Relational Discrimination by Pigeons in a Go/No-Go Procedure with Compound Stimuli: A Methodological Note

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Campos, Heloisa Cursi; Debert, Paula; Barros, Romariz da Silva; McIlvane, William J.

2011-01-01

A go/no-go procedure with compound stimuli typically establishes emergent behavior that parallels in structure and typical outcome that of conventional tests for symmetric, transitive, and equivalence relations in normally capable adults. The present study employed a go/no-go compound stimulus procedure with pigeons. During training, pecks to…

GO(vis), a gene ontology visualization tool based on multi-dimensional values.

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Ning, Zi; Jiang, Zhenran

2010-05-01

Most of gene product similarity measurements concentrate on the information content of Gene Ontology (GO) terms or use a path-based similarity between GO terms, which may ignore other important information contained in the structure of the ontology. In our study, we integrate different GO similarity measure approaches to analyze the functional relationship of genes and gene products with a new triangle-based visualization tool called GO(Vis). The purpose of this tool is to demonstrate the effect of three important information factors when measuring the similarity between gene products. One advantage of this tool is that its important ratio can be adjusted to meet different measuring requirements according to the biological knowledge of each factor. The experimental results demonstrate that GO(Vis) can display diagrams of the functional relationship for gene products effectively.

Mental fatigue and impaired response processes: event-related brain potentials in a Go/NoGo task.

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Kato, Yuichiro; Endo, Hiroshi; Kizuka, Tomohiro

2009-05-01

The effects of mental fatigue on the availability of cognitive resources and associated response-related processes were examined using event-related brain potentials. Subjects performed a Go/NoGo task for 60 min. Reaction time, number of errors, and mental fatigue scores all significantly increased with time spent on the task. The NoGo-P3 amplitude significantly decreased with time on task, but the Go-P3 amplitude was not modulated. The amplitude of error-related negativity (Ne/ERN) also decreased with time on task. These results indicate that mental fatigue attenuates resource allocation and error monitoring for NoGo stimuli. The Go- and NoGo-P3 latencies both increased with time on task, indicative of a delay in stimulus evaluation time due to mental fatigue. NoGo-N2 latency increased with time on task, but NoGo-N2 amplitude was not modulated. The amplitude of response-locked lateralized readiness potential (LRP) significantly decreased with time on task. Mental fatigue appears to slows down the time course of response inhibition, and impairs the intensity of response execution.

NuGO contributions to GenePattern

NARCIS (Netherlands)

Groot, de P.J.; Reiff, C.; Mayer, C.; Müller, M.R.

2008-01-01

NuGO, the European Nutrigenomics Organization, utilizes 31 powerful computers for, e.g., data storage and analysis. These so-called black boxes (NBXses) are located at the sites of different partners. NuGO decided to use GenePattern as the preferred genomic analysis tool on each NBX. To handle the

DaGO-Fun: tool for Gene Ontology-based functional analysis using term information content measures.

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Mazandu, Gaston K; Mulder, Nicola J

2013-09-25

The use of Gene Ontology (GO) data in protein analyses have largely contributed to the improved outcomes of these analyses. Several GO semantic similarity measures have been proposed in recent years and provide tools that allow the integration of biological knowledge embedded in the GO structure into different biological analyses. There is a need for a unified tool that provides the scientific community with the opportunity to explore these different GO similarity measure approaches and their biological applications. We have developed DaGO-Fun, an online tool available at http://web.cbio.uct.ac.za/ITGOM, which incorporates many different GO similarity measures for exploring, analyzing and comparing GO terms and proteins within the context of GO. It uses GO data and UniProt proteins with their GO annotations as provided by the Gene Ontology Annotation (GOA) project to precompute GO term information content (IC), enabling rapid response to user queries. The DaGO-Fun online tool presents the advantage of integrating all the relevant IC-based GO similarity measures, including topology- and annotation-based approaches to facilitate effective exploration of these measures, thus enabling users to choose the most relevant approach for their application. Furthermore, this tool includes several biological applications related to GO semantic similarity scores, including the retrieval of genes based on their GO annotations, the clustering of functionally related genes within a set, and term enrichment analysis.

Comparative GO: a web application for comparative gene ontology and gene ontology-based gene selection in bacteria.

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Mario Fruzangohar

Full Text Available The primary means of classifying new functions for genes and proteins relies on Gene Ontology (GO, which defines genes/proteins using a controlled vocabulary in terms of their Molecular Function, Biological Process and Cellular Component. The challenge is to present this information to researchers to compare and discover patterns in multiple datasets using visually comprehensible and user-friendly statistical reports. Importantly, while there are many GO resources available for eukaryotes, there are none suitable for simultaneous, graphical and statistical comparison between multiple datasets. In addition, none of them supports comprehensive resources for bacteria. By using Streptococcus pneumoniae as a model, we identified and collected GO resources including genes, proteins, taxonomy and GO relationships from NCBI, UniProt and GO organisations. Then, we designed database tables in PostgreSQL database server and developed a Java application to extract data from source files and loaded into database automatically. We developed a PHP web application based on Model-View-Control architecture, used a specific data structure as well as current and novel algorithms to estimate GO graphs parameters. We designed different navigation and visualization methods on the graphs and integrated these into graphical reports. This tool is particularly significant when comparing GO groups between multiple samples (including those of pathogenic bacteria from different sources simultaneously. Comparing GO protein distribution among up- or down-regulated genes from different samples can improve understanding of biological pathways, and mechanism(s of infection. It can also aid in the discovery of genes associated with specific function(s for investigation as a novel vaccine or therapeutic targets.http://turing.ersa.edu.au/BacteriaGO.

A smoking-related background helps moderate smokers to focus: An event-related potential study using a Go-NoGo task.

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Detandt, Sandrine; Bazan, Ariane; Schröder, Elisa; Olyff, Giulia; Kajosch, Hendrik; Verbanck, Paul; Campanella, Salvatore

2017-10-01

Cognitive impairment is a major component in addiction. However, research has been inconclusive as to whether this is also the case for smokers. The present study aims at providing electrophysiological clue for altered inhibitory control in smokers and at investigating whether reduced inhibition was more pronounced during exposure to a smoking cue. ERPs were recorded during a visual Go-NoGo task performed by 18 smokers and 23 controls, in which either a frequent Go signal (letter "M") or a rare No-Go signal ("letter W") were superimposed on three different long-lasting background contexts: black-neutral, smoking-related and non smoking-related. (1) Smokers performed worse and had an earlier NoGo-N2 latency as compared to controls and independently of context, suggesting a general inhibition impairment; (2) with smoking-related backgrounds specifically, smokers made fewer mistakes than they did in other contexts and displayed a larger NoGo P3 amplitude. These data might suggest that background cues related to addiction may help smokers to be more accurate in an inhibition task. Our results show the classical inhibitory impairment in smokers as compared to non-smokers. However, our data also suggest that a smoking-related background may bolster the inhibitory ability of smokers specifically. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

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Steinfeld Israel

2009-02-01

Full Text Available Abstract Background Since the inception of the GO annotation project, a variety of tools have been developed that support exploring and searching the GO database. In particular, a variety of tools that perform GO enrichment analysis are currently available. Most of these tools require as input a target set of genes and a background set and seek enrichment in the target set compared to the background set. A few tools also exist that support analyzing ranked lists. The latter typically rely on simulations or on union-bound correction for assigning statistical significance to the results. Results GOrilla is a web-based application that identifies enriched GO terms in ranked lists of genes, without requiring the user to provide explicit target and background sets. This is particularly useful in many typical cases where genomic data may be naturally represented as a ranked list of genes (e.g. by level of expression or of differential expression. GOrilla employs a flexible threshold statistical approach to discover GO terms that are significantly enriched at the top of a ranked gene list. Building on a complete theoretical characterization of the underlying distribution, called mHG, GOrilla computes an exact p-value for the observed enrichment, taking threshold multiple testing into account without the need for simulations. This enables rigorous statistical analysis of thousand of genes and thousands of GO terms in order of seconds. The output of the enrichment analysis is visualized as a hierarchical structure, providing a clear view of the relations between enriched GO terms. Conclusion GOrilla is an efficient GO analysis tool with unique features that make a useful addition to the existing repertoire of GO enrichment tools. GOrilla's unique features and advantages over other threshold free enrichment tools include rigorous statistics, fast running time and an effective graphical representation. GOrilla is publicly available at: http://cbl-gorilla.cs.technion.ac.il

Mastering the game of Go without human knowledge

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Silver, David; Schrittwieser, Julian; Simonyan, Karen; Antonoglou, Ioannis; Huang, Aja; Guez, Arthur; Hubert, Thomas; Baker, Lucas; Lai, Matthew; Bolton, Adrian; Chen, Yutian; Lillicrap, Timothy; Hui, Fan; Sifre, Laurent; van den Driessche, George; Graepel, Thore; Hassabis, Demis

2017-10-01

A long-standing goal of artificial intelligence is an algorithm that learns, tabula rasa, superhuman proficiency in challenging domains. Recently, AlphaGo became the first program to defeat a world champion in the game of Go. The tree search in AlphaGo evaluated positions and selected moves using deep neural networks. These neural networks were trained by supervised learning from human expert moves, and by reinforcement learning from self-play. Here we introduce an algorithm based solely on reinforcement learning, without human data, guidance or domain knowledge beyond game rules. AlphaGo becomes its own teacher: a neural network is trained to predict AlphaGo’s own move selections and also the winner of AlphaGo’s games. This neural network improves the strength of the tree search, resulting in higher quality move selection and stronger self-play in the next iteration. Starting tabula rasa, our new program AlphaGo Zero achieved superhuman performance, winning 100-0 against the previously published, champion-defeating AlphaGo.

Valuation of Go Stimuli or Devaluation of No-Go Stimuli? Evidence of an Increased Preference for Attended Go Stimuli Following a Go/No-Go Task.

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Inoue, Kazuya; Sato, Nobuya

2017-01-01

Attentional inhibition that occurs during discrimination tasks leads to the negative evaluation of distractor stimuli. This phenomenon, known as the distractor devaluation effect also occurs when go/no-go tasks require response inhibition. However, it remains unclear whether there are interactions between attention and response controls when the distractor devaluation effect occurs. The aims of this study were to investigate whether attention to stimuli in the go/no-go task plays a facilitative role in distractor devaluation through response inhibition, and to clarify whether this effect reflects a decreased preference for no-go stimuli. Participants evaluated the preference for pictures before and after a go/no-go task. In Experiments 1 and 2, they made a go or no-go response depending on the category of pictures displayed (gummy candies or rice crackers), whereas in Experiment 3 they did on the basis digit category, even or odd numbers, superimposed on such pictures. Experiments 1 and 2 demonstrated that the pictures presented as no-go stimuli in the preceding go/no-go task were evaluated as less positive than the pictures presented as go stimuli. This devaluation effect reflected an increased preference for the go stimuli but not a decreased preference for the no-go stimuli. Experiment 3 indicated that response inhibition did not affect the preference for the pictures that had not received attention in a preceding go/no-go task. These results suggest that although attention plays an important role in differential ratings for go and no-go stimuli, such differences, in fact, reflect the valuation of go stimuli.

IntelliGO: a new vector-based semantic similarity measure including annotation origin

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Devignes Marie-Dominique

2010-12-01

Full Text Available Abstract Background The Gene Ontology (GO is a well known controlled vocabulary describing the biological process, molecular function and cellular component aspects of gene annotation. It has become a widely used knowledge source in bioinformatics for annotating genes and measuring their semantic similarity. These measures generally involve the GO graph structure, the information content of GO aspects, or a combination of both. However, only a few of the semantic similarity measures described so far can handle GO annotations differently according to their origin (i.e. their evidence codes. Results We present here a new semantic similarity measure called IntelliGO which integrates several complementary properties in a novel vector space model. The coefficients associated with each GO term that annotates a given gene or protein include its information content as well as a customized value for each type of GO evidence code. The generalized cosine similarity measure, used for calculating the dot product between two vectors, has been rigorously adapted to the context of the GO graph. The IntelliGO similarity measure is tested on two benchmark datasets consisting of KEGG pathways and Pfam domains grouped as clans, considering the GO biological process and molecular function terms, respectively, for a total of 683 yeast and human genes and involving more than 67,900 pair-wise comparisons. The ability of the IntelliGO similarity measure to express the biological cohesion of sets of genes compares favourably to four existing similarity measures. For inter-set comparison, it consistently discriminates between distinct sets of genes. Furthermore, the IntelliGO similarity measure allows the influence of weights assigned to evidence codes to be checked. Finally, the results obtained with a complementary reference technique give intermediate but correct correlation values with the sequence similarity, Pfam, and Enzyme classifications when compared to

agriGO v2.0: a GO analysis toolkit for the agricultural community, 2017 update.

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Tian, Tian; Liu, Yue; Yan, Hengyu; You, Qi; Yi, Xin; Du, Zhou; Xu, Wenying; Su, Zhen

2017-07-03

The agriGO platform, which has been serving the scientific community for >10 years, specifically focuses on gene ontology (GO) enrichment analyses of plant and agricultural species. We continuously maintain and update the databases and accommodate the various requests of our global users. Here, we present our updated agriGO that has a largely expanded number of supporting species (394) and datatypes (865). In addition, a larger number of species have been classified into groups covering crops, vegetables, fish, birds and insects closely related to the agricultural community. We further improved the computational efficiency, including the batch analysis and P-value distribution (PVD), and the user-friendliness of the web pages. More visualization features were added to the platform, including SEACOMPARE (cross comparison of singular enrichment analysis), direct acyclic graph (DAG) and Scatter Plots, which can be merged by choosing any significant GO term. The updated platform agriGO v2.0 is now publicly accessible at http://systemsbiology.cau.edu.cn/agriGOv2/. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

A-DaGO-Fun: an adaptable Gene Ontology semantic similarity-based functional analysis tool.

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Mazandu, Gaston K; Chimusa, Emile R; Mbiyavanga, Mamana; Mulder, Nicola J

2016-02-01

Gene Ontology (GO) semantic similarity measures are being used for biological knowledge discovery based on GO annotations by integrating biological information contained in the GO structure into data analyses. To empower users to quickly compute, manipulate and explore these measures, we introduce A-DaGO-Fun (ADaptable Gene Ontology semantic similarity-based Functional analysis). It is a portable software package integrating all known GO information content-based semantic similarity measures and relevant biological applications associated with these measures. A-DaGO-Fun has the advantage not only of handling datasets from the current high-throughput genome-wide applications, but also allowing users to choose the most relevant semantic similarity approach for their biological applications and to adapt a given module to their needs. A-DaGO-Fun is freely available to the research community at http://web.cbio.uct.ac.za/ITGOM/adagofun. It is implemented in Linux using Python under free software (GNU General Public Licence). gmazandu@cbio.uct.ac.za or Nicola.Mulder@uct.ac.za Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

A multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors for functional gene analysis.

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Weber, Kristoffer; Bartsch, Udo; Stocking, Carol; Fehse, Boris

2008-04-01

Functional gene analysis requires the possibility of overexpression, as well as downregulation of one, or ideally several, potentially interacting genes. Lentiviral vectors are well suited for this purpose as they ensure stable expression of complementary DNAs (cDNAs), as well as short-hairpin RNAs (shRNAs), and can efficiently transduce a wide spectrum of cell targets when packaged within the coat proteins of other viruses. Here we introduce a multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors designed according to the "building blocks" principle. Using a wide spectrum of different fluorescent markers, including drug-selectable enhanced green fluorescent protein (eGFP)- and dTomato-blasticidin-S resistance fusion proteins, LeGO vectors allow simultaneous analysis of multiple genes and shRNAs of interest within single, easily identifiable cells. Furthermore, each functional module is flanked by unique cloning sites, ensuring flexibility and individual optimization. The efficacy of these vectors for analyzing multiple genes in a single cell was demonstrated in several different cell types, including hematopoietic, endothelial, and neural stem and progenitor cells, as well as hepatocytes. LeGO vectors thus represent a valuable tool for investigating gene networks using conditional ectopic expression and knock-down approaches simultaneously.

Aspergillus flavus Blast2GO gene ontology database: elevated growth temperature alters amino acid metabolism

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The availability of a representative gene ontology (GO) database is a prerequisite for a successful functional genomics study. Using online Blast2GO resources we constructed a GO database of Aspergillus flavus. Of the predicted total 13,485 A. flavus genes 8,987 were annotated with GO terms. The mea...

GONOME: measuring correlations between GO terms and genomic positions

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Bailey Timothy L

2006-02-01

Full Text Available Abstract Background: Current methods to find significantly under- and over-represented gene ontology (GO terms in a set of genes consider the genes as equally probable "balls in a bag", as may be appropriate for transcripts in micro-array data. However, due to the varying length of genes and intergenic regions, that approach is inappropriate for deciding if any GO terms are correlated with a set of genomic positions. Results: We present an algorithm – GONOME – that can determine which GO terms are significantly associated with a set of genomic positions given a genome annotated with (at least the starts and ends of genes. We show that certain GO terms may appear to be significantly associated with a set of randomly chosen positions in the human genome if gene lengths are not considered, and that these same terms have been reported as significantly over-represented in a number of recent papers. This apparent over-representation disappears when gene lengths are considered, as GONOME does. For example, we show that, when gene length is taken into account, the term "development" is not significantly enriched in genes associated with human CpG islands, in contradiction to a previous report. We further demonstrate the efficacy of GONOME by showing that occurrences of the proteosome-associated control element (PACE upstream activating sequence in the S. cerevisiae genome associate significantly to appropriate GO terms. An extension of this approach yields a whole-genome motif discovery algorithm that allows identification of many other promoter sequences linked to different types of genes, including a large group of previously unknown motifs significantly associated with the terms 'translation' and 'translational elongation'. Conclusion: GONOME is an algorithm that correctly extracts over-represented GO terms from a set of genomic positions. By explicitly considering gene size, GONOME avoids a systematic bias toward GO terms linked to large genes

Distinguishing humans from computers in the game of go: A complex network approach

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Coquidé, C.; Georgeot, B.; Giraud, O.

2017-08-01

We compare complex networks built from the game of go and obtained from databases of human-played games with those obtained from computer-played games. Our investigations show that statistical features of the human-based networks and the computer-based networks differ, and that these differences can be statistically significant on a relatively small number of games using specific estimators. We show that the deterministic or stochastic nature of the computer algorithm playing the game can also be distinguished from these quantities. This can be seen as a tool to implement a Turing-like test for go simulators.

Neurocognitive correlates of processing food-related stimuli in a Go/No-go paradigm.

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Watson, Todd D; Garvey, Katherine T

2013-12-01

We examined the neurocognitive correlates of processing food-related stimuli in healthy young adults. Event-related potential (ERP) data were collected while 48 participants completed a computerized Go/No-go task consisting of food and nonfood images. Separately, we assessed participants' self-reported levels of external, restrained, and emotional eating behaviors as well as trait impulsivity, behavioral activation/inhibition, and performance on the Stroop Color-Word Test. We found that across participants, food images elicited significantly enhanced P3(00) and slow-wave ERP components. The difference in slow-wave components elicited by food and nonfood images was correlated with Stroop interference scores. Food images also elicited significantly enhanced N2(00) components, but only in female participants. The difference between N2 components elicited by food and nonfood images was related to body mass index and scores of external eating in females. Overall, these data suggest that processing food-related stimuli recruits distinct patterns of cortical activity, that the magnitude of these effects is related to behavioral and cognitive variables, and that the neurocognitive correlates of processing food-cues may be at least partly dissociable between males and females. Copyright © 2013 Elsevier Ltd. All rights reserved.

Mechanism of action of a novel human ether-a-go-go-related gene channel activator

DEFF Research Database (Denmark)

Casis, Oscar; Olesen, Søren-Peter; Sanguinetti, Michael C

2005-01-01

depolarizations, NS1643 enhanced the magnitude of wild-type hERG current in a concentration- and voltage-dependent manner with an EC(50) of 10.4 microM at -10 mV. The fully activated current-voltage relationship revealed that the drug increased outward but not inward currents, consistent with altered inactivation...

An Auditory Go/No-Go Study of Event-Related Potentials in Children with Fetal Alcohol Spectrum Disorders

DEFF Research Database (Denmark)

Steinmann, Tobias P.; Andrew, Colin M.; Thomsen, Carsten E.

2011-01-01

Abstract—In this study event-related potentials (ERPs) were used to investigate the effects of prenatal alcohol exposure on response inhibition identified during task performance. ERPs were recorded during a auditory Go/No Go task in two groups of children with mean age of 12:8years (11years to 14......:7years): one diagnosed with fetal alcohol syndrome (FAS) or partial FAS (FAS/PFAS; n = 12) and a control group of children of same age whose mothers abstained from alcohol or drank minimally during pregnancy (n = 11). The children were instructed to push a button in response to the Go stimulus...... trials, suggesting a less efficient early classification of the stimulus. P3 showed larger amplitudes to No-Go vs. Go in both groups. The study has provided new evidence for inhibition deficits in FAS/PFAS subjects identified by ERPs....

The Gene Ontology (GO) Cellular Component Ontology: integration with SAO (Subcellular Anatomy Ontology) and other recent developments

Science.gov (United States)

2013-01-01

Background The Gene Ontology (GO) (http://www.geneontology.org/) contains a set of terms for describing the activity and actions of gene products across all kingdoms of life. Each of these activities is executed in a location within a cell or in the vicinity of a cell. In order to capture this context, the GO includes a sub-ontology called the Cellular Component (CC) ontology (GO-CCO). The primary use of this ontology is for GO annotation, but it has also been used for phenotype annotation, and for the annotation of images. Another ontology with similar scope to the GO-CCO is the Subcellular Anatomy Ontology (SAO), part of the Neuroscience Information Framework Standard (NIFSTD) suite of ontologies. The SAO also covers cell components, but in the domain of neuroscience. Description Recently, the GO-CCO was enriched in content and links to the Biological Process and Molecular Function branches of GO as well as to other ontologies. This was achieved in several ways. We carried out an amalgamation of SAO terms with GO-CCO ones; as a result, nearly 100 new neuroscience-related terms were added to the GO. The GO-CCO also contains relationships to GO Biological Process and Molecular Function terms, as well as connecting to external ontologies such as the Cell Ontology (CL). Terms representing protein complexes in the Protein Ontology (PRO) reference GO-CCO terms for their species-generic counterparts. GO-CCO terms can also be used to search a variety of databases. Conclusions In this publication we provide an overview of the GO-CCO, its overall design, and some recent extensions that make use of additional spatial information. One of the most recent developments of the GO-CCO was the merging in of the SAO, resulting in a single unified ontology designed to serve the needs of GO annotators as well as the specific needs of the neuroscience community. PMID:24093723

The effect of monetary punishment on error evaluation in a Go/No-go task.

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Maruo, Yuya; Sommer, Werner; Masaki, Hiroaki

2017-10-01

Little is known about the effects of the motivational significance of errors in Go/No-go tasks. We investigated the impact of monetary punishment on the error-related negativity (ERN) and error positivity (Pe) for both overt errors and partial errors, that is, no-go trials without overt responses but with covert muscle activities. We compared high and low punishment conditions where errors were penalized with 50 or 5 yen, respectively, and a control condition without monetary consequences for errors. Because we hypothesized that the partial-error ERN might overlap with the no-go N2, we compared ERPs between correct rejections (i.e., successful no-go trials) and partial errors in no-go trials. We also expected that Pe amplitudes should increase with the severity of the penalty for errors. Mean error rates were significantly lower in the high punishment than in the control condition. Monetary punishment did not influence the overt-error ERN and partial-error ERN in no-go trials. The ERN in no-go trials did not differ between partial errors and overt errors; in addition, ERPs for correct rejections in no-go trials without partial errors were of the same size as in go-trial. Therefore the overt-error ERN and the partial-error ERN may share similar error monitoring processes. Monetary punishment increased Pe amplitudes for overt errors, suggesting enhanced error evaluation processes. For partial errors an early Pe was observed, presumably representing inhibition processes. Interestingly, even partial errors elicited the Pe, suggesting that covert erroneous activities could be detected in Go/No-go tasks. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Go-no go monitors

International Nuclear Information System (INIS)

Baxter, P.; Boldeman, J.W.; Delaney, I.

1985-01-01

The IAEA have discussed the need for an NDA instrument to verify that UF 6 production is within the range of declared enrichment at gas centrifuge plants. The instrument must be capable of making a go-nogo decision on whether the enrichment is greater than or less than 20%. It must also be capable of being used during a limited frequency unannounced access inspection of cascade areas. The Go-No Go detector presently being developed uses X-ray spectroscopy to determine the enrichment of the UF 6 gas in the pipework based on the number of the 185.72 KeV gamma rays emitted from the gas

GO Explorer: A gene-ontology tool to aid in the interpretation of shotgun proteomics data.

Science.gov (United States)

Carvalho, Paulo C; Fischer, Juliana Sg; Chen, Emily I; Domont, Gilberto B; Carvalho, Maria Gc; Degrave, Wim M; Yates, John R; Barbosa, Valmir C

2009-02-24

Spectral counting is a shotgun proteomics approach comprising the identification and relative quantitation of thousands of proteins in complex mixtures. However, this strategy generates bewildering amounts of data whose biological interpretation is a challenge. Here we present a new algorithm, termed GO Explorer (GOEx), that leverages the gene ontology (GO) to aid in the interpretation of proteomic data. GOEx stands out because it combines data from protein fold changes with GO over-representation statistics to help draw conclusions. Moreover, it is tightly integrated within the PatternLab for Proteomics project and, thus, lies within a complete computational environment that provides parsers and pattern recognition tools designed for spectral counting. GOEx offers three independent methods to query data: an interactive directed acyclic graph, a specialist mode where key words can be searched, and an automatic search. Its usefulness is demonstrated by applying it to help interpret the effects of perillyl alcohol, a natural chemotherapeutic agent, on glioblastoma multiform cell lines (A172). We used a new multi-surfactant shotgun proteomic strategy and identified more than 2600 proteins; GOEx pinpointed key sets of differentially expressed proteins related to cell cycle, alcohol catabolism, the Ras pathway, apoptosis, and stress response, to name a few. GOEx facilitates organism-specific studies by leveraging GO and providing a rich graphical user interface. It is a simple to use tool, specialized for biologists who wish to analyze spectral counting data from shotgun proteomics. GOEx is available at http://pcarvalho.com/patternlab.

Adaptive strategies for the elderly in inhibiting irrelevant and conflict no-go trials while performing the go/no-go task

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Shulan eHsieh

2016-01-01

Full Text Available This study aimed to differentiate whether or not older adults are more prone to distraction or conflict, as induced by irrelevant and conflict no-go stimuli (irNOGO and cfNOGO, respectively. This study also aimed to determine whether or not older adults would devote more effort to withholding a no-go trial in the higher-control demand condition (20% no-go trials’ probability as compared to the lower-control demand condition (50% and 80% no-go trials’ probability. A total of 96 individuals were recruited, and each of the three no-go trials’ probability conditions included 32 participants (16 younger adults and 16 older adults. Both behavioral and event-related potential (ERP data were measured. The behavioral results showed that the older adults performed more poorly than the younger adults for the go trials, as reflected by slower reaction times and higher numbers of omission errors in the go trials. In contrast, in the no-go trials, the older adults counter-intuitively exhibited similar behavioral performance (i.e., equivalent commission errors as compared to the younger adults. The ERP data further showed that the older adults (but not the younger adults exhibited larger P3 peak amplitudes for the irNOGO than cfNOGO trials. Yet, on the other hand, the older adults performed more poorly (i.e., had more commission errors in the cfNOGO than irNOGO trials. These results seem to suggest that the older adults recruited more control processes in order to conquer the commitment of responses in the no-go trials, especially in the irNOGO trials. This age-related compensatory response of recruiting more control processes was specifically seen in the 20% no-go trial probability condition. This study therefore provides a deeper understanding into how older adults adopt strategies for performing the go/no-go task such as devoting more control processes to inhibiting the irNOGO trials compared to the cfNOGO trials in order to cope with their deficient

BOLD data representing activation and connectivity for rare no-go versus frequent go cues

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Harma Meffert

2016-06-01

Full Text Available The neural circuitry underlying response control is often studied using go/no-go tasks, in which participants are required to respond as fast as possible to go cues and withhold from responding to no-go stimuli. In the current task, response control was studied using a fully counterbalanced design in which blocks with a low frequency of no-go cues (75% go, 25% no-go were alternated with blocks with a low frequency of go cues (25% go, 75% no-go; see also “Segregating attention from response control when performing a motor inhibition task: Segregating attention from response control” [1]. We applied a whole brain corrected, paired t-test to the data assessing for regions differentially activated by low frequency no-go cues relative to high frequency go cues. In addition, we conducted a generalized psychophysiological interaction analysis on the data using a right inferior frontal gyrus seed region. This region was identified through the BOLD response t-test and was chosen because right inferior gyrus is highly implicated in response inhibition.

Event-Related Potentials in a Cued Go-NoGo Task Associated with Executive Functions in Adolescents with Autism Spectrum Disorder; A Case-Control Study

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Anne L. Høyland

2017-07-01

Full Text Available Executive functions are often affected in autism spectrum disorders (ASD. The underlying biology is however not well known. In the DSM-5, ASD is characterized by difficulties in two domains: Social Interaction and Repetitive and Restricted Behavior, RRB. Insistence of Sameness is part of RRB and has been reported related to executive functions. We aimed to identify differences between ASD and typically developing (TD adolescents in Event Related Potentials (ERPs associated with response preparation, conflict monitoring and response inhibition using a cued Go-NoGo paradigm. We also studied the effect of age and emotional content of paradigm related to these ERPs. We investigated 49 individuals with ASD and 49 TD aged 12–21 years, split into two groups below (young and above (old 16 years of age. ASD characteristics were quantified by the Social Communication Questionnaire (SCQ and executive functions were assessed with the Behavior Rating Inventory of Executive Function (BRIEF, both parent-rated. Behavioral performance and ERPs were recorded during a cued visual Go-NoGo task which included neutral pictures (VCPT and pictures of emotional faces (ECPT. The amplitudes of ERPs associated with response preparation, conflict monitoring, and response inhibition were analyzed. The ASD group showed markedly higher scores than TD in both SCQ and BRIEF. Behavioral data showed no case-control differences in either the VCPT or ECPT in the whole group. While there were no significant case-control differences in ERPs from the combined VCPT and ECPT in the whole sample, the Contingent Negative Variation (CNV was significantly enhanced in the old ASD group (p = 0.017. When excluding ASD with comorbid ADHD we found a significantly increased N2 NoGo (p = 0.016 and N2-effect (p = 0.023 for the whole group. We found no case-control differences in the P3-components. Our findings suggest increased response preparation in adolescents with ASD older than 16 years and

Go-no-go performance in pathological gamblers.

Science.gov (United States)

Kertzman, Semion; Lowengrub, Katherine; Aizer, Anat; Vainder, Michael; Kotler, Moshe; Dannon, Pinhas N

2008-10-30

Previous neuropsychological studies demonstrated various deficits of impulse control in pathological gamblers (PGs). However, there are limited data available on response-inhibition impairment among PGs. The present study attempted to assess response inhibition in untreated PGs (N=83), in comparison with normal subjects (N=84). Go/no-go and target-detection conditions of a computerized task were used as a measure of response-inhibition ability. A repeated measures analysis of covariance (ANCOVA-RM) was used with response time, variability of response time, and number of false alarms and misses as dependent measures; group (PG and controls) as the between-subjects measure; condition (target detection or go/no-go) and time slice (first and second in each condition) as repeated measures within-subject factors; and educational level as a covariate. Our results showed that PGs were significantly more impaired in both target detection and go/no-go task performance than controls. The PGs had significantly more false alarms and misses than controls, and they were slower and less consistent in their responses.

Impact of dental fear on oral health-related quality of life among school going and non-school going children in Udaipur city: A cross-sectional study

Directory of Open Access Journals (Sweden)

Akanksha Goyal

2014-01-01

Full Text Available Aim: To assess the impact of dental fear on different domains of oral health-related quality of life (OHRQoL among school going and non-school going children in the Indian scenario. Materials and Methods: The study sample consisted of 279 school children and 257 non-school going children thus making a total sample of 536 children. The sampling frame comprised of 12-15-year-old children attending two upper primary public schools and non-school going children working at shops or not working in Udaipur city, India. Information on dental fear and OHRQoL was obtained by personal interviews by a single trained and calibrated examiner through a structured questionnaire. Intercooled STATA version 9.2 was employed to perform statistical analysis. The level of significance was set at 5%. Results: Mean dental fear scores among school going (35.41 [11.79] and non-school going (47.59 [3.80] children revealed that dental fear was significantly (P ≤ 0.05 higher among non-school going than among school going children. In school going children, the likelihood of having poor oral symptoms, functional limitation and poorer social and emotional well being were significantly (P ≤ 0.05 lesser as compared with non-school going children. Conclusions: Fear has a significant impact on different domains of OHRQoL, except emotional well being, among non-school going children.

Inseparability of Go and Stop in Inhibitory Control: Go Stimulus Discriminability Affects Stopping Behavior

Directory of Open Access Journals (Sweden)

Ning eMa

2016-03-01

Full Text Available Inhibitory control, the ability to stop or modify preplanned actions under changing task conditions, is an important component of cognitive functions. Two lines of models of inhibitory control have previously been proposed for human response in the classical stop-signal task, in which subjects must inhibit a default go response upon presentation of an infrequent stop signal: (1 the race model, which posits two independent go and stop processes that race to determine the behavioral outcome, go or stop; and (2 an optimal decision-making model, which posits that observers decides whether and when to go based on continually (Bayesian updated information about both the go and stop stimuli. In this work, we probe the relationship between go and stop processing by explicitly manipulating the discrimination difficulty of the go stimulus. While the race model assumes the go and stop processes are independent, and therefore go stimulus discriminability should not affect the stop stimulus processing, we simulate the optimal model to show that it predicts harder go discrimination results in a longer go reaction time (RT, a lower stop error rate, as well as a faster stop-signal RT. We then present novel behavioral data that validate these model predictions. The results thus favor a fundamentally inseparable account of go and stop processing, in a manner consistent with the optimal model, and contradicting the independence assumption of the race model. More broadly, our findings contribute to the growing evidence that the computations underlying inhibitory control are systematically modulated by cognitive influences in a Bayes-optimal manner, thus opening new avenues for interpreting neural responses underlying inhibitory control.

GO Explorer: A gene-ontology tool to aid in the interpretation of shotgun proteomics data

Directory of Open Access Journals (Sweden)

Domont Gilberto B

2009-02-01

Full Text Available Abstract Background Spectral counting is a shotgun proteomics approach comprising the identification and relative quantitation of thousands of proteins in complex mixtures. However, this strategy generates bewildering amounts of data whose biological interpretation is a challenge. Results Here we present a new algorithm, termed GO Explorer (GOEx, that leverages the gene ontology (GO to aid in the interpretation of proteomic data. GOEx stands out because it combines data from protein fold changes with GO over-representation statistics to help draw conclusions. Moreover, it is tightly integrated within the PatternLab for Proteomics project and, thus, lies within a complete computational environment that provides parsers and pattern recognition tools designed for spectral counting. GOEx offers three independent methods to query data: an interactive directed acyclic graph, a specialist mode where key words can be searched, and an automatic search. Its usefulness is demonstrated by applying it to help interpret the effects of perillyl alcohol, a natural chemotherapeutic agent, on glioblastoma multiform cell lines (A172. We used a new multi-surfactant shotgun proteomic strategy and identified more than 2600 proteins; GOEx pinpointed key sets of differentially expressed proteins related to cell cycle, alcohol catabolism, the Ras pathway, apoptosis, and stress response, to name a few. Conclusion GOEx facilitates organism-specific studies by leveraging GO and providing a rich graphical user interface. It is a simple to use tool, specialized for biologists who wish to analyze spectral counting data from shotgun proteomics. GOEx is available at http://pcarvalho.com/patternlab.

GO Bus impact analysis.

Science.gov (United States)

2013-08-01

NJ TRANSIT launched two relatively new enhanced bus services: GO 25 serving the : Springfield Avenue corridor in 2008 and GO 28 serving the Bloomfield Avenue corridor in 2009. : As an enhanced but not full Bus Rapid Transit (BRT) service, GO Bus feat...

Inseparability of Go and Stop in Inhibitory Control: Go Stimulus Discriminability Affects Stopping Behavior.

Science.gov (United States)

Ma, Ning; Yu, Angela J

2016-01-01

Inhibitory control, the ability to stop or modify preplanned actions under changing task conditions, is an important component of cognitive functions. Two lines of models of inhibitory control have previously been proposed for human response in the classical stop-signal task, in which subjects must inhibit a default go response upon presentation of an infrequent stop signal: (1) the race model, which posits two independent go and stop processes that race to determine the behavioral outcome, go or stop; and (2) an optimal decision-making model, which posits that observers decides whether and when to go based on continually (Bayesian) updated information about both the go and stop stimuli. In this work, we probe the relationship between go and stop processing by explicitly manipulating the discrimination difficulty of the go stimulus. While the race model assumes the go and stop processes are independent, and therefore go stimulus discriminability should not affect the stop stimulus processing, we simulate the optimal model to show that it predicts harder go discrimination should result in longer go reaction time (RT), lower stop error rate, as well as faster stop-signal RT. We then present novel behavioral data that validate these model predictions. The results thus favor a fundamentally inseparable account of go and stop processing, in a manner consistent with the optimal model, and contradicting the independence assumption of the race model. More broadly, our findings contribute to the growing evidence that the computations underlying inhibitory control are systematically modulated by cognitive influences in a Bayes-optimal manner, thus opening new avenues for interpreting neural responses underlying inhibitory control.

HybridGO-Loc: mining hybrid features on gene ontology for predicting subcellular localization of multi-location proteins.

Science.gov (United States)

Wan, Shibiao; Mak, Man-Wai; Kung, Sun-Yuan

2014-01-01

Protein subcellular localization prediction, as an essential step to elucidate the functions in vivo of proteins and identify drugs targets, has been extensively studied in previous decades. Instead of only determining subcellular localization of single-label proteins, recent studies have focused on predicting both single- and multi-location proteins. Computational methods based on Gene Ontology (GO) have been demonstrated to be superior to methods based on other features. However, existing GO-based methods focus on the occurrences of GO terms and disregard their relationships. This paper proposes a multi-label subcellular-localization predictor, namely HybridGO-Loc, that leverages not only the GO term occurrences but also the inter-term relationships. This is achieved by hybridizing the GO frequencies of occurrences and the semantic similarity between GO terms. Given a protein, a set of GO terms are retrieved by searching against the gene ontology database, using the accession numbers of homologous proteins obtained via BLAST search as the keys. The frequency of GO occurrences and semantic similarity (SS) between GO terms are used to formulate frequency vectors and semantic similarity vectors, respectively, which are subsequently hybridized to construct fusion vectors. An adaptive-decision based multi-label support vector machine (SVM) classifier is proposed to classify the fusion vectors. Experimental results based on recent benchmark datasets and a new dataset containing novel proteins show that the proposed hybrid-feature predictor significantly outperforms predictors based on individual GO features as well as other state-of-the-art predictors. For readers' convenience, the HybridGO-Loc server, which is for predicting virus or plant proteins, is available online at http://bioinfo.eie.polyu.edu.hk/HybridGoServer/.

Lentiviral gene ontology (LeGO) vectors equipped with novel drug-selectable fluorescent proteins: new building blocks for cell marking and multi-gene analysis.

Science.gov (United States)

Weber, K; Mock, U; Petrowitz, B; Bartsch, U; Fehse, B

2010-04-01

Vector-encoded fluorescent proteins (FPs) facilitate unambiguous identification or sorting of gene-modified cells by fluorescence-activated cell sorting (FACS). Exploiting this feature, we have recently developed lentiviral gene ontology (LeGO) vectors (www.LentiGO-Vectors.de) for multi-gene analysis in different target cells. In this study, we extend the LeGO principle by introducing 10 different drug-selectable FPs created by fusing one of the five selection marker (protecting against blasticidin, hygromycin, neomycin, puromycin and zeocin) and one of the five FP genes (Cerulean, eGFP, Venus, dTomato and mCherry). All tested fusion proteins allowed both fluorescence-mediated detection and drug-mediated selection of LeGO-transduced cells. Newly generated codon-optimized hygromycin- and neomycin-resistance genes showed improved expression as compared with their ancestors. New LeGO constructs were produced at titers >10(6) per ml (for non-concentrated supernatants). We show efficient combinatorial marking and selection of various cells, including mesenchymal stem cells, simultaneously transduced with different LeGO constructs. Inclusion of the cytomegalovirus early enhancer/chicken beta-actin promoter into LeGO vectors facilitated robust transgene expression in and selection of neural stem cells and their differentiated progeny. We suppose that the new drug-selectable markers combining advantages of FACS and drug selection are well suited for numerous applications and vector systems. Their inclusion into LeGO vectors opens new possibilities for (stem) cell tracking and functional multi-gene analysis.

Go4Life

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Full Text Available ... now Alzheimer's Disease-Related Dementias: Research Challenges and Opportunities - Duration: 5 minutes, 32 seconds. National Institute On ... This item has been hidden Go4Life Exercises — Building Strength Play all Try some of these Go4Life exercises ...

Theta and Alpha Alterations in Amnestic Mild Cognitive Impairment in Semantic Go/NoGo Tasks

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Lydia T. Nguyen

2017-05-01

Full Text Available Growing evidence suggests that cognitive control processes are impaired in amnestic mild cognitive impairment (aMCI; however the nature of these alterations needs further examination. The current study examined differences in electroencephalographic theta and alpha power related to cognitive control processes involving response execution and response inhibition in 22 individuals with aMCI and 22 age-, sex-, and education-matched cognitively normal controls. Two Go/NoGo tasks involving semantic categorization were used. In the basic categorization task, Go/NoGo responses were made based on exemplars of a single car (Go and a single dog (NoGo. In the superordinate categorization task, responses were made based on multiple exemplars of objects (Go and animals (NoGo. Behavioral data showed that the aMCI group had more false alarms during the NoGo trials compared to controls. The EEG data revealed between group differences related to response type in theta (4–7 Hz and low-frequency alpha (8–10 Hz power. In particular, the aMCI group differed from controls in theta power during the NoGo trials at frontal and parietal electrodes, and in low-frequency alpha power during Go trials at parietal electrodes. These results suggest that alterations in theta power converge with behavioral deterioration in response inhibition, whereas alterations in low-frequency alpha power appear to precede behavioral changes in response execution. Both behavioral and electrophysiological correlates combined provide a more comprehensive characterization of cognitive control deficits in aMCI.

Validation of MIMGO: a method to identify differentially expressed GO terms in a microarray dataset

Directory of Open Access Journals (Sweden)

Yamada Yoichi

2012-12-01

Full Text Available Abstract Background We previously proposed an algorithm for the identification of GO terms that commonly annotate genes whose expression is upregulated or downregulated in some microarray data compared with in other microarray data. We call these “differentially expressed GO terms” and have named the algorithm “matrix-assisted identification method of differentially expressed GO terms” (MIMGO. MIMGO can also identify microarray data in which genes annotated with a differentially expressed GO term are upregulated or downregulated. However, MIMGO has not yet been validated on a real microarray dataset using all available GO terms. Findings We combined Gene Set Enrichment Analysis (GSEA with MIMGO to identify differentially expressed GO terms in a yeast cell cycle microarray dataset. GSEA followed by MIMGO (GSEA + MIMGO correctly identified (p Conclusions MIMGO is a reliable method to identify differentially expressed GO terms comprehensively.

Mastering Go web services

CERN Document Server

Kozyra, Nathan

2015-01-01

If you are a web programmer with experience in developing web services and have a rudimentary knowledge of using Go, then this is the book for you. Basic knowledge of Go as well as knowledge of relational databases and non-relational NoSQL datastores is assumed. Some basic concurrency knowledge is also required.

Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson’s Disease

Science.gov (United States)

Yang, Xue Q.; Lauzon, Brian; Seergobin, Ken N.; MacDonald, Penny A.

2018-01-01

Parkinson’s disease (PD) is characterized by resting tremor, rigidity and bradykinesia. Dopaminergic medications such as L-dopa treat these motor symptoms, but can have complex effects on cognition. Impulse control is an essential cognitive function. Impulsivity is multifaceted in nature. Motor impulsivity involves the inability to withhold pre-potent, automatic, erroneous responses. In contrast, cognitive impulsivity refers to improper risk-reward assessment guiding behavior. Informed by our previous research, we anticipated that dopaminergic therapy would decrease motor impulsivity though it is well known to enhance cognitive impulsivity. We employed the Go/No-go paradigm to assess motor impulsivity in PD. Patients with PD were tested using a Go/No-go task on and off their normal dopaminergic medication. Participants completed cognitive, mood, and physiological measures. PD patients on medication had a significantly higher proportion of Go trial Timeouts (i.e., trials in which Go responses were not completed prior to a deadline of 750 ms) compared to off medication (p = 0.01). No significant ON-OFF differences were found for Go trial or No-go trial response times (RTs), or for number of No-go errors. We interpret that dopaminergic therapy induces a more conservative response set, reflected in Go trial Timeouts in PD patients. In this way, dopaminergic therapy decreased motor impulsivity in PD patients. This is in contrast to the widely recognized effects of dopaminergic therapy on cognitive impulsivity leading in some patients to impulse control disorders. Understanding the nuanced effects of dopaminergic treatment in PD on cognitive functions such as impulse control will clarify therapeutic decisions. PMID:29354045

Going Smokefree Matters - Multiunit Housing Infographic

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U.S. Department of Health & Human Services — Explore the Going Smokefree Matters – Multiunit Housing Infographic which outlines key facts related to the effects of secondhand smoke exposure in multiunit housing.

Validation of MIMGO: a method to identify differentially expressed GO terms in a microarray dataset

OpenAIRE

Yamada, Yoichi; Sawada, Hiroki; Hirotani, Ken-ichi; Oshima, Masanobu; Satou, Kenji

2012-01-01

Abstract Background We previously proposed an algorithm for the identification of GO terms that commonly annotate genes whose expression is upregulated or downregulated in some microarray data compared with in other microarray data. We call these “differentially expressed GO terms” and have named the algorithm “matrix-assisted identification method of differentially expressed GO terms” (MIMGO). MIMGO can also identify microarray data in which genes annotated with a differentially expressed GO...

Go/NoGo performance in boys with Tourette syndrome

DEFF Research Database (Denmark)

Eichele, Heike; Eichele, Tom; Hammar, Asa

2010-01-01

This study compared performance and performance monitoring in 19 boys with Tourette syndrome (TS) (12.64 years, +/- 2.05) and 19 age-matched controls (13.16 years, +/- 2.29) using a Go/NoGo task. The results indicated similar performance accuracy in the TS group and the control group. TS particip......This study compared performance and performance monitoring in 19 boys with Tourette syndrome (TS) (12.64 years, +/- 2.05) and 19 age-matched controls (13.16 years, +/- 2.29) using a Go/NoGo task. The results indicated similar performance accuracy in the TS group and the control group. TS...

Going Smokefree Matters - Multiunit Housing Infographic

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U.S. Department of Health & Human Services — Explore the Going Smokefree Matters – Multiunit Housing Infographic which outlines key facts related to the effects of secondhand smoke exposure in multiunit...

Going Concern eller Concerned Going

DEFF Research Database (Denmark)

Haraszuk, Anni; Hartmann, Stig

2012-01-01

Højsæsonen for revision af årsrapporter 2011 er på trapperne; men hvordan håndterer revisorer egentlig going concern i praksis - i en tid præget af stejle op- og nedture?......Højsæsonen for revision af årsrapporter 2011 er på trapperne; men hvordan håndterer revisorer egentlig going concern i praksis - i en tid præget af stejle op- og nedture?...

Determining Semantically Related Significant Genes.

Science.gov (United States)

Taha, Kamal

2014-01-01

GO relation embodies some aspects of existence dependency. If GO term xis existence-dependent on GO term y, the presence of y implies the presence of x. Therefore, the genes annotated with the function of the GO term y are usually functionally and semantically related to the genes annotated with the function of the GO term x. A large number of gene set enrichment analysis methods have been developed in recent years for analyzing gene sets enrichment. However, most of these methods overlook the structural dependencies between GO terms in GO graph by not considering the concept of existence dependency. We propose in this paper a biological search engine called RSGSearch that identifies enriched sets of genes annotated with different functions using the concept of existence dependency. We observe that GO term xcannot be existence-dependent on GO term y, if x- and y- have the same specificity (biological characteristics). After encoding into a numeric format the contributions of GO terms annotating target genes to the semantics of their lowest common ancestors (LCAs), RSGSearch uses microarray experiment to identify the most significant LCA that annotates the result genes. We evaluated RSGSearch experimentally and compared it with five gene set enrichment systems. Results showed marked improvement.

Artificial intelligence: Learning to play Go from scratch

Science.gov (United States)

Singh, Satinder; Okun, Andy; Jackson, Andrew

2017-10-01

An artificial-intelligence program called AlphaGo Zero has mastered the game of Go without any human data or guidance. A computer scientist and two members of the American Go Association discuss the implications. See Article p.354

Male Smokers' and Non-Smokers' Response Inhibition in Go/No-Go Tasks: Effect of Three Task Parameters

Science.gov (United States)

Zhao, Xin; Liu, Xiaoting; Zan, Xiangyi; Jin, Ge; Maes, Joseph H. R.

2016-01-01

Impaired response inhibition plays a major role in many addictive behaviors. However, in studies using go/no-go tasks, findings regarding the presence of response inhibition deficits in nicotine-dependent individuals are mixed. This might be due to differences between studies on a number of task parameters. Here we aimed to identify task conditions under which go/no-go task performance deficits can be observed in smokers and to characterize the nature of such deficits. Sixty-one male students (30 smokers, 31 non-smokers) performed a go/no-go task while independently manipulating three task parameters: (1) percentage no-go trials (50% or 25%), (2) stimulus presentation time (600 ms or 200 ms), and (3) nature of no-go stimuli (cigarette related or cigarette unrelated). Three measures, reaction time on go trials and percentage correct responses on go and no-go trials, served as performance indicators. Under 200-ms but not 600-ms stimulus presentation conditions, the smokers responded faster on go trials and made more errors on both go and no-go trials than the non-smokers did. These differences occurred irrespective of the percentage of no-go trials and nature of no-go stimuli. The accuracy differences disappeared after controlling for the response time differences, suggesting a strong speed-accuracy trade-off. This study contributes to unraveling the conditions under which smokers display impaired inhibition performance and helps to characterize the nature of this impairment. Under task conditions prompting fast responding, smokers are more prone to increase response speed and to make more errors than non-smokers. PMID:27500831

Using GO-WAR for mining cross-ontology weighted association rules.

Science.gov (United States)

Agapito, Giuseppe; Cannataro, Mario; Guzzi, Pietro Hiram; Milano, Marianna

2015-07-01

The Gene Ontology (GO) is a structured repository of concepts (GO terms) that are associated to one or more gene products. The process of association is referred to as annotation. The relevance and the specificity of both GO terms and annotations are evaluated by a measure defined as information content (IC). The analysis of annotated data is thus an important challenge for bioinformatics. There exist different approaches of analysis. From those, the use of association rules (AR) may provide useful knowledge, and it has been used in some applications, e.g. improving the quality of annotations. Nevertheless classical association rules algorithms do not take into account the source of annotation nor the importance yielding to the generation of candidate rules with low IC. This paper presents GO-WAR (Gene Ontology-based Weighted Association Rules) a methodology for extracting weighted association rules. GO-WAR can extract association rules with a high level of IC without loss of support and confidence from a dataset of annotated data. A case study on using of GO-WAR on publicly available GO annotation datasets is used to demonstrate that our method outperforms current state of the art approaches. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Redundancy gains in simple responses and go/no-go tasks

DEFF Research Database (Denmark)

Gondan, Matthias; Götze, C.; Greenlee, M.W.

2010-01-01

In divided-attention tasks with two classes of target stimuli, participants typically respond more quickly if both targets are presented simultaneously, as compared with single-target presentation (redundant-signals effect). Different explanations exist for this effect, including serial, parallel...... times in both the simple and go/no-go responses were well explained by a common coactivation model assuming linear superposition of modality-specific activation. In Experiment 2, the go/no-go task was made more difficult. Participants had to respond to high-frequency tones or right-tilted Gabor patches...

NoGOA: predicting noisy GO annotations using evidences and sparse representation.

Science.gov (United States)

Yu, Guoxian; Lu, Chang; Wang, Jun

2017-07-21

Gene Ontology (GO) is a community effort to represent functional features of gene products. GO annotations (GOA) provide functional associations between GO terms and gene products. Due to resources limitation, only a small portion of annotations are manually checked by curators, and the others are electronically inferred. Although quality control techniques have been applied to ensure the quality of annotations, the community consistently report that there are still considerable noisy (or incorrect) annotations. Given the wide application of annotations, however, how to identify noisy annotations is an important but yet seldom studied open problem. We introduce a novel approach called NoGOA to predict noisy annotations. NoGOA applies sparse representation on the gene-term association matrix to reduce the impact of noisy annotations, and takes advantage of sparse representation coefficients to measure the semantic similarity between genes. Secondly, it preliminarily predicts noisy annotations of a gene based on aggregated votes from semantic neighborhood genes of that gene. Next, NoGOA estimates the ratio of noisy annotations for each evidence code based on direct annotations in GOA files archived on different periods, and then weights entries of the association matrix via estimated ratios and propagates weights to ancestors of direct annotations using GO hierarchy. Finally, it integrates evidence-weighted association matrix and aggregated votes to predict noisy annotations. Experiments on archived GOA files of six model species (H. sapiens, A. thaliana, S. cerevisiae, G. gallus, B. Taurus and M. musculus) demonstrate that NoGOA achieves significantly better results than other related methods and removing noisy annotations improves the performance of gene function prediction. The comparative study justifies the effectiveness of integrating evidence codes with sparse representation for predicting noisy GO annotations. Codes and datasets are available at http://mlda.swu.edu.cn/codes.php?name=NoGOA .

Upaya Peningkatkan Brand Awareness PT. Go-Jek Indonesia Melalui Aktivitas Marketing Public Relations

Directory of Open Access Journals (Sweden)

Umaimah Wahid

2017-07-01

Full Text Available Online transportation is nowadays popular in Indonesia and becomes a new alternative for people due to its efficiency and effectivity. One of the most famous online transportations is PT.Go-Jek Indonesia. People prefer to choose it to anticipate traffic jam in Jakarta and the surroundings. Besides PT. Go-Jek, there are some similar transportations such as PT.GRAB, UBER, and so on. This condition caused the competition among the online transportations resulting in the necessity to create a strong brand around the people. In accordance to that matter, the role of public relation is quite significant to increase Brand awareness in society. This research focus on the role of public relations to increase the brand awareness of PT Go-Jek using the theory of mixed public relation strategy by Thomas L. Harris that is famous of his concept, ‘P.E.N.C.I.L.S’. The method of this research is case study by interview completed by data as data collection technique. The activity of public relations involves the 7 strategies of public relation to increase brand awareness. The activities were for example publication, holding interesting events, establishing good relationship with society, cooperating with other companies, creating a positive image, providing services and new features for the society. Those are meant to show that PT. GO-JEK gives the best service for customers and society to strengthen the brand awareness of PT. Go-Jek. Those efforts of PT Go-Jek resulted in increasing the brand awareness so that society chooses that online transportation as an alternative of nowadays internet-based transformation. Transportasi online saat ini marak di Indonesia dan menjadi alternatif baru bagi masyarakat karena efisien dan efektif. Salah satu transportasi online yang fenomena adalah PT. Go-Jek Indonesia yang menjadi pilihan masyarakat dalam mengantisipasi kemacetan Jakarta dan sekitarnya. Selain PT. Go-Jek, terdapat beberapa transportasi sejenis lannya yang

Going Smokefree Matters - Bars and Restaurants Infographic

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U.S. Department of Health & Human Services — Explore the Going Smokefree Matters – Bars and Restaurants Infographic which outlines key facts related to the effects of secondhand smoke exposure in bars and...

Going Smokefree Matters - In Your Home Infographic

Data.gov (United States)

U.S. Department of Health & Human Services — Explore the Going Smokefree Matters – In Your Home Infographic which outlines key facts related to the effects of secondhand smoke exposure in the home.

Go4Life

Medline Plus

Full Text Available ... some of these Go4Life exercises to improve your flexibility! 2:48 Play next Play now Go4Life Exercise-- ... 17,679 views Exercise your upper body at work like Linda with Go4Life's Wall Pushups. CC 1: ...

Going Smokefree Matters - Bars and Restaurants Infographic

Data.gov (United States)

U.S. Department of Health & Human Services — Explore the Going Smokefree Matters – Bars and Restaurants Infographic which outlines key facts related to the effects of secondhand smoke exposure in bars and...

Go4Life

Medline Plus

Full Text Available ... Go4Life Exercises — Stretching Play all Try some of these Go4Life exercises to improve your flexibility! 2:48 ... Exercises — Building Strength Play all Try some of these Go4Life exercises to improve your strength! Stronger muscles ...

Machine learning in Go : Supervised learning of move prediction

NARCIS (Netherlands)

de Groote, E.

2005-01-01

The oriental game of Go is increasingly recognized as the "grand challenge" of Artificial Intelligence (AI). So far, traditional AI approaches have resulted in programs that play at the level of a human amateur. Engineering Go knowledge into a Go playing program has proven to be a difficult task, a

Threat engagement, disengagement, and sensitivity bias in worry-prone individuals as measured by an emotional go/no-go task.

Science.gov (United States)

Gole, Markus; Köchel, Angelika; Schäfer, Axel; Schienle, Anne

2012-03-01

The goal of the present study was to investigate a threat engagement, disengagement, and sensitivity bias in individuals suffering from pathological worry. Twenty participants high in worry proneness and 16 control participants low in worry proneness completed an emotional go/no-go task with worry-related threat words and neutral words. Shorter reaction times (i.e., threat engagement bias), smaller omission error rates (i.e., threat sensitivity bias), and larger commission error rates (i.e., threat disengagement bias) emerged only in the high worry group when worry-related words constituted the go-stimuli and neutral words the no-go stimuli. Also, smaller omission error rates as well as larger commission error rates were observed in the high worry group relative to the low worry group when worry-related go stimuli and neutral no-go stimuli were used. The obtained results await further replication within a generalized anxiety disorder sample. Also, further samples should include men as well. Our data suggest that worry-prone individuals are threat-sensitive, engage more rapidly with aversion, and disengage harder. Copyright © 2011 Elsevier Ltd. All rights reserved.

Go/NoGo performance in boys with Tourette syndrome

DEFF Research Database (Denmark)

Eichele, Heike; Eichele, Tom; Hammar, Asa

2010-01-01

This study compared performance and performance monitoring in 19 boys with Tourette syndrome (TS) (12.64 years, +/- 2.05) and 19 age-matched controls (13.16 years, +/- 2.29) using a Go/NoGo task. The results indicated similar performance accuracy in the TS group and the control group. TS particip...

A Go/No-go approach to uncovering implicit attitudes towards safe and risky driving

DEFF Research Database (Denmark)

Martinussen, Laila Marianne; Sømhovd, Mikael J.; Møller, Mette

2015-01-01

Self-report measures of driving-related attitudes and beliefs miss potentially important precursors of driving behaviour, namely, automatic and implicit thought processes. The present study used an adapted Go/No-go Association Task to measure implicit thought without relying on the participants......' self-reports. Implicit attitudes towards safe and risky driving were measured in 53 Danish drivers (31 female, 22 male). Further, we explored the relationship between implicit attitudes towards risky and safe driving, and self-reported driving behaviour and skills. The results suggest that implicit...... attitudes were significantly related to self-reported driving behaviour and skills for male (but not female) drivers. Pending future research with larger sample sizes, the difference between implicit attitudes towards safe versus risky driving that we observed may contribute to a greater theoretical...

Go programming blueprints

CERN Document Server

Ryer, Mat

2015-01-01

Intended for seasoned Go programmers who want to put their expertise in Go to use to solve big, real-world, modern problems. With a basic understanding of channels and goroutines, you will hone your skills to build tools and programs that are quick and simple. You need not be an expert in distributed systems or technologies in order to deliver solutions capable of great scale. It is assumed that you are familiar with the basic concepts of Go.

Go/no-go discriminated avoidance learning in prenatally x-irradiated rats

International Nuclear Information System (INIS)

Tamaki, Y.; Inouye, M.

1988-01-01

Male Fischer344 rats were exposed to x-irradiation at a dose of 200 rad on Day 17 of gestation. Irradiated and control rats were tested at 10-13 weeks of age with the paradigm of go/no-go (active-passive) discriminated avoidance conditioning for three consecutive daily sessions. During the first conditioning session, they learned only active avoidance responses to two different warning signals. During the second and third sessions, they learned active and passive avoidance responses: in response to one warning signal, rats were required to make an active response to avoid a shock, but not to run in response to the other signal in order to avoid a shock. Prenatally irradiated rats made more active avoidance responses to both warning signals than controls (first session). In the early training phase of the go/no-go task, irradiated rats performed significantly higher active and lower passive avoidance responses than controls. Irradiated rats established a strong tendency to respond actively to the no-go signal, but eventually learned to respond to it

The effect of an advisory system on pilots' go/no-go decision during take-off

DEFF Research Database (Denmark)

Bove, T.; Andersen, H.B.

2002-01-01

The take-off phase of modem airliners is a relatively critical phase of flight. Thus, about 12% of all civil aviation accidents happen during take-off. In this paper we describe results of an experimental study of a prototype cockpit advisory take-off monitoring system designed to help pilots...... to make better and safer go/no-go decisions in the case of abnormal events during take-off. We describe, first, the basic aspects of the take-off task and, second, some of the information processing and risk assessment problems involved in making go/no-go decisions at high speeds during take-off. Third......, we describe a prototype advisory take-off monitoring system (ATOMS), which as the result of a research project, has been designed to improve pilots' judgement of acceleration and deceleration during the take-off roll. Fourth, we report on results of an experimental study of this prototype system...

Relational Leading – Appreciating Letting Go, and Not Knowing Where You Are Going

DEFF Research Database (Denmark)

Larsen, Mette Vinther

2016-01-01

In this article we meet Steven,the manager of a Danish regional regional medical supply organization. With him, we explore how – even for leaders – it can feel liberating to let go of existing knowledge and understanding and embark on a journey with others with the certainty that no one knows where...

A novel variable delay Go/No-Go task to study attention, motivation and working memory in the head-fixed rodent.

Science.gov (United States)

Dolzani, Samuel D; Nakamura, Shinya; Cooper, Donald C

2013-01-01

In order to parse the causal elements underlying complex behaviors and decision-making processes, appropriate behavioral methods must be developed and used in concurrence with molecular, pharmacological, and electrophysiological approaches. Presented is a protocol for a novel Go/No-Go behavioral paradigm to study the brain attention and motivation/reward circuitry in awake, head-restrained rodents. This experimental setup allows: (1) Pharmacological and viral manipulation of various brain regions via targeted guide cannula; (2) Optogenetic cell-type specific activation and silencing with simultaneous electrophysiological recording and; (3) Repeated electrophysiological single and multiple unit recordings during ongoing behavior. The task consists of three components. The subject first makes an observing response by initiating a trial by lever pressing in response to distinctive Go or No-Go tones.  Then, after a variable delay period, the subject is presented with a challenge period cued by white noise during which they must respond with a lever press for the Go condition or withhold from lever pressing for the duration of the cue in the No-Go condition. After correctly responding during the challenge period (Challenge) and a brief delay, a final reward tone of the same frequency as the initiation tone is presented and sucrose reward delivery is available and contingent upon lever pressing. Here, we provide a novel procedure and validating data set that allows researchers to study and manipulate components of behavior such as attention, motivation, impulsivity, and reward-related working memory during an ongoing operant behavioral task while limiting interference from non task-related behaviors.

Evaluation of GO-based functional similarity measures using S. cerevisiae protein interaction and expression profile data

Directory of Open Access Journals (Sweden)

Du LinFang

2008-11-01

Full Text Available Abstract Background Researchers interested in analysing the expression patterns of functionally related genes usually hope to improve the accuracy of their results beyond the boundaries of currently available experimental data. Gene ontology (GO data provides a novel way to measure the functional relationship between gene products. Many approaches have been reported for calculating the similarities between two GO terms, known as semantic similarities. However, biologists are more interested in the relationship between gene products than in the scores linking the GO terms. To highlight the relationships among genes, recent studies have focused on functional similarities. Results In this study, we evaluated five functional similarity methods using both protein-protein interaction (PPI and expression data of S. cerevisiae. The receiver operating characteristics (ROC and correlation coefficient analysis of these methods showed that the maximum method outperformed the other methods. Statistical comparison of multiple- and single-term annotated proteins in biological process ontology indicated that genes with multiple GO terms may be more reliable for separating true positives from noise. Conclusion This study demonstrated the reliability of current approaches that elevate the similarity of GO terms to the similarity of proteins. Suggestions for further improvements in functional similarity analysis are also provided.

GOMA: functional enrichment analysis tool based on GO modules

Institute of Scientific and Technical Information of China (English)

Qiang Huang; Ling-Yun Wu; Yong Wang; Xiang-Sun Zhang

2013-01-01

Analyzing the function of gene sets is a critical step in interpreting the results of high-throughput experiments in systems biology.A variety of enrichment analysis tools have been developed in recent years,but most output a long list of significantly enriched terms that are often redundant,making it difficult to extract the most meaningful functions.In this paper,we present GOMA,a novel enrichment analysis method based on the new concept of enriched functional Gene Ontology (GO) modules.With this method,we systematically revealed functional GO modules,i.e.,groups of functionally similar GO terms,via an optimization model and then ranked them by enrichment scores.Our new method simplifies enrichment analysis results by reducing redundancy,thereby preventing inconsistent enrichment results among functionally similar terms and providing more biologically meaningful results.

Metal Free Graphene Oxide (GO) Nanosheets and Pristine-Single Wall Carbon Nanotubes (p-SWCNTs) Biocompatibility Investigation: A Comparative Study in Different Human Cell Lines.

Science.gov (United States)

Valentini, Federica; Mari, Emanuela; Zicari, Alessandra; Calcaterra, Andrea; Talamo, Maurizio; Scioli, Maria Giovanna; Orlandi, Augusto; Mardente, Stefania

2018-04-28

The in vitro biocompatibility of Graphene Oxide (GO) nanosheets, which were obtained by the electrochemical exfoliation of graphite electrodes in an electrolytic bath containing salts, was compared with the pristine Single Wall Carbon Nanotubes (p-SWCNTs) under the same experimental conditions in different human cell lines. The cells were treated with different concentrations of GO and SWCNTs for up to 48 h. GO did not induce any significant morphological or functional modifications (demonstrating a high biocompatibility), while SWNCTs were toxic at any concentration used after a few hours of treatment. The cell viability or cytotoxicity were detected by the trypan blue assay and the lactate dehydrogenase LDH quantitative enzymatic test. The Confocal Laser Scanning Microscopy (CLSM) and transmission electron microscopy (TEM) analysis demonstrated the uptake and internalization of GO sheets into cells, which was localized mainly in the cytoplasm. Different results were observed in the same cell lines treated with p-SWCNTs. TEM and CLSM (Confocal Laser Scanning Microscopy) showed that the p-SWCNTs induced vacuolization in the cytoplasm, disruption of cellular architecture and damage to the nuclei. The most important result of this study is our finding of a higher GO biocompatibility compared to the p-SWCNTs in the same cell lines. This means that GO nanosheets, which are obtained by the electrochemical exfoliation of a graphite-based electrode (carried out in saline solutions or other physiological working media) could represent an eligible nanocarrier for drug delivery, gene transfection and molecular cell imaging tests.

Long QT 1 mutation KCNQ1A344V increases local anesthetic sensitivity of the slowly activating delayed rectifier potassium current

DEFF Research Database (Denmark)

Siebrands, Cornelia C; Binder, Stephan; Eckhoff, Ulrike

2006-01-01

BACKGROUND: Anesthesia in patients with long QT syndrome (LQTS) is a matter of concern. Congenital LQTS is most frequently caused by mutations in KCNQ1 (Kv7.1), whereas drug-induced LQTS is a consequence of HERG (human ether-a-go-go-related gene) channel inhibition. The aim of this study was to i...

Go4Life

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Full Text Available ... useful upper body exercise from Go4Life, the Overhead Arm Raise. CC 3:10 Play next Play now Go4Life Exercise--Hand Grip - Duration: 3 minutes, 10 seconds. National Institute ...

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Full Text Available ... This item has been hidden Go4Life Exercises — Building Strength Play all Try some of these Go4Life exercises to improve your strength! Stronger muscles can make it easier to do ...

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Full Text Available ... more This item has been hidden Go4Life Exercises — Balance Play all Try some of these Go4Life exercises to improve your balance! Balance is important because it can help reduce ...

The development of automatic emotion regulation in an implicit emotional Go/NoGo paradigm and the association with depressive symptoms and anhedonia during adolescence

Directory of Open Access Journals (Sweden)

Wenhai Zhang

2016-01-01

Full Text Available Impaired automatic emotion regulation (AER is closely related to major depressive disorder. Our research in adults has identified two AER-related components, Go N2 and NoGo P3, in an implicit emotional Go/NoGo paradigm. However, it is unclear whether Go N2 and NoGo P3 reflect the development of AER in adolescents and the relationship of these components with subclinical depressive symptoms and trait anhedonia. We collected EEG data from 55 adolescents while they completed the implicit emotional Go/NoGo task. After the experiment, the subjects completed the Chinese version of the Temporal Experience of Pleasure Scale and the Beck Depression Inventory. Consistent with results in adults, we determined that Go N2 represents automatic top-down attention to emotions in Go trials, whereas NoGo P3 represents automatic response inhibition in NoGo trials. These AER components exhibited age-dependent improvement during adolescence. Additionally, NoGo P3 amplitudes elicited by viewing positive faces were positively correlated with trait anhedonia, whereas NoGo P3 amplitudes elicited by viewing negative faces were negatively correlated with depressive symptoms. Our observations provide further understanding of the neurodevelopmental mechanism of AER and yield new insight into dissociable impairments in AER in adolescents with major depressive disorder during positive and negative implicit processing.

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Full Text Available ... years ago 17,529 views Exercise your upper body at work like Linda with Go4Life's Wall Pushups. ... Trainer Sandy shows Linda how to do lower body exercises in her office with Go4Life's Toe Stand. ...

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Full Text Available ... all Try some of these Go4Life exercises to improve your flexibility! 2:48 Play next Play now ... all Try some of these Go4Life exercises to improve your strength! Stronger muscles can make it easier ...

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Full Text Available ... Go4Life exercises to improve your strength! Stronger muscles can make it easier to do everyday things like ... 513 views Trainer Sandy shows Irene that you can do Go4Life exercises anywhere, even the kitchen! CC ...

Chinese Entrepreneurs Go Global

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Daniel Zhou

2012-02-01

Full Text Available China may be on the tipping point of explosive global growth. In response to changes in the global economy and an economic slowdown domestically, hundreds of thousands of Chinese SMEs are being encouraged to “go global” by their central and local governments. To a Chinese company, going global requires the expansion of its existing business in other countries or the development of new ventures with partners operating in other countries. Explosive growth in China may be possible, but it will depend on an appropriate strategy for going global. For a country that has firmly established itself as an international manufacturing hub, going global requires a shift in its entrepreneurial capacity, which is the focus of this article. We first assess the current situation in China to understand its current entrepreneurial focus and capacity, as well as the impetus for change. Next, we contrast the Kirznerian and Schumpeterian views of entrepreneurship to illustrate that – to go global – Chinese entrepreneurs must shift from an emphasis on exploiting pricing inefficiencies (i.e., Kirznerian entrepreneurship to an emphasis on innovation (i.e., Schumpeterian entrepreneurship. Finally, we examine unique characteristics of the business environment and culture in China, which are likely to impact the ability of Chinese entrepreneurs to go global.

Go4Life

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Full Text Available ... Red Get YouTube TV Best of YouTube Music Sports Gaming Movies TV Shows News Live Spotlight 360° ... more This item has been hidden Go4Life Exercises — Balance Play all Try some of these Go4Life exercises ...

Mastering the game of Go with deep neural networks and tree search

Science.gov (United States)

Silver, David; Huang, Aja; Maddison, Chris J.; Guez, Arthur; Sifre, Laurent; van den Driessche, George; Schrittwieser, Julian; Antonoglou, Ioannis; Panneershelvam, Veda; Lanctot, Marc; Dieleman, Sander; Grewe, Dominik; Nham, John; Kalchbrenner, Nal; Sutskever, Ilya; Lillicrap, Timothy; Leach, Madeleine; Kavukcuoglu, Koray; Graepel, Thore; Hassabis, Demis

2016-01-01

The game of Go has long been viewed as the most challenging of classic games for artificial intelligence owing to its enormous search space and the difficulty of evaluating board positions and moves. Here we introduce a new approach to computer Go that uses ‘value networks’ to evaluate board positions and ‘policy networks’ to select moves. These deep neural networks are trained by a novel combination of supervised learning from human expert games, and reinforcement learning from games of self-play. Without any lookahead search, the neural networks play Go at the level of state-of-the-art Monte Carlo tree search programs that simulate thousands of random games of self-play. We also introduce a new search algorithm that combines Monte Carlo simulation with value and policy networks. Using this search algorithm, our program AlphaGo achieved a 99.8% winning rate against other Go programs, and defeated the human European Go champion by 5 games to 0. This is the first time that a computer program has defeated a human professional player in the full-sized game of Go, a feat previously thought to be at least a decade away.

Trait impulsivity and impaired prefrontal impulse inhibition function in adolescents with internet gaming addiction revealed by a Go/No-Go fMRI study.

Science.gov (United States)

Ding, Wei-na; Sun, Jin-hua; Sun, Ya-Wen; Chen, Xue; Zhou, Yan; Zhuang, Zhi-guo; Li, Lei; Zhang, Yong; Xu, Jian-rong; Du, Ya-song

2014-05-30

Recent studies suggest that Internet gaming addiction (IGA) is an impulse disorder, or is at least related to impulse control disorders. In the present study, we hypothesized that different facets of trait impulsivity may be specifically linked to the brain regions with impaired impulse inhibition function in IGA adolescents. Seventeen adolescents with IGA and seventeen healthy controls were scanned during performance of a response-inhibition Go/No-Go task using a 3.0 T MRI scanner. The Barratt Impulsiveness Scale (BIS)-11 was used to assess impulsivity. There were no differences in the behavioral performance on the Go/No-Go task between the groups. However, the IGA group was significantly hyperactive during No-Go trials in the left superior medial frontal gyrus, right anterior cingulate cortex, right superior/middle frontal gyrus, left inferior parietal lobule, left precentral gyrus, and left precuneus and cuneus. Further, the bilateral middle temporal gyrus, bilateral inferior temporal gyrus, and right superior parietal lobule were significantly hypoactive during No-Go trials. Activation of the left superior medial frontal gyrus was positively associated with BIS-11 and Chen Internet Addiction Scale (CIAS) total score across IGA participants. Our data suggest that the prefrontal cortex may be involved in the circuit modulating impulsivity, while its impaired function may relate to high impulsivity in adolescents with IGA, which may contribute directly to the Internet addiction process.

Working Memory Capacity in a Go/No-Go Task: Age Differences in Interference, Processing Speed, and Attentional Control

Science.gov (United States)

Rodríguez-Villagra, Odir Antonio; Göthe, Katrin; Oberauer, Klaus; Kliegl, Reinhold

2013-01-01

We tested the limits of working-memory capacity (WMC) of young adults, old adults, and children with a memory-updating task. The task consisted of mentally shifting spatial positions within a grid according to arrows, their color signaling either only go (control) or go/no-go conditions. The interference model (IM) of Oberauer and Kliegl (2006)…

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Full Text Available ... Balance Play all Try some of these Go4Life exercises to improve your balance! Balance is important because it can help reduce your risk for falls. 3:01 Play next Play now Go4Life Exercise--Stand on One Foot - Duration: 3 minutes, 1 ...

In Silico Predictions of hERG Channel Blockers in Drug Discovery

DEFF Research Database (Denmark)

Taboureau, Olivier; Sørensen, Flemming Steen

2011-01-01

The risk for cardiotoxic side effects represents a major problem in clinical studies of drug candidates and regulatory agencies have explicitly recommended that all new drug candidates should be tested for blockage of the human Ether-a-go-go Related-Gene (hERG) potassium channel. Indeed, several ...

Electrophysiological indices of response inhibition in a Go/NoGo task predict self-control in a social context.

Directory of Open Access Journals (Sweden)

Kyle Nash

Full Text Available Recent research demonstrates that response inhibition-a core executive function-may subserve self-regulation and self-control. However, it is unclear whether response inhibition also predicts self-control in the multifaceted, high-level phenomena of social decision-making. Here we examined whether electrophysiological indices of response inhibition would predict self-control in a social context. Electroencephalography was recorded as participants completed a widely used Go/NoGo task (the cued Continuous Performance Test. Participants then interacted with a partner in an economic exchange game that requires self-control. Results demonstrated that greater NoGo-Anteriorization and larger NoGo-P300 peak amplitudes-two established electrophysiological indices of response inhibition-both predicted more self-control in this social game. These findings support continued integration of executive function and self-regulation and help extend prior research into social decision-making processes.

Pokemon-No-Go?

DEFF Research Database (Denmark)

Nielsen, Marie Vejrup

2016-01-01

Pokemon Go er et teknologisk fænomen som er et eksempel på hvordan lokale sognekirker håndterer nye udviklinger i samfund og kultur.......Pokemon Go er et teknologisk fænomen som er et eksempel på hvordan lokale sognekirker håndterer nye udviklinger i samfund og kultur....

Going to the Dentist

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... Staying Safe Videos for Educators Search English Español Going to the Dentist KidsHealth / For Kids / Going to ... your teeth at home. Flossing involves using a piece of waxy string called dental floss to get ...

12 CFR 347.106 - Going concerns.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Going concerns. 347.106 Section 347.106 Banks... INTERNATIONAL BANKING § 347.106 Going concerns. Going concerns. If a bank acquires an equity interest in a foreign organization that is a going concern, no more than 5 percent of either the consolidated assets or...

Right Fronto-Subcortical White Matter Microstructure Predicts Cognitive Control Ability on the Go/No-go Task in a Community Sample.

Science.gov (United States)

Hinton, Kendra E; Lahey, Benjamin B; Villalta-Gil, Victoria; Boyd, Brian D; Yvernault, Benjamin C; Werts, Katherine B; Plassard, Andrew J; Applegate, Brooks; Woodward, Neil D; Landman, Bennett A; Zald, David H

2018-01-01

Go/no-go tasks are widely used to index cognitive control. This construct has been linked to white matter microstructure in a circuit connecting the right inferior frontal gyrus (IFG), subthalamic nucleus (STN), and pre-supplementary motor area. However, the specificity of this association has not been tested. A general factor of white matter has been identified that is related to processing speed. Given the strong processing speed component in successful performance on the go/no-go task, this general factor could contribute to task performance, but the general factor has often not been accounted for in past studies of cognitive control. Further, studies on cognitive control have generally employed small unrepresentative case-control designs. The present study examined the relationship between go/no-go performance and white matter microstructure in a large community sample of 378 subjects that included participants with a range of both clinical and subclinical nonpsychotic psychopathology. We found that white matter microstructure properties in the right IFG-STN tract significantly predicted task performance, and remained significant after controlling for dimensional psychopathology. The general factor of white matter only reached statistical significance when controlling for dimensional psychopathology. Although the IFG-STN and general factor tracts were highly correlated, when both were included in the model, only the IFG-STN remained a significant predictor of performance. Overall, these findings suggest that while a general factor of white matter can be identified in a young community sample, white matter microstructure properties in the right IFG-STN tract show a specific relationship to cognitive control. The findings highlight the importance of examining both specific and general correlates of cognition, especially in tasks with a speeded component.

Brands and Inhibition: A Go/No-Go Task Reveals the Power of Brand Influence.

Science.gov (United States)

Peatfield, Nicholas; Caulfield, Joanne; Parkinson, John; Intriligator, James

2015-01-01

Whether selecting a candy in a shop or picking a digital camera online, there are usually many options from which consumers may choose. With such abundance, consumers must use a variety of cognitive, emotional, and heuristic means to filter out and inhibit some of their responses. Here we use brand logos within a Go/No-Go task to probe inhibitory control during the presentation of familiar and unfamiliar logos. The results showed no differences in response times or in commission errors (CE) between familiar and unfamiliar logos. However, participants demonstrated a generally more cautious attitude of responding to the familiar brands: they were significantly slower and less accurate at responding to these brands in the Go trials. These findings suggest that inhibitory control can be exercised quite effectively for familiar brands, but that when such inhibition fails, the potent appetitive nature of brands is revealed.

Enhanced conflict monitoring via a short-duration, video-assisted deep breathing in healthy young adults: an event-related potential approach through the Go/NoGo paradigm

Directory of Open Access Journals (Sweden)

Kok Suen Cheng

2017-10-01

Full Text Available Objectives Practitioners of mindfulness are reported to have greater cognitive control especially in conflict monitoring, response inhibition and sustained attention. However, due to the various existing methods in each mindfulness practices and also, the high commitment factor, a barrier still exists for an individual to pick up the practices. Therefore, the effect of short duration deep breathing on the cognitive control is investigated here. Methods Short duration guided deep breathing videos consisting of 5, 7 and 9 min respectively were created and used on subjects training. The effect on cognitive control was assessed using a Go/NoGo task along with event-related potential (ERP measurements at Fz, Cz, and Pz. Results From the study, the significant outcome showed at the follow-up session in which participants engaged for 5 min deep breathing group showed a profound NoGo N2 amplitude increment as compared to the control group, indicating an enhanced conflict monitoring ability. An inverse relationship between the NoGo N2 amplitude and the breathing duration is observed as well at the follow-up session. Conclusion These results indicated the possibility of performing short duration deep breathing guided by a video to achieve an enhanced conflict monitoring as an alternative to other mindfulness practices and 5 min is found to be the optimum practice duration. Significant This study is the first to establish a relationship between deep breathing and conflict monitoring through ERP. The study population of young adults taken from the same environment reduces the variance in ERP results due to age and environment. Limitation A larger sample size would provide a greater statistical power. A longer duration of deep breathing should be investigated to further clarify the relationship between the practice duration and the NoGo N2 amplitude. The result can be split by gender and analyzed separately due to the different brain structure of males

Videogame-Related Illness and Injury: A Review of the Literature and Predictions for Pokémon GO!

Science.gov (United States)

Pourmand, Ali; Lombardi, Kevin; Kuhl, Evan; O'Connell, Francis

2017-02-01

Reports of videogame-related illness and injury soon emerged in the literature with the inception of videogame systems and subsequent development of novel gaming platforms and technologies. In an effort to better detail the impacts of these phenomena and provide recommendations for injury prevention as it relates to Pokémon Go and the larger world of augmented reality games, we conducted an extensive systems-based review of past trends in videogame-related illness and injury from the literature. A literature review using PubMed, Medline, and PsycInfo databases with search terms "Pokémon GO," "videogame injuries," "augmented reality injuries," and "Nintendo Injury" was performed. The search was limited to the English language, and the Boolean were used to combine the search terms. The literature search yielded 359 peer-reviewed articles, 44 of which met the study criteria and included in the review. Seventeen additional popular press reports detailing injuries related to Pokémon Go were also incorporated. Videogame-related injuries and illness include both physical trauma as well as psychological and behavioral disorder with unique patterns of injury and illness linked to specific gaming platforms. As videogames become increasingly advanced and immersive, they expose players to unique and often more serious injury and illness. Augmented reality games, such as Pokémon GO, are the next step in the evolution of this trend and likely portend a future in which many pathologic processes may become increasingly common.

Reinforcement of poly ether sulphones (PES) with exfoliated graphene oxide for aerospace applications

International Nuclear Information System (INIS)

Balasubramanian, K

2012-01-01

Composite materials have been used for aerospace for some time now and have gained virtually 100% acceptance as the materials of choice. Speciality polymers like poly ether sulphones (PES), poly ether ether ketones(PEEK), poly ether imides (PEI) are highly preferred materials as plastic matrix due to their superior temperature performance, excellent wear and friction resistance, excellent dimensional accuracy, high tensile strength, high modulus, precise machinability and chemical resistance. In recent years nanoadditives like single and multiwall carbon nanotubes, graphenes and graphene oxides(GO) are finding huge market potential in aerospace and automobile industries. But manufacture related factors such as particle/ matrix interphases, surface activation, mixing process, particle agglomeration, particle size and shape may lead to different property effects. In this research GO/PES composites were prepared by high shear melt blending technique. GO monolayers were exfoliated from natural graphite flake and dispersed homogeneously in PES matrix for the GO content ranging between 0.5 to 2.0 volume percentage with a high shear twin screw batch mixer. These melt blended nanocomposites were injection moulded for mechanical property validation of tensile strength, flexural modulus and impact resistance. Addition of 0.5 volume percentage of GO enhanced the tensile strength and flexural modulus by 40% and 90% respectively. The results show that addition of GO to PES increase mechanical properties due to the formation of continuous network, good dispersion and strong interfacial interactions. The strong interfacial interactions were accounted for the increase in glass transition temperature. Also there was a significant improvement in the impact resistance of the PES/ GO nanocomposite. The injection moulded samples were tested for stealth performance by measuring the electromagnetic shielding property.

Production, purification, and characterization of micrococcin GO5, a bacteriocin produced by Micrococcus sp. GO5 isolated from kimchi.

Science.gov (United States)

Kim, Mi-Hee; Kong, Yoon-Jung; Baek, Hong; Hyun, Hyung-Hwan

2005-01-01

Strain GO5, a bacteriocin-producing bacterium, was isolated from green onion kimchi and identified as Micrococcus sp. The bacteriocin, micrococcin GO5, displayed a broad spectrum of inhibitory activity against a variety of pathogenic and nonpathogenic microorganisms, as tested by the spot-on-lawn method; its activity spectrum was almost identical to that of nisin. Micrococcin GO5 was inactivated by trypsin (whereas nisin was not) and was completely stable at 100 degrees C for 30 min and in the pH range of 2.0 to 7.0. Micrococcin GO5 exhibited a typical mode of bactericidal activity against Micrococcus flavus ATCC 10240. It was purified to homogeneity through ammonium sulfate precipitation, ultrafiltration, and CM-Sepharose column chromatography. The molecular mass of micrococcin GO5 was estimated to be about 5.0 kDa by tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis and in situ activity assay with the indicator organism. The amino acid sequence of micrococcin GO5 lacks lanthionine and beta-methyllanthionine and is rich in hydrophobic amino acids and glycine, providing the basis for the high heat stability of this bacteriocin. The N-terminal amino acid sequence of micrococcin GO5 is Lys-Lys-Ser-Phe-Cys-Gln-Lys, and no homology to bacteriocins reported previously was observed in the amino acid composition or N-terminal amino acid sequence. Based on the physicochemical properties, small molecular size, and inhibition of Listeria monocytogenes, micrococcin GO5 has been placed with the class II bacteriocins, but its broad spectrum of activity differs from that of other bacteriocins in this class.

Stress among School-Going Adolescents in Relation to Psychological Hardiness

Science.gov (United States)

Singh, Raminder

2016-01-01

The present study was designed to investigate the stress among school-going adolescents in relation to psychological hardiness and also to study the gender and locale-wise differences in various dimensions and components of stress. The study was conducted over a sample of 200 (100 rural and 100 urban) adolescents studying in 10+1 and 10+2 classes…

The human ether-a-go-go-related gene (hERG) current inhibition selectively prolongs action potential of midmyocardial cells to augment transmural dispersion.

Science.gov (United States)

Yasuda, C; Yasuda, S; Yamashita, H; Okada, J; Hisada, T; Sugiura, S

2015-08-01

The majority of drug induced arrhythmias are related to the prolongation of action potential duration following inhibition of rapidly activating delayed rectifier potassium current (I(Kr)) mediated by the hERG channel. However, for arrhythmias to develop and be sustained, not only the prolongation of action potential duration but also its transmural dispersion are required. Herein, we evaluated the effect of hERG inhibition on transmural dispersion of action potential duration using the action potential clamp technique that combined an in silico myocyte model with the actual I(Kr) measurement. Whole cell I(Kr) current was measured in Chinese hamster ovary cells stably expressing the hERG channel. The measured current was coupled with models of ventricular endocardial, M-, and epicardial cells to calculate the action potentials. Action potentials were evaluated under control condition and in the presence of 1, 10, or 100 μM disopyramide, an hERG inhibitor. Disopyramide dose-dependently increased the action potential durations of the three cell types. However, action potential duration of M-cells increased disproportionately at higher doses, and was significantly different from that of epicardial and endocardial cells (dispersion of repolarization). By contrast, the effects of disopyramide on peak I(Kr) and instantaneous current-voltage relation were similar in all cell types. Simulation study suggested that the reduced repolarization reserve of M-cell with smaller amount of slowly activating delayed rectifier potassium current levels off at longer action potential duration to make such differences. The action potential clamp technique is useful for studying the mechanism of arrhythmogenesis by hERG inhibition through the transmural dispersion of repolarization.

Going to the Audiologist

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... Staying Safe Videos for Educators Search English Español Going to the Audiologist KidsHealth / For Kids / Going to ... of lines on the equipment screen or on piece of paper that prints out. Ask the audiologist ...

High-rate supercapacitive performance of GO/r-GO electrodes interfaced with plastic-crystal-based flexible gel polymer electrolyte

International Nuclear Information System (INIS)

Suleman, Mohd; Kumar, Yogesh; Hashmi, S.A.

2015-01-01

We report the performance of symmetrical electric double layer capacitors (EDLCs) fabricated with graphene oxide (GO) and reduced graphene oxide (r-GO) electrodes, and plastic crystal based flexible gel polymer electrolyte (GPE) film. The GPE, comprising the solution of lithium bis(trifluoromethanesulfonyl) imide (LiTFSI) in a plastic crystal succinonitrile (SN) entrapped in poly (vinylidinefluoride-co-hexafluoropropylene) (PVdF-HFP), shows suitability as separator/electrolyte in EDLCs due to its excellent electrochemical properties including high ionic conductivity (∼1.97 × 10 −3 S cm −1 a 20 °C). The GO and r-GO electrodes exhibit supercapacitive properties with the SN-based GPE as evidenced from electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and galvanostatic charge-discharge analyses. The residual oxygen functionalities associated with GO-electrodes provide additional pseudo-capacitance resulting in higher specific capacitance and specific energy (∼66 F g −1 and 18 Wh kg −1 , respectively) as compared to r-GO electrodes (specific capacitance ∼60 F g −1 and specific energy ∼15.6 Wh kg −1 ). High knee frequency f k (∼38 Hz), low response time ∼τ 0 (∼166.5 ms) and high pulse power P 0 (∼32.9 kW kg −1 ), observed from EIS studies, indicate the high rate capability of GO-electrodes-based EDLCs. About three fold increase in f k and three times decrease in τ 0 indicates a substantially higher rate performance of r-GO-based EDLCs with respect to GO-based cell. The high rate capability of GO/r-GO electrodes in combination with SN-based GPEs is further confirmed from the rectangular CV shapes up to scan rates of 5 V s −1 for GO and 10 V s −1 for r-GO electrodes. The r-GO based EDLC offers higher specific power (∼54.9 kW kg −1 ) as compared to that of GO-based EDLC (∼33.3 kW kg −1 ), as observed from charge-discaharge studies. Both EDLCs show stable capacitive performance up to ∼11000-13500 charge

annot8r: GO, EC and KEGG annotation of EST datasets

Directory of Open Access Journals (Sweden)

Schmid Ralf

2008-04-01

Full Text Available Abstract Background The expressed sequence tag (EST methodology is an attractive option for the generation of sequence data for species for which no completely sequenced genome is available. The annotation and comparative analysis of such datasets poses a formidable challenge for research groups that do not have the bioinformatics infrastructure of major genome sequencing centres. Therefore, there is a need for user-friendly tools to facilitate the annotation of non-model species EST datasets with well-defined ontologies that enable meaningful cross-species comparisons. To address this, we have developed annot8r, a platform for the rapid annotation of EST datasets with GO-terms, EC-numbers and KEGG-pathways. Results annot8r automatically downloads all files relevant for the annotation process and generates a reference database that stores UniProt entries, their associated Gene Ontology (GO, Enzyme Commission (EC and Kyoto Encyclopaedia of Genes and Genomes (KEGG annotation and additional relevant data. For each of GO, EC and KEGG, annot8r extracts a specific sequence subset from the UniProt dataset based on the information stored in the reference database. These three subsets are then formatted for BLAST searches. The user provides the protein or nucleotide sequences to be annotated and annot8r runs BLAST searches against these three subsets. The BLAST results are parsed and the corresponding annotations retrieved from the reference database. The annotations are saved both as flat files and also in a relational postgreSQL results database to facilitate more advanced searches within the results. annot8r is integrated with the PartiGene suite of EST analysis tools. Conclusion annot8r is a tool that assigns GO, EC and KEGG annotations for data sets resulting from EST sequencing projects both rapidly and efficiently. The benefits of an underlying relational database, flexibility and the ease of use of the program make it ideally suited for non

Simple synthesis of graphene nanocomposites MgO-rGO and Fe2O3-rGO for multifunctional applications

Science.gov (United States)

Abdel-Aal, Seham K.; Ionov, Andrey; Mozhchil, R. N.; Naqvi, Alim H.

2018-05-01

Hummer's method was used to prepare graphene oxide (GO) by chemical exfoliation of graphite. Simple precipitation method was used for the preparation of hybrid nanocomposites MgO-rGO and Fe2O3-rGO. A 0.3 Molar of corresponding metal nitrate solution and GO solution are used for the preparation process. XRD, FT-IR, and XPS were used to characterize the prepared nanocomposites. The reduction of GO into reduced rGO in the formed nanocomposites was confirmed. Morphological characterization showed the formation of needle-shaped nanocrystals of MgO successfully grown on graphene nanosheet with average crystallite size 8.4 nm. Hematite nanocomposite Fe2O3-rGO forms rod-shaped crystals with average crystallite size 27.5 nm. The saturation magnetization observed for Fe2O3-rGO is less than reported value for the pure Fe2O3 nanoparticles. Thermal properties of as-prepared hybrid nanocomposites MgO-rGO and Fe2O3-rGO showed thermal stability of the prepared nanocomposite over long range of temperature.

Ti-GO-Ag nanocomposite: the effect of content level on the antimicrobial activity and cytotoxicity.

Science.gov (United States)

Jin, Jianfeng; Zhang, Li; Shi, Mengqi; Zhang, Yumei; Wang, Qintao

2017-01-01

Surface modification of titanium (Ti) implants are extensively studied in order to obtain prominent biocompatibility and antimicrobial activity, especially preventing implant-associated infection. In this study, Ti substrates surface were modified by graphene oxide (GO) thin film and silver (Ag) nanoparticles via electroplating and ultraviolet reduction methods so as to achieve this purpose. Microstructures, distribution, quantities and spectral peaks of GO and Ag loading on the Ti sheets surface were characterized. GO-Ag-Ti multiphase nanocomposite exhibited excellent antimicrobial ability and anti-adherence performance. Subsequently, morphology, membrane integrity, apoptosis and relative genes expression of bacteria incubated on the Ti samples surface were monitored to reveal the bactericidal mechanism. Additionally, the cytotoxicity of Ti substrates incorporating GO thin film and Ag nanoparticles were investigated. GO-Ag-Ti composite configuration that have outstanding antibacterial properties will provide the foundation to study bone integration in vitro and in vivo in the future.

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks.

Science.gov (United States)

Eagle, Dawn M; Bari, Andrea; Robbins, Trevor W

2008-08-01

The term 'action inhibition' encapsulates the ability to prevent any form of planned physical response. Growing evidence suggests that different 'stages' or even subtypes of action inhibition activate subtly different neuropharmacological and neuroanatomical processes. In this review, we present evidence from two commonly used and apparently similar behavioural tests, the stop-signal task and the go/no-go task, to determine if these have similar neuroanatomical and neurochemical modulation. Whilst performance of the stop-signal and go/no-go tasks is modulated across only subtly different anatomical networks, serotonin (5-HT) is strongly implicated in inhibitory control on the go/no-go but not the stop-signal task, whereas the stop-signal reaction time appears more sensitive to the action of noradrenaline. There is clear neuropharmacological and neuroanatomical evidence that stop-signal and go/no-go tasks represent different forms of action inhibition. This evidence translates with remarkable consistency across species. We discuss the possible implications of this evidence with respect to the development of novel therapeutic treatments for disorders in which inhibitory deficits are prominent and debilitating.

Reduced dual-task gait speed is associated with visual Go/No-Go brain network activation in children and adolescents with concussion.

Science.gov (United States)

Howell, David R; Meehan, William P; Barber Foss, Kim D; Reches, Amit; Weiss, Michal; Myer, Gregory D

2018-05-31

To investigate the association between dual-task gait performance and brain network activation (BNA) using an electroencephalography (EEG)-based Go/No-Go paradigm among children and adolescents with concussion. Participants with a concussion completed a visual Go/No-Go task with collection of electroencephalogram brain activity. Data were treated with BNA analysis, which involves an algorithmic approach to EEG-ERP activation quantification. Participants also completed a dual-task gait assessment. The relationship between dual-task gait speed and BNA was assessed using multiple linear regression models. Participants (n = 20, 13.9 ± 2.3 years of age, 50% female) were tested at a mean of 7.0 ± 2.5 days post-concussion and were symptomatic at the time of testing (post-concussion symptom scale = 40.4 ± 21.9). Slower dual-task average gait speed (mean = 82.2 ± 21.0 cm/s) was significantly associated with lower relative time BNA scores (mean = 39.6 ± 25.8) during the No-Go task (β = 0.599, 95% CI = 0.214, 0.985, p = 0.005, R 2  = 0.405), while controlling for the effect of age and gender. Among children and adolescents with a concussion, slower dual-task gait speed was independently associated with lower BNA relative time scores during a visual Go/No-Go task. The relationship between abnormal gait behaviour and brain activation deficits may be reflective of disruption to multiple functional abilities after concussion.

Interestingness measures and strategies for mining multi-ontology multi-level association rules from gene ontology annotations for the discovery of new GO relationships.

Science.gov (United States)

Manda, Prashanti; McCarthy, Fiona; Bridges, Susan M

2013-10-01

The Gene Ontology (GO), a set of three sub-ontologies, is one of the most popular bio-ontologies used for describing gene product characteristics. GO annotation data containing terms from multiple sub-ontologies and at different levels in the ontologies is an important source of implicit relationships between terms from the three sub-ontologies. Data mining techniques such as association rule mining that are tailored to mine from multiple ontologies at multiple levels of abstraction are required for effective knowledge discovery from GO annotation data. We present a data mining approach, Multi-ontology data mining at All Levels (MOAL) that uses the structure and relationships of the GO to mine multi-ontology multi-level association rules. We introduce two interestingness measures: Multi-ontology Support (MOSupport) and Multi-ontology Confidence (MOConfidence) customized to evaluate multi-ontology multi-level association rules. We also describe a variety of post-processing strategies for pruning uninteresting rules. We use publicly available GO annotation data to demonstrate our methods with respect to two applications (1) the discovery of co-annotation suggestions and (2) the discovery of new cross-ontology relationships. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

PK/PD Modelling of the QT Interval: a Step Towards Defining the Translational Relationship Between In Vitro, Awake Beagle Dogs, and Humans.

Science.gov (United States)

Marostica, Eleonora; Van Ammel, Karel; Teisman, Ard; Gallacher, David; Van Bocxlaer, Jan; De Ridder, Filip; Boussery, Koen; Vermeulen, An

2016-07-01

Inhibiting the human ether-a-go-go-related gene (hERG)-encoded potassium ion channel is positively correlated with QT-interval prolongation in vivo, which is considered a risk factor for the occurrence of Torsades de Pointes (TdP). A pharmacokinetic/pharmacodynamic model was developed for four compounds that reached the clinic, to relate drug-induced QT-interval change in awake dogs and humans and to derive a translational scaling factor a 1. Overall, dogs were more sensitive than humans to QT-interval change, an a 1 of 1.5 was found, and a 10% current inhibition in vitro produced a higher percent QT-interval change in dogs as compared to humans. The QT-interval changes in dogs were predictive for humans. In vitro and in vivo information could reliably describe the effects in humans. Robust translational knowledge is likely to reduce the need for expensive thorough QT studies; therefore, expanding this work to more compounds is recommended.

The Size of the Universe and Where Will We Go?

Science.gov (United States)

Lawson, B. Mike

2012-01-01

As an avid engineer and amateur astronomer, Mike Lawson presented a perspective on the size of the universe and asked the question, "Where will we go?" This was an entry-level overview for the average space worker who really wanted to understand the size of stars and the distance between objects in space. Mike provided information about familiar orbital objects and elaborated more on galaxies during the discussion. He also explored where humans could go in space and the physical limitations of going there.

Solution-Processed rGO/AgNPs/rGO Sandwich Structure as a Hole Extraction Layer for Polymer Solar Cells

Directory of Open Access Journals (Sweden)

Quang Trung Tran

2015-01-01

Full Text Available We found that inserting silver nanoparticles (AgNPs between two layers of reduced grapheme oxide (rGO has an effect on tailoring the work function of rGO. The utilization of rGO/AgNPs/rGO sandwich structure as the hole extraction layer in polymer solar cells is demonstrated. Solution-processable fabrication of this sandwich structure at the ITO/active layer interface facilitates the extraction of hole from active layer into ITO anode because of lowering the barrier level alignment at the interface. It results in an improvement of the short circuit current density and the overall photovoltaic performance.

Go-flow: a reliability analysis methodology applicable to piping system

International Nuclear Information System (INIS)

Matsuoka, T.; Kobayashi, M.

1985-01-01

Since the completion of the Reactor Safety Study, the use of probabilistic risk assessment technique has been becoming more widespread in the nuclear community. Several analytical methods are used for the reliability analysis of nuclear power plants. The GO methodology is one of these methods. Using the GO methodology, the authors performed a reliability analysis of the emergency decay heat removal system of the nuclear ship Mutsu, in order to examine its applicability to piping systems. By this analysis, the authors have found out some disadvantages of the GO methodology. In the GO methodology, the signal is on-to-off or off-to-on signal, therefore the GO finds out the time point at which the state of a system changes, and can not treat a system which state changes as off-on-off. Several computer runs are required to obtain the time dependent failure probability of a system. In order to overcome these disadvantages, the authors propose a new analytical methodology: GO-FLOW. In GO-FLOW, the modeling method (chart) and the calculation procedure are similar to those in the GO methodology, but the meaning of signal and time point, and the definitions of operators are essentially different. In the paper, the GO-FLOW methodology is explained and two examples of the analysis by GO-FLOW are given

NegGOA: negative GO annotations selection using ontology structure.

Science.gov (United States)

Fu, Guangyuan; Wang, Jun; Yang, Bo; Yu, Guoxian

2016-10-01

Predicting the biological functions of proteins is one of the key challenges in the post-genomic era. Computational models have demonstrated the utility of applying machine learning methods to predict protein function. Most prediction methods explicitly require a set of negative examples-proteins that are known not carrying out a particular function. However, Gene Ontology (GO) almost always only provides the knowledge that proteins carry out a particular function, and functional annotations of proteins are incomplete. GO structurally organizes more than tens of thousands GO terms and a protein is annotated with several (or dozens) of these terms. For these reasons, the negative examples of a protein can greatly help distinguishing true positive examples of the protein from such a large candidate GO space. In this paper, we present a novel approach (called NegGOA) to select negative examples. Specifically, NegGOA takes advantage of the ontology structure, available annotations and potentiality of additional annotations of a protein to choose negative examples of the protein. We compare NegGOA with other negative examples selection algorithms and find that NegGOA produces much fewer false negatives than them. We incorporate the selected negative examples into an efficient function prediction model to predict the functions of proteins in Yeast, Human, Mouse and Fly. NegGOA also demonstrates improved accuracy than these comparing algorithms across various evaluation metrics. In addition, NegGOA is less suffered from incomplete annotations of proteins than these comparing methods. The Matlab and R codes are available at https://sites.google.com/site/guoxian85/neggoa gxyu@swu.edu.cn Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Synthesis and characterization of GO-hydrogels composites

Science.gov (United States)

Pereyra, J. Y.; Cuello, E. A.; Coneo Rodriguez, R.; Barbero, C. A.; Yslas, E. I.; Salavagione, H. J.; Acevedo, D. F.

2017-10-01

The preparation of poly(N-isopropylacrylamide) (PNIPAm) hydrogel nanocomposites containing graphene oxide (GO) and GO plus carbon nanotubes (CNT) in the polymer network is communicated. This one-pot preparation methods include the dispersion of GO (or GO plus CNT) in a solution of monomers and the subsequent polymerization. The texture of the nanocomposites was studied using scanning electron microscopy (SEM), where very compact surfaces are observed suggesting good dispersion of GO sheets and CNTs within the polymer matrix. The presence of GO inside the polymer network diminished the equilibrium swelling values and increased the elastic modulus up to 162 % with respect to the pure gel. Similar results were observed for the composite with CNT. Furthermore, the electrical resistivity of PNIPAm-GO diminishes as the applied compression force increases, being 50 % lower than hydrogel without GO. Moreover, the electrochemical properties of the hydrogels, evaluated by cyclic voltammetry, indicate highly reversible electrical charge/discharge response. In order to apply these materials for antibiotic delivery, the absorption of tetracycline (tet) is evaluated and the nanocomposites showed better absorption capability and improved antibiotic delivery. Preliminary results suggest that tet loaded PNIPAm-GO and PNIPAM-GO-CNT display antimicrobial activity against the Pseudomonas aeruginosa turning these materials as potential candidates for biomedical applications.

Spectrum analysis of the reduction degree of two-step reduced graphene oxide (GO) and the polymer/r-GO composites

Energy Technology Data Exchange (ETDEWEB)

She, Xilin, E-mail: xlshe@qdu.edu.cn [College of Chemical and Environmental Engineering, Qingdao University, Qingdao 266071 (China); Liu, Tongchao; Wu, Nan [College of Chemical and Environmental Engineering, Qingdao University, Qingdao 266071 (China); Xu, Xijin [School of Physics and Technology, University of Jinan, Jinan 250022 (China); Li, Jianjiang [College of Chemical and Environmental Engineering, Qingdao University, Qingdao 266071 (China); Yang, Dongjiang, E-mail: d.yang@qdu.edu.cn [College of Chemical and Environmental Engineering, Qingdao University, Qingdao 266071 (China); School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001 (Australia); Frost, Ray [School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001 (Australia)

2013-12-16

In this paper, the reduction degree of graphene oxide (GO) reduced using chemical reduction and thermal reduction methods was characterized by spectrum analysis. The optimized conditions of reducing GO were determined that the hydrazine hydrate is the best reducing agent and the appropriate thermal reduction temperature is at 240 °C. The obtained GO solution was mixed with polystyrene (PS) solution to prepare PS/r-GO composites by using two-step reduction technique under the optimized conditions. The structure and micro-morphology of GO, r-GO and PS/r-GO composites were characterized by Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM) respectively. It is also observed that the two-step reduction pathway is more effective than one-step reduction for improving the reduction degree of GO. Accordingly, the electric conductivity of PS/r-GO composites prepared by two-step reduction technique is as high as 21.45 S m{sup −1}, which is much higher than that of composites fabricated by one-step reduction method. The spectrum techniques will highlight new opportunities for investigating the reduction degree of GO in polymer composites. - Highlights: • Spectrum analysis on the reduction degree of GO reduced by different methods. • Determine the optimized reduction conditions of GO and polymer/r-GO composites. • The two-step reduction is more effective than one-step reduction.

Spectrum analysis of the reduction degree of two-step reduced graphene oxide (GO) and the polymer/r-GO composites

International Nuclear Information System (INIS)

She, Xilin; Liu, Tongchao; Wu, Nan; Xu, Xijin; Li, Jianjiang; Yang, Dongjiang; Frost, Ray

2013-01-01

In this paper, the reduction degree of graphene oxide (GO) reduced using chemical reduction and thermal reduction methods was characterized by spectrum analysis. The optimized conditions of reducing GO were determined that the hydrazine hydrate is the best reducing agent and the appropriate thermal reduction temperature is at 240 °C. The obtained GO solution was mixed with polystyrene (PS) solution to prepare PS/r-GO composites by using two-step reduction technique under the optimized conditions. The structure and micro-morphology of GO, r-GO and PS/r-GO composites were characterized by Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM) respectively. It is also observed that the two-step reduction pathway is more effective than one-step reduction for improving the reduction degree of GO. Accordingly, the electric conductivity of PS/r-GO composites prepared by two-step reduction technique is as high as 21.45 S m −1 , which is much higher than that of composites fabricated by one-step reduction method. The spectrum techniques will highlight new opportunities for investigating the reduction degree of GO in polymer composites. - Highlights: • Spectrum analysis on the reduction degree of GO reduced by different methods. • Determine the optimized reduction conditions of GO and polymer/r-GO composites. • The two-step reduction is more effective than one-step reduction

Tinjauan Desain Website Kemlu.Go.Id

OpenAIRE

Danu Widhyatmoko

2013-01-01

Review of kemlu.go.id website design is a research report on Kemlu.go.id website design. Kemlu.go.id website aims to be the information gateway of Ministry of Foreign Affairs, and also as guidelines of foreign politic policies of Republic of Indonesia. The review had been accomplished by using analytical method based on the "Nine Essential Principles for Good Web Design" developed by Collis Ta'eed (2007). At the end of the article, several recommendations in developing kemlu.go.id website are...

"To Boldly Go" versus "Last, Best Hope" : The Future of Human Civilization as Depicted in American Science Fiction

OpenAIRE

Glasø, Alexander

2012-01-01

"'To Boldly Go" versus "Last, Best Hope'" examines a total of four American television series from the Star Trek and Babylon 5 franchises, and the portrayal of human civilization in the future. The thesis traces how Star Trek set out "to boldly go" and how Babylon 5 was the "last, best hope" in depicting a coherent, futuristic vision for humanity. The initial chapter focuses on the background of the series and also the ways they differed from one another, while chapter 2 is devoted to the por...

An In Vitro Study of the Photodynamic Effectiveness of GO-Ag Nanocomposites against Human Breast Cancer Cells

Directory of Open Access Journals (Sweden)

Fozia Shaheen

2017-11-01

Full Text Available Graphene-based materials have garnered significant attention because of their versatile bioapplications and extraordinary properties. Graphene oxide (GO is an extremely oxidized form of graphene accompanied by the functional groups of oxygen on its surface. GO is an outstanding platform on which to pacify silver nanoparticles (Ag NPs, which gives rise to the graphene oxide-silver nanoparticle (GO-Ag nanocomposite. In this experimental study, the toxicity of graphene oxide-silver (GO-Ag nanocomposites was assessed in an in vitro human breast cancer model to optimize the parameters of photodynamic therapy. GO-Ag was prepared using the hydrothermal method, and characterization was done by X-ray diffraction, field-emission scanning electron microscope (FE-SEM, transmission Electron Microscopy (TEM, energy dispersive X-rays Analysis (EDAX, atomic force microscopy and ultraviolet-visible spectroscopy. The experiments were done both with laser exposure, as well as in darkness, to examine the phototoxicity and cytotoxicity of the nanocomposites. The cytotoxicity of the GO-Ag was confirmed via a methyl-thiazole-tetrazolium (MTT assay and intracellular reactive oxygen species production analysis. The phototoxic effect explored the dose-dependent decrease in the cell viability, as well as provoked cell death via apoptosis. An enormously significant escalation of 1O2 in the samples when exposed to daylight was perceived. Statistical analysis was performed on the experimental results to confirm the worth and clarity of the results, with p-values < 0.05 selected as significant. These outcomes suggest that GO-Ag nanocomposites could serve as potential candidates for targeted breast cancer therapy.

Tinjauan Desain Website Kemlu.Go.Id

Directory of Open Access Journals (Sweden)

Danu Widhyatmoko

2013-04-01

Full Text Available Review of kemlu.go.id website design is a research report on Kemlu.go.id website design. Kemlu.go.id website aims to be the information gateway of Ministry of Foreign Affairs, and also as guidelines of foreign politic policies of Republic of Indonesia. The review had been accomplished by using analytical method based on the "Nine Essential Principles for Good Web Design" developed by Collis Ta'eed (2007. At the end of the article, several recommendations in developing kemlu.go.id website are presented to create better appearance.  

Event Management Application in Go-food Culinary Festival with 50 Best Merchants and Road to Go-food Culinary Festival as a Tenant Manager and Sponsorship

OpenAIRE

Syahida Istiqamah, Nazhara; Setyabudi, Djoko

2017-01-01

GO-FOOD, a service featured by go-jek to provide food delivery service. More than 500 restaurants have built partnerships with GO-FOOD Semarang. GO-JEK Semarang also wanted to held an event that was provided by GO-FOOD Semarang itself. GO-FOOD Culinary Festival with 50 best merchants, themed Journey to independence day tells us the Indonesian national history to set free from Colonialists. There was also an event named road to GO-FOOD Culinary Festival as the series of its event held on three...

Existence and control of Go/No-Go decision transition threshold in the striatum.

Directory of Open Access Journals (Sweden)

Jyotika Bahuguna

2015-04-01

Full Text Available A typical Go/No-Go decision is suggested to be implemented in the brain via the activation of the direct or indirect pathway in the basal ganglia. Medium spiny neurons (MSNs in the striatum, receiving input from cortex and projecting to the direct and indirect pathways express D1 and D2 type dopamine receptors, respectively. Recently, it has become clear that the two types of MSNs markedly differ in their mutual and recurrent connectivities as well as feedforward inhibition from FSIs. Therefore, to understand striatal function in action selection, it is of key importance to identify the role of the distinct connectivities within and between the two types of MSNs on the balance of their activity. Here, we used both a reduced firing rate model and numerical simulations of a spiking network model of the striatum to analyze the dynamic balance of spiking activities in D1 and D2 MSNs. We show that the asymmetric connectivity of the two types of MSNs renders the striatum into a threshold device, indicating the state of cortical input rates and correlations by the relative activity rates of D1 and D2 MSNs. Next, we describe how this striatal threshold can be effectively modulated by the activity of fast spiking interneurons, by the dopamine level, and by the activity of the GPe via pallidostriatal backprojections. We show that multiple mechanisms exist in the basal ganglia for biasing striatal output in favour of either the `Go' or the `No-Go' pathway. This new understanding of striatal network dynamics provides novel insights into the putative role of the striatum in various behavioral deficits in patients with Parkinson's disease, including increased reaction times, L-Dopa-induced dyskinesia, and deep brain stimulation-induced impulsivity.

Existence and control of Go/No-Go decision transition threshold in the striatum.

Science.gov (United States)

Bahuguna, Jyotika; Aertsen, Ad; Kumar, Arvind

2015-04-01

A typical Go/No-Go decision is suggested to be implemented in the brain via the activation of the direct or indirect pathway in the basal ganglia. Medium spiny neurons (MSNs) in the striatum, receiving input from cortex and projecting to the direct and indirect pathways express D1 and D2 type dopamine receptors, respectively. Recently, it has become clear that the two types of MSNs markedly differ in their mutual and recurrent connectivities as well as feedforward inhibition from FSIs. Therefore, to understand striatal function in action selection, it is of key importance to identify the role of the distinct connectivities within and between the two types of MSNs on the balance of their activity. Here, we used both a reduced firing rate model and numerical simulations of a spiking network model of the striatum to analyze the dynamic balance of spiking activities in D1 and D2 MSNs. We show that the asymmetric connectivity of the two types of MSNs renders the striatum into a threshold device, indicating the state of cortical input rates and correlations by the relative activity rates of D1 and D2 MSNs. Next, we describe how this striatal threshold can be effectively modulated by the activity of fast spiking interneurons, by the dopamine level, and by the activity of the GPe via pallidostriatal backprojections. We show that multiple mechanisms exist in the basal ganglia for biasing striatal output in favour of either the `Go' or the `No-Go' pathway. This new understanding of striatal network dynamics provides novel insights into the putative role of the striatum in various behavioral deficits in patients with Parkinson's disease, including increased reaction times, L-Dopa-induced dyskinesia, and deep brain stimulation-induced impulsivity.

Going Green

Centers for Disease Control (CDC) Podcasts

This podcast is for a general audience and provides information on how to recycle, re-use, and restore. It also covers the benefits of “Going Green" on the environment, health, and social interaction.

WHAT MAKES THINGS GO.

Science.gov (United States)

Mobilization for Youth, Inc., New York, NY.

THE INITIAL QUESTION IN THE TITLE IS ANSWERED THROUGH SIMPLE EXPERIMENTS FOR CULTURALLY DISADVANTAGED CHILDREN IN ELEMENTARY SCHOOL. MUSCLES, RUNNING, WATER, WIND, STEAM, FAST BURNING AND ELECTRICITY ARE FOUND TO "MAKE THINGS GO." USING THESE BASIC DISCOVERIES, VOCABULARY IS BUILT UP BY WORKING WITH DIFFERENT WORDS RELATING TO THE…

GLOBE Goes GO with Mosquitoes

Science.gov (United States)

Boger, R. A.; Low, R.

2016-12-01

The GLOBE Mosquito Larvae protocol and a new citizen science initiative, GLOBE Observers (GO), were both launched in Summer 2016. While the GLOBE Mosquito Larvae Protocol and associated educational materials target K-16 student inquiry and research, the GO protocol version is simplified to enable citizen scientists of all ages from all walks of life to participate. GO allows citizen scientists to collect and submit environmental data through an easy-to-use smart phone app available for both Apple and Android mobile devices. GO mosquito asks for photos of larvae mosquito genus or species, location, and type of water source (e.g., container or pond) where the larvae were found. To initiate the new mosquito GLOBE/GO opportunities, workshops have been held in Barbuda, Thailand, West Indies, US Gulf Coast, New York City, and at the GLOBE Annual Meeting in Colorado. Through these venues, the protocols have been refined and a field campaign has been initiated so that GO and GLOBE citizen scientists (K-16 students and all others) can contribute data. Quality assurance measures are taken through the online training required to participate and the validation of identification by other citizen sciences and mosquito experts. Furthermore, initial research is underway to develop optical recognition software starting with the species that carry the Zika virus (Aedes aegypti and A. albopictus). With this launch, we plan to move forward by providing opportunities throughout the world to engage people in meaningful environmental and public health data collection and to promote citizen scientists to become agents of change in their communities.

Flexible room-temperature formaldehyde sensors based on rGO film and rGo/MoS2 hybrid film.

Science.gov (United States)

Li, Xian; Wang, Jing; Xie, Dan; Xu, Jianlong; Xia, Yi; Li, Weiwei; Xiang, Lan; Li, Zhemin; Xu, Shiwei; Komarneni, Sridhar

2017-08-11

Gas sensors based on reduced graphene oxide (rGO) films and rGO/MoS 2 hybrid films were fabricated on polyethylene naphthalate substrates by a simple self-assembly method, which yielded flexible devices for detection of formaldehyde (HCHO) at room temperature. The sensing test results indicated that the rGO and rGO/MoS 2 sensors were highly sensitive and fully recoverable to a ppm-level of HCHO. The bending and fatigue test results revealed that the sensors were also mechanically robust, durable and effective for long-term use. The rGO/MoS 2 sensors showed higher sensitivities than rGO sensors, which was attributed to the enhanced HCHO adsorption and electron transfer mediated by MoS 2 . Furthermore, two kinds of MoS 2 nanosheets were prepared by either hydrothermal synthesis or chemical exfoliation and were compared for their detection of HCHO, which revealed that the hydrothermally produced MoS 2 nanosheets with rich defects led to enhanced sensitivity of the rGO/MoS 2 sensors. Moreover, these fabricated flexible sensors can be applied for the HCHO detection in food packaging.

To issue or not to issue a going concern opinion : A study of factors and incentives influencing auditors’ ability and decision to issue going concern opinions

OpenAIRE

Nordholm, Elin; Björkstrand, Anette

2014-01-01

If auditors question a company’s ability to continue existing, they should issue a going concern opinion in the audit report. Whether or not auditors will issue a going concern opinion depends on auditors’ ability to identify going concern problems, as well as their decision whether or not to issue going concern opinions. In Sweden, the going concern accuracy rate has been low compared to other countries. The aim of this study is therefore to analyse whether it is auditors’ lack of ability to...

Fabrication of TiO2 nanorod assembly grafted rGO (rGO@TiO2-NR) hybridized flake-like photocatalyst

Science.gov (United States)

Lv, Kangle; Fang, Shun; Si, Lingling; Xia, Yang; Ho, Wingkei; Li, Mei

2017-01-01

To efficiently separate the photo-generated electron-hole pairs of TiO2 hybrid, anatase TiO2 nanorod assembly grafted reduced graphene oxides (rGO@TiO2-NR) hybrid was successfully fabricated using potassium titanium oxalate (PTO) and graphene oxides (GO) as starting materials and diethylene glycol (DEG) as reductant. The effect of GO content on the structure and photocatalytic activity of rGO@TiO2-NR composite was systematically studied. Results show that, in the absence of GO, only TiO2 microsphere assembly is obtained from TiO2 nanorods. The presence of GO results in the formation of a flake-like TiO2-nanorod-assembled grafted rGO hybrid. The photocatalytic activity of rGO@TiO2-NR composite increases first and then decreases with increase in the amount of GO from 0 wt.% to 10 wt.%. The hybridized S4 sample prepared with 4 wt.% GO possesses the highest photocatalytic activity with a constant rate of 0.039 min-1 in the photocataytic degradation of Brilliant X-3B dye (X3B); this sample was enhanced more than three times when compared with pure TiO2 sample (0.012 min-1). The enhanced photocatalytic activity of the rGO@TiO2-NR hybrid was attributed to the strong interaction between TiO2 nanorods and rGO. The unique hierarchical structure of 1D nanorod assembly TiO2-rGO flakes facilitates the injection and transfer of photo-generated electrons from TiO2 to graphene, thus retarding the recombination of electron-hole pairs and enhancing the photocatalytic activity. The enlarged BET surface areas, not only increasing the number of active sites, but also facilitating the adsorption of the dye, and improved light-harvesting ability also contribute to the enhanced photoreactivity of rGO@TiO2-NR hybrid.

Enhanced hydrogen storage in sandwich-structured rGO/Co1-xS/rGO hybrid papers through hydrogen spillover

Science.gov (United States)

Han, Lu; Qin, Wei; Jian, Jiahuang; Liu, Jiawei; Wu, Xiaohong; Gao, Peng; Hultman, Benjamin; Wu, Gang

2017-08-01

Reduced graphene oxide (rGO) based two-dimensional (2D) structures have been fabricated for electrochemical hydrogen storage. However, the effective transfer of atomic hydrogen to adjacent rGO surfaces is suppressed by binders, which are widely used in conventional electrochemical hydrogen storage electrodes, leading to a confining of the performance of rGO for hydrogen storage. As a proof of concept experiment, a novel strategy is developed to fabricate the binder-free sandwich-structured rGO/Co1-xS/rGO hybrid paper via facile ball milling and filtration process. Based on the structure investigation, Co1-xS is immobilized in the space between the individual rGO sheets by the creation of chemical "bridges" (Csbnd S bonds). Through the Csbnd S bonds, the atomic hydrogen is transferred from Co1-xS to rGO accompanying a Csbnd H chemical bond formation. When used as an electrode, the hybrid paper exhibits an improved hydrogen storage capacity of 3.82 wt% and, most importantly, significant cycling stability for up to 50 cycles. Excluding the direct hydrogen storage contribution from the Co1-xS in the hybrid paper, the hydrogen storage ability of rGO is enhanced by 10× through the spillover effects caused by the Co1-xS modifier.

Fabrication of TiO_2 nanorod assembly grafted rGO (rGO@TiO_2-NR) hybridized flake-like photocatalyst

International Nuclear Information System (INIS)

Lv, Kangle; Fang, Shun; Si, Lingling; Xia, Yang; Ho, Wingkei; Li, Mei

2017-01-01

Highlights: • TiO_2 nanorod assembly grafted with GO hybrid was successfully fabricated. • TiO_2 nanorods can reduce the aggregation of TiO_2 nanoparticles on graphene. • This unique structure facilitates the injection of electron from TiO_2 to graphene. - Abstract: To efficiently separate the photo-generated electron–hole pairs of TiO_2 hybrid, anatase TiO_2 nanorod assembly grafted reduced graphene oxides (rGO@TiO_2-NR) hybrid was successfully fabricated using potassium titanium oxalate (PTO) and graphene oxides (GO) as starting materials and diethylene glycol (DEG) as reductant. The effect of GO content on the structure and photocatalytic activity of rGO@TiO_2-NR composite was systematically studied. Results show that, in the absence of GO, only TiO_2 microsphere assembly is obtained from TiO_2 nanorods. The presence of GO results in the formation of a flake-like TiO_2-nanorod-assembled grafted rGO hybrid. The photocatalytic activity of rGO@TiO_2-NR composite increases first and then decreases with increase in the amount of GO from 0 wt.% to 10 wt.%. The hybridized S4 sample prepared with 4 wt.% GO possesses the highest photocatalytic activity with a constant rate of 0.039 min"−"1 in the photocataytic degradation of Brilliant X-3B dye (X3B); this sample was enhanced more than three times when compared with pure TiO_2 sample (0.012 min"−"1). The enhanced photocatalytic activity of the rGO@TiO_2-NR hybrid was attributed to the strong interaction between TiO_2 nanorods and rGO. The unique hierarchical structure of 1D nanorod assembly TiO_2–rGO flakes facilitates the injection and transfer of photo-generated electrons from TiO_2 to graphene, thus retarding the recombination of electron–hole pairs and enhancing the photocatalytic activity. The enlarged BET surface areas, not only increasing the number of active sites, but also facilitating the adsorption of the dye, and improved light-harvesting ability also contribute to the enhanced photoreactivity

Annotating activation/inhibition relationships to protein-protein interactions using gene ontology relations.

Science.gov (United States)

Yim, Soorin; Yu, Hasun; Jang, Dongjin; Lee, Doheon

2018-04-11

Signaling pathways can be reconstructed by identifying 'effect types' (i.e. activation/inhibition) of protein-protein interactions (PPIs). Effect types are composed of 'directions' (i.e. upstream/downstream) and 'signs' (i.e. positive/negative), thereby requiring directions as well as signs of PPIs to predict signaling events from PPI networks. Here, we propose a computational method for systemically annotating effect types to PPIs using relations between functional information of proteins. We used regulates, positively regulates, and negatively regulates relations in Gene Ontology (GO) to predict directions and signs of PPIs. These relations indicate both directions and signs between GO terms so that we can project directions and signs between relevant GO terms to PPIs. Independent test results showed that our method is effective for predicting both directions and signs of PPIs. Moreover, our method outperformed a previous GO-based method that did not consider the relations between GO terms. We annotated effect types to human PPIs and validated several highly confident effect types against literature. The annotated human PPIs are available in Additional file 2 to aid signaling pathway reconstruction and network biology research. We annotated effect types to PPIs by using regulates, positively regulates, and negatively regulates relations in GO. We demonstrated that those relations are effective for predicting not only signs, but also directions of PPIs. The usefulness of those relations suggests their potential applications to other types of interactions such as protein-DNA interactions.

The Portuguese Contribution for lab2go - pt.lab2go

Directory of Open Access Journals (Sweden)

Maria Teresa Restivo

2013-01-01

Full Text Available Online experimentation provides innovative and valuable tools for use in academy, in high schools, in industry and in medical areas. It has also become a precious tool for educational and training purposes in any of those areas. Looking at online experimentation as a pure distance learning tool it represents a very efficient way of sharing hands-on capabilities, for example with developing countries. In Portugal a new consortium of online experimentation was created for fostering the national potential, using the Portuguese version of lab2go web platform, pt.lab2go. The authors pretend to demonstrate some of capabilities of the consortium in sharing online labs.

THE CONSUMER CONCEPT IN G.O. NO. 107/1999 AND G.O. NO. 21/1992. COMPARATIVE APPROACH

Directory of Open Access Journals (Sweden)

Andreea-Teodora STANESCU

2017-07-01

Full Text Available Government Ordinance no. 107/1999 is a normative act with relevance in the field of consumer protection. Thus, according to Article 30, the ordinance is supplemented by GO no. 21/1992 on consumer protection. In this context, it should be noted that the notion of consumer as defined by GO no. 107/1999 is not identical to that used in consumer protection regulations. Thus, contracts for the sale of package travels may be contracts concluded with consumers from the perspective of GO no. 107/1999, but not from the point of view of consumer protection regulations. This study will identify the features of the consumer concept in GO no. 107/1999 and in GO no. 21/1992, as a normative act comprising the common law in the field of consumer protection. By identifying the differences between concepts, this study will exemplify their legal relevance in terms of consumer protection against the introduction of unfair contract terms.

Stats to go

CERN Document Server

Buglear, John

2000-01-01

'Stats to Go' is a user-friendly guide for hospitality, leisure and tourism students who need to learn statistics and statistical techniques. 'Stats to go' is an ideal companion to hospitality, leisure and tourism studies as the breadth of coverage supports all taught numerical aspects of these types of course. Examples from hospitality, leisure and tourism organizations: * licensed premises * fast food outlets * hotels * theme parks and their environments are used to illustrate key issues of the text. The area of quantitative methods is one which many students find unapproachable or daunting. With the use of a clear learning structure, and a user friendly, non-theoretical approach, Buglear has created a text which students and lecturers alike will find indispensable.

Transcriptome and Gene Ontology (GO) Enrichment Analysis Reveals Genes Involved in Biotin Metabolism That Affect L-Lysine Production in Corynebacterium glutamicum.

Science.gov (United States)

Kim, Hong-Il; Kim, Jong-Hyeon; Park, Young-Jin

2016-03-09

Corynebacterium glutamicum is widely used for amino acid production. In the present study, 543 genes showed a significant change in their mRNA expression levels in L-lysine-producing C. glutamicum ATCC21300 than that in the wild-type C. glutamicum ATCC13032. Among these 543 differentially expressed genes (DEGs), 28 genes were up- or downregulated. In addition, 454 DEGs were functionally enriched and categorized based on BLAST sequence homologies and gene ontology (GO) annotations using the Blast2GO software. Interestingly, NCgl0071 (bioB, encoding biotin synthase) was expressed at levels ~20-fold higher in the L-lysine-producing ATCC21300 strain than that in the wild-type ATCC13032 strain. Five other genes involved in biotin metabolism or transport--NCgl2515 (bioA, encoding adenosylmethionine-8-amino-7-oxononanoate aminotransferase), NCgl2516 (bioD, encoding dithiobiotin synthetase), NCgl1883, NCgl1884, and NCgl1885--were also expressed at significantly higher levels in the L-lysine-producing ATCC21300 strain than that in the wild-type ATCC13032 strain, which we determined using both next-generation RNA sequencing and quantitative real-time PCR analysis. When we disrupted the bioB gene in C. glutamicum ATCC21300, L-lysine production decreased by approximately 76%, and the three genes involved in biotin transport (NCgl1883, NCgl1884, and NCgl1885) were significantly downregulated. These results will be helpful to improve our understanding of C. glutamicum for industrial amino acid production.

A novel fabrication of a high performance SiO(2)-graphene oxide (GO) nanohybrids: Characterization of thermal properties of epoxy nanocomposites filled with SiO(2)-GO nanohybrids.

Science.gov (United States)

Haeri, S Z; Ramezanzadeh, B; Asghari, M

2017-05-01

In this study it has been aimed to enhance the thermal resistance of epoxy coating through incorporation of SiO 2 -GO nanohybrids. SiO 2 -GO nanohybrids were synthesized through one-step sol-gel route using a mixture of Tetraethylorthosilane (TEOS) and 3-Aminopropyl triethoxysilane (APTES) silanes. The SiO 2 -GO nanohybrids were prepared at various hydrolysis times of 24, 48 and 72h. Then 0.2wt.% of GO and SiO 2 -GO nanohybrids were separately incorporated into the epoxy coating. Results revealed that amino functionalized SiO 2 nanoparticles with particle size around 20-30nm successfully synthesized on the basal plane of GO. Results showed significant improvement of dispersion and interfacial interactions between nanohybrids and epoxy composite arising from covalent bonding between the SiO 2 -GO and the epoxy matrix. It was found that the thermal resistance of SiO 2 -GO nanohybrids and SiO 2 -GO/Epoxy nanocomposite was noticeably higher than GO and epoxy matrix, respectively. Copyright © 2017 Elsevier Inc. All rights reserved.

Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene and the Regulatory Subunit KCNE2 from Equine Myocardium.

Directory of Open Access Journals (Sweden)

Philip Juul Pedersen

Full Text Available The KCNH2 and KCNE2 genes encode the cardiac voltage-gated K+ channel KV11.1 and its auxiliary β subunit KCNE2. KV11.1 is critical for repolarization of the cardiac action potential. In humans, mutations or drug therapy affecting the KV11.1 channel are associated with prolongation of the QT intervals on the ECG and increased risk of ventricular tachyarrhythmia and sudden cardiac death--conditions known as congenital or acquired Long QT syndrome (LQTS, respectively. In horses, sudden, unexplained deaths are a well-known problem. We sequenced the cDNA of the KCNH2 and KCNE2 genes using RACE and conventional PCR on mRNA purified from equine myocardial tissue. Equine KV11.1 and KCNE2 cDNA had a high homology to human genes (93 and 88%, respectively. Equine and human KV11.1 and KV11.1/KCNE2 were expressed in Xenopus laevis oocytes and investigated by two-electrode voltage-clamp. Equine KV11.1 currents were larger compared to human KV11.1, and the voltage dependence of activation was shifted to more negative values with V1/2 = -14.2±1.1 mV and -17.3±0.7, respectively. The onset of inactivation was slower for equine KV11.1 compared to the human homolog. These differences in kinetics may account for the larger amplitude of the equine current. Furthermore, the equine KV11.1 channel was susceptible to pharmacological block with terfenadine. The physiological importance of KV11.1 was investigated in equine right ventricular wedge preparations. Terfenadine prolonged action potential duration and the effect was most pronounced at slow pacing. In conclusion, these findings indicate that horses could be disposed to both congenital and acquired LQTS.

Mechanical properties of graphene oxide (GO/epoxy composites

Directory of Open Access Journals (Sweden)

Shivan Ismael Abdullah

2015-08-01

Full Text Available In this study, the effects of graphene oxide (GO on composites based on epoxy resin were analyzed. Different contents of GO (1.5–6 vol.% were added to epoxy resin. The GO/epoxy composite was prepared using the casting method and was prepared under room temperature. Mechanical tests’ results such as tensile test, impact test and hardness test show enhancements of the mechanical properties of the GO/epoxy composite. The experimental results clearly show an improvement in the Young’s modulus, tensile strength and hardness. The impact strength was seen to decrease, pointing to brittleness increase of the GO/epoxy composite. A microstructure analysis using Scanning Electron Microscopy (SEM and X-ray diffraction (XRD analysis was also performed, which showed how GO impeded the propagation of cracks in the composite. From the SEM images we observed the interface between the GO and the epoxy composite. As can be seen from this research, the GO/epoxy composites can be used for a large number of applications. The results of this research are a strong evidence for GO/epoxy composites being a potential candidate for use in a variety of industrial applications, especially for automobile parts, aircraft components, and electronic parts such as supercapacitors, transistors, etc.

Response inhibition in borderline personality disorder: event-related potentials in a Go/Nogo task.

Science.gov (United States)

Ruchsow, M; Groen, G; Kiefer, M; Buchheim, A; Walter, H; Martius, P; Reiter, M; Hermle, L; Spitzer, M; Ebert, D; Falkenstein, M

2008-01-01

Borderline personality disorder (BPD) has been related to a dysfunction of anterior cingulate cortex, amygdala, and prefrontal cortex and has been associated clinically with impulsivity, affective instability, and significant interpersonal distress. We examined 17 patients with BPD and 17 age-, sex-, and education matched control participants with no history of Axis I or II psychopathology using event-related potentials (ERPs). Participants performed a hybrid flanker-Go/Nogo task while multichannel EEG was recorded. Our study focused on two ERP components: the Nogo-N2 and the Nogo-P3, which have been discussed in the context of response inhibition and response conflict. ERPs were computed on correct Go trials (button press) and correct Nogo trials (no button press), separately. Groups did not differ with regard to the Nogo-N2. However, BPD patients showed reduced Nogo-P3 amplitudes. For the entire group (n = 34) we found a negative correlation with the Barratt Impulsiveness Scale (BIS-10) and Becks's depression inventory (BDI). The present study is the first to examine Nogo-N2 and Nogo-P3 in BPD and provides further evidence for impaired response inhibition in BPD patients.

A Comparative Study on Carbohydrate Estimation: GoCARB vs. Dietitians

Directory of Open Access Journals (Sweden)

Maria F. Vasiloglou

2018-06-01

Full Text Available GoCARB is a computer vision-based smartphone system designed for individuals with Type 1 Diabetes to estimate plated meals’ carbohydrate (CHO content. We aimed to compare the accuracy of GoCARB in estimating CHO with the estimations of six experienced dietitians. GoCARB was used to estimate the CHO content of 54 Central European plated meals, with each of them containing three different weighed food items. Ground truth was calculated using the USDA food composition database. Dietitians were asked to visually estimate the CHO content based on meal photographs. GoCARB and dietitians achieved comparable accuracies. The mean absolute error of the dietitians was 14.9 (SD 10.12 g of CHO versus 14.8 (SD 9.73 g of CHO for the GoCARB (p = 0.93. No differences were found between the estimations of dietitians and GoCARB, regardless the meal size. The larger the size of the meal, the greater were the estimation errors made by both. Moreover, the higher the CHO content of a food category was, the more challenging its accurate estimation. GoCARB had difficulty in estimating rice, pasta, potatoes, and mashed potatoes, while dietitians had problems with pasta, chips, rice, and polenta. GoCARB may offer diabetic patients the option of an easy, accurate, and almost real-time estimation of the CHO content of plated meals, and thus enhance diabetes self-management.

Going Concern Disclosure for Local Governments

Directory of Open Access Journals (Sweden)

Nancy Chun Feng

2017-07-01

Full Text Available Going concern opinions (GCOs indicate that auditors have significant doubt about an entity’s ability to continue operation one year after the financial statement date. This study addresses the following research questions: What are the factors that motivate auditors to issue GCOs to governmental entities? Does a governmental entity disclose going concern uncertainty in the footnotes or the MD&A section of annual financial reports (AFRs either the year before or the year when the entity receives a GCO? To what extent does the entity disclose the GCO factors used by auditors? We find that auditors most often cited two reasons, “Deficiency in Funds” and “Losses or Revenue Declines,” accounting for the majority of reasons given for a going concern opinion. Further, the disclosure is most likely to be in the notes to the AFRs. In addition, we find that going concern reporting varies by auditor type (state auditors vs. public accounting firms, government size, and government type. We also find some evidence that going concern disclosures improve after the enactment of GASB No. 56. The results of our study should be of interest to stakeholders’ interested in lead indicators of fiscal distress.

Mastering concurrency in Go

CERN Document Server

Kozyra, Nathan

2014-01-01

A practical approach covering everything you need to know to get up and running with Go, starting with the basics and imparting increasingly more detail as the examples and topics become more complicated. The book utilizes a casual, conversational style, rife with actual code and historical anecdotes for perspective, as well as usable and extensible example applications. This book is intended for systems developers and programmers with some experience in either Go and/or concurrent programming who wish to become fluent in building high-performance applications that scale by leveraging single-c

Hyperreality: Pemaknaan dalam Penggunaan Game Pokemon Go

OpenAIRE

Tuela, Michael; Susilo, Daniel

2017-01-01

Penelitian  ini  bertujuan  untuk  mengetahui  hiperrealitas  dalam  fenomena  game  Pokemon  Go.  Untuk  mengetahui  lebih  dalam  bagaimana  pengaruh  penggunaan  teknologi  augmented  reality  pada  sebuah  game  Pokemon  Go  dan  juga  sudut  pandang  pemain  game  Pokemon  Go  yang  ikut  merasakan  fenomena  game  Pokemon  Go  dan  serta  pemahaman  pemain  game  Pokemon  terhadap  game  Pokemon  Go. Pendekatan  penelitian  ini  menggunakan  pendekatan  metode  penelitian  kualitatif  y...

Attention and gaze shifting in dual-task and go/no-go performance with vocal responding

NARCIS (Netherlands)

Lamers, M.J.M.; Roelofs, A.P.A.

2011-01-01

Evidence from go/no-go performance on the Eriksen flanker task with manual responding suggests that individuals gaze at stimuli just as long as needed to identify them (e.g.. Sanders, 1998). In contrast, evidence from dual-task performance with vocal responding suggests that gaze shifts occur after

[Effects of an implicit internal working model on attachment in information processing assessed using Go/No-Go Association Task].

Science.gov (United States)

Fujii, Tsutomu; Uebuchi, Hisashi; Yamada, Kotono; Saito, Masahiro; Ito, Eriko; Tonegawa, Akiko; Uebuchi, Marie

2015-06-01

The purposes of the present study were (a) to use both a relational-anxiety Go/No-Go Association Task (GNAT) and an avoidance-of-intimacy GNAT in order to assess an implicit Internal Working Model (IWM) of attachment; (b) to verify the effects of both measured implicit relational anxiety and implicit avoidance of intimacy on information processing. The implicit IWM measured by GNAT differed from the explicit IWM measured by questionnaires in terms of the effects on information processing. In particular, in subliminal priming tasks involving with others, implicit avoidance of intimacy predicted accelerated response times with negative stimulus words about attachment. Moreover, after subliminally priming stimulus words about self, implicit relational anxiety predicted delayed response times with negative stimulus words about attachment.

Go/No Go task performance predicts cortical thickness in the caudal inferior frontal gyrus in young adults with and without ADHD.

Science.gov (United States)

Newman, Erik; Jernigan, Terry L; Lisdahl, Krista M; Tamm, Leanne; Tapert, Susan F; Potkin, Steven G; Mathalon, Daniel; Molina, Brooke; Bjork, James; Castellanos, F Xavier; Swanson, James; Kuperman, Joshua M; Bartsch, Hauke; Chen, Chi-Hua; Dale, Anders M; Epstein, Jeffery N; Group, Mta Neuroimaging

2016-09-01

Response inhibition deficits are widely believed to be at the core of Attention-Deficit Hyperactivity Disorder (ADHD). Several studies have examined neural architectural correlates of ADHD, but research directly examining structural correlates of response inhibition is lacking. Here we examine the relationship between response inhibition as measured by a Go/No Go task, and cortical surface area and thickness of the caudal inferior frontal gyrus (cIFG), a region implicated in functional imaging studies of response inhibition, in a sample of 114 young adults with and without ADHD diagnosed initially during childhood. We used multiple linear regression models to test the hypothesis that Go/No Go performance would be associated with cIFG surface area or thickness. Results showed that poorer Go/No Go performance was associated with thicker cIFG cortex, and this effect was not mediated by ADHD status or history of substance use. However, independent of Go/No Go performance, persistence of ADHD symptoms and more frequent cannabis use were associated with thinner cIFG. Go/No Go performance was not associated with cortical surface area. The association between poor inhibitory functioning and thicker cIFG suggests that maturation of this region may differ in low performing participants. An independent association of persistent ADHD symptoms and frequent cannabis use with thinner cIFG cortex suggests that distinct neural mechanisms within this region may play a role in inhibitory function, broader ADHD symptomatology, and cannabis use. These results contribute to Research Domain Criteria (RDoC) by revealing novel associations between neural architectural phenotypes and basic neurobehavioral processes measured dimensionally.

MetaGO: Predicting Gene Ontology of Non-homologous Proteins Through Low-Resolution Protein Structure Prediction and Protein-Protein Network Mapping.

Science.gov (United States)

Zhang, Chengxin; Zheng, Wei; Freddolino, Peter L; Zhang, Yang

2018-03-10

Homology-based transferal remains the major approach to computational protein function annotations, but it becomes increasingly unreliable when the sequence identity between query and template decreases below 30%. We propose a novel pipeline, MetaGO, to deduce Gene Ontology attributes of proteins by combining sequence homology-based annotation with low-resolution structure prediction and comparison, and partner's homology-based protein-protein network mapping. The pipeline was tested on a large-scale set of 1000 non-redundant proteins from the CAFA3 experiment. Under the stringent benchmark conditions where templates with >30% sequence identity to the query are excluded, MetaGO achieves average F-measures of 0.487, 0.408, and 0.598, for Molecular Function, Biological Process, and Cellular Component, respectively, which are significantly higher than those achieved by other state-of-the-art function annotations methods. Detailed data analysis shows that the major advantage of the MetaGO lies in the new functional homolog detections from partner's homology-based network mapping and structure-based local and global structure alignments, the confidence scores of which can be optimally combined through logistic regression. These data demonstrate the power of using a hybrid model incorporating protein structure and interaction networks to deduce new functional insights beyond traditional sequence homology-based referrals, especially for proteins that lack homologous function templates. The MetaGO pipeline is available at http://zhanglab.ccmb.med.umich.edu/MetaGO/. Copyright © 2018. Published by Elsevier Ltd.

Going Concern i revisionsprocessen [del 1

DEFF Research Database (Denmark)

Hartmann, Stig; Haraszuk, Anni

2012-01-01

Nærværende artikel er den første af to planlagte, der vil blive bragt i Revision & Regnskabsvæsen. Det er artiklernes overordnede ide at besvare følgende spørgsmål: Hvad er nøgleelementerne i god revisorskik anno 2012 i forhold til Going Concern vurdering i revisionsprocessen? Hvordan eksekveres...... god revisorskik i forhold til Going Concern i 2012 samt 2013 og fremadrettet? Hvem er nøgleinteressenterne og hvilken roller spiller de i udviklingen af god revisorskik, indenfor Going Concern i erklæringer med høj grad af sikkerhed? Hvordan kan revisionsvirksomhedens interne kvalitetsstyringssystem...... designes i forhold til Going Concern for at leve op til god revisorskik, samtidigt med at revisor skal drive en fornuftig forretning?...

pcaGoPromoter--an R package for biological and regulatory interpretation of principal components in genome-wide gene expression data

DEFF Research Database (Denmark)

Hansen, Morten; Gerds, Thomas Alexander; Nielsen, Ole Haagen

2012-01-01

Analyzing data obtained from genome-wide gene expression experiments is challenging due to the quantity of variables, the need for multivariate analyses, and the demands of managing large amounts of data. Here we present the R package pcaGoPromoter, which facilitates the interpretation of genome.......g., cell cycle progression and the predicted involvement of expected transcription factors, including E2F. In addition, unexpected results, e.g., cholesterol synthesis in serum-depleted cells and NF-¿B activation in inhibitor treated cells, were noted. In summary, the pcaGoPromoter R package provides...

Co-LncRNA: investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways based on human RNA-Seq data.

Science.gov (United States)

Zhao, Zheng; Bai, Jing; Wu, Aiwei; Wang, Yuan; Zhang, Jinwen; Wang, Zishan; Li, Yongsheng; Xu, Juan; Li, Xia

2015-01-01

Long non-coding RNAs (lncRNAs) are emerging as key regulators of diverse biological processes and diseases. However, the combinatorial effects of these molecules in a specific biological function are poorly understood. Identifying co-expressed protein-coding genes of lncRNAs would provide ample insight into lncRNA functions. To facilitate such an effort, we have developed Co-LncRNA, which is a web-based computational tool that allows users to identify GO annotations and KEGG pathways that may be affected by co-expressed protein-coding genes of a single or multiple lncRNAs. LncRNA co-expressed protein-coding genes were first identified in publicly available human RNA-Seq datasets, including 241 datasets across 6560 total individuals representing 28 tissue types/cell lines. Then, the lncRNA combinatorial effects in a given GO annotations or KEGG pathways are taken into account by the simultaneous analysis of multiple lncRNAs in user-selected individual or multiple datasets, which is realized by enrichment analysis. In addition, this software provides a graphical overview of pathways that are modulated by lncRNAs, as well as a specific tool to display the relevant networks between lncRNAs and their co-expressed protein-coding genes. Co-LncRNA also supports users in uploading their own lncRNA and protein-coding gene expression profiles to investigate the lncRNA combinatorial effects. It will be continuously updated with more human RNA-Seq datasets on an annual basis. Taken together, Co-LncRNA provides a web-based application for investigating lncRNA combinatorial effects, which could shed light on their biological roles and could be a valuable resource for this community. Database URL: http://www.bio-bigdata.com/Co-LncRNA/. © The Author(s) 2015. Published by Oxford University Press.

Pokémon-Go: Why Augmented Reality Games Offer Insights for Enhancing Public Health Interventions on Obesity-Related Diseases.

Science.gov (United States)

Wong, Ming Chao; Turner, Paul; MacIntyre, Kate; Yee, Kwang Chien

2017-01-01

Stimulating widespread interests of the population to participate in behavioural changes through information and technology has been an aim of much health informatics research. The recent widespread participation of the augmented reality game Pokémon Go which encourages exercises, provides significant insights into the potential of information technology to improve healthcare intervention on obesity-related disease. Does Pokémon Go point to another way of achieving health benefits using mobile devices? This paper analyses the features of Pokémon Go in relation to potential health benefits. This paper suggests from the perspective of a user on changes to the game that potentially could help with obesity, mental health cardiovascular health and vitamin D deficiencies. While the impact of augmented reality games on improving exercises might be substantial, the question of sustainability and likely long-term health outcomes remain debatable. The rapid uptake of Pokémon Go by the population around the world, however, should serve as a useful lesson for information and technological design to improve outcomes obesity-related diseases in the future.

In-situ conversion of rGO/Ni2P composite from GO/Ni-MOF precursor with enhanced electrochemical property

Science.gov (United States)

Lv, Zijian; Zhong, Qin; Bu, Yunfei

2018-05-01

Owing to the metalloid characteristic and superior electrical conductivity, the metal phosphides have received increasing interests in energy storage systems. Here, xrGO/Ni2P composites are successfully synthesized via an In-situ phosphorization process with GO/Ni-MOF as precursors. Compared to pure Ni2P, the xrGO/Ni2P composites appear enhanced electrochemical properties in terms of the specific capacitance and cycling performance as electrodes for supercapacitors. Especially, the 2rGO/Ni2P electrode shows a highest specific capacitance of 890 F g-1 at 1 A g-1 among the obtained composites. The enhancement can be attributed to the inherited structure from Ni-MOF and the well assembled of rGO and Ni2P through the In-situ conversion process. Moreover, when applied as positive electrode in a hybrid supercapacitor, an energy density of 35.9 W h kg-1 at a power density of 752 W kg-1 has been achieved. This work provides an In-situ conversion strategy for the synthesis of rGO/Ni2P composite which might be a promising electrode material for SCs.

GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images.

Science.gov (United States)

Trinh, Anne; Rye, Inga H; Almendro, Vanessa; Helland, Aslaug; Russnes, Hege G; Markowetz, Florian

2014-08-26

Molecular analysis has revealed extensive intra-tumor heterogeneity in human cancer samples, but cannot identify cell-to-cell variations within the tissue microenvironment. In contrast, in situ analysis can identify genetic aberrations in phenotypically defined cell subpopulations while preserving tissue-context specificity. GoIFISHGoIFISH is a widely applicable, user-friendly system tailored for the objective and semi-automated visualization, detection and quantification of genomic alterations and protein expression obtained from fluorescence in situ analysis. In a sample set of HER2-positive breast cancers GoIFISHGoIFISH is highly robust in visual analysis and its accuracy compares favorably to other leading image analysis methods. GoIFISHGoIFISH is freely available at www.sourceforge.net/projects/goifish/.

Individual classification of ADHD children by right prefrontal hemodynamic responses during a go/no-go task as assessed by fNIRS

Directory of Open Access Journals (Sweden)

Yukifumi Monden

2015-01-01

Full Text Available While a growing body of neurocognitive research has explored the neural substrates associated with attention deficit hyperactive disorder (ADHD, an objective biomarker for diagnosis has not been established. The advent of functional near-infrared spectroscopy (fNIRS, which is a noninvasive and unrestrictive method of functional neuroimaging, raised the possibility of introducing functional neuroimaging diagnosis in young ADHD children. Previously, our fNIRS-based measurements successfully visualized the hypoactivation pattern in the right prefrontal cortex during a go/no-go task in ADHD children compared with typically developing control children at a group level. The current study aimed to explore a method of individual differentiation between ADHD and typically developing control children using multichannel fNIRS, emphasizing how spatial distribution and amplitude of hemodynamic response are associated with inhibition-related right prefrontal dysfunction. Thirty ADHD and thirty typically developing control children underwent a go/no-go task, and their cortical hemodynamics were assessed using fNIRS. We explored specific regions of interest (ROIs and cut-off amplitudes for cortical activation to distinguish ADHD children from control children. The ROI located on the border of inferior and middle frontal gyri yielded the most accurate discrimination. Furthermore, we adapted well-formed formulae for the constituent channels of the optimized ROI, leading to improved classification accuracy with an area under the curve value of 85% and with 90% sensitivity. Thus, the right prefrontal hypoactivation assessed by fNIRS would serve as a potentially effective biomarker for classifying ADHD children at the individual level.

Motor Impulsivity during Childhood and Adolescence: A Longitudinal Biometric Analysis of the Go/No-Go Task in 9- to 18-Year-Old Twins

Science.gov (United States)

Bezdjian, Serena; Tuvblad, Catherine; Wang, Pan; Raine, Adrian; Baker, Laura A.

2014-01-01

In the present study, we investigated genetic and environmental effects on motor impulsivity from childhood to late adolescence using a longitudinal sample of twins from ages 9 to 18 years. Motor impulsivity was assessed using errors of commission (no-go errors) in a visual go/no-go task at 4 time points: ages 9-10, 11-13, 14-15, and 16-18 years.…

GoPhast: a graphical user interface for PHAST

Science.gov (United States)

Winston, Richard B.

2006-01-01

GoPhast is a graphical user interface (GUI) for the USGS model PHAST. PHAST simulates multicomponent, reactive solute transport in three-dimensional, saturated, ground-water flow systems. PHAST can model both equilibrium and kinetic geochemical reactions. PHAST is derived from HST3D (flow and transport) and PHREEQC (geochemical calculations). The flow and transport calculations are restricted to constant fluid density and constant temperature. The complexity of the input required by PHAST makes manual construction of its input files tedious and error-prone. GoPhast streamlines the creation of the input file and helps reduce errors. GoPhast allows the user to define the spatial input for the PHAST flow and transport data file by drawing points, lines, or polygons on top, front, and side views of the model domain. These objects can have up to two associated formulas that define their extent perpendicular to the view plane, allowing the objects to be three-dimensional. Formulas are also used to specify the values of spatial data (data sets) both globally and for individual objects. Objects can be used to specify the values of data sets independent of the spatial and temporal discretization of the model. Thus, the grid and simulation periods for the model can be changed without respecifying spatial data pertaining to the hydrogeologic framework and boundary conditions. This report describes the operation of GoPhast and demonstrates its use with examples. GoPhast runs on Windows 2000, Windows XP, and Linux operating systems.

Optimization of culture conditions and medium composition for the production of micrococcin GO5 by Micrococcus sp. GO5.

Science.gov (United States)

Kim, Mi-Hee; Kong, Yoon-Jung; Baek, Hong; Hyun, Hyung-Hwan

2006-01-02

To enhance the production of micrococcin GO5, a bacteriocin produced by Micrococcus sp. GO5, cultivation conditions and medium composition were optimized. The optimal initial pH and temperature for bacteriocin production were 7.0-9.0 and 37 degrees C, respectively. Micrococcus sp. GO5 displayed the highest micrococcin GO5 activity when grown in modified MRS medium that contained lactose or sucrose, rather than glucose, as a carbon source. The maximum bacteriocin activity was obtained in modified MRS medium containing 0.5% tryptone and 1.0% yeast extract as nitrogen sources instead of the other nitrogen sources present in MRS medium. Bacteriocin production was greatly affected by the concentration of K(2)HPO(4); strain GO5 produced eight-fold more bacteriocin in medium containing 2.0-2.5% K(2)HPO(4) than in medium containing 0.2% K(2)HPO(4). The optimal concentration of MgSO(4).7H(2)O for bacteriocin production was 0.5%. The production of micrococcin GO5 was increased 32-fold in shake flask culture and 16-fold in a bioreactor using the optimized medium (TY medium), compared with culturing in MRS medium.

Zur Verwendung der Partikel go in Modalverbkonstruktionen

Directory of Open Access Journals (Sweden)

von Rotz, Ruth

2011-01-01

Full Text Available This article focusses on the use of the particle go in Swiss German modal verb constructions. The particle go is associated with the verb gaa 'go'. The research question is whether the particle go is solely used together with verbs entailing movement from one point to another. The presented results arise from questionnaire data and subsequent interviews. The area under investigation is situated in the highlands of the Canton St. Gallen in the East of Switzerland namely the villages Mels, Sargans, Wangs and Bad Ragaz.

Going Green

Centers for Disease Control (CDC) Podcasts

2008-04-18

This podcast is for a general audience and provides information on how to recycle, re-use, and restore. It also covers the benefits of “Going Green" on the environment, health, and social interaction.  Created: 4/18/2008 by National Center for Environmental Health (NCEH), ATSDR.   Date Released: 5/8/2008.

GoCxx: a tool to easily leverage C++ legacy code for multicore-friendly Go libraries and frameworks

International Nuclear Information System (INIS)

Binet, Sébastien

2012-01-01

Current HENP libraries and frameworks were written before multicore systems became widely deployed and used. From this environment, a ‘single-thread’ processing model naturally emerged but the implicit assumptions it encouraged are greatly impairing our abilities to scale in a multicore/manycore world. Writing scalable code in C++ for multicore architectures, while doable, is no panacea. Sure, C++11 will improve on the current situation (by standardizing on std::thread, introducing lambda functions and defining a memory model) but it will do so at the price of complicating further an already quite sophisticated language. This level of sophistication has probably already strongly motivated analysis groups to migrate to CPython, hoping for its current limitations with respect to multicore scalability to be either lifted (Grand Interpreter Lock removal) or for the advent of a new Python VM better tailored for this kind of environment (PyPy, Jython, …) Could HENP migrate to a language with none of the deficiencies of C++ (build time, deployment, low level tools for concurrency) and with the fast turn-around time, simplicity and ease of coding of Python? This paper will try to make the case for Go - a young open source language with built-in facilities to easily express and expose concurrency - being such a language. We introduce GoCxx, a tool leveraging gcc-xml's output to automatize the tedious work of creating Go wrappers for foreign languages, a critical task for any language wishing to leverage legacy and field-tested code. We will conclude with the first results of applying GoCxx to real C++ code.

Self-Rated Attentiveness Interacts with Transcranial Direct Current Stimulation and Noise Stimulation in Reaction Time in a Go/No-Go Task.

Science.gov (United States)

Sikström, Sverker; Jürgensen, Anna-Maria; Haghighi, Maryam; Månsson, Daniel; Smidelik, David; Habekost, Thomas

2016-01-01

Previous research has found that stimulating inattentive people with auditory white noise induces enhancement in cognitive performance. This enhancement is believed to occur due to a statistical phenomenon called stochastic resonance, where noise increases the probability of a signal passing the firing threshold in the neural cells. Here we investigate whether people with low attentiveness benefit to a larger extent than attentive people from stimulation by auditory white noise and transcranial direct current stimulation (tDCS). The results show, for both auditory noise and tDCS stimulation, that the changes in performance relative to nonstimulation correlate with the degree of attentiveness in a Go/No-Go task, but not in a N-back task. These results suggest that the benefit of tDCS may interact with inattentiveness.

goGPS: open source software for enhancing the accuracy of low-cost receivers by single-frequency relative kinematic positioning

International Nuclear Information System (INIS)

Realini, Eugenio; Reguzzoni, Mirko

2013-01-01

goGPS is a free and open source satellite positioning software package aiming to provide a collaborative platform for research and teaching purposes. It was first published in 2009 and since then several related projects are on-going. Its objective is the investigation of strategies for enhancing the accuracy of low-cost single-frequency GPS receivers, mainly by relative positioning with respect to a base station and by a tailored extended Kalman filter working directly on code and phase observations. In this paper, the positioning algorithms implemented in goGPS are presented, emphasizing the modularity of the software design; two specific strategies to support the navigation with low-cost receivers are also proposed and discussed, namely an empirical observation weighting function calibrated on the receiver signal-to-noise ratio and the inclusion of height information from a digital terrain model as an additional observation in the Kalman filter. The former is crucial when working with high-sensitivity receivers, while the latter can significantly improve the positioning in the vertical direction. The overall goGPS positioning accuracy is assessed by comparison with a dual-frequency receiver and with the positioning computed by a standard low-cost receiver. The benefits of the calibrated weighting function and the digital terrain model are investigated by an experiment in a dense urban environment. It comes out that the use of goGPS and low-cost receivers leads to results comparable with those obtained by higher level receivers; goGPS has good performances also in a dense urban environment, where its additional features play an important role. (paper)

Going Green

Science.gov (United States)

Witkowsky, Kathy

2009-01-01

Going green saves money and can even make money. Sustainable practices promote better health, less absenteeism, and more productivity. They also attract students, who are paying increasing attention to schools' environmental policies. Beyond being the smart thing to do, administrators at the University of Washington say repeatedly, it's the right…

The Three Models of Emotional Intelligence and Performance in a Hot and Cool go/no-go Task in Undergraduate Students

Science.gov (United States)

Gutiérrez-Cobo, María J.; Cabello, Rosario; Fernández-Berrocal, Pablo

2017-01-01

Emotional intelligence (EI), or the ability to perceive, use, understand and regulate emotions, appears to be helpful in the performance of “hot” (i.e., emotionally laden) cognitive tasks when using performance-based ability models, but not when using self-report EI models. The aim of this study is to analyze the relationship between EI (as measured through a performance-based ability test, a self-report mixed test and a self-report ability test) and cognitive control ability during the performance of hot and “cool” (i.e., non-emotionally laden) “go/no-go” tasks. An experimental design was used for this study in which 187 undergraduate students (25% men) with a mean age of 21.93 years (standard deviation [SD] = 3.8) completed the three EI tests of interest (Mayer-Salovey-Caruso Emotional Intelligence Test [MSCEIT], Trait Meta-Mood Scale [TMMS] and Emotional Quotient Inventory–Short Form [EQi:S]) as well as go/no-go tasks using faces and geometric figures as stimuli. The results provide evidence for negative associations between the “managing” branch of EI measured through the performance-based ability test of EI and the cognitive control index of the hot go/no-go task, although similar evidence was not found when using the cool task. Further, the present study failed to observe consistent results when using the self-report EI instruments. These findings are discussed in terms of both the validity and implications of the various EI models. PMID:28275343

Fabrication of TiO{sub 2} nanorod assembly grafted rGO (rGO@TiO{sub 2}-NR) hybridized flake-like photocatalyst

Energy Technology Data Exchange (ETDEWEB)

Lv, Kangle, E-mail: lvkangle@mail.scuec.edu.cn [Department of Science and Environmental Studies, The Hong Kong Institute of Education, Taipo, N.T., Hong Kong (China); Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission and Ministry of Education, College of Resources and Environmental Science, South-Central University for Nationalities, Wuhan 430074 (China); Fang, Shun; Si, Lingling; Xia, Yang [Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission and Ministry of Education, College of Resources and Environmental Science, South-Central University for Nationalities, Wuhan 430074 (China); Ho, Wingkei, E-mail: keithho@ied.edu.hk [Department of Science and Environmental Studies, The Hong Kong Institute of Education, Taipo, N.T., Hong Kong (China); Li, Mei [Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission and Ministry of Education, College of Resources and Environmental Science, South-Central University for Nationalities, Wuhan 430074 (China)

2017-01-01

Highlights: • TiO{sub 2} nanorod assembly grafted with GO hybrid was successfully fabricated. • TiO{sub 2} nanorods can reduce the aggregation of TiO{sub 2} nanoparticles on graphene. • This unique structure facilitates the injection of electron from TiO{sub 2} to graphene. - Abstract: To efficiently separate the photo-generated electron–hole pairs of TiO{sub 2} hybrid, anatase TiO{sub 2} nanorod assembly grafted reduced graphene oxides (rGO@TiO{sub 2}-NR) hybrid was successfully fabricated using potassium titanium oxalate (PTO) and graphene oxides (GO) as starting materials and diethylene glycol (DEG) as reductant. The effect of GO content on the structure and photocatalytic activity of rGO@TiO{sub 2}-NR composite was systematically studied. Results show that, in the absence of GO, only TiO{sub 2} microsphere assembly is obtained from TiO{sub 2} nanorods. The presence of GO results in the formation of a flake-like TiO{sub 2}-nanorod-assembled grafted rGO hybrid. The photocatalytic activity of rGO@TiO{sub 2}-NR composite increases first and then decreases with increase in the amount of GO from 0 wt.% to 10 wt.%. The hybridized S4 sample prepared with 4 wt.% GO possesses the highest photocatalytic activity with a constant rate of 0.039 min{sup −1} in the photocataytic degradation of Brilliant X-3B dye (X3B); this sample was enhanced more than three times when compared with pure TiO{sub 2} sample (0.012 min{sup −1}). The enhanced photocatalytic activity of the rGO@TiO{sub 2}-NR hybrid was attributed to the strong interaction between TiO{sub 2} nanorods and rGO. The unique hierarchical structure of 1D nanorod assembly TiO{sub 2}–rGO flakes facilitates the injection and transfer of photo-generated electrons from TiO{sub 2} to graphene, thus retarding the recombination of electron–hole pairs and enhancing the photocatalytic activity. The enlarged BET surface areas, not only increasing the number of active sites, but also facilitating the adsorption of

Go4Life

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Full Text Available ... strength! Stronger muscles can make it easier to do everyday things like get up from a chair, ... 797 views Trainer Sandy shows Linda how to do lower body exercises in her office with Go4Life's ...

Causal factors in accidents of high-speed craft and conventional ocean-going vessels

International Nuclear Information System (INIS)

Antao, Pedro; Guedes Soares, C.

2008-01-01

An analysis of 40 ocean-going commercial vessel accidents is compared with the study of a similar number of high-speed crafts (HSCs) accidents, using in both cases a methodology that highlights the sequence of events leading to the accident and identifies the associated latent or causal factors. The main objective of this study was to identify and understand the difference in the pattern of causal factors associated with HSC accidents, as compared with the more traditional ocean-going ships. From the analysis one can see that the HSC accidents are mainly related to bridge personnel and operations, where the human element is the key factor identified as being responsible for the majority of the accidents. When compared with ocean-going commercial vessels, it is clear that navigational equipment and procedures have a larger preponderance in terms of the occurrence of accidents of HSC and particular attention should be given to these issues

Fabrication of GO/Cement Composites by Incorporation of Few-Layered GO Nanosheets and Characterization of Their Crystal/Chemical Structure and Properties.

Science.gov (United States)

Lv, Shenghua; Hu, Haoyan; Zhang, Jia; Luo, Xiaoqian; Lei, Ying; Sun, Li

2017-12-18

Original graphene oxide (GO) nanosheets were prepared using the Hummers method and found to easily aggregate in aqueous and cement composites. Using carboxymethyl chitosan (CCS) as a dispersant, few-layered GO nanosheets (1-2 layers) were obtained by forming CCS/GO intercalation composites. The testing results indicated that the few-layered GO nanosheets could uniformly spread, both in aqueous and cement composites. The cement composites were prepared with GO dosages of 0.03%, 0.05% and 0.07% and we found that they had a compact microstructure in the whole volume. A special feature was determined, namely that the microstructures consisted of regular-shaped crystals created by self-crosslinking. The X-ray diffraction (XRD) results indicated that there was a higher number of cement hydration crystals in GO/cement composites. Meanwhile, we also found that partially-amorphous Calcium-Silicate-Hydrate (C-S-H) gel turned into monoclinic crystals. At 28 days, the GO/cement composites reached the maximum compressive and flexural strengths at a 0.05% dosage. These strengths were 176.64 and 31.67 MPa and, compared with control samples, their increased ratios were 64.87% and 149.73%, respectively. Durability parameters, such as penetration, freeze-thaw, carbonation, drying-shrinkage value and pore structure, showed marked improvement. The results indicated that it is possible to obtain cement composites with a compact microstructure and with high performances by introducing CCS/GO intercalation composites.

Preparation and Drug-Delivery Properties of HKUST-1/GO Hybrid.

Science.gov (United States)

Sun, Ke Ke; Li, Ling; He, Yu Qi; Fan, Lu; Wu, Ya Qi; Liu, Li

2016-01-01

A hybrid HKUST-1/GO composite was synthesized and its drug loading and drug release abilities were investigated. The adsorption of IBU (ibuprofen) onto the surface of HKUST-1/GO and HKUST-1 composites was compared, and it was found that the addition of GO enhanced both IBU loading and stability. The addition of GO also enhanced the specific surface area. Drug release experiments on IBU loaded HKUST-1 and HKUST-1/GO were conducted, and it was found that drug release of HKUST-1/GO was slower, which can be explained by the hydrogen bonding between GO and IBU. It can be concluded that the addition of GO not only enhances drug loading, but can also achieve a more desirable slow-release of the drug.

Letting Go

Science.gov (United States)

Brazington, Alicia

2012-01-01

These days, branding is everything. Marketers go all out to position their product, control its image, and spin the message. For marketers at the nation's colleges and universities, the stakes are especially high. After all, they are entrusted with the image of institutions that have, in some cases, spent centuries building up their brand…

Isoflurane is a suitable alternative to ether for anesthetizing rats prior to euthanasia for gene expression analysis.

Science.gov (United States)

Nakatsu, Noriyuki; Igarashi, Yoshinobu; Aoshi, Taiki; Hamaguchi, Isao; Saito, Masumichi; Mizukami, Takuo; Momose, Haruka; Ishii, Ken J; Yamada, Hiroshi

2017-01-01

Diethyl ether (ether) had been widely used in Japan for anesthesia, despite its explosive properties and toxicity to both humans and animals. We also had used ether as an anesthetic for euthanizing rats for research in the Toxicogenomics Project (TGP). Because the use of ether for these purposes will likely cease, it is required to select an alternative anesthetic which is validated for consistency with existing TGP data acquired under ether anesthesia. We therefore compared two alternative anesthetic candidates, isoflurane and pentobarbital, with ether in terms of hematological findings, serum biochemical parameters, and gene expressions. As a result, few differences among the three agents were observed. In hematological and serum biochemistry analysis, no significant changes were found. In gene expression analysis, four known genes were extracted as differentially expressed genes in the liver of rats anesthetized with ether, isoflurane, or pentobarbital. However, no significant relationships were detected using gene ontology, pathway, or gene enrichment analyses by DAVID and TargetMine. Surprisingly, although it was expected that the lung would be affected by administration via inhalation, only one differentially expressed gene was extracted in the lung. Taken together, our data indicate that there are no significant differences among ether, isoflurane, and pentobarbital with respect to effects on hematological parameters, serum biochemistry parameters, and gene expression. Based on its smallest affect to existing data and its safety profile for humans and animals, we suggest isoflurane as a suitable alternative anesthetic for use in rat euthanasia in toxicogenomics analysis.

Go4Life

Medline Plus

Full Text Available ... is important because it can help reduce your risk for falls. 3:01 Play next Play now Go4Life Exercise--Stand on One Foot - Duration: 3 minutes, 1 second. National Institute ...

Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656

DEFF Research Database (Denmark)

Siebrands, Cornelia C; Schmitt, Nicole; Friederich, Patrick

2005-01-01

was to determine the effect of the mutations Y652A and F656A in the putative drug binding region of HERG on the inhibition by bupivacaine, ropivacaine, and mepivacaine. METHODS: The authors examined the inhibition of wild-type and mutant HERG channels, transiently expressed in Chinese hamster ovary cells...... by bupivacaine, ropivacaine, and mepivacaine. Whole cell patch clamp recordings were performed at room temperature. RESULTS: Inhibition of HERG wild-type and mutant channels by the different local anesthetics was concentration dependent, stereoselective, and reversible. The sensitivity decreased in the order...... bupivacaine > ropivacaine > mepivacaine for wild-type and mutant channels. The mutant channels were approximately 4-30 times less sensitive to the inhibitory action of the different local anesthetics than the wild-type channel. The concentration-response data were described by Hill functions (bupivacaine...

Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression

Directory of Open Access Journals (Sweden)

Yi Fan Teah

2017-10-01

Full Text Available The data presented in this article are related to the research article entitled “The effects of deoxyelephantopin on the cardiac delayed rectifier potassium channel current (IKr and human ether-a-go-go-related gene (hERG expression” (Y.F. Teah, M.A. Abduraman, A. Amanah, M.I. Adenan, S.F. Sulaiman, M.L. Tan [1], which the possible hERG blocking properties of deoxyelephantopin were investigated. This article describes the construction of human embryonic kidney 293 (HEK293 cells overexpressing HERG potassium channel and verification of the presence of hERG mRNA and protein expression in this recombinant cell line.

Molecular cloning and functional expression of the Equine K+ channel KV11.1 (Ether à Go-Go-related/KCNH2 gene) and the regulatory subunit KCNE2 from equine myocardium

DEFF Research Database (Denmark)

Pedersen, Philip Juul; Thomsen, Kirsten Brolin; Olander, Emma Rie

2015-01-01

and conventional PCR on mRNA purified from equine myocardial tissue. Equine KV11.1 and KCNE2 cDNA had a high homology to human genes (93 and 88%, respectively). Equine and human KV11.1 and KV11.1/KCNE2 were expressed in Xenopus laevis oocytes and investigated by two-electrode voltage-clamp. Equine KV11.1 currents...... were larger compared to human KV11.1, and the voltage dependence of activation was shifted to more negative values with V1/2 = -14.2±1.1 mV and -17.3±0.7, respectively. The onset of inactivation was slower for equine KV11.1 compared to the human homolog. These differences in kinetics may account...... for the larger amplitude of the equine current. Furthermore, the equine KV11.1 channel was susceptible to pharmacological block with terfenadine. The physiological importance of KV11.1 was investigated in equine right ventricular wedge preparations. Terfenadine prolonged action potential duration and the effect...

Talar Fractures in Children: A Possible Injury After Go-Karting Accidents

NARCIS (Netherlands)

Kamphuis, S.J.; Meijs, C.M.E.M.; Kleinveld, S.; Diekerhof, C.H.; Heijden, F.H. van der

2015-01-01

Go-karting is an increasingly popular high-energy sport enjoyed by both children and adults. Because of the speeds involved, accidents involving go-karts can lead to serious injury. We describe 6 talar fractures in 4 patients that resulted from go-karting accidents. Talar fractures can cause severe

Fabrication of PEDOT coated PVA-GO nanofiber for supercapacitor

International Nuclear Information System (INIS)

Mohd Abdah, Muhammad Amirul Aizat; Zubair, Nur Afifah; Azman, Nur Hawa Nabilah; Sulaiman, Yusran

2017-01-01

Conducting nanofibers comprised of poly(vinyl alcohol) (PVA)-graphene oxide (GO) nanofiber coated with poly(3,4-ethylenedioxythiophene) (PEDOT) for supercapacitor application was prepared through integrated techniques i.e. electrospinning and electrodeposition. The formation of smooth cross-linking nanofibers without beads proved that GO has uniformly distributed into PVA with an average diameter of 117 ± 32 nm. Field emission scanning electron microscopy (FESEM) images revealed that cauliflower-like structure of PEDOT grew well on the surface of PVA-GO nanofibers with high porosity. Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy proved the existence of PVA, GO, and PEDOT. PVA-GO/PEDOT nanocomposite showed the highest specific capacitance (224.27 F/g) compared to PEDOT (167.92 F/g) and PVA/PEDOT (182.73 F/g). PVA-GO/PEDOT nanocomposite exhibited 1.8 V wide operating potential windows which significantly can enhance its capacitive behaviour. PVA-GO/PEDOT nanocomposite has also demonstrated superior performance with the energy density and power density of 9.58 Wh/kg and 304.37 W/kg, respectively at 1.0 A/g current density. PVA-GO/PEDOT nanocomposite revealed the smallest resistance of charge transfer (R_c_t) and equivalent series resistance (ESR) indicating excellent charge propagation behaviour at the interfacial region. The composite exhibits a good capacity retention of 82.41% after 2000 CV cycles and further drops 11.27% after 5000 cycles caused by the swelling and shrinkage of the electrode material during the charging and discharging processes. - Highlights: • PVA-GO/PEDOT was prepared via electrospinning and electrodeposition. • PVA-GO/PEDOT displays high capacitance value with wide potential window of 1.8 V. • PVA-GO/PEDOT exhibits high energy and power density, low R_c_t and ESR.

Fabrication of PEDOT coated PVA-GO nanofiber for supercapacitor

Energy Technology Data Exchange (ETDEWEB)

Mohd Abdah, Muhammad Amirul Aizat; Zubair, Nur Afifah; Azman, Nur Hawa Nabilah [Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor (Malaysia); Sulaiman, Yusran, E-mail: yusran@upm.edu.my [Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor (Malaysia); Functional Device Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor (Malaysia)

2017-05-01

Conducting nanofibers comprised of poly(vinyl alcohol) (PVA)-graphene oxide (GO) nanofiber coated with poly(3,4-ethylenedioxythiophene) (PEDOT) for supercapacitor application was prepared through integrated techniques i.e. electrospinning and electrodeposition. The formation of smooth cross-linking nanofibers without beads proved that GO has uniformly distributed into PVA with an average diameter of 117 ± 32 nm. Field emission scanning electron microscopy (FESEM) images revealed that cauliflower-like structure of PEDOT grew well on the surface of PVA-GO nanofibers with high porosity. Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy proved the existence of PVA, GO, and PEDOT. PVA-GO/PEDOT nanocomposite showed the highest specific capacitance (224.27 F/g) compared to PEDOT (167.92 F/g) and PVA/PEDOT (182.73 F/g). PVA-GO/PEDOT nanocomposite exhibited 1.8 V wide operating potential windows which significantly can enhance its capacitive behaviour. PVA-GO/PEDOT nanocomposite has also demonstrated superior performance with the energy density and power density of 9.58 Wh/kg and 304.37 W/kg, respectively at 1.0 A/g current density. PVA-GO/PEDOT nanocomposite revealed the smallest resistance of charge transfer (R{sub ct}) and equivalent series resistance (ESR) indicating excellent charge propagation behaviour at the interfacial region. The composite exhibits a good capacity retention of 82.41% after 2000 CV cycles and further drops 11.27% after 5000 cycles caused by the swelling and shrinkage of the electrode material during the charging and discharging processes. - Highlights: • PVA-GO/PEDOT was prepared via electrospinning and electrodeposition. • PVA-GO/PEDOT displays high capacitance value with wide potential window of 1.8 V. • PVA-GO/PEDOT exhibits high energy and power density, low R{sub ct} and ESR.

The Othering in Kazuo Ishiguro’s Never Let Me Go

Directory of Open Access Journals (Sweden)

Matava Vichiensing

2017-08-01

Full Text Available In this article, I will investigate the concept of ‘othering’ originally as part of a post-colonial theory. This concept is interested in many academic areas, including a literary study. In Kazuo Ishiguro’s novel Never Let Me Go is about human clones raised for organs. The clones are excluded and discriminated to be ‘the other’ from the normal people. The manifestations of othering in Never Let Me Go can be presented in the forms of linguistic features, indoctrination, objectification, and assimilation. Although the othering phenomenon can be found in the reality, it can be appeared in literary texts as well. The findings show that the study of Kazuo Ishiguro’s Never Let Me Go helps us to understand and aware of how the negative consequences of the othering process affect undesirable treatments in the society as a whole.

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

DEFF Research Database (Denmark)

Engelbrechtsen, Line; Mahendran, Yuvaraj; Jonsson, Anna

2018-01-01

BACKGROUND: Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia. This is caused by a dysfun......BACKGROUND: Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia. This is caused...... by a dysfunctional Kv11.1 voltage-gated potassium channel. Based on these findings in patients with rare variants in hERG, we hypothesized that common variants in hERG may also lead to alterations in glucose homeostasis. Subsequently, we aimed to evaluate the effect of two common gain-of-function variants in hERG...... in hERG on QT-interval and circulation levels of incretins, insulin and glucagon. The Danish population-based Inter99 cohort (n = 5895) was used to assess the effect of common variants on QT-interval. The Danish ADDITION-PRO cohort was used (n = 1329) to study genetic associations with levels of GLP-1...

Zooming in on the cause of the perceptual load effect in the go/no-go paradigm.

Science.gov (United States)

Chen, Zhe; Cave, Kyle R

2016-08-01

Perceptual load theory (Lavie, 2005) claims that attentional capacity that is not used for the current task is allocated to irrelevant distractors. It predicts that if the attentional demands of the current task are high, distractor interference will be low. One particularly powerful demonstration of perceptual load effects on distractor processing relies on a go/no-go cue that is interpreted by either simple feature detection or feature conjunction (Lavie, 1995). However, a possible alternative interpretation of these effects is that the differential degree of distractor processing is caused by how broadly attention is allocated (attentional zoom) rather than to perceptual load. In 4 experiments, we show that when stimuli are arranged to equalize the extent of spatial attention across conditions, distractor interference varies little whether cues are defined by a simple feature or a conjunction, and that the typical perceptual load effect emerges only when attentional zoom can covary with perceptual load. These results suggest that attentional zoom can account for the differential degree of distractor processing traditionally attributed to perceptual load in the go/no-go paradigm. They also provide new insight into how different factors interact to control distractor interference. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

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Full Text Available ... Play next Play now How Alzheimer's Changes the Brain - Duration: 4 minutes. National Institute On Aging 36, ... views Trainer Sandy shows Leo how to improve his grip with this exercise from Go4Life. CC 2: ...

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GO-FAANG meeting

NARCIS (Netherlands)

Tuggle, Christopher K.; Giuffra, Elisabetta; White, Stephen N.; Clarke, Laura; Zhou, Huaijun; Ross, Pablo J.; Acloque, Hervé; Reecy, James M.; Archibald, Alan; Bellone, Rebecca R.; Boichard, Michèle; Chamberlain, Amanda; Cheng, Hans; Crooijmans, Richard P.M.A.; Delany, Mary E.; Finno, Carrie J.; Groenen, Martien A.M.; Hayes, Ben; Lunney, Joan K.; Petersen, Jessica L.; Plastow, Graham S.; Schmidt, Carl J.; Song, Jiuzhou; Watson, Mick

2016-01-01

The Functional Annotation of Animal Genomes (FAANG) Consortium recently held a Gathering On FAANG (GO-FAANG) Workshop in Washington, DC on October 7–8, 2015. This consortium is a grass-roots organization formed to advance the annotation of newly assembled genomes of domesticated and non-model

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Go home, gay boy! Or, why do Singaporean gay men prefer to "go home" and not "come out"?

Science.gov (United States)

Tan, Chris K K

2011-01-01

Anglo-American ontologies posit that gay men should come out to match their outer selves with their inner ones. In Confucianized Singapore, however, gay men refrain from coming out to their parents to avoid shaming their families. Instead, they couch their homosexuality in kinship terms and "go home" with their boyfriends (Chou, 2000). "Going home" gains familial acceptance, but it does not challenge mainstream discourses of homosexuality. By examining how Singaporean gay men negotiate their sexuality with their families, I question the validity of coming out and going home as both ontological discourses and strategies.

Large-scale inference of gene function through phylogenetic annotation of Gene Ontology terms: case study of the apoptosis and autophagy cellular processes.

Science.gov (United States)

Feuermann, Marc; Gaudet, Pascale; Mi, Huaiyu; Lewis, Suzanna E; Thomas, Paul D

2016-01-01

We previously reported a paradigm for large-scale phylogenomic analysis of gene families that takes advantage of the large corpus of experimentally supported Gene Ontology (GO) annotations. This 'GO Phylogenetic Annotation' approach integrates GO annotations from evolutionarily related genes across ∼100 different organisms in the context of a gene family tree, in which curators build an explicit model of the evolution of gene functions. GO Phylogenetic Annotation models the gain and loss of functions in a gene family tree, which is used to infer the functions of uncharacterized (or incompletely characterized) gene products, even for human proteins that are relatively well studied. Here, we report our results from applying this paradigm to two well-characterized cellular processes, apoptosis and autophagy. This revealed several important observations with respect to GO annotations and how they can be used for function inference. Notably, we applied only a small fraction of the experimentally supported GO annotations to infer function in other family members. The majority of other annotations describe indirect effects, phenotypes or results from high throughput experiments. In addition, we show here how feedback from phylogenetic annotation leads to significant improvements in the PANTHER trees, the GO annotations and GO itself. Thus GO phylogenetic annotation both increases the quantity and improves the accuracy of the GO annotations provided to the research community. We expect these phylogenetically based annotations to be of broad use in gene enrichment analysis as well as other applications of GO annotations.Database URL: http://amigo.geneontology.org/amigo. © The Author(s) 2016. Published by Oxford University Press.

Implementing GoF Design Patterns in BETA

DEFF Research Database (Denmark)

Agerbo, Ellen; Cornils, Aino

1998-01-01

In this paper it is investigated how well the Beta supports the Design Patterns presented in [GoF 95]. We go through the language constructs in Beta to show which prove especially useful when implementing these Design Patterns. It is a fact that several of the Design Patterns found in [GoF 95] can...... be implemented in a simpler and more straightforward way in Beta than in ordinary OO-languages. This leads us to consider whether it is true that the more advanced OO-language one uses, the more of these Design Patterns are included directly in the language constructs....

Superlattice assembly of graphene oxide (GO) and titania nanosheets: fabrication, in situ photocatalytic reduction of GO and highly improved carrier transport

Science.gov (United States)

Cai, Xingke; Ma, Renzhi; Ozawa, Tadashi C.; Sakai, Nobuyuki; Funatsu, Asami; Sasaki, Takayoshi

2014-11-01

Two different kinds of two-dimensional (2D) materials, graphene oxide (GO) and titanium oxide nanosheets (Ti0.87O20.52-), were self-assembled layer-by-layer using a polycation as a linker into a superlattice film. Successful construction of an alternate molecular assembly was confirmed by atomic force microscopy and UV-visible absorption spectroscopy as well as X-ray diffraction analysis. Exposure of the resulting film to UV light effectively promoted photocatalytic reduction of GO as well as decomposition of the polycation, which are due to their intimate molecular-level contact. The reduction completed within 3 hours, bringing about a decrease of the sheet resistance by ~106. This process provides a clean and mild route to reduced graphene oxide (rGO), showing advantages over other chemical and thermal reduction processes. A field-effect-transistor device was fabricated using the resulting superlattice assembly of rGO/Ti0.87O20.52- as a channel material. The rGO in the film was found to work as a unipolar n-type conductor, which is in contrast to ambipolar or unipolar p-type behavior mostly reported for rGO films. This unique property may be associated with the electron doping effect from Ti0.87O20.52- nanosheets. A significant improvement in the conductance and electron carrier mobility by more than one order of magnitude was revealed, which may be accounted for by the heteroassembly with Ti0.87O20.52- nanosheets with a high dielectric constant as well as the better 2D structure of rGO produced via the soft photocatalytic reduction.Two different kinds of two-dimensional (2D) materials, graphene oxide (GO) and titanium oxide nanosheets (Ti0.87O20.52-), were self-assembled layer-by-layer using a polycation as a linker into a superlattice film. Successful construction of an alternate molecular assembly was confirmed by atomic force microscopy and UV-visible absorption spectroscopy as well as X-ray diffraction analysis. Exposure of the resulting film to UV light

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Budaya Populer Game Pokemon Go Sebagai Soft Diplomacy Jepang

OpenAIRE

Iqbal, Chadijah Isfariani

2016-01-01

Pokemon Go is a smartphone game that blends the real and digital worlds, tasking players with exploring their neighborhoods to find creatures and treasure for in-game use. This research describes the ways Japan uses its soft power in International coorporation relations, particulary through Pokemon Go's game. Based on Joseph S. Nye, Jr, the soft power defined as the ability of country to achieve its goal using cultural attraction rather than coercion and violence. After the World War II, Japa...

Electrochemical depositing rGO-Ti-rGO heterogeneous substrates with higher thermal conductivity and heat transfer performance compared to pure Ti.

Science.gov (United States)

Wang, Jing; Wang, Huatao; Zhang, Wenying; Yang, Xinyi; Wen, Guangwu; Wang, Yijie; Zhou, Weiwei

2017-02-17

Titanium (Ti) and its alloys are widely applied in many high strength, light weight applications, but their thermal conductivity is lower compared to that of other metals, which limits their further applications. In this paper, we demonstrated experimentally that rGO-Ti-rGO heterogeneous substrates with higher thermal conductivity, up to ∼38.8% higher than Ti, could be fabricated by electrochemical depositing rGO on their surface. The rGO layers are grown on the surface of Ti substrates, with appearance of bedclothes on the beds. The thickness of rGO layers is around 300-500 nm and around 600-1000 nm when deposited for 5 cycles and 10 cycles, respectively. According to the cooling experiment results, as-prepared Ti + rGO substrates can present excellent thermal conduction performance, and reduce the chip temperature close to 3.2 °C-13.1 °C lower than Ti alloy substrates with the heat flow density of 0.4-3.6 W cm -2 . Finally, the approach to electro-chemically deposit hundreds of nanometer rGO layers on the surface of Ti substrates can improve their thermal conductivity and heat transfer performance, which may have further application in the increasing thermal conduction of other metal-alloys, ceramics and polymers.

Do not respond! Doing the think/no-think and go/no-go task concurrently leads to memory impairment of unpleasant items during later recall

Directory of Open Access Journals (Sweden)

Cornelia eHerbert

2012-08-01

Full Text Available Previous research using neuroimaging methods proposed a link between mechanisms controlling motor response inhibition and suppression of unwanted memories. The present study investigated this hypothesis behaviorally by combining the think-no-think paradigm (TNT with a go/no-go motor inhibition task. Participants first learned unpleasant cue-target pairs. Cue words were then presented as go or no-go items in the TNT. Participants’ task was to respond to the cues and think of the target word aloud or to inhibit their response to the cue and the target word from coming to mind. Cued recall assessed immediately after the TNT revealed reduced recall performance for no-go targets compared to go targets or baseline cues, not presented in the TNT. The results demonstrate that doing the no-think and no-go task concurrently leads to memory suppression of unpleasant items during later recall. Results are discussed in line with recent empirical research and theoretical positions.

Original article Impulsive antisociality and executive control problems: evidence from go/no-go and stop-signal tasks

Directory of Open Access Journals (Sweden)

Jarosław M. Michałowski

2015-03-01

Full Text Available Background People with impulsive-antisocial traits may engage in unplanned behaviors that reduce their efficiency and may even result in harm to self and others. The present study aimed to investigate the relationship between executive control functions and impulsive antisociality, as assessed with the Psychopathic Personality Inventory (PPI. Using go/no-go and stop-signal paradigms, we examined whether healthy participants with high impulsive-antisocial traits would show delayed response inhibition and error monitoring deficits when compared to those reporting low levels of impulsive antisociality. Participants and procedure A total of 26 participants were recruited from different Warsaw universities based on the Impulsive Antisociality subscale scores of the PPI. Subjects scoring in the first quartile were assigned to the low and those with a score in the fourth quartile were selected for the high impulsivity group. All participants were tested with go/no-go and stop-signal tasks that were executed in a random order. Results Higher levels of impulsive-antisocial traits were associated with poorer executive control. In particular, high impulsive-antisocial individuals demonstrated reduced post-error slowing in response to go stimuli following an error and took longer to respond to the stop signal than the control group. The two groups did not differ in their performance accuracy. Conclusions The study extends previous findings regarding the relationship between impulsivity and executive control showing that non-clinical impulsive antisociality results in decreased conflict detection ability and delayed response inhibition. These problems may result in reduced executive effectiveness in everyday life situations.

The aggregate complexity of decisions in the game of Go

Science.gov (United States)

Harré, M. S.; Bossomaier, T.; Gillett, A.; Snyder, A.

2011-04-01

Artificial intelligence (AI) research is fast approaching, or perhaps has already reached, a bottleneck whereby further advancement towards practical human-like reasoning in complex tasks needs further quantified input from large studies of human decision-making. Previous studies in psychology, for example, often rely on relatively small cohorts and very specific tasks. These studies have strongly influenced some of the core notions in AI research such as the reinforcement learning and the exploration versus exploitation paradigms. With the goal of contributing to this direction in AI developments we present our findings on the evolution towards world-class decision-making across large cohorts of subjects in the formidable game of Go. Some of these findings directly support previous work on how experts develop their skills but we also report on several previously unknown aspects of the development of expertise that suggests new avenues for AI research to explore. In particular, at the level of play that has so far eluded current AI systems for Go, we are able to quantify the lack of `predictability' of experts and how this changes with their level of skill.

Concurrency at work with Go

CERN Document Server

CERN. Geneva

2017-01-01

High Energy and Nuclear Physics (HENP) libraries are now required to be increasingly multi-thread-safe, if not multi-thread-friendly and multi-threaded. This is usually done using the new constructs and library components offered by the C++11 and C++14 standards. These components are however quite low-level (threads, mutexes, locks, ...) and hard to use and compose, or easy to misuse. However, Go -- a somewhat new language -- provides a set of better building blocks for tackling concurrency: goroutines and channels. This language is now used by the cloud industry at large; docker/moby, rkt, Kubernetes, OpenShift, etc... are obvious flagships for Go. It is also used in other interesting places like SpaceX's telemetry monitoring system and in the New York Times', YouTube's or Disney's content delivery infrastructures. In this talk, we will describe the building blocks of Go and see how they are combined to easily create concurrent programs that grow with grace, are fast to compile and deploy, but also easy to...

Surgical video recording with a modified GoPro Hero 4 camera.

Science.gov (United States)

Lin, Lily Koo

2016-01-01

Surgical videography can provide analytical self-examination for the surgeon, teaching opportunities for trainees, and allow for surgical case presentations. This study examined if a modified GoPro Hero 4 camera with a 25 mm lens could prove to be a cost-effective method of surgical videography with enough detail for oculoplastic and strabismus surgery. The stock lens mount and lens were removed from a GoPro Hero 4 camera, and was refitted with a Peau Productions SuperMount and 25 mm lens. The modified GoPro Hero 4 camera was then fixed to an overhead surgical light. Camera settings were set to 1080p video resolution. The 25 mm lens allowed for nine times the magnification as the GoPro stock lens. There was no noticeable video distortion. The entire cost was less than 600 USD. The adapted GoPro Hero 4 with a 25 mm lens allows for high-definition, cost-effective, portable video capture of oculoplastic and strabismus surgery. The 25 mm lens allows for detailed videography that can enhance surgical teaching and self-examination.

A novel variable delay Go/No-Go task to study attention, motivation and working memory in the head-fixed rodent [v2; ref status: indexed, http://f1000r.es/1sn

Directory of Open Access Journals (Sweden)

Samuel D Dolzani

2014-03-01

Full Text Available In order to parse the causal elements underlying complex behaviors and decision-making processes, appropriate behavioral methods must be developed and used in concurrence with molecular, pharmacological, and electrophysiological approaches. Presented is a protocol for a novel Go/No-Go behavioral paradigm to study the brain attention and motivation/reward circuitry in awake, head-restrained rodents. This experimental setup allows: (1 Pharmacological and viral manipulation of various brain regions via targeted guide cannula; (2 Optogenetic cell-type specific activation and silencing with simultaneous electrophysiological recording and; (3 Repeated electrophysiological single and multiple unit recordings during ongoing behavior. The task consists of three components. The subject first makes an observing response by initiating a trial by lever pressing in response to distinctive Go or No-Go tones.  Then, after a variable delay period, the subject is presented with a challenge period cued by white noise during which they must respond with a lever press for the Go condition or withhold from lever pressing for the duration of the cue in the No-Go condition. After correctly responding during the challenge period (Challenge and a brief delay, a final reward tone of the same frequency as the initiation tone is presented and sucrose reward delivery is available and contingent upon lever pressing. Here, we provide a novel procedure and validating data set that allows researchers to study and manipulate components of behavior such as attention, motivation, impulsivity, and reward-related working memory during an ongoing operant behavioral task while limiting interference from non task-related behaviors.

The influence of ocean going ships on air quality

International Nuclear Information System (INIS)

Mooy, M.; Mennen, M.

2008-01-01

In this report we conclude that ocean going ships in the Netherlands contribute significantly to the emission of sulphur dioxide, nitrogen oxides, fine particulate matter and nickel compounds into the air. In spite of this, increased levels of nitrogen dioxide concentrations have only been found in the direct vicinity of major waterways and harbours in the Netherlands. Furthermore, the emission of fine particulate matter by ocean ships could also have a negative effect on human health. Both nitrogen dioxide and fine particulate matter can have negative health effects on people suffering from respiratory symptoms. The above is concluded by the National Institute for Public Health and the Environment (RIVM) in an exploratory study into the effects of shipping on air quality. The VROM-Inspectorate was the commissioning body. The reason for this study was the absence of complete understanding of the influence of ocean going ships on air quality and environment. Ocean ships are one of the least regulated types of air pollution sources. Standards for desired substance levels have only been set for sulphur in the Fuel (Sulphur Content) Decree. In the Netherlands only a few studies on this subject have been conducted. A complete picture on the influence of ocean going ships on air quality and environment is lacking. In order to gain more insight into the exact influence of ocean going vessels on the environment, a specific measuring campaign or thorough analysis of measured data is recommended [nl

The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task.

Science.gov (United States)

Brown, Brenna K; Murrell, Jill; Karne, Harish; Anand, Amit

2017-02-01

Dopaminergic brain circuits participate in emotional processing and impulsivity. The dopamine transporter (DAT) modulates dopamine reuptake. A variable number tandem repeat (VNTR) in the dopamine transporter gene (DAT1) affects DAT expression. The influence of DAT1 genotype on neural activation during emotional processing and impulse inhibition has not been examined. Forty-two healthy subjects were classified as 9DAT (n = 17) or 10DAT (n = 25) based on DAT1 genotype (9DAT = 9R/9R and 9R/10R; 10DAT = 10R/10R). Subjects underwent fMRI during non-emotional and emotional go/no-go tasks. Subjects were instructed to inhibit responses to letters, happy faces, or sad faces in separate blocks. Accuracy and reaction time did not differ between groups. Within group results showed activation in regions previously implicated in emotional processing and response inhibition. Between groups results showed increased activation in 9DAT individuals during inhibition. During letter inhibition, 9DAT individuals exhibited greater activation in right inferior parietal regions. During sad inhibition, 9DAT Individuals exhibited greater activation in frontal, posterior cingulate, precuneus, right cerebellar, left paracentral, and right occipital brain regions. The interaction between DAT genotype and response type in sad versus letter stimuli showed increased activation in 9DAT individuals during sad no-go responses in the anterior cingulate cortex, extending into frontal-orbital regions. 9DAT individuals have greater activation than 10DAT individuals during neutral and sad inhibition, showing that genotypic variation influencing basal dopamine levels can alter the neural basis of emotional processing and response inhibition. This may indicate that 9R carriers exert more effort to overcome increased basal dopamine activation when inhibiting responses in emotional contexts.

Chocolate equals stop. Chocolate-specific inhibition training reduces chocolate intake and go associations with chocolate.

Science.gov (United States)

Houben, Katrijn; Jansen, Anita

2015-04-01

Earlier research has demonstrated that food-specific inhibition training wherein food cues are repeatedly and consistently mapped onto stop signals decreases food intake and bodyweight. The mechanisms underlying these training effects, however, remain unclear. It has been suggested that consistently pairing stimuli with stop signals induces automatic stop associations with those stimuli, thereby facilitating automatic, bottom-up inhibition. This study examined this hypothesis with respect to food-inhibition training. Participants performed a training that consistently paired chocolate with no go cues (chocolate/no-go) or with go cues (chocolate/go). Following training, we measured automatic associations between chocolate and stop versus go, as well as food intake and desire to eat. As expected, food that was consistently mapped onto stopping was indeed more associated with stopping versus going afterwards. In replication of previous results, participants in the no-go condition also showed less desire to eat and reduced food intake relative to the go condition. Together these findings support the idea that food-specific inhibition training prompts the development of automatic inhibition associations, which subsequently facilitate inhibitory control over unwanted food-related urges. Copyright © 2015 Elsevier Ltd. All rights reserved.

Drivers of going concern audit opinions: empirical evidence from Indonesia

Directory of Open Access Journals (Sweden)

Suroto Lina Rahmawati

2017-08-01

Full Text Available The study of the going concern audit opinions is an important component within the enhancement of firms’ responsibility and stewardship. A going concern audit opinions implies that the independent auditor doubt the future of the firm. This study aimed to examine the drivers of the likelihood of the going-concern audit opinions. Previous studies revealed that there were inconsistent drivers influencing the going-concern audit opinion. This study shows similar results to prior works. The result indicates that firms’ financial condition and profitability significantly affect the likelihood of the going-concern audit opinion, while firms’ size and leverage are not the determinants of the intensity of the going concern audit opinion.

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From go-faster stripes to sliding tracksuits

NARCIS (Netherlands)

Tigges, J.

2012-01-01

Today sports and science go increasingly hand in hand. Together with private companies, sporting bodies and other research centres, TU Delft is involved in many innovative sports-related projects, particularly in water sports, where materials can be crucial.

The impacts of a GO-game (Chinese chess intervention on Alzheimer disease in a Northeast Chinese population

Directory of Open Access Journals (Sweden)

Qiao eLin

2015-08-01

Full Text Available A GO game can enhance mental health, but its effects on Alzheimer Disease (AD remains unknown. To address the issue, 147 AD patients were randomly assigned into control (without GO-game intervention, Short-time GO-Game Intervention (SGGI, one hour daily and Long-time GO-game Intervention (LGGI, two hours daily groups. After 6-month follow-up, the game reduced the mean score of Montgomery-Asberg Depression Rating Scales (MADRS of 4.72(95% CI, 0.69 to 9.12 and Hospital Anxiety and Depression Scale (HADS of 1.75 (95% CI, 0.17 to 3.68, and increased the mean score of Global Assessment of Functioning (GAF of 4.95 (95% CI, -1.37 to 9.18 and RAND-36 of 4.61 (95% CI, -2.75 to 11.32 (P < 0.05 via controls. A GO-game intervention improved 9 of 11 items of KICA-dep (Kimberley Indigenous Cognitive Assessment of Depression. Meanwhile, serum levels of brain derived neurotrophic factor (BDNF were higher in SGGI and LGGI groups (24.02 ± 7.16 and 28.88 ± 4.12 ng/ml respectively, P = 0.051 than those in controls (17.28 ± 7.75 ng/ml (P < 0.001. The serum levels of BDNF showed a negative relation with MADRS and a positive relation with RAND-36 (P < 0.01. A GO-game intervention ameliorates AD manifestations by up-regulating BDNF levels.

Physics To Go: an Outreach Digital Library

Science.gov (United States)

Lee, Edward V.

2006-12-01

Physics to Go, part of the NSF-funded ComPADRE digital library, is a collection of websites for informal physics learning. This talk will present Physics To Go’s homepage features, show how these features are created, how resources are identified, and how Physics To Go complements other physics outreach websites.

Hydrophobic cotton textile surfaces using an amphiphilic graphene oxide (GO) coating

International Nuclear Information System (INIS)

Tissera, Nadeeka D.; Wijesena, Ruchira N.; Perera, J. Rangana; Nalin de Silva, K.M.; Amaratunge, Gehan A.J.

2015-01-01

Graphical abstract: - Highlights: • Different GO dispersions were prepared by sonicating different amounts of GO in water. Degree of exfoliation of these GO sheets in water was analyzed using Atomic Force Microscopy (AFM). • AFM results obtained showed higher the GO concentration on water more the size of GO sheets and lesser the degree of exfoliation. • GO with different amounts was deposited on cotton fabric using simple dyeing method. • High GO loading on cotton increase the surface area coverage of the textile fibers with GO sheets. This led to less edge to mid area ratio of grafted GO sheets. • As contribution of mid area of GO increase on fiber surface cotton fabric becomes more hydrophobic. • Amphiphilic property of GO sheets was used to lower the surface energy of the cotton fibers leading to hydrophobic property. - Abstract: We report for the first time hydrophobic properties on cotton fabric successfully achieved by grafting graphene oxide on the fabric surface, using a dyeing method. Graphite oxide synthesized by oxidizing natural flake graphite employing improved Hummer's method showed an inter layer spacing of ∼1 nm from XRD. Synthesized graphite oxide was exfoliated in water using ultrasound energy to obtain graphene oxide (GO). AFM data obtained for the graphene oxide dispersed in an aqueous medium revealed a non-uniform size distribution. FTIR characterization of the synthesized GO sheets showed both hydrophilic and hydrophobic functional groups present on the nano sheets giving them an amphiphilic property. GO flakes of different sizes were successfully grafted on to a cotton fabric surface using a dip dry method. Loading different amounts of graphene oxide on the cotton fiber surface allowed the fabric to demonstrate different degrees of hydrophobicity. The highest observed water contact angle was at 143° with the highest loading of graphene oxide. The fabric surfaces grafted with GO also exhibits adhesive type hydrophobicity

Gene Ontology Terms and Automated Annotation for Energy-Related Microbial Genomes

Energy Technology Data Exchange (ETDEWEB)

Mukhopadhyay, Biswarup [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Tyler, Brett M. [Oregon State Univ., Corvallis, OR (United States); Setubal, Joao [Univ. of Sao Paulo (Brazil); Murali, T. M. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)

2017-11-03

Gene Ontology (GO) is one of the more widely used functional ontologies for describing gene functions at various levels. The project developed 660 GO terms for describing energy-related microbial processes and filled the known gaps in this area of the GO system, and then used these terms to describe functions of 179 genes to showcase the utilities of the new resources. It hosted a series of workshops and made presentations at key meetings to inform and train scientific community members on these terms and to receive inputs from them for the GO term generation efforts. The project has developed a website for storing and displaying the resources (http://www.mengo.biochem.vt.edu/). The outcome of the project was further disseminated through peer-reviewed publications and poster and seminar presentations.

Ti-GO-Ag nanocomposite: the effect of content level on the antimicrobial activity and cytotoxicity

Directory of Open Access Journals (Sweden)

Jin J

2017-06-01

Full Text Available Jianfeng Jin,1,2 Li Zhang,3 Mengqi Shi,3 Yumei Zhang,3 Qintao Wang11State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi’an, 2Department of General Dentistry, Kunming Municipal Stomatology Hospital, Kunming, 3State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Surface modification of titanium (Ti implants are extensively studied in order to obtain prominent biocompatibility and antimicrobial activity, especially preventing implant-associated infection. In this study, Ti substrates surface were modified by graphene oxide (GO thin film and silver (Ag nanoparticles via electroplating and ultraviolet reduction methods so as to achieve this purpose. Microstructures, distribution, quantities and spectral peaks of GO and Ag loading on the Ti sheets surface were characterized. GO-Ag-Ti multiphase nanocomposite exhibited excellent antimicrobial ability and anti-adherence performance. Subsequently, morphology, membrane integrity, apoptosis and relative genes expression of bacteria incubated on the Ti samples surface were monitored to reveal the bactericidal mechanism. Additionally, the cytotoxicity of Ti substrates incorporating GO thin film and Ag nanoparticles were investigated. GO-Ag-Ti composite configuration that have outstanding antibacterial properties will provide the foundation to study bone integration in vitro and in vivo in the future.Keywords: GO-Ag-Ti multiphase nanocomposite, microstructure and quantities, antibacterial activity, bactericidal mechanism, cytotoxicity

Systematically characterizing and prioritizing chemosensitivity related gene based on Gene Ontology and protein interaction network

Directory of Open Access Journals (Sweden)

Chen Xin

2012-10-01

Full Text Available Abstract Background The identification of genes that predict in vitro cellular chemosensitivity of cancer cells is of great importance. Chemosensitivity related genes (CRGs have been widely utilized to guide clinical and cancer chemotherapy decisions. In addition, CRGs potentially share functional characteristics and network features in protein interaction networks (PPIN. Methods In this study, we proposed a method to identify CRGs based on Gene Ontology (GO and PPIN. Firstly, we documented 150 pairs of drug-CCRG (curated chemosensitivity related gene from 492 published papers. Secondly, we characterized CCRGs from the perspective of GO and PPIN. Thirdly, we prioritized CRGs based on CCRGs’ GO and network characteristics. Lastly, we evaluated the performance of the proposed method. Results We found that CCRG enriched GO terms were most often related to chemosensitivity and exhibited higher similarity scores compared to randomly selected genes. Moreover, CCRGs played key roles in maintaining the connectivity and controlling the information flow of PPINs. We then prioritized CRGs using CCRG enriched GO terms and CCRG network characteristics in order to obtain a database of predicted drug-CRGs that included 53 CRGs, 32 of which have been reported to affect susceptibility to drugs. Our proposed method identifies a greater number of drug-CCRGs, and drug-CCRGs are much more significantly enriched in predicted drug-CRGs, compared to a method based on the correlation of gene expression and drug activity. The mean area under ROC curve (AUC for our method is 65.2%, whereas that for the traditional method is 55.2%. Conclusions Our method not only identifies CRGs with expression patterns strongly correlated with drug activity, but also identifies CRGs in which expression is weakly correlated with drug activity. This study provides the framework for the identification of signatures that predict in vitro cellular chemosensitivity and offers a valuable

Raman Spectra of Luminescent Graphene Oxide (GO-Phosphor Hybrid Nanoscrolls

Directory of Open Access Journals (Sweden)

Janardhanan. R. Rani

2015-12-01

Full Text Available Graphene oxide (GO-phosphor hybrid nanoscrolls were synthesized using a simple chemical method. The GO-phosphor ratio was varied to find the optimum ratio for enhanced optical characteristics of the hybrid. A scanning electron microscope analysis revealed that synthesized GO scrolls achieved a length of over 20 μm with interior cavities. The GO-phosphor hybrid is extensively analyzed using Raman spectroscopy, suggesting that various Raman combination modes are activated with the appearance of a low-frequency radial breathing-like mode (RBLM of the type observed in carbon nanotubes. All of the synthesized GO-phosphor hybrids exhibit an intense luminescent emission around 540 nm along with a broad emission at approximately 400 nm, with the intensity ratio varying with the GO-phosphor ratio. The photoluminescence emissions were gauged using Commission Internationale d'Eclairage (CIE coordinates and at an optimum ratio. The coordinates shift to the white region of the color spectra. Our study suggests that the GO-phosphor hybrid nanoscrolls are suitable candidates for light-emitting applications.

Multifunctional devices based on SnO2@rGO-coated fibers for human motion monitoring, ethanol detection, and photo response

Science.gov (United States)

Mi, Qing; Wang, Qi; Zang, Siyao; Chai, Zhaoer; Zhang, Jinnan; Ren, Xiaomin

2018-05-01

In this study, we developed a multifunctional device based on SnO2@rGO-coated fibers utilizing plasma treatment, dip coating, and microwave irradiation in sequence, and finally realized highly sensitive human motion monitoring, relatively good ethanol detection, and an obvious photo response. Moreover, the high level of comfort and compactness derived from highly elastic and comfortable fabrics contributes to the long-term availability and test accuracy. As an attempt at multifunctional integration of smart clothing, this work provides an attractive and relatively practical research direction.

To Go or Not to Go: A Proof of Concept Study Testing Food-Specific Inhibition Training for Women with Eating and Weight Disorders.

Science.gov (United States)

Turton, Robert; Nazar, Bruno P; Burgess, Emilee E; Lawrence, Natalia S; Cardi, Valentina; Treasure, Janet; Hirsch, Colette R

2018-01-01

Inefficient food-specific inhibitory control is a potential mechanism that underlies binge eating in bulimia nervosa and binge eating disorder. Go/no-go training tools have been developed to increase inhibitory control over eating impulses. Using a within-subjects design, this study examined whether one session of food-specific go/no-go training, versus general inhibitory control training, modifies eating behaviour. The primary outcome measure was food consumption on a taste test following each training session. Women with bulimia nervosa and binge eating disorder had small non-significant reductions in high-calorie food consumption on the taste test following the food-specific compared with the general training. There were no effects on eating disorder symptomatic behaviour (i.e. binge eating/purging) in the 24 h post-training. The training task was found to be acceptable by the clinical groups. More research is needed with larger sample sizes to determine the effectiveness of this training approach for clinical populations. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

GO evaluation of a PWR spray system. Final report

International Nuclear Information System (INIS)

Long, W.T.

1975-08-01

GO is a reliability analysis methodology developed over the years from 1960 to the present by Kaman Sciences Corporation, Colorado Springs, Colorado. In this report the GO methodology is presented and its application demonstrated by performing a reliability analysis of a conceptual PWR Containment Spray System. Certain numerical results obtained are compared with those of a prior fault tree analysis of the same system as documented in the 11 January 1973 draft report, A Fault Tree Evaluation of a PWR Spray System

THE GOING CONCERN - THEORY AND PRACTICE IN THE FINANCIAL AUDIT

Directory of Open Access Journals (Sweden)

Tara Ioan Gheorghe

2011-12-01

Full Text Available The financial audit is called in to take the responsibilities on prevention of shocking events in the life of a company. Therefore we have to look into both of some concepts and the practice of financial audit so as to improve its performance and utility. On this purpose we assume some proposals to going concern concept and its practically use improvement. Thus, taking in account the actual statements of the IFAC documents (ISA 570 and the latest results on 'going concern research (A. Rosman 2011, Bihmani and Co. 2009, Geiger, Raghunandan and Rama 2005, N. Kuruppu and Co. 2002 we consider something more might be done to accurately clarify the concept and to meet the investors requirements regarding financial auditors responsibilities on the future of the audited companies. We are going to focus on subjects such as: which are the responsibilities of the financial audit and the management regarding the going concern, what kind of audit should be performed on the matter of a company future, which are the best methods to analyze the future going of a company, where the information should comes from and how compulsory a mission of audit on 'going concern' should be. Using a sample of a couple of listed companies filing for bankruptcy we reached a conclusion regarding the connection between going concern opinion and its real effects. The conclusion consists in the fact that there is not a compulsory connection between the going concern opinion and the decision for bankruptcy. On this basis and, as a result of studying the conclusions of the upper named authors, we assume the idea that a separate going concern audit mission should be conceived, organized and performed. In this sense the concept of going concept, itself, should be improved. In our opinion a new concept of going concern would have better practical results regarding both methodology of performing the assessment of an entity as going concern and the responsibility of financial auditors in

Rethinking The Going Concern Assumption As A Pre-Condition For Accounting Measurement

OpenAIRE

Saratiel Wedzerai Musvoto; Daan G Gouws

2011-01-01

This study compares the principles of the going concern concept against the principles of representational measurement to determine if it is possible to establish foundations of accounting measurement with the going concern concept as a precondition. Representational measurement theory is a theory that establishes measurement in social scientific disciplines such as accounting. The going concern assumption is prescribed as one of the preconditions for measuring the attributes of the elements ...

A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related

Directory of Open Access Journals (Sweden)

Vasieva Olga

2011-01-01

Full Text Available Abstract Background The ageing of the worldwide population means there is a growing need for research on the biology of ageing. DNA damage is likely a key contributor to the ageing process and elucidating the role of different DNA repair systems in ageing is of great interest. In this paper we propose a data mining approach, based on classification methods (decision trees and Naive Bayes, for analysing data about human DNA repair genes. The goal is to build classification models that allow us to discriminate between ageing-related and non-ageing-related DNA repair genes, in order to better understand their different properties. Results The main patterns discovered by the classification methods are as follows: (a the number of protein-protein interactions was a predictor of DNA repair proteins being ageing-related; (b the use of predictor attributes based on protein-protein interactions considerably increased predictive accuracy of attributes based on Gene Ontology (GO annotations; (c GO terms related to "response to stimulus" seem reasonably good predictors of ageing-relatedness for DNA repair genes; (d interaction with the XRCC5 (Ku80 protein is a strong predictor of ageing-relatedness for DNA repair genes; and (e DNA repair genes with a high expression in T lymphocytes are more likely to be ageing-related. Conclusions The above patterns are broadly integrated in an analysis discussing relations between Ku, the non-homologous end joining DNA repair pathway, ageing and lymphocyte development. These patterns and their analysis support non-homologous end joining double strand break repair as central to the ageing-relatedness of DNA repair genes. Our work also showcases the use of protein interaction partners to improve accuracy in data mining methods and our approach could be applied to other ageing-related pathways.

The media go-along

DEFF Research Database (Denmark)

Jørgensen, Kristian Møller

2016-01-01

This article contributes methodologically and theoretically to Christine Hine’s call for a mobilities oriented internet ethnography. First, a ‘media go-along’, combining interviews and observations of a personal communication service at hand, is developed. Research participants give verbal and vi...

Going Corporate

CERN Document Server

Kadre, Shailendra

2011-01-01

Going Corporate: A Geek's Guide shows technology workers how to gain the understanding and skills necessary for becoming an effective, promotable manager or sought-after consultant or freelancer. Technology professionals typically dive deeply into small pieces of technology - like lines of code or the design of a circuit. As a result, they may have trouble seeing the bigger picture and how their work supports an organization's goals. But ignoring or dismissing the business or operational aspects of projects and products can lead to career stagnation. In fact, understanding the larger business

DeepGO: predicting protein functions from sequence and interactions using a deep ontology-aware classifier

KAUST Repository

Kulmanov, Maxat

2017-09-27

Motivation A large number of protein sequences are becoming available through the application of novel high-throughput sequencing technologies. Experimental functional characterization of these proteins is time-consuming and expensive, and is often only done rigorously for few selected model organisms. Computational function prediction approaches have been suggested to fill this gap. The functions of proteins are classified using the Gene Ontology (GO), which contains over 40 000 classes. Additionally, proteins have multiple functions, making function prediction a large-scale, multi-class, multi-label problem. Results We have developed a novel method to predict protein function from sequence. We use deep learning to learn features from protein sequences as well as a cross-species protein–protein interaction network. Our approach specifically outputs information in the structure of the GO and utilizes the dependencies between GO classes as background information to construct a deep learning model. We evaluate our method using the standards established by the Computational Assessment of Function Annotation (CAFA) and demonstrate a significant improvement over baseline methods such as BLAST, in particular for predicting cellular locations.

Surgical video recording with a modified GoPro Hero 4 camera

Directory of Open Access Journals (Sweden)

Lin LK

2016-01-01

Full Text Available Lily Koo Lin Department of Ophthalmology and Vision Science, University of California, Davis Eye Center, Sacramento, CA, USA Background: Surgical videography can provide analytical self-examination for the surgeon, teaching opportunities for trainees, and allow for surgical case presentations. This study examined if a modified GoPro Hero 4 camera with a 25 mm lens could prove to be a cost-effective method of surgical videography with enough detail for oculoplastic and strabismus surgery. Method: The stock lens mount and lens were removed from a GoPro Hero 4 camera, and was refitted with a Peau Productions SuperMount and 25 mm lens. The modified GoPro Hero 4 camera was then fixed to an overhead surgical light. Results: Camera settings were set to 1080p video resolution. The 25 mm lens allowed for nine times the magnification as the GoPro stock lens. There was no noticeable video distortion. The entire cost was less than 600 USD. Conclusion: The adapted GoPro Hero 4 with a 25 mm lens allows for high-definition, cost-effective, portable video capture of oculoplastic and strabismus surgery. The 25 mm lens allows for detailed videography that can enhance surgical teaching and self-examination. Keywords: teaching, oculoplastic, strabismus

The game of go as a complex network

Science.gov (United States)

Georgeot, Bertrand; Giraud, Olivier; Kandiah, Vivek

2014-03-01

We have studied the game of go, one of the most ancient and complex board games, from a complex network perspective. We have defined a proper categorization of moves taking into account the local environment, and shown that in this case Zipf's law emerges from data taken from real games. The network shows differences between professional and amateur games, different level of amateurs, or different phases of the game. Certain eigenvectors are localized on specific groups of moves which correspond to different strategies (communities of moves). The point of view developed should allow to better modelize such games and could also help to design simulators which could in the future beat good human players. Our approach could be used for other types of games, and in parallel shed light on the human decision making process.

AGATE: Autonomous Go and Touch Exploration, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The innovation (AGATE, for Autonomous Go And Touch Exploration) will enable single-sol "go and touch" instrument placement from distances of up to five meters for...

Go4Life

Medline Plus

Full Text Available ... Duration: 117 seconds. National Institute On Aging 6 years ago 12,952 views Trainer Sandy shows Linda how to do lower body exercises in her office with Go4Life's Toe Stand. CC ... Exercise--Overhead Arm Raise - Duration: 88 seconds. National Institute On Aging 6 years ago 9,529 views Trainer Sandy shows Carol ...

GO methodology. Volume 1. Overview manual

International Nuclear Information System (INIS)

1983-06-01

The GO methodology is a success-oriented probabilistic system performance analysis technique. The methodology can be used to quantify system reliability and availability, identify and rank critical components and the contributors to system failure, construct event trees, and perform statistical uncertainty analysis. Additional capabilities of the method currently under development will enhance its use in evaluating the effects of external events and common cause failures on system performance. This Overview Manual provides a description of the GO Methodology, how it can be used, and benefits of using it in the analysis of complex systems

An immediate go-ahead for nuclear plants

International Nuclear Information System (INIS)

Stubbe, C.

1986-01-01

In the meantime a wealth of court decisions have been reached regarding an immediate go-ahead for nuclear power plants. For all that, it is still not clear - and varying decisions have been made in judgement - according to which criteria the judicial balance is to be made between the interests of the plaintiff in bringing about a stay of the proceedings and the interests of the planner in going ahead with them. The author advocates an examination of the main issue already during suspension proceedings until the court can form a preliminary opinion on the chances of success of the main issue. He also advocates in the Administrative Court Ordinance regulations regarding go-ahead as determined in the commission draft to the Administrative Court of 1978. (orig.) [de

An Emotional Go/No-Go fMRI study in adolescents with depressive symptoms following concussion.

Science.gov (United States)

Ho, Rachelle A; Hall, Geoffrey B; Noseworthy, Michael D; DeMatteo, Carol

2017-10-03

Following concussion, adolescents may experience both poor inhibitory control and increased depressive symptoms. fMRI research suggests that adolescents with major depressive disorder have abnormal physiological responses in the frontostriatal pathway, and exhibit poorer inhibitory control in the presence of negatively-aroused images. The scarcity of information surrounding depression following concussion in adolescents makes it difficult to identify patients at risk of depression after injury. This is the first study to examine neural activity patterns in adolescents with post-concussive depressive symptoms. To explore the effect of depressive symptoms on inhibitory control in adolescents with concussion in the presence of emotional stimuli using fMRI. Using a prospective cohort design, 30 adolescents diagnosed with concussion between 10 and 17years were recruited. The Children's Depression Inventory questionnaire was used to divide participants into two groups: average or elevated levels of depressive symptoms. Participants completed an Emotional Go/No-Go task involving angry or neutral faces in a 3Telsa MRI scanner. Eleven participants had elevated depressive symptoms, of which 72% were hit in the occipital region of the head at the time of injury. fMRI results from the Emotional Go/No-Go task revealed activity patterns in the overall sample. Faces activated regions associated with both facial and cognitive processing. However, frontal regions that are usually associated with inhibitory control were not activated. Adolescents with elevated levels of depressive symptoms engaged more frontal lobe regions during the task than the average group. They also showed a trend towards worse symptoms following MRI scanning. Adolescents with elevated depressive symptoms engaged brain regions subserving evaluative processing of social interactions. This finding provides insight into the role the environment plays in contributing to the cognitive demands placed on adolescents

Going beyond representational anthropology

DEFF Research Database (Denmark)

Winther, Ida Wentzel

Going beyond representational anthropology: Re-presenting bodily, emotional and virtual practices in everyday life. Separated youngsters and families in Greenland Greenland is a huge island, with a total of four high-schools. Many youngsters (age 16-18) move far away from home in order to get...

Effect of Graphene Oxide (GO) on the Surface Morphology & Hydrophilicity of Polyethersulfone (PES)

Science.gov (United States)

Junaidi, N. F. D.; Khalil, N. A.; Jahari, A. F.; Shaari, N. Z. K.; Shahruddin, M. Z.; Alias, N. H.; Othman, N. H.

2018-05-01

Membrane has been widely used in water and wastewater treatment. One of the major issues related membrane separation is concentration polarization or fouling, which can lead to a decline of flux and premature failure of membrane. However, fouling can be controlled by modification of membrane properties such as morphology and hydrophilicity. In this work, a modification of polymeric membrane, polyethersulfone (PES) was carried out using graphene oxide in order to attain high antifouling characteristics. Graphene oxide (GO) was added at different compositions ranging from (0.1 wt%-1.0 wt%). GO was synthesized using modified Hummers’ method and characterized using XRD and FTIR prior to using it as additive for the PES membrane. The prepared PES-GO composite membranes were characterized using FTIR and SEM, Contact angle measurement and pure water flux test were then conducted to investigate the hydrophilicity of the PES-GO membranes. It was found that the additions of GO has significantly improved the hydrophilicity of the membranes.

Pre-exposure prophylaxis of HIV: A right way to go or a long way to go?

Science.gov (United States)

Yu, Wenya; Wang, Lu; Han, Na; Zhang, Xiayan; Mahapatra, Tanmay; Mahapatra, Sanchita; Babu, Giridhara R.; Tang, Weiming; Detels, Roger; Zhao, Jinkou

2014-01-01

Antiretroviral drugs are being tried as candidates for the pre-exposure prophylaxis (PrEP) against HIV for a considerable period, due to their potential for immediate inhibition of viral replication. Discrepancies in the findings called for a critical review of the relevant efforts and their outcomes. A systematic literature search identified 143 eligible articles of which only 5 reported complete findings while another 11 were still on-going. Observed moderate efficacy and good safety profile seemed to identify PrEP as a promising step for minimizing the spread of HIV to relatively unaffected population and controlling the epidemic among high risk population groups. But the duration of this efficacy was found to depend heavily on the availability, adherence and other related issues like cost, political commitment, ethical consideration etc. To prevent potential cultural and behavioral modifications, proper pre-administration counseling also seemed critical for the success of PrEP as a cost-effective intervention with adequate coverage. PMID:25078629

Theranostic GO-based nanohybrid for tumor induced imaging and potential combinational tumor therapy.

Science.gov (United States)

Qin, Si-Yong; Feng, Jun; Rong, Lei; Jia, Hui-Zhen; Chen, Si; Liu, Xiang-Ji; Luo, Guo-Feng; Zhuo, Ren-Xi; Zhang, Xian-Zheng

2014-02-12

Graphene oxide (GO)-based theranostic nanohybrid is designed for tumor induced imaging and potential combinational tumor therapy. The anti-tumor drug, Doxorubicin (DOX) is chemically conjugated to the poly(ethylenimine)-co-poly(ethylene glycol) (PEI-PEG) grafted GO via a MMP2-cleavable PLGLAG peptide linkage. The therapeutic efficacy of DOX is chemically locked and its intrinsic fluorescence is quenched by GO under normal physiological condition. Once stimulated by the MMP2 enzyme over-expressed in tumor tissues, the resulting peptide cleavage permits the unloading of DOX for tumor therapy and concurrent fluorescence recovery of DOX for in situ tumor cell imaging. Attractively, this PEI-bearing nanohybrid can mediate efficient DNA transfection and shows great potential for combinational drug/gene therapy. This tumor induced imaging and potential combinational therapy will open a window for tumor treatment by offering a unique theranostic approach through merging the diagnostic capability and pathology-responsive therapeutic function. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Talar Fractures in Children: A Possible Injury After Go-Karting Accidents.

Science.gov (United States)

Kamphuis, Saskia J M; Meijs, Claartje M E M; Kleinveld, Sanne; Diekerhof, Carel H; van der Heijden, Frank H W M

2015-01-01

Go-karting is an increasingly popular high-energy sport enjoyed by both children and adults. Because of the speeds involved, accidents involving go-karts can lead to serious injury. We describe 6 talar fractures in 4 patients that resulted from go-karting accidents. Talar fractures can cause severe damage to the tibiotalar joint, talocalcaneal or subtalar joint, and the talonavicular joint. This damage can, in turn, lead to complications such as avascular necrosis, arthritis, nonunion, delayed union, and neuropraxia, which have the potential to cause long-term disability in a child. Copyright © 2015 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

Houston Community College (HCC)-Mobile Go Center Program

Science.gov (United States)

Ramirez, Daniel; Sterling, Cheryl; Grays, Shantay R.

2010-01-01

The Houston Community College Mobile Go Center brings college enrollment assistance to the doorstep of our community. It operates in a variety of settings, offering college-going material and person-to-person assistance at numerous city events. Services include assistance with academic advising, completing the FAFSA, college application process,…

Going Solar Yields Long-Term Economical, Educational Benefits

Science.gov (United States)

von Moos, Brian

2009-01-01

Going solar is not an easy decision, but a long-term investment with a potentially substantial up-front cost. While some schools have enough capital in reserve, can raise bond money, or can solicit sufficient donations, many schools rely on creative financial programs to make a solar energy system economically feasible. Thinking about going solar…

GoSam. A program for automated one-loop calculations

Energy Technology Data Exchange (ETDEWEB)

Cullen, G. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Greiner, N.; Heinrich, G.; Reiter, T. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Luisoni, G. [Durham Univ. (United Kingdom). Inst. for Particle Physics Phenomenology; Mastrolia, P. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Padua Univ. (Italy). Dipt. di Fisica; Ossola, G. [City Univ. of New York, NY (United States). New York City College of Technology; Tramontano, F. [European Organization for Nuclear Research (CERN), Geneva (Switzerland)

2011-11-15

The program package GoSam is presented which aims at the automated calculation of one-loop amplitudes for multi-particle processes. The amplitudes are generated in terms of Feynman diagrams and can be reduced using either D-dimensional integrand-level decomposition or tensor reduction, or a combination of both. GoSam can be used to calculate one-loop corrections to both QCD and electroweak theory, and model files for theories Beyond the Standard Model can be linked as well. A standard interface to programs calculating real radiation is also included. The flexibility of the program is demonstrated by various examples. (orig.)

GoSam. A program for automated one-loop calculations

International Nuclear Information System (INIS)

Cullen, G.; Greiner, N.; Heinrich, G.; Reiter, T.; Luisoni, G.

2011-11-01

The program package GoSam is presented which aims at the automated calculation of one-loop amplitudes for multi-particle processes. The amplitudes are generated in terms of Feynman diagrams and can be reduced using either D-dimensional integrand-level decomposition or tensor reduction, or a combination of both. GoSam can be used to calculate one-loop corrections to both QCD and electroweak theory, and model files for theories Beyond the Standard Model can be linked as well. A standard interface to programs calculating real radiation is also included. The flexibility of the program is demonstrated by various examples. (orig.)

GoSam: A program for automated one-loop calculations

International Nuclear Information System (INIS)

Cullen, G; Greiner, N; Heinrich, G; Mastrolia, P; Reiter, T; Luisoni, G; Ossola, G; Tramontano, F

2012-01-01

The program package GoSam is presented which aims at the automated calculation of one-loop amplitudes for multi-particle processes. The amplitudes are generated in terms of Feynman diagrams and can be reduced using either D-dimensional integrand-level decomposition or tensor reduction, or a combination of both. GoSam can be used to calculate one-loop corrections to both QCD and electroweak theory, and model files for theories Beyond the Standard Model can be linked as well. A standard interface to programs calculating real radiation is also included. The flexibility of the program is demonstrated by various examples.

What does Pokémon Go teach us about geography?

Directory of Open Access Journals (Sweden)

H. Gong

2017-06-01

Full Text Available Pokémon Go, a highly popular, recently launched augmented-reality-based video game, fosters players' interaction with the real world. In this commentary we elaborate on how location-based games, such as Pokémon Go, have provided insights into the perception and understanding of space, as well as into their impact on patterns of mobility. In addition to that, we compare Pokémon Go with geocaching, another location-based game, to further elaborate on what Pokémon Go fails to do in terms of the practices of geographical exploration.

No-go theorems for the minimization of potentials

International Nuclear Information System (INIS)

Chang, D.; Kumar, A.

1985-01-01

Using a theorem in linear algebra, we prove some no-go theorems in the minimization of potentials related to the problem of symmetry breaking. Some applications in the grand unified model building are mentioned. Another application of the algebraic theorem is also included to demonstrate its usefulness

Rhodamine B removal on A-rGO/cobalt oxide nanoparticles composite by adsorption from contaminated water

Science.gov (United States)

Alwan, Salam H.; Alshamsi, Hassan A. Habeeb; Jasim, Layth S.

2018-06-01

Cobalt oxide nanoparticles@rGO composite is prepared by using graphene oxide (GO) as a supporting substance. GO is first treated with ascorbic acid to form rGO. Finally, cobalt oxide nanoparticles reaction with rGO sheets and using as the adsorbent to removal Rh.B dye from wastewater. The morphology and chemical structure of prepared samples were characterized by FTIR, X-ray spectroscopy, SEM-EDX, TEM, AFM and TGA. The adsorption of Rh.B dye on the A-rGO/Co3O4 composite was accomplished under different conditions that are equilibrium time, pH solution, ionic strength, and temperature. The adsorption isotherms of Rh.B dye on the A-rGO/Co3O4 composite could be illustrated well by the Langmuir, Freundlich and Tempkin model. The thermodynamic factors (ΔHo, ΔSo, and ΔGo) estimated from the temperature-dependent isotherms revealed that the adsorption reaction of Rh.B dye on the A-rGO/Co3O4 composite was an endothermic and spontaneous process.

Going to the Hospital

Science.gov (United States)

... and therapists will show you how to use pieces of equipment, like crutches, if you need them. Some hospitals have child life specialists. Their job is to make sure kids in the hospital understand what's going on around them and help them feel more ...

GoNorth! - An Adventure Learning Case Study

Science.gov (United States)

Porsild, M.; Doering, A.; Pregont, P.

2008-12-01

GoNorth! is an adventure learning series developed at the University of Minnesota in collaboration with NOMADS Online Expeditions. GoNorth! uses real-time experiences of dogsled expeditions on a multimedia saturated website at http://www.PolarHusky.com to motivate and engage millions of K-12 students and teachers. The program is free and research (Doering & Veletsianos, 2007) shows that it can be adopted by any teacher who signs up to use the program. It is currently utilized in 3400+ classrooms across the 50 US States and in 29 countries worldwide. Research (Doering & Veletsianos, 2007; 2008) notes that students working with GoNorth! are excited, motivated, and eager to engage with authentic tasks, solve real-world problems, collaborate with colleagues and experts, and initiate actions in their own community. Our team of educators, scientists and explorers circumnavigate the Arctic traveling by dog team to a new Arctic locale every year. Driven by an environmental question of particular relevance to the given Arctic region, each year a comprehensive natural and social science GoNorth! Curriculum & Activity Guide (450+ pages) is developed reflecting the expedition's current Arctic locale and its indigenous culture. The associated online learning environment delivers comprehensive resources about the region of travel, collaborative opportunities, live field updates and field research findings synched real-time to the curriculum. Field research relevant to understanding patterns of climate change and polar science is conducted with independent researchers featured as "Cool GoNorth! Scientists." Collaborations span from scientists at NASA and the United States Department of Agriculture to student observers in pan-Arctic communities as part of the NSF-supported initiative "What Is Climate Change to You?." This scientific research and fieldwork in turn coincides with the curriculum. The result is a community of learners on the Internet gaining knowledge from Arctic

The Iron Dog: The Care and Keeping of a Sno-go.

Science.gov (United States)

Keller, Rosanne

Part of a series of home literacy readers with conversational text and sketches, this booklet addresses the Alaskan environment, where the snowmobile or sno-go has recently replaced the dogsled and mechanized land travel. Only with safe drivers is this "Iron Dog" one of man's best friends. The good sno-go driver stays off roads, plane…

pLoc-mHum: predict subcellular localization of multi-location human proteins via general PseAAC to winnow out the crucial GO information.

Science.gov (United States)

Cheng, Xiang; Xiao, Xuan; Chou, Kuo-Chen

2018-05-01

For in-depth understanding the functions of proteins in a cell, the knowledge of their subcellular localization is indispensable. The current study is focused on human protein subcellular location prediction based on the sequence information alone. Although considerable efforts have been made in this regard, the problem is far from being solved yet. Most existing methods can be used to deal with single-location proteins only. Actually, proteins with multi-locations may have some special biological functions that are particularly important for both basic research and drug design. Using the multi-label theory, we present a new predictor called 'pLoc-mHum' by extracting the crucial GO (Gene Ontology) information into the general PseAAC (Pseudo Amino Acid Composition). Rigorous cross-validations on a same stringent benchmark dataset have indicated that the proposed pLoc-mHum predictor is remarkably superior to iLoc-Hum, the state-of-the-art method in predicting the human protein subcellular localization. To maximize the convenience of most experimental scientists, a user-friendly web-server for the new predictor has been established at http://www.jci-bioinfo.cn/pLoc-mHum/, by which users can easily get their desired results without the need to go through the complicated mathematics involved. xcheng@gordonlifescience.org. Supplementary data are available at Bioinformatics online.

Cross-species comparison of biological themes and underlying genes on a global gene expression scale in a mouse model of colorectal liver metastasis and in clinical specimens

Directory of Open Access Journals (Sweden)

Schirmacher Peter

2008-09-01

Full Text Available Abstract Background Invasion-related genes over-expressed by tumor cells as well as by reacting host cells represent promising drug targets for anti-cancer therapy. Such candidate genes need to be validated in appropriate animal models. Results This study examined the suitability of a murine model (CT26/Balb/C of colorectal liver metastasis to represent clinical liver metastasis specimens using a global gene expression approach. Cross-species similarity was examined between pure liver, liver invasion, tumor invasion and pure tumor compartments through overlap of up-regulated genes and gene ontology (GO-based biological themes on the level of single GO-terms and of condensed GO-term families. Three out of four GO-term families were conserved in a compartment-specific way between the species: secondary metabolism (liver, invasion (invasion front, and immune response (invasion front and liver. Among the individual GO-terms over-represented in the invasion compartments in both species were "extracellular matrix", "cell motility", "cell adhesion" and "antigen presentation" indicating that typical invasion related processes are operating in both species. This was reflected on the single gene level as well, as cross-species overlap of potential target genes over-expressed in the combined invasion front compartments reached up to 36.5%. Generally, histopathology and gene expression correlated well as the highest single gene overlap was found to be 44% in syn-compartmental comparisons (liver versus liver whereas cross-compartmental overlaps were much lower (e.g. liver versus tumor: 9.7%. However, single gene overlap was surprisingly high in some cross-compartmental comparisons (e.g. human liver invasion compartment and murine tumor invasion compartment: 9.0% despite little histolopathologic similarity indicating that invasion relevant genes are not necessarily confined to histologically defined compartments. Conclusion In summary, cross

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)

DEFF Research Database (Denmark)

Hansen, Rie Schultz; Diness, Thomas Goldin; Christ, Torsten

2005-01-01

The cardiac action potential is generated by a concerted action of different ion channels and transporters. Dysfunction of any of these membrane proteins can give rise to cardiac arrhythmias, which is particularly true for the repolarizing potassium channels. We suggest that an increased repolari......The cardiac action potential is generated by a concerted action of different ion channels and transporters. Dysfunction of any of these membrane proteins can give rise to cardiac arrhythmias, which is particularly true for the repolarizing potassium channels. We suggest that an increased......M. Application of NS1643 also resulted in a prolonged postrepolarization refractory time. Finally, cardiomyocytes exposed to NS1643 resisted reactivation by small depolarizing currents mimicking early afterdepolarizations. In conclusion, HERG channel activation by small molecules such as NS1643 increases...

The new requirements relating to going concern evaluation and disclosure provide a critical improvement to the financial statements taken as a whole

Directory of Open Access Journals (Sweden)

Achraf A. Seyam

2016-03-01

Full Text Available The going concern principle assumes that an entity will continue to exist into the future. This assumption implies that the entity will not be compelled to end their operations, liquidate their assets, or go into bankruptcy. It is an integral assumption in financial statements since it allows for the deferral of recognition of certain expenses until a period of time into the future, when the company is still assumed to exist. Members of management, as well as financial statement auditors, are required to identify signs that could indicate that an entity will not be able to continue their operations into the near future. Some of these signs include a trend of operating losses, loan defaults, legal proceedings against the entity and so forth. The Financial Accounting Standards Board (FASB updated the going concern guidelines so that issuers of financial statements are uniform in frequency and substance of going concern determination. Prior to the Accounting Standards Update, U.S. GAAP lacked sufficient guidance about management’s responsibility to evaluate whether there is substantial doubt of the entity’s ability to continue as going concern. In order to clarify the uncertainty, FASB issued a new financial reporting standard. This new reporting will be in effect for the annual period ending after December 15, 2016. The updated standard will require management to perform annual and interim assessments of an entity’s ability to continue as a going concern for one year from the date of financial statements issuance.

Varkenstoilet lijkt goed haalbaar

NARCIS (Netherlands)

Weeghel, van H.J.E.; Eijk, van O.N.M.

2011-01-01

Met een varkenstoilet kan de ammoniakemissie bij de bron worden aangepakt. Bovendien biedt het mogelijkheden om mineralen in mest en urine optimaal te herbergen. Voor de ontwikkeling van een goed werkend varkenstoilet zul je inzicht moeten hebben in het poep- en piesgedrag van varkens. Uit een

The going concern principle of entities in accounting regulations

Directory of Open Access Journals (Sweden)

Andrzej Tokarski

2012-12-01

Going concern is defined in both national and international accounting regulations, with no difference between the principle of going concern in the Polish law on accounting and international solutions.

Evidence for the Modulation of Sub-Lexical Processing in Go No-Go Naming: The Elimination of the Frequency x Regularity Interaction

Science.gov (United States)

Cummine, Jacqueline; Amyotte, Josee; Pancheshen, Brent; Chouinard, Brea

2011-01-01

The Frequency (high vs. low) x Regularity (regular vs. exception) interaction found on naming response times is often taken as evidence for parallel processing of sub-lexical and lexical systems. Using a Go/No-go naming task, we investigated the effect of nonword versus pseudohomophone foils on sub-lexical processing and the subsequent Frequency x…

ADHD and cannabis use in young adults examined using fMRI of a Go/NoGo task.

Science.gov (United States)

Rasmussen, Jerod; Casey, B J; van Erp, Theo G M; Tamm, Leanne; Epstein, Jeffery N; Buss, Claudia; Bjork, James M; Molina, Brooke S G; Velanova, Katerina; Mathalon, Daniel H; Somerville, Leah; Swanson, James M; Wigal, Tim; Arnold, L Eugene; Potkin, Steven G

2016-09-01

Children diagnosed with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for substance abuse. Response inhibition is a hallmark of ADHD, yet the combined effects of ADHD and regular substance use on neural networks associated with response inhibition are unknown. Task-based functional Magnetic Resonance Imaging (fMRI) data from young adults with childhood ADHD with (n = 25) and without (n = 25) cannabis use ≥ monthly in the past year were compared with a local normative comparison group (LNCG) with (n = 11) and without (n = 12) cannabis use. Go/NoGo behavioral and fMRI data were evaluated for main and interaction effects of ADHD diagnosis and cannabis use. ADHD participants made significantly more commission errors on NoGo trials than controls. ADHD participants also had less frontoparietal and frontostriatal activity, independent of cannabis use. No main effects of cannabis use on response inhibition or functional brain activation were observed. An interaction of ADHD diagnosis and cannabis use was found in the right hippocampus and cerebellar vermis, with increased recruitment of these regions in cannabis-using controls during correct response inhibition. ADHD participants had impaired response inhibition combined with less fronto-parietal/striatal activity, regardless of cannabis use history. Cannabis use did not impact behavioral response inhibition. Cannabis use was associated with hippocampal and cerebellar activation, areas rich in cannabinoid receptors, in LNCG but not ADHD participants. This may reflect recruitment of compensatory circuitry in cannabis using controls but not ADHD participants. Future studies targeting hippocampal and cerebellar-dependent function in these groups may provide further insight into how this circuitry is altered by ADHD and cannabis use.

Pendekatan Employee Relations Oleh Public Relations (Pr) PT. Indah Kiat Pulp and Paper Tbk Dalam Mensosialisasikan Program Go Green Pada Internal Perusahaan

OpenAIRE

", NURJANAH; Irsyad, Muhammad

2015-01-01

Go Green and Global Warming are two word expression often heard in the last several years. Global warming is the effect which is caused by the inability of the atmosphere in accomodating various kinds of gases thrown up by the earth. Because of that, a company has a responsibility taking care of environment through socializing plantings or it is wellknown as Go Green. One of the company concerns about the environment is through the activity of Go Green campaign. In doing socialization, PR Ind...

Superior antibacterial activity of GlcN-AuNP-GO by ultraviolet irradiation

Energy Technology Data Exchange (ETDEWEB)

Govindaraju, Saravanan; Samal, Monica; Yun, Kyusik, E-mail: ykyusik@gachon.ac.kr

2016-12-01

A complete bacterialysis analysis of glucosamine-gold nanoparticle-graphene oxide (GlcN-AuNP-GO) and UV-irradiated GlcN-AuNP-GO was conducted. Analytical characterization of GlcN-AuNPs, GO and GlcN-AuNP-GO revealed UV-Vis absorbance peak at around 230 and 500 nm. Microscopic characterization of prepared nanomaterials was performed by scanning electron microscope, atomic force microscopy, and high-resolution transmission microscopy. The results confirmed that the GlcN-AuNPs were uniformly decorated on the surface and edges of graphene sheets. In addition, potent antibacterial activity of GlcN-AuNP-GO that was UV irradiated for 10 min and normal GlcN-AuNP-GO was detected, compared to the standard drug kanamycin, against both Gram-negative and positive bacteria. The minimum inhibitory concentration (MIC) and fluorescence intensity spectra results for Escherichia coli and Enterococcus faecalis showed that the UV-irradiated GlcN-AuNP-GO has better antibacterial activity than normal GlcN-AuNP-GO and kanamycin. Morphological changes were detected by AFM after treatment. These results confirmed that GlcN-AuNP-GO is a potent antibacterial agent with good potential for use in manufacturing medical instruments, pharmaceutical industries and in waste water treatment. - Highlights: • Glucosamine-gold nanoaprticle-graphene oxide (GlcN-AuNPs-GO) was synthesized. • Analytical and morphological characterizations were revealed. • UV irradiated GlcN-AuNP-GO has provide better antibacterial activity. • Morphological changes of before and after treating bacterial strains were imaged.

The Auditor's Going-Concern Opinion Decision

OpenAIRE

Tae G. Ryu; Chul-Young Roh

2007-01-01

In this study, we expand on several previous studies related to the materiality judgments and the auditor's propensity to issue a going-concern opinion to financially troubled but non-bankrupt companies. We test the auditor's materiality thresholds by investigating whether there is any significant difference in accuracy among audit firms, especially between Big Six (Five) and non-Big Six (Five) audit firms. Binary logit regression is used to analyze 1,332 firms that were non-bankrupt but fina...

GOseek: a gene ontology search engine using enhanced keywords.

Science.gov (United States)

Taha, Kamal

2013-01-01

We propose in this paper a biological search engine called GOseek, which overcomes the limitation of current gene similarity tools. Given a set of genes, GOseek returns the most significant genes that are semantically related to the given genes. These returned genes are usually annotated to one of the Lowest Common Ancestors (LCA) of the Gene Ontology (GO) terms annotating the given genes. Most genes have several annotation GO terms. Therefore, there may be more than one LCA for the GO terms annotating the given genes. The LCA annotating the genes that are most semantically related to the given gene is the one that receives the most aggregate semantic contribution from the GO terms annotating the given genes. To identify this LCA, GOseek quantifies the contribution of the GO terms annotating the given genes to the semantics of their LCAs. That is, it encodes the semantic contribution into a numeric format. GOseek uses microarray experiment data to rank result genes based on their significance. We evaluated GOseek experimentally and compared it with a comparable gene prediction tool. Results showed marked improvement over the tool.

The Wheels of Stress Go 'Round and 'Round

Science.gov (United States)

Brey, Rebecca A.; Clark, Susan E.

2012-01-01

"The Wheels of Stress Go Round and Round" teaching idea uses three activity wheels to reinforce stress-related content and concepts. After presenting a definition of stress, the instructor assists students in identifying stressors, and aids in formulating a list of negative, reactive behaviors and a list of positive coping mechanisms. Using…

Financial and Non Financial Factors on Going-Concern Opinion

Directory of Open Access Journals (Sweden)

Junaidi Junaidi

2012-09-01

Full Text Available Company's ability to survive is a fundamental uncertainty faced in the preparation and auditing financial statements. Provision of going-concern opinion on these financial statements the company is still being debated. Public Accountant Professional Standards in section 341 states that the auditor is responsible for evaluating whether there is a major doubt on the ability of entities in the continued survival of the appropriate period of time, not more than one year from the date of the financial statements being audited. This research analyzed the financial and non financial factors that affected the provision of going-concern opinion. This research used samples of 63 companies with 315 observations, taken from years 2005-2009. The logistic regression analysis showed that the company's financial condition variables, mitigating evidence, and disclosure significantly influence the acceptance of going-concern opinion. Enterprise risk was not significant at propensity of going-concern opinion.

Study on Synthesis and Antibacterial Properties of Ag NPs/GO Nanocomposites

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Lei Huang

2016-01-01

Full Text Available Using graphene oxide as substrate and stabilizer for the silver nanoparticles, silver nanoparticles-graphene oxide (Ag NPs/GO composites with different Ag loading were synthesized through a facile solution-phase method. During the synthesis process, AgNO3 on GO matrix was directly reduced by NaBH4. The structure characterization was studied through X-ray diffraction (XRD, atomic force microscopy (AFM, high-resolution transmission electron microscope (HRTEM, ultraviolet-visible spectroscopy (UV-Vis, and selected area electron diffraction (SAED. The results show that Ag nanoparticles (Ag NPs with the sizes ranging from 5 to 20 nm are highly dispersed on the surfaces of GO sheets. The shape and size of the Ag NPs are decided by the volume of initial AgNO3 solution added in the GO. The antibacterial activities of Ag NPs/GO nanocomposites were investigated and the result shows that all the produced composites exhibit good antibacterial activities against Gram-negative (G− bacterial strain Escherichia coli (E. coli and Gram-positive (G+ strain Staphylococcus aureus (S. aureus. Moreover, the antibacterial activities of Ag NPs/GO nanocomposites gradually increased with the increasing of volume of initial AgNO3 solution added in the GO and this improvement of the antibacterial activities results from the combined action of size effect and concentration effect of Ag NPs in Ag NPs/GO nanocomposites.

Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task

Directory of Open Access Journals (Sweden)

Jie-Yu Chuang

2017-07-01

Full Text Available Compared to female major depressive disorder (MDD, male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11–18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD.

Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task.

Science.gov (United States)

Chuang, Jie-Yu; Hagan, Cindy C; Murray, Graham K; Graham, Julia M E; Ooi, Cinly; Tait, Roger; Holt, Rosemary J; Elliott, Rebecca; van Nieuwenhuizen, Adrienne O; Bullmore, Edward T; Lennox, Belinda R; Sahakian, Barbara J; Goodyer, Ian M; Suckling, John

2017-01-01

Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males. Twenty-four depressed and 10 healthy male adolescents, together with 82 depressed and 24 healthy female adolescents, aged 11-18 years, undertook an affective go/no-go task during fMRI acquisition. In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found. Furthermore, in contrast to the healthy male adolescents, depressed male adolescents showed decreased activation in the cerebellum with a significant group-by-age interaction in connectivity. Future research may consider altered developmental trajectories and the possible implications of sex-specific treatment and prevention strategies for MDD.

El Go como vía de acceso al pensamiento estratégico oriental / The game of Go as a way to access Eastern strategic thinking

Directory of Open Access Journals (Sweden)

Fernando Aguilar

2018-02-01

Full Text Available El manejo de los problemas estratégicos relacionados con la guerra tiene una particular concepción en las culturas orientales que difiere cualitativamente de la que predomina en el hemisferio occidental. La tradición estratégica oriental, en especial la china, encuentra su representación más sucinta en la obra El arte de la guerra, atribuida a Sun Tzu. El juego de Go, cuyo origen se remonta a la antigua China, opera presumiblemente con los mismos principios y conceptos expuestos por Sun Tzu; por tanto, su práctica constituye una vía privilegiada para acceder a estas concepciones mediante la experiencia directa del practicante o jugador. De acuerdo con el contenido de esos principios se realiza una síntesis del pensamiento de Sun Tzu a partir de la presentación de cinco pares conceptuales que responden a la polaridad yin–yang propia de la filosofía china y se muestra cómo estos se aplican en el planteo estratégico de una partida de Go. Abstract Eastern cultures have a particular conception as to the management of war-related strategic problems which qualitatively differs from that predominant of the Western Hemisphere. Eastern strategic tradition, particularly China´s, has its most concise representation in the book “The Art of War”, attributed to Sun Tzu. The game of Go, which originated in ancient China, presumably works under the same principles and concepts given by Sun Tzu. Therefore, its practice constitutes a privileged way to access these conceptions by means of the player´s direct experience. Bearing in mind the content of these principles, Sun Tzu´s thinking was synthesized by presenting five conceptual pairs that answered to the yin-yang polarity characteristic of Chinese philosophy, and those pairs proved to apply to the strategy of a game of Go.

Modeling Stop-and-Go Waves in Pedestrian Dynamics

OpenAIRE

Portz, Andrea; Seyfried, Armin

2010-01-01

Several spatially continuous pedestrian dynamics models have been validated against empirical data. We try to reproduce the experimental fundamental diagram (velocity versus density) with simulations. In addition to this quantitative criterion, we tried to reproduce stop-and-go waves as a qualitative criterion. Stop-and-go waves are a characteristic phenomenon for the single file movement. Only one of three investigated models satisfies both criteria.

Intestinal parasitosis in school going children of Dharan municipality, Nepal.

Science.gov (United States)

Gyawali, Narayan; Amatya, Ritu; Nepal, Hari Prasad

2009-01-01

This community-based investigation was carried out to estimate the prevalence of intestinal parasitosis in primary school-going children of the Dharan municipality, Sunsari, Nepal from 2007 through 2008. A total of 182 stool samples were collected from 101 male and 81 female children of ages 4 to 10 years. A questionnaire including the factors predisposing to parasitosis, was filled up by the parents of each child. Parasitic examination was carried out by direct wet mount examination and concentration method using 10% formol-ether. The prevalence rate was found to be 22.5%. The result revealed preponderance of Giardia lamblia (11.5%) followed by Entamoeba histolytica/dispar (4.4%), Ascaris lumbricoides (3.3%), hookworm (1.6%) and Enterobius vermicularis (0.5%). Statistically significant difference in the prevalence with respect to age and gender was not seen. However, socioeconomic status, type of toilet used and the practice of hand washing had a strong correlation (p intestinal parasitic infections.

OAHG: an integrated resource for annotating human genes with multi-level ontologies.

Science.gov (United States)

Cheng, Liang; Sun, Jie; Xu, Wanying; Dong, Lixiang; Hu, Yang; Zhou, Meng

2016-10-05

OAHG, an integrated resource, aims to establish a comprehensive functional annotation resource for human protein-coding genes (PCGs), miRNAs, and lncRNAs by multi-level ontologies involving Gene Ontology (GO), Disease Ontology (DO), and Human Phenotype Ontology (HPO). Many previous studies have focused on inferring putative properties and biological functions of PCGs and non-coding RNA genes from different perspectives. During the past several decades, a few of databases have been designed to annotate the functions of PCGs, miRNAs, and lncRNAs, respectively. A part of functional descriptions in these databases were mapped to standardize terminologies, such as GO, which could be helpful to do further analysis. Despite these developments, there is no comprehensive resource recording the function of these three important types of genes. The current version of OAHG, release 1.0 (Jun 2016), integrates three ontologies involving GO, DO, and HPO, six gene functional databases and two interaction databases. Currently, OAHG contains 1,434,694 entries involving 16,929 PCGs, 637 miRNAs, 193 lncRNAs, and 24,894 terms of ontologies. During the performance evaluation, OAHG shows the consistencies with existing gene interactions and the structure of ontology. For example, terms with more similar structure could be associated with more associated genes (Pearson correlation γ 2  = 0.2428, p < 2.2e-16).

BODY MASS STATUS AMONG PRIMARY SCHOOL GOING CHILDREN

Directory of Open Access Journals (Sweden)

Kashmala khan

2016-08-01

Full Text Available Background: School going children is important part of our society. Their growth, development and body weight is of utmost significance and presents general health status of a community and nation as a whole. For the assessment of nutritional status WHO Asian cuts-off BMI for age recommended BMI less than 18.5 kg/m considered underweight, 18.5-24.9 normal weight, more than 25 overweight. The objective of this study is to access body mass status among primary school going children of Hyderabad. Methods: The study design was cross sectional study in which different school of Hyderabad were selected to collect data (semi government and private sector.This study has assessed the body mass index between 7-14 years old age group of both genders of primary school going children of Hyderabad. BMI has calculated with the help of weight and height of the body. Result: In this study out of 100 children 10%were 7-8 year old 20% were 9-10 year old, 20% were 11-12year old and 30% were 13-14 year old. The analysis shows 80% were underweight (below 18.5, 18% were normal weight (18.5-24.9 and only 2% overweight (above 25 according to the Asian cut-off value of BMI for Asian children. When it was analyzed by gender 62% of the boys and 18% of the girls were underweight, 6% of boys and 12% out of girls were normal weight, 2% of the boys were overweight no girl found overweight in the study. In the above study 80% found underweight, 18% normal weight, 2% overweight. Conclusion: Under nutrition among the school going children is currently a health problem faced by Hyderabad school going children. There is need to be taken address these problems in order to prevent nation from nutritional deficiency among school going children and buildup a strong and healthy nation in future.

Going Local to Find Help

Science.gov (United States)

... Cover Story: Traumatic Brain Injury Going Local to Find Help Past Issues / Fall 2008 Table of Contents ... phone numbers, maps and directions, such as To Find Out More: Visit www.ninds.nih.gov/Disorders/ ...

Rapportering om going concern i den nye revisionspåtegning

DEFF Research Database (Denmark)

Seehausen, Jesper

2017-01-01

Artiklen omhandler revisors rapportering om going concern i den nye revisionspåtegning. Det er artiklens centrale budskab, at der i den nye revisionspåtegning alene er ændringer til, hvordan revisor skal rapportere om going concern i revisionspåtegningen. Der er derimod ikke ændringer til, hvornår...... revisor skal rapportere om going concern i revisionspåtegningen....

"Dance and go on": a project of psychosocial rehabilitation on the road.

Science.gov (United States)

Tavormina, Romina; Tavormina, Maurilio Giuseppe Maria; Nemoianni, Eugenio

2015-09-01

The project "Dance and go on" was created with the intention of bringing out of the Day Centre of the Department of Mental Health of Torre del Greco, the dance group "Dance That you go" active since 2009. Dancing Bachata becomes a rehabilitation tool to express emotions through the body and to open to the outside, on the territory (local society), overcoming the fear of being judged by others, the prejudice and the social stigma about mental illness. The rehabilitation activities of the dancing group allowed patients to improve their care of self, self-esteem, confidence in their capacities and an increase in their social relations. The strength and cohesion of the rehabilitation group has given to the patients the opportunity to believe in their own abilities, to accept themselves with their difficulties and to improve the relationship with their body in relation with each other.

Why Go to Speech Therapy?

Science.gov (United States)

... for stuttering to change over time or for emotions and attitudes about your speech to change as you have new experiences. It is important for you to have a clear idea about your motivation for going to therapy because your reasons for ...

GoQBot: a caterpillar-inspired soft-bodied rolling robot

International Nuclear Information System (INIS)

Lin, Huai-Ti; Trimmer, Barry; Leisk, Gary G

2011-01-01

Rolling locomotion using an external force such as gravity has evolved many times. However, some caterpillars can curl into a wheel and generate their own rolling momentum as part of an escape repertoire. This change in body conformation occurs well within 100 ms and generates a linear velocity over 0.2 m s -1 , making it one of the fastest self-propelled wheeling behaviors in nature. Inspired by this behavior, we construct a soft-bodied robot to explore the dynamics and control issues of ballistic rolling. This robot, called GoQBot, closely mimics caterpillar rolling. Analyzing the whole body kinematics and 2D ground reaction forces at the robot ground anchor reveals about 1G of acceleration and more than 200 rpm of angular velocity. As a novel rolling robot, GoQBot demonstrates how morphing can produce new modes of locomotion. Furthermore, mechanical coupling of the actuators improves body coordination without sensory feedback. Such coupling is intrinsic to soft-bodied animals because there are no joints to isolate muscle-generated movements. Finally, GoQBot provides an estimate of the mechanical power for caterpillar rolling that is comparable to that of a locust jump. How caterpillar musculature produces such power in such a short time is yet to be discovered.

GoQBot: a caterpillar-inspired soft-bodied rolling robot

Energy Technology Data Exchange (ETDEWEB)

Lin, Huai-Ti; Trimmer, Barry [Department of Biology, Tufts University, 163 Packard Avenue, Medford, MA 02155 (United States); Leisk, Gary G, E-mail: huaiti.lin@gmail.com, E-mail: gary.leisk@tufts.edu, E-mail: barry.trimmer@tufts.edu [Department of Mechanical Engineering, Tufts University, 200 College Avenue, Medford, MA 02155 (United States)

2011-06-15

Rolling locomotion using an external force such as gravity has evolved many times. However, some caterpillars can curl into a wheel and generate their own rolling momentum as part of an escape repertoire. This change in body conformation occurs well within 100 ms and generates a linear velocity over 0.2 m s{sup -1}, making it one of the fastest self-propelled wheeling behaviors in nature. Inspired by this behavior, we construct a soft-bodied robot to explore the dynamics and control issues of ballistic rolling. This robot, called GoQBot, closely mimics caterpillar rolling. Analyzing the whole body kinematics and 2D ground reaction forces at the robot ground anchor reveals about 1G of acceleration and more than 200 rpm of angular velocity. As a novel rolling robot, GoQBot demonstrates how morphing can produce new modes of locomotion. Furthermore, mechanical coupling of the actuators improves body coordination without sensory feedback. Such coupling is intrinsic to soft-bodied animals because there are no joints to isolate muscle-generated movements. Finally, GoQBot provides an estimate of the mechanical power for caterpillar rolling that is comparable to that of a locust jump. How caterpillar musculature produces such power in such a short time is yet to be discovered.

GoBusi omanikel jaks lõppemas / Kadri Bank

Index Scriptorium Estoniae

Bank, Kadri

2008-01-01

Ilmunud ka: Delovõje Vedomosti 6. aug. lk. 6. Kahjumis ja negatiivse omakapitaliga bussifirma GoBus omanikel on valida, kas investeerida ettevõttesse veel miljoneid või kuulutada ettevõte pankrotistunuks. Vt. samas: Konkurent: hea, et nad üldse veel elus on. Lisa: GoBus koondas väikesed bussifirmad. Kommenteerib Autoettevõtete Liidu sõitjateveo spetsialist Ivo Volt

Tungsten oxide-graphene oxide (WO3-GO) nanocomposite as an efficient photocatalyst, antibacterial and anticancer agent

Science.gov (United States)

Jeevitha, G.; Abhinayaa, R.; Mangalaraj, D.; Ponpandian, N.

2018-05-01

Functioning of ultrasonically prepared tungsten oxide-graphene oxide (WO3-GO) nanocomposite as a photocatalyst, antibacterial and anticancer system was investigated and the obtained results were compared with that of pure WO3 nanoparticles. Structural, morphological, compositional and optical properties of the prepared WO3 nanoparticles and WO3-GO nanocomposite were studied. Photocatalytic efficiency of the system on organic dyes such as methylene blue (MB, cationic) and indigo carmine (IC, anionic) was investigated. The enhanced efficiency of the WO3-GO nanocomposite system was evaluated under sunlight and compared with that of pure WO3. The degradation efficiency values for MB and IC were found to be 97.03% and 95.43% at 180 and 120 min respectively. Antibacterial activity of the WO3-GO nanocomposite under visible light was tested and improved inhibition results were observed for Escherichia coli and Bacillus subtilis after 6 h of light exposure. The photocatalytic degradation efficiency and antibacterial activity of the WO3-GO nanocomposite are attributed to the improved electron-hole pair separation rate. Investigation on anticancer activity of WO3-GO nanocomposite was tested on human lung cancer (A-549) cell line and the IC50 value was found to be 139.6 ± 4.53 μg/mL. The results obtained in this study may be used as a platform for the development of photocatalysis applications based on WO3-GO nanocomposite.

CeO2/rGO/Pt sandwich nanostructure: rGO-enhanced electron transmission between metal oxide and metal nanoparticles for anodic methanol oxidation of direct methanol fuel cells.

Science.gov (United States)

Yu, Xue; Kuai, Long; Geng, Baoyou

2012-09-21

Pt-based nanocomposites have been of great research interest. In this paper, we design an efficient MO/rGO/Pt sandwich nanostructure as an anodic electrocatalyst for DMFCs with combination of the merits of rigid structure of metallic oxides (MOs) and excellent electronic conductivity of reduced oxidized graphene (rGO) as well as overcoming their shortcomings. In this case, the CeO(2)/rGO/Pt sandwich nanostructure is successfully fabricated through a facile hydrothermal approach in the presence of graphene oxide and CeO(2) nanoparticles. This structure has a unique building architecture where rGO wraps up the CeO(2) nanoparticles and Pt nanoparticles are homogeneously dispersed on the surface of rGO. This novel structure endows this material with great electrocatalytic performance in methanol oxidation: it reduces the overpotential of methanol oxidation significantly and its electrocatalytic activity and stability are much enhanced compared with Pt/rGO, CeO(2)/Pt and Pt/C catalysts. This work supplies a unique MO/rGO/Pt sandwich nanostructure as an efficient way to improve the electrocatalytic performance, which will surely shed some light on the exploration of some novel structures of electrocatalyst for DMFCs.

Optimal no-go theorem on hidden-variable predictions of effect expectations

Science.gov (United States)

Blass, Andreas; Gurevich, Yuri

2018-03-01

No-go theorems prove that, under reasonable assumptions, classical hidden-variable theories cannot reproduce the predictions of quantum mechanics. Traditional no-go theorems proved that hidden-variable theories cannot predict correctly the values of observables. Recent expectation no-go theorems prove that hidden-variable theories cannot predict the expectations of observables. We prove the strongest expectation-focused no-go theorem to date. It is optimal in the sense that the natural weakenings of the assumptions and the natural strengthenings of the conclusion make the theorem fail. The literature on expectation no-go theorems strongly suggests that the expectation-focused approach is more general than the value-focused one. We establish that the expectation approach is not more general.

Understanding Going Concern in Auditing: Seker Poultry, Inc.

Directory of Open Access Journals (Sweden)

Ayca Zeynep Suer

2016-02-01

Full Text Available Under the going concern assumption, an entity is viewed as continuing in business for the foreseeable future. General purpose financial statements are prepared on a going concern basis, unless management either intends to liquidate the entity or to cease operations, or has no realistic alternative but to do so. In this case study, we examine the recent financial problems of Seker Poultry, Inc. – one of the listed companies in Borsa Istanbul –and their impacts on the financial statement audit process. This case provides an opportunity to examine the auditor‘s judgment process and responsibilities regarding the going concern assumption. This case uses information in Seker‘s recent publicly available financial statements and annual reports. The case can be used in undergraduate or graduate level audit courses.

Reliability analysis for power supply system in a reprocessing facility based on GO methodology

International Nuclear Information System (INIS)

Wang Renze

2014-01-01

GO methodology was applied to analyze the reliability of power supply system in a typical reprocessing facility. Based on the fact that tie breakers are set in the system, tie breaker operator was defined. Then GO methodology modeling and quantitative analysis were performed sequently, minimal cut sets and average unavailability of the system were obtained. Parallel analysis between GO methodology and fault tree methodology was also performed. The results showed that setup of tie breakers was rational and necessary and that the modeling was much easier and the chart was much more succinct for GO methodology parallel with fault tree methodology to analyze the reliability of the power supply system. (author)

Go Group andis avalöögi / Erki Freiberg

Index Scriptorium Estoniae

Freiberg, Erki

2005-01-01

Go Group on omandanud 17 turismi- ja reisijateveo ning nende tegevusvaldkondadega seotud ettevõtet ning planeerib selle aasta käibeks üle 600 miljoni krooni. Vt. samas: Go Groupi kuuluv Tarbus asub võitlusse soodsama transpordipoliitika nimel. Diagramm: Omanikud

Gene Ontology

Directory of Open Access Journals (Sweden)

Gaston K. Mazandu

2012-01-01

Full Text Available The wide coverage and biological relevance of the Gene Ontology (GO, confirmed through its successful use in protein function prediction, have led to the growth in its popularity. In order to exploit the extent of biological knowledge that GO offers in describing genes or groups of genes, there is a need for an efficient, scalable similarity measure for GO terms and GO-annotated proteins. While several GO similarity measures exist, none adequately addresses all issues surrounding the design and usage of the ontology. We introduce a new metric for measuring the distance between two GO terms using the intrinsic topology of the GO-DAG, thus enabling the measurement of functional similarities between proteins based on their GO annotations. We assess the performance of this metric using a ROC analysis on human protein-protein interaction datasets and correlation coefficient analysis on the selected set of protein pairs from the CESSM online tool. This metric achieves good performance compared to the existing annotation-based GO measures. We used this new metric to assess functional similarity between orthologues, and show that it is effective at determining whether orthologues are annotated with similar functions and identifying cases where annotation is inconsistent between orthologues.

Preparation and properties of GO-PVA composite hydrogel with oriented structure

Science.gov (United States)

Liu, Huanqing; Zhang, Gongzheng; Li, Huanjun

2017-03-01

We fabricated GO-PVA composite hydrogels with oriented structure by directional freezing and repeated freeze-thawing, which owned superior mechanical property and thermostability than PVA hydrogel. Due to physical interactions such as hydrogen bonding between surface of GO and PVA chains, GO-PVA composite hydrogel possessed higher crosslinking density and smaller pore size and can resist higher temperature and stronger force from outside than PVA hydrogel. These unique properties will endow GO-PVA hydrogel with greater potential application in biomedical materials.

Bitcoin's Potential for Going Mainstream

NARCIS (Netherlands)

Kasiyanto, Safari

2016-01-01

This paper reviews the possibility of bringing Bitcoin into the mainstream. In so doing, it elaborates the potential and obstacles of the Bitcoin system and what it would take for it to go mainstream. A cross-cutting discussion provides a helicopter view and encompasses the technical, economic,

Video-based self-review: comparing Google Glass and GoPro technologies.

Science.gov (United States)

Paro, John A M; Nazareli, Rahim; Gurjala, Anadev; Berger, Aaron; Lee, Gordon K

2015-05-01

Professionals in a variety of specialties use video-based review as a method of constant self-evaluation. We believe critical self-reflection will allow a surgical trainee to identify methods for improvement throughout residency and beyond. We have used 2 new popular technologies to evaluate their role in accomplishing the previously mentioned objectives. Our group investigated Google Glass and GoPro cameras. Medical students, residents, and faculty were invited to wear each of the devices during a scheduled operation. After the case, each participant was asked to comment on a number of features of the device including comfort, level of distraction/interference with operating, ease of video acquisition, and battery life. Software and hardware specifications were compiled and compared by the authors. A "proof-of-concept" was also performed using the video-conferencing abilities of Google Glass to perform a simulated flap check. The technical specifications of the 2 cameras favor GoPro over Google Glass. Glass records in 720p with 5-MP still shots, and the GoPro records in 1080p with 12-MP still shots. Our tests of battery life showed more than 2 hours of continuous video with GoPro, and less than 1 hour for Glass. Favorable features of Google Glass included comfort and relative ease of use; they could not comfortably wear loupes while operating, and would have preferred longer hands-free video recording. The GoPro was slightly more cumbersome and required a nonsterile team member to activate all pictures or video; however, loupes could be worn. Google Glass was successfully used in the hospital for a simulated flap check, with overall audio and video being transmitted--fine detail was lost, however. There are benefits and limitations to each of the devices tested. Google Glass is in its infancy and may gain a larger intraoperative role in the future. We plan to use Glass as a way for trainees to easily acquire intraoperative footage as a means to "review tape" and

Worry-inducing stimuli in an aversive Go/NoGo task enhance reactive control in individuals with lower trait-anxiety.

Science.gov (United States)

Leue, Anja; Rodilla, Carmen Cano; Beauducel, André

2017-04-01

This study relates predictions on reactive and proactive cognitive control to findings on anxious apprehension/worry and ERN/Ne. We investigated whether worry-inducing stimuli in an aversive performance setting lead to a more pronounced increase of the ERN/Ne in individuals with lower anxious apprehension/worry. We also explored the N2 amplitude in the context of worry-inducing stimuli. Fifty-eight participants performed an extended Go/NoGo task. A neutral or fearful face was presented at the beginning of each trial, with the fearful face as a worry-inducing, distracting stimulus. In an aversive feedback condition, aversive feedback was provided for false or too slow responses. We found a more pronounced decrease of the ERN/Ne after worry-inducing stimuli compared to neutral stimuli in participants with lower anxious apprehension/worry. Moreover, less pronounced N2 amplitudes were associated with shorter reaction times in the aversive feedback condition. Implications for future research on error monitoring and trait-anxiety are discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

76 FR 60960 - Gulf Opportunity Pilot Loan Program (GO Loan Pilot)

Science.gov (United States)

2011-09-30

... SMALL BUSINESS ADMINISTRATION Gulf Opportunity Pilot Loan Program (GO Loan Pilot) AGENCY: U.S.... SUMMARY: This notice announces the extension of SBA's GO Loan Pilot, with modifications, until December 31... processing available through the GO Loan Pilot to small businesses in the eligible parishes/counties through...

Synthesis and Characterization of Reduced Graphene Oxide/Rhodamine 101 (rGO-Rh101) Nanocomposites and Their Heterojunction Performance in rGO-Rh101/ p-Si Device Configuration

Science.gov (United States)

Batır, G. Güven; Arık, Mustafa; Caldıran, Zakir; Turut, Abdulmecit; Aydogan, Sakir

2018-01-01

Reduced graphene oxide (rGO)-rhodamine 101 (Rh101) nanocomposites with different ratios of rGO have been synthesized in aqueous medium by ultrasonic homogenization. The fluorescence of Rh101 as measured using a laser dye with high fluorescence quantum yield was substantially quenched with increasing amount of rGO in the nanocomposite. Formation of rGO-Rh101 nanocomposites was confirmed by x-ray diffraction analysis, scanning electron microscopy, ultraviolet-visible (UV-Vis) spectroscopy, and fluorescence microscopy. Furthermore, rGO-Rh101 nanocomposite/ p-Si heterojunctions were synthesized, all of which showed good rectifying behavior. The electrical characteristics of these devices were analyzed using current-voltage ( I- V) measurements to determine the ideality factor and barrier height. The experimental results confirmed the presence of lateral inhomogeneity in the effective barrier height of the rGO-Rh101 nanocomposite/ p-Si heterojunctions. In addition to I- V measurements, one device was analyzed in more detail using frequency-dependent capacitance-voltage measurements. All electrical measurements were carried out at room temperature and in the dark.

Superplasticity and Micro-arrayed Deep-Drawing Behavior of Ni-Co/GO Nanocomposite

Science.gov (United States)

Wang, Guofeng; Zhao, Shanshan; Li, You; Yang, Chao; Liu, Siyu

2017-10-01

In this article, Ni-Co/GO nanocomposite was fabricated by AC pulse electrodeposition method. The room temperature strength tests and the superplasticity of the nanocomposite were investigated by the tensile tests. A 5 × 5 micro-arrayed deep-drawing die was designed to explore the feasibility of micro-forming. The as-deposited material has a narrow grain size distribution with a mean grain size of 50 nm. The addition of GO as a reinforcing phase can effectively enhance the room temperature tensile strength of the nanocomposite, but reduce the plasticity. When adding GO to the plating bath, a maximum elongation of 467% was observed for the specimen with a GO content of 0.01 g/L at 773 K and a strain rate of 1.67 × 10-3 s-1 by tensile tests. Micro-arrayed deep-drawing tests were subsequently performed with male die diameter of 0.58 mm and female die diameter of 0.8 mm. The experimental relative drawing height values were measured and compared with the deep-drawing parts without GO additive. It is found that the micro-arrayed deep-drawing with rigid male die at high temperature was feasible and forming parts with good shape could be got. The thickness distribution analysis of the deep-drawing parts showed that wall thickness changed ranging from 53 to 95 μm, and the thickness reduction at the punch fillet is the most obvious.

Effect of concentration variation in graphene oxide (GO) membranes for water flux optimization

Science.gov (United States)

Kumar, Shani; Garg, Amit; Chowdhuri, Arijit

2018-05-01

Graphene oxide, sister material of Graphene has generated tremendous research interest in fields of energy storage, catalyst material, adsorbent material for heavy metals and dyes, green energy production, drug delivery agent, a gas sensing material as well as in membrane based water purification and desalination systems1-3 etc. In this paper, we are reporting the effect of concentration variation in GO membranes on water flux. GO has been synthesized by Hummer's method with related characterizations like XRD, Raman, SEM and FTIR carried out. GO membranes have been developed using pressure assisted filtration assembly (Water Vac-100) over Cellulose Acetate membrane support (47 mm dia. and 0.45 µm pore size), Millipore.

Genetics of Human Sexual Behavior: Where We Are, Where We Are Going.

Science.gov (United States)

Jannini, Emmanuele A; Burri, Andrea; Jern, Patrick; Novelli, Giuseppe

2015-04-01

One of the never-ending debates in the developing field of sexual medicine is the extent to which genetics and experiences (i.e., "nature and nurture") contribute to sexuality. The debate continues despite the fact that these two sides have different abilities to create a scientific environment to support their cause. Contemporary genetics has produced plenty of recent evidence, however, not always confirmed or sufficiently robust. On the other hand, the more traditional social theorists, frequently without direct evidence confirming their positions, criticize, sometimes with good arguments, the methods and results of the other side. The aim of this article is to critically evaluate existent evidence that used genetic approaches to understand human sexuality. An expert in sexual medicine (E.A.J.), an expert in medical genetics (G.N.), and two experts in genetic epidemiology and quantitative genetics, with particular scientific experience in female sexual dysfunction (A.B.) and in premature ejaculation (P.J.), contributed to this review. Expert opinion supported by critical review of the currently available literature. The existing literature on human sexuality provides evidence that many sexuality-related behaviors previously considered to be the result of cultural influences (such as mating strategies, attractiveness and sex appeal, propensity to fidelity or infidelity, and sexual orientation) or dysfunctions (such as premature ejaculation or female sexual dysfunction) seem to have a genetic component. Current evidence from genetic epidemiologic studies underlines the existence of biological and congenital factors regulating male and female sexuality. However, these relatively recent findings ask for replication in methodologically more elaborated studies. Clearly, increased research efforts are needed to further improve understanding the genetics of human sexuality. Jannini EA, Burri A, Jern P, and Novelli G. Genetics of human sexual behavior: Where we are, where

75 FR 53007 - Gulf Opportunity Pilot Loan Program (GO Loan Pilot)

Science.gov (United States)

2010-08-30

... SMALL BUSINESS ADMINISTRATION Gulf Opportunity Pilot Loan Program (GO Loan Pilot) AGENCY: U.S...'s GO Loan Pilot until September 30, 2011. Due to the scope and magnitude of the devastation to... streamlined and centralized loan processing available through the GO Loan Pilot to small businesses in the...

Conflict and inhibition differentially affect the N200/P300 complex in a combined go/nogo and stop-signal task.

Science.gov (United States)

Enriquez-Geppert, Stefanie; Konrad, Carsten; Pantev, Christo; Huster, René J

2010-06-01

Conflict and inhibition are considered to exert strong influences on the neurophysiological N200 and P300 brain responses as evoked in go/nogo and stop-signal tasks. In order to separate their underlying neural and functional mechanisms, the current experiment manipulated both conflict and inhibition. To do so, the go/nogo and stop-signal tasks were merged into one paradigm. Conflict was manipulated by varying go-trial frequencies across blocks (75% vs. 25%). Motor inhibition was manipulated by using go, nogo and stop trials each representing a different load of inhibition. Event-related potentials (ERPs) as well as current density reconstructions (CDRs) of fifteen healthy participants were analyzed. Overall, infrequent trials evoked significantly more pronounced N200s than frequent trials. The P300 predominantly revealed significant variations between trial types (go, nogo, stop). Estimated source activations of the MCC and the IFC supported the ERP results; N200-related effects were revealed in both regions, whereas the condition-specific variations of the P300 were only observed in the IFC. The results indicate that the N200 primarily reflects conflict-related effects whereas the P300 predominantly represents motor inhibition. Copyright 2010 Elsevier Inc. All rights reserved.

Reduced Prefrontal Cortex Activation in Children with Attention-Deficit/Hyperactivity Disorder during Go/No-Go Task: A Functional Near-Infrared Spectroscopy Study

Directory of Open Access Journals (Sweden)

Shuo Miao

2017-06-01

Full Text Available Objective: Attention-deficit/hyperactivity disorder (ADHD is one of the most common neuropsychiatric disorders in children and affects 3 to 5% of school-aged children. This study is to demonstrate whether functional near-infrared spectroscopy (fNIRS can detect the changes in the concentration of oxygenated hemoglobin (oxy-HB in children with ADHD and typically developing children (TD children.Method: In this study, 14 children with ADHD and 15 TD children were studied. Metabolic signals of functional blood oxygen were recorded by using fNIRS during go/no-go task. A statistic method is used to compare the fNIRS between the ADHD children and controls.Results: A significant oxy-HB increase in the left frontopolar cortex (FPC in control subjects but not in children with ADHD during inhibitory tasks. Moreover, ADHD children showed reduced activation in left FPC relative to TD children.Conclusion: Functional brain imaging using fNIRS showed reduced activation in the left prefrontal cortex (PFC of children with ADHD during the inhibition task. The fNIRS could be a promising tool for differentiating children with ADHD and TD children.

Segregating Top-Down Selective Attention from Response Inhibition in a Spatial Cueing Go/NoGo Task: An ERP and Source Localization Study.

Science.gov (United States)

Hong, Xiangfei; Wang, Yao; Sun, Junfeng; Li, Chunbo; Tong, Shanbao

2017-08-29

Successfully inhibiting a prepotent response tendency requires the attentional detection of signals which cue response cancellation. Although neuroimaging studies have identified important roles of stimulus-driven processing in the attentional detection, the effects of top-down control were scarcely investigated. In this study, scalp EEG was recorded from thirty-two participants during a modified Go/NoGo task, in which a spatial-cueing approach was implemented to manipulate top-down selective attention. We observed classical event-related potential components, including N2 and P3, in the attended condition of response inhibition. While in the ignored condition of response inhibition, a smaller P3 was observed and N2 was absent. The correlation between P3 and CNV during the foreperiod suggested an inhibitory role of P3 in both conditions. Furthermore, source analysis suggested that P3 generation was mainly localized to the midcingulate cortex, and the attended condition showed increased activation relative to the ignored condition in several regions, including inferior frontal gyrus, middle frontal gyrus, precentral gyrus, insula and uncus, suggesting that these regions were involved in top-down attentional control rather than inhibitory processing. Taken together, by segregating electrophysiological correlates of top-down selective attention from those of response inhibition, our findings provide new insights in understanding the neural mechanisms of response inhibition.

Georgia Health - Go Local: Using Multidisciplinary Partnerships to Promote a Statewide Consumer Health Website.

Science.gov (United States)

Smith, Rita B

2011-01-01

The National Library of Medicine ended its support of the Go Local program in 2010 due to declining usage, but in many ways Georgia's project was a success. From its beginning, Georgia Health - Go Local was a model of successful collaboration among a variety of partners and institutions throughout the state. The high usage statistics for the Go Local website and the support garnered by the project exemplify the positive nature of the collaborations that made the project possible.

Noncommutative gauge field theories: A no-go theorem

International Nuclear Information System (INIS)

Chaichian, M.; Tureanu, A.; Presnajder, P.; Sheikh-Jabbari, M.M.

2001-06-01

Studying the mathematical structure of the noncommutative groups in more detail, we prove a no-go theorem for the noncommutative gauge theories. According to this theorem, the closure condition of the gauge algebra implies that: 1) the local noncommutative u(n) algebra only admits the irreducible nxn matrix-representation. Hence the gauge fields, as elements of the algebra, are in nxn matrix form, while the matter fields can only be either in fundamental, adjoint or singlet states; 2) for any gauge group consisting of several simple group factors, the matter fields can transform nontrivially under at most two noncommutative group factors. In other words, the matter fields cannot carry more than two simple noncommutative gauge group charges. This no-go theorem imposes strong restrictions on the construction of the noncommutative version of the Standard Model and in resolving the standing problem of charge quantization in noncommutative QED. (author)

Third-order optical nonlinearity of N-doped graphene oxide nanocomposites at different GO ratios

Science.gov (United States)

Kimiagar, Salimeh; Abrinaei, Fahimeh

2018-05-01

In the present work, the influence of GO ratios on the structural, linear and nonlinear optical properties of nitrogen-doped graphene oxide nanocomposites (N-GO NCs) has been studied. N-GO NCs were synthesized by hydrothermal method. The XRD, FTIR, SEM, and TEM results confirmed the reduction of GO by nitrogen doping. The energy band gaps of N-GO NCs calculated from UV-Vis analyzed by using Tauc plot. To obtain further insight into potential optical changes in the N-GO NCs by increasing GO contents, Z-scan analysis was performed with nanosecond Nd-YAG laser at 532 nm. The nonlinear absorption coefficient, β, and nonlinear refractive index, n2, for N-GO NCs at the laser intensity of 113 MW/cm were measured and an increase was observed in both parameters after addition of nitrogen to GO. The third-order nonlinear optical susceptibilities of N-GO NCs were measured in the order of 10-9 esu. The results showed that N-GO NCs have negative nonlinearity which can be controlled by GO contents to obtain the highest values for nonlinear optical parameters. The nonlinear optical results not only imply that N-GO NCs can serve as an important material in the advancing of optoelectronics but also open new possibilities for the design of new graphene-based materials by variation of N and GO ratios as well as manufacturing conditions.

GoPro-kypäräkameran kuvakulmat extreme-urheiluvideoissa

OpenAIRE

Hypén, Anssi

2013-01-01

Opinnäytetyössä tutkitaan GoPro-valmistajan kypäräkameran tavallisimpia videoiden kuvakulmia extreme-urheilulajeissa. Kuvakulmia tutkitaan GoPro viralliseen Youtube-videopalveluun ladattujen videoiden kautta, josta on poimittu yleisimpiä kuvakulmia extreme-urheilulajeissa. GoPro-kypäräkamera on alunperin suunniteltu extreme- ja seikkailu-urheiluun, joten opinnäytetyössä tutkitut kuvakulmat on rajattu tarkastelemaan vain extreme-urheilulajeissa käytettyjä kuvakulmia. Extreme-urheiluvideois...

Interaction between behavioral inhibition and emotional processing in borderline personality disorder using a pictorial emotional go/no-go paradigm.

Science.gov (United States)

Sinke, Christopher; Wollmer, M Axel; Kneer, Jonas; Kahl, Kai G; Kruger, Tillmann H C

2017-10-01

Borderline personality disorder (BPD) is characterized by difficulties in emotional regulation and impulse control. In this study, we presented a novel picture-based emotional go/no-go task with distracting emotional faces in the background, which was administered to 16 patients with BPD and 16 age-matched healthy controls. The faces displayed different emotional content (angry, neutral, or happy). Results showed differences in sensitivity between patients and the control group, with patients exhibiting less sensitivity in the task, and also showed influences of emotional content represented in the distracting faces in both groups. Specifically, happy faces decreased sensitivity compared to angry faces. It seemed as though processing of a positive emotional stimulus led to a more relaxed state and thereby to decreased sensitivity, while a negative emotional stimulus induced more alertness and tension, leading to higher sensitivity. Thus, this paradigm is suitable to investigate the interplay between emotion processing and impulse control in patients with BPD. Copyright © 2017 Elsevier B.V. All rights reserved.

Going public and initial public offering: An exploratory study of motives from Serbian companies

Directory of Open Access Journals (Sweden)

Marinković Srđan

2012-06-01

Full Text Available The paper explores motives for and against going public, from the insider point of view. We employed tailor-made structured questionnaire framework to analyze advantages and disadvantages as perceived by CEO/controlling owners. Responses point out that most companies' insiders sees going public as being potentially beneficial strategy in terms of financial restructuring, efficiently combining its business to strategic alliances, possibility to divest, visibility and image of the company. The overall positive impression is offset with some disadvantages: costs and risks imposed to those who going public. Moreover, the sample is stratified in order to gain insights into how four companies' features influence the relative importance of the motives pro et contra going public. Finally, correlation matrix is employed to assess how logically robust are the responses.

Improved Sensitivity with Low Limit of Detection of a Hydrogen Gas Sensor Based on rGO-Loaded Ni-Doped ZnO Nanostructures.

Science.gov (United States)

Bhati, Vijendra Singh; Ranwa, Sapana; Rajamani, Saravanan; Kumari, Kusum; Raliya, Ramesh; Biswas, Pratim; Kumar, Mahesh

2018-04-04

We report enhanced hydrogen-gas-sensing performance of a Ni-doped ZnO sensor decorated with the optimum concentration of reduced graphene oxide (rGO). Ni-doped ZnO nanoplates were grown by radio frequency sputtering, rGO was synthesized by Hummer's method and decorated by the drop cast method of various concentration of rGO (0-1.5 wt %). The current-voltage characteristics of the rGO-loaded sensor are highly influenced by the loading concentration of rGO, where current conduction decreases and sensor resistance increases as the rGO concentration is increased up to 0.75 wt % because of the formation of various Schottky heterojunctions at rGO/ZnO interfaces. With the combined effect of more active site availability and formation of various p-n heterojunctions due to the optimum loading concentration of rGO (0.75 wt %), the sensor shows the maximum sensing response of ∼63.8% for 100 ppm hydrogen at moderate operating temperature (150 °C). The rGO-loaded sensors were able to detect a minimum of 1 ppm hydrogen concentration and showed high selectivity. However, a further increase in the rGO concentration (1.5 wt %) leads to the reduction of the relative response of hydrogen gas, ascribed to the formation of interconnections of rGO between electrodes. Therefore, it reduces the total resistance of the sensor and minimizes the effect of p-n heterojunction on sensor response.

Gene function prediction based on Gene Ontology Hierarchy Preserving Hashing.

Science.gov (United States)

Zhao, Yingwen; Fu, Guangyuan; Wang, Jun; Guo, Maozu; Yu, Guoxian

2018-02-23

Gene Ontology (GO) uses structured vocabularies (or terms) to describe the molecular functions, biological roles, and cellular locations of gene products in a hierarchical ontology. GO annotations associate genes with GO terms and indicate the given gene products carrying out the biological functions described by the relevant terms. However, predicting correct GO annotations for genes from a massive set of GO terms as defined by GO is a difficult challenge. To combat with this challenge, we introduce a Gene Ontology Hierarchy Preserving Hashing (HPHash) based semantic method for gene function prediction. HPHash firstly measures the taxonomic similarity between GO terms. It then uses a hierarchy preserving hashing technique to keep the hierarchical order between GO terms, and to optimize a series of hashing functions to encode massive GO terms via compact binary codes. After that, HPHash utilizes these hashing functions to project the gene-term association matrix into a low-dimensional one and performs semantic similarity based gene function prediction in the low-dimensional space. Experimental results on three model species (Homo sapiens, Mus musculus and Rattus norvegicus) for interspecies gene function prediction show that HPHash performs better than other related approaches and it is robust to the number of hash functions. In addition, we also take HPHash as a plugin for BLAST based gene function prediction. From the experimental results, HPHash again significantly improves the prediction performance. The codes of HPHash are available at: http://mlda.swu.edu.cn/codes.php?name=HPHash. Copyright © 2018 Elsevier Inc. All rights reserved.

A control-theoretic outlook at the no-go zone in sailing vessels

DEFF Research Database (Denmark)

Yang, Bin; Xiao, Lin; Jouffroy, Jerome

2011-01-01

Sailing vessels, due to their particular propulsive mechanism, gradually lose power as they face the wind, i.e. when they are in the so-called “no-go zone”. Interestingly, dynamical models of sailing vessels, which are usually quite complex, all have in common this no-go zone effect. Using...

Nano-Biocatalysts of Cyt c@ZIF-8/GO Composites with High Recyclability via a de Novo Approach.

Science.gov (United States)

Zhu, Qianqian; Zhuang, Wei; Chen, Yong; Wang, Zhanke; Villacorta Hernandez, Byron; Wu, Jinglan; Yang, Pengpeng; Liu, Dong; Zhu, Chenjie; Ying, Hanjie; Zhu, Zhonghua

2018-05-09

To improve the stability and recyclability of enzymes immobilized on metal-organic frameworks (MOFs), graphene oxide (GO) with surface oxygen-rich functional groups was selected to form ZIF-8/GO nanocomposites with the zeolitic imidazolate framework (ZIF-8) for cytochrome c (Cyt c) immobilization. It was found that the functional groups on the GO surface were involved in the growth of ZIF-8 without affecting the crystal structure but their particle size was reduced to about 200 nm. The storage stability and resistance to organic solvents of Cyt c were obviously improved after the immobilization on the ZIF-8/GO nanocomposite. On one hand, compared with Cyt c@ZIF-8 and Cyt c@GO with 30 and 60% protein leakage, Cyt c@ZIF-8/GO displayed little protein leakage after 60 h of storage. On the other hand, Cyt c@ZIF-8/GO retained a residual activity of approximately 100% after being stored in ethanol and acetone for 2 h, whereas the free enzyme, Cyt c@ZIF-8, and Cyt c@GO retained only about 10, 50, and 40%, respectively. In addition, the Cyt c@ZIF-8/GO nanocomposites can be utilized up to four cycles with virtually no loss of activity and may be further applied on H 2 O 2 biosensing systems. The synergistic effect between MOFs and GO in ZIF-8/GO nanocomposites provides infinite possibilities as immobilized enzyme carriers.

Going Concern Opinions and Management's Forward Looking Disclosures: Evidence from the MD&A

NARCIS (Netherlands)

Enev, M.; Geiger, Marshall; Gold, A.H.; Wallage, P.

In this study we examine the relationship between the auditor’s going concern opinion and management’s forward-looking disclosures in the Management’s Discussion and Analysis (MD&A) section of 10-K filings. The research objective is two-fold and addresses whether the presence of a going concern

DeepGO: predicting protein functions from sequence and interactions using a deep ontology-aware classifier.

Science.gov (United States)

Kulmanov, Maxat; Khan, Mohammed Asif; Hoehndorf, Robert; Wren, Jonathan

2018-02-15

A large number of protein sequences are becoming available through the application of novel high-throughput sequencing technologies. Experimental functional characterization of these proteins is time-consuming and expensive, and is often only done rigorously for few selected model organisms. Computational function prediction approaches have been suggested to fill this gap. The functions of proteins are classified using the Gene Ontology (GO), which contains over 40 000 classes. Additionally, proteins have multiple functions, making function prediction a large-scale, multi-class, multi-label problem. We have developed a novel method to predict protein function from sequence. We use deep learning to learn features from protein sequences as well as a cross-species protein-protein interaction network. Our approach specifically outputs information in the structure of the GO and utilizes the dependencies between GO classes as background information to construct a deep learning model. We evaluate our method using the standards established by the Computational Assessment of Function Annotation (CAFA) and demonstrate a significant improvement over baseline methods such as BLAST, in particular for predicting cellular locations. Web server: http://deepgo.bio2vec.net, Source code: https://github.com/bio-ontology-research-group/deepgo. robert.hoehndorf@kaust.edu.sa. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

What does Pokémon Go teach us about geography?

OpenAIRE

H. Gong; R. Hassink; G. Maus

2017-01-01

Pokémon Go, a highly popular, recently launched augmented-reality-based video game, fosters players' interaction with the real world. In this commentary we elaborate on how location-based games, such as Pokémon Go, have provided insights into the perception and understanding of space, as well as into their impact on patterns of mobility. In addition to that, we compare Pokémon Go with geocaching, another location-based game, to further elaborate on what Pokémon Go fails to do i...

Detection of Locally Over-Represented GO Terms in Protein-Protein Interaction Networks

Science.gov (United States)

LAVALLÉE-ADAM, MATHIEU; COULOMBE, BENOIT; BLANCHETTE, MATHIEU

2015-01-01

High-throughput methods for identifying protein-protein interactions produce increasingly complex and intricate interaction networks. These networks are extremely rich in information, but extracting biologically meaningful hypotheses from them and representing them in a human-readable manner is challenging. We propose a method to identify Gene Ontology terms that are locally over-represented in a subnetwork of a given biological network. Specifically, we propose several methods to evaluate the degree of clustering of proteins associated to a particular GO term in both weighted and unweighted PPI networks, and describe efficient methods to estimate the statistical significance of the observed clustering. We show, using Monte Carlo simulations, that our best approximation methods accurately estimate the true p-value, for random scale-free graphs as well as for actual yeast and human networks. When applied to these two biological networks, our approach recovers many known complexes and pathways, but also suggests potential functions for many subnetworks. Online Supplementary Material is available at www.liebertonline.com. PMID:20377456

Go Cook - de første 10 år

DEFF Research Database (Denmark)

Andersen, Boris

Med henvisning til evalueringens datagrundlag udpeges i arbejdsrapportens indsatsområder for fremtidens Go Cook (Go Cook er et landsdækkende tilbud til understøttelse af madkundskabs- og madlæringsaktiviter i grundskolen). De bliver tematiseret som følger: 1. Med henblik på at udvikle de didaktis...

The Geogenomic Mutational Atlas of Pathogens (GoMAP web system.

Directory of Open Access Journals (Sweden)

David P Sargeant

Full Text Available We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance. We engineered a new web system called Geogenomic Mutational Atlas of Pathogens (GoMAP that enables investigation of the global distribution of individual drug resistance mutations. As a test case we examined mutations associated with HIV resistance to FDA-approved antiretroviral drugs. GoMAP-HIV makes use of existing public drug resistance and HIV protein sequence data to examine the distribution of 872 drug resistance mutations in ∼ 502,000 sequences for many countries in the world. We also implemented a broadened classification scheme for HIV drug resistance mutations. Several patterns for geographic distributions of resistance mutations were identified by visual mining using this web tool. GoMAP-HIV is an open access web application available at http://www.bio-toolkit.com/GoMap/project/

A 'must-go path' scenario for sustainable development and the role of nuclear energy in the 21st century

International Nuclear Information System (INIS)

Jeong, Hae-Yong; Kim, Young-In; Lee, Yong-Bum; Ha, Kwi-Seok; Won, Byung-Chool; Lee, Dong-Uk; Hahn, Dohee

2010-01-01

An increase in the world population has accelerated the consumption of fossil fuels and deepened the pollution of global environment. As a result of these human activities, it is now difficult to clearly guarantee the sustainable future of humankind. An intuitional 'must-go path' scenario for the sustainable development of human civilization is proposed by extrapolating the human historical data over 30 years between 1970 and 2000. One of the most important parameters in order to realize the 'must-go path' scenario is the sustainability of energy without further pollution. In some countries an expanded use of nuclear energy is advantageous to increase sustainability, but fast reactor technology and closed fuel cycle have to be introduced to make it sustainable. In other countries, the development of cost-effective renewable energy, and the clean use of coal and oil are urgently needed to reduce pollution. The effect of fast nuclear reactor technology on sustainability as an option for near-term energy source is detailed in this paper. More cooperation between countries and worldwide collaboration coordinated by international organizations are essential to make the 'must-go path' scenario real in the upcoming 20 or 30 years.

Understanding Going Concern in Auditing: Seker Poultry, Inc.

OpenAIRE

Ayca Zeynep Suer; Ahmet Turel

2016-01-01

Under the going concern assumption, an entity is viewed as continuing in business for the foreseeable future. General purpose financial statements are prepared on a going concern basis, unless management either intends to liquidate the entity or to cease operations, or has no realistic alternative but to do so. In this case study, we examine the recent financial problems of Seker Poultry, Inc. – one of the listed companies in Borsa Istanbul –and their impacts on the financial stat...

Synthesis and biological evaluation of pyrrolidine derivatives as novel and potent sodium channel blockers for the treatment of ischemic stroke.

Science.gov (United States)

Seki, Maki; Tsuruta, Osamu; Tatsumi, Ryo; Soejima, Aki

2013-07-15

A novel series of pyrrolidine derivatives as Na(+) channel blockers was synthesized and evaluated for their inhibitory effects on neuronal Na(+) channels. Structure-activity relationship (SAR) studies of a pyrrolidine analogue 2 led to the discovery of 5e as a potent Na(+) channel blocker with a low inhibitory action against human ether-a-go-go-related gene (hERG) channels. Compound 5e showed remarkably neuroprotective activity in a rat transient middle cerebral artery occlusion (MCAO) model, suggesting that 5e would act as a neuroprotectant for ischemic stroke. Copyright © 2013 Elsevier Ltd. All rights reserved.

Improving Environmental Literacy through GO3 Citizen Science Project

Science.gov (United States)

Wilkening, B.

2011-12-01

In the Global Ozone (GO3) Project students measure ground-level ozone on a continuous basis and upload their results to a global network used by atmospheric scientists and schools. Students learn important concepts such as chemical measurement methods; instrumentation; calibration; data acquisition using computers; data quality; statistics; data analysis and graphing; posting of data to the web; the chemistry of air pollution; stratospheric ozone depletion and global climate change. Students collaborate with researchers and other students globally in the GO3 network. Wilson K-8 School is located in a suburban area in Pima County, Arizona. Throughout the year we receive high ozone alert days. Prior to joining the GO3 project, my students were unaware of air pollution alerts, risks and causes. In the past when Pima County issued alerts to the school, they were posted on signs around the school. No explanation was provided to the students and the signs were often left up for days. This discounted the potential health effects of the situation, resulting in the alerts effectively being ignored. The GO3 project is transforming both my students and our school community. Now my students are: Performing science research Utilizing technology and increasing their skills Collaborating in a responsible manner on the global GO3 social network Communicating their work to the community Issuing their own ozone alerts to their school Advocating for actions that will improve air quality My students participation in this citizen science project is creating a more cognizant and active community in regards to air pollution.

PENGARUH KONDISI KEUANGAN, PERTUMBUHAN DAN OPINI AUDIT TAHUN SEBELUMNYA TERHADAP OPINI AUDIT GOING CONCERN

Directory of Open Access Journals (Sweden)

Badingatus Solikhah

2012-03-01

Full Text Available Penelitian tentang going concern ditujukan untuk menguji secara empiris dampak kondisi keuangan corporate, perkembangan corporate dan opini audit tahun lalu terhadap opini audit going concern Data dikumpulkan dengan menggunakan content analysis dan metode dokumentasi dan diproses dengan Logistic Regression. Berdasarkan hasil penelitian, bukti empiris yang ditemukan adalah bahwa kondisi keuangan corporate opini audit tahun lalu berdampak signifikan terhadap penerimaan opini audit going concern. Namun sebaliknya variabel pertumbuhan corporate terbukti tidak signifikan terhadap penerimaan opini audit going concern. AbstractThe going concern research has a goal for testing empirically the effect of corporate financial condition, corporate growth, and last year audit opinion towards going concern audit opinion The data were collected by using content analysis and documentation methods, and processed by means of Logistic Regression. Based on the result of the study, empirical evidence is found that corporate financial condition and last year audit opinion has significant effect towards going concern audit opinion acceptance. In the contrary, corporate growth variable is proven insignificant towards going concern audit opinion acceptance.Keywords: audit opinion; going concern; logistic regression

Design and construction of a go-kart hybrid PEM fuel cell / rechargeable battery; Diseno y construccion de un go-kart hibrido pila de combustible PEM / bateria recargable

Energy Technology Data Exchange (ETDEWEB)

Suarez Alcantara, Karina; Rodriguez Castellanos, Andres; Soloza Feria, Omar [Centro de Investigacion y de Estudios Avanzados del IPN, Mexico D.F. (Mexico)]. E-mail: k.suarez.alcantara@gmail.com

2008-11-15

An hybrid Polymer Electrolyte Membrane Fuel Cell, PEMFC-Rechargeable Battery Go-kart has been designed and manufactured using AutoCAD software for the design and a CNC mechanical machine for the manufacture of components of the fuel cell. The membrane-electrode assemblies, MEAs, were integrated with a Gore-Select membrane and carbon cloth with Pt (20 wt % /C) 0.5 mg/cm{sup 2} anode and cathode electrode catalysts loading. High density graphite collector plates with 5mm thickness were used as collector plates. The estimated weigh of the go-kart with a driver is about 120 kg. The demand of the motor of the go-kart is 20 V and 5 A (100W), supplied by an hybrid system integrated by three 30Watts PEMFC. The commercially available Pb/acid rechargeable battery supplies energy for peripheral equipment. [Spanish] En este trabajo se presenta el diseno y la construccion de un go-kart hibrido pila de combustible con membrana de conduccion protonica tipo PEM (Proton Exchange Membrane, por sus siglas en ingles) y pila recargable. El diseno de los colectores de corriente de la pila se realizo utilizando el programa AutoCAD y la construccion mediante una fresadora con control numerico, CNC. Los ensambles membrana-electrocatalizador de la pila estan formados por membranas Gore-Select y por electrodos de Pt soportado en tela de carbon al 20 %peso/C con carga de 0.5 mg /cm{sup 2}, en anodo y catodo. Los platos colectores de corriente fueron manufacturados en grafito de alta densidad con espesor de 5 mm. La caracterizacion de la pila de combustible se realizo mediante ensayos de polarizacion potenciostatica. El peso total del go-kart y una persona a bordo es de 120 kg. La potencia del go-kart es generada por un motor de corriente directa de 20 V y 5 A (100 Watts). Para tal efecto, se construyeron tres pilas de combustible de 30 W cada una, con un respaldo de baterias recargables comerciales de Pb/acido para energizar equipos perifericos.

The discovery of tropane-derived CCR5 receptor antagonists.

Science.gov (United States)

Armour, Duncan R; de Groot, Marcel J; Price, David A; Stammen, Blanda L C; Wood, Anthony; Perros, Manos; Burt, Catherine

2006-04-01

The development of compound 1, a piperidine-based CCR5 receptor antagonist with Type I CYP2D6 inhibition, into the tropane-derived analogue 5, is described. This compound, which is devoid of CYP2D6 liabilities, is a highly potent ligand for the CCR5 receptor and has broad-spectrum activity against a range of clinically relevant HIV isolates. The identification of human ether a-go-go-related gene channel inhibition within this series is described and the potential for QTc interval prolongation discussed. Furthermore, structure activity relationship (SAR) around the piperidine moiety is also described.

Personhood: Fukuyama’s Caveats and Ishiguro’s Never Let Me Go

Directory of Open Access Journals (Sweden)

Kristine Brown

2015-07-01

Full Text Available Together, fiction and rhetoric not only illustrate grim possibilities, but also the processes and rationale by which they occur. Kazuo Ishiguro’s dystopian novel Never Let Me Go (2005 documents the lives of cloned children in twentieth century England whose sole purpose is to provide organs to keep their human predecessors alive. While the children mature to become donors or caregivers to peers undergoing donation, nothing exempts them from death following repeated organ harvesting. However unnerving, the novel tells of potential realities associated with genetic engineering, a trend bioconservative political scientist Francis Fukuyama addresses in his work Our Post Human Future. This article endeavors to present Never Let Me Go as a fictional, yet appropriate supplement to Fukuyama’s writing, incorporating new historicism and accentuating Fukuyama’s points of caution in Ishiguro’s novel. Through dissecting and discerning the complementary relationship of the two works, readers may garner enriched perspectives in debates on cloning and other forms of bioengineering.   Keywords: genetic engineering; cloning; eugenics; ethics; dystopia; speculation

GoPro as an Ethnographic Tool: A Wayfinding Study in an Academic Library

Science.gov (United States)

Kinsley, Kirsten M.; Schoonover, Dan; Spitler, Jasmine

2016-01-01

In this study, researchers sought to capture students' authentic experience of finding books in the main library using a GoPro camera and the think-aloud protocol. The GoPro provided a first-person perspective and was an effective ethnographic tool for observing a student's individual experience, while also demonstrating what tools they use to…

Ether formulations of relativity

International Nuclear Information System (INIS)

Duffy, M.C.

1980-01-01

Contemporary ether theories are surveyed and criticised, especially those formally identical to orthodox Relativity. The historical development of Relativity, Special and General, in terms of an ether, is briefly indicated. Classical interpretations of Generalized Relativity using ether are compared to Euclidean formulations using a background space. The history of a sub-group of theories, formulating a 'new' Relativity involving modified transforms, is outlined. According to the theory with which they agree, recent supposed detections of drift are classified and criticised. Cosmological evidence suggesting an ether is mentioned. Only ether theories formally identical to Relativity have been published in depth. They stand criticised as being contrary to the positivist spirit. The history of mechanical analogues is traced, from Hartley's representing gravitating matter as spherical standing waves, to recent suggestions that vortex-sponge might model electromagnetic, quantum, uncertainty and faster-than-light phenomena. Contemporary theories are particular physical theories, themselves 'second interpretations' of a primary mathematical model. Mechanical analogues are auxiliary, not necessary, to other theory, disclosing relationships between classical and non-classical descriptions of assemblies charging state. The ether-relativity polemic, part of a broader dispute about relativity, is founded on mistaken conceptions of the roles of mathematical and physical models, mechanical analogues; and a distored view of history, which indicates that ether theories have become relativistic. (author)

Electrophysiological correlates of anterior cingulate function in a go/no-go task: Effects of response conflict and trial type frequency.

NARCIS (Netherlands)

Nieuwenhuis, S.; Yeung, N.; van den Wildenberg, W.; Ridderinkhof, K.R.

2003-01-01

Neuroimaging and computational modeling studies have led to the suggestion that response conflict monitoring by the anterior cingulate cortex plays a key role in cognitive control. For example, response conflict is high when a response must be withheld (no-go) in contexts in which there is a

17 CFR 229.1014 - (Item 1014) Fairness of the going-private transaction.

Science.gov (United States)

2010-04-01

... market prices; (iii) Net book value; (iv) Going concern value; (v) Liquidation value; (vi) Purchase..., going concern value and future prospects of the issuer” will not be considered sufficient disclosure in... going-private transaction. 229.1014 Section 229.1014 Commodity and Securities Exchanges SECURITIES AND...

Pok\\'emon Go: Impact on Yelp Restaurant Reviews

OpenAIRE

Kondamudi, Pavan Ravikanth; Protono, Bradley; Alhoori, Hamed

2017-01-01

Pok\\'emon Go, the popular Augmented Reality based mobile application, launched in July of 2016. The game's meteoric rise in usage since that time has had an impact on not just the mobile gaming industry, but also the physical activity of players, where they travel, where they spend their money, and possibly how they interact with other social media applications. In this paper, we studied the impact of Pok\\'emon Go on Yelp reviews. For restaurants near Pok\\'eStops, we found a slight drop in th...

Investigation of UK Farmer Go/No-Go Decisions in Response to Tractor-Based Risk Scenarios.

Science.gov (United States)

Irwin, Amy; Poots, Jill

2018-01-01

Tractors are a source of injury and fatality in agriculture. Despite this farmers continue to engage in risk-taking behaviors, including operating tractors without appropriate equipment. In order to change behaviors and attitudes toward safety, it is important to understand how farmers approach different types of risk relevant to tractor use. The current study used a qualitative approach to investigate farmer perception of four types of tractor-based risk related to self, equipment, lack of safety features, and environment. A sample of 148 farmers from the United Kingdom and Ireland was recruited from farming forums to take part in an online scenario-based qualitative study. Participants were presented with 12 tractor-based scenarios, three from each category of risk, and asked to indicate if they would proceed to use the tractor (go) or not (no-go), then report their reasoning. Thematic analysis was used to identify data patterns. Farmers appeared to assess the consequences of risk in broader terms than the risk of injury to themselves; they also evaluated risk in terms of potential costs (e.g., repair bill) and losses (e.g., delay). Analysis indicated that financial risk was considered with more caution than personal risk in many cases. Farmers also considered usability, such as the functionality of tractor seat belts, indicating the importance of ensuring all safety equipment is fit for purpose. The management of agricultural risk should consider farmer priorities (such as financial costs) in order to develop effective messaging that focuses on those priorities, with the aim of reducing risk-taking behaviors.

Managing the data deluge: data-driven GO category assignment improves while complexity of functional annotation increases.

Science.gov (United States)

Gobeill, Julien; Pasche, Emilie; Vishnyakova, Dina; Ruch, Patrick

2013-01-01

The available curated data lag behind current biological knowledge contained in the literature. Text mining can assist biologists and curators to locate and access this knowledge, for instance by characterizing the functional profile of publications. Gene Ontology (GO) category assignment in free text already supports various applications, such as powering ontology-based search engines, finding curation-relevant articles (triage) or helping the curator to identify and encode functions. Popular text mining tools for GO classification are based on so called thesaurus-based--or dictionary-based--approaches, which exploit similarities between the input text and GO terms themselves. But their effectiveness remains limited owing to the complex nature of GO terms, which rarely occur in text. In contrast, machine learning approaches exploit similarities between the input text and already curated instances contained in a knowledge base to infer a functional profile. GO Annotations (GOA) and MEDLINE make possible to exploit a growing amount of curated abstracts (97 000 in November 2012) for populating this knowledge base. Our study compares a state-of-the-art thesaurus-based system with a machine learning system (based on a k-Nearest Neighbours algorithm) for the task of proposing a functional profile for unseen MEDLINE abstracts, and shows how resources and performances have evolved. Systems are evaluated on their ability to propose for a given abstract the GO terms (2.8 on average) used for curation in GOA. We show that since 2006, although a massive effort was put into adding synonyms in GO (+300%), our thesaurus-based system effectiveness is rather constant, reaching from 0.28 to 0.31 for Recall at 20 (R20). In contrast, thanks to its knowledge base growth, our machine learning system has steadily improved, reaching from 0.38 in 2006 to 0.56 for R20 in 2012. Integrated in semi-automatic workflows or in fully automatic pipelines, such systems are more and more efficient

GO-FLOW methodology. Basic concept and integrated analysis framework for its applications

International Nuclear Information System (INIS)

Matsuoka, Takeshi

2010-01-01

GO-FLOW methodology is a success oriented system analysis technique, and is capable of evaluating a large system with complex operational sequences. Recently an integrated analysis framework of the GO-FLOW has been developed for the safety evaluation of elevator systems by the Ministry of Land, Infrastructure, Transport and Tourism, Japanese Government. This paper describes (a) an Overview of the GO-FLOW methodology, (b) Procedure of treating a phased mission problem, (c) Common cause failure analysis, (d) Uncertainty analysis, and (e) Integrated analysis framework. The GO-FLOW methodology is a valuable and useful tool for system reliability analysis and has a wide range of applications. (author)

The Ethics of Going Public.

Science.gov (United States)

Kirsch, Jeffrey W.

1982-01-01

Social scientists who communicate scientific information via the media face challenges because they do not realize that journalists have values different from theirs. Discusses motivations that impel scientists to go public, the conflicting roles into which they, therefore, are cast, and the reasons why journalists regard scientists with…

Going outdoors and cognitive function among community-dwelling older adults: Moderating role of physical function.

Science.gov (United States)

Harada, Kazuhiro; Lee, Sangyoon; Park, Hyuntae; Shimada, Hiroyuki; Makizako, Hyuma; Doi, Takehiko; Yoshida, Daisuke; Tsutsumimoto, Kota; Anan, Yuya; Uemura, Kazuki; Suzuki, Takao

2016-01-01

Identifying the risk factors of cognitive impairment is essential for implementing effective prevention strategies for dementia. Previous studies have shown that the frequency of going outdoors is inversely associated with cognitive decline. Little research has examined whether the relationship between going outdoors and cognitive decline varies with physical functioning in older adults. The aim of the present study was to examine the relationship between going outdoors and cognitive function in older adults with and without physical function limitations. The present study analyzed the data of 4450 individuals (aged 65 years or older) who participated in the Obu Study of Health Promotion for the Elderly. The measures were the Mini-Mental State Examination (MMSE), going outdoors (at least once a week or not), self-reported physical function limitations (with or without), and demographic and health-related factors as potential confounders. Analysis of covariance and post-hoc comparisons showed that although going outdoors at least once a week was associated with higher MMSE scores among older adults with limited physical function, it was not significantly associated with the MMSE scores among older adults without limited physical function. Similarly, logistic regression analyses, stratified by physical function, showed a significant association between going outdoors and MMSE (older adults with limited physical function. The results show that going outdoors less than once a week is associated with decreased cognitive function among older adults with limited physical function, but it is not associated with cognitive function among older adults without limited physical function. © 2015 Japan Geriatrics Society.

Designing inquiry learning spaces for online labs in the Go-Lab platform

NARCIS (Netherlands)

de Jong, Ton; Gillet, Dennis; Sotiriou, Sofoklis; Agogi, Ellinogermaniki; Zacharia, Zacharias

2015-01-01

The Go-Lab project (http://www.go-lab-project.eu/) aims to enable the integration of online labs through inquiry-based learning approaches into science classrooms. Through the use of an advanced plug and play technological solution the Go-Lab project opens up remote science laboratories, data

Thorough specification of the neurophysiologic processes underlying behavior and of their manifestation in EEG - demonstration with the go/no-go task.

Science.gov (United States)

Shahaf, Goded; Pratt, Hillel

2013-01-01

In this work we demonstrate the principles of a systematic modeling approach of the neurophysiologic processes underlying a behavioral function. The modeling is based upon a flexible simulation tool, which enables parametric specification of the underlying neurophysiologic characteristics. While the impact of selecting specific parameters is of interest, in this work we focus on the insights, which emerge from rather accepted assumptions regarding neuronal representation. We show that harnessing of even such simple assumptions enables the derivation of significant insights regarding the nature of the neurophysiologic processes underlying behavior. We demonstrate our approach in some detail by modeling the behavioral go/no-go task. We further demonstrate the practical significance of this simplified modeling approach in interpreting experimental data - the manifestation of these processes in the EEG and ERP literature of normal and abnormal (ADHD) function, as well as with comprehensive relevant ERP data analysis. In-fact we show that from the model-based spatiotemporal segregation of the processes, it is possible to derive simple and yet effective and theory-based EEG markers differentiating normal and ADHD subjects. We summarize by claiming that the neurophysiologic processes modeled for the go/no-go task are part of a limited set of neurophysiologic processes which underlie, in a variety of combinations, any behavioral function with measurable operational definition. Such neurophysiologic processes could be sampled directly from EEG on the basis of model-based spatiotemporal segregation.

Going the Extra Mile

Energy Technology Data Exchange (ETDEWEB)

Wilkerson, Andrea M.

2016-02-01

Why do those in the lighting industry continue to volunteer? How do they keep going year after year as busy, successful professionals? These are questions that have crossed my mind many times as I have witnessed people throughout the lighting industry who not only dutifully renew their professional memberships each year, but continue to contribute their time and talent. So I asked a few of the many dedicated professionals these questions during the 2015 IES Annual Conference.

AIGO: Towards a unified framework for the Analysis and the Inter-comparison of GO functional annotations

Directory of Open Access Journals (Sweden)

Defoin-Platel Michael

2011-11-01

Full Text Available Abstract Background In response to the rapid growth of available genome sequences, efforts have been made to develop automatic inference methods to functionally characterize them. Pipelines that infer functional annotation are now routinely used to produce new annotations at a genome scale and for a broad variety of species. These pipelines differ widely in their inference algorithms, confidence thresholds and data sources for reasoning. This heterogeneity makes a comparison of the relative merits of each approach extremely complex. The evaluation of the quality of the resultant annotations is also challenging given there is often no existing gold-standard against which to evaluate precision and recall. Results In this paper, we present a pragmatic approach to the study of functional annotations. An ensemble of 12 metrics, describing various aspects of functional annotations, is defined and implemented in a unified framework, which facilitates their systematic analysis and inter-comparison. The use of this framework is demonstrated on three illustrative examples: analysing the outputs of state-of-the-art inference pipelines, comparing electronic versus manual annotation methods, and monitoring the evolution of publicly available functional annotations. The framework is part of the AIGO library (http://code.google.com/p/aigo for the Analysis and the Inter-comparison of the products of Gene Ontology (GO annotation pipelines. The AIGO library also provides functionalities to easily load, analyse, manipulate and compare functional annotations and also to plot and export the results of the analysis in various formats. Conclusions This work is a step toward developing a unified framework for the systematic study of GO functional annotations. This framework has been designed so that new metrics on GO functional annotations can be added in a very straightforward way.

Healthy Aging with Go4Life

Science.gov (United States)

... of this page please turn JavaScript on. Feature: Healthy Aging Healthy Aging with Go4Life ® Past Issues / Winter 2015 Table of ... is to make physical activity a cornerstone of healthy aging, for a simple reason. Being physically active is ...

Going Digital in Rural America.

Science.gov (United States)

Malecki, Edward J.

This paper examines the extent to which rural America is digital--has access to the Internet and to newer technologies such as wireless broadband--and discusses rural supply and demand for "going digital." Supply aspects include issues of both infrastructure and public policy. Demand aspects include entrepreneurs (business users) and…

Go green choices : a regional employer TDM program

Energy Technology Data Exchange (ETDEWEB)

Mackniak, C.; Hartley-Folz, S. [Better Environmentally Sound Transportation (BEST), Vancouver, BC (Canada)

2002-07-01

Go Green Choices is a regional, voluntary, employer-based trip reduction program initiated in 1994 by BC Transit. It is now funded by the TransLink Regional Transportation Authority in Vancouver. This presentation described how the program got started and the services it delivers. The 1990 Go Green Campaign in Vancouver increased awareness about transportation issues and air quality problems. Transportation demand management (TDM) was used to address traffic congestion issues and to help reduce the number of car trips. The presentation demonstrated how workplace trip reduction programs can be promoted by highlighting their benefits such as reduced stress for employees, retaining and recruiting valuable staff, higher productivity and performance due to low absenteeism. It also reduces the need for parking. The following case studies were presented: (1) Crystal Decision wanted to attract high quality young employees, so their choice of location was near walking and cycling paths, and they had no subsidized parking, and (2) the Vancouver Airport Authority developed innovative trip reduction plans and are considering the possibility of a new express bus to the airport.

Soil pH mapping with an on-the-go sensor.

Science.gov (United States)

Schirrmann, Michael; Gebbers, Robin; Kramer, Eckart; Seidel, Jan

2011-01-01

Soil pH is a key parameter for crop productivity, therefore, its spatial variation should be adequately addressed to improve precision management decisions. Recently, the Veris pH Manager™, a sensor for high-resolution mapping of soil pH at the field scale, has been made commercially available in the US. While driving over the field, soil pH is measured on-the-go directly within the soil by ion selective antimony electrodes. The aim of this study was to evaluate the Veris pH Manager™ under farming conditions in Germany. Sensor readings were compared with data obtained by standard protocols of soil pH assessment. Experiments took place under different scenarios: (a) controlled tests in the lab, (b) semicontrolled test on transects in a stop-and-go mode, and (c) tests under practical conditions in the field with the sensor working in its typical on-the-go mode. Accuracy issues, problems, options, and potential benefits of the Veris pH Manager™ were addressed. The tests demonstrated a high degree of linearity between standard laboratory values and sensor readings. Under practical conditions in the field (scenario c), the measure of fit (r(2)) for the regression between the on-the-go measurements and the reference data was 0.71, 0.63, and 0.84, respectively. Field-specific calibration was necessary to reduce systematic errors. Accuracy of the on-the-go maps was considerably higher compared with the pH maps obtained by following the standard protocols, and the error in calculating lime requirements was reduced by about one half. However, the system showed some weaknesses due to blockage by residual straw and weed roots. If these problems were solved, the on-the-go sensor investigated here could be an efficient alternative to standard sampling protocols as a basis for liming in Germany.

Development of the GO-FLOW reliability analysis methodology for nuclear reactor system

International Nuclear Information System (INIS)

Matsuoka, Takeshi; Kobayashi, Michiyuki

1994-01-01

Probabilistic Safety Assessment (PSA) is important in the safety analysis of technological systems and processes, such as, nuclear plants, chemical and petroleum facilities, aerospace systems. Event trees and fault trees are the basic analytical tools that have been most frequently used for PSAs. Several system analysis methods can be used in addition to, or in support of, the event- and fault-tree analysis. The need for more advanced methods of system reliability analysis has grown with the increased complexity of engineered systems. The Ship Research Institute has been developing a new reliability analysis methodology, GO-FLOW, which is a success-oriented system analysis technique, and is capable of evaluating a large system with complex operational sequences. The research has been supported by the special research fund for Nuclear Technology, Science and Technology Agency, from 1989 to 1994. This paper describes the concept of the Probabilistic Safety Assessment (PSA), an overview of various system analysis techniques, an overview of the GO-FLOW methodology, the GO-FLOW analysis support system, procedure of treating a phased mission problem, a function of common cause failure analysis, a function of uncertainty analysis, a function of common cause failure analysis with uncertainty, and printing out system of the results of GO-FLOW analysis in the form of figure or table. Above functions are explained by analyzing sample systems, such as PWR AFWS, BWR ECCS. In the appendices, the structure of the GO-FLOW analysis programs and the meaning of the main variables defined in the GO-FLOW programs are described. The GO-FLOW methodology is a valuable and useful tool for system reliability analysis, and has a wide range of applications. With the development of the total system of the GO-FLOW, this methodology has became a powerful tool in a living PSA. (author) 54 refs

Automated one-loop calculations with GoSam

International Nuclear Information System (INIS)

Cullen, Gavin; Greiner, Nicolas; Heinrich, Gudrun; Reiter, Thomas; Luisoni, Gionata; Mastrolia, Pierpaolo; Ossola, Giovanni; Tramontano, Francesco

2012-01-01

We present the program package GoSam which is designed for the automated calculation of one-loop amplitudes for multi-particle processes in renormalisable quantum field theories. The amplitudes, which are generated in terms of Feynman diagrams, can be reduced using either D-dimensional integrand-level decomposition or tensor reduction. GoSam can be used to calculate one-loop QCD and/or electroweak corrections to Standard Model processes and offers the flexibility to link model files for theories Beyond the Standard Model. A standard interface to programs calculating real radiation is also implemented. We demonstrate the flexibility of the program by presenting examples of processes with up to six external legs attached to the loop. (orig.)

Automated One-Loop Calculations with GoSam

CERN Document Server

Cullen, Gavin; Heinrich, Gudrun; Luisoni, Gionata; Mastrolia, Pierpaolo; Ossola, Giovanni; Reiter, Thomas; Tramontano, Francesco

2012-01-01

We present the program package GoSam which is designed for the automated calculation of one-loop amplitudes for multi-particle processes in renormalisable quantum field theories. The amplitudes, which are generated in terms of Feynman diagrams, can be reduced using either D-dimensional integrand-level decomposition or tensor reduction. GoSam can be used to calculate one-loop QCD and/or electroweak corrections to Standard Model processes and offers the flexibility to link model files for theories Beyond the Standard Model. A standard interface to programs calculating real radiation is also implemented. We demonstrate the flexibility of the program by presenting examples of processes with up to six external legs attached to the loop.

Closing to Scaling-Up High Reversible Si/rGO Nanocomposite Anodes for Lithium Ion Batteries

International Nuclear Information System (INIS)

Tokur, Mahmud; Algul, Hasan; Ozcan, Seyma; Cetinkaya, Tugrul; Uysal, Mehmet; Akbulut, Hatem

2016-01-01

Highlights: • rGO wrapped Si composite anodes for li-ion batteries were prepared by a hybrid assembly and followed by GO reduction. • To improve mechanical bonding between rGO and Si nanoparticles, mechanical alloying method was performed. • Different Si/rGO composite mixtures were prepared to investigate electrochemical performance of composite anodes. - Abstract: In spite of its excellent discharge capacity, low conductivity and poor cycling stability prevent to commercialize silicon negative electrodes for the Lithium ion batteries (LIBs). Since graphene has large surface area, high electrical conductivity and discharge capacity, silicon/graphene nanocomposite anodes in proper architectures alleviate difficulties to improve electrochemical performances of the LIBs. This article demonstrates the nanocomposite synthesizing with 10 wt.%, 30 wt.% and 50 wt.% graphene oxide (GO) dispersion in the silicon matrix following reduction of GO (rGO) result in remarkable improvements in the discharge capacity, cycle stability and rate capability. Mechanical milling after GO reduction provides decoration of silicon nanoparticles between the rGO sheets and improves interfacial bonding between silicon and rGO which alleviates huge volume increase during cycling. Among the nanocomposite negative electrodes, 50 wt.% rGO exhibits highest reversible capacity of about 2000 mAh g −1 after 100 cycles and good coulombic efficiency approximately 99%. This study proves that dispersion of silicon with rGO and the increase content of rGO lead to improve ionic conductivity, cycling stability, reversibility and rate capability of the Lithium ion cell. Because of the easy scaling-up possibility of the method Si/rGO hybrid nanocomposites can be new electrodes for electrochemical energy storage. .

Go Natural : a new fast food concept

OpenAIRE

Coelho, João Miguel Rodrigues

2013-01-01

Go Natural is a 100% Portuguese healthy fast food chain that was created by two siblings’ entrepreneurs, Diogo and Joana Martorell, whom had the wish to make something different. This company was chosen to serve as the setting of a Teaching Marketing study, with the purpose of being used as a pedagogical tool in undergraduate programs. This case provides students the opportunity to become familiar with brand expansions and the fast food market. In 2004, this pioneer brand provi...

The Game "Pokemon Go" as a Crosscultural Phenomenon

Science.gov (United States)

Koroleva, D. O.; Kochervey, A. I.; Nasonova, K. M.; Shibeko, Yu. V.

2016-01-01

The gaming culture of modern childhood takes place not only in real space, but in a virtual one too. These two components (two planes of development) are often viewed in isolation from one another. This study investigates the completely new phenomenon of augmented reality gaming through the lens of "Pokemon Go," and it describes how the…

WHY NATIONS GO TO WAR

African Journals Online (AJOL)

Francois Vrey

This 11th edition of Why nations go to war analyses ten case studies covering major ... of the time (Germany, Russia, Serbia and Austria in particular), Stoessinger depicts ... The section on the war in Vietnam depicts how five consecutive American ... to war. The nuclear option is available to both countries and the strategic.

Georgia Health – Go Local: Using Multidisciplinary Partnerships to Promote a Statewide Consumer Health Website

OpenAIRE

Smith, Rita B.

2011-01-01

The National Library of Medicine ended its support of the Go Local program in 2010 due to declining usage, but in many ways Georgia's project was a success. From its beginning, Georgia Health – Go Local was a model of successful collaboration among a variety of partners and institutions throughout the state. The high usage statistics for the Go Local website and the support garnered by the project exemplify the positive nature of the collaborations that made the project possible.

Going to the dogs

OpenAIRE

Petsko, Gregory A

2008-01-01

The article analyses the fourth detective novel by Julian Barnes «Going to the Dogs» written under an assumed name Dan Kavanagh. Appealing to the genre of classic English detective fiction, Barnes proceedes with the veiled experiments with genre. Furthermore the author manages with the canonical elements of the comprised «formula» of English detective fiction in a postmodern way, which in the atmosphere of questionable morality and overall criminal setting of London at the end of the XXth cen...

“DOCTOR! Go for a course in HR Management”

African Journals Online (AJOL)

doctors. Good HRM facilitates many of the foundational principles of family medicine. ... as I go along” is often the sum of a ... Business has to be planned, and HRM is an important part of the planning. ... Whether selecting new staff or reorgan-.

Nouvelles mythologies : La GoPro

OpenAIRE

Tomasovic, Dick

2015-01-01

A la manière des mythologies de Roland Barthes, et à la demande de la rédaction du Focus Vif, une analyse des discours accompagnant la caméra "GoPro", mais aussi des pratiques audiovisuelles liées à cette caméra ultraportable ainsi qu'à l'esthétique et la circulation de ses images.

Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.

Science.gov (United States)

Wu, Wei; Sanguinetti, Michael C

2016-06-01

Human cardiomyocytes express 3 distinct types of delayed rectifier potassium channels. Human ether-a-go-go-related gene (hERG) channels conduct the rapidly activating current IKr; KCNQ1/KCNE1 channels conduct the slowly activating current IKs; and Kv1.5 channels conduct an ultrarapid activating current IKur. Here the authors provide a general overview of the mechanistic and structural basis of ion selectivity, gating, and pharmacology of the 3 types of cardiac delayed rectifier potassium ion channels. Most blockers bind to S6 residues that line the central cavity of the channel, whereas activators interact with the channel at 4 symmetric binding sites outside the cavity. Copyright © 2016 Elsevier Inc. All rights reserved.

49 CFR 1103.21 - How far a practitioner may go in supporting a client's cause.

Science.gov (United States)

2010-10-01

... client's cause. 1103.21 Section 1103.21 Transportation Other Regulations Relating to Transportation... of Ethics The Practitioner's Duties and Responsibilities Toward A Client § 1103.21 How far a practitioner may go in supporting a client's cause. A practitioner shall put forth his best effort to maintain...

No-go for tree-level R-symmetry breaking

Energy Technology Data Exchange (ETDEWEB)

Liu, Feihu [University of Electronic Science and Technology of China, School of Physical Electronics, Chengdu (China); Liu, Muyang [Sichuan University, Center for Theoretical Physics, College of Physical Science and Technology, Chengdu (China); Sun, Zheng [Sichuan University, Center for Theoretical Physics, College of Physical Science and Technology, Chengdu (China); Chinese Academy of Sciences, CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China)

2017-11-15

We show that in gauge mediation models with tree-level R-symmetry breaking where supersymmetry and R-symmetries are broken by different fields, the gaugino mass either vanishes at one loop or finds a contribution from loop-level R-symmetry breaking. Thus tree-level R-symmetry breaking for phenomenology is either no-go or redundant in the simplest type of models. Including explicit messenger mass terms in the superpotential with a particular R-charge arrangement is helpful to bypass the no-go theorem, and the resulting gaugino mass is suppressed by the messenger mass scale. (orig.)

What did the Go4Health policy research project contribute to the policy discourse on the sustainable development goals? A reflexive review.

Science.gov (United States)

Te, Vannarath; Floden, Nadia; Hussain, Sameera; Brolan, Claire E; Hill, Peter S

2018-05-16

In 2012, the European Commission funded Go4Health-Goals and Governance for Global Health, a consortium of 13 academic research and human rights institutions from both Global North and South-to track the evolution of the Sustainable Development Goals (SDGs), and provide ongoing policy advice. This paper reviews the research outputs published between 2012 and 2016, analyzing the thematic content of the publications, and the influence on global health and development discourse through citation metrics. Analysis of the 54 published papers showed 6 dominant themes related to the SDGs: the formulation process for the SDG health goal; the right to health; Universal Health Coverage; voices of marginalized peoples; global health governance; and the integration of health across the other SDGs. The papers combined advocacy---particularly for the right to health and its potential embodiment in Universal Health Coverage-with qualitative research and analysis of policy and stakeholders. Go4Health's publications on the right to health, global health governance and the voices of marginalized peoples in relation to the SDGs represented a substantial proportion of papers published for these topics. Go4Health analysis of the right to health clarified its elements and their application to Universal Health Coverage, global health governance, financing the SDGs and access to medicines. Qualitative research identified correspondence between perceptions of marginalized peoples and right to health principles, and reluctance among multilateral organizations to explicitly represent the right to health in the goals, despite their acknowledgement of their importance. Citation metrics analysis confirmed an average of 5.5 citations per paper, with a field-weighted citation impact of 2.24 for the 43 peer reviewed publications. Citations in the academic literature and UN policy documents confirmed the impact of Go4Health on the global discourse around the SDGs, but within the Go4Health consortium

Societal perception toward transportation modes based on online (Go-Jek) In Malang City

Science.gov (United States)

Buamona, D. M.

2017-06-01

Driver online which is renowned as Go-jek is one of alternative transportation exist in Malang city based on IT. This service is supportive enough for all societies and easy to do serving, namely it is enough by using Go-jek application which is exist in Smartphone. Some services served by Go-jek including Go-Ride, Go-Car, Go-Food, Go-Send dan Go- Massage. By the development of technology and the emergence of alternative transportation, it will not close any chance to get competition.In its development some Go-Jek users started complaining about the services provided. This study aims is to assess the level of importance and performance and measure the level of community satisfaction in using Go-Jek with the method of Importance Performance Analysis (IPA) and Customer Satisfaction Index (CSI), Importance Performance Analysis (IPA) is used to determine the attributes of importance and level of satisfaction of performance while the Customer Satisfaction Index (CSI) is used to view the percentage of satisfaction level. Accidental Sampling technique is used to determine the sample based on spontaneity factor as well as for data collection using questionnaires with 100 respondents. The results of this study indicate that services considered important by the community but less attention namely waiting time for short reservations, ability to reach a specific location. Drivers deliver you to the right destination and reliability. For percentage of respondent satisfaction level, it is seen from several criteria: a) 0,81-1,00 Very satisfied, b) 0,66-0,80 Satisfied, c) 0,51-0,65 Simply satisfied, d) 0,35 -0.50 Less satisfied, and d) 0.00-0.34 Very dissatisfied. From the results of this study, it shows that people feel very satisfied with the service given today with a value of 0.84 CSI, this value is at the interval of 0.81-1.00. Based on the results of the analysis, although the percentage of this study shows high level of satisfaction of the respondents but the service

A modified GO-FLOW methodology with common cause failure based on Discrete Time Bayesian Network

International Nuclear Information System (INIS)

Fan, Dongming; Wang, Zili; Liu, Linlin; Ren, Yi

2016-01-01

Highlights: • Identification of particular causes of failure for common cause failure analysis. • Comparison two formalisms (GO-FLOW and Discrete Time Bayesian network) and establish the correlation between them. • Mapping the GO-FLOW model into Bayesian network model. • Calculated GO-FLOW model with common cause failures based on DTBN. - Abstract: The GO-FLOW methodology is a success-oriented system reliability modelling technique for multi-phase missions involving complex time-dependent, multi-state and common cause failure (CCF) features. However, the analysis algorithm cannot easily handle the multiple shared signals and CCFs. In addition, the simulative algorithm is time consuming when vast multi-state components exist in the model, and the multiple time points of phased mission problems increases the difficulty of the analysis method. In this paper, the Discrete Time Bayesian Network (DTBN) and the GO-FLOW methodology are integrated by the unified mapping rules. Based on these rules, the multi operators can be mapped into DTBN followed by, a complete GO-FLOW model with complex characteristics (e.g. phased mission, multi-state, and CCF) can be converted to the isomorphic DTBN and easily analyzed by utilizing the DTBN. With mature algorithms and tools, the multi-phase mission reliability parameter can be efficiently obtained via the proposed approach without considering the shared signals and the various complex logic operation. Meanwhile, CCF can also arise in the computing process.

[Multiple mere exposure effect: category evaluation measured in the Go/No-go association task (GNAT)].

Science.gov (United States)

Kawakami, Naoaki; Yoshida, Fujio

2011-12-01

The effect on likability of multiple subliminal exposures to the same person was investigated. Past studies on the mere exposure effect indicated a correlation between the frequency of repeated exposure to the same stimulus and likability. We proposed that exposure to various stimuli of the same person would have a stronger effect on likability. Participants were subliminally exposed to photographs of a person's face taken from seven angles (multi-angle-exposure) three times each (Experiment 1), or photographs of a person with seven facial expressions (multi-expression-exposure) three times each (Experiment 2). Then, the likability toward the exposed person was measured using the Go/No-go Association Task. The results indicated that the effect of the multiple exposures from various angles was equivalent to exposure to only one full-face photograph shown 21 times (Experiment 1). Moreover, likability was significantly higher in the case of exposure to various facial expressions than for exposure to only a single facial expression (Experiment 2). The results suggest that exposure to various stimuli in a category is more effective than repeated exposure to a single stimulus for increasing likability.

GoPro HERO 4 Black recording of scleral buckle placement during retinal detachment repair.

Science.gov (United States)

Ho, Vincent Y; Shah, Vaishali G; Yates, David M; Shah, Gaurav K

2017-08-01

GoPro and Google Glass technology have previously been used to record procedures in ophthalmology and other medical fields. In this manuscript, GoPro's latest HERO 4 Black edition camera (GoPro Inc, San Mateo, Calif.) will be used to record the placement of a scleral buckle during retinal detachment surgery. GoPro HERO 4 Black edition camera, which records 4K-quality video with a resolution of 3840 (pixels) x 2160 (lines), was mounted on a head strap to record placement of a scleral buckle for a retinal detachment. Excellent video quality was achieved with the 4K SuperView setting. Bluetooth connection with an Apple iPad (Apple Inc, Cupertino, Calif.) provided live streaming and use of the GoPro App. Zoom, horizontal/vertical alignment, exposure, and contrast adjustments were made with postproduction editing on GoPro Studio software. Video recording with the GoPro HERO 4 Black edition camera is an excellent way to document extraocular procedures to improve medical education, self-training, or medicolegal documentation. Copyright © 2017 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

Healthcare Encounters for Pokémon Go: Risks and Benefits of Playing.

Science.gov (United States)

Barbero, Erika M; Carpenter, Diane M; Maier, Joetta; Tseng, Daniel S

2018-04-30

Our aim was to quantify the health risks and benefits of Pokémon Go, an augmented reality game played on the mobile phone utilizing real-world locations. Healthcare encounters containing references to Pokémon Go in Kaiser Permanente Northern California (KPNC) from July 5, 2016 to November 5, 2016 were reviewed. Subjects were classified according to the nature of the healthcare encounter subsequent to playing Pokémon Go: adverse event/injury, self-reported benefit, or incidental mention. Comparisons were made using the Wilcoxon-Mann-Whitney nonparametric test where variables were continuous and the chi-squared or Fisher's exact test where variables were binomial. Of 222 Pokémon Go players reporting an adverse event or benefit, 75 (33.8%) experienced adverse events and 147 (66.2%) reported benefits. Among our cohort, 114 subjects (54.0%) were obese, and 62 (27.9%) were diabetic or prediabetic. More subjects reporting benefits had an endocrine-related comorbidity than those reporting injuries (40.1% vs. 16.0%, P benefit group than in the adverse event group ($83,846 vs. $70,378, P = 0.027). Of 75 subjects having adverse events, 8 (10.7%) had severe injuries, including fractures and head trauma, with 4 (5.3%) having inpatient stays. Most adverse events were musculoskeletal or skin injuries (n = 51, 68.0%). Injuries were similar to those seen with other light-to-moderate outdoor physical activities. Given KPNC's membership of 3.85 million, the number of severe injuries reported was low; this suggests that the game is safe to play. Pokémon Go may be reaching a population that requires increased physical activity.

Pengaruh Kinerja Keuangan Perusahaan Dan Opini Audit Tahun Sebelumnya Terhadap Opini Audit Mengenai Going Concern

OpenAIRE

Setiyanti, Sri Wiranti

2010-01-01

Companies that receive a going-concern opinion in the previous year wen more likely to receive the same opinion on the current year. Ramadhani (2004) proved that the going-concern audit opinion received the previous year positive impact on acceptance going-concern audit opinion for the year. If previous years the auditor has issued a going-concern audit opinion, the auditors will be more likely to issue going concern audit opinions again next year.Kata kunc...

Parallel nano-assembling of a multifunctional GO/HapNP coating on ultrahigh-purity magnesium for biodegradable implants

International Nuclear Information System (INIS)

Santos, C.; Piedade, C.; Uggowitzer, P.J.; Montemor, M.F.; Carmezim, M.J.

2015-01-01

Graphical abstract: - Highlights: • A GO/HapNP thin coating was applied on XHP-Mg using a parallel nano-assembling route. • The coating surface wettability can be controlled by adding HapNP and/or GO. • Nanostructured GO/HapNP/phosphate coating promotes the apatite mineralization. • Critical properties, including degradation on SBF, of the coating were studied. - Abstract: This work reports the one-step fabrication of a novel coating on ultra high purity magnesium using a parallel nano assembling process. The multifunctional biodegradable surface was obtained by adding hydroxyapatite nanoparticles (HapNP) plus graphene oxide (GO). The coating was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffractometer (XRD), micro-Raman spectroscopy. The thin phosphate coating (thickness of 1 μm) reveals a uniform coverage with cypress like structures. The incorporation of HapNP and GO promotes the hydrophilic behavior of the coating surface. The results revealed that the proposed coating can be used to tailor the surface properties such as wettability by adjusting the contents of HapNP and GO. The in vitro degradation rate of the coated magnesium suggests that the presence of HapNP and GO/HapNP in the phosphate coating decreased the current density compared to the single phosphate coating and uncoated magnesium. This study also reveals the HapNP/GO/phosphate coating induces apatite formation, showing suitable degradability that makes it a promising coating candidate for enhanced bone regeneration

Parallel nano-assembling of a multifunctional GO/HapNP coating on ultrahigh-purity magnesium for biodegradable implants

Energy Technology Data Exchange (ETDEWEB)

Santos, C., E-mail: catarina.santos@estsetubal.ips.pt [EST Setúbal, DEM, Instituto Politécnico de Setúbal, Campus IPS, 2914-508 Setúbal (Portugal); CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Piedade, C. [EST Setúbal, DEM, Instituto Politécnico de Setúbal, Campus IPS, 2914-508 Setúbal (Portugal); Uggowitzer, P.J. [Laboratory of Metal Physics and Technology, ETH Zurich, 8093 Zurich (Switzerland); Montemor, M.F. [CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Carmezim, M.J. [EST Setúbal, DEM, Instituto Politécnico de Setúbal, Campus IPS, 2914-508 Setúbal (Portugal); CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal)

2015-08-01

Graphical abstract: - Highlights: • A GO/HapNP thin coating was applied on XHP-Mg using a parallel nano-assembling route. • The coating surface wettability can be controlled by adding HapNP and/or GO. • Nanostructured GO/HapNP/phosphate coating promotes the apatite mineralization. • Critical properties, including degradation on SBF, of the coating were studied. - Abstract: This work reports the one-step fabrication of a novel coating on ultra high purity magnesium using a parallel nano assembling process. The multifunctional biodegradable surface was obtained by adding hydroxyapatite nanoparticles (HapNP) plus graphene oxide (GO). The coating was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffractometer (XRD), micro-Raman spectroscopy. The thin phosphate coating (thickness of 1 μm) reveals a uniform coverage with cypress like structures. The incorporation of HapNP and GO promotes the hydrophilic behavior of the coating surface. The results revealed that the proposed coating can be used to tailor the surface properties such as wettability by adjusting the contents of HapNP and GO. The in vitro degradation rate of the coated magnesium suggests that the presence of HapNP and GO/HapNP in the phosphate coating decreased the current density compared to the single phosphate coating and uncoated magnesium. This study also reveals the HapNP/GO/phosphate coating induces apatite formation, showing suitable degradability that makes it a promising coating candidate for enhanced bone regeneration.

Supporting Information Synthesis Procedure: Graphene oxide (GO ...