this issue of Canadian Family Physician, form the project's findings. Similar to a literary text or short story, they are intended for personal reflection and interpretation by the reader. Presenting the results of these interviews as narratives requires the reader to participate in the research exercise and take part in listening to these women's voices. The project's narratives will be accessible to readers from academic and non-academic backgrounds and will interest readers in medicine and allied health professions, medical humanities, community development, gender studies, social anthropology and history, and literature. Sharing personal birthing experiences might inspire others to reevaluate and reconsider birthing practices and services in other communities. Where local maternity services are under threat, Marathon's stories might contribute to understanding the meaning and challenges of local birthing, and the implications of losing maternity services in rural Canada.
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Rusman, Ellen; Rajagopal, Kamakshi; Stoyanov, Slavi; Van Maele, Jan
2011-01-01
Rusman, E., Rajagopal, K., Stoyanov, S., & Van Maele, J. (2011, 20-21 October). Exploration of Exploitation Approaches of European Projects on ICT and Foreign Language Learning: the CEFcult project case. Paper presented at the 4th International Conference ICT for Language Learning, Florence, Italy. Available at: http://www.pixel-online.net/ICT4LL2011/conferenceproceedings.php
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ALASKA OIL AND GAS EXPLORATION, DEVELOPMENT, AND PERMITTING PROJECT
Energy Technology Data Exchange (ETDEWEB)
Richard McMahon; Robert Crandall; Chas Dense; Sean Weems
2003-08-04
The objective of this project is to eliminate three closely inter-related barriers to oil production in Alaska through the use of a geographic information system (GIS) and other information technology strategies. These barriers involve identification of oil development potential from existing wells, planning projects to efficiently avoid conflicts with other interests, and gaining state approvals for exploration and development projects. Each barrier is the result of either current labor-intensive methods or poorly accessible information. This project brings together three parts of the oil exploration, development, and permitting process to form the foundation for a more fully integrated information technology infrastructure for the State of Alaska. This web-based system will enable the public and other review participants to track permit status, submit and view comments, and obtain important project information online. By automating several functions of the current manual process, permit applications will be completed more quickly and accurately, and agencies will be able to complete reviews with fewer delays. The application will include an on-line diagnostic Coastal Project Questionnaire to determine the suite of permits required for a specific project. The application will also automatically create distribution lists based on the location and type of project, populate document templates for project review start-ups, public notices and findings, allow submission of e-comments, and post project status information on the Internet. Alaska has nearly one-quarter of the nation's supply of crude oil, at least five billion barrels of proven reserves. The American Association of Petroleum Geologists report that the 1995 National Assessment identified the North Slope as having 7.4 billion barrels of technically recoverable oil and over 63 trillion cubic feet of natural gas. From these reserves, Alaska produces roughly one-fifth of the nation's daily crude oil
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Exploring the existence and potential underpinnings of dog-human and horse-human attachment bonds.
Payne, Elyssa; DeAraugo, Jodi; Bennett, Pauleen; McGreevy, Paul
2016-04-01
This article reviews evidence for the existence of attachment bonds directed toward humans in dog-human and horse-human dyads. It explores each species' alignment with the four features of a typical attachment bond: separation-related distress, safe haven, secure base and proximity seeking. While dog-human dyads show evidence of each of these, there is limited alignment for horse-human dyads. These differences are discussed in the light of the different selection paths of domestic dogs and horses as well as the different contexts in which the two species interact with humans. The role of emotional intelligence in humans as a potential mediator for human-animal relationships, attachment or otherwise, is also examined. Finally, future studies, which may clarify the interplay between attachment, human-animal relationships and emotional intelligence, are proposed. Such avenues of research may help us explore the concepts of trust and bonding that are often said to occur at the dog-human and horse-human interface. Copyright © 2015. Published by Elsevier B.V.
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Human genetics: international projects and personalized medicine.
Apellaniz-Ruiz, Maria; Gallego, Cristina; Ruiz-Pinto, Sara; Carracedo, Angel; Rodríguez-Antona, Cristina
2016-03-01
In this article, we present the progress driven by the recent technological advances and new revolutionary massive sequencing technologies in the field of human genetics. We discuss this knowledge in relation with drug response prediction, from the germline genetic variation compiled in the 1000 Genomes Project or in the Genotype-Tissue Expression project, to the phenome-genome archives, the international cancer projects, such as The Cancer Genome Atlas or the International Cancer Genome Consortium, and the epigenetic variation and its influence in gene expression, including the regulation of drug metabolism. This review is based on the lectures presented by the speakers of the Symposium "Human Genetics: International Projects & New Technologies" from the VII Conference of the Spanish Pharmacogenetics and Pharmacogenomics Society, held on the 20th and 21st of April 2015.
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Nguyen, Hung D.; Steele, Gynelle C.
2015-01-01
This report is intended to help NASA program and project managers incorporate Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) technologies that have gone through Phase II of the SBIR program into NASA Human Exploration and Operations Mission Directorate (HEOMD) programs. Other Government and commercial project managers can also find this information useful.
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Statistical Projections for Multi-resolution, Multi-dimensional Visual Data Exploration and Analysis
Energy Technology Data Exchange (ETDEWEB)
Nguyen, Hoa T. [Univ. of Utah, Salt Lake City, UT (United States); Stone, Daithi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bethel, E. Wes [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
2016-01-01
An ongoing challenge in visual exploration and analysis of large, multi-dimensional datasets is how to present useful, concise information to a user for some specific visualization tasks. Typical approaches to this problem have proposed either reduced-resolution versions of data, or projections of data, or both. These approaches still have some limitations such as consuming high computation or suffering from errors. In this work, we explore the use of a statistical metric as the basis for both projections and reduced-resolution versions of data, with a particular focus on preserving one key trait in data, namely variation. We use two different case studies to explore this idea, one that uses a synthetic dataset, and another that uses a large ensemble collection produced by an atmospheric modeling code to study long-term changes in global precipitation. The primary findings of our work are that in terms of preserving the variation signal inherent in data, that using a statistical measure more faithfully preserves this key characteristic across both multi-dimensional projections and multi-resolution representations than a methodology based upon averaging.
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Cooperation and dialogical modeling for designing a safe Human space exploration mission to Mars
Grès, Stéphane; Tognini, Michel; Le Cardinal, Gilles; Zalila, Zyed; Gueydan, Guillaume
2014-11-01
This paper proposes an approach for a complex and innovative project requiring international contributions from different communities of knowledge and expertise. Designing a safe and reliable architecture for a manned mission to Mars or the Asteroids necessitates strong cooperation during the early stages of design to prevent and reduce risks for the astronauts at each step of the mission. The stake during design is to deal with the contradictions, antagonisms and paradoxes of the involved partners for the definition and modeling of a shared project of reference. As we see in our research which analyses the cognitive and social aspects of technological risks in major accidents, in such a project, the complexity of the global organization (during design and use) and the integration of a wide and varie d range of sciences and innovative technologies is likely to increase systemic risks as follows: human and cultural mistakes, potential defaults, failures and accidents. We identify as the main danger antiquated centralized models of organization and the operational limits of interdisciplinarity in the sciences. Beyond this, we can see that we need to take carefully into account human cooperation and the quality of relations between heterogeneous partners. Designing an open, self-learning and reliable exploration system able to self-adapt in dangerous and unforeseen situations implies a collective networked intelligence led by a safe process that organizes interaction between the actors and the aims of the project. Our work, supported by the CNES (French Space Agency), proposes an innovative approach to the coordination of a complex project.
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Learning through a Game - Exploring Fun and Learning in a Project Management Game
Hansen, Daniel Sollie; Storjord, David
2016-01-01
The goal of this thesis is to explore the teaching capabilities of games by motivating players through fun. We do this by first exploring perspectives of fun and learning in games; project management concepts and previous games. From these findings we implement our own game prototype where the player learns project management concepts simultaneously as they learn the game. This prototype is then evaluated through a number of experiments. Finally we discuss the results of the experiments and c...
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Exploring the Music Festival as a Music Educational Project
Karlsen, Sidsel; Brandstrom, Sture
2008-01-01
The purpose of this article was to explore the music festival as a music educational project by means of results drawn from a case study investigating one particular festival's impact on identity development, both for the individual member of the audience (musical identity) and for the local society (local identity). The theoretical framework was…
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The Human Genome Project: how do we protect Australians?
Stott Despoja, N
It is the moon landing of the nineties: the ambitious Human Genome Project--identifying the up to 100,000 genes that make up human DNA and the sequences of the three billion base-pairs that comprise the human genome. However, unlike the moon landing, the effects of the genome project will have a fundamental impact on the way we see ourselves and each other.
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National Aeronautics and Space Administration — The AES Water Recovery Project (WRP) is advancing environmental control and life support systems water recovery technologies to support human exploration beyond low...
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Management of Service Projects in Support of Space Flight Research
Love, J.
2009-01-01
Goal:To provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration . [HRP-47051] Specific Objectives: 1) Develop capabilities, necessary countermeasures, and technologies in support of human space exploration, focusing on mitigating the highest risks to human health and performance. 2) Define and improve human spaceflight medical, environmental, and human factors standards. 3) Develop technologies that serve to reduce medical and environmental risks, to reduce human systems resource requirements (mass, volume, power, data, etc.) and to ensure effective human-system integration across exploration systems. 4) Ensure maintenance of Agency core competencies necessary to enable risk reduction in the following areas: A. Space medicine B. Physiological and behavioral effects of long duration spaceflight on the human body C. Space environmental effects, including radiation, on human health and performance D. Space "human factors" [HRP-47051]. Service projects can form integral parts of research-based project-focused programs to provide specialized functions. Traditional/classic project management methodologies and agile approaches are not mutually exclusive paradigms. Agile strategies can be combined with traditional methods and applied in the management of service projects functioning in changing environments. Creative collaborations afford a mechanism for mitigation of constrained resource limitations.
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Cosmochemistry and Human Exploration
Taylor, G. J.
2004-12-01
About 125 scientists, engineers, business men and women, and other specialists attended the sixth meeting of the Space Resources Roundtable, held at the Colorado School of Mines in Golden, Colorado. The meeting was co-sponsored by the Space Resources Roundtable, Inc. (a nonprofit organization dedicated to the use of space resources for the benefit of humankind), the Lunar and Planetary Institute, and the Colorado School of Mines. Presentations and discussions during the meeting made it clear that the knowledge gained from cosmochemical studies of the Moon and Mars is central to devising ways to use in situ resources. This makes cosmochemistry central to the human exploration and development of space, which cannot happen without extensive in situ resource utilization (ISRU). Cosmochemists at the meeting reported on an array of topics: the nature of lunar surface materials and our lack of knowledge about surface materials in permanently shadowed regions at the lunar poles; how to make reasonable simulated lunar materials for resource extraction testbeds, vehicle design tests, and construction experiments on Earth; and how to explore for resources on the Moon and Mars.
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Human Space Exploration: The Moon, Mars, and Beyond
Sexton, Jeffrey D.
2007-01-01
America is returning to the Moon in preparation for the first human footprint on Mars, guided by the U.S. Vision for Space Exploration. This presentation will discuss NASA's mission, the reasons for returning to the Moon and going to Mars, and how NASA will accomplish that mission in ways that promote leadership in space and economic expansion on the new frontier. The primary goals of the Vision for Space Exploration are to finish the International Space Station, retire the Space Shuttle, and build the new spacecraft needed, to return people to the Moon and go to Mars. The Vision commits NASA and the nation to an agenda of exploration that also includes robotic exploration and technology development, while building on lessons learned over 50 years of hard-won experience. Why the Moon? Many questions about the Moon's potential resources and how its history is linked to that of Earth were spurred by the brief Apollo explorations of the 1960s and 1970s. This new venture will carry more explorers to more diverse landing sites with more capable tools and equipment for extended expeditions. The Moon also will serve as a training ground before embarking on the longer, more difficult trip to Mars. NASA plans to build a lunar outpost at one of the lunar poles, learn to live off the land, and reduce dePendence on Earth for longer missions. America needs to extend its ability to survive in hostile environments close to our home planet before astronauts will reach Mars, a planet very much like Earth. NASA has worked with scientists to define lunar exploration goals and is addressing the opportunities for a range of scientific study on Mars. In order to reach the Moon and Mars within a lifetime and within budget, NASA is building on common hardware, shared knowledge, and unique experience derived from the Apollo Saturn, Space Shuttle and contemporary commercial launch vehicle programs. The journeys to the Moon and Mars will require a variety of vehicles, including the Ares I
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Exploring the dynamics of ownership in community-oriented design projects
DEFF Research Database (Denmark)
Light, Ann; Hansen, Nicolai Brodersen; Halskov, Kim
2013-01-01
This paper contributes an exploration of ownership as a dynamic process in community-oriented projects. We use case study accounts of two design projects to consider participation in contexts where social structure is relevant to design outcomes. In studying these dynamics, we consider four aspec...... community groups in making internet radio podcasts to share insight. We examine the complexity of the social process involved and trace patterns of change, before concluding with pragmatic and ethical reasons for technology design to pay attention to ownership issues....
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Getting ready for the Human Phenome Project: the 2012 forum of the Human Variome Project.
Oetting, William S; Robinson, Peter N; Greenblatt, Marc S; Cotton, Richard G; Beck, Tim; Carey, John C; Doelken, Sandra C; Girdea, Marta; Groza, Tudor; Hamilton, Carol M; Hamosh, Ada; Kerner, Berit; MacArthur, Jacqueline A L; Maglott, Donna R; Mons, Barend; Rehm, Heidi L; Schofield, Paul N; Searle, Beverly A; Smedley, Damian; Smith, Cynthia L; Bernstein, Inge Thomsen; Zankl, Andreas; Zhao, Eric Y
2013-04-01
A forum of the Human Variome Project (HVP) was held as a satellite to the 2012 Annual Meeting of the American Society of Human Genetics in San Francisco, California. The theme of this meeting was "Getting Ready for the Human Phenome Project." Understanding the genetic contribution to both rare single-gene "Mendelian" disorders and more complex common diseases will require integration of research efforts among many fields and better defined phenotypes. The HVP is dedicated to bringing together researchers and research populations throughout the world to provide the resources to investigate the impact of genetic variation on disease. To this end, there needs to be a greater sharing of phenotype and genotype data. For this to occur, many databases that currently exist will need to become interoperable to allow for the combining of cohorts with similar phenotypes to increase statistical power for studies attempting to identify novel disease genes or causative genetic variants. Improved systems and tools that enhance the collection of phenotype data from clinicians are urgently needed. This meeting begins the HVP's effort toward this important goal. © 2013 Wiley Periodicals, Inc.
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Understanding predictability and exploration in human mobility
DEFF Research Database (Denmark)
Cuttone, Andrea; Jørgensen, Sune Lehmann; González, Marta C.
2018-01-01
Predictive models for human mobility have important applications in many fields including traffic control, ubiquitous computing, and contextual advertisement. The predictive performance of models in literature varies quite broadly, from over 90% to under 40%. In this work we study which underlying...... strong influence on the accuracy of prediction. Finally we reveal that the exploration of new locations is an important factor in human mobility, and we measure that on average 20-25% of transitions are to new places, and approx. 70% of locations are visited only once. We discuss how these mechanisms...... are important factors limiting our ability to predict human mobility....
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Proteogenomics Dashboard for the Human Proteome Project.
Tabas-Madrid, Daniel; Alves-Cruzeiro, Joao; Segura, Victor; Guruceaga, Elizabeth; Vialas, Vital; Prieto, Gorka; García, Carlos; Corrales, Fernando J; Albar, Juan Pablo; Pascual-Montano, Alberto
2015-09-04
dasHPPboard is a novel proteomics-based dashboard that collects and reports the experiments produced by the Spanish Human Proteome Project consortium (SpHPP) and aims to help HPP to map the entire human proteome. We have followed the strategy of analog genomics projects like the Encyclopedia of DNA Elements (ENCODE), which provides a vast amount of data on human cell lines experiments. The dashboard includes results of shotgun and selected reaction monitoring proteomics experiments, post-translational modifications information, as well as proteogenomics studies. We have also processed the transcriptomics data from the ENCODE and Human Body Map (HBM) projects for the identification of specific gene expression patterns in different cell lines and tissues, taking special interest in those genes having little proteomic evidence available (missing proteins). Peptide databases have been built using single nucleotide variants and novel junctions derived from RNA-Seq data that can be used in search engines for sample-specific protein identifications on the same cell lines or tissues. The dasHPPboard has been designed as a tool that can be used to share and visualize a combination of proteomic and transcriptomic data, providing at the same time easy access to resources for proteogenomics analyses. The dasHPPboard can be freely accessed at: http://sphppdashboard.cnb.csic.es.
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Assessing corporate project impacts in changeable contexts: A human rights perspective
Energy Technology Data Exchange (ETDEWEB)
Salcito, Kendyl, E-mail: kendyl.salcito@unibas.ch [Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel (Switzerland); University of Basel, P.O. Box, CH-4003 Basel (Switzerland); NomoGaia, 1900 Wazee Street, Suite 303, Denver, CO 80202 (United States); NewFields, LLC, Denver, CO 80202 (United States); Singer, Burton H., E-mail: bhsinger@epi.ufl.edu [Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610 (United States); Krieger, Gary R., E-mail: gkrieger@newfields.com [NewFields, LLC, Denver, CO 80202 (United States); Weiss, Mitchell G., E-mail: mitchell-g.weiss@unibas.ch [Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel (Switzerland); University of Basel, P.O. Box, CH-4003 Basel (Switzerland); Wielga, Mark, E-mail: wielga@nomogaia.org [NomoGaia, 1900 Wazee Street, Suite 303, Denver, CO 80202 (United States); NewFields, LLC, Denver, CO 80202 (United States); Utzinger, Jürg, E-mail: juerg.utzinger@unibas.ch [Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel (Switzerland); University of Basel, P.O. Box, CH-4003 Basel (Switzerland)
2014-07-01
Project-level impact assessment was originally conceived as a snapshot taken in advance of project implementation, contrasting current conditions with a likely future scenario involving a variety of predicted impacts. Current best practice guidance has encouraged a shift towards longitudinal assessments from the pre-project stage through the implementation and operating phases. Experience and study show, however, that assessment of infrastructure-intensive projects rarely endures past the project's construction phase. Negative consequences for environmental, social and health outcomes have been documented. Such consequences clarify the pressing need for longitudinal assessment in each of these domains, with human rights impact assessment (HRIA) as an umbrella over, and critical augmentation of, environmental, social and health assessments. Project impacts on human rights are more closely linked to political, economic and other factors beyond immediate effects of a company's policy and action throughout the project lifecycle. Delineating these processes requires an adequate framework, with strategies for collecting longitudinal data, protocols that provide core information for impact assessment and guidance for adaptive mitigation strategies as project-related effects change over time. This article presents general principles for the design and implementation of sustained, longitudinal HRIA, based on experience assessing and responding to human rights impact in a uranium mining project in Malawi. The case study demonstrates the value of longitudinal assessment both for limiting corporate risk and improving human welfare. - Graphical abstract: Assessing changes in human rights condition as affected by both project and context, over time. - Highlights: • Corporate capital projects affect human rights in myriad ways. • Ongoing, longitudinal impact assessment techniques are needed. • We present an approach for conducting longitudinal human rights impact
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Assessing corporate project impacts in changeable contexts: A human rights perspective
International Nuclear Information System (INIS)
Salcito, Kendyl; Singer, Burton H.; Krieger, Gary R.; Weiss, Mitchell G.; Wielga, Mark; Utzinger, Jürg
2014-01-01
Project-level impact assessment was originally conceived as a snapshot taken in advance of project implementation, contrasting current conditions with a likely future scenario involving a variety of predicted impacts. Current best practice guidance has encouraged a shift towards longitudinal assessments from the pre-project stage through the implementation and operating phases. Experience and study show, however, that assessment of infrastructure-intensive projects rarely endures past the project's construction phase. Negative consequences for environmental, social and health outcomes have been documented. Such consequences clarify the pressing need for longitudinal assessment in each of these domains, with human rights impact assessment (HRIA) as an umbrella over, and critical augmentation of, environmental, social and health assessments. Project impacts on human rights are more closely linked to political, economic and other factors beyond immediate effects of a company's policy and action throughout the project lifecycle. Delineating these processes requires an adequate framework, with strategies for collecting longitudinal data, protocols that provide core information for impact assessment and guidance for adaptive mitigation strategies as project-related effects change over time. This article presents general principles for the design and implementation of sustained, longitudinal HRIA, based on experience assessing and responding to human rights impact in a uranium mining project in Malawi. The case study demonstrates the value of longitudinal assessment both for limiting corporate risk and improving human welfare. - Graphical abstract: Assessing changes in human rights condition as affected by both project and context, over time. - Highlights: • Corporate capital projects affect human rights in myriad ways. • Ongoing, longitudinal impact assessment techniques are needed. • We present an approach for conducting longitudinal human rights impact assessment
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Exploration on the Crowdfunding Mode of Rural Memory Project
Institute of Scientific and Technical Information of China (English)
SONG Wei
2016-01-01
In the past decades of industrialization and urbanization,a plenty of Chinese villages have passed out of existence.The amount of the existing ancient villages in China only accounts for 1.9% of the amount of Chinese administrative villages.Chinese traditional villages include tangible cultural heritage like traditional residential architecture and cultural relics,as well as intangible cultural heritage like folk customs and handcraft,which are of extremely important values and demand proper conservation immediately.'Rural Memory Project' is not only a carrier project of 'memorizing nostalgia' and 'retaining passion for home',but also the original protection project of tangible cultural heritage like rural historic streets and traditional resident courtyard,as well as intangible cultural heritage like production and living customs.At present,'Rural Memory' Project launched by Shandong province was primarily funded by the government sectors whose investment was far from sufficient for the great appetite of the project,thus massive social capital has to be absorbed to ensure a sustainable implementation of the project.Featured with low threshold,strong inclusivity and stable mass basis,crowdfunding which could adapt to the characteristics of the current 'Rural Memory' Project is regarded as a feasible fund-raising channel.In the exploration of crowdfunding mode,the authorities could focus on establishing a specialized crowdfunding platform for Rural Memory Project,select proper crowdfunding mode according to the characteristics of the project,adhere to the macro orientation and policy of the government,and commit themselves to dissolving the institutional constraints in crowdfunding.
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The Dust Management Project: Final Report
Hyatt, Mark J.; Straka, Sharon
2011-01-01
A return to the Moon to extend human presence, pursue scientific activities, use the Moon to prepare for future human missions to Mars, and expand Earth s economic sphere, will require investment in developing new technologies and capabilities to achieve affordable and sustainable human exploration. From the operational experience gained and lessons learned during the Apollo missions, conducting longterm operations in the lunar environment will be a particular challenge, given the difficulties presented by the unique physical properties and other characteristics of lunar regolith, including dust. The Apollo missions and other lunar explorations have identified significant lunar dust-related problems that will challenge future mission success. Comprised of regolith particles ranging in size from tens of nanometers to microns, lunar dust is a manifestation of the complex interaction of the lunar soil with multiple mechanical, electrical, and gravitational effects. The environmental and anthropogenic factors effecting the perturbation, transport, and deposition of lunar dust must be studied in order to mitigate it s potentially harmful effects on exploration systems and human explorers. The Dust Management Project (DMP) is tasked with the evaluation of lunar dust effects, assessment of the resulting risks, and development of mitigation and management strategies and technologies related to Exploration Systems architectures. To this end, the DMP supports the overall goal of the Exploration Technology Development Program (ETDP) of addressing the relevant high priority technology needs of multiple elements within the Constellation Program (CxP) and sister ETDP projects. Project scope, approach, accomplishments, summary of deliverables, and lessons learned are presented.
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Towards human exploration of space: The THESEUS review series on immunology research priorities.
Frippiat, Jean-Pol; Crucian, Brian E; de Quervain, Dominique J-F; Grimm, Daniela; Montano, Nicola; Praun, Siegfried; Roozendaal, Benno; Schelling, Gustav; Thiel, Manfred; Ullrich, Oliver; Choukèr, Alexander
2016-01-01
Dysregulation of the immune system occurs during spaceflight and may represent a crew health risk during exploration missions because astronauts are challenged by many stressors. Therefore, it is crucial to understand the biology of immune modulation under spaceflight conditions in order to be able to maintain immune homeostasis under such challenges. In the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration, experts working in the field of space immunology, and related disciplines, established a questionnaire sent to scientists around the world. From the review of collected answers, they deduced a list of key issues and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space, and to increase increments duration for some ISS crew members to 12 months or longer. These recommendations should contribute to improve our knowledge about spaceflight effects on the immune system and the development of countermeasures that, beyond astronauts, could have a societal impact.
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Comparison of Propulsion Options for Human Exploration of Mars
Drake, Bret G.; McGuire, Melissa L.; McCarty, Steven L.
2018-01-01
NASA continues to advance plans to extend human presence beyond low-Earth orbit leading to human exploration of Mars. The plans being laid out follow an incremental path, beginning with initial flight tests followed by deployment of a Deep Space Gateway (DSG) in cislunar space. This Gateway, will serve as the initial transportation node for departing and returning Mars spacecraft. Human exploration of Mars represents the next leap for humankind because it will require leaving Earth on a long mission with very limited return, rescue, or resupply capabilities. Although Mars missions are long, approaches and technologies are desired which can reduce the time that the crew is away from Earth. This paper builds off past analyses of NASA's exploration strategy by providing more detail on the performance of alternative in-space transportation options with an emphasis on reducing total mission duration. Key options discussed include advanced chemical, nuclear thermal, nuclear electric, solar electric, as well as an emerging hybrid propulsion system which utilizes a combination of both solar electric and chemical propulsion.
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Human genomics projects and precision medicine.
Carrasco-Ramiro, F; Peiró-Pastor, R; Aguado, B
2017-09-01
The completion of the Human Genome Project (HGP) in 2001 opened the floodgates to a deeper understanding of medicine. There are dozens of HGP-like projects which involve from a few tens to several million genomes currently in progress, which vary from having specialized goals or a more general approach. However, data generation, storage, management and analysis in public and private cloud computing platforms have raised concerns about privacy and security. The knowledge gained from further research has changed the field of genomics and is now slowly permeating into clinical medicine. The new precision (personalized) medicine, where genome sequencing and data analysis are essential components, allows tailored diagnosis and treatment according to the information from the patient's own genome and specific environmental factors. P4 (predictive, preventive, personalized and participatory) medicine is introducing new concepts, challenges and opportunities. This review summarizes current sequencing technologies, concentrates on ongoing human genomics projects, and provides some examples in which precision medicine has already demonstrated clinical impact in diagnosis and/or treatment.
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Human Activity Recognition in AAL Environments Using Random Projections
Directory of Open Access Journals (Sweden)
Robertas Damaševičius
2016-01-01
Full Text Available Automatic human activity recognition systems aim to capture the state of the user and its environment by exploiting heterogeneous sensors attached to the subject’s body and permit continuous monitoring of numerous physiological signals reflecting the state of human actions. Successful identification of human activities can be immensely useful in healthcare applications for Ambient Assisted Living (AAL, for automatic and intelligent activity monitoring systems developed for elderly and disabled people. In this paper, we propose the method for activity recognition and subject identification based on random projections from high-dimensional feature space to low-dimensional projection space, where the classes are separated using the Jaccard distance between probability density functions of projected data. Two HAR domain tasks are considered: activity identification and subject identification. The experimental results using the proposed method with Human Activity Dataset (HAD data are presented.
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Human Activity Recognition in AAL Environments Using Random Projections.
Damaševičius, Robertas; Vasiljevas, Mindaugas; Šalkevičius, Justas; Woźniak, Marcin
2016-01-01
Automatic human activity recognition systems aim to capture the state of the user and its environment by exploiting heterogeneous sensors attached to the subject's body and permit continuous monitoring of numerous physiological signals reflecting the state of human actions. Successful identification of human activities can be immensely useful in healthcare applications for Ambient Assisted Living (AAL), for automatic and intelligent activity monitoring systems developed for elderly and disabled people. In this paper, we propose the method for activity recognition and subject identification based on random projections from high-dimensional feature space to low-dimensional projection space, where the classes are separated using the Jaccard distance between probability density functions of projected data. Two HAR domain tasks are considered: activity identification and subject identification. The experimental results using the proposed method with Human Activity Dataset (HAD) data are presented.
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Burn, John; Watson, Michael
2016-06-01
The practical realization of genomics has meant a growing realization that variant interpretation is a major barrier to practical use of DNA sequence data. The late Professor Dick Cotton devoted his life to innovation in molecular genetics and was a prime mover in the international response to the need to understand the "variome." His leadership resulted in the launch first of the Human Genetic Variation Society and then, in 2006, an international agreement to launch the Human Variome Project (HVP), aimed at data integration enabled by standards and infrastructure of the databases of variants being identified in families with a range of inherited disorders. The project attracted a network of affiliates across 81 countries and earned formal recognition by UNESCO, which now hosts its biennial meetings. It has also signed a Memorandum of Understanding with the World Health Organization. Future progress will depend on longer term secure funding and integration with the efforts of the genomics community where the rapid advances in sequencing technology have enabled variant capture on a previously unimaginable scale. Efforts are underway to integrate the efforts of HVP with those of the Global Alliance for Genomics and Health to provide a lasting legacy of Dick Cotton's vision. © 2016 WILEY PERIODICALS, INC.
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Concept Design of High Power Solar Electric Propulsion Vehicles for Human Exploration
Hoffman, David J.; Kerslake, Thomas W.; Hojnicki, Jeffrey S.; Manzella, David H.; Falck, Robert D.; Cikanek, Harry A., III; Klem, Mark D.; Free, James M.
2011-01-01
Human exploration beyond low Earth orbit will require enabling capabilities that are efficient, affordable and reliable. Solar electric propulsion (SEP) has been proposed by NASA s Human Exploration Framework Team as one option to achieve human exploration missions beyond Earth orbit because of its favorable mass efficiency compared to traditional chemical propulsion systems. This paper describes the unique challenges associated with developing a large-scale high-power (300-kWe class) SEP vehicle and design concepts that have potential to meet those challenges. An assessment of factors at the subsystem level that must be considered in developing an SEP vehicle for future exploration missions is presented. Overall concepts, design tradeoffs and pathways to achieve development readiness are discussed.
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Planning the Human Variome Project: The Spain Report†
Kaput, Jim; Cotton, Richard G. H.; Hardman, Lauren; Al Aqeel, Aida I.; Al-Aama, Jumana Y.; Al-Mulla, Fahd; Aretz, Stefan; Auerbach, Arleen D.; Axton, Myles; Bapat, Bharati; Bernstein, Inge T.; Bhak, Jong; Bleoo, Stacey L.; Blöcker, Helmut; Brenner, Steven E.; Burn, John; Bustamante, Mariona; Calzone, Rita; Cambon-Thomsen, Anne; Cargill, Michele; Carrera, Paola; Cavedon, Lawrence; Cho, Yoon Shin; Chung, Yeun-Jun; Claustres, Mireille; Cutting, Garry; Dalgleish, Raymond; den Dunnen, Johan T.; Díaz, Carlos; Dobrowolski, Steven; dos Santos, M. Rosário N.; Ekong, Rosemary; Flanagan, Simon B.; Flicek, Paul; Furukawa, Yoichi; Genuardi, Maurizio; Ghang, Ho; Golubenko, Maria V.; Greenblatt, Marc S.; Hamosh, Ada; Hancock, John M.; Hardison, Ross; Harrison, Terence M.; Hoffmann, Robert; Horaitis, Rania; Howard, Heather J.; Barash, Carol Isaacson; Izagirre, Neskuts; Jung, Jongsun; Kojima, Toshio; Laradi, Sandrine; Lee, Yeon-Su; Lee, Jong-Young; Gil-da-Silva-Lopes, Vera L.; Macrae, Finlay A.; Maglott, Donna; Marafie, Makia J.; Marsh, Steven G.E.; Matsubara, Yoichi; Messiaen, Ludwine M.; Möslein, Gabriela; Netea, Mihai G.; Norton, Melissa L.; Oefner, Peter J.; Oetting, William S.; O’Leary, James C.; de Ramirez, Ana Maria Oller; Paalman, Mark H.; Parboosingh, Jillian; Patrinos, George P.; Perozzi, Giuditta; Phillips, Ian R.; Povey, Sue; Prasad, Suyash; Qi, Ming; Quin, David J.; Ramesar, Rajkumar S.; Richards, C. Sue; Savige, Judith; Scheible, Dagmar G.; Scott, Rodney J.; Seminara, Daniela; Shephard, Elizabeth A.; Sijmons, Rolf H.; Smith, Timothy D.; Sobrido, María-Jesús; Tanaka, Toshihiro; Tavtigian, Sean V.; Taylor, Graham R.; Teague, Jon; Töpel, Thoralf; Ullman-Cullere, Mollie; Utsunomiya, Joji; van Kranen, Henk J.; Vihinen, Mauno; Watson, Michael; Webb, Elizabeth; Weber, Thomas K.; Yeager, Meredith; Yeom, Young I.; Yim, Seon-Hee; Yoo, Hyang-Sook
2018-01-01
The remarkable progress in characterizing the human genome sequence, exemplified by the Human Genome Project and the HapMap Consortium, has led to the perception that knowledge and the tools (e.g., microarrays) are sufficient for many if not most biomedical research efforts. A large amount of data from diverse studies proves this perception inaccurate at best, and at worst, an impediment for further efforts to characterize the variation in the human genome. Since variation in genotype and environment are the fundamental basis to understand phenotypic variability and heritability at the population level, identifying the range of human genetic variation is crucial to the development of personalized nutrition and medicine. The Human Variome Project (HVP; http://www.humanvariomeproject.org/) was proposed initially to systematically collect mutations that cause human disease and create a cyber infrastructure to link locus specific databases (LSDB). We report here the discussions and recommendations from the 2008 HVP planning meeting held in San Feliu de Guixols, Spain, in May 2008. PMID:19306394
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Grgurina, Natasa; van Veen, Klaas; Barendsen, Erik; Zwaneveld, Bert; Suhre, Cor; Gal-Ezer, Judith; Sentance, Sue; Vahrenhold, Jan
2015-01-01
Computational Thinking (CT) is gaining a lot of attention in education. We explored how to discern the occurrences of CT in the projects of 12th grade high school students in the computer science (CS) course. Within the projects, they constructed models and ran simulations of phenomena from other
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Advanced Life Support Project Plan
2002-01-01
Life support systems are an enabling technology and have become integral to the success of living and working in space. As NASA embarks on human exploration and development of space to open the space frontier by exploring, using and enabling the development of space and to expand the human experience into the far reaches of space, it becomes imperative, for considerations of safety, cost, and crew health, to minimize consumables and increase the autonomy of the life support system. Utilizing advanced life support technologies increases this autonomy by reducing mass, power, and volume necessary for human support, thus permitting larger payload allocations for science and exploration. Two basic classes of life support systems must be developed, those directed toward applications on transportation/habitation vehicles (e.g., Space Shuttle, International Space Station (ISS), next generation launch vehicles, crew-tended stations/observatories, planetary transit spacecraft, etc.) and those directed toward applications on the planetary surfaces (e.g., lunar or Martian landing spacecraft, planetary habitats and facilities, etc.). In general, it can be viewed as those systems compatible with microgravity and those compatible with hypogravity environments. Part B of the Appendix defines the technology development 'Roadmap' to be followed in providing the necessary systems for these missions. The purpose of this Project Plan is to define the Project objectives, Project-level requirements, the management organizations responsible for the Project throughout its life cycle, and Project-level resources, schedules and controls.
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Science Driven Human Exploration of Mars
McKay, Christopher P.
2004-01-01
Mars appears to be cold dry and dead world. However there is good evidence that early in its history it had liquid water, more active volcanism, and a thicker atmosphere. Mars had this earth-like environment over three and a half billion years ago, during the same time that life appeared on Earth. The main question in the exploration of Mars then is the search for a independent origin of life on that planet. Ecosystems in cold, dry locations on Earth - such as the Antarctic - provide examples of how life on Mars might have survived and where to look for fossils. Fossils are not enough. We will want to determine if life on Mars was a separate genesis from life on Earth. For this determination we need to access intact martian life; possibly frozen in the deep old permafrost. Human exploration of Mars will probably begin with a small base manned by a temporary crew, a necessary first start. But exploration of the entire planet will require a continued presence on the Martian surface and the development of a self sustaining community in which humans can live and work for very long periods of time. A permanent Mars research base can be compared to the permanent research bases which several nations maintain in Antarctica at the South Pole, the geomagnetic pole, and elsewhere. In the long run, a continued human presence on Mars will be the most economical way to study that planet in detail. It is possible that at some time in the future we might recreate a habitable climate on Mars, returning it to the life-bearing state it may have enjoyed early in its history. Our studies of Mars are still in a preliminary state but everything we have learned suggests that it may be possible to restore Mars to a habitable climate. Additional information is contained in the original extended abstract.
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Getting Ready for the Human Phenome Project
DEFF Research Database (Denmark)
Oetting, William S; Robinson, Peter N; Greenblatt, Marc S
2013-01-01
A forum of the Human Variome Project (HVP) was held as a satellite to the 2012 Annual Meeting of the American Society of Human Genetics in San Francisco, California. The theme of this meeting was "Getting Ready for the Human Phenome Project". Understanding the genetic contribution to both rare si...... for studies attempting to identify novel disease genes or causative genetic variants. Improved systems and tools that enhance the collection of phenotype data from clinicians are urgently needed. This meeting begins the HVP's effort towards this important goal....... the impact of genetic variation on disease. To this end, there needs to be a greater sharing of phenotype and genotype data. For this to occur, the many databases that currently exist will need to become interoperable to allow for the combining of cohorts with similar phenotypes to increase statistical power...
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Strategic Implications of Human Exploration of Near-Earth Asteroids
Drake, Bret G.
2011-01-01
The current United States Space Policy [1] as articulated by the White House and later confirmed by the Congress [2] calls for [t]he extension of the human presence from low-Earth orbit to other regions of space beyond low-Earth orbit will enable missions to the surface of the Moon and missions to deep space destinations such as near-Earth asteroids and Mars. Human exploration of the Moon and Mars has been the focus of numerous exhaustive studies and planning, but missions to Near-Earth Asteroids (NEAs) has, by comparison, garnered relatively little attention in terms of mission and systems planning. This paper examines the strategic implications of human exploration of NEAs and how they can fit into the overall exploration strategy. This paper specifically addresses how accessible NEAs are in terms of mission duration, technologies required, and overall architecture construct. Example mission architectures utilizing different propulsion technologies such as chemical, nuclear thermal, and solar electric propulsion were formulated to determine resulting figures of merit including number of NEAs accessible, time of flight, mission mass, number of departure windows, and length of the launch windows. These data, in conjunction with what we currently know about these potential exploration targets (or need to know in the future), provide key insights necessary for future mission and strategic planning.
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Comparison of Human Exploration Architecture and Campaign Approaches
Goodliff, Kandyce; Cirillo, William; Mattfeld, Bryan; Stromgren, Chel; Shyface, Hilary
2015-01-01
As part of an overall focus on space exploration, National Aeronautics and Space Administration (NASA) continues to evaluate potential approaches for sending humans beyond low Earth orbit (LEO). In addition, various external organizations are studying options for beyond LEO exploration. Recent studies include NASA's Evolvable Mars Campaign and Design Reference Architecture (DRA) 5.0, JPL's Minimal Mars Architecture; the Inspiration Mars mission; the Mars One campaign; and the Global Exploration Roadmap (GER). Each of these potential exploration constructs applies unique methods, architectures, and philosophies for human exploration. It is beneficial to compare potential approaches in order to better understand the range of options available for exploration. Since most of these studies were conducted independently, the approaches, ground rules, and assumptions used to conduct the analysis differ. In addition, the outputs and metrics presented for each construct differ substantially. This paper will describe the results of an effort to compare and contrast the results of these different studies under a common set of metrics. The paper will first present a summary of each of the proposed constructs, including a description of the overall approach and philosophy for exploration. Utilizing a common set of metrics for comparison, the paper will present the results of an evaluation of the potential benefits, critical challenges, and uncertainties associated with each construct. The analysis framework will include a detailed evaluation of key characteristics of each construct. These will include but are not limited to: a description of the technology and capability developments required to enable the construct and the uncertainties associated with these developments; an analysis of significant operational and programmatic risks associated with that construct; and an evaluation of the extent to which exploration is enabled by the construct, including the destinations
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Discrete event simulation of NASA's Remote Exploration and Experimentation Project (REE)
Dunphy, J.; Rogstad, S.
2001-01-01
The Remote Exploration and Experimentation Project (REE) is a new initiative at JPL to be able to place a supercomputer on board a spacecraft and allow large amounts of data reduction and compression to be done before science results are returned to Earth.
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Project Icarus: Stakeholder Scenarios for an Interstellar Exploration Program
Hein, A. M.; Tziolas, A. C.; Osborne, R.
The Project Icarus Study Group's objective is to design a mainly fusion-propelled interstellar probe. The starting point are the results of the Daedalus study, which was conducted by the British Interplanetary Society during the 1970's. As the Daedalus study already indicated, interstellar probes will be the result of a large scale, decade-long development program. To sustain a program over such long periods, the commitment of key stakeholders is vital. Although previous publications identified political and societal preconditions to an interstellar exploration program, there is a lack of more specific scientific and political stakeholder scenarios. This paper develops stakeholder scenarios which allow for a more detailed sustainability assessment of future programs. For this purpose, key stakeholder groups and their needs are identified and scientific and political scenarios derived. Political scenarios are based on patterns of past space programs but unprecedented scenarios are considered as well. Although it is very difficult to sustain an interstellar exploration program, there are scenarios in which this seems to be possible, e.g. the discovery of life within the solar system and on an exoplanet, a global technology development program, and dual-use of technologies for defence and security purposes. This is a submission of the Project Icarus Study Group.
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Rhodes, Bradley; Meck, Janice
2005-01-01
NASA s National Vision for Space Exploration includes human travel beyond low earth orbit and the ultimate safe return of the crews. Crucial to fulfilling the vision is the successful and timely development of countermeasures for the adverse physiological effects on human systems caused by long term exposure to the microgravity environment. Limited access to in-flight resources for the foreseeable future increases NASA s reliance on ground-based analogs to simulate these effects of microgravity. The primary analog for human based research will be head-down bed rest. By this approach NASA will be able to evaluate countermeasures in large sample sizes, perform preliminary evaluations of proposed in-flight protocols and assess the utility of individual or combined strategies before flight resources are requested. In response to this critical need, NASA has created the Bed Rest Project at the Johnson Space Center. The Project establishes the infrastructure and processes to provide a long term capability for standardized domestic bed rest studies and countermeasure development. The Bed Rest Project design takes a comprehensive, interdisciplinary, integrated approach that reduces the resource overhead of one investigator for one campaign. In addition to integrating studies operationally relevant for exploration, the Project addresses other new Vision objectives, namely: 1) interagency cooperation with the NIH allows for Clinical Research Center (CRC) facility sharing to the benefit of both agencies, 2) collaboration with our International Partners expands countermeasure development opportunities for foreign and domestic investigators as well as promotes consistency in approach and results, 3) to the greatest degree possible, the Project also advances research by clinicians and academia alike to encourage return to earth benefits. This paper will describe the Project s top level goals, organization and relationship to other Exploration Vision Projects, implementation
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The Human Genome Project: Information access, management, and regulation. Final report
Energy Technology Data Exchange (ETDEWEB)
McInerney, J.D.; Micikas, L.B.
1996-08-31
The Human Genome Project is a large, internationally coordinated effort in biological research directed at creating a detailed map of human DNA. This report describes the access of information, management, and regulation of the project. The project led to the development of an instructional module titled The Human Genome Project: Biology, Computers, and Privacy, designed for use in high school biology classes. The module consists of print materials and both Macintosh and Windows versions of related computer software-Appendix A contains a copy of the print materials and discs containing the two versions of the software.
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Human Space Exploration and Human Space Flight: Latency and the Cognitive Scale of the Universe
Lester, Dan; Thronson, Harley
2011-01-01
The role of telerobotics in space exploration as placing human cognition on other worlds is limited almost entirely by the speed of light, and the consequent communications latency that results from large distances. This latency is the time delay between the human brain at one end, and the telerobotic effector and sensor at the other end. While telerobotics and virtual presence is a technology that is rapidly becoming more sophisticated, with strong commercial interest on the Earth, this time delay, along with the neurological timescale of a human being, quantitatively defines the cognitive horizon for any locale in space. That is, how distant can an operator be from a robot and not be significantly impacted by latency? We explore that cognitive timescale of the universe, and consider the implications for telerobotics, human space flight, and participation by larger numbers of people in space exploration. We conclude that, with advanced telepresence, sophisticated robots could be operated with high cognition throughout a lunar hemisphere by astronauts within a station at an Earth-Moon Ll or L2 venue. Likewise, complex telerobotic servicing of satellites in geosynchronous orbit can be carried out from suitable terrestrial stations.
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Planning the human variome project: the Spain report.
Kaput, Jim; Cotton, Richard G H; Hardman, Lauren; Watson, Michael; Al Aqeel, Aida I; Al-Aama, Jumana Y; Al-Mulla, Fahd; Alonso, Santos; Aretz, Stefan; Auerbach, Arleen D; Bapat, Bharati; Bernstein, Inge T; Bhak, Jong; Bleoo, Stacey L; Blöcker, Helmut; Brenner, Steven E; Burn, John; Bustamante, Mariona; Calzone, Rita; Cambon-Thomsen, Anne; Cargill, Michele; Carrera, Paola; Cavedon, Lawrence; Cho, Yoon Shin; Chung, Yeun-Jun; Claustres, Mireille; Cutting, Garry; Dalgleish, Raymond; den Dunnen, Johan T; Díaz, Carlos; Dobrowolski, Steven; dos Santos, M Rosário N; Ekong, Rosemary; Flanagan, Simon B; Flicek, Paul; Furukawa, Yoichi; Genuardi, Maurizio; Ghang, Ho; Golubenko, Maria V; Greenblatt, Marc S; Hamosh, Ada; Hancock, John M; Hardison, Ross; Harrison, Terence M; Hoffmann, Robert; Horaitis, Rania; Howard, Heather J; Barash, Carol Isaacson; Izagirre, Neskuts; Jung, Jongsun; Kojima, Toshio; Laradi, Sandrine; Lee, Yeon-Su; Lee, Jong-Young; Gil-da-Silva-Lopes, Vera L; Macrae, Finlay A; Maglott, Donna; Marafie, Makia J; Marsh, Steven G E; Matsubara, Yoichi; Messiaen, Ludwine M; Möslein, Gabriela; Netea, Mihai G; Norton, Melissa L; Oefner, Peter J; Oetting, William S; O'Leary, James C; de Ramirez, Ana Maria Oller; Paalman, Mark H; Parboosingh, Jillian; Patrinos, George P; Perozzi, Giuditta; Phillips, Ian R; Povey, Sue; Prasad, Suyash; Qi, Ming; Quin, David J; Ramesar, Rajkumar S; Richards, C Sue; Savige, Judith; Scheible, Dagmar G; Scott, Rodney J; Seminara, Daniela; Shephard, Elizabeth A; Sijmons, Rolf H; Smith, Timothy D; Sobrido, María-Jesús; Tanaka, Toshihiro; Tavtigian, Sean V; Taylor, Graham R; Teague, Jon; Töpel, Thoralf; Ullman-Cullere, Mollie; Utsunomiya, Joji; van Kranen, Henk J; Vihinen, Mauno; Webb, Elizabeth; Weber, Thomas K; Yeager, Meredith; Yeom, Young I; Yim, Seon-Hee; Yoo, Hyang-Sook
2009-04-01
The remarkable progress in characterizing the human genome sequence, exemplified by the Human Genome Project and the HapMap Consortium, has led to the perception that knowledge and the tools (e.g., microarrays) are sufficient for many if not most biomedical research efforts. A large amount of data from diverse studies proves this perception inaccurate at best, and at worst, an impediment for further efforts to characterize the variation in the human genome. Because variation in genotype and environment are the fundamental basis to understand phenotypic variability and heritability at the population level, identifying the range of human genetic variation is crucial to the development of personalized nutrition and medicine. The Human Variome Project (HVP; http://www.humanvariomeproject.org/) was proposed initially to systematically collect mutations that cause human disease and create a cyber infrastructure to link locus specific databases (LSDB). We report here the discussions and recommendations from the 2008 HVP planning meeting held in San Feliu de Guixols, Spain, in May 2008. (c) 2009 Wiley-Liss, Inc.
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Human activity and climate variability project - annual report 2002
International Nuclear Information System (INIS)
Chambers, S.; Harle, K.J.; Sharmeen, S.; Zahorowski, W.; Cohen, D.; Heijnis, H.; Henderson-Sellers, A
2002-01-01
Work is well underway on identifying the spatial and temporal extent, direction and range of trace element transport across Tasmania through analysis of lake sediments; A follow up investigation of sedimentation and pollution in the Nattai River catchment following the devastating 2001 bushfires in the region has been completed; The project has been extended to include investigations of evidence of human impacts in the highly sensitive and ecologically important Great Lakes of coastal NSW. This has involved the expansion of our collaboration to include Geoscience Australia; Contributions have been made to the IGBP HITE project. Further contributions will be made as the evidence gathered is drawn together and interpreted; Over the coming year, focus will be placed on completion of the investigation of the extent of aerial transport of trace elements across Tasmania over the last 200 years as well as evidence for human activity and impacts on the Great Lakes region of NSW. Further investigation of potential climate signals from sites in northern Australia will also be made. The first 12 months of data for all ACE-Asia radon and fine particle sites is now available with preliminary analyses performed; The seasonal variability of background radon concentration at each of the radon monitoring sites has been characterised for the available data; Major components related to industrial pollution and soil sources in China have been identified and quantified; Regional and seasonal variations and trends in aerosol constituents have been measured and compared across more than 2.8Mk 2 of sampling area; The Hok Tsui and Kosan detectors were visited for general maintenance and recalibration; A grant application to the APN has been submitted in support of regional inventory analyses based on radon time series; Progress on the processing and interpretation of radon data was presented at the Cape Grim Science Meeting (6-7 February 2002) and the 7th Biennial SPERA Conference on
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Human activity and climate variability project - annual report 2002
Energy Technology Data Exchange (ETDEWEB)
Chambers, S; Harle, K J; Sharmeen, S; Zahorowski, W; Cohen, D; Heijnis, H; Henderson-Sellers, A [Australian Nuclear Science and Technology Organisation, Menai, NSW (Australia)
2002-07-01
Work is well underway on identifying the spatial and temporal extent, direction and range of trace element transport across Tasmania through analysis of lake sediments; A follow up investigation of sedimentation and pollution in the Nattai River catchment following the devastating 2001 bushfires in the region has been completed; The project has been extended to include investigations of evidence of human impacts in the highly sensitive and ecologically important Great Lakes of coastal NSW. This has involved the expansion of our collaboration to include Geoscience Australia; Contributions have been made to the IGBP HITE project. Further contributions will be made as the evidence gathered is drawn together and interpreted; Over the coming year, focus will be placed on completion of the investigation of the extent of aerial transport of trace elements across Tasmania over the last 200 years as well as evidence for human activity and impacts on the Great Lakes region of NSW. Further investigation of potential climate signals from sites in northern Australia will also be made. The first 12 months of data for all ACE-Asia radon and fine particle sites is now available with preliminary analyses performed; The seasonal variability of background radon concentration at each of the radon monitoring sites has been characterised for the available data; Major components related to industrial pollution and soil sources in China have been identified and quantified; Regional and seasonal variations and trends in aerosol constituents have been measured and compared across more than 2.8Mk{sup 2} of sampling area; The Hok Tsui and Kosan detectors were visited for general maintenance and recalibration; A grant application to the APN has been submitted in support of regional inventory analyses based on radon time series; Progress on the processing and interpretation of radon data was presented at the Cape Grim Science Meeting (6-7 February 2002) and the 7th Biennial SPERA Conference on
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Composites for Exploration Upper Stage
Fikes, J. C.; Jackson, J. R.; Richardson, S. W.; Thomas, A. D.; Mann, T. O.; Miller, S. G.
2016-01-01
The Composites for Exploration Upper Stage (CEUS) was a 3-year, level III project within the Technology Demonstration Missions program of the NASA Space Technology Mission Directorate. Studies have shown that composites provide important programmatic enhancements, including reduced weight to increase capability and accelerated expansion of exploration and science mission objectives. The CEUS project was focused on technologies that best advanced innovation, infusion, and broad applications for the inclusion of composites on future large human-rated launch vehicles and spacecraft. The benefits included near- and far-term opportunities for infusion (NASA, industry/commercial, Department of Defense), demonstrated critical technologies and technically implementable evolvable innovations, and sustained Agency experience. The initial scope of the project was to advance technologies for large composite structures applicable to the Space Launch System (SLS) Exploration Upper Stage (EUS) by focusing on the affordability and technical performance of the EUS forward and aft skirts. The project was tasked to develop and demonstrate critical composite technologies with a focus on full-scale materials, design, manufacturing, and test using NASA in-house capabilities. This would have demonstrated a major advancement in confidence and matured the large-scale composite technology to a Technology Readiness Level 6. This project would, therefore, have bridged the gap for providing composite application to SLS upgrades, enabling future exploration missions.
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A bioinformatics roadmap for the human vaccines project.
Scheuermann, Richard H; Sinkovits, Robert S; Schenkelberg, Theodore; Koff, Wayne C
2017-06-01
Biomedical research has become a data intensive science in which high throughput experimentation is producing comprehensive data about biological systems at an ever-increasing pace. The Human Vaccines Project is a new public-private partnership, with the goal of accelerating development of improved vaccines and immunotherapies for global infectious diseases and cancers by decoding the human immune system. To achieve its mission, the Project is developing a Bioinformatics Hub as an open-source, multidisciplinary effort with the overarching goal of providing an enabling infrastructure to support the data processing, analysis and knowledge extraction procedures required to translate high throughput, high complexity human immunology research data into biomedical knowledge, to determine the core principles driving specific and durable protective immune responses.
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Space Mission Human Reliability Analysis (HRA) Project
Boyer, Roger
2014-01-01
The purpose of the Space Mission Human Reliability Analysis (HRA) Project is to extend current ground-based HRA risk prediction techniques to a long-duration, space-based tool. Ground-based HRA methodology has been shown to be a reasonable tool for short-duration space missions, such as Space Shuttle and lunar fly-bys. However, longer-duration deep-space missions, such as asteroid and Mars missions, will require the crew to be in space for as long as 400 to 900 day missions with periods of extended autonomy and self-sufficiency. Current indications show higher risk due to fatigue, physiological effects due to extended low gravity environments, and others, may impact HRA predictions. For this project, Safety & Mission Assurance (S&MA) will work with Human Health & Performance (HH&P) to establish what is currently used to assess human reliabiilty for human space programs, identify human performance factors that may be sensitive to long duration space flight, collect available historical data, and update current tools to account for performance shaping factors believed to be important to such missions. This effort will also contribute data to the Human Performance Data Repository and influence the Space Human Factors Engineering research risks and gaps (part of the HRP Program). An accurate risk predictor mitigates Loss of Crew (LOC) and Loss of Mission (LOM).The end result will be an updated HRA model that can effectively predict risk on long-duration missions.
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A Situation Awareness Assistant for Human Deep Space Exploration
Boy, Guy A.; Platt, Donald
2013-01-01
This paper presents the development and testing of a Virtual Camera (VC) system to improve astronaut and mission operations situation awareness while exploring other planetary bodies. In this embodiment, the VC is implemented using a tablet-based computer system to navigate through inter active database application. It is claimed that the advanced interaction media capability of the VC can improve situation awareness as the distribution of hu man space exploration roles change in deep space exploration. The VC is being developed and tested for usability and capability to improve situation awareness. Work completed thus far as well as what is needed to complete the project will be described. Planned testing will also be described.
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Human-Robot Teamwork in USAR Environments: The TRADR Project
Greeff, J. de; Hindriks, K.; Neerincx, M.A.; Kruijff-Korbayova, I.
2015-01-01
The TRADR project aims at developing methods and models for human-robot teamwork, enabling robots to operate in search and rescue environments alongside humans as teammates, rather than as tools. Through a user-centered cognitive engineering method, human-robot teamwork is analyzed, modeled,
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Peer-to-Peer Human-Robot Interaction for Space Exploration
Fong, Terrence; Nourbakhsh, Illah
2004-01-01
NASA has embarked on a long-term program to develop human-robot systems for sustained, affordable space exploration. To support this mission, we are working to improve human-robot interaction and performance on planetary surfaces. Rather than building robots that function as glorified tools, our focus is to enable humans and robots to work as partners and peers. In this paper. we describe our approach, which includes contextual dialogue, cognitive modeling, and metrics-based field testing.
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NASA Advanced Exploration Systems: Advancements in Life Support Systems
Shull, Sarah A.; Schneider, Walter F.
2016-01-01
The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions assessed by NASA’s Habitability Architecture Team.
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Human Research Program: Space Human Factors and Habitability Element
Russo, Dane M.
2007-01-01
The three project areas of the Space Human Factors and Habitability Element work together to achieve a working and living environment that will keep crews healthy, safe, and productive throughout all missions -- from Earth orbit to Mars expeditions. The Advanced Environmental Health (AEH) Project develops and evaluates advanced habitability systems and establishes requirements and health standards for exploration missions. The Space Human Factors Engineering (SHFE) Project s goal is to ensure a safe and productive environment for humans in space. With missions using new technologies at an ever-increasing rate, it is imperative that these advances enhance crew performance without increasing stress or risk. The ultimate goal of Advanced Food Technology (AFT) Project is to develop and deliver technologies for human centered spacecraft that will support crews on missions to the moon, Mars, and beyond.
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Aliakbargolkar, Alessandro; Crawley, Edward F.
2014-01-01
The current debate in the U.S. Human Spaceflight Program focuses on the development of the next generation of man-rated heavy lift launch vehicles. While launch vehicle systems are of critical importance for future exploration, a comprehensive analysis of the entire exploration infrastructure is required to avoid costly pitfalls at early stages of the design process. This paper addresses this need by presenting a Delphi-Based Systems Architecting Framework for integrated architectural analysis of future in-orbit infrastructure for human space exploration beyond Low Earth Orbit. The paper is structured in two parts. The first part consists of an expert elicitation study to identify objectives for the in-space transportation infrastructure. The study was conducted between November 2011 and January 2012 with 15 senior experts involved in human spaceflight in the United States and Europe. The elicitation study included the formation of three expert panels representing exploration, science, and policy stakeholders engaged in a 3-round Delphi study. The rationale behind the Delphi approach, as imported from social science research, is discussed. Finally, a novel version of the Delphi method is presented and applied to technical decision-making and systems architecting in the context of human space exploration. The second part of the paper describes a tradespace exploration study of in-orbit infrastructure coupled with a requirements definition exercise informed by expert elicitation. The uncertainties associated with technical requirements and stakeholder goals are explicitly considered in the analysis. The outcome of the expert elicitation process portrays an integrated view of perceived stakeholder needs within the human spaceflight community. Needs are subsequently converted into requirements and coupled to the system architectures of interest to analyze the correlation between exploration, science, and policy goals. Pareto analysis is used to identify architectures
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The Qumran Visualization Project: Prospects for Digital Humanities in Theological Libraries
Directory of Open Access Journals (Sweden)
Benjamin P. Murphy
2012-05-01
Full Text Available Digital Humanities are a hot topic in disciplines as varied as literature, history and cultural studies, but at present theology and religious studies departments seem to be lagging behind. This essay will offer a critical review of one Digital Humanities project that is relevant to theological libraries and Biblical Studies: the Qumran Visualization Project. The essay will discuss why theological libraries should start considering the Digital Humanities, and then offer some strategies for how libraries can support, promote or otherwise engage with this type of project.
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Directory of Open Access Journals (Sweden)
Dardenne P.
2004-01-01
Full Text Available A key aspect of the European STRATFEED project on developing and validating analytical methods to detect animal meal in feed was the creation of a samples bank. To manage the 2,500 samples that were stored in the samples bank, another important objective was to build a database and develop an Internet-based data explorer the STRATFEED explorer to enable all laboratories and manufacturers working in the feed sector to make use of the database. The concept developed for the STRATFEED project could be used for samples management in other projects and it is easily adapted to meet a variety of requirements. The STRATFEED explorer can now be run from the public website http://stratfeed.cra.wallonie.be. Each webpage of this application is described in a documentation file aimed at helping the user to explore the database.
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Interactive Exploration Robots: Human-Robotic Collaboration and Interactions
Fong, Terry
2017-01-01
For decades, NASA has employed different operational approaches for human and robotic missions. Human spaceflight missions to the Moon and in low Earth orbit have relied upon near-continuous communication with minimal time delays. During these missions, astronauts and mission control communicate interactively to perform tasks and resolve problems in real-time. In contrast, deep-space robotic missions are designed for operations in the presence of significant communication delay - from tens of minutes to hours. Consequently, robotic missions typically employ meticulously scripted and validated command sequences that are intermittently uplinked to the robot for independent execution over long periods. Over the next few years, however, we will see increasing use of robots that blend these two operational approaches. These interactive exploration robots will be remotely operated by humans on Earth or from a spacecraft. These robots will be used to support astronauts on the International Space Station (ISS), to conduct new missions to the Moon, and potentially to enable remote exploration of planetary surfaces in real-time. In this talk, I will discuss the technical challenges associated with building and operating robots in this manner, along with lessons learned from research conducted with the ISS and in the field.
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Space Mission Human Reliability Analysis (HRA) Project
National Aeronautics and Space Administration — The purpose of this project is to extend current ground-based Human Reliability Analysis (HRA) techniques to a long-duration, space-based tool to more effectively...
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All about the Human Genome Project (HGP)
... Care Genomic Medicine Working Group New Horizons and Research Patient Management Policy and Ethics Issues Quick Links for Patient Care Education All About the Human Genome Project Fact Sheets Genetic Education Resources for ...
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Exploring the Role of Social Software in Global Software Development Projects
DEFF Research Database (Denmark)
Giuffrida, Rosalba; Dittrich, Y.
2011-01-01
We present a PhD project that investigates the use of Social Software (SoSo) in Global Software Development (GSD) teams. Since SoSo in unstructured and informal in its own nature, we explore how informal communication, which is challenging in GSD, is supported by SoSo in distributed teams and how...
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Planning the human variome project: the Spain report.
Kaput, J.; Cotton, R.G.; Hardman, L.; Watson, M.; Aqeel, A.I. Al; Al-Aama, J.Y.; Al-Mulla, F.; Alonso, S.; Aretz, S.; Auerbach, A.D.; Bapat, B.; Bernstein, I.T.; Bhak, J.; Bleoo, S.L.; Blocker, H.; Brenner, S.E.; Burn, J.; Bustamante, M.; Calzone, R.; Cambon-Thomsen, A.; Cargill, M.; Carrera, P.; Cavedon, L.; Cho, Y.S.; Chung, Y.J.; Claustres, M.; Cutting, G.; Dalgleish, R.; Dunnen, J.T. den; Diaz, C.; Dobrowolski, S.; Santos, M.R. dos; Ekong, R.; Flanagan, S.B.; Flicek, P.; Furukawa, Y.; Genuardi, M.; Ghang, H.; Golubenko, M.V.; Greenblatt, M.S.; Hamosh, A.; Hancock, J.M.; Hardison, R.; Harrison, T.M.; Hoffmann, R.; Horaitis, R.; Howard, H.J.; Barash, C.I.; Izagirre, N.; Jung, J.; Kojima, T.; Laradi, S.; Lee, Y.S.; Lee, J.Y.; Gil-da-Silva-Lopes, V.L.; Macrae, F.A.; Maglott, D.; Marafie, M.J.; Marsh, S.G.; Matsubara, Y.; Messiaen, L.M.; Moslein, G.; Netea, M.G.; Norton, M.L.; Oefner, P.J.; Oetting, W.S.; O'Leary, J.C.; Ramirez, A.M. de; Paalman, M.H.; Parboosingh, J.; Patrinos, G.P.; Perozzi, G.; Phillips, I.R.; Povey, S.; Prasad, S.; Qi, M.; Quin, D.J.; Ramesar, R.S.; Richards, C.S.; Savige, J.; Scheible, D.G.; Scott, R.J.; Seminara, D.; Shephard, E.A.; Sijmons, R.H.; Smith, T.D.; Sobrido, M.J.; Tanaka, T.; Tavtigian, S.V.; Taylor, G.R.; Teague, J.; Topel, T.; Ullman-Cullere, M.; Utsunomiya, J.; Kranen, H.J. van; Vihinen, M.; Webb, E.; Weber, T.K.; Yeager, M.
2009-01-01
The remarkable progress in characterizing the human genome sequence, exemplified by the Human Genome Project and the HapMap Consortium, has led to the perception that knowledge and the tools (e.g., microarrays) are sufficient for many if not most biomedical research efforts. A large amount of data
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Planning the Human Variome Project : The Spain Report
Kaput, Jim; Cotton, Richard G. H.; Hardman, Lauren; Watson, Michael; Al Aqeel, Aida I.; Al-Aama, Jumana Y.; Al-Mulla, Fahd; Alonso, Santos; Aretz, Stefan; Auerbach, Arleen D.; Bapat, Bharati; Bernstein, Inge T.; Bhak, Jong; Bleoo, Stacey L.; Bloecker, Helmut; Brenner, Steven E.; Burn, John; Bustamante, Mariona; Calone, Rita; Cambon-Thomsen, Anne; Cargill, Michele; Carrera, Paola; Cavedon, Lawrence; Cho, Yoon Shin; Chung, Yeun-Jun; Claustres, Mireille; Cutting, Garry; Dalgleish, Raymond; den Dunnen, Johan T.; Diaz, Carlos; Dobrowolski, Steven; dos Santos, M. Rosario N.; Ekong, Rosemary; Flanagan, Simon B.; Flicek, Paul; Furukawa, Yoichi; Genuardi, Maurizio; Ghang, Ho; Golubenko, Maria V.; Greenblatt, Marc S.; Hamosh, Ada; Hancock, John M.; Hardison, Ross; Harrison, Terence M.; Hoffmann, Robert; Horaitis, Rania; Howard, Heather J.; Barash, Carol Isaacson; Izagirre, Neskuts; Sijmons, Rolf H.
The remarkable progress in characterizing the human genome sequence, exemplified by the Human Genome Project and the HapMap Consortium, has led to the perception that knowledge and the tools (e.g., microarrays) are sufficient for many if not most biomedical research efforts. A large amount of data
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Planning the human variome project: the Spain report
DEFF Research Database (Denmark)
Kaput, Jim; Cotton, Richard G H; Hardman, Lauren
2009-01-01
The remarkable progress in characterizing the human genome sequence, exemplified by the Human Genome Project and the HapMap Consortium, has led to the perception that knowledge and the tools (e.g., microarrays) are sufficient for many if not most biomedical research efforts. A large amount of dat...
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Energy Technology Data Exchange (ETDEWEB)
NONE
1999-06-01
Zeta Phi Beta Sorority National Educational Foundation, in cooperation with Xavier University of New Orleans, and the New Orleans District Office of the United States Equal Employment Opportunity Commission, held the Information and Dialogue Conference on the Human Genome Project for the Minority Communities in the State of Louisiana on April 16-17, 1999. The Conference was held on the campus of Xavier University in New Orleans. Community leaders, government officials, minority professional and social organizations leaders, religious leaders, persons from the educational and academic community, and students were invited. Conference objectives included bringing HGP information and a focus in the minority community on the project, in clear and understandable terms, to spread the work in the minority community about the project; to explore the likely positive implications with respect to health care and related matters; to explore possible negative results and strategies to meet them; to discuss the social, legal, and ethical implications; and to facilitate minority input into the HGP as it develops.
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Solar Electric Propulsion Concepts for Human Space Exploration
Mercer, Carolyn R.; Mcguire, Melissa L.; Oleson, Steven R.; Barrett, Michael J.
2016-01-01
Advances in solar array and electric thruster technologies now offer the promise of new, very capable space transportation systems that will allow us to cost effectively explore the solar system. NASA has developed numerous solar electric propulsion spacecraft concepts with power levels ranging from tens to hundreds of kilowatts for robotic and piloted missions to asteroids and Mars. This paper describes nine electric and hybrid solar electric/chemical propulsion concepts developed over the last 5 years and discusses how they might be used for human exploration of the inner solar system.
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Origins of the Human Genome Project
Cook-Deegan, Robert (Affiliation: Institute of Medicine, National Academy of Sciences)
1993-07-01
The human genome project was borne of technology, grew into a science bureaucracy in the United States and throughout the world, and is now being transformed into a hybrid academic and commercial enterprise. The next phase of the project promises to veer more sharply toward commercial application, harnessing both the technical prowess of molecular biology and the rapidly growing body of knowledge about DNA structure to the pursuit of practical benefits. Faith that the systematic analysis of DNA structure will prove to be a powerful research tool underlies the rationale behind the genome project. The notion that most genetic information is embedded in the sequence of CNA base pairs comprising chromosomes is a central tenet. A rough analogy is to liken an organism's genetic code to computer code. The coal of the genome project, in this parlance, is to identify and catalog 75,000 or more files (genes) in the software that directs construction of a self-modifying and self-replicating system -- a living organism.
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Origins of the Human Genome Project
Energy Technology Data Exchange (ETDEWEB)
Cook-Deegan, Robert
1993-07-01
The human genome project was borne of technology, grew into a science bureaucracy in the US and throughout the world, and is now being transformed into a hybrid academic and commercial enterprise. The next phase of the project promises to veer more sharply toward commercial application, harnessing both the technical prowess of molecular biology and the rapidly growing body of knowledge about DNA structure to the pursuit of practical benefits. Faith that the systematic analysis of DNA structure will prove to be a powerful research tool underlies the rationale behind the genome project. The notion that most genetic information is embedded in the sequence of CNA base pairs comprising chromosomes is a central tenet. A rough analogy is to liken an organism's genetic code to computer code. The coal of the genome project, in this parlance, is to identify and catalog 75,000 or more files (genes) in the software that directs construction of a self-modifying and self-replicating system -- a living organism.
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The Human Genome Project: An Imperative for International Collaboration.
Allende, J. E.
1989-01-01
Discussed is the Human Genome Project which aims to decipher the totality of the human genetic information. The historical background, the objectives, international cooperation, ethical discussion, and the role of UNESCO are included. (KR)
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Human genome project: revolutionizing biology through leveraging technology
Dahl, Carol A.; Strausberg, Robert L.
1996-04-01
The Human Genome Project (HGP) is an international project to develop genetic, physical, and sequence-based maps of the human genome. Since the inception of the HGP it has been clear that substantially improved technology would be required to meet the scientific goals, particularly in order to acquire the complete sequence of the human genome, and that these technologies coupled with the information forthcoming from the project would have a dramatic effect on the way biomedical research is performed in the future. In this paper, we discuss the state-of-the-art for genomic DNA sequencing, technological challenges that remain, and the potential technological paths that could yield substantially improved genomic sequencing technology. The impact of the technology developed from the HGP is broad-reaching and a discussion of other research and medical applications that are leveraging HGP-derived DNA analysis technologies is included. The multidisciplinary approach to the development of new technologies that has been successful for the HGP provides a paradigm for facilitating new genomic approaches toward understanding the biological role of functional elements and systems within the cell, including those encoded within genomic DNA and their molecular products.
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Oxytocin modulates human communication by enhancing cognitive exploration.
de Boer, Miriam; Kokal, Idil; Blokpoel, Mark; Liu, Rui; Stolk, Arjen; Roelofs, Karin; van Rooij, Iris; Toni, Ivan
2017-12-01
Oxytocin is a neuropeptide known to influence how humans share material resources. Here we explore whether oxytocin influences how we share knowledge. We focus on two distinguishing features of human communication, namely the ability to select communicative signals that disambiguate the many-to-many mappings that exist between a signal's form and meaning, and adjustments of those signals to the presumed cognitive characteristics of the addressee ("audience design"). Fifty-five males participated in a randomized, double-blind, placebo controlled experiment involving the intranasal administration of oxytocin. The participants produced novel non-verbal communicative signals towards two different addressees, an adult or a child, in an experimentally-controlled live interactive setting. We found that oxytocin administration drives participants to generate signals of higher referential quality, i.e. signals that disambiguate more communicative problems; and to rapidly adjust those communicative signals to what the addressee understands. The combined effects of oxytocin on referential quality and audience design fit with the notion that oxytocin administration leads participants to explore more pervasively behaviors that can convey their intention, and diverse models of the addressees. These findings suggest that, besides affecting prosocial drive and salience of social cues, oxytocin influences how we share knowledge by promoting cognitive exploration. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Daedalus Project's Light Eagle - Human powered aircraft
1987-01-01
The Michelob Light Eagle is seen here in flight over Rogers Dry Lake at the NASA Dryden Flight Research Center, Edwards, California. The Light Eagle and Daedalus human powered aircraft were testbeds for flight research conducted at Dryden between January 1987 and March 1988. These unique aircraft were designed and constructed by a group of students, professors, and alumni of the Massachusetts Institute of Technology within the context of the Daedalus project. The construction of the Light Eagle and Daedalus aircraft was funded primarily by the Anheuser Busch and United Technologies Corporations, respectively, with additional support from the Smithsonian Air and Space Museum, MIT, and a number of other sponsors. To celebrate the Greek myth of Daedalus, the man who constructed wings of wax and feathers to escape King Minos, the Daedalus project began with the goal of designing, building and testing a human-powered aircraft that could fly the mythical distance, 115 km. To achieve this goal, three aircraft were constructed. The Light Eagle was the prototype aircraft, weighing 92 pounds. On January 22, 1987, it set a closed course distance record of 59 km, which still stands. Also in January of 1987, the Light Eagle was powered by Lois McCallin to set the straight distance, the distance around a closed circuit, and the duration world records for the female division in human powered vehicles. Following this success, two more aircraft were built, the Daedalus 87 and Daedalus 88. Each aircraft weighed approximately 69 pounds. The Daedalus 88 aircraft was the ship that flew the 199 km from the Iraklion Air Force Base on Crete in the Mediterranean Sea, to the island of Santorini in 3 hours, 54 minutes. In the process, the aircraft set new records in distance and endurance for a human powered aircraft. The specific areas of flight research conducted at Dryden included characterizing the rigid body and flexible dynamics of the Light Eagle, investigating sensors for an
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An overview of the human genome project
Energy Technology Data Exchange (ETDEWEB)
Batzer, M.A.
1994-01-01
The human genome project is one of the most ambitious scientific projects to date, with the ultimate goal being a nucleotide sequence for all four billion bases of human DNA. In the process of determining the nucleotide sequence for each base, the location, function, and regulatory regions from the estimated 100,000 human genes will be identified. The genome project itself relies upon maps of the human genetic code derived from several different levels of resolution. Genetic linkage analysis provides a low resolution genome map. The information for genetic linkage maps is derived from the analysis of chromosome specific markers such as Sequence Tagged Sites (STSs), Variable Number of Tandem Repeats (VNTRs) or other polymorphic (highly informative) loci in a number of different-families. Using this information the location of an unknown disease gene can be limited to a region comprised of one million base pairs of DNA or less. After this point, one must construct or have access to a physical map of the region of interest. Physical mapping involves the construction of an ordered overlapping (contiguous) set of recombinant DNA clones. These clones may be derived from a number of different vectors including cosmids, Bacterial Artificial Chromosomes (BACs), P1 derived Artificial Chromosomes (PACs), somatic cell hybrids, or Yeast Artificial Chromosomes (YACs). The ultimate goal for physical mapping is to establish a completely overlapping (contiguous) set of clones for the entire genome. After a gene or region of interest has been localized using physical mapping the nucleotide sequence is determined. The overlap between genetic mapping, physical mapping and DNA sequencing has proven to be a powerful tool for the isolation of disease genes through positional cloning.
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Human factors and technology environment in multinational project: problems and solutions
International Nuclear Information System (INIS)
Jardi Besa, X.; Munoz Cervantes, A.
2012-01-01
At the onset of nuclear projects in Spain, there was an import of nuclear technology. In a second phase, there was a transfer of technology. Subsequently, there was an adaptation of the technology. In this evolution, comparable to that of other countries, were involved several countries, overcoming the difficulties of human factors involved. The current nuclear projects multinationals have a new difficulty: the different industrial technological environments. This paper will address the organizational challenges of multinational engineering projects, in the type of project and the human factors of the participating companies.
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Harrington, A. D.; McCubbin, F. M.; Vander Kaaden, K. E.; Kaur, J.; Smirnov, A.; Galdanes, K.; Schoonen, M. A. A.; Chen, L. C.; Tsirka, S. E.; Gordon, T.
2018-01-01
New initiatives to send humans to Mars within the next few decades are illustrative of the resurgence of interest in space travel. However, as with all exploration, there are risks. The Human Research Roadmap developed by NASA identifies the Risk of Adverse Health and Performance Effects of Celestial Dust Exposure as an area of concern. Extended human exploration will further increase the probability of inadvertent and repeated exposures to celestial dusts.
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Space Exploration as a Human Enterprise: The Scientific Interest
Sagan, Carl
1973-01-01
Presents examples which illustrate the importance of space exploration in diverse aspects of scientific knowledge. Indicates that human beings are today not wise enough to anticipate the practical benefits of planetary studies. (CC)
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Human Health and Performance Considerations for Exploration of Near-Earth Asteroids
Kundrot, Craig; Steinberg, Susan; Charles, John
2010-01-01
This presentation will describe the human health and performance issues that are anticipated for the human exploration of near-Earth asteroids (NEA). Humans are considered a system in the design of any such deep-space exploration mission, and exploration of NEA presents unique challenges for the human system. Key factors that define the mission are those that are strongly affected by distance and duration. The most critical of these is deep-space radiation exposure without even the temporary shielding of a nearby large planetary body. The current space radiation permissible exposure limits (PEL) restrict mission duration to 3-10 months depending on age and gender of crewmembers and stage of the solar cycle. Factors that affect mission architecture include medical capability; countermeasures for bone, muscle, and cardiovascular atrophy during continuous weightlessness; restricted food supplies; and limited habitable volume. The design of a habitat that can maintain the physical and psychological health of the crew and support mission operations with limited intervention from Earth will require an integrated research and development effort by NASA s Human Research Program, engineering, and human factors groups. Limited abort and return options for an NEA mission are anticipated to have important effects on crew psychology as well as influence medical supplies and training requirements of the crew. Other important factors are those related to isolation, confinement, communication delays, autonomous operations, task design, small crew size, and even the unchanging view outside the windows for most of the mission. Geological properties of the NEA will influence design of sample handling and containment, and extravehicular activity capabilities including suit ports and tools. A robotic precursor mission that collects basic information on NEA surface properties would reduce uncertainty about these aspects of the mission as well as aid in design of mission architecture and
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The Ethanol Project: Exploring Alternative Energy with Role-Play and Writing
Winter, Julia
2013-01-01
This article describes a project that includes a two-week series of researching, essay writing, and speaking lessons exploring the broader implications of using ethanol as a fuel. The author, a chemistry teacher, describes how she uses a senate hearing discussion of ethanol fuel subsidies as the forum for a role-play. The four components of the…
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Directory of Open Access Journals (Sweden)
S. A. Starovoitova
2013-06-01
Full Text Available Modern huge and world-wide known projects concerning studying of human microbial ecology and construction of probiotics, particularly: Society for Microbial Ecology and Disease, Probiotics & Health Targeted Initiative of International Science and Technology Center (TI PROBIO ISTC, Human Microbiome Project of National Institutes of Health, MetaHIT Project (Metagenomics of the Human Intestinal Tract of European Commission, Human Metabolome Project of Canadian University of Alberta and some more else were characterized in the article. Brief historical information and reference to official sites of every discussed project were given. Main goals and tasks of every project were described. Short characteristic of discussed projects and also modern accessible results of researches were given. Importance of every examined project for widening scientific knowledge in the field of human microbial ecology and also for improvement and/or for construction of modern effective probiotics on basis of human normal intestinal microflora were paid attention. Close interaction of scientific data received by realization of every discussed project was shown.
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Frontiers of Life Sciences: The Human Exploration of the Moon and Mars
North, Regina M.; Pellis, Neal R.
2005-01-01
The rapid development of the productive processes after World War II extended human settlements into new ecological niches. Advances in Life Sciences played a decisive role supporting the establishment of human presence in areas of the planet where human life could have not existed otherwise. The evolution of life support systems, and the fabrication of new materials and technologies has enabled humans to inhabit Polar Regions, ocean surfaces and depths; and to leave Earth and occupy Low Earth Orbit. By the end of the 20 th Century, stations in the Antarctic and Arctic, off shore oil platforms, submarines, and space stations had become the ultimate demonstration of human ability to engineer habitats at Earth extreme environments and outer space. As we enter the 21st Century, the next development of human settlements will occur through the exploration of the Moon, Mars, and beyond. The major risks of space exploration derive from long exposure of humans and other life systems to radiation, microgravity, isolation and confinement, dependence on artificial life support systems, and unknown effects (e.g., altered magnetic fields, ultrahigh vacuum on bacteria, fungi, etc.). Countermeasures will require a complete characterization of human and other biological systems adaptation processes. To sustain life in transit and on the surface of the Moon and Mars will require a balance of spacecraft, cargo, astronaut crews, and the use of in situ resources. Limitations on the number of crewmembers, payloads, and the barrenness of the terrain require a novel design for the capabilities needed in transit and at exploration outpost sites. The planned destinations have resources that may be accessed to produce materials, food, shelter, power, and to provide an environment compatible with successful occupation of longterm exploration sites. Once more, the advancements of Life Sciences will be essential for the design of interplanetary voyages and planetary surface operations. This
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Gangadharan, Gireesh; Shin, Jonghan; Kim, Seong-Wook; Kim, Angela; Paydar, Afshin; Kim, Duk-Soo; Miyazaki, Taisuke; Watanabe, Masahiko; Yanagawa, Yuchio; Kim, Jinhyun; Kim, Yeon-Soo; Kim, Daesoo; Shin, Hee-Sup
2016-01-01
Exploratory drive is one of the most fundamental emotions, of all organisms, that are evoked by novelty stimulation. Exploratory behavior plays a fundamental role in motivation, learning, and well-being of organisms. Diverse exploratory behaviors have been described, although their heterogeneity is not certain because of the lack of solid experimental evidence for their distinction. Here we present results demonstrating that different neural mechanisms underlie different exploratory behaviors. Localized Cav3.1 knockdown in the medial septum (MS) selectively enhanced object exploration, whereas the null mutant (KO) mice showed enhanced-object exploration as well as open-field exploration. In MS knockdown mice, only type 2 hippocampal theta rhythm was enhanced, whereas both type 1 and type 2 theta rhythm were enhanced in KO mice. This selective effect was accompanied by markedly increased excitability of septo-hippocampal GABAergic projection neurons in the MS lacking T-type Ca2+ channels. Furthermore, optogenetic activation of the septo-hippocampal GABAergic pathway in WT mice also selectively enhanced object exploration behavior and type 2 theta rhythm, whereas inhibition of the same pathway decreased the behavior and the rhythm. These findings define object exploration distinguished from open-field exploration and reveal a critical role of T-type Ca2+ channels in the medial septal GABAergic projection neurons in this behavior. PMID:27208094
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The effect of atomoxetine on random and directed exploration in humans.
Warren, Christopher M; Wilson, Robert C; van der Wee, Nic J; Giltay, Eric J; van Noorden, Martijn S; Cohen, Jonathan D; Nieuwenhuis, Sander
2017-01-01
The adaptive regulation of the trade-off between pursuing a known reward (exploitation) and sampling lesser-known options in search of something better (exploration) is critical for optimal performance. Theory and recent empirical work suggest that humans use at least two strategies for solving this dilemma: a directed strategy in which choices are explicitly biased toward information seeking, and a random strategy in which decision noise leads to exploration by chance. Here we examined the hypothesis that random exploration is governed by the neuromodulatory locus coeruleus-norepinephrine system. We administered atomoxetine, a norepinephrine transporter blocker that increases extracellular levels of norepinephrine throughout the cortex, to 22 healthy human participants in a double-blind crossover design. We examined the effect of treatment on performance in a gambling task designed to produce distinct measures of directed exploration and random exploration. In line with our hypothesis we found an effect of atomoxetine on random, but not directed exploration. However, contrary to expectation, atomoxetine reduced rather than increased random exploration. We offer three potential explanations of our findings, involving the non-linear relationship between tonic NE and cognitive performance, the interaction of atomoxetine with other neuromodulators, and the possibility that atomoxetine affected phasic norepinephrine activity more so than tonic norepinephrine activity.
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Directory of Open Access Journals (Sweden)
Voronin D. M.
2016-03-01
Full Text Available As part of the research, the content of the required theoretical and methodological tools in the field of corporate finance investment projects of exploration and production of hydrocarbons described. Indicated cash flow characteristics of such projects in accordance with the phases of the project, identified the risks associated with cash flows. In practical terms, the proposed approach to the financing of projects includes sequential algorithm deciding on the implementation of funding is considered on case studies and can be used in the process of financial planning oil and gas companies, in building policy project financing, corporate procedures and regulations. In solving problems of theoretical and applied scientific methods used in the study, including methods of logical, comparative and systematic analysis, as well as methods of economic-mathematical modeling.
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DEFF Research Database (Denmark)
Tryggestad, Kjell; Justesen, Lise; Mouritsen, Jan
2013-01-01
Purpose – The purpose of this paper is to explore how animals can become stakeholders in interaction with project management technologies and what happens with project temporalities when new and surprising stakeholders become part of a project and a recognized matter of concern to be taken...... into account. Design/methodology/approach – The paper is based on a qualitative case study of a project in the building industry. The authors use actor-network theory (ANT) to analyze the emergence of animal stakeholders, stakes and temporalities. Findings – The study shows how project temporalities can...... multiply in interaction with project management technologies and how conventional linear conceptions of project time may be contested with the emergence of new non-human stakeholders and temporalities. Research limitations/implications – The study draws on ANT to show how animals can become stakeholders...
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High-Rate Laser Communications for Human Exploration and Science
Robinson, B. S.; Shih, T.; Khatri, F. I.; King, T.; Seas, A.
2018-02-01
Laser communication links has been successfully demonstrated on recent near-Earth and lunar missions. We present a status of this development work and its relevance to a future Deep Space Gateway supporting human exploration and science activities.
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Planning the human variome project: the Spain report.
Kaput, Jim; Cotton, Richard G H; Hardman, Lauren; Watson, Michael; Al Aqeel, Aida I; Al-Aama, Jumana Y; Al-Mulla, Fahd; Alonso, Santos; Aretz, Stefan; Auerbach, Arleen D; Bapat, Bharati; Bernstein, Inge T; Bhak, Jong; Bleoo, Stacey L; Blöcker, Helmut
2009-01-01
The remarkable progress in characterizing the human genome sequence, exemplified by the Human Genome Project and the HapMap Consortium, has led to the perception that knowledge and the tools (e.g., microarrays) are sufficient for many if not most biomedical research efforts. A large amount of data from diverse studies proves this perception inaccurate at best, and at worst, an impediment for further efforts to characterize the variation in the human genome. Because variation in genotype and e...
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Crew systems: integrating human and technical subsystems for the exploration of space
Connors, M. M.; Harrison, A. A.; Summit, J.
1994-01-01
Space exploration missions will require combining human and technical subsystems into overall "crew systems" capable of performing under the rigorous conditions of outer space. This report describes substantive and conceptual relationships among humans, intelligent machines, and communication systems, and explores how these components may be combined to complement and strengthen one another. We identify key research issues in the combination of humans and technology and examine the role of individual differences, group processes, and environmental conditions. We conclude that a crew system is, in effect, a social cyborg, a living system consisting of multiple individuals whose capabilities are extended by advanced technology.
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Kachaluba, Sarah Buck; Brady, Jessica Evans; Critten, Jessica
2014-01-01
This article is based on quantitative and qualitative research examining humanities scholars' understandings of the advantages and disadvantages of print versus electronic information resources. It explores how humanities' faculty members at Florida State University (FSU) use print and electronic resources, as well as how they perceive these…
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The Human Genome Project: big science transforms biology and medicine
Hood, Leroy; Rowen, Lee
2013-01-01
The Human Genome Project has transformed biology through its integrated big science approach to deciphering a reference human genome sequence along with the complete sequences of key model organisms. The project exemplifies the power, necessity and success of large, integrated, cross-disciplinary efforts - so-called ‘big science’ - directed towards complex major objectives. In this article, we discuss the ways in which this ambitious endeavor led to the development of novel technologies and a...
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Space Resource Utilization: Near-Term Missions and Long-Term Plans for Human Exploration
Sanders, Gerald B.
2015-01-01
A primary goal of all major space faring nations is to explore space: from the Earth with telescopes, with robotic probes and space telescopes, and with humans. For the US National Aeronautics and Space Administration (NASA), this pursuit is captured in three important strategic goals: 1. Ascertain the content, origin, and evolution of the solar system and the potential for life elsewhere, 2. Extend and sustain human activities across the solar system (especially the surface of Mars), and 3. Create innovative new space technologies for exploration, science, and economic future. While specific missions and destinations are still being discussed as to what comes first, it is imperative for NASA that it foster the development and implementation of new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable human exploration beyond low Earth orbit (LEO) is the development of technologies and systems to identify, extract, and use resources in space instead of bringing everything from Earth. To reduce the development and implementation costs for space resource utilization, often called In Situ Resource Utilization (ISRU), it is imperative to work with terrestrial mining companies to spin-in/spin-off technologies and capabilities, and space mining companies to expand our economy beyond Earth orbit. In the last two years, NASA has focused on developing and implementing a sustainable human space exploration program with the ultimate goal of exploring the surface of Mars with humans. The plan involves developing technology and capability building blocks critical for sustained exploration starting with the Space Launch System (SLS) and Orion crew spacecraft and utilizing the International Space Station as a springboard into the solar system. The evolvable plan develops and expands human exploration in phases starting with missions that are reliant on Earth, to performing ever more challenging and
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Exploration Laboratory Analysis
Krihak, M.; Ronzano, K.; Shaw, T.
2016-01-01
The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability (ExMC) risk to minimize or reduce the risk of adverse health outcomes and decrements in performance due to in-flight medical capabilities on human exploration missions. To mitigate this risk, the availability of inflight laboratory analysis instrumentation has been identified as an essential capability for manned exploration missions. Since a single, compact space-ready laboratory analysis capability to perform all exploration clinical measurements is not commercially available, the ELA project objective is to demonstrate the feasibility of emerging operational and analytical capability as a biomedical diagnostics precursor to long duration manned exploration missions. The initial step towards ground and flight demonstrations in fiscal year (FY) 2015 was the down selection of platform technologies for demonstrations in the space environment. The technologies selected included two Small Business Innovation Research (SBIR) performers: DNA Medicine Institutes rHEALTH X and Intelligent Optical Systems later flow assays combined with Holomics smartphone analyzer. The selection of these technologies were based on their compact size, breadth of analytical capability and favorable ability to process fluids in a space environment, among several factors. These two technologies will be advanced to meet ground and flight demonstration success criteria and requirements that will be finalized in FY16. Also, the down selected performers will continue the technology development phase towards meeting prototype deliverables in either late 2016 or 2017.
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MotionExplorer: exploratory search in human motion capture data based on hierarchical aggregation.
Bernard, Jürgen; Wilhelm, Nils; Krüger, Björn; May, Thorsten; Schreck, Tobias; Kohlhammer, Jörn
2013-12-01
We present MotionExplorer, an exploratory search and analysis system for sequences of human motion in large motion capture data collections. This special type of multivariate time series data is relevant in many research fields including medicine, sports and animation. Key tasks in working with motion data include analysis of motion states and transitions, and synthesis of motion vectors by interpolation and combination. In the practice of research and application of human motion data, challenges exist in providing visual summaries and drill-down functionality for handling large motion data collections. We find that this domain can benefit from appropriate visual retrieval and analysis support to handle these tasks in presence of large motion data. To address this need, we developed MotionExplorer together with domain experts as an exploratory search system based on interactive aggregation and visualization of motion states as a basis for data navigation, exploration, and search. Based on an overview-first type visualization, users are able to search for interesting sub-sequences of motion based on a query-by-example metaphor, and explore search results by details on demand. We developed MotionExplorer in close collaboration with the targeted users who are researchers working on human motion synthesis and analysis, including a summative field study. Additionally, we conducted a laboratory design study to substantially improve MotionExplorer towards an intuitive, usable and robust design. MotionExplorer enables the search in human motion capture data with only a few mouse clicks. The researchers unanimously confirm that the system can efficiently support their work.
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Exploring Protein Structure and Dynamics through a Project-Oriented Biochemistry Laboratory Module
Lipchock, James M.; Ginther, Patrick S.; Douglas, Bonnie B.; Bird, Kelly E.; Loria, J. Patrick
2017-01-01
Here, we present a 10-week project-oriented laboratory module designed to provide a course-based undergraduate research experience in biochemistry that emphasizes the importance of biomolecular structure and dynamics in enzyme function. This module explores the impact of mutagenesis on an important active site loop for a biomedically-relevant…
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Compilation Of An Econometric Human Resource Efficiency Model For Project Management Best Practices
G. van Zyl; P. Venier
2006-01-01
The aim of the paper is to introduce a human resource efficiency model in order to rank the most important human resource driving forces for project management best practices. The results of the model will demonstrate how the human resource component of project management acts as the primary function to enhance organizational performance, codified through improved logical end-state programmes, work ethics and process contributions. Given the hypothesis that project management best practices i...
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Development of human factors engineering guide for nuclear power project
International Nuclear Information System (INIS)
Wu Dangshi; Sheng Jufang
1997-01-01
'THE PRACTICAL GUIDE FOR APPLICATION OF HUMAN FACTORS ENGINEERING TO NUCLEAR POWER PROJECT (First Draft, in Chinese)', which was developed under a research program sponsored by National Nuclear Safety Administration (NNSA) is described briefly. It is hoped that more conscious, more systematical and more comprehensive application of Human Factors Engineering to the nuclear power projects from the preliminary feasibility studies up to the commercial operation will benefit the safe, efficient and economical operations of nuclear power plants in China
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Marquez, Jessica J.
2016-01-01
Future exploration missions will require NASA to integrate more automation and robotics in order to accomplish mission objectives. This presentation will describe on the future challenges facing the human operator (astronaut, ground controllers) as we increase the amount of automation and robotics in spaceflight operations. It will describe how future exploration missions will have to adapt and evolve in order to deal with more complex missions and communication latencies. This presentation will outline future human-automation-robotic integration challenges.
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NASA Laboratory Analysis for Manned Exploration Missions
Krihak, Michael K.; Shaw, Tianna E.
2014-01-01
The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability Element under the NASA Human Research Program. ELA instrumentation is identified as an essential capability for future exploration missions to diagnose and treat evidence-based medical conditions. However, mission architecture limits the medical equipment, consumables, and procedures that will be available to treat medical conditions during human exploration missions. Allocated resources such as mass, power, volume, and crew time must be used efficiently to optimize the delivery of in-flight medical care. Although commercial instruments can provide the blood and urine based measurements required for exploration missions, these commercial-off-the-shelf devices are prohibitive for deployment in the space environment. The objective of the ELA project is to close the technology gap of current minimally invasive laboratory capabilities and analytical measurements in a manner that the mission architecture constraints impose on exploration missions. Besides micro gravity and radiation tolerances, other principal issues that generally fail to meet NASA requirements include excessive mass, volume, power and consumables, and nominal reagent shelf-life. Though manned exploration missions will not occur for nearly a decade, NASA has already taken strides towards meeting the development of ELA medical diagnostics by developing mission requirements and concepts of operations that are coupled with strategic investments and partnerships towards meeting these challenges. This paper focuses on the remote environment, its challenges, biomedical diagnostics requirements and candidate technologies that may lead to successful blood-urine chemistry and biomolecular measurements in future space exploration missions.
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Compilation Of An Econometric Human Resource Efficiency Model For Project Management Best Practices
Directory of Open Access Journals (Sweden)
G. van Zyl
2006-11-01
Full Text Available The aim of the paper is to introduce a human resource efficiency model in order to rank the most important human resource driving forces for project management best practices. The results of the model will demonstrate how the human resource component of project management acts as the primary function to enhance organizational performance, codified through improved logical end-state programmes, work ethics and process contributions. Given the hypothesis that project management best practices involve significant human resource and organizational changes, one would reasonably expect this process to influence and resonate throughout all the dimensions of an organisation.
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Reid, Concha M.; Miller, Thomas B.; Mercer, Carolyn R.; Jankovsky, Amy L.
2010-01-01
Technical Interchange Meeting was held at Saft America s Research and Development facility in Cockeysville, Maryland on Sept 28th-29th, 2010. The meeting was attended by Saft, contractors who are developing battery component materials under contracts awarded through a NASA Research Announcement (NRA), and NASA. This briefing presents an overview of the components being developed by the contractor attendees for the NASA s High Energy (HE) and Ultra High Energy (UHE) cells. The transition of the advanced lithium-ion cell development project at NASA from the Exploration Technology Development Program Energy Storage Project to the Enabling Technology Development and Demonstration High Efficiency Space Power Systems Project, changes to deliverable hardware and schedule due to a reduced budget, and our roadmap to develop cells and provide periodic off-ramps for cell technology for demonstrations are discussed. This meeting gave the materials and cell developers the opportunity to discuss the intricacies of their materials and determine strategies to address any particulars of the technology.
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Directory of Open Access Journals (Sweden)
Jesús Estepa Giménez
2012-04-01
Full Text Available In this paper the authors present how they research and innovate in Initial Teacher Education programmes throught the `Exploring our world´ project (6-12. Along the article aspects related to the why, what for and how to teach of the curricular project are analysed by means of the example of `Exploring current and historical societies´. Trainees´ productions on this Field of Research are presented, in which they deal with the three afore-mentioned elements throught the design of didactic units that form part, like a portfolio, of the group reseach file.
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The Human Genome Project and Biology Education.
McInerney, Joseph D.
1996-01-01
Highlights the importance of the Human Genome Project in educating the public about genetics. Discusses four challenges that science educators must address: teaching for conceptual understanding, the nature of science, the personal and social impact of science and technology, and the principles of technology. Contains 45 references. (JRH)
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ESA strategy for human exploration and the Lunar Lander Mission
Gardini, B.
As part of ESAs Aurora Exploration programme, the Agency has defined, since 2001, a road map for exploration in which, alongside robotic exploration missions, the International Space Station (ISS) and the Moon play an essential role on the way to other destinations in the Solar System, ultimately to a human mission to Mars in a more distant future. In the frame of the Human Spaceflight programme the first European Lunar Lander Mission, with a launch date on 2018, has been defined, targeting the lunar South Pole region to capitalize on unique illumination conditions and provide the opportunity to carry out scientific investigations in a region of the Moon not explored so far. The Phase B1 industrial study, recently initiated, will consolidate the mission design and prepare the ground for the approval of the full mission development phase at the 2012 ESA Council at Ministerial. This paper describes the mission options which have been investigated in the past Phase A studies and presents the main activities foreseen in the Phase B1 to consolidate the mission design, including a robust bread-boards and technology development programme. In addition, the approach to overcoming the mission's major technical and environmental challenges and the activities to advance the definition of the payload elements will be described.
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Human Capital Investment and the Completion of Risky R&D Projects
DEFF Research Database (Denmark)
Siyahhan, Baran; Engelbert, Dockner
2010-01-01
but can be observed during the R&D phase of the project. The exogenous value of the patent determines the firm’s decisions to invest in human capital, to abandon the project if nec- essary, and to invest in marketing the new product. We study the corresponding optimal stopping times, determine their value...... and risk consequences, and derive optimal investment in the stock of human capital. While optimal investment in human capital is very sensitive to its productivity do increase the probability of a breakthrough it is insensitive to changes in the volatility of the present value of the patent. The value...... of the firm is driven by fixed labor costs that occur until the breakthrough is made, the call option to invest in human capital and market the product, and the put option to abandon the project. These options together with labor costs’ based operating leverage determine the risk dynamics. Risk varies non...
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Human Capital Investment and the Value of Risky R&D Projects
DEFF Research Database (Denmark)
Dockner, Engelbert; Siyahhan, Baran
be observed during the R&D phase of the project. The exogenous value of the patent determines the firm’s decisions to invest in human capital, to abandon the project if necessary, and to invest in marketing the new product. We study the corresponding optimal stopping times, determine their value and risk...... consequences, and derive optimal investment in the stock of human capital. While optimal investment in human capital is very sensitive to its productivity do increase the probability of a breakthrough it is insensitive to changes in the volatility of the present value of the patent. The value of the firm...... is driven by fixed labor costs that occur until the breakthrough is made, the call option to invest in human capital and market the product, and the put option to abandon the project. These options together with labor costs’ based operating leverage determine the risk dynamics. Firm risk is inverse U...
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Stephens, Martin L.; Barrow, Craig; Andersen, Melvin E.; Boekelheide, Kim; Carmichael, Paul L.; Holsapple, Michael P.; Lafranconi, Mark
2012-01-01
The U.S. National Research Council (NRC) report on “Toxicity Testing in the 21st century” calls for a fundamental shift in the way that chemicals are tested for human health effects and evaluated in risk assessments. The new approach would move toward in vitro methods, typically using human cells in a high-throughput context. The in vitro methods would be designed to detect significant perturbations to “toxicity pathways,” i.e., key biological pathways that, when sufficiently perturbed, lead to adverse health outcomes. To explore progress on the report’s implementation, the Human Toxicology Project Consortium hosted a workshop on 9–10 November 2010 in Washington, DC. The Consortium is a coalition of several corporations, a research institute, and a non-governmental organization dedicated to accelerating the implementation of 21st-century Toxicology as aligned with the NRC vision. The goal of the workshop was to identify practical and scientific ways to accelerate implementation of the NRC vision. The workshop format consisted of plenary presentations, breakout group discussions, and concluding commentaries. The program faculty was drawn from industry, academia, government, and public interest organizations. Most presentations summarized ongoing efforts to modernize toxicology testing and approaches, each with some overlap with the NRC vision. In light of these efforts, the workshop identified recommendations for accelerating implementation of the NRC vision, including greater strategic coordination and planning across projects (facilitated by a steering group), the development of projects that test the proof of concept for implementation of the NRC vision, and greater outreach and communication across stakeholder communities. PMID:21948868
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The human Genome project and the future of oncology
International Nuclear Information System (INIS)
Collins, Francis S.
1996-01-01
The Human Genome Project is an ambitious 15-year effort to devise maps and sequence of the 3-billion base pair human genome, including all 100,000 genes. The project is running ahead of schedule and under budget. Already the effects on progress in disease gene discovery have been dramatic, especially for cancer. The most appropriate uses of susceptibility testing for breast, ovarian, and colon cancer are being investigated in research protocols, and the need to prevent genetic discrimination in employment and health insurance is becoming more urgent. In the longer term, these gene discoveries are likely to usher in a new era of therapeutic molecular medicine
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Initiating a Human Variome Project Country Node.
AlAama, Jumana; Smith, Timothy D; Lo, Alan; Howard, Heather; Kline, Alexandria A; Lange, Matthew; Kaput, Jim; Cotton, Richard G H
2011-05-01
Genetic diseases are a pressing global health problem that requires comprehensive access to basic clinical and genetic data to counter. The creation of regional and international databases that can be easily accessed by clinicians and diagnostic labs will greatly improve our ability to accurately diagnose and treat patients with genetic disorders. The Human Variome Project is currently working in conjunction with human genetics societies to achieve this by establishing systems to collect every mutation reported by a diagnostic laboratory, clinic, or research laboratory in a country and store these within a national repository, or HVP Country Node. Nodes have already been initiated in Australia, Belgium, China, Egypt, Malaysia, and Kuwait. Each is examining how to systematically collect and share genetic, clinical, and biochemical information in a country-specific manner that is sensitive to local ethical and cultural issues. This article gathers cases of genetic data collection within countries and takes recommendations from the global community to develop a procedure for countries wishing to establish their own collection system as part of the Human Variome Project. We hope this may lead to standard practices to facilitate global collection of data and allow efficient use in clinical practice, research and therapy. © 2011 Wiley-Liss, Inc.
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Justice and the Human Genome Project
Energy Technology Data Exchange (ETDEWEB)
Murphy, T.F.; Lappe, M. (eds.)
1992-01-01
Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.
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Justice and the Human Genome Project
Energy Technology Data Exchange (ETDEWEB)
Murphy, T.F.; Lappe, M. [eds.
1992-12-31
Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.
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Human exploration of NEA: why and how?
Viscio, M. A.; Casacci, C.; Ferro, C.
The human exploration of multiple deep space destinations, and among them Near Earth Asteroids (NEA), in view of the final challenge of sending astronauts to Mars, represents a current and consistent study domain. NEAs represent interesting targets, not only for the high level scientific return of such missions, but also for advanced technologies demonstration. Accordingly, the NEA mission described in this paper is conceived as an intermediate step before a human mission to the Red Planet and, in this regard, several technologies required for Mars are implemented, in order to test and validate them in significant environment, but at a closer and easier destination. Another crucial aspect to be considered, when dealing with asteroids, is related to planetary defense: even if the probability of an impact with the Earth is very low, this possibility does actually exist. A human mission as the one described in this paper would represent a chance for the development and test of technologies and techniques to be used for asteroid collision avoidance. The paper starts discussing the main objectives of a NEA mission, highlighting the benefits of the human presence. A reference human mission is then described, in terms of strategy, architecture and concept of operations, with particular attention to NEA collision avoidance issue. In the last part, the idea of exploiting virtual reality in support of the mission definition and execution is discussed.
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2012-06-07
... and Human Resources Project Monitoring Clearance AGENCY: National Science Foundation. ACTION: Notice...). SUPPLEMENTARY INFORMATION: Title of Collection: Education and Human Resources Project Monitoring Clearance. OMB... States and internationally. The Directorate for Education and Human Resources (EHR), a unit within NSF...
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Levine, Joel S.; Croom, Mark A.; Wright, Henry S.; Killough, B. D.; Edwards, W. C.
2012-01-01
Obtaining critical measurements for eventual human Mars missions while expanding upon recent Mars scientific discoveries and deriving new scientific knowledge from a unique near surface vantage point is the focus of the Aerial Regional-scale Environmental Surveyor (ARES) exploration mission. The key element of ARES is an instrumented,rocket-powered, well-tested robotic airplane platform, that will fly between one to two kilometers above the surface while traversing hundreds of kilometers to collect and transmit previously unobtainable high spatial measurements relevant to the NASA Mars Exploration Program and the exploration of Mars by humans.
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Modeling and Simulation for Exploring Human-Robot Team Interaction Requirements
Energy Technology Data Exchange (ETDEWEB)
Dudenhoeffer, Donald Dean; Bruemmer, David Jonathon; Davis, Midge Lee
2001-12-01
Small-sized and micro-robots will soon be available for deployment in large-scale forces. Consequently, the ability of a human operator to coordinate and interact with largescale robotic forces is of great interest. This paper describes the ways in which modeling and simulation have been used to explore new possibilities for human-robot interaction. The paper also discusses how these explorations have fed implementation of a unified set of command and control concepts for robotic force deployment. Modeling and simulation can play a major role in fielding robot teams in actual missions. While live testing is preferred, limitations in terms of technology, cost, and time often prohibit extensive experimentation with physical multi-robot systems. Simulation provides insight, focuses efforts, eliminates large areas of the possible solution space, and increases the quality of actual testing.
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Modeling Operations Costs for Human Exploration Architectures
Shishko, Robert
2013-01-01
Operations and support (O&S) costs for human spaceflight have not received the same attention in the cost estimating community as have development costs. This is unfortunate as O&S costs typically comprise a majority of life-cycle costs (LCC) in such programs as the International Space Station (ISS) and the now-cancelled Constellation Program. Recognizing this, the Constellation Program and NASA HQs supported the development of an O&S cost model specifically for human spaceflight. This model, known as the Exploration Architectures Operations Cost Model (ExAOCM), provided the operations cost estimates for a variety of alternative human missions to the moon, Mars, and Near-Earth Objects (NEOs) in architectural studies. ExAOCM is philosophically based on the DoD Architecture Framework (DoDAF) concepts of operational nodes, systems, operational functions, and milestones. This paper presents some of the historical background surrounding the development of the model, and discusses the underlying structure, its unusual user interface, and lastly, previous examples of its use in the aforementioned architectural studies.
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Automation and robotics for the Space Exploration Initiative: Results from Project Outreach
Gonzales, D.; Criswell, D.; Heer, E.
1991-01-01
A total of 52 submissions were received in the Automation and Robotics (A&R) area during Project Outreach. About half of the submissions (24) contained concepts that were judged to have high utility for the Space Exploration Initiative (SEI) and were analyzed further by the robotics panel. These 24 submissions are analyzed here. Three types of robots were proposed in the high scoring submissions: structured task robots (STRs), teleoperated robots (TORs), and surface exploration robots. Several advanced TOR control interface technologies were proposed in the submissions. Many A&R concepts or potential standards were presented or alluded to by the submitters, but few specific technologies or systems were suggested.
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Project management for humans helping people get things done
Harned, Brett
2017-01-01
Project management—it’s not just about following a template or using a tool, but rather developing personal skills and intuition to find a method that works for everyone. Whether you’re a designer or a manager, Project Management for Humans will help you estimate and plan tasks, scout and address issues before they become problems, and communicate with and hold people accountable.
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ExoHab Pilot Project & Field Tests for Moon-Mars Human Laboratories
Foing, Bernard
2010-05-01
We studied concepts for a minimal Moon-Mars habitat, in focussing on the system aspects and coordinating every different part as part an evolving architecture. We validated experimentally the Habitat and Laboratory ExoHab concept constraints during EuroGeoMars campaign in Utah desert research station (from 24 Jan. to 28 Feb. 2009) and EuroMoonMars/DOMMEX campaigns in Nov 2009 and February-April 2010. We discuss from the ILEWG ExoHab concept studies and field simulations the specifics of human exploration, with focus on habitability and human performance. In the ExoHab pilot concept project (supported by ILEWG, ESA NASA), we justify the case for a scientific and exploration outpost allowing experiments, sample analysis in laboratory (relevant to the origin and evolution of planets and life, geophysical and geo-chemical studies, astrobiology and life sciences, observation sciences, technology demonstration, resource utilisation, human exploration and settlement). In this modular concept, we consider various infra structure elements: core habitat, Extra Vehicular activity (EVA), crew mobility, energy supply, recycling module, communication, green house and food production, operations. We review some studies space agencies' architecture proposals, with landers, orbiters, rovers, habitats, surface operations and protocols. We focus on the easiest and the soonest way in settling a minimal base immediately operational in scientific experimentation and exploration, but not immediately autonomous. Through a modular concept, this outpost will be possibly evolved into a long duration or permanent base. We will analyse the possibilities of settling such a minimal base by means of the current and near term propulsion technology, as a full Ariane 5 ME carrying 1.7 T of gross payload to the surface of the Moon (Integrated Exploration Study, ESA ESTEC [1,2]). The low solar rays incidence may permit having ice in deep craters, which will be beneficial for the evolution of the
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Performance of humans vs. exploration algorithms on the Tower of London Test.
Directory of Open Access Journals (Sweden)
Eric Fimbel
Full Text Available The Tower of London Test (TOL used to assess executive functions was inspired in Artificial Intelligence tasks used to test problem-solving algorithms. In this study, we compare the performance of humans and of exploration algorithms. Instead of absolute execution times, we focus on how the execution time varies with the tasks and/or the number of moves. This approach used in Algorithmic Complexity provides a fair comparison between humans and computers, although humans are several orders of magnitude slower. On easy tasks (1 to 5 moves, healthy elderly persons performed like exploration algorithms using bounded memory resources, i.e., the execution time grew exponentially with the number of moves. This result was replicated with a group of healthy young participants. However, for difficult tasks (5 to 8 moves the execution time of young participants did not increase significantly, whereas for exploration algorithms, the execution time keeps on increasing exponentially. A pre-and post-test control task showed a 25% improvement of visuo-motor skills but this was insufficient to explain this result. The findings suggest that naive participants used systematic exploration to solve the problem but under the effect of practice, they developed markedly more efficient strategies using the information acquired during the test.
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Human missions to Mars enabling technologies for exploring the red planet
Rapp, Donald
2016-01-01
A mission to send humans to explore the surface of Mars has been the ultimate goal of planetary exploration since the 1950s, when von Braun conjectured a flotilla of 10 interplanetary vessels carrying a crew of at least 70 humans. Since then, more than 1,000 studies were carried out on human missions to Mars, but after 60 years of study, we remain in the early planning stages. The second edition of this book now includes an annotated history of Mars mission studies, with quantitative data wherever possible. Retained from the first edition, Donald Rapp looks at human missions to Mars from an engineering perspective. He divides the mission into a number of stages: Earth’s surface to low-Earth orbit (LEO); departing from LEO toward Mars; Mars orbit insertion and entry, descent and landing; ascent from Mars; trans-Earth injection from Mars orbit and Earth return. For each segment, he analyzes requirements for candidate technologies. In this connection, he discusses the status and potential of a wide range of el...
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Directory of Open Access Journals (Sweden)
Lin He
2017-12-01
Full Text Available In line with the constraints of environmental problems and economic development, large-scale renewable-generation projects have been planned and constructed in recent years. In order to achieve sustainable power development and improve the power supply structure, China’s government has focused on distributed photovoltaic (PV generation projects due to their advantages of clean emission and local consumption. However, their unstable output power still brings a series of problems concerning reliability, investment income, and available substitution proportion to traditional power, and so on. Therefore, it is imperative to understand the competitive development abilities of distributed PV generation projects and measure them effectively. First, through various investigation methods such as literature reviews, feasibility report analysis and expert interviews, the factors that influence the core abilities of distributed PV-generation projects were explored based on the micro-grid structure. Then, with the indexed exploration results, the factors were classified into 6 dimensions, i.e., investment and earning ability, production and operation ability, power-grid coordination ability, energy-conservation and emission-reduction ability, sustainable development ability, and society-serving ability. Meanwhile, an evaluation index system for core abilities of distributed PV-generation project was constructed using all quantitative indicators. Third, for examining the availability of the evaluation index system, combination weighting and techniques for order preference by similarity to an ideal solution (TOPSIS methods were adopted to assess the practical distributed PV-generation projects. The case study results showed that installed capacity, local economy development, and grid-connected power quantity will influence the core abilities of distributed PV-generation project, obviously. The conclusions of the evaluation analysis on core abilities can
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The Shaky Legal Foundations of the Global Human Rights Education Project
Vlaardingerbroek, Barend
2015-01-01
School students should be taught about the law and this includes rights education. The global human rights education (HRE) project focuses on universal human rights and has a strongly utopian orientation, drawing as it does on international declarations and principles of human rights law. International human rights law is, however, at best a…
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Genes, Environment, and Human Behavior.
Bloom, Mark V.; Cutter, Mary Ann; Davidson, Ronald; Dougherty, Michael J.; Drexler, Edward; Gelernter, Joel; McCullough, Laurence B.; McInerney, Joseph D.; Murray, Jeffrey C.; Vogler, George P.; Zola, John
This curriculum module explores genes, environment, and human behavior. This book provides materials to teach about the nature and methods of studying human behavior, raise some of the ethical and public policy dilemmas emerging from the Human Genome Project, and provide professional development for teachers. An extensive Teacher Background…
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Drake, Bret G. (Editor)
1998-01-01
This Addendum to the Mars Reference Mission was developed as a companion document to the NASA Special Publication 6107, "Human Exploration of Mars: The Reference Mission of the NASA Mars Exploration Study Team." It summarizes changes and updates to the Mars Reference Missions that were developed by the Exploration Office since the final draft of SP 6107 was printed in early 1999. The Reference Mission is a tool used by the exploration community to compare and evaluate approaches to mission and system concepts that could be used for human missions to Mars. It is intended to identify and clarify system drivers, significant sources of cost, performance, risk, and schedule variation. Several alternative scenarios, employing different technical approaches to solving mission and technology challenges, are discussed in this Addendum. Comparing alternative approaches provides the basis for continual improvement to technology investment plan and a general understanding of future human missions to Mars. The Addendum represents a snapshot of work in progress in support of planning for future human exploration missions through May 1998.
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Lunar Polar In Situ Resource Utilization (ISRU) as a Stepping Stone for Human Exploration
Sanders, Gerald B.
2013-01-01
A major emphasis of NASA is to extend and expand human exploration across the solar system. While specific destinations are still being discussed as to what comes first, it is imperative that NASA create new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable exploration beyond low Earth orbit (LEO) are the development of technologies and approaches for advanced robotics, power, propulsion, habitats, life support, and especially, space resource utilization systems. Space resources and how to use them, often called In-Situ Resource Utilization (ISRU), can have a tremendous beneficial impact on robotic and human exploration of the Moon, Mars, Phobos, and Near Earth Objects (NEOs), while at the same time helping to solve terrestrial challenges and enabling commercial space activities. The search for lunar resources, demonstration of extraterrestrial mining, and the utilization of resource-derived products, especially from polar volatiles, can be a stepping stone for subsequent human exploration missions to other destinations of interest due to the proximity of the Moon, complimentary environments and resources, and the demonstration of critical technologies, processes, and operations. ISRU and the Moon: There are four main areas of development interest with respect to finding, obtaining, extracting, and using space resources: Prospecting for resources, Production of mission critical consumables like propellants and life support gases, Civil engineering and construction, and Energy production, storage, and transfer. The search for potential resources and the production of mission critical consumables are the primary focus of current NASA technology and system development activities since they provide the greatest initial reduction in mission mass, cost, and risk. Because of the proximity of the Moon, understanding lunar resources and developing, demonstrating, and implementing lunar ISRU
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Intelligent (Autonomous) Power Controller Development for Human Deep Space Exploration
Soeder, James; Raitano, Paul; McNelis, Anne
2016-01-01
As NASAs Evolvable Mars Campaign and other exploration initiatives continue to mature they have identified the need for more autonomous operations of the power system. For current human space operations such as the International Space Station, the paradigm is to perform the planning, operation and fault diagnosis from the ground. However, the dual problems of communication lag as well as limited communication bandwidth beyond GEO synchronous orbit, underscore the need to change the operation methodology for human operation in deep space. To address this need, for the past several years the Glenn Research Center has had an effort to develop an autonomous power controller for human deep space vehicles. This presentation discusses the present roadmap for deep space exploration along with a description of conceptual power system architecture for exploration modules. It then contrasts the present ground centric control and management architecture with limited autonomy on-board the spacecraft with an advanced autonomous power control system that features ground based monitoring with a spacecraft mission manager with autonomous control of all core systems, including power. It then presents a functional breakdown of the autonomous power control system and examines its operation in both normal and fault modes. Finally, it discusses progress made in the development of a real-time power system model and how it is being used to evaluate the performance of the controller and well as using it for verification of the overall operation.
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Classification of human- and automated resource allocation approaches in multi-project management
Ponsteen, A.; Kusters, R.J.; Pasian, B.; Storm, P.
2015-01-01
Managing a multi-project environment requires a different method than managing a single project. The main challenge of managing a multi-project environment is the allocation of scarce human resources over the projects in execution. As part of a broader research on this topic, the aim of this paper
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Drone-Augmented Human Vision: Exocentric Control for Drones Exploring Hidden Areas.
Erat, Okan; Isop, Werner Alexander; Kalkofen, Denis; Schmalstieg, Dieter
2018-04-01
Drones allow exploring dangerous or impassable areas safely from a distant point of view. However, flight control from an egocentric view in narrow or constrained environments can be challenging. Arguably, an exocentric view would afford a better overview and, thus, more intuitive flight control of the drone. Unfortunately, such an exocentric view is unavailable when exploring indoor environments. This paper investigates the potential of drone-augmented human vision, i.e., of exploring the environment and controlling the drone indirectly from an exocentric viewpoint. If used with a see-through display, this approach can simulate X-ray vision to provide a natural view into an otherwise occluded environment. The user's view is synthesized from a three-dimensional reconstruction of the indoor environment using image-based rendering. This user interface is designed to reduce the cognitive load of the drone's flight control. The user can concentrate on the exploration of the inaccessible space, while flight control is largely delegated to the drone's autopilot system. We assess our system with a first experiment showing how drone-augmented human vision supports spatial understanding and improves natural interaction with the drone.
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The human genome project and the future of medical practice ...
African Journals Online (AJOL)
Contrary to the scepticism that characterised the planning stages of the human genome project, the technology and sequence data resulting from the project are set to revolutionise medical practice for good. The expected benefits include: enhanced discovery of disease genes, which will lead to improved knowledge on the ...
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Addressing Human System Risks to Future Space Exploration
Paloski, W. H.; Francisco, D. R.; Davis, J. R.
2015-01-01
NASA is contemplating future human exploration missions to destinations beyond low Earth orbit, including the Moon, deep-space asteroids, and Mars. While we have learned much about protecting crew health and performance during orbital space flight over the past half-century, the challenges of these future missions far exceed those within our current experience base. To ensure success in these missions, we have developed a Human System Risk Board (HSRB) to identify, quantify, and develop mitigation plans for the extraordinary risks associated with each potential mission scenario. The HSRB comprises research, technology, and operations experts in medicine, physiology, psychology, human factors, radiation, toxicology, microbiology, pharmacology, and food sciences. Methods: Owing to the wide range of potential mission characteristics, we first identified the hazards to human health and performance common to all exploration missions: altered gravity, isolation/confinement, increased radiation, distance from Earth, and hostile/closed environment. Each hazard leads to a set of risks to crew health and/or performance. For example the radiation hazard leads to risks of acute radiation syndrome, central nervous system dysfunction, soft tissue degeneration, and carcinogenesis. Some of these risks (e.g., acute radiation syndrome) could affect crew health or performance during the mission, while others (e.g., carcinogenesis) would more likely affect the crewmember well after the mission ends. We next defined a set of design reference missions (DRM) that would span the range of exploration missions currently under consideration. In addition to standard (6-month) and long-duration (1-year) missions in low Earth orbit (LEO), these DRM include deep space sortie missions of 1 month duration, lunar orbital and landing missions of 1 year duration, deep space journey and asteroid landing missions of 1 year duration, and Mars orbital and landing missions of 3 years duration. We then
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Nuclear human resource projection up to 2030 in KOREA
International Nuclear Information System (INIS)
Min, Byung Joo; Lee, Man Ki; Nam, Kee Yung; Jeong, Ki Ho
2011-01-01
The prospects for growth of the nuclear power industry in Korea have improved remarkably as the demand for energy increases in stride with economic development. Meanwhile, as nuclear energy development is enhanced, nuclear technology has also improved evolutionarily and innovatively in the areas of reactor design and safety measures. As nuclear technology development in Korea advances, more human resources are required. Accordingly, the need for a well-managed program of human resource development (HRD) aimed at assuring needed capacities, skills, and knowledge and maintaining valuable human resources through education and training in various nuclear-related fields has been recognized. A well-defined and object-oriented human resource development and management (HRD and M) is to be developed in order to balance between the dynamics of supply and demand of the workforce in the nuclear industry. The HRD and M schemes include a broad base of disciplines, education, sciences, and technologies within a framework of national sustainable development goals, which are generally considered to include economics, environment, and social concerns. In this study, the projection methodology considering a variety of economic, social, and environmental factors was developed. Using the developed methodology, medium- and long-term nuclear human resources projections up to 2030 were conducted in compliance with the national nuclear technology development programmes and plans
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A decade of human genome project conclusion: Scientific diffusion about our genome knowledge.
Moraes, Fernanda; Góes, Andréa
2016-05-06
The Human Genome Project (HGP) was initiated in 1990 and completed in 2003. It aimed to sequence the whole human genome. Although it represented an advance in understanding the human genome and its complexity, many questions remained unanswered. Other projects were launched in order to unravel the mysteries of our genome, including the ENCyclopedia of DNA Elements (ENCODE). This review aims to analyze the evolution of scientific knowledge related to both the HGP and ENCODE projects. Data were retrieved from scientific articles published in 1990-2014, a period comprising the development and the 10 years following the HGP completion. The fact that only 20,000 genes are protein and RNA-coding is one of the most striking HGP results. A new concept about the organization of genome arose. The ENCODE project was initiated in 2003 and targeted to map the functional elements of the human genome. This project revealed that the human genome is pervasively transcribed. Therefore, it was determined that a large part of the non-protein coding regions are functional. Finally, a more sophisticated view of chromatin structure emerged. The mechanistic functioning of the genome has been redrafted, revealing a much more complex picture. Besides, a gene-centric conception of the organism has to be reviewed. A number of criticisms have emerged against the ENCODE project approaches, raising the question of whether non-conserved but biochemically active regions are truly functional. Thus, HGP and ENCODE projects accomplished a great map of the human genome, but the data generated still requires further in depth analysis. © 2016 by The International Union of Biochemistry and Molecular Biology, 44:215-223, 2016. © 2016 The International Union of Biochemistry and Molecular Biology.
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Project Selection for NASA's R&D Programs
Jones, Harry
2005-01-01
The purpose of NASA s Research and Development (R&D) programs is to provide advanced human support technologies for the Exploration Systems Mission Directorate (ESMD). The new technologies must be sufficiently attractive and proven to be selectable for future missions. This requires identifying promising candidate technologies and advancing them in technology readiness until they are likely options for flight. The R&D programs must select an array of technology development projects, manage them, and either terminate or continue them, so as to maximize the delivered number of potentially usable advanced human support technologies. This paper proposes an effective project selection methodology to help manage NASA R&D project portfolios.
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2013-04-05
... topics: --Overview of Research in Space Life and Physical Sciences --Space Station and Future Exploration... Exploration and Operations Committee; Research Subcommittee; Meeting AGENCY: National Aeronautics and Space... of the Research Subcommittee of the Human Exploration and Operations Committee (HEOC) of the NASA...
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Magnaye, Romulo; Tan, Weiping; Ramirez-Marquez, Jose; Sauser, Bruce
2010-01-01
The Exploration Systems Mission Directorate of the National Aeronautics and Space Administration (NASA) is currently pursuing the development of the next generation of human spacecraft and exploration systems throughout the Constellation Program. This includes, among others, habitation technologies for supporting lunar and Mars exploration. The key to these systems is the Exploration Life Support (ELS) system that composes several technology development projects related to atmosphere revitalization, water recovery, waste management and habitation. The proper functioning of these technologies is meant to produce sufficient and balanced resources of water, air, and food to maintain a safe and comfortable environment for long-term human habitation and exploration of space.
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HExpoChem: a systems biology resource to explore human exposure to chemicals
DEFF Research Database (Denmark)
Taboureau, Olivier; Jacobsen, Ulrik Plesner; Kalhauge, Christian Gram
2013-01-01
of computational biology approaches are needed to assess the health risks of chemical exposure. Here we present HExpoChem, a tool based on environmental chemicals and their bioactivities on human proteins with the objective of aiding the qualitative exploration of human exposure to chemicals. The chemical...
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The Trust Project - Symbiotic Human Machine Teams: Social Cueing for Trust and Reliance
2016-06-30
AFRL-RH-WP-TR-2016-0096 THE TRUST PROJECT - SYMBIOTIC HUMAN-MACHINE TEAMS: SOCIAL CUEING FOR TRUST & RELIANCE Susan Rivers, Monika Lohani, Marissa...30 JUN 2012 – 30 JUN 2016 4. TITLE AND SUBTITLE THE TRUST PROJECT - SYMBIOTIC HUMAN-MACHINE TEAMS: SOCIAL CUEING FOR TRUST & RELIANCE 5a. CONTRACT
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Williams-Byrd, Julie; Arney, Dale C.; Hay, Jason; Reeves, John D.; Craig, Douglas
2016-01-01
NASA is transforming human spaceflight. The Agency is shifting from an exploration-based program with human activities in low Earth orbit (LEO) and targeted robotic missions in deep space to a more sustainable and integrated pioneering approach. Through pioneering, NASA seeks to address national goals to develop the capacity for people to work, learn, operate, live, and thrive safely beyond Earth for extended periods of time. However, pioneering space involves daunting technical challenges of transportation, maintaining health, and enabling crew productivity for long durations in remote, hostile, and alien environments. Prudent investments in capability and technology developments, based on mission need, are critical for enabling a campaign of human exploration missions. There are a wide variety of capabilities and technologies that could enable these missions, so it is a major challenge for NASA's Human Exploration and Operations Mission Directorate (HEOMD) to make knowledgeable portfolio decisions. It is critical for this pioneering initiative that these investment decisions are informed with a prioritization process that is robust and defensible. It is NASA's role to invest in targeted technologies and capabilities that would enable exploration missions even though specific requirements have not been identified. To inform these investments decisions, NASA's HEOMD has supported a variety of analysis activities that prioritize capabilities and technologies. These activities are often based on input from subject matter experts within the NASA community who understand the technical challenges of enabling human exploration missions. This paper will review a variety of processes and methods that NASA has used to prioritize and rank capabilities and technologies applicable to human space exploration. The paper will show the similarities in the various processes and showcase instances were customer specified priorities force modifications to the process. Specifically
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Human Exploration and Development in the Solar System
Mendell, Wendell
2017-05-01
Emergence of ballistic missile technology after the Second World War enabled human flight into Earth's orbit, fueling the imagination of those fascinated with science, technology, exploration, and adventure. The performance of astronauts in the early flights assuaged concerns about the functioning of "the human system" in the absence of normal gravity. However, researchers in space medicine have observed degradation of crews after longer exposure to the space environment and have developed countermeasures for most of them, although significant challenges remain. With the dawn of the 21st century, well-financed and technically competent commercial entities began to provide more affordable alternatives to historically expensive and risk-averse government-funded programs. Space's growing accessibility has encouraged entrepreneurs to pursue plans for potentially autarkic communities beyond Earth, exploiting natural resources on other worlds. Should such dreams prove to be technically and economically feasible, a new era will open for humanity with concomitant societal issues of a revolutionary nature.
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International Nuclear Information System (INIS)
1999-02-01
BP Exploration (Alaska) Inc. (BPXA) submitted a permit application to the US Army Engineer District, Alaska to initiate the review process for BPXA's plans to develop and produce oil and gas from the Northstar Unit. This report contains Appendix A of an Environmental Impact Statement which was undertaken to identify and evaluate the potential effects the proposed project may have on the environment. This document is the Northstar Development Project, Final Project Description, Revision 1 for BPXA Northstar Project
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Abell, P. A.; Rivkin, A. S.
2015-01-01
Introduction: Robotic reconnaissance missions to small bodies will directly address aspects of NASA's Asteroid Initiative and will contribute to future human exploration. The NASA Asteroid Initiative is comprised of two major components: the Grand Challenge and the Asteroid Mission. The first component, the Grand Challenge, focuses on protecting Earth's population from asteroid impacts by detecting potentially hazardous objects with enough warning time to either prevent them from impacting the planet, or to implement civil defense procedures. The Asteroid Mission involves sending astronauts to study and sample a near- Earth asteroid (NEA) prior to conducting exploration missions of the Martian system, which includes Phobos and Deimos. The science and technical data obtained from robotic precursor missions that investigate the surface and interior physical characteristics of an object will help identify the pertinent physical properties that will maximize operational efficiency and reduce mission risk for both robotic assets and crew operating in close proximity to, or at the surface of, a small body. These data will help fill crucial strategic knowledge gaps (SKGs) concerning asteroid physical characteristics that are relevant for human exploration considerations at similar small body destinations. Small Body Strategic Knowledge Gaps: For the past several years NASA has been interested in identifying the key SKGs related to future human destinations. These SKGs highlight the various unknowns and/or data gaps of targets that the science and engineering communities would like to have filled in prior to committing crews to explore the Solar System. An action team from the Small Bodies Assessment Group (SBAG) was formed specifically to identify the small body SKGs under the direction of the Human Exploration and Operations Missions Directorate (HEOMD), given NASA's recent interest in NEAs and the Martian moons as potential human destinations [1]. The action team
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Gore, Brian F.
2016-01-01
Human space exploration has never been more exciting than it is today. Human presence to outer worlds is becoming a reality as humans are leveraging much of our prior knowledge to the new mission of going to Mars. Exploring the solar system at greater distances from Earth than ever before will possess some unique challenges, which can be overcome thanks to the advances in modeling and simulation technologies. The National Aeronautics and Space Administration (NASA) is at the forefront of exploring our solar system. NASA's Human Research Program (HRP) focuses on discovering the best methods and technologies that support safe and productive human space travel in the extreme and harsh space environment. HRP uses various methods and approaches to answer questions about the impact of long duration missions on the human in space including: gravity's impact on the human body, isolation and confinement on the human, hostile environments impact on the human, space radiation, and how the distance is likely to impact the human. Predictive models are included in the HRP research portfolio as these models provide valuable insights into human-system operations. This paper will provide an overview of NASA's HRP and will present a number of projects that have used modeling and simulation to provide insights into human-system issues (e.g. automation, habitat design, schedules) in anticipation of space exploration.
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Finding Near-Earth Asteroid (NEA) Destinations for Human Exploration: Implications for Astrobiology
Landis, Rob; Abell, Paul; Barbee, Brent; Johnson, Lindley
2012-01-01
The current number of known potential NEA targets for HSF is limited to those objects whose orbital characteristics are similar to that of the Earth. This is due to the projected capabilities of the exploration systems currently under consideration and development at NASA. However, NEAs with such orbital characteristics often have viewing geometries that place them at low solar elongations and thus are difficult to detect from the vicinity of Earth. While ongoing ground-based surveys and data archives maintained by the NEO Program Observation Program Office and the Minor Planet Center (MPC) have provided a solid basis upon which to build, a more complete catalog of the NEO population is required to inform a robust and sustainable HSF exploration program. Since all the present NEO observing assets are currently confined to the vicinity of the Earth, additional effort must be made to provide capabilities for detection of additional HSF targets via assets beyond Earth orbit. A space-based NEO survey telescope located beyond the vicinity of the Earth, has considerable implications for planetary science and astrobiology. Such a telescope will provide foundational knowledge of our Solar System small body population and detect targets of interest for both the HSF and scientific communities. Data from this asset will yield basic characterization data on the NEOs observed (i.e., albedo, size determination, potential for volatiles and organics, etc.) and help down select targets for future HSF missions. Ideally, the most attractive targets from both HSF and astrobiology perspectives are those NEAs that may contain organic and volatile materials, and which could be effectively sampled at a variety of locations and depths. Presented here is an overview of four space-based survey concepts; any one of which after just a few years of operation will discover many highly accessible NEO targets suitable for robotic and human exploration. Such a space-based survey mission will reveal
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Reconsidering democracy - History of the human genome project
Huijer, M
What options are open for people-citizens, politicians, and other nonscientists-to become actively involved in and anticipate new directions in the life sciences? In addressing this question, this article focuses on the start of the Human Genome Project (1985-1990). By contrasting various models of
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Exploring Human Cognition Using Large Image Databases.
Griffiths, Thomas L; Abbott, Joshua T; Hsu, Anne S
2016-07-01
Most cognitive psychology experiments evaluate models of human cognition using a relatively small, well-controlled set of stimuli. This approach stands in contrast to current work in neuroscience, perception, and computer vision, which have begun to focus on using large databases of natural images. We argue that natural images provide a powerful tool for characterizing the statistical environment in which people operate, for better evaluating psychological theories, and for bringing the insights of cognitive science closer to real applications. We discuss how some of the challenges of using natural images as stimuli in experiments can be addressed through increased sample sizes, using representations from computer vision, and developing new experimental methods. Finally, we illustrate these points by summarizing recent work using large image databases to explore questions about human cognition in four different domains: modeling subjective randomness, defining a quantitative measure of representativeness, identifying prior knowledge used in word learning, and determining the structure of natural categories. Copyright © 2016 Cognitive Science Society, Inc.
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Unmanned systems to support the human exploration of Mars
Gage, Douglas W.
2010-04-01
Robots and other unmanned systems will play many critical roles in support of a human presence on Mars, including surveying candidate landing sites, locating ice and mineral resources, establishing power and other infrastructure, performing construction tasks, and transporting equipment and supplies. Many of these systems will require much more strength and power than exploration rovers. The presence of humans on Mars will permit proactive maintenance and repair, and allow teleoperation and operator intervention, supporting multiple dynamic levels of autonomy, so the critical challenges to the use of unmanned systems will occur before humans arrive on Mars. Nevertheless, installed communications and navigation infrastructure should be able to support structured and/or repetitive operations (such as excavation, drilling, or construction) within a "familiar" area with an acceptable level of remote operator intervention. This paper discusses some of the factors involved in developing and deploying unmanned systems to make humans' time on Mars safer and more productive, efficient, and enjoyable.
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Standard guidelines for the chromosome-centric human proteome project.
Paik, Young-Ki; Omenn, Gilbert S; Uhlen, Mathias; Hanash, Samir; Marko-Varga, György; Aebersold, Ruedi; Bairoch, Amos; Yamamoto, Tadashi; Legrain, Pierre; Lee, Hyoung-Joo; Na, Keun; Jeong, Seul-Ki; He, Fuchu; Binz, Pierre-Alain; Nishimura, Toshihide; Keown, Paul; Baker, Mark S; Yoo, Jong Shin; Garin, Jerome; Archakov, Alexander; Bergeron, John; Salekdeh, Ghasem Hosseini; Hancock, William S
2012-04-06
The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-HPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing colocated genes and their protein products. The C-HPP aims to foster the development of proteome analysis and integration of the findings from related molecular -omics technology platforms through collaborations among universities, industries, and private research groups. The C-HPP consortium leadership has elicited broad input for standard guidelines to manage these international efforts more efficiently by mobilizing existing resources and collaborative networks. The C-HPP guidelines set out the collaborative consensus of the C-HPP teams, introduce topics associated with experimental approaches, data production, quality control, treatment, and transparency of data, governance of the consortium, and collaborative benefits. A companion approach for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome Project is currently being organized, building upon the Human Proteome Organization's organ-based and biofluid-based initiatives (www.hupo.org/research). The common application of these guidelines in the participating laboratories is expected to facilitate the goal of a comprehensive analysis of the human proteome.
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TRI-Worthy Projects for the Deep Space Gateway
Wotring, V. E.; Strangman, G. E.; Donoviel, D.
2018-02-01
Preparations for exploration will require exposure to the actual deep space environment. The new TRI for Space Health proposes innovative projects using real space radiation to make medically-relevant measurements affecting human physiology.
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Reconsidering democracy. History of the Human Genome Project.
Marli Huijer
2003-01-01
What options are open for peoplecitizens, politicians, and other nonscientiststo become actively involved in and anticipate new directions in the life sciences? In addressing this question, this article focuses on the start of the Human Genome Project (1985-1990). By contrasting various models of
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Palaszewski, Bryan
2015-01-01
Human and robotic missions to Mercury and Saturn are presented and analyzed. Unique elements of the local planetary environments are discussed and included in the analyses and assessments. Using historical studies of space exploration, in-situ resource utilization (ISRU), and industrialization all point to the vastness of natural resources in the solar system. Advanced propulsion benefitted from these resources in many way. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal and nuclear pulse propulsion as well as advanced chemical propulsion can significantly enhance these scenarios. Updated analyses based on these historical visions will be presented. Nuclear thermal propulsion and ISRU enhanced chemical propulsion landers are assessed for Mercury missions. At Saturn, nuclear pulse propulsion with alternate propellant feed systems and Titan exploration with chemical propulsion options are discussed.
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Exploration Medical Capability - Technology Watch
Krihak, Michael; Watkins, Sharmila; Barr, Yael; Barsten, Kristina; Fung, Paul; Baumann, David
2011-01-01
The objectives of the Technology Watch process are to identify emerging, high-impact technologies that augment current ExMC development efforts, and to work with academia, industry, and other government agencies to accelerate the development of medical care and research capabilities for the mitigation of potential health issues that could occur during space exploration missions. The establishment of collaborations with these entities is beneficial to technology development, assessment and/or insertion. Such collaborations also further NASA s goal to provide a safe and healthy environment for human exploration. The Tech Watch project addresses requirements and capabilities identified by knowledge and technology gaps that are derived from a discrete set of medical conditions that are most likely to occur on exploration missions. These gaps are addressed through technology readiness level assessments, market surveys, collaborations and distributed innovation opportunities. Ultimately, these gaps need to be closed with respect to exploration missions, and may be achieved through technology development projects. Information management is a key aspect to this process where Tech Watch related meetings, research articles, collaborations and partnerships are tracked by the HRP s Exploration Medical Capabilities (ExMC) Element. In 2011, ExMC will be introducing the Tech Watch external website and evidence wiki that will provide access to ExMC technology and knowledge gaps, technology needs and requirements documents.
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Connecting the Human Variome Project to nutrigenomics.
Kaput, Jim; Evelo, Chris T; Perozzi, Giuditta; van Ommen, Ben; Cotton, Richard
2010-12-01
Nutrigenomics is the science of analyzing and understanding gene-nutrient interactions, which because of the genetic heterogeneity, varying degrees of interaction among gene products, and the environmental diversity is a complex science. Although much knowledge of human diversity has been accumulated, estimates suggest that ~90% of genetic variation has not yet been characterized. Identification of the DNA sequence variants that contribute to nutrition-related disease risk is essential for developing a better understanding of the complex causes of disease in humans, including nutrition-related disease. The Human Variome Project (HVP; http://www.humanvariomeproject.org/) is an international effort to systematically identify genes, their mutations, and their variants associated with phenotypic variability and indications of human disease or phenotype. Since nutrigenomic research uses genetic information in the design and analysis of experiments, the HVP is an essential collaborator for ongoing studies of gene-nutrient interactions. With the advent of next generation sequencing methodologies and the understanding of the undiscovered variation in human genomes, the nutrigenomic community will be generating novel sequence data and results. The guidelines and practices of the HVP can guide and harmonize these efforts.
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Crabby Interactions: Fifth Graders Explore Human Impact on the Blue Crab Population
Jeffery, Tonya D.; McCollough, Cherie A.; Moore, Kim
2016-01-01
This article describes a two-day lesson in which fifth-grade students took on the role of marine biology scientists, using their critical-thinking and problem-solving skills to explore human impact on the blue crab ecosystem. The purpose of "Crabby Interactions" was to help students understand the impact of human activities on the local…
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Zembylas, Michalinos; Charalambous, Constadina; Charalambous, Panayiota
2016-01-01
This paper describes a qualitative study that explored the understandings of human rights, pedagogical perspectives and practices in human rights teaching of three Greek-Cypriot elementary teachers. The study revealed some significant challenges in human rights teaching that seemed to be common for all three participating teachers. First, all of…
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Surface Support Systems for Co-Operative and Integrated Human/Robotic Lunar Exploration
Mueller, Robert P.
2006-01-01
Human and robotic partnerships to realize space goals can enhance space missions and provide increases in human productivity while decreasing the hazards that the humans are exposed to. For lunar exploration, the harsh environment of the moon and the repetitive nature of the tasks involved with lunar outpost construction, maintenance and operation as well as production tasks associated with in-situ resource utilization, make it highly desirable to use robotic systems in co-operation with human activity. A human lunar outpost is functionally examined and concepts for selected human/robotic tasks are discussed in the context of a lunar outpost which will enable the presence of humans on the moon for extended periods of time.
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The Human Genome Project (HGP): dividends and challenges: a ...
African Journals Online (AJOL)
The Human Genome Project (HGP): dividends and challenges: a review. ... Genomic studies have given profound insights into the genetic organization of ... with it will be an essential part of modern medicine and biology for years to come.
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Gatlin, P. N.; Conover, H.; Berendes, T.; Maskey, M.; Naeger, A. R.; Wingo, S. M.
2017-12-01
A key component of NASA's Earth observation system is its field experiments, for intensive observation of particular weather phenomena, or for ground validation of satellite observations. These experiments collect data from a wide variety of airborne and ground-based instruments, on different spatial and temporal scales, often in unique formats. The field data are often used with high volume satellite observations that have very different spatial and temporal coverage. The challenges inherent in working with such diverse datasets make it difficult for scientists to rapidly collect and analyze the data for physical process studies and validation of satellite algorithms. The newly-funded VISAGE project will address these issues by combining and extending nascent efforts to provide on-line data fusion, exploration, analysis and delivery capabilities. A key building block is the Field Campaign Explorer (FCX), which allows users to examine data collected during field campaigns and simplifies data acquisition for event-based research. VISAGE will extend FCX's capabilities beyond interactive visualization and exploration of coincident datasets, to provide interrogation of data values and basic analyses such as ratios and differences between data fields. The project will also incorporate new, higher level fused and aggregated analysis products from the System for Integrating Multi-platform data to Build the Atmospheric column (SIMBA), which combines satellite and ground-based observations into a common gridded atmospheric column data product; and the Validation Network (VN), which compiles a nationwide database of coincident ground- and satellite-based radar measurements of precipitation for larger scale scientific analysis. The VISAGE proof-of-concept will target "golden cases" from Global Precipitation Measurement Ground Validation campaigns. This presentation will introduce the VISAGE project, initial accomplishments and near term plans.
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Assessing human rights impacts in corporate development projects
Energy Technology Data Exchange (ETDEWEB)
Salcito, Kendyl, E-mail: kendyl.salcito@unibas.ch [Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel (Switzerland); University of Basel, P.O. Box, CH-4003 Basel (Switzerland); NomoGaia, 1900 Wazee Street, Suite 303, Denver, CO 80202 (United States); NewFields, LLC, Denver, CO 80202 (United States); Utzinger, Jürg, E-mail: juerg.utzinger@unibas.ch [Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel (Switzerland); University of Basel, P.O. Box, CH-4003 Basel (Switzerland); Weiss, Mitchell G., E-mail: Mitchell-g.Weiss@unibas.ch [Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel (Switzerland); University of Basel, P.O. Box, CH-4003 Basel (Switzerland); Münch, Anna K., E-mail: annak.muench@gmail.com [Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610 (United States); Singer, Burton H., E-mail: bhsinger@epi.ufl.edu [Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610 (United States); Krieger, Gary R., E-mail: gkrieger@newfields.com [NewFields, LLC, Denver, CO 80202 (United States); Wielga, Mark, E-mail: wielga@nomogaia.org [NomoGaia, 1900 Wazee Street, Suite 303, Denver, CO 80202 (United States); NewFields, LLC, Denver, CO 80202 (United States)
2013-09-15
Human rights impact assessment (HRIA) is a process for systematically identifying, predicting and responding to the potential impact on human rights of a business operation, capital project, government policy or trade agreement. Traditionally, it has been conducted as a desktop exercise to predict the effects of trade agreements and government policies on individuals and communities. In line with a growing call for multinational corporations to ensure they do not violate human rights in their activities, HRIA is increasingly incorporated into the standard suite of corporate development project impact assessments. In this context, the policy world's non-structured, desk-based approaches to HRIA are insufficient. Although a number of corporations have commissioned and conducted HRIA, no broadly accepted and validated assessment tool is currently available. The lack of standardisation has complicated efforts to evaluate the effectiveness of HRIA as a risk mitigation tool, and has caused confusion in the corporate world regarding company duties. Hence, clarification is needed. The objectives of this paper are (i) to describe an HRIA methodology, (ii) to provide a rationale for its components and design, and (iii) to illustrate implementation of HRIA using the methodology in two selected corporate development projects—a uranium mine in Malawi and a tree farm in Tanzania. We found that as a prognostic tool, HRIA could examine potential positive and negative human rights impacts and provide effective recommendations for mitigation. However, longer-term monitoring revealed that recommendations were unevenly implemented, dependent on market conditions and personnel movements. This instability in the approach to human rights suggests a need for on-going monitoring and surveillance. -- Highlights: • We developed a novel methodology for corporate human rights impact assessment. • We piloted the methodology on two corporate projects—a mine and a plantation.
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Assessing human rights impacts in corporate development projects
International Nuclear Information System (INIS)
Salcito, Kendyl; Utzinger, Jürg; Weiss, Mitchell G.; Münch, Anna K.; Singer, Burton H.; Krieger, Gary R.; Wielga, Mark
2013-01-01
Human rights impact assessment (HRIA) is a process for systematically identifying, predicting and responding to the potential impact on human rights of a business operation, capital project, government policy or trade agreement. Traditionally, it has been conducted as a desktop exercise to predict the effects of trade agreements and government policies on individuals and communities. In line with a growing call for multinational corporations to ensure they do not violate human rights in their activities, HRIA is increasingly incorporated into the standard suite of corporate development project impact assessments. In this context, the policy world's non-structured, desk-based approaches to HRIA are insufficient. Although a number of corporations have commissioned and conducted HRIA, no broadly accepted and validated assessment tool is currently available. The lack of standardisation has complicated efforts to evaluate the effectiveness of HRIA as a risk mitigation tool, and has caused confusion in the corporate world regarding company duties. Hence, clarification is needed. The objectives of this paper are (i) to describe an HRIA methodology, (ii) to provide a rationale for its components and design, and (iii) to illustrate implementation of HRIA using the methodology in two selected corporate development projects—a uranium mine in Malawi and a tree farm in Tanzania. We found that as a prognostic tool, HRIA could examine potential positive and negative human rights impacts and provide effective recommendations for mitigation. However, longer-term monitoring revealed that recommendations were unevenly implemented, dependent on market conditions and personnel movements. This instability in the approach to human rights suggests a need for on-going monitoring and surveillance. -- Highlights: • We developed a novel methodology for corporate human rights impact assessment. • We piloted the methodology on two corporate projects—a mine and a plantation. • Human
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LHC project. Exploring the smallest world with the highest energy beam
International Nuclear Information System (INIS)
Kondo, Takahiko; Kobayashi, Tomio
2007-01-01
The LHC accelerator at CERN will be completed soon and the experiments are about to start, making it possible to explore the TeV energy region for the first time in human history. There exists a clear reason why the TeV region is especially important for experimental exploration. The Higgs particle, the last elusive element of the Standard Model, will be discovered with very high probability. In addition there are high chances to discover signs of new physics beyond the Standard Model such as SUSY particles. Dark matter may be discovered. As an introduction of the mini-special issue for LHC, its goals and history is briefly reviewed, followed by a description on LHC accelerator, four LHC experiments as well as the contributions by Japan. (author)
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Modular Power Standard for Space Explorations Missions
Oeftering, Richard C.; Gardner, Brent G.
2016-01-01
Future human space exploration will most likely be composed of assemblies of multiple modular spacecraft elements with interconnected electrical power systems. An electrical system composed of a standardized set modular building blocks provides significant development, integration, and operational cost advantages. The modular approach can also provide the flexibility to configure power systems to meet the mission needs. A primary goal of the Advanced Exploration Systems (AES) Modular Power System (AMPS) project is to establish a Modular Power Standard that is needed to realize these benefits. This paper is intended to give the space exploration community a "first look" at the evolving Modular Power Standard and invite their comments and technical contributions.
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Embracing Diversity: The Exploration of User Motivations in Citizen Science Astronomy Projects
Lee, Lo
2018-06-01
Online citizen science projects ask members of the public to donate spare time on their personal computers to process large datasets. A critical challenge for these projects is volunteer recruitment and retention. Many of these projects use Berkeley Open Infrastructure for Network Computing (BOINC), a piece of middleware, to support their operations. This poster analyzes volunteer motivations in two large, BOINC-based astronomy projects, Einstein@Home and Milkyway@Home. Volunteer opinions are addressed to assess whether and how competitive elements, such as credit and ranking systems, motivate volunteers. Findings from a study of project volunteers, comprising surveys (n=2,031) and follow-up interviews (n=21), show that altruism is the main incentive for participation because volunteers consider scientific research to be critical for humans. Multiple interviewees also revealed a passion for extrinsic motivations, i.e. those that involve recognition from other people, such as opportunities to become co-authors of publications or to earn financial benefits. Credit and ranking systems motivate nearly half of interviewees. By analyzing user motivations in astronomical BOINC projects, this research provides scientists with deeper understandings about volunteer communities and various types of volunteers. Building on these findings, scientists can develop different strategies, for example, awarding volunteers badges, to recruit and retain diverse volunteers, and thus enhance long-term user participation in astronomical BOINC projects.
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Exploration Laboratory Analysis FY13
Krihak, Michael; Perusek, Gail P.; Fung, Paul P.; Shaw, Tianna, L.
2013-01-01
The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability (ExMC) risk, which is stated as the Risk of Inability to Adequately Treat an Ill or Injured Crew Member, and ExMC Gap 4.05: Lack of minimally invasive in-flight laboratory capabilities with limited consumables required for diagnosing identified Exploration Medical Conditions. To mitigate this risk, the availability of inflight laboratory analysis instrumentation has been identified as an essential capability in future exploration missions. Mission architecture poses constraints on equipment and procedures that will be available to treat evidence-based medical conditions according to the Space Medicine Exploration Medical Conditions List (SMEMCL), and to perform human research studies on the International Space Station (ISS) that are supported by the Human Health and Countermeasures (HHC) element. Since there are significant similarities in the research and medical operational requirements, ELA hardware development has emerged as a joint effort between ExMC and HHC. In 2012, four significant accomplishments were achieved towards the development of exploration laboratory analysis for medical diagnostics. These achievements included (i) the development of high priority analytes for research and medical operations, (ii) the development of Level 1 functional requirements and concept of operations documentation, (iii) the selection and head-to-head competition of in-flight laboratory analysis instrumentation, and (iv) the phase one completion of the Small Business Innovation Research (SBIR) projects under the topic Smart Phone Driven Blood-Based Diagnostics. To utilize resources efficiently, the associated documentation and advanced technologies were integrated into a single ELA plan that encompasses ExMC and HHC development efforts. The requirements and high priority analytes was used in the selection of the four in-flight laboratory analysis performers. Based upon the
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Environmental effects of human exploration of the Moon
Mendell, Wendell
Aerospace engineers use the term Environment to designate a set of externally imposed bound-ary conditions under which a device must operate. Although the parameters may be time-varying, the engineer thinks of the operating environment as being fixed. Any effect the device might have on the environment generally is neglected. In the case where the device is intended to measure the environment, its effect on the measured quantities must be considered. For example, a magnetometer aboard a spacecraft must be extended on a boom to minimize the disturbing influence of the spacecraft on the magnetic field, particularly if the field is weak. In contrast, Environment has taken on political and even ethical connotations in modern Western society, referring to human-induced alterations to those aspects of the terrestrial environment that are required for a healthy and productive life. The so-called Green Movement takes preservation of the environment as its mantra. Scientists are at the center of the debate on environmental issues. However, the concern of scientists over irreversible consequences of hu-man activity extend beyond ecology to preservation of cultural artifacts and to effects that alter the ability to conduct investigations such as light pollution in astronomy. The policy of Planetary Protection applied to science and exploration missions to other bodies in the solar system arises from the concern for deleterious effects in terrestrial ecology from hypothetical extraterrestrial life forms as well as overprints of extraterrestrial environments by terrestrial biology. Some in the scientific community are advocating extension of the planetary protection concept beyond exobiology to include fragile planetary environments by might be permanently altered by human activity e.g., the lunar exosphere. Beyond the scientific community, some environmentalists argue against any changes to the Moon at all, including formation of new craters or the alteration of the natural
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Enhancing Biology Instruction with the Human Genome Project
Buxeda, Rosa J.; Moore-Russo, Deborah A.
2003-01-01
The Human Genome Project (HGP) is a recent scientific milestone that has received notable attention. This article shows how a biology course is using the HGP to enhance students' experiences by providing awareness of cutting edge research, with information on new emerging career options, and with opportunities to consider ethical questions raised…
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Caldwell Ranch Exploration and Confirmation Project, Northwest Geysers, CA
Energy Technology Data Exchange (ETDEWEB)
Walters, Mark A.
2013-04-25
The purpose of the Caldwell Ranch Exploration and Confirmation Project was to drill, test, and confirm the present economic viability of the undeveloped geothermal reservoir in the 870 acre Caldwell Ranch area of the Northwest Geysers that included the CCPA No.1 steam field. All of the drilling, logging, and sampling challenges were met. Three abandoned wells, Prati 5, Prati 14 and Prati 38 were re-opened and recompleted to nominal depths of 10,000 feet in 2010. Two of the wells required sidetracking. The flow tests indicated Prati 5 Sidetrack 1 (P-5 St1), Prati 14 (P-14) and Prati 38 Sidetrack 2 (P-38 St2) were collectively capable of initially producing an equivalent of 12 megawatts (MWe) of steam using a conversion rate of 19,000 pounds of steam/hour
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A human rights based approach to project induced displacement and resettlement
van der Ploeg, Lidewij; Vanclay, Frank
2017-01-01
AbstractRespecting, protecting and fulfilling human rights must become more prominent in both the processes and outcomes of resettlement. We have developed a Human Rights-Based Approach to Resettlement for use by project operators, rights holders and governments so that they can better understand
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A human rights based approach to project induced displacement and resettlement
van der Ploeg, Lidewij; Vanclay, Frank
2017-01-01
Respecting, protecting and fulfilling human rights must become more prominent in both the processes and outcomes of resettlement. We have developed a Human Rights-Based Approach to Resettlement for use by project operators, rights holders and governments so that they can better understand what the
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Guilherme, Elsa; Faria, Cláudia; Boaventura, Diana
2016-01-01
The purpose of the study was to investigate how young students engage in an inquiry-based project driven by real-life contexts. Elementary school children were engaged in a small inquiry project centred on marine biodiversity and species adaptations. All activities included the exploration of an out-of-school setting as a learning context. A total…
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The Human Genome Project and the social contract: a law policy approach.
Byk, C
1992-08-01
For the first time in history, genetics will enable science to completely identify each human as genetically unique. Will this knowledge reinforce the trend for more individual liberties or will it create a 'brave new world'? A law policy approach to the problems raised by the human genome project shows how far our democratic institutions are from being the proper forum to discuss such issues. Because of the fears and anxiety raised in the population, and also because of its wide implications on the everyday life, the human genome analysis more than any other project needs to succeed in setting up such a social assessment.
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The Human Genome Project: Biology, Computers, and Privacy.
Cutter, Mary Ann G.; Drexler, Edward; Gottesman, Kay S.; Goulding, Philip G.; McCullough, Laurence B.; McInerney, Joseph D.; Micikas, Lynda B.; Mural, Richard J.; Murray, Jeffrey C.; Zola, John
This module, for high school teachers, is the second of two modules about the Human Genome Project (HGP) produced by the Biological Sciences Curriculum Study (BSCS). The first section of this module provides background information for teachers about the structure and objectives of the HGP, aspects of the science and technology that underlie the…
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Low-Latency Teleoperations for Human Exploration and Evolvable Mars Campaign
Lupisella, Mark; Wright, Michael; Arney, Dale; Gershman, Bob; Stillwagen, Fred; Bobskill, Marianne; Johnson, James; Shyface, Hilary; Larman, Kevin; Lewis, Ruthan;
2015-01-01
NASA has been analyzing a number of mission concepts and activities that involve low-latency telerobotic (LLT) operations. One mission concept that will be covered in this presentation is Crew-Assisted Sample Return which involves the crew acquiring samples (1) that have already been delivered to space, and or acquiring samples via LLT from orbit to a planetary surface and then launching the samples to space to be captured in space and then returned to the earth with the crew. Both versions of have key roles for low-latency teleoperations. More broadly, the NASA Evolvable Mars Campaign is exploring a number of other activities that involve LLT, such as: (a) human asteroid missions, (b) PhobosDeimos missions, (c) Mars human landing site reconnaissance and site preparation, and (d) Mars sample handling and analysis. Many of these activities could be conducted from Mars orbit and also with the crew on the Mars surface remotely operating assets elsewhere on the surface, e.g. for exploring Mars special regions and or teleoperating a sample analysis laboratory both of which may help address planetary protection concerns. The operational and technology implications of low-latency teleoperations will be explored, including discussion of relevant items in the NASA Technology Roadmap and also how previously deployed robotic assets from any source could subsequently be used by astronauts via LLT.
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Human haptic perception is interrupted by explorative stops of milliseconds
Directory of Open Access Journals (Sweden)
Martin eGrunwald
2014-04-01
Full Text Available Introduction: The explorative scanning movements of the hands have been compared to those of the eyes. The visual process is known to be composed of alternating phases of saccadic eye movements and fixation pauses. Descriptive results suggest that during the haptic exploration of objects short movement pauses occur as well. The goal of the present study was to detect these explorative stops (ES during one-handed and two-handed haptic explorations of various objects and patterns, and to measure their duration. Additionally, the associations between the following variables were analyzed: a between mean exploration time and duration of ES, b between certain stimulus features and ES frequency, and c the duration of ES during the course of exploration. Methods: Five different experiments were used. The first two experiments were classical recognition tasks of unknown haptic stimuli (A and of common objects (B. In experiment C space-position information of angle legs had to be perceived and reproduced. For experiments D and E the PHANToM haptic device was used for the exploration of virtual (D and real (E sunken reliefs. Results: In each experiment we observed explorative stops of different average durations. For experiment A: 329.50 ms, experiment B: 67.47 ms, experiment C: 189.92 ms, experiment D: 186.17 ms and experiment E: 140.02 ms. Significant correlations were observed between exploration time and the duration of the ES. Also, ES occurred more frequently, but not exclusively, at defined stimulus features like corners, curves and the endpoints of lines. However, explorative stops do not occur every time a stimulus feature is explored. Conclusions: We assume that ES are a general aspect of human haptic exploration processes. We have tried to interpret the occurrence and duration of ES with respect to the Hypotheses-Rebuild-Model and the Limited Capacity Control System theory.
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Holden, Kristina L.; Sandor, Aniko; Thompson, Shelby G.; Kaiser, Mary K.; McCann, Robert S.; Begault, D. R.; Adelstein, B. D.; Beutter, B. R.; Wenzel, E. M.; Godfroy, M.;
2010-01-01
The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers atJohnson Space Center and Ames Research Center. T
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Hay, Jason; Mullins, Carie; Graham, Rachael; Williams-Byrd, Julie; Reeves, John D.
2011-01-01
Human spaceflight organizations have ambitious goals for expanding human presence throughout the solar system. To meet these goals, spaceflight organizations have to overcome complex technical challenges for human missions to Mars, Near Earth Asteroids, and other distant celestial bodies. Resolving these challenges requires considerable resources and technological innovations, such as advancements in human health and countermeasures for space environments; self-sustaining habitats; advanced power and propulsion systems; and information technologies. Today, government space agencies seek cooperative endeavors to reduce cost burdens, improve human exploration capabilities, and foster knowledge sharing among human spaceflight organizations. This paper looks at potential opportunities for partnerships and spin-ins from economic sectors outside the space industry. It highlights innovative technologies and breakthrough concepts that could have significant impacts on space exploration and identifies organizations throughout the broader economy that specialize in these technologies.
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Miller, Thomas
2007-01-01
The NASA Glenn Research Center (GRC), along with the Goddard Space Flight Center (GSFC), Jet Propulsion Laboratory (JPL), Johnson Space Center (JSC), Marshall Space Flight Center (MSFC), and industry partners, is leading a space-rated lithium-ion advanced development battery effort to support the vision for Exploration. This effort addresses the lithium-ion battery portion of the Energy Storage Project under the Exploration Technology Development Program. Key discussions focus on the lithium-ion cell component development activities, a common lithium-ion battery module, test and demonstration of charge/discharge cycle life performance and safety characterization. A review of the space-rated lithium-ion battery project will be presented highlighting the technical accomplishments during the past year.
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National Aeronautics and Space Administration — The Digital Astronaut Simulator (DAS) is a low Technology Readiness Level (TRL) NASA project with promising benefits to Human Health Countermeasures. In providing...
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Simulation technology used for risky assessment in deep exploration project in China
jiao, J.; Huang, D.; Liu, J.
2013-12-01
Deep exploration has been carried out in China for five years in which various heavy duty instruments and equipments are employed for gravity, magnetic, seismic and electromagnetic data prospecting as well as ultra deep drilling rig established for obtaining deep samples, and so on. The deep exploration is a large and complex system engineering crossing multiple subjects with great investment. It is necessary to employ advanced technical means technology for verification, appraisal, and optimization of geographical prospecting equipment development. To reduce risk of the application and exploration, efficient and allegeable management concept and skills have to be enhanced in order to consolidate management measure and workflow to benefit the ambitious project. Therefore, evidence, prediction, evaluation and related decision strategies have to be taken into accouter simultaneously to meet practical scientific requests and technique limits and extendable attempts. Simulation technique is then proposed as a tool that can be used to carry out dynamic test on actual or imagined system. In practice, it is necessary to combine the simulation technique with the instruments and equipment to accomplish R&D tasks. In this paper, simulation technique is introduced into the R&D process of heavy-duty equipment and high-end engineering project technology. Based on the information provided by a drilling group recently, a digital model is constructed by combination of geographical data, 3d visualization, database management, and visual reality technologies together. It result in push ahead a R&D strategy, in which data processing , instrument application, expected result and uncertainty, and even operation workflow effect environment atmosphere are simulated systematically or simultaneously, in order to obtain an optimal consequence as well as equipment updating strategy. The simulation technology is able to adjust, verify, appraise and optimize the primary plan due to changing in
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Exploration Life Support Technology Development for Lunar Missions
Ewert, Michael K.; Barta, Daniel J.; McQuillan, Jeffrey
2009-01-01
Exploration Life Support (ELS) is one of NASA's Exploration Technology Development Projects. ELS plans, coordinates and implements the development of new life support technologies for human exploration missions as outlined in NASA's Vision for Space Exploration. ELS technology development currently supports three major projects of the Constellation Program - the Orion Crew Exploration Vehicle (CEV), the Altair Lunar Lander and Lunar Surface Systems. ELS content includes Air Revitalization Systems (ARS), Water Recovery Systems (WRS), Waste Management Systems (WMS), Habitation Engineering, Systems Integration, Modeling and Analysis (SIMA), and Validation and Testing. The primary goal of the ELS project is to provide different technology options to Constellation which fill gaps or provide substantial improvements over the state-of-the-art in life support systems. Since the Constellation missions are so challenging, mass, power, and volume must be reduced from Space Shuttle and Space Station technologies. Systems engineering analysis also optimizes the overall architecture by considering all interfaces with the life support system and potential for reduction or reuse of resources. For long duration missions, technologies which aid in closure of air and water loops with increased reliability are essential as well as techniques to minimize or deal with waste. The ELS project utilizes in-house efforts at five NASA centers, aerospace industry contracts, Small Business Innovative Research contracts and other means to develop advanced life support technologies. Testing, analysis and reduced gravity flight experiments are also conducted at the NASA field centers. This paper gives a current status of technologies under development by ELS and relates them to the Constellation customers who will eventually use them.
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NASA UAS Integration into the NAS Project: Human Systems Integration
Shively, Jay
2016-01-01
This presentation provides an overview of the work the Human Systems Integration (HSI) sub-project has done on detect and avoid (DAA) displays while working on the UAS (Unmanned Aircraft System) Integration into the NAS project. The most recent simulation on DAA interoperability with Traffic Collision Avoidance System (TCAS) is discussed in the most detail. The relationship of the work to the larger UAS community and next steps are also detailed.
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Transition in the Human Exploration of Space at NASA
Koch, Carla A.; Cabana, Robert
2011-01-01
NASA is taking the next step in human exploration, beyond low Earth orbit. We have been going to low Earth orbit for the past 50 years and are using this experience to work with commercial companies to perform this function. This will free NASA resources to develop the systems necessary to travel to a Near Earth Asteroid, the Moon, Lagrange Points, and eventually Mars. At KSC, we are positioning ourselves to become a multi-user launch complex and everything we are working on is bringing us closer to achieving this goal. A vibrant multi-use spaceport is to the 21st Century what the airport was to the 20th Century - an invaluable transportation hub that supports government needs while promoting economic development and commercial markets beyond Earth's atmosphere. This past year saw the end of Shuttle, but the announcements of NASA's crew module, Orion, and heavy-lift rocket, the SLS, as well as the establishment of the Commercial Crew Program. We have a busy, but very bright future ahead of us and KSC is looking forward to playing an integral part in the next era of human space exploration. The future is SLS, 21st Century Ground Systems Program, and the Commercial Crew Program; and the future is here.
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Overview of an Integrated Medical System for Exploration Missions
Watkins, Sharmila; Rubin, David
2013-01-01
The Exploration Medical Capability (ExMC) element of the NASA Human Research Program (HRP) is charged with addressing the risk of unacceptable health and mission outcomes due to limitations of inflight medical capabilities. The Exploration Medical System Demonstration (EMSD) is a project within the ExMC element aimed at reducing this risk by improving the medical capabilities available for exploration missions. The EMSD project will demonstrate, on the ground and on ISS, the integration of several components felt to be essential to the delivery of medical care during long ]duration missions outside of low Earth orbit. The components of the EMSD include the electronic medical record, assisted medical procedure software, medical consumables tracking technology and RFID ] tagged consumables, video conferencing capability, ultrasound device and probes (ground demonstration only), peripheral biosensors, and the software to allow communication among the various components (middleware). This presentation seeks to inform our international partners of the goals and objectives of the EMSD and to foster collaboration opportunities related to this and future projects.
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DEFF Research Database (Denmark)
Assaf, Yaniv; Alexander, Daniel C; Jones, Derek K
2013-01-01
Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper...... summarizes the project and describes the perspective of using micro-structural measures to study the connectome.......In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using...
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Energy Technology Data Exchange (ETDEWEB)
Nichols, E.K.
2000-02-17
Advances in the biomedical sciences, especially in human genomics, will dramatically influence law, medicine, public health, and many other sectors of our society in the decades ahead. The public already senses the revolutionary nature of genomic knowledge. In the US and Europe, we have seen widespread discussions about genetic discrimination in health insurance; privacy issues raised by the proliferation of DNA data banks; the challenge of interpreting new DNA diagnostic tests; changing definitions of what it means to be healthy; and the science and ethics of cloning animals and human beings. The primary goal of the Whitehead/ASLME Policy Symposium was to provide a bridge between the research community and professionals, who were just beginning to grasp the potential impact of new genetic technologies on their fields. The ''Human Genome Project: Science, Law, and Social Change in the 21st Century'' initially was designed as a forum for 300-500 physicians, lawyers, consumers, ethicists, and scientists to explore the impact of new genetic technologies and prepare for the challenges ahead.
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Medical and technology requirements for human solar system exploration missions
Nicogossian, Arnauld; Harris, Leonard; Couch, Lana; Sulzman, Frank; Gaiser, Karen
1989-01-01
Measures that need to be taken to cope with the health problems posed by zero gravity and radiation in manned solar system exploration missions are discussed. The particular systems that will be used aboard Space Station Freedom are addressed, and relevant human factors problems are examined. The development of a controlled ecological life support system is addressed.
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ALASKA OIL AND GAS EXPLORATION, DEVELOPMENT, AND PERMITTING PROJECT
Energy Technology Data Exchange (ETDEWEB)
Richard McMahon; Robert Crandall; Chas Dense; Sean Weems
2003-11-19
This is the second technical report, covering the period from April 1, 2003 through September 30, 2003. This project brings together three parts of the oil exploration, development, and permitting process to form the foundation for a more fully integrated information technology infrastructure for the State of Alaska. The geo-technical component is a shared effort between the State Department of Administration and the US Department of Energy. The Alaska Oil and Gas Conservation Commission is rapidly converting high volumes of paper documents and geo-technical information to formats suitable for search and retrieval over the Internet. The permitting component is under the lead of the DNR Office of Project Management and Permitting. A web-based system will enable the public and other review participants to track permit status, submit and view comments, and obtain important project information on-line. By automating several functions of the current manual process, permit applications will be completed more quickly and accurately, and agencies will be able to complete reviews with fewer delays. Structural changes are taking place in terms of organization, statutory authority, and regulatory requirements. Geographic Information Systems are a central component to the organization of information, and the delivery of on-line services. Progress has been made to deploy the foundation system for the shared GIS based on open GIS protocols to the extent feasible. Alaska has nearly one-quarter of the nation's supply of crude oil, at least five billion barrels of proven reserves. The American Association of Petroleum Geologists report that the 1995 National Assessment identified the North Slope as having 7.4 billion barrels of technically recoverable oil and over 63 trillion cubic feet of natural gas. From these reserves, Alaska produces roughly one-fifth of the nation's daily crude oil production, or approximately one million barrels per day from over 1,800 active wells.
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Human Genome Teacher Networking Project, Final Report, April 1, 1992 - March 31, 1998
Energy Technology Data Exchange (ETDEWEB)
Collins, Debra
1999-10-01
Project to provide education regarding ethical legal and social implications of Human Genome Project to high school science teachers through two consecutive summer workshops, in class activities, and peer teaching workshops.
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Cosmic Humanity: Utopia, Realities, Prospects
Sergey Krichevsky
2017-01-01
The philosophical foundations of the theory and practice of the creation of cosmic humanity as a process of the evolution of human civilization, the emergence into space, with the prospect of resettlement outside the Earth are considered. There is a connection between myths, fantasies, ideas, concepts and projects aimed at the exploration of outer space, the creation of cosmic humanity. A new and voluminous definition of cosmic humanity in the evolutionary paradigm is given. Cosmic humanity i...
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The Human Genome Project: applications in the diagnosis and treatment of neurologic disease.
Evans, G A
1998-10-01
The Human Genome Project (HGP), an international program to decode the entire DNA sequence of the human genome in 15 years, represents the largest biological experiment ever conducted. This set of information will contain the blueprint for the construction and operation of a human being. While the primary driving force behind the genome project is the potential to vastly expand the amount of genetic information available for biomedical research, the ramifications for other fields of study in biological research, the biotechnology and pharmaceutical industry, our understanding of evolution, effects on agriculture, and implications for bioethics are likely to be profound.
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Hyatt, Mark J.; Straka, Sharon A.
2010-01-01
A return to the Moon to extend human presence, pursue scientific activities, use the Moon to prepare for future human missions to Mars, and expand Earth?s economic sphere, will require investment in developing new technologies and capabilities to achieve affordable and sustainable human exploration. From the operational experience gained and lessons learned during the Apollo missions, conducting long-term operations in the lunar environment will be a particular challenge, given the difficulties presented by the unique physical properties and other characteristics of lunar regolith, including dust. The Apollo missions and other lunar explorations have identified significant lunar dust-related problems that will challenge future mission success. Comprised of regolith particles ranging in size from tens of nanometers to microns, lunar dust is a manifestation of the complex interaction of the lunar soil with multiple mechanical, electrical, and gravitational effects. The environmental and anthropogenic factors effecting the perturbation, transport, and deposition of lunar dust must be studied in order to mitigate it?s potentially harmful effects on exploration systems and human explorers. The Dust Management Project (DMP) is tasked with the evaluation of lunar dust effects, assessment of the resulting risks, and development of mitigation and management strategies and technologies related to Exploration Systems architectures. To this end, the DMP supports the overall goal of the Exploration Technology Development Program (ETDP) of addressing the relevant high priority technology needs of multiple elements within the Constellation Program (CxP) and sister ETDP projects. Project scope, plans, and accomplishments will be presented.
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Analysis of the speckle properties in a laser projection system based on a human eye model.
Cui, Zhe; Wang, Anting; Ma, Qianli; Ming, Hai
2014-03-01
In this paper, the properties of the speckle that is observed by humans in laser projection systems are theoretically analyzed. The speckle pattern on the fovea of the human retina is numerically simulated by introducing a chromatic human eye model. The results show that the speckle contrast experienced by humans is affected by the light intensity of the projected images and the wavelength of the laser source when considering the paracentral vision. Furthermore, the image quality is also affected by these two parameters. We believe that these results are useful for evaluating the speckle noise in laser projection systems.
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Thronson, Harley; Carberry, Chris; Cassady, R. J.; Cooke, Doug; Hopkins, Joshua; Perino, Maria A.; Kirkpatrick, Jim; Raftery, Michael; Westenberg, Artemis; Zucker, Richard
2013-01-01
There is a growing consensus that within two decades initial human missions to Mars are affordable under plausible budget assumptions and with sustained international participation. In response to this idea, a distinguished group of experts from the Mars exploration stakeholder communities attended the "Affording Mars" workshop at George Washington University in December, 2013. Participants reviewed and discussed scenarios for affordable and sustainable human and robotic exploration of Mars, the role of the International Space Station over the coming decade as the essential early step toward humans to Mars, possible "bridge" missions in the 2020s, key capabilities required for affordable initial missions, international partnerships, and a usable definition of affordability and sustainability. We report here the findings, observations, and recommendations that were agreed to at that workshop.
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The 2001 activities and the 3rd workshop of the human resources development project in FNCA
International Nuclear Information System (INIS)
2002-07-01
In 1999, the Project for Human Resources Development (HRD) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project are two kinds of activity; In-workshop activity and Outside-of-workshop activity. The 3rd Workshop on Human Resources Development in the Nuclear Field was held on October 29 to November 1, at the Nuclear Training Center of KAERI. Participating countries were China, Indonesia, Republic of Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. The secretariat for the Human Resources Development Project is provided by the Nuclear Training Center of the Korea Atomic Energy Research Institute and the Nuclear Technology and Education Center of the Japan Atomic Energy Research Institute. This report consists of presentation papers and materials at the Workshop as In-Workshop Activity, a document of project review on Human Resources Development for the fourth Coordinators Meeting of FNCA at Tokyo on March, 2002, a letter of proposal from the Project Leader of Japan to the project leaders of the participating countries, and training materials of participating countries as Outside-Workshop Activity. (author)
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EDF EPR project: operating principles validation and human factor engineering program
International Nuclear Information System (INIS)
Lefebvre, B.; Berard, E.; Arpino, J.-M.
2005-01-01
This article describes the specificities of the operating principles chosen by EDF for the EPR project as a result of an extensive Human Factor Engineering program successfully implemented in an industrial project context. The design process and its achievements benefit of the EDF experience feedback not only in term of NPP operation - including the fully computerized control room of the N4-serie - but also in term of NPP designer. The elements exposed hereafter correspond to the basic design phase of EPR HMI which has been completed and successfully validated by the end of 2003. The article aims to remind the context of the project which basically consists in designing a modern and efficient HMI taking into account the operating needs while relying on proven and reliable technologies. The Human Factor Engineering program implemented merges these both aspects by : 1) being fully integrated within the project activities and scheduling; 2) efficiently taking into account the users needs as well as the feasibility constraints by relying on a multidisciplinary design team including HF specialists, I and C specialists, Process specialists and experienced operator representatives. The resulting design process makes a wide use of experience feedback and experienced operator knowledge to complete largely the existing standards for providing a fully useable and successful design method in an industrial context. The article underlines the design process highlights that largely contribute to the successful implementation of a Human Factor Engineering program for EPR. (authors)
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Columbia County Habitat for Humanity Passive Townhomes
Energy Technology Data Exchange (ETDEWEB)
None, None
2016-03-01
Columbia County Habitat for Humanity (CCHH) (New York, Climate Zone 5A) built a pair of townhomes to Passive House Institute U.S. (PHIUS+ 2015) criteria to explore approaches for achieving Passive House performance (specifically with respect to exterior wall, space-conditioning, and ventilation strategies) within the labor and budget context inherent in a Habitat for Humanity project. CCHH’s goal is to eventually develop a cost-justified Passive House prototype design for future projects.
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Life sciences space biology project planning
Primeaux, G.; Newkirk, K.; Miller, L.; Lewis, G.; Michaud, R.
1988-01-01
The Life Sciences Space Biology (LSSB) research will explore the effect of microgravity on humans, including the physiological, clinical, and sociological implications of space flight and the readaptations upon return to earth. Physiological anomalies from past U.S. space flights will be used in planning the LSSB project.The planning effort integrates science and engineering. Other goals of the LSSB project include the provision of macroscopic view of the earth's biosphere, and the development of spinoff technology for application on earth.
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Snoddy, Jimmy R.; Dumbacher, Daniel L.; Cook, Stephen A.
2006-01-01
The U.S. Vision for Space Exploration (January 2004) serves as the foundation for the National Aeronautics and Space Administration's (NASA) strategic goals and objectives. As the NASA Administrator outlined during his confirmation hearing in April 2005, these include: 1) Flying the Space Shuttle as safely as possible until its retirement, not later than 2010. 2) Bringing a new Crew Exploration Vehicle (CEV) into service as soon as possible after Shuttle retirement. 3) Developing a balanced overall program of science, exploration, and aeronautics at NASA, consistent with the redirection of the human space flight program to focus on exploration. 4) Completing the International Space Station (ISS) in a manner consistent with international partner commitments and the needs of human exploration. 5) Encouraging the pursuit of appropriate partnerships with the emerging commercial space sector. 6) Establishing a lunar return program having the maximum possible utility for later missions to Mars and other destinations. In spring 2005, the Agency commissioned a team of aerospace subject matter experts to perform the Exploration Systems Architecture Study (ESAS). The ESAS team performed in-depth evaluations of a number of space transportation architectures and provided recommendations based on their findings? The ESAS analysis focused on a human-rated Crew Launch Vehicle (CLV) for astronaut transport and a heavy lift Cargo Launch Vehicle (CaLV) to carry equipment, materials, and supplies for lunar missions and, later, the first human journeys to Mars. After several months of intense study utilizing safety and reliability, technical performance, budget, and schedule figures of merit in relation to design reference missions, the ESAS design options were unveiled in summer 2005. As part of NASA's systems engineering approach, these point of departure architectures have been refined through trade studies during the ongoing design phase leading to the development phase that
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Energy Storage: Batteries and Fuel Cells for Exploration
Manzo, Michelle A.; Miller, Thomas B.; Hoberecht, Mark A.; Baumann, Eric D.
2007-01-01
NASA's Vision for Exploration requires safe, human-rated, energy storage technologies with high energy density, high specific energy and the ability to perform in a variety of unique environments. The Exploration Technology Development Program is currently supporting the development of battery and fuel cell systems that address these critical technology areas. Specific technology efforts that advance these systems and optimize their operation in various space environments are addressed in this overview of the Energy Storage Technology Development Project. These technologies will support a new generation of more affordable, more reliable, and more effective space systems.
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National Aeronautics and Space Administration — PROBLEM, DEEP SPACE HUMAN EXPLORATION IS UNAFFORDABLE: In 2014 the NASA Advisory Council issued a finding that “The mismatch between NASA’s aspirations for human...
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The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data
Kohler, S.; Doelken, S.C.; Mungall, C.J.; Bauer, S.; Firth, H.V.; Bailleul-Forestier, I.; Black, G.C.M.; Brown, D.L.; Brudno, M.; Campbell, J.; FitzPatrick, D.R.; Eppig, J.T.; Jackson, A.P.; Freson, K.; Girdea, M.; Helbig, I.; Hurst, J.A.; Jahn, J.; Jackson, L.G.; Kelly, A.M.; Ledbetter, D.H.; Mansour, S.; Martin, C.L.; Moss, C.; Mumford, A.; Ouwehand, W.H.; Park, S.M.; Riggs, E.R.; Scott, R.H.; Sisodiya, S.; Vooren, S. van der; Wapner, R.J.; Wilkie, A.O.; Wright, C.F.; Silfhout, A.T. van; Leeuw, N. de; Vries, B. de; Washingthon, N.L.; Smith, C.L.; Westerfield, M.; Schofield, P.; Ruef, B.J.; Gkoutos, G.V.; Haendel, M.; Smedley, D.; Lewis, S.E.; Robinson, P.N.
2014-01-01
The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations between the HPO classes. In addition we have
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Exploring Human Activity Patterns Using Taxicab Static Points
Directory of Open Access Journals (Sweden)
Bin Jiang
2012-06-01
Full Text Available This paper explores the patterns of human activities within a geographical space by adopting the taxicab static points which refer to the locations with zero speed along the tracking trajectory. We report the findings from both aggregated and individual aspects. Results from the aggregated level indicate the following: (1 Human activities exhibit an obvious regularity in time, for example, there is a burst of activity during weekend nights and a lull during the week. (2 They show a remarkable spatial drifting pattern, which strengthens our understanding of the activities in any given place. (3 Activities are heterogeneous in space irrespective of their drifting with time. These aggregated results not only help in city planning, but also facilitate traffic control and management. On the other hand, investigations on an individual level suggest that (4 activities witnessed by one taxicab will have different temporal regularity to another, and (5 each regularity implies a high level of prediction with low entropy by applying the Lempel-Ziv algorithm.
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Human projected area factors for detailed direct and diffuse solar radiation analysis
DEFF Research Database (Denmark)
Kubaha, K.; Fiala, D.; Toftum, Jørn
2004-01-01
Projected area factors for individual segments of the standing and sedentary human body were modelled for both direct and diffuse solar radiation using detailed 3D geometry and radiation models. The local projected area factors with respect to direct short-wave radiation are a function of the solar...
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77 FR 5489 - Identification of Human Cell Lines Project
2012-02-03
... individual or species. With the advent of standardized, simple, and rapid methods for human cell line... project will undergo STR profiling, a DNA profiling method that examines/screens for STRs (DNA elements 2... distinct DNA profile and when the STR DNA fragment sizes are converted to numeric values, the DNA profiles...
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Landscaping Habitat for Humanity Homes: A Community Outreach Project
Ramsay, Jodie L.
2008-01-01
The purpose of this project is to incorporate a community service component into a Biology course at Northern State University (NSU) in Aberdeen, SD. Students in an upper-level botany course (Plant Structure and Function) provide landscaping services to homeowners who have purchased homes through Habitat for Humanity. Homeowner satisfaction with…
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Exploring the role of instant messaging in a global software development project
DEFF Research Database (Denmark)
Dittrich, Y.; Giuffrida, Rosalba
2011-01-01
Communication plays a vital role in software devel- opment projects. Globally distributed teams use a mix of dif- ferent communication channels to get the work done. In this paper, we report on an empirical study of a team distributed across Denmark and India. This paper explores the integration...... documentation. Our analysis provides an indication that IM can play a special role in such socio-technical communication systems: IM acts as a real time glue between different chan- nels. The communication through IM also provides a means to build trust and social relationships with co-workers....
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The mouse-human anatomy ontology mapping project.
Hayamizu, Terry F; de Coronado, Sherri; Fragoso, Gilberto; Sioutos, Nicholas; Kadin, James A; Ringwald, Martin
2012-01-01
The overall objective of the Mouse-Human Anatomy Project (MHAP) was to facilitate the mapping and harmonization of anatomical terms used for mouse and human models by Mouse Genome Informatics (MGI) and the National Cancer Institute (NCI). The anatomy resources designated for this study were the Adult Mouse Anatomy (MA) ontology and the set of anatomy concepts contained in the NCI Thesaurus (NCIt). Several methods and software tools were identified and evaluated, then used to conduct an in-depth comparative analysis of the anatomy ontologies. Matches between mouse and human anatomy terms were determined and validated, resulting in a highly curated set of mappings between the two ontologies that has been used by other resources. These mappings will enable linking of data from mouse and human. As the anatomy ontologies have been expanded and refined, the mappings have been updated accordingly. Insights are presented into the overall process of comparing and mapping between ontologies, which may prove useful for further comparative analyses and ontology mapping efforts, especially those involving anatomy ontologies. Finally, issues concerning further development of the ontologies, updates to the mapping files, and possible additional applications and significance were considered. DATABASE URL: http://obofoundry.org/cgi-bin/detail.cgi?id=ma2ncit.
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Yuk Chan, Cecilia Ka
2012-08-01
Experiential learning pedagogy is taking a lead in the development of graduate attributes and educational aims as these are of prime importance for society. This paper shows a community service experiential project conducted in China. The project enabled students to serve the affected community in a post-earthquake area by applying their knowledge and skills. This paper documented the students' learning process from their project goals, pre-trip preparations, work progress, obstacles encountered to the final results and reflections. Using the data gathered from a focus group interview approach, the four components of Kolb's learning cycle, the concrete experience, reflection observation, abstract conceptualisation and active experimentation, have been shown to transform and internalise student's learning experience, achieving a variety of learning outcomes. The author will also explore how this community service type of experiential learning in the engineering discipline allowed students to experience deep learning and develop their graduate attributes.
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Eaton, Lisa A.; Kalichman, Seth C.; Kenny, David A.; Harel, Ofer
2013-01-01
Background Project EXPLORE -- a large-scale, behavioral intervention tested among men who have sex with men (MSM) at-risk for HIV infection --was generally deemed as ineffective in reducing HIV incidence. Using novel and more precise data analytic techniques we reanalyzed Project EXPLORE by including both direct and indirect paths of intervention effects. Methods Data from 4,296 HIV negative MSM who participated in Project EXPLORE, which included ten sessions of behavioral risk reduction counseling completed from 1999-2005, were included in the analysis. We reanalyzed the data to include parameters that estimate the overtime effects of the intervention on unprotected anal sex and the over-time effects of the intervention on HIV status mediated by unprotected anal sex simultaneously in a single model. Results We found the indirect effect of intervention on HIV infection through unprotected anal sex to be statistically significant up through 12 months post-intervention, OR=.83, 95% CI=.72-.95. Furthermore, the intervention significantly reduced unprotected anal sex up through 18 months post-intervention, OR=.79, 95% CI=.63-.99. Discussion Our results reveal effects not tested in the original model that offer new insight into the effectiveness of a behavioral intervention for reducing HIV incidence. Project EXPLORE demonstrated that when tested against an evidence-based, effective control condition can result in reductions in rates of HIV acquisition at one year follow-up. Findings highlight the critical role of addressing behavioral risk reduction counseling in HIV prevention. PMID:23245226
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Humane Orientation as a New Cultural Dimension of the GLOBE Project
DEFF Research Database (Denmark)
Schlösser, Oliver; Frese, Michael; Heintze, Anna-Maria
2013-01-01
We validate, extend, and empirically and theoretically criticize the cultural dimension of humane orientation of the project GLOBE (Global Leadership and Organizational Behavior Effectiveness Research Program). Theoretically, humane orientation is not just a one-dimensionally positive concept about...... study used student samples from 25 countries that were either high or low in humane orientation (N = 876) and studied their relation to the traditional GLOBE scale and other cultural-level measures (agreeableness, religiosity, authoritarianism, and welfare state score). Findings revealed a strong...... correlation between humane orientation and agreeableness, welfare state score, and religiosity. Out-group humane orientation proved to be the more relevant subfacet of the original humane orientation construct, suggesting that future research on humane orientation should make use of this measure instead...
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Mango, Edward J.
2016-01-01
NASA and its industry and international partners are embarking on a bold and inspiring development effort to design and build an exploration class space system. The space system is made up of the Orion system, the Space Launch System (SLS) and the Ground Systems Development and Operations (GSDO) system. All are highly coupled together and dependent on each other for the combined safety of the space system. A key area of system safety focus needs to be in the ground and flight application software system (GFAS). In the development, certification and operations of GFAS, there are a series of safety characteristics that define the approach to ensure mission success. This paper will explore and examine the safety characteristics of the GFAS development. The GFAS system integrates the flight software packages of the Orion and SLS with the ground systems and launch countdown sequencers through the 'agile' software development process. A unique approach is needed to develop the GFAS project capabilities within this agile process. NASA has defined the software development process through a set of standards. The standards were written during the infancy of the so-called industry 'agile development' movement and must be tailored to adapt to the highly integrated environment of human exploration systems. Safety of the space systems and the eventual crew on board is paramount during the preparation of the exploration flight systems. A series of software safety characteristics have been incorporated into the development and certification efforts to ensure readiness for use and compatibility with the space systems. Three underlining factors in the exploration architecture require the GFAS system to be unique in its approach to ensure safety for the space systems, both the flight as well as the ground systems. The first are the missions themselves, which are exploration in nature, and go far beyond the comfort of low Earth orbit operations. The second is the current exploration
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du Preez, Petro; Becker, Anne
2016-01-01
In light of growing critique of human rights and human rights education, this article explores ontologies of human rights, the possibilities they present for dissensus and how this could influence human rights education in post-conflict education contexts towards reconciliation. We draw on Dembour's (2010) categorisation of the different schools…
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Abell, Paul; Mazanek, Dan; Barbee, Brent; Landis, Rob; Johnson, Lindley; Yeomans, Don; Reeves, David; Drake, Bret; Friedensen, Victoria
2013-01-01
Over the past several years, much attention has been focused on the human exploration of near-Earth asteroids (NEAs). Two independent NASA studies examined the feasibility of sending piloted missions to NEAs, and in 2009, the Augustine Commission identified NEAs as high profile destinations for human exploration missions beyond the Earth- Moon system as part of the Flexible Path. More recently the current U.S. presidential administration directed NASA to include NEAs as destinations for future human exploration with the goal of sending astronauts to a NEA in the mid to late 2020s. This directive became part of the official National Space Policy of the United States of America as of June 28, 2010. The scientific and hazard mitigation benefits, along with the programmatic and operational benefits of a human venture beyond the Earth-Moon system, make a mission to a NEA using NASA s proposed exploration systems a compelling endeavor.
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Project and implementation of the human/system interface laboratory
International Nuclear Information System (INIS)
Carvalho, Paulo Victor R. de; Obadia, Isaac Jose; Vidal, Mario Cesar Rodriguez
2002-01-01
Analog instrumentation is being increasingly replaced by digital technology in new nuclear power plants, such as Angra III, as well as in existing operating plants, such as Angra I and II, for modernization and life-extension projects. In this new technological environment human factors issues aims to minimize failures in nuclear power plants operation due to human error. It is well known that 30% to 50% of the detected unforeseen problems involve human errors. Presently, human factors issues must be considered during the development of advanced human-system interfaces for the plant. IAEA has considered the importance of those issues and has published TECDOC's and Safety Series Issues on the matter. Thus, there is a need to develop methods and criteria to asses, compare, optimize and validate the human-system interface associated with totally new or hybrid control rooms. Also, the use of computer based operator aids is en evolving area. In order to assist on the development of methods and criteria and to evaluate the effects of the new design concepts and computerized support systems on operator performance, research simulators with advanced control rooms technology, such the IEN's Human System Interface Laboratory, will provide the necessary setting. (author)
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UNEXMIN H2020 Project: an underwater explorer for flooded mines
Lopes, Luís; Zajzon, Norbert; Bodo, Balázs; Henley, Stephen; Žibret, Gorazd; Almeida, José; Vörös, Csaba; Horvath, Janos; Dizdarevič, Tatjana; Rossi, Claudio; McLoughlin, Mike
2017-04-01
UNEXMIN (Underwater Explorer for Flooded Mines, Grant Agreement No. 690008, www.unexmin.eu) is a project funded by the European Commission's HORIZON2020 Framework Programme. The project is developing a multi-platform robotic system for the autonomous exploration and mapping of Europe's flooded mines. The robotic system - UX-1 - will use non-invasive methods for the 3D mapping of abandoned flooded mines, bringing new important geological and mineralogical data that cannot be currently obtained by any other means. This technology will allow the development or update of geological models at local and regional levels. The data collected will then be used to consider new exploration scenarios for the possible re-opening of some of Europe's abandoned mines which may still contain valuable resources of strategic minerals. The deployment of a multi-robotic system in such a confined environment poses challenges that must be overcome so that the robots can work autonomously, without damaging the equipment and the mine itself. Key challenges are related to the i) structural design for robustness and resilience, ii) localization, navigation and 3D mapping, iii) guidance, propulsion and control, iv) autonomous operation and supervision, v) data processing, interpretation and evaluation. The scientific instrument array is currently being tested, built and tailored for the submersible: pH, electrical conductivity, pressure and temperature analyzers and a water sampler (water sampling methods), a magnetic field analyzer, a gamma-ray counter and a sub-bottom profiler (geophysical methods) and a multispectral and UV fluorescence imaging units (optical observation methods). The instruments have been selected to generate data of maximum geoscientific interest, considering the limiting factors of the submerged underground environment, the necessary robotic functions, the size for the robot and other constraints. Other crucial components for the robot's functionality (such as movement
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Imhoff, M.; Bounoua, L.
2004-12-01
A unique combination of satellite and socio-economic data were used to explore the relationship between human consumption and the carbon cycle. Biophysical models were applied to consumption data to estimate the annual amount of Earth's terrestrial net primary production humans require for food, fiber and fuel using the same modeling architecture as satellite-supported NPP measurements. The amount of Earth's NPP required to support human activities is a powerful measure of the aggregate human impacts on the biosphere and indicator of societal vulnerability to climate change. Equations were developed estimating the amount of landscape-level NPP required to generate all the products consumed by 230 countries including; vegetal foods, meat, milk, eggs, wood, fuel-wood, paper and fiber. The amount of NPP required was calculated on a per capita basis and projected onto a global map of population to create a spatially explicit map of NPP-carbon demand in units of elemental carbon. NPP demand was compared to a map of Earth's average annual net primary production or supply created using 17 years (1982-1998) of AVHRR vegetation index to produce a geographically accurate balance sheet of terrestrial NPP-carbon supply and demand. Globally, humans consume 20 percent of Earth's total net primary production on land. Regionally the NPP-carbon balance percentage varies from 6 to over 70 percent and locally from near 0 to over 30,000 percent in major urban areas. The uneven distribution of NPP-carbon supply and demand, indicate the degree to which various human populations rely on NPP imports, are vulnerable to climate change and suggest policy options for slowing future growth in NPP demand.
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Exploring the knowledge ‘base’ of practitioners in the delivery of sustainable regeneration projects
Directory of Open Access Journals (Sweden)
Julius Akotia
2016-06-01
Full Text Available In recent years, sustainable regeneration has been recognised as being of major economic and social concern in the world. In the UK for instance, government has initiated a number of policies and evaluation methods to deal with some of the environmental problems associated with regeneration projects. However, the post construction evaluation of these projects has often resulted in them being seen as not achieving their set objectives. Attempts aimed at evaluating the impact of sustainability by built environment practitioners have primarily been limited to their assessment of the projects’ potential environmental impacts, with the associated socio-economic impacts being neglected. There has not been any well-defined built environment research that has been able to deal holistically with the broader issues of sustainability in terms of benefits/impacts of the regeneration projects to the communities concerned. The findings of an exploratory study that adopted a semi-structured interview approach for data collection, to explore the knowledge and understanding of fifteen practitioners who are often involved in the delivery of these projects are presented. The findings reveal a lack of knowledge and understanding of sustainability as well as structured mechanism/practices for evaluating the socio-economic sustainability factors in relation to regeneration projects.
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Improving Faculty Perceptions of and Intent to Use Simulation: An Intervention Project
Tucker, Charles
2013-01-01
Human patient simulation is an innovative teaching strategy that can facilitate practice development and preparation for entry into today's healthcare environment for nursing students. Unfortunately, the use of human patient simulation has been limited due to the perceptions of nursing faculty members. This project sought to explore those…
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Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project.
Bastiani, Matteo; Andersson, Jesper L R; Cordero-Grande, Lucilio; Murgasova, Maria; Hutter, Jana; Price, Anthony N; Makropoulos, Antonios; Fitzgibbon, Sean P; Hughes, Emer; Rueckert, Daniel; Victor, Suresh; Rutherford, Mary; Edwards, A David; Smith, Stephen M; Tournier, Jacques-Donald; Hajnal, Joseph V; Jbabdi, Saad; Sotiropoulos, Stamatios N
2018-05-28
The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic and environmental influences on brain development, and the relation between connectivity and neurocognitive function. A large set of multi-modal MRI data from fetuses and newborn infants is currently being acquired, along with genetic, clinical and developmental information. In this overview, we describe the neonatal diffusion MRI (dMRI) image processing pipeline and the structural connectivity aspect of the project. Neonatal dMRI data poses specific challenges, and standard analysis techniques used for adult data are not directly applicable. We have developed a processing pipeline that deals directly with neonatal-specific issues, such as severe motion and motion-related artefacts, small brain sizes, high brain water content and reduced anisotropy. This pipeline allows automated analysis of in-vivo dMRI data, probes tissue microstructure, reconstructs a number of major white matter tracts, and includes an automated quality control framework that identifies processing issues or inconsistencies. We here describe the pipeline and present an exemplar analysis of data from 140 infants imaged at 38-44 weeks post-menstrual age. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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The Hudson River Plume: Exploring Human Impact on the Coastal Environment
McDonnell, Janice; Duncan, Ravit; Lichtenwalner, C. Sage; Dunbar, Laura
2010-01-01
The Hudson River Watershed contains a variety of geologic, topographic, climatic, and hydrologic features and a diversity of land-use patterns--making it an ideal model for studying human impact on the coastal environment. In this article, the authors present the Hudson River Plume (HRP), a problem-based online module that explores nonpoint-source…
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ADP Analysis project for the Human Resources Management Division
Tureman, Robert L., Jr.
1993-01-01
The ADP (Automated Data Processing) Analysis Project was conducted for the Human Resources Management Division (HRMD) of NASA's Langley Research Center. The three major areas of work in the project were computer support, automated inventory analysis, and an ADP study for the Division. The goal of the computer support work was to determine automation needs of Division personnel and help them solve computing problems. The goal of automated inventory analysis was to find a way to analyze installed software and usage on a Macintosh. Finally, the ADP functional systems study for the Division was designed to assess future HRMD needs concerning ADP organization and activities.
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van der Ploeg, Lidewij; Vanclay, Frank
2017-01-01
This paper identifies and addresses the challenges of implementing the corporate responsibility to respect human rights in practice at project sites. To support on-ground operational staff, we offer the Human Rights Sphere (HRS), a practical tool we developed from empirical research in three
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van der Ploeg, Lidewij; Vanclay, Frank
2017-01-01
This paper identifies and addresses the challenges of implementing the corporate responsibility to respect human rights in practice at project sites. To support on-ground operational staff, we offer the Human Rights Sphere (HRS), a practical tool we developed from empirical research in three
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Layas, Fatma; Petrie, Helen
2016-01-01
There have been a number of crowdsourcing projects to support people with disabilities. However, there is little exploration of what motivates people to participate in such crowdsourcing projects. In this study we investigated how different motivational factors can affect the participation of people in a crowdsourcing project to support visually disabled students. We are developing "DescribeIT", a crowdsourcing project to support blind and partially students by having sighted people describe images in digital learning resources. We investigated participants' behavior of the DescribeIT project using three conditions: one intrinsic motivation condition and two extrinsic motivation conditions. The results showed that participants were significantly intrinsically motivated to participate in the DescribeIT project. In addition, participants' intrinsic motivation dominated the effect of the two extrinsic motivational factors in the extrinsic conditions.
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Human Exploration of the Solar System by 2100
Litchford, Ronald J.
2017-01-01
It has been suggested that the U.S., in concert with private entities and international partners, set itself on a course to accomplish human exploration of the solar system by the end of this century. This is a strikingly bold vision intended to revitalize the aspirations of HSF in service to the security, economic, and scientific interests of the nation. Solar system distance and time scales impose severe requirements on crewed space transportation systems, however, and fully realizing all objectives in support of this goal will require a multi-decade commitment employing radically advanced technologies - most prominently, space habitats capable of sustaining and protecting life in harsh radiation environments under zero gravity conditions and in-space propulsion technologies capable of rapid deep space transits with earth return, the subject of this paper. While near term mission destinations such as the moon and Mars can be accomplished with chemical propulsion and/or high power SEP, fundamental capability constraints render these traditional systems ineffective for solar system wide exploration. Nuclear based propulsion and alternative energetic methods, on the other hand, represent potential avenues, perhaps the only viable avenues, to high specific power space transport evincing reduced trip time, reduced IMLEO, and expanded deep space reach. Here, very long term HSF objectives for solar system wide exploration are examined in relation to the advanced propulsion technology solution landscape including foundational science, technical/engineering challenges, and developmental prospects.
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Directory of Open Access Journals (Sweden)
A. I. Archakov
2013-12-01
Full Text Available The international project Human Proteome (PHP, being a logical continuation of the project Human Genome, was started on September 23, 2010. In correspondence with the genocentric approach, the PHP aim is to prepare a catalogue of all human proteins and to decipher a network of their interactions. The PHP implementation difficulties arise because the research subject itself – proteome – is much more complicated than genome. The major problem is the insufficient sensitivity of proteome methods that does not allow detecting low- and ultralow-copy proteins. Bad reproducibility of proteome methods and the lack of so-called “gold standard” is the second major complicacy in PHP implementation. The third problem is the dynamic character of proteome, its instability in time. The paper deals with possible variants of overcoming these complicacies, preventing from successful implementation of PHP.
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Los Alamos Science: The Human Genome Project. Number 20, 1992
Cooper, N. G.; Shea, N. eds.
1992-01-01
This document provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.
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Los Alamos Science: The Human Genome Project. Number 20, 1992
Energy Technology Data Exchange (ETDEWEB)
Cooper, N G; Shea, N [eds.
1992-01-01
This article provides a broad overview of the Human Genome Project, with particular emphasis on work being done at Los Alamos. It tries to emphasize the scientific aspects of the project, compared to the more speculative information presented in the popular press. There is a brief introduction to modern genetics, including a review of classic work. There is a broad overview of the Genome Project, describing what the project is, what are some of its major five-year goals, what are major technological challenges ahead of the project, and what can the field of biology, as well as society expect to see as benefits from this project. Specific results on the efforts directed at mapping chromosomes 16 and 5 are discussed. A brief introduction to DNA libraries is presented, bearing in mind that Los Alamos has housed such libraries for many years prior to the Genome Project. Information on efforts to do applied computational work related to the project are discussed, as well as experimental efforts to do rapid DNA sequencing by means of single-molecule detection using applied spectroscopic methods. The article introduces the Los Alamos staff which are working on the Genome Project, and concludes with brief discussions on ethical, legal, and social implications of this work; a brief glimpse of genetics as it may be practiced in the next century; and a glossary of relevant terms.
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Kates, Earl B.
2016-01-01
Despite significant investments made by organizations to implement ERP systems and prior research that explored contributing factors of ERP failure, the ERP implementation success rate continues to remain low in practice. Increased technology usage in the workplace coupled with higher dependency on technology to complete project tasks often leads…
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Dunkerly-Bean, Judith; Bean, Thomas; Alnajjar, Khaled
2014-01-01
The purpose of this study was to explore middle school (grade 6-8) students' understanding and interpretation of human rights issues with local and global implications as they engaged in the process of creating a film after reading print and multimedia texts and participating in human rights education activities. As the students explored…
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Explore the Human-Based Teaching for the Professional Course of Materials Science and Engineering
Zhao, Yiping; Chen, Li; Zhang, Yufeng
2008-01-01
As viewed from two sides such as teacher and student, in this article, we explore the human-based teaching reform for the college professional course of materials Science and Engineering, point out the qualities and conditions that professional teacher should possess in the process of human-based teaching reform of professional course and the…
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Abell, Paul A.; Rivkin, Andy S.
2014-01-01
The joint ESA and NASA Asteroid Impact and Deflection Assessment (AIDA) mission will directly address aspects of NASA's Asteroid Initiative and will contribute to future human exploration. The NASA Asteroid Initiative is comprised of two major components: the Grand Challenge and the Asteroid Mission. The first component, the Grand Challenge, focuses on protecting Earth's population from asteroid impacts by detecting potentially hazardous objects with enough warning time to either prevent them from impacting the planet, or to implement civil defense procedures. The Asteroid Mission, involves sending astronauts to study and sample a near-Earth asteroid (NEA) prior to conducting exploration missions of the Martian system, which includes Phobos and Deimos. AIDA's primary objective is to demonstrate a kinetic impact deflection and characterize the binary NEA Didymos. The science and technical data obtained from AIDA will aid in the planning of future human exploration missions to NEAs and other small bodies. The dual robotic missions of AIDA, ESA's Asteroid Impact Monitor (AIM) and NASA's Double Asteroid Redirection Test (DART), will provide a great deal of technical and engineering data on spacecraft operations for future human space exploration while conducting in-depth scientific examinations of the binary target Didymos both prior to and after the kinetic impact demonstration. The knowledge gained from this mission will help identify asteroidal physical properties in order to maximize operational efficiency and reduce mission risk for future small body missions. The AIDA data will help fill crucial strategic knowledge gaps concerning asteroid physical characteristics that are relevant for human exploration considerations at similar small body destinations.
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Tarkhov, P V; Matsenko, A M; Krugliak, A P; Derkach, Zh V
2012-01-01
To reach normal competitiveness in world division of labour, investment projects should stimulate development of human capital towards advance of modern technologies and organizational development of all types of labour. At present time there are only separate calculations of certain types of people's health damage and completely disparate matters of damage compensation exceptionally for chemical contamination effects. The purpose of the paper is development of algorithms to provide hygienic welfare of human capital in investment projects. For this purpose in investments assessment and hygienic examination it is necessary to apply complete and comprehensive (systematic) evaluation of all factors that influence human capital welfare and practical hygienic and research institutions should be focused on systematic elimination of possible dangers and risks of investment projects.
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INTEGRITY -- Integrated Human Exploration Mission Simulation Facility
Henninger, D.; Tri, T.; Daues, K.
It is proposed to develop a high -fidelity ground facil ity to carry out long-duration human exploration mission simulations. These would not be merely computer simulations - they would in fact comprise a series of actual missions that just happen to stay on earth. These missions would include all elements of an actual mission, using actual technologies that would be used for the real mission. These missions would also include such elements as extravehicular activities, robotic systems, telepresence and teleoperation, surface drilling technology--all using a simulated planetary landscape. A sequence of missions would be defined that get progressively longer and more robust, perhaps a series of five or six missions over a span of 10 to 15 years ranging in durat ion from 180 days up to 1000 days. This high-fidelity ground facility would operate hand-in-hand with a host of other terrestrial analog sites such as the Antarctic, Haughton Crater, and the Arizona desert. Of course, all of these analog mission simulations will be conducted here on earth in 1-g, and NASA will still need the Shuttle and ISS to carry out all the microgravity and hypogravity science experiments and technology validations. The proposed missions would have sufficient definition such that definitive requirements could be derived from them to serve as direction for all the program elements of the mission. Additionally, specific milestones would be established for the "launch" date of each mission so that R&D programs would have both good requirements and solid milestones from which to build their implementation plans. Mission aspects that could not be directly incorporated into the ground facility would be simulated via software. New management techniques would be developed for evaluation in this ground test facility program. These new techniques would have embedded metrics which would allow them to be continuously evaluated and adjusted so that by the time the sequence of missions is completed
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Johnson, James E.; Conley, Cassie; Siegel, Bette
2015-01-01
As systems, technologies, and plans for the human exploration of Mars and other destinations beyond low Earth orbit begin to coalesce, it is imperative that frequent and early consideration is given to how planetary protection practices and policy will be upheld. While the development of formal planetary protection requirements for future human space systems and operations may still be a few years from fruition, guidance to appropriately influence mission and system design will be needed soon to avoid costly design and operational changes. The path to constructing such requirements is a journey that espouses key systems engineering practices of understanding shared goals, objectives and concerns, identifying key stakeholders, and iterating a draft requirement set to gain community consensus. This paper traces through each of these practices, beginning with a literature review of nearly three decades of publications addressing planetary protection concerns with respect to human exploration. Key goals, objectives and concerns, particularly with respect to notional requirements, required studies and research, and technology development needs have been compiled and categorized to provide a current 'state of knowledge'. This information, combined with the identification of key stakeholders in upholding planetary protection concerns for human missions, has yielded a draft requirement set that might feed future iteration among space system designers, exploration scientists, and the mission operations community. Combining the information collected with a proposed forward path will hopefully yield a mutually agreeable set of timely, verifiable, and practical requirements for human space exploration that will uphold international commitment to planetary protection.
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Human Exploration Spacecraft Testbed for Integration and Advancement (HESTIA)
Banker, Brian F.; Robinson, Travis
2016-01-01
The proposed paper will cover ongoing effort named HESTIA (Human Exploration Spacecraft Testbed for Integration and Advancement), led at the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) to promote a cross-subsystem approach to developing Mars-enabling technologies with the ultimate goal of integrated system optimization. HESTIA also aims to develop the infrastructure required to rapidly test these highly integrated systems at a low cost. The initial focus is on the common fluids architecture required to enable human exploration of mars, specifically between life support and in-situ resource utilization (ISRU) subsystems. An overview of the advancements in both integrated technologies, in infrastructure, in simulation, and in modeling capabilities will be presented, as well as the results and findings of integrated testing,. Due to the enormous mass gear-ratio required for human exploration beyond low-earth orbit, (for every 1 kg of payload landed on Mars, 226 kg will be required on Earth), minimization of surface hardware and commodities is paramount. Hardware requirements can be minimized by reduction of equipment performing similar functions though for different subsystems. If hardware could be developed which meets the requirements of both life support and ISRU it could result in the reduction of primary hardware and/or reduction in spares. Minimization of commodities to the surface of mars can be achieved through the creation of higher efficiency systems producing little to no undesired waste, such as a closed-loop life support subsystem. Where complete efficiency is impossible or impractical, makeup commodities could be manufactured via ISRU. Although, utilization of ISRU products (oxygen and water) for crew consumption holds great promise of reducing demands on life support hardware, there exist concerns as to the purity and transportation of commodities. To date, ISRU has been focused on production rates and purities for
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Humanities data in R exploring networks, geospatial data, images, and text
Arnold, Taylor
2015-01-01
This pioneering book teaches readers to use R within four core analytical areas applicable to the Humanities: networks, text, geospatial data, and images. This book is also designed to be a bridge: between quantitative and qualitative methods, individual and collaborative work, and the humanities and social scientists. Exploring Humanities Data Types with R does not presuppose background programming experience. Early chapters take readers from R set-up to exploratory data analysis (continuous and categorical data, multivariate analysis, and advanced graphics with emphasis on aesthetics and facility). Everything is hands-on: networks are explained using U.S. Supreme Court opinions, and low-level NLP methods are applied to short stories by Sir Arthur Conan Doyle. The book’s data, code, appendix with 100 basic programming exercises and solutions, and dedicated website are valuable resources for readers. The methodology will have wide application in classrooms and self-study for the humanities, but also for use...
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Lynch, Margaret M.
2013-01-01
This study explores the meaning project managers (PMs) make of their project environment, how they lead their teams and have incorporate complexity into their project management approach. The exploration of the PM's developmental level and meaning making offers a different angle on the project management and leadership literature. The study…
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Nowinski, Wieslaw L.; Thirunavuukarasuu, Arumugam; Volkau, Ihar; Marchenko, Yevgen; Aminah, Bivi; Gelas, Arnaud; Huang, Su; Lee, Looi Chow; Liu, Jimin; Ng, Ting Ting; Nowinska, Natalia G.; Qian, Guoyu Yu; Puspitasari, Fiftarina; Runge, Val M.
2009-01-01
The increasing complexity of human body models enabled by advances in diagnostic imaging, computing, and growing knowledge calls for the development of a new generation of systems for intelligent exploration of these models. Here, we introduce a novel paradigm for the exploration of digital body models illustrating cerebral vasculature. It enables…
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Abell, Paul A.; Rivkin, Andrew S.
2015-01-01
Introduction: Robotic missions to small bodies will directly address aspects of NASA's Asteroid Initiative and will contribute to future human exploration and planetary defense. The NASA Asteroid Initiative is comprised of two major components: the Grand Challenge and the Asteroid Mission. The first component, the Grand Challenge, focuses on protecting Earth's population from asteroid impacts by detecting potentially hazardous objects with enough warning time to either prevent them from impacting the planet, or to implement civil defense procedures. The Asteroid Mission involves sending astronauts to study and sample a near-Earth asteroid (NEA) prior to conducting exploration missions of the Martian system, which includes Phobos and Deimos. The science and technical data obtained from robotic precursor missions that investigate the surface and interior physical characteristics of an object will help identify the pertinent physical properties that will maximize operational efficiency and reduce mission risk for both robotic assets and crew operating in close proximity to, or at the surface of, a small body. These data will help fill crucial strategic knowledge gaps (SKGs) concerning asteroid physical characteristics that are relevant for human exploration considerations at similar small body destinations. These data can also be applied for gaining an understanding of pertinent small body physical characteristics that would also be beneficial for formulating future impact mitigation procedures. Small Body Strategic Knowledge Gaps: For the past several years NASA has been interested in identifying the key SKGs related to future human destinations. These SKGs highlight the various unknowns and/or data gaps of targets that the science and engineering communities would like to have filled in prior to committing crews to explore the Solar System. An action team from the Small Bodies Assessment Group (SBAG) was formed specifically to identify the small body SKGs under the
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Exploring the Strategic Role of Human Resource Development in Organizational Crisis Management
Wang, Jia; Hutchins, Holly M.; Garavan, Thomas N.
2009-01-01
Crisis management has been a largely overlooked territory in human resource development (HRD) despite the increasingly recognized impact of organizational crises on the individual and organizational performance. This article explores the strategic role of HRD in the context of organizational crisis management using Garavan's strategic HRD model as…
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Grimwood, Bryan S. R.; Haberer, Alexa; Legault, Maria
2015-01-01
This paper explores and critically interprets the role wilderness travel may play in fostering environmental sustainability. The paper draws upon two qualitative studies that sought to understand human-nature relationships as experienced by different groups of wilderness travel leaders in Canada. According to leaders involved in the studies,…
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Radiation Environments for Future Human Exploration Throughout the Solar System.
Schwadron, N.; Gorby, M.; Linker, J.; Riley, P.; Torok, T.; Downs, C.; Spence, H. E.; Desai, M. I.; Mikic, Z.; Joyce, C. J.; Kozarev, K. A.; Townsend, L. W.; Wimmer-Schweingruber, R. F.
2016-12-01
Acute space radiation hazards pose one of the most serious risks to future human and robotic exploration. The ability to predict when and where large events will occur is necessary in order to mitigate their hazards. The largest events are usually associated with complex sunspot groups (also known as active regions) that harbor strong, stressed magnetic fields. Highly energetic protons accelerated very low in the corona by the passage of coronal mass ejection (CME)-driven compressions or shocks and from flares travel near the speed of light, arriving at Earth minutes after the eruptive event. Whether these particles actually reach Earth, the Moon, Mars (or any other point) depends on their transport in the interplanetary magnetic field and their magnetic connection to the shock. Recent contemporaneous observations during the largest events in almost a decade show the unique longitudinal distributions of this ionizing radiation broadly distributed from sources near the Sun and yet highly isolated during the passage of CME shocks. Over the last decade, we have observed space weather events as the solar wind exhibits extremely low densities and magnetic field strengths, representing states that have never been observed during the space age. The highly abnormal solar activity during cycles 23 and 24 has caused the longest solar minimum in over 80 years and continues into the unusually small solar maximum of cycle 24. As a result of the remarkably weak solar activity, we have also observed the highest fluxes of galactic cosmic rays in the space age and relatively small particle radiation events. We have used observations from LRO/CRaTER to examine the implications of these highly unusual solar conditions for human space exploration throughout the inner solar system. While these conditions are not a show-stopper for long-duration missions (e.g., to the Moon, an asteroid, or Mars), galactic cosmic ray radiation remains a significant and worsening factor that limits
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Shull, Sarah A.; Gralla, Erica L.; deWeck, Olivier L.; Shishko, Robert
2006-01-01
One of the major logistical challenges in human space exploration is asset management. This paper presents observations on the practice of asset management in support of human space flight to date and discusses a functional-based supply classification and a framework for an integrated database that could be used to improve asset management and logistics for human missions to the Moon, Mars and beyond.
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The Thai-Canadian nuclear human resources development linkage project
International Nuclear Information System (INIS)
Sumitra, Tatchai; Chankow, Nares; Bradley, K.; Bereznai, G.
1998-01-01
The Thai-Canadian Nuclear Human Resources Development Linkage Project (the P roject ) was initiated in 1994 in order to develop the engineering and scientific expertise needed for Thailand to decide whether and how the country can best benefit from the establishment of a nuclear power program. The Project was designed to upgrade current academics and people in industry, and to develop an adequate supply of new technical personnel for academic, industry, utility, regulatory and other government institutions. The key Project objectives included the establishment of a Chair in Nuclear Engineering at Chulalongkorn University, the upgrading of the current Masters level curriculum, the establishment of undergraduate and doctorate level curricula, development and delivery of an industrial training program for people in industry and government, exchanges of Thai and Canadian academics and industry experts to establish common research programs and teaching interests, and a public education program that was to test in Thailand some of the techniques that have been successfully used in Canada. (author)
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Space exploration and colonization - Towards a space faring society
Hammond, Walter E.
1990-01-01
Development trends of space exploration and colonization since 1957 are reviewed, and a five-phase evolutionary program planned for the long-term future is described. The International Geosphere-Biosphere program which is intended to provide the database on enviromental changes of the earth as a global system is considered. Evolution encompasses the anticipated advantages of such NASA observation projects as the Hubble Space Telescope, the Gamma Ray Observatory, the Advanced X-Ray Astrophysics Facility, and the Cosmic Background Explorer. Attention is given to requirements for space colonization, including development of artificial gravity and countermeasures to mitigate zero gravity problems; robotics and systems aimed to minimize human exposure to the space environment; the use of nuclear propulsion; and international collaboration on lunar-Mars projects. It is recommended that nuclear energy sources be developed for both propulsion and as extraterrestrial power plants.
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Solar Energetic Particles Events and Human Exploration: Measurements in a Space Habitat
Narici, L.; Berrilli, F.; Casolino, M.; Del Moro, D.; Forte, R.; Giovannelli, L.; Martucci, M.; Mergè, M.; Picozza, P.; Rizzo, A.; Scardigli, S.; Sparvoli, R.; Zeitlin, C.
2016-12-01
Solar activity is the source of Space Weather disturbances. Flares, CME and coronal holes modulate physical conditions of circumterrestrial and interplanetary space and ultimately the fluxes of high-energy ionized particles, i.e., solar energetic particle (SEP) and galactic cosmic ray (GCR) background. This ionizing radiation affects spacecrafts and biological systems, therefore it is an important issue for human exploration of space. During a deep space travel (for example the trip to Mars) radiation risk thresholds may well be exceeded by the crew, so mitigation countermeasures must be employed. Solar particle events (SPE) constitute high risks due to their impulsive high rate dose. Forecasting SPE appears to be needed and also specifically tailored to the human exploration needs. Understanding the parameters of the SPE that produce events leading to higher health risks for the astronauts in deep space is therefore a first priority issue. Measurements of SPE effects with active devices in LEO inside the ISS can produce important information for the specific SEP measured, relative to the specific detector location in the ISS (in a human habitat with a shield typical of manned space-crafts). Active detectors can select data from specific geo-magnetic regions along the orbits, allowing geo-magnetic selections that best mimic deep space radiation. We present results from data acquired in 2010 - 2012 by the detector system ALTEA inside the ISS (18 SPEs detected). We compare this data with data from the detector Pamela on a LEO satellite, with the RAD data during the Curiosity Journey to Mars, with GOES data and with several Solar physical parameters. While several features of the radiation modulation are easily understood by the effect of the geomagnetic field, as an example we report a proportionality of the flux in the ISS with the energetic proton flux measured by GOES, some features appear more difficult to interpret. The final goal of this work is to find the
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Tachibana, Koji; Tachibana, Shoichi; Inoue, Natsuhiko
2017-11-01
Human space exploration requires massive budgets every fiscal year. Especially under severe financial constraint conditions, governments are forced to justify to society why spending so much tax revenue for human space exploration is worth the cost. The value of human space exploration might be estimated in many ways, but its social significance and cost-effectiveness are two key ways to gauge that worth. Since these measures should be applied country by country because sociopolitical conditions differ in each country and must be taken into consideration, the study on the social significance of human space exploration must take the coloration of a case-study. This paper, focusing on the case of Japan with surveying Japanese literary and national documents as well as taking its sociopolitical conditions into account, examines the social significance of human space exploration. First, we give an overview of the circumstances surrounding Japan's human space exploration program. Derived from the statements of such relevant parties as scholars, journalists, policy makers, and astronauts, this overview indicates that the main concerns about human space exploration in Japan are its social significance and cost-effectiveness (Section 1). Next, an overview of behavioral science-an essential field for human space exploration (referred to in this paper as space behavioral science) that provides support for astronauts-is presented from the perspective of stress research in isolated and confined environments (Section 2). We then give two examples of where such knowledge from space behavioral science research has been applied to terrestrial isolated and confined environments. One is JAXA's support in 2009 for people who were vulnerable to infection by a new strain of flu and accordingly placed in an isolated and confined facility under the Infectious Disease Law and the Quarantine Law. The other is NASA's support in 2010 for Chilean mine workers who were trapped 700 m
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The DESMEX Project - Deep Electromagnetic Sounding for Mineral EXploration
Meyer, U.; Becken, M.; Stolz, R.; Nittinger, C.; Cherevatova, M.; Siemon, B.; Martin, T.; Petersen, H.; Steuer, A.
2017-12-01
The DESMEX project (Deep Electromagnetic Sounding for Mineral Exploration) aims to develop independent semi-airborne frequency domain systems for mineral exploration down to depths of 1 km and deeper. Two different helicopter-towed systems are being designed and tested using source installations on ground. One system uses among other equipment conventional three axis induction coils, a 3D-fluxgate and a high precision inertial motion unit. The use of the two different magnetometers allows to record data in a broad frequency range from 1 Hz to 10 kHz. The second system uses a newly developed SQUID-based sensing system of a similar frequency range and a self made inertial motion unit. Horizontal electric dipole transmitters provided by the Leibniz Institute for Applied Geophysics in Hannover and the Institute of Geophysics and Meteorology of the University in Cologne are used as ground based sources. First system tests showed a good performance of both systems with general noise levels below 50 pT/root(Hz). Test flights above the common survey area proved that the desired depth of investigation can be achieved and that the data is consistent with the subsurface conductivity structures. In order to verify the data acquired from the newly developed system at shallow depths and to provide a better starting model for later inversion calculations helicopter borne frequency domain electromagnetics has been acquired and fully processed over the test site Schleiz - Greiz in Germany. To further relate the subsurface conductivity models to the subsurface geology and mineralogy, petrophysical investigations have been performed on rock samples from the site of investigation and analogue samples.
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Organizations, projects and culture
J. van Cleeff; Pieter van Nispen tot Pannerden
2016-01-01
Purpose: to explore and demonstrate the effects of organizational culture on projects, in particular project culture and project management style. Methodology/approach: descriptive and explorative; through students’ groups. Findings: the cultural relationship between organizations, their projects
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A Collaborative Media Production Project on Human Rights: Bridging Everyday and Media Education
Haydari, Nazan; Kara, Mustafa
2015-01-01
Given the importance of media institutions and universities as spaces of knowledge productions, development of "critical media pedagogy" becomes crucial for the establishment of a responsible and ethical media environment. Drawing from the collaborative project of The First Step into Human Rights: I do not do it!--A Short Film Project on…
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Abell, Paul; Mazanek, Dan; Barbee, Brent; Landis, Rob; Johnson, Lindley; Yeomans, Don; Friedensen, Victoria
2013-01-01
Over the past several years, much attention has been focused on human exploration of near-Earth asteroids (NEAs) and planetary defence. Two independent NASA studies examined the feasibility of sending piloted missions to NEAs, and in 2009, the Augustine Commission identified NEAs as high profile destinations for human exploration missions beyond the Earth-Moon system as part of the Flexible Path. More recently the current U.S. presidential administration directed NASA to include NEAs as destinations for future human exploration with the goal of sending astronauts to a NEA in the mid to late 2020s. This directive became part of the official National Space Policy of the United States of America as of June 28, 2010. With respect to planetary defence, in 2005 the U.S. Congress directed NASA to implement a survey program to detect, track, and characterize NEAs equal or greater than 140 m in diameter in order to access the threat from such objects to the Earth. The current goal of this survey is to achieve 90% completion of objects equal or greater than 140 m in diameter by 2020.
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Response to "The Shaky Legal Foundations of the Global Human Rights Education Project"
Tibbitts, Felisa
2015-01-01
This article is a response to "The Shaky Legal Foundations of the Global Human Rights Education Project," an article written by Barend Vlaardingerbroek, in which Vlaardingerbroek characterizes current practices of human rights education (HRE) as having an overriding agenda of activism, one that can draw on an ideologically-driven…
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Turner, R.; Huemann, M.; Keegan, A.
2008-01-01
As part of a wider study into human resource management (HRM) practices in project-oriented organizations, we investigated the issue of employee well-being. Project-oriented organizations adopt temporary work processes to deliver products and services to clients. This creates a dynamic work
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Human activity and climate variability project: annual report 2001
International Nuclear Information System (INIS)
Harle, K.J.; Heijnis, H.; Henderson-Sellers, A.; Sharmeen, S.; Zahorowski, W.
2002-01-01
Knowledge of the state of the Australian environment, including natural climate variability, prior to colonial settlement is vital if we are to define and understand the impact of over two hundred years of post-industrial human activity on our landscape. ANSTO, in conjunction with university partners, is leading a major research effort to provide natural archives of human activity and climate variability over the last 500 years in Australia, utilising a variety of techniques, including lead-210 and radiocarbon dating and analyses of proxy indicators (such as microfossils) as well as direct evidence (such as trace elements) of human activity and climate variability. The other major project objectives were to contribute to the understanding of the impact of human induced and natural aerosols in the East Asian region on climate through analysis and sourcing of fine particles and characterisation of air samples using radon concentrations and to contribute to the improvement of land surface parameterisation schemes and investigate the potential to use stable isotopes to improve global climate models and thus improve our understanding of future climate
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Human vocal attractiveness as signaled by body size projection.
Directory of Open Access Journals (Sweden)
Yi Xu
Full Text Available Voice, as a secondary sexual characteristic, is known to affect the perceived attractiveness of human individuals. But the underlying mechanism of vocal attractiveness has remained unclear. Here, we presented human listeners with acoustically altered natural sentences and fully synthetic sentences with systematically manipulated pitch, formants and voice quality based on a principle of body size projection reported for animal calls and emotional human vocal expressions. The results show that male listeners preferred a female voice that signals a small body size, with relatively high pitch, wide formant dispersion and breathy voice, while female listeners preferred a male voice that signals a large body size with low pitch and narrow formant dispersion. Interestingly, however, male vocal attractiveness was also enhanced by breathiness, which presumably softened the aggressiveness associated with a large body size. These results, together with the additional finding that the same vocal dimensions also affect emotion judgment, indicate that humans still employ a vocal interaction strategy used in animal calls despite the development of complex language.
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A Vision for the Exploration of Mars: Robotic Precursors Followed by Humans to Mars Orbit in 2033
Sellers, Piers J.; Garvin, James B.; Kinney, Anne L.; Amato, Michael J.; White, Nicholas E.
2012-01-01
The reformulation of the Mars program gives NASA a rare opportunity to deliver a credible vision in which humans, robots, and advancements in information technology combine to open the deep space frontier to Mars. There is a broad challenge in the reformulation of the Mars exploration program that truly sets the stage for: 'a strategic collaboration between the Science Mission Directorate (SMD), the Human Exploration and Operations Mission Directorate (HEOMD) and the Office of the Chief Technologist, for the next several decades of exploring Mars'.Any strategy that links all three challenge areas listed into a true long term strategic program necessitates discussion. NASA's SMD and HEOMD should accept the President's challenge and vision by developing an integrated program that will enable a human expedition to Mars orbit in 2033 with the goal of returning samples suitable for addressing the question of whether life exists or ever existed on Mars
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Using Pareto optimality to explore the topology and dynamics of the human connectome.
Avena-Koenigsberger, Andrea; Goñi, Joaquín; Betzel, Richard F; van den Heuvel, Martijn P; Griffa, Alessandra; Hagmann, Patric; Thiran, Jean-Philippe; Sporns, Olaf
2014-10-05
Graph theory has provided a key mathematical framework to analyse the architecture of human brain networks. This architecture embodies an inherently complex relationship between connection topology, the spatial arrangement of network elements, and the resulting network cost and functional performance. An exploration of these interacting factors and driving forces may reveal salient network features that are critically important for shaping and constraining the brain's topological organization and its evolvability. Several studies have pointed to an economic balance between network cost and network efficiency with networks organized in an 'economical' small-world favouring high communication efficiency at a low wiring cost. In this study, we define and explore a network morphospace in order to characterize different aspects of communication efficiency in human brain networks. Using a multi-objective evolutionary approach that approximates a Pareto-optimal set within the morphospace, we investigate the capacity of anatomical brain networks to evolve towards topologies that exhibit optimal information processing features while preserving network cost. This approach allows us to investigate network topologies that emerge under specific selection pressures, thus providing some insight into the selectional forces that may have shaped the network architecture of existing human brains.
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A Quantitative ADME-base Tool for Exploring Human ...
Exposure to a wide range of chemicals through our daily habits and routines is ubiquitous and largely unavoidable within modern society. The potential for human exposure, however, has not been quantified for the vast majority of chemicals with wide commercial use. Creative advances in exposure science are needed to support efficient and effective evaluation and management of chemical risks, particularly for chemicals in consumer products. The U.S. Environmental Protection Agency Office of Research and Development is developing, or collaborating in the development of, scientifically-defensible methods for making quantitative or semi-quantitative exposure predictions. The Exposure Prioritization (Ex Priori) model is a simplified, quantitative visual dashboard that provides a rank-ordered internalized dose metric to simultaneously explore exposures across chemical space (not chemical by chemical). Diverse data streams are integrated within the interface such that different exposure scenarios for “individual,” “population,” or “professional” time-use profiles can be interchanged to tailor exposure and quantitatively explore multi-chemical signatures of exposure, internalized dose (uptake), body burden, and elimination. Ex Priori has been designed as an adaptable systems framework that synthesizes knowledge from various domains and is amenable to new knowledge/information. As such, it algorithmically captures the totality of exposure across pathways. It
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The 2003 activities and the workshop of the human resources development project in FNCA
International Nuclear Information System (INIS)
2004-07-01
In 1999, the Project for Human Resources Development (HRD Project) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project there are two kinds of activity; In-workshop activity and Outside-of-workshop activity. The FNCA 2003 Workshop on HRD Project was held on October 8-10, 2003, in Bangkok, Thailand. The Workshop was sponsored by the Ministry of Science and Technology (MOST) of Thailand and the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. Office of Atoms for Peace (OAP) and the Japan Atomic Energy Research Institute (JAERI) acted as the hosts. Participating countries were China, Republic of Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. Unfortunately Indonesia could not attend the Workshop this time. This report consists of presentation papers and materials at the FNCA 2003 Workshop as In-Workshop Activity, a review document of HRD Project for the 6th Coordinators Meeting of FNCA at Tokyo on March, 2004, a letter of proposal from the Project Leader of Japan to the Project Leaders of the participating countries, and training materials of participating countries as Outside-Workshop Activity. (author)
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AP Human Geography and Success on the AP Test
Roncone, John; Newhalfen, Nate
2013-01-01
Classroom projects that explore culture and globalization enhance the curriculum and help students see how geography directly connects to their lives. These authors contend that a project-based approach can supplement the teaching of an AP Human Geography course, and visualize this course as an essential tool for students to truly understand how…
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Medical Data Architecture Project Status
Krihak, M.; Middour, C.; Lindsey, A.; Marker, N.; Wolfe, S.; Winther, S.; Ronzano, K.; Bolles, D.; Toscano, W.; Shaw, T.
2017-01-01
The Medical Data Architecture (MDA) project supports the Exploration Medical Capability (ExMC) risk to minimize or reduce the risk of adverse health outcomes and decrements in performance due to in-flight medical capabilities on human exploration missions. To mitigate this risk, the ExMC MDA project addresses the technical limitations identified in ExMC Gap Med 07: We do not have the capability to comprehensively process medically-relevant information to support medical operations during exploration missions. This gap identifies that the current International Space Station (ISS) medical data management includes a combination of data collection and distribution methods that are minimally integrated with on-board medical devices and systems. Furthermore, there are variety of data sources and methods of data collection. For an exploration mission, the seamless management of such data will enable an increasingly autonomous crew than the current ISS paradigm. The MDA will develop capabilities that support automated data collection, and the necessary functionality and challenges in executing a self-contained medical system that approaches crew health care delivery without assistance from ground support. To attain this goal, the first year of the MDA project focused on reducing technical risk, developing documentation and instituting iterative development processes that established the basis for the first version of MDA software (or Test Bed 1). Test Bed 1 is based on a nominal operations scenario authored by the ExMC Element Scientist. This narrative was decomposed into a Concept of Operations that formed the basis for Test Bed 1 requirements. These requirements were successfully vetted through the MDA Test Bed 1 System Requirements Review, which permitted the MDA project to begin software code development and component integration. This paper highlights the MDA objectives, development processes, and accomplishments, and identifies the fiscal year 2017 milestones and
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Vision of Space Exploration Possibilities and limits of a human space conquest.
Zelenyi, Lev
Few generations of a schoolboys, which later become active and productive space researchers, have been brought up on a science fiction books. These books told us about travels to other Galaxies with velocities larger then velocity of light, meetings with friendly aliens (necessarily with communistic mentalities in Soviet Union books), star wars with ugly space monsters (in the western hemisphere books), etc. Beginning of Space age (4/10/1957) opened the door to a magic box, full of scientific discoveries, made mostly by robotic satellites and spacecraft. However, already the first human space trips clearly demonstrated that space is vigorously hostile to a human beings. Space medicine during the years since Gagarin flight, made an outstanding progress in supporting human presence at orbital stations, but the radiation hazards and problem of hypomagnetism are still opened and there is no visible path to their solution. So the optimistic slogan of 60-ies “Space is Our Place” is not supported by an almost half a century practice. Space never will be a comfortable place for soft and vulnerable humans? There is a general consensus that man will be on Mars during this century (or even its first part). This is very difficult but task it seems to be realistic after the significant advance of modern technologies will be made. But, is there any real need for humans to travel beyond the Mars orbit or to the inner regions of the Solar system? Will the age of Solar system exploration comes to its logical as it was described by Stanislav Lem in his famous book “Return from stars”? The author of this talk has more questions than answers, and thinks that PEX1 Panel on Exploration is just a right place to discuss these usually by passed topics.
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Abell, P. A.; Mazanek, D. D.; Barbee, B. W.; Mink, R. G.; Landis, R. R.; Adamo, D. R.; Johnson, L. N.; Yeomans, D. K.; Reeves, D. M.; Larman, K. T.;
2012-01-01
Over the past several years, much attention has been focused on the human exploration of near-Earth asteroids (NEAs). Two independent NASA studies examined the feasibility of sending piloted missions to NEAs, and in 2009, the Augustine Commission identified NEAs as high profile destinations for human exploration missions beyond the Earth-Moon system as part of the Flexible Path. More recently the current U.S. presidential administration directed NASA to include NEAs as destinations for future human exploration with the goal of sending astronauts to a NEA in the mid to late 2020s. This directive became part of the official National Space Policy of the United States of America as of June 28, 2010.
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Desert RATS 2011: Near-Earth Asteroid Human Exploration Operations
Abercromby, Andrew; Gernhardt, Michael L.; Chappel, Steve
2012-01-01
The Desert Research and Technology Studies (D-RATS) 2011 field test involved the planning and execution of a series of exploration scenarios under operational conditions similar to those that would be expected during a human exploration mission to a near-Earth asteroid (NEA). The focus was on understanding the operations tempo during simulated NEA exploration and the implications of communications latency and limited data bandwidth. Anchoring technologies and sampling techniques were not evaluated due to the immaturity of those technologies and the inability to meaningfully test them at D-RATS. Reduced gravity analogs and simulations are being used to fully evaluate Multi-Mission Space Exploration Vehicle (MMSEV) and extravehicular (EVA) operations and interactions in near-weightlessness at a NEA as part of NASA s integrated analogs program. Hypotheses were tested by planning and performing a series of 1-day simulated exploration excursions comparing test conditions all of which involved a single Deep Space Habitat (DSH) and either zero, one, or two MMSEVs; three or four crewmembers; one of two different communications bandwidths; and a 100-second roundtrip communications latency between the field site and Houston. Excursions were executed at the Black Point Lava Flow test site with a Mission Control Center and Science Support Room at Johnson Space Center (JSC) being operated with 100-second roundtrip communication latency to the field. Crews were composed of astronauts and professional field geologists and teams of Mission Operations, Science, and Education & Public Outreach (EPO) experts also supported the mission simulations each day. Data were collected separately from the Crew, Mission Operations, Science, and EPO teams to assess the test conditions from multiple perspectives. For the operations tested, data indicates practically significant benefits may be realized by including at least one MMSEV and by including 4 versus 3 crewmembers in the NEA exploration
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Potential Applications for Radioisotope Power Systems in Support of Human Exploration Missions
Cataldo, Robert L.; Colozza, Anthony J.; Schmitz, Paul C.
2013-01-01
Radioisotope power systems (RPS) for space applications have powered over 27 U.S. space systems, starting with Transit 4A and 4B in 1961, and more recently with the successful landing of the Mars Science Laboratory rover Curiosity in August 2012. RPS enable missions with destinations far from the Sun with faint solar flux, on planetary surfaces with dense or dusty atmospheres, and at places with long eclipse periods where solar array sizes and energy storage mass become impractical. RPS could also provide an enabling capability in support of human exploration activities. It is envisioned that with the higher power needs of most human mission concepts, a high efficiency thermal-to-electric technology would be required such as the Advanced Stirling Radioisotope generator (ASRG). The ASRG should be capable of a four-fold improvement in efficiency over traditional thermoelectric RPS. While it may be impractical to use RPS as a main power source, many other applications could be considered, such as crewed pressurized rovers, in-situ resource production of propellants, back-up habitat power, drilling, any mobile or remote activity from the main base habitat, etc. This paper will identify potential applications and provide concepts that could be a practical extension of the current ASRG design in providing for robust and flexible use of RPS on human exploration missions.
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Directory of Open Access Journals (Sweden)
Christine Linke
2013-01-01
Full Text Available This article approaches the subject of social robots by focusing on the emotional relations people establish with media and information and communication technology (ICTs in their everyday life. It examines human-technology-relation from a social studies point of view, seeking to raise questions that enable us to make a connection between the research on human relationships and the topic of human-technology relation, especially human-humanoid-relation. In order to explore the human-technology-relations, theoretical ideas of a mediatization of communication and of a ritual interaction order are applied. Ritual theory is particularly used to enable a focus on emotion as a significant dimension in analyzing social technologies. This explorative article refers to empirical findings regarding media communication practices in close relationships. It argues that following the developed approach regarding mediatized and ritualized relational practices, useful insights for a conceptualization of the human-social robot relation can be achieved. The article concludes with remarks regarding the challenge of an empirical approach to human-social robot-relations.
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Energy Technology Data Exchange (ETDEWEB)
None
1990-04-01
The Human Genome Initiative is a worldwide research effort with the goal of analyzing the structure of human DNA and determining the location of the estimated 100,000 human genes. In parallel with this effort, the DNA of a set of model organisms will be studied to provide the comparative information necessary for understanding the functioning of the human genome. The information generated by the human genome project is expected to be the source book for biomedical science in the 21st century and will by of immense benefit to the field of medicine. It will help us to understand and eventually treat many of the more than 4000 genetic diseases that affect mankind, as well as the many multifactorial diseases in which genetic predisposition plays an important role. A centrally coordinated project focused on specific objectives is believed to be the most efficient and least expensive way of obtaining this information. The basic data produced will be collected in electronic databases that will make the information readily accessible on convenient form to all who need it. This report describes the plans for the U.S. human genome project and updates those originally prepared by the Office of Technology Assessment (OTA) and the National Research Council (NRC) in 1988. In the intervening two years, improvements in technology for almost every aspect of genomics research have taken place. As a result, more specific goals can now be set for the project.
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Mercer, Carolyn R.; Jankovsky, Amy L.; Reid, Concha M.; Miller, Thomas B.; Hoberecht, Mark A.
2011-01-01
NASA's Exploration Technology Development Program funded the Energy Storage Project to develop battery and fuel cell technology to meet the expected energy storage needs of the Constellation Program for human exploration. Technology needs were determined by architecture studies and risk assessments conducted by the Constellation Program, focused on a mission for a long-duration lunar outpost. Critical energy storage needs were identified as batteries for EVA suits, surface mobility systems, and a lander ascent stage; fuel cells for the lander and mobility systems; and a regenerative fuel cell for surface power. To address these needs, the Energy Storage Project developed advanced lithium-ion battery technology, targeting cell-level safety and very high specific energy and energy density. Key accomplishments include the development of silicon composite anodes, lithiated-mixed-metal-oxide cathodes, low-flammability electrolytes, and cell-incorporated safety devices that promise to substantially improve battery performance while providing a high level of safety. The project also developed "non-flow-through" proton-exchange-membrane fuel cell stacks. The primary advantage of this technology set is the reduction of ancillary parts in the balance-of-plant--fewer pumps, separators and related components should result in fewer failure modes and hence a higher probability of achieving very reliable operation, and reduced parasitic power losses enable smaller reactant tanks and therefore systems with lower mass and volume. Key accomplishments include the fabrication and testing of several robust, small-scale nonflow-through fuel cell stacks that have demonstrated proof-of-concept. This report summarizes the project s goals, objectives, technical accomplishments, and risk assessments. A bibliography spanning the life of the project is also included.
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The Age of Human-Robot Collaboration: Deep Sea Exploration
Khatib, Oussama
2018-01-18
The promise of oceanic discovery has intrigued scientists and explorers for centuries, whether to study underwater ecology and climate change, or to uncover natural resources and historic secrets buried deep at archaeological sites. Reaching these depth is imperative since factors such as pollution and deep-sea trawling increasingly threaten ecology and archaeological sites. These needs demand a system deploying human-level expertise at the depths, and yet remotely operated vehicles (ROVs) are inadequate for the task. To meet the challenge of dexterous operation at oceanic depths, in collaboration with KAUSTﾒs Red Sea Research Center and MEKA Robotics, Oussama Khatib and the team developed Ocean One, a bimanual humanoid robot that brings immediate and intuitive haptic interaction to oceanic environments. Introducing Ocean One, the haptic robotic avatar During this lecture, Oussama Khatib will talk about how teaming with the French Ministry of Cultureﾒs Underwater Archaeology Research Department, they deployed Ocean One in an expedition in the Mediterranean to Louis XIVﾒs flagship Lune, lying off the coast of Toulon at ninety-one meters. In the spring of 2016, Ocean One became the first robotic avatar to embody a humanﾒs presence at the seabed. Ocean Oneﾒs journey in the Mediterranean marks a new level of marine exploration: Much as past technological innovations have impacted society, Ocean Oneﾒs ability to distance humans physically from dangerous and unreachable work spaces while connecting their skills, intuition, and experience to the task promises to fundamentally alter remote work. Robotic avatars will search for and acquire materials, support equipment, build infrastructure, and perform disaster prevention and recovery operations - be it deep in oceans and mines, at mountain tops, or in space.
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Robot Tracking of Human Subjects in Field Environments
Graham, Jeffrey; Shillcutt, Kimberly
2003-01-01
Future planetary exploration will involve both humans and robots. Understanding and improving their interaction is a main focus of research in the Intelligent Systems Branch at NASA's Johnson Space Center. By teaming intelligent robots with astronauts on surface extra-vehicular activities (EVAs), safety and productivity can be improved. The EVA Robotic Assistant (ERA) project was established to study the issues of human-robot teams, to develop a testbed robot to assist space-suited humans in exploration tasks, and to experimentally determine the effectiveness of an EVA assistant robot. A companion paper discusses the ERA project in general, its history starting with ASRO (Astronaut-Rover project), and the results of recent field tests in Arizona. This paper focuses on one aspect of the research, robot tracking, in greater detail: the software architecture and algorithms. The ERA robot is capable of moving towards and/or continuously following mobile or stationary targets or sequences of targets. The contributions made by this research include how the low-level pose data is assembled, normalized and communicated, how the tracking algorithm was generalized and implemented, and qualitative performance reports from recent field tests.
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Adegoke, J. O.
2015-12-01
Fire is a key agent of change in the African savannas, which are shaped through the complex interactions between trees, C4 grasses, rainfall, temperature, CO2 and fire. These fires and their emitted smoke can have numerous direct and indirect effects on the environment, water resources, air quality, and climate. For instance, veld fires in southern Africa cause large financial losses to agriculture, livestock production and forestry on an annual basis. This study contributes to our understanding of the implications of projected surface temperature evolution in Africa for fire risk, human health and agriculture over the coming decades. We use an ensemble of high-resolution regional climate model simulations of African climate for the 21st century. Regional dowscalings and recent global circulation model projections obtained for Africa indicate that African temperatures are likely to rise at 1.5 times the global rate of temperature increase in the tropics, and at almost twice the global rate of increase in the subtropics. Warming is projected to occur during the 21st century, with increases of 4-6 °C over the subtropics and 3-5 °C over the tropics plausible by the end of the century relative to present-day climate under the A2 (low mitigation) scenario. We explore the significance of the projected warming by documenting increases in projected high fire danger days and heat-wave days. General drying is projected across the continent, even for areas (e.g. tropical Africa) where an increase in rainfall is plausible. This is due to the drastic increases in temperature that are projected, which leads to drier soils (through enhanced evaporation) despite the rainfall increases. This will likely impact negatively on crop yield, particularly on the maize crop that is of crucial importance in terms of African food security.
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The human genome project and the Catholic Church (1)
Moraczewski, Albert S
1991-12-01
The Cathlic Church has not made any formal statements about the Human Genome Project as such. But the present Pope, John Paul II, has commented, albeit very briefly, on various aspects of genetic manipulation. Genetic interventions which are therapeutic (e.g. gene therapy), namely, directed to the correction or amelioration of a disorder are acceptable, in principle, provided they promote the personal well being of the individual being so treated. Genetic interventions which are not therapeutic for the specific individual involved but are experimental and directed primarily to improving humans as biological entities are of dubious moral probity, but are not necessarily to be totally rejected out of hand. To be morally acceptable such genetic intervention should meet certain conditions which include due respect for the given psychological nature of each individual human being. In addition, no harm should be inflicted on the process of human generation, and its fundamental design should not be altered. Any genetic manipulation which results in, or tends to, the creation of groups with different qualities such that there would result a fresh marginalization of these people must be avoided. It has been also suggested by a few that because the Son of God took on a human nature in Jesus Christ, one may not so alter the human genome that a new distinct species would be created....
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Human-Robot Interaction Directed Research Project
Sandor, Aniko; Cross, Ernest V., II; Chang, Mai Lee
2014-01-01
Human-robot interaction (HRI) is a discipline investigating the factors affecting the interactions between humans and robots. It is important to evaluate how the design of interfaces and command modalities affect the human's ability to perform tasks accurately, efficiently, and effectively when working with a robot. By understanding the effects of interface design on human performance, workload, and situation awareness, interfaces can be developed to appropriately support the human in performing tasks with minimal errors and with appropriate interaction time and effort. Thus, the results of research on human-robot interfaces have direct implications for the design of robotic systems. This DRP concentrates on three areas associated with interfaces and command modalities in HRI which are applicable to NASA robot systems: 1) Video Overlays, 2) Camera Views, and 3) Command Modalities. The first study focused on video overlays that investigated how Augmented Reality (AR) symbology can be added to the human-robot interface to improve teleoperation performance. Three types of AR symbology were explored in this study, command guidance (CG), situation guidance (SG), and both (SCG). CG symbology gives operators explicit instructions on what commands to input, whereas SG symbology gives operators implicit cues so that operators can infer the input commands. The combination of CG and SG provided operators with explicit and implicit cues allowing the operator to choose which symbology to utilize. The objective of the study was to understand how AR symbology affects the human operator's ability to align a robot arm to a target using a flight stick and the ability to allocate attention between the symbology and external views of the world. The study evaluated the effects type of symbology (CG and SG) has on operator tasks performance and attention allocation during teleoperation of a robot arm. The second study expanded on the first study by evaluating the effects of the type of
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Ackerman, Michael J.
1993-01-01
As part of the 1986 Long-Range Plan for the National Library of Medicine (NLM), the Planning Panel on Medical Education wrote that NLM should '...thoroughly and systematically investigate the technical requirements for and feasibility of instituting a biomedical images library.' The panel noted the increasing use of images in clinical practice and biomedical research. An image library would complement NLM's existing bibliographic and factual database services and would ideally be available through the same computer networks as are these current NLM services. Early in 1989, NLM's Board of Regents convened an ad hoc planning panel to explore possible roles for the NLM in the area of electronic image libraries. In its report to the Board of Regents, the NLM Planning Panel on Electronic Image Libraries recommended that 'NLM should undertake a first project building a digital image library of volumetric data representing a complete, normal adult male and female. This Visible Human Project will include digitized photographic images for cryosectioning, digital images derived from computerized tomography, and digital magnetic resonance images of cadavers.' The technologies needed to support digital high resolution image libraries, including rapid development; and that NLM encourage investigator-initiated research into methods for representing and linking spatial and textual information, structural informatics. The first part of the Visible Human Project is the acquisition of cross-sectional CT and MRI digital images and cross-sectional cryosectional photographic images of a representative male and female cadaver at an average of one millimeter intervals. The corresponding cross-sections in each of the three modalities are to be registerable with one another.
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Shearer, C. K.; Eppler, D.; Farrell, W.; Gruener, J.; Lawrence, S.; Pellis, N.; Spudis, P. D.; Stopar, J.; Zeigler, R.; Neal, C;
2016-01-01
The Lunar Exploration Analysis Group (LEAG) was tasked by the Human Exploration Operations Mission Directorate (HEOMD) to establish a Specific Action Team (SAT) to review lunar Strategic Knowledge Gaps (SKGs) within the context of new lunar data and some specific human mission scenarios. Within this review, the SAT was to identify the SKGs that have been fully or partially retired, identify new SKGs resulting from new data and observations, and review quantitative descriptions of measurements that are required to fill knowledge gaps, the fidelity of the measurements needed, and if relevant, provide examples of existing instruments or potential missions capable of filling the SKGs.
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ISRU in the Context of Future European Human Mars Exploration
Baker, A. M.; Tomatis, C.
2002-01-01
ISRU or In-Situ Resource Utilisation is the use of Martian resources to manufacture, typically, life support consumables (e.g. water, oxygen, breathing buffer gases), and propellant for a return journey to Earth. European studies have shown that some 4kg of reaction mass must be launched to LEO to send 1kg payload to Mars orbit, with landing on the Mars surface reducing payload mass still further. This results in very high transportation costs to Mars, and still higher costs for returning payloads to Earth. There is therefore a major incentive to reduce payload mass for any form of Mars return mission (human or otherwise) by generating consumables on the surface. ESA through its GSTP programme has been investigating the system level design of a number of mission elements as potential European contributions to an international human Mars exploration mission intended for the 2020-2030 timeframe. One of these is an ISRU plant, a small chemical factory to convert feedstock brought from Earth (hydrogen), and Martian atmospheric gases (CO2 and trace quantities of nitrogen and argon) into methane and oxygen propellant for Earth return and life support consumables, in advance of the arrival of astronauts. ISRU technology has been the subject of much investigation around the world, but little detailed research or system level studies have been reported in Europe. Furthermore, the potential applicability of European expertise, technology and sub- system studies to Martian ISRU is not well quantified. Study work covered in this paper has compared existing designs (e.g. NASA's Design Reference Mission, DLR and Mars Society studies) with the latest ESA derived requirements for human Mars exploration, and has generated a system level ISRU design. This paper will review and quantify the baseline chemical reactions essential for ISRU, including CO2 collection and purification, Sabatier reduction of CO2 with hydrogen to methane and water, and electrolysis of water in the context of
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Human Health Countermeasures (HHC) Element Management Plan: Human Research Program. Revision B
Norsk, Peter; Baumann, David
2012-01-01
NASA s Human Research Program (HRP) is an applied research and technology program within the Human Exploration and Operations Mission Directorate (HEOMD) that addresses human health and performance risk mitigation strategies in support of exploration missions. The HRP research and technology development is focused on the highest priority risks to crew health and safety with the goal of ensuring mission success and maintaining long-term crew health. Crew health and performance standards, defined by the NASA Chief Health and Medical Officer (CHMO), set the acceptable risk level for exploration missions. The HRP conducts research to inform these standards as well as provide deliverables, such as countermeasures, that ensure standards can be met to maximize human performance and mission success. The Human Health Countermeasures (HHC) Element was formed as part of the HRP to develop a scientifically-based, integrated approach to understanding and mitigating the health risks associated with human spaceflight. These health risks have been organized into four research portfolios that group similar or related risks. A fifth portfolio exists for managing technology developments and infrastructure projects. The HHC Element portfolios consist of: a) Vision and Cardiovascular; b) Exercise and Performance; c) Multisystem; d) Bone; and e) Technology and Infrastructure. The HHC identifies gaps associated with the health risks and plans human physiology research that will result in knowledge required to more fully understand risks and will result in validated countermeasures to mitigate risks.
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Medical Data Architecture Project Status
Krihak, M.; Middour, C.; Gurram, M.; Wolfe, S.; Marker, N.; Winther, S.; Ronzano, K.; Bolles, D.; Toscano, W.; Shaw, T.
2018-01-01
The Medical Data Architecture (MDA) project supports the Exploration Medical Capability (ExMC) risk to minimize or reduce the risk of adverse health outcomes and decrements in performance due to in-flight medical capabilities on human exploration missions. To mitigate this risk, the ExMC MDA project addresses the technical limitations identified in ExMC Gap Med 07: We do not have the capability to comprehensively process medically-relevant information to support medical operations during exploration missions. This gap identifies that the current in-flight medical data management includes a combination of data collection and distribution methods that are minimally integrated with on-board medical devices and systems. Furthermore, there are a variety of data sources and methods of data collection. For an exploration mission, the seamless management of such data will enable a more medically autonomous crew than the current paradigm. The medical system requirements are being developed in parallel with the exploration mission architecture and vehicle design. ExMC has recognized that in order to make informed decisions about a medical data architecture framework, current methods for medical data management must not only be understood, but an architecture must also be identified that provides the crew with actionable insight to medical conditions. This medical data architecture will provide the necessary functionality to address the challenges of executing a self-contained medical system that approaches crew health care delivery without assistance from ground support. Hence, the products supported by current prototype development will directly inform exploration medical system requirements.
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From Moral Facts to Human Finitude
DEFF Research Database (Denmark)
Dyring, Rasmus
2018-01-01
The ethical turn in anthropology was to a large extent premised on a decisive break with Durkheimian “unfreedom.” This essay explores the theoretical condition in which this break has left the project of describing ethnographically the possibilities of human freedom. The essay explicates some amb...
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High Accuracy Human Activity Recognition Based on Sparse Locality Preserving Projections.
Zhu, Xiangbin; Qiu, Huiling
2016-01-01
Human activity recognition(HAR) from the temporal streams of sensory data has been applied to many fields, such as healthcare services, intelligent environments and cyber security. However, the classification accuracy of most existed methods is not enough in some applications, especially for healthcare services. In order to improving accuracy, it is necessary to develop a novel method which will take full account of the intrinsic sequential characteristics for time-series sensory data. Moreover, each human activity may has correlated feature relationship at different levels. Therefore, in this paper, we propose a three-stage continuous hidden Markov model (TSCHMM) approach to recognize human activities. The proposed method contains coarse, fine and accurate classification. The feature reduction is an important step in classification processing. In this paper, sparse locality preserving projections (SpLPP) is exploited to determine the optimal feature subsets for accurate classification of the stationary-activity data. It can extract more discriminative activities features from the sensor data compared with locality preserving projections. Furthermore, all of the gyro-based features are used for accurate classification of the moving data. Compared with other methods, our method uses significantly less number of features, and the over-all accuracy has been obviously improved.
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High Accuracy Human Activity Recognition Based on Sparse Locality Preserving Projections.
Directory of Open Access Journals (Sweden)
Xiangbin Zhu
Full Text Available Human activity recognition(HAR from the temporal streams of sensory data has been applied to many fields, such as healthcare services, intelligent environments and cyber security. However, the classification accuracy of most existed methods is not enough in some applications, especially for healthcare services. In order to improving accuracy, it is necessary to develop a novel method which will take full account of the intrinsic sequential characteristics for time-series sensory data. Moreover, each human activity may has correlated feature relationship at different levels. Therefore, in this paper, we propose a three-stage continuous hidden Markov model (TSCHMM approach to recognize human activities. The proposed method contains coarse, fine and accurate classification. The feature reduction is an important step in classification processing. In this paper, sparse locality preserving projections (SpLPP is exploited to determine the optimal feature subsets for accurate classification of the stationary-activity data. It can extract more discriminative activities features from the sensor data compared with locality preserving projections. Furthermore, all of the gyro-based features are used for accurate classification of the moving data. Compared with other methods, our method uses significantly less number of features, and the over-all accuracy has been obviously improved.
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Knowledge Governance Strategies in Project-based Organizations
DEFF Research Database (Denmark)
Pemsel, Sofia; Müller, Ralf; Söderlund, Jonas
2016-01-01
Knowledge governance (KG) aims at strategically influencing knowledge processes by implementing governance mechanisms. Little is known about whether, how, or why such strategies differ among firms. We utilize a large-scale empirical study of 20 organizations to develop a typology of KG strategies...... in project-based organizations; we then explore how these strategies emerge and affect organizational knowledge processes. Six strategies are identified: Protector, Deliverer, Polisher, Explorer, Supporter, and Analyzer. This paper posits a multi-level categorization model to facilitate comparisons among KG...... strategies. We uncover three main drivers of organizations' chosen knowledge governance strategies-namely, attitudes about humans, knowledge, and knowledge control....
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Thronson, Harley A.; Baker, John; Beaty, David; Carberry, Chris; Craig, Mark; Davis, Richard M.; Drake, Bret G.; Cassady, Joseph; Hays, Lindsay; Hoffman, Stephen J.;
2016-01-01
To continue to build broadly based consensus on the future of human space exploration, the Fourth Community Workshop on Achievability and Sustainability of Human Exploration of Mars (AM IV), organized by Explore Mars, Inc. and the American Astronautical Society, was held at the Double Tree Inn in Monrovia, CA., December 68, 2016. Approximately 60 invited professionals from the industrial and commercial sectors, academia, and NASA, along with international colleagues, participated in the workshop. These individuals were chosen to be representative of the breadth of interests in astronaut and robotic Mars exploration.
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Clinton, R. G., Jr.
2014-01-01
NASA, including each Mission Directorate, is investing in, experimenting with, and/or utilizing AM across a broad spectrum of applications and projects; Centers have created and are continuing to create partnerships with industry, other Government Agencies, other Centers, and Universities; In-house additive manufacturing capability enables rapid iteration of the entire design, development and testing process, increasing innovation and reducing risk and cost to projects; For deep space exploration, AM offers significant reduction to logistics costs and risk by providing ability to create on demand; There are challenges: Overwhelming message from recent JANNAF AM for Propulsion Applications TIM was "certification."; NASA will continue to work with our partners to address this and other challenges to advance the state of the art in AM and incorporate these capabilities into an array of applications from aerospace to science missions to deep space exploration.
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Final report on the Project Research 'Assessment of Human Exposure to Environmental Radiation'
International Nuclear Information System (INIS)
1989-03-01
This is the final report of the Project Research, 'Assessment of Human Exposure to Environmental Radiation', which has been conducted during the period 1983-1988. With the objective of assessing risk of environmental radioactivity to the population, the Project was divided into the following five research groups: (1) research for establishing calculation models and parameters in transfer of radionuclides from crop species through the human body; (2) research for analyzing transfer of radionuclides in the ocean and their contributions to exposure doses in the human body; (3) research for surveying accuracy of exposure models for the external body and respiratory organ and the influential factors; (4) research for determining uptake and biokinetics of radionuclides in the body; and (5) research for estimating and evaluating physical and physiological characteristics of reference Japanese man and the populaltion doses. Effluents from nuclear power plants and reprocessing plants were regarded as radionuclide sources in the water and atmosphere. (N.K.)
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The UK Human Genome Mapping Project online computing service.
Rysavy, F R; Bishop, M J; Gibbs, G P; Williams, G W
1992-04-01
This paper presents an overview of computing and networking facilities developed by the Medical Research Council to provide online computing support to the Human Genome Mapping Project (HGMP) in the UK. The facility is connected to a number of other computing facilities in various centres of genetics and molecular biology research excellence, either directly via high-speed links or through national and international wide-area networks. The paper describes the design and implementation of the current system, a 'client/server' network of Sun, IBM, DEC and Apple servers, gateways and workstations. A short outline of online computing services currently delivered by this system to the UK human genetics research community is also provided. More information about the services and their availability could be obtained by a direct approach to the UK HGMP-RC.
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Salerno, Theresa A.
2009-01-01
A multiplex allele-specific PCR analysis was developed to identify six "common" genotypes: AA, AO, BB, BO, OO, and AB. This project included a pre-laboratory exercise that provided active learning experiences and developed critical thinking skills. This laboratory resulted in many successful analyses, which were verified by student knowledge of…
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Chu, Joanna T W; Chan, Sophia S; Stewart, Sunita M; Zhou, Qianling; Leung, Charles Sai-Cheong; Wan, Alice; Lam, Tai Hing
2017-01-01
Community engagement is a powerful tool in bringing about positive social and community change. Community stakeholders possess critical experience and knowledge that are needed to inform the development of community-based projects. However, limited literature is available on the practical experience involved with planning and implementing community-based family programs. Even less has been published documenting efforts in Chinese communities. This paper explores community stakeholders' experiences with the enhancing family well-being project-part of a citywide project entitled the "FAMILY Project," aimed at promoting family health, happiness, and harmony in Hong Kong. This qualitative evaluation examined the perspectives of community stakeholders. Four focus groups with social workers ( n = 24) and six in-depth interviews with steering committee members were conducted from December 2012 to May 2013 in Hong Kong. Focus groups and in-depths interview were audiotaped, transcribed, and analyzed using thematic analysis techniques. Rich accounts were given by our respondents on various aspects of the project. Main themes and subthemes were identified and grouped into four categories (project conception, project implementation, project consolidation, and the overall impact of the project). Respondents described the practical challenges associated with the project (e.g., recruitment, balancing scientific research, and lack of resources) and identified the elements that are important to the success of the project. These included the commitment to a shared goal, multi-agency collaboration, and a platform for knowledge exchange. Finally, respondents perceived benefits of the project at both the individual and community level. Our project sheds light on many of the practical considerations and challenges associated with a designing and implementing a community-based family intervention project. Community stakeholders input provided important information on their perceived
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The human genome: Some assembly required. Final report
Energy Technology Data Exchange (ETDEWEB)
NONE
1994-12-31
The Human Genome Project promises to be one of the most rewarding endeavors in modern biology. The cost and the ethical and social implications, however, have made this project the source of considerable debate both in the scientific community and in the public at large. The 1994 Graduate Student Symposium addresses the scientific merits of the project, the technical issues involved in accomplishing the task, as well as the medical and social issues which stem from the wealth of knowledge which the Human Genome Project will help create. To this end, speakers were brought together who represent the diverse areas of expertise characteristic of this multidisciplinary project. The keynote speaker addresses the project`s motivations and goals in the larger context of biological and medical sciences. The first two sessions address relevant technical issues, data collection with a focus on high-throughput sequencing methods and data analysis with an emphasis on identification of coding sequences. The third session explores recent advances in the understanding of genetic diseases and possible routes to treatment. Finally, the last session addresses some of the ethical, social and legal issues which will undoubtedly arise from having a detailed knowledge of the human genome.
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Exploring delay causes of road construction projects in
Directory of Open Access Journals (Sweden)
Remon F. Aziz
2016-06-01
Full Text Available Construction delays are a common phenomenon in civil engineering projects in Egypt including road construction projects. Therefore, it is essential to study and analyze causes of road construction delays. This paper studied a list of construction delay causes gathered from literature having different types of construction, different countries, different periods and different numbers of delay causes and delay groups. A questionnaire and personal interviews have formed the basis of this paper listing 293 delay causes. The questionnaire survey was distributed to 500 construction participants and 389 were received who represent consultants, contractors and site/design engineers excluding the owner representing the government in road projects as one party only. Relative Importance Index (RII is calculated and according to the highest values the top twenty and the least twenty delay causes of construction projects in Egypt are determined. A case study is analyzed and compared to the most important delay causes in the paper. The test results reveal good correlation of causes and groups between contractors and site/design engineers and between consultants and site design engineers and a somewhat low correlation between contractors and consultants. So there are no root causes that can be taking for granted to be most or least effective delay causes. Proposed model for predicting actual road construction project duration was developed; a real case study tested the accuracy of proposed model. According to the analysis of case study, the most contributing causes and groups to delays were discussed, and some future recommendations were proposed in order to control and minimize delays in road construction projects. These findings can be helpful for project managers to mitigate the road construction delays in Egypt. In order to effectively overcome the road construction delays in developing countries, suggestions are made for fundamental and large
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The Danish contribution to the European DEMOCOPHES project
DEFF Research Database (Denmark)
Mørck, Thit A; Nielsen, Flemming; Nielsen, Jeanette K S
2015-01-01
Human biomonitoring (HBM) is an important tool, increasingly used for measuring true levels of the body burdens of environmental chemicals in the general population. In Europe, a harmonized HBM program was needed to open the possibility to compare levels across borders. To explore the prospect...... of a harmonized European HBM project, DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) was completed in 17 European countries. The basic measurements performed in all implemented countries of DEMOCOPHES included cadmium, cotinine and phthalate metabolites...... in mothers and an association between cadmium and cotinine was also found. As expected high cotinine levels were found in smoking mothers. For both mercury and cadmium significantly higher concentrations were found in the mothers compared to their children. In Denmark, the DEMOCOPHES project was co...
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Exploring the human body space: A geographical information system based anatomical atlas
Directory of Open Access Journals (Sweden)
Antonio Barbeito
2016-06-01
Full Text Available Anatomical atlases allow mapping the anatomical structures of the human body. Early versions of these systems consisted of analogical representations with informative text and labeled images of the human body. With computer systems, digital versions emerged and the third and fourth dimensions were introduced. Consequently, these systems increased their efficiency, allowing more realistic visualizations with improved interactivity and functionality. The 4D atlases allow modeling changes over time on the structures represented. The anatomical atlases based on geographic information system (GIS environments allow the creation of platforms with a high degree of interactivity and new tools to explore and analyze the human body. In this study we expand the functions of a human body representation system by creating new vector data, topology, functions, and an improved user interface. The new prototype emulates a 3D GIS with a topological model of the human body, replicates the information provided by anatomical atlases, and provides a higher level of functionality and interactivity. At this stage, the developed system is intended to be used as an educational tool and integrates into the same interface the typical representations of surface and sectional atlases.
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Human errors in test and maintenance of nuclear power plants. Nordic project work
International Nuclear Information System (INIS)
Andersson, H.; Liwaang, B.
1985-08-01
The present report is a summary of the NKA/LIT-1 project performed for the period 1981-1985. The report summarizes work on human error influence in test and calibration activities in nuclear power plants, reviews problems regarding optimization of the test intervals, organization of test and maintenance activities, and the analysis of human error contribution to the overall risk in test and mainenace tasks. (author)
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Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project.
Omenn, Gilbert S; Lane, Lydie; Lundberg, Emma K; Overall, Christopher M; Deutsch, Eric W
2017-12-01
The Human Proteome Organization (HUPO) Human Proteome Project (HPP) continues to make progress on its two overall goals: (1) completing the protein parts list, with an annual update of the HUPO draft human proteome, and (2) making proteomics an integrated complement to genomics and transcriptomics throughout biomedical and life sciences research. neXtProt version 2017-01-23 has 17 008 confident protein identifications (Protein Existence [PE] level 1) that are compliant with the HPP Guidelines v2.1 ( https://hupo.org/Guidelines ), up from 13 664 in 2012-12 and 16 518 in 2016-04. Remaining to be found by mass spectrometry and other methods are 2579 "missing proteins" (PE2+3+4), down from 2949 in 2016. PeptideAtlas 2017-01 has 15 173 canonical proteins, accounting for nearly all of the 15 290 PE1 proteins based on MS data. These resources have extensive data on PTMs, single amino acid variants, and splice isoforms. The Human Protein Atlas v16 has 10 492 highly curated protein entries with tissue and subcellular spatial localization of proteins and transcript expression. Organ-specific popular protein lists have been generated for broad use in quantitative targeted proteomics using SRM-MS or DIA-SWATH-MS studies of biology and disease.
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Getting the Word Out on the Human Genome Project: A Course for Physicians
Energy Technology Data Exchange (ETDEWEB)
Sara L. Tobin
2004-09-29
Our project, ''Getting the Word Out on the Human Genome Project: A Course for Physicians,'' presented educational goals to convey the power and promise of the Human Genome Program to a variety of professional, educational, and public audiences. Our initial goal was to provide practicing physicians with a comprehensive multimedia tool to update their skills in the genomic era. We therefore created the multimedia courseware, ''The New Genetics: Courseware for Physicians. Molecular Concepts, Applications, and Ramifications.'' However, as the project moved forward, several unanticipated audiences found the courseware to be useful for instruction and for self-education, so an additional edition of the courseware ''The New Genetics: Medicine and the Human Genome. Molecular Concepts, Applications, and Ramifications'' was published simultaneously with the physician version. At the time that both versions of the courseware were being completed, Stanford's Office of Technology Licensing opted not to commercialize the courseware and offered a license-back agreement if the authors founded a commercial business. The authors thus became closely involved in marketing and sales, and several thousand copies of the courseware have been sold. Surprisingly, the non-physician version has turned out to be more in demand, and this has led us in several new directions, most of which involve undergraduate education. These are discussed in detail in the Report.
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A LARGE HUMAN CENTRIFUGE FOR EXPLORATION AND EXPLOITATION RESEARCH
Directory of Open Access Journals (Sweden)
Jack J.W.A. van Loon
2012-06-01
Full Text Available This paper addresses concepts regarding the development of an Altered Gravity Platform (AGP that will serve as a research platform for human space exploration. Space flight causes a multitude of physiological problems, many of which are due to gravity level transitions. Going from Earth's gravity to microgravity generates fluid shifts, space motion sickness, cardiovascular deconditioning among other changes, and returning to a gravity environment again puts the astronauts under similar stressors. A prolonged stay in microgravity provokes additional deleterious changes such as bone loss, muscle atrophy and loss of coordination or specific psychological stresses. To prepare for future manned space exploration missions, a ground-based research test bed for validating countermeasures against the deleterious effects of g-level transitions is needed. The proposed AGP is a large rotating facility (diameter > 150 m, where gravity levels ranging from 1.1 to 1.5g are generated, covering short episodes or during prolonged stays of weeks or even months. On this platform, facilities are built where a crew of 6 to 8 humans can live autonomously. Adaptation from 1 g to higher g levels can be studied extensively and monitored continuously. Similarly, re-adaptation back to 1 g, after a prolonged period of altered g can also be investigated. Study of the physiological and psychological adaptation to changing g-levels will provide instrumental and predictive knowledge to better define the ultimate countermeasures that are needed for future successful manned space exploration missions to the Moon, Mars and elsewhere. The AGP initiative will allow scientific top experts in Europe and worldwide to investigate the necessary scientific, operational, and engineering inputs required for such space missions. Because so many different physiological systems are involved in adaptation to gravity levels, a multidisciplinary approach is crucial. One of the final and crucial
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Navani, Sanjay
2016-04-01
The Human Protein Atlas (HPA) program (www.proteinatlas.org) is an international program that has been set up to allow for a systematic exploration of the human proteome using antibody-based proteomics. This is accomplished by combining high-throughput generation of affinity-purified (mono-specific) antibodies with protein profiling in a multitude of tissues/cell types assembled in tissue microarrays. Twenty-six surgical pathologists over a seven-and-half year period have annotated and curated approximately sixteen million tissue images derived from immunostaining of normal and cancer tissues by approximately 23 000 antibodies. Web-based annotation software that allows for a basic and rapid evaluation of immunoreactivity in tissues has been utilized. Intensity, fraction of immunoreactive cells and subcellular localization were recorded for each given cell population. A text comment summarizing the characteristics for each antibody was added. The methods used and the challenges encountered for this exercise, the largest effort ever by a single group of surgical pathologists, are discussed. Manual annotation of digital images is an important tool that may be successfully utilized in high-throughput research projects. This is the first time an Indian private pathology laboratory has been associated with cutting-edge research internationally providing a classic example of developed and emerging nation collaboration. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Exploring the Human Ecology of the Younger Dryas Extraterrestrial Impact Event
Kennett, D. J.; Erlandson, J. M.; Braje, T. J.; Culleton, B. J.
2007-05-01
Several lines of evidence now exist for a major extraterrestrial impact event in North America at 12.9 ka (the YDB). This impact partially destabilized the Laurentide and Cordilleran ice sheets, triggered abrupt Younger Dryas cooling and extensive wildfires, and contributed to megafaunal extinction. This event also occurred soon after the well established colonization of the Americas by anatomically modern humans. Confirmation of this event would represent the first near-time extraterrestrial impact with significant effects on human populations. These likely included widespread, abrupt human mortality, population displacement, migration into less effected or newly established habitats, loss of cultural traditions, and resource diversification in the face of the massive megafaunal extinction and population reductions in surviving animal populations. Ultimately, these transformations established the context for the special character of plant and animal domestication and the emergence of agricultural economies in North America. We explore the Late Pleistocene archaeological record in North America within the context of documented major biotic changes associated with the YDB in North America and of the massive ecological affects hypothesized for this event.
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Human and Robotic Exploration Missions to Phobos Prior to Crewed Mars Surface Missions
Gernhardt, Michael L.; Chappell, Steven P.; Bekdash, Omar S.; Abercromby, Andrew F.
2016-01-01
Phobos is a scientifically significant destination that would facilitate the development and operation of the human Mars transportation infrastructure, unmanned cargo delivery systems and other Mars surface systems. In addition to developing systems relevant to Mars surface missions, Phobos offers engineering, operational, and public engagement opportunities that could enhance subsequent Mars surface operations. These opportunities include the use of low latency teleoperations to control Mars surface assets associated with exploration science, human landing-site selection and infrastructure development which may include in situ resource utilization (ISRU) to provide liquid oxygen for the Mars Ascent Vehicle (MAV). A human mission to Mars' moons would be preceded by a cargo predeploy of a surface habitat and a pressurized excursion vehicle (PEV) to Mars orbit. Once in Mars orbit, the habitat and PEV would spiral to Phobos using solar electric propulsion based systems, with the habitat descending to the surface and the PEV remaining in orbit. When a crewed mission is launched to Phobos, it would include the remaining systems to support the crew during the Earth-Mars transit and to reach Phobos after insertion in to Mars orbit. The crew would taxi from Mars orbit to Phobos to join with the predeployed systems in a spacecraft that is based on a MAV, dock with and transfer to the PEV in Phobos orbit, and descend in the PEV to the surface habitat. A static Phobos surface habitat was chosen as a baseline architecture, in combination with the PEV that was used to descend from orbit as the main exploration vehicle. The habitat would, however, have limited capability to relocate on the surface to shorten excursion distances required by the PEV during exploration and to provide rescue capability should the PEV become disabled. To supplement exploration capabilities of the PEV, the surface habitat would utilize deployable EVA support structures that allow astronauts to work
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neXtProt: organizing protein knowledge in the context of human proteome projects.
Gaudet, Pascale; Argoud-Puy, Ghislaine; Cusin, Isabelle; Duek, Paula; Evalet, Olivier; Gateau, Alain; Gleizes, Anne; Pereira, Mario; Zahn-Zabal, Monique; Zwahlen, Catherine; Bairoch, Amos; Lane, Lydie
2013-01-04
About 5000 (25%) of the ~20400 human protein-coding genes currently lack any experimental evidence at the protein level. For many others, there is only little information relative to their abundance, distribution, subcellular localization, interactions, or cellular functions. The aim of the HUPO Human Proteome Project (HPP, www.thehpp.org ) is to collect this information for every human protein. HPP is based on three major pillars: mass spectrometry (MS), antibody/affinity capture reagents (Ab), and bioinformatics-driven knowledge base (KB). To meet this objective, the Chromosome-Centric Human Proteome Project (C-HPP) proposes to build this catalog chromosome-by-chromosome ( www.c-hpp.org ) by focusing primarily on proteins that currently lack MS evidence or Ab detection. These are termed "missing proteins" by the HPP consortium. The lack of observation of a protein can be due to various factors including incorrect and incomplete gene annotation, low or restricted expression, or instability. neXtProt ( www.nextprot.org ) is a new web-based knowledge platform specific for human proteins that aims to complement UniProtKB/Swiss-Prot ( www.uniprot.org ) with detailed information obtained from carefully selected high-throughput experiments on genomic variation, post-translational modifications, as well as protein expression in tissues and cells. This article describes how neXtProt contributes to prioritize C-HPP efforts and integrates C-HPP results with other research efforts to create a complete human proteome catalog.
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Paul, Svenja
2013-01-01
How do human resource practices strengthen open innovation activities? This inductive study of six cases led to propositions exploring that question. I thereby investigated the role of human resource management in open innovation, specifically the relation between HR practices and an employee's willingness to embrace open innovation.
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Exploring leadership in self-managed project teams in Malaysia
Directory of Open Access Journals (Sweden)
Zaleha Yazid
2015-01-01
Full Text Available This paper focuses on a longitudinal approach in exploring leadership in Self-Managed Project Teams (SMPT. SMPT has been known to contribute to organizations by improving productivity and increasing organizational performance. Therefore, understanding the dynamics of leadership in this type of team can be seen as one of the important factors to ensure the success of organizations. Leading a team which manages itself is a challenge as increased autonomy and control is given to the team which eliminates the existence of a leader. It is important to understand the extent of how the external leader is involved within SMPT and whether the external leader approaches highlighted in the literature are applicable in such a situation and how these approaches change during work processes. This study comprises of evidence collected through semi-structured interviews in two small and medium sized organizations in Malaysia. Weekly telephone interviews as well as face-to-face interviews were conducted which provides contextual data for the research. In this research, the evidence suggested that SMPT transform from self-managed toward leader-managed resulting from several factors, such as conflict handling strategies. Specifically, it was found that avoiding conflicts, rather than confronting, transform the team into being leader dependent.
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Witvliet, M.I.
2013-01-01
Research investigating health and human rights from a socio-epidemiological perspective is emerging. Still there is a noticeable paucity of research that empirically links population health to human rights concerns. In this thesis, three examples relevant to human rights are explored. We investigate
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International Nuclear Information System (INIS)
Clark, J.S.; George, J.A.; Gefert, L.P.; Doherty, M.P.; Sefcik, R.J.
1994-03-01
NASA has completed a preliminary mission and systems study of nuclear electric propulsion (NEP) systems for 'split-sprint' human exploration and related robotic cargo missions to Mars. This paper describes the study, the mission architecture selected, the NEP system and technology development needs, proposed development schedules, and estimated development costs. Since current administration policy makers have delayed funding for key technology development activities that could make Mars exploration missions a reality in the near future, NASA will have time to evaluate various alternate mission options, and it appears prudent to ensure that Mars mission plans focus on astronaut and mission safety, while reducing costs to acceptable levels. The split-sprint nuclear electric propulsion system offers trip times comparable to nuclear thermal propulsion (NTP) systems, while providing mission abort opportunities that are not possible with 'reference' mission architectures. Thus, NEP systems offer short transit times for the astronauts, reducing the exposure of the crew to intergalactic cosmic radiation. The high specific impulse of the NEP system, which leads to very low propellant requirements, results in significantly lower 'initial mass in low earth orbit' (IMLEO). Launch vehicle packaging studies show that the NEP system can be launched, assembled, and deployed, with about one less 240-metric-ton heavy lift launch vehicle (HLLV) per mission opportunity - a very Technology development cost of the nuclear reactor for an NEP system would be shared with the proposed nuclear surface power systems, since nuclear systems will be required to provide substantial electrical power on the surface of Mars. The NEP development project plan proposed includes evolutionary technology development for nuclear electric propulsion systems that expands upon SP-100 (Space Power - 100 kw(e)) technology that has been developed for lunar and Mars surface nuclear power
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Cosmic Humanity: Utopia, Realities, Prospects
Directory of Open Access Journals (Sweden)
Sergey Krichevsky
2017-07-01
Full Text Available The philosophical foundations of the theory and practice of the creation of cosmic humanity as a process of the evolution of human civilization, the emergence into space, with the prospect of resettlement outside the Earth are considered. There is a connection between myths, fantasies, ideas, concepts and projects aimed at the exploration of outer space, the creation of cosmic humanity. A new and voluminous definition of cosmic humanity in the evolutionary paradigm is given. Cosmic humanity is (essence and 4 stages of evolution: 1. Humanity living on Earth, sensing, knowing, understanding its cosmic origin, relationship with the cosmos and cosmic destiny. 2. Humanity living on Earth, leading aerospace activity for the purposes of exploration and use of aerospace space (Heaven, Space for survival and development. 3. Humanity living on Earth and outside the Earth — in the solar system, preserving the Earth and mastering the Cosmos for survival and development. 4. Humanity, settled and living in the Cosmos. Now humanity is in the process of transition from the second to the third stage. In the process of this evolution, a complex transformation of man and society takes place. The problem-semantic field of cosmic humanity is described and its general model is presented. The meta-goal-setting is the justification of cosmic humanity with the application of the anthropic principle and its “active” super (post anthropic supplement: “Cosmic humanity has an evolutionary purpose to actively manage evolution: change man, humanity and the universe.” The evolution of the “cosmic dream”, goals and technologies of space activities is formalized in the form of a conceptual model. Challenges and negative trends are considered in connection with the crisis of space activity, criticism and attempts to limit the flights of people into space. The prototype of cosmic humanity, its basis and acting model is the cosmonauts’ community. The main
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Applicability of neutrino beams to Earth exploration
International Nuclear Information System (INIS)
Dolgoshein, B.A.; Kalinovskij, A.N.
1985-01-01
The projects on applicability of neutrino beams from high energy accelerators for geological exploration and study of the Earth structure are discussed. The GENIUS (Geological Exploration by Neutrino Induced Underground Sound) project is among them. It covers detecting and studying space-time characteristics of acoustic signal arising in case of neutrino interaction with Earth depth rocks discussed. The GEMINI (Geological Exploration with Muons Induced by neutrino interactions) project represents one more possibility for using geotron neutrino beam for the purpose of geological exploration. The GEOSCAN project represents the possibility for applying high energy neutrino beams for the purpose of the Earth translusence to determine the changes in the density of internal part of the Earth. The necessity of detailed investigations of the problem of applicability of neutrino beams in the field of the Earth exploration is pointed out
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Orlecka-Sikora, Beata; Lasocki, Stanislaw; Staszek, Monika; Olszewska, Dorota; Urban, Pawel; Jaroslawski, Janusz; Cielesta, Szymon; Mirek, Janusz; Wiszniowski, Jan; Picozzi, Matteo; Solaro, Giuseppe; Pringle, Jamie; Toon, Sam; Cesca, Simone; Kuehn, Daniela; Ruigrok, Elmer; Gunning, Andrew; Isherwood, Catherine
2017-04-01
The main objective of the "Shale gas exploration and exploitation induced risks - SHEER" project (Horizon 2020, call LCE 16-2014) is to develop a probabilistic methodology to assess and mitigate the short- and the long-term environmental risks associated with the exploration and exploitation of shale gas. To this end, the SHEER project makes use of a large amount of heterogeneous data of various types. This data, from different disciplines of science e.g. geophysical, geochemical, geological, technological, etc., must be homogenized, harmonized and made accessible exclusively for all project participants. This requires to develop an over-arching structure for high-level multidisciplinary data integration. The bespoke solution is provided by Thematic Core Service Anthropogenic Hazards (TCS AH) developed in the framework of European Plate Observing System Program (https://tcs.ah-epos.eu/, infrastructural projects IS-EPOS, POIG.02.03.00-14-090/13-00 and EPOS IP, H2020-INFRADEV-1-2015-1). TCS AH provides virtual access to a comprehensive, wide-scale and high quality research infrastructure in the field of induced seismicity and other anthropogenic hazards evoked by exploration and exploitation of geo-resources. TCS AH is designed as a functional e-research environment to ensure a researcher the maximum possible freedom for experimentation by providing a virtual laboratory flexible to create own workspace for processing streams. A data-management process promotes the use of research infrastructure in novel ways providing an access to (i) data gathered in the so-called "episodes", comprehensively describing a geophysical process, induced or triggered by human technological activity, which under certain circumstances can become hazardous for people, infrastructure and the environment, (ii) problem-oriented, specific services, with the particular attention devoted to methods analyzing correlations between technology, geophysical response and resulting hazards, (iii) the
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Distributed and grid computing projects with research focus in human health.
Diomidous, Marianna; Zikos, Dimitrios
2012-01-01
Distributed systems and grid computing systems are used to connect several computers to obtain a higher level of performance, in order to solve a problem. During the last decade, projects use the World Wide Web to aggregate individuals' CPU power for research purposes. This paper presents the existing active large scale distributed and grid computing projects with research focus in human health. There have been found and presented 11 active projects with more than 2000 Processing Units (PUs) each. The research focus for most of them is molecular biology and, specifically on understanding or predicting protein structure through simulation, comparing proteins, genomic analysis for disease provoking genes and drug design. Though not in all cases explicitly stated, common target diseases include research to find cure against HIV, dengue, Duchene dystrophy, Parkinson's disease, various types of cancer and influenza. Other diseases include malaria, anthrax, Alzheimer's disease. The need for national initiatives and European Collaboration for larger scale projects is stressed, to raise the awareness of citizens to participate in order to create a culture of internet volunteering altruism.
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Parker, L.; Minow, J.; Pulkkinen, A.; Fry, D.; Semones, E.; Allen, J.; St Cyr, C.; Mertens, C.; Jun, I.; Onsager, T.; Hock, R.
2018-02-01
NASA's Engineering and Space Center (NESC) is conducting an independent technical assessment of space environment monitoring and forecasting architecture options to support human and robotic deep space exploration.
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Sagan, Carl
1991-01-01
The proposed Space Exploration Initiative (SDI) to launch a manned flight to Mars is examined in the current light of growing constraints in costs and other human requirements. Sharing the huge costs of such a program among a group of nations might become low enough for the project to be feasible. Robotic missions, equipped with enhanced artificial intelligence, appear to be capable of satisfying mission requirements at 10 percent or less, of the cost of a manned flight. Various additional pros and cons are discussed regarding both SDI generally and a Mars mission. It is suggested that R&D projects be pursued that can be better justified and can also contribute to human mission to Mars if eventually a decision to go is made.
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Deng, Rong; Iyer, Suhasini; Theil, Frank-Peter; Mortensen, Deborah L; Fielder, Paul J; Prabhu, Saileta
2011-01-01
The pharmacokinetics (PK) of therapeutic antibodies is determined by target and non-target mediated mechanisms. These antibody-specific factors need to be considered during prediction of human PK based upon preclinical information. Principles of allometric scaling established for small molecules using data from multiple animal species cannot be directly applied to antibodies. Here, different methods for projecting human clearance (CL) from animal PK data for 13 therapeutic monoclonal antibodi...
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Innocenti, Giorgio M; Dyrby, Tim B; Andersen, Kasper Winther; Rouiller, Eric M; Caminiti, Roberto
2017-06-01
The corpus callosum establishes the anatomical continuity between the 2 hemispheres and coordinates their activity. Using histological tracing, single axon reconstructions, and diffusion tractography, we describe a callosal projection to n caudatus and putamen in monkeys and humans. In both species, the origin of this projection is more restricted than that of the ipsilateral projection. In monkeys, it consists of thin axons (0.4-0.6 µm), appropriate for spatial and temporal dispersion of subliminal inputs. For prefrontal cortex, contralateral minus ipsilateral delays to striatum calculated from axon diameters and conduction distance are <2 ms in the monkey and, by extrapolation, <4 ms in humans. This delay corresponds to the performance in Poffenberger's paradigm, a classical attempt to estimate central conduction delays, with a neuropsychological task. In both species, callosal cortico-striatal projections originate from prefrontal, premotor, and motor areas. In humans, we discovered a new projection originating from superior parietal lobule, supramarginal, and superior temporal gyrus, regions engaged in language processing. This projection crosses in the isthmus the lesion of which was reported to dissociate syntax and prosody. The projection might originate from an overproduction of callosal projections in development, differentially pruned depending on species. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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Scientific field training for human planetary exploration
Lim, D. S. S.; Warman, G. L.; Gernhardt, M. L.; McKay, C. P.; Fong, T.; Marinova, M. M.; Davila, A. F.; Andersen, D.; Brady, A. L.; Cardman, Z.; Cowie, B.; Delaney, M. D.; Fairén, A. G.; Forrest, A. L.; Heaton, J.; Laval, B. E.; Arnold, R.; Nuytten, P.; Osinski, G.; Reay, M.; Reid, D.; Schulze-Makuch, D.; Shepard, R.; Slater, G. F.; Williams, D.
2010-05-01
Forthcoming human planetary exploration will require increased scientific return (both in real time and post-mission), longer surface stays, greater geographical coverage, longer and more frequent EVAs, and more operational complexities than during the Apollo missions. As such, there is a need to shift the nature of astronauts' scientific capabilities to something akin to an experienced terrestrial field scientist. To achieve this aim, the authors present a case that astronaut training should include an Apollo-style curriculum based on traditional field school experiences, as well as full immersion in field science programs. Herein we propose four Learning Design Principles (LDPs) focused on optimizing astronaut learning in field science settings. The LDPs are as follows: LDP#1: Provide multiple experiences: varied field science activities will hone astronauts' abilities to adapt to novel scientific opportunities LDP#2: Focus on the learner: fostering intrinsic motivation will orient astronauts towards continuous informal learning and a quest for mastery LDP#3: Provide a relevant experience - the field site: field sites that share features with future planetary missions will increase the likelihood that astronauts will successfully transfer learning LDP#4: Provide a social learning experience - the field science team and their activities: ensuring the field team includes members of varying levels of experience engaged in opportunities for discourse and joint problem solving will facilitate astronauts' abilities to think and perform like a field scientist. The proposed training program focuses on the intellectual and technical aspects of field science, as well as the cognitive manner in which field scientists experience, observe and synthesize their environment. The goal of the latter is to help astronauts develop the thought patterns and mechanics of an effective field scientist, thereby providing a broader base of experience and expertise than could be achieved
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Directory of Open Access Journals (Sweden)
Renato Penha
2012-10-01
Full Text Available A project can be defined as a complex system. This requires the use of resources (human, material, technology, etc., allocated among alternative uses, as a means to achieve specific goals by the presence of constraints of different orders. The planning, allocation and prioritization of resources, including human resource specialists (HRE, is performed by means of single project management.This treatment can cause internal strife by using the same resource or even its underuse, and may worsen in software development environments due to the high degree of interdependence, uncertainty and risk of each project. This need is related to the so called Job Shop Problem (JSP. In this context, the objective of this study is to evaluate the mathematical models of genetic algorithm and optimization and their contributions to solve Job Shop Problem in software development projects with the use of human resources specialists.
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Human and Robotic Mission to Small Bodies: Mapping, Planning and Exploration
Neffian, Ara V.; Bellerose, Julie; Beyer, Ross A.; Archinal, Brent; Edwards, Laurence; Lee, Pascal; Colaprete, Anthony; Fong, Terry
2013-01-01
This study investigates the requirements, performs a gap analysis and makes a set of recommendations for mapping products and exploration tools required to support operations and scientific discovery for near- term and future NASA missions to small bodies. The mapping products and their requirements are based on the analysis of current mission scenarios (rendezvous, docking, and sample return) and recommendations made by the NEA Users Team (NUT) in the framework of human exploration. The mapping products that sat- isfy operational, scienti c, and public outreach goals include topography, images, albedo, gravity, mass, density, subsurface radar, mineralogical and thermal maps. The gap analysis points to a need for incremental generation of mapping products from low (flyby) to high-resolution data needed for anchoring and docking, real-time spatial data processing for hazard avoidance and astronaut or robot localization in low gravity, high dynamic environments, and motivates a standard for coordinate reference systems capable of describing irregular body shapes. Another aspect investigated in this study is the set of requirements and the gap analysis for exploration tools that support visualization and simulation of operational conditions including soil interactions, environment dynamics, and communications coverage. Building robust, usable data sets and visualisation/simulation tools is the best way for mission designers and simulators to make correct decisions for future missions. In the near term, it is the most useful way to begin building capabilities for small body exploration without needing to commit to specific mission architectures.
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Medical Data Architecture (MDA) Project Status
Krihak, M.; Middour, C.; Gurram, M.; Wolfe, S.; Marker, N.; Winther, S.; Ronzano, K.; Bolles, D.; Toscano, W.; Shaw, T.
2018-01-01
The Medical Data Architecture (MDA) project supports the Exploration Medical Capability (ExMC) risk to minimize or reduce the risk of adverse health outcomes and decrements in performance due to in-flight medical capabilities on human exploration missions. To mitigate this risk, the ExMC MDA project addresses the technical limitations identified in ExMC Gap Med 07: We do not have the capability to comprehensively process medically-relevant information to support medical operations during exploration missions. This gap identifies that the current in-flight medical data management includes a combination of data collection and distribution methods that are minimally integrated with on-board medical devices and systems. Furthermore, there are a variety of data sources and methods of data collection. For an exploration mission, the seamless management of such data will enable a more medically autonomous crew than the current paradigm. The medical system requirements are being developed in parallel with the exploration mission architecture and vehicle design. ExMC has recognized that in order to make informed decisions about a medical data architecture framework, current methods for medical data management must not only be understood, but an architecture must also be identified that provides the crew with actionable insight to medical conditions. This medical data architecture will provide the necessary functionality to address the challenges of executing a self-contained medical system that approaches crew health care delivery without assistance from ground support. Hence, the products supported by current prototype development will directly inform exploration medical system requirements.
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The human early-life exposome (HELIX): project rationale and design.
Vrijheid, Martine; Slama, Rémy; Robinson, Oliver; Chatzi, Leda; Coen, Muireann; van den Hazel, Peter; Thomsen, Cathrine; Wright, John; Athersuch, Toby J; Avellana, Narcis; Basagaña, Xavier; Brochot, Celine; Bucchini, Luca; Bustamante, Mariona; Carracedo, Angel; Casas, Maribel; Estivill, Xavier; Fairley, Lesley; van Gent, Diana; Gonzalez, Juan R; Granum, Berit; Gražulevičienė, Regina; Gutzkow, Kristine B; Julvez, Jordi; Keun, Hector C; Kogevinas, Manolis; McEachan, Rosemary R C; Meltzer, Helle Margrete; Sabidó, Eduard; Schwarze, Per E; Siroux, Valérie; Sunyer, Jordi; Want, Elizabeth J; Zeman, Florence; Nieuwenhuijsen, Mark J
2014-06-01
Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure-health effect relationships. The "exposome" concept encompasses the totality of exposures from conception onward, complementing the genome. The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the "early-life exposome." Here we describe the general design of the project. In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure models will be developed for the full cohorts totaling 32,000 mother-child pairs, and biomarkers will be measured in a subset of 1,200 mother-child pairs. Nested repeat-sampling panel studies (n = 150) will collect data on biomarker variability, use smartphones to assess mobility and physical activity, and perform personal exposure monitoring. Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple exposures will provide exposure-response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes. A health impact assessment exercise will evaluate risks and benefits of combined exposures. HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome.
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Directory of Open Access Journals (Sweden)
Beatriz Felipe Pérez
2016-06-01
Full Text Available Development banks are key actors in climate finance. During the last decades, they have increased the funding of climate change related projects, especially those under the Clean Development Mechanism (CDM. Defined in Article 12 of the Kyoto Protocol, the CDM aims at contributing to climate change mitigation while assisting in achieving sustainable development. However, many CDM projects have caused environmental damage and human rights abuses that especially affect the most vulnerable people. Located in Panama, the Barro Blanco hydro-power dam exemplifies the complex interrelationship of climate financing, development policies, the political and economic national context and human rights. Through the analysis of the role of development banks in climate finance, especially in the context of CDM projects, this paper aims (1 to clarify the role of development banks in climate finance, (2 to shed light on the vulnerable situation of the people affected by these projects, (3 to highlight the gaps in both the CDM rules and the development banks’ safeguard policies concerning the protection of human rights and the prevention of environmental abuses, and (4 to give a current example of this complex situation through the Barro Blanco case study. This paper argues that the manifold and often competing national and international legal and political layers of climate change mitigation projects repeatedly leave project affected people vulnerable to human rights violations without adequate safeguards and mechanisms to effectively articulate their interests, protect their rights and promote access to justice.
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Salah Alaloul, Wesam; Shahir Liew, Mohd; Zawawi, Noor Amila Wan
2017-12-01
The accomplishment of construction projects is extremely dependent on the integration of several stakeholders; therefore none of them has the control or the ability to accomplish the project alone. Each of them may influence and be influenced by the project management approach. There is no comprehensive theoretical platform for defining Communication, Coordination and Cooperation (3Cs) in the management of construction project. This paper deliberates the function of the 3Cs different theoretical perceptions. Through an analysis of selected articles from reputable academic journals in construction management, the business environment and human behaviour were identified as two main parts. A little has been done so far about the 3Cs, and how they are correlated with construction projects performance. Therefore, the objective of this paper is to explain the definitions and the association between the 3Cs. There is a significant link between communication and coordination. Coordination alternatively, is trust-based a logic of mutual and exchange. Consequently, cooperation is much more sophisticated, which needing more time and attempts.
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NASA Extreme Environment Mission Operations: Science Operations Development for Human Exploration
Bell, Mary S.
2014-01-01
The purpose of NASA Extreme Environment Mission Operations (NEEMO) mission 16 in 2012 was to evaluate and compare the performance of a defined series of representative near-Earth asteroid (NEA) extravehicular activity (EVA) tasks under different conditions and combinations of work systems, constraints, and assumptions considered for future human NEA exploration missions. NEEMO 16 followed NASA's 2011 Desert Research and Technology Studies (D-RATS), the primary focus of which was understanding the implications of communication latency, crew size, and work system combinations with respect to scientific data quality, data management, crew workload, and crew/mission control interactions. The 1-g environment precluded meaningful evaluation of NEA EVA translation, worksite stabilization, sampling, or instrument deployment techniques. Thus, NEEMO missions were designed to provide an opportunity to perform a preliminary evaluation of these important factors for each of the conditions being considered. NEEMO 15 also took place in 2011 and provided a first look at many of the factors, but the mission was cut short due to a hurricane threat before all objectives were completed. ARES Directorate (KX) personnel consulted with JSC engineers to ensure that high-fidelity planetary science protocols were incorporated into NEEMO mission architectures. ARES has been collaborating with NEEMO mission planners since NEEMO 9 in 2006, successively building upon previous developments to refine science operations concepts within engineering constraints; it is expected to continue the collaboration as NASA's human exploration mission plans evolve.
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National human genome projects: an update and an agenda.
An, Joon Yong
2017-01-01
Population genetic and human genetic studies are being accelerated with genome technology and data sharing. Accordingly, in the past 10 years, several countries have initiated genetic research using genome technology and identified the genetic architecture of the ethnic groups living in the corresponding country or suggested the genetic foundation of a social phenomenon. Genetic research has been conducted from epidemiological studies that previously described the health or disease conditions in defined population. This perspective summarizes national genome projects conducted in the past 10 years and introduces case studies to utilize genomic data in genetic research.
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Exploring linear algebra labs and projects with Mathematica
Arangala, Crista
2014-01-01
Matrix Operations Lab 0: An Introduction to Mathematica Lab 1: Matrix Basics and Operations Lab 2: A Matrix Representation of Linear Systems Lab 3: Powers, Inverses, and Special Matrices Lab 4: Graph Theory and Adjacency Matrices Lab 5: Permutations and Determinants Lab 6: 4 x 4 Determinants and Beyond Project Set 1 Invertibility Lab 7: Singular or Nonsingular? Why Singularity Matters Lab 8: Mod It Out, Matrices with Entries in ZpLab 9: It's a Complex World Lab 10: Declaring Independence: Is It Linear? Project Set 2 Vector Spaces Lab 11: Vector Spaces and SubspacesLab 12: Basing It All on Just a Few Vectors Lab 13: Linear Transformations Lab 14: Eigenvalues and Eigenspaces Lab 15: Markov Chains, An Application of Eigenvalues Project Set 3 Orthogonality Lab 16: Inner Product Spaces Lab 17: The Geometry of Vector and Inner Product SpacesLab 18: Orthogonal Matrices, QR Decomposition, and Least Squares Regression Lab 19: Symmetric Matrices and Quadratic Forms Project Set 4 Matrix Decomposition with Applications L...
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Financing uranium exploration and development projects in the 1990s
International Nuclear Information System (INIS)
Anon.
1990-01-01
The uranium production industry experienced momentous change during the decade of the 1980s. The Three Mile Island accident took place in the spring of 1979 and, while not necessarily creating the uranium open-quotes bustclose quotes of the ensuing decade, certainly set the tone for the entire nuclear power industry. Ever-increasing forecasts of installed commercial nuclear power coupled with a growing concern regarding the adequacy of uranium reserves and production capacity, ignited a wave of exploration and production capacity development in the mid-to-late 1970s which continued into the early 1980s. This momentum lead to over-production of uranium concentrates when compared to the eventual operation of commercial nuclear power plants. This material resulted in expanding inventories held by uranium producers and consumers alike. As these stockpiles inevitably found their way into the spot market, the price (as indicated by the NUEXCO Exchange Value) fell from a peak of $43.40 per pound U 3 O 8 in May 1978 to its current level of $8.80 per pound U 3 O 8 on April 30, 1990. As the nuclear power industry enters the 1990s, the debate regarding global warming and the subsequent role of nuclear power generation take on more importance. In any event, the nuclear power programs initiated principally in the 1970s are nearing completion. Even though new orders of power reactors have dropped precipitiously in the 1980s, the generation of electricity by nuclear fission accounts for almost twenty percent of WOCA (World Outside Centrally Planned Economies) electricity production. In order to place my main topic of financing future uranium exploration projects in perspective, I will review the conclusions of a uranium market study recently completed by NUEXCO Information Services, a group which closely monitors and evaluates the nuclear power industry and the nuclear fuel cycle
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NASA Intelligent Systems Project: Results, Accomplishments and Impact on Science Missions
Coughlan, Joseph C.
2005-01-01
The Intelligent Systems Project was responsible for much of NASA's programmatic investment in artificial intelligence and advanced information technologies. IS has completed three major project milestones which demonstrated increased capabilities in autonomy, human centered computing, and intelligent data understanding. Autonomy involves the ability of a robot to place an instrument on a remote surface with a single command cycle. Human centered computing supported a collaborative, mission centric data and planning system for the Mars Exploration Rovers and data understanding has produced key components of a terrestrial satellite observation system with automated modeling and data analysis capabilities. This paper summarizes the technology demonstrations and metrics which quantify and summarize these new technologies which are now available for future Nasa missions.
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Carrington, Connie; Howell, Joe
2001-01-01
The path to human presence beyond near-Earth will be paved by the development of infrastructure. A fundamental technology in this infrastructure is energy, which enables not only the basic function of providing shelter for man and machine, but also enables transportation, scientific endeavors, and exploration. This paper discusses the near-term needs in technology that develop the infrastructure for HEDS.
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From Mendel to the Human Genome Project: The Implications for Nurse Education.
Burton, Hilary; Stewart, Alison
2003-01-01
The Human Genome Project is brining new opportunities to predict and prevent diseases. Although pediatric nurses are the closest to these developments, most nurses will encounter genetic aspects of practice and must understand the basic science and its ethical, legal, and social dimensions. (Includes commentary by Peter Birchenall.) (SK)
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International Nuclear Information System (INIS)
2007-09-01
In 1999, the Project for Human Resources Development (HRD Project) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asia countries. In the Project there are two kinds of activity; In-workshop activity and Outside-workshop activity. The FNCA 2006 Workshop on HRD Project was held on July 31 - August 4, 2006, in Shenzhen, China. The Workshop was sponsored by the China Atomic Energy Authority (CAEA) and the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The China Atomic Energy Authority (CAEA) and the Japan Atomic Energy Agency (JAEA) acted as the hosts. Participating countries were China, Indonesia, Republic of Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. The activities of HRD Project was presented in the Eighth Coordinators Meeting of FNCA held on February 7th - 9th, 2007, in Tokyo, Japan. This report consists of presentation papers and materials at the FNCA 2006 Workshop, a review document of HRD Project for the Coordinators Meeting of FNCA as Outside-Workshop Activity. (author)
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International Nuclear Information System (INIS)
2006-10-01
In 1999, the Project for Human Resources Development (HRD Project) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project there are two kinds of activity; In-workshop activity and Outside-of-workshop activity. The FNCA 2005 Workshop on HRD Project was held on September 13-16, 2005, in Dalat, Viet Nam. The Workshop was sponsored by the Ministry of Science and Technology (MOST) of Viet Nam and the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The Vietnam Atomic Energy Commission (VAEC) and the Japan Atomic Energy Agency (JAEA) acted as the hosts. Participating countries were China, Indonesia, Republic of Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. The activities of HRD Project was presented in the Seventh Coordinators Meeting of FNCA was held on March 30 - April 1, 2006, in Tokyo, Japan. This report consists of presentation papers and materials at the FNCA 2005 Workshop, a review document of HRD Project for the Coordinators Meeting of FNCA as Outside-Workshop Activity. (author)
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Deep brain stimulation, brain maps and personalized medicine: lessons from the human genome project.
Fins, Joseph J; Shapiro, Zachary E
2014-01-01
Although the appellation of personalized medicine is generally attributed to advanced therapeutics in molecular medicine, deep brain stimulation (DBS) can also be so categorized. Like its medical counterpart, DBS is a highly personalized intervention that needs to be tailored to a patient's individual anatomy. And because of this, DBS like more conventional personalized medicine, can be highly specific where the object of care is an N = 1. But that is where the similarities end. Besides their differing medical and surgical provenances, these two varieties of personalized medicine have had strikingly different impacts. The molecular variant, though of a more recent vintage has thrived and is experiencing explosive growth, while DBS still struggles to find a sustainable therapeutic niche. Despite its promise, and success as a vetted treatment for drug resistant Parkinson's Disease, DBS has lagged in broadening its development, often encountering regulatory hurdles and financial barriers necessary to mount an adequate number of quality trials. In this paper we will consider why DBS-or better yet neuromodulation-has encountered these challenges and contrast this experience with the more successful advance of personalized medicine. We will suggest that personalized medicine and DBS's differential performance can be explained as a matter of timing and complexity. We believe that DBS has struggled because it has been a journey of scientific exploration conducted without a map. In contrast to molecular personalized medicine which followed the mapping of the human genome and the Human Genome Project, DBS preceded plans for the mapping of the human brain. We believe that this sequence has given personalized medicine a distinct advantage and that the fullest potential of DBS will be realized both as a cartographical or electrophysiological probe and as a modality of personalized medicine.
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The 2002 activities and the 4th workshop of the human resources development project in FNCA
International Nuclear Information System (INIS)
2003-07-01
In 1999, the Project for Human Resources Development (HRD Project) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project there are two kinds of activity; In-workshop activity and Outside-of-workshop activity. The 4th Workshop on HRD Project was held on october 8-10, 2002, in Batangas, the Philippines. The Workshop was sponsored by the Department of Science and Technology (DOST) of the Philippines and the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The Philippine Nuclear Research Institute (PNRI) and the Japan Atomic Energy Research Institute (JAERI) acted as the hosts. Participating countries were China, Indonesia, Republic of Korea, Japan, Malaysia, the Phillippines, Thailand, and Vietnam. This report consists of presentation papers and materials at the 4th workshop as In-Workshop Activity, a review document of HRD Project for the 5th Coordinators Meeting of FNCA at Tokyo on March, 2003, a letter of proposal from the Project Leader of Japan to the Project Leaders of the participating countries, and training materials of participating countries as Outside-Workshop Activity. (author)
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Human Outer Solar System Exploration via Q-Thruster Technology
Joosten, B. Kent; White, Harold G.
2014-01-01
Propulsion technology development efforts at the NASA Johnson Space Center continue to advance the understanding of the quantum vacuum plasma thruster (QThruster), a form of electric propulsion. Through the use of electric and magnetic fields, a Q-thruster pushes quantum particles (electrons/positrons) in one direction, while the Qthruster recoils to conserve momentum. This principle is similar to how a submarine uses its propeller to push water in one direction, while the submarine recoils to conserve momentum. Based on laboratory results, it appears that continuous specific thrust levels of 0.4 - 4.0 N/kWe are achievable with essentially no onboard propellant consumption. To evaluate the potential of this technology, a mission analysis tool was developed utilizing the Generalized Reduced Gradient non-linear parameter optimization engine contained in the Microsoft Excel® platform. This tool allowed very rapid assessments of "Q-Ship" minimum time transfers from earth to the outer planets and back utilizing parametric variations in thrust acceleration while enforcing constraints on planetary phase angles and minimum heliocentric distances. A conservative Q-Thruster specific thrust assumption (0.4 N/kWe) combined with "moderate" levels of space nuclear power (1 - 2 MWe) and vehicle specific mass (45 - 55 kg/kWe) results in continuous milli-g thrust acceleration, opening up realms of human spaceflight performance completely unattainable by any current systems or near-term proposed technologies. Minimum flight times to Mars are predicted to be as low as 75 days, but perhaps more importantly new "retro-phase" and "gravity-augmented" trajectory shaping techniques were revealed which overcome adverse planetary phasing and allow virtually unrestricted departure and return opportunities. Even more impressively, the Jovian and Saturnian systems would be opened up to human exploration with round-trip times of 21 and 32 months respectively including 6 to 12 months of
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Directory of Open Access Journals (Sweden)
Mohammed Sani
2018-03-01
Full Text Available Public Private Partnership (PPP Housing scheme in Nigeria is intended to complement government effort toward increasing housing stock and providing affordable housing in the country. However, Bauchi state government adopted the construction of 5,000 phases PPP Housing. But 6 years after the commencement of the scheme, only a few numbers of housing units were completed and commissioned. Therefore, it becomes imperative to carry out research on the impact level of those factors affecting the implementation of the scheme. The aim of the study is to investigate impact level of factors affecting the implementation of PPP housing projects in Bauchi state with a view to find out possible ways that will improve the implementation of the scheme. The descriptive and explorative research design was adopted for this study. 54 structured Questionnaires were administered to construction professional’s staff under private housing developers and relevant government agencies in Bauchi state. 42 valid Questionnaires were retrieved and analysed with SPSS software. The result of the quantitative data analysis shows that creation of favourable investment environment and government support have very high Impact on the implementation of Bauchi PPP housing projects. Therefore, this study recommends that government and other stakeholders should give more attention to the creation of favourable investment environment, support in policy formulation and managerial strategies in the future for improving the implementation of PPP housing projects.
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Next Generation Life Support Project Status
Barta, Daniel J.; Chullen, Cinda; Vega, Leticia; Cox, Marlon R.; Aitchison, Lindsay T.; Lange, Kevin E.; Pensinger, Stuart J.; Meyer, Caitlin E.; Flynn, Michael; Jackson, W. Andrew;
2014-01-01
Next Generation Life Support (NGLS) is one of over twenty technology development projects sponsored by NASA's Game Changing Development Program. The NGLS Project develops selected life support technologies needed for humans to live and work productively in space, with focus on technologies for future use in spacecraft cabin and space suit applications. Over the last three years, NGLS had five main project elements: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, High Performance (HP) Extravehicular Activity (EVA) Glove, Alternative Water Processor (AWP) and Series-Bosch Carbon Dioxide Reduction. The RCA swing bed, VOR and HP EVA Glove tasks are directed at key technology needs for the Portable Life Support System (PLSS) and pressure garment for an Advanced Extravehicular Mobility Unit (EMU). Focus is on prototyping and integrated testing in cooperation with the Advanced Exploration Systems (AES) Advanced EVA Project. The HP EVA Glove Element, new this fiscal year, includes the generation of requirements and standards to guide development and evaluation of new glove designs. The AWP and Bosch efforts focus on regenerative technologies to further close spacecraft cabin atmosphere revitalization and water recovery loops and to meet technology maturation milestones defined in NASA's Space Technology Roadmaps. These activities are aimed at increasing affordability, reliability, and vehicle self-sufficiency while decreasing mass and mission cost, supporting a capability-driven architecture for extending human presence beyond low-Earth orbit, along a human path toward Mars. This paper provides a status of current technology development activities with a brief overview of future plans.
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TA-55 facility control system upgrade project - human-system interface functional requirements
International Nuclear Information System (INIS)
Atkins, W.H.; Pope, N.G.; Turner, W.J.; Brown, R.E.
1995-11-01
The functional requirements for that part of the Technical Area (TA)-55 Operations Center Upgrade Project that involves the human-system interface (HSI) are described in this document. The upgrade project seeks to replace completely the center's existing computerized data acquisition and display system, which consists of the field multiplexer units, Data General computer systems, and associated peripherals and software. The upgrade project has two parts-the Facility Data Acquisition Interface System (FDAIS) and the HSI. The HSI comprises software and hardware to provide a high-level graphical operator interface to the data acquisition system, as well as data archiving, alarm annunciation, and logging. The new system will be built with modern, commercially available components; it will improve reliability and maintainability, and it can be expanded for future needs
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Schenkelberg, Theodore; Kieny, Marie-Paule; Bianco, A E; Koff, Wayne C
2015-05-01
The Human Vaccines Project is a bold new initiative, with the goal of solving the principal scientific problem impeding vaccine development for infectious diseases and cancers: the generation of specific, broad, potent and durable immune responses in humans. In the July 2014 workshop, 20 leaders from the public and private sectors came together to give input on strategic business issues for the creation of the Human Vaccines Project. Participants recommended the Project to be established as a nonprofit public-private partnership, structured as a global R&D consortium closely engaged with industrial partners, and located/affiliated with one or more major academic centers conducting vaccine R&D. If successful, participants concluded that the Project could greatly accelerate the development of new and improved vaccines, with the potential to transform disease prevention in the 21st century.
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Using Big Data to Understand the Human Condition: The Kavli HUMAN Project.
Azmak, Okan; Bayer, Hannah; Caplin, Andrew; Chun, Miyoung; Glimcher, Paul; Koonin, Steven; Patrinos, Aristides
2015-09-01
Until now, most large-scale studies of humans have either focused on very specific domains of inquiry or have relied on between-subjects approaches. While these previous studies have been invaluable for revealing important biological factors in cardiac health or social factors in retirement choices, no single repository contains anything like a complete record of the health, education, genetics, environmental, and lifestyle profiles of a large group of individuals at the within-subject level. This seems critical today because emerging evidence about the dynamic interplay between biology, behavior, and the environment point to a pressing need for just the kind of large-scale, long-term synoptic dataset that does not yet exist at the within-subject level. At the same time that the need for such a dataset is becoming clear, there is also growing evidence that just such a synoptic dataset may now be obtainable-at least at moderate scale-using contemporary big data approaches. To this end, we introduce the Kavli HUMAN Project (KHP), an effort to aggregate data from 2,500 New York City households in all five boroughs (roughly 10,000 individuals) whose biology and behavior will be measured using an unprecedented array of modalities over 20 years. It will also richly measure environmental conditions and events that KHP members experience using a geographic information system database of unparalleled scale, currently under construction in New York. In this manner, KHP will offer both synoptic and granular views of how human health and behavior coevolve over the life cycle and why they evolve differently for different people. In turn, we argue that this will allow for new discovery-based scientific approaches, rooted in big data analytics, to improving the health and quality of human life, particularly in urban contexts.
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Energy Technology Data Exchange (ETDEWEB)
NONE
2005-08-01
In 1999, the Project for Human Resources Development (HRD Project) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project there are two kinds of activity; in-workshop activity and Outside-of-workshop activity. The FNCA 2004 Workshop on HRD Project was held on October 4-7, 2004, in Kuala Lumpur, Malaysia. The Workshop was sponsored by the Ministry of Science and Technology Innovation (MOSTI) of Malaysia and the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The Malaysian Institute for Nuclear Technology Research (MINT) and the Japan Atomic Energy Research Institute (JAERI) acted as the hosts. Participating countries were China, Indonesia, Republic of Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. The activities of HRD Project was presented in the Sixth Coordinators Meeting of FNCA was held on March 30 - April 1, 2005, in Tokyo, Japan. This report consists of presentation papers and materials at the FNCA 2004 Workshop, a review document of HRD Project for the Coordinators Meeting of FNCA, a letter of request from the Project Leader of Japan to the Project Leaders of the participating countries and theme of the country report as Outside-Workshop Activity. (author)
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Responsible Mining: A Human Resources Strategy for Mine Development Project
Sampathkumar, Sriram (Ram)
2012-01-01
Mining is a global industry. Most mining companies operate internationally, often in remote, challenging environments and consequently frequently have respond to unusual and demanding Human Resource (HR) requirements. It is my opinion that the strategic imperative behind success in mining industry is responsible mining. The purpose of this paper is to examine how an effective HR strategy can be a competitive advantage that contributes to the success of a mining project in the global mining in...
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The Exploration of human experience in Jane Austen's Northanger Abbey
Mulas, Francesco Gesuino
2005-01-01
Jane Austen's purpose in Northanger Abbey, both in her aesthetic principles and moral intents, is to explore the human experience in its fullest sense. How do people perceive and understand themselves and each other? What are they like and how can they learn and grow? If moral problems are a question of thought rather than of action, as a consequence to ask what characters are like is also to ask what an author's conception of them should be.
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Baker, C.; Naikar, N.; Neerincx, M.
2008-01-01
The realisation of sustainable space exploration and utilisation requires not only the development of novel concepts and technologies, but also their successful integration. Hardware, software, and the human element must be integrated effectively to make the dream for which these technologies were
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Shaw, Jennifer
2016-02-01
The Human Genome Archive Project (HGAP) aimed to preserve the documentary heritage of the UK's contribution to the Human Genome Project (HGP) by using archival theory to develop a suitable methodology for capturing the results of modern, collaborative science. After assessing past projects and different archival theories, the HGAP used an approach based on the theory of documentation strategy to try to capture the records of a scientific project that had an influence beyond the purely scientific sphere. The HGAP was an archival survey that ran for two years. It led to ninety scientists being contacted and has, so far, led to six collections being deposited in the Wellcome Library, with additional collections being deposited in other UK repositories. In applying documentation strategy the HGAP was attempting to move away from traditional archival approaches to science, which have generally focused on retired Nobel Prize winners. It has been partially successful in this aim, having managed to secure collections from people who are not 'big names', but who made an important contribution to the HGP. However, the attempt to redress the gender imbalance in scientific collections and to improve record-keeping in scientific organisations has continued to be difficult to achieve. Copyright © 2015 The Author. Published by Elsevier Ltd.. All rights reserved.
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A Quest for Missing Proteins : update 2015 on Chromosome-Centric Human Proteome Project
Horvatovich, Péter; Lundberg, Emma K; Chen, Yu-Ju; Sung, Ting-Yi; He, Fuchu; Nice, Edouard C; Goode, Robert J A; Yu, Simon; Ranganathan, Shoba; Baker, Mark S; Domont, Gilberto B; Velasquez, Erika; Li, Dong; Liu, Siqi; Wang, Quanhui; He, Qing-Yu; Menon, Rajasree; Guan, Yuanfang; Corrales, Fernando Jose; Segura, Victor; Casal, José Ignacio; Pascual-Montano, Alberto; Albar, Juan Pablo; Fuentes, Manuel; Gonzalez-Gonzalez, Maria; Diez, Paula; Ibarrola, Nieves; Degano, Rosa M; Mohammed, Yassene; Borchers, Christoph H; Urbani, Andrea; Soggiu, Alessio; Yamamoto, Tadashi; Archakov, Alexander I; Ponomarenko, Elena; Lisitsa, Andrey V; Lichti, Cheryl F; Mostovenko, Ekaterina; Kroes, Roger A; Rezeli, Melinda; Vegvari, Akos; Fehniger, Thomas E; Bischoff, Rainer; Vizcaíno, Juan Antonio; Deutsch, Eric W; Lane, Lydie; Nilsson, Carol L; Marko-Varga, György; Omenn, Gilbert S; Jeong, Seul-Ki; Cho, Jin-Young; Paik, Young-Ki; Hancock, William S
2015-01-01
This paper summarizes the recent activities of the Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed "missing proteins") in biological samples that lack sufficient experimental evidence at the protein level
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The International Communication Project: Raising global awareness of communication as a human right.
Mulcair, Gail; Pietranton, Arlene A; Williams, Cori
2018-02-01
Communication as a human right is embedded within Article 19 of the Universal Declaration of Human Rights; however, there is a need to raise global awareness of the communication needs of those with communication disorders. In 2014, the six national speech-language and audiology professional bodies that comprise the Mutual Recognition Agreement (MRA) launched the International Communication Project (ICP) to help raise awareness of communication disorders around the world. Since its inception, the project has engaged close to 50 organisations from diverse regions, and has undertaken a number of initiatives, including development of the Universal Declaration of Communication Rights. A consultancy report was commissioned to inform ICP efforts to influence international policy bodies. As a result, the current focus of the ICP is to identify opportunities to influence the policies of organisations such as the World Health Organization, the United Nations and World Bank to more explicitly acknowledge and address communication as a human right. This commentary paper describes the work of the ICP to date, with an emphasis on the place of communication disorders in current international policy and potential pathways for advocacy.
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The pioneer projects: Economical exploration of the solar system
Spahr, J. R.; Hall, C. F.
1975-01-01
The interplanetary Pioneer missions are reviewed in terms of management implications and cost control. The responsibilities, organizational structure, and management practices of the Pioneer Projects are presented. The lines of authority and areas of responsibility of the principal organizational elements supporting the Pioneer missions are identified, and the methods employed for maintaining effective and timely interactions among these elements are indicated. The technical and administrative functions of the various organizational elements of the Pioneer Project Office at Ames Research Center are described in terms of their management responsibilities and interactions with other elements of the Project Office and with external organizations having Pioneer Project responsibilities. The management and control of activities prior to and during the hardware procurement phase are described to indicate the basis for obtaining visibility of the technical progress, utilization of resources, and cost performance of the contractors and other institutions supporting the Pioneer projects.
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AB052. The Human Variome Project (HVP) and the HVP ASEAN Node
Alwi, Zilfalil Bin
2015-01-01
The Human Variome Project (HVP) is an international NGO that is working to build capacity in responsible clinical genomics around the world. Founded in 2006, and lead in its early years by Professor Richard Cotton, the Project has grown to become a global movement with over 1,300 individual members from 81 countries and close to 200 data provider members. The project works to ensure that the lack of access to information on genetic variants and their effects on human health is not an impediment to diagnosis and treatment. Together with partner organisations including national and regional human genetics societies, national governments and intergovernmental organisations such as UNESCO—of which the HVP is an NGO official partner—the project establishes standards, guidelines and best practices for the responsible development and operation of genetic variation data sharing infrastructure, facilitates training and education of the public and the clinical genomics field and assists in embedding data sharing into routine clinical practice. The HVP believes that the free and open sharing of genetic variation is fundamental to providing quality clinical care. To ensure that this data can be collected, curated, interpreted and shared in a responsible manner that is respectful of the diverse ethical, legal and social differences of its member countries, the HVP works with local stakeholders in each country to establish HVP Country Nodes. An HVP Country Node is defined as having three components: (I) a repository, or linked network of databases, that collect and store information on variation in the human genome that has been generated within each country and that enables the sharing of that information both nationally and internationally; (II) a governance structure that ensures that the work of the Node is both sustainable in the long term and is consistent with all relevant national and international ethical, legal and social requirements; and (III) a set of policies
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Turner, R.; Huemann, M.; Keegan, A.
2008-01-01
As part of a wider study into human resource management (HRM) practices in project-oriented organizations, we investigated the issue of employee well-being. Project-oriented organizations adopt temporary work processes to deliver products and services to clients. This creates a dynamic work environment, where additional pressures can be imposed on the employee from fluctuating work-loads, uncertain requirements, and multiple role demands. These pressures can create issues for employee well-be...
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Something of value Governance of Projects in the Project-Based Organisation
DEFF Research Database (Denmark)
Riis, Eva
2013-01-01
The paper presents a conceptual framework for studying Governance of Projects and issues of value in the project-based organisation. Attempts at exploring and conceptualising the issues in the current literature are reviewed. Issues pertinent to gaining value by Governance of Projects have mainly...... for a better understanding of Governance of Projects and value contribution. The findings presented here form the conceptual foundation for subsequent empirical studies of value by Governance of Projects....... been explored from the perspective of economic theory. Models found in the literature are not typically concerned with value for the implementing organisation as a whole; their scope is limited to the time just after project completion. No valid, empirically-based models of value creation by Governance...
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Models of the Human in Tantric Hinduism
DEFF Research Database (Denmark)
Olesen, Bjarne Wernicke; Flood, Gavin
2019-01-01
This research project explores the origins, developments and transformations of yogic models of the human (e.g. kuṇḍalinī yoga, the cakra system and ritual sex) in the tantric goddess traditions or what might be called Śāktism of medieval India. These Śākta models of esoteric anatomy originating...
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The Human Variome Project (HVP) 2009 Forum "Towards Establishing Standards".
Howard, Heather J; Horaitis, Ourania; Cotton, Richard G H; Vihinen, Mauno; Dalgleish, Raymond; Robinson, Peter; Brookes, Anthony J; Axton, Myles; Hoffmann, Robert; Tuffery-Giraud, Sylvie
2010-03-01
The May 2009 Human Variome Project (HVP) Forum "Towards Establishing Standards" was a round table discussion attended by delegates from groups representing international efforts aimed at standardizing several aspects of the HVP: mutation nomenclature, description and annotation, clinical ontology, means to better characterize unclassified variants (UVs), and methods to capture mutations from diagnostic laboratories for broader distribution to the medical genetics research community. Methods for researchers to receive credit for their effort at mutation detection were also discussed. (c) 2010 Wiley-Liss, Inc.
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Hematopoietic Stem Cell Therapy as a Counter-Measure for Human Exploration of Deep Space
Ohi, S.; Roach, A.-N.; Ramsahai, S.; Kim, B. C.; Fitzgerald, W.; Riley, D. A.; Gonda, S. R.
2004-01-01
Human exploration of deep space depends, in part, on our ability to counter severe/invasive disorders that astronauts experience in space environments. The known symptoms include hematological/cardiac abnormalities,bone and muscle losses, immunodeficiency, neurological disorders, and cancer. Exploiting the extraordinary plasticity of hematopoietic stem cells (HSCs), which differentiate not only to all types of blood cells, but also to various tissues, we have advanced a hypothesis that ome of the space-caused disorders maybe amenable to hematopoietis stem cell therapy(HSCT) so as to maintain promote human exploration of deep space. Using mouse models of human anemia beta-thaiassemia) as well as spaceflight (hindlimb unloading system), we have obtained feasibility results of HSCT for space anemia, muscle loss, and immunodeficiency. For example, in the case of HSCT for muscle loss, the beta-galactosidese marked HSCs were detected in the hindlimbs of unloaded mouse following transplantation by -X-gal wholemaunt staining procedure. Histochemicaland physical analyses indicated structural contribution of HSCs to the muscle. HSCT for immunodeficiency was investigated ising beta-galactosidese gene-tagged Escherichia coli as the infectious agent. Results of the X-gal staining procedure indicated the rapeutic role of the HSCT. To facilitate the HSCT in space, growth of HSCs were optimized in the NASA Rotating Wall Vessel (RWV) culture systems, including Hydrodynamic Focusing Bioreactor (HFB).
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Building and Leading the Next Generation of Exploration Launch Vehicles
Cook, Stephen A.; Vanhooser, Teresa
2010-01-01
NASA s Constellation Program is depending on the Ares Projects to deliver the crew and cargo launch capabilities needed to send human explorers to the Moon and beyond. Ares I and V will provide the core space launch capabilities needed to continue providing crew and cargo access to the International Space Station (ISS), and to build upon the U.S. history of human spaceflight to the Moon and beyond. Since 2005, Ares has made substantial progress on designing, developing, and testing the Ares I crew launch vehicle and has continued its in-depth studies of the Ares V cargo launch vehicle. In 2009, the Ares Projects plan to: conduct the first flight test of Ares I, test-fire the Ares I first stage solid rocket motor; build the first integrated Ares I upper stage; continue testing hardware for the J-2X upper stage engine, and continue refining the design of the Ares V cargo launch vehicle. These efforts come with serious challenges for the project leadership team as it continues to foster a culture of ownership and accountability, operate with limited funding, and works to maintain effective internal and external communications under intense external scrutiny.
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JAXA's Space Exploration Scenario
Sato, N. S.
2018-04-01
Japan Aerospace Exploration Agency (JAXA) has been studying space exploration scenario, including human exploration for Japan since 2015, which encompasses goals, knowledge gap assessment, and architecture. assessment, and technology roadmap.
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Managing the Right Projects: Best Practices to Align Project and Corporate Strategies
Watkins, Bobby
2012-01-01
If there's a human endeavor that exemplifies teamwork, it is space exploration. And that teamwork absolutely cannot happen effectively if the boots on the ground the people doing the work - don't understand how their work aligns with the larger goal. This presentation will discuss some best management practices from NASA's Marshall Space Flight Center that have succeeded in helping employees become informed, engaged and committed to the space agency's important missions. Specific topics include: Alignment Criteria: Linking Projects To Corporate Strategy. Resource Management: Best Practices For Resource Management. Strategic Analysis: Supporting Decision Making In A Changing Environment. Communication Strategies: Best Practices To Communicate Change. Benefits Achieved And Lessons Learned.
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Understanding the Human Genome Project — A Fact Sheet | NIH MedlinePlus the Magazine
... The Human Genome Project spurred a revolution in biotechnology innovation around the world and played a key ... the U.S. the global leader in the new biotechnology sector. In April 2003, researchers successfully completed the ...
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Cradle-to-Grave Logistic Technologies for Exploration Missions
Broyan, James L.; Ewert, Michael K.; Shull, Sarah
2013-01-01
Human exploration missions under study are very limited by the launch mass capacity of exiting and planned vehicles. The logistical mass of crew items is typically considered separate from the vehicle structure, habitat outfitting, and life support systems. Consequently, crew item logistical mass is typically competing with vehicle systems for mass allocation. NASA is Advanced Exploration Systems (AES) Logistics Reduction and Repurposing (LRR) Project is developing four logistics technologies guided by a systems engineering cradle-to-grave approach to enable used crew items to augment vehicle systems. Specifically, AES LRR is investigating the direct reduction of clothing mass, the repurposing of logistical packaging, the processing of spent crew items to benefit radiation shielding and water recovery, and the conversion of trash to propulsion supply gases. The systematic implementation of these types of technologies will increase launch mass efficiency by enabling items to be used for secondary purposes and improve the habitability of the vehicle as the mission duration increases. This paper provides a description, benefits, and challenges of the four technologies under development and a status of progress at the mid ]point of the three year AES project.
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SLS-Derived Lab: Precursor to Deep Space Human Exploration
Griffin, Brand; Lewis, Ruthan; Eppler, Dean; Smitherman, David
2014-01-01
Plans to send humans to Mars are in work and the launch system is being built. Are we ready? Robotic missions have successfully demonstrated transportation, entry, landing and surface operations but for human missions there are significant, potentially show-stopping issues. These issues, called Strategic Knowledge Gaps (SKGs) are the unanswered questions concerning long-duration exploration beyond low-earth-orbit. The gaps represent a risk of loss of life or mission and because they require extended exposure to the weightless environment outside earth's protective geo-magnetic field they cannot be resolved on the earth or on the International Space Station (ISS). Placing a laboratory at the relatively close and stable lunar Distant Retrograde Orbit (DRO) provides an accessible location with the requisite environmental conditions for conducting SKG research and testing mitigation solutions. Configurations comprised of multiple 3 meter and 4.3 meter diameter modules have been studied but the most attractive solution uses elements of the human Mars launch vehicle or Space Launch System (SLS) for a Mars proving ground laboratory. A shortened version of an SLS hydrogen propellant tank creates a Skylab-like pressure vessel that flies fully outfitted on a single launch. This not only offers significant savings by incorporating SLS pressure vessel development costs but avoids the expensive ISS approach using many launches with substantial on-orbit assembly before becoming operational. One of the most challenging SKGs is crew radiation protection; this is why SKG laboratory research is combined with Mars transit Habitat systems development. Fundamentally, the two cannot be divorced because using the habitat systems for protection requires actual hardware geometry and material properties intended to contribute to shielding effectiveness. The SKGs are difficult problems, solutions are not obvious, and require integrated, iterative, and multi-disciplinary development. A lunar
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SLS-Derived Lab- Precursor to Deep Space Human Exploration
Griffin, Brand M.; Lewis, Ruthan; Eppler, Dean; Smitherman, David
2015-01-01
Plans to send humans to Mars are in the works and the launch system is being built. Are we ready? Transportation, entry, landing, and surface operations have been successfully demonstrated for robotic missions. However, for human missions, there are significant, potentially show-stopping issues. These issues, called Strategic Knowledge Gaps (SKGs), are the unanswered questions concerning long duration exploration Beyond low Earth Orbit (BEO). The gaps represent a risk of loss of life or mission and because they require extended exposure to the weightless environment outside of earth's protective geo-magnetic field, they cannot be resolved on Earth or on the International Space Station (ISS). Placing a laboratory at a relatively close and stable lunar Distant Retrograde Orbit (DRO) provides an accessible location with the requisite environmental conditions for conducting SKG research and testing mitigation solutions. Configurations comprised of multiple 3 m and 4.3 m diameter modules have been studied but the most attractive solution uses elements of the human Mars launch vehicle or Space Launch System (SLS) for a Mars proving ground laboratory. A shortened version of an SLS hydrogen propellant tank creates a Skylab-like pressure vessel that flies fully outfitted on a single launch. This not only offers significant savings by incorporating SLS pressure vessel development costs but avoids the expensive ISS approach using many launches with substantial on-orbit assembly before becoming operational. One of the most challenging SKGs is crew radiation protection; this is why SKG laboratory research is combined with Mars transit habitat systems development. Fundamentally, the two cannot be divorced because using the habitat systems for protection requires actual hardware geometry and material properties intended to contribute to shielding effectiveness. The SKGs are difficult problems. The solutions to these problems are not obvious; they require integrated, iterative
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Planning a change project in mental health nursing.
Thorpe, Rebecca
2015-09-02
This article outlines a plan for a change project to improve the quality of physical health care on mental health wards. The plan was designed to improve the monitoring and recording of respiratory rates on mental health wards, through the implementation of a training programme for staff. A root cause analysis was used to explore the reasons for the low incidence of respiratory rate measurement on mental health wards, and the results of this establish the basis of the proposed change project and its aims and objectives. The article describes how the project could be implemented using a change management model, as well as how its effects could be measured and evaluated. Potential barriers to the planned change project are discussed, including the human dimensions of change. The article suggests methods to overcome such barriers, discusses the value of leadership as an important factor, and examines the principles of clinical governance in the context of the planned change project.
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Enzymatic production of human milk oligosaccharides
DEFF Research Database (Denmark)
Holck, Jesper; Jers, Carsten; Michalak, Malwina
2014-01-01
Human milk oligosaccharides (HMOs) are a group of complex glycans that are abundant in human breastmilk. Breastfeeding infants is linked to several beneficial effects like promotion of bifidogenic growth,anti‐adhesive effects by blocking pathogens, and sialylated HMOs are moreover involved...... in infant brain development. Only trace amounts of these oligosaccharides are present in bovine milk‐based infantformula. In order to produce genuine HMOs, this project explores a sustainable way to develop anenzymatic process capable of converting certain kinds of food materials into the desired products....
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Audio-Tutorial Project: An Audio-Tutorial Approach to Human Anatomy and Physiology.
Muzio, Joseph N.; And Others
A two course sequence on human anatomy and physiology using the audiotutorial method of instruction was developed for use by nursing students and other students in the health or medical fields at the Kingsborough Community College in New York. The project was motivated by the problems of often underprepared students coming to learn a new field and…
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Davis, Jeffrey R.
2012-01-01
In May of 2007, The Space Life Sciences Strategy was published, launching a series of efforts aimed at driving human health and performance innovations that both meet space flight needs and benefit life on Earth. These efforts, led by the Space Life Science Directorate (SLSD) at the NASA Johnson Space Center, led to the development and implementation of the NASA Human Health and Performance Center (NHHPC) in October 2010. The NHHPC now has over 100 members including seven NASA centers; other federal agencies; some of the International Space Station partners; industry; academia and non-profits. The NHHPC seeks to share best practices, develop collaborative projects and experiment with open collaboration techniques such as crowdsourcing. Using this approach, the NHHPC collaborative projects are anticipated to be at the earliest possible stage of development utilizing the many possible public-private partnerships in this center. Two workshops have been successfully conducted in 2011 (January and October) with a third workshop planned for the spring of 2012. The challenges of space flight are similar in many respects to providing health care and environmental monitoring in challenging settings on the earth. These challenges to technology development include the need for low power consumption, low weight, in-situ analysis, operator independence (i.e., minimal training), robustness, and limited resupply or maintenance. When similar technology challenges are identified (such as the need to provide and monitor a safe water supply or develop a portable medical diagnostic device for remote use), opportunities arise for public-private partnerships to engage in co-creation of novel approaches for space exploration and health and environmental applications on earth. This approach can enable the use of shared resources to reduce costs, engage other organizations and the public in participatory exploration (solving real-world problems), and provide technologies with multiple uses
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Byrne, Vicky; Orndoff, Evelyne; Poritz, Darwin; Schlesinger, Thilini
2013-01-01
All human space missions require significant logistical mass and volume that will become an excessive burden for long duration missions beyond low Earth orbit. The goal of the Advanced Exploration Systems (AES) Logistics Reduction & Repurposing (LRR) project is to bring new ideas and technologies that will enable human presence in farther regions of space. The LRR project has five tasks: 1) Advanced Clothing System (ACS) to reduce clothing mass and volume, 2) Logistics to Living (L2L) to repurpose existing cargo, 3) Heat Melt Compactor (HMC) to reprocess materials in space, 4) Trash to Gas (TTG) to extract useful gases from trash, and 5) Systems Engineering and Integration (SE&I) to integrate these logistical components. The current International Space Station (ISS) crew wardrobe has already evolved not only to reduce some of the logistical burden but also to address crew preference. The ACS task is to find ways to further reduce this logistical burden while examining human response to different types of clothes. The ACS task has been broken into a series of studies on length of wear of various garments: 1) three small studies conducted through other NASA projects (MMSEV, DSH, HI-SEAS) focusing on length of wear of garments treated with an antimicrobial finish; 2) a ground study, which is the subject of this report, addressing both length of wear and subject perception of various types of garments worn during aerobic exercise; and 3) an ISS study replicating the ground study, and including every day clothing to collect information on perception in reduced gravity in which humans experience physiological changes. The goal of the ground study is first to measure how long people can wear the same exercise garment, depending on the type of fabric and the presence of antimicrobial treatment, and second to learn why. Human factors considerations included in the study consist of the Institutional Review Board approval, test protocol and participants' training, and a web
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Warmflash, David; Larios-Sanz, Maia; Jones, Jeffrey; Fox, George E.; McKay, David S.
2007-01-01
Exploration Class missions to Mars will require precautions against potential contamination by any native microorganisms that may be incidentally pathogenic to humans. While the results of NASA's Viking biology experiments of 1976 have been generally interpreted as inconclusive for surface organisms, the possibility of native surface life has never been ruled out and more recent studies suggest that the case for biological interpretation of the Viking Labeled Release data may now be stronger than it was when the experiments were originally conducted. It is possible that, prior to the first human landing on Mars, robotic craft and sample return missions will provide enough data to know with certainty whether or not future human landing sites harbor extant life forms. However, if native life is confirmed, it will be problematic to determine whether any of its species may present a medical risk to astronauts. Therefore, it will become necessary to assess empirically the risk that the planet contains pathogens based on terrestrial examples of pathogenicity and to take a reasonably cautious approach to bio-hazard protection. A survey of terrestrial pathogens was conducted with special emphasis on those pathogens whose evolution has not depended on the presence of animal hosts. The history of the development and implementation of Apollo anticontamination protocol and recent recommendations of the NRC Space Studies Board regarding Mars were reviewed. Organisms can emerge in nature in the absence of indigenous animal hosts and both infectious and non-infectious human pathogens are theoretically possible on Mars. The prospect of Martian surface life, together with the existence of a diversity of routes by which pathogenicity has emerged on Earth, suggests that the possibility of human pathogens on Mars, while low, is not zero. Since the discovery and study of Martian life can have long-term benefits for humanity, the risk that Martian life might include pathogens should not
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Virtual reality haptic human dissection.
Needham, Caroline; Wilkinson, Caroline; Soames, Roger
2011-01-01
This project aims to create a three-dimensional digital model of the human hand and wrist which can be virtually 'dissected' through a haptic interface. Tissue properties will be added to the various anatomical structures to replicate a realistic look and feel. The project will explore the role of the medical artist and investigate the cross-discipline collaborations required in the field of virtual anatomy. The software will be used to train anatomy students in dissection skills before experience on a real cadaver. The effectiveness of the software will be evaluated and assessed both quantitatively as well as qualitatively.
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International Nuclear Information System (INIS)
Yao Zhenkai
2012-01-01
A composite evaluation model of commercial geological exploration and mining development project was discussed, this new model consists of polity-economy-technique (PET) synthetic evaluation sub-model and geology-mining-metallurgy (GMM) technique evaluation sub-model. Besides, some key technical problems in commercial negotiation, such as information screening, quoted price and analysis of deadline, were briefly analyzed. (author)
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Directory of Open Access Journals (Sweden)
Allison L Mayberry
2017-01-01
Full Text Available High densities of wild African savannah elephants (Loxodonta africana combined with widespread human land-use have increased human-elephant conflict in northern Botswana. Visible impacts (e.g. crop/property damage, injury/fatality of elephants on human well-being are well documented in scholarly literature while hidden impacts (e.g. emotional stress, restricted mobility are less so. This research uses qualitative methods to explore human experiences with elephants and perceived impacts of elephants on human well-being. Findings reveal participants are concerned about food insecurity and associated visible impacts of elephant crop raids. Findings also reveal participants are concerned about reduced safety and restricted mobility as hidden impacts threatening livelihoods and everyday life. Both visible and hidden impacts of elephants contribute to people's negative feelings towards elephants, as does the broader political context. This research emphasises the importance of investigating both visible and hidden impacts of elephants on human well-being to foster holistic understanding of human-elephant conflict scenarios and to inform future mitigation strategies.
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2013-02-05
... NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request; Education and Human Resources Project Monitoring Clearance AGENCY: National Science Foundation. ACTION: Notice... study will assess the implementation of resources, models, and technologies to determine how and why...
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Crew Exploration Vehicle (CEV) (Orion) Occupant Protection
Currie-Gregg, Nancy J.; Gernhardt, Michael L.; Lawrence, Charles; Somers, Jeffrey T.
2016-01-01
Dr. Nancy J. Currie, of the NASA Engineering and Safety Center (NESC), Chief Engineer at Johnson Space Center (JSC), requested an assessment of the Crew Exploration Vehicle (CEV) occupant protection as a result of issues identified by the Constellation Program and Orion Project. The NESC, in collaboration with the Human Research Program (HRP), investigated new methods associated with occupant protection for the Crew Exploration Vehicle (CEV), known as Orion. The primary objective of this assessment was to investigate new methods associated with occupant protection for the CEV, known as Orion, that would ensure the design provided minimal risk to the crew during nominal and contingency landings in an acceptable set of environmental and spacecraft failure conditions. This documents contains the outcome of the NESC assessment. NASA/TM-2013-217380, "Application of the Brinkley Dynamic Response Criterion to Spacecraft Transient Dynamic Events." supercedes this document.
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Exploration Medical Capability (ExMC) Projects
Wu, Jimmy; Watkins, Sharmila; Baumann, David
2010-01-01
During missions to the Moon or Mars, the crew will need medical capabilities to diagnose and treat disease as well as for maintaining their health. The Exploration Medical Capability Element develops medical technologies, medical informatics, and clinical capabilities for different levels of care during space missions. The work done by team members in this Element is leading edge technology, procedure, and pharmacological development. They develop data systems that protect patient's private medical information, aid in the diagnosis of medical conditions, and act as a repository of relevant NASA life sciences experimental studies. To minimize the medical risks to crew health the physicians and scientists in this Element develop models to quantify the probability of medical events occurring during a mission. They define procedures to treat an ill or injured crew member who does not have access to an emergency room and who must be cared for in a microgravity environment where both liquids and solids behave differently than on Earth. To support the development of these medical capabilities, the Element manages the development of medical technologies that prevent, monitor, diagnose, and treat an ill or injured crewmember. The Exploration Medical Capability Element collaborates with the National Space Biomedical Research Institute (NSBRI), the Department of Defense, other Government-funded agencies, academic institutions, and industry.
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Exploring project selection behavior of academic scientists in India
Anju Chawla
2007-01-01
This study is based on retrospective accounts of a stratified sample of about 1,100 academic scien-tists in India on the criteria actually used by them in the choice of research projects. A basic objective is to examine the effects of contextual factors such as academic rank, institutional and disciplinary setting, and sources of research funds on the choice of research projects. A struc-tured questionnaire was used to tap the criteria for project selection. The items were factor-analyzed and...
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Warwick, C.; Terras, M.; Huntington, P.; Pappa, N.; Galina, I.
2007-01-01
This paper describes the results of research carried out during the LAIRAH (Log analysis of Internet Resources in the Arts and Humanities) project (http://www.ucl.ac.uk/slais/circah/lairah/) which is based at UCL’s School of Library Archive and Information Studies. It was a fifteen month study (reporting in October 2006) to discover what influences the long-term sustainability and use of digital resources in the humanities through the analysis and evaluation of real-time use. At Digital Human...
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Smith, Heather; Duncan, Andrew
2016-07-01
The University Rover Challenge began in 2006 with 4 American college teams competing, now in it's 10th year there are 63 teams from 12 countries registered to compete for the top rover designed to assist humans in the exploration of Mars. The Rovers compete aided by the University teams in four tasks (3 engineering and 1 science) in the Mars analog environment of the Utah Southern Desert in the United States. In this presentation we show amazing rover designs with videos demonstrating the incredible ingenuity, skill and determination of the world's most talented college students. We describe the purpose and results of each of the tasks: Astronaut Assistant, Rover Dexterity, Terrain maneuvering, and Science. We explain the evolution of the competition and common challenges faced by the robotic explorers
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Taylor, G. J.; Martel, L. M. V.
2018-04-01
Lunar-focused research and plans to return to the lunar surface for science and exploration have reemerged since the Space Policy Directive-1 of December 11, 2017 amended the National Space Policy to include the following, "Lead an innovative and sustainable program of exploration with commercial and international partners to enable human expansion across the solar system and to bring back to Earth new knowledge and opportunities. Beginning with missions beyond low-Earth orbit, the United States will lead the return of humans to the Moon for long-term exploration and utilization, followed by human missions to Mars and other destinations." In response to this revision, NASA proposes a Lunar Exploration and Discovery Program in the U.S. fiscal year 2019 Budget Request. It supports NASA's interests in commercial and international partnerships in Low-Earth Orbit (LEO), long-term exploration in Cislunar space beyond LEO, and research and exploration conducted on the Moon to inform future crewed missions, even to destinations beyond the Moon. (Cislunar refers to the volume of space between LEO and the Moon's orbital distance.) The lunar campaign strengthens the integration of human and robotic activities on the lunar surface with NASA's science, technology, and exploration goals.
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An exploration in the will psychology of Otto Rank: human intentionality and individuality.
Isono, Masayo
2012-12-01
The author explores the meaning and the importance of the will in Rank's relation-based self-creative, self-constructive psychology and argues for the consideration of the concept of the will in psychoanalysis. The paper shows that Rank's concept of the will explains what gives a human being the impetus to choose an action, positive or negative. When validated by the other, this will, the power of intention, enables a person to create his/her unique individuality. The paper reviews Rank's definition of will and traces the evolution of his ideas of intentionality in his writings. Further, the author discusses how Rank attempts to capture the subtle movements of the human mind as suffused with struggles and dynamic interplay between external and internal forces.
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Historic Cosmology Identity and Exploration
Nebergall, K.
The role of the soul and spirit in the composition of human endeavour generally takes the form of motivational poster catch phrases or third-hand quotes. If the spirit equals the life of a creature, and one of the signs of life is locomotion, are humans not obliged by something even deeper than our humanity to explore the universe? This paper examines the roots and perspectives of our worldviews on identity, exploration, and the limitations and capacities of humanity. It will equip the reader to discuss the nature of exploration with audiences across a wide range of worldviews. Current cultures, regardless of religion or politics, are looped into a series of nihilistic patterns that must be broken by rediscovering our nature as living beings, and our obligations as human beings.
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The Human Genome Project and Mental Retardation: An Educational Program. Final Progress Report
Energy Technology Data Exchange (ETDEWEB)
Davis, Sharon
1999-05-03
The Arc, a national organization on mental retardation, conducted an educational program for members, many of whom have a family member with a genetic condition causing mental retardation. The project informed members about the Human Genome scientific efforts, conducted training regarding ethical, legal and social implications and involved members in issue discussions. Short reports and fact sheets on genetic and ELSI topics were disseminated to 2,200 of the Arc's leaders across the country and to other interested individuals. Materials produced by the project can e found on the Arc's web site, TheArc.org.
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Exploring the capital markets and securitisation for renewable energy projects
Energy Technology Data Exchange (ETDEWEB)
Haggard, M.E.; Thompson, M.A.; Colonna, S.
2000-07-01
This study looks at the opportunities for renewable energy projects to access the bond market to finance projects or refinance existing projects, and what, if anything, is required to facilitate this. In addition, the study looks at the possible use of securitisation to group projects together as a means of dealing with some of the challenges faced by renewables, such as small size relative to most bond issues and the transaction costs. (author)
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Exploring the capital markets and securitisation for renewable energy projects
International Nuclear Information System (INIS)
Haggard, M.E.; Thompson, M.A.; Colonna, S.
2000-01-01
This study looks at the opportunities for renewable energy projects to access the bond market to finance projects or refinance existing projects, and what, if anything, is required to facilitate this. In addition, the study looks at the possible use of securitisation to group projects together as a means of dealing with some of the challenges faced by renewables, such as small size relative to most bond issues and the transaction costs. (author)
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Directory of Open Access Journals (Sweden)
David Abram
2013-12-01
Full Text Available From an initial project to investigate the relationship between magic and traditional medicine as practiced by shamans in Southern rural Asia, the focus of attention gradually shifted to an awareness of the negotiation traditional medicine people or shamans exert between the human community and the larger community of beings. This attentiveness to a more-than-human world does not occur at a supernatural domain above nature or inside her personal self but is the result of the shaman’s special ability to project her consciousness horizontally to other forms of sensibility with which human existence is interwoven. The ecological function of the shaman is to maintain a constant balance between what is taken and what is given from the human community to the larger community. The spirits of indigenous cultures are not defined in opposition to materiality but are essentially those modes of intelligence or awareness that do not possess a human form. By exploring different landscapes, and the sensibility living in them, a new sensitivity is awoken that allows for communication with those intelligences. However, the drowning of these other voices in Western culture, which reduces otherness to an object, creates an uneasiness that is hardly perceived except as an inability to interact with anything more-than-human and its dire consequences in the form of “civilization’s” destructive behavior.
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Cole, Ann F.; McArdle, Geri; Clements, Kimberly D.
2005-01-01
Human resource development professionals are in a unique position to help organizations achieve maximum positive impact and avoid legal difficulties when implementing mentoring programs. This case study explored a formal mentoring program that was data-based and linked to HRD in order to advance the mentoring process as an effective individual and…
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Diller, Kyle I; Bayden, Alexander S; Audie, Joseph; Diller, David J
2018-01-01
There is growing interest in peptide-based drug design and discovery. Due to their relatively large size, polymeric nature, and chemical complexity, the design of peptide-based drugs presents an interesting "big data" challenge. Here, we describe an interactive computational environment, PeptideNavigator, for naturally exploring the tremendous amount of information generated during a peptide drug design project. The purpose of PeptideNavigator is the presentation of large and complex experimental and computational data sets, particularly 3D data, so as to enable multidisciplinary scientists to make optimal decisions during a peptide drug discovery project. PeptideNavigator provides users with numerous viewing options, such as scatter plots, sequence views, and sequence frequency diagrams. These views allow for the collective visualization and exploration of many peptides and their properties, ultimately enabling the user to focus on a small number of peptides of interest. To drill down into the details of individual peptides, PeptideNavigator provides users with a Ramachandran plot viewer and a fully featured 3D visualization tool. Each view is linked, allowing the user to seamlessly navigate from collective views of large peptide data sets to the details of individual peptides with promising property profiles. Two case studies, based on MHC-1A activating peptides and MDM2 scaffold design, are presented to demonstrate the utility of PeptideNavigator in the context of disparate peptide-design projects. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Benefits of Microalgae for Human Space Exploration
Verrecchia, Angelique; Bebout, Brad M.; Murphy, Thomas
2015-01-01
Algae have long been known to offer a number of benefits to support long duration human space exploration. Algae contain proteins, essential amino acids, vitamins, and lipids needed for human consumption, and can be produced using waste streams, while consuming carbon dioxide, and producing oxygen. In comparison with higher plants, algae have higher growth rates, fewer environmental requirements, produce far less "waste" tissue, and are resistant to digestion and/or biodegradation. As an additional benefit, algae produce many components (fatty acids, H2, etc.) which are useful as biofuels. On Earth, micro-algae survive in many harsh environments including low humidity, extremes in temperature, pH, and as well as high salinity and solar radiation. Algae have been shown to survive inmicro-gravity, and can adapt to high and low light intensity while retaining their ability to perform nitrogen fixation and photosynthesis. Studies have demonstrated that some algae are resistant to the space radiation environment, including solar ultraviolet radiation. It remains to be experimentally demonstrated, however, that an algal-based system could fulfil the requirements for a space-based Bioregenerative Life Support System (BLSS) under comparable spaceflight power, mass, and environmental constraints. Two specific challenges facing algae cultivation in space are that (i) conventional growth platforms require large masses of water, which in turn require a large amount of propulsion fuel, and (ii) most nutrient delivery mechanisms (predominantly bubbling) are dependent on gravity. To address these challenges, we have constructed a low water biofilm based bioreactor whose operation is enabled by capillary forces. Preliminary characterization of this Surface Adhering BioReactor (SABR) suggests that it can serve as a platform for cultivating algae in space which requires about 10 times less mass than conventional reactors without sacrificing growth rate. Further work is necessary to
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Simulation Based Acquisition for NASA's Office of Exploration Systems
Hale, Joe
2004-01-01
In January 2004, President George W. Bush unveiled his vision for NASA to advance U.S. scientific, security, and economic interests through a robust space exploration program. This vision includes the goal to extend human presence across the solar system, starting with a human return to the Moon no later than 2020, in preparation for human exploration of Mars and other destinations. In response to this vision, NASA has created the Office of Exploration Systems (OExS) to develop the innovative technologies, knowledge, and infrastructures to explore and support decisions about human exploration destinations, including the development of a new Crew Exploration Vehicle (CEV). Within the OExS organization, NASA is implementing Simulation Based Acquisition (SBA), a robust Modeling & Simulation (M&S) environment integrated across all acquisition phases and programs/teams, to make the realization of the President s vision more certain. Executed properly, SBA will foster better informed, timelier, and more defensible decisions throughout the acquisition life cycle. By doing so, SBA will improve the quality of NASA systems and speed their development, at less cost and risk than would otherwise be the case. SBA is a comprehensive, Enterprise-wide endeavor that necessitates an evolved culture, a revised spiral acquisition process, and an infrastructure of advanced Information Technology (IT) capabilities. SBA encompasses all project phases (from requirements analysis and concept formulation through design, manufacture, training, and operations), professional disciplines, and activities that can benefit from employing SBA capabilities. SBA capabilities include: developing and assessing system concepts and designs; planning manufacturing, assembly, transport, and launch; training crews, maintainers, launch personnel, and controllers; planning and monitoring missions; responding to emergencies by evaluating effects and exploring solutions; and communicating across the OEx
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Schmidt, Greg; Bailey, Brad; Gibbs, Kristina
2015-01-01
The NASA Solar System Exploration Research Virtual Institute (SSERVI) is a virtual institute focused on research at the intersection of science and exploration, training the next generation of lunar scientists, and development and support of the international community. As part of its mission, SSERVI acts as a hub for opportunities that engage the larger scientific and exploration communities in order to form new interdisciplinary, research-focused collaborations. The nine domestic SSERVI teams that comprise the U.S. complement of the Institute engage with the international science and exploration communities through workshops, conferences, online seminars and classes, student exchange programs and internships. SSERVI represents a close collaboration between science, technology and exploration enabling a deeper, integrated understanding of the Moon and other airless bodies as human exploration moves beyond low Earth orbit. SSERVI centers on the scientific aspects of exploration as they pertain to the Moon, Near Earth Asteroids (NEAs) and the moons of Mars, with additional aspects of related technology development, including a major focus on human exploration-enabling efforts such as resolving Strategic Knowledge Gaps (SKGs). The Institute focuses on interdisciplinary, exploration-related science focused on airless bodies targeted as potential human destinations. Areas of study represent the broad spectrum of lunar, NEA, and Martian moon sciences encompassing investigations of the surface, interior, exosphere, and near-space environments as well as science uniquely enabled from these bodies. This research profile integrates investigations of plasma physics, geology/geochemistry, technology integration, solar system origins/evolution, regolith geotechnical properties, analogues, volatiles, ISRU and exploration potential of the target bodies. New opportunities for both domestic and international partnerships are continually generated through these research and
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Exploring Stakeholder Definitions within the Aerospace Industry: A Qualitative Case Study
Hebert, Jonathan R.
A best practice in the discipline of project management is to identify all key project stakeholders prior to the execution of a project. When stakeholders are properly identified, they can be consulted to provide expert advice on project activities so that the project manager can ensure the project stays within the budget and schedule constraints. The problem addressed by this study is that managers fail to properly identify key project stakeholders when using stakeholder theory because there are multiple conflicting definitions for the term stakeholder. Poor stakeholder identification has been linked to multiple negative project outcomes such as budget and schedules overruns, and this problem is heightened in certain industries such as aerospace. The purpose of this qualitative study was to explore project managers' and project stakeholders' perceptions of how they define and use the term stakeholder within the aerospace industry. This qualitative exploratory single-case study had two embedded units of analysis: project managers and project stakeholders. Six aerospace project managers and five aerospace project stakeholders were purposively selected for this study. Data were collected through individual semi-structured interviews with both project managers and project stakeholders. All data were analyzed using Yin's (2011) five-phased cycle approach for qualitative research. The results indicated that the aerospace project managers and project stakeholder define the term stakeholder as "those who do the work of a company." The participants build upon this well-known concept by adding that, "a company should list specific job titles" that correspond to their company specific-stakeholder definition. Results also indicated that the definition of the term stakeholder is used when management is assigning human resources to a project to mitigate or control project risk. Results showed that project managers tended to include the customer in their stakeholder definitions
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NASA Advanced Explorations Systems: Advancements in Life Support Systems
Shull, Sarah A.; Schneider, Walter F.
2016-01-01
The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions assessed by NASA's Habitability Architecture Team (HAT). The LSS project is focused on four areas: architecture and systems engineering for life support systems, environmental monitoring, air revitalization, and wastewater processing and water management. Starting with the international space station (ISS) LSS systems as a point of departure (where applicable), the mission of the LSS project is three-fold: 1. Address discrete LSS technology gaps 2. Improve the reliability of LSS systems 3. Advance LSS systems towards integrated testing on the ISS. This paper summarized the work being done in the four areas listed above to meet these objectives. Details will be given on the following focus areas: Systems Engineering and Architecture- With so many complex systems comprising life support in space, it is important to understand the overall system requirements to define life support system architectures for different space mission classes, ensure that all the components integrate well together and verify that testing is as representative of destination environments as possible. Environmental Monitoring- In an enclosed spacecraft that is constantly operating complex machinery for its own basic functionality as well as science experiments and technology demonstrations, it's possible for the environment to become compromised. While current environmental monitors aboard the ISS will alert crew members and mission control if there is an emergency, long-duration environmental monitoring cannot be done in-orbit as current methodologies
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Several issues of uranium geology exploration facilities decommissioning
International Nuclear Information System (INIS)
Zhang Lu; Lu Caixia; Sheng Qing; Zhuang Jingqi; Xie Shujun; Liao Yunxuan
2013-01-01
The environmental protection completion acceptance review work of uranium geology exploration facilities 'llth five-year plan' decommissioned and remediation projects is introduced. Some questions related to norms and standards for uranium geology exploration facilities decommissioning and remediation, scheme of decommissioning and remediation, process inspection and acceptance of project and so on are discussed, and corresponding countermeasures and suggestions are put forward, Some references can be provided for the later development of uranium geological exploration facility '12th five-year plan' decommissioning and remediation projects. (authors)
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The New National Vision for Space Exploration
Sackheim, Robert L.; Geveden, Rex; King, David A.
2004-01-01
From the Apollo landings on the Moon, to robotic surveys of the Sun and the planets, to the compelling images captured by advanced space telescopes, U.S. achievements in space have revolutionized humanity s view of the universe and have inspired Americans and people around the world. These achievements also have led to the development of technologies that have widespread applications to address problems on Earth. As the world enters the second century of powered flight, it is appropriate to articulate a new vision that will define and guide U.S. space exploration activities for the next several decades. Today, humanity has the potential to seek answers to the most fundamental questions posed about the existence of life beyond Earth. Telescopes have found planets around other stars. Robotic probes have identified potential resources on the Moon, and evidence of water - a key ingredient for life - has been found on Mars and the moons of Jupiter. Direct human experience in space has fundamentally altered our perspective of humanity and our place in the universe. Humans have the ability to respond to the unexpected developments inherent in space travel and possess unique skills that enhance discoveries. Just as Mercury, Gemini, and Apollo challenged a generation of Americans, a renewed U.S. space exploration program with a significant human component can inspire us - and our youth - to greater achievements on Earth and in space. The loss of Space Shuttles Challenger and Columbia and their crews are a stark reminder of the inherent risks of space flight and the severity of the challenges posed by space exploration. In preparation for future human exploration, we must advance our ability to live and work safely in space and, at the same time, develop the technologies to extend humanity s reach to the Moon, Mars, and beyond. The new technologies required for further space exploration also will improve the Nation s other space activities and may provide applications that
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Turning Exploration (R&D) into a Sustainable Business Model
Buskard, James Livingstone
2012-01-01
Nevada Exploration Inc. (“NGE”) is a public exploration company that has developed new technology to identify gold exploration projects in Nevada’s valleys where the bedrock is covered. Covered bedrock settings challenge conventional exploration tools and NGE’s technology represents a significant improvement; however, because the technology is still new, NGE has had a hard time attracting buyers for its projects. Instead, NGE has advanced its exploration targets in house, which has proven cos...
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Methodology for economic evaluation of software development projects
International Nuclear Information System (INIS)
Witte, D.M.
1990-01-01
Many oil and gas exploration and production companies develop computer software in-house or with contract programmers to support their exploration activities. Software development projects compete for funding with exploration and development projects, though most companies lack valid comparison measures for the two types of projects. This paper presents a methodology of pro form a cash flow analysis for software development proposals intended for internal use. This methodology, based on estimates of development and support costs, exploration benefits, and probability of successful development and implementation, can be used to compare proposed software development projects directly with competing exploration proposals
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Ganapathy, Rohan M.
This enthusiastic project describes a long-term development plan to enable human exploration of the outer solar system, with a focus on Europa and Titan. These are two of the most interesting moons of Jupiter and Saturn, respectively, because they are the places in the solar system with the greatest potential for harboring extraterrestrial life. Since human expeditions to these worlds are considered impossible with current capabilities, the proposal of a well-organized sequence of steps towards making this a reality is formulated. The project includes the necessary development strategies in key scientic and technological areas that are essential for identifying the requirements for the exploration of the outer planetary moons. Some of the topics that are analyzed throughout the project plan include: scientic observations at Europa and Titan, advanced propulsion and nuclear power systems, in-situ resource utilization, radiation mitigation techniques, closed life support systems, habitation for long-term space flight, and artificial gravity. In addition to the scientic and technological aspects of this project, it is recognized that before any research and development work may begin, some level of program management must be established. Within this paper, legal issues, national and international policy, motivation, organization and management, economic considerations, outreach, education, ethics, and social implications are all considered with respect to possible future scenarios which enable human missions to the outer solar system. This project illustrates how such accomplishments could influence a mission to Europa to search for evidence of life in its subsurface oceans. The future remains unpredictable, as does the realization of any of these possibilities. However, projects such as this remind us that the final frontier for humans is truly outer space, and only our imagination will determine where the frontier stops. We can dream of visiting other planetary
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Design of Photovoltaic Power System for a Precursor Mission for Human Exploration of Mars
Mcnatt, Jeremiah; Landis, Geoffrey; Fincannon, James
2016-01-01
This project analyzed the viability of a photovoltaic power source for technology demonstration mission to demonstrate Mars in-situ resource utilization (ISRU) to produce propellant for a future human mission, based on technology available within the next ten years. For this assessment, we performed a power-system design study for a scaled ISRU demonstrator lander on the Mars surface based on existing solar array technologies.
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International Planning for Subglacial Lake Exploration
Kennicutt, M.; Priscu, J.
2003-04-01
As one of the last unexplored frontiers on our planet, subglacial lakes offer a unique and exciting venue for exploration and research. Over the past several years, subglacial lakes have captured the imagination of the scientific community and public, evoking images of potential exotic life forms surviving under some of the most extreme conditions on earth. Various planning activities have recognized that due to the remote and harsh conditions, that a successful subglacial lake exploration program will entail a concerted effort for a number of years. It will also require an international commitment of major financial and human resources. To begin a detailed planning process, the Scientific Committee on Antarctic Research (SCAR) convened the Subglacial Antarctic Lake Exploration Group of Specialists (SALEGOS) in Tokyo in 2000. The group was asked to build on previous workshops and meetings to develop a plan to explore subglacial lake environments. Its mandate adopted the guiding principles as agreed in Cambridge in 1999 that the program would be interdisciplinary in scope, be designed for minimum contamination and disturbance of the subglacial lake environment, have as a goal lake entry and sample retrieval, and that the ultimate target of the program should be Lake Vostok exploration. Since its formation SALEGOS has met three times and addressed some of the more intractable issues related to subglacial lake exploration. Topics under discussion include current state-of-the-knowledge of subglacial environments, technological needs, international management and organizational strategies, a portfolio of scientific projects, "clean" requirements, and logistical considerations. In this presentation the actvities of SALEGOS will be summarized and recommendations for an international subglacial lake exploration program discussed.
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Directory of Open Access Journals (Sweden)
Caron Hall
2007-01-01
Full Text Available The Information Technology (IT industry is one that is characterised by rapid change and a heavy reliance on human skills. A study was conducted to qualitatively explore the role of the Human Resource (HR function in the South African IT industry. Semi-structured individual and focus group interviews with professionals in this function highlighted many opportunities for HR to render a more strategic role in an environment where a skills shortage and many related problem areas exist. The implications of these findings are discussed and proposals for redefining the role of HR in the specific industry are offered.
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Lee, Winona K; Harris, Chessa C D; Mortensen, Kawika A; Long, Linsey M; Sugimoto-Matsuda, Jeanelle
2016-05-09
Service learning is endorsed by the Liaison Committee on Medical Education (LCME) as an integral part of U.S. medical school curricula for future physicians. Service learning has been shown to help physicians in training rediscover the altruistic reasons for pursuing medicine and has the potential to enhance students' perspectives of humanism in medicine. The Kalaupapa service learning project is a unique collaboration between disadvantaged post-baccalaureate students with an underserved rural community. This study was conducted to determine whether the Kalaupapa service learning curricula enhanced student perspectives of humanism in medicine at an early stage of their medical training. Program participants between 2008 and 2014 (n = 41) completed written reflections following the conclusion of the service learning project. Four prompts guided student responses. Reflections were thematically analyzed. Once all essays were read, team members compared their findings to condense or expand themes and assess levels of agreement. Emerging themes of resilience and unity were prominent throughout the student reflections. Students expressed respect and empathy for the patients' struggles and strengths, as well as those of their peers. The experience also reinforced students' commitment to service, particularly to populations in rural and underserved communities. Students also gained a deeper understanding of the patient experience and also of themselves as future physicians. To identify and address underserved and rural patients' health care needs, training programs must prepare an altruistic health care workforce that embraces the humanistic element of medicine. The Kalaupapa service learning project is a potential curricular model that can be used to enhance students' awareness and perspectives of humanism in medicine.
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Project-Method Fit: Exploring Factors That Influence Agile Method Use
Young, Diana K.
2013-01-01
While the productivity and quality implications of agile software development methods (SDMs) have been demonstrated, research concerning the project contexts where their use is most appropriate has yielded less definitive results. Most experts agree that agile SDMs are not suited for all project contexts. Several project and team factors have been…
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Perry, Jay L.; Abney, Morgan B.; Knox, James C.; Parrish, Keith J.; Roman, Monserrate C.; Jan, Darrell L.
2012-01-01
Exploring the frontiers of deep space continues to be defined by the technological challenges presented by safely transporting a crew to and from destinations of scientific interest. Living and working on that frontier requires highly reliable and efficient life support systems that employ robust, proven process technologies. The International Space Station (ISS), including its environmental control and life support (ECLS) system, is the platform from which humanity's deep space exploration missions begin. The ISS ECLS system Atmosphere Revitalization (AR) subsystem and environmental monitoring (EM) technical architecture aboard the ISS is evaluated as the starting basis for a developmental effort being conducted by the National Aeronautics and Space Administration (NASA) via the Advanced Exploration Systems (AES) Atmosphere Resource Recovery and Environmental Monitoring (ARREM) Project.. An evolutionary approach is employed by the ARREM project to address the strengths and weaknesses of the ISS AR subsystem and EM equipment, core technologies, and operational approaches to reduce developmental risk, improve functional reliability, and lower lifecycle costs of an ISS-derived subsystem architecture suitable for use for crewed deep space exploration missions. The most promising technical approaches to an ISS-derived subsystem design architecture that incorporates promising core process technology upgrades will be matured through a series of integrated tests and architectural trade studies encompassing expected exploration mission requirements and constraints.
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Molecular biological methods for studying the gut microbiota : the EU human gut flora project
Blaut, M; Collins, MD; Welling, GW; Dore, J; van Loo, J; de Vos, W
Seven European laboratories co-operated in a joint project (FAIR CT97-3035) to develop, refine and apply molecular methods towards facilitating elucidation of the complex composition of the human intestinal microflora and to devise robust methodologies for monitoring the gut flora in response to
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Human Brain Proteome Project - 12th HUPO BPP Workshop. 26 September 2009, Toronto, Canada.
Gröttrup, Bernd; Eisenacher, Martin; Stephan, Christian; Marcus, Katrin; Lee, Bonghee; Meyer, Helmut E; Park, Young Mok
2010-06-01
The HUPO Brain Proteome Project (HUPO BPP) held its 12th workshop in Toronto on 26 September 2009 prior to the HUPO VIII World Congress. The principal aim of this project is to obtain a better understanding of neurodiseases and ageing, with the ultimate objective of discovering prognostic and diagnostic biomarkers, in addition to the development of novel diagnostic techniques and new medications. The attendees came together to discuss progress in the human clinical neuroproteomics and to define the needs and guidelines required for more advanced proteomic approaches.
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Energy Technology Data Exchange (ETDEWEB)
Rasmussen, T.M.; Thorning, L.
2012-09-15
Project ALTKUL was commissioned by DONG E and P A/S and Nordsoefonden; the Danish Energy Agency followed the project closely. The starting point of the study was the need in Danish onshore areas for more knowledge on alternative methods that could be used for hydrocarbon exploration, as an alternative to seismic investigations. DONG E and P A/S and Nordsoefonden approached GEUS, suggesting a study of seven different methods. The Danish Energy Agency was interested in the subject and requested that an actual test of a method be carried out as a part of the project. The seven methods considered and reviewed are: 1: Surface geochemistry; 2: Gravimetric modelling; 3: Magnetotellurics (MT, AMT and ZTEM); 4: High-Moment Electromagnetics (HMEM); 5: High-Powered Spectral Induced Polarization (HPSIP); 6: Electron Para-magnetic Resonance (EPR); 7: Airborne Transient Pulse Surveys. Getting a test of one of the methods based on electromagnetic theory organised caused some difficulties. An experiment with a galvanic controlled source was considered to be the optimum choice. However, based on various contacts and failed attempts to organise a test, a contract was entered with Uppsala University for some initial tests of the MT method. The test is to be carried out in August 2012 and will be reported in a separate report (ALTKUL Project Report Part 2). (LN)
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Energy Technology Data Exchange (ETDEWEB)
Jardi Besa, X.; Munoz Cervantes, A.
2012-07-01
At the onset of nuclear projects in Spain, there was an import of nuclear technology. In a second phase, there was a transfer of technology. Subsequently, there was an adaptation of the technology. In this evolution, comparable to that of other countries, were involved several countries, overcoming the difficulties of human factors involved. The current nuclear projects multinationals have a new difficulty: the different industrial technological environments. This paper will address the organizational challenges of multinational engineering projects, in the type of project and the human factors of the participating companies.
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Call for participation in the neurogenetics consortium within the Human Variome Project.
Haworth, Andrea; Bertram, Lars; Carrera, Paola; Elson, Joanna L; Braastad, Corey D; Cox, Diane W; Cruts, Marc; den Dunnen, Johann T; Farrer, Matthew J; Fink, John K; Hamed, Sherifa A; Houlden, Henry; Johnson, Dennis R; Nuytemans, Karen; Palau, Francesc; Rayan, Dipa L Raja; Robinson, Peter N; Salas, Antonio; Schüle, Birgitt; Sweeney, Mary G; Woods, Michael O; Amigo, Jorge; Cotton, Richard G H; Sobrido, Maria-Jesus
2011-08-01
The rate of DNA variation discovery has accelerated the need to collate, store and interpret the data in a standardised coherent way and is becoming a critical step in maximising the impact of discovery on the understanding and treatment of human disease. This particularly applies to the field of neurology as neurological function is impaired in many human disorders. Furthermore, the field of neurogenetics has been proven to show remarkably complex genotype-to-phenotype relationships. To facilitate the collection of DNA sequence variation pertaining to neurogenetic disorders, we have initiated the "Neurogenetics Consortium" under the umbrella of the Human Variome Project. The Consortium's founding group consisted of basic researchers, clinicians, informaticians and database creators. This report outlines the strategic aims established at the preliminary meetings of the Neurogenetics Consortium and calls for the involvement of the wider neurogenetic community in enabling the development of this important resource.
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The Pioneer Projects - Economical exploration of the solar system
Spahr, J. R.; Hall, C. F.
1975-01-01
The interplanetary Pioneer missions are reviewed in terms of management implications and cost control. The responsibilities, organizational structure, and management practices of the Pioneer Projects are presented. The lines of authority and areas of responsibility of the principal organizational elements supporting the Pioneer missions are identified, and the methods employed for maintaining effective and timely interactions among these elements are indicated. The technical and administrative functions of various organizational elements of the project are described. The management and control of activities prior to and during the hardware procurement phase are described to indicate the basis for obtaining visibility of the technical progress, utilization of resources, and cost performance of the contractors and other institutions supporting the Pioneer projects.
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International Nuclear Information System (INIS)
Goncharova, N.; Butchenkow, I.; Maestri, E.
2016-01-01
Full text: The Joint European TEMPUS Project 'Human Security (environment, quality of food, public health, and society) on Territories Contaminated by Radioactive Agents', started in 2012. The EU project participants are the following: University of Cordoba (Spain) - Project Coordinator, University of Parma (Italy), University of Florence (Italy), Swedish University of Agricultural Sciences (Sweden) and Riga Technical University (Latvia). The project involves three partner countries - Belarus, Russia, Ukraine, represented by the following institutions: Belarusian State University, International Sakharov Environmental University, Grodno State Medical University, Grodno State Agrarian University, Voronezh State University, Tyumen State Medical Academy, Ural Federal University (Yekaterinburg), Chelyabinsk State University, Nuclear Cities Information-Education Centre, Vinnitsa National Medical University, Zhytomyr State Technological University, Kyiv International University, Sevastopol National University of Nuclear Energy and Industry, Polissya branch of G.M. Vysotsky Ukrainian Research Institute of Forestry and Forest Melioration. The main objectives of the project are: to develop interdisciplinary Master and Doctoral (PhD) programs in the field of Human Security of people living in areas affected by accidents at nuclear power plants / plant for processing nuclear fuel within the following specialties: Ecology and Environment Sciences - 'Human Security and Environment'; Food quality control - 'Human Security and Quality of Food'; Medicine - 'Human Security and Public Health'; Political and Social Sciences - 'Human Security and Society'. These programs will be implemented at 12 universities, 4 from each partner country. During the project implementation it is expected to achieve the following main results: modified interdisciplinary Master and Doctoral (PhD) programs taking into account the studied European experience and practice; joint system of upgrade of
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Ammann, C. M.; Brown, B.; Kalb, C. P.; Bullock, R.; Buja, L.; Gutowski, W. J., Jr.; Halley-Gotway, J.; Kaatz, L.; Yates, D. N.
2017-12-01
Coordinated, multi-model climate change projection archives have already led to a flourishing of new climate impact applications. Collections and online tools for the computation of derived indicators have attracted many non-specialist users and decision-makers and facilitated for them the exploration of potential future weather and climate changes on their systems. Guided by a set of standardized steps and analyses, many can now use model output and determine basic model-based changes. But because each application and decision-context is different, the question remains if such a small collection of standardized tools can faithfully and comprehensively represent the critical physical context of change? We use the example of the El Niño - Southern Oscillation, the largest and most broadly recognized mode of variability in the climate system, to explore the difference in impact contexts between a quasi-blind, protocol-bound and a flexible, scientifically guided use of climate information. More use oriented diagnostics of the model-data as well as different strategies for getting data into decision environments are explored.
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NASA In-Situ Resource Utilization (ISRU) Technology and Development Project Overview
Sanders, Gerald B.; Lason, William E.; Sacksteder, Kurt R.; Mclemore, Carole; Johnson, Kenneth
2008-01-01
Since the Vision for Space Exploration (VSE) was released in 2004, NASA, in conjunction with international space agencies, industry, and academia, has continued to define and refine plans for sustained and affordable robotic and human exploration of the Moon and beyond. With the goal of establishing a lunar Outpost on the Moon to extend human presence, pursue scientific activities, use the Moon to prepare for future human missions to Mars, and expand Earth s economic sphere, a change in how space exploration is performed is required. One area that opens up the possibility for the first time of breaking our reliance on Earth supplied consumables and learn to live off the land is In-Situ Resource Utilization (ISRU). ISRU, which involves the extraction and processing of space resources into useful products, can have a substantial impact on mission and architecture concepts. In particular, the ability to make propellants, life support consumables, and fuel cell reagents can significantly reduce the cost, mass, and risk of sustained human activities beyond Earth. However, ISRU is an unproven capability for human lunar exploration and can not be put in the critical path of lunar Outpost success until it has been proven. Therefore, ISRU development and deployment needs to take incremental steps toward the desired end state. To ensure ISRU capabilities are available for pre-Outpost and Outpost deployment by 2020, and mission and architecture planners are confident that ISRU can meet initial and long term mission requirements, the ISRU Project is developing technologies and systems in three critical areas: (1) Regolith Excavation, Handling and Material Transportation; (2) Oxygen Extraction from Regolith; and (3) Volatile Extraction and Resource Prospecting, and in four development stages: (I) Demonstrate feasibility; (II) Evolve system w/ improved technologies; (III) Develop one or more systems to TRL 6 before start of flight development; and (IV) Flight development for
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National Oceanic and Atmospheric Administration (DOC), Rockville, MD.
This activity teaches about the complexity of ocean exploration, the technological applications and capabilities required for ocean exploration, the importance of teamwork in scientific research projects, and developing abilities necessary to do scientific inquiry. The activity provides learning objectives, a list of needed materials, key…
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Applying satellite technology to energy and mineral exploration
Carter, William D.; Rowan, Lawrence C.
1978-01-01
IGCP Project 143 ("Remote Sensing and Mineral Exploration"), is a worldwide research project designed to make satellite data an operational geological tool along with the geologic pick, hand lens, topographic map, aerial photo and geophysical instruments and data that comprise the exploration package. While remote sensing data will not replace field exploration and mapping, careful study of such data prior to field work should make the effort more efficient.
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... cryosections are associated with anatomical terminology. AnatLine : A prototype system consisting of an anatomical image database and ... further information is available Publications VHJOE: Visible Human Journal of Endoscopy. NLM's Current Bibliographies in Medicine, Visible ...
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ispace's Polar Ice Explorer: Commerically Exploring the Poles of the Moon
Calzada-Diaz, A.; Acierno, K.; Rasera, J. N.; Lamamy, J.-A.
2018-04-01
This work provides the background, rationales, and scientific objectives for the ispace Polar Ice Explorer Project, an ISRU exploratory mission that aims to provide data about the lunar polar environment.
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International Nuclear Information System (INIS)
1999-02-01
BP Exploration (Alaska) Inc. (BPXA) submitted a permit application to the US Army Engineer District, Alaska to initiate the review process for BPXA's plans to develop and produce oil and gas from the Northstar Unit. This report contains chapters 8--13 of an Environmental Impact Statement which was undertaken to identify and evaluate the potential effects the proposed project may have on the environment. Attention is focused on the following: effects of oil on the physical, biological, and human environments; effects of noise on the biological and human environments; cumulative effects on the environment; and comparison of project alternatives and their impacts
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The lawful uses of knowledge from the Human Genome Project
Energy Technology Data Exchange (ETDEWEB)
Grad, F.P.
1994-04-15
Part I of this study deals with the right to know or not to know personal genetic information, and examines available legal protections of the right of privacy and the adverse effect of the disclosure of genetic information both on employment and insurance interests and on self esteem and protection of personal integrity. The study examines the rationale for the legal protection of privacy as the protection of a public interest. It examines the very limited protections currently available for privacy interests, including genetic privacy interests, and concludes that there is a need for broader, more far-reaching legal protections. The second part of the study is based on the assumption that as major a project as the Human Genome Project, spending billions of dollars on science which is health related, will indeed be applied for preventive and therapeutic public health purposes, as it has been in the past. It also addresses the recurring fear that public health initiatives in the genetic area must evolve a new eugenic agenda, that we must not repeat the miserable discriminatory experiences of the past.
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Project Management Methodology in Human Resource Management
Josler, Cheryl; Burger, James
2005-01-01
When charged with overseeing a project, how can one ensure that the project will be completed on time, within budget, and to the satisfaction of everyone involved? In this article, the authors examine project management methodology as a means of ensuring that projects are conducted in a disciplined, well-managed and consistent manner that serves…
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Forster, Alice S.; Rockliffe, Lauren; Marlow, Laura A.V.; Bedford, Helen; McBride, Emily; Waller, Jo
2017-01-01
Abstract Objectives In England, uptake of human papillomavirus (HPV) vaccination to prevent HPV‐related cancer is lower among girls from ethnic minority backgrounds. We aimed to explore the factors that prevented ethnic minority parents from vaccinating, compared to White British nonvaccinating parents and vaccinating ethnic minority parents. Methods Interviews with 33 parents (n = 14 ethnic minority non‐vaccinating, n = 10 White British nonvaccinating, and n = 9 ethnic minority vaccinating) ...
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Aurora Mine project - historical resources baseline study
International Nuclear Information System (INIS)
Reeves, B.
1996-01-01
This volume contains the results of a base line archaeological study of the Aurora Mine Project local study area. It was compiled in support of Syncrude Canada's application to the Alberta Energy and Utilities Board (AEUB) and Alberta Environmental Protection to construct and operate it new Aurora Mine, located northeast of Fort McMurray, Alberta. The objective of this study was to compile, consolidate, review and analyze the reports for the area compiled over the past 22 years in and adjacent to the local study area (LSA), particularly those of now existing and Syncrude projects, and previously proposed Alsands and OSLO projects. The report is a summary of the human history in the area including pre-contact native archaeological sites, past archaeological studies, the Hinterland site pattern, post-contact native traditional sites, oil sands exploration/development related sites and paleontological sites in the subject area, and areas adjacent to it. 150 refs., 5 tabs., 43 figs
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Standard development at the Human Variome Project.
Smith, Timothy D; Vihinen, Mauno
2015-01-01
The Human Variome Project (HVP) is a world organization working towards facilitating the collection, curation, interpretation and free and open sharing of genetic variation information. A key component of HVP activities is the development of standards and guidelines. HVP Standards are systems, procedures and technologies that the HVP Consortium has determined must be used by HVP-affiliated data sharing infrastructure and should be used by the broader community. HVP guidelines are considered to be beneficial for HVP affiliated data sharing infrastructure and the broader community to adopt. The HVP also maintains a process for assessing systems, processes and tools that implement HVP Standards and Guidelines. Recommended System Status is an accreditation process designed to encourage the adoption of HVP Standards and Guidelines. Here, we describe the HVP standards development process and discuss the accepted standards, guidelines and recommended systems as well as those under acceptance. Certain HVP Standards and Guidelines are already widely adopted by the community and there are committed users for the others. © The Author(s) 2015. Published by Oxford University Press.
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Delivering below the line in project management – A conceptual exploration
Directory of Open Access Journals (Sweden)
Udechukwu Ojiako
2013-06-01
Design/Methodology/Approach: The study is conceptual in nature and draws upon literature on complexity theory, expectations theories and stakeholder theory. Findings: The paper finds that there is a need to articulate a different assessment of project outcomes than has been traditionally undertaken. Such assessments may emphasise the perceptions of project clients formed through their experience of projects throughout the project lifecycle. Implications: This paper raises questions on whether the outcomes of projects are best ‘measured’ or ‘assessed’.