WorldWideScience

Sample records for human equivalent power

  1. Tissue Engineered Human Skin Equivalents

    Directory of Open Access Journals (Sweden)

    Zheng Zhang

    2012-01-01

    Full Text Available Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery and/or the body (transdermal delivery. In the past three decades, research and development in human skin equivalents have advanced in parallel with those in tissue engineering and regenerative medicine. The human skin equivalents are used commercially as clinical skin substitutes and as models for permeation and toxicity screening. Several academic laboratories have developed their own human skin equivalent models and applied these models for studying skin permeation, corrosivity and irritation, compound toxicity, biochemistry, metabolism and cellular pharmacology. Various aspects of the state of the art of human skin equivalents are reviewed and discussed.

  2. Equivalent Relaxations of Optimal Power Flow

    Energy Technology Data Exchange (ETDEWEB)

    Bose, S; Low, SH; Teeraratkul, T; Hassibi, B

    2015-03-01

    Several convex relaxations of the optimal power flow (OPF) problem have recently been developed using both bus injection models and branch flow models. In this paper, we prove relations among three convex relaxations: a semidefinite relaxation that computes a full matrix, a chordal relaxation based on a chordal extension of the network graph, and a second-order cone relaxation that computes the smallest partial matrix. We prove a bijection between the feasible sets of the OPF in the bus injection model and the branch flow model, establishing the equivalence of these two models and their second-order cone relaxations. Our results imply that, for radial networks, all these relaxations are equivalent and one should always solve the second-order cone relaxation. For mesh networks, the semidefinite relaxation and the chordal relaxation are equally tight and both are strictly tighter than the second-order cone relaxation. Therefore, for mesh networks, one should either solve the chordal relaxation or the SOCP relaxation, trading off tightness and the required computational effort. Simulations are used to illustrate these results.

  3. Development of an Equivalent Wind Plant Power-Curve: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Wan, Y. H.; Ela, E.; Orwig, K.

    2010-06-01

    Development of an equivalent wind plant power-curve becomes highly desirable and useful in predicting plant output for a given wind forecast. Such a development is described and summarized in this paper.

  4. Power curve report - with rotor equivalent wind speed

    DEFF Research Database (Denmark)

    Villanueva, Héctor; Gómez Arranz, Paula

    This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here......, the reference wind speed used in the power curve is the equivalent wind speed obtained from lidar measurements at several heights between lower and upper blade tip, in combination with a hub height meteorological mast. The measurements have been performed using DTU’s measurement equipment, the analysis...

  5. Barrier properties of human skin equivalents : rising to the surface

    NARCIS (Netherlands)

    Thakoersing, Varsha Sakina

    2012-01-01

    Human skin equivalents (HSEs) are generated from isolated skin cells. As the primary function of the skin is to form a barrier, in this thesis the barrier properties of three HSEs were assessed and compared with native human skin. The results show that all HSEs have a decreased skin barrier function

  6. Human Power Empirically Explored

    NARCIS (Netherlands)

    Jansen, A.J.

    2011-01-01

    Harvesting energy from the users’ muscular power to convert this into electricity is a relatively unknown way to power consumer products. It nevertheless offers surprising opportunities for product designers; human-powered products function independently from regular power infrastructure, are conven

  7. Pumpless microfluidic platform for drug testing on human skin equivalents

    OpenAIRE

    Abaci, Hasan Erbil; Gledhill, Karl; Guo, Zongyou; Christiano, Angela M.; Shuler, Michael L.

    2015-01-01

    Advances in bio-mimetic in vitro human skin models increase the efficiency of drug screening studies. In this study, we designed and developed a microfluidic platform that allows for long-term maintenance of full thickness human skin equivalents (HSE) which are comprised of both the epidermal and dermal compartments. The design is based on the physiologically relevant blood residence times in human skin tissue and allows for the establishment of an air-epidermal interface which is crucial for...

  8. Human Power Empirically Explored

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, A.J.

    2011-01-18

    Harvesting energy from the users' muscular power to convert this into electricity is a relatively unknown way to power consumer products. It nevertheless offers surprising opportunities for product designers; human-powered products function independently from regular power infrastructure, are convenient and can be environmentally and economically beneficial. This work provides insight into the knowledge required to design human-powered energy systems in consumer products from a scientific perspective. It shows the developments of human-powered products from the first introduction of the BayGen Freeplay radio in 1995 till current products and provides an overview and analysis of 211 human-powered products currently on the market. Although human power is generally perceived as beneficial for the environment, this thesis shows that achieving environmental benefit is only feasible when the environmental impact of additional materials in the energy conversion system is well balanced with the energy demands of the products functionality. User testing with existing products showed a preference for speeds in the range of 70 to 190 rpm for crank lengths from 32 to 95 mm. The muscular input power varied from 5 to 21 W. The analysis of twenty graduation projects from the Faculty of Industrial Design Engineering in the field of human-powered products, offers an interesting set of additional practice based design recommendations. The knowledge based approach of human power is very powerful to support the design of human-powered products. There is substantial potential for improvements in the domains energy conversion, ergonomics and environment. This makes that human power, when applied properly, is environmentally and economically competitive over a wider range of applications than thought previously.

  9. Proton scattering power of some tissue-equivalent plastics

    CERN Document Server

    Vasiliev, V N; Khaybullin, V G; Samarin, S I; Uglov, A S

    2010-01-01

    Proton scattering in some water and tissue equivalent phantom materials was measured to evaluate their simulation accuracy of water and respective human biological tissues. The measurements were performed on the medical facility of the ITEP synchrotron, proton energy was 219 MeV, a narrow beam was formed by a 3 mm collimator. A stack of plastic slabs was set closely to the collimator hole as a scatterer. Three types of Plastic Water (PW, PW LR and PW DT), lung, cortical bone, adipose and muscle plastics (CIRS Inc., USA) were used in the experiments as the substitutes under investigation and liquid water and PMMA slabs as reference materials. Dose (intensity) profiles were measured for each sample by two orthogonal strips of the Gafchromic EBT film. A total thickness of the plastic slab was from 4 to 16 cm depending on the material. The Gafchromic film response nonlinearity was taken into account by an additional calibration vs. absorbed dose in a wide proton beam, the temporal irradiation-to-scanning dependen...

  10. Equivalence of optical and electrical noise equivalent power of hybrid NbTiN-Al microwave kinetic inductance detectors

    Energy Technology Data Exchange (ETDEWEB)

    Janssen, R. M. J., E-mail: r.m.j.janssen@tudelft.nl [Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628CJ Delft (Netherlands); Endo, A. [Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628CJ Delft (Netherlands); Department of Microelectronics, Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), Delft University of Technology, Mekelweg 4, 2628 CD Delft (Netherlands); Visser, P. J. de [Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628CJ Delft (Netherlands); SRON Netherlands Institute for Space Research, Sorbonnelaan 2, 3584CA Utrecht (Netherlands); Klapwijk, T. M. [Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628CJ Delft (Netherlands); Physics Department, Moscow State Pedagogical University, Moscow 119991 (Russian Federation); Baselmans, J. J. A. [SRON Netherlands Institute for Space Research, Sorbonnelaan 2, 3584CA Utrecht (Netherlands)

    2014-11-10

    We have measured and compared the response of hybrid NbTiN-Al Microwave Kinetic Inductance Detectors (MKIDs) to changes in bath temperature and illumination by sub-mm radiation. We show that these two stimulants have an equivalent effect on the resonance feature of hybrid MKIDs. We determine an electrical noise equivalent power (NEP) from the measured temperature responsivity, quasiparticle recombination time, superconducting transition temperature, and noise spectrum, all of which can be measured in a dark environment. For the two hybrid NbTiN-Al MKIDs studied in detail, the electrical NEP is within a factor of two of the optical NEP, which is measured directly using a blackbody source.

  11. Equivalent dose rate by muons to the human body.

    Science.gov (United States)

    Băcioiu, I

    2011-11-01

    In this paper, the relative sensitivity from different human tissues of the human body, at a ground level, from muon cosmic radiation has been studied. The aim of this paper was to provide information on the equivalent dose rates received from atmospheric muons to human body, at the ground level. The calculated value of the effective dose rate by atmospheric muons plus the radiation levels of the natural annual background radiation dose, at the ground level, in the momentum interval of cosmic ray muon (0.2-120.0 GeV/c) is about 2.106±0.001 mSv/y, which is insignificant in comparison with the values of the doses from the top of the atmosphere.

  12. Human skin equivalent as an alternative to animal testing.

    Science.gov (United States)

    Mertsching, Heike; Weimer, Michaela; Kersen, Silke; Brunner, Herwig

    2008-03-11

    The 3-D skin equivalent can be viewed as physiologically comparable to the natural skin and therefore is a suitable alternative for animal testing. This highly differentiated in vitro human skin equivalent is used to assess the efficacy and mode of action of novel agents. This model is generated from primary human keratinocytes on a collagen substrate containing human dermal fibroblasts. It is grown at the air-liquid interface which allows full epidermal stratification and epidermal-dermal interactions to occur. Future emphasis is the establishment of different test systems to investigate wound healing, melanoma research and infection biology. Key features of this skin model are that it can be used as an alternative for in vivo studies, donor tissue can be tailored to the needs of the study and multiple analyses can be carried out at mRNA and protein level. Driven by both ethical and economical incentives, this has already resulted in a shift of the test strategies used by the Pharmaceutical Industry in the early drug development process as reflected by the increased demand for application of cell based assays. It is also a suitable model for testing a wide variety of endpoints including cell viability, the release of proinflammatory mediators, permeation rate, proliferation and biochemical changes.

  13. Power curve report - with rotor equivalent wind speed

    DEFF Research Database (Denmark)

    Villanueva, Héctor; Gómez Arranz, Paula

    This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here, the refere...

  14. Affine Equivalence of Quartic Monomial Rotation Symmetric Boolean Functions in Prime Power Dimension

    Science.gov (United States)

    2015-01-27

    ANF. This representation of f (not unique, since one can choose any representative in Gn(x1xi2 . . . xil)) is called the short algebraic normal form ...Affine Equivalence of Quartic Monomial Rotation Symmetric Boolean Functions in Prime Power Dimension Pantelimon Stănică Naval Postgraduate School...Boolean functions, circulant matrices, affine equivalence , permutations, prime powers. Mathematics Subject Classification [2010]: 94A60, 94C10, 06E30 1

  15. The techniques and applications of power system dynamic equivalents at CEGB, EDF and ENEL

    Energy Technology Data Exchange (ETDEWEB)

    Caprio, U.; Barbier, C.; Humphreys, P.

    1982-12-01

    A presentation is given of the state of the art in the field of ''Dynamic Equivalents Application'' at CEGB, EDF, ENEL. While in the past years the stress was mainly put on theoretical matters related to the development of general methods for simplifying the dynamic model of multimachine systems, various results of practical application are now available. These results confirm that dynamic equivalents are a powerful tool to simplify the analysis of the dynamic performance of large power systems. Since the use of dynamic equivalents can already be considered a current practice, based on standard procedures, it is possible to gather and compare different experience. The interest in this comparison stems from the consideration that, while the technique for deriving passive equivalents is an exact process giving results as accurate as the input data, the dynamic (or active) equivalents inevitably involve some loss of accuracy which has to be justified in some way.

  16. Equivalent T cell epitope promiscuity in ecologically diverse human pathogens.

    Science.gov (United States)

    Wiens, Kirsten E; Swaminathan, Harish; Copin, Richard; Lun, Desmond S; Ernst, Joel D

    2013-01-01

    The HLA (human leukocyte antigen) molecules that present pathogen-derived epitopes to T cells are highly diverse. Correspondingly, many pathogens such as HIV evolve epitope variants in order to evade immune recognition. In contrast, another persistent human pathogen, Mycobacterium tuberculosis, has highly conserved epitope sequences. This raises the question whether there is also a difference in the ability of these pathogens' epitopes to bind diverse HLA alleles, referred to as an epitope's binding promiscuity. To address this question, we compared the in silico HLA binding promiscuity of T cell epitopes from pathogens with distinct infection strategies and outcomes of human exposure. We used computer algorithms to predict the binding affinity of experimentally-verified microbial epitope peptides to diverse HLA-DR, HLA-A and HLA-B alleles. We then analyzed binding promiscuity of epitopes derived from HIV and M. tuberculosis. We also analyzed promiscuity of epitopes from Streptococcus pyogenes, which is known to exhibit epitope diversity, and epitopes of Bacillus anthracis and Clostridium tetani toxins, as these bacteria do not depend on human hosts for their survival or replication, and their toxin antigens are highly immunogenic human vaccines. We found that B. anthracis and C. tetani epitopes were the most promiscuous of the group that we analyzed. However, there was no consistent difference or trend in promiscuity in epitopes contained in HIV, M. tuberculosis, and S. pyogenes. Our results show that human pathogens with distinct immune evasion strategies and epitope diversities exhibit equivalent levels of T cell epitope promiscuity. These results indicate that differences in epitope promiscuity do not account for the observed differences in epitope variation and conservation.

  17. Equivalent T cell epitope promiscuity in ecologically diverse human pathogens.

    Directory of Open Access Journals (Sweden)

    Kirsten E Wiens

    Full Text Available BACKGROUND: The HLA (human leukocyte antigen molecules that present pathogen-derived epitopes to T cells are highly diverse. Correspondingly, many pathogens such as HIV evolve epitope variants in order to evade immune recognition. In contrast, another persistent human pathogen, Mycobacterium tuberculosis, has highly conserved epitope sequences. This raises the question whether there is also a difference in the ability of these pathogens' epitopes to bind diverse HLA alleles, referred to as an epitope's binding promiscuity. To address this question, we compared the in silico HLA binding promiscuity of T cell epitopes from pathogens with distinct infection strategies and outcomes of human exposure. METHODS: We used computer algorithms to predict the binding affinity of experimentally-verified microbial epitope peptides to diverse HLA-DR, HLA-A and HLA-B alleles. We then analyzed binding promiscuity of epitopes derived from HIV and M. tuberculosis. We also analyzed promiscuity of epitopes from Streptococcus pyogenes, which is known to exhibit epitope diversity, and epitopes of Bacillus anthracis and Clostridium tetani toxins, as these bacteria do not depend on human hosts for their survival or replication, and their toxin antigens are highly immunogenic human vaccines. RESULTS: We found that B. anthracis and C. tetani epitopes were the most promiscuous of the group that we analyzed. However, there was no consistent difference or trend in promiscuity in epitopes contained in HIV, M. tuberculosis, and S. pyogenes. CONCLUSIONS: Our results show that human pathogens with distinct immune evasion strategies and epitope diversities exhibit equivalent levels of T cell epitope promiscuity. These results indicate that differences in epitope promiscuity do not account for the observed differences in epitope variation and conservation.

  18. Equivalent modeling of PMSG-based wind power plants considering LVRT capabilities: electromechanical transients in power systems.

    Science.gov (United States)

    Ding, Ming; Zhu, Qianlong

    2016-01-01

    Hardware protection and control action are two kinds of low voltage ride-through technical proposals widely used in a permanent magnet synchronous generator (PMSG). This paper proposes an innovative clustering concept for the equivalent modeling of a PMSG-based wind power plant (WPP), in which the impacts of both the chopper protection and the coordinated control of active and reactive powers are taken into account. First, the post-fault DC link voltage is selected as a concentrated expression of unit parameters, incoming wind and electrical distance to a fault point to reflect the transient characteristics of PMSGs. Next, we provide an effective method for calculating the post-fault DC link voltage based on the pre-fault wind energy and the terminal voltage dip. Third, PMSGs are divided into groups by analyzing the calculated DC link voltages without any clustering algorithm. Finally, PMSGs of the same group are equivalent as one rescaled PMSG to realize the transient equivalent modeling of the PMSG-based WPP. Using the DIgSILENT PowerFactory simulation platform, the efficiency and accuracy of the proposed equivalent model are tested against the traditional equivalent WPP and the detailed WPP. The simulation results show the proposed equivalent model can be used to analyze the offline electromechanical transients in power systems.

  19. Pumpless microfluidic platform for drug testing on human skin equivalents.

    Science.gov (United States)

    Abaci, Hasan Erbil; Gledhill, Karl; Guo, Zongyou; Christiano, Angela M; Shuler, Michael L

    2015-02-07

    Advances in bio-mimetic in vitro human skin models increase the efficiency of drug screening studies. In this study, we designed and developed a microfluidic platform that allows for long-term maintenance of full thickness human skin equivalents (HSE) which are comprised of both the epidermal and dermal compartments. The design is based on the physiologically relevant blood residence times in human skin tissue and allows for the establishment of an air-epidermal interface which is crucial for maturation and terminal differentiation of HSEs. The small scale of the design reduces the amount of culture medium and the number of cells required by 36 fold compared to conventional transwell cultures. Our HSE-on-a-chip platform has the capability to recirculate the medium at desired flow rates without the need for pump or external tube connections. We demonstrate that the platform can be used to maintain HSEs for three weeks with proliferating keratinocytes similar to conventional HSE cultures. Immunohistochemistry analyses show that the differentiation and localization of keratinocytes was successfully achieved, establishing all sub-layers of the epidermis after one week. Basal keratinocytes located at the epidermal-dermal interface remain in a proliferative state for three weeks. We use a transdermal transport model to show that the skin barrier function is maintained for three weeks. We also validate the capability of the HSE-on-a-chip platform to be used for drug testing purposes by examining the toxic effects of doxorubucin on skin cells and structure. Overall, the HSE-on-a-chip is a user-friendly and cost-effective in vitro platform for drug testing of candidate molecules for skin disorders.

  20. Sensitivity of MEMS microwave power sensor with the length of thermopile based on Fourier equivalent model

    Institute of Scientific and Technical Information of China (English)

    Liu Tong; Liao Xiaoping; Wang Debo

    2011-01-01

    A Fourier equivalent model is introduced to research the thermal transfer behavior of a terminatingtype MEMS microwave power sensor.The fabrication of this MEMS microwave power sensor is compatible with the GaAs MMIC process.Based on the Fourier equivalent model,the relationship between the sensitivity of a MEMS microwave power sensor and the length of thermopile is studied in particular.The power sensor is measured with an input power from 1 to 100 mW at 10 GHz,and the measurement results show that the power sensor has good input match characteristics and high linearity.The sensitivity calculated from a Fourier equivalent model is about 0.12,0.20 and 0.29 mV/mW with the length at 40,70 and 100 μm,respectively,while the sensitivity of the measurement results is about 0.10,0.22 and 0.30 mV/mW,respectively,and the differences are below 0.02 mV/mW.The sensitivity expression based on the Fourier equivalent model is verified by the measurement results.

  1. Wind Farm Dynamic Equivalence Based on the Wind Turbine Output Active Power Sequence Clustering

    Directory of Open Access Journals (Sweden)

    Zhang Ge

    2016-01-01

    Full Text Available In order to reduce the complexity of simulation model containing wind farms in the context of keeping the accuracy static, this paper put forward a kind of Dynamic Equivalence method aiming at making output characteristic of the connecting point of wind farm consistent. Based on the output power sequence of wind turbines, geometric template matching algorithm is used to obtain the characteristic of that power sequence and then Attribute Threshold Clustering Algorithm is used to classify wind turbine. In each cluster, the parameter of wind turbine is made equal according to the principle of constant power output character and then be distinguished according to AMPSO. At last, this paper takes a practical wind farm as an example and respectively simulates the conditions of fault of system side and variation of wind speed, which is used in comparing the output characteristic of detailed model and Equivalent model. Results show that the output characteristic of the connecting point of wind farm keeps consistent after equivalent and that the Clustering Algorithm can reflect the operating characteristics of the wind turbine in the whole moment of any time period. It can also be saw that Equivalent method is reasonable and effective, which has certain value in engineering application.

  2. Equivalent Method of Integrated Power Generation System of Wind, Photovoltaic and Energy Storage in Power Flow Calculation and Transient Simulation

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    The integrated power generation system of wind, photovoltaic (PV) and energy storage is composed of several wind turbines, PV units and energy storage units. The detailed model of integrated generation is not suitable for the large-scale powe.r system simulation because of the model's complexity and long computation time. An equivalent method for power flow calculation and transient simulation of the integrated generation system is proposed based on actual projects, so as to establish the foundation of such integrated system simulation and analysis.

  3. Equivalent circuit and characteristic simulation of a brushless electrically excited synchronous wind power generator

    Science.gov (United States)

    Wang, Hao; Zhang, Fengge; Guan, Tao; Yu, Siyang

    2017-09-01

    A brushless electrically excited synchronous generator (BEESG) with a hybrid rotor is a novel electrically excited synchronous generator. The BEESG proposed in this paper is composed of a conventional stator with two different sets of windings with different pole numbers, and a hybrid rotor with powerful coupling capacity. The pole number of the rotor is different from those of the stator windings. Thus, an analysis method different from that applied to conventional generators should be applied to the BEESG. In view of this problem, the equivalent circuit and electromagnetic torque expression of the BEESG are derived on the basis of electromagnetic relation of the proposed generator. The generator is simulated and tested experimentally using the established equivalent circuit model. The experimental and simulation data are then analyzed and compared. Results show the validity of the equivalent circuit model.

  4. Equivalent Modeling of DFIG-Based Wind Power Plant Considering Crowbar Protection

    Directory of Open Access Journals (Sweden)

    Qianlong Zhu

    2016-01-01

    Full Text Available Crowbar conduction has an impact on the transient characteristics of a doubly fed induction generator (DFIG in the short-circuit fault condition. But crowbar protection is seldom considered in the aggregation method for equivalent modeling of DFIG-based wind power plants (WPPs. In this paper, the relationship between the growth of postfault rotor current and the amplitude of the terminal voltage dip is studied by analyzing the rotor current characteristics of a DFIG during the fault process. Then, a terminal voltage dip criterion which can identify crowbar conduction is proposed. Considering the different grid connection structures for single DFIG and WPP, the criterion is revised and the crowbar conduction is judged depending on the revised criterion. Furthermore, an aggregation model of the WPP is established based on the division principle of crowbar conduction. Finally, the proposed equivalent WPP is simulated on a DIgSILENT PowerFactory platform and the results are compared with those of the traditional equivalent WPPs and the detailed WPP. The simulation results show the effectiveness of the method for equivalent modeling of DFIG-based WPP when crowbar protection is also taken into account.

  5. Equivalent Modeling of DFIG-Based Wind Power Plant Considering Crowbar Protection

    OpenAIRE

    Qianlong Zhu; Ming Ding; Pingping Han

    2016-01-01

    Crowbar conduction has an impact on the transient characteristics of a doubly fed induction generator (DFIG) in the short-circuit fault condition. But crowbar protection is seldom considered in the aggregation method for equivalent modeling of DFIG-based wind power plants (WPPs). In this paper, the relationship between the growth of postfault rotor current and the amplitude of the terminal voltage dip is studied by analyzing the rotor current characteristics of a DFIG during the fault process...

  6. Calculation Metho d of Power Law Fluid Equivalent Permeability Considering Capillary Shap e

    Institute of Scientific and Technical Information of China (English)

    YANG Er-long; LI Huan; GAO Hui-juan; GU Ting-ting

    2015-01-01

    While studying the flow of oil and gas in the reservoir, it is not realistic that capillary with circular section is only used to express the pores. It is more representative to simulate porous media pore with kinds of capillary with triangle or rectangle section etc. In the condition of the same diameter, when polymer for oil displacement flows in the porous medium, there only exists shear flow which can be expressed with power law model. Based on fluid flow-pressure drop equation in single capillary, this paper gives a calculation method of equivalent permeability of power law fluid of single capillary and capillary bundles with different sections.

  7. The vibrational source strength descriptor using power input from equivalent forces: a simulation study

    DEFF Research Database (Denmark)

    Laugesen, Søren; Ohlrich, Mogens

    1994-01-01

    Simple, yet reliable methods for the approximate determination of the vibratory power supplied by the internal excitation forces of a given vibrational source are of great interest. One such method that relies on the application of a number of “equivalent forces” and measurements of the mean squa...... to somewhat larger estimation errors. The reliability of the estimate is also studied under different conditions with respect to coupling stiffness between source and receiver and relative mobility of the source and receiving structures......Simple, yet reliable methods for the approximate determination of the vibratory power supplied by the internal excitation forces of a given vibrational source are of great interest. One such method that relies on the application of a number of “equivalent forces” and measurements of the mean...... squared velocity on either the source or the receiving structure is studied in this paper by means of computer simulations. The study considers a simple system of two flexural beams coupled via a pair of springs. The investigation shows that a relatively small number of equivalent forces suffice...

  8. Equivalence of Optical and Electrical Noise Equivalent Power of Hybrid NbTiN-Al Microwave Kinetic Inductance Detectors

    CERN Document Server

    Janssen, R M J; de Visser, P J; Klapwijk, T M; Baselmans, J J A

    2014-01-01

    We have measured and compared the response of hybrid NbTiN-Al Microwave Kinetic Inductance Detectors (MKIDs) to changes in bath temperature and illumination by sub-mm radiation. We show that these two stimulants have an equivalent effect on the resonance feature of hybrid MKIDs. We determine an electrical NEP from the measured temperature responsivity, quasiparticle recombination time, superconducting transition temperature and noise spectrum, all of which can be measured in a dark environment. For the two hybrid NbTiN-Al MKIDs studied in detail the electrical NEP is within a factor of two of the optical NEP, which is measured directly using a blackbody source.

  9. Improving the Accuracy of Wind Turbine Power Curve Validation by the Rotor Equivalent Wind Speed Concept

    Science.gov (United States)

    Scheurich, Frank; Enevoldsen, Peder B.; Paulsen, Henrik N.; Dickow, Kristoffer K.; Fiedel, Moritz; Loeven, Alex; Antoniou, Ioannis

    2016-09-01

    The measurement of the wind speed at hub height is part of the current IEC standard procedure for the power curve validation of wind turbines. The inherent assumption is thereby made that this measured hub height wind speed sufficiently represents the wind speed across the entire rotor area. It is very questionable, however, whether the hub height wind speed (HHWS) method is appropriate for rotor sizes of commercial state-of-the-art wind turbines. The rotor equivalent wind speed (REWS) concept, in which the wind velocities are measured at several different heights across the rotor area, is deemed to be better suited to represent the wind speed in power curve measurements and thus results in more accurate predictions of the annual energy production (AEP) of the turbine. The present paper compares the estimated AEP, based on HHWS power curves, of two different commercial wind turbines to the AEP that is based on REWS power curves. The REWS was determined by LiDAR measurements of the wind velocities at ten different heights across the rotor area. It is shown that a REWS power curve can, depending on the wind shear profile, result in higher, equal or lower AEP estimations compared to the AEP predicted by a HHWS power curve.

  10. Development of a dielectric equivalent gel for better impedance matching for human skin.

    Science.gov (United States)

    Sunaga, Takahiro; Ikehira, Hiroo; Furukawa, Shigeo; Tamura, Mitsuru; Yoshitome, Eiji; Obata, Takayuki; Shinkai, Hiroshi; Tanada, Shuji; Murata, Hajime; Sasaki, Yasuhito

    2003-04-01

    It would be useful to develop a tissue equivalent gel to improve the uniformity of the electromagnetic field in the human body, and for making a tissue equivalent dielectric human phantom. In this study, solid type, water based gelatin-honey gels were developed which have the electrical characteristics of skin tissue. It was demonstrated that a stable and homogeneous gel, with a relative dielectric constant epsilon ' chosen from desired ranges found in skin, can be made for 200-400 MHz.

  11. Theoretical and practical equivalents in multimachine power systems. Part 1: Construction of coherency power systems. Part 1: Construction of coherency based theoretical equivalent

    Energy Technology Data Exchange (ETDEWEB)

    Di Caprio, U.

    1982-10-01

    Taking account of the structural conditions for theoretical coherency, a single machine equivalent circuit is determined. This is an extension of the Thevenin theorem to electromechanic circuits and will be used as the basis for constructing a practical dynamic equivalent in the second part of the paper.

  12. An Equivalent Mechanical Model for Representing the Entropy Generation in Heat Exchangers. Application to Power Cycles

    Directory of Open Access Journals (Sweden)

    Federico Ramírez

    2011-07-01

    Full Text Available

    One of the most common difficulties students face in learning Thermodynamics lies in grasping the physical meaning of concepts such as lost availability and entropy generation. This explains the quest for new approaches for explaining and comprehending these quantities, as suggested by diagrams from different authors. The difficulties worsen in the case of irreversibilities associated with heat transfer processes driven by a finite temperature difference, where no work transfer takes place. An equivalent mechanical model is proposed in this paper. Heat exchangers are modelled by means of Carnot heat engines and mechanical transmissions; the use of mechanical models allows an easy visualization of thermal irreversibilities. The proposed model is further applied to a power cycle, thus obtaining an “equivalent arrangement” where irreversibilities become clearly apparent.

  13. An equivalent circuit model and power calculations for the APS SPX crab cavities.

    Energy Technology Data Exchange (ETDEWEB)

    Berenc, T. (Accelerator Systems Division (APS))

    2012-03-21

    An equivalent parallel resistor-inductor-capacitor (RLC) circuit with beam loading for a polarized TM110 dipole-mode cavity is developed and minimum radio-frequency (rf) generator requirements are calculated for the Advanced Photon Source (APS) short-pulse x-ray (SPX) superconducting rf (SRF) crab cavities. A beam-loaded circuit model for polarized TM110 mode crab cavities was derived. The single-cavity minimum steady-state required generator power has been determined for the APS SPX crab cavities for a storage ring current of 200mA DC current as a function of external Q for various vertical offsets including beam tilt and uncontrollable detuning. Calculations to aid machine protection considerations were given.

  14. Development of human skin equivalents mimicking skin aging : contrast between papillary and reticular fibroblasts as a lead

    NARCIS (Netherlands)

    Janson, D.

    2017-01-01

    This thesis describes the development of human skin equivalents that show characteristics of skin aging. The type of skin equivalent used was a fibroblast derived matrix equivalent, in which the dermal compartment is generated by fibroblasts and thus is fully of human origin. Two strategies are

  15. New equivalent-electrical circuit model and a practical measurement method for human body impedance.

    Science.gov (United States)

    Chinen, Koyu; Kinjo, Ichiko; Zamami, Aki; Irei, Kotoyo; Nagayama, Kanako

    2015-01-01

    Human body impedance analysis is an effective tool to extract electrical information from tissues in the human body. This paper presents a new measurement method of impedance using armpit electrode and a new equivalent circuit model for the human body. The lowest impedance was measured by using an LCR meter and six electrodes including armpit electrodes. The electrical equivalent circuit model for the cell consists of resistance R and capacitance C. The R represents electrical resistance of the liquid of the inside and outside of the cell, and the C represents high frequency conductance of the cell membrane. We propose an equivalent circuit model which consists of five parallel high frequency-passing CR circuits. The proposed equivalent circuit represents alpha distribution in the impedance measured at a lower frequency range due to ion current of the outside of the cell, and beta distribution at a high frequency range due to the cell membrane and the liquid inside cell. The calculated values by using the proposed equivalent circuit model were consistent with the measured values for the human body impedance.

  16. Reconstruction of a full-thickness collagen-based human oral mucosal equivalent.

    Science.gov (United States)

    Kinikoglu, Beste; Auxenfans, Céline; Pierrillas, Pascal; Justin, Virginie; Breton, Pierre; Burillon, Carole; Hasirci, Vasif; Damour, Odile

    2009-11-01

    Tissue engineered human oral mucosa has the potential to be applied to the closure of surgical wounds after tissue deficits due to facial trauma, malignant lesion surgery or preposthetic procedure. It can also be used to elucidate the biology and pathology of oral mucosa and as a model alternative to animals for safety testing of oral care products. Using the technology previously developed in our laboratory for the production of a skin equivalent, we were able to reconstruct a nonkeratinized full-thickness human oral mucosal equivalent closely mimicking human native oral mucosa. The successive coculture of human lamina propria fibroblasts and human oral epithelial cells isolated from the nonkeratinized region of oral cavity in a porous collagen-glycosaminoglycan (GAG)-chitosan scaffold gave rise to a lamina propria equivalent (LPE) and then to an oral mucosa equivalent (OME). The results of the histology, immunohistology and transmission electron microscopy of this OME demonstrated the presence of a nonkeratinized pluristratified and differentiated epithelium as in native nonkeratinized human oral mucosa expressing both K13 and K3/76. This epithelium was firmly anchored to the LPE by a continuous and ultrastructurally well-organized basement membrane. In the LPE, fibroblasts synthesized new extracellular matrix where the average collagen fibre diameter was 28.4 nm, close to that of native oral mucosa. The proliferative capacity of the basal cells was demonstrated by the expression of Ki67.

  17. Testing the equivalence of modern human cranial covariance structure: Implications for bioarchaeological applications.

    Science.gov (United States)

    von Cramon-Taubadel, Noreen; Schroeder, Lauren

    2016-10-01

    Estimation of the variance-covariance (V/CV) structure of fragmentary bioarchaeological populations requires the use of proxy extant V/CV parameters. However, it is currently unclear whether extant human populations exhibit equivalent V/CV structures. Random skewers (RS) and hierarchical analyses of common principal components (CPC) were applied to a modern human cranial dataset. Cranial V/CV similarity was assessed globally for samples of individual populations (jackknifed method) and for pairwise population sample contrasts. The results were examined in light of potential explanatory factors for covariance difference, such as geographic region, among-group distance, and sample size. RS analyses showed that population samples exhibited highly correlated multivariate responses to selection, and that differences in RS results were primarily a consequence of differences in sample size. The CPC method yielded mixed results, depending upon the statistical criterion used to evaluate the hierarchy. The hypothesis-testing (step-up) approach was deemed problematic due to sensitivity to low statistical power and elevated Type I errors. In contrast, the model-fitting (lowest AIC) approach suggested that V/CV matrices were proportional and/or shared a large number of CPCs. Pairwise population sample CPC results were correlated with cranial distance, suggesting that population history explains some of the variability in V/CV structure among groups. The results indicate that patterns of covariance in human craniometric samples are broadly similar but not identical. These findings have important implications for choosing extant covariance matrices to use as proxy V/CV parameters in evolutionary analyses of past populations. © 2016 Wiley Periodicals, Inc.

  18. Dynamic equivalent method of interconnected power systems with consideration of motor loads

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The existing equivalent methods usually only deal with static load models and neglect the dynamic characteristics of loads such as induction motors.This paper presents a dynamic equivalent method which considers motor dynamics.At first,the clustering criterion of motor loads is given.The motors with similar dynamic characteristics are classified into one group.Then,reduction of motors in the same group is carried out.Finally,parameters of the equivalent motor are calculated and the equivalent system is thus obtained.This aggregation method is applied to the New England system of 39-buses and 10-generators.Simulation results show that the equivalent system retains the dynamic performance of the original system with good accuracy.Compared with the 1-motor equivalent scheme,the 2-motor equivalent scheme can improve equivalent precision effectively.

  19. Compact Tissue-equivalent Proportional Counter for Deep Space Human Missions.

    Science.gov (United States)

    Straume, T; Braby, L A; Borak, T B; Lusby, T; Warner, D W; Perez-Nunez, D

    2015-10-01

    Effects on human health from the complex radiation environment in deep space have not been measured and can only be simulated here on Earth using experimental systems and beams of radiations produced by accelerators, usually one beam at a time. This makes it particularly important to develop instruments that can be used on deep-space missions to measure quantities that are known to be relatable to the biological effectiveness of space radiation. Tissue-equivalent proportional counters (TEPCs) are such instruments. Unfortunately, present TEPCs are too large and power intensive to be used beyond low Earth orbit (LEO). Here, the authors describe a prototype of a compact TEPC designed for deep space applications with the capability to detect both ambient galactic cosmic rays and intense solar particle event radiation. The device employs an approach that permits real-time determination of yD (and thus quality factor) using a single detector. This was accomplished by assigning sequential sampling intervals as detectors “1” and “2” and requiring the intervals to be brief compared to the change in dose rate. Tests with g rays show that the prototype instrument maintains linear response over the wide dose-rate range expected in space with an accuracy of better than 5% for dose rates above 3 mGy h(-1). Measurements of yD for 200 MeV n(-1) carbon ions were better than 10%. Limited tests with fission spectrum neutrons show absorbed dose-rate accuracy better than 15%.

  20. Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin

    NARCIS (Netherlands)

    Eweje, M.O.

    2016-01-01

    The studies in this thesis describes the barrier defects in Atopic Dermatitis (AD) skin and various techniques to develop AD Human Skin Equivalents (HSEs) which can be used to better understand the role of several factors in the pathogenesis of AD skin. The results described show that Inflammation p

  1. Operational reliability evaluation of restructured power systems with wind power penetration utilizing reliability network equivalent and time-sequential simulation approaches

    DEFF Research Database (Denmark)

    Ding, Yi; Cheng, Lin; Zhang, Yonghong

    2014-01-01

    and reserve provides, fast reserve providers and transmission network in restructured power systems. A contingency management schema for real time operation considering its coupling with the day-ahead market is proposed. The time-sequential Monte Carlo simulation is used to model the chronological...... with high wind power penetration. The proposed technique is based on the combination of the reliability network equivalent and time-sequential simulation approaches. The operational reliability network equivalents are developed to represent reliability models of wind farms, conventional generation...... characteristics of corresponding reliability network equivalents. A simplified method is also developed in the simulation procedures for improving the computational efficiency. The proposed technique can be used to evaluate customers’ reliabilities considering high penetration of wind power during the power...

  2. Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells.

    Directory of Open Access Journals (Sweden)

    Karl Gledhill

    Full Text Available The current utility of 3D skin equivalents is limited by the fact that existing models fail to recapitulate the cellular complexity of human skin. They often contain few cell types and no appendages, in part because many cells found in the skin are difficult to isolate from intact tissue and cannot be expanded in culture. Induced pluripotent stem cells (iPSCs present an avenue by which we can overcome this issue due to their ability to be differentiated into multiple cell types in the body and their unlimited growth potential. We previously reported generation of the first human 3D skin equivalents from iPSC-derived fibroblasts and iPSC-derived keratinocytes, demonstrating that iPSCs can provide a foundation for modeling a complex human organ such as skin. Here, we have increased the complexity of this model by including additional iPSC-derived melanocytes. Epidermal melanocytes, which are largely responsible for skin pigmentation, represent the second most numerous cell type found in normal human epidermis and as such represent a logical next addition. We report efficient melanin production from iPSC-derived melanocytes and transfer within an entirely iPSC-derived epidermal-melanin unit and generation of the first functional human 3D skin equivalents made from iPSC-derived fibroblasts, keratinocytes and melanocytes.

  3. MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure.

    Science.gov (United States)

    Kosten, Ilona J; Spiekstra, Sander W; de Gruijl, Tanja D; Gibbs, Susan

    2015-08-15

    After allergen or irritant exposure, Langerhans cells (LC) undergo phenotypic changes and exit the epidermis. In this study we describe the unique ability of MUTZ-3 derived Langerhans cells (MUTZ-LC) to display similar phenotypic plasticity as their primary counterparts when incorporated into a physiologically relevant full-thickness skin equivalent model (SE-LC). We describe differences and similarities in the mechanisms regulating LC migration and plasticity upon allergen or irritant exposure. The skin equivalent consisted of a reconstructed epidermis containing primary differentiated keratinocytes and CD1a(+) MUTZ-LC on a primary fibroblast-populated dermis. Skin equivalents were exposed to a panel of allergens and irritants. Topical exposure to sub-toxic concentrations of allergens (nickel sulfate, resorcinol, cinnamaldehyde) and irritants (Triton X-100, SDS, Tween 80) resulted in LC migration out of the epidermis and into the dermis. Neutralizing antibody to CXCL12 blocked allergen-induced migration, whereas anti-CCL5 blocked irritant-induced migration. In contrast to allergen exposure, irritant exposure resulted in cells within the dermis becoming CD1a(-)/CD14(+)/CD68(+) which is characteristic of a phenotypic switch of MUTZ-LC to a macrophage-like cell in the dermis. This phenotypic switch was blocked with anti-IL-10. Mechanisms previously identified as being involved in LC activation and migration in native human skin could thus be reproduced in the in vitro constructed skin equivalent model containing functional LC. This model therefore provides a unique and relevant research tool to study human LC biology in situ under controlled in vitro conditions, and will provide a powerful tool for hazard identification, testing novel therapeutics and identifying new drug targets.

  4. Non-certainty Equivalent Adaptive Exciting Control of Multi-machine Power Systems

    OpenAIRE

    2013-01-01

    Transient stability problem for multi-machine infinite bus system with the generator excitation was addressed via the non-certainty equivalent nonlinear re-parameterization method. The system need not to be linearized. The damping coefficient uncertainty was considered. A non-certainty equivalent excitation controller and a novel parameter updating law were obtained simultaneously via adaptive backstepping and Lyapunov methods to achieve stability of the error systems. Simulation results show...

  5. Programs for Optimization of Load Distribution between Power Plants and Calculation of Equivalent Energy Characteristics of Beryozovskaya GRES

    Directory of Open Access Journals (Sweden)

    V. Shcherbich

    2013-01-01

    Full Text Available The paper presents information on elaboration of algorithms and programs for intra-station optimization of load distribution between power plants and calculation of equivalent energy characteristics the Berezovskaya GRES which is one of the components of the system for optimum load distribution between thermal power plants (TPP of the Belarusian power system. Description of the accepted technical concepts, algorithm and program structures, composition and methods for input-output data, organization of personnel work with programs of load optimization has been given in the paper.

  6. Detailed Equivalent VSC-HVDC Modelling for Time Domain Harmonic Stability Studies in Wind Power Plants

    DEFF Research Database (Denmark)

    Glasdam, Jakob Bærholm; Bak, Claus Leth; Kocewiak, Lukasz Hubert;

    2017-01-01

    This paper presents a detailed equivalent modelling approach of the modular multi-level cascaded converter (MMCC) voltage source converter high voltage direct current (VSC-HVDC) in electromagnetic transient programs (EMTPs). The presented MMCC model will be evaluated based on comparison with the ......This paper presents a detailed equivalent modelling approach of the modular multi-level cascaded converter (MMCC) voltage source converter high voltage direct current (VSC-HVDC) in electromagnetic transient programs (EMTPs). The presented MMCC model will be evaluated based on comparison...... generators in service, as this is known to influence the harmonic stability in OWPPs. The paper demonstrates the necessity of the inclusion of a detailed equivalent model of the HVDC converter for harmonic stability studies in the time domain. By implementation of active filtering in the converters...

  7. Asynchronous replication and autosome-pair non-equivalence in human embryonic stem cells.

    Directory of Open Access Journals (Sweden)

    Devkanya Dutta

    Full Text Available A number of mammalian genes exhibit the unusual properties of random monoallelic expression and random asynchronous replication. Such exceptional genes include genes subject to X inactivation and autosomal genes including odorant receptors, immunoglobulins, interleukins, pheromone receptors, and p120 catenin. In differentiated cells, random asynchronous replication of interspersed autosomal genes is coordinated at the whole chromosome level, indicative of chromosome-pair non-equivalence. Here we have investigated the replication pattern of the random asynchronously replicating genes in undifferentiated human embryonic stem cells, using fluorescence in situ hybridization based assay. We show that allele-specific replication of X-linked genes and random monoallelic autosomal genes occur in human embryonic stem cells. The direction of replication is coordinated at the whole chromosome level and can cross the centromere, indicating the existence of autosome-pair non-equivalence in human embryonic stem cells. These results suggest that epigenetic mechanism(s that randomly distinguish between two parental alleles are emerging in the cells of the inner cell mass, the source of human embryonic stem cells.

  8. MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure

    Energy Technology Data Exchange (ETDEWEB)

    Kosten, Ilona J.; Spiekstra, Sander W. [Department of Dermatology, VU University Medical Center, Amsterdam (Netherlands); Gruijl, Tanja D. de [Department of Dermatology Medical Oncology, VU University Medical Center, Amsterdam (Netherlands); Gibbs, Susan, E-mail: s.gibbs@acta.nl [Department of Dermatology, VU University Medical Center, Amsterdam (Netherlands); Department of Oral Cell Biology, Academic Center for Dentistry (ACTA), Amsterdam (Netherlands)

    2015-08-15

    After allergen or irritant exposure, Langerhans cells (LC) undergo phenotypic changes and exit the epidermis. In this study we describe the unique ability of MUTZ-3 derived Langerhans cells (MUTZ-LC) to display similar phenotypic plasticity as their primary counterparts when incorporated into a physiologically relevant full-thickness skin equivalent model (SE-LC). We describe differences and similarities in the mechanisms regulating LC migration and plasticity upon allergen or irritant exposure. The skin equivalent consisted of a reconstructed epidermis containing primary differentiated keratinocytes and CD1a{sup +} MUTZ-LC on a primary fibroblast-populated dermis. Skin equivalents were exposed to a panel of allergens and irritants. Topical exposure to sub-toxic concentrations of allergens (nickel sulfate, resorcinol, cinnamaldehyde) and irritants (Triton X-100, SDS, Tween 80) resulted in LC migration out of the epidermis and into the dermis. Neutralizing antibody to CXCL12 blocked allergen-induced migration, whereas anti-CCL5 blocked irritant-induced migration. In contrast to allergen exposure, irritant exposure resulted in cells within the dermis becoming CD1a{sup −}/CD14{sup +}/CD68{sup +} which is characteristic of a phenotypic switch of MUTZ-LC to a macrophage-like cell in the dermis. This phenotypic switch was blocked with anti-IL-10. Mechanisms previously identified as being involved in LC activation and migration in native human skin could thus be reproduced in the in vitro constructed skin equivalent model containing functional LC. This model therefore provides a unique and relevant research tool to study human LC biology in situ under controlled in vitro conditions, and will provide a powerful tool for hazard identification, testing novel therapeutics and identifying new drug targets. - Highlights: • MUTZ-3 derived Langerhans cells integrated into skin equivalents are fully functional. • Anti-CXCL12 blocks allergen-induced MUTZ-LC migration.

  9. Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents.

    Science.gov (United States)

    Thakoersing, Varsha S; van Smeden, Jeroen; Mulder, Aat A; Vreeken, Rob J; El Ghalbzouri, Abdoelwaheb; Bouwstra, Joke A

    2013-01-01

    Previous results showed that our in-house human skin equivalents (HSEs) differ in their stratum corneum (SC) lipid organization compared with human SC. To elucidate the cause of the altered SC lipid organization in the HSEs, a recently developed liquid chromatography/mass spectrometry method was used to study the free fatty acid (FFA) and ceramide composition in detail. In addition, the SC lipid composition of the HSEs and human skin was examined quantitatively with high-performance thin-layer chromatography. Our results reveal that all our HSEs have an increased presence of monounsaturated FFAs compared with human SC. Moreover, the HSEs display the presence of ceramide species with a monounsaturated acyl chain, which are not detected in human SC. All HSEs also exhibit an altered expression of stearoyl-CoA desaturase, the enzyme that converts saturated FFAs to monounsaturated FFAs. Furthermore, the HSEs show the presence of 12 ceramide subclasses, similar to native human SC. However, the HSEs have increased levels of ceramides EOS and EOH and ceramide species with short total carbon chains and a reduced FFA level compared with human SC. The presence of unsaturated lipid chains in HSE offers new opportunities to mimic the lipid properties of human SC more closely.

  10. Acids with an equivalent taste lead to different erosion of human dental enamel.

    Science.gov (United States)

    Beyer, Markus; Reichert, Jörg; Bossert, Jörg; Sigusch, Bernd W; Watts, David C; Jandt, Klaus D

    2011-10-01

    The consumption of acidic soft drinks may lead to demineralization and softening of human dental enamel, known as dental erosion. The aims of this in vitro study were to determine: (i) if different acids with a similar sensorial acidic taste lead to different hardness loss of enamel and (ii) if the fruit acids tartaric, malic, lactic or ascorbic acid lead to less hardness loss of enamel than citric or phosphoric acid when their concentration in solution is based on an equivalent sensorial acidic taste. Enamel samples of non-erupted human third molars were treated with acidic solutions of tartaric (TA), malic (MA), lactic (LA), ascorbic (AA), phosphoric (PA) and citric (CA) acids with a concentration that gave an equivalent sensorial acidic taste. The acidic solutions were characterized by pH value and titratable acidity. Atomic force microscopy (AFM) based nanoindentation was used to study the nano mechanical properties and scanning electron microscopy (SEM) was used to study the morphology of the treated enamel samples and the untreated control areas, respectively. The investigated acids fell into two groups. The nano hardnesses of MA, TA and CA treated enamel samples (group I) were statistically significantly greater (penamel samples (group II). Within each group the nano hardness was not statistically significantly different (p>0.05). The SEM micrographs showed different etch prism morphologies depending on the acid used. In vitro, the acids investigated led to different erosion effects on human dental enamel, despite their equivalent sensorial acidic taste. This has not been reported previously. Copyright © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  11. Production of an acellular matrix from amniotic membrane for the synthesis of a human skin equivalent.

    Science.gov (United States)

    Sanluis-Verdes, Anahí; Yebra-Pimentel Vilar, Maria Teresa; García-Barreiro, Juan Javier; García-Camba, Marta; Ibáñez, Jacinto Sánchez; Doménech, Nieves; Rendal-Vázquez, Maria Esther

    2015-09-01

    Human amniotic membrane (HAM) has useful properties as a dermal matrix substitute. The objective of our work was to obtain, using different enzymatic or chemical treatments to eliminate cells, a scaffold of acellular HAM for later use as a support for the development of a skin equivalent. The HAM was separated from the chorion, incubated and cryopreserved. The membrane underwent different enzymatic and chemical treatments to eliminate the cells. Fibroblasts and keratinocytes were separately obtained from skin biopsies of patients following a sequential double digestion with first collagenase and then trypsin-EDTA (T/E). A skin equivalent was then constructed by seeding keratinocytes on the epithelial side and fibroblasts on the chorionic side of the decellularizated HAM. Histological, immunohistochemical, inmunofluorescent and molecular biology studies were performed. Treatment with 1% T/E at 37 °C for 30 min totally removed epithelial and mesenchymal cells. The HAM thus treated proved to be a good matrix to support adherence of cells and allowed the achievement of an integral and intact scaffold for development of a skin equivalent, which could be useful as a skin substitute for clinical use.

  12. Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin

    OpenAIRE

    Eweje, M.O.

    2016-01-01

    The studies in this thesis describes the barrier defects in Atopic Dermatitis (AD) skin and various techniques to develop AD Human Skin Equivalents (HSEs) which can be used to better understand the role of several factors in the pathogenesis of AD skin. The results described show that Inflammation plays a pivotal role in the development of epidermal and SC features of AD skin and that AD epidermal features can be maintained in vitro when AD skin biopsies are used to generate explant-HSEs. The...

  13. Tribological behaviour of skin equivalents and ex-vivo human skin against the material components of artificial turf in sliding

    NARCIS (Netherlands)

    Morales Hurtado, Marina; Peppelman, P.; Zeng, Xiangqiong; van Erp, P.E.J.; van der Heide, Emile

    2016-01-01

    This research aims to analyse the interaction of three artificial skin equivalents and human skin against the main material components of artificial turf. The tribological performance of Lorica, Silicone Skin L7350 and a recently developed Epidermal Skin Equivalent (ESE) were studied and compared to

  14. Unraveling barrier properties of three different in-house human skin equivalents.

    Science.gov (United States)

    Thakoersing, Varsha S; Gooris, Gerrit S; Mulder, Aat; Rietveld, Marion; El Ghalbzouri, Abdoelwaheb; Bouwstra, Joke A

    2012-01-01

    Human skin equivalents (HSEs) are three-dimensional culture models that are used as a model for native human skin. In this study the barrier properties of two novel HSEs, the fibroblast-derived matrix model (FDM) and the Leiden epidermal model (LEM), were compared with the full-thickness collagen model (FTM) and human skin. Since the main skin barrier is located in the lipid regions of the upper layer of the skin, the stratum corneum (SC), we investigated the epidermal morphology, expression of differentiation markers, SC permeability, lipid composition, and lipid organization of all HSEs and native human skin. Our results demonstrate that the barrier function of the FDM and LEM improved compared with that of the FTM, but all HSEs are more permeable than human skin. Further, the FDM and LEM have a relatively lower free fatty acid content than the FTM and human skin. Several similarities between the FDM, LEM and FTM were observed: (1) the morphology and the expression of the investigated differentiation markers were similar to those observed in native human skin, except for the observed expression of keratin 16 and premature expression of involucrin that were detected in all HSEs, (2) the lipids in the SC of all HSEs were arranged in lipid lamellae, similar to human skin, but show an increase in the number of lipid lamellae in the intercellular regions and (3) the SC lipids of all HSEs show a less densely packed lateral lipid organization compared with human SC. These findings indicate that the HSEs mimic many aspects of native human skin, but differ in their barrier properties.

  15. Analysis of frequency response of high power MUTC photodiodes based on photocurrent-dependent equivalent circuit model.

    Science.gov (United States)

    Li, Jin; Xiong, Bing; Sun, Changzheng; Miao, Di; Luo, Yi

    2015-08-24

    A back-illuminated mesa-structure InGaAs/InP modified uni-traveling-carrier photodiode (MUTC-PD) is fabricated and its frequency response is investigated. A bandwidth of 40 GHz and a saturation photocurrent up to 33 mA are demonstrated. A photocurrent-dependent equivalent circuit model is proposed to analyze the frequency response of the high power MUTC-PDs. The influences of the space-charge screening, self-induced electric field and over-shoot effects are discussed in detail based on the model. Fitted curves obtained from the simple equivalent circuit model are found to be in good agreement with the data measured under different bias voltages and photocurrents.

  16. The collective dose equivalent in evaluated region of bone-coal power stations and bone-coal shafts

    Institute of Scientific and Technical Information of China (English)

    ZHANG Liang; JIANG Shan; KONG Ling-Li; LI Ying; YE Ji-Da; SHI Jin-Hua; WU Zong-Mei

    2005-01-01

    During 1991-1993, the radioactivity levels of the bone-coal mines were investigated in Hubei, Hunan, Jiangxi, Zhejiang and Anhui Provinces, respectively, where the reserve of bone-coal is about 90% of our country's total reserve. The annual additional collective dose equivalent within 80km evaluated region of bone-coal power stations in Nijiangkou and Anren is 1.7 and 1.9 man .mSv,respectively,and that of Zhuantanyan bone-coal shaft is 1.4 man.mSv.The collective dose equivalent caused by bone-coal cinder brick produced for 25 years in the provinces is 1.6×105 man.Sv.

  17. A comprehensive equivalent circuit model of all-vanadium redox flow battery for power system analysis

    Science.gov (United States)

    Zhang, Yu; Zhao, Jiyun; Wang, Peng; Skyllas-Kazacos, Maria; Xiong, Binyu; Badrinarayanan, Rajagopalan

    2015-09-01

    Electrical equivalent circuit models demonstrate excellent adaptability and simplicity in predicting the electrical dynamic response of the all-vanadium redox flow battery (VRB) system. However, only a few publications that focus on this topic are available. The paper presents a comprehensive equivalent circuit model of VRB for system level analysis. The least square method is used to identify both steady-state and dynamic characteristics of VRB. The inherent features of the flow battery such as shunt current, ion diffusion and pumping energy consumption are also considered. The proposed model consists of an open-circuit voltage source, two parasitic shunt bypass circuits, a 1st order resistor-capacitor network and a hydraulic circuit model. Validated with experimental data, the proposed model demonstrates excellent accuracy. The mean-error of terminal voltage and pump consumption are 0.09 V and 0.49 W respectively. Based on the proposed model, self-discharge and system efficiency are studied. An optimal flow rate which maximizes the system efficiency is identified. Finally, the dynamic responses of the proposed VRB model under step current profiles are presented. Variables such as SOC and stack terminal voltage can be provided.

  18. Power Allocation based on Certain Equivalent Margin Applicable to Wireless Communication Systems Limited by Interference

    Directory of Open Access Journals (Sweden)

    Tadeu Junior Gross

    2015-10-01

    Full Text Available This paper analyzes the method of power allocation for wireless communication networks, limited by multiple access interference under fading Rayleigh channels. The method takes into account the statistical variation of the desired and interfering signals power and optimally and dynamically allocates the power resources in the system. This allocation is made being taken into account the restrictions imposed by the outage probability for each receiver/transmitter pair. Based on the Perron-Frobenius eigenvalue and geometric programming (GP theories, some interesting results were found for the optimization problem analyzed. A GP is a special type of optimization problem that can be transformed in a non-linear convex optimization problem simply by the change of variables, and then to be globally solved. Also, an iterative method for fast convergence was shown to find the optimally power allocation seeking to minimize the outage probability in the communication.

  19. Wind Parks equivalent ARX models for the simulation of power systems with large wind power penetration, using system-identification theory

    Energy Technology Data Exchange (ETDEWEB)

    Kanellos, F.D. [Power Systems Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens 9, Iroon Polytecheniou Street, 157 72, Zografou Campus, Athens (Greece); Hellenic Transmission System Operator, 72, Kastoros, 18545 Athens (Greece); Tsekouras, G.J. [Department of Electrical Engineering and Computer Science, Hellenic Naval Academy, Terma Hatzikiriaku, 18539 Piraeus (Greece); Hatziargyriou, N.D. [Power Systems Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens 9, Iroon Polytecheniou Street, 157 72, Zografou Campus, Athens (Greece)

    2011-02-15

    In this paper models of Wind Parks (WPs) appropriate for simulation purposes of large power systems with high wind power penetration are developed. The proposed models of the WPs are developed using system identification theory. Data obtained from the simulation of detailed WP models are used for system identification. The obtained models are general and they can be applied to different configurations of WPs as only system's input/output data are used and not any internal states of the model. Simulation results confirm the accuracy and the advantages of the proposed WP equivalent models. (author)

  20. Characterization of radiated electromagnetic fields using equivalent sources - Application to the EMC of power printed circuit boards

    Science.gov (United States)

    Beghou, Lotfi; Pichon, Lionel; Costa, François

    2009-01-01

    This article presents an original methodology to characterize electromagnetic disturbances radiated from power electronic devices. The method is based on the substitution of the power device by an equivalent set of elemental dipoles (electric and magnetic dipoles). The set of dipoles radiates the same near-field. The dipoles are determined from a near field cartography of the fields obtained with a measurement bench. The dipoles parameters are determined by solving an inverse problem using a genetic algorithm. The efficiency of the approach is demonstrated on an academic DC-DC converter. Finally some results about the chopper are presented. The methodology has two advantages: first it allows one to define some threshold limitations for electromagnetic fields on the surroundings and secondly it gives the location of the real source distribution. To cite this article: L. Beghou et al., C. R. Physique 10 (2009).

  1. Power factor compensation with lossless linear filters is equivalent to (weighted) power equalization and a new cyclo–dissipativity characterization

    NARCIS (Netherlands)

    Puerto-Flores, Dunstano del; Ortega, Romeo; Scherpen, Jacquelien M.A.

    2009-01-01

    Recently, it has been established that the problem of power factor compensation for nonlinear loads with non-sinusoidal source voltage can be recast in terms of the property of cyclo–dissipativity. Using this framework the classical capacitor and inductor compensators can be interpreted in terms of

  2. Replacement of animal-derived collagen matrix by human fibroblast-derived dermal matrix for human skin equivalent products.

    Science.gov (United States)

    El Ghalbzouri, Abdoelwaheb; Commandeur, Suzan; Rietveld, Marion H; Mulder, Aat A; Willemze, Rein

    2009-01-01

    Reconstructed human skin equivalents (HSEs) are representative models of human skin and widely used for research purposes and clinical applications. Traditional methods to generate HSEs are based on the seeding of human keratinocytes onto three-dimensional human fibroblast-populated non-human collagen matrices. Current HSEs have a limited lifespan of approximately 8 weeks, rendering them unsuitable for long-term studies. Here we present a new generation of HSEs being fully composed of human components and which can be cultured up to 20 weeks. This model is generated on a primary human fibroblast-derived dermal matrix. Pro-collagen type I secretion by human fibroblasts stabilized during long-term culture, providing a continuous and functional human dermal matrix. In contrast to rat-tail collagen-based HSEs, the present fibroblast-derived matrix-based HSEs contain more continuity in the number of viable cell layers in long-term cultures. In addition, these new skin models exhibit normal differentiation and proliferation, based on expression of K10/K15, and K16/K17, respectively. Detection of collagen types IV and VII and laminin 332 was confined to the epidermal-dermal junction, as in native skin. The presence of hemidesmosomes and anchoring fibrils was demonstrated by electron microscopy. Finally, we show that the presented HSE contained a higher concentration of the normal moisturizing factor compared to rat-tail collagen-based skin models, providing a further representation of functional normal human skin in vitro. This study, therefore, demonstrates the role of the dermal microenvironment on epidermal regeneration and lifespan in vitro.

  3. Development of a full-thickness human skin equivalent in vitro model derived from TERT-immortalized keratinocytes and fibroblasts

    NARCIS (Netherlands)

    C.M.A. Reijnders; A. van Lier; S. Roffel; D. Kramer; R.J. Scheper; S. Gibbs

    2015-01-01

    Currently, human skin equivalents (HSEs) used for in vitro assays (e.g., for wound healing) make use of primary human skin cells. Limitations of primary keratinocytes and fibroblasts include availability of donor skin and donor variation. The use of physiologically relevant cell lines could solve th

  4. Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts

    NARCIS (Netherlands)

    Reijnders, Christianne M. A.; van Lier, Amanda; Roffel, Sanne; Kramer, Duco; Scheper, Rik J.; Gibbs, Susan

    2015-01-01

    Currently, human skin equivalents (HSEs) used for in vitro assays (e.g., for wound healing) make use of primary human skin cells. Limitations of primary keratinocytes and fibroblasts include availability of donor skin and donor variation. The use of physiologically relevant cell lines could solve th

  5. Equivalent dynamical complexity in a many-body quantum and collective human system

    Directory of Open Access Journals (Sweden)

    Neil F. Johnson

    2011-03-01

    Full Text Available Proponents of Complexity Science believe that the huge variety of emergent phenomena observed throughout nature, are generated by relatively few microscopic mechanisms. Skeptics however point to the lack of concrete examples in which a single mechanistic model manages to capture relevant macroscopic and microscopic properties for two or more distinct systems operating across radically different length and time scales. Here we show how a single complexity model built around cluster coalescence and fragmentation, can cross the fundamental divide between many-body quantum physics and social science. It simultaneously (i explains a mysterious recent finding of Fratini et al. concerning quantum many-body effects in cuprate superconductors (i.e. scale of 10−9 − 10−4 meters and 10−12 − 10−6 seconds, (ii explains the apparent universality of the casualty distributions in distinct human insurgencies and terrorism (i.e. scale of 103 − 106 meters and 104 − 108 seconds, (iii shows consistency with various established empirical facts for financial markets, neurons and human gangs and (iv makes microscopic sense for each application. Our findings also suggest that a potentially productive shift can be made in Complexity research toward the identification of equivalent many-body dynamics in both classical and quantum regimes.

  6. Allometric scaling of dietary linoleic acid on changes in tissue arachidonic acid using human equivalent diets in mice

    Directory of Open Access Journals (Sweden)

    Whelan Jay

    2011-06-01

    Full Text Available Abstract Background It is hypothesized that dietary linoleic acid (LA promotes chronic and acute diseases in humans by enriching tissues with arachidonic acid (AA, its downstream metabolite, and dietary studies with rodents have been useful for validation. However, levels of LA in research diets of rodents, as published in the literature, are notoriously erratic making interspecies comparisons unreliable. Therefore, the ability to extrapolate the biological effects of dietary LA from experimental rodents to humans necessitates an allometric scaling model that is rooted within a human equivalent context. Methods To determine the physiological response of dietary LA on tissue AA, a mathematical model for extrapolating nutrients based on energy was used, as opposed to differences in body weight. C57BL/6J mice were divided into 9 groups fed a background diet equivalent to that of the US diet (% energy with supplemental doses of LA or AA. Changes in the phospholipid fatty acid compositions were monitored in plasma and erythrocytes and compared to data from humans supplemented with equivalent doses of LA or AA. Results Increasing dietary LA had little effect on tissue AA, while supplementing diets with AA significantly increased tissue AA levels, importantly recapitulating results from human trials. Conclusions Thus, interspecies comparisons for dietary LA between rodents and humans can be achieved when rodents are provided human equivalent doses based on differences in metabolic activity as defined by energy consumption.

  7. Power-law regularities in human language

    Science.gov (United States)

    Mehri, Ali; Lashkari, Sahar Mohammadpour

    2016-11-01

    Complex structure of human language enables us to exchange very complicated information. This communication system obeys some common nonlinear statistical regularities. We investigate four important long-range features of human language. We perform our calculations for adopted works of seven famous litterateurs. Zipf's law and Heaps' law, which imply well-known power-law behaviors, are established in human language, showing a qualitative inverse relation with each other. Furthermore, the informational content associated with the words ordering, is measured by using an entropic metric. We also calculate fractal dimension of words in the text by using box counting method. The fractal dimension of each word, that is a positive value less than or equal to one, exhibits its spatial distribution in the text. Generally, we can claim that the Human language follows the mentioned power-law regularities. Power-law relations imply the existence of long-range correlations between the word types, to convey an especial idea.

  8. A reconsideration of the noise equivalent power and the data analysis procedure for the infrared imaging video bolometers.

    Science.gov (United States)

    Pandya, Shwetang N; Peterson, Byron J; Kobayashi, Masahiro; Pandya, Santosh P; Mukai, Kiyofumi; Sano, Ryuichi

    2014-12-01

    The infrared imaging video bolometer (IRVB) used for measurement of the two-dimensional (2D) radiation profiles from the Large Helical Device has been significantly upgraded recently to improve its signal to noise ratio, sensitivity, and calibration, which ultimately provides quantitative measurements of the radiation from the plasma. The reliability of the quantified data needs to be established by various checks. The noise estimates also need to be revised and more realistic values need to be established. It is shown that the 2D heat diffusion equation can be used for estimating the power falling on the IRVB foil, even with a significant amount of spatial variation in the thermal diffusivity across the area of the platinum foil found experimentally during foil calibration. The equation for the noise equivalent power density (NEPD) is re-derived to include the errors in the measurement of the thermophysical and the optical properties of the IRVB foil. The theoretical value estimated using this newly derived equation matches closely, within 5.5%, with the mean experimental value. The change in the contribution of each error term of the NEPD equation with rising foil temperature is also studied and the blackbody term is found to dominate the other terms at elevated operating temperatures. The IRVB foil is also sensitive to the charge exchange (CX) neutrals escaping from the plasma. The CX neutral contribution is estimated to be marginally higher than the noise equivalent power (NEP) of the IRVB. It is also established that the radiation measured by the IRVB originates from the impurity line radiation from the plasma and not from the heated divertor tiles. The change in the power density due to noise reduction measures such as data smoothing and averaging is found to be comparable to the IRVB NEPD. The precautions that need to be considered during background subtraction are also discussed with experimental illustrations. Finally, the analysis algorithm with all the

  9. Analysis and application of equivalents in power systems; Analisis y aplicacion de equivalentes en sistemas de potencia

    Energy Technology Data Exchange (ETDEWEB)

    Salinas Barrera, Humberto

    1987-09-01

    The main objective of this thesis is to present a network reduction model that can be used in the simulation of diverse phenomena that occur in the operation of the electric power systems (EPS). The work shows the development and the application of the equivalent in studies of: power flows in steady state, transient stability, generalized dynamic behavior and simplified frequency behavior. This model arises as a result of the EPS behavior observation and analysis, separating loads, generations, electric networks and its elements in derivation, effects. The algorithm uses an alternative approach to the equivalent's traditional presentation, where the loads are weighed in the process of elimination of their neighboring nodes, based on a vectorial reduction of the lines or transformers that become involved in the eliminated node. Similarly the effects of the elements are transferred to the derived elements. The results thus obtained have a small maladjustment in reactive power, becoming then necessary to compensate the reduced base case. The compensation is only necessary in the nodes that were neighbors to one that was eliminated during the process, and this compensation is made considering the branches that finally resulted connected to such node. The algorithm utilizes the obtained voltages in the original base case to calculate the output complex potencies of each one of the branches connected to the compensated node. The summation of the resulting potencies are the adjustments to the reduced base case. The proposed model of equivalents allows the analysis of contingencies in points where the traditional equivalents do not allow it, because of losing the sensibility in bringing close together the contingencies to the equivalent, the method allows analyzing any contingency in the center of the equivalent without concerning their proximity to the external area, inclusively contingencies in the center of the equivalent can be studied. The equivalent proposed was

  10. Human Mars Surface Mission Nuclear Power Considerations

    Science.gov (United States)

    Rucker, Michelle A.

    2018-01-01

    A key decision facing Mars mission designers is how to power a crewed surface field station. Unlike the solar-powered Mars Exploration Rovers (MER) that could retreat to a very low power state during a Martian dust storm, human Mars surface missions are estimated to need at least 15 kilowatts of electrical (kWe) power simply to maintain critical life support and spacecraft functions. 'Hotel' loads alone for a pressurized crew rover approach two kWe; driving requires another five kWe-well beyond what the Curiosity rover’s Radioisotope Power System (RPS) was designed to deliver. Full operation of a four-crew Mars field station is estimated at about 40 kWe. Clearly, a crewed Mars field station will require a substantial and reliable power source, beyond the scale of robotic mission experience. This paper explores the applications for both fission and RPS nuclear options for Mars.

  11. Exploring human inactivity in computer power consumption

    Science.gov (United States)

    Candrawati, Ria; Hashim, Nor Laily Binti

    2016-08-01

    Managing computer power consumption has become an important challenge in computer society and this is consistent with a trend where a computer system is more important to modern life together with a request for increased computing power and functions continuously. Unfortunately, previous approaches are still inadequately designed to handle the power consumption problem due to unpredictable workload of a system caused by unpredictable human behaviors. This is happens due to lack of knowledge in a software system and the software self-adaptation is one approach in dealing with this source of uncertainty. Human inactivity is handled by adapting the behavioral changes of the users. This paper observes human inactivity in the computer usage and finds that computer power usage can be reduced if the idle period can be intelligently sensed from the user activities. This study introduces Control, Learn and Knowledge model that adapts the Monitor, Analyze, Planning, Execute control loop integrates with Q Learning algorithm to learn human inactivity period to minimize the computer power consumption. An experiment to evaluate this model was conducted using three case studies with same activities. The result show that the proposed model obtained those 5 out of 12 activities shows the power decreasing compared to others.

  12. Estimation of Downtime and of Missed Energy Associated with a Wave Energy Converter by the Equivalent Power Storm Model

    Directory of Open Access Journals (Sweden)

    Felice Arena

    2015-10-01

    Full Text Available The design of any wave energy converter involves the determination of relevant statistical data on the wave energy resource oriented to the evaluation of the structural reliability and energy performance of the device. Currently, limited discussions concern the estimation of parameters connected to the energy performance of a device. Thus, this paper proposes a methodology for determining average downtime and average missed energy, which is the energy that is not harvested because of device deactivations during severe sea storms. These quantities are fundamental for evaluating the expected inactivity of a device during a year or during its lifetime and are relevant for assessing the effectiveness of a device working at a certain site. For this purpose, the equivalent power storm method is used for their derivation, starting from concepts pertaining to long-term statistical analysis. The paper shows that the proposed solutions provide reliable estimations via comparison with results obtained by processing long wave data.

  13. Mechanical Stretch on Human Skin Equivalents Increases the Epidermal Thickness and Develops the Basement Membrane.

    Directory of Open Access Journals (Sweden)

    Eijiro Tokuyama

    Full Text Available All previous reports concerning the effect of stretch on cultured skin cells dealt with experiments on epidermal keratinocytes or dermal fibroblasts alone. The aim of the present study was to develop a system that allows application of stretch stimuli to human skin equivalents (HSEs, prepared by coculturing of these two types of cells. In addition, this study aimed to analyze the effect of a stretch on keratinization of the epidermis and on the basement membrane. HSEs were prepared in a gutter-like structure created with a porous silicone sheet in a silicone chamber. After 5-day stimulation with stretching, HSEs were analyzed histologically and immunohistologically. Stretch-stimulated HSEs had a thicker epidermal layer and expressed significantly greater levels of laminin 5 and collagen IV/VII in the basal layer compared with HSEs not subjected to stretch stimulation. Transmission electron microscopy revealed that the structure of the basement membrane was more developed in HSEs subjected to stretching. Our model may be relevant for extrapolating the effect of a stretch on the skin in a state similar to an in vivo system. This experimental system may be useful for analysis of the effects of stretch stimuli on skin properties and wound healing and is also expected to be applicable to an in vitro model of a hypertrophic scar in the future.

  14. Development of a Full-Thickness Human Gingiva Equivalent Constructed from Immortalized Keratinocytes and Fibroblasts.

    Science.gov (United States)

    Buskermolen, Jeroen K; Reijnders, Christianne M A; Spiekstra, Sander W; Steinberg, Thorsten; Kleverlaan, Cornelis J; Feilzer, Albert J; Bakker, Astrid D; Gibbs, Susan

    2016-08-01

    Organotypic models make it possible to investigate the unique properties of oral mucosa in vitro. For gingiva, the use of human primary keratinocytes (KC) and fibroblasts (Fib) is limited due to the availability and size of donor biopsies. The use of physiologically relevant immortalized cell lines would solve these problems. The aim of this study was to develop fully differentiated human gingiva equivalents (GE) constructed entirely from cell lines, to compare them with the primary cell counterpart (Prim), and to test relevance in an in vitro wound healing assay. Reconstructed gingiva epithelium on a gingiva fibroblast-populated collagen hydrogel was constructed from cell lines (keratinocytes: TERT or HPV immortalized; fibroblasts: TERT immortalized) and compared to GE-Prim and native gingiva. GE were characterized by immunohistochemical staining for proliferation (Ki67), epithelial differentiation (K10, K13), and basement membrane (collagen type IV and laminin 5). To test functionality of GE-TERT, full-thickness wounds were introduced. Reepithelialization, fibroblast repopulation of hydrogel, metabolic activity (MTT assay), and (pro-)inflammatory cytokine release (enzyme-linked immunosorbent assay) were assessed during wound closure over 7 days. Significant differences in basal KC cytokine secretion (IL-1α, IL-18, and CXCL8) were only observed between KC-Prim and KC-HPV. When Fib-Prim and Fib-TERT were stimulated with TNF-α, no differences were observed regarding cytokine secretion (IL-6, CXCL8, and CCL2). GE-TERT histology, keratin, and basement membrane protein expression very closely represented native gingiva and GE-Prim. In contrast, the epithelium of GE made with HPV-immortalized KC was disorganized, showing suprabasal proliferating cells, limited keratinocyte differentiation, and the absence of basement membrane proteins. When a wound was introduced into the more physiologically relevant GE-TERT model, an immediate inflammatory response (IL-6, CCL2, and

  15. Basement membrane reconstruction in human skin equivalents is regulated by fibroblasts and/or exogenously activated keratinocytes

    NARCIS (Netherlands)

    El Ghalbzouri, A; Jonkman, MF; Dijkman, R; Ponec, M

    2005-01-01

    This study was undertaken to examine the role fibroblasts play in the formation of the basement membrane (BM) in human skin equivalents. For this purpose, keratinocytes were seeded on top of fibroblast-free or fibroblast-populated collagen matrix or de-epidermized dermis and cultured in the absence

  16. Shelf-life evaluation of bilayered human skin equivalent, MyDerm™.

    Science.gov (United States)

    Seet, Wan Tai; Manira, Maarof; Maarof, Manira; Khairul Anuar, Khairoji; Chua, Kien-Hui; Ahmad Irfan, Abdul Wahab; Ng, Min Hwei; Aminuddin, Bin Saim; Ruszymah, Bt Hj Idrus

    2012-01-01

    Skin plays an important role in defense against infection and other harmful biological agents. Due to its fragile structure, skin can be easily damaged by heat, chemicals, traumatic injuries and diseases. An autologous bilayered human skin equivalent, MyDerm™, was engineered to provide a living skin substitute to treat critical skin loss. However, one of the disadvantages of living skin substitute is its short shelf-life, hence limiting its distribution worldwide. The aim of this study was to evaluate the shelf-life of MyDerm™ through assessment of cell morphology, cell viability, population doubling time and functional gene expression levels before transplantation. Skin samples were digested with 0.6% Collagenase Type I followed by epithelial cells dissociation with TrypLE Select. Dermal fibroblasts and keratinocytes were culture-expanded to obtain sufficient cells for MyDerm™ construction. MyDerm™ was constructed with plasma-fibrin as temporary biomaterial and evaluated at 0, 24, 48 and 72 hours after storage at 4°C for its shelf-life determination. The morphology of skin cells derived from MyDerm™ remained unchanged across storage times. Cells harvested from MyDerm™ after storage appeared in good viability (90.5%±2.7% to 94.9%±1.6%) and had short population doubling time (58.4±8.7 to 76.9±19 hours). The modest drop in cell viability and increased in population doubling time at longer storage duration did not demonstrate a significant difference. Gene expression for CK10, CK14 and COL III were also comparable between different storage times. In conclusion, MyDerm™ can be stored in basal medium at 4°C for at least 72 hours before transplantation without compromising its functionality.

  17. Human reliability, error, and human factors in power generation

    CERN Document Server

    Dhillon, B S

    2014-01-01

    Human reliability, error, and human factors in the area of power generation have been receiving increasing attention in recent years. Each year billions of dollars are spent in the area of power generation to design, construct/manufacture, operate, and maintain various types of power systems around the globe, and such systems often fail due to human error. This book compiles various recent results and data into one volume, and eliminates the need to consult many diverse sources to obtain vital information.  It enables potential readers to delve deeper into a specific area, providing the source of most of the material presented in references at the end of each chapter. Examples along with solutions are also provided at appropriate places, and there are numerous problems for testing the reader’s comprehension.  Chapters cover a broad range of topics, including general methods for performing human reliability and error analysis in power plants, specific human reliability analysis methods for nuclear power pl...

  18. Solar Power System Evaluated for the Human Exploration of Mars

    Science.gov (United States)

    Kerslake, Thomas W.

    2000-01-01

    The electric power system is a crucial element of any mission for the human exploration of the Martian surface. The bulk of the power generated will be delivered to crew life support systems, extravehicular activity suits, robotic vehicles, and predeployed in situ resource utilization (ISRU) equipment. In one mission scenario, before the crew departs for Mars, the ISRU plant operates for 435 days producing liquefied methane and oxygen for ascent-stage propellants and water for crew life support. About 200 days after ISRU production is completed, the crew arrives for a 500-day surface stay. In this scenario, the power system must operate for a total of 1130 days (equivalent to 1100 Martian "sols"), providing 400 MW-hr of energy to the ISRU plant and up to 18 kW of daytime user power. A photovoltaic power-generation system with regenerative fuel cell (RFC) energy storage has been under study at the NASA Glenn Research Center at Lewis Field. The conceptual power system is dominated by the 4000- m2 class photovoltaic array that is deployed orthogonally as four tent structures, each approximately 5 m on a side and 100-m long. The structures are composed of composite members deployed by an articulating mast, an inflatable boom, or rover vehicles, and are subsequently anchored to the ground. Array panels consist of thin polymer membranes with thin-film solar cells. The array is divided into eight independent electrical sections with solar cell strings operating at 600 V. Energy storage is provided by regenerative fuel cells based on hydrogen-oxygen proton exchange membrane technology. Hydrogen and oxygen reactants are stored in gaseous form at 3000 psi, and the water produced is stored at 14.7 psi. The fuel cell operating temperature is maintained by a 40-m2 deployable pumped-fluid loop radiator that uses water as the working fluid. The power management and distribution (PMAD) architecture features eight independent, regulated 600-Vdc channels. Power management and

  19. Power law analysis of the human microbiome.

    Science.gov (United States)

    Ma, Zhanshan Sam

    2015-11-01

    Taylor's (1961, Nature, 189:732) power law, a power function (V = am(b) ) describing the scaling relationship between the mean and variance of population abundances of organisms, has been found to govern the population abundance distributions of single species in both space and time in macroecology. It is regarded as one of few generalities in ecology, and its parameter b has been widely applied to characterize spatial aggregation (i.e. heterogeneity) and temporal stability of single-species populations. Here, we test its applicability to bacterial populations in the human microbiome using extensive data sets generated by the US-NIH Human Microbiome Project (HMP). We further propose extending Taylor's power law from the population to the community level, and accordingly introduce four types of power-law extensions (PLEs): type I PLE for community spatial aggregation (heterogeneity), type II PLE for community temporal aggregation (stability), type III PLE for mixed-species population spatial aggregation (heterogeneity) and type IV PLE for mixed-species population temporal aggregation (stability). Our results show that fittings to the four PLEs with HMP data were statistically extremely significant and their parameters are ecologically sound, hence confirming the validity of the power law at both the population and community levels. These findings not only provide a powerful tool to characterize the aggregations of population and community in both time and space, offering important insights into community heterogeneity in space and/or stability in time, but also underscore the three general properties of power laws (scale invariance, no average and universality) and their specific manifestations in our four PLEs.

  20. Vibrational spectroscopy and microscopic imaging: novel approaches for comparing barrier physical properties in native and human skin equivalents

    Science.gov (United States)

    Yu, Guo; Zhang, Guojin; Flach, Carol R.; Mendelsohn, Richard

    2013-06-01

    Vibrational spectroscopy and imaging have been used to compare barrier properties in human skin, porcine skin, and two human skin equivalents, Epiderm 200X with an enhanced barrier and Epiderm 200 with a normal barrier. Three structural characterizations were performed. First, chain packing and conformational order were compared in isolated human stratum corneum (SC), isolated porcine SC, and in the Epiderm 200X surface layers. The infrared (IR) spectrum of isolated human SC revealed a large proportion of orthorhombically packed lipid chains at physiological temperatures along with a thermotropic phase transition to a state with hexagonally packed chains. In contrast, the lipid phase at physiological temperatures in both porcine SC and in Epiderm 200X, although dominated by conformationally ordered chains, lacked significant levels of orthorhombic subcell packing. Second, confocal Raman imaging of cholesterol bands showed extensive formation of cholesterol-enriched pockets within the human skin equivalents (HSEs). Finally, IR imaging tracked lipid barrier dimensions as well as the spatial disposition of ordered lipids in human SC and Epiderm 200X. These approaches provide a useful set of experiments for exploring structural differences between excised human skin and HSEs, which in turn may provide a rationale for the functional differences observed among these preparations.

  1. Impact of Sample Size and Variability on the Power and Type I Error Rates of Equivalence Tests: A Simulation Study

    Science.gov (United States)

    Rusticus, Shayna A.; Lovato, Chris Y.

    2014-01-01

    The question of equivalence between two or more groups is frequently of interest to many applied researchers. Equivalence testing is a statistical method designed to provide evidence that groups are comparable by demonstrating that the mean differences found between groups are small enough that they are considered practically unimportant. Few…

  2. The paradox of human equivalent dose formula: A canonical case study of abrus precatorius aqueous leaf extract in monogastric animals

    Directory of Open Access Journals (Sweden)

    Saganuwan Alhaji Saganuwan

    2016-03-01

    Full Text Available There is abundant literature on the toxicity of A. precatorius seeds. However there is a need to define the toxicity limit of the Abrus precatorius leaf in monogastric animals. Human Equivalent Dose (HED which is equal to animal dose multiplied by animal km (metabolism constant divided by human km was used to project the LD50 of fifteen monogastric animals , where human km factor is body weight (kg divided by body surface area (m2. Human Equivalent No-observable Adverse Effect Doses were determined by multiplying the animal no-observable adverse effect dose by animal weight (Wa divided by human weight (Wh. The LD50 of the aqueous leaf extract of Abrus precatorius in mice was estimated to be between 2559.5 and 3123.3 mg/kg body weight. The LD50 extrapolated from mouse to rat (1349.3-1646.6 mg/kg, hamster (1855.3-2264.1 mg/kg, guinea pig (1279.5-1561.4 mg/kg, rabbit (618.4-754.7 mg/kg, monkey (593.7-724.5 mg/kg, cat (392.7-479.2 mg/kg, dog and baboon (371.1-452.8 mg/kg, child (297-362 mg/kg and adult human (197.8-241.5 mg/kg body weight respectively could be a reality. The therapeutic safe dose range for the animals was 1-12.5 mg/kg body weight for a period of 7 days, but at a dose (≤ 200 mg/kg body weight the leaf extract showed haematinic effect. However, at a higher dose (> 200 mg/kg, the extract showed haemolytic activity in rats, whereas at a dose (≥25.0 mg/kg, the leaf extract might be organotoxic in hamster, guinea pig, rabbit, monkey, cat, dog, baboon, child and adult human if administered orally for a period of 7 days.

  3. Rho Kinase Inhibitor Y-27632 Prolongs the Life Span of Adult Human Keratinocytes, Enhances Skin Equivalent Development, and Facilitates Lentiviral Transduction

    Science.gov (United States)

    Rodijk-Olthuis, Diana; Jansen, Patrick A.M.; van Vlijmen-Willems, Ivonne M.J.J.; van Erp, Piet E.; Joosten, Irma; Zeeuwen, Patrick L.J.M.

    2012-01-01

    The use of tissue-engineered human skin equivalents (HSE) for fundamental research and industrial application requires the expansion of keratinocytes from a limited number of skin biopsies donated by adult healthy volunteers or patients. A pharmacological inhibitor of Rho-associated protein kinases, Y-27632, was recently reported to immortalize neonatal human foreskin keratinocytes. Here, we investigated the potential use of Y-27632 to expand human adult keratinocytes and evaluated its effects on HSE development and in vitro gene delivery assays. Y-27632 was found to significantly increase the life span of human adult keratinocytes (up to five to eight passages). The epidermal morphology of HSEs generated from high-passage, Y-27632-treated keratinocytes resembled the native epidermis and was improved by supplementing Y-27632 during the submerged phase of HSE development. In addition, Y-27632-treated keratinocytes responded normally to inflammatory stimuli, and could be used to generate HSEs with a psoriatic phenotype, upon stimulation with relevant cytokines. Furthermore, Y-27632 significantly enhanced both lentiviral transduction efficiency of primary adult keratinocytes and epidermal morphology of HSEs generated thereof. Our study indicates that Y-27632 is a potentially powerful tool that is used for a variety of applications of adult human keratinocytes. PMID:22519508

  4. Genotoxicity assessment of reactive and disperse textile dyes using human dermal equivalent (3D cell culture system).

    Science.gov (United States)

    Leme, Daniela Morais; Primo, Fernando Lucas; Gobo, Graciely Gomides; da Costa, Cleber Rafael Vieira; Tedesco, Antonio Claudio; de Oliveira, Danielle Palma

    2015-01-01

    Thousands of dyes are marketed daily for different purposes, including textile dyeing. However, there are several studies reporting attributing to dyes deleterious human effects such as DNA damage. Humans may be exposed to toxic dyes through either ingestion of contaminated waters or dermal contact with colored garments. With respect to dermal exposure, human skin equivalents are promising tools to assess in vitro genotoxicity of dermally applied chemicals using a three-dimensional (3D) model to mimic tissue behavior. This study investigated the sensitivity of an in-house human dermal equivalent (DE) for detecting genotoxicity of textile dyes. Two azo (reactive green 19 [RG19] and disperse red 1[DR1]) dyes and one anthraquinone (reactive blue 2 [RB2]) dye were analyzed. RG19 was genotoxic for DE in a dose-responsive manner, whereas RB2 and DR1 were nongenotoxic under the conditions tested. These findings are not in agreement with previous genotoxicological assessment of these dyes carried out using two-dimensional (2D) cell cultures, which showed that DR1 was genotoxic in human hepatoma cells (HepG2) and RG19 was nongenotoxic for normal human dermal fibroblasts (NHDF). These discrepant results probably may be due to differences between metabolic activities of each cell type (organ-specific genotoxicity, HepG2 and fibroblasts) and the test setup systems used in each study (fibroblasts cultured at 2D and three-dimensional [3D] culture systems). Genotoxicological assessment of textile dyes in context of organ-specific genotoxicity and using in vitro models that more closely resemble in vivo tissue architecture and physiology may provide more reliable estimates of genotoxic potential of these chemicals.

  5. The Equivalent Mechanical Model and Equivalent Inertia of Power Synthesis Devices%动力合成装置的等效模型及等效转动惯量

    Institute of Scientific and Technical Information of China (English)

    白钰枝; 崔亚辉

    2011-01-01

    差速行星齿轮机构用于合成运动,可以作为动力合成装置.随着石油资源的日益枯竭,混合动力汽车近年来成为汽车新宠,差速齿轮机构可以作为其中的动力合成部分.尽管动力合成装置的具体结构千差万别,但在整个传动系统中,结构参数及运动规律存在着一定的规律.用等效方法将其简化,得到动力合成装置的简化模型,并利用差动轮系的内在参数关系,推演出模型在三种工作模式下的等效转动惯量,为动力合成装置的动力学分析提供了参数基础.%Planetary gear differential which can be used for the synthesis of movement can be synthesized as a power plant. With the increasing depletion of oil resources, hybrid electric vehicles, in which differential gear mechanism can be used as part of the dynamic synthesis, become a new favorite in recent years. Although the specific structure of power synthesis devices are different, the certain laws of structural parameters and the movement are followed in the entire transmission system. Equivalent inertia under three modes is deduced by establishing equivalent mechanical model which is the basis of power matching, providing parameter base for the synthesis of the dynamics.

  6. 76 FR 787 - Notice of Availability of the Recommended Toxicity Equivalence Factors (TEFs) for Human Health...

    Science.gov (United States)

    2011-01-06

    ...-like compounds (DLCs), including polychlorinated dibenzo-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs), are structurally and toxicologically related halogenated... environment, build up in the food chain, and accumulate in the tissues of animals. Human exposures to these...

  7. Assessment of recovery from ocular irritancy using a human tissue equivalent model.

    Science.gov (United States)

    Espersen, R J; Olsen, P; Nicolaisen, G M; Jensen, B L; Rasmussen, E S

    1997-01-01

    The SKIN(2) ZK1200 tissue equivalent model has been used in an exploratory study of recovery from ocular irritation. Nine substances from the ECETOC eye irritation reference chemicals data bank were tested. The cellular viability of the tissue model was measured using the MTT assay immediately after chemical exposure and after incubation periods corresponding to observation times used in the Draize tests. The cellular viability of the tissue specimens exposed to moderate irritants, with modified maximum average score (MMAS) values between 15 and 40 (= 5), returned to control levels within 1-7 days. Tissue specimens exposed to 1 and 10% benzalkonium chloride showed significantly reduced MTT activities at day 14 and day 21. Mild ocular irritants, with MMAS values below 3 (n = 2), did not induce significant depressions of the MTT activities of the tissue specimens after 60 min exposure. A relatively good correlation (r = 0.73) was obtained between the exposure times used in vitro and Draize MMAS values. Moreover, the incubation periods needed for the exposed SKIN(2) ZK1200 to regain control MTT activities showed a good agreement (r > 0.90) with days-to-clear ocular irritancy in the Draize test.

  8. Development of a full-thickness human gingiva equivalent constructed from immortalized keratinocytes and fibroblasts

    NARCIS (Netherlands)

    J.K. Buskermolen; C.M.A. Reijnders; S.W. Spiekstra; T. Steinberg; C.J. Kleverlaan; A.J. Feilzer; A.D. Bakker; S. Gibbs

    2016-01-01

    Organotypic models make it possible to investigate the unique properties of oral mucosa in vitro. For gingiva, the use of human primary keratinocytes (KC) and fibroblasts (Fib) is limited due to the availability and size of donor biopsies. The use of physiologically relevant immortalized cell lines

  9. An Equivalent Gauge and the Equivalence Theorem

    CERN Document Server

    Wulzer, Andrea

    2014-01-01

    I describe a novel covariant formulation of massive gauge theories in which the longitudinal polarization vectors do not grow with the energy. Therefore in the present formalism, differently from the ordinary one, the energy and coupling power-counting is completely transparent at the level of individual Feynman diagrams, with obvious advantages both at the conceptual and practical level. Since power-counting is transparent, the high-energy limit of the amplitudes involving longitudinal particles is immediately taken, and the Equivalence Theorem is easily demonstrated at all orders in perturbation theory. Since the formalism makes the Equivalence Theorem self-evident, and because it is based on a suitable choice of the gauge, we can call it an "Equivalent Gauge".

  10. Responses to the Assurance game in monkeys, apes, and humans using equivalent procedures

    DEFF Research Database (Denmark)

    Brosnan, Sarah F; Parrish, Audrey; Beran, Michael J

    2011-01-01

    There is great interest in the evolution of economic behavior. In typical studies, species are asked to play one of a series of economic games, derived from game theory, and their responses are compared. The advantage of this approach is the relative level of consistency and control that emerges...... from the games themselves; however, in the typical experiment, procedures and conditions differ widely, particularly between humans and other species. Thus, in the current study, we investigated how three primate species, capuchin monkeys, chimpanzees, and humans, played the Assurance (or Stag Hunt......) game using procedures that were, to the best of our ability, the same across species, particularly with respect to training and pretesting. Our goal was to determine what, if any, differences existed in the ways in which these species made decisions in this game. We hypothesized differences along...

  11. CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents.

    Science.gov (United States)

    Ouwehand, Krista; Spiekstra, Sander W; Waaijman, Taco; Breetveld, Melanie; Scheper, Rik J; de Gruijl, Tanja D; Gibbs, Susan

    2012-10-01

    Epidermal Langerhans cells (LC) play a key role in initiation and regulation of immune responses. Whereas LC migration out of the epidermis upon environmental assault is extensively studied, the mechanisms involved in the (re)population of the epidermis with LC are poorly understood. Here, we investigated the immigration of LC derived from the human MUTZ-3 cell line (MUTZ-LC) into the epidermis of a full thickness skin equivalent, comprising a fully differentiated epidermis on a fibroblast-populated dermis. MUTZ-LC were used to determine which epidermis-derived chemokines play a role in mediating LC trans-dermal migration into the epidermis. We found evidence for a role of keratinocyte-derived CCL5 and CCL20 in the chemo-attraction of MUTZ-LC. Neutralizing antibodies against CCL5 and CCL20 blocked LC migration towards keratinocytes. Secretion of these two chemokines was associated with incorporation of MUTZ-LC into the epidermis of full thickness skin equivalents. In conclusion, our findings suggest that epidermis derived CCL5 and CCL20 are pivotal mediators in recruitment of LC into the epidermis.

  12. Ergonomic study on human-powered vehicles

    Directory of Open Access Journals (Sweden)

    Abdullah Mohd Azman

    2017-01-01

    Full Text Available In this paper, new methods for ergonomic analysis of cyclist for 4-wheel recumbent seat human-powered vehicle (HPV are performed. An ergonomic index with fundamental formulation is developed in order to determine the level of comfortness during handling of the HPV. Basic reference of sitting postures are produced from three HPVs for 20 different individuals. All the dimensions, angles and measurements are recorded. The same individuals are required to sit on the three HPV models to evaluate their comfortness and ergonomic by observing the same dimensions, angles and measurements of leg and hand postures. The data is compared with reference comfort sitting ergonomic. This study is limited to a number of individuals which are the students of a university in Malaysia with age range from 20 to 24 years old. However, the ergonomic index can be expanded for Asian people and with some improvement in the parameters, it can be used for other countries. Derivation of ergonomic index and formulation in determining the comfort level and ergonomic of HPV. Using the ergonomic index, a new improved HPV can be developed. The index is also applicable with modification on several parameters in the formulation for other countries.

  13. Composition Modeling and Equivalence of an Integrated Power Generation System of Wind, Photovoltaic and Energy Storage Unit

    Institute of Scientific and Technical Information of China (English)

    WANG Haohuai; TANG Yong; HOU Junxian; ZOU Jiangfeng; LIANGShuang; SU Feng

    2011-01-01

    The characteristic of wind and solar generation is random and fluctuant. In order to improve their generation performance, the integrated power generation of wind, photovoltaic (PV) and energy storage is a focus in the study. In this paper,

  14. Comparison of different detector performance for the assessment of neutron personal equivalent dose in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Ginjaume, M.; Ortega, X.; Duch, M.A.; Tares, M. [Catalunya Univ. Politecnica, Instituto de Tecnicas Energeticas (Spain); Fernandez, F. [Barcelona Univ. Autonoma, Grupo de Fisica de las Radiaciones (Spain)

    2006-07-01

    The aim of the study was to investigate and to compare the performance of the most widely used neutron survey instruments in Spain with two available TLD systems and some of the new electronic neutron personal dosemeters at some selected sites of three nuclear power plants. In this paper preliminary main results of the first two measuring surveys, in the Asco 1 and Asco 2 power plants, are presented. (N.C.)

  15. Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Sang Hoon; Kim, Jae Hwan; Yi, Sang Min [Laboratory of Cell Signaling and Nanomedicine, Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science, Korea University College of Medicine, Seoul (Korea, Republic of); Lee, Jung Pyo; Kim, Jin Ho; Sohn, Kyung Hee; Park, Kui Lea [National Institute of Toxicological Research, Seoul (Korea, Republic of); Kim, Meyoung-Kon [Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul (Korea, Republic of); Son, Sang Wook, E-mail: skin4u@korea.ac.kr [Laboratory of Cell Signaling and Nanomedicine, Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science, Korea University College of Medicine, Seoul (Korea, Republic of)

    2010-04-09

    Quantum dots (QDs) are rapidly emerging as an important class of nanoparticles (NPs) with potential applications in medicine. However, little is known about penetration of QDs through human skin. This study investigated skin penetration of QDs in both in vivo and in vitro human skin. Using the tape stripping method, this study demonstrates for the first time that QDs can actually penetrate through the stratum corneum (SC) of human skin. Transmission electron microscope (TEM) and energy diverse X-ray (EDX) analysis showed accumulation of QDs in the SC of a human skin equivalent model (HSEM) after dermal exposure to QDs. These findings suggest possible transdermal absorption of QDs after dermal exposure over a relatively long period of time.

  16. Equivalent dynamical complexity in a many-body quantum and collective human system

    CERN Document Server

    Johnson, Neil F; Zhao, Zhenyuan; Quiroga, Luis

    2010-01-01

    Proponents of Complexity Science believe that the huge variety of emergent phenomena observed throughout nature, are generated by relatively few microscopic mechanisms [1-7]. Skeptics however point to the lack of concrete examples in which a single mechanistic model manages to capture relevant macroscopic and microscopic properties for two or more distinct systems operating across radically different length and time scales. Here we show how a single complexity model built around cluster coalescence and fragmentation, can cross the fundamental divide between many-body quantum physics and social science. It simultaneously (i) explains a mysterious recent finding concerning quantum many-body effects in cuprate superconductors [8,9] (i.e. scale of 10^{-9}-10^{-4} meters and 10^{-12}-10^{-6} seconds), (ii) explains the apparent universality of the casualty distributions in distinct human insurgencies and terrorism [10] (i.e. scale of 10^{3}-10^{6} meters and 10^{4}-10^{8} seconds), (iii) shows consistency with var...

  17. Mitochondrial compromise in 3-year old patas monkeys exposed in utero to human-equivalent antiretroviral therapies.

    Science.gov (United States)

    Liu, Yongmin; Shim Park, Eunwoo; Gibbons, Alexander T; Shide, Eric D; Divi, Rao L; Woodward, Ruth A; Poirier, Miriam C

    2016-08-01

    Antiretroviral (ARV) drug therapy, given during pregnancy for prevention of mother-to-child transmission of human immunodeficiency virus 1 (HIV-1), induces fetal mitochondrial dysfunction in some children. However, the persistence/reversibility of that dysfunction is unclear. Here we have followed Erythrocebus patas (patas) monkey offspring for up to 3 years of age (similar in development to a 15-year old human) after exposure of the dams to human-equivalent in utero ARV exposure protocols. Pregnant patas dams (3-5/exposure group) were given ARV drug combinations that included zidovudine (AZT)/lamivudine (3TC)/abacavir (ABC), or AZT/3TC/nevirapine (NVP), for the last 10 weeks (50%) of gestation. Infants kept for 1 and 3 years also received drug for the first 6 weeks of life. In offpsring at birth, 1 and 3 years of age mitochondrial morphology, examined by electron microscopy (EM), was compromised compared to the unexposed controls. Mitochondrial DNA (mtDNA), measured by hybrid capture chemiluminescence assay (HCCA) was depleted in hearts of patas exposed to AZT/3TC/NVP at all ages (P year-old patas offspring was ∼50% reduced in AZT/3TC/ABC-exposed patas (P year-old patas sustain persistent mitochondrial dysfunction as a result of perinatal ARV drug exposure. Environ. Mol. Mutagen. 57:526-534, 2016. © 2016 Wiley Periodicals, Inc.

  18. High-fructose corn syrup and sucrose have equivalent effects on energy-regulating hormones at normal human consumption levels.

    Science.gov (United States)

    Yu, Zhiping; Lowndes, Joshua; Rippe, James

    2013-12-01

    Intake of high-fructose corn syrup (HFCS) has been suggested to contribute to the increased prevalence of obesity, whereas a number of studies and organizations have reported metabolic equivalence between HFCS and sucrose. We hypothesized that HFCS and sucrose would have similar effects on energy-regulating hormones and metabolic substrates at normal levels of human consumption and that these values would not change over a 10-week, free-living period at these consumption levels. This was a randomized, prospective, double-blind, parallel group study in which 138 adult men and women consumed 10 weeks of low-fat milk sweetened with either HFCS or sucrose at levels of the 25th, 50th, and 90th percentile population consumption of fructose (the equivalent of 40, 90, or 150 g of sugar per day in a 2000-kcal diet). Before and after the 10-week intervention, 24-hour blood samples were collected. The area under the curve (AUC) for glucose, insulin, leptin, active ghrelin, triglyceride, and uric acid was measured. There were no group differences at baseline or posttesting for all outcomes (interaction, P > .05). The AUC response of glucose, active ghrelin, and uric acid did not change between baseline and posttesting (P > .05), whereas the AUC response of insulin (P < .05), leptin (P < .001), and triglyceride (P < .01) increased over the course of the intervention when the 6 groups were averaged. We conclude that there are no differences in the metabolic effects of HFCS and sucrose when compared at low, medium, and high levels of consumption.

  19. Evaluation of tissue-equivalent materials to be used as human brain tissue substitute in dosimetry for diagnostic radiology

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, C.C., E-mail: cassio.c.ferreira@gmail.co [Departamento de Fisica, Universidade Federal de Sergipe, Postal Code 353, Sergipe-SE 49100-000 (Brazil); Ximenes Filho, R.E.M., E-mail: raimundoximenes@hotmail.co [Departamento de Fisica, Universidade Federal de Sergipe, Postal Code 353, Sergipe-SE 49100-000 (Brazil); Vieira, J.W., E-mail: jwvieira@br.inter.ne [Centro Federal de Educacao Tecnologica de Pernambuco (CEFET-PE), Av. Professor Luiz Freire, 500 Curado, CEP 50740-540, Recife (Brazil); Escola Politecnica de Pernambuco, Universidade de Pernambuco (EPP/UPE), Rua Benfica, 455, Madalena, CEP 50720-001, Recife (Brazil); Tomal, A., E-mail: alessandratomal@pg.ffclrp.usp.b [Departamento de Fisica e Matematica, FFCLRP, Universidade de Sao Paulo, Ribeirao Preto-SP 14040-90 (Brazil); Poletti, M.E., E-mail: poletti@ffclrp.usp.b [Departamento de Fisica e Matematica, FFCLRP, Universidade de Sao Paulo, Ribeirao Preto-SP 14040-90 (Brazil); Garcia, C.A.B., E-mail: cgarcia@ufs.b [Departamento de Quimica, Universidade Federal de Sergipe, Postal Code 353, Sergipe-SE 49100-000 (Brazil); Maia, A.F., E-mail: afmaia@ufs.b [Departamento de Fisica, Universidade Federal de Sergipe, Postal Code 353, Sergipe-SE 49100-000 (Brazil)

    2010-08-15

    Tissue-equivalent materials to be used as substitutes for human brain tissue in dosimetry for diagnostic radiology have been investigated in terms of calculated total mass attenuation coefficient ({mu}/{rho}), calculated mass energy-absorption coefficient ({mu}{sub en}/{rho}) and absorbed dose. Measured linear attenuation coefficients ({mu}) have been used for benchmarking the calculated total mass attenuation coefficient ({mu}/{rho}). The materials examined were bolus, nylon (registered) , orange articulation wax, red articulation wax, PMMA (polymethylmethacrylate), bees wax, paraffin I, paraffin II, pitch and water. The results show that water is the best substitute for brain among the materials investigated. The average percentage differences between the calculated {mu}/{rho} and {mu}{sub en}/{rho} coefficients for water and those for brain were 1.0% and 2.5%, respectively. Absorbed doses determined by Monte Carlo methods confirm water as being the best brain substitute to be used in dosimetry for diagnostic radiology, showing maximum difference of 0.01%. Additionally this study showed that PMMA, a material often used for the manufacturing of head phantoms for computed tomography, cannot be considered to be a suitable substitute for human brain tissue in dosimetry.

  20. Measuring and Calculation on Wind Power Value Based on Strain Equivalent Electricity Quantity Frequency Method%基于应变型等效电量频率法的风电价值测算

    Institute of Scientific and Technical Information of China (English)

    吴拥勋; 江岳文; 温步瀛

    2014-01-01

    This paper introduces measuring and calculation on each part value caused after grid connected with wind power. Wind power value was divided into positive value which included environmental value and social value and negative value which included changes of load adjustment cost,frequency adjustment cost and spinning reserve cost caused by uncertainty and peak shaving characteristic of wind power.Thereinto,the environmental value included emission benefit,water saving benefit and resource benefit while the social value indicated active impact on human health by environmental value of wind power.At last,by using improved equivalent electricity quantity frequency method (be called for short as strain equivalent electricity quantity frequency method),random production simulation was conducted for the example and each part value was analyzed according to simulation results.%测算了风电并网后引起的各部分价值,将风电的价值分为正面价值和负面价值,正面价值包括环境价值、社会价值,其中环境效益包括减排效益、节水效益、资源效益,社会价值指的是风电的环境效益对人类健康带来的积极影响;负面价值包括因风电的不确定性、反调峰特性而造成调峰成本、调频成本和旋转备用成本变化。最后利用改进后的等效电量频率法(简称应变型等效电量频率法)对算例进行随机生产模拟,根据模拟结果对各部分价值进行分析。

  1. Dream of future on human-machine cooperative system; Ningen robot system ni okeru fluid power gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Y. [Hosei University, Tokyo (Japan). Faculty of Engineering

    2000-01-15

    This paper describes the human-machine cooperative system and fluid power technology. Most of Japanese robot R and D activities shifted from early R and D on hydraulic or pneumatic driving to that on simple electric driving, and development of fluid power technology as actuator and control technology is retarded. For creating an artificial work environment with a presence by virtual reality formation technology, an equipment (actuator) directly acting such five senses (sensor) of operators as visual, auditory, pressure and contact senses is essential. Pneumatic actuator is extremely suitable for such one because of its small size, light weight, safety and high power density. Robocup has been held as the soccer game of many autonomous robots. For the soccer game of human beings and robots, development of such technologies for advanced autonomous robots is necessary as realtime processing, advanced intelligence, human friendliness, safety, high-efficiency high-power actuator equivalent to human muscle, and energy source. (NEDO)

  2. Self-Powered Human-Interactive Transparent Nanopaper Systems.

    Science.gov (United States)

    Zhong, Junwen; Zhu, Hongli; Zhong, Qize; Dai, Jiaqi; Li, Wenbo; Jang, Soo-Hwan; Yao, Yonggang; Henderson, Doug; Hu, Qiyi; Hu, Liangbing; Zhou, Jun

    2015-07-28

    Self-powered human-interactive but invisible electronics have many applications in anti-theft and anti-fake systems for human society. In this work, for the first time, we demonstrate a transparent paper-based, self-powered, and human-interactive flexible system. The system is based on an electrostatic induction mechanism with no extra power system appended. The self-powered, transparent paper device can be used for a transparent paper-based art anti-theft system in museums or for a smart mapping anti-fake system in precious packaging and documents, by virtue of the advantages of adding/removing freely, having no impairment on the appearance of the protected objects, and being easily mass manufactured. This initial study bridges the transparent nanopaper with a self-powered and human-interactive electronic system, paving the way for the development of smart transparent paper electronics.

  3. Study of dose distribution in a human body in international space station compartments with the tissue-equivalent spherical phantom

    Science.gov (United States)

    Shurshakov, Vyacheslav A.; Tolochek, Raisa V.; Kartsev, Ivan S.; Petrov, Vladislav M.; Nikolaev, Igor V.; Moskalyova, Svetlana I.; Lyagushin, Vladimir I.

    2014-01-01

    Space radiation is known to be key hazard of manned space mission. To estimate accurately radiation health risk detailed study of dose distribution inside human body by means of human phantom is conducted. In the space experiment MATROSHKA-R, the tissue-equivalent spherical phantom (32 kg mass, 35 cm diameter and 10 cm central spherical cave) made in Russia has been used on board the ISS for more than 8 years. Owing to the specially chosen phantom shape and size, the chord length distributions of the detector locations are attributed to self-shielding properties of the critical organs in a real human body. If compared with the anthropomorphic phantom Rando used inside and outside the ISS, the spherical phantom has lower mass, smaller size and requires less crew time for the detector installation/retrieval; its tissue-equivalent properties are closer to the standard human body tissue than the Rando-phantom material. Originally the spherical phantom was installed in the star board crew cabin of the ISS Service Module, then in the Piers-1, MIM-2 and MIM-1 modules of the ISS Russian segment, and finally in JAXA Kibo module. Total duration of the detector exposure is more than 1700 days in 8 sessions. In the first phase of the experiment with the spherical phantom, the dose measurements were realized with only passive detectors (thermoluminescent and solid-state track detectors). The detectors are placed inside the phantom along the axes of 20 containers and on the phantom outer surface in 32 pockets of the phantom jacket. After each session the passive detectors are returned to the ground. The results obtained show the dose difference on the phantom surface as much as a factor of 2, the highest dose being observed close to the outer wall of the compartment, and the lowest dose being in the opposite location along the phantom diameter. Maximum dose rate measured in the phantom is obviously due to the galactic cosmic ray (GCR) and Earth' radiation belt contribution on

  4. Human Factors in Nuclear Power Engineering in Polish Conditions

    Directory of Open Access Journals (Sweden)

    Agnieszka Kaczmarek-Kacprzak

    2014-09-01

    Full Text Available The paper “Human factors in nuclear power engineering in Polish conditions” focuses on analysis of dynamics of preparing Polish society to build fi rst nuclear power plant in XXI century in Poland. Authors compare experience from constructing nuclear power plant Sizewell B (Great Britain and Sizewell C, which is in preparation phase with polish nuclear power program. Paper includes aspects e.g. of creating nuclear safety culture and social opinion about investment. Human factors in nuclear power engineering are as well important as relevant economical and technical factors, but very often negligible. In Poland where history about Czarnobyl is still alive, and social opinion is created on emotions after accident in Fukushima, human factors are crucial and should be under comprehensive consideration.

  5. Virial Coefficients from Unified Statistical Thermodynamics of Quantum Gases Trapped under Generic Power Law Potential in d Dimension and Equivalence of Quantum Gases

    Science.gov (United States)

    Bahauddin, Shah Mohammad; Mehedi Faruk, Mir

    2016-09-01

    From the unified statistical thermodynamics of quantum gases, the virial coefficients of ideal Bose and Fermi gases, trapped under generic power law potential are derived systematically. From the general result of virial coefficients, one can produce the known results in d = 3 and d = 2. But more importantly we found that, the virial coefficients of Bose and Fermi gases become identical (except the second virial coefficient, where the sign is different) when the gases are trapped under harmonic potential in d = 1. This result suggests the equivalence between Bose and Fermi gases established in d = 1 (J. Stat. Phys. DOI 10.1007/s10955-015-1344-4). Also, it is found that the virial coefficients of two-dimensional free Bose (Fermi) gas are equal to the virial coefficients of one-dimensional harmonically trapped Bose (Fermi) gas.

  6. Gyrokinetic equivalence

    Energy Technology Data Exchange (ETDEWEB)

    Parra, Felix I; Catto, Peter J [Plasma Science and Fusion Center, MIT, Cambridge, MA 02139 (United States)], E-mail: fparra@mit.edu, E-mail: catto@psfc.mit.edu

    2009-06-15

    We compare two different derivations of the gyrokinetic equation: the Hamiltonian approach in Dubin D H E et al (1983 Phys. Fluids 26 3524) and the recursive methodology in Parra F I and Catto P J (2008 Plasma Phys. Control. Fusion 50 065014). We prove that both approaches yield the same result at least to second order in a Larmor radius over macroscopic length expansion. There are subtle differences in the definitions of some of the functions that need to be taken into account to prove the equivalence.

  7. Gyrokinetic equivalence

    Science.gov (United States)

    Parra, Felix I.; Catto, Peter J.

    2009-06-01

    We compare two different derivations of the gyrokinetic equation: the Hamiltonian approach in Dubin D H E et al (1983 Phys. Fluids 26 3524) and the recursive methodology in Parra F I and Catto P J (2008 Plasma Phys. Control. Fusion 50 065014). We prove that both approaches yield the same result at least to second order in a Larmor radius over macroscopic length expansion. There are subtle differences in the definitions of some of the functions that need to be taken into account to prove the equivalence.

  8. A Self-Powered Insole for Human Motion Recognition

    Science.gov (United States)

    Han, Yingzhou; Cao, Yalu; Zhao, Jingjing; Yin, Yajiang; Ye, Liangchen; Wang, Xiaofeng; You, Zheng

    2016-01-01

    Biomechanical energy harvesting is a feasible solution for powering wearable sensors by directly driving electronics or acting as wearable self-powered sensors. A wearable insole that not only can harvest energy from foot pressure during walking but also can serve as a self-powered human motion recognition sensor is reported. The insole is designed as a sandwich structure consisting of two wavy silica gel film separated by a flexible piezoelectric foil stave, which has higher performance compared with conventional piezoelectric harvesters with cantilever structure. The energy harvesting insole is capable of driving some common electronics by scavenging energy from human walking. Moreover, it can be used to recognize human motion as the waveforms it generates change when people are in different locomotion modes. It is demonstrated that different types of human motion such as walking and running are clearly classified by the insole without any external power source. This work not only expands the applications of piezoelectric energy harvesters for wearable power supplies and self-powered sensors, but also provides possible approaches for wearable self-powered human motion monitoring that is of great importance in many fields such as rehabilitation and sports science. PMID:27649188

  9. Board power and organizational effectiveness among human service agencies.

    Science.gov (United States)

    Provan, K G

    1980-06-01

    This study examines the importance of an externally powerful board of directors to the effectiveness (ability to attract scarce resources) of 46 human service agencies operating within the same community. Traditional assumptions regarding the importance of a powerful board were supported when effectiveness was operationalized using static measures of funding but were not supported when dynamic measures were used.

  10. Human exploration of space and power development

    Science.gov (United States)

    Cohen, Aaron

    The possible role of Solar Power Satellites (SPS) in advancing the goals of the Space Exploration Initiative is considered. Three approaches are examined: (1) the use of lunar raw materials to construct a large SPS in GEO, (2) the construction of a similar system on the lunar surface, and (3) a combination of (1) and (2). Emphasis is given to the mining of He-3 from the moon and its use by the SPS.

  11. Rho kinase inhibitor y-27632 prolongs the life span of adult human keratinocytes, enhances skin equivalent development, and facilitates lentiviral transduction.

    NARCIS (Netherlands)

    Bogaard, E.H.J. van den; Rodijk-Olthuis, D.; Jansen, P.A.M.; Vlijmen-Willems, I.M.J.J. van; Erp, P.E.J. van; Joosten, I.; Zeeuwen, P.L.J.M.; Schalkwijk, J.

    2012-01-01

    The use of tissue-engineered human skin equivalents (HSE) for fundamental research and industrial application requires the expansion of keratinocytes from a limited number of skin biopsies donated by adult healthy volunteers or patients. A pharmacological inhibitor of Rho-associated protein kinases,

  12. Selection of the most appropriate two-dosemeter algorithm for estimating effective dose equivalent during maintenance periods in Korean nuclear power plants.

    Science.gov (United States)

    Kim, Hee Geun; Kong, Tae Young

    2010-07-01

    The application of a two-dosemeter system with its algorithm, as well as a test of its use in an inhomogeneous high-radiation field, is described in this study. The goal was to improve the method for estimating the effective dose equivalent during maintenance periods at Korean Nuclear Power Plants (NPPs). The use of this method in Korean and international NPPs, including those NPPs in the USA and Canada, was also investigated. The algorithms used by the the American National Standards Institute, Lakshmanan, the National Council on Radiation Protection and Measurements (NCRP), the Electric Power Research Institute and Kim were extensively analysed as two-dosemeter algorithms. Their possible application to NPPs was evaluated using data for each algorithm from two-dosemeter results that were obtained from an inhomogeneous high-radiation field during maintenance periods at Korean NPPs. The NCRP algorithm (55:50) was selected as an optimal two-dosemeter algorithm for Korean NPPs by taking into account the field test results and the convenience of wearing two dosemeters.

  13. Influence of temperature and fat content on ideal sucrose concentration, sweetening power, and sweetness equivalence of different sweeteners in chocolate milk beverage.

    Science.gov (United States)

    Paixão, J A; Rodrigues, J B; Esmerino, E A; Cruz, A G; Bolini, H M A

    2014-12-01

    The introduction of new products catering to specific dietary needs and the corresponding changes in the consumer profile reflect a growing demand for diet and “light” products. However, little information is available regarding the sensory effects of different sweeteners in products consumed at different temperatures and with varying fat contents. In this regard, this study aimed to determine the influence of temperature and fat content on the ideal sucrose concentration and the sweetness equivalence and sweetening power of different sweeteners: Neotame (NutraSweet Corp., Chicago, IL), aspartame, neosucralose, sucralose, and stevia (95% rebaudioside A), with sucrose as reference, in a chocolate milk beverage using a just-about-right (JAR) scale and magnitude estimation. Increasing temperature of consumption had an inverse effect on the ideal sucrose concentration in whole milk beverages, whereas no difference was noted in beverages made skim milk. In addition, a decrease in sweetening power was observed for all of the sweeteners analyzed considering the same conditions. The findings suggest that different optimal conditions exist for consumption of chocolate milk beverage related to sweetness perception, which depends on the fat level of milk used in the formulation. This information can be used by researchers and dairy processors when developing chocolate milk beverage formulations.

  14. Human-powered Sorts and Joins

    CERN Document Server

    Marcus, Adam; Karger, David; Madden, Samuel; Miller, Robert

    2011-01-01

    Crowdsourcing markets like Amazon's Mechanical Turk (MTurk) make it possible to task people with small jobs, such as labeling images or looking up phone numbers, via a programmatic interface. MTurk tasks for processing datasets with humans are currently designed with significant reimplementation of common workflows and ad-hoc selection of parameters such as price to pay per task. We describe how we have integrated crowds into a declarative workflow engine called Qurk to reduce the burden on workflow designers. In this paper, we focus on how to use humans to compare items for sorting and joining data, two of the most common operations in DBMSs. We describe our basic query interface and the user interface of the tasks we post to MTurk. We also propose a number of optimizations, including task batching, replacing pairwise comparisons with numerical ratings, and pre-filtering tables before joining them, which dramatically reduce the overall cost of running sorts and joins on the crowd. In an experiment joining tw...

  15. NUNDO: a numerical model of a human torso phantom and its application to effective dose equivalent calculations for astronauts at the ISS.

    Science.gov (United States)

    Puchalska, Monika; Bilski, Pawel; Berger, Thomas; Hajek, Michael; Horwacik, Tomasz; Körner, Christine; Olko, Pawel; Shurshakov, Vyacheslav; Reitz, Günther

    2014-11-01

    The health effects of cosmic radiation on astronauts need to be precisely quantified and controlled. This task is important not only in perspective of the increasing human presence at the International Space Station (ISS), but also for the preparation of safe human missions beyond low earth orbit. From a radiation protection point of view, the baseline quantity for radiation risk assessment in space is the effective dose equivalent. The present work reports the first successful attempt of the experimental determination of the effective dose equivalent in space, both for extra-vehicular activity (EVA) and intra-vehicular activity (IVA). This was achieved using the anthropomorphic torso phantom RANDO(®) equipped with more than 6,000 passive thermoluminescent detectors and plastic nuclear track detectors, which have been exposed to cosmic radiation inside the European Space Agency MATROSHKA facility both outside and inside the ISS. In order to calculate the effective dose equivalent, a numerical model of the RANDO(®) phantom, based on computer tomography scans of the actual phantom, was developed. It was found that the effective dose equivalent rate during an EVA approaches 700 μSv/d, while during an IVA about 20 % lower values were observed. It is shown that the individual dose based on a personal dosimeter reading for an astronaut during IVA results in an overestimate of the effective dose equivalent of about 15 %, whereas under an EVA conditions the overestimate is more than 200 %. A personal dosemeter can therefore deliver quite good exposure records during IVA, but may overestimate the effective dose equivalent received during an EVA considerably.

  16. Intelligent (Autonomous) Power Controller Development for Human Deep Space Exploration

    Science.gov (United States)

    Soeder, James; Raitano, Paul; McNelis, Anne

    2016-01-01

    As NASAs Evolvable Mars Campaign and other exploration initiatives continue to mature they have identified the need for more autonomous operations of the power system. For current human space operations such as the International Space Station, the paradigm is to perform the planning, operation and fault diagnosis from the ground. However, the dual problems of communication lag as well as limited communication bandwidth beyond GEO synchronous orbit, underscore the need to change the operation methodology for human operation in deep space. To address this need, for the past several years the Glenn Research Center has had an effort to develop an autonomous power controller for human deep space vehicles. This presentation discusses the present roadmap for deep space exploration along with a description of conceptual power system architecture for exploration modules. It then contrasts the present ground centric control and management architecture with limited autonomy on-board the spacecraft with an advanced autonomous power control system that features ground based monitoring with a spacecraft mission manager with autonomous control of all core systems, including power. It then presents a functional breakdown of the autonomous power control system and examines its operation in both normal and fault modes. Finally, it discusses progress made in the development of a real-time power system model and how it is being used to evaluate the performance of the controller and well as using it for verification of the overall operation.

  17. POWER AND HUMAN'S FREEDOM INTERACTION IN CONTEMPORARY WORLD

    Directory of Open Access Journals (Sweden)

    Khatsenko A. N.

    2015-09-01

    Full Text Available Hereby we substantiate the necessity of social philosophical analysis of power phenomena as due to power relations' change a human being and his values also transform. A knowledge convertation into power recourse has become a reason for authority humanization and democracy thus leading to total humans enslavement. People's intentions in aims achievement, their effectiveness and high level of organization let the authority not only manage them but also produce «obedient bodies». The authority area or in other words «focused» territory, or already experienced human activities and existing terms grow and widens. New social benefits and mobile shapes disconnected with «place» and territory appear. Thus, the «authority deterritorization» leads to the responsibility refusal for any actions and effective management consequences. New authority shapes start being exhibited as total control abolishment, where a person gains absolute choice of freedom solving his vital problems but without being supplied with choice bases. In today's world an authority, whose mission is to protect humans from anarchy, chooses risk as a new management paradigm. The mentioned reasons' entity depersonalizes the power relations where not only subordinates but also authorities become impersonal, where «authority subjects disappear». The contemporary authority research works by Alvin Toffler, Michel Foucault, Sigmund Bauman, focusing at power relations, determine the authority nature as an indefinite, newly shape taking and remoted from its final research definition

  18. Interactive short-term effects of equivalent temperature and air pollution on human mortality in Berlin and Lisbon.

    Science.gov (United States)

    Burkart, Katrin; Canário, Paulo; Breitner, Susanne; Schneider, Alexandra; Scherber, Katharina; Andrade, Henrique; Alcoforado, Maria João; Endlicher, Wilfried

    2013-12-01

    There is substantial evidence that both temperature and air pollution are predictors of mortality. Thus far, few studies have focused on the potential interactive effects between the thermal environment and different measures of air pollution. Such interactions, however, are biologically plausible, as (extreme) temperature or increased air pollution might make individuals more susceptible to the effects of each respective predictor. This study investigated the interactive effects between equivalent temperature and air pollution (ozone and particulate matter) in Berlin (Germany) and Lisbon (Portugal) using different types of Poisson regression models. The findings suggest that interactive effects exist between air pollutants and equivalent temperature. Bivariate response surface models and generalised additive models (GAMs) including interaction terms showed an increased risk of mortality during periods of elevated equivalent temperatures and air pollution. Cold effects were mostly unaffected by air pollution. The study underscores the importance of air pollution control in mitigating heat effects.

  19. The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human

    Directory of Open Access Journals (Sweden)

    Yuan Qiaoping

    2012-06-01

    Full Text Available Abstract Background As a model organism in biomedicine, the rhesus macaque (Macaca mulatta is the most widely used nonhuman primate. Although a draft genome sequence was completed in 2007, there has been no systematic genome-wide comparison of genetic variation of this species to humans. Comparative analysis of functional and nonfunctional diversity in this highly abundant and adaptable non-human primate could inform its use as a model for human biology, and could reveal how variation in population history and size alters patterns and levels of sequence variation in primates. Results We sequenced the mRNA transcriptome and H3K4me3-marked DNA regions in hippocampus from 14 humans and 14 rhesus macaques. Using equivalent methodology and sampling spaces, we identified 462,802 macaque SNPs, most of which were novel and disproportionately located in the functionally important genomic regions we had targeted in the sequencing. At least one SNP was identified in each of 16,797 annotated macaque genes. Accuracy of macaque SNP identification was conservatively estimated to be >90%. Comparative analyses using SNPs equivalently identified in the two species revealed that rhesus macaque has approximately three times higher SNP density and average nucleotide diversity as compared to the human. Based on this level of diversity, the effective population size of the rhesus macaque is approximately 80,000 which contrasts with an effective population size of less than 10,000 for humans. Across five categories of genomic regions, intergenic regions had the highest SNP density and average nucleotide diversity and CDS (coding sequences the lowest, in both humans and macaques. Although there are more coding SNPs (cSNPs per individual in macaques than in humans, the ratio of dN/dS is significantly lower in the macaque. Furthermore, the number of damaging nonsynonymous cSNPs (have damaging effects on protein functions from PolyPhen-2 prediction in the macaque is more

  20. Application of Extension Sliding Mode Strategy to Maximum Power Point Tracking in Human Power Generation Systems

    Directory of Open Access Journals (Sweden)

    Meng-Hui Wang

    2015-08-01

    Full Text Available Sliding mode strategy (SMS for maximum power point tracking (MPPT is used in this study of a human power generation system. This approach ensures maximum power at different rotation speeds to increase efficiency and corrects for the lack of robustness in traditional methods. The intelligent extension theory is used to reduce input saturation and high frequency switching in sliding mode strategy, as well as to increase the efficiency and response speed. The experimental results show that the efficiency of the extension SMS (ESMS is 5% higher than in traditional SMS, and the response is 0.5 s faster.

  1. Lysyl oxidase-like and lysyl oxidase are present in the dermis and epidermis of a skin equivalent and in human skin and are associated to elastic fibers.

    Science.gov (United States)

    Noblesse, Emmanuelle; Cenizo, Valérie; Bouez, Charbel; Borel, Agnès; Gleyzal, Claudine; Peyrol, Simone; Jacob, Marie-Paule; Sommer, Pascal; Damour, Odile

    2004-03-01

    Elastic fiber formation involves the secretion of tropoelastin which is converted to insoluble elastin by cross-linking, initiated by the oxidative deamination of lysine residues by lysyl oxidase. Five lysyl oxidase genes have been discovered. This study deals with the expression of two isoforms, LOX and LOX-like (LOXL), in human foreskin and in a human skin-equivalent (SE) model that allows the formation of elastic fibers. In this model, keratinocytes are added to a dermal equivalent made of fibroblasts grown on a chitosan-cross-linked collagen-GAG matrix. LOX and LOXL were detected by immunohistochemistry in the dermis and the epidermis of both normal skin and in a SE. This expression was confirmed by in situ hybridization on the SE. LOX and LOXL expression patterns were confirmed in human skin. The ultrastructural localization of LOXL was indicative of its association with elastin-positive materials within the SE and human skin, though interaction with collagen could not be discarded. LOX was found on collagen fibers and could be associated with elastin-positive materials in the SE and human skin. LOXL and LOX were detected in keratinocytes where LOX was mainly expressed by differentiating keratinocytes, in contrast to LOXL that can be found in both proliferating and differentiating fibroblasts. These data favor a role for LOXL in elastic fiber formation, together with LOX, and within the epidermis where both enzymes should play a role in post-translational modification of yet unknown substrates.

  2. Human factor engineering applied to nuclear power plant design

    Energy Technology Data Exchange (ETDEWEB)

    Manrique, A. [TECNATOM SA, BWR General Electric Business Manager, Madrid (Spain); Valdivia, J.C. [TECNATOM SA, Operation Engineering Project Manager, Madrid (Spain); Jimenez, A. [TECNATOM SA, Operation Engineering Div. Manager, Madrid (Spain)

    2001-07-01

    For the design and construction of new nuclear power plants as well as for maintenance and operation of the existing ones new man-machine interface designs and modifications are been produced. For these new designs Human Factor Engineering must be applied the same as for any other traditional engineering discipline. Advantages of implementing adequate Human Factor Engineering techniques in the design of nuclear reactors have become not only a fact recognized by the majority of engineers and operators but also an explicit requirement regulated and mandatory for the new designs of the so called advanced reactors. Additionally, the big saving achieved by a nuclear power plant having an operating methodology which significantly decreases the risk of operating errors makes it necessary and almost vital its implementation. The first step for this is preparing a plan to incorporate all the Human Factor Engineering principles and developing an integral design of the Instrumentation and Control and Man-machine interface systems. (author)

  3. A synergetic use of hydrogen and fuel cells in human spaceflight power systems

    Science.gov (United States)

    Belz, S.

    2016-04-01

    Hydrogen is very flexible in different fields of application of energy conversion. It can be generated by water electrolysis. Stored in tanks it is available for re-electrification by fuel cells. But it is not only the power system, which benefits from use of hydrogen, but also the life support system, which can contain hydrogen consuming technologies for recycling management (e.g. carbon dioxide removal and waste combustion processes). This paper points out various fields of hydrogen use in a human spaceflight system. Depending on mission scenarios, shadow phases, and the need of energy storage, regenerative fuel cell systems can be more efficient than secondary batteries. Here, different power storage concepts are compared by equivalent system mass calculation, thus including impact in the peripheral structure (volume, thermal management, etc.) on the space system. It is also focused on the technical integration aspect, e.g. which peripheral components have to be adapted when hydrogen is also used for life support technologies and what system mass benefit can be expected. Finally, a recommendation is given for the following development steps for a synergetic use of hydrogen and fuel cells in human spaceflight power systems.

  4. Response of human limbal epithelial cells to wounding on 3D RAFT tissue equivalents: effect of airlifting and human limbal fibroblasts.

    Science.gov (United States)

    Massie, Isobel; Levis, Hannah J; Daniels, Julie T

    2014-10-01

    Limbal epithelial stem cell deficiency can cause blindness but may be treated by human limbal epithelial cell (hLE) transplantation, normally on human amniotic membrane. Clinical outcomes using amnion can be unreliable and so we have developed an alternative tissue equivalent (TE), RAFT (Real Architecture for 3D Tissue), which supports hLE expansion, and stratification when airlifted. Human limbal fibroblasts (hLF) may be incorporated into RAFT TEs, where they support overlying hLE and improve phenotype. However, the impact of neither airlifting nor hLF on hLE function has been investigated. hLE on RAFT TEs (±hLF and airlifting) were wounded using heptanol and re-epithelialisation (fluorescein diacetate staining), and percentage putative stem cell marker p63α and proliferative marker Ki67 expression (wholemount immunohistochemistry), measured. Airlifted, hLF- RAFT TEs were unable to close the wound and p63α expression was 7 ± 0.2% after wounding. Conversely, non-airlifted, hLF- RAFT TEs closed the wound within 9 days and p63α expression was higher at 22 ± 5% (p < 0.01). hLE on both hLF- and hLF+ RAFT TEs (non-airlifted) closed the wound and p63α expression was 26 ± 8% and 36 ± 3% respectively (ns). Ki67 expression by hLE increased from 1.3 ± 0.5% before wounding to 7.89 ± 2.53% post-wounding for hLF- RAFT TEs (p < 0.01), and 0.8 ± 0.08% to 17.68 ± 10.88% for hLF+ RAFT TEs (p < 0.05), suggesting that re-epithelialisation was a result of proliferation. These data suggest that neither airlifting nor hLF are necessarily required to maintain a functional epithelium on RAFT TEs, thus simplifying and shortening the production process. This is important when working towards clinical application of regenerative medicine products.

  5. Human Factors Considerations in New Nuclear Power Plants: Detailed Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    OHara,J.; Higgins, J.; Brown, W.; Fink, R.

    2008-02-14

    This Nuclear Regulatory Commission (NRC) sponsored study has identified human-performance issues in new and advanced nuclear power plants. To identify the issues, current industry developments and trends were evaluated in the areas of reactor technology, instrumentation and control technology, human-system integration technology, and human factors engineering (HFE) methods and tools. The issues were organized into seven high-level HFE topic areas: Role of Personnel and Automation, Staffing and Training, Normal Operations Management, Disturbance and Emergency Management, Maintenance and Change Management, Plant Design and Construction, and HFE Methods and Tools. The issues where then prioritized into four categories using a 'Phenomena Identification and Ranking Table' methodology based on evaluations provided by 14 independent subject matter experts. The subject matter experts were knowledgeable in a variety of disciplines. Vendors, utilities, research organizations and regulators all participated. Twenty issues were categorized into the top priority category. This Brookhaven National Laboratory (BNL) technical report provides the detailed methodology, issue analysis, and results. A summary of the results of this study can be found in NUREG/CR-6947. The research performed for this project has identified a large number of human-performance issues for new control stations and new nuclear power plant designs. The information gathered in this project can serve as input to the development of a long-term strategy and plan for addressing human performance in these areas through regulatory research. Addressing human-performance issues will provide the technical basis from which regulatory review guidance can be developed to meet these challenges. The availability of this review guidance will help set clear expectations for how the NRC staff will evaluate new designs, reduce regulatory uncertainty, and provide a well-defined path to new nuclear power plant

  6. External equivalent type Ward aiming optimization studies in power systems; Equivalentes externos tipo Ward visando estudos de otimizacao em sistemas de potencia

    Energy Technology Data Exchange (ETDEWEB)

    Nepomuceno, Leonardo

    1993-07-01

    The execution of functions such as contingency analysis, optimization, reactive dispatch, etc, at the control centers requires appropriate models representing the non-observable parts (external system). The classical external equivalents have been developed considering basically the contingency analysis. This work points out the performance of the Extended Ward Equivalent (W.E.), which currently represents the state of art concerning reduced circuit based models. the work analyzes the W.E. response to changes occurred in optimization studied. Moreover, a new model, named INTERNAL REACTIVE WARD (WRINT), resulting from an adaptation of the W.E. is proposed focusing on the improvement of the equivalent in case of changes occurs in optimization studies. The model's general idea is to reflect the equivalent's capacity of reactive response into the internal system. Comparative computational test results are shown. The details of routines implementation are also pointed out. (author)

  7. A low power wearable transceiver for human body communication.

    Science.gov (United States)

    Huang, Jin; Chen, Lian-Kang; Zhang, Yuan-Ting

    2009-01-01

    This paper reports a low power transceiver designed for wearable medical healthcare system. Based on a novel energy-efficient wideband wireless communication scheme that uses human body as a transmission medium, the transceiver can achieve a maximum 15 Mbps data rate with total receiver sensitivity of -30 dBm. The chip measures only 0.56 mm(2) and was fabricated in the SMIC 0.18um 1P6M RF CMOS process. The RX consumes 5mW and TX dissipates 1mW with delivering power up to 10uW, which is suitable for the body area network short range application. Real-time medical information collecting through the human body is fully simulated. Architecture of the chip together with the detail characterizes from its wireless analog front-end are presented.

  8. On Equivalence And Evaluation

    Institute of Scientific and Technical Information of China (English)

    孙贝

    2013-01-01

      Equivalence, a central and controversial issue in translation, has been studied, discussed and disputed by many scholars. For this reason, they employed various approaches and have yielded fruitful and remarkable theories. Three representative equivalence theories are selected in the thesis to elaborate equivalence:Nida’s reader-response based dynamic equivalence, Catford’s textual equivalence, Qiu Maoru’s empirical formula on equivalence. Equivalence is an applicable tool to analyze and evaluate translation.

  9. Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents

    DEFF Research Database (Denmark)

    Lottrup, Grete; Belling, Kirstine González-Izarzugaza; Leffers, Henrik

    2017-01-01

    was performed on Agilent whole human genome microarray 4 x 44 K chips. Microarray data pre-processing and statistical analysis were performed using the limma R/Bioconductor package in the R software, and differentially expressed genes were further analysed for gene set enrichment using the DAVID Bioinformatics......STUDY QUESTION: Do human adult Leydig cells (ALCs) within hyperplastic micronodules display characteristics of foetal LCs (FLCs)?SUMMARY ANSWER: The gene expression profiles of FLCs and all ALC subgroups were clearly different, but there were no significant differences in expressed genes between......-section).STUDY DESIGN, SIZE, DURATION: A genome-wide microarray study of LCs microdissected from human foetal and adult tissue samples (n = 12). Additional tissue specimens (n = 15) were used for validation of the mRNA expression data at the protein level.PARTICIPANTS/MATERIALS, SETTING, METHODS: Frozen human tissue...

  10. Documents for Recommended Toxicity Equivalency Factors for Human Health Risk Assessments of Dioxin and Dioxin-Like Compounds

    Science.gov (United States)

    This document describes the U.S. Environmental Protection Agency’s (U.S. EPA’s) updated approach for evaluating the human health risks from exposures to environmental media containing dioxin-like compounds (DLCs).

  11. Development of human resources for Indian nuclear power programme

    Indian Academy of Sciences (India)

    R B Grover; R R Puri

    2013-10-01

    The continuing research and development on nuclear technology by research establishments in the country and maturing of Indian industry have brought the nuclear energy programme in India to a stage where it is poised to take a quantum leap forward. The vision of expansion of nuclear power also requires a wellstructured specialized human resource development programme. This paper discusses the requirements of the human resource development programme for nuclear energy, the challenges in the way of its realization, its national and international status and traces the history of nuclear education in the country. It brings out the linkage of human resource development programme with the nuclear energy programme in the country. It also describes the initiatives by the university system in the area of nuclear education and support provided by the Department of Atomic Energy to the university system by way of extra-mural funding and by providing access to research facilities.

  12. Parsing ERK Activation Reveals Quantitatively Equivalent Contributions From Epidermal Growth Factor Receptor and HER2 In Human Mammary Epithelial Cells

    Energy Technology Data Exchange (ETDEWEB)

    Hendriks, Bart S.; Orr, Galya; Wells, Alan H.; Wiley, H. S.; Lauffenburger, Douglas A.

    2005-02-18

    HER2, a member of the EGFR tyrosine kinase family, functions as an accessory EGFR signaling component and alters EGFR trafficking by heterodimerization. HER2 overexpression leads to aberrant cell behavior including enhanced proliferation and motility. Here we apply a combination of computational modeling and quantitative experimental studies of the dynamic interactions between EGFR and HER2, and their downstream activation of extracellular signal-related kinase (ERK) to understand this complex signaling system. Using cells expressing different levels of HER2 relative to the EGFR, we can separate relative contributions of EGFR and HER2 to signaling amplitude and duration. Based on our model calculations, we demonstrate that, in contrast with previous suggestions in the literature, the intrinsic capabilities of EGFR and HER2 to activated ERK are quantitatively equivalent . We find that HER2-mediated effects on EGFR dimerization and trafficking are sufficient to explain the detected HER2-mediated amplification of EGF-induced ERK signaling. Our model suggests that transient amplification of ERK activity by HER2 arises predominantly from the 2-to-1 stoichiometry of receptor kinase to bound ligand in EGFR/HER2 heterodimers compared to the 1-to-1 stoichiometry of the EGFR homodimer, but alterations in receptor trafficking, with resultant EGFR sparing, cause the sustained HER2-mediated enhancement of ERK signaling.

  13. Cystatin M/E knockdown by lentiviral delivery of shRNA impairs epidermal morphogenesis of human skin equivalents

    NARCIS (Netherlands)

    Jansen, P.A.M.; Bogaard, E.H. van den; Kersten, F.F.J.; Oostendorp, C.; Vlijmen-Willems, I.M. van; Oji, V.; Traupe, H.; Hennies, H.C.; Schalkwijk, J.; Zeeuwen, P.L.J.M.

    2012-01-01

    The protease inhibitor cystatin M/E (CST6) regulates a biochemical pathway involved in stratum corneum homeostasis, and its deficiency in mice causes ichthyosis and neonatal lethality. Cystatin M/E deficiency has not been described in humans so far, and we did not detect disease-causing mutations in

  14. A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents.

    Science.gov (United States)

    Maschmeyer, Ilka; Lorenz, Alexandra K; Schimek, Katharina; Hasenberg, Tobias; Ramme, Anja P; Hübner, Juliane; Lindner, Marcus; Drewell, Christopher; Bauer, Sophie; Thomas, Alexander; Sambo, Naomia Sisoli; Sonntag, Frank; Lauster, Roland; Marx, Uwe

    2015-06-21

    Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substances lack in most in vitro assays. In this study, a microphysiological system maintaining the functionality of four organs over 28 days in co-culture has been established at a minute but standardized microsystem scale. Preformed human intestine and skin models have been integrated into the four-organ-chip on standard cell culture inserts at a size 100,000-fold smaller than their human counterpart organs. A 3D-based spheroid, equivalent to ten liver lobules, mimics liver function. Finally, a barrier segregating the media flow through the organs from fluids excreted by the kidney has been generated by a polymeric membrane covered by a monolayer of human proximal tubule epithelial cells. A peristaltic on-chip micropump ensures pulsatile media flow interconnecting the four tissue culture compartments through microfluidic channels. A second microfluidic circuit ensures drainage of the fluid excreted through the kidney epithelial cell layer. This four-organ-chip system assures near to physiological fluid-to-tissue ratios. In-depth metabolic and gene analysis revealed the establishment of reproducible homeostasis among the co-cultures within two to four days, sustainable over at least 28 days independent of the individual human cell line or tissue donor background used for each organ equivalent. Lastly, 3D imaging two-photon microscopy visualised details of spatiotemporal segregation of the two microfluidic flows by proximal tubule epithelia. To our knowledge, this study is the first approach to establish a system for in vitro microfluidic ADME profiling and repeated dose systemic toxicity testing of drug candidates over 28 days.

  15. The study of equivalent dose of uranium in long bean (V. U. Sesquipedalis) and the effect on human

    Energy Technology Data Exchange (ETDEWEB)

    Rashid, Nur Shahidah Abdul; Yoshandi, Tengku Mohammad; Majid, Sukiman Sarmania Amran Ab.; Mohamed, Faizal; Siong, Khoo Kok, E-mail: khoo@ukm.edu.my [School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), 43600 Bangi, Selangor (Malaysia)

    2016-01-22

    In the case of accidental release of Uranium-238 ({sup 238}U) radionuclides in a nuclear facility or in the environment, internal contamination by either acute or chronic exposure has the potential to induce both radiological and chemical toxic effects. A study was conducted to estimate the {sup 238}U radionuclide concentration in the long beans using Induced Coupled Mass Plasma-Spectrometry (ICP-MS). {sup 238}U radionuclide is a naturally occurring radioactive material that can be found in soil and can be transferred to the long bean (Vigna unguiculata subsp. Sesquapedalis) directly or indirectly via water or air. Kidney and liver are the major sites of deposition of {sup 238}U radionuclide. The obtained dose exposed in the liver and kidney is used to assess the safety level for public intake of {sup 238}U radionuclide from the consumption of long beans. The concentration of {sup 238}U radionuclide measured in long bean samples was 0.0226 ± 0.0009 mg/kg. Total activity of {sup 238}U radionuclide was 0.0044 ± 0.0002 Bq/day with the daily intake of 0.3545 ± 0.0143 µg/day and the annual committed effective dose due to ingestion of {sup 238}U radionuclide in long beans was 0.2230 ± 0.0087 µSv/year. The committed equivalent dose of {sup 238}U radionuclide from the assessment in the liver and kidney are 0.4198 ± 0.0165 nSv and 10.9335 ± 0.4288 nSv. The risk of cancer of {sup 238}U radionuclide was determined to be (86.0466 ± 3.3748) × 10-9. Thus, the results concluded that {sup 238}U radionuclide in local long beans was in the permitted level and safe to consume without posing any significant radiological threat to population.

  16. The study of equivalent dose of uranium in long bean (V. U. Sesquipedalis) and the effect on human

    Science.gov (United States)

    Rashid, Nur Shahidah Abdul; Yoshandi, Tengku Mohammad; Majid, Sukiman Sarmania Amran Ab.; Mohamed, Faizal; Siong, Khoo Kok

    2016-01-01

    In the case of accidental release of Uranium-238 (238U) radionuclides in a nuclear facility or in the environment, internal contamination by either acute or chronic exposure has the potential to induce both radiological and chemical toxic effects. A study was conducted to estimate the 238U radionuclide concentration in the long beans using Induced Coupled Mass Plasma-Spectrometry (ICP-MS). 238U radionuclide is a naturally occurring radioactive material that can be found in soil and can be transferred to the long bean (Vigna unguiculata subsp. Sesquapedalis) directly or indirectly via water or air. Kidney and liver are the major sites of deposition of 238U radionuclide. The obtained dose exposed in the liver and kidney is used to assess the safety level for public intake of 238U radionuclide from the consumption of long beans. The concentration of 238U radionuclide measured in long bean samples was 0.0226 ± 0.0009 mg/kg. Total activity of 238U radionuclide was 0.0044 ± 0.0002 Bq/day with the daily intake of 0.3545 ± 0.0143 µg/day and the annual committed effective dose due to ingestion of 238U radionuclide in long beans was 0.2230 ± 0.0087 µSv/year. The committed equivalent dose of 238U radionuclide from the assessment in the liver and kidney are 0.4198 ± 0.0165 nSv and 10.9335 ± 0.4288 nSv. The risk of cancer of 238U radionuclide was determined to be (86.0466 ± 3.3748) × 10-9. Thus, the results concluded that 238U radionuclide in local long beans was in the permitted level and safe to consume without posing any significant radiological threat to population.

  17. The design of a human-powered vehicle

    Science.gov (United States)

    Wiederholt, J. V.; Pahle, J. W.

    1983-01-01

    Human power applied through a bicycle is perhaps the most efficient means of transport available today. Aerodynamic drag, however, limits the speed possible from the man/bicycle combination. An aerodynamically efficient body enclosing the system can reduce the drag and permit increased speeds. A study was conducted to determine an efficient body design for a high-speed bicycle. Wind tunnel and potential flow studies were conducted to evaluate the drag and lift characteristics of proposed shell designs. A proposed bicycle/shell design is presented.

  18. Effective atomic numbers, water and tissue equivalence properties of human tissues, tissue equivalents and dosimetric materials for total electron interaction in the energy region 10 keV-1 GeV.

    Science.gov (United States)

    Kurudirek, Murat

    2014-12-01

    Effective atomic numbers (Zeff) of 107 different materials of dosimetric interest have been calculated for total electron interactions in the wide energy region 10keV-1GeV. The stopping cross sections of elements and dosimetric materials were used to calculate Zeff of the materials. Differences (%) in Zeff relative to water have been calculated in the entire energy region to evaluate the water equivalency of the used materials. Moreover, the tissue equivalent materials have been compared with the tissues and dosimetric materials in terms of Zeff to reveal their ability to use as tissue substitutes. Possible conclusions were drawn based on the variation of Zeff through the entire energy region and water and tissue equivalency comparisons in terms of Zeff. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Mutations in AAC2, equivalent to human adPEO-associated ANT1 mutations, lead to defective oxidative phosphorylation in Saccharomyces cerevisiae and affect mitochondrial DNA stability.

    Science.gov (United States)

    Fontanesi, Flavia; Palmieri, Luigi; Scarcia, Pasquale; Lodi, Tiziana; Donnini, Claudia; Limongelli, Anna; Tiranti, Valeria; Zeviani, Massimo; Ferrero, Iliana; Viola, Anna Maria

    2004-05-01

    Autosomal dominant and recessive forms of progressive external ophthalmoplegia (adPEO and arPEO) are mitochondrial disorders characterized by the presence of multiple deletions of mitochondrial DNA in affected tissues. Four adPEO-associated missense mutations have been identified in the ANT1 gene. In order to investigate their functional consequences on cellular physiology, we introduced three of them at equivalent positions in AAC2, the yeast orthologue of human ANT1. We demonstrate here that expression of the equivalent mutations in aac2-defective haploid strains of Saccharomyces cerevisiae results in (a) a marked growth defect on non-fermentable carbon sources, and (b) a concurrent reduction of the amount of mitochondrial cytochromes, cytochrome c oxidase activity and cellular respiration. The efficiency of ATP and ADP transport was variably affected by the different AAC2 mutations. However, irrespective of the absolute level of activity, the AAC2 pathogenic mutants showed a significant defect in ADP versus ATP transport compared with wild-type AAC2. In order to study whether a dominant phenotype, as in humans, could be observed, the aac2 mutant alleles were also inserted in combination with the endogenous wild-type AAC2 gene. The heteroallelic strains behaved as recessive for oxidative growth and petite-negative phenotype. In contrast, reduction in cytochrome content and increased mtDNA instability appeared to behave as dominant traits in heteroallelic strains. Our results indicate that S. cerevisiae is a suitable in vivo model to study the pathogenicity of the human ANT1 mutations and the pathophysiology leading to impairment of oxidative phosphorylation and damage of mtDNA integrity, as found in adPEO.

  20. The transnational ne bis in idem principle in the EU. Mutual recognition and equivalent protection of human rights

    Directory of Open Access Journals (Sweden)

    John A.E. Vervaele

    2005-12-01

    Full Text Available The deepening and widening of European integration has led to an increase in transborder crime. Concurrent prosecution and sanctioning by several Member States is not only a problem in inter-state relations and an obstacle in the European integration process, but also a violation of the ne bis in idem principle, defined as a transnational human right in a common judicial area. This article analyzes whether and to what extent the ECHR has contributed and may continue to contribute to the development of such a common ne bis in idem standard in Europe. It is also examined whether the application of the ne bis in idem principle in classic inter-state judicial cooperation in criminal matters in the framework of the Council of Europe may make such a contribution as well. The transnational function of the ne bis in idem principle is discussed in the light of the Court of Justice’s case law on ne bis in idem in the framework of the area of Freedom, Security and Justice. Finally the inherent tension between mutual recognition and the protection of human rights in transnational justice is analyzed by looking at the insertion of the ne bis in idem principle in the Framework Decision on the European arrest warrant.

  1. Derived equivalence of algebras

    Institute of Scientific and Technical Information of China (English)

    杜先能

    1997-01-01

    The derived equivalence and stable equivalence of algebras RmA and RmB are studied It is proved, using the tilting complex, that RmA and RmB are derived-equivalent whenever algebras A and B are derived-equivalent

  2. Can biophysics tell us something about the weak equivalence principle vis a vis the thought experiment of Einstein involving human subjects?

    Science.gov (United States)

    Thaheld, Fred H

    2009-08-01

    Over a period of several decades it has been noticed that most astronauts, either orbiting the earth or on trips to the moon, have observed phosphenes or light flashes (LF) including streaks, spots and clouds of light when their eyes are closed or they are in a darkened cabin. Scientists suspect that two separate components of cosmic rays cause these flashes due to direct interaction with the retina. This phenomenon is not noticed on the ground because of cosmic ray interaction with the atmosphere. The argument is advanced that this effect may provide us with a new method of exploring the weak equivalence principle from the standpoint of Einstein's original thought experiment involving human subjects. This can be done, utilizing the retina only, as an animate quantum mechanical measuring device or, in conjunction with the Anomalous Long Term Effects on Astronauts (ALTEA) facility.

  3. 77 FR 60985 - Ambient Air Monitoring Reference and Equivalent Methods: Designation of Three New Equivalent Methods

    Science.gov (United States)

    2012-10-05

    ... AGENCY Ambient Air Monitoring Reference and Equivalent Methods: Designation of Three New Equivalent... methods for monitoring ambient air quality. SUMMARY: Notice is hereby given that the Environmental... in the ambient air. FOR FURTHER INFORMATION CONTACT: Robert Vanderpool, Human Exposure...

  4. Bryostatin and its synthetic analog, picolog rescue dermal fibroblasts from prolonged stress and contribute to survival and rejuvenation of human skin equivalents.

    Science.gov (United States)

    Khan, Tapan K; Wender, Paul A; Alkon, Daniel L

    2017-06-07

    Skin health is associated with the day-to-day activity of fibroblasts. The primary function of fibroblasts is to synthesize structural proteins, such as collagen, extracellular matrix proteins, and other proteins that support the structural integrity of the skin and are associated with younger, firmer, and more elastic skin that is better able to resist and recover from injury. At sub-nanomolar concentrations (0.03-0.3 nM), bryostatin-1 and its synthetic analog, picolog (0.1-10 nM) sustained the survival and activation of human dermal fibroblasts cultured under the stressful condition of prolonged serum deprivation. Bryostatin-1 treatment stabilized human skin equivalents (HSEs), a bioengineered combination of primary human skin cells (keratinocytes and dermal fibroblasts) on an extracellular matrix composed of mainly collagen. Fibroblasts activated by bryostatin-1 protected the structural integrity of HSEs. Bryostatin-1 and picolog prolonged activation of Erk in fibroblasts to promote cell survival. Chronic stress promotes the progression of apoptosis. Dermal fibroblasts constitutively express all components of Fas associated apoptosis, including caspase-8, an initiator enzyme of apoptosis. Prolong bryostatin-1 treatment reduced apoptosis by decreasing caspase-8 and protected dermal fibroblasts. Our data suggest that bryostatin-1 and picolog could be useful in anti-aging skincare, and could have applications in tissue engineering and regenerative medicine. © 2017 Wiley Periodicals, Inc.

  5. Review on External System Equivalent Method for Electromagnetic Transient Simulation of Power Systems%电力系统电磁暂态仿真外部系统等值方法综述

    Institute of Scientific and Technical Information of China (English)

    林济铿; 闫贻鹏; 刘涛; 郑卫洪

    2012-01-01

    对实际电力系统进行电磁暂态仿真,往往耗时很长。如何有效地对外部系统进行等值以减小仿真系统的规模,长期以来是电磁暂态仿真研究领域中的一个重要课题。对该领域迄今为止主要外部系统等值方法进行了分类,给出了各类方法的基本过程,分析了其优缺点;并对该领域今后的发展趋势及关键问题的突破作了展望。%Electromagnetic transient simulation of an actual large-scale power system usually takes long time. How to achieve the equivalent circuit for the external system and reduce the simulation system scale has all long been one of the key topics in the field of electromagnetic transient simulation. So far the main external system equivalent methods in this field are classified, and the main content and process of each method and its advantages and disadvantages are described and analyzed. Finally, a look-ahead for the development tendency and the key issues of the external system equivalent methods to be broken through for power system electromagnetic transient simulation are presented.

  6. Politico-economic equivalence

    DEFF Research Database (Denmark)

    Gonzalez Eiras, Martin; Niepelt, Dirk

    2015-01-01

    Traditional "economic equivalence'' results, like the Ricardian equivalence proposition, define equivalence classes over exogenous policies. We derive "politico-economic equivalence" conditions that apply in environments where policy is endogenous and chosen sequentially. A policy regime...... and a state are equivalent to another such pair if both pairs give rise to the same allocation in politico-economic equilibrium. The equivalence conditions help to identify factors that render institutional change non-neutral and to construct politico-economic equilibria in new policy regimes. We exemplify...... their use in the context of several applications, relating to social security reform, tax-smoothing policies and measures to correct externalities....

  7. Thirst for Power: Energy, Water and Human Survival

    Science.gov (United States)

    Webber, M.

    2015-12-01

    Energy and water are precious resources, and they are interconnected. The energy sector uses a lot of water -- the thermoelectric power sector alone is the largest user of water in the U.S., withdrawing 200 billion gallons daily for powerplant cooling. Conversely, the water sector is responsible for over twelve percent of national energy consumption for moving, pumping, treating, and heating water. This interdependence means that droughts can cause energy shortages, and power outages can bring the water system to a halt. It also means that water efficiency is a pathway to energy efficiency and vice versa. This talk will give a big-picture overview of global energy and water trends to describe how they interact, what conflicts are looming, and how they can work together. This talk will include the vulnerabilities and cross-cutting solutions such as efficient markets and smart technologies that embed more information about resource management. It will include discussion of how population growth, economic growth, climate change, and short-sighted policies are likely to make things worse. Yet, more integrated planning with long-term sustainability in mind along with cultural shifts, advanced technologies, and better design can avert such a daunting future. Combining anecdotes and personal stories with insights into the latest science of energy and water, this talk will identify a hopeful path toward wise, long-range water-energy decisions and a more reliable and abundant future for humanity.

  8. Maximum Power Point Tracking Control in the Photovoltaic Power Generation Based on Dynamic Equivalent Impedance Matching Theory%基于动态等效阻抗匹配的光伏发电最大功率点跟踪控制

    Institute of Scientific and Technical Information of China (English)

    郑颖楠; 王俊平; 张霞

    2011-01-01

    A new method which can linearize the nonlinear internal impedance was proposed. Based on the concept of dynamic equivalent impedance error, the engineering significance of dynamic equivalent impedance matching and the validity of dynamic equivalent impedance error control method were discussed. According to the thought of equivalent impedance matching, the self-optimizing maximum power point tracking (MPPT) control structure and algorithm in the photovoltaic power generation were developed, which can be achieved by digital. The experimental results show that the dynamic equivalent impedance matching algorithm has more obvious advantages, compared with the classic MPPT control algorithms.%提出1种非线性内阻抗的线性化处理方法.基于动态等效阻抗误差的概念,论述动态等效阻抗适配的L程意义:阐述动态等效阻抗误差控制的有效性.根据等效阻抗适配思想,构造出数字实现的光伏发电最大功率点跟踪(maximum power point tracking,MPPT)自寻优控制系统结构和算法.最后的实验结果证明,与几种经典MPPT控制算法相比,动态等效阻抗匹配控制算法具有更明显的优点.

  9. Technical advance: Generation of human pDC equivalents from primary monocytes using Flt3-L and their functional validation under hypoxia.

    Science.gov (United States)

    Sekar, Divya; Brüne, Bernhard; Weigert, Andreas

    2010-08-01

    The division of labor between DC subsets is evolutionarily well-defined. mDC are efficient in antigen presentation, whereas pDC act as rheostats of the immune system. They activate NK cells, cause bystander activation of mDC, and interact with T cells to induce tolerance. This ambiguity positions pDC at the center of inflammatory diseases, such as cancer, arthritis, and autoimmune diseases. The ability to generate human mDC ex vivo made it possible to engineer them to suit therapy needs. Unfortunately, a similar, easily accessible system to generate human pDC is not available. We describe a method to generate human pDC equivalents ex vivo, termed mo-pDC from peripheral blood monocytes using Flt3-L. mo-pDC showed a characteristic pDC profile, such as high CD123 and BDCA4, but low CD86 and TLR4 surface expression and a low capacity to induce autologous lymphocyte proliferation and to phagocytose apoptotic debris in comparison with mDC. Interestingly, mo-pDC up-regulated the pDC lineage-determining transcription factor E2-2 as well as expression of BDCA2, which is under the transcriptional control of E2-2 but not its inhibitor ID2, during differentiation. mo-pDC produced high levels of IFN-alpha when pretreated overnight with TNF-alpha. Under hypoxia, E2-2 was down-regulated, and ID2 was induced in mo-pDC, whereas surface expression of MHCI, CD86, and BDCA2 was decreased. Furthermore, mo-pDC produced high levels of inflammatory cytokines when differentiated under hypoxia compared with normoxia. Hence, mo-pDC can be used to study differentiation and functions of human pDC under microenvironmental stimuli.

  10. 面向综合负荷的并网光伏发电系统等效建模%Equivalent Modeling of Grid-connected Photovoltaic Power Generation Systems for Comprehensive Load

    Institute of Scientific and Technical Information of China (English)

    李培强; 曾小军; 黄际元; 童莹; 张晓敏; 张立

    2016-01-01

    A simulation system for the grid-connected photovoltaic (PV) power generation system is developed based on the MATLAB/Simulink and the physical mechanism of the PV cells.The influence of the grid-connected PV power generation system on the comprehensive load characteristic of distribution network is studied.And several equivalent models available to the PV power generation system are analyzed and compared.On this basis,a new equivalent model based on transfer functions for the PV power generation system is proposed.The model has a simple structure,less parameters,and can effectively describe the output limit of PV power generation system.At the same time,it is easy to implement in the power system simulation software.A generalized comprehensive load model is developed by paralleling the conventional comprehensive load model with the new equivalent model to describe the characteristic of the comprehensive load containing PV power generation systems.Simulation results show that the generalized comprehensive load model has good generalization ability and stable identification parameters,while meeting the need of engineering simulation.%基于 MATLAB/Simulink 和光伏电池自身的物理机理搭建了并网光伏发电的仿真系统,研究了其对配电网综合负荷特性的影响因素,分析比较了已有光伏发电系统等效模型的优劣。在此基础上构建了光伏发电系统传递函数等效模型,该模型具有结构简单、参数少、能有效描述光伏发电系统的出力极限等优点,同时易于在电力系统仿真软件中实现。采用所提出的等效模型与传统综合负荷模型并联,构建广义综合负荷模型,对含光伏发电系统的综合负荷进行建模,仿真实践表明此广义综合负荷模型具有良好的泛化能力,辨识参数稳定,能够满足工程仿真的需要。

  11. Comparison between the calculated and measured dose distributions for four beams of 6 MeV linac in a human-equivalent phantom

    Directory of Open Access Journals (Sweden)

    Reda Sonia M.

    2006-01-01

    Full Text Available Radiation dose distributions in various parts of the body are of importance in radiotherapy. Also, the percent depth dose at different body depths is an important parameter in radiation therapy applications. Monte Carlo simulation techniques are the most accurate methods for such purposes. Monte Carlo computer calculations of photon spectra and the dose ratios at surfaces and in some internal organs of a human equivalent phantom were performed. In the present paper, dose distributions in different organs during bladder radiotherapy by 6 MeV X-rays were measured using thermoluminescence dosimetry placed at different points in the human-phantom. The phantom was irradiated in exactly the same manner as in actual bladder radiotherapy. Four treatment fields were considered to maximize the dose at the center of the target and minimize it at non-target healthy organs. All experimental setup information was fed to the MCNP-4b code to calculate dose distributions at selected points inside the proposed phantom. Percent depth dose distribution was performed. Also, the absorbed dose as ratios relative to the original beam in the surrounding organs was calculated by MCNP-4b and measured by thermoluminescence dosimetry. Both measured and calculated data were compared. Results indicate good agreement between calculated and measured data inside the phantom. Comparison between MCNP-4b calculations and measurements of depth dose distribution indicated good agreement between both.

  12. Technical advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration.

    Science.gov (United States)

    Ouwehand, Krista; Spiekstra, Sander W; Waaijman, Taco; Scheper, Rik J; de Gruijl, Tanja D; Gibbs, Susan

    2011-11-01

    In this report, the construction of a functional, immunocompetent, full-thickness skin equivalent (SE) is described, consisting of an epidermal compartment containing keratinocytes, melanocytes, and human LCs derived from the MUTZ-3 cell line (MUTZ-LC) and a fibroblast-populated dermal compartment. The CD1a(+)Langerin(+)HLA-DR(+) MUTZ-LCs populate the entire epidermis at a similar density to that found in native skin. Exposure of the SE to subtoxic concentrations of the allergens NiSO(4) and resorcinol resulted in LC migration out of the epidermis toward the fibroblast-populated dermal compartment. A significant dose-dependent up-regulation of the DC maturation-related CCR7 and IL-1β transcripts and of CD83 at the protein level upon epidermal exposure to both allergens was observed, indicative of maturation and migration of the epidermally incorporated LC. We have thus successfully developed a reproducible and functional full-thickness SE model containing epidermal MUTZ-LC. This model offers an alternative to animal testing for identifying potential chemical sensitizers and for skin-based vaccination strategies and provides a unique research tool to study human LC biology in situ under controlled in vitro conditions.

  13. Robotic Powered Transfer Mechanism modeling on Human Muscle Structure

    Science.gov (United States)

    Saito, Yukio

    It is considered in engineering that one power source can operate one joint. However, support movement mechanism of living organism is multi joint movement mechanism. Considerably different from mechanical movement mechanism, two pairs of uni-articular muscles and a pair of bi-articular muscles are involved in it. In leg, movements observed in short run including leg idling, heel contact and toeing are operated by bi-articular muscles of the thigh showing strong legs to support body weight. Pursuit of versatility in welfare robot brings its comparison with conventional machinery or industrial robot to the fore. Request for safety and technology allowing elderly people to operate the robot is getting stronger in the society. The robot must be safe when it is used together with other welfare equipment and simpler system avoiding difficult operation has to be constructed. Appearance of recent care and assistance robot is getting similar to human arm in comparison with industrial robot. Being easily able to imagine from industrial robot, mid-heavyweight articulated robot to support 60-70kgf combined with large output motor and reduction gears is next to impossible to be installed in the bath room. This research indicated that upper limb arm and lower limb thigh of human and animals are holding coalitional muscles and movement of uni-artcular muscle and bi-articular muscle conjure the image of new actuators.

  14. The upper limit of aerobic power in humans.

    Science.gov (United States)

    Burtscher, Martin; Nachbauer, Werner; Wilber, Randall

    2011-10-01

    Data on the upper limit of aerobic power in humans are scarce. Thus, here we demonstrate extraordinarily high V'O(2)max and submaximal exercise performance in a young elite cross country skier (22 years, 170 cm, 63 kg; hemoglobin: 16.8 g/dL) who was evaluated before winning an Olympic gold medal. The test was performed during progressive roller-ski exercise on an outdoor uphill track (7-10% incline). The athlete demonstrated a V'O(2)max of 90.6 mL/min/kg (45 s average; 26 METs; 5.7 L/min). But even more impressive than V'O(2)max was his ability to exercise at a V'O(2) of 65 mL/min/kg (71.4% V'O(2)max) at a lactate level of 1.6 mmol/L. At the self-selected maximal lactate steady state he consumed 78 mLO(2)/min/kg (85.7% V'O(2)max) with a corresponding lactate level of 4.4 mmol/L. These values rank among the highest ever demonstrated in human beings.

  15. Feasibility Analysis and Simulation of a Stand-Alone Photovoltaic Energy System for Electricity Generation and Environmental Sustainability – equivalent to 650VA fuel-powered generator - popularly known as I pass my neighbour

    Directory of Open Access Journals (Sweden)

    Vincent Anayochukwu Ani

    2015-09-01

    Full Text Available Photovoltaic (PV power system can be used to replace wholly 650VA generator for electricity generation for household use in Nigeria. This paper presented the feasibility analysis of load data and simulation study of a stand-alone PV power system that produced the electrical needs of a household. This study is based on designing of PV energy system for household use. The patterns of load consumption within the household were studied and suitably modeled for simulation. The simulation study indicates that energy requirements to provide electricity which is equivalent to 650VA generator for household use in Nigeria can be accomplished by 520W solar PV array, 2312 Ah nominal capacity battery, and a 1kW DC/AC inverter. This would be suitable for deployment of 100% clean energy for environmental sustainability and uninterruptable power performance in the household. The results of this research show that, with a low-power consuming appliances, it is possible to meet the entire annual electricity demand of a single household solely through a stand-alone PV energy supply. Installing solar panels by most Nigerian home can significantly reduce home reliance on government power thereby reduce the strain on the current capacity of our power generation infrastructure. A detailed design and description of the system were presented in this paper.

  16. Equivalence principles and electromagnetism

    Science.gov (United States)

    Ni, W.-T.

    1977-01-01

    The implications of the weak equivalence principles are investigated in detail for electromagnetic systems in a general framework. In particular, it is shown that the universality of free-fall trajectories (Galileo weak equivalence principle) does not imply the validity of the Einstein equivalence principle. However, the Galileo principle plus the universality of free-fall rotation states does imply the Einstein principle.

  17. Equivalence in Translation

    Institute of Scientific and Technical Information of China (English)

    李良杰

    2013-01-01

    There are many researches about translation theories and methods in western translation history. Equivalence in transla⁃tion has always been the central issue for discussion. This paper gives a general review and comment on equivalence in translation in terms of three representative translation theorists and their views about equivalence in translation.

  18. Building the fastest bicycle in the world; a year with the Human Power Team Delft & Amsterdam

    NARCIS (Netherlands)

    Schuurman, M.; Roks, G.

    2014-01-01

    “Third time lucky” is the saying, but for the third Human Power Team it almost turned out as a year for nothing. The team has been attempting to set the world record for the fastest bicycle powered only by human muscles for two years already. This endeavor to let a Dutchman be the fastest human on e

  19. Characterization of a human powered nebulizer compressor for resource poor settings.

    Science.gov (United States)

    Hallberg, Christopher J; Lysaught, Mary Therese; Zmudka, Christopher E; Kopesky, William K; Olson, Lars E

    2014-06-16

    Respiratory disease accounts for three of the ten leading causes of death worldwide. Many of these diseases can be treated and diagnosed using a nebulizer. Nebulizers can also be used to safely and efficiently deliver vaccines. Unfortunately, commercially available nebulizers are not designed for use in regions of the world where lung disease is most prevalent: they are electricity-dependent, cost-prohibitive, and not built to be reliable in harsh operating conditions or under frequent use.To overcome these limitations, the Human Powered Nebulizer compressor (HPN) was developed. The HPN does not require electricity; instead airflow is generated manually through a hand-crank or bicycle-style pedal system. A health care worker or other trained individual operates the device while the patient receives treatment.This study demonstrates functional specifications of the HPN in comparison with a standard commercially available electric jet nebulizer compressor, the DeVilbiss Pulmo-Aide 5650D (Pulmo-Aide). Pressure and flow characteristics were measured with a rotameter and pressure transducer, respectively. Volume nebulized by each compressor was determined by mass, and particle size distribution was determined via laser diffraction. The Hudson RCI Micro Mist nebulizer mouthpiece was used with both compressors. The pressure and flow generated by the HPN and Pulmo-Aide were: 15.17 psi and 10.5 L/min; and 14.65 psi and 11.2 L/min, respectively. The volume of liquid delivered by each was equivalent, 1.097 ± 0.107 mL (mean ± s.e.m., n = 13) for the HPN and 1.092 ± 0.116 mL for the Pulmo-Aide. The average particle size was also equivalent, 5.38 ± 0.040 micrometers (mean ± s.e.m., n = 7) and 5.40 ± 0.025 micrometers, respectively. Based on these characteristics, the HPN's performance is equivalent to a popular commercially available electric nebulizer compressor. The findings presented in this paper, combined with the results of two

  20. Power Transfer to a Human during an Electric Eel's Shocking Leap.

    Science.gov (United States)

    Catania, Kenneth C

    2017-09-25

    Electric eels have been the subject of investigation and curiosity for centuries [1]. They use high voltage to track [2] and control [3] prey, as well as to exhaust prey by causing involuntary fatigue through remote activation of prey muscles [4]. But their most astonishing behavior is the leaping attack, during which eels emerge from the water to directly electrify a threat [5, 6]. This unique defense has reportedly been used against both horses [7] and humans [8]. Yet the dynamics of the circuit that develops when a living animal is contacted and the electrical power transmitted to the target have not been directly investigated. In this study, the electromotive force and circuit resistances that develop during an eel's leaping behavior were determined. Next, the current that passed through a human subject during the attack was measured. The results allowed each variable in the equivalent circuit to be estimated. Findings can be extrapolated to a range of different eel sizes that might be encountered in the wild. Despite the comparatively small size of the eel used in this study, electrical currents in the target peaked at 40-50 mA, greatly exceeding thresholds for nociceptor activation reported for both humans [9] and horses [10, 11]. No subjective sensation of involuntary tetanus was reported, and aversive sensations were restricted to the affected limb. Results suggest that the main purpose of the leaping attack is to strongly deter potential eel predators by briefly causing intense pain. Apparently a strong offense is the eel's best defense. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  1. Thirst for Power: Energy, Water and Human Survival

    Science.gov (United States)

    Webber, M.

    2016-12-01

    Energy, food and water are precious resources, and they are interconnected. The energy sector uses a lot of water, the food sector uses a lot of energy and water, the water sector uses a lot of energy, and as a nation we are contemplating a biofuels policy that uses food for energy. The thermoelectric power sector alone is the largest user of water in the U.S., withdrawing 200 billion gallons daily for powerplant cooling. Conversely, the water sector is responsible for over twelve percent of national energy consumption for moving, pumping, treating, and heating water. The food system uses over ten percent of national energy consumption. This interdependence means that droughts can cause energy shortages, and power outages can bring the water system to a halt, while energy and water challenges pose constraints to our food system. It also means that water efficiency is a pathway to energy efficiency and vice versa. This talk will give a big-picture overview of global food, energy and water trends to describe how they interact, what conflicts are looming, and how they can work together. This talk will include the vulnerabilities and cross-cutting solutions such as efficient markets and smart technologies that embed more information about resource management. It will include discussion of how population growth, economic growth, climate change, and short-sighted policies are likely to make things worse. Yet, more integrated planning with long-term sustainability in mind along with cultural shifts, advanced technologies, and better design can avert such a daunting future. Combining anecdotes and personal stories with insights into the latest science of energy and water, this talk will identify a hopeful path toward wise, long-range water-energy decisions and a more reliable and abundant future for humanity.

  2. Research on Equivalence of Induction Motors During Plant Power Supply Switching%模拟厂用电源切换的感应电动机群等值研究

    Institute of Scientific and Technical Information of China (English)

    徐晓燕; 孙竞瑜

    2011-01-01

    During plant power supply switching, the voltage on bus goes through decaying to recovering, while impulse current occurs in line during this process, which affects the switching of plant power supply. Based on the characteristic of the voltage on bus and inrush current, induction motors is divided into grouping by considering dynamic stability of induction motor. Then, each group is taken as one equivalent induction motor, both of which have same power loss. In the end, the simulation is carried out in EMTDC. The results show that equivalent simplified model is suitable for three kinds of modes of plant power supply switching.%厂用电源切换过程中,母线电压经历一个从衰减到恢复的过程,线路在切换中则会产生冲击电流,母线电压和线路电流的变化影响着厂用电源切换成功与否.本文基于厂用电源切换过程中母线电压和冲击电流的特点,计及感应电动机的动态稳定特性,将感应电动机群分组,然后将每一组的感应电动机群等值成一台感应电动机,等值前后的感应电动机具有相同的功率消耗.最后针对一个厂用电系统,利用EMTDC软件进行仿真研究.结果表明,等值后的简化模型对于3种厂用电切换方式均适用.

  3. Improving human reliability through better nuclear power plant system design: Program for advanced nuclear power studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Golay, M.W.

    1993-10-10

    The project on ``Development of a Theory of the Dependence of Human Reliability upon System Designs as a Means of Improving Nuclear Power Plant Performance`` was been undertaken in order to address the problem of human error in advanced nuclear power plant designs. Lack of a mature theory has retarded progress in reducing likely frequencies of human errors. Work being pursued in this project is to perform a set of experiments involving human subjects who are required to operate, diagnose and respond to changes in computer-simulated systems, relevant to those encountered in nuclear power plants, which are made to differ in complexity in a systematic manner. The computer program used to present the problems to be solved also records the response of the operator as it unfolds.

  4. Permeation and metabolism of a novel ascorbic acid derivative, disodium isostearyl 2-O-L-ascorbyl phosphate, in human living skin equivalent models.

    Science.gov (United States)

    Shibayama, H; Hisama, M; Matsuda, S; Ohtsuki, M

    2008-01-01

    A novel amphiphilic vitamin C (VC) derivative, disodium isostearyl 2-O-L-ascorbyl phosphate (VCP-IS-2Na), which possesses a C(18) alkyl chain attached to a stable ascorbate derivative, sodium L-ascorbic acid 2-phosphate (VCP-Na), was evaluated as a topical prodrug of VC with transdermal activity in human living skin equivalent (LSE) models. The permeation assay used was EPI-606X in the Franz-type diffusion cell system. VCP-IS-2Na exhibited much better permeability than VC and VCP-Na. The accumulation assays applied were EPI-200X and LSE-high by the dynamic system. The increased skin accumulation of VCP-IS-2Na was superior to that of VCP-Na and VC. VCP-IS-2Na that is susceptible to enzymatic hydrolysis by esterase and/or phosphatase released VC in the skin. Measurement of the metabolites that permeated and accumulated from the skin model suggested that VCP-IS-2Na was mainly metabolized via VCP-Na to VC in EPI-606X and EPI-200X, while it was mainly metabolized directly to VC in TESTSKIN LSE-high. Thus, these characteristics indicate that the novel VC derivative, VCP-IS-2Na, may be advantageous as a readily available source of VC for skin care applications.

  5. Moderate alcohol exposure during the rat equivalent to the third trimester of human pregnancy alters dopamine regulation of GABAA receptor-mediated transmission in the basolateral amygdala

    Directory of Open Access Journals (Sweden)

    Marvin Rafael Diaz

    2014-05-01

    Full Text Available Fetal ethanol (EtOH exposure leads to a range of neurobehavioral alterations, including deficits in emotional processing. The basolateral amygdala (BLA plays a critical role in modulating emotional processing, in part, via dopamine (DA regulation of GABA transmission. This BLA modulatory system is acquired during the first two weeks of postnatal life in rodents (equivalent to the 3rd trimester of human pregnancy and we hypothesized that it could be altered by EtOH exposure during this period. We found that exposure of rats to moderate levels of EtOH vapor during the 3rd trimester-equivalent (postnatal days (P 2-12 alters DA modulation of GABAergic transmission in BLA pyramidal neurons during periadolescence. Specifically, D1R-mediated potentiation of spontaneous inhibitory postsynaptic currents (IPSCs was significantly attenuated in EtOH-exposed animals. However, this was associated with a compensatory decrease in D3R-mediated suppression of miniature IPSCs. Western blot analysis revealed that these effects were not a result of altered D1R or D3R levels. BLA samples from EtOH-exposed animals also had significantly lower levels of the DA precursor (L-3,4-dihydroxyphenylalanine but DA levels were not affected. This is likely a consequence of reduced catabolism of DA, as indicated by reduced levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the BLA samples. Anxiety-like behavior was not altered in EtOH-exposed animals. This is the first study to demonstrate that the modulatory actions of DA in the BLA are altered by developmental EtOH exposure. Although compensatory adaptations were engaged in our moderate EtOH exposure paradigm, it is possible that these are not able to restore homeostasis and correct anxiety-like behaviors under conditions of heavier EtOH exposure. Therefore, future studies should investigate the potential role of alterations in the modulatory actions of DA in the pathophysiology of fetal alcohol spectrum

  6. Power, trust, and Science of Unitary Human Beings influence political leadership: a celebration of Barrett's power theory.

    Science.gov (United States)

    Wright, Barbara W

    2010-01-01

    The importance of nurses' participation in health policy leadership is discussed within the context of Rogers' science of unitary human beings, Barrett's power theory, and one nurse-politician's experience. Nurses have a major role to play in resolving public policy issues that influence the health of people. A brief review of the history of nurses in the political arena is presented. Research related to power and trust is reviewed. Suggested strategies for success in political situations are offered.

  7. The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection

    NARCIS (Netherlands)

    L.E. Coffeng (Luc); C.C. Hermsen (Cornelus); R.W. Sauerwein (Robert); S.J. de Vlas (Sake)

    2017-01-01

    textabstractControlled human malaria infection (CHMI) in healthy human volunteers is an important and powerful tool in clinical malaria vaccine development. However, power calculations are essential to obtain meaningful estimates of protective efficacy, while minimizing the risk of adverse events.

  8. Wind power effects on human interests. A synthesis report; Vindkraftens paaverkan paa maenniskors intressen. En syntesrapport

    Energy Technology Data Exchange (ETDEWEB)

    Bengtsson Ryberg, Johanna [Naturvaardsverket, Stockholm (Sweden); Bluhm, Goesta [Karolinska institutet, Miljoemedicin, Stockholm (Sweden); Bolin, Karl [KTH, Kungliga Tekniska Hoegskolan, Stockholm (Sweden)] [and others

    2012-05-15

    The aim of the project Wind power Effects on Human Interests is to describe, analyse and value research on how wind power may affect human interests, and to present: 'what we can say based on what we know today'. The report addresses managers, officials, wind power projectors and also the general public. Research on how wind power may affect health, economy and businesses, and the landscape is analyzed. The process of gaining approval for wind power connected to above mentioned interests is also studied and valued.

  9. On translation equivalence

    Institute of Scientific and Technical Information of China (English)

    石雏凤

    2009-01-01

    Nida's translation theories, especially for his "Dynamic equivalence theory", are highly praised and adopted in Chinese translation circle. Howev-er, there are a lot of criticism and misunderstanding at the same time. This paper explores the issue on translation equivalence so as to benefit our translation studies on both theory and practice level.

  10. Equivalence principles exotica

    Institute of Scientific and Technical Information of China (English)

    C.S. UNNIKRISHNAN; George T. GILLIES

    2008-01-01

    This is a short review of the different prin-ciples of equivalence stated and used in the context of the gravitational interaction. We emphasize the need for precision in stating and differentiating these different equivalence principles, especially in the context of preva-lent confusion regarding the applicability of the weak equivalence principle in quantum mechanics. We discuss several empirical results pertaining to the validity of the equivalence principle in exotic physical sitautions not di-rectly amenable to experimental tests. We conclude with a section on the physical basis of the universal validity of the equivalence principle, as manifest in the universality of free fall, and discuss its link to cosmic gravity.

  11. HRM, POWER and possible spaces of becoming human

    DEFF Research Database (Denmark)

    Bramming, Pia

    2003-01-01

    institutions, the power of aleader or person in terms of the right to execute punishment and the duty to obedienceor empowerment, as a countermove to the effects of bureaucratic workplace routines`... where initiative is stifled and workers become alienated'1. Indirectly one canidentify power as interesting...

  12. Energy Harvesting from Upper-Limb Pulling Motions for Miniaturized Human-Powered Generators

    Directory of Open Access Journals (Sweden)

    Jeongjin Yeo

    2015-07-01

    Full Text Available The human-powered self-generator provides the best solution for individuals who need an instantaneous power supply for travel, outdoor, and emergency use, since it is less dependent on weather conditions and occupies less space than other renewable power supplies. However, many commercial portable self-generators that employ hand-cranking are not used as much as expected in daily lives although they have enough output capacity due to their intensive workload. This study proposes a portable human-powered generator which is designed to obtain mechanical energy from an upper limb pulling motion for improved human motion economy as well as efficient human-mechanical power transfer. A coreless axial-flux permanent magnet machine (APMM and a flywheel magnet rotor were used in conjunction with a one-way clutched power transmission system in order to obtain effective power from the pulling motion. The developed prototype showed an average energy conversion efficiency of 30.98% and an average output power of 0.32 W with a maximum of 1.89 W. Its small form factor (50 mm × 32 mm × 43.5 mm, 0.05 kg and the substantial electricity produced verify the effectiveness of the proposed method in the utilization of human power. It is expected that the developed generator could provide a mobile power supply.

  13. Energy Harvesting from Upper-Limb Pulling Motions for Miniaturized Human-Powered Generators.

    Science.gov (United States)

    Yeo, Jeongjin; Ryu, Mun-ho; Yang, Yoonseok

    2015-07-03

    The human-powered self-generator provides the best solution for individuals who need an instantaneous power supply for travel, outdoor, and emergency use, since it is less dependent on weather conditions and occupies less space than other renewable power supplies. However, many commercial portable self-generators that employ hand-cranking are not used as much as expected in daily lives although they have enough output capacity due to their intensive workload. This study proposes a portable human-powered generator which is designed to obtain mechanical energy from an upper limb pulling motion for improved human motion economy as well as efficient human-mechanical power transfer. A coreless axial-flux permanent magnet machine (APMM) and a flywheel magnet rotor were used in conjunction with a one-way clutched power transmission system in order to obtain effective power from the pulling motion. The developed prototype showed an average energy conversion efficiency of 30.98% and an average output power of 0.32 W with a maximum of 1.89 W. Its small form factor (50 mm × 32 mm × 43.5 mm, 0.05 kg) and the substantial electricity produced verify the effectiveness of the proposed method in the utilization of human power. It is expected that the developed generator could provide a mobile power supply.

  14. Methane and carbon dioxide emission from hydroelectric power plants in the Amazon region compared with the equivalent thermoelectric power plants; Emissoes de metano e dioxido de carbono de hidreletricas na Amazonia comparadas as de termeletricas equivalentes

    Energy Technology Data Exchange (ETDEWEB)

    Pinguelli Rosa, Luiz; Schaeffer, Roberto; Santos, Marco Aurelio dos

    1996-03-01

    This document studies the theoretical and applied aspects related to the emission of gases responsible by the greenhouse effect from the hydroelectric and thermoelectric power plants 48 refs., 3 figs., 12 tabs.

  15. The influence of elastin-like recombinant polymer on the self-renewing potential of a 3D tissue equivalent derived from human lamina propria fibroblasts and oral epithelial cells.

    Science.gov (United States)

    Kinikoglu, Beste; Rodríguez-Cabello, José Carlos; Damour, Odile; Hasirci, Vasif

    2011-09-01

    Three-dimensional epithelial tissue equivalents tend to lose their self-renewing potential progressively during culture as their epithelial cells lose their proliferative capacity with time. Even though the tissue engineered construct can mimic the native tissue well, it rapidly degrades after implantation due to the insufficient number of proliferating cells in the equivalent. In the present study we demonstrate for the first time that the use of an elastin-like recombinant polymer (ELR) engineered to contain the cell adhesion peptide RGD can result in a 3D tissue equivalent with high self-renewing potential, containing as many proliferative cells as the native tissue itself. The 3D tissue equivalent was reconstructed by the coculture of human lamina propria fibroblasts and oral epithelial cells in the nanofibrous ELR-collagen scaffold. Histological, immunohistological and transmission electron microscopic analyses of this oral mucosa equivalent demonstrated the expression of markers characteristic of epithelial proliferation (Ki67) and differentiation (keratin 13), and also the presence of a pluristratified epithelium and an ultrastructurally well-organized basement membrane expressing laminin 332. The synthesis of new extracellular matrix by the fibroblasts was also demonstrated. The scaffold proposed here presents great potential for tissue engineering applications, and also for studies of epithelial proliferation, and epithelial disorders including carcinogenesis.

  16. Topics in orbit equivalence

    CERN Document Server

    Kechris, Alexander S

    2004-01-01

    This volume provides a self-contained introduction to some topics in orbit equivalence theory, a branch of ergodic theory. The first two chapters focus on hyperfiniteness and amenability. Included here are proofs of Dye's theorem that probability measure-preserving, ergodic actions of the integers are orbit equivalent and of the theorem of Connes-Feldman-Weiss identifying amenability and hyperfiniteness for non-singular equivalence relations. The presentation here is often influenced by descriptive set theory, and Borel and generic analogs of various results are discussed. The final chapter is a detailed account of Gaboriau's recent results on the theory of costs for equivalence relations and groups and its applications to proving rigidity theorems for actions of free groups.

  17. Speaking Truth to Power: Women's Rights as Human Rights

    Science.gov (United States)

    Crocco, Margaret Smith

    2007-01-01

    The author considers the treatment of women's rights as human rights in the social studies curriculum. She discusses the role of the United Nations in promoting women's rights since the adoption of the Universal Declaration of Human Rights in 1948. She also reviews the treatment of women's rights within social studies curriculum today through a…

  18. Speaking Truth to Power: Women's Rights as Human Rights

    Science.gov (United States)

    Crocco, Margaret Smith

    2007-01-01

    The author considers the treatment of women's rights as human rights in the social studies curriculum. She discusses the role of the United Nations in promoting women's rights since the adoption of the Universal Declaration of Human Rights in 1948. She also reviews the treatment of women's rights within social studies curriculum today through a…

  19. Human learning: Power laws or multiple characteristic time scales?

    Directory of Open Access Journals (Sweden)

    Gottfried Mayer-Kress

    2006-09-01

    Full Text Available The central proposal of A. Newell and Rosenbloom (1981 was that the power law is the ubiquitous law of learning. This proposition is discussed in the context of the key factors that led to the acceptance of the power law as the function of learning. We then outline the principles of an epigenetic landscape framework for considering the role of the characteristic time scales of learning and an approach to system identification of the processes of performance dynamics. In this view, the change of performance over time is the product of a superposition of characteristic exponential time scales that reflect the influence of different processes. This theoretical approach can reproduce the traditional power law of practice – within the experimental resolution of performance data sets - but we hypothesize that this function may prove to be a special and perhaps idealized case of learning.

  20. Power-law relaxation in human violent conflicts

    Science.gov (United States)

    Picoli, Sergio; Antonio, Fernando J.; Itami, Andreia S.; Mendes, Renio S.

    2017-08-01

    We study relaxation patterns of violent conflicts after bursts of activity. Data were obtained from available catalogs on the conflicts in Iraq, Afghanistan and Northern Ireland. We find several examples in each catalog for which the observed relaxation curves can be well described by an asymptotic power-law decay (the analog of the Omori's law in geophysics). The power-law exponents are robust, nearly independent of the conflict. We also discuss the exogenous or endogenous nature of the shocks. Our results suggest that violent conflicts share with earthquakes and other natural and social phenomena a common feature in the dynamics of aftershocks.

  1. Estimation of requirements of eolic energy equivalent to the electric generation of the Laguna Verde nuclear power plant; Estimacion de requerimientos de energia eolica equivalente a la generacion electrica de la Central Nucleoelectrica de Laguna Verde

    Energy Technology Data Exchange (ETDEWEB)

    Garcia V, M.A.; Hernandez M, I.A. [Facultad de Ingenieria, Division de Ingenieria Electrica, UNAM, 04510 Mexico D.F. (Mexico)]. E-mail: maiki27@yahoo.com; Martin del Campo M, C. [Facultad de Ingenieria, Laboratorio de Analisis en Ingenieria de Reactores Nucleares, UNAM, Paseo Cuauhnahuac 8532, 62550 Jiutepec, Morelos (Mexico)

    2004-07-01

    The advantages are presented that have the nuclear and eolic energy as for their low environmental impact and to the human health. An exercise is presented in the one that is supposed that the electric power generated by the Laguna Verde Nuclear Power plant (CNLV), with capacity of 1365 M W, it should be produced by eolic energy when in the years 2020 and 2025 the units 1 and 2 of the CNLV reach its useful life and be moved away. It is calculated the number of aero generators that would produce the electric power average yearly of the CNLV, that which is equal to install eolic parks with capacity of 2758 M W, without considering that it will also be invested in systems of back generation to produce electricity when the aero generators stops for lack of wind. (Author)

  2. Development of a Power Assist System of a Walking Chair Based on Human Arm Characteristics

    Science.gov (United States)

    Wu, Yunfeng; Nakamura, Hitoshi; Takeda, Yukio; Higuchi, Masaru; Sugimoto, Koichi

    In this paper, design of control system and power combination mechanism of a power assist system of the walking chair was discussed based on kinetostatic characteristics of human arm. The walking chair is a welfare walking machine which is an alternative vehicle of the wheelchair, and expected to be driven by user's cranking operation with assisting actuator. To efficiently utilize user power as much as possible for long locomotion without giving much fatigue to the user while providing comfortable driving feeling to the user, the human arm characteristics were taken into consideration. Kinetostatic characteristics of the human arm were experimentally investigated for its modeling. This model was applied to the design of mechanism and control system of the power assist system of the walking chair, and design parameters were determined for achieving comfortable driving feeling and efficient utilization of user power.

  3. Estimation and harvesting of human heat power for wearable electronic devices

    Science.gov (United States)

    Dziurdzia, P.; Brzozowski, I.; Bratek, P.; Gelmuda, W.; Kos, A.

    2016-01-01

    The paper deals with the issue of self-powered wearable electronic devices that are capable of harvesting free available energy dissipated by the user in the form of human heat. The free energy source is intended to be used as a secondary power source supporting primary battery in a sensor bracelet. The main scope of the article is a presentation of the concept for a measuring setup used to quantitative estimation of heat power sources in different locations over the human body area. The crucial role in the measurements of the human heat plays a thermoelectric module working in the open circuit mode. The results obtained during practical tests are confronted with the requirements of the dedicated thermoelectric generator. A prototype design of a human warmth energy harvester with an ultra-low power DC-DC converter based on the LTC3108 circuit is analysed.

  4. Kilowatt-Class Fission Power Systems for Science and Human Precursor Missions

    Science.gov (United States)

    Mason, Lee S.; Gibson, Marc Andrew; Poston, Dave

    2013-01-01

    Nuclear power provides an enabling capability for NASA missions that might otherwise be constrained by power availability, mission duration, or operational robustness. NASA and the Department of Energy (DOE) are developing fission power technology to serve a wide range of future space uses. Advantages include lower mass, longer life, and greater mission flexibility than competing power system options. Kilowatt-class fission systems, designated "Kilopower," were conceived to address the need for systems to fill the gap above the current 100-W-class radioisotope power systems being developed for science missions and below the typical 100-k We-class reactor power systems being developed for human exploration missions. This paper reviews the current fission technology project and examines some Kilopower concepts that could be used to support future science missions or human precursors.

  5. Building the Leviathan--Voluntary centralisation of punishment power sustains cooperation in humans.

    Science.gov (United States)

    Gross, Jörg; Méder, Zsombor Z; Okamoto-Barth, Sanae; Riedl, Arno

    2016-02-18

    The prevalence of cooperation among humans is puzzling because cooperators can be exploited by free riders. Peer punishment has been suggested as a solution to this puzzle, but cumulating evidence questions its robustness in sustaining cooperation. Amongst others, punishment fails when it is not powerful enough, or when it elicits counter-punishment. Existing research, however, has ignored that the distribution of punishment power can be the result of social interactions. We introduce a novel experiment in which individuals can transfer punishment power to others. We find that while decentralised peer punishment fails to overcome free riding, the voluntary transfer of punishment power enables groups to sustain cooperation. This is achieved by non-punishing cooperators empowering those who are willing to punish in the interest of the group. Our results show how voluntary power centralisation can efficiently sustain cooperation, which could explain why hierarchical power structures are widespread among animals and humans.

  6. Building the Leviathan – Voluntary centralisation of punishment power sustains cooperation in humans

    Science.gov (United States)

    Gross, Jörg; Méder, Zsombor Z.; Okamoto-Barth, Sanae; Riedl, Arno

    2016-01-01

    The prevalence of cooperation among humans is puzzling because cooperators can be exploited by free riders. Peer punishment has been suggested as a solution to this puzzle, but cumulating evidence questions its robustness in sustaining cooperation. Amongst others, punishment fails when it is not powerful enough, or when it elicits counter-punishment. Existing research, however, has ignored that the distribution of punishment power can be the result of social interactions. We introduce a novel experiment in which individuals can transfer punishment power to others. We find that while decentralised peer punishment fails to overcome free riding, the voluntary transfer of punishment power enables groups to sustain cooperation. This is achieved by non-punishing cooperators empowering those who are willing to punish in the interest of the group. Our results show how voluntary power centralisation can efficiently sustain cooperation, which could explain why hierarchical power structures are widespread among animals and humans. PMID:26888519

  7. Measurement of Required Power with Human-Powered Aircraft in Take-off Ground Running

    Science.gov (United States)

    Yoshikawa, Toshiaki; Sakamoto, Shinsuke; Hori, Kotono; Kusumoto, Hiroshi; Yamamoto, Yasushi; Hattori, Takashi; Sata, Kouta

    In this paper, we propose the method for the measurement of required power and the adjustment of optimum gear ratio in take-off ground running. To get the values of required power and speed, we measured torque of the left side and the right side of pedals, RPM of pedals, and speed of the cockpit frame. In order to improve the take-off speed, some drums were applied, and the optimum gear ratio of the front drum to the rear drum was determined.

  8. Critical Review on Power in Organization: Empowerment in Human Resource Development

    Science.gov (United States)

    Jo, Sung Jun; Park, Sunyoung

    2016-01-01

    Purpose: This paper aims to analyze current practices, discuss empowerment from the theoretical perspectives on power in organizations and suggest an empowerment model based on the type of organizational culture and the role of human resource development (HRD). Design/methodology/approach: By reviewing the classic viewpoint of power, Lukes'…

  9. Critical Review on Power in Organization: Empowerment in Human Resource Development

    Science.gov (United States)

    Jo, Sung Jun; Park, Sunyoung

    2016-01-01

    Purpose: This paper aims to analyze current practices, discuss empowerment from the theoretical perspectives on power in organizations and suggest an empowerment model based on the type of organizational culture and the role of human resource development (HRD). Design/methodology/approach: By reviewing the classic viewpoint of power, Lukes'…

  10. Support of protective work of human error in a nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Yoshizawa, Yuriko [Tokyo Electric Power Co., Inc. (Japan)

    1999-12-01

    The nuclear power plant human factor group of the Tokyo Electric Power Co., Ltd. supports various protective work of human error conducted at the nuclear power plant. Its main researching theme are studies on human factor on operation of a nuclear power plant, and on recovery and common basic study on human factor. In addition, on a base of the obtained informations, assistance to protective work of human error conducted at the nuclear power plant as well as development for its actual use was also promoted. Especially, for actions sharing some dangerous informations, various assistances such as a proposal on actual example analytical method to effectively understand a dangerous information not facially but faithfully, construction of a data base to conveniently share such dangerous information, and practice on non-accident business survey for a hint of effective promotion of the protection work, were promoted. Here were introduced on assistance and investigation for effective sharing of the dangerous informations for various actions on protection of human error mainly conducted in nuclear power plant. (G.K.)

  11. The impact of power on humanity: self-dehumanization in powerlessness.

    Directory of Open Access Journals (Sweden)

    Wenqi Yang

    Full Text Available Power gives people the ability to control themselves and their environment, and this control is considered a fundamental human need. We investigated whether experiencing powerlessness induces the experience of self-dehumanization using three methods: priming, role-playing, and cueing. People in a position of low power viewed themselves (Experiments 1-3 as less human relative to people in a position of high power; furthermore, people with low power believed that they were viewed as less human by others as well (Experiments 2-3. In all of the experiments, human nature traits were most negatively affected by powerlessness in self-perception judgments, and uniquely human traits were most negatively affected by powerlessness in meta-perception judgments. Furthermore, the powerless believed they were viewed as less human not only by the powerful people but also the outside observers of the power dynamic. Self-dehumanization also appears to be a consequence of powerlessness rather than an incidental result of a change in mood or a negative self-view. Our findings are an important extension of previous work on the adverse effects of powerlessness and dehumanization.

  12. The impact of power on humanity: self-dehumanization in powerlessness.

    Science.gov (United States)

    Yang, Wenqi; Jin, Shenghua; He, Surina; Fan, Qian; Zhu, Yijie

    2015-01-01

    Power gives people the ability to control themselves and their environment, and this control is considered a fundamental human need. We investigated whether experiencing powerlessness induces the experience of self-dehumanization using three methods: priming, role-playing, and cueing. People in a position of low power viewed themselves (Experiments 1-3) as less human relative to people in a position of high power; furthermore, people with low power believed that they were viewed as less human by others as well (Experiments 2-3). In all of the experiments, human nature traits were most negatively affected by powerlessness in self-perception judgments, and uniquely human traits were most negatively affected by powerlessness in meta-perception judgments. Furthermore, the powerless believed they were viewed as less human not only by the powerful people but also the outside observers of the power dynamic. Self-dehumanization also appears to be a consequence of powerlessness rather than an incidental result of a change in mood or a negative self-view. Our findings are an important extension of previous work on the adverse effects of powerlessness and dehumanization.

  13. System Equivalent for Real Time Digital Simulator

    Science.gov (United States)

    Lin, Xi

    2011-07-01

    The purpose of this research is to develop a method of making system equivalents for the Real Time Digital Simulator (RTDS), which should enhance its capability of simulating large power systems. The proposed equivalent combines a Frequency Dependent Network Equivalent (FDNE) for the high frequency electromagnetic transients and a Transient Stability Analysis (TSA) type simulation block for the electromechanical transients. The frequency dependent characteristic for FDNE is obtained by curve-fitting frequency domain admittance characteristics using the Vector Fitting method. An approach for approximating the frequency dependent characteristic of large power networks from readily available typical power-flow data is also introduced. A new scheme of incorporating TSA solution in RTDS is proposed. This report shows how the TSA algorithm can be adapted to a real time platform. The validity of this method is confirmed with examples, including the study of a multi in-feed HVDC system based network.

  14. Human Reliability Analysis for Digitized Nuclear Power Plants: Case Study on the LingAo II Nuclear Power Plant

    Directory of Open Access Journals (Sweden)

    Yanhua Zou

    2017-03-01

    Full Text Available The main control room (MCR in advanced nuclear power plants (NPPs has changed from analog to digital control system (DCS. Operation and control have become more automated, centralized, and accurate due to the digitalization of NPPs, which has improved the efficiency and security of the system. New issues associated with human reliability inevitably arise due to the adoption of new accident procedures and digitalization of main control rooms in NPPs. The LingAo II NPP is the first digital NPP in China to apply the state-oriented procedure. In order to address issues related to human reliability analysis for DCS and DCS + state-oriented procedure, the Hunan Institute of Technology conducted a research project based on a cooperative agreement with the LingDong Nuclear Power Co. Ltd. This paper is a brief introduction to the project.

  15. Current Conveyor Equivalent Circuits

    Directory of Open Access Journals (Sweden)

    Tejmal S. Rathore

    2012-02-01

    Full Text Available An equivalence between a class of (current conveyor CC II+ and CC II- circuits is established. CC IIequivalent circuit uses one extra element. However, under certain condition, the extra element can be eliminated. As an illustration of the application of this equivalence, minimal first and second order all-pass filters are derived. Incertain cases, it is possible to compensate the effect of the input resistor of CC at port X. At the end, an open problem of realizing an Nth order (N > 2 minimal all-pass filter is stated.

  16. TEPCO's Approach to Power-Engineer Human Resource Development

    Science.gov (United States)

    Sato, Masaki

    We think 'human resources and technology' is developed only by self-training continuously, keeping higher motivation and practicing repeatedly. Moreover it is indispensable for sustainable development of company. Management vision, top-down message with vertical communication, and bottom-up systematic approaches are necessary for sustainable human resource development, sharing the value with coordination, and in addition, OJT and Off-JT method should be used effectively. This paper shows TEPCO's attempts to develop engineers' technical skills as a reference of a in-company continuing professional development.

  17. 基于等效负载阻抗扰动的分布式MPPT方法研究%A distributed maximum power point tracking method based on the equivalent load impedance disturbance

    Institute of Scientific and Technical Information of China (English)

    黄建明; 吴春华; 徐坤; 付立

    2012-01-01

    The operation principle of photovoltaic optimizer system and the essence of maximum power point tracking (MPPT) are introduced. Each PV module adopts MPPT control algorithm in photovoltaic optimizer system, which leads to wrong judgment of the traditional MPPT method due to the load impedance perturbation. Based on the equivalent load impedance perturbation, the distributed maximum power point tracking (DMPPT) is proposed to solve the problem. Considering the disturbance of control variables and load impedance to track MPP, the interaction between individual modules in the photovoltaic optimizer system is avoided. Finally, comparative experiments prove that the DMPPT method based on the equivalent load impedance perturbation proposed in this paper has the advantage of quick response and perturbation resistance to load impedance. Furthermore, the stability of this method is better than conventional MPPT method.%介绍了光伏优化器系统的工作原理及最大功率点跟踪的本质.针对光伏优化器系统中每块光伏组件进行MPPT控制,造成传统MPPT方法由于负载阻抗扰动而引起误判断的问题,提出了一种基于等效负载阻抗扰动的分布式最大功率点跟踪方法.该方法综合考虑控制量扰动和负载阻抗扰动进行MPPT判断,避免光伏优化器系统中各个独立模块之间的相互影响.通过对比实验证明提出的基于等效负载阻抗扰动的最大功率点跟踪方法具有快速的响应能力及抗负载阻抗扰动能力,其稳定性优于传统的MPPT方法.

  18. Human Factors Evaluation of Advanced Electric Power Grid Visualization Tools

    Energy Technology Data Exchange (ETDEWEB)

    Greitzer, Frank L.; Dauenhauer, Peter M.; Wierks, Tamara G.; Podmore, Robin

    2009-04-01

    This report describes initial human factors evaluation of four visualization tools (Graphical Contingency Analysis, Force Directed Graphs, Phasor State Estimator and Mode Meter/ Mode Shapes) developed by PNNL, and proposed test plans that may be implemented to evaluate their utility in scenario-based experiments.

  19. Derivation of main drivers affecting the possibility of human errors during low power and shutdown operation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ar Ryum; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of); Park, Jin Kyun; Kim, Jae Whan [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    In order to estimate the possibility of human error and identify its nature, human reliability analysis (HRA) methods have been implemented. For this, various HRA methods have been developed so far: techniques for human error rate prediction (THERP), cause based decision tree (CBDT), the cognitive reliability and error analysis method (CREAM) and so on. Most HRA methods have been developed with a focus on full power operation of NPPs even though human performance may more largely affect the safety of the system during low power and shutdown (LPSD) operation than it would when the system is in full power operation. In this regard, it is necessary to conduct a research for developing HRA method to be used in LPSD operation. For the first step of the study, main drivers which affect the possibility of human error have been developed. Drivers which are commonly called as performance shaping factors (PSFs) are aspects of the human's individual characteristics, environment, organization, or task that specifically decrements or improves human performance, thus respectively increasing or decreasing the likelihood of human errors. In order to estimate the possibility of human error and identify its nature, human reliability analysis (HRA) methods have been implemented. For this, various HRA methods have been developed so far: techniques for human error rate prediction (THERP), cause based decision tree (CBDT), the cognitive reliability and error analysis method (CREAM) and so on. Most HRA methods have been developed with a focus on full power operation of NPPs even though human performance may more largely affect the safety of the system during low power and shutdown (LPSD) operation than it would when the system is in full power operation. In this regard, it is necessary to conduct a research for developing HRA method to be used in LPSD operation. For the first step of the study, main drivers which affect the possibility of human error have been developed. Drivers

  20. Calculations of stopping powers and inelastic mean free paths for 20 eV-20 keV electrons in 11 types of human tissue.

    Science.gov (United States)

    Tan, Zhenyu; Liu, Wei

    2013-12-01

    Systematic calculations are performed for determining the stopping powers (SP) and inelastic mean free paths (IMFP) for 20 eV-20 keV electrons in 11 types of human tissue. The calculations are based on a dielectric model, including the Born-Ochkur exchange correction. The optical energy loss functions (OELF) are empirically evaluated, because of the lack of available experimental optical data for the 11 tissues under consideration. The evaluated OELFs are examined by the f-sum rule expected from the dielectric response theory, and by calculation of the mean excitation energy. The calculated SPs are compared with those for PMMA (polymethylmethacrylate, a tissue equivalent material) and liquid water. The SP and IMFP data presented here are the results for the 11 human tissues over the energy range of 20 eV-20 keV, and are of importance in radiotherapy planning and for studies of various radiation effects on human tissues.

  1. 77 FR 55832 - Ambient Air Monitoring Reference and Equivalent Methods: Designation of a New Equivalent Method

    Science.gov (United States)

    2012-09-11

    ... AGENCY Ambient Air Monitoring Reference and Equivalent Methods: Designation of a New Equivalent Method... monitoring ambient air quality. SUMMARY: Notice is hereby given that the Environmental Protection Agency (EPA... concentrations of PM 2.5 in the ambient air. FOR FURTHER INFORMATION CONTACT: Robert Vanderpool, Human...

  2. Mass Equivalent Dyads

    NARCIS (Netherlands)

    van der Wijk, V.; Bai, Shaoping; Ceccarelli, Marco

    2015-01-01

    In this paper it is shown how a general 2-DoF dyad can be designed mass equivalent to a general (1-DoF) link element. This is useful in the synthesis of balanced mechanisms, for instance to increase or reduce the number of DoFs of a balanced mechanism maintaining its balance. Also it can be used as

  3. Mass equivalent triads

    NARCIS (Netherlands)

    van der Wijk, V.

    2015-01-01

    In this paper it is shown how a general 3-DoF triad can be designed mass equivalent to a general (1-DoF) link element. This is useful in the synthesis of shaking force balanced and statically balanced mechanisms, for instance to add or remove a number of DoFs of a balanced mechanism maintaining its

  4. Equivalence of Differential System

    Institute of Scientific and Technical Information of China (English)

    Zheng-xin Zhou

    2004-01-01

    Using refiecting function of Mironenko we construct some differential systems which are equivalent to the given differential system.This gives us an opportunity to find out the monodromic matrix of these periodi csystems which are not integrable in finite terms.

  5. The Impacts of Macroergonomics on Environmental Protection and Human Performance in Power Plants

    Directory of Open Access Journals (Sweden)

    A Azadeh, J Nouri, I Mohammad Fam

    2005-01-01

    Full Text Available Human and his performance is a vital factor in protection of asset including environmental properties. The objective of this study was to evaluate the impact of total system design factors (TSD on human performance in a power plant. The TSD factors are defined as design factors, which have impact on overall performance of the power plants in context of total human engineering or macroergonomics. The systems being studied are the control rooms and maintenance departments of a 2000 MW thermal power plant. To achieve the above objective, the TSD factors were addressed and assessed through a detailed questionnaire. The relationships between TSD factors and human performance were then examined through non-parametric correlation analysis (Kramer’s Phi and Kruskal-Wallis test of means. The results of this study show that the macroergonomic factors such as organizational and safety procedures, teamwork, self-organization, job design and information exchange, influence human performance in the power plant. The findings also suggest that the selected macroergonomic factors are correlated to human performance and must be considered, designed and tested concurrently with the engineering factors at the design phase of the system developmental cycle. Consequently, total system’s faults and organizational errors are reduced to an acceptable level and human performance is significantly increased. The main goal in such program is customer's satisfaction (Internal customers. However, more elaboration on the scientific tools for implementation of TDS factors in context of human performance is also under investigation.

  6. Maximum Power Point Tracking in the Photovoltaic Power Generation Based on Dynamic Equivalent Impedance Matching of LCC Resonant Circuit%基于LCC谐振电路阻抗匹配的光伏发电最大功率点跟踪

    Institute of Scientific and Technical Information of China (English)

    桂存兵; 刘洋; 何业军

    2013-01-01

    为实现光伏发电应用中LCC谐振电路的最大功率点跟踪(MPPT),首先,基于傅里叶级数的动态相量法对LCC谐振电路建立了稳态数学模型.然后,基于阻抗匹配的思想,在其数学模型的基础上提出了一种以开关频率为控制变量的MPPT阻抗匹配方法.最后,根据已有文献提供的最大功率点测量矩阵为依据进行了仿真和实验,通过仿真和实验结果验证了这种阻抗匹配方法的正确性.与其它几种经典的MPPT算法比较,验证了以阻抗匹配思想为基础的MPPT方法有明显的优点.%In order to realize the maximum power point tracking (MPPT) of the series-parallel resonant converter ( LCC) with capacitive output filter in the photovoltaic power generation, firstly, based on Fourier series, a steady-state mathematical model of the LCC resonant circuit is established using dynamic phasor. Then, according to the thought of equivalent impedance matching, a MPPT algorithm is obtained based on the mathematical model of LCC converter. Finally, in terms of measurement matrix of the maximum power which has been provided by the existing literatures, this method of equivalent impedance matching is verified by the results of simulation and experiment. Compared with the classic MPPT algorithm, the MPPT algorithm which accords to the thought of equivalent impedance matching has more obvious advantages.

  7. Effect of different power parameters of Er,Cr:YSGG laser on human dentine.

    Science.gov (United States)

    Ekworapoj, Piyanart; Sidhu, Sharanbir K; McCabe, John F

    2007-09-01

    The aim of this work was to determine the optimal power setting of an Er,Cr:YSGG laser for cutting human dentine to produce a surface that remains suitable as a foundation on which to build and bond a dental restoration. The cutting efficiency and resulting microhardness of the dentine were evaluated for various laser power settings, and representative samples were examined by SEM. The microhardness of the dentine was significantly reduced by 30-50% (p power setting used. The mean ablation efficiency increased in proportion to the power setting of the laser. Although the laser power setting did not affect the extent of reduction in microhardness, it did affect the microstructure of human dentine.

  8. Existence of Hierarchies and Human's Pursuit of Top Hierarchy Lead to Power Law

    CERN Document Server

    Yu, Shuiyuan; Liu, Haitao

    2016-01-01

    The power law is ubiquitous in natural and social phenomena, and is considered as a universal relationship between the frequency and its rank for diverse social systems. However, a general model is still lacking to interpret why these seemingly unrelated systems share great similarity. Through a detailed analysis of natural language texts and simulation experiments based on the proposed 'Hierarchical Selection Model', we found that the existence of hierarchies and human's pursuit of top hierarchy lead to the power law. Further, the power law is a statistical and emergent performance of hierarchies, and it is the universality of hierarchies that contributes to the ubiquity of the power law.

  9. 'But not with the greatest of ease' - A feasibility study of a human-powered ACV

    Science.gov (United States)

    Fowler, H. S.

    1985-06-01

    An assessment is made of the propulsion efficiency-related difficulties that are ineluctably encountered in attempts to design human-powered air cushion vehicles (ACVs). After defining an arbitrary human-powered ACV, a terrain representative of the kind that such a vehicle should be able to traverse is selected to evaluate the feasibility of the design within current engineering and human performance capabilities. An ACV capable of 1 hour of sustained operation over a flat, smooth course of approximately 10 km is foreseen.

  10. Explaining the Power-law Distribution of Human Mobility Through Transportation Modality Decomposition

    CERN Document Server

    Zhao, Kai; Hui, Pan; Rao, Weixiong; Tarkoma, Sasu

    2014-01-01

    Human mobility has been empirically observed to exhibit Levy flight characteristics and behaviour with power-law distributed jump size. The fundamental mechanisms behind this behaviour has not yet been fully explained. In this paper, we analyze urban human mobility and we propose to explain the Levy walk behaviour observed in human mobility patterns by decomposing them into different classes according to the different transportation modes, such as Walk/Run, Bicycle, Train/Subway or Car/Taxi/Bus. Our analysis is based on two real-life GPS datasets containing approximately 10 and 20 million GPS samples with transportation mode information. We show that human mobility can be modelled as a mixture of different transportation modes, and that these single movement patterns can be approximated by a lognormal distribution rather than a power-law distribution. Then, we demonstrate that the mixture of the decomposed lognormal flight distributions associated with each modality is a power-law distribution, providing an e...

  11. From equivalence to adaptation

    Directory of Open Access Journals (Sweden)

    Paulina Borowczyk

    2009-01-01

    Full Text Available The aim of this paper is to illustrate in which cases the translators use the adaptation when they are confronted with a term related to sociocultural aspects. We will discuss the notions of equivalence and adaptation and their limits in the translation. Some samples from Arte TV news and from the American film Shrek translated into Polish, German and French will be provided as a support for this article.

  12. Modelling of Human Glottis in VLSI for Low Power Architectures

    CERN Document Server

    Raj, Nikhil

    2010-01-01

    The Glottal Source is an important component of voice as it can be considered as the excitation signal to the voice apparatus. Nowadays, new techniques of speech processing such as speech recognition and speech synthesis use the glottal closure and opening instants. Current models of the glottal waves derive their shape from approximate information rather than from exactly measured data. General method concentrate on assessment of the glottis opening using optical, acoustical methods, or on visualization of the larynx position using ultrasound, computer tomography or magnetic resonance imaging techniques. In this work, circuit model of Human Glottis using MOS is designed by exploiting fluid volume velocity to current, fluid pressure to voltage, and linear and nonlinear mechanical impedances to linear and nonlinear electrical impedances. The glottis modeled as current source includes linear, non-linear impedances to represent laminar and turbulent flow respectively, in vocal tract. The MOS modelling and simula...

  13. Equivalence Relations of -Algebra Extensions

    Indian Academy of Sciences (India)

    Changguo Wei

    2010-04-01

    In this paper, we consider equivalence relations of *-algebra extensions and describe the relationship between the isomorphism equivalence and the unitary equivalence. We also show that a certain group homomorphism is the obstruction for these equivalence relations to be the same.

  14. The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human

    OpenAIRE

    2012-01-01

    Abstract Background As a model organism in biomedicine, the rhesus macaque (Macaca mulatta) is the most widely used nonhuman primate. Although a draft genome sequence was completed in 2007, there has been no systematic genome-wide comparison of genetic variation of this species to humans. Comparative analysis of functional and nonfunctional diversity in this highly abundant and adaptable non-human primate could inform its use as a model for human biology, and could reveal how variation in pop...

  15. Power

    DEFF Research Database (Denmark)

    Elmholdt, Claus Westergård; Fogsgaard, Morten

    2016-01-01

    In this chapter, we will explore the dynamics of power in processes of creativity, and show its paradoxical nature as both a bridge and a barrier to creativity in organisations. Recent social psychological experimental research (Slighte, de Dreu & Nijstad, 2011) on the relation between power...... and creativity suggests that when managers give people the opportunity to gain power and explicate that there is reason to be more creative, people will show a boost in creative behaviour. Moreover, this process works best in unstable power hierarchies, which implies that power is treated as a negotiable...... and floating source for empowering people in the organisation. We will explore and discuss here the potentials, challenges and pitfalls of power in relation to creativity in the life of organisations today. The aim is to demonstrate that power struggles may be utilised as constructive sources of creativity...

  16. ISRU Reactant, Fuel Cell Based Power Plant for Robotic and Human Mobile Exploration Applications

    Science.gov (United States)

    Baird, Russell S.; Sanders, Gerald; Simon, Thomas; McCurdy, Kerri

    2003-01-01

    Three basic power generation system concepts are generally considered for lander, rover, and Extra-Vehicular Activity (EVA) assistant applications for robotic and human Moon and Mars exploration missions. The most common power system considered is the solar array and battery system. While relatively simple and successful, solar array/battery systems have some serious limitations for mobile applications. For typical rover applications, these limitations include relatively low total energy storage capabilities, daylight only operating times (6 to 8 hours on Mars), relatively short operating lives depending on the operating environment, and rover/lander size and surface use constraints. Radioisotope power systems are being reconsidered for long-range science missions. Unfortunately, the high cost, political controversy, and launch difficulties that are associated with nuclear-based power systems suggests that the use of radioisotope powered landers, rovers, and EVA assistants will be limited. The third power system concept now being considered are fuel cell based systems. Fuel cell power systems overcome many of the performance and surface exploration limitations of solar array/battery power systems and the prohibitive cost and other difficulties associated with nuclear power systems for mobile applications. In an effort to better understand the capabilities and limitations of fuel cell power systems for Moon and Mars exploration applications. NASA is investigating the use of In-Situ Resource Utilization (ISRU) produced reactant, fuel cell based power plants to power robotic outpost rovers, science equipment, and future human spacecraft, surface-excursion rovers, and EVA assistant rovers. This paper will briefly compare the capabilities and limitations of fuel cell power systems relative to solar array/battery and nuclear systems, discuss the unique and enhanced missions that fuel cell power systems enable, and discuss the common technology and system attributes

  17. Improving human reliability through better nuclear power plant system design. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Golay, M.W.

    1995-01-10

    The project on {open_quotes}Development of a Theory of the Dependence of Human Reliability upon System Designs as a Means of Improving Nuclear Power Plant Performance{close_quotes} has been undertaken in order to address the important problem of human error in advanced nuclear power plant designs. Most of the creativity in formulating such concepts has focused upon improving the mechanical reliability of safety related plant systems. However, the lack of a mature theory has retarded similar progress in reducing the likely frequencies of human errors. The main design mechanism used to address this class of concerns has been to reduce or eliminate the human role in plant operations and accident response. The plan of work being pursued in this project is to perform a set of experiments involving human subject who are required to operate, diagnose and respond to changes in computer-simulated systems, relevant to those encountered in nuclear power plants. In the tests the systems are made to differ in complexity in a systematic manner. The computer program used to present the problems to be solved also records the response of the operator as it unfolds. Ultimately this computer is also to be used in compiling the results of the project. The work of this project is focused upon nuclear power plant applications. However, the persuasiveness of human errors in using all sorts of electromechanical machines gives it a much greater potential importance. Because of this we are attempting to pursue our work in a fashion permitting broad generalizations.

  18. Procedure for conducting a human-reliability analysis for nuclear power plants. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bell, B.J.; Swain, A.D.

    1983-05-01

    This document describes in detail a procedure to be followed in conducting a human reliability analysis as part of a probabilistic risk assessment when such an analysis is performed according to the methods described in NUREG/CR-1278, Handbook for Human Reliability Analysis with Emphasis on Nuclear Power Plant Applications. An overview of the procedure describing the major elements of a human reliability analysis is presented along with a detailed description of each element and an example of an actual analysis. An appendix consists of some sample human reliability analysis problems for further study.

  19. Design of Photovoltaic Power System for a Precursor Mission for Human Exploration of Mars

    Science.gov (United States)

    Mcnatt, Jeremiah; Landis, Geoffrey; Fincannon, James

    2016-01-01

    This project analyzed the viability of a photovoltaic power source for technology demonstration mission to demonstrate Mars in-situ resource utilization (ISRU) to produce propellant for a future human mission, based on technology available within the next ten years. For this assessment, we performed a power-system design study for a scaled ISRU demonstrator lander on the Mars surface based on existing solar array technologies.

  20. The Impacts of Total System Design Factors on Human Performance in Power Plants

    Directory of Open Access Journals (Sweden)

    A. Azadeh

    2005-01-01

    Full Text Available The objective of this study is to evaluate the impact of total system design factors (TSD on human performance in a power plant. The TSD factors are defined as design factors, which have an impact on the overall performance of the power plants in the context of total human engineering or macroergonomy. The systems being studied are the control rooms and maintenance departments of a 2000 MW thermal power plant? To achieve the above objective the TSD factors were addressed and assessed through a detailed questionnaire. The relationships between TSD factors and human performance were then examined through non-parametric correlation analysis (Kramer’s Phi and Kruskal-Wallis test of means. The selected TSD factors are related to procedures, work assessment, teamwork, self-organization, information exchange and communication. The results of this study show that the TSD factors such as organizational and safety procedures, teamwork, self-organization, job design and information exchange influence human performance in the power plant. The findings also suggest that the selected TSD factors correlate to human performance and must be considered, designed and tested concurrently with the engineering factors at the design phase of the system development cycle. Consequently, total system’s faults and organizational errors are reduced to an acceptable level and human performance is significantly increased. This is a challenging task for designers of power plants but is required if we are facing unforeseen and complex issues of such systems in twenty-first century. The methodology discussed here may be easily extended to all types of power plants.

  1. Comments on TNT Equivalence

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, P.W.

    1994-07-01

    The term ``TNT Equivalence`` is used throughout the explosives and related industries to compare the effects of the output of a given explosive to that of TNT. This is done for technical design reasons in scaling calculation such as for the prediction of blast waves, craters, and structural response, and is also used as a basis for government regulations controlling the shipping, handling and storage of explosive materials, as well as for the siting and design of explosive facilities. TNT equivalence is determined experimentally by several different types of tests, the most common of which include: plate dent, ballistic mortar, trauzl, sand crush, and air blast. All of these tests do not necessarily measure the same output property of the sample explosive. As examples of this, some tests depend simply upon the CJ pressure, some depend upon the PV work in the CJ zone and in the Taylor wave behind the CJ plane, some are functions of the total work which includes that from secondary combustion in the air mixing region of the fireball and are acutely effected by the shape of the pressure-time profile of the wave. Some of the tests incorporate systematic errors which are not readily apparent, and which have a profound effect upon skewing the resultant data. Further, some of the tests produce different TNT Equivalents for the same explosive which are a function of the conditions at which the test is run. This paper describes the various tests used, discusses the results of each test and makes detailed commentary on what the test is actually measuring, how the results may be interpreted, and if and how these results can be predicted by first principals based calculations. Extensive data bases are referred to throughout the paper and used in examples for each point in the commentaries.

  2. Generation of electrical power under human skin by subdermal solar cell arrays for implantable bioelectronic devices.

    Science.gov (United States)

    Song, Kwangsun; Han, Jung Hyun; Yang, Hyung Chae; Nam, Kwang Il; Lee, Jongho

    2017-06-15

    Medical electronic implants can significantly improve people's health and quality of life. These implants are typically powered by batteries, which usually have a finite lifetime and therefore must be replaced periodically using surgical procedures. Recently, subdermal solar cells that can generate electricity by absorbing light transmitted through skin have been proposed as a sustainable electricity source to power medical electronic implants in bodies. However, the results to date have been obtained with animal models. To apply the technology to human beings, electrical performance should be characterized using human skin covering the subdermal solar cells. In this paper, we present electrical performance results (up to 9.05mW/cm(2)) of the implantable solar cell array under 59 human skin samples isolated from 10 cadavers. The results indicate that the power densities depend on the thickness and tone of the human skin, e.g., higher power was generated under thinner and brighter skin. The generated power density is high enough to operate currently available medical electronic implants such as pacemakers that require tens of microwatt.

  3. The double power law in human collaboration behavior: The case of Wikipedia

    Science.gov (United States)

    Kwon, Okyu; Son, Woo-Sik; Jung, Woo-Sung

    2016-11-01

    We study human behavior in terms of the inter-event time distribution of revision behavior on Wikipedia, an online collaborative encyclopedia. We observe a double power law distribution for the inter-editing behavior at the population level and a single power law distribution at the individual level. Although interactions between users are indirect or moderate on Wikipedia, we determine that the synchronized editing behavior among users plays a key role in determining the slope of the tail of the double power law distribution.

  4. Human factors research in Central Research Institute of Electric Power Industry creation of safety culture

    Energy Technology Data Exchange (ETDEWEB)

    Horie, Yasuo [Central Research Inst. of Electric Power Industry, Tokyo (Japan)

    2002-03-01

    To prevent accident of nuclear power plant, Human Factors Center was built in the Central Research Institute of Electric Power Industry in July 1987. It developed an evaluation method of human error cases and an application method of human factors information. Now it continues analysis and application of human factors information, development of training/work support tools and research/experiment of human behavior. Japan-Human Performance Evaluation System (J-HPES) was developed as an analytical system for analysis and evaluation of human factors related to the trouble and for using the result as the common property by storage the analytical results. J-HPES has a standard procedure consisted of collecting and analyzing data and proposing the countermeasures. The analytical results are arranged by 4 kinds of charts by putting into the form of a diagram. Moreover, it tries to find the causes with indirect and potential causes. Two kinds of materials, Caution Report and Human Factors Precept by means of Illustrations, are published. People can gain access to HFC database by URL http://criepi.denken.or.jp/CRIEPI/HFC/DB. To prevent these accidents, creation of human factors culture has been required. Five kinds of teaching materials and the training method are developed. (S.Y.)

  5. Human DNA quantification and sample quality assessment: Developmental validation of the PowerQuant(®) system.

    Science.gov (United States)

    Ewing, Margaret M; Thompson, Jonelle M; McLaren, Robert S; Purpero, Vincent M; Thomas, Kelli J; Dobrowski, Patricia A; DeGroot, Gretchen A; Romsos, Erica L; Storts, Douglas R

    2016-07-01

    Quantification of the total amount of human DNA isolated from a forensic evidence item is crucial for DNA normalization prior to short tandem repeat (STR) DNA analysis and a federal quality assurance standard requirement. Previous commercial quantification methods determine the total human DNA and total human male DNA concentrations, but provide limited information about the condition of the DNA sample. The PowerQuant(®) System includes targets for quantification of total human and total human male DNA as well as targets for evaluating whether the human DNA is degraded and/or PCR inhibitors are present in the sample. A developmental validation of the PowerQuant(®) System was completed, following SWGDAM Validation Guidelines, to evaluate the assay's specificity, sensitivity, precision and accuracy, as well as the ability to detect degraded DNA or PCR inhibitors. In addition to the total human DNA and total human male DNA concentrations in a sample, data from the degradation target and internal PCR control (IPC) provide a forensic DNA analyst meaningful information about the quality of the isolated human DNA and the presence of PCR inhibitors in the sample that can be used to determine the most effective workflow and assist downstream interpretation.

  6. Ultrasonication and the quality of human milk: variation of power and time of exposure.

    Science.gov (United States)

    Christen, Lukas; Lai, Ching Tat; Hartmann, Peter E

    2012-08-01

    Donor human milk is pasteurized to prevent the potential risk of the transmission of pathogens to preterm infants. Currently, Holder pasteurization (human milk held at 62·5°C for 30 min) is used in most human milk banks, but has the disadvantage that it results in excessive inactivation of important bioactive components. Power-ultrasound (20-100 kHz) is an emerging technology for the preservation of foods and could be an alternative method for the treatment of human milk. The aim of this study was to investigate the effect of different ultrasound settings on the elimination of Escherichia coli and the retention of bile salt stimulated lipase (BSSL) activity. Ultrasonication with a constant power decreased Esch. coli viability exponentially over time until the processing temperature increased to sub-pasteurization level to between 51·4 and 58·5°C, then a log10 1·3 decrease was observed (Phuman milk using high ultrasound power over a short exposure time to ensure that the temperature remains below the critical level for protein denaturation. Alternatively, the use of lower power settings such as the 26 W used in the present studies would require a cooling system to ensure the human milk BSSL was protected against temperature denaturation.

  7. A development of the Human Factors Assessment Guide for the Study of Erroneous Human Behaviors in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Yeon Ju; Lee, Yong Hee; Jang, Tong Il; Kim, Sa Kil [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-08-15

    The aim of this paper is to describe a human factors assessment guide for the study of the erroneous characteristic of operators in nuclear power plants (NPPs). We think there are still remaining the human factors issues such as an uneasy emotion, fatigue and stress, varying mental workload situation by digital environment, and various new type of unsafe response to digital interface for better decisions, although introducing an advanced main control room. These human factors issues may not be resolved through the current human reliability assessment which evaluates the total probability of a human error occurring throughout the completion of a specific task. This paper provides an assessment guide for the human factors issues a set of experimental methodology, and presents an assessment case of measurement and analysis especially from neuro physiology approach. It would be the most objective psycho-physiological research technique on human performance for a qualitative analysis considering the safety aspects. This paper can be trial to experimental assessment of erroneous behaviors and their influencing factors, and it can be used as an index for recognition and a method to apply human factors engineering V and V, which is required as a mandatory element of human factor engineering program plan for a NPP design.

  8. Human-Machine interface for off normal and emergency situations in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Kee Choon [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-01-01

    Many nuclear power plants (NPPs) have reported that a high percentage of all major failures in the plants are caused by human errors. Therefore, there has been much focus on elimination of human errors, enhancement of human performance, and general improvement of human machine interface (HMI). Both the utility management and the regulators are demanding improvement in this area. The International Atomic Energy Agency (IAEA) Specialists' Meeting on 'Human-Machine Interface for Off Normal and Emergency Situations in Nuclear Power Plants' was co-organized by the Korea Atomic Energy Research Institute (KAERI) and the Korea Power Engineering Company, INC (KOPEC), and took place in Taejeon, Republic of Korea, 1999 October 26-28. Fifty eight participants, representing nine member countries reviewed recent developments and discussed directions for future efforts in the Human-Machine Interface for Off Normal and Emergency Situations in NPPs. Twenty papers were presented, covering a wide spectrum of technical and scientific subjects including recent experience and benefits from Operational Experience with HMI, Development of HMI System, Licensing Issues for HMI and Future Development and Trends. (Author)

  9. An improvement of the applicability of human factors guidelines for coping with human factors issues in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. H.; Lee, J. Y. [KAERI, Taejon (Korea, Republic of)

    2003-07-01

    Human factors have been well known as one of the key factors to the system effectiveness as well as the efficiency and safety of nuclear power plants(NPPs). Human factors engineering(HFE) are included in periodic safety review(PSR) on the existing NPPs and the formal safety assessment for the new ones. However, HFE for NPPs is still neither popular in practice nor concrete in methodology. Especially, the human factors guidelines, which are the most frequent form of human factors engineering in practice, reveal the limitations in their applications. We discuss the limitations and their casual factors found in human factors guidelines in order to lesson the workload of HFE practitioners and to improve the applicability of human factors guidelines. According to the purposes and the phases of HFE for NPPs, more selective items and specified criteria should be prepared carefully in the human factors guidelines for the each HFE applications in practice. These finding on the human factors guidelines can be transferred to the other HFE application field, such as military, aviation, telecommunication, HCI, and product safety.

  10. Testing the weak equivalence principle

    Science.gov (United States)

    Nobili, Anna M.; Comandi, Gian Luca; Pegna, Raffaello; Bramanti, Donato; Doravari, Suresh; Maccarone, Francesco; Lucchesi, David M.

    2010-01-01

    The discovery of Dark Energy and the fact that only about 5% of the mass of the universe can be explained on the basis of the current laws of physics have led to a serious impasse. Based on past history, physics might indeed be on the verge of major discoveries; but the challenge is enormous. The way to tackle it is twofold. On one side, scientists try to perform large scale direct observations and measurements - mostly from space. On the other, they multiply their efforts to put to the most stringent tests ever the physical theories underlying the current view of the physical world, from the very small to the very large. On the extremely small scale very exciting results are expected from one of the most impressive experiments in the history of mankind: the Large Hadron Collider. On the very large scale, the universe is dominated by gravity and the present impasse undoubtedly calls for more powerful tests of General Relativity - the best theory of gravity to date. Experiments testing the Weak Equivalence Principle, on which General Relativity ultimately lies, have the strongest probing power of them all; a breakthrough in sensitivity is possible with the “Galileo Galilei” (GG) satellite experiment to fly in low Earth orbit.

  11. Developmental changes of BOLD signal correlations with global human EEG power and synchronization during working memory.

    Science.gov (United States)

    Michels, Lars; Lüchinger, Rafael; Koenig, Thomas; Martin, Ernst; Brandeis, Daniel

    2012-01-01

    In humans, theta band (5-7 Hz) power typically increases when performing cognitively demanding working memory (WM) tasks, and simultaneous EEG-fMRI recordings have revealed an inverse relationship between theta power and the BOLD (blood oxygen level dependent) signal in the default mode network during WM. However, synchronization also plays a fundamental role in cognitive processing, and the level of theta and higher frequency band synchronization is modulated during WM. Yet, little is known about the link between BOLD, EEG power, and EEG synchronization during WM, and how these measures develop with human brain maturation or relate to behavioral changes. We examined EEG-BOLD signal correlations from 18 young adults and 15 school-aged children for age-dependent effects during a load-modulated Sternberg WM task. Frontal load (in-)dependent EEG theta power was significantly enhanced in children compared to adults, while adults showed stronger fMRI load effects. Children demonstrated a stronger negative correlation between global theta power and the BOLD signal in the default mode network relative to adults. Therefore, we conclude that theta power mediates the suppression of a task-irrelevant network. We further conclude that children suppress this network even more than adults, probably from an increased level of task-preparedness to compensate for not fully mature cognitive functions, reflected in lower response accuracy and increased reaction time. In contrast to power, correlations between instantaneous theta global field synchronization and the BOLD signal were exclusively positive in both age groups but only significant in adults in the frontal-parietal and posterior cingulate cortices. Furthermore, theta synchronization was weaker in children and was--in contrast to EEG power--positively correlated with response accuracy in both age groups. In summary we conclude that theta EEG-BOLD signal correlations differ between spectral power and synchronization and that

  12. Developmental changes of BOLD signal correlations with global human EEG power and synchronization during working memory.

    Directory of Open Access Journals (Sweden)

    Lars Michels

    Full Text Available In humans, theta band (5-7 Hz power typically increases when performing cognitively demanding working memory (WM tasks, and simultaneous EEG-fMRI recordings have revealed an inverse relationship between theta power and the BOLD (blood oxygen level dependent signal in the default mode network during WM. However, synchronization also plays a fundamental role in cognitive processing, and the level of theta and higher frequency band synchronization is modulated during WM. Yet, little is known about the link between BOLD, EEG power, and EEG synchronization during WM, and how these measures develop with human brain maturation or relate to behavioral changes. We examined EEG-BOLD signal correlations from 18 young adults and 15 school-aged children for age-dependent effects during a load-modulated Sternberg WM task. Frontal load (in-dependent EEG theta power was significantly enhanced in children compared to adults, while adults showed stronger fMRI load effects. Children demonstrated a stronger negative correlation between global theta power and the BOLD signal in the default mode network relative to adults. Therefore, we conclude that theta power mediates the suppression of a task-irrelevant network. We further conclude that children suppress this network even more than adults, probably from an increased level of task-preparedness to compensate for not fully mature cognitive functions, reflected in lower response accuracy and increased reaction time. In contrast to power, correlations between instantaneous theta global field synchronization and the BOLD signal were exclusively positive in both age groups but only significant in adults in the frontal-parietal and posterior cingulate cortices. Furthermore, theta synchronization was weaker in children and was--in contrast to EEG power--positively correlated with response accuracy in both age groups. In summary we conclude that theta EEG-BOLD signal correlations differ between spectral power and

  13. Potential Applications for Radioisotope Power Systems in Support of Human Exploration Missions

    Science.gov (United States)

    Cataldo, Robert L.; Colozza, Anthony J.; Schmitz, Paul C.

    2013-01-01

    Radioisotope power systems (RPS) for space applications have powered over 27 U.S. space systems, starting with Transit 4A and 4B in 1961, and more recently with the successful landing of the Mars Science Laboratory rover Curiosity in August 2012. RPS enable missions with destinations far from the Sun with faint solar flux, on planetary surfaces with dense or dusty atmospheres, and at places with long eclipse periods where solar array sizes and energy storage mass become impractical. RPS could also provide an enabling capability in support of human exploration activities. It is envisioned that with the higher power needs of most human mission concepts, a high efficiency thermal-to-electric technology would be required such as the Advanced Stirling Radioisotope generator (ASRG). The ASRG should be capable of a four-fold improvement in efficiency over traditional thermoelectric RPS. While it may be impractical to use RPS as a main power source, many other applications could be considered, such as crewed pressurized rovers, in-situ resource production of propellants, back-up habitat power, drilling, any mobile or remote activity from the main base habitat, etc. This paper will identify potential applications and provide concepts that could be a practical extension of the current ASRG design in providing for robust and flexible use of RPS on human exploration missions.

  14. Establishing Substantial Equivalence: Proteomics

    Science.gov (United States)

    Lovegrove, Alison; Salt, Louise; Shewry, Peter R.

    Wheat is a major crop in world agriculture and is consumed after processing into a range of food products. It is therefore of great importance to determine the consequences (intended and unintended) of transgenesis in wheat and whether genetically modified lines are substantially equivalent to those produced by conventional plant breeding. Proteomic analysis is one of several approaches which can be used to address these questions. Two-dimensional PAGE (2D PAGE) remains the most widely available method for proteomic analysis, but is notoriously difficult to reproduce between laboratories. We therefore describe methods which have been developed as standard operating procedures in our laboratory to ensure the reproducibility of proteomic analyses of wheat using 2D PAGE analysis of grain proteins.

  15. Power Generation from Human Leukocytes/Lymphocytes in Mammalian Biofuel Cell

    Directory of Open Access Journals (Sweden)

    Güray Güven

    2013-01-01

    Full Text Available Alternative to batteries power sources is needed for the human implants of the future that tend to be less invasive and more integrated to human biology and physiology. Human metabolism could be exploited for the generation of power, but mammalian cells protect their energy production apparatus from external electrochemical scavengers. We report here evidence that, in the case of white blood cells, chemical energy can be harvested directly on an electrode as electricity in fuel cells whose stability is roughly parallel to the viability of cells in vitro. Electrochemical activity of human leukocytes immobilized on modified carbon mesh electrodes was investigated by cyclic voltammetry. Oxidation peaks at 0.33 V versus Ag/AgCl were observed. An open-circuit potential of 0.44 V was recorded between anode and cathode compartments where the biofuel cell potential operating under an external load of 5 kΩ was below 0.35 V. Average power outputs of 10 μW (2.4×10-6 μW/cell were increased to 15 μW by the activation of white blood cells. Power densities of 1.5 μW cm−2 for lower than physiological cell concentrations are low for most of today’s implants, but possibility of cell immobilization allows a positive outlook for the future utility of the reported findings.

  16. Bicycle Design: A different approach to improving on the world human powered speed records

    NARCIS (Netherlands)

    Epema, H.K.; Van den Brand, S.; Gregoor, W.; Kooijman, J.D.G.; Pereboom, H.P.; Wielemaker, D.C.; Van der Zweep, C.J.

    2012-01-01

    The current International Human Powered Vehicle Association world records for faired bicycles stand at 133.284km/h for the 200m flying start speed record and 91.562 km for the hour record. Traditionally the recumbent bicycles that have been developed for breaking one of either of these records have

  17. The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection

    Science.gov (United States)

    Hermsen, Cornelus C.; Sauerwein, Robert W.; de Vlas, Sake J.

    2017-01-01

    Controlled human malaria infection (CHMI) in healthy human volunteers is an important and powerful tool in clinical malaria vaccine development. However, power calculations are essential to obtain meaningful estimates of protective efficacy, while minimizing the risk of adverse events. To optimize power calculations for CHMI-based malaria vaccine trials, we developed a novel non-linear statistical model for parasite kinetics as measured by qPCR, using data from mosquito-based CHMI experiments in 57 individuals. We robustly account for important sources of variation between and within individuals using a Bayesian framework. Study power is most dependent on the number of individuals in each treatment arm; inter-individual variation in vaccine efficacy and the number of blood samples taken per day matter relatively little. Due to high inter-individual variation in the number of first-generation parasites, hepatic vaccine trials required significantly more study subjects than erythrocytic vaccine trials. We provide power calculations for hypothetical malaria vaccine trials of various designs and conclude that so far, power calculations have been overly optimistic. We further illustrate how upcoming techniques like needle-injected CHMI may reduce required sample sizes. PMID:28081133

  18. Power Harvesting from Human Serum in Buckypaper-Based Enzymatic Biofuel Cell

    Directory of Open Access Journals (Sweden)

    Güray eGüven

    2016-02-01

    Full Text Available The requirement for a miniature, high density, long life, rechargeable power source is common to a vast majority of microsystems, including the implantable devices for medical applications. A model biofuel cell system operating in human serum has been studied for future applications of biomedical and implantable medical devices. Anodic and cathodic electrodes were made of carbon nanotube –buckypaper modified with PQQ-dependent glucose dehydrogenase and laccase, respectively. Modified electrodes were characterized electrochemically and assembled in a biofuel cell set-up. Power density of 16.12 μW/cm2 was achieved in human serum for lower than physiological glucose concentrations. Increasing the glucose concentration and biofuel cell temperature caused an increase on power output leading up to 49.16 μW/cm2.

  19. Power generation from human body motion through magnet and coil arrays with magnetic spring

    Science.gov (United States)

    Zhang, Qian; Wang, Yufeng; Kim, Eun Sok

    2014-02-01

    This article presents a hand-held electromagnetic energy harvester which can be used to harvest tens of mW power level from human body motion. A magnet array, aligned to a coil array for maximum magnetic flux change, is suspended by a magnetic spring for a resonant frequency of several Hz and is stabilized horizontally by graphite sheets for reducing the friction. An analytical model of vibration-driven energy harvester with magnetic spring through magnet and coil arrays is developed to explore the power generation from vibrations at low frequency and large amplitude. When the energy harvester (occupying 120 cc and weighing 180 g) is placed in a backpack of a human walking at various speeds, the power output increases as the walking speed increases from 0.45 m/s (slow walking) to 3.58 m/s (slow running), and reaches 32 mW at 3.58 m/s.

  20. Optimization of a Human-Powered Aircraft Using Fluid–Structure Interaction Simulations

    Directory of Open Access Journals (Sweden)

    Bob Vanderhoydonck

    2016-08-01

    Full Text Available The special type of aircrafts in which the human power of the pilot is sufficient to take off and sustain flight are known as Human-Powered Aircrafts (HPAs. To explore the peculiarities of these aircrafts, the aerodynamic performance of an existing design is evaluated first, using both the vortex lattice method and computational fluid dynamics. In a second step, it is attempted to design and optimize a new HPA capable of winning the Kremer International Marathon Competition. The design will be special in that it allows one to include a second pilot on board the aircraft. As the structural deflection of the wing is found to be a key aspect during design, fluid–structure interaction simulations are performed and included in the optimization procedure. To assess the feasibility of winning the competition, the physical performance of candidate pilots is measured and compared with the predicted required power.

  1. Recommendations to the NRC on human engineering guidelines for nuclear power plant maintainability

    Energy Technology Data Exchange (ETDEWEB)

    Badalamente, R.V.; Fecht, B.A.; Blahnik, D.E.; Eklund, J.D.; Hartley, C.S.

    1986-03-01

    This document contains human engineering guidelines which can enhance the maintainability of nuclear power plants. The guidelines have been derived from general human engineering design principles, criteria, and data. The guidelines may be applied to existing plants as well as to plants under construction. They apply to nuclear power plant systems, equipment and facilities, as well as to maintenance tools and equipment. The guidelines are grouped into seven categories: accessibility and workspace, physical environment, loads and forces, maintenance facilities, maintenance tools and equipment, operating equipment design, and information needs. Each chapter of the document details specific maintainability problems encountered at nuclear power plants, the safety impact of these problems, and the specific maintainability design guidelines whose application can serve to avoid these problems in new or existing plants.

  2. Stuttering Equivalence for Parity Games

    CERN Document Server

    Cranen, Sjoerd; Willemse, Tim A C

    2011-01-01

    We study the process theoretic notion of stuttering equivalence in the setting of parity games. We demonstrate that stuttering equivalent vertices have the same winner in the parity game. This means that solving a parity game can be accelerated by minimising the game graph with respect to stuttering equivalence. While, at the outset, it might not be clear that this strategy should pay off, our experiments using typical verification problems illustrate that stuttering equivalence speeds up solving parity games in many cases.

  3. A Human Reliability Analysis of Post- Accident Human Errors in the Low Power and Shutdown PSA of KSNP

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Daeil; Kim, J. H.; Jang, S. C

    2007-03-15

    Korea Atomic Energy Research Institute, using the ANS low power and shutdown (LPSD) probabilistic risk assessment (PRA) Standard, evaluated the LPSD PSA model of the KSNP, Yonggwang Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the post-accident human errors in the LPSD PSA model for the KSNP showed that 10 items among 19 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for post-accident human errors in the LPSD PSA model for the KSNP. Following tasks are the improvements in the HRA of post-accident human errors of the LPSD PSA model for the KSNP compared with the previous one: Interviews with operators in the interpretation of the procedure, modeling of operator actions, and the quantification results of human errors, site visit. Applications of limiting value to the combined post-accident human errors. Documentation of information of all the input and bases for the detailed quantifications and the dependency analysis using the quantification sheets The assessment results for the new HRA results of post-accident human errors using the ANS LPSD PRA Standard show that above 80% items of its supporting requirements for post-accident human errors were graded as its Category II. The number of the re-estimated human errors using the LPSD Korea Standard HRA method is 385. Among them, the number of individual post-accident human errors is 253. The number of dependent post-accident human errors is 135. The quantification results of the LPSD PSA model for the KSNP with new HEPs show that core damage frequency (CDF) is increased by 5.1% compared with the previous baseline CDF It is expected that this study results will be greatly helpful to improve the PSA quality for the domestic nuclear power plants because they have sufficient PSA quality to meet the Category II of Supporting Requirements for the post

  4. Handbook of human-reliability analysis with emphasis on nuclear power plant applications. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Swain, A D; Guttmann, H E

    1983-08-01

    The primary purpose of the Handbook is to present methods, models, and estimated human error probabilities (HEPs) to enable qualified analysts to make quantitative or qualitative assessments of occurrences of human errors in nuclear power plants (NPPs) that affect the availability or operational reliability of engineered safety features and components. The Handbook is intended to provide much of the modeling and information necessary for the performance of human reliability analysis (HRA) as a part of probabilistic risk assessment (PRA) of NPPs. Although not a design guide, a second purpose of the Handbook is to enable the user to recognize error-likely equipment design, plant policies and practices, written procedures, and other human factors problems so that improvements can be considered. The Handbook provides the methodology to identify and quantify the potential for human error in NPP tasks.

  5. The Relationship between Human Operators' Psycho-physiological Condition and Human Errors in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Arryum; Jang, Inseok; Kang, Hyungook; Seong, Poonghyun [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2013-05-15

    The safe operation of nuclear power plants (NPPs) is substantially dependent on the performance of the human operators who operate the systems. In this environment, human errors caused by inappropriate performance of operator have been considered to be critical since it may lead serious problems in the safety-critical plants. In order to provide meaningful insights to prevent human errors and enhance the human performance, operators' physiological conditions such as stress and workload have been investigated. Physiological measurements were considered as reliable tools to assess the stress and workload. T. Q. Tran et al. and J. B. Brooking et al pointed out that operators' workload can be assessed using eye tracking, galvanic skin response, electroencephalograms (EEGs), heart rate, respiration and other measurements. The purpose of this study is to investigate the effect of the human operators' tense level and knowledge level to the number of human errors. For this study, the experiments were conducted in the mimic of the main control rooms (MCR) in NPP. It utilized the compact nuclear simulator (CNS) which is modeled based on the three loop Pressurized Water Reactor, 993MWe, Kori unit 3 and 4 in Korea and the subjects were asked to follow the tasks described in the emergency operating procedures (EOP). During the simulation, three kinds of physiological measurement were utilized; Electrocardiogram (ECG), EEG and nose temperature. Also, subjects were divided into three groups based on their knowledge of the plant operation. The result shows that subjects who are tense make fewer errors. In addition, subjects who are in higher knowledge level tend to be tense and make fewer errors. For the ECG data, subjects who make fewer human errors tend to be located in higher tense level area of high SNS activity and low PSNS activity. The results of EEG data are also similar to ECG result. Beta power ratio of subjects who make fewer errors was higher. Since beta

  6. Transforming from Economic Power to Soft Power: Challenges for Managing Education for Migrant Workers' Children and Human Capital in Chinese Cities

    Science.gov (United States)

    Mok, Ka Ho; Wong, Yu Cheung; Guo, Yu

    2011-01-01

    In July 2010, the State Council of the People's Republic of China published an "Outline for National Educational Development" with a strong conviction to transform China from an economic power into a country of "soft power" and "strength in human resources". In order to realize such a policy goal, the Chinese…

  7. Equivalent Representation Form of Oscillators with Elastic and Damping Nonlinear Terms

    Directory of Open Access Journals (Sweden)

    Alex Elías-Zúñiga

    2013-01-01

    Full Text Available In this work we consider the nonlinear equivalent representation form of oscillators that exhibit nonlinearities in both the elastic and the damping terms. The nonlinear damping effects are considered to be described by fractional power velocity terms which provide better predictions of the dissipative effects observed in some physical systems. It is shown that their effects on the system dynamics response are equivalent to a shift in the coefficient of the linear damping term of a Duffing oscillator. Then, its numerical integration predictions, based on its equivalent representation form given by the well-known forced, damped Duffing equation, are compared to the numerical integration values of its original equations of motion. The applicability of the proposed procedure is evaluated by studying the dynamics response of four nonlinear oscillators that arise in some engineering applications such as nanoresonators, microresonators, human wrist movements, structural engineering design, and chain dynamics of polymeric materials at high extensibility, among others.

  8. Hydration and transparency of the rabbit cornea irradiated with UVB-doses of 0.25 J/cm(2) and 0.5 J/cm(2) compared with equivalent UVB radiation exposure reaching the human cornea from sunlight.

    Science.gov (United States)

    Cejka, Cestmír; Ardan, Taras; Sirc, Jakub; Michálek, Jiří; Beneš, Jiří; Brůnová, Blanka; Rosina, Jozef

    2011-07-01

    Exposure of the cornea to UV radiation from sunlight evokes intraocular inflammation, photokeratitis. Photokeratitis is caused by UVB radiation. It is accompanied by changes of corneal hydration and light absorption. The aim of this study was to examine the effect of two UVB doses on corneal optics in rabbits and to compare these UVB doses with the equivalent exposure of UVB radiation reaching the human cornea from sunlight. Rabbit corneas were irradiated with a daily UVB dose of 0.25 J/cm(2) or 0.5 J/cm(2) for 4 days. One day after finishing the irradiations the rabbits were sacrificed and corneal light absorption measured using our spectrophotometrical method. Corneal hydration was examined using an ultrasonic Pachymeter every experimental day before the irradiation procedure and the last day before sacrificing the animals. Changes in corneal optics appeared after the repeated exposure of the cornea to a UVB dose of 0.25 J/ cm(2) and massively increased after the repeated exposure of the cornea to a UVB dose of 0.5 J/cm(2). The first significant changes in corneal hydration appeared after a single exposure of the cornea to a UVB dose of 0.25 J/cm(2). Changes in corneal hydration appeared after the exposure of the rabbit cornea to a single UVB dose equivalent to 2.6 hours of solar UVB radiation reaching the human cornea, as measured by UVB sensors embedded in the eyes of mannequin heads facing the sun on a beach at noon in July. Repeated exposure of the rabbit cornea to the same UVB dose evoked profound changes in corneal optics. Although comparison of experimental and outdoor conditions are only approximate, the results in rabbits point to the danger for the human eye from UVB radiation when short stays in sunlight are repeated for several consecutive days without UV protection.

  9. Design and experiments of a self-charged power bank by harvesting sustainable human motion

    Directory of Open Access Journals (Sweden)

    Longhan Xie

    2016-05-01

    Full Text Available In this study, a self-charged power bank integrated with an energy harvester was developed to harness human biomechanical energy and sustainably recharge a power bank. In the energy harvester, a spring–mass damping system is used to transform the human body’s movement during walking into the rotation of a gear train and drive rotary generators to produce electricity to recharge the battery through a rectifying circuit. A mathematical model was built to examine the power output of the energy harvester under different excitation conditions. A prototype was built to test the performances of the harvester, and experiments on the prototype fixed on the ankle, wrist, and torso were conducted, which indicated that the measured power output was 0.35 W, 0.16 W, and 10 mW, respectively, when testers walked at 2.0 m/s (the circular frequency of foot step is about 14.5 rad/s. The experiments indicate that a higher walking velocity as well as excitation amplitude and frequency could result in higher output power.

  10. Human power-based energy harvesting strategies for mobile electronic devices

    Institute of Scientific and Technical Information of China (English)

    Dewei JIA; Jing LIU

    2009-01-01

    Energy problems arise with the proliferation of mobile electronic devices, which range from entertainment tools to life saving medical instruments. The large amount of energy consumption and increasing mobility of electronic devices make it urgent that new power sources should be developed. It has been gradually recognized that the human body is highly flexible in generating applicable power from sources of heat dissipation, joint rotation, enforcement of body weight, vertical displacement of mass centers, and even elastic deformation of tissues and other attachments. These basic combinations of daily activities or metabolic phenomena open up possibilities for harvest-ing energy which is strong enough to power mobile or even implantable medical devices which could be used for a long time or be recharged permanently. A comprehensive review is presented in this paper on the latest developed or incubating electricity generation methods based on human power which would serve as promising candidates for future mobile power. Thermal and mechanical energy, investigated more thoroughly so far, will particularly be emphasized. Thermal energy relies on body heat and employs the property of thermoelectric materials, while mechanical energy is generally extracted in the form of enforcement or displacement excitation. For illustration purposes, the piezoelectric effect, dielectric elastomer and the electromagnetic induction couple, which can convert force directly into electricity, were also evaluated. Mean-while, examples are given to explain how to adopt inertia generators for converting displacement energy via piezo-electric, electrostatic, electromagnetic or magnetostrictive vibrators. Finally, future prospects in harvesting energy from human power are made in conclusion.

  11. Personalized keystroke dynamics for self-powered human--machine interfacing.

    Science.gov (United States)

    Chen, Jun; Zhu, Guang; Yang, Jin; Jing, Qingshen; Bai, Peng; Yang, Weiqing; Qi, Xuewei; Su, Yuanjie; Wang, Zhong Lin

    2015-01-27

    The computer keyboard is one of the most common, reliable, accessible, and effective tools used for human--machine interfacing and information exchange. Although keyboards have been used for hundreds of years for advancing human civilization, studying human behavior by keystroke dynamics using smart keyboards remains a great challenge. Here we report a self-powered, non-mechanical-punching keyboard enabled by contact electrification between human fingers and keys, which converts mechanical stimuli applied to the keyboard into local electronic signals without applying an external power. The intelligent keyboard (IKB) can not only sensitively trigger a wireless alarm system once gentle finger tapping occurs but also trace and record typed content by detecting both the dynamic time intervals between and during the inputting of letters and the force used for each typing action. Such features hold promise for its use as a smart security system that can realize detection, alert, recording, and identification. Moreover, the IKB is able to identify personal characteristics from different individuals, assisted by the behavioral biometric of keystroke dynamics. Furthermore, the IKB can effectively harness typing motions for electricity to charge commercial electronics at arbitrary typing speeds greater than 100 characters per min. Given the above features, the IKB can be potentially applied not only to self-powered electronics but also to artificial intelligence, cyber security, and computer or network access control.

  12. A Human Reliability Analysis of Pre-Accident Human Errors in the Low Power and Shutdown PSA of the KSNP

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Daeil; Jang, Seungchul

    2007-03-15

    Korea Atomic Energy Research Institute, using the ANS Low Power /Shutdown (LPSD)PRA Standard, evaluated the LPSD PSA model of the KSNP, Younggwang (YGN) Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the pre-accident human errors in the LPSD PSA model of the KSNP showed that 13 items among 15 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for pre-accident human errors in the LPSD PSA model for the KSNP to improve its quality. We considered potential pre-accident human errors for all manual valves and control/instrumentation equipment of the systems modeled in the KSNP LPSD PSA model except reactor protection system/ engineering safety features actuation system. We reviewed 160 manual valves and 56 control/instrumentation equipment. The number of newly identified pre-accident human errors is 101. Among them, the number of those related to testing/maintenance tasks is 56. The number of those related to calibration tasks is 45. The number of those related to only shutdown operation is 10. It was shown that the pre-accident human errors related to only shutdown operation contributions to the core damage frequency of LPSD PSA model for the KSNP was negligible.The self-assessment results for the new HRA results of pre-accident human errors using the ANS LPSD PRA Standard show that above 80% items of its supporting requirements for post-accident human errors were graded as its Category II or III. It is expected that the HRA results for the pre-accident human errors presented in this study will be greatly helpful to improve the PSA quality for the domestic nuclear power plants because they have sufficient PSA quality to meet the Category II of supporting requirements for the postaccident human errors in the ANS LPSD PRA Standard.

  13. A Human Reliability Analysis of Pre-Accident Human Errors in the Low Power and Shutdown PSA of the KSNP

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Daeil; Jang, Seungchul

    2007-03-15

    Korea Atomic Energy Research Institute, using the ANS Low Power /Shutdown (LPSD)PRA Standard, evaluated the LPSD PSA model of the KSNP, Younggwang (YGN) Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the pre-accident human errors in the LPSD PSA model of the KSNP showed that 13 items among 15 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for pre-accident human errors in the LPSD PSA model for the KSNP to improve its quality. We considered potential pre-accident human errors for all manual valves and control/instrumentation equipment of the systems modeled in the KSNP LPSD PSA model except reactor protection system/ engineering safety features actuation system. We reviewed 160 manual valves and 56 control/instrumentation equipment. The number of newly identified pre-accident human errors is 101. Among them, the number of those related to testing/maintenance tasks is 56. The number of those related to calibration tasks is 45. The number of those related to only shutdown operation is 10. It was shown that the pre-accident human errors related to only shutdown operation contributions to the core damage frequency of LPSD PSA model for the KSNP was negligible.The self-assessment results for the new HRA results of pre-accident human errors using the ANS LPSD PRA Standard show that above 80% items of its supporting requirements for post-accident human errors were graded as its Category II or III. It is expected that the HRA results for the pre-accident human errors presented in this study will be greatly helpful to improve the PSA quality for the domestic nuclear power plants because they have sufficient PSA quality to meet the Category II of supporting requirements for the postaccident human errors in the ANS LPSD PRA Standard.

  14. Highly purified human-derived follicle-stimulating hormone (Bravelle® has equivalent efficacy to follitropin-beta (Follistim ® in infertile women undergoing in vitro fertilization

    Directory of Open Access Journals (Sweden)

    Webster Bobby W

    2003-10-01

    Full Text Available Abstract Background These data compare the efficacy and safety of highly purified human-derived follicle-stimulating hormone (Bravelle(R and recombinant follitropin-β (Follistim(R in women undergoing in vitro fertilization. Methods This report describes the pooled data from two, nearly identical, randomized, controlled, parallel-group, multicenter studies conducted in a total of 19 academic and private IVF-ET centers in the United States. Infertile premenopausal women underwent pituitary down-regulation using leuprolide acetate followed by a maximum of 12 days of subcutaneous Bravelle(R (n = 120 or Follistim(R (n = 118, followed by administration of human chorionic gonadotropin, oocyte retrieval and embryo transfer. The primary efficacy measure was the mean number of oocytes retrieved; secondary efficacy measures included the total dose and duration of gonadotropin treatment; peak serum estradion levels; embryo transfer and implantation rates; chemical, clinical and continuing pregnancies; and live birth rates. All adverse events were recorded and injection site pain was recorded daily using a patient, self-assessment diary. Results Similar efficacy responses were observed for all outcome parameters in the two treatment groups. Although patients receiving Bravelle(R consistently reported a greater number of chemical, clinical and continuing pregnancies, as well as an increased rate of live birth, the data did not attain statistical significance (P > 0.05. The overall incidence of adverse events was similar in both groups, but compared to Follistim(R, injections of Bravelle(R were reported by patients to be significantly less painful (P Conclusions Bravelle(R and Follistim(R had comparable efficacy in controlled ovarian hyperstimulation in women undergoing IVF-ET. There were no differences in the nature or number of adverse events between the treatment groups although Bravelle(R injections were reported to be significantly less painful.

  15. Triboelectric Nanogenerator Enabled Body Sensor Network for Self-Powered Human Heart-Rate Monitoring.

    Science.gov (United States)

    Lin, Zhiming; Chen, Jun; Li, Xiaoshi; Zhou, Zhihao; Meng, Keyu; Wei, Wei; Yang, Jin; Wang, Zhong Lin

    2017-09-26

    Heart-rate monitoring plays a critical role in personal healthcare management. A low-cost, noninvasive, and user-friendly heart-rate monitoring system is highly desirable. Here, a self-powered wireless body sensor network (BSN) system is developed for heart-rate monitoring via integration of a downy-structure-based triboelectric nanogenerator (D-TENG), a power management circuit, a heart-rate sensor, a signal processing unit, and Bluetooth module for wireless data transmission. By converting the inertia energy of human walking into electric power, a maximum power of 2.28 mW with total conversion efficiency of 57.9% was delivered at low operation frequency, which is capable of immediately and sustainably driving the highly integrated BSN system. The acquired heart-rate signal by the sensor would be processed in the signal process circuit, sent to an external device via the Bluetooth module, and displayed on a personal cell phone in a real-time manner. Moreover, by combining a TENG-based generator and a TENG-based sensor, an all-TENG-based wireless BSN system was developed, realizing continuous and self-powered heart-rate monitoring. This work presents a potential method for personal heart-rate monitoring, featured as being self-powered, cost-effective, noninvasive, and user-friendly.

  16. Why scalar-tensor equivalent theories are not physically equivalent?

    CERN Document Server

    Sk., Nayem

    2016-01-01

    Whether Jordan's and Einstein's frame descriptions of F(R) theory of gravity are physically equivalent, is a long standing debate. However, none questioned on true mathematical equivalence, since classical field equations may be translated from one frame to the other following a transformation relation. Nevertheless, true mathematical equivalence is only established, if all the mathematical results derived from one frame may be translated to the other. Here we show that, neither Noether equations, nor quantum equations may be translated from one frame to the other. The reason being the momenta can't be translated. This appears to be the cause for dynamical in-equivalence.

  17. Review of Methods Related to Assessing Human Performance in Nuclear Power Plant Control Room Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Katya L Le Blanc; Ronald L Boring; David I Gertman

    2001-11-01

    With the increased use of digital systems in Nuclear Power Plant (NPP) control rooms comes a need to thoroughly understand the human performance issues associated with digital systems. A common way to evaluate human performance is to test operators and crews in NPP control room simulators. However, it is often challenging to characterize human performance in meaningful ways when measuring performance in NPP control room simulations. A review of the literature in NPP simulator studies reveals a variety of ways to measure human performance in NPP control room simulations including direct observation, automated computer logging, recordings from physiological equipment, self-report techniques, protocol analysis and structured debriefs, and application of model-based evaluation. These methods and the particular measures used are summarized and evaluated.

  18. Cyclic and Inductive Calculi are equivalent

    CERN Document Server

    Voicu, Razvan

    2011-01-01

    Brotherston and Simpson [citation] have formalized and investigated cyclic reasoning, reaching the important conclusion that it is at least as powerful as inductive reasoning (specifically, they showed that each inductive proof can be translated into a cyclic proof). We add to their investigation by proving the converse of this result, namely that each inductive proof can be translated into an inductive one. This, in effect, establishes the equivalence between first order cyclic and inductive calculi.

  19. Cyclic and Inductive Calculi are equivalent

    OpenAIRE

    Razvan VOICU; Li, Mengran

    2011-01-01

    Brotherston and Simpson [citation] have formalized and investigated cyclic reasoning, reaching the important conclusion that it is at least as powerful as inductive reasoning (specifically, they showed that each inductive proof can be translated into a cyclic proof). We add to their investigation by proving the converse of this result, namely that each inductive proof can be translated into an inductive one. This, in effect, establishes the equivalence between first order cyclic and inductive...

  20. The Otto-engine-equivalent vehicle concept

    Science.gov (United States)

    Dowdy, M. W.; Couch, M. D.

    1978-01-01

    A vehicle comparison methodology based on the Otto-Engine Equivalent (OEE) vehicle concept is described. As an illustration of this methodology, the concept is used to make projections of the fuel economy potential of passenger cars using various alternative power systems. Sensitivities of OEE vehicle results to assumptions made in the calculational procedure are discussed. Factors considered include engine torque boundary, rear axle ratio, performance criteria, engine transient response, and transmission shift logic.

  1. Human Exposure to Electromagnetic Fields from Parallel Wireless Power Transfer Systems

    Directory of Open Access Journals (Sweden)

    Feng Wen

    2017-02-01

    Full Text Available The scenario of multiple wireless power transfer (WPT systems working closely, synchronously or asynchronously with phase difference often occurs in power supply for household appliances and electric vehicles in parking lots. Magnetic field leakage from the WPT systems is also varied due to unpredictable asynchronous working conditions. In this study, the magnetic field leakage from parallel WPT systems working with phase difference is predicted, and the induced electric field and specific absorption rate (SAR in a human body standing in the vicinity are also evaluated. Computational results are compared with the restrictions prescribed in the regulations established to limit human exposure to time-varying electromagnetic fields (EMFs. The results show that the middle region between the two WPT coils is safer for the two WPT systems working in-phase, and the peripheral regions are safer around the WPT systems working anti-phase. Thin metallic plates larger than the WPT coils can shield the magnetic field leakage well, while smaller ones may worsen the situation. The orientation of the human body will influence the maximum magnitude of induced electric field and its distribution within the human body. The induced electric field centralizes in the trunk, groin, and genitals with only one exception: when the human body is standing right at the middle of the two WPT coils working in-phase, the induced electric field focuses on lower limbs. The SAR value in the lungs always seems to be greater than in other organs, while the value in the liver is minimal. Human exposure to EMFs meets the guidelines of the International Committee on Non-Ionizing Radiation Protection (ICNIRP, specifically reference levels with respect to magnetic field and basic restrictions on induced electric fields and SAR, as the charging power is lower than 3.1 kW and 55.5 kW, respectively. These results are positive with respect to the safe applications of parallel WPT systems

  2. Human Exposure to Electromagnetic Fields from Parallel Wireless Power Transfer Systems

    Science.gov (United States)

    Wen, Feng; Huang, Xueliang

    2017-01-01

    The scenario of multiple wireless power transfer (WPT) systems working closely, synchronously or asynchronously with phase difference often occurs in power supply for household appliances and electric vehicles in parking lots. Magnetic field leakage from the WPT systems is also varied due to unpredictable asynchronous working conditions. In this study, the magnetic field leakage from parallel WPT systems working with phase difference is predicted, and the induced electric field and specific absorption rate (SAR) in a human body standing in the vicinity are also evaluated. Computational results are compared with the restrictions prescribed in the regulations established to limit human exposure to time-varying electromagnetic fields (EMFs). The results show that the middle region between the two WPT coils is safer for the two WPT systems working in-phase, and the peripheral regions are safer around the WPT systems working anti-phase. Thin metallic plates larger than the WPT coils can shield the magnetic field leakage well, while smaller ones may worsen the situation. The orientation of the human body will influence the maximum magnitude of induced electric field and its distribution within the human body. The induced electric field centralizes in the trunk, groin, and genitals with only one exception: when the human body is standing right at the middle of the two WPT coils working in-phase, the induced electric field focuses on lower limbs. The SAR value in the lungs always seems to be greater than in other organs, while the value in the liver is minimal. Human exposure to EMFs meets the guidelines of the International Committee on Non-Ionizing Radiation Protection (ICNIRP), specifically reference levels with respect to magnetic field and basic restrictions on induced electric fields and SAR, as the charging power is lower than 3.1 kW and 55.5 kW, respectively. These results are positive with respect to the safe applications of parallel WPT systems working

  3. Human-robot interaction: kinematics and muscle activity inside a powered compliant knee exoskeleton.

    Science.gov (United States)

    Knaepen, Kristel; Beyl, Pieter; Duerinck, Saartje; Hagman, Friso; Lefeber, Dirk; Meeusen, Romain

    2014-11-01

    Until today it is not entirely clear how humans interact with automated gait rehabilitation devices and how we can, based on that interaction, maximize the effectiveness of these exoskeletons. The goal of this study was to gain knowledge on the human-robot interaction, in terms of kinematics and muscle activity, between a healthy human motor system and a powered knee exoskeleton (i.e., KNEXO). Therefore, temporal and spatial gait parameters, human joint kinematics, exoskeleton kinetics and muscle activity during four different walking trials in 10 healthy male subjects were studied. Healthy subjects can walk with KNEXO in patient-in-charge mode with some slight constraints in kinematics and muscle activity primarily due to inertia of the device. Yet, during robot-in-charge walking the muscular constraints are reversed by adding positive power to the leg swing, compensating in part this inertia. Next to that, KNEXO accurately records and replays the right knee kinematics meaning that subject-specific trajectories can be implemented as a target trajectory during assisted walking. No significant differences in the human response to the interaction with KNEXO in low and high compliant assistance could be pointed out. This is in contradiction with our hypothesis that muscle activity would decrease with increasing assistance. It seems that the differences between the parameter settings of low and high compliant control might not be sufficient to observe clear effects in healthy subjects. Moreover, we should take into account that KNEXO is a unilateral, 1 degree-of-freedom device.

  4. Measuring Human Performance in Simulated Nuclear Power Plant Control Rooms Using Eye Tracking

    Energy Technology Data Exchange (ETDEWEB)

    Kovesdi, Casey Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rice, Brandon Charles [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bower, Gordon Ross [Idaho National Lab. (INL), Idaho Falls, ID (United States); Spielman, Zachary Alexander [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hill, Rachael Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States); LeBlanc, Katya Lee [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-11-01

    Control room modernization will be an important part of life extension for the existing light water reactor fleet. As part of modernization efforts, personnel will need to gain a full understanding of how control room technologies affect performance of human operators. Recent advances in technology enables the use of eye tracking technology to continuously measure an operator’s eye movement, which correlates with a variety of human performance constructs such as situation awareness and workload. This report describes eye tracking metrics in the context of how they will be used in nuclear power plant control room simulator studies.

  5. Development of NASA's Small Fission Power System for Science and Human Exploration

    Science.gov (United States)

    Gibson, Marc A.; Mason, Lee S.; Bowman, Cheryl L.; Poston, David I.; McClure, Patrick R.; Creasy, John; Robinson, Chris

    2015-01-01

    Exploration of our solar system has brought many exciting challenges to our nations scientific and engineering community over the past several decades. As we expand our visions to explore new, more challenging destinations, we must also expand our technology base to support these new missions. NASAs Space Technology Mission Directorate is tasked with developing these technologies for future mission infusion and continues to seek answers to many existing technology gaps. One such technology gap is related to compact power systems (1 kWe) that provide abundant power for several years where solar energy is unavailable or inadequate. Below 1 kWe, Radioisotope Power Systems have been the workhorse for NASA and will continue to be used for lower power applications similar to the successful missions of Voyager, Ulysses, New Horizons, Cassini, and Curiosity. Above 1 kWe, fission power systems become an attractive technology offering a scalable modular design of the reactor, shield, power conversion, and heat transport subsystems. Near term emphasis has been placed in the 1-10kWe range that lies outside realistic radioisotope power levels and fills a promising technology gap capable of enabling both science and human exploration missions. History has shown that development of space reactors is technically, politically, and financially challenging and requires a new approach to their design and development. A small team of NASA and DOE experts are providing a solution to these enabling FPS technologies starting with the lowest power and most cost effective reactor series named Kilopower that is scalable from approximately 1-10 kWe.

  6. Space nuclear power: technology, policy, and risk considerations in human missions to Mars.

    Science.gov (United States)

    Friedensen, V P

    1998-01-01

    There is a large discrepancy between potential needs for nuclear propulsion and power systems for the human exploration of Mars and the current status of R&D funding, public opinion, and governmental support for these technologies. Mission planners and spacecraft designers, energized by the recent claims of possible discovery of life on Mars and responding to increased public interest in the human exploration of Mars, frequently propose nuclear reactors and radioisotope thermoelectric generators (RTGs) for interplanetary spacecraft propulsion and for power supply on the surface of Mars. These plans and designs typically assume that reactors will be available "on-the-shelf," and do not take the extensive R&D costs required to develop such reactors into consideration. However, it is likely that current U.S. policies, if unchanged, will prohibit the launch of nuclear reactors and large RTGs in response to a perceived risk by the public.

  7. Human hippocampal increases in low-frequency power during associative prediction violations.

    Science.gov (United States)

    Chen, Janice; Dastjerdi, Mohammad; Foster, Brett L; LaRocque, Karen F; Rauschecker, Andreas M; Parvizi, Josef; Wagner, Anthony D

    2013-10-01

    Environmental cues often trigger memories of past events (associative retrieval), and these memories are a form of prediction about imminent experience. Learning is driven by the detection of prediction violations, when the past and present diverge. Using intracranial electroencephalography (iEEG), we show that associative prediction violations elicit increased low-frequency power (in the slow-theta range) in human hippocampus, that this low-frequency power increase is modulated by whether conditions allow predictions to be generated, that the increase rapidly onsets after the moment of violation, and that changes in low-frequency power are not present in adjacent perirhinal cortex. These data suggest that associative mismatch is computed within hippocampus when cues trigger predictions that are violated by imminent experience.

  8. The Power of Religious Organizations in Human Decision Processes: Analyzing Voting Behavior

    OpenAIRE

    Stadelmann, David; Portmann, Marco; TORGLER, Benno

    2013-01-01

    In Switzerland, two key church institutions - the Conference of Swiss Bishops (CSB) and the Federation of Protestant Churches (FPC) - make public recommendations on how to vote for certain referenda. We leverage this unique situation to directly measure religious organizations' power to shape human decision making. We employ an objective measure of voters' commitment to their religious organization to determine whether they are more likely to vote in line with this organization's recommendati...

  9. Energy harvesting from arterial blood pressure for powering embedded micro sensors in human brain

    Science.gov (United States)

    Nanda, Aditya; Karami, M. Amin

    2017-03-01

    This manuscript investigates energy harvesting from arterial blood pressure via the piezoelectric effect for the purpose of powering embedded micro-sensors in the human brain. One of the major hurdles in recording and measuring electrical data in the human nervous system is the lack of implantable and long term interfaces that record neural activity for extended periods of time. Recently, some authors have proposed micro sensors implanted deep in the brain that measure local electrical and physiological data which are then communicated to an external interrogator. This paper proposes a way of powering such interfaces. The geometry of the proposed harvester consists of a piezoelectric, circular, curved bimorph that fits into the blood vessel (specifically, the Carotid artery) and undergoes bending motion because of blood pressure variation. In addition, the harvester thickness is constrained such that it does not modify arterial wall dynamics. This transforms the problem into a known strain problem and the integral form of Gauss's law is used to obtain an equation relating arterial wall motion to the induced voltage. The theoretical model is validated by means of a Multiphysics 3D-FEA simulation comparing the harvested power at different load resistances. The peak harvested power achieved for the Carotid artery (proximal to Brain), with PZT-5H, was 11.7 μW. The peak power for the Aorta was 203.4 μW. Further, the variation of harvested power with variation in the harvester width and thickness, arterial contractility, and pulse rate is investigated. Moreover, potential application of the harvester as a chronic, implantable and real-time Blood pressure sensor is considered. Energy harvested via this mechanism will also have applications in long-term, implantable Brain Micro-stimulation.

  10. Improved protocol to purify untagged amelogenin - Application to murine amelogenin containing the equivalent P70→T point mutation observed in human amelogenesis imperfecta.

    Science.gov (United States)

    Buchko, Garry W; Shaw, Wendy J

    2015-01-01

    Amelogenin is the predominant extracellular protein responsible for converting carbonated hydroxyapatite into dental enamel, the hardest and most heavily mineralized tissue in vertebrates. Despite much effort, the precise mechanism by which amelogenin regulates enamel formation is not fully understood. To assist efforts aimed at understanding the biochemical mechanism of enamel formation, more facile protocols to purify recombinantly expressed amelogenin, ideally without any tag to assist affinity purification, are advantageous. Here we describe an improved method to purify milligram quantities of amelogenin that exploits its high solubility in 2% glacial acetic acid under conditions of low ionic strength. The method involves heating the frozen cell pellet for two 15min periods at ∼70°C with 2min of sonication in between, dialysis twice in 2% acetic acid (1:250 v/v), and reverse phase chromatography. A further improvement in yield is obtained by resuspending the frozen cell pellet in 6M guanidine hydrochloride in the first step. The acetic acid heating method is illustrated with a murine amelogenin containing the corresponding P70→T point mutation observed in an human amelogenin associated with amelogenesis imperfecta (P71T), while the guanidine hydrochloride heating method is illustrated with wild type murine amelogenin (M180). The self-assembly properties of P71T were probed by NMR chemical shift perturbation studies as a function of protein (0.1-1.8mM) and NaCl (0-367mM) concentration. Relative to similar studies with wild type murine amelogenin, P71T self-associates at lower protein or salt concentrations with the interactions initiated near the N-terminus.

  11. Human Power Vehicle Program. Final report, June 15, 1993--June 14, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Crowell, J.; Graves, P.

    1995-11-01

    The Human Power Vehicle Program was an intensive, five day a week, four week program designed to give middle school students the opportunity to ``be engineers``. During the month of July, Delta College, the Macro Michigan Multicultural Pre-Technical Education Partnership (M3PEP), and the United States Department of Energy sponsored a four-week learning experience in human-powered vehicles. This unique experience introduced students to the physiology of exercise, the mechanics of the bicycle, and the physics and mathematics of the bicycle. Students also participated in a three day bike tour. The Program used the Bike Lab facility at Delta College`s International Centre in Saginaw, Michigan. Students had the opportunity to explore the development and refinement of the bicycle design and to investigate it`s power machine-the human body. Interactive instruction was conducted in groups to assure that all students experienced the satisfaction of understanding the bicycle. The purpose of the Program was to increase minority students` awareness and appreciation of mathematics and science. The premise behind the Program was that engineers and scientists are made, not born. The Program was open to all minority youth, grades 8 and 9, and was limited to 25 students. Students were selected to participate based upon their interest, desire, maturity, and attitude.

  12. [Analysis of Electric Stress in Human Head in High-frequency Low-power Electromagnetic Environment].

    Science.gov (United States)

    Zhou, Yongjun; Zhang, Hui; Niu, Zhongqi

    2015-04-01

    Action of electromagnetic radiation exerting on human body has been a concerned issue for people. Because electromagnetic waves could generate an electric stress in a discontinuous medium, we used the finite difference time domain (FDTD) as calculation methods to calculate the electric stress and its distribution in human head caused by high-frequency low-power electromagnetic environment, which was generated by dual-band (900 MHz and 1 800 MHz) PIFA antennas with radiated power 1 W, and we then performed the safety evaluation of cell phone radiation from the angle whether the electric stress further reached the human hearing threshold. The result showed that there existed the electric stress at the interface of different permittivity organization caused by the two kinds of high-frequency low-power electromagnetic environment and the maximum electric stress was located at the interface between skin and air of the phone side, and the electric stress peak at skull did not reach the threshold of auditory caused by bone tissue conduction so that it can not produce auditory effects.

  13. Energy cost and mechanical efficiency of riding a human-powered recumbent bicycle.

    Science.gov (United States)

    Capelli, Carlo; Ardigo, Luca Paolo; Schena, Federico; Zamparo, Paola

    2008-10-01

    When dealing with human-powered vehicles, it is important to quantify the capability of converting metabolic energy in useful mechanical work by measuring mechanical efficiency. In this study, net mechanical efficiency (eta) of riding a recumbent bicycle on flat terrain and at constant speeds (v, 5.1-10.0 m/s) was calculated dividing mechanical work (w, J/m) by the corresponding energy cost (C(c), J/m). w and C(c) increased linearly with the speed squared: w = 9.41 + 0.156 . v(2); C(c) = 39.40 + 0.563 . v(2). eta was equal to 0.257 +/- 0.0245, i.e. identical to that of concentric muscular contraction. Hence, i) eta seems unaffected by the biomechanical arrangement of the human-vehicle system; ii) the efficiency of transmission seems to be close to 100%, suggesting that the particular biomechanical arrangement does not impair the transformation of metabolic energy in mechanical work. When dealing with human-powered vehicles, it is important to quantify mechanical efficiency (eta) of locomotion. eta of riding a recumbent bicycle was calculated dividing the mechanical work to the corresponding energy cost of locomotion; it was practically identical to that of concentric muscular contraction (0.257 +/- 0.0245), suggesting that the power transmission from muscles to pedals is unaffected by the biomechanical arrangement of the vehicle.

  14. Testing statistical hypotheses of equivalence

    CERN Document Server

    Wellek, Stefan

    2010-01-01

    Equivalence testing has grown significantly in importance over the last two decades, especially as its relevance to a variety of applications has become understood. Yet published work on the general methodology remains scattered in specialists' journals, and for the most part, it focuses on the relatively narrow topic of bioequivalence assessment.With a far broader perspective, Testing Statistical Hypotheses of Equivalence provides the first comprehensive treatment of statistical equivalence testing. The author addresses a spectrum of specific, two-sided equivalence testing problems, from the

  15. Pragmatic power

    CERN Document Server

    Eccles, William

    2008-01-01

    Pragmatic Power is focused on just three aspects of the AC electrical power system that supplies and moves the vast majority of electrical energy nearly everywhere in the world: three-phase power systems, transformers, and induction motors. The reader needs to have had an introduction to electrical circuits and AC power, although the text begins with a review of the basics of AC power. Balanced three-phase systems are studied by developing their single-phase equivalents. The study includes a look at how the cost of ""power"" is affected by reactive power and power factor. Transformers are cons

  16. Human performance tools in nuclear power plants. Introduction, implementation and experiences; Human Performance Tools in Kernkraftwerken. Einfuehrung, Umsetzung und Erfahrungen

    Energy Technology Data Exchange (ETDEWEB)

    Dexheimer, Kai; Bassing, Gerd [Dexcon Consulting GmbH, Neuhausen (Switzerland); Kreuzer, Peter [E.ON Kernkraft GmbH, Essenbach (Germany). Kernkraftwerk Isar

    2015-06-01

    The basis of safe nuclear power plant operation (NPP) and a strong safety culture is the professional application of Human Performance Optimisation Tools (HPO). HPO trainings have been carried out by German NPPs for a number of years and recently also by Swiss NPPs. This article describes the origination, the bases, experiences and thereby the special features of the HPO training programme applied by German NPP operators. Moreover, this article provides an outlook on future developments - in particular when considering the requirements of the ongoing phase out of nuclear energy in Germany.

  17. A nonlinear MEMS electrostatic kinetic energy harvester for human-powered biomedical devices

    Science.gov (United States)

    Lu, Y.; Cottone, F.; Boisseau, S.; Marty, F.; Galayko, D.; Basset, P.

    2015-12-01

    This article proposes a silicon-based electrostatic kinetic energy harvester with an ultra-wide operating frequency bandwidth from 1 Hz to 160 Hz. This large bandwidth is obtained, thanks to a miniature tungsten ball impacting with a movable proof mass of silicon. The motion of the silicon proof mass is confined by nonlinear elastic stoppers on the fixed part standing against two protrusions of the proof mass. The electrostatic transducer is made of interdigited-combs with a gap-closing variable capacitance that includes vertical electrets obtained by corona discharge. Below 10 Hz, the e-KEH offers 30.6 nJ per mechanical oscillation at 2 grms, which makes it suitable for powering biomedical devices from human motion. Above 10 Hz and up to 162 Hz, the harvested power is more than 0.5 μW with a maximum of 4.5 μW at 160 Hz. The highest power of 6.6 μW is obtained without the ball at 432 Hz, in accordance with a power density of 142 μW/cm3. We also demonstrate the charging of a 47-μF capacitor to 3.5 V used to power a battery-less wireless temperature sensor node.

  18. A nonlinear MEMS electrostatic kinetic energy harvester for human-powered biomedical devices

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Y.; Cottone, F.; Marty, F.; Basset, P., E-mail: p.basset@esiee.fr [Université Paris-Est/ESYCOM/ESIEE Paris, Noisy-le-Grand 93162 (France); Boisseau, S. [CEA, Leti, Minatec Campus, Grenoble 38054 (France); Galayko, D. [UPMC-Sorbonne Université/LIP 6, CNRS, Paris 75005 (France)

    2015-12-21

    This article proposes a silicon-based electrostatic kinetic energy harvester with an ultra-wide operating frequency bandwidth from 1 Hz to 160 Hz. This large bandwidth is obtained, thanks to a miniature tungsten ball impacting with a movable proof mass of silicon. The motion of the silicon proof mass is confined by nonlinear elastic stoppers on the fixed part standing against two protrusions of the proof mass. The electrostatic transducer is made of interdigited-combs with a gap-closing variable capacitance that includes vertical electrets obtained by corona discharge. Below 10 Hz, the e-KEH offers 30.6 nJ per mechanical oscillation at 2 g{sub rms}, which makes it suitable for powering biomedical devices from human motion. Above 10 Hz and up to 162 Hz, the harvested power is more than 0.5 μW with a maximum of 4.5 μW at 160 Hz. The highest power of 6.6 μW is obtained without the ball at 432 Hz, in accordance with a power density of 142 μW/cm{sup 3}. We also demonstrate the charging of a 47-μF capacitor to 3.5 V used to power a battery-less wireless temperature sensor node.

  19. Case Study on Human Walking during Wearing a Powered Prosthetic Device: Effectiveness of the System “Human-Robot”

    Directory of Open Access Journals (Sweden)

    Svetlana Grosu

    2014-01-01

    Full Text Available It is known that force exchanges between a robotic assistive device and the end-user have a direct impact on the quality and performance of a particular movement task. This knowledge finds a special reflective importance in prosthetic industry due to the close human-robot collaboration. Although lower-extremity prostheses are currently better able to provide assistance as their upper-extremity counterparts, specific locomotion problems still remain. In a framework of this contribution the authors introduce the multibody dynamic modelling approach of the transtibial prosthesis wearing on a human body model. The obtained results are based on multibody dynamic simulations against the real experimental data using AMP-Foot 2.0, an energy efficient powered transtibial prosthesis for actively assisted walking of amputees.

  20. Development of human reliability analysis methodology and its computer code during low power/shutdown operation

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Chang Hyun; You, Young Woo; Huh, Chang Wook; Kim, Ju Yeul; Kim Do Hyung; Kim, Yoon Ik; Yang, Hui Chang [Seoul National University, Seoul (Korea, Republic of); Jae, Moo Sung [Hansung University, Seoul (Korea, Republic of)

    1997-07-01

    The objective of this study is to develop the appropriate procedure that can evaluate the human error in LP/S(lower power/shutdown) and the computer code that calculate the human error probabilities(HEPs) using this framework. The assessment of applicability of the typical HRA methodologies to LP/S is conducted and a new HRA procedure, SEPLOT (Systematic Evaluation Procedure for LP/S Operation Tasks) which presents the characteristics of LP/S is developed by selection and categorization of human actions by reviewing present studies. This procedure is applied to evaluate the LOOP(Loss of Off-site Power) sequence and the HEPs obtained by using SEPLOT are used to quantitative evaluation of the core uncovery frequency. In this evaluation one of the dynamic reliability computer codes, DYLAM-3 which has the advantages against the ET/FT is used. The SEPLOT developed in this study can give the basis and arrangement as to the human error evaluation technique. And this procedure can make it possible to assess the dynamic aspects of accidents leading to core uncovery applying the HEPs obtained by using the SEPLOT as input data to DYLAM-3 code, Eventually, it is expected that the results of this study will contribute to improve safety in LP/S and reduce uncertainties in risk. 57 refs. 17 tabs., 33 figs. (author)

  1. KEPCO‧s Activity to Power-Engineer Human Resource Development

    Science.gov (United States)

    Kobashi, Kazushi

    While business environment changes a lot, in order to aim at realization of “what we want the Group to look like in 2030” , it is necessary to cultivate human resources with a strong sense of mission. We need to prepare an opportunity to teach and to be taught, in order to cultivate resources and a measure for connecting every person‧s growth to growth of a company. In chapter one, we show Five Trends for attaining what KANSAI Electric Power Corporation wants to be and explain the importance of human resource development under the changing environment. In chapter two, we explain the fundamental policy of human resource cultivation and describe the development plan and the facilities for training based on the policy in chapter two. In chapter three, we express the specific efforts in the field of maintenance, construction, and operation at the department of Engineering and Operation.

  2. Human reliability analysis in low power and shut-down probabilistic safety assessment: Outcomes of an international initiative

    Directory of Open Access Journals (Sweden)

    Manna Giustino

    2012-01-01

    Full Text Available Since the beginning of the nuclear power generation, human performance has been a very important factor in all phases of the plant lifecycle: design, commissioning, operation, maintenance, surveillance, modification, and decommissioning. This aspect has been confirmed by the operating experience. A workshop was organized by the IAEA and the Joint Research Centre of the European Commission, on Harmonization of low power and shutdown probabilistic safety assessment for WWER nuclear power plants. One of the major objectives of the Workshop was to provide a comparison of the approaches and results of human reliability analyses for WWER 440 and WWER 1000, and gain insights for future application of human reliability analyses in Low Power and Shutdown scenarios. This paper provides the insights and conclusions of the workshops concerning human reliability analyses and human factors.

  3. Saponification equivalent of dasamula taila.

    Science.gov (United States)

    Saxena, R B

    1994-07-01

    Saponification equivalent values of Dasamula taila are very useful for the technical and analytical work. It gives the mean molecular weight of the glycerides and acids present in Dasamula Taila. Saponification equivalent values of Dasamula taila are reported in different packings.

  4. General Dynamic Equivalent Modeling of Microgrid Based on Physical Background

    Directory of Open Access Journals (Sweden)

    Changchun Cai

    2015-11-01

    Full Text Available Microgrid is a new power system concept consisting of small-scale distributed energy resources; storage devices and loads. It is necessary to employ a simplified model of microgrid in the simulation of a distribution network integrating large-scale microgrids. Based on the detailed model of the components, an equivalent model of microgrid is proposed in this paper. The equivalent model comprises two parts: namely, equivalent machine component and equivalent static component. Equivalent machine component describes the dynamics of synchronous generator, asynchronous wind turbine and induction motor, equivalent static component describes the dynamics of photovoltaic, storage and static load. The trajectory sensitivities of the equivalent model parameters with respect to the output variables are analyzed. The key parameters that play important roles in the dynamics of the output variables of the equivalent model are identified and included in further parameter estimation. Particle Swarm Optimization (PSO is improved for the parameter estimation of the equivalent model. Simulations are performed in different microgrid operation conditions to evaluate the effectiveness of the equivalent model of microgrid.

  5. Unitary equivalence of quantum walks

    Energy Technology Data Exchange (ETDEWEB)

    Goyal, Sandeep K., E-mail: sandeep.goyal@ucalgary.ca [School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, 4000 Durban (South Africa); Konrad, Thomas [School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, 4000 Durban (South Africa); National Institute for Theoretical Physics (NITheP), KwaZulu-Natal (South Africa); Diósi, Lajos [Wigner Research Centre for Physics, Institute for Particle and Nuclear Physics, H-1525 Budapest 114, P.O.B. 49 (Hungary)

    2015-01-23

    Highlights: • We have found unitary equivalent classes in coined quantum walks. • A single parameter family of coin operators is sufficient to realize all simple one-dimensional quantum walks. • Electric quantum walks are unitarily equivalent to time dependent quantum walks. - Abstract: A simple coined quantum walk in one dimension can be characterized by a SU(2) operator with three parameters which represents the coin toss. However, different such coin toss operators lead to equivalent dynamics of the quantum walker. In this manuscript we present the unitary equivalence classes of quantum walks and show that all the nonequivalent quantum walks can be distinguished by a single parameter. Moreover, we argue that the electric quantum walks are equivalent to quantum walks with time dependent coin toss operator.

  6. Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment.

    Science.gov (United States)

    Xiao, Li; Miwa, Nobuhiko

    2017-04-01

    The aim of the present study is to investigate protective effects of hydrogen-rich water (HW) against reactive oxygen species (ROS)-induced cellular harmful events and cell death in human gingival fibroblasts (HGF) and three-dimensional (3D-) gingival tissue equivalents. HW was prepared with a magnesium stick in 600-mL double distilled water (DDW) overnight. Dissolved hydrogen was about 1460 ± 50 μg/L versus approximately 1600 μg/L for the saturated hydrogen. Under cell-free conditions, HW, dose-dependently, significantly scavenged peroxyl radicals (ROO·) derived from 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). Extract from HW-treated HGF cells scavenged ROO· more markedly than that from DDW-treated cells, suggesting that HW can increase the intracellular antioxidant capacity. Hydrogen peroxide dose-dependently increased the intracellular ROS generation, which was significantly repressed by HW, both in the cytoplasm and nuclei. LIVE/DEAD staining and our original cell viability dye-extraction assay showed that HW significantly protected HGF cells from hydrogen peroxide-induced cell death. Hydrogen peroxide also diminished the contents of intracellular glutathione, which were appreciably relieved by HW-pretreatment. Additionally, HW noticeably prevented cumene hydroperoxide-induced generation of cellular ROS in epidermis parts of 3D-gingival equivalents. The in vitro scratch assay showed that HW was able to diminish physical injury-induced ROS generation and promote wound healing in HGF cell monolayer sheets. In summary, HW was able to increase intracellular antioxidative capacity and to protect cells and tissue from oxidative damage. Thus, HW might be used for prevention/treatment of oxidative stress-related diseases.

  7. New method for electric equivalents synthesis expressed in digital filters form for transitory simulations in real time for great power nets; Novo metodo para sintese de equivalentes eletricos a filtros digitais para simulacao de transitorios em tempo real em redes eletricas de grande porte

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Clever [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Nucleo de Desenvolvimento Cientifico e Tecnologico em Descargas Atmosfericas]. E-mail: clever@cpdee.ufmg.br; Carneiro Junior, Sandoval [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia; Szczupak, Jacques [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil)

    2001-07-01

    This article presents a new method to obtain subtransmission nets equivalents, expressed in form of digital filters of finite answer to the impulse, for transitory simulations in great power nets. Initially, it has been made considerations in the way of obtaining these filters, showing that they basically have been synthesized from the impedance and admittance functions of the secondary electric net to be processed in terms of equivalents in the domain of the w analogical frequency. It also is shown the transference technique to the time domain, in which it is used the z plane of the digital frequencies as an intermediate plane, being obtained from this way a set of equations susceptible of being implemented in program of transitory simulation in the time domain. The evaluation of this new method and evaluation of the reduction effect in the order of representative filters of the equivalents, are executed through the comparison of simulations which use the new technique together with other ones coming from EMTP. The obtained replies have demonstrated the effectiveness of the proposed method, opening new possibilities for transitory simulations in great power nets.

  8. Effects of temperature on the maximal instantaneous muscle power of humans.

    Science.gov (United States)

    Ferretti, G; Ishii, M; Moia, C; Cerretelli, P

    1992-01-01

    The maximal instantaneous muscle power (wi,max) probably reflects the maximal rate of adenosine 5'-triphosphate (ATP) hydrolysis (ATPmax), a temperature-dependent variable, which gives rise to the hypothesis that temperature, by affecting ATPmax, may also influence wi,max. This hypothesis was tested on six subjects, whose vastus lateralis muscle temperature (Tmuscle) was monitored by a thermocouple inserted approximately 3 cm below the skin surface. The Wi,max was determined during a series of high jumps off both feet on a force platform before and after immersion up to the abdomen for 90 min in a temperature controlled (T = 20 +/- 0.1 degrees C) water bath. Control Tmuscle was 35.8 +/- 0.7 degrees C, with control Wi,max being 51.6 (SD 8.7) W.kg-1. After cold exposure, Tmuscle decreased by about 8 degrees C, whereas wi,max 27% lower. The temperature dependence of Wi,max was found to be less (Q10 less than 1.5, where Q10 is the temperature coefficient as calculated in other studies) than reported in the literature for ATPmax. Such a low Q10 may reflect an increase in the mechanical equivalent of ATP splitting, as a consequence of the reduced velocity of muscle contraction occurring at low Tmuscle.

  9. "Green earth, women's power, human liberation": women in peasant movements in India.

    Science.gov (United States)

    Omvedt, G

    1992-01-01

    The experience of 2 peasant women's movements in India's state of Maharashtra--Stri Mukti Sangharsh and Shetkari Mahila Aghadi--highlights the potential power of women in resisting capitalist exploitation of peasant and forest-dwelling communities. The former organization is the women's branch of a movement that is resisting the ecological destruction and displacement of peasants and tribal people resulting from development projects such as dam construction; the latter addresses the demand for fair prices for agricultural produce and inequities created by a market economy. Both are mass-based, self-financed people's movements unconnected with any political party. Although women are under-represented in the formal decision-making bodies of the parent organizations, they are struggling to become a central force in the development of alternative technology and agriculture. In 1990, Stri Mukti Sangharsh activists devised a new slogan--green earth, women's power, human liberation--summarizing this process. Similarly, Shetkari Mahila Aghadi calls upon women to monopolize political power and runs all-women panels in district council elections. These campaigns have challenged women's exclusion from ownership of land in spite of laws granting property rights and placed the issues of women's health and nutrition on the political agenda. Moreover, peasant women have played a leading role in the current experimentation with energy-recycling, regenerative, low-input agricultural development. Together, these developments may provide Indian women with the power to recover their former centrality in agricultural decision-making and production.

  10. Establishing a value chain for human factors in nuclear power plantcontrol room modernization

    Energy Technology Data Exchange (ETDEWEB)

    Joe, Jeffrey Clark [Idaho National Laboratory; Thomas, Kenneth David [Idaho National Laboratory; Boring, Ronald Laurids [Idaho National Laboratory

    2015-07-01

    Commercial nuclear power plants in the United States (U.S.) have operated reliably and efficiently for decades. With the life extensions of plants now being planned for operation beyond their original operating licenses, there are opportunities to achieve even greater efficiencies, while maintaining high operational reliabilities, with strategic, risk- and economically-informed, upgrades to plant systems and infrastructure. The U.S. Department of Energy’s Light Water Reactor Sustainability (LWRS) program supports the commercial nuclear industry’s modernization efforts through research and development (R&D) activities across many areas to help establish the technical and economic bases for modernization activities. The Advanced Instrumentation, Information, and Control Systems Technologies pathway is one R&D focus area for the LWRS program, and has researchers at Idaho National Laboratory working with select utility partners to use human factors and instrumentation and controls R&D to help modernize the plant’s main control room. However, some in the nuclear industry have not been as enthusiastic about using human factors R&D to inform life extension decision making. Part of the reason for this may stem from uncertainty decision-makers have regarding how human factors fits into the value chain for nuclear power plant control room modernization. This paper reviews past work that has attempted to demonstrate the value of human factors, and then describes the value chain concept, how it applies to control room modernization, and then makes a case for how and why human factors is an essential link in the modernization value chain.

  11. On the role of exchange of power and information signals in control and stability of the human-robot interaction

    Science.gov (United States)

    Kazerooni, H.

    1991-01-01

    A human's ability to perform physical tasks is limited, not only by his intelligence, but by his physical strength. If, in an appropriate environment, a machine's mechanical power is closely integrated with a human arm's mechanical power under the control of the human intellect, the resulting system will be superior to a loosely integrated combination of a human and a fully automated robot. Therefore, we must develop a fundamental solution to the problem of 'extending' human mechanical power. The work presented here defines 'extenders' as a class of robot manipulators worn by humans to increase human mechanical strength, while the wearer's intellect remains the central control system for manipulating the extender. The human, in physical contact with the extender, exchanges power and information signals with the extender. The aim is to determine the fundamental building blocks of an intelligent controller, a controller which allows interaction between humans and a broad class of computer-controlled machines via simultaneous exchange of both power and information signals. The prevalent trend in automation has been to physically separate the human from the machine so the human must always send information signals via an intermediary device (e.g., joystick, pushbutton, light switch). Extenders, however are perfect examples of self-powered machines that are built and controlled for the optimal exchange of power and information signals with humans. The human wearing the extender is in physical contact with the machine, so power transfer is unavoidable and information signals from the human help to control the machine. Commands are transferred to the extender via the contact forces and the EMG signals between the wearer and the extender. The extender augments human motor ability without accepting any explicit commands: it accepts the EMG signals and the contact force between the person's arm and the extender, and the extender 'translates' them into a desired position. In

  12. Lightning discharges and discharges from overhead power lines with human burn injuries as consequences

    Directory of Open Access Journals (Sweden)

    Javor Sanja

    2013-01-01

    Full Text Available Discharges from overhead power lines and lightning discharges may severely endanger human life and health. If non-lethal, burn injuries may also last for a lifetime, so as Lichtenberg figures caused by lightning discharges. Some accidents with burns are discussed in this paper and recommendations given for safety reasons. Specific energy transferred by typical lightning strokes currents given in the standard IEC 62305 is calculated. The aim of the paper is to suggest a simple expression for the estimation of safe approach distances to overhead lines, especially if high temperatures and changes in terrain reduced the secure height above ground, or if carrying elevated objects. Results of these calculations are compared to safe approach distances given in regulations of different countries. Safe distances from railway power lines are also considered.

  13. The extreme relativity of perception: A new contextual effect modulates human resolving power.

    Science.gov (United States)

    Namdar, Gal; Ganel, Tzvi; Algom, Daniel

    2016-04-01

    The authors report the discovery of a new effect of context that modulates human resolving power with respect to an individual stimulus. They show that the size of the difference threshold or the just noticeable difference around a standard stimulus depends on the range of the other standards tested simultaneously for resolution within the same experimental session. The larger this range, the poorer the resolving power for a given standard. The authors term this effect the range of standards effect (RSE). They establish this result both in the visual domain for the perception of linear extent, and in the somatosensory domain for the perception of weight. They discuss the contingent nature of stimulus resolution in perception and psychophysics and contrast it with the immunity to contextual influences of visually guided action. (c) 2016 APA, all rights reserved).

  14. Influence of Power Delivery Timing on the Energetics and Biomechanics of Humans Wearing a Hip Exoskeleton.

    Science.gov (United States)

    Young, Aaron J; Foss, Jessica; Gannon, Hannah; Ferris, Daniel P

    2017-01-01

    A broad goal in the field of powered lower limb exoskeletons is to reduce the metabolic cost of walking. Ankle exoskeletons have successfully achieved this goal by correctly timing a plantarflexor torque during late stance phase. Hip exoskeletons have the potential to assist with both flexion and extension during walking gait, but the optimal timing for maximally reducing metabolic cost is unknown. The focus of our study was to determine the best assistance timing for applying hip assistance through a pneumatic exoskeleton on human subjects. Ten non-impaired subjects walked with a powered hip exoskeleton, and both hip flexion and extension assistance were separately provided at different actuation timings using a simple burst controller. The largest average across-subject reduction in metabolic cost for hip extension was at 90% of the gait cycle (just prior to heel contact) and for hip flexion was at 50% of the gait cycle; this resulted in an 8.4 and 6.1% metabolic reduction, respectively, compared to walking with the unpowered exoskeleton. However, the ideal timing for both flexion and extension assistance varied across subjects. When selecting the assistance timing that maximally reduced metabolic cost for each subject, average metabolic cost for hip extension was 10.3% lower and hip flexion was 9.7% lower than the unpowered condition. When taking into account user preference, we found that subject preference did not correlate with metabolic cost. This indicated that user feedback was a poor method of determining the most metabolically efficient assistance power timing. The findings of this study are relevant to developers of exoskeletons that have a powered hip component to assist during human walking gait.

  15. Influence of Power Delivery Timing on the Energetics and Biomechanics of Humans Wearing a Hip Exoskeleton

    Science.gov (United States)

    Young, Aaron J.; Foss, Jessica; Gannon, Hannah; Ferris, Daniel P.

    2017-01-01

    A broad goal in the field of powered lower limb exoskeletons is to reduce the metabolic cost of walking. Ankle exoskeletons have successfully achieved this goal by correctly timing a plantarflexor torque during late stance phase. Hip exoskeletons have the potential to assist with both flexion and extension during walking gait, but the optimal timing for maximally reducing metabolic cost is unknown. The focus of our study was to determine the best assistance timing for applying hip assistance through a pneumatic exoskeleton on human subjects. Ten non-impaired subjects walked with a powered hip exoskeleton, and both hip flexion and extension assistance were separately provided at different actuation timings using a simple burst controller. The largest average across-subject reduction in metabolic cost for hip extension was at 90% of the gait cycle (just prior to heel contact) and for hip flexion was at 50% of the gait cycle; this resulted in an 8.4 and 6.1% metabolic reduction, respectively, compared to walking with the unpowered exoskeleton. However, the ideal timing for both flexion and extension assistance varied across subjects. When selecting the assistance timing that maximally reduced metabolic cost for each subject, average metabolic cost for hip extension was 10.3% lower and hip flexion was 9.7% lower than the unpowered condition. When taking into account user preference, we found that subject preference did not correlate with metabolic cost. This indicated that user feedback was a poor method of determining the most metabolically efficient assistance power timing. The findings of this study are relevant to developers of exoskeletons that have a powered hip component to assist during human walking gait. PMID:28337434

  16. Four children and Yale: the making of a human geneticist: the Grover Powers lecture 2014.

    Science.gov (United States)

    Rosenberg, Leon E

    2014-09-01

    Dr. Leon E. Rosenberg delivered the following presentation as the Grover Powers Lecturer on May 14, 2014, which served as the focal point of his return to his "adult home" as a Visiting Professor in the Department of Pediatrics. Grover F. Powers, MD, was one of the most influential figures in American Pediatrics and certainly the leader who created the modern Department of Pediatrics at Yale when he was recruited in 1921 from Johns Hopkins and then served as its second chairman from 1927 to 1951. Dr. Powers was an astute clinician and compassionate physician and fostered and shaped the careers of countless professors, chairs, and outstanding pediatricians throughout the country. This lectureship has continued yearly since it first honored Dr. Powers in 1956. The selection of Dr. Rosenberg for this honor recognizes his seminal role at Yale and throughout the world in the fostering and cultivating of the field of human genetics. Dr. Rosenberg served as the inaugural Chief of a joint Division of Medical Genetics in the Departments of Pediatrics and Internal Medicine; he became Chair when this attained Departmental status. Then he served as Dean of the Medical School from 1984 to 1991, before he became President of the Pharmaceutical Research Institute at Bristol-Myers Squibb and later Senior Molecular Biologist and Professor at Princeton University, until his recent retirement. Dr. Rosenberg has received numerous honors that include the Borden Award from the American Academy of Pediatrics, the McKusick Leadership Award from the American Society for Human Genetics, and election to the Institute of Medicine and the National Academy of Sciences.

  17. Approved Drug Products with Therapuetic Equivalence Evaluations (Orange Book)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on...

  18. Approved Drug Products with Therapuetic Equivalence Evaluations (Orange Book)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on...

  19. Aerodynamic design of the Cal Poly Da Vinci Human-Powered Helicopter

    Science.gov (United States)

    Larwood, Scott; Saiki, Neal

    1990-01-01

    This paper will discuss the methodology used in designing the rotor and drive propellers for the third generation Cal Poly Da Vinci Human-Powered Helicopter. The rotor was designed using a lifting surface, uniform inflow hover analysis code and the propeller was designed using a minimum induced-loss method. Construction, geometry, and operating considerations are discussed as they impact the designs. Optimization of the design performance is also explained. The propellers were tested in a wind tunnel and results are compared with theoretical data. Successful flight tests of the Da Vinci III are discussed.

  20. Human speech articulator measurements using low power, 2GHz Homodyne sensors

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, T; Burnett, G C; Holzrichter, J F

    1999-06-29

    Very low power, short-range microwave ''radar-like'' sensors can measure the motions and vibrations of internal human speech articulators as speech is produced. In these animate (and also in inanimate acoustic systems) microwave sensors can measure vibration information associated with excitation sources and other interfaces. These data, together with the corresponding acoustic data, enable the calculation of system transfer functions. This information appears to be useful for a surprisingly wide range of applications such as speech coding and recognition, speaker or object identification, speech and musical instrument synthesis, noise cancellation, and other applications.

  1. Full Static Output Feedback Equivalence

    Directory of Open Access Journals (Sweden)

    Aristotle G. Yannakoudakis

    2013-01-01

    Full Text Available We present a constructive solution to the problem of full output feedback equivalence, of linear, minimal, time-invariant systems. The equivalence relation on the set of systems is transformed to another on the set of invertible block Bezout/Hankel matrices using the isotropy subgroups of the full state feedback group and the full output injection group. The transformation achieving equivalence is calculated solving linear systems of equations. We give a polynomial version of the results proving that two systems are full output feedback equivalent, if and only if they have the same family of generalized Bezoutians. We present a new set of output feedback invariant polynomials that generalize the breakaway polynomial of scalar systems.

  2. The modification of specific absorption rates in interstitial microwave hyperthermia via tissue-equivalent material bolus.

    Science.gov (United States)

    Sundararaman, S; Denman, D L; Legorreta, R A; Foster, A E; Redmond, K P; Elson, H R; Born, A M; Samaratunga, R C; Lewis, G C; Kereiakes, J G

    1990-09-01

    Patterns of specific absorption rates generated by interstitial, microwave antenna arrays must be experimentally ascertained and quantified to facilitate their clinical incorporation. Phantom studies involved the use of four single-gap, coaxial antennas oriented in a 2 cm square array. These dipoles were driven in phase by a microwave generator at a frequency of 915 MHz. The inherent limitations in modifying the specific absorption rate patterns were addressed with the addition of bolus to the phantom. These additions of Guy's muscle tissue-equivalent material were made either proximal or distal to the phantom proper. Experiments conducted in the presence and absence of tissue-equivalent material bolus showed the ability to achieve broader bands of 50% power deposition in certain bolus conditions. These heating patterns were sufficiently reproducible and predictable to warrant clinical application of the bolus addition. A through-and-through method of catheter implantation allowed for bolus addition when deemed necessary. Treatments with veterinary and human patients using the bolus method to modify heating patterns yielded augmented patterns of power deposition. The effective length of the antennas that would radiate efficiently was essentially broadened via introduction of a microwave-interacting medium. As a result of the tissue equivalent material's ability to absorb microwave power, it was necessary to interpose minimally-interactive styrofoam spacers to limit heat transfer effects at the tissue-bolus interfaces.

  3. Results of a nuclear power plant application of A New Technique for Human Error Analysis (ATHEANA)

    Energy Technology Data Exchange (ETDEWEB)

    Whitehead, D.W.; Forester, J.A. [Sandia National Labs., Albuquerque, NM (United States); Bley, D.C. [Buttonwood Consulting, Inc. (United States)] [and others

    1998-03-01

    A new method to analyze human errors has been demonstrated at a pressurized water reactor (PWR) nuclear power plant. This was the first application of the new method referred to as A Technique for Human Error Analysis (ATHEANA). The main goals of the demonstration were to test the ATHEANA process as described in the frame-of-reference manual and the implementation guideline, test a training package developed for the method, test the hypothesis that plant operators and trainers have significant insight into the error-forcing-contexts (EFCs) that can make unsafe actions (UAs) more likely, and to identify ways to improve the method and its documentation. A set of criteria to evaluate the success of the ATHEANA method as used in the demonstration was identified. A human reliability analysis (HRA) team was formed that consisted of an expert in probabilistic risk assessment (PRA) with some background in HRA (not ATHEANA) and four personnel from the nuclear power plant. Personnel from the plant included two individuals from their PRA staff and two individuals from their training staff. Both individuals from training are currently licensed operators and one of them was a senior reactor operator on shift until a few months before the demonstration. The demonstration was conducted over a 5-month period and was observed by members of the Nuclear Regulatory Commission`s ATHEANA development team, who also served as consultants to the HRA team when necessary. Example results of the demonstration to date, including identified human failure events (HFEs), UAs, and EFCs are discussed. Also addressed is how simulator exercises are used in the ATHEANA demonstration project.

  4. Precision of estimated snow water equivalent (SWE) derived from the new sensor snow power in Quebec (Canada); Precision de l'estimation de l'equivalent en eau de la neige obtenue avec la sonde snowpower au Quebec (Canada)

    Energy Technology Data Exchange (ETDEWEB)

    Niang, M.; Durand, Y. [Meteo France/CEN, 38 - Saint Martin d' Heres (France); Bernier, M. [Institut National de la Recherche Scientifique (INRS-ETE), Centre Eau, Terre et Environnement, Quebec (Canada); Van Bochove, E. [Agriculture et Agroalimentaire, Quebec (Canada)

    2006-07-01

    This paper is about the accuracy gotten to determine the Snow Water Equivalent (SWE) and the snow moisture using a new in situ sensor, the 'SNOWPOWER' probe. This sensor can estimate simultaneously the snow density and the snow moisture by measuring the dielectric constant of the snow at low and high frequencies along a 10 to 20-m long flat-band cable. The high frequencies signal is measured with a Time Domain Reflectometer (TDR), the low frequencies signal is measured with an impedance analyser. The proposed original methodology allows also to extract the snow height and then to use the sensor for SWE estimation. This paper gives the results of one experimental season, the winter 2003-2004, in a agricultural field located near Quebec City in Canada (48 deg. 28'12''N, 71 deg. 10'48''W). The estimated derived from the new automatic sensor are compared with manual measurements of the snow properties. The results show a good estimation of the snow liquid water content (0.40% volumetric) and the SWE (14.07 mm). However, results show the importance of the selection of the low frequency and of the algorithm for the snow temperature extrapolation for the accuracy of the estimation. Finally, we discuss the integration of the sensor's densities to the EQeau model for mapping the SWE using radar satellite data. (authors)

  5. Does ankle joint power reflect type of muscle action of soleus and gastrocnemius during walking in cats and humans?

    Science.gov (United States)

    Cronin, Neil J; Prilutsky, Boris I; Lichtwark, Glen A; Maas, Huub

    2013-04-26

    The main objective of this paper is to highlight the difficulties of identifying shortening and lengthening contractions based on analysis of power produced by resultant joint moments. For that purpose, we present net ankle joint powers and muscle fascicle/muscle-tendon unit (MTU) velocities for medial gastrocnemius (MG) and soleus (SO) muscles during walking in species of different size (humans and cats). For the cat, patterns of ankle joint power and MTU velocity of MG and SO during stance were similar: negative power (ankle moment×angular velocitypower (generation of mechanical energy) was found during MTU shortening. This was also found for the general fascicle velocity pattern in SO. In contrast, substantial differences between ankle joint power and fascicle velocity patterns were observed for MG muscle. In humans, like cats, the patterns of ankle joint power and MTU velocity of SO and MG were similar. Unlike the cat, there were substantial differences between patterns of fascicle velocity and ankle joint power during stance in both muscles. These results indicate that during walking, only a small fraction of mechanical work of the ankle moment is either generated or absorbed by the muscle fascicles, thus confirming the contribution of in-series elastic structures and/or energy transfer via two-joint muscles. We conclude that ankle joint negative power does not necessarily indicate eccentric action of muscle fibers and that positive power cannot be exclusively attributed to muscle concentric action, especially in humans.

  6. Learning to modulate the partial powers of a single sEMG power spectrum through a novel human-computer interface.

    Science.gov (United States)

    Skavhaug, Ida-Maria; Lyons, Kenneth R; Nemchuk, Anna; Muroff, Shira D; Joshi, Sanjay S

    2016-06-01

    New human-computer interfaces that use bioelectrical signals as input are allowing study of the flexibility of the human neuromuscular system. We have developed a myoelectric human-computer interface which enables users to navigate a cursor to targets through manipulations of partial powers within a single surface electromyography (sEMG) signal. Users obtain two-dimensional control through simultaneous adjustments of powers in two frequency bands within the sEMG spectrum, creating power profiles corresponding to cursor positions. It is unlikely that these types of bioelectrical manipulations are required during routine muscle contractions. Here, we formally establish the neuromuscular ability to voluntarily modulate single-site sEMG power profiles in a group of naïve subjects under restricted and controlled conditions using a wrist muscle. All subjects used the same pre-selected frequency bands for control and underwent the same training, allowing a description of the average learning progress throughout eight sessions. We show that subjects steadily increased target hit rates from 48% to 71% and exhibited greater control of the cursor's trajectories following practice. Our results point towards an adaptable neuromuscular skill, which may allow humans to utilize single muscle sites as limited general-purpose signal generators. Ultimately, the goal is to translate this neuromuscular ability to practical interfaces for the disabled by using a spared muscle to control external machines.

  7. Expert judgment in analysis of human and organizational behaviour at nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Reiman, L. [Finnish Centre for Radiation and Nuclear Safety, Helsinki (Finland). Dept. of Nuclear Safety

    1994-12-01

    Probabilistic safety assessment (PSA) of a nuclear power plant includes an assessment of the probability of each event sequence that can lead to a reactor core damage and of their consequences. Despite increasing maturity of PSA methods, there are still several problems in their use. These include the assessment of human reliability and the impact of organizational factors on plant safety. The assessment of both these issues is based on expert judgment. Therefore, the use of expert judgment in analysis of human and organizational behaviour was studied theoretically and in practical case studies in this thesis. Human errors were analysed in two case studies. In the first study cognitive actions of control room operators were analysed. For this purpose methods were developed for the qualitative and quantitative phases of the analysis. Errors of test and maintenance personnel were analysed in the second case study. Especially the dependence of errors between sequential tasks performed in redundant subsystems of a safety system was studied. A method to assess organizational behaviour was developed and applied in the third case study. The three case studies demonstrated that expert judgment can be used in the analysis of human reliability and organizational behaviour taking into account the observations made and the remarks presented in the study. However, significant uncertainties are related with expert judgment. Recommendations are presented concerning the use of different methods. Also, some insights are presented into how reliance on expert judgment could be reduced. (241 refs., 20 figs., 36 tabs.).

  8. A HUMAN FACTORS META MODEL FOR U.S. NUCLEAR POWER PLANT CONTROL ROOM MODERNIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Joe, Jeffrey C.

    2017-03-01

    Over the last several years, the United States (U.S.) Department of Energy (DOE) has sponsored human factors research and development (R&D) and human factors engineering (HFE) activities through its Light Water Reactor Sustainability (LWRS) program to modernize the main control rooms (MCR) of commercial nuclear power plants (NPP). Idaho National Laboratory (INL), in partnership with numerous commercial nuclear utilities, has conducted some of this R&D to enable the life extension of NPPs (i.e., provide the technical basis for the long-term reliability, productivity, safety, and security of U.S. NPPs). From these activities performed to date, a human factors meta model for U.S. NPP control room modernization can now be formulated. This paper discusses this emergent HFE meta model for NPP control room modernization, with the goal of providing an integrated high level roadmap and guidance on how to perform human factors R&D and HFE for those in the U.S. nuclear industry that are engaging in the process of upgrading their MCRs.

  9. Computational Fluid Dynamics Ventilation Study for the Human Powered Centrifuge at the International Space Station

    Science.gov (United States)

    Son, Chang H.

    2012-01-01

    The Human Powered Centrifuge (HPC) is a facility that is planned to be installed on board the International Space Station (ISS) to enable crew exercises under the artificial gravity conditions. The HPC equipment includes a "bicycle" for long-term exercises of a crewmember that provides power for rotation of HPC at a speed of 30 rpm. The crewmember exercising vigorously on the centrifuge generates the amount of carbon dioxide of about two times higher than a crewmember in ordinary conditions. The goal of the study is to analyze the airflow and carbon dioxide distribution within Pressurized Multipurpose Module (PMM) cabin when HPC is operating. A full unsteady formulation is used for airflow and CO2 transport CFD-based modeling with the so-called sliding mesh concept when the HPC equipment with the adjacent Bay 4 cabin volume is considered in the rotating reference frame while the rest of the cabin volume is considered in the stationary reference frame. The rotating part of the computational domain includes also a human body model. Localized effects of carbon dioxide dispersion are examined. Strong influence of the rotating HPC equipment on the CO2 distribution detected is discussed.

  10. Genetic Programming Neural Networks: A Powerful Bioinformatics Tool for Human Genetics.

    Science.gov (United States)

    Ritchie, Marylyn D; Motsinger, Alison A; Bush, William S; Coffey, Christopher S; Moore, Jason H

    2007-01-01

    The identification of genes that influence the risk of common, complex disease primarily through interactions with other genes and environmental factors remains a statistical and computational challenge in genetic epidemiology. This challenge is partly due to the limitations of parametric statistical methods for detecting genetic effects that are dependent solely or partially on interactions. We have previously introduced a genetic programming neural network (GPNN) as a method for optimizing the architecture of a neural network to improve the identification of genetic and gene-environment combinations associated with disease risk. Previous empirical studies suggest GPNN has excellent power for identifying gene-gene and gene-environment interactions. The goal of this study was to compare the power of GPNN to stepwise logistic regression (SLR) and classification and regression trees (CART) for identifying gene-gene and gene-environment interactions. SLR and CART are standard methods of analysis for genetic association studies. Using simulated data, we show that GPNN has higher power to identify gene-gene and gene-environment interactions than SLR and CART. These results indicate that GPNN may be a useful pattern recognition approach for detecting gene-gene and gene-environment interactions in studies of human disease.

  11. Upper body contributions to power generation during rapid, overhand throwing in humans.

    Science.gov (United States)

    Roach, Neil T; Lieberman, Daniel E

    2014-06-15

    High-speed and accurate throwing is a distinctive human behavior. Achieving fast projectile speeds during throwing requires a combination of elastic energy storage at the shoulder, as well as the transfer of kinetic energy from proximal body segments to distal segments. However, the biomechanical bases of these mechanisms are not completely understood. We used inverse dynamics analyses of kinematic data from 20 baseball players fitted with four different braces that inhibit specific motions to test a model of power generation at key joints during the throwing motion. We found that most of the work produced during throwing is generated at the hips, and much of this work (combined with smaller contributions from the pectoralis major) is used to load elastic elements in the shoulder and power the rapid acceleration of the projectile. Despite rapid angular velocities at the elbow and wrist, the restrictions confirm that much of the power generated to produce these distal movements comes from larger proximal segments, such as the shoulder and torso. Wrist hyperextension enhances performance only modestly. Together, our data also suggest that heavy reliance on elastic energy storage may help explain some common throwing injuries and can provide further insight into the evolution of the upper body and when our ancestors first developed the ability to produce high-speed throws.

  12. Multiplicative processes and power laws in human reaction times derived from hyperbolic functions

    Energy Technology Data Exchange (ETDEWEB)

    Medina, José M., E-mail: jmanuel@fisica.uminho.pt [Center for Physics, University of Minho, Campus de Gualtar, 4710-057 Braga (Portugal)

    2012-04-09

    In sensory psychophysics reaction time is a measure of the stochastic latency elapsed from stimulus presentation until a sensory response occurs as soon as possible. A random multiplicative model of reaction time variability is investigated for generating the reaction time probability density functions. The model describes a generic class of hyperbolic functions by Piéron's law. The results demonstrate that reaction time distributions are the combination of log-normal with power law density functions. A transition from log-normal to power law behavior is found and depends on the transfer of information in neurons. The conditions to obtain Zipf's law are analyzed. -- Highlights: ► I have examined human reaction time variability by random multiplicative processes. ► A transition from power law to log-normal distributions is described. ► The transition depends on the transfer of information in neurons. ► Zipf's law in reaction time distributions depends on the exponent of Piéron's law.

  13. Modelled operation of the Shetlands Islands power system comparing computational and human operators` load forecasts

    Energy Technology Data Exchange (ETDEWEB)

    Hill, D.C. [University Coll. of North Wales, Menai Bridge (United Kingdom). School of Ocean Science; Infield, D.G. [Loughborough Univ. of Technology (United Kingdom). Dept. of Electronic and Electrical Engineering

    1995-11-01

    A load forecasting technique, based upon an autoregressive (AR) method is presented. Its use for short term load forecasting is assessed by direct comparison with real forecasts made by human operators of the Lerwick power station on the Shetland Islands. A substantial improvement in load prediction, as measured by a reduction of RMS error, is demonstrated. Shetland has a total installed capacity of about 68 MW, and an average load (1990) of around 20 MW. Although the operators could forecast the load for a few distinct hours better than the AR method, results from simulations of the scheduling and operation of the generating plant show that the AR forecasts provide increased overall system performance. A detailed model of the island power system, which includes plant scheduling, was run using the AR and Lerwick operators` forecasts as input to the scheduling routine. A reduction in plant cycling, underloading and fuel consumption was obtained using the AR forecasts rather than the operators` forecasts in simulations over a 28 day study period. It is concluded that the load forecasting method presented could be of benefit to the operators of such mesoscale power systems. (author)

  14. 微波功率GaAs MESFET小信号等效电路的研究%Research on the Small-Signal Equivalent Circuit Parameters of Microwave Power GaAs MESFET

    Institute of Scientific and Technical Information of China (English)

    顾聪; 刘佑宝

    2000-01-01

    Some improved methods for extracting small-signal equivalent circuit parametersare proposed in this paper. The methods include: determining all elements' sensitivities to the sum of error functions, optimization sequence and direction of objective functions, eigenvalues and eigenvectors of Hessian matrix and the approach of stabilizing algorithm. The calculated values well agree with the measurenent ones.%提出了计算功率GaAs MESFET小信号模型参数的一些改进方法,包括计算Hesse矩阵本征值和本征向量,确定各元件对总误差的敏感度、目标函数的优化顺序和优化方向,以及稳定的计算方法,计算结果与器件的测量值吻合。

  15. Morita Equivalence for Factorisable Semigroups

    Institute of Scientific and Technical Information of China (English)

    Yu Qun CHEN; K. P. SHUM

    2001-01-01

    Recall that the semigroups S and R are said to be strongly Morita equivalent if there exists a unitary Morita context (S,R,S PR,RQs, <, []) with < and [] surjective. For a factorisable semigroup S, we denote s = {(s1, s2) ∈ S× S | ss1 =ss2,s ∈ S}, S' = S/s and US-FAct= {sM ∈S- Act|SM = M and SHoms(S, M) ≌ M}. We show that, for factorisable semigroups S and R, the categories US-FAct and UR-FAct are equivalent if and only if the semigroups S' and R' are strongly Morita equivalent. Some conditions for a factorisable semigroup to be strongly Morita equivalent to a sandwich semigroup, local units semigroup, monoid and group separately are also given. Moreover, we show that a semigroup S is completely simple if and only if S is strongly Morita equivalent to a group and for any index set I, S SHoms(S,Ⅱi∈ S)→Ⅱi∈S, s t·f→(st)f is an S-isomorphism.

  16. Interpretation and power : a study of contemporary reformist trends in muslim societies andtheir relationship to UN standards of human rigths

    OpenAIRE

    Selahvarzi, Chrysostom

    2000-01-01

    This study focuses on the issues of politics and power in contemporary Muslim societies. It is a study of the reformist trends in contemporary Muslim societies, and Islam s relation with politics and human rights is viewed from this perspective. The starting point for the discussion in this paper is the fact that UN standards of human rights are violated by most of the governments of contemporary Muslim societies. Neither in theory, as manifested through the various Islamic schemes for human ...

  17. Updating Human Factors Engineering Guidelines for Conducting Safety Reviews of Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    O, J.M.; Higgins, J.; Stephen Fleger - NRC

    2011-09-19

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool. To this end, the NRC is updating its guidance to stay current with recent research on human performance, advances in HFE methods and tools, and new technology being employed in plant and control room design. This paper describes the role of HFE guidelines in the safety review process and the content of the key HFE guidelines used. Then we will present the methodology used to develop HFE guidance and update these documents, and describe the current status of the update program.

  18. Safe Operation of Nuclear Power Plants: Impacts of Human and Organisational Factors and Emerging Technologies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    In co-operation with the OECD Nuclear Energy Agency (NEA), the Halden Reactor Project organised a Summer School on ''Safe Operation of Nuclear Power Plants: Impacts of Human and Organisational Factors and Emerging Technologies'' in the period August 27-August 31, 2001. The Summer School was intended for scientists, engineers and technicians working for nuclear installations, engineering companies, industry and members of universities and research institutes, who wanted to broaden their nuclear background by getting acquainted with Man-Technology-Organisation-related subjects and issues. The Summer School should also serve to transfer knowledge to the ''young generation'' in the nuclear field. The following presentations were given: (1) Overview of the Nuclear Community and Current issues, (2) The Elements of Safety Culture; Evaluation of Events, (3) Quality Management (QM), (4) Probabilistic Risk Assessment (PSA), (5) Human Behaviour from the Viewpoint of Industrial Psychology, (6) Technical tour of the Halden Project Experimental Facilities, (7) Human Factors in Control Room Design, (8) Computerised Operator Support Systems (COSSs) and (9) Artificial Intelligence; a new Approach. Most of the contributions are overhead figures from spoken lectures.

  19. Energy Harvesting from the Animal/Human Body for Self-Powered Electronics.

    Science.gov (United States)

    Dagdeviren, Canan; Li, Zhou; Wang, Zhong Lin

    2017-06-21

    Living subjects (i.e., humans and animals) have abundant sources of energy in chemical, thermal, and mechanical forms. The use of these energies presents a viable way to overcome the battery capacity limitation that constrains the long-term operation of wearable/implantable devices. The intersection of novel materials and fabrication techniques offers boundless possibilities for the benefit of human health and well-being via various types of energy harvesters. This review summarizes the existing approaches that have been demonstrated to harvest energy from the bodies of living subjects for self-powered electronics. We present material choices, device layouts, and operation principles of these energy harvesters with a focus on in vivo applications. We discuss a broad range of energy harvesters placed in or on various body parts of human and animal models. We conclude with an outlook of future research in which the integration of various energy harvesters with advanced electronics can provide a new platform for the development of novel technologies for disease diagnostics, treatment, and prevention.

  20. Matching of equivalent field regions

    DEFF Research Database (Denmark)

    Appel-Hansen, Jørgen; Rengarajan, S.B.

    2005-01-01

    screen, having the same homogeneous medium on both sides and an impressed current on one aide, an alternative procedure is relevant. We make use of the fact that in the aperture the tangential component of the magnetic field due to the induced currents in the screen is zero. The use of such a procedure......In aperture problems, integral equations for equivalent currents are often found by enforcing matching of equivalent fields. The enforcement is made in the aperture surface region adjoining the two volumes on each side of the aperture. In the case of an aperture in a planar perfectly conducting...... shows that equivalent currents can be found by a consideration of only one of the two volumes into which the aperture plane divides the space. Furthermore, from a consideration of an automatic matching at the aperture, additional information about tangential as well as normal field components...

  1. Teleparallel Equivalent of Lovelock Gravity

    CERN Document Server

    Gonzalez, P A

    2015-01-01

    There is a growing interest in modified gravity theories based on torsion due to these theories prove to exhibit interesting cosmological implications. In this work, inspired by the teleparallel formulation of General Relativity we present its extension to Lovelock Gravity known as the most natural extension of general relativity in higher-dimensional spacetimes. First, we review Teleparallel Equivalent of General Relativity and Teleparallel Equivalent of Gauss-Bonnet Gravity, and then we construct Teleparallel Equivalent of Lovelock Gravity. In order to achieve this goal we use the vielbein and the connection, without imposing the Weitzenb\\"ock connection. Then, we extract the teleparallel formulation of the theory by setting the curvature to be null.

  2. Mathematically Equivalent, Computationally Non-equivalent Formulas and Software Comprehensibility

    Science.gov (United States)

    2016-06-07

    and Software Comprehensibility Marvin J. Goldstein Surface Ship Sonar Department Approved for public release; distribution unlimited Report...equivalent Formulas and Software Comprehensibility 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Marvin Goldstein...13. SUPPLEMENTARY NOTES NUWC2015 14. ABSTRACT In the development of mathematical software , often the formula that defines the mathematical purpose

  3. 特高压直流输电线路等效干扰电流的计算以及影响因素的研究%Computation of Equivalent Disturbing Current in UHVDC Power Transmission Lines and Analysis on Its Influencing Factors

    Institute of Scientific and Technical Information of China (English)

    赵鹏

    2012-01-01

    高压直流输电工程中,常以等效干扰电流作为限制直流谐波水平的标准.为了计算出准确的等效干扰电流,利用3脉动模型,对特高压直流输电工程进行了建模,计算了不同的直流滤波系统参数的等效干扰电流,得出了等效干扰电流随直流滤波系统中各部分参数变化的规律,即:等效干扰电流随平波电抗器电感值的增大而减小,随中性线接地电容的增大而减小,随直流滤波器高压电容值的增加而减小,并分别得出了变化规律曲线;文中还给出了使等效干扰电流满足允许值要求的滤波系统参数.%Equivalent disturbing current is used as the standard of restricting harmonic current level at DC side in HVDC project. To compute accurate equivalent disturbing current, using 3-pulse model the UHVDC power transmission project was modeled and equivalent disturbing currents under different parameters of DC filtering system were calculated, thus following rules of equivalent disturbing current varying with parameters of component parameters were attained: the equivalent disturbing current decreases with the increase of inductance value of smoothing reactor; it decreases with the increase of neutral-line-to ground capacitance; it decreases with the increase of capacity of HV capacitor of DC filter, and corresponding varying curves were obtained. Besides, the parameters of the filtering system, by which the equivalent disturbing current could meet the requirement of the allowable value, were proposed.

  4. Teleparallel equivalent of Lovelock gravity

    Science.gov (United States)

    González, P. A.; Vásquez, Yerko

    2015-12-01

    There is a growing interest in modified gravity theories based on torsion, as these theories exhibit interesting cosmological implications. In this work inspired by the teleparallel formulation of general relativity, we present its extension to Lovelock gravity known as the most natural extension of general relativity in higher-dimensional space-times. First, we review the teleparallel equivalent of general relativity and Gauss-Bonnet gravity, and then we construct the teleparallel equivalent of Lovelock gravity. In order to achieve this goal, we use the vielbein and the connection without imposing the Weitzenböck connection. Then, we extract the teleparallel formulation of the theory by setting the curvature to null.

  5. Risk assessment in the electric power transmission business: a proposal for equivalence between debenture bonds and share certificates; Avaliacao de risco no negocio de transmissao de energia eletrica: uma proposta de equivalencia entre debentures e acoes ordinarias

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, Paulo Glicio da [Companha Hidroeletrica do Sao Francisco (CHESF), Recife, PE (Brazil); Araujo, Juliana Vale [Banco Central do Brasil, Brasilia, DF (Brazil)

    2008-07-01

    Electric Energy Transmission Enterprises are significantly affected by the loan they borrow, because the debt service impacts the company's profit and its liquidity. Nowadays, the cheapest source of funds is the National Bank for Economic and Social Development - BNDES. In the other hand, companies from the electric energy sector have borrowed funds from securities issues, as debentures. The great advantage from issuing debentures is its flexibility in some features as interest rate, amortization period, amortization system, etc, that are chosen by the security issuer. The interest rate is an important factor, since it directly affects the project's result and its cash availability. However, which would be the ideal interest rate, considering the debentures' risk?. In this study, the stockholder and debtholder (debentures' holder) risks is measured using the ARCH models and the Monte Carlo Simulation Method. The shareholder's SI was applied to the debentures, assuming that the stocks and debentures should be the same Sharpe Index. It was attributed to the debentures the interest rate of 7% per year + IPCA and it was observed that to the debentures' SI be equivalent to the stock's SI, the return of the debtholder should be 12,12% per year + IPCA, because its risk (measured in this work) is superior to the shareholder's risk. (author)

  6. Indicators of Economic Progress: The Power of Measurement and Human Welfare

    Directory of Open Access Journals (Sweden)

    Garry Jacobs

    2010-10-01

    Full Text Available Right measurement is a powerful instrument for social progress; wrong or imprecise measurement a source of hazard and even havoc. The essential purpose of economic activity is the promotion of human development, welfare and well-being in a sustainable manner, and not growth for growth’s sake, yet we lack effective measures to monitor progress toward these objectives. Advances in understanding, theory and measurement must necessarily proceed hand in hand. A companion article in this publication sets forth the urgent need for new theory in economics. This article sets forth the complementary need for new measures. The stakes are high and the choice is ours. On one side, rising social tensions, recurring financial crises and ecological disaster; on the other, the progressive unfolding and development of human capacity in harmony with Nature. The deficiencies of GDP as a measure are well-documented by leading economists Kuznets, Tobin, Tinbergen and many others; but, unfortunately, decision-making still remains largely based on GDP, valid during 1930-70 perhaps, but certainly inappropriate today. The challenge is to derive more appropriate indicators to reflect real, sustainable economic welfare, social development and human wellbeing. The attributes that have made GDP so successful are often overlooked — it provides clear objectives for policy and decision-making. We propose new composite indicator, HEWI, which can be used to guide decision-making, which retains the strengths associated with GDP, while substantially enhancing its value as a measure of human economic development. HEWI monitors progress on factors that contribute prominently to present economic welfare — household consumption, government welfare-related expenditure, income inequality and unemployment — as well as factors that have the potential to significantly enhance long term sustainability — education, fossil fuel energy efficiency and net household savings. The index

  7. A code for simulation of human failure events in nuclear power plants: SIMPROC

    Energy Technology Data Exchange (ETDEWEB)

    Gil, Jesus, E-mail: jesus.gil@indizen.co [Indizen Technologies S.L., Pablo Iglesias 2-3 oB-2, 28003 Madrid (Spain); Fernandez, Ivan, E-mail: ivan.fernandez@indizen.co [Indizen Technologies S.L., Pablo Iglesias 2-3 oB-2, 28003 Madrid (Spain); Murcia, Santiago, E-mail: santiago.murcia@indizen.co [Indizen Technologies S.L., Pablo Iglesias 2-3 oB-2, 28003 Madrid (Spain); Gomez, Javier, E-mail: javier.mundina@indizen.co [Indizen Technologies S.L., Pablo Iglesias 2-3 oB-2, 28003 Madrid (Spain); Marrao, Hugo, E-mail: hmarrao@indizen.co [Indizen Technologies S.L., Pablo Iglesias 2-3 oB-2, 28003 Madrid (Spain); Queral, Cesar, E-mail: cesar.queral@upm.e [ETSI Minas - Universidad Politecnica de Madrid, Alenza 4, 28003 Madrid (Spain); Exposito, Antonio, E-mail: antonio.exposito@upm.e [ETSI Minas - Universidad Politecnica de Madrid, Alenza 4, 28003 Madrid (Spain); Rodriguez, Gabriel, E-mail: gabriel.rodriguez.martin@upm.e [ETSI Minas - Universidad Politecnica de Madrid, Alenza 4, 28003 Madrid (Spain); Ibanez, Luisa, E-mail: luisa.ibanez@upm.e [ETSI Minas - Universidad Politecnica de Madrid, Alenza 4, 28003 Madrid (Spain); Hortal, Javier, E-mail: fjhr@csn.e [Consejo de Seguridad Nuclear, Justo Dorado 11, 28040 Madrid (Spain); Izquierdo, Jose M., E-mail: jmir@csn.e [Consejo de Seguridad Nuclear, Justo Dorado 11, 28040 Madrid (Spain); Sanchez, Miguel, E-mail: msp@csn.e [Consejo de Seguridad Nuclear, Justo Dorado 11, 28040 Madrid (Spain); Melendez, Enrique, E-mail: ema@csn.e [Consejo de Seguridad Nuclear, Justo Dorado 11, 28040 Madrid (Spain)

    2011-04-15

    Over the past years, many Nuclear Power Plant organizations have performed Probabilistic Safety Assessments to identify and understand key plant vulnerabilities. As part of enhancing the PSA quality, the Human Reliability Analysis is essential to make a realistic evaluation of safety and about the potential facility's weaknesses. Moreover, it has to be noted that HRA continues to be a large source of uncertainty in the PSAs. Within their current joint collaborative activities, Indizen, Universidad Politecnica de Madrid and Consejo de Seguridad Nuclear have developed the so-called SIMulator of PROCedures (SIMPROC), a tool aiming at simulate events related with human actions and able to interact with a plant simulation model. The tool helps the analyst to quantify the importance of human actions in the final plant state. Among others, the main goal of SIMPROC is to check the Emergency Operating Procedures being used by operating crew in order to lead the plant to a safe shutdown plant state. Currently SIMPROC is coupled with the SCAIS software package, but the tool is flexible enough to be linked to other plant simulation codes. SIMPROC-SCAIS applications are shown in the present article to illustrate the tool performance. The applications were developed in the framework of the Nuclear Energy Agency project on Safety Margin Assessment and Applications (SM2A). First an introductory example was performed to obtain the damage domain boundary of a selected sequence from a SBLOCA. Secondly, the damage domain area of a selected sequence from a loss of Component Cooling Water with a subsequent seal LOCA was calculated. SIMPROC simulates the corresponding human actions in both cases. The results achieved shown how the system can be adapted to a wide range of purposes such as Dynamic Event Tree delineation, Emergency Operating Procedures and damage domain search.

  8. Applying Human Factors Evaluation and Design Guidance to a Nuclear Power Plant Digital Control System

    Energy Technology Data Exchange (ETDEWEB)

    Thomas Ulrich; Ronald Boring; William Phoenix; Emily Dehority; Tim Whiting; Jonathan Morrell; Rhett Backstrom

    2012-08-01

    The United States (U.S.) nuclear industry, like similar process control industries, has moved toward upgrading its control rooms. The upgraded control rooms typically feature digital control system (DCS) displays embedded in the panels. These displays gather information from the system and represent that information on a single display surface. In this manner, the DCS combines many previously separate analog indicators and controls into a single digital display, whereby the operators can toggle between multiple windows to monitor and control different aspects of the plant. The design of the DCS depends on the function of the system it monitors, but revolves around presenting the information most germane to an operator at any point in time. DCSs require a carefully designed human system interface. This report centers on redesigning existing DCS displays for an example chemical volume control system (CVCS) at a U.S. nuclear power plant. The crucial nature of the CVCS, which controls coolant levels and boration in the primary system, requires a thorough human factors evaluation of its supporting DCS. The initial digital controls being developed for the DCSs tend to directly mimic the former analog controls. There are, however, unique operator interactions with a digital vs. analog interface, and the differences have not always been carefully factored in the translation of an analog interface to a replacement DCS. To ensure safety, efficiency, and usability of the emerging DCSs, a human factors usability evaluation was conducted on a CVCS DCS currently being used and refined at an existing U.S. nuclear power plant. Subject matter experts from process control engineering, software development, and human factors evaluated the DCS displays to document potential usability issues and propose design recommendations. The evaluation yielded 167 potential usability issues with the DCS. These issues should not be considered operator performance problems but rather opportunities

  9. Human resource accounting in electric power enterprises%浅谈电力企业的人力资源会计

    Institute of Scientific and Technical Information of China (English)

    梁红燕

    2013-01-01

    The power industry is knowledge intensive and technology intensive enterprises,along with the electric power enterprise reform,electric power enterprise human resources management focus has changed from the original personnel,labor management to human resource capital operation management mode.In the new situation,how to build the management system of human resource accounting, human resources to maximize the role of enterprise development,is the new requirement of modern electric power enterprise based on human resource management, and constantly promote the major move of landing the power of corporate strategy.%电力企业是知识密集型和技术密集型的企业,随着电力企业改革的不断深入,电力企业人力资源管理的重心已由原来的人事、劳资管理转化为人力资源资本化运作的管理模式。在新形势下,如何构建人力资源会计管理体系,最大限度发挥人力资源对企业发展的支撑作用,是现代电力企业对人力资源管理提出的新要求,也是不断促进电力企业战略落地的重大举措。

  10. Origins of power-law degree distribution in the heterogeneity of human activity in social networks

    CERN Document Server

    Muchnik, Lev; Parra, Lucas C; Reis, Saulo D S; Andrade,, Jose S; Havlin, Shlomo; Makse, Hernan A

    2013-01-01

    The probability distribution of number of ties of an individual in a social network follows a scale-free power-law. However, how this distribution arises has not been conclusively demonstrated in direct analyses of people's actions in social networks. Here, we perform a causal inference analysis and find an underlying cause for this phenomenon. Our analysis indicates that heavy-tailed degree distribution is causally determined by similarly skewed distribution of human activity. Specifically, the degree of an individual is entirely random - following a "maximum entropy attachment" model - except for its mean value which depends deterministically on the volume of the users' activity. This relation cannot be explained by interactive models, like preferential attachment, since the observed actions are not likely to be caused by interactions with other people.

  11. Effect of low-power red light laser irradiation on the viability of human skin fibroblast

    Energy Technology Data Exchange (ETDEWEB)

    Bednarska, K.; Rozga, B.; Leyko, W.; Bryszewska, M. [Institute of Biophysics, University of Lodz (Poland); Kolodziejczyk, K.; Szosland, D. [Diabetological Clinic, Medical Academy of Lodz (Poland)

    1998-10-01

    Human skin fibroblast monolayers (S-126 cell line) were exposed to laser radiation (wavelength 670 nm, power density 40 mW/cm{sup 2}). The energy densities were 2 J/cm{sup 2} and 12 J/cm{sup 2}, respectively, and the irradiation was carried out at a temperature of 22 C. For fibroblast viability evaluation, the colorimetric assay (conversion of thiazolyl blue to formazan) was used. The experiments were carried out at 37 C, in the presence of 5% CO{sub 2}, and at different time periods of incubation after irradiation (2, 4, 8 h and 1, 2, 3, 4, 5 days). The results indicated that there was a certain stimulating effect on the long-term proliferation of skin fibroblasts and that the stimulation proceeded in two stages, the first one 2 h and the second one 3 days post-irradiation. (orig.) With 4 figs., 2 tabs., 13 refs.

  12. Human Gait Feature Extraction Including a Kinematic Analysis Toward Robotic Power Assistance

    Directory of Open Access Journals (Sweden)

    Mario I. Chacon-Murguia

    2012-09-01

    Full Text Available The present work proposes a method for human gait and kinematic analysis. Gait analysis consists of the determination of hip, knee and ankle positions through video analysis. Gait kinematic for the thigh and knee is then generated from this data. Evaluations of the gait analysis method indicate an acceptable performance of 86.66% for hip and knee position estimation, and comparable findings with other reported works for gait kinematic. A coordinate systems assignment is performed according to the DH algorithm and a direct kinematic model of the legs is obtained. The legs’ angles obtained from the video analysis are applied to the kinematic model in order to revise the application of this model to robotic legs in a power assisted system.

  13. A BRIEF HISTORY OF HUMAN POWERED FLIGHT: FROM PHYSIOLOGY TO PHILOSOPHY

    Directory of Open Access Journals (Sweden)

    Pietro Enrico di Prampero

    2010-01-01

    Full Text Available The development of a scientific theory (T can be separated into successive phases: i Fantasy, to conceive T ii Analysis to couch T into formal language iii Action, to apply in practice the predictions of T. The history of human powered flight, in which case the three phases are stretched over several thousand years, allow us to better appreciate their intrinsic characteristics. Fantasy, dating back to the myth of Ikarus, must be experimentally testable, as indeed were Daedalus’ wings. Analysis must state in quantitative terms the laws governing the matter at stake. Action, from Leonardo’s unsuccessful attempts to the crossings of the British Channel in 1979 and of the arm of the sea separating Crete from mainland Greece in 1988, has the aim of shaping the world according to our will. The kernel of any “proper” T is a formal system wherein a set of operational rules allows us to manipulate a set of symbols, representing the objects of T, on the bases of a limited number of axioms. In such formal systems, “theorem” is a string of symbols that can be arrived at in a finite number of steps from the axioms, applying the canonical operational rules. However, as Kurt Gödel showed in 1931, it is possible to demonstrate that, within a sufficiently powerful formal system, there exists demonstrably true strings of symbols that are not theorems. Thus, even in an ultra-powerful theory of everything, there will still be truths that can not be arrived at within the theory.

  14. The effect of precision and power grips on activations in human auditory cortex

    Directory of Open Access Journals (Sweden)

    Patrik Alexander Wikman

    2015-10-01

    Full Text Available The neuroanatomical pathways interconnecting auditory and motor cortices play a key role in current models of human auditory cortex (AC. Evidently, auditory-motor interaction is important in speech and music production, but the significance of these cortical pathways in other auditory processing is not well known. We investigated the general effects of motor responding on AC activations to sounds during auditory and visual tasks. During all task blocks, subjects detected targets in the designated modality, reported the relative number of targets at the end of the block, and ignored the stimuli presented in the opposite modality. In each block, they were also instructed to respond to targets either using a precision grip, power grip, or to give no overt target responses. We found that motor responding strongly modulated AC activations. First, during both visual and auditory tasks, activations in widespread regions of AC decreased when subjects made precision and power grip responses to targets. Second, activations in AC were modulated by grip type during the auditory but not during the visual task. Further, the motor effects were distinct from the strong attention-related modulations in AC. These results are consistent with the idea that operations in AC are shaped by its connections with motor cortical regions.

  15. Design of a compact low-power human-computer interaction equipment for hand motion

    Science.gov (United States)

    Wu, Xianwei; Jin, Wenguang

    2017-01-01

    Human-Computer Interaction (HCI) raises demand of convenience, endurance, responsiveness and naturalness. This paper describes a design of a compact wearable low-power HCI equipment applied to gesture recognition. System combines multi-mode sense signals: the vision sense signal and the motion sense signal, and the equipment is equipped with the depth camera and the motion sensor. The dimension (40 mm × 30 mm) and structure is compact and portable after tight integration. System is built on a module layered framework, which contributes to real-time collection (60 fps), process and transmission via synchronous confusion with asynchronous concurrent collection and wireless Blue 4.0 transmission. To minimize equipment's energy consumption, system makes use of low-power components, managing peripheral state dynamically, switching into idle mode intelligently, pulse-width modulation (PWM) of the NIR LEDs of the depth camera and algorithm optimization by the motion sensor. To test this equipment's function and performance, a gesture recognition algorithm is applied to system. As the result presents, general energy consumption could be as low as 0.5 W.

  16. Power-Frequency Magnetic Field Inhibits Adipogenic Differentiation in Human ADSC

    Directory of Open Access Journals (Sweden)

    María Antonia Martínez

    2015-12-01

    Full Text Available Background/Aims: Semicircular lipoatrophy (SL is an idiopathic condition characterized by atrophy of subcutaneous fatty tissue. Although several studies have suggested a possible association between SL and occupational exposure to power frequency magnetic fields (MF, no mechanism has been proposed so far that explains an influence of these fields on adipogenesis. Methods: The study investigates the effects of a 50 Hz, 100 µT MF on the adipogenesis of stem cells isolated from human adipose tissue (ADSC. Cells were plated in Petri dishes and either exposed intermittently to the field for 42 hours or sham-exposed. Results: Field exposure significantly reduced lipid accumulation within the cells, revealed in Oil Red O stained samples by spectrophotometry and colorimetry. Early cell passages were particularly sensitive to the effect: 30.40 ± 5.77% and 47.96 ± 12.47% below controls in the spectrophotometric and colorimetric assays, respectively. Such antiadipogenic effect was accompanied by significant changes in the expression of key effectors/regulators of early adipogenesis: PPARγ, p-ERK1/2 and Sox9, indicating that at least the ERK/PPARγ signaling pathway could be involved in the effect. Conclusions: These results constitute an experimental support to the hypothesis that power frequency MF can be one of the factors involved in the etiology of SL.

  17. CFD Ventilation Study for the Human Powered Centrifuge at the International Space Station

    Science.gov (United States)

    Son, Chang H.

    2011-01-01

    The Human Powered Centrifuge (HPC) is a hyper gravity facility that will be installed on board the International Space Station (ISS) to enable crew exercises under the artificial gravity conditions. The HPC equipment includes a bicycle for long-term exercises of a crewmember that provides power for rotation of HPC at a speed of 30 rpm. The crewmember exercising vigorously on the centrifuge generates the amount of carbon dioxide of several times higher than a crewmember in ordinary conditions. The goal of the study is to analyze the airflow and carbon dioxide distribution within Pressurized Multipurpose Module (PMM) cabin. The 3D computational model included PMM cabin. The full unsteady formulation was used for airflow and CO2 transport modeling with the so-called sliding mesh concept is considered in the rotating reference frame while the rest of the cabin volume is considered in the stationary reference frame. The localized effects of carbon dioxide dispersion are examined. Strong influence of the rotating HPC equipment on the CO2 distribution is detected and discussed.

  18. European Equivalencies in Legal Interpreting and Translation

    DEFF Research Database (Denmark)

    Corsellis, Ann; Hertog, Erik; Martinsen, Bodil

    2002-01-01

    Within Europe there is increasing freedom of movement between countries and increasing inward migration. As a result, equivalent standards of legl interpreting and translation are required to allow reliable communication for judicial cooperation between member states, for criminal and civil matters...... which cross national borders and for the needs of multilingual populations. The European Convention of Human Rights (article 6, paragrph 3) is one of the main planks of relevant legislation. This international, two year project has been funded by the EU Grotius programme to set out what is required...

  19. Acquired Equivalence Changes Stimulus Representations

    Science.gov (United States)

    Meeter, M.; Shohamy, D.; Myers, C. E.

    2009-01-01

    Acquired equivalence is a paradigm in which generalization is increased between two superficially dissimilar stimuli (or antecedents) that have previously been associated with similar outcomes (or consequents). Several possible mechanisms have been proposed, including changes in stimulus representations, either in the form of added associations or…

  20. USEPA PATHOGEN EQUIVALENCY COMMITTEE RETREAT

    Science.gov (United States)

    The Pathogen Equivalency Committee held its retreat from September 20-21, 2005 at Hueston Woods State Park in College Corner, Ohio. This presentation will update the PEC’s membership on emerging pathogens, analytical methods, disinfection techniques, risk analysis, preparat...

  1. Comments on field equivalence principles

    DEFF Research Database (Denmark)

    Appel-Hansen, Jørgen

    1987-01-01

    It is pointed Out that often-used arguments based on a short-circuit concept in presentations of field equivalence principles are not correct. An alternative presentation based on the uniqueness theorem is given. It does not contradict the results obtained by using the short-circuit concept...

  2. A study on the human reliability analysis in probabilistic safety assessment during low power/shutdown operation of nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Kang, D. I.; Sung, T. Y.; Jung, W. D.; Yang, J. E.; Park, J. H.; Lee, Y. H.; Hwang, M. J.; Kim, K. Y.; Jin, Y. H

    1997-02-01

    This report describes the review results of human reliability analysis (HRA) in the probabilistic safety assessment (PSA) during low power/shutdown operation of nuclear power plants (NPPs). We select four NPP PSA reports to review. These are System 80+ using THERP, Surry using SLIM, Grand Gulf using ASEP, Electric de France using simulator experiments. This report also describe the method, the procedure, the quantification example, the critical review and the insights of HRA which were used in the process of PSA of NPPs mentioned above. It is expected that this study results will be effectively used in HRA of domestic PSA during low power/shutdown operation of NPPs. (author). 18 refs., 1 tab.

  3. Theoretical assessment of the maximum obtainable power in wireless power transfer constrained by human body exposure limits in a typical room scenario.

    Science.gov (United States)

    Chen, Xi Lin; De Santis, Valerio; Umenei, Aghuinyue Esai

    2014-07-07

    In this study, the maximum received power obtainable through wireless power transfer (WPT) by a small receiver (Rx) coil from a relatively large transmitter (Tx) coil is numerically estimated in the frequency range from 100 kHz to 10 MHz based on human body exposure limits. Analytical calculations were first conducted to determine the worst-case coupling between a homogeneous cylindrical phantom with a radius of 0.65 m and a Tx coil positioned 0.1 m away with the radius ranging from 0.25 to 2.5 m. Subsequently, three high-resolution anatomical models were employed to compute the peak induced field intensities with respect to various Tx coil locations and dimensions. Based on the computational results, scaling factors which correlate the cylindrical phantom and anatomical model results were derived. Next, the optimal operating frequency, at which the highest transmitter source power can be utilized without exceeding the exposure limits, is found to be around 2 MHz. Finally, a formulation is proposed to estimate the maximum obtainable power of WPT in a typical room scenario while adhering to the human body exposure compliance mandates.

  4. Matching Derived Functionally-Same Stimulus Relations: Equivalence-Equivalence and Classical Analogies

    National Research Council Canada - National Science Library

    Carpentier, Franck; Smeets, Paul M; Barnes-Holmes, Dermot; Stewart, Ian

    2004-01-01

    ... (equivalence-equivalence). Similar performances are required in classical analogies (a : b :: c : d). Therefore, some researchers have argued that equivalence-equivalence can serve as a behavior analytic model for analogical reasoning...

  5. EQUIVALENCE VERSUS NON-EQUIVALENCE IN ECONOMIC TRANSLATION

    Directory of Open Access Journals (Sweden)

    Cristina, Chifane

    2012-01-01

    Full Text Available This paper aims at highlighting the fact that “equivalence” represents a concept worth revisiting and detailing upon when tackling the translation process of economic texts both from English into Romanian and from Romanian into English. Far from being exhaustive, our analysis will focus upon the problems arising from the lack of equivalence at the word level. Consequently, relevant examples from the economic field will be provided to account for the following types of non-equivalence at word level: culturespecific concepts; the source language concept is not lexicalised in the target language; the source language word is semantically complex; differences in physical and interpersonal perspective; differences in expressive meaning; differences in form; differences in frequency and purpose of using specific forms and the use of loan words in the source text. Likewise, we shall illustrate a number of translation strategies necessary to deal with the afore-mentioned cases of non-equivalence: translation by a more general word (superordinate; translation by a more neutral/less expressive word; translation by cultural substitution; translation using a loan word or loan word plus explanation; translation by paraphrase using a related word; translation by paraphrase using unrelated words; translation by omission and translation by illustration.

  6. The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34+ stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin

    OpenAIRE

    Proietto, AI; Mittag, D; Roberts, AW; Sprigg, N; L. Wu

    2012-01-01

    Dendritic cells (DCs) are immune cells specialized to capture, process and present antigen to T cells in order to initiate an appropriate adaptive immune response. The study of mouse DC has revealed a heterogeneous population of cells that differ in their development, surface phenotype and function. The study of human blood and spleen has shown the presence of two subsets of conventional DC including the CD1b/c+ and CD141+CLEC9A+ conventional DC (cDC) and a plasmacytoid DC (pDC) that is CD304...

  7. Calorimetric measurement and modelling of the equivalent series of capacitors

    Science.gov (United States)

    Seguin, B.; Gosse, J. P.; Ferrieux, J. P.

    1999-12-01

    The equivalent series resistance of polypropylene capacitors has been determined under rated voltage, in the range 1 kHz 1 MHz, between 220 K and 370 K by a calorimetric technique. The original feature of this determination of capacitor losses lies in the use of the isothermal calorimetry and in the measurement of an electrical power and not of a temperature increase. The frequency dependence of the equivalent series resistance, at various temperatures, enables to separate the losses in the conducting material from those in the dielectric and to get their respective variations as a function of frequency and temperature. These variations of the equivalent series resistance with frequency at a given temperature have been reproduced by using an equivalent circuit composed of resistors, inductors and capacitors. This model has been verified for non-sinusoidal waveforms such as those met with in a filtering circuit and is used to evaluate by simulation the losses of the capacitor.

  8. Design of Charge Sensitive Pre-amplifier for Tissue-equivalent Proportional Counter

    Institute of Scientific and Technical Information of China (English)

    NI; Ning; ZHANG; Wei-hua; XIAO; Xue-fu; GAO; Fei; SONG; Ming-zhe; HOU; Jin-bing; WANG; Hong-yu

    2015-01-01

    Tissue equivalent proportional counter(TEPC)can differentiate the dose equivalent contributed from neutron and gamma ray in a mixture field and measure absorb dose and dose equivalent in the cell of human,and it is more suitable than other measurement methods to evaluate the radiation effect.It is providing a reference

  9. 42 CFR 440.335 - Benchmark-equivalent health benefits coverage.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Benchmark-equivalent health benefits coverage. 440... HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS SERVICES: GENERAL PROVISIONS Benchmark Benefit and Benchmark-Equivalent Coverage § 440.335 Benchmark-equivalent health benefits coverage....

  10. Equivalence problem for Bishop surfaces

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The paper has two parts. We first briefly survey recent studies on the equivalence problem for real submanifolds in a complex space under the action of biholomorphic transformations. We will mainly focus on some of the recent studies of Bishop surfaces, which, in particular, includes the work of the authors. In the second part of the paper, we apply the general theory developed by the authors to explicitly classify an algebraic family of Bishop surfaces with a vanishing Bishop invariant. More precisely, we let M be a real submanifold of C 2 defined by an equation of the form w = zz + 2Re(z s + az s+1 ) with s≥ 3 and a a complex parameter. We will prove in the second part of the paper that for s≥ 4 two such surfaces are holomorphically equivalent if and only if the parameter differs by a certain rotation. When s = 3, we show that surfaces of this type with two different real parameters are not holomorphically equivalent.

  11. Equivalent statistics and data interpretation.

    Science.gov (United States)

    Francis, Gregory

    2016-10-14

    Recent reform efforts in psychological science have led to a plethora of choices for scientists to analyze their data. A scientist making an inference about their data must now decide whether to report a p value, summarize the data with a standardized effect size and its confidence interval, report a Bayes Factor, or use other model comparison methods. To make good choices among these options, it is necessary for researchers to understand the characteristics of the various statistics used by the different analysis frameworks. Toward that end, this paper makes two contributions. First, it shows that for the case of a two-sample t test with known sample sizes, many different summary statistics are mathematically equivalent in the sense that they are based on the very same information in the data set. When the sample sizes are known, the p value provides as much information about a data set as the confidence interval of Cohen's d or a JZS Bayes factor. Second, this equivalence means that different analysis methods differ only in their interpretation of the empirical data. At first glance, it might seem that mathematical equivalence of the statistics suggests that it does not matter much which statistic is reported, but the opposite is true because the appropriateness of a reported statistic is relative to the inference it promotes. Accordingly, scientists should choose an analysis method appropriate for their scientific investigation. A direct comparison of the different inferential frameworks provides some guidance for scientists to make good choices and improve scientific practice.

  12. 21 CFR 26.9 - Equivalence determination.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Equivalence determination. 26.9 Section 26.9 Food... Specific Sector Provisions for Pharmaceutical Good Manufacturing Practices § 26.9 Equivalence determination... document insufficient evidence of equivalence, lack of opportunity to assess equivalence or a determination...

  13. A Review on Level of Specific Absorption Rate Due to High Power Transmission Lines: Analysis toward Human Position Posture

    Directory of Open Access Journals (Sweden)

    Ghazali Z.

    2016-01-01

    Full Text Available The main contribution of this project is the development of a homogeneous model of a man to presents the specific absorption rate (SAR due to high power transmission line. As a low frequency application under high power transmission line of 50 Hz in electrical engineering, to studies the influence of human’s posture on specific absorption rate. This project designs two types of human body which one design uses most cylinder block and another design use brick block where both blocks have a different value of mesh cells. For each design has four types of posture are standing, sitting, arms up and arms out by using Computer Simulation Technology (CST Studio Software. This analysis does toward for four types of the human position postures because each posture has different value of specific absorption rate (SAR based on the size of the mesh cells of the design. Based on two designs of the human body, the lowest of the mesh cells value will reduce time to simulate SAR. For each posture has different value of SAR for each part of the human body because the whole human body has different types of tissues. Therefore, the CST studio software uses extremely to simulate the SAR value toward human position posture due to high power transmission line.

  14. Harnessing the power of conversations with virtual humans to change health behaviors.

    Science.gov (United States)

    Albright, Glenn; Adam, Cyrille; Serri, Deborah; Bleeker, Seth; Goldman, Ron

    2016-01-01

    Skillful, collaborative conversations are powerful tools to improve physical and mental health. Whether you are a parent talking with your child about the dangers of substance abuse, an educator concerned about a student's signs of psychological distress, a veteran worried about a buddy who is contemplating suicide, or a healthcare professional wanting to better engage patients to increase treatment compliance, having the skill, confidence and motivation to engage in conversations can truly transform the health and well-being of those you interact with. Kognito develops role-play simulations that prepare individuals to effectively lead real-life conversations that measurably improve social, emotional, and physical health. The behavior change model that drives the simulations draws upon components of game mechanics, virtual human simulation technology and integrates evidence-based instructional design components as well as principles of social-cognitive theory and neuroscience such as motivational interviewing, emotional regulation, empathy and mindfulness. In the simulations, users or enter a risk-free practice environment and engage in a conversation with intelligent, fully animated, and emotionally responsive virtual characters that model human behavior. It is in practicing these conversations, and receiving feedback from a virtual coach, that users learn to better lead conversations in real life. Numerous longitudinal studies have shown that users who complete Kognito simulations demonstrate statistically significant and sustained increases in attitudinal variables that predict behavior change including preparedness, likelihood, and self-efficacy to better manage conversations. Pending the target population, each online or mobile simulation resulted in desired behavior changes ranging from increased referrals of students, patients or veterans in psychological distress to mental health support services, or increasing physician patient-centered communication or

  15. Harnessing the power of conversations with virtual humans to change health behaviors

    Science.gov (United States)

    Adam, Cyrille; Serri, Deborah; Bleeker, Seth; Goldman, Ron

    2016-01-01

    Skillful, collaborative conversations are powerful tools to improve physical and mental health. Whether you are a parent talking with your child about the dangers of substance abuse, an educator concerned about a student’s signs of psychological distress, a veteran worried about a buddy who is contemplating suicide, or a healthcare professional wanting to better engage patients to increase treatment compliance, having the skill, confidence and motivation to engage in conversations can truly transform the health and well-being of those you interact with. Kognito develops role-play simulations that prepare individuals to effectively lead real-life conversations that measurably improve social, emotional, and physical health. The behavior change model that drives the simulations draws upon components of game mechanics, virtual human simulation technology and integrates evidence-based instructional design components as well as principles of social-cognitive theory and neuroscience such as motivational interviewing, emotional regulation, empathy and mindfulness. In the simulations, users or enter a risk-free practice environment and engage in a conversation with intelligent, fully animated, and emotionally responsive virtual characters that model human behavior. It is in practicing these conversations, and receiving feedback from a virtual coach, that users learn to better lead conversations in real life. Numerous longitudinal studies have shown that users who complete Kognito simulations demonstrate statistically significant and sustained increases in attitudinal variables that predict behavior change including preparedness, likelihood, and self-efficacy to better manage conversations. Pending the target population, each online or mobile simulation resulted in desired behavior changes ranging from increased referrals of students, patients or veterans in psychological distress to mental health support services, or increasing physician patient-centered communication or

  16. On the Translation Equivalence of Literature Works

    Institute of Scientific and Technical Information of China (English)

    吴娟

    2013-01-01

    As for translation principle, people have different opinions. The principle of equivalent translation may be is one of the most reason-able ones in today's translation world in my eyes. This paper focuses on the possibility and thec ondition to be achieved the biggest equivalence of the semantic, pragmatic and culture in order to get the conclusion that the translation equivalence is the proper principle. Besides,this paper has also discussed the pragmatic equivalence and cultural equivalence.

  17. On the Translation Equivalence of Literature Works

    Institute of Scientific and Technical Information of China (English)

    吴娟

    2013-01-01

    As for translation principle,people have different opinions.The principle of equivalent translation maybe is one of the most reasonable ones in today’s translation world in my eyes.This paper focuses on the possibility and the condition to be achieved the biggest equivalence of the semantic,pragmatic and culture in order to get the conclusion that the translation equivalence is the proper principle.Besides,this paper has also discussed the pragmatic equivalence and cultural equivalence.

  18. On an equivalence of fuzzy subgroups III

    Directory of Open Access Journals (Sweden)

    V. Murali

    2003-01-01

    Full Text Available This paper is the third in a series of papers studying equivalence classes of fuzzy subgroups of a given group under a suitable equivalence relation. We introduce the notion of a pinned flag in order to study the operations sum, intersection and union, and their behavior with respect to the equivalence. Further, we investigate the extent to which a homomorphism preserves the equivalence. Whenever the equivalences are not preserved, we have provided suitable counterexamples.

  19. Comparative study of the impacts of hydroelectric power plants with impacts avoided by a Virtual Plants Equivalents (VPEs) through of energy efficiency actions; Estudo comparativo dos impactos das usinas hidreletricas com os impactos evitados por uma usina virtual equivalente atraves das acoes de eficiencia energetica

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Roberto Perillo Barbosa da; Barros, Regiane Silva de [Universidade Estadual de Campinas (FEM/UNICAMP), SP (Brazil). Fac. de Engenharia Mecanica], emails: rpbsilva@fem.unicamp.br, rsbarros@fem.unicamp.br Rossi, Luiz Antonio [Universidade Estadual de Campinas (FEAGRI/UNICAMP), SP (Brazil). Fac. Engenharia Agricola], email: rossi@feagri.unicamp.br

    2010-07-01

    This article presents a comparative study of the impacts caused by Hydroelectric Power Plants (HPPs) in relation to the impacts avoided through actions that promotes energy efficiency called Virtual Plants Equivalents (VPEs). To do so, it was considering the recent results presented by the National Program for Electric Energy Conservation (PROCEL) to the year 2008, which shows that the program actions' in this period resulted in a Virtual Plant Equivalent of 1049 MW. It was performed a survey of the values of wetland and families displaced by the construction of hydropower plants and, later, it was compared these data with the values found in the literature and, finally, it was established that the actions of energy efficiency are important instruments to avoid (or at least postpone) the social and environmental impacts directly and indirectly that affects the whole society. Thus, it is suggested that there is a stimulus in relation to energy efficiency actions, what is observed nowadays in Brazil is that these actions are negligible before the potential that exists at industrial, commercial and residential sectors. (author)

  20. Antioxidant properties of modified rutin esters by DPPH, reducing power, iron chelation and human low density lipoprotein assays

    DEFF Research Database (Denmark)

    Lue, Bena-Marie; Nielsen, Nina Skall; Jacobsen, Charlotte;

    2010-01-01

    rutin compounds exhibited decreased reducing power and metal chelating abilities as compared to rutin. Conversely, investigations on the oxidation of human low density lipoprotein (LDL) revealed that rutin laurate was most effective in inhibiting oxidation by prolonging LDL lag time for an in vitro...

  1. Microencapsulation technology: a powerful tool for integrating expansion and cryopreservation of human embryonic stem cells.

    Science.gov (United States)

    Serra, Margarida; Correia, Cláudia; Malpique, Rita; Brito, Catarina; Jensen, Janne; Bjorquist, Petter; Carrondo, Manuel J T; Alves, Paula M

    2011-01-01

    The successful implementation of human embryonic stem cells (hESCs)-based technologies requires the production of relevant numbers of well-characterized cells and their efficient long-term storage. In this study, cells were microencapsulated in alginate to develop an integrated bioprocess for expansion and cryopreservation of pluripotent hESCs. Different three-dimensional (3D) culture strategies were evaluated and compared, specifically, microencapsulation of hESCs as: i) single cells, ii) aggregates and iii) immobilized on microcarriers. In order to establish a scalable bioprocess, hESC-microcapsules were cultured in stirred tank bioreactors.The combination of microencapsulation and microcarrier technology resulted in a highly efficient protocol for the production and storage of pluripotent hESCs. This strategy ensured high expansion ratios (an approximately twenty-fold increase in cell concentration) and high cell recovery yields (>70%) after cryopreservation. When compared with non-encapsulated cells, cell survival post-thawing demonstrated a three-fold improvement without compromising hESC characteristics.Microencapsulation also improved the culture of hESC aggregates by protecting cells from hydrodynamic shear stress, controlling aggregate size and maintaining cell pluripotency for two weeks.This work establishes that microencapsulation technology may prove a powerful tool for integrating the expansion and cryopreservation of pluripotent hESCs. The 3D culture strategy developed herein represents a significant breakthrough towards the implementation of hESCs in clinical and industrial applications.

  2. Ergonomics applications of a mechanical model of the human operator in power hand tool operation.

    Science.gov (United States)

    Lin, Jia-Hua; Radwin, Robert; Nembhard, David

    2005-02-01

    Applications of a new model for predicting power threaded-fastener-driving tool operator response and capacity to react against impulsive torque reaction forces are explored for use in tool selection and ergonomic workplace design. The model is based on a mechanical analog of the human operator, with parameters dependent on work location (horizontal and vertical distances); work orientation (horizontal and vertical); and tool shape (in-line, pistol grip, and right angle); and is stratified by gender. This model enables prediction of group means and variances of handle displacement and force for a given tool configuration. Response percentiles can be ascertained for specific tool operations. For example, a sample pistol grip nutrunner used on a horizontal surface at 30 cm in front of the ankles and 140 cm above the floor results in a predicted mean handle reaction displacement of 39.0 (SD=28.1) mm for males. Consequently 63%of the male users exceed a 30 mm handle displacement limit. When a right angle tool of similar torque output is used instead, the model predicted that only 4.6%of the male tool users exceed a 30 mm handle displacement. A method is described for interpolating individual subject model parameters at any given work location using linear combinations in relation to the range of modeled factors. Additional examples pertinent to ergonomic workstation design and tool selection are provided to demonstrate how the model can be used to aid tool selection and workstation design.

  3. Expression of Heat Shock Proteins in Human Fibroblast Cells under Magnetic Resonant Coupling Wireless Power Transfer

    Directory of Open Access Journals (Sweden)

    Kohei Mizuno

    2015-10-01

    Full Text Available Since 2007, resonant coupling wireless power transfer (WPT technology has been attracting attention and has been widely researched for practical use. Moreover, dosimetric evaluation has also been discussed to evaluate the potential health risks of the electromagnetic field from this WPT technology based on the International Commission on Non-Ionizing Radiation Protection (ICNIRP guidelines. However, there has not been much experimental evaluation of the potential health risks of this WPT technology. In this study, to evaluate whether magnetic resonant coupling WPT induces cellular stress, we focused on heat shock proteins (Hsps and determined the expression level of Hsps 27, 70 and 90 in WI38VA13 subcloned 2RA human fibroblast cells using a western blotting method. The expression level of Hsps under conditions of magnetic resonant coupling WPT for 24 h was not significantly different compared with control cells, although the expression level of Hsps for cells exposed to heat stress conditions was significantly increased. These results suggested that exposure to magnetic resonant coupling WPT did not cause detectable cell stress.

  4. Microencapsulation technology: a powerful tool for integrating expansion and cryopreservation of human embryonic stem cells.

    Directory of Open Access Journals (Sweden)

    Margarida Serra

    Full Text Available The successful implementation of human embryonic stem cells (hESCs-based technologies requires the production of relevant numbers of well-characterized cells and their efficient long-term storage. In this study, cells were microencapsulated in alginate to develop an integrated bioprocess for expansion and cryopreservation of pluripotent hESCs. Different three-dimensional (3D culture strategies were evaluated and compared, specifically, microencapsulation of hESCs as: i single cells, ii aggregates and iii immobilized on microcarriers. In order to establish a scalable bioprocess, hESC-microcapsules were cultured in stirred tank bioreactors.The combination of microencapsulation and microcarrier technology resulted in a highly efficient protocol for the production and storage of pluripotent hESCs. This strategy ensured high expansion ratios (an approximately twenty-fold increase in cell concentration and high cell recovery yields (>70% after cryopreservation. When compared with non-encapsulated cells, cell survival post-thawing demonstrated a three-fold improvement without compromising hESC characteristics.Microencapsulation also improved the culture of hESC aggregates by protecting cells from hydrodynamic shear stress, controlling aggregate size and maintaining cell pluripotency for two weeks.This work establishes that microencapsulation technology may prove a powerful tool for integrating the expansion and cryopreservation of pluripotent hESCs. The 3D culture strategy developed herein represents a significant breakthrough towards the implementation of hESCs in clinical and industrial applications.

  5. Conformal dynamical equivalence and applications

    Science.gov (United States)

    Spyrou, N. K.

    2011-02-01

    The "Conformal Dynamical Equivalence" (CDE) approach is briefly reviewed, and some of its applications, at various astrophysical levels (Sun, Solar System, Stars, Galaxies, Clusters of Galaxies, Universe as a whole), are presented. According to the CDE approach, in both the Newtonian and general-relativistic theories of gravity, the isentropic hydrodynamic flows in the interior of a bounded gravitating perfect-fluid source are dynamically equivalent to geodesic motions in a virtual, fully defined fluid source. Equivalently, the equations of hydrodynamic motion in the former source are functionally similar to those of the geodesic motions in the latter, physically, fully defined source. The CDE approach is followed for the dynamical description of the motions in the fluid source. After an observational introduction, taking into account all the internal physical characteristics of the corresponding perfect-fluid source, and based on the property of the isentropic hydrodynamic flows (quite reasonable for an isolated physical system), we examine a number of issues, namely, (i) the classical Newtonian explanation of the celebrated Pioneer-Anomaly effect in the Solar System, (ii) the possibility of both the attractive gravity and the repulsive gravity in a non-quantum Newtonian framework, (iii) the evaluation of the masses - theoretical, dynamical, and missing - and of the linear dimensions of non-magnetized and magnetized large-scale cosmological structures, (iv) the explanation of the flat-rotation curves of disc galaxies, (v) possible formation mechanisms of winds and jets, and (vi) a brief presentation of a conventional approach - toy model to the dynamics of the Universe, characterized by the dominant collisional dark matter (with its subdominant luminous baryonic "contamination"), correctly interpreting the cosmological observational data without the need of the notions dark energy, cosmological constant, and universal accelerating expansion.

  6. Equivalence principle in Chameleon models .

    Science.gov (United States)

    Kraiselburd, L.; Landau, S.; Salgado, M.; Sudarsky, D.

    Most theories that predict time and/or space variation of fundamental constants also predict violations of the Weak Equivalence Principle (WEP). Khoury and Weltmann proposed the chameleon model in 2004 and claimed that this model avoids experimental bounds on WEP. We present a contrasting view based on an approximate calculation of the two body problem for the chameleon field and show that the force depends on the test body composition. Furthermore, we compare the prediction of the force on a test body with Eötvös type experiments and find that the chameleon field effect cannot account for current bounds.

  7. Thermodynamic equivalence of spin systems

    Energy Technology Data Exchange (ETDEWEB)

    Beltman, J.M. (Katholieke Universiteit Nijmegen (Netherlands))

    1975-01-01

    The thermodynamic equilibrium properties of systems composed of classical spin /sup 1///sub 2/ particles (Ising spins) are studied. Given an interaction pattern between the Ising spins the main problem is to calculate the equilibrium state(s) of the system. The point put forward here is the existence of many thermodynamical equivalent spin coordinate systems. As a consequence of this phenomenon the interaction pattern of a system may be very intricate when described with respect to one spin coordinate system whereas it may become simple with respect to another one and vice versa. A systematic investigation of this phenomenon is made. (FR)

  8. Blast Wave Characteristics and Equivalency

    OpenAIRE

    Sochet, Isabelle; Schneider, Helmut

    2010-01-01

    ISBN 978-5-94588-079-5; The characteristics of blast waves generated by detonation of gas clouds are studies theoretically and validated by both small-scale and large-scale experiments with ethylene-air mixtures of different equivalence ratio. The mixtures were confined in hemispherical or spherical balloons made from thin polyethylene foils of 0.75 m³ and 15 m³ in volume. The detonation of gas mixtures was initiated by a solid explosive. The characteristics of the blast wave in terms of over...

  9. Equivalence Principle in Chameleon Models

    CERN Document Server

    Kraiselburd, Lucila; Salgado, Marcelo; Sudarsky, Daniel

    2013-01-01

    Most theories that predict time and/or space variation of fundamental constants also predict violations of the Weak Equivalence Principle (WEP). Khoury and Weltmann proposed the chameleon model in 2004 and claimed that this model avoids experimental bounds on WEP. We present a contrasting view based on an approximate calculation of the two body problem for the chameleon field and show that the force depends on the test body composition. Furthermore, we compare the prediction of the force on a test body with E\\"otv\\"os type experiments and find that the chameleon field effect cannot account for current bounds.

  10. On Vasyliunas's equivalent conductivity formalism

    Science.gov (United States)

    Pontius, D. H., Jr.

    1992-01-01

    The Vasyliunas's (1972) equivalent conductivity formalism (ECF) for representing the coupling of the ionosphere and the magnetosphere is discussed, and a new, simpler, derivation is presented of the ECF, in which certain of the underlying assumptions and their implications are made transparent. The derivation presented indicates that the only role of the ions in the ECF is to insure quasi-neutrality. It is shown that the ECF is not as robust as usually assumed and that caution must be used to insure that reasonable results are obtained.

  11. The transfer of avoidance evoking functions through stimulus equivalence classes.

    Science.gov (United States)

    Augustson, E M; Dougher, M J

    1997-09-01

    Recent research in the area of stimulus equivalence suggests that transfer of function via members of stimulus equivalence classes may have relevance to human emotional responding and the development and generalization of certain psychological disorders. This study investigated the transfer of avoidance evoking functions through equivalence classes. Eight subjects were trained in the necessary relations for two-four member stimulus equivalence classes to emerge. Next, using an on-baseline classical conditioning procedure, one member of one class was paired with shock while one member of the other class was presented without shock. Then, while subjects engaged a key-press task, a differential, signalled avoidance task was introduced wherein shock was avoided if a response occurred to the stimulus previously associated with shock. The remaining stimuli from both classes were then presented. The behavior of all eight subjects showed the differential transfer of the avoidance evoking function. The clinical and theoretical implications of the results are discussed.

  12. Circadian variation of EEG power spectra in NREM and REM sleep in humans: dissociation from body temperature

    Science.gov (United States)

    Dijk, D. J.

    1999-01-01

    In humans, EEG power spectra in REM and NREM sleep, as well as characteristics of sleep spindles such as their duration, amplitude, frequency and incidence, vary with circadian phase. Recently it has been hypothesized that circadian variations in EEG spectra in humans are caused by variations in brain or body temperature and may not represent phenomena relevant to sleep regulatory processes. To test this directly, a further analysis of EEG power spectra - collected in a forced desynchrony protocol in which sleep episodes were scheduled to a 28-h period while the rhythms of body temperature and plasma melatonin were oscillating at their near 24-h period - was carried out. EEG power spectra were computed for NREM and REM sleep occurring between 90-120 and 270-300 degrees of the circadian melatonin rhythm, i.e. just after the clearance of melatonin from plasma in the 'morning' and just after the 'evening' increase in melatonin secretion. Average body temperatures during scheduled sleep at these two circadian phases were identical (36.72 degrees C). Despite identical body temperatures, the power spectra in NREM sleep were very different at these two circadian phases. EEG activity in the low frequency spindle range was significantly and markedly enhanced after the evening increase in plasma melatonin as compared to the morning phase. For REM sleep, significant differences in power spectra during these two circadian phases, in particular in the alpha range, were also observed. The results confirm that EEG power spectra in NREM and REM sleep vary with circadian phase, suggesting that the direct contribution of temperature to the circadian variation in EEG power spectra is absent or only minor, and are at variance with the hypothesis that circadian variations in EEG power spectra are caused by variations in temperature.

  13. Single-channel power meter for registration of human millimeter radiation

    Directory of Open Access Journals (Sweden)

    Ya. V. Savenko

    2013-07-01

    Full Text Available Introduction. The development of modern techniques for noninvasive diagnostic sets requirements to ensure complete diagnostic safety, efficiency, comprehensiveness while maintaining high reliability of quantitative results. One of the promising directions for creating such devices is based on the idea of using information properties of the extra low millimeter-wave radiation from the human body or other biological objects. Problem definition. The main difficulty in registration of such radiation is associated with exceptionally low power electromagnetic field generated by the body and the absence lack of opportunities for effective their reception by the radiation sensitive receivers. This is a significant issue of physical media relevant information signals that ensure effective processes in the body. Solutions to the problem. The absence of a necessary equipment for electromagnetic radiation registration of millimeter range extra low radiation until now makes impossible the diagnostics in this range. Power meter based on semiconductor sensors can improve the compactness of equipment, ease of use and efficiency in diagnostics. Description of the model and experiment. The receiver located on the surface of the skin can get a signal from the cell body. The information status of cells in the deeper layers of the body is transferred to the surface of cells and is a modulating factor for the generated millimeter radiation. Three basic hardware portions that make up its technical support should be included in the diagnostic system. There are antenna measuring unit and interface process unit, storage and presentation of information. These signals can be detected and processed by a computer. The range of information signals estimated spectral characteristics of low-frequency envelope of the received signal can be used as informative features. Application. Any disease of the body changes metabolic processes in cells, thereby initiating the process of

  14. ASCERTAINMENT OF THE EQUIVALENT CIRCUIT PARAMETERS OF THE ASYNCHRONOUS MACHINE

    Directory of Open Access Journals (Sweden)

    V. S. Safaryan

    2015-01-01

    Full Text Available The article considers experimental and analytical determination of the asynchronous machine equivalent-circuit parameters with application of the reference data. Transient processes investigation of the asynchronous machines necessitates the equivalent circuit parameters (resistance impedance, inductances and coefficient of the stator-rotor contours mutual inductance that help form the transitory-process mathematical simulation model. The reference books do not provide those parameters; they instead give the rated ones (active power, voltage, slide, coefficient of performance and capacity coefficient as well as the ratio of starting and nominal currents and torques. The noted studies on the asynchronous machine equivalent-circuits parametrization fail to solve the problems ad finem or solve them with admissions. The paper presents experimental and analytical determinations of the asynchronous machine equivalent-circuit parameters: the experimental one based on the results of two measurements and the analytical one where the problem boils down to solving a system of nonlineal algebraic equations. The authors investigate the equivalent asynchronous machine input-resistance properties and adduce the dependence curvatures of the input-resistances on the slide. They present a symbolic model for analytical parameterization of the asynchronous machine equivalent-circuit that represents a system of nonlineal equations and requires one of the rotor-parameters arbitrary assignment. The article demonstrates that for the asynchronous machine equivalent-circuit experimental parameterization the measures are to be conducted of the stator-circuit voltage, current and active power with two different slides and arbitrary assignment of one of the rotor parameters. The paper substantiates the fact that additional measurement does not discard the rotor-parameter choice arbitrariness. The authors establish that in motoring mode there is a critical slide by which the

  15. Ultrastructure and penetration of cell co-culture model of human skin equivalent%细胞共培养人体皮肤类似物超微结构观察及其渗透性测试

    Institute of Scientific and Technical Information of China (English)

    李辉; 王景雁; 林红梅; 于竞新; 章烨雯; 毛颖秋; 吴清

    2016-01-01

    目的:观察人体皮肤类似物模型形态结构,对其屏障功能进行初步评价。方法通过胶原蛋白包被成纤维细胞,制备真皮层,真皮层表面接种角质细胞,浸没培养1周后,气-液界面培养以促进角质细胞的分化形成角质层,3周后收获皮肤模型;通过肉眼观察、电镜观察皮肤类似物的宏观结构和超微结构;以吲哚美辛作为模型药物,进行体外透皮实验考察细胞共培养皮肤类似物模型的屏障功能。结果皮肤类似物形成与人类皮肤相似的真皮层和表皮层,表皮层表面形成完整的角质层,具有与人类皮肤类似的超微结构;24 h 内渗透性实验结果显示皮肤类似物屏障功能略低于大鼠腹部皮肤,但22~24 h,皮肤类似物对模型药的透过速率远小于大鼠腹部皮肤(约为其28%),且2种皮肤模型对吲哚美辛经皮渗透的稳态流速没有显著性差异(P >0.05)。结论皮肤类似物有与人体皮肤相类似的形态结构特征,与大鼠腹部皮肤相比对吲哚美辛有相似的屏障作用,有望替代动物皮肤成为经皮给药系统评价的新型皮肤模型。%Abatract:Objective To observe the structure of human skin equivalent (HSE)model in vitro,and to preliminarily assess the barrier function of HSE.Methods The HSE model was established by two steps:preparation of dermal layer and preparation of full-thickness skin.Keratinocytes were inoculated on the surface of dermal layer prepared by type 1 collagen coating fibroblasts.After submerged cultured for one week,air-liquid interface cultured for three weeks to enhance the proliferation of keratinocytes,the HSE model was obtained.Then the macroscopical structure and electon microscopical structure of HSE were studied.To investigate the barrier function of HSE model,indometacin was selected as the model drug for the penetration testing in vitro.Results The structures similar to dermal layer and

  16. Muscle contractile properties as an explanation of the higher mean power output in marmosets than humans during jumping.

    Science.gov (United States)

    Plas, Rogier L C; Degens, Hans; Meijer, J Peter; de Wit, Gerard M J; Philippens, Ingrid H C H M; Bobbert, Maarten F; Jaspers, Richard T

    2015-07-01

    The muscle mass-specific mean power output (PMMS,mean) during push-off in jumping in marmosets (Callithrix jacchus) is more than twice that in humans. In the present study it was tested whether this is attributable to differences in muscle contractile properties. In biopsies of marmoset m. vastus lateralis (VL) and m. gastrocnemius medialis (GM) (N=4), fibre-type distribution was assessed using fluorescent immunohistochemistry. In single fibres from four marmoset and nine human VL biopsies, the force-velocity characteristics were determined. Marmoset VL contained almost exclusively fast muscle fibres (>99.0%), of which 63% were type IIB and 37% were hybrid fibres, fibres containing multiple myosin heavy chains. GM contained 9% type I fibres, 44% type IIB and 47% hybrid muscle fibres. The proportions of fast muscle fibres in marmoset VL and GM were substantially larger than those reported in the corresponding human muscles. The curvature of the force-velocity relationships of marmoset type IIB and hybrid fibres was substantially flatter than that of human type I, IIA, IIX and hybrid fibres, resulting in substantially higher muscle fibre mass-specific peak power (PFMS,peak). Muscle mass-specific peak power output (PMMS,peak) values of marmoset whole VL and GM, estimated from their fibre-type distributions and force-velocity characteristics, were more than twice the estimates for the corresponding human muscles. As the relative difference in estimated PMMS,peak between marmosets and humans is similar to that of PMMS,mean during push-off in jumping, it is likely that the difference in in vivo mechanical output between humans and marmosets is attributable to differences in muscle contractile properties.

  17. Multigroup Equivalence Analysis for High-Dimensional Expression Data

    Science.gov (United States)

    Yang, Celeste; Bartolucci, Alfred A.; Cui, Xiangqin

    2015-01-01

    Hypothesis tests of equivalence are typically known for their application in bioequivalence studies and acceptance sampling. Their application to gene expression data, in particular high-dimensional gene expression data, has only recently been studied. In this paper, we examine how two multigroup equivalence tests, the F-test and the range test, perform when applied to microarray expression data. We adapted these tests to a well-known equivalence criterion, the difference ratio. Our simulation results showed that both tests can achieve moderate power while controlling the type I error at nominal level for typical expression microarray studies with the benefit of easy-to-interpret equivalence limits. For the range of parameters simulated in this paper, the F-test is more powerful than the range test. However, for comparing three groups, their powers are similar. Finally, the two multigroup tests were applied to a prostate cancer microarray dataset to identify genes whose expression follows a prespecified trajectory across five prostate cancer stages. PMID:26628859

  18. Multigroup Equivalence Analysis for High-Dimensional Expression Data.

    Science.gov (United States)

    Yang, Celeste; Bartolucci, Alfred A; Cui, Xiangqin

    2015-01-01

    Hypothesis tests of equivalence are typically known for their application in bioequivalence studies and acceptance sampling. Their application to gene expression data, in particular high-dimensional gene expression data, has only recently been studied. In this paper, we examine how two multigroup equivalence tests, the F-test and the range test, perform when applied to microarray expression data. We adapted these tests to a well-known equivalence criterion, the difference ratio. Our simulation results showed that both tests can achieve moderate power while controlling the type I error at nominal level for typical expression microarray studies with the benefit of easy-to-interpret equivalence limits. For the range of parameters simulated in this paper, the F-test is more powerful than the range test. However, for comparing three groups, their powers are similar. Finally, the two multigroup tests were applied to a prostate cancer microarray dataset to identify genes whose expression follows a prespecified trajectory across five prostate cancer stages.

  19. The Human Powered Submarine Team of Virginia Tech Propulsion System Design Final Report

    Science.gov (United States)

    An, Eric; Bennett, Matt; Callis, Ron; Chen, Chester; Lee, John; Milan-Williams, Kristy

    1999-01-01

    The Human Powered Submarine Team has been in existence at Virginia Tech since its conception in 1993. Since then, it has served as a way for engineering students from many different disciplines to implement design conception and realization. The first submarine built was Phantom 1, a two-man submarine made of fiberglass. After construction was complete, Phantom 1 was ready for racing, but, unfortunately, suffered fatal problems come race time. The submarine team slowed down a bit after experiencing racing problems, but was revived in 1995 when design efforts for a new two-man submarine, the Phantom 2 commence. The propulsion system consisted of a chain and gear drive system using an ultra-light helicopter tail rotor for a propeller. Although the team learned valuable lessons as a result of Phantom 1's problems, Phantom 2 still experiences problems at races. After various parts of Phantom 2 are redesigned, it is once again ready for racing and proves that the redesign was well worth the time and effort. In 1997, Phantom 2 not only finishes its first race, held in San Diego, California, but comes in third. This success sparks yet another revival of the submarine team and design for the team's current project, the Phantom 3, a one-man submarine, is started. In 1998, the plug for Phantom 3 is built and the hull is constructed. With so many past problems from which to learn, Phantom 3 promises to be the fastest and best-designed submarine the team has developed thus far. The current speed world-record is 7 knots.

  20. Thévenin equivalent based static contingency assessment

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a method for static security assessment of a power system and a real time static security assessment system for assessing a power system, the power system having a plurality of generators, the plurality of generators being represented in the network by a plurality...... of voltage controlled nodes, wherein the method for static security assessment of the power system comprises receiving information of a present state of the power system, determining a Thevenin equivalent for each voltage controlled node, determining for each voltage controlled node on basis......, and evaluating the voltage angles to determine whether the network having at least one contingency admit a steady state. Also a method of providing information on a real time static security assessment of a power system is disclosed....

  1. Strip Waveguide Directional Coupling Modulator with Equivalent Refractive Index

    Institute of Scientific and Technical Information of China (English)

    LI Hong-tao; HE Dui-yan

    2004-01-01

    The equivalent refractive index(ERI) method is employed to analyze the function of the strip waveguide directional coupling modulator(SWM). Through deducing the diagnostic equation of the Exmn mode of the four-layer media film waveguide equivalent to the SWM,the transmission constant of the symmetrical mode of the positive phase and negative one and the coupling length of powerful transference are obtained. The veracity of ERI is validated with the example of Ex11 basal mode under the condition of comparing the three results of ERI,EIM and Marcatili.

  2. Cultivo in vitro con colágeno y fibroblastos humanos de un equivalente de mucosa oral de espesor total In vitro culture with collagen and human fibroblasts of a full-thickness oral mucosa equivalent

    Directory of Open Access Journals (Sweden)

    S. González Mendez

    2009-04-01

    free skin grafts or autologous oral mucosa grafts by this technique in certain cases. Material and Method. Primary keratinocyte cultures were prepared from small biopsy samples of oral mucosa. Secondary cultures were prepared from these primary cultures on an artificial submucosa constituted by collagen and human fibroblasts. The cell cultures were analyzed histologically in vitro and then used for graft implants in athymic mice to study their behavior in vivo. Results. The primary cultures were confluent within a minimum period of 10 days and maximum of 12 days, which is similar to the period that the secondary cultures required to reach confluence. The time from sampling to achieving a complete artificial mucosa ranged from 20 to 22 days. The artificial mucosa showed histologic characteristics of a normal mucosa. After 17 days of graft implantation in immunoincompetent mice without any clinical contingency, histologic and immunohistochemical characterization (cytokeratins 19 and 13, collagen IV, and laminin confirmed the similarity of the mucosa in vitro to healthy oral mucosa. Conclusion. A complete oral mucosa equivalent can be prepared with collagen and fibroblasts using in vitro culture techniques. Although this mucosa shows considerable retraction, its clinical handling is very favorable.

  3. Equivalency of Artificial and Natural Icing

    Institute of Scientific and Technical Information of China (English)

    wgI Xiao-xing; XU Zhi-hai; LI Zhi-ning; SU Hua-feng; JIA Zhi-dong; GUAN Zhi-cheng

    2011-01-01

    Climate room is an important instrument to study the icing problems in power networks, and the accuracy of the data from the climate room is under debate. There are many climate rooms in the world, but no standards about the parameters of the climate room such as the room's temperature, the velocity of the wind, and the particle diameters of the water droplets etc. These parameters will influence the icing processes on the lines and insulators. This paper gave a summary of the process and the feature of atmospheric icing of power networks. The speed of the icing on a cylinder rod as a new characteristic quantity was proposed to study the de-icing problems in this paper. For the purpose to analyze the equivalence between atmospheric icing and icing in climate room, a finite element model was made based on a small climate room located in the Graduate School at Shenzhen, Tsinghua University. Through the simulation analysis for the heat transfer and flow issues, the result showed that precooling droplets were cooled into supercooled ones soon after they came into the climate room. Based on the most serious icing-speed in Hengshan, Hunan and a series of experiments, the values of some parameters in studying icing problems were proposed to better simulate the atmospheric icing in climate room.

  4. SONOPHORESIS EFFECT ON THE PERMEATION OF METRONIDAZOLE USING 3D SKIN EQUIVALENT

    Directory of Open Access Journals (Sweden)

    Mai Aldwaikat*, Mohammed Alarjah , Jacki Willis and Timothy Mason

    2013-01-01

    Full Text Available Transdermal drug delivery is highly advantageous method for drug administration, yet the compact structure of stratum corneum is an effective barrier which limited the use of this route to very few drug molecules. Ultrasound enhances the permeation through the skin by altering this barrier function in a phenomenon named sonophoresis. This study aimed to evaluate the effect of variable ultrasonic conditions on the permeation of Metronidazole (ML. This involved validating the applicability of utilizing a three dimensional skin equivalent as human skin models for sonophoresis studies. A Franz diffusion cell was used to study the effect of therapeutic ultrasound at 1 MHz and power ultrasound at 20 KHz on the permeation of Metronidazole across the 3D skin equivalent EpiDerm™. HPLC methods were used for the determination of the concentration of Metronidazole in the receiving compartment. Utilizing therapeutic ultrasound at 1 MHz frequency has enhanced the permeation of Metronidazole through the EpiDerm™, as about double the permeation of the ML was obtained with no apparent damage to the membrane. The results indicated significant permeation enhancement with low frequency sonophoresis at 20 KHz frequency treatments through EpiDerm™ skin equivalent. Up to five fold enhancement was measured with the permeation of investigated molecules through EpiDerm™. The mechanism of action observed seemed highly dependent on the ultrasonic conditions.

  5. Einstein's equivalence principle in cosmology

    CERN Document Server

    Kopeikin, Sergei M

    2013-01-01

    We study physical consequences of the Einstein equivalence principle (EEP) for a Hubble observer in FLRW universe. We introduce the local inertial coordinates with the help of a special conformal transformation. The local inertial metric is Minkowski flat and materialized by a congruence of time-like geodesics of static observers. The static observers are equipped with the ideal clocks measuring the proper time that is synchronized with the clocks of the Hubble observer. The local inertial metric is used for physical measurements of spacetime intervals with the ideal clocks and rulers. The special conformal transformation preserves null geodesics but does not keep invariant time-like geodesics. Moreover, it makes the rate of the local time coordinate dependent on velocity of the particle which makes impossible to rich the uniform parameterization of the world lines of static observers and light geodesics with a single parameter - they differ by the conformal factor of FLRW metric. The most convenient way to s...

  6. ROMANIC EQUIVALENTS FOR LATIN IDIOMS

    Directory of Open Access Journals (Sweden)

    Dr. Stefan DUMITRU

    2010-11-01

    Full Text Available In this study we set forth to present several of the most important aspects regarding the contrastive analysis of a well-defined number of Latin idioms in parallel with their Romanic counterparts (in French, Italian, Spanish and Romanian. Our intent was not to discover, in the Romanic space, all the equivalents of the phrases that form the corpus we work with, for reasons pertaining to material restrictions, but to discuss, based on a certain number of units, the different types of issues they may point to. The most important is to establish the relation between the idiomatic expressions in Latin and their correspondents in the above mentioned languages, regarding their inner form, their meaning and their structure.

  7. Electroweak Vortices and Gauge Equivalence

    Science.gov (United States)

    MacDowell, Samuel W.; Törnkvist, Ola

    Vortex configurations in the electroweak gauge theory are investigated. Two gauge-inequivalent solutions of the field equations, the Z and W vortices, have previously been found. They correspond to embeddings of the Abelian Nielsen-Olesen vortex solution into a U(1) subgroup of SU(2)×U(1). It is shown here that any electroweak vortex solution can be mapped into a solution of the same energy with a vanishing upper component of the Higgs field. The correspondence is a gauge equivalence for all vortex solutions except those for which the winding numbers of the upper and lower Higgs components add to zero. This class of solutions, which includes the W vortex, corresponds to a singular solution in the one-component gauge. The results, combined with numerical investigations, provide an argument against the existence of other vortex solutions in the gauge-Higgs sector of the Standard Model.

  8. Expanding the Interaction Equivalency Theorem

    Directory of Open Access Journals (Sweden)

    Brenda Cecilia Padilla Rodriguez

    2015-06-01

    Full Text Available Although interaction is recognised as a key element for learning, its incorporation in online courses can be challenging. The interaction equivalency theorem provides guidelines: Meaningful learning can be supported as long as one of three types of interactions (learner-content, learner-teacher and learner-learner is present at a high level. This study sought to apply this theorem to the corporate sector, and to expand it to include other indicators of course effectiveness: satisfaction, knowledge transfer, business results and return on expectations. A large Mexican organisation participated in this research, with 146 learners, 30 teachers and 3 academic assistants. Three versions of an online course were designed, each emphasising a different type of interaction. Data were collected through surveys, exams, observations, activity logs, think aloud protocols and sales records. All course versions yielded high levels of effectiveness, in terms of satisfaction, learning and return on expectations. Yet, course design did not dictate the types of interactions in which students engaged within the courses. Findings suggest that the interaction equivalency theorem can be reformulated as follows: In corporate settings, an online course can be effective in terms of satisfaction, learning, knowledge transfer, business results and return on expectations, as long as (a at least one of three types of interaction (learner-content, learner-teacher or learner-learner features prominently in the design of the course, and (b course delivery is consistent with the chosen type of interaction. Focusing on only one type of interaction carries a high risk of confusion, disengagement or missed learning opportunities, which can be managed by incorporating other forms of interactions.

  9. Equivalent damage of loads on pavements

    CSIR Research Space (South Africa)

    Prozzi, JA

    2009-05-26

    Full Text Available This report describes a new methodology for the determination of Equivalent Damage Factors (EDFs) of vehicles with multiple axle and wheel configurations on pavements. The basic premise of this new procedure is that "equivalent pavement response...

  10. Discovering Classes of Strongly Equivalent Logic Programs

    OpenAIRE

    Chen, Y.; Lin, F.

    2011-01-01

    In this paper we apply computer-aided theorem discovery technique to discover theorems about strongly equivalent logic programs under the answer set semantics. Our discovered theorems capture new classes of strongly equivalent logic programs that can lead to new program simplification rules that preserve strong equivalence. Specifically, with the help of computers, we discovered exact conditions that capture the strong equivalence between a rule and the empty set, between two rules, between t...

  11. Diminished acquired equivalence yet good discrimination performance in older participants.

    Science.gov (United States)

    Robinson, Jasper; Owens, Emma

    2013-01-01

    We asked younger and older human participants to perform computer-based configural discriminations that were designed to detect acquired equivalence. Both groups solved the discriminations but only the younger participants demonstrated acquired equivalence. The discriminations involved learning the preferences ["like" (+) or "dislike" (-)] for sports [e.g., tennis (t) and hockey (h)] of four fictitious people [e.g., Alice (A), Beth (B), Charlotte (C), and Dorothy (D)]. In one experiment, the discrimination had the form: At+, Bt-, Ct+, Dt-, Ah-, Bh+, Ch-, Dh+. Notice that, e.g., Alice and Charlotte are "equivalent" in liking tennis but disliking hockey. Acquired equivalence was assessed in ancillary components of the discrimination (e.g., by looking at the subsequent rate of "whole" versus "partial" reversal learning). Acquired equivalence is anticipated by a network whose hidden units are shared when inputs (e.g., A and C) signal the same outcome (e.g., +) when accompanied by the same input (t). One interpretation of these results is that there are age-related differences in the mechanisms of configural acquired equivalence.

  12. Classroom Activities for Introducing Equivalence Relations

    Science.gov (United States)

    Brandt, Jim

    2013-01-01

    Equivalence relations and partitions are two interconnected ideas that play important roles in advanced mathematics. While students encounter the informal notion of equivalence in many courses, the formal definition of an equivalence relation is typically introduced in a junior level transition-to-proof course. This paper reports the results of a…

  13. Human Muscle Power Output during Upper- and Lower-Body Exercises.

    Science.gov (United States)

    Siegel, Judith A.; Gilders, Roger M.; Staron, Robert S.; Hagerman, Fredrick C.

    2002-01-01

    Evaluated the use of traditional resistance training equipment in measuring muscular power, measuring the velocity of movement through a measured distance during maximal effort lifts using a Smith rack. Data collected on male volunteers indicated that this method of evaluating muscle power was reliable, although it was not predictive of muscle…

  14. Steganographic Capacity of Images, based on Image Equivalence Classes

    DEFF Research Database (Denmark)

    Hansen, Klaus; Hammer, Christian; Andersen, Jens Damgaard

    2001-01-01

    The problem of hiding information imperceptibly can be formulated as the problem of determining if a given image is a member of a sufficiently large equivalence class of images which to the Human Visual System appears to be the same image. This makes it possible to replace the given image with a ...

  15. SELF-DETERMINATION AND POWER: A HUMAN-CENTRIC APPROACH TO THE INTERNATIONAL RELATIONS

    Directory of Open Access Journals (Sweden)

    Shameer Modongal

    2017-05-01

    Full Text Available This paper analyzes the importance of self-determination in international relations. It explains the puzzle why some small regions or group of people are ready to be small states by separating from big powerful states. The self-determination of a nation is preferable to the people than a military power of the large state. The military power of a state may not translate into a better life of people. So people’s empowerment cannot be treated the necessary outcome of state’s military power. When one group of people feel as marginalized in national policymaking and its implications, they show a secessionist tendency. This paper contends that people may prefer their ideology, identity and self-determination than the power of the state.

  16. Drive Control Scheme of Electric Power Assisted Wheelchair Based on Neural Network Learning of Human Wheelchair Operation Characteristics

    Science.gov (United States)

    Tanohata, Naoki; Seki, Hirokazu

    This paper describes a novel drive control scheme of electric power assisted wheelchairs based on neural network learning of human wheelchair operation characteristics. “Electric power assisted wheelchair” which enhances the drive force of the operator by employing electric motors is expected to be widely used as a mobility support system for elderly and disabled people. However, some handicapped people with paralysis of the muscles of one side of the body cannot maneuver the wheelchair as desired because of the difference in the right and left input force. Therefore, this study proposes a neural network learning system of such human wheelchair operation characteristics and a drive control scheme with variable distribution and assistance ratios. Some driving experiments will be performed to confirm the effectiveness of the proposed control system.

  17. Testing for Equivalence: A Methodology for Computational Cognitive Modelling

    Science.gov (United States)

    Stewart, Terrence; West, Robert

    2010-12-01

    The equivalence test (Stewart and West, 2007; Stewart, 2007) is a statistical measure for evaluating the similarity between a model and the system being modelled. It is designed to avoid over-fitting and to generate an easily interpretable summary of the quality of a model. We apply the equivalence test to two tasks: Repeated Binary Choice (Erev et al., 2010) and Dynamic Stocks and Flows (Gonzalez and Dutt, 2007). In the first case, we find a broad range of statistically equivalent models (and win a prediction competition) while identifying particular aspects of the task that are not yet adequately captured. In the second case, we re-evaluate results from the Dynamic Stocks and Flows challenge, demonstrating how our method emphasizes the breadth of coverage of a model and how it can be used for comparing different models. We argue that the explanatory power of models hinges on numerical similarity to empirical data over a broad set of measures.

  18. Functional equivalence between radial basis function networks and fuzzy inference systems.

    Science.gov (United States)

    Jang, J R; Sun, C T

    1993-01-01

    It is shown that, under some minor restrictions, the functional behavior of radial basis function networks (RBFNs) and that of fuzzy inference systems are actually equivalent. This functional equivalence makes it possible to apply what has been discovered (learning rule, representational power, etc.) for one of the models to the other, and vice versa. It is of interest to observe that two models stemming from different origins turn out to be functionally equivalent.

  19. The Thermal Economic Analysis for Thermal Power Generating Units Based on Quality Coefficient of Equivalent Exergy-drop%基于等效(火用)降品质系数的火力发电机组热经济学分析

    Institute of Scientific and Technical Information of China (English)

    李慧君; 马超; 谷凯娜; 彭文平

    2013-01-01

    The concept of quality coefficient of equivalent exergy-drop is introduced to the article. θe can be used to judge the exergy-power conversion capacity of the exergy flows in the thermal equipment, thus determine their exergy unit price, and construct the thermal economic supplementary equation in the view of exergy-power conversion. This coefficient is used to calculate the exergy flow price of one 1 000MW unit thermal system, and the calculation results are compared with the results of Valero method and Energy quality coefficient method. This coefficient not only reflects the quality and price of exergy flows, but also takes the exergy-power conversion capacity of the thermal equipment into account, which makes exergy cost calculation more scientific and reasonable.%提出等效(火用)降品质系数θe的概念,根据θe的大小判断燃料(火用)流在各热力设备处的热量(火用)变功能力,进而确定其(火用)单价,从(火用)变功的角度合理构造了热经济学补充方程;利用该系数对某1 000MW机组热力系统进行了(火用)流的(火用)单价计算,并将计算结果与Valero方法、能质系数法进行了分析比较.该系数不仅体现了(火用)流的品质和价格,而且考虑到设备处的热量(火用)变功能力对(火用)成本的影响,使(火用)成本计算更科学合理.

  20. Equivalence Principle in Chameleon Models

    CERN Document Server

    Kraiselburd, Lucila; Salgado, Marcelo; Sudarsky, Daniel; Vucetich, Héctor

    2015-01-01

    Most theories that predict time and(or) space variation of fundamental constants also predict violations of the Weak Equivalence Principle (WEP). Khoury and Weltman proposed the chameleon model in 2004 and claimed that this model avoids experimental bounds on the WEP. In this paper we present a contrasting view based on the analysis of the force between two bodies induced by the chameleon field using a particular approach in which the field due to both the large and the small bodies is obtained by appropriate series expansions in the various regions of interest and the corresponding matching conditions. We found that resulting force depends on the test body\\'{}s composition even when the chameleon coupling constants $\\beta_{i}$ are universal. In particular, we compared the resulting differential acceleration of test bodies made of Be and Al with the corresponding bounds obtained from E\\"otv\\"os type experiments and find that the predictions of the chameleon model are, in general, various orders of magnitude a...

  1. Equivalent Simplification Method of Micro-Grid

    Directory of Open Access Journals (Sweden)

    Cai Changchun

    2013-09-01

    Full Text Available The paper concentrates on the equivalent simplification method for the micro-grid system connection into distributed network. The equivalent simplification method proposed for interaction study between micro-grid and distributed network. Micro-grid network, composite load, gas turbine synchronous generation, wind generation are equivalent simplification and parallel connect into the point of common coupling. A micro-grid system is built and three phase and single phase grounded faults are performed for the test of the equivalent model of micro-grid. The simulation results show that the equivalent model of micro-grid is effective, and the dynamic of equivalent model is similar with the detailed model of micro-grid. The equivalent simplification method for the micro-grid network and distributed components is suitable for the study of micro-grid.  

  2. Broadband shifts in LFP power spectra are correlated with single-neuron spiking in humans

    Science.gov (United States)

    Manning, Jeremy R.; Jacobs, Joshua; Fried, Itzhak; Kahana, Michael J.

    2010-01-01

    A fundamental question in neuroscience concerns the relation between the spiking of individual neurons and the aggregate electrical activity of neuronal ensembles as seen in local-field potentials (LFPs). Because LFPs reflect both spiking activity and subthreshold events, this question is not simply one of data aggregation. Recording from 20 neurosurgical patients, we directly examined the relation between LFPs and neuronal spiking. Examining 2,030 neurons in widespread brain regions, we found that firing rates were positively correlated with broadband (2 – 150 Hz) shifts in the LFP power spectrum. In contrast, narrowband oscillations correlated both positively and negatively with firing rates at different recording sites. Broadband power shifts were a more-reliable predictor of neuronal spiking than narrowband power shifts. These findings suggest that broadband LFP power provides valuable information concerning neuronal activity beyond that contained in narrowband oscillations. PMID:19864573

  3. Muscle coordination limits efficiency and power output of human limb movement under a wide range of mechanical demands.

    Science.gov (United States)

    Blake, Ollie M; Wakeling, James M

    2015-12-01

    This study investigated the influence of cycle frequency and workload on muscle coordination and the ensuing relationship with mechanical efficiency and power output of human limb movement. Eleven trained cyclists completed an array of cycle frequency (cadence)-power output conditions while excitation from 10 leg muscles and power output were recorded. Mechanical efficiency was maximized at increasing cadences for increasing power outputs and corresponded to muscle coordination and muscle fiber type recruitment that minimized both the total muscle excitation across all muscles and the ineffective pedal forces. Also, maximum efficiency was characterized by muscle coordination at the top and bottom of the pedal cycle and progressive excitation through the uniarticulate knee, hip, and ankle muscles. Inefficiencies were characterized by excessive excitation of biarticulate muscles and larger duty cycles. Power output and efficiency were limited by the duration of muscle excitation beyond a critical cadence (120-140 rpm), with larger duty cycles and disproportionate increases in muscle excitation suggesting deteriorating muscle coordination and limitations of the activation-deactivation capabilities. Most muscles displayed systematic phase shifts of the muscle excitation relative to the pedal cycle that were dependent on cadence and, to a lesser extent, power output. Phase shifts were different for each muscle, thereby altering their mechanical contribution to the pedaling action. This study shows that muscle coordination is a key determinant of mechanical efficiency and power output of limb movement across a wide range of mechanical demands and that the excitation and coordination of the muscles is limited at very high cycle frequencies. Copyright © 2015 the American Physiological Society.

  4. A formal design verification and validation on the human factors of a computerized information system in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee; Park, Jae Chang; Cheon, Se Woo; Jung, Kwang Tae; Baek, Seung Min; Han, Seung; Park, Hee Suk; Son, Ki Chang; Kim, Jung Man; Jung Yung Woo

    1999-11-01

    This report describe a technical transfer under the title of ''A formal design verification and validation on the human factors of a computerized information system in nuclear power plants''. Human factors requirements for the information system designs are extracted from various regulatory and industrial standards and guidelines, and interpreted into a more specific procedures and checklists for verifying the satisfaction of those requirements. A formalized implementation plan is established for human factors verification and validation of a computerized information system in nuclear power plants. Additionally, a Computer support system, named as DIMS-web (design Issue Management System), is developed based upon web internet environment so as to enhance the implementation of the human factors activities. DIMS-Web has three maine functions: supporting requirements review, tracking design issues, and management if issues screening evaluation. DIMS-Web shows its benefits in practice through a trial application to the design review of CFMS for YGN nuclear unit 5 and 6. (author)

  5. Stretch-induced enhancement of mechanical power output in human multijoint exercise with countermovement.

    Science.gov (United States)

    Takarada, Y; Hirano, Y; Ishige, Y; Ishii, N

    1997-11-01

    The relation between the eccentric force developed during a countermovement and the mechanical power output was studied in squatting exercises under nominally isotonic load (50% of 1-repetition maximum). The subjects (n = 5) performed squatting exercises with a countermovement at varied deceleration rates before lifting the load. The ground reaction force and video images were recorded to obtain the power output of the body. Net muscle moments acting at hip, knee, and ankle joints were calculated from video recordings by using inverse dynamics. When an intense deceleration was taken at the end of downward movement, large eccentric force was developed, and the mechanical power subsequently produced during the lifting movement was consistently larger than that produced without the countermovement. Both maximal and mean power outputs during concentric actions increased initially with the eccentric force, whereas they began to decline when the eccentric force exceeded approximately 1.4 times the sum of load and body weight. Video-image analysis showed that this characteristic relation was predominantly determined by the torque around the knee joint. Electromyographic analyses showed no consistent increase in time-averaged integrated electromyograph from vastus lateralis with the power output, suggesting that the enhancement of power output is primarily caused by the prestretch-induced improvement of an intrinsic force-generating capability of the agonist muscle.

  6. Low statistical power in biomedical science: a review of three human research domains

    Science.gov (United States)

    Dumas-Mallet, Estelle; Button, Katherine S.; Boraud, Thomas; Gonon, Francois

    2017-01-01

    Studies with low statistical power increase the likelihood that a statistically significant finding represents a false positive result. We conducted a review of meta-analyses of studies investigating the association of biological, environmental or cognitive parameters with neurological, psychiatric and somatic diseases, excluding treatment studies, in order to estimate the average statistical power across these domains. Taking the effect size indicated by a meta-analysis as the best estimate of the likely true effect size, and assuming a threshold for declaring statistical significance of 5%, we found that approximately 50% of studies have statistical power in the 0–10% or 11–20% range, well below the minimum of 80% that is often considered conventional. Studies with low statistical power appear to be common in the biomedical sciences, at least in the specific subject areas captured by our search strategy. However, we also observe evidence that this depends in part on research methodology, with candidate gene studies showing very low average power and studies using cognitive/behavioural measures showing high average power. This warrants further investigation. PMID:28386409

  7. Power for genetic association study of human longevity using the case-control design.

    Science.gov (United States)

    Tan, Qihua; Zhao, Jing Hua; Zhang, Dongfeng; Kruse, Torben A; Christensen, Kaare

    2008-10-15

    The efficiency of the popular case-control design in gene-longevity association studies needs to be verified because, different from a binary trait, longevity represents only the extreme end of the continuous life span distribution without a clear cutoff for defining the phenotype. In this paper, the authors use the current Danish life tables to simulate individual life span by using a variety of scenarios and assess the empirical power for different sample sizes when cases are defined as centenarians or as nonagenarians. Results show that, although using small samples of centenarians (several hundred) provides power to detect only common alleles with large effects (a >20% reduction in hazard rate), large samples of centenarians (>1,000) achieve power to capture genes responsible for minor effects (5%-10% hazard reduction depending on the mode of inheritance). Although the method provides good power for rare alleles with multiplicative or dominant effects, it performs poorly for rare recessive alleles. Power is drastically reduced when nonagenarians are considered cases, with a more than 5-fold difference in the size of the case sample required to achieve comparable power as that found with centenarians.

  8. Menace and Management: Power in the Human-Monkey Social Worlds of Delhi and Shimla

    OpenAIRE

    Solomon, Daniel Allen

    2013-01-01

    This dissertation is based on ethnographic and textual research among the monkeys and humans of two Indian metropolises, mostly between 2006-2010. The monkeys are rhesus macaques, who have lived alongside humans in South Asia for thousands of years, make their livings in apparently anthropogenic material-symbolic environments. Rhesus participate in the shaping of the space of their interaction with humans; that is, they engage in multispecies world-building. In the context of their relationsh...

  9. Quantitative comparisons of genotoxic effects of atomic energy and fossil-fuelled energy. Rad-equivalences for ethylene, ethylene oxide and formaldehyde - consequences for decisions at Government level

    Energy Technology Data Exchange (ETDEWEB)

    Latarjet, R.; Averbeck, D.; Levy, S.; Poirier, V. (Section de Biologie, Institut Curie, Paris, France)

    1982-01-01

    Rad-equivalences have been determined on the basis of data on the genotoxic effects of low linear energy transfer ionizing radiation and of three chemical pollutants - ethylene, ethylene oxide and formaldehyde - emitted from energy-producing power plants. In the case of ethylene and its metabolite, ethylene oxide, the conditions were particularly favourable because the equivalences could be based on the induction of total mutations in the mouse, which is the same genetic end-point used for the assessment of radiation risks. Once established, the rad-equivalences were used (a) to extrapolate the rules adopted for radiation to each of these two compounds and (b) to make recommendations for exposed workers at 'hot spots' and for the general population. Measurements of ethylene in power plants and in the atmosphere of Paris have indicated that in most cases the measured values fall within the recommended values. However, pollution by ethylene oxide in cold sterilization units should be reduced. Rad-equivalences obtained for lethal effects, and for the induction of chromosome aberrations by formaldehyde in human cells in vitro, suggest that the maximum admissible concentrations are far too high in most countries and must be reconsidered. In France, the Ministry of Health is taking the rad-equivalences into consideration for the preparation of a law regulating pollution by ethylene and ethylene oxide - as a first step. These results show that rad-equivalences can be used for risk assessments of genotoxic effects from power plants and that decisions can be made by extrapolating the rules adopted for radiation protection to some chemical mutagens, when certain strict conditions are fulfilled.

  10. Japan and Human Security: A Powerful Discourse or a Useful Coping Mechanism?

    Directory of Open Access Journals (Sweden)

    CLAUSEN, Daniel

    2009-10-01

    Full Text Available The concept of human security has been gaining increasing currency in discussions over global security. Japan is considered a major contributor to both the intellectual mainstreaming of the concept and the implementation of human security through its financial support to the United Nations Trust Fund for Human Security, the establishment of the Commission on Human Security, and revision of its Official Development Assistance (ODA charter to meet human security guidelines. Japan’s pursuit of human security, as well as the status the concept enjoys among policy-makers and academics has led some to describe human security within Japan as a discourse. However, the literature remains ambivalent as to whether human security is a Discourse in the sense that it is hegemonic in the kinds of policy and policy thinking that it allows, or merely an instrumental discourse deployed in the service of Japanese foreign policy. This essay argues that human security should be seen as an instrumental discourse, currently used by the Ministry of Foreign Affairs (MOFA and the Japan International Cooperation Agency (JICA, to help pursue a greater international contribution without aggravating lingering controversies over Japanese militarism, but also, without directly rejecting a future move toward military normalization.

  11. Metabolic equivalents during scooter exercise.

    Science.gov (United States)

    Kijima, Akira; Arimoto, Morio; Muramatsu, Shigeru

    2007-06-01

    The purpose of this study was to determine the metabolic equivalents (METs) for scooter exercise (riding a scooter, scootering) and to examine the energy expenditure and the heart rate response, so that the results can be used in health promotion activities. Eighteen young adults (10 males and 8 females) participated in scootering on a treadmill at three different speeds for six minutes each. Before, during, and after the exercise, pulmonary ventilation, oxygen uptake (VO(2)), carbon dioxide product, respiratory exchange ratio (R), and heart rate (HR) were measured. These measurements kept steady states from the 3rd to 6th minute of each different speed session. The MET values acquired during scootering at 80 m.min(-1), 110 m.min(-1), and 140 m.min(-1) were 3.9, 4.3, and 5.0, respectively. Calculated using VO(2) (ml.kg(-1).min(-1))x[4.0+R], the energy consumption for scootering at each speed was 67.0+/-10.6, 73.3+/-10.2, and 84.8+/-7.9 cal.kg(-1).min(-1), respectively. The regression equation between scootering speed (X, m.min(-1)) and VO(2) (Y, ml.kg(-1).min(-1)) is Y=0.062X+8.655, and the regression equation between HR (X, beats.min(-1)) and VO(2)reserve (Y, %) is Y=0.458X-11.264. These equations can be applied to both females and males. Thus, scootering at 80 to 140 m.min(-1) might not be sufficient to improve the cardiorespiratory fitness of young male adults similar to the participants, but it may contribute many healthy benefits to most female adults and even male adults, and improve their health and fitness at the faster speeds.

  12. On the averaging area for incident power density for human exposure limits at frequencies over 6 GHz

    Science.gov (United States)

    Hashimoto, Yota; Hirata, Akimasa; Morimoto, Ryota; Aonuma, Shinta; Laakso, Ilkka; Jokela, Kari; Foster, Kenneth R.

    2017-04-01

    Incident power density is used as the dosimetric quantity to specify the restrictions on human exposure to electromagnetic fields at frequencies above 3 or 10 GHz in order to prevent excessive temperature elevation at the body surface. However, international standards and guidelines have different definitions for the size of the area over which the power density should be averaged. This study reports computational evaluation of the relationship between the size of the area over which incident power density is averaged and the local peak temperature elevation in a multi-layer model simulating a human body. Three wave sources are considered in the frequency range from 3 to 300 GHz: an ideal beam, a half-wave dipole antenna, and an antenna array. 1D analysis shows that averaging area of 20 mm  ×  20 mm is a good measure to correlate with the local peak temperature elevation when the field distribution is nearly uniform in that area. The averaging area is different from recommendations in the current international standards/guidelines, and not dependent on the frequency. For a non-uniform field distribution, such as a beam with small diameter, the incident power density should be compensated by multiplying a factor that can be derived from the ratio of the effective beam area to the averaging area. The findings in the present study suggest that the relationship obtained using the 1D approximation is applicable for deriving the relationship between the incident power density and the local temperature elevation.

  13. Genetic variability in the human cannabinoid receptor 1 is associated with resting state EEG theta power in humans

    NARCIS (Netherlands)

    Heitland, I.; Kenemans, J. L.; Böcker, K. B E; Baas, J. M P

    2014-01-01

    It has long been postulated that exogenous cannabinoids have a profound effect on human cognitive functioning. These cannabinoid effects are thought to depend, at least in parts, on alterations of phase-locking of local field potential neuronal firing. The latter can be measured as activity in the t

  14. Human skin based triboelectric nanogenerators for harvesting biomechanical energy and as self-powered active tactile sensor system.

    Science.gov (United States)

    Yang, Ya; Zhang, Hulin; Lin, Zong-Hong; Zhou, Yu Sheng; Jing, Qingshen; Su, Yuanjie; Yang, Jin; Chen, Jun; Hu, Chenguo; Wang, Zhong Lin

    2013-10-22

    We report human skin based triboelectric nanogenerators (TENG) that can either harvest biomechanical energy or be utilized as a self-powered tactile sensor system for touch pad technology. We constructed a TENG utilizing the contact/separation between an area of human skin and a polydimethylsiloxane (PDMS) film with a surface of micropyramid structures, which was attached to an ITO electrode that was grounded across a loading resistor. The fabricated TENG delivers an open-circuit voltage up to -1000 V, a short-circuit current density of 8 mA/m(2), and a power density of 500 mW/m(2) on a load of 100 MΩ, which can be used to directly drive tens of green light-emitting diodes. The working mechanism of the TENG is based on the charge transfer between the ITO electrode and ground via modulating the separation distance between the tribo-charged skin patch and PDMS film. Furthermore, the TENG has been used in designing an independently addressed matrix for tracking the location and pressure of human touch. The fabricated matrix has demonstrated its self-powered and high-resolution tactile sensing capabilities by recording the output voltage signals as a mapping figure, where the detection sensitivity of the pressure is about 0.29 ± 0.02 V/kPa and each pixel can have a size of 3 mm × 3 mm. The TENGs may have potential applications in human-machine interfacing, micro/nano-electromechanical systems, and touch pad technology.

  15. Conceptual and experimental approach to the vulnerability of human resources in the evolving structure of the national power system to 2030 period

    Energy Technology Data Exchange (ETDEWEB)

    Dan Gheorghiu, Ioan; Visa, Ion; Carabulea, Anatol; Morar, Adrian; Popper, Laurentiu; Popper, Gabriel; Bucur, Camelia

    2010-09-15

    We present the causes generating vulnerabilities and propose the models for diminishing the risks and catastrophes based on the education of the human resources incorporated in the evolution of the local power system and not only. We specify the fuzzy structure of the model for increasing the quality of the human factor and of the models for rating the human resources in power plants and the networks of the power systems exemplified on the evolving structure of the Romanian installations subject to dynamic reconfiguring over the forecast interval (2020 - 2035).

  16. Power assessment for genetic association study of human longevity using offspring of long-lived subjects.

    Science.gov (United States)

    Tan, Qihua; Zhao, Jing Hua; Li, Shuxia; Kruse, Torben A; Christensen, Kaare

    2010-07-01

    Recently, an indirect genetic association approach that compares genotype frequencies in offspring of long-lived subjects and offspring from random families has been introduced to study gene-longevity associations. Although the indirect genetic association has certain advantages over the direct association approach that compares genotype frequency between centenarians and young controls, the power has been of concern. This paper reports a power study performed on the indirect approach using computer simulation. We perform our simulation study by introducing the current Danish population life table and the proportional hazard model for generating individual lifespan. Family genotype data is generated using a genetic linkage program for given SNP allele frequency. Power is estimated by setting the type I error rate at 0.05 and by calculating the Armitage's chi-squared test statistic for 200 replicate samples for each setting of the specified allele risk and frequency parameters under different modes of inheritance and for different sample sizes. The indirect genetic association analysis is a valid approach for studying gene-longevity association, but the sample size requirement is about 3-4 time larger than the direct approach. It also has low power in detecting non-additive effect genes. Indirect genetic association using offspring from families with both parents as nonagenarians is nearly as powerful as using offspring from families with one centenarian parent. In conclusion, the indirect design can be a good choice for studying longevity in comparison with other alternatives, when relatively large sample size is available.

  17. Equivalence Principle and the Baryon Acoustic Peak

    CERN Document Server

    Baldauf, Tobias; Simonović, Marko; Zaldarriaga, Matias

    2015-01-01

    We study the dominant effect of a long wavelength density perturbation $\\delta(\\lambda_L)$ on short distance physics. In the non-relativistic limit, the result is a uniform acceleration, fixed by the equivalence principle, and typically has no effect on statistical averages due to translational invariance. This same reasoning has been formalized to obtain a "consistency condition" on the cosmological correlation functions. In the presence of a feature, such as the acoustic peak at $l_{\\rm BAO}$, this naive expectation breaks down for $\\lambda_Lpower spectrum. Finally, the success of BAO reconstruction schemes is argue...

  18. The Transformative Power of Democracy and Human Rights in Nonformal Education: The Case of Tostan

    Science.gov (United States)

    Gillespie, Diane; Melching, Molly

    2010-01-01

    This case study analyzes the introduction of democracy and human rights into the educational program of Tostan, a nongovernmental organization working in Africa. The authors show how Tostan's original educational approach created a meaningful context for integrating democracy and human rights into its curriculum, a process that took place from…

  19. Human factors review of CFMS displays for Ulchin Nuclear Power Unit 3 and 4

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee; Baek, Seung Min; Kim, Jung Taek; Park, Jae Chang; Lee, Jung Woon; Oh, In Suk; Lee, Joon Whan; Jung, Kwang Tae; Cha, Hye Young [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-11-01

    This report describes the human factors review of CFMS displays for Ulchin 3 and 4 by the following four subjects; At first, by reviewing issues regarding the design process of present CFMS, human factors engineering program plan (HFEPP) and human factors verification and validation plan Were proposed to accomplish the completeness of design word; Secondly, researches and developments were integrated into the review results at the point of suitability of CFMS design concept and basic function; For the third, availability and suitability were assessed according to human factors evaluation criteria on the CFMS display design, and overall effectiveness was also evaluated in parts; For the fourth, recommendations were made to human factors problems in accordance with their importance and an implementation plan was suggested for the resolution of problems. 54 refs., 34 tabs., 42 figs. (author)

  20. IS AN INTERNATIONAL CORPORATE HUMAN RIGHTS LIABILITY FRAMEWORK NEEDED? AN ECONOMIC POWER, BUSINESS AND HUMAN RIGHTS, AND AMERICAN EXTRATERRITORIAL JURISDICTION ANALYSIS

    Directory of Open Access Journals (Sweden)

    Carlos Arevalo

    2013-11-01

    Full Text Available All companies, regardless of the sector they belong to, can positively or negatively impact human rights. Governments are increasingly aware of the benefits that free trade brings their nations, which has led them to do whatever is necessary to attract foreign investment, even if it means to act against the interests of their own people. The power relationship between corporations and states generates a tension derived from their nature: while the objective of states is the welfare of its members, the purpose of corporations is profit. It is in the crack generated by the collision of powers and purposes between these two actors, that this article is intended to raise the discussion on the need to establish an international framework for corporate liability for human rights violations. To achieve its goal, the article will analyze the opportunities and obstacles raised by the exercise of extraterritorial jurisdiction in the American context and its relationship with the developments in the business and human rights field.

  1. Power assessment for genetic association study of human longevity using offspring of long-lived subjects

    DEFF Research Database (Denmark)

    Tan, Qihua; Zhao, Jing Hua; Li, Shuxia

    2010-01-01

    Recently, an indirect genetic association approach that compares genotype frequencies in offspring of long-lived subjects and offspring from random families has been introduced to study gene-longevity associations. Although the indirect genetic association has certain advantages over the direct...... association approach that compares genotype frequency between centenarians and young controls, the power has been of concern. This paper reports a power study performed on the indirect approach using computer simulation. We perform our simulation study by introducing the current Danish population life table...... and the proportional hazard model for generating individual lifespan. Family genotype data is generated using a genetic linkage program for given SNP allele frequency. Power is estimated by setting the type I error rate at 0.05 and by calculating the Armitage's chi-squared test statistic for 200 replicate samples...

  2. INVARIANTS UNDER STABLE EQUIVALENCES OF MORITA TYPE

    Institute of Scientific and Technical Information of China (English)

    Li Fang; Sun Longgang

    2012-01-01

    The aim of this article is to study some invariants of associative algebras under stable equivalences of Morita type.First of all,we show that,if two finite-dimensional selfinjective k-algebras are stably equivalent of Morita type,then their orbit algebras are isomorphic.Secondly,it is verified that the quasitilted property of an algebra is invariant under stable equivalences of Morita type.As an application of this result,it is obtained that if an algebra is of finite representation type,then its tilted property is invariant under stable equivalences of Morita type; the other application to partial tilting modules is given in Section 4. Finally,we prove that when two finite-dimensional k-algebras are stably equivalent of Morita type,their repetitive algebras are also stably equivalent of Morita type under certain conditions.

  3. Diminished acquired equivalence yet good discrimination performance in older participants

    Directory of Open Access Journals (Sweden)

    Jasper eRobinson

    2013-10-01

    Full Text Available We asked younger and older human participants to perform computer-based configural discriminations that were designed to detect acquired equivalence. Both groups solved the discriminations but only the younger participants demonstrated acquired equivalence. The discriminations involved learning the preferences (‘like’ [+] or ‘dislike’ [-] for sports (e.g., tennis [t] and hockey [h] of four fictitious people (e.g., Alice [A], Beth [B], Charlotte [C] & Dorothy [D]. In one experiment, the discrimination had the form: At+, Bt-, Ct+, Dt-, Ah-, Bh+, Ch-, Dh+. Notice that, e.g., Alice and Charlotte are ‘equivalent’ in liking tennis but disliking hockey. Acquired equivalence was assessed in ancillary components of the discrimination (e.g., by looking at the subsequent rate of ‘whole’ versus ‘partial’ reversal learning. Acquired equivalence is anticipated by a network whose hidden units are shared when inputs (e.g., A and C signal the same outcome (e.g., + when accompanied by the same input (t. One interpretation of these results is that there are age-related differences in the mechanisms of configural acquired equivalence.

  4. The Complexity of Identifying Large Equivalence Classes

    DEFF Research Database (Denmark)

    Skyum, Sven; Frandsen, Gudmund Skovbjerg; Miltersen, Peter Bro

    1999-01-01

    We prove that at least 3k−4/k(2k−3)(n/2) – O(k)equivalence tests and no more than 2/k (n/2) + O(n) equivalence tests are needed in the worst case to identify the equivalence classes with at least k members in set of n elements. The upper bound is an improvement by a factor 2 compared to known res...

  5. Homogeneous Dielectric Equivalents of Composite Material Shields

    Directory of Open Access Journals (Sweden)

    P. Tobola

    2009-04-01

    Full Text Available The paper deals with the methodology of replacing complicated parts of an airplane skin by simple homogeneous equivalents, which can exhibit similar shielding efficiency. On one hand, the airplane built from the virtual homogeneous equivalents can be analyzed with significantly reduced CPU-time demands and memory requirements. On the other hand, the equivalent model can estimate the internal fields satisfactory enough to evaluate the electromagnetic immunity of the airplane.

  6. Equivalent Simplification Method of Micro-Grid

    OpenAIRE

    Cai Changchun; Cao Xiangqin

    2013-01-01

    The paper concentrates on the equivalent simplification method for the micro-grid system connection into distributed network. The equivalent simplification method proposed for interaction study between micro-grid and distributed network. Micro-grid network, composite load, gas turbine synchronous generation, wind generation are equivalent simplification and parallel connect into the point of common coupling. A micro-grid system is built and three phase and single phase grounded faults are per...

  7. equivalency/majorly/market share,etc.

    Institute of Scientific and Technical Information of China (English)

    张福基

    1998-01-01

    equivalency n. a level of achievement equivalent to completion of an educational or trainingprogram。同等学历(相当于完成某一教育或训练计划的学业成绩水平):a highschool equivalency certificate中学同等学历证书。注意不能用equivalence。majorly[’meid??li]adv.[1956

  8. Penelope simulation of electron beams 6 MeV from a linear accelerator for studies in different materials equivalent to human body; Simulacion Penelope de haces de electrones de 6 MeV de un acelerador lineal para estudios en diferentes materiales equivalentes al cuerpo humano

    Energy Technology Data Exchange (ETDEWEB)

    Apaza V, D.; Cardena R, R.; Cayllahua Q, F.; Vega R, J. [Universidad Nacional de San Agustin de Arequipa, Av. Independencia s/n, Hexagonos de Fisica, Arequipa (Peru); Urquizo B, R., E-mail: dgav02@gmail.com [Hospital Nacional Carlos Alberto Seguin Escobedo, Esquina de Peral y Filtro s/n, Arequipa (Peru)

    2015-10-15

    In systems of radiotherapy treatment for cancer, always looking to maximize the radiation dose on the target (tumor) and minimize to the organs at risk or healthy, so they resort to using electron beams that have properties and characteristics of higher dose deposition at fixed depths, directing and focusing the higher dose in the tumor, without harming healthy tissues to which seeks to radiate in the least possible. Simulating the interaction of electron beams with different equivalent tissues to the human body leads to a better dosimetric evaluation, improving the quality of treatment planning. The aim of this study is the comparison from the characterization of several equivalent tissues to the human body such as soft tissue, bone and lung. Based on the simulation of a calibration beam in water phantom with Penelope code and compared with the results of the calibration curves of beams in water vat by a linear accelerator Elekta Synergy of Hospital Nacional Carlos Alberto Seguin Escobedo EsSalud of Arequipa (Peru). From this to evaluate the behavior of electron beams in a homogeneous medium and then further evaluation in the human body homogeneities, for better evaluation and specific treatment planning. (Author)

  9. 21 CFR 26.6 - Equivalence assessment.

    Science.gov (United States)

    2010-04-01

    ... OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS... Specific Sector Provisions for Pharmaceutical Good Manufacturing Practices § 26.6 Equivalence...

  10. Approximate equivalence in von Neumann algebras

    Institute of Scientific and Technical Information of China (English)

    DING; Huiru; Don; Hadwin

    2005-01-01

    One formulation of D. Voiculescu's theorem on approximate unitary equivalence is that two unital representations π and ρ of a separable C*-algebra are approximately unitarily equivalent if and only if rank o π = rank o ρ. We study the analog when the ranges of π and ρ are contained in a von Neumann algebra R, the unitaries inducing the approximate equivalence must come from R, and "rank" is replaced with "R-rank" (defined as the Murray-von Neumann equivalence of the range projection).

  11. A human error analysis methodology, AGAPE-ET, for emergency tasks in nuclear power plants and its application

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Whan; Jung, Won Dea [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-03-01

    This report presents a procedurised human reliability analysis (HRA) methodology, AGAPE-ET (A Guidance And Procedure for Human Error Analysis for Emergency Tasks), for both qualitative error analysis and quantification of human error probability (HEP) of emergency tasks in nuclear power plants. The AGAPE-ET is based on the simplified cognitive model. By each cognitive function, error causes or error-likely situations have been identified considering the characteristics of the performance of each cognitive function and influencing mechanism of PIFs on the cognitive function. Then, error analysis items have been determined from the identified error causes or error-likely situations to help the analysts cue or guide overall human error analysis. A human error analysis procedure based on the error analysis items is organised. The basic scheme for the quantification of HEP consists in the multiplication of the BHEP assigned by the error analysis item and the weight from the influencing factors decision tree (IFDT) constituted by cognitive function. The method can be characterised by the structured identification of the weak points of the task required to perform and the efficient analysis process that the analysts have only to carry out with the necessary cognitive functions. The report also presents the the application of AFAPE-ET to 31 nuclear emergency tasks and its results. 42 refs., 7 figs., 36 tabs. (Author)

  12. Determination of the Optimized Automation Rate considering Effects of Automation on Human Operators in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Min; Seong, Poong Hyun [Korea Advanced Institute of Science and Technology, Daejon (Korea, Republic of); Kim, Jong Hyun [KEPCO International Nuclear Graduate School, Seosaeng (Korea, Republic of); Kim, Man Cheol [Chung-Ang University, Seoul (Korea, Republic of)

    2015-05-15

    Automation refers to the use of a device or a system to perform a function previously performed by a human operator. It is introduced to reduce the human errors and to enhance the performance in various industrial fields, including the nuclear industry. However, these positive effects are not always achieved in complex systems such as nuclear power plants (NPPs). An excessive introduction of automation can generate new roles for human operators and change activities in unexpected ways. As more automation systems are accepted, the ability of human operators to detect automation failures and resume manual control is diminished. This disadvantage of automation is called the Out-of-the- Loop (OOTL) problem. We should consider the positive and negative effects of automation at the same time to determine the appropriate level of the introduction of automation. Thus, in this paper, we suggest an estimation method to consider the positive and negative effects of automation at the same time to determine the appropriate introduction of automation. This concept is limited in that it does not consider the effects of automation on human operators. Thus, a new estimation method for automation rate was suggested to overcome this problem.

  13. New monoclonal antibodies directed against human renin. Powerful tools for the investigation of the renin system.

    OpenAIRE

    Galen, F X; Devaux, C.; Atlas, S; Guyenne, T; Menard, J; Corvol, P; Simon, D.; Cazaubon, C; Richer, P; Badouaille, G

    1984-01-01

    Monoclonal antibodies directed against human renin were obtained by the fusing of myeloma cells with spleen cells from Balb/c or high-responder Biozzi mice injected with pure tumoral or highly purified renal renin. These procedures resulted in the production of seven stable monoclonal antibodies to human renin. Antibodies in the hybridoma culture medium were screened by binding to pure iodinated renin or insolubilized renin in a solid phase assay. The concentration of purified antibodies that...

  14. TNT Equivalency of Unconfined Aerosols of Propylene Oxide

    Directory of Open Access Journals (Sweden)

    A. Apparao

    2014-09-01

    Full Text Available The unconfined aerosols of propylene oxide (PO are formed by dispersing the fuel in air. These aerosols undergo detonation by suitable initiation and produce high impulse blast. Tri-nitro Toluene (TNT equivalence is an important parameter used to represent the power of explosive materials and compare their relative damage effects wrt TNT. The parameters commonly used for estimation of TNT equivalency are total energy of explosive source and properties of resulting blast wave, viz., blast peak overpressure and positive impulse. In the present study, the unconfined aerosols of 4.2 kg PO were formed by breaking open the cylindrical canister with the help of axially positioned central burster charge and then detonated using a secondary explosive charge after a preset time delay. The resulting blast profiles were recorded and the blast parameters were analysed. Being a non-ideal explosive source, the TNT equivalency depends on fraction of total energy utilised for blast formation, the rate of energy release, cloud dimensions, and concentration of fuel. Hence, various approaches based on energy release, experimental blast profiles, triangulated blast parameters, and ground reflected blast parameters were considered to determine the TNT equivalency of unconfined PO aerosols. It was observed that the TNT equivalency is not a single value but vary with distance. The paper provides various options for weapon designer to choose a suitable approach for considering TNT equivalency. The scaling laws established from the experimental data of unconfined aerosols of PO for blast peak over pressure and scaled impulse help in predicting the performance for different values of fuel weight and distance.Defence Science Journal, Vol. 64, No. 5, September 2014, pp.431-437, DOI:http://dx.doi.org/10.14429/dsj.64.6851

  15. The human power amplifier technology at the University of California, Berkeley

    Science.gov (United States)

    Kazerooni, H.; Ellis, S. R. (Principal Investigator)

    1996-01-01

    A human's ability to perform physical tasks is limited by physical strength, not by intelligence. We define "extenders" as a class of robot manipulators worn by humans to augment human mechanical strength, while the wearer's intellect remains the central control system for manipulating the extender. Our research objective is to determine the ground rules for the design and control of robotic systems worn by humans through the design, construction, and control of several prototype experimental direct-drive/non-direct-drive multi-degree-of-freedom hydraulic/electric extenders. The design of extenders is different from the design of conventional robots because the extender interfaces with the human on a physical level. Two sets of force sensors measure the forces imposed on the extender by the human and by the environment (i.e., the load). The extender's compliances in response to such contact forces were designed by selecting appropriate force compensators. This paper gives a summary of some of the selected research efforts related to Extender Technology, carried out during 1980s. The references, at the end of this article, give detailed description of the research efforts.

  16. An industry analysis of the power of human capital for corporate performance: Evidence from South Africa

    Directory of Open Access Journals (Sweden)

    Carla Morris

    2015-11-01

    Full Text Available Even in industrialised emerging economies, the value-generating competencies of a workforce, known as its human capital efficiency, are a key resource for commercial success. The objective of this research is to empirically investigate the relationship between human capital efficiency (as measured by value-added human capital and the financial and market performance of companies listed on the Main Board and Alternative Exchange (ALT-X of the Johannesburg Stock Exchange. Return on assets, revenue growth and headline earnings per share were used as financial performance indicators; while market-to-book ratio and total share return were used to measure market performance. Multivariate regressions were performed, with panel data covering 390 companies in the financial, basic materials, consumer services, consumer goods, industrial and technology industries from 2001 to 2011. First, human capital efficiency was found to have no effect on the market performance of listed companies in South Africa. Secondly, higher human capital efficiency was found to result in the extraction of greater returns from both tangible and intangible assets in all industries. Thirdly, higher profitability was found to be associated with higher human capital efficiency in almost every industry in South Africa, with the exception of the technology industry, where human capital efficiency was found to be independent of headline earnings per share. Finally, higher revenue growth was found to be positively associated with human capital efficiency in those industries which are not consumer-driven. In the consumer-driven industries, human capital efficiency contributes to bottom line profitability even though it is not a driver for revenue growth. Overall, the results of this study confirm that human capital efficiency enhances a company’s financial performance, whether it be through a greater capacity for production and service delivery, tighter cost controls or better use of

  17. A novel dynamic equivalence method for grid-connected wind farm

    Institute of Scientific and Technical Information of China (English)

    Jia-geng QIAO; Zong-xiang LU; Yong MIN

    2008-01-01

    Dynamic equivalence of the wind farm is a fundamental problem in the simulation of a power system connected with wind farms because it is unpractical to model every generator in a wind farm in detail. In this paper, an Equivalence Method based on the Output Characteristics (EMOC) is proposed, with which the wind farm composed of Squirrel-Cage Induction Generators (SCIGs) can be equivalent to one generator. By considering the diversity of wind generators and special operating characteristics of a wind farm, the equivalent generator based on EMOC responds accurately in various faults. No matter whether the wind farm is integrated in grid or just programmed, EMOC can be used to acquire an accurate equivalent generator. Simulation of the dynamic equivalence of an SCIG wind farm validated the method.

  18. Uncertainty management in telecommunications uninterruptible power supply systems and on their network by utilizing human reasoning methodology

    Science.gov (United States)

    Suntio, Teuvo

    1992-01-01

    A study to find the essential and important matters which can effect the reliable uninterrupted operation of telecommunications power supply systems and to suggest an optimal uncertainty management scheme is reported. The main goal was to find simple and practical but effective methods on which the uncertainty management and the implementation of its tool can be based. Uncertainty management ensures that there is enough reserve energy and minimizes additional uncertainties. It turned out that an optimal solution can be obtained by means of intelligent supervision, control and alarm facilities by utilizing human reasoning methodology, and minimize-uncertainty principles.

  19. Mathematical Equivalence of Evolution and Design

    Directory of Open Access Journals (Sweden)

    Leonid Perlovsky

    2010-12-01

    Full Text Available "Every one who is seriously involved in the pursuit of science becomes convinced that a spirit is manifest in the laws of the Universe." This Einsteinian statement remains outside of science. Our current understanding of the mind mechanisms have come close to explaining spirituality from the scientific point of view. In this paper a theory is presented which is a mathematical breakthrough, overcoming decades of limitations in AI, pattern recognition, neural networks, and other attempts to model the brain-mind. Solutions to engineering problems are presented that have overcome previous difficulties in terms of computational complexity. These solutions result in orders of magnitude improvement in detection, prediction, tracking, fusion, and learning situations. The theory is also extended to higher cognitive functions. It models the knowledge instinct operating in the hierarchy of the human brain-mind. At the top are concepts unifying our entire knowledge; we perceive them as concepts of the meaning and purpose of our existence. This theory is formulated mathematically as dynamic and equivalently as teleological. Experimental results supporting the theory are discussed. The theory overcomes various difficulties, including reductionism, which, in the past, interfered with the acceptance of scientific explanations of the spiritual.

  20. Nuclear reaction measurements on tissue-equivalent materials and GEANT4 Monte Carlo simulations for hadrontherapy

    Science.gov (United States)

    De Napoli, M.; Romano, F.; D'Urso, D.; Licciardello, T.; Agodi, C.; Candiano, G.; Cappuzzello, F.; Cirrone, G. A. P.; Cuttone, G.; Musumarra, A.; Pandola, L.; Scuderi, V.

    2014-12-01

    When a carbon beam interacts with human tissues, many secondary fragments are produced into the tumor region and the surrounding healthy tissues. Therefore, in hadrontherapy precise dose calculations require Monte Carlo tools equipped with complex nuclear reaction models. To get realistic predictions, however, simulation codes must be validated against experimental results; the wider the dataset is, the more the models are finely tuned. Since no fragmentation data for tissue-equivalent materials at Fermi energies are available in literature, we measured secondary fragments produced by the interaction of a 55.6 MeV u-1 12C beam with thick muscle and cortical bone targets. Three reaction models used by the Geant4 Monte Carlo code, the Binary Light Ions Cascade, the Quantum Molecular Dynamic and the Liege Intranuclear Cascade, have been benchmarked against the collected data. In this work we present the experimental results and we discuss the predictive power of the above mentioned models.

  1. Hypothesis testing and power calculations for taxonomic-based human microbiome data.

    Directory of Open Access Journals (Sweden)

    Patricio S La Rosa

    Full Text Available This paper presents new biostatistical methods for the analysis of microbiome data based on a fully parametric approach using all the data. The Dirichlet-multinomial distribution allows the analyst to calculate power and sample sizes for experimental design, perform tests of hypotheses (e.g., compare microbiomes across groups, and to estimate parameters describing microbiome properties. The use of a fully parametric model for these data has the benefit over alternative non-parametric approaches such as bootstrapping and permutation testing, in that this model is able to retain more information contained in the data. This paper details the statistical approaches for several tests of hypothesis and power/sample size calculations, and applies them for illustration to taxonomic abundance distribution and rank abundance distribution data using HMP Jumpstart data on 24 subjects for saliva, subgingival, and supragingival samples. Software for running these analyses is available.

  2. Universal power-law scaling of water diffusion in human brain defines what we see with MRI

    CERN Document Server

    Veraart, Jelle; Novikov, Dmitry S

    2016-01-01

    Development of successful therapies for neurological disorders depends on our ability to diagnose and monitor the progression of underlying pathologies at the cellular level. Physics and physiology limit the resolution of human MRI to millimeters, three orders of magnitude coarser than the cell dimensions of microns. A promising way to access cellular structure is provided by diffusion-weighted MRI (dMRI), a modality which exploits the sensitivity of the MRI signal to micron-level Brownian motion of water molecules strongly hindered by cell walls. By analyzing diffusion of water molecules in human subjects, here we demonstrate that biophysical modeling has the potential to break the intrinsic MRI resolution limits. The observation of a universal power-law scaling of the dMRI signal identifies the contribution from water specifically confined inside narrow impermeable axons, validating the overarching assumption behind models of diffusion in neuronal tissue. This scaling behavior establishes dMRI as an in vivo...

  3. Human factors design, verification, and validation for two types of control room upgrades at a nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Boring, Laurids Ronald [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-10-01

    This paper describes the NUREG-0711 based human factors engineering (HFE) phases and associated elements required to support design, verification and validation (V&V), and implementation of a new plant process computer (PPC) and turbine control system (TCS) at a representative nuclear power plant. This paper reviews ways to take a human-system interface (HSI) specification and use it when migrating legacy PPC displays or designing displays with new functionality. These displays undergo iterative usability testing during the design phase and then undergo an integrated system validation (ISV) in a full scope control room training simulator. Following the successful demonstration of operator performance with the systems during the ISV, the new system is implemented at the plant, first in the training simulator and then in the main control room.

  4. Criteria equivalent to the Riemann Hypothesis

    Science.gov (United States)

    Cisło, J.; Wolf, M.

    2008-11-01

    We give a brief overview of a few criteria equivalent to the Riemann Hypothesis. Next we concentrate on the Riesz and Báez-Duarte criteria. We prove that they are equivalent and we provide some computer data to support them.

  5. EQUIVALENT MODELS IN COVARIANCE STRUCTURE-ANALYSIS

    NARCIS (Netherlands)

    LUIJBEN, TCW

    1991-01-01

    Defining equivalent models as those that reproduce the same set of covariance matrices, necessary and sufficient conditions are stated for the local equivalence of two expanded identified models M1 and M2 when fitting the more restricted model M0. Assuming several regularity conditions, the rank def

  6. Galeazzi-equivalent lesions in adolescence.

    Science.gov (United States)

    Kamano, Masayuki; Honda, Yoshinobu

    2002-07-01

    Two cases of a Galeazzi-equivalent lesion in adolescence are described. Accurate diagnosis of the epiphyseal injury of the distal ulna, rigid fixation of the distal radius, and stabilization of the distal radioulnar joint are keys in obtaining a good result in the treatment of Galeazzi-equivalent lesion in adolescence.

  7. Orientifold Planar Equivalence: The Chiral Condensate

    DEFF Research Database (Denmark)

    Armoni, Adi; Lucini, Biagio; Patella, Agostino

    2008-01-01

    The recently introduced orientifold planar equivalence is a promising tool for solving non-perturbative problems in QCD. One of the predictions of orientifold planar equivalence is that the chiral condensates of a theory with $N_f$ flavours of Dirac fermions in the symmetric (or antisymmetric...

  8. Flow equivalence and isotopy for subshifts

    DEFF Research Database (Denmark)

    Boyle, Mike; Carlsen, Toke Meier; Eilers, Søren

    2017-01-01

    We study basic properties of flow equivalence on one-dimensional compact metric spaces with a particular emphasis on isotopy in the group of (self-) flow equivalences on such a space. In particular, we show that such an orbit-preserving map is not always an isotopy, but that this always is the ca...

  9. The therapeutic equivalence of complex drugs

    NARCIS (Netherlands)

    Schellekens, H.; Klinger, E.; Muehlebach, S.; Brin, J-F.; Storm, G.; Crommelin, D.J.A.

    2011-01-01

    When the patent of a small molecule drug expires generics may be introduced. They are considered therapeutically equivalent once pharmaceutical equivalence (i.e. identical active substances) and bioequivalence (i.e. comparable pharmacokinetics) have been established in a cross-over volunteer study.

  10. Peer-review study of the draft handbook for human-reliability analysis with emphasis on nuclear-power-plant applications, NUREG/CR-1278

    Energy Technology Data Exchange (ETDEWEB)

    Brune, R. L.; Weinstein, M.; Fitzwater, M. E.

    1983-01-01

    This report describes a peer review of the draft Handbook for Human Reliability Analysis with Emphasis on Nuclear Power Plant Applications, NUREG/CR-1278. The purpose of the study was to determine to what extent peers agree with the human behavior models and estimates of human error probabilities (HEPs) contained in the Handbook. Twenty-nine human factors experts participated in the study. Twenty of the participants were Americans; nine were from other countries. The peers performed human reliability analyses of a variety of human performance scenarios describing operator activities in nuclear power plant settings. They also answered questionnaires pertaining to the contents and application of the Handbook. An analysis of peer solutions to the human reliability analysis problems and peer responses to the questionnaire was performed. Recommendations regarding the format and contents of the Handbook were developed from the study findings.

  11. Human Hand Motion Analysis and Synthesis of Optimal Power Grasps for a Robotic Hand

    Directory of Open Access Journals (Sweden)

    Francesca Cordella

    2014-03-01

    Full Text Available Biologically inspired robotic systems can find important applications in biomedical robotics, since studying and replicating human behaviour can provide new insights into motor recovery, functional substitution and human-robot interaction. The analysis of human hand motion is essential for collecting information about human hand movements useful for generalizing reaching and grasping actions on a robotic system. This paper focuses on the definition and extraction of quantitative indicators for describing optimal hand grasping postures and replicating them on an anthropomorphic robotic hand. A motion analysis has been carried out on six healthy human subjects performing a transverse volar grasp. The extracted indicators point to invariant grasping behaviours between the involved subjects, thus providing some constraints for identifying the optimal grasping configuration. Hence, an optimization algorithm based on the Nelder-Mead simplex method has been developed for determining the optimal grasp configuration of a robotic hand, grounded on the aforementioned constraints. It is characterized by a reduced computational cost. The grasp stability has been tested by introducing a quality index that satisfies the form-closure property. The grasping strategy has been validated by means of simulation tests and experimental trials on an arm-hand robotic system. The obtained results have shown the effectiveness of the extracted indicators to reduce the non-linear optimization problem complexity and lead to the synthesis of a grasping posture able to replicate the human behaviour while ensuring grasp stability. The experimental results have also highlighted the limitations of the adopted robotic platform (mainly due to the mechanical structure to achieve the optimal grasp configuration.

  12. A Discrete Equivalent of the Logistic Equation

    Directory of Open Access Journals (Sweden)

    Petropoulou EugeniaN

    2010-01-01

    Full Text Available A discrete equivalent and not analogue of the well-known logistic differential equation is proposed. This discrete equivalent logistic equation is of the Volterra convolution type, is obtained by use of a functional-analytic method, and is explicitly solved using the -transform method. The connection of the solution of the discrete equivalent logistic equation with the solution of the logistic differential equation is discussed. Also, some differences of the discrete equivalent logistic equation and the well-known discrete analogue of the logistic equation are mentioned. It is hoped that this discrete equivalent of the logistic equation could be a better choice for the modelling of various problems, where different versions of known discrete logistic equations are used until nowadays.

  13. Calabi-Yau completions and orbifold equivalences

    CERN Document Server

    Carqueville, Nils

    2015-01-01

    Calabi-Yau algebras are particularly symmetric differential graded algebras. There is a construction due to Keller called `Calabi-Yau completion' which produces a canonical Calabi-Yau algebra from any homologically smooth dg algebra. Homologically smooth dg algebras also form a 2-category to which the construction of `equivariant completion' can be applied. In this theory two objects are called `orbifold equivalent' if there is a 1-morphism with invertible quantum dimensions between them. Any such relation entails a whole family of equivalences between categories. We show that Calabi-Yau completion and equivariant completion are compatible. More precisely, we prove that any orbifold equivalence between two homologically smooth and proper dg algebras lifts to an orbifold equivalence between their Calabi-Yau completions. As a corollary we obtain orbifold equivalences between Ginzburg algebras of Dynkin quivers.

  14. Equivalence in Ventilation and Indoor Air Quality

    Energy Technology Data Exchange (ETDEWEB)

    Sherman, Max; Walker, Iain; Logue, Jennifer

    2011-08-01

    We ventilate buildings to provide acceptable indoor air quality (IAQ). Ventilation standards (such as American Society of Heating, Refrigerating, and Air-Conditioning Enginners [ASHRAE] Standard 62) specify minimum ventilation rates without taking into account the impact of those rates on IAQ. Innovative ventilation management is often a desirable element of reducing energy consumption or improving IAQ or comfort. Variable ventilation is one innovative strategy. To use variable ventilation in a way that meets standards, it is necessary to have a method for determining equivalence in terms of either ventilation or indoor air quality. This study develops methods to calculate either equivalent ventilation or equivalent IAQ. We demonstrate that equivalent ventilation can be used as the basis for dynamic ventilation control, reducing peak load and infiltration of outdoor contaminants. We also show that equivalent IAQ could allow some contaminants to exceed current standards if other contaminants are more stringently controlled.

  15. 45 CFR 162.1101 - Health care claims or equivalent encounter information transaction.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Health care claims or equivalent encounter information transaction. 162.1101 Section 162.1101 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Health Care Claims or Equivalent Encounter Information §...

  16. Applying Human-performance Models to Designing and Evaluating Nuclear Power Plants: Review Guidance and Technical Basis

    Energy Technology Data Exchange (ETDEWEB)

    O' Hara, J.M.

    2009-11-30

    Human performance models (HPMs) are simulations of human behavior with which we can predict human performance. Designers use them to support their human factors engineering (HFE) programs for a wide range of complex systems, including commercial nuclear power plants. Applicants to U.S. Nuclear Regulatory Commission (NRC) can use HPMs for design certifications, operating licenses, and license amendments. In the context of nuclear-plant safety, it is important to assure that HPMs are verified and validated, and their usage is consistent with their intended purpose. Using HPMs improperly may generate misleading or incorrect information, entailing safety concerns. The objective of this research was to develop guidance to support the NRC staff's reviews of an applicant's use of HPMs in an HFE program. The guidance is divided into three topical areas: (1) HPM Verification, (2) HPM Validation, and (3) User Interface Verification. Following this guidance will help ensure the benefits of HPMs are achieved in a technically sound, defensible manner. During the course of developing this guidance, I identified several issues that could not be addressed; they also are discussed.

  17. Social collective intelligence: combining the powers of humans and machines to build a smarter society

    NARCIS (Netherlands)

    Miorandi, Daniele; Maltese, Vincenzo; Rovatsos, Michael; Nijholt, Anton; Stewart, James

    2014-01-01

    The book focuses on Social Collective Intelligence, a term used to denote a class of socio-technical systems that combine, in a coordinated way, the strengths of humans, machines and collectives in terms of competences, knowledge and problem solving capabilities with the communication, computing and

  18. Social collective intelligence: combining the powers of humans and machines to build a smarter society

    NARCIS (Netherlands)

    Miorandi, Daniele; Maltese, Vincenzo; Rovatsos, Michael; Nijholt, Antinus; Stewart, James

    2014-01-01

    The book focuses on Social Collective Intelligence, a term used to denote a class of socio-technical systems that combine, in a coordinated way, the strengths of humans, machines and collectives in terms of competences, knowledge and problem solving capabilities with the communication, computing and

  19. Analysis of mobile phone design features affecting radiofrequency power absorbed in a human head phantom.

    Science.gov (United States)

    Kuehn, Sven; Kelsh, Michael A; Kuster, Niels; Sheppard, Asher R; Shum, Mona

    2013-09-01

    The US FCC mandates the testing of all mobile phones to demonstrate compliance with the rule requiring that the peak spatial SAR does not exceed the limit of 1.6 W/kg averaged over any 1 g of tissue. These test data, measured in phantoms with mobile phones operating at maximum antenna input power, permitted us to evaluate the variation in SARs across mobile phone design factors such as shape and antenna design, communication technology, and test date (over a 7-year period). Descriptive statistical summaries calculated for 850 MHz and 1900 MHz phones and ANOVA were used to evaluate the influence of the foregoing factors on SARs. Service technology accounted for the greatest variability in compliance test SARs that ranged from AMPS (highest) to CDMA, iDEN, TDMA, and GSM (lowest). However, the dominant factor for SARs during use is the time-averaged antenna input power, which may be much less than the maximum power used in testing. This factor is largely defined by the communication system; e.g., the GSM phone average output can be higher than CDMA by a factor of 100. Phone shape, antenna type, and orientation of a phone were found to be significant but only on the order of up to a factor of 2 (3 dB). The SAR in the tilt position was significantly smaller than for touch. The side of the head did not affect SAR levels significantly. Among the remaining factors, external antennae produced greater SARs than internal ones, and brick and clamshell phones produced greater SARs than slide phones. Assuming phone design and usage patterns do not change significantly over time, we have developed a normalization procedure and formula that permits reliable prediction of the relative SAR between various communication systems. This approach can be applied to improve exposure assessment in epidemiological research.

  20. Planckian Power Spectral Densities from Human Calves during Posture Maintenance and Controlled Isometric Contractions.

    Directory of Open Access Journals (Sweden)

    J E Lugo

    Full Text Available The relationship between muscle anatomy and physiology and its corresponding electromyography activity (EMGA is complex and not well understood. EMGA models may be broadly divided in stochastic and motor-unit-based models. For example, these models have successfully described many muscle physiological variables such as the value of the muscle fiber velocity and the linear relationship between median frequency and muscle fiber velocity. However they cannot explain the behavior of many of these variables with changes in intramuscular temperature, or muscle PH acidity, for instance. Here, we propose that the motor unit action potential can be treated as an electromagnetic resonant mode confined at thermal equilibrium inside the muscle. The motor units comprising the muscle form a system of standing waves or modes, where the energy of each mode is proportional to its frequency. Therefore, the power spectral density of the EMGA is well described and fit by Planck's law and from its distribution we developed theoretical relationships that explain the behavior of known physiological variables with changes in intramuscular temperature or muscle PH acidity, for instance.EMGA of the calf muscle was recorded during posture maintenance in seven participants and during controlled isometric contractions in two participants. The power spectral density of the EMGA was then fit with the Planckian distribution. Then, we inferred nine theoretical relationships from the distribution and compared the theoretically derived values with experimentally obtained values.The power spectral density of EMGA was fit by Planckian distributions and all the theoretical relationships were validated by experimental results.Only by considering the motor unit action potentials as electromagnetic resonant modes confined at thermal equilibrium inside the muscle suffices to predict known or new theoretical relationships for muscle physiological variables that other models have failed

  1. Maintenance supply chain for nuclear power plants : information technology support for human resources management

    OpenAIRE

    Androjna, Andrej; Bizjak, Robert; Rosi, Bojan

    2012-01-01

    The paper is looking at a case on IT support of HR management in a maintenance supply chain for nuclear power plants and analyzing a specific solution developed by NUMIP Ltd. The database NOS Data developed by NUMIP Ltd.has proved to be an efficient tool for the intended purpose and size of the current application. Yet there is a clear potential for improvement of the tool in the future, mainly related to direct electronic data exchange with customers and subcontractors, as well as to impleme...

  2. 78 FR 67360 - Ambient Air Monitoring Reference and Equivalent Methods: Designation of Five New Equivalent Methods

    Science.gov (United States)

    2013-11-12

    ... AGENCY Ambient Air Monitoring Reference and Equivalent Methods: Designation of Five New Equivalent... of the designation of five new equivalent methods for monitoring ambient air quality. SUMMARY: Notice... measuring concentrations of PM 10-2.5 , two for measuring PM 2.5, and one for measuring NO 2 in the...

  3. On Equivalence and Non-equivalence of Words and Phrases In Different Cultures

    Institute of Scientific and Technical Information of China (English)

    高新霞

    2008-01-01

    This paper is mainly focused on the study of the relationship among three concepts, namely, culture,psychological association and equivalence or non-equivalence of words and phrases with combination of Problems posed by my students and discuss three patterns of the relationship with an attempt to describe the importance of culture to equivalence.

  4. Power-law scaling for macroscopic entropy and microscopic complexity: Evidence from human movement and posture

    Science.gov (United States)

    Hong, S. Lee; Bodfish, James W.; Newell, Karl M.

    2006-03-01

    We investigated the relationship between macroscopic entropy and microscopic complexity of the dynamics of body rocking and sitting still across adults with stereotyped movement disorder and mental retardation (profound and severe) against controls matched for age, height, and weight. This analysis was performed through the examination of center of pressure (COP) motion on the mediolateral (side-to-side) and anteroposterior (fore-aft) dimensions and the entropy of the relative phase between the two dimensions of motion. Intentional body rocking and stereotypical body rocking possessed similar slopes for their respective frequency spectra, but differences were revealed during maintenance of sitting postures. The dynamics of sitting in the control group produced lower spectral slopes and higher complexity (approximate entropy). In the controls, the higher complexity found on each dimension of motion was related to a weaker coupling between dimensions. Information entropy of the relative phase between the two dimensions of COP motion and irregularity (complexity) of their respective motions fitted a power-law function, revealing a relationship between macroscopic entropy and microscopic complexity across both groups and behaviors. This power-law relation affords the postulation that the organization of movement and posture dynamics occurs as a fractal process.

  5. Analytical and numerical construction of equivalent cables.

    Science.gov (United States)

    Lindsay, K A; Rosenberg, J R; Tucker, G

    2003-08-01

    The mathematical complexity experienced when applying cable theory to arbitrarily branched dendrites has lead to the development of a simple representation of any branched dendrite called the equivalent cable. The equivalent cable is an unbranched model of a dendrite and a one-to-one mapping of potentials and currents on the branched model to those on the unbranched model, and vice versa. The piecewise uniform cable, with a symmetrised tri-diagonal system matrix, is shown to represent the canonical form for an equivalent cable. Through a novel application of the Laplace transform it is demonstrated that an arbitrary branched model of a dendrite can be transformed to the canonical form of an equivalent cable. The characteristic properties of the equivalent cable are extracted from the matrix for the transformed branched model. The one-to-one mapping follows automatically from the construction of the equivalent cable. The equivalent cable is used to provide a new procedure for characterising the location of synaptic contacts on spinal interneurons.

  6. Bones and humanity. On Forensic Anthropology and its constitutive power facing forced disappearance

    Directory of Open Access Journals (Sweden)

    Anne Huffschmid

    2015-11-01

    Full Text Available Forensic anthropologists seek to decipher traces of anonymous dead, to restitute identities of human remains and to provide their families with the possibility to conclude mourning and even of justice. The article explores the contributions and meanings of forensic anthropology as state-independent practice beyond a mereley criminalistic approach, as it was conceptualized by the Argentine pioneers after the last dictatorship in this nation. I conceive this practice as a sort of arqueology of contemporary terror that seeks to confront a specific violence as the forced disappearance of persons and the deshumanization of their dead bodies. The article proposes reading forensic anthropology as a 'situated cience', with its complexities and ambigueties, that operates between nameless bones (the human remains and names without bodies (the so-called disappeared in settings of violent pasts such as Argentina or Guatemala, and especially in Mexico, where mass graves became the new symbol of a horrified present.

  7. Human Hand Motion Analysis and Synthesis of Optimal Power Grasps for a Robotic Hand

    Directory of Open Access Journals (Sweden)

    Francesca Cordella

    2014-03-01

    and experimental trials on an arm-hand robotic system. The obtained results have shown the effectiveness of the extracted indicators to reduce the non-linear optimization problem complexity and lead to the synthesis of a grasping posture able to replicate the human behaviour while ensuring grasp stability. The experimental results have also highlighted the limitations of the adopted robotic platform (mainly due to the mechanical structure to achieve the optimal grasp configuration.

  8. Task analysis and computer aid development for human reliability analysis in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, W. C.; Kim, H.; Park, H. S.; Choi, H. H.; Moon, J. M.; Heo, J. Y.; Ham, D. H.; Lee, K. K.; Han, B. T. [Korea Advanced Institute of Science and Technology, Taejeon (Korea)

    2001-04-01

    Importance of human reliability analysis (HRA) that predicts the error's occurrence possibility in a quantitative and qualitative manners is gradually increased by human errors' effects on the system's safety. HRA needs a task analysis as a virtue step, but extant task analysis techniques have the problem that a collection of information about the situation, which the human error occurs, depends entirely on HRA analyzers. The problem makes results of the task analysis inconsistent and unreliable. To complement such problem, KAERI developed the structural information analysis (SIA) that helps to analyze task's structure and situations systematically. In this study, the SIA method was evaluated by HRA experts, and a prototype computerized supporting system named CASIA (Computer Aid for SIA) was developed for the purpose of supporting to perform HRA using the SIA method. Additionally, through applying the SIA method to emergency operating procedures, we derived generic task types used in emergency and accumulated the analysis results in the database of the CASIA. The CASIA is expected to help HRA analyzers perform the analysis more easily and consistently. If more analyses will be performed and more data will be accumulated to the CASIA's database, HRA analyzers can share freely and spread smoothly his or her analysis experiences, and there by the quality of the HRA analysis will be improved. 35 refs., 38 figs., 25 tabs. (Author)

  9. Building human capital to increase earning power among people living with mental illnesses.

    Science.gov (United States)

    Gao, Ni; Schmidt, Lisa T; Gill, Kenneth J; Pratt, Carlos W

    2011-01-01

    Human Capital Theory, a well-established model from the field of economics, maintains that a person's lifetime earnings are affected by the amount of education and job training they receive. This study uses Human Capital Theory to predict wages and explain employment outcomes among individuals living with psychiatric illnesses. Hourly wages were examined between 100 individuals with mental illnesses and 100 matched comparisons who had no mental illnesses. The study found that participants with mental illnesses earned $12.19 an hour vs. $14.54 an hour earned by their counterparts without disability. The study also revealed that higher educational attainment and longer work history predicted higher wages among participants with mental illnesses. The severity of psychiatric symptoms and diagnosis, however, did not predict wages. These findings indicate that human capital variables are correlated with wages earned by persons living with mental illnesses. Findings also suggest that assisting mental health consumers in the pursuit of education and job training may increase earning potential which can lead to financial independence and community integration. This supports the value in developing and implementing Supported Education to assist consumers in acquiring education and job training.

  10. Adiabatic Quantum Computation is Equivalent to Standard Quantum Computation

    CERN Document Server

    Aharonov, D; Kempe, J; Landau, Z; Lloyd, S; Regev, O; Aharonov, Dorit; Dam, Wim van; Kempe, Julia; Landau, Zeph; Lloyd, Seth; Regev, Oded

    2004-01-01

    Adiabatic quantum computation has recently attracted attention in the physics and computer science communities, but its computational power has been unknown. We settle this question and describe an efficient adiabatic simulation of any given quantum algorithm, which implies that the adiabatic computation model and the conventional quantum circuit model are polynomially equivalent. Our result can be extended to the physically realistic setting of particles arranged on a two-dimensional grid with nearest neighbor interactions. The equivalence between the models provides a new vantage point from which to tackle the central issues in quantum computation, namely designing new quantum algorithms and constructing fault tolerant quantum computers. In particular, by translating the main open questions in quantum algorithms to the language of spectral gaps of sparse matrices, the result makes quantum algorithmic questions accessible to a wider scientific audience, acquainted with mathematical physics, expander theory a...

  11. A numerical investigation of orientifold planar equivalence for quenched mesons

    CERN Document Server

    Lucini, Biagio; Patella, Agostino; Rago, Antonio

    2010-01-01

    We measure on the lattice the quenched pseudoscalar and vector meson masses at a fixed value of the lattice spacing for SU(N) gauge theory with fermions in the adjoint, in the symmetric and in the antisymmetric representations of the gauge group. Simulations are performed for N=3,4,6 in all those representations, with the addition of N=2 for the adjoint representation. We illustrate a strategy for separating the even from the odd-power contributions in 1/N in the masses. Using this technique, we extrapolate the vector mass to the large-N limit in the chiral region and show that at N = infty this mass is the same within errors in all the three representations, as predicted by orientifold planar equivalence. Possible implications of our investigation for studying orientifold planar equivalence in the dynamical case are discussed.

  12. MERCURY EMISSIONS FROM COAL FIRED POWER PLANTS LOCAL IMPACTS ON HUMAN HEALTH RISK.

    Energy Technology Data Exchange (ETDEWEB)

    SULLIVAN, T.M.; BOWERMAN, B.; ADAMS, J.; LIPFERT, F.; MORRIS, S.M.; BANDO, A.; PENA, R.; BLAKE, R.

    2005-12-01

    A thorough quantitative understanding of the processes of mercury emissions, deposition, and translocation through the food chain is currently not available. Complex atmospheric chemistry and dispersion models are required to predict concentration and deposition contributions, and aquatic process models are required to predict effects on fish. However, there are uncertainties in all of these predictions. Therefore, the most reliable method of understanding impacts of coal-fired power plants on Hg deposition is from empirical data. A review of the literature on mercury deposition around sources including coal-fired power plants found studies covering local mercury concentrations in soil, vegetation, and animals (fish and cows). There is strong evidence of enhanced local deposition within 3 km of the chlor-alkali plants, with elevated soil concentrations and estimated deposition rates of 10 times background. For coal-fired power plants, the data show that atmospheric deposition of Hg may be slightly enhanced. On the scale of a few km, modeling suggests that wet deposition may be increased by a factor of two or three over background. The measured data suggest lower increases of 15% or less. The effects of coal-fired plants seem to be less than 10% of total deposition on a national scale, based on emissions and global modeling. The following summarizes our findings from published reports on the impacts of local deposition. In terms of excesses over background the following increments have been observed within a few km of the plant: (1) local soil concentration Hg increments of 30%-60%, (2) sediment increments of 18-30%, (3) wet deposition increments of 11-12%, and (4) fish Hg increments of about 5-6%, based on an empirical finding that fish concentrations are proportional to the square root of deposition. Important uncertainties include possible reductions of RGM to Hg{sub 0} in power plant plumes and the role of water chemistry in the relationship between Hg

  13. MERCURY EMISSIONS FROM COAL FIRED POWER PLANTS LOCAL IMPACTS ON HUMAN HEALTH RISK.

    Energy Technology Data Exchange (ETDEWEB)

    SULLIVAN, T.M.; BOWERMAN, B.; ADAMS, J.; LIPFERT, F.; MORRIS, S.M.; BANDO, A.; PENA, R.; BLAKE, R.

    2005-12-01

    A thorough quantitative understanding of the processes of mercury emissions, deposition, and translocation through the food chain is currently not available. Complex atmospheric chemistry and dispersion models are required to predict concentration and deposition contributions, and aquatic process models are required to predict effects on fish. However, there are uncertainties in all of these predictions. Therefore, the most reliable method of understanding impacts of coal-fired power plants on Hg deposition is from empirical data. A review of the literature on mercury deposition around sources including coal-fired power plants found studies covering local mercury concentrations in soil, vegetation, and animals (fish and cows). There is strong evidence of enhanced local deposition within 3 km of the chlor-alkali plants, with elevated soil concentrations and estimated deposition rates of 10 times background. For coal-fired power plants, the data show that atmospheric deposition of Hg may be slightly enhanced. On the scale of a few km, modeling suggests that wet deposition may be increased by a factor of two or three over background. The measured data suggest lower increases of 15% or less. The effects of coal-fired plants seem to be less than 10% of total deposition on a national scale, based on emissions and global modeling. The following summarizes our findings from published reports on the impacts of local deposition. In terms of excesses over background the following increments have been observed within a few km of the plant: (1) local soil concentration Hg increments of 30%-60%, (2) sediment increments of 18-30%, (3) wet deposition increments of 11-12%, and (4) fish Hg increments of about 5-6%, based on an empirical finding that fish concentrations are proportional to the square root of deposition. Important uncertainties include possible reductions of RGM to Hg{sub 0} in power plant plumes and the role of water chemistry in the relationship between Hg

  14. Inferring Muscle-Tendon Unit Power from Ankle Joint Power during the Push-Off Phase of Human Walking: Insights from a Multiarticular EMG-Driven Model

    Science.gov (United States)

    2016-01-01

    Introduction Inverse dynamics joint kinetics are often used to infer contributions from underlying groups of muscle-tendon units (MTUs). However, such interpretations are confounded by multiarticular (multi-joint) musculature, which can cause inverse dynamics to over- or under-estimate net MTU power. Misestimation of MTU power could lead to incorrect scientific conclusions, or to empirical estimates that misguide musculoskeletal simulations, assistive device designs, or clinical interventions. The objective of this study was to investigate the degree to which ankle joint power overestimates net plantarflexor MTU power during the Push-off phase of walking, due to the behavior of the flexor digitorum and hallucis longus (FDHL)–multiarticular MTUs crossing the ankle and metatarsophalangeal (toe) joints. Methods We performed a gait analysis study on six healthy participants, recording ground reaction forces, kinematics, and electromyography (EMG). Empirical data were input into an EMG-driven musculoskeletal model to estimate ankle power. This model enabled us to parse contributions from mono- and multi-articular MTUs, and required only one scaling and one time delay factor for each subject and speed, which were solved for based on empirical data. Net plantarflexing MTU power was computed by the model and quantitatively compared to inverse dynamics ankle power. Results The EMG-driven model was able to reproduce inverse dynamics ankle power across a range of gait speeds (R2 ≥ 0.97), while also providing MTU-specific power estimates. We found that FDHL dynamics caused ankle power to slightly overestimate net plantarflexor MTU power, but only by ~2–7%. Conclusions During Push-off, FDHL MTU dynamics do not substantially confound the inference of net plantarflexor MTU power from inverse dynamics ankle power. However, other methodological limitations may cause inverse dynamics to overestimate net MTU power; for instance, due to rigid-body foot assumptions. Moving

  15. Development of a human reliability analysis procedure for a low power/shutdown probabilistic safety assessment in pressurized light water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Kang, D. I.; Sung, T. Y.; Park, J. H.; Kim, T. W.; Han, S. H.; Kim, K. Y.; Yang, J. E.; Jung, W. D.; Lee, Y. H.; Hwang, M. J.

    1997-09-01

    A human reliability analysis (HRA) procedure is developed for a low power/shutdown probalistic safety assessment (PSA) in pressurized light water reactors. At first, the HRA procedure developed is based on the two major current methods: THERP (technique for human error rate prediction) and SHARP (systematic human action reliability procedure). Then, it focuses on the specific situation of low power and shutdown operation of pressurized light water reactors. Major characteristics of the HRA procedure are as follows; 1) The use of the work sheet developed increase the plausibility and credibility of the quantification process of human actions and enable use to trace easily it. 2) The explicit use of decision tree could partly eliminate the possible subjectiveness in human reliability analyst`s judgement used for HRA. It is expected that the HRA procedure developed allow human reliability analyst to perform a systematic and consistent HRA. (author). 26 refs., 13 tabs., 8 figs.

  16. Analysis of affinely equivalent Boolean functions

    Institute of Scientific and Technical Information of China (English)

    MENG QingShu; ZHANG HuanGuo; YANG Min; WANG ZhangYi

    2007-01-01

    By some basic transforms and invariant theory, we give two results: 1) an algorithm,which can be used to judge if two Boolean functions are affinely equivalent and to obtain the equivalence relationship if they are equivalent. This is useful in studying Boolean functions and in engineering. For example, we classify all 8-variable homogeneous bent functions of degree 3 into two classes; 2) Reed-Muller codes R(4,6)/R(1,6), R(3,7)/R(1,7) are classified efficiently.

  17. Antireflection design concepts with equivalent layers.

    Science.gov (United States)

    Schallenberg, Uwe B

    2006-03-01

    Some novel concepts of designing antireflection (AR) coatings with equivalent layers are presented. As an introduction, essential papers concerning thin-film optics and AR designs are cited, and the AR problem and a previously introduced AR-hard design type are discussed. Based on the known matrix formalism, a potential AR region, an equivalent stack index, and an equivalent substrate index are defined to use the theory of stop-band suppression as a starting point for the design of broadband AR coatings. The known multicycle AR design type is identified as a typical solution to the AR problem if the presented approach is used.

  18. Multi-objective optimal strategy for steam power system in steel industry based on electricity equivalent calculation%基于等效电法的钢铁企业蒸汽系统多目标运行优化策略

    Institute of Scientific and Technical Information of China (English)

    陈骏; 周伟国; 王海; 李苏

    2016-01-01

    The steam power system in steel industries is featured by a variety of energy and various energy producers. In this paper, a method to convert energy into electricity equivalent is introduced to analyze the efficiency of energy conversion in the system, and mathematical programming and optimization are employed to improve energy management based on the background of steam power system in a large iron and steel company. With the establishment of mixed integer nonlinear programming model which is multi-objective, the global optimal solution will be achieved by solve the multi-objective-constrained model by LINGO step by step on condition that the objectives, the minimum cost of energy hourly and the maximum exergy efficiency, and the constraints including the capacity of power plants, energy demand and operating cost are set. Pareto front is to be achieved by solving the objective function-the maximum exergy efficiency-with cost constraint by the minimum cost of energy hourly multiplying an over-relaxation which is little bigger than 1. Rationality, feasibility and efficiency of ultimate optimization solution by stepwise multi-objective optimization is to be demonstrated in comparison with solutions by single-objective optimization and multi-objective genetic algorithm. The schedule of effective operation at low cost of steam power system is to be well-founded in theory in accordance with the optimal solution.%针对钢铁企业蒸汽系统汽源设备多、能源品种多的特点,以某大型钢铁企业实际运行的蒸汽系统为背景,运用等效电方法对蒸汽系统的能量转换作出科学分析,采用数学规划方法,建立多目标的混合整数非线性规划模型(MINLP)。采用分步优化方法,先以蒸汽系统小时能源总成本最低为目标,将得到的结果乘以松弛系数建立成本约束并以㶲效率最高为目标,利用LINGO软件求得多目标-约束优化模型的全局最优解,再通过改变松弛

  19. Electro-optical equivalent calibration technology for high-energy laser energy meters.

    Science.gov (United States)

    Wei, Ji Feng; Chang, Yan; Sun, Li Qun; Zhang, Kai; Hu, Xiao Yang; Zhang, Wei

    2016-04-01

    Electro-optical equivalent calibration with high calibration power and high equivalence is particularly well-suited to the calibration of high-energy laser energy meters. A large amount of energy is reserved during this process, however, which continues to radiate after power-off. This study measured the radiation efficiency of a halogen tungsten lamp during power-on and after power-off in order to calculate the total energy irradiated by a lamp until the high-energy laser energy meter reaches thermal equilibrium. A calibration system was designed based on the measurement results, and the calibration equivalence of the system was analyzed in detail. Results show that measurement precision is significantly affected by the absorption factor of the absorption chamber and by heat loss in the energy meter. Calibration precision is successfully improved by enhancing the equivalent power and reducing power-on time. The electro-optical equivalent calibration system, measurement uncertainty of which was evaluated as 2.4% (k = 2), was used to calibrate a graphite-cone-absorption-cavity absolute energy meter, yielding a calibration coefficient of 1.009 and measurement uncertainty of 3.5% (k = 2). A water-absorption-type high-energy laser energy meter with measurement uncertainty of 4.8% (k = 2) was considered the reference standard, and compared to the energy meter calibrated in this study, yielded a correction factor of 0.995 (standard deviation of 1.4%).

  20. Electro-optical equivalent calibration technology for high-energy laser energy meters

    Science.gov (United States)

    Wei, Ji Feng; Chang, Yan; Sun, Li Qun; Zhang, Kai; Hu, Xiao Yang; Zhang, Wei

    2016-04-01

    Electro-optical equivalent calibration with high calibration power and high equivalence is particularly well-suited to the calibration of high-energy laser energy meters. A large amount of energy is reserved during this process, however, which continues to radiate after power-off. This study measured the radiation efficiency of a halogen tungsten lamp during power-on and after power-off in order to calculate the total energy irradiated by a lamp until the high-energy laser energy meter reaches thermal equilibrium. A calibration system was designed based on the measurement results, and the calibration equivalence of the system was analyzed in detail. Results show that measurement precision is significantly affected by the absorption factor of the absorption chamber and by heat loss in the energy meter. Calibration precision is successfully improved by enhancing the equivalent power and reducing power-on time. The electro-optical equivalent calibration system, measurement uncertainty of which was evaluated as 2.4% (k = 2), was used to calibrate a graphite-cone-absorption-cavity absolute energy meter, yielding a calibration coefficient of 1.009 and measurement uncertainty of 3.5% (k = 2). A water-absorption-type high-energy laser energy meter with measurement uncertainty of 4.8% (k = 2) was considered the reference standard, and compared to the energy meter calibrated in this study, yielded a correction factor of 0.995 (standard deviation of 1.4%).

  1. The politics of protection: aid, human rights discourse, and power relations in Kyaka II settlement, Uganda.

    Science.gov (United States)

    Clark-Kazak, Christina R

    2010-01-01

    This paper explores the conceptualisation and application of 'protection' by the United Nations High Commissioner (UNHCR), Ugandan government, and Congolese refugees in Kyaka II refugee settlement, Uganda. Analysing the origins and consequences of a demonstration against school fees, and drawing on other ethnographic data, it explores how different interpretations of this incident reflect different conceptions of, and approaches to, protection. Ugandan government officials viewed the demonstration as a security incident; Congolese and Ugandan adults responded with increased monitoring and 'sheltering' of children and young people; students justified the demonstration as a legitimate manifestation of their rights; while UNHCR promoted assistance and resettlement. The paper argues that prevailing protection responses, including 'sensitisation', sheltering, and resettlement, are de-contextualised from daily realities and fail to address the underlying power relations that undermine protection. It concludes with recommendations on how international refugee agencies can reorient assistance to address protection concerns in refugee contexts.

  2. Power-law distributed temporal heterogeneity of human activities promotes cooperation on complex networks

    Science.gov (United States)

    Liu, Chao; Li, Rong

    2016-09-01

    An evolutionary prisoner's dilemma game (PDG) with players located on Barabási-Albert scale-free networks is studied. The impact of players' heterogeneous temporal activity pattern on the evolution of cooperation is investigated. To this end, the normal procedure that players update their strategies immediately after a round of game is discarded. Instead, players update strategies according to their assigned reproduction time, which follows a power-law distribution. We find that the temporal heterogeneity of players' activities facilitates the prosperity of cooperation, indicating the important role of hubs in the maintenance of cooperation on scale-free networks. When the reproduction time is assigned to individuals negatively related to their degrees, a fluctuation of the cooperation level with the increase of the exponent β is observed.

  3. Power assessment for genetic association study of human longevity using offspring of long-lived subjects

    DEFF Research Database (Denmark)

    Tan, Qihua; Zhao, Jing Hua; Li, Shuxia;

    2010-01-01

    Recently, an indirect genetic association approach that compares genotype frequencies in offspring of long-lived subjects and offspring from random families has been introduced to study gene-longevity associations. Although the indirect genetic association has certain advantages over the direct...... and the proportional hazard model for generating individual lifespan. Family genotype data is generated using a genetic linkage program for given SNP allele frequency. Power is estimated by setting the type I error rate at 0.05 and by calculating the Armitage's chi-squared test statistic for 200 replicate samples...... for each setting of the specified allele risk and frequency parameters under different modes of inheritance and for different sample sizes. The indirect genetic association analysis is a valid approach for studying gene-longevity association, but the sample size requirement is about 3-4 time larger than...

  4. Design of a Human Machine Interface for a Reliability Monitoring System of Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yuxin; Yang, Ming; Yan, Shengyuan [Harbin Engineering University, Harbin (Switzerland)

    2014-08-15

    This paper presents the design of a Reliability Monitoring System (RMS) for nuclear power plant which was newly developed by authors. The RMS, combining a dynamic reliability analysis system with an online fault management system, can assist technical personnel with their daily tasks such as system configuration management, maintenance plan making and state monitoring from a point of view that degradation of equipment performance, bad plant configurations and incorrect actions will decrease the probability of systems performing designed functions. For utilizing the RMS, technical personnel will monitor the plant operational state, conform the fault diagnosis, input the intended operating or maintenance actions, and monitor the probability changes of systems through a graphical HMI. A HMI evaluation experiment was conducted using an eye tracking system and a full scale simulator of PWR NPP. Visual data was recorded and analyzed after the experiment. The experiment results are presented and the HMI design problems revealed by the evaluation experiment are discussed.

  5. Equivalent circuit with complex physical constants and equivalent-parameters-expressed dissipation factors of piezoelectric materials

    Institute of Scientific and Technical Information of China (English)

    Chen Yu; Wen Yu-Mei; Li Ping

    2006-01-01

    The equivalent circuit with complex physical constants for a piezoelectric ceramic in thickness mode is established.In the equivalent circuit, electric components (equivalent circuit parameters) are connected to real and imaginary parts of complex physical coefficients of piezoelectric materials. Based on definitions of dissipation factors, three of them (dielectric, elastic and piezoelectric dissipation factors) are represented by equivalent circuit parameters. Since the equivalent circuit parameters are detectable, the dissipation factors can be easily obtained. In the experiments, the temperature and the stress responses of the three dissipation factors are measured.

  6. Social collective intelligence combining the powers of humans and machines to build a smarter society

    CERN Document Server

    Miorandi, Daniele; Rovatsos, Michael

    2014-01-01

    The book focuses on Social Collective Intelligence, a term used to denote a class of socio-technical systems that combine, in a coordinated way, the strengths of humans, machines and collectives in terms of competences, knowledge and problem solving capabilities with the communication, computing and storage capabilities of advanced ICT.Social Collective Intelligence opens a number of challenges for researchers in both computer science and social sciences; at the same time it provides an innovative approach to solve challenges in diverse application domains, ranging from health to education

  7. Human Nature, Power and Institutional Anti-corruption%人性、权力与制度反腐

    Institute of Scientific and Technical Information of China (English)

    蔡娟

    2013-01-01

    Positive aspects of human nature will be promoted in a good atmosphere while evil aspects may be bred in a wicked atmosphere. The alienation and abuse of power is the fundamental cause of corruption although the evil in human nature is the deep root of corruption. Therefore, we must pay attention to the changeable human nature so as to arouse the positive energy of human nature by both external system constraints and internal cultural and psychological constraints. We should strengthen the restriction and supervision over the power, which is the internal demand of human nature and political civilization. We should also strengthen the system design, improve the system performance, standardize the power operation and resist the formation of false system in order to form sound anti-corruption system and improve the institutional anti-corruption level. Leading cadres must get used to using power carefully for the public under the supervision. They should consciously resist the erosion from for-malism, bureaucracy, and hedonistic extravagance so as to create a democratic, equal, fair, harmonious social atmosphere and spirit for the comprehensive and free development of all the people.%人性中的恶是腐败的深层基础,但权力的异化和滥用则是导致腐败的根本原因。必须正视人性中的恶及善恶互变现象,以外在的刚性制度约束和内在的文化心理约束激发人性的正能量;必须加强权力制约和监督,把权力关进制度的笼子里,防微杜渐、惩恶扬善,这是人性向善和政治走向文明的内在需求;必须加强制度设计,提高制度执行力,规范权力运用,防止制度虚置,形成不敢腐的惩戒机制、不能腐的防范机制、不易腐的保障机制,提高制度反腐的科学化水平。广大领导干部必须习惯于在监督下谨慎用权,为民掌好权,自觉抵制形式主义、官僚主义、享乐主义和奢靡之风的侵蚀,为全体人民的

  8. Lexical Equivalence in Business English Translation

    Institute of Scientific and Technical Information of China (English)

    王淼

    2009-01-01

    Business English is English used in business contexts.It is a combination of knowledge in both business and language.Being faithful is of primary importance in business English translation,but a translation only faithful to the original is far from adequate if it is not appropriate to the original in style.Therefore,in doing business translation,the translators should always keep in mind the specific purposes and functions of the original texts and make attempts to render the closet natural equivalent in the target language.This article focuses on equivalence at lexical level in this chapter.Several major tendencies toward word choice are put forward and stylistic equivalence in each case is analyzed at some length.Three criteria are proposed here for choosing suitable words:preciseness,conciseness and gracefulness.If the three criteria are satisfied,stylistic equivalence will also be established.

  9. Lexical Equivalence in Business English Translation

    Institute of Scientific and Technical Information of China (English)

    王淼

    2009-01-01

    Business English is English used in business contexts.It is a combination of knowledge in both business and language.Being faithful is ofprimary importance in business English Iranslation,but a translation only faithful to the original is far from adequate if it is not appropriate to the original in style.Therefore,in doing business translation,the translators should always keep in mind the specific purposes and functions ofthe original texts and make attempts to render the closet natural equivalent in the target language.This atticle focuses on equivalence at lexical level in this chapter.Several major tendencies toward word choice arc put forward and stylistic equivalence in each case is analyzed at some length.Three criteria are proposed here for choosing suitable words:preciseness,concise-ness and gracefulness.1fthe three criteria are satisfied,stylistic equivalence will also be established.

  10. Equivalence Principle, Higgs Boson and Cosmology

    Directory of Open Access Journals (Sweden)

    Mauro Francaviglia

    2013-05-01

    Full Text Available We discuss here possible tests for Palatini f(R-theories together with their implications for different formulations of the Equivalence Principle. We shall show that Palatini f(R-theories obey the Weak Equivalence Principle and violate the Strong Equivalence Principle. The violations of the Strong Equivalence Principle vanish in vacuum (and purely electromagnetic solutions as well as on short time scales with respect to the age of the universe. However, we suggest that a framework based on Palatini f(R-theories is more general than standard General Relativity (GR and it sheds light on the interpretation of data and results in a way which is more model independent than standard GR itself.

  11. Equivalence relations and the reinforcement contingency.

    Science.gov (United States)

    Sidman, M

    2000-07-01

    Where do equivalence relations come from? One possible answer is that they arise directly from the reinforcement contingency. That is to say, a reinforcement contingency produces two types of outcome: (a) 2-, 3-, 4-, 5-, or n-term units of analysis that are known, respectively, as operant reinforcement, simple discrimination, conditional discrimination, second-order conditional discrimination, and so on; and (b) equivalence relations that consist of ordered pairs of all positive elements that participate in the contingency. This conception of the origin of equivalence relations leads to a number of new and verifiable ways of conceptualizing equivalence relations and, more generally, the stimulus control of operant behavior. The theory is also capable of experimental disproof.

  12. The effective theory of Borel equivalence relations

    DEFF Research Database (Denmark)

    Fokina, E.B.; Friedman, S.-D.; Törnquist, Asger Dag

    2010-01-01

    The study of Borel equivalence relations under Borel reducibility has developed into an important area of descriptive set theory. The dichotomies of Silver [20] and Harrington, Kechris and Louveau [6] show that with respect to Borel reducibility, any Borel equivalence relation strictly above...... under effectively Borel reducibility. The resulting structure is complex, even for equivalence relations with finitely many equivalence classes. However use of Kleene's O as a parameter is sufficient to restore the picture from the noneffective setting. A key lemma is that of the existence of two...... effectively Borel sets of reals, neither of which contains the range of the other under any effectively Borel function; the proof of this result applies Barwise compactness to a deep theorem of Harrington (see [5,16]) establishing for any recursive ordinal α the existence of Π singletons whose α...

  13. Equivalent boundary integral equations for plane elasticity

    Institute of Scientific and Technical Information of China (English)

    胡海昌; 丁皓江; 何文军

    1997-01-01

    Indirect and direct boundary integral equations equivalent to the original boundary value problem of differential equation of plane elasticity are established rigorously. The unnecessity or deficiency of some customary boundary integral equations is indicated by examples and numerical comparison.

  14. On the Notion of Equivalence in Translation

    Institute of Scientific and Technical Information of China (English)

    张颖

    2016-01-01

    Thanks to translations, varies cultures are allowed to exchange with one another. One the one hand, this has been promoting the studies of translation. On the other hand, this poses huge challenges on translators, because it is hard to define what is a good target translation when a source text is translated. There is a variety of standards to evaluate the quality of a translation, among which equivalence seems to be the most controversial one. On the analysis of studies on equivalence, this essay discusses the role of equivalence in the practice of translating with illustrations of Chinese-English and English-Chinese translation. Indeed, to translate a source text into a target one is based on the equivalence among languages. However, in the process of translating, it can be adjusted to some extent for the sake of the acceptability in the target culture.

  15. interpratation: of equivalences and cultural untranslatability

    African Journals Online (AJOL)

    jgmweri

    Interpretation: signs and meaning, diversity in language use, equivalences and ... movement of the hands, arms or body, and facial expressions to express ... people who belong to the same culture given the similar experiences they have gone.

  16. ON THE EQUIVALENCE OF THE ABEL EQUATION

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This article uses the reflecting function of Mironenko to study some complicated differential equations which are equivalent to the Abel equation. The results are applied to discuss the behavior of solutions of these complicated differential equations.

  17. REFractions: The Representing Equivalent Fractions Game

    Science.gov (United States)

    Tucker, Stephen I.

    2014-01-01

    Stephen Tucker presents a fractions game that addresses a range of fraction concepts including equivalence and computation. The REFractions game also improves students' fluency with representing, comparing and adding fractions.

  18. Structured information analysis for human reliability analysis of emergency tasks in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Won Dea; Kim, Jae Whan; Park, Jin Kyun; Ha, Jae Joo [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-02-01

    More than twenty HRA (Human Reliability Analysis) methodologies have been developed and used for the safety analysis in nuclear field during the past two decades. However, no methodology appears to have universally been accepted, as various limitations have been raised for more widely used ones. One of the most important limitations of conventional HRA is insufficient analysis of the task structure and problem space. To resolve this problem, we suggest SIA (Structured Information Analysis) for HRA. The proposed SIA consists of three parts. The first part is the scenario analysis that investigates the contextual information related to the given task on the basis of selected scenarios. The second is the goals-means analysis to define the relations between the cognitive goal and task steps. The third is the cognitive function analysis module that identifies the cognitive patterns and information flows involved in the task. Through the three-part analysis, systematic investigation is made possible from the macroscopic information on the tasks to the microscopic information on the specific cognitive processes. It is expected that analysts can attain a structured set of information that helps to predict the types and possibility of human error in the given task. 48 refs., 12 figs., 11 tabs. (Author)

  19. Nuclear Nox4 Role in Stemness Power of Human Amniotic Fluid Stem Cells

    Directory of Open Access Journals (Sweden)

    Tullia Maraldi

    2015-01-01

    Full Text Available Human amniotic fluid stem cells (AFSC are an attractive source for cell therapy due to their multilineage differentiation potential and accessibility advantages. However the clinical application of human stem cells largely depends on their capacity to expand in vitro, since there is an extensive donor-to-donor heterogeneity. Reactive oxygen species (ROS and cellular oxidative stress are involved in many physiological and pathophysiological processes of stem cells, including pluripotency, proliferation, differentiation, and stress resistance. The mode of action of ROS is also dependent on the localization of their target molecules. Thus, the modifications induced by ROS can be separated depending on the cellular compartments they affect. NAD(PH oxidase family, particularly Nox4, has been known to produce ROS in the nucleus. In the present study we show that Nox4 nuclear expression (nNox4 depends on the donor and it correlates with the expression of transcription factors involved in stemness regulation, such as Oct4, SSEA-4, and Sox2. Moreover nNox4 is linked with the nuclear localization of redox sensitive transcription factors, as Nrf2 and NF-κB, and with the differentiation potential. Taken together, these results suggest that nNox4 regulation may have important effects in stem cell capability through modulation of transcription factors and DNA damage.

  20. Human factors involvement in bringing the power of AI to a heterogeneous user population

    Science.gov (United States)

    Czerwinski, Mary; Nguyen, Trung

    1994-01-01

    The Human Factors involvement in developing COMPAQ QuickSolve, an electronic problem-solving and information system for Compaq's line of networked printers, is described. Empowering customers with expert system technology so they could solve advanced networked printer problems on their own was a major goal in designing this system. This process would minimize customer down-time, reduce the number of phone calls to the Compaq Customer Support Center, improve customer satisfaction, and, most importantly, differentiate Compaq printers in the marketplace by providing the best, and most technologically advanced, customer support. This represents a re-engineering of Compaq's customer support strategy and implementation. In its first generation system, SMART, the objective was to provide expert knowledge to Compaq's help desk operation to more quickly and correctly answer customer questions and problems. QuickSolve is a second generation system in that customer support is put directly in the hands of the consumers. As a result, the design of QuickSolve presented a number of challenging issues. Because the produce would be used by a diverse and heterogeneous set of users, a significant amount of human factors research and analysis was required while designing and implementing the system. Research that shaped the organization and design of the expert system component as well.