WorldWideScience

Sample records for human centred cim

  1. Determination of Zn-citrate in human milk by CIM monolithic chromatography with atomic and mass spectrometry detection.

    Science.gov (United States)

    Milačič, Radmila; Ajlec, Dejan; Zuliani, Tea; Žigon, Dušan; Ščančar, Janez

    2012-11-15

    In human milk zinc (Zn) is bound to proteins and low molecular mass (LMM) ligands. Numerous investigations demonstrated that Zn bioavailability in human milk is for infant much higher than in cow's milk. It was presumed that in the LMM human milk fraction highly bioavailable Zn-citrate prevails. However, literature data are controversial regarding the amount of Zn-citrate in human milk since analytical procedures reported were not quantitative. So, complex investigation was carried out to develop analytical method for quantitative determination of this biologically important molecule. Studies were performed within the pH range 5-7 by the use of synthetic solutions of Zn-citrate prepared in HEPES, MOPS and MES buffers. Zn-citrate was separated on weak anion-exchange convective interaction media (CIM) diethylaminoethyl (DEAE) monolithic chromatographic column using NH(4)NO(3) as an eluent. Separated Zn species were determined by flame atomic absorption spectrometry (FAAS) or inductively coupled plasma mass spectrometry (ICP-MS). Quantitative separation of Zn-citrate complexes ([Zn(Cit)](-) and [Zn(Cit)(2)](4-); column recoveries 94-102%) and good repeatability and reproducibility of results with relative standard deviation (RSD±3.0%) were obtained. In fractions under the chromatographic peaks Zn-binding ligand was identified by electrospray ionization tandem mass spectrometry (ESI-MS-MS). Limits of detection (LOD) for determination of Zn-citrate species by CIM DEAE-FAAS and CIM DEAE-ICP-MS were 0.01 μg Zn mL(-1) and 0.0005 μg Zn mL(-1), respectively. Both techniques were sensitive enough for quantification of Zn-citrate in human milk. Results demonstrated that about 23% of total Zn was present in the LMM milk fraction and that LMM-Zn corresponded to Zn-citrate. The developed speciation method represents a reliable analytical tool for investigation of the percentage and the amount of Zn-citrate in human milk.

  2. "on soft CIMS"-from PDM to CIMS%"软CIMS"论--从PDM到CIMS

    Institute of Scientific and Technical Information of China (English)

    邹恒祺; 杨龙; 陈贵祥

    2000-01-01

    论述了CAPP是信息集成的"关节点",同时提出了符合国情的"软CIMS"概念,并对"软CIMS"的核心技术进行了初步探讨.文中突出按CIM哲理逐步实现符合实际的计算机集成制造系统(CIMS)的思想.

  3. Towards Human-Centred Design

    Science.gov (United States)

    Bannon, Liam J.

    The field of HCI has evolved and expanded dramatically since its origin in the early 1980’s. The HCI community embraces a large community of researchers and practitioners around the world, from a variety of disciplinary backgrounds in the human and social sciences, engineering and informatics, and more recently, the arts and design disciplines. This kaleidoscope of cultures and disciplines as seen at INTERACT Conferences provides a rich pool of resources for examining our field. Applications are increasingly exploring our full range of sensory modalities, and merging the digital and physical worlds. WiFi has opened up a huge design space for mobile applications. A focus on usability of products and services has been complemented by an emphasis on engagement, enjoyment and experience. With the advent of ubiquitous computing, and the emergence of “The Internet of Things”, new kinds of more open infrastructures make possible radically new kinds of applications. The sources of innovation have also broadened, to include human and social actors outside of the computing and design organizations. The question is to what extent is our mainstream thinking in the HCI field ready for the challenges of this Brave New World? Do the technological and social innovations that we see emerging require us to re-shape, or even, re-create, our field, or is it a case of a more gradual evolution and development of that which we already know? In this closing Keynote, I will provide a perspective on the evolution and development of the HCI field, looking backwards as well as forwards, in order to determine what are some of the changes of significance in the field. This “broad-brush” approach to what I term “ human-centred design” will be complemented by the examination of specific projects and applications, to help anchor some of the discussion. Areas such as user-centred design, participatory design, computer-supported cooperative work and learning, and interaction design, in

  4. CORBA Based CIMS Application Integration

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Common object request broker architecture (CORBA) provides the framework and the mechanism for distributed object operation. It can also be applied to computer integrated manufacturing system (CIMS) application integration. This paper studies the CIMS information service requirement, presents a CORBA based integration approach including the CORBA based CIM information system architecture and the application integration mechanism, and discusses the relationship between CORBA and the CIM application integration platform.

  5. Centre for human development, stem cells & regeneration.

    Science.gov (United States)

    Oreffo, Richard O C

    2014-01-01

    The Centre for Human Development, Stem Cells and Regeneration (CHDSCR) was founded in 2004 as a cross-disciplinary research and translational program within the Faculty of Medicine at the University of Southampton. The Centre undertakes fundamental research into early development and stem cells together with applied translational research for patient benefit. The Centre has vibrant and thriving multidisciplinary research programs that harness the translational strength of the Faculty together with an innovative Stem Cell PhD program, outstanding clinical infrastructure and enterprise to deliver on this vision.

  6. Tensions in human-centred design

    NARCIS (Netherlands)

    Steen, M.G.D.

    2011-01-01

    In human-centred design (HCD), researchers and designers attempt to cooperate with and learn from potential users of the products or services which they are developing. Their goal is to develop products or services that match users' practices, needs and preferences. In this position paper it is argu

  7. Biological Inspiration in Human Centred Robotics

    Institute of Scientific and Technical Information of China (English)

    HU Huo-sheng; LIU Jin-dong; Calderon Carlos A

    2004-01-01

    Human centred robotics (HCR) concerns with the development of various kinds of intelligent systems and robots that will be used in environments coexisting with humans. These systems and robots will be interactive and useful assistants/companions for people in different ages, situations, activities and environments in order to improve the quality of life. This paper presents the autors' current research work toward the development of advanced theory and technologies for HCR applications, based on inspiration from biological systems. More specifically, both bio-mimetic system modelling and robot learning by imitation are discussed respectively, and some preliminary results are demonstrated.

  8. Use of the CIM Ontology

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, Scott; Britton, Jay; Devos, Arnold N.; Widergren, Steven E.

    2006-02-08

    There are many uses for the Common Information Model (CIM), an ontology that is being standardized through Technical Committee 57 of the International Electrotechnical Commission (IEC TC57). The most common uses to date have included application modeling, information exchanges, information management and systems integration. As one should expect, there are many issues that become apparent when the CIM ontology is applied to any one use. Some of these issues are shortcomings within the current draft of the CIM, and others are a consequence of the different ways in which the CIM can be applied using different technologies. As the CIM ontology will and should evolve, there are several dangers that need to be recognized. One is overall consistency and impact upon applications when extending the CIM for a specific need. Another is that a tight coupling of the CIM to specific technologies could limit the value of the CIM in the longer term as an ontology, which becomes a larger issue over time as new technologies emerge. The integration of systems is one specific area of interest for application of the CIM ontology. This is an area dominated by the use of XML for the definition of messages. While this is certainly true when using Enterprise Application Integration (EAI) products, it is even more true with the movement towards the use of Web Services (WS), Service-Oriented Architectures (SOA) and Enterprise Service Buses (ESB) for integration. This general IT industry trend is consistent with trends seen within the IEC TC57 scope of power system management and associated information exchange. The challenge for TC57 is how to best leverage the CIM ontology using the various XML technologies and standards for integration. This paper will provide examples of how the CIM ontology is used and describe some specific issues that should be addressed within the CIM in order to increase its usefulness as an ontology. It will also describe some of the issues and challenges that will

  9. Virtual CIM and Digital Manufacturing

    Institute of Scientific and Technical Information of China (English)

    Sev V.Nagalingam; Grier C.I.Lin

    2006-01-01

    Manufacturing enterprises play an important role in improving the economic environment of a country.Today, the capability to produce high quality products with shorter delivery time and the ability to produce according to the diverse customer requirements has become the characteristics of successful manufacturing industries. Application of intelligent manufacturing systems and Computer integrated manufacturing (CIM) are the most effective methods for overcoming the issues faced by present day manufactures while retaining the employment level and revenue of a country in today's highly competitive global market. With the developments taking place in CIM and its related technologies, the application of CIM in manufacturing enterprises has become a reality from the dream. This paper highlights the historical developments towards automation and the need for CIM systems. Furthermore, it analyses some new terms such as agile manufacturing, digital manufacturing, agent-based manufacturing and others, which have been emerging recently, and argues all these new technologies are the subsystems of CIM. In addition, this paper provides a new direction in CIM to fulfil the emerging challenges in today's global market and to satisfy the emerging need of virtual enterprises in the form of Virtual CIM.

  10. Integrating EMIS in CIMS

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Enterprise management information system (EMIS) in Manufacturing CIMS Int egrating Platform (MACIP), refers to a computer system that manages the information for running an enterprise. A typ ical EMIS consists of a group of closely connected functions such as production planning, material management, accounting, quality management, etc. The EMIS exc h anges information with the CAD/CAPP system in the design department, and the sho p floor controller (SFC) in the manufacturing department, while the global infor mation system (GIS) of MACIP supplies the mechanism for information sharing with in the enterprise. This paper introduces the EMIS model for a typical manu facturing enterprise, then analyses the interface of the EMIS with the CAD/CAPP system and the SFC. A technical scheme for integrating the EMIS with the GIS is given. This scheme considers the integration of some MRPII systems in the marke t, and adopts advanced industrial standards to ensure its flexibility and reusab ility.

  11. Integrated Quality Information System of CIMS

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The computer integrated manufacturing system (CIMS), which is called the 21st century's production mode, is the inevitable course of manufacturing industry development. The integrated quality information system (IQIS), which is the essential component of CIMS, will be the powerful assurance to carry out a CIMS project. In this paper, the concept and the system structure and function of IQIS are discussed. The relationship between IQIS and other component systems of CIMS is analyzed.

  12. Human Centred Design: a bibliometric overview based on Science Direct

    National Research Council Canada - National Science Library

    Lucas José Garcia; Giselle Schmidt Alves Díaz Merino; Susana Cristina Domenech; Eugenio Andres Díaz Merino; Adilson Luiz Pinto

    2016-01-01

    This article aims to realize a bibliometric review on Science Direct to create a outlook about Human Centred Design in order to identify the most significant authors, journals and key-words as well...

  13. Human-centred Methods of Social and Technical Design

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    Different inderstandings of design are presented.The historical background of human-centred designis described.Methods of social shaping are described in detailand the author's research experiences with using these methods in differentinternational projects presented and a model tointegrate...... technical and social perspective of design is suggested....

  14. Benefits of human-centred design in open innovation projects

    NARCIS (Netherlands)

    Steen, M.G.D.; Aarts, O.A.J.; Broekman, C.C.M.T.

    2012-01-01

    Human-centred design (HCD) is a form of open innovation in which researchers and designers cooperate with (potential) users or customers, e.g. in co-design workshops, interviews, user tests and trials. Based on a case study of two open innovation projects in which HCD activities were organized (TA2

  15. Characterization of CIM monoliths as enzyme reactors.

    Science.gov (United States)

    Vodopivec, Martina; Podgornik, Ales; Berovic, Marin; Strancar, Ales

    2003-09-25

    The immobilization of the enzymes citrate lyase, malate dehydrogenase, isocitrate dehydrogenase and lactate dehydrogenase to CIM monolithic supports was performed. The long-term stability, reproducibility, and linear response range of the immobilized enzyme reactors were investigated along with the determination of the kinetic behavior of the enzymes immobilized on the CIM monoliths. The Michaelis-Menten constant K(m) and the turnover number k(3) of the immobilized enzymes were found to be flow-unaffected. Furthermore, the K(m) values of the soluble and immobilized enzyme were found to be comparable. Both facts indicate the absence of a diffusional limitation in immobilized CIM enzyme reactors.

  16. Pressure drop in CIM disk monolithic columns.

    Science.gov (United States)

    Mihelic, Igor; Nemec, Damjan; Podgornik, Ales; Koloini, Tine

    2005-02-11

    Pressure drop analysis in commercial CIM disk monolithic columns is presented. Experimental measurements of pressure drop are compared to hydrodynamic models usually employed for prediction of pressure drop in packed beds, e.g. free surface model and capillary model applying hydraulic radius concept. However, the comparison between pressure drop in monolith and adequate packed bed give unexpected results. Pressure drop in a CIM disk monolithic column is approximately 50% lower than in an adequate packed bed of spheres having the same hydraulic radius as CIM disk monolith; meaning they both have the same porosity and the same specific surface area. This phenomenon seems to be a consequence of the monolithic porous structure which is quite different in terms of the pore size distribution and parallel pore nonuniformity compared to the one in conventional packed beds. The number of self-similar levels for the CIM monoliths was estimated to be between 1.03 and 2.75.

  17. Development of CIMS and FMS in Faults Diagnosis System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The research and practice of CIMS and FMS has brought about a great development to advanced manufacturing systems for decades. The experience of failure and success during the process of development is a revelation and reference for the design of a fault diagnosis system. This paper focuses on its function of directing to the design of a fault diagnosis system in terms of the flexibility of the system, the human's importance in the system, and the design of a distributed system. In view of the tendency of CIMS and FMS, the article also states the principle that the new fault diagnosis system should be improved by enhancing hardware in software, remote Internet service, and sustainable development.

  18. Communication System for CIMS Application Integration Platform

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    CIMS has seen the growth of multiple incompatible hardware architectur es, each architecture supporting several incompatible operating systems, and eac h platform operating with various incompatible development tools (e.g., programm ing language compilers, DBMS, etc.) and one or more incompatible graphic user in terfaces. Also, the growth of the Internet, the World-Wide Web, has introduced new dimensio ns of complexity into the development process. All of these must be dealt with a s the application is made workable in a distributed client-server environment. This paper outlines the architecture of a communication system for the CIMS appl ication integration platform. The communication system makes possible the reque st for service across heterogeneous platforms and networks, and provides some co mmon solutions to issues common to CIMS applications.

  19. Pengelolaan Risiko pada Updating Computer Integrated Manufacturing (CIM di Perusahaan Pakan Ternak

    Directory of Open Access Journals (Sweden)

    Wiwin Widiasih

    2013-03-01

    Full Text Available Risiko adalah kemungkinan terjadinya penyimpangan dari harapan yang dapat menimbulkan kerugian. Pengelolaan risiko yang baik akan memberikan keuntungan bagi perusahaan. Sama dengan pelaksanaan proyek-proyek yang lain, maka updating CIM di perusahaan ini tidak tertutup kemungkinan terjadinya risiko. Maka peneliti akan menerapkan manajemen risiko untuk updating CIM. Penelitian ini bertujuan untuk memberikan gambaran potensi risiko yang muncul ketika melakukan updating pada CIM dan memberikan rekomendasi penanganan risiko untuk proyek serupa di masa akan datang. Pengelolaan risiko dilakukan dengan mengadopsi framework ISO 31000:2009. Pada penelitian ini, konsep implementasi sistem/updating CIM mengadopsi konsep Meyfroidt sebagai kerangka kerja untuk mengidentifikasi risiko. Identifikasi risiko dilakukan dengan berdasarkan pada aktivitas, kemudian risiko yang telah teridentifikasi diklasifikasikan ke dalam empat aspek risiko yaitu technical, human resources, organization and control, dan financial. Risiko yang paling banyak muncul adalah aspek human resources. Penanganan risiko dilakukan dengan mencari hubungan keterkaitan sebab akibat antar risiko ekstrim. Dalam updating CIM selanjutnya, perusahaan perlu memperhatikan aspek human resources karena risiko yang diidentifikasi banyak disebabkan karena kurangnya kompetensi SDM. Selain itu memperhatikan permasalahan dalam hal ketidakakuratan engineering design, koordinasi antar anggota tim, pengiriman alat/mesin oleh supplier, dan kecelakaan kerja.

  20. A Human-Centred Tangible approach to learning Computational Thinking

    Directory of Open Access Journals (Sweden)

    Tommaso Turchi

    2016-08-01

    Full Text Available Computational Thinking has recently become a focus of many teaching and research domains; it encapsulates those thinking skills integral to solving complex problems using a computer, thus being widely applicable in our society. It is influencing research across many disciplines and also coming into the limelight of education, mostly thanks to public initiatives such as the Hour of Code. In this paper we present our arguments for promoting Computational Thinking in education through the Human-centred paradigm of Tangible End-User Development, namely by exploiting objects whose interactions with the physical environment are mapped to digital actions performed on the system.

  1. Human Centred Design: a bibliometric overview based on Science Direct

    OpenAIRE

    Lucas José Garcia; Giselle Schmidt Alves Díaz Merino; Susana Cristina Domenech; Eugenio Andres Díaz Merino; Adilson Luiz Pinto

    2016-01-01

    This article aims to realize a bibliometric review on Science Direct to create a outlook about Human Centred Design in order to identify the most significant authors, journals and key-words as well as the most recurrent denomination about the subject. The method employed consist of application of three classical bibliometric laws: the Inverse Square Law of Lotka; the Bradford’s Law of Scattering and; The frequency law of words in a text of Zipf. The results indicate that the subject is not a ...

  2. Visual peripersonal space centred on the face in humans.

    Science.gov (United States)

    Làdavas, E; Zeloni, G; Farnè, A

    1998-12-01

    A convergent series of studies in monkeys and man suggests that the computation of visual space is performed in several brain regions for different behavioural purposes. Among these multiple spatial areas, the ventral intraparietal cortex, the putamen and the ventral aspect of the premotor cortex (area 6) contain a system for representing visual space near the face (peripersonal space). In these cerebral areas some neurons are bimodal: they have tactile receptive fields on the face, and they can also be driven by visual stimuli located near the tactile field. The spatial correspondence between the visual and tactile receptive fields provides a map of near visual space coded in body-part-centred co-ordinates. In the present study we demonstrate for the first time the existence of a visual peripersonal space centred on the face in humans. In patients with right hemispheric lesions, visual stimuli delivered in the space near the ipsilesional side of the face extinguished tactile stimuli on the contralesional side (cross-modal visuotactile extinction) to the same extent as did an ipsilesional tactile stimulation (unimodal tactile extinction). Furthermore, a visual stimulus presented in the proximity of the contralesional side of the face improved the detection of a left tactile stimulus: i.e. under bilateral tactile presentation patients were more accurate to report the presence of a left tactile stimulus when a simultaneous visual stimulus was presented near the left side of the face. However, when visual stimuli were delivered far from the face, visuotactile extinction and visuotactile facilitation effects were dramatically reduced. These findings are consistent with the hypothesis of a representation of visual peripersonal space coded in bodypart-centred co-ordinates, and they provide a striking demonstration of the modularity of human visual space.

  3. 28 CFR 524.76 - Appeals of CIM classification.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Appeals of CIM classification. 524.76..., CLASSIFICATION, AND TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.76 Appeals of CIM classification. An inmate may at any time appeal (through the Administrative Remedy Program)...

  4. Human Centred Design: a bibliometric overview based on Science Direct

    Directory of Open Access Journals (Sweden)

    Lucas José Garcia

    2016-05-01

    Full Text Available This article aims to realize a bibliometric review on Science Direct to create a outlook about Human Centred Design in order to identify the most significant authors, journals and key-words as well as the most recurrent denomination about the subject. The method employed consist of application of three classical bibliometric laws: the Inverse Square Law of Lotka; the Bradford’s Law of Scattering and; The frequency law of words in a text of Zipf. The results indicate that the subject is not a main subject of Design and related areas and does not have a main author based on Science Direct. The journals covered with more articles about the subject are the International Journal of Industrial Ergonomics and the Applied Ergonomics.

  5. Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways.

    Science.gov (United States)

    Yanagisawa, Kiyoshi; Konishi, Hiroyuki; Arima, Chinatsu; Tomida, Shuta; Takeuchi, Toshiyuki; Shimada, Yukako; Yatabe, Yasushi; Mitsudomi, Tetsuya; Osada, Hirotaka; Takahashi, Takashi

    2010-12-01

    Various stresses of the tumor microenvironment produced by insufficient nutrients, pH, and oxygen can contribute to the generation of altered metabolic and proliferative states that promote the survival of metastatic cells. Among many cellular stress-response pathways activated under such conditions are the hypoxia-inducible factor (HIF) pathway and the unfolded protein response (UPR), which is elicited as a response to endoplasmic reticulum (ER) stress. In this study, we report the identification of a novel cancer invasion and metastasis-related gene (hereafter referred to as CIM, also called ERLEC1), which influences both of these stress-response pathways to promote metastasis. CIM was identified by comparing the gene expression profile of a highly metastatic human lung cancer cell line with its weakly metastatic parental clone. We showed that CIM is critical for metastatic properties in this system. Proteomic approaches combined with bioinformatic analyses revealed that CIM has multifaceted roles in controlling the response to hypoxia and ER stress. Specifically, CIM sequestered OS-9 from the HIF-1α complex and PHD2, permitting HIF-1α accumulation by preventing its degradation. Ectopic expression of CIM in lung cancer cells increased their tolerance to hypoxia. CIM also modulated UPR through interaction with the key ER stress protein BiP, influencing cell proliferation under ER stress conditions. Our findings shed light on how tolerance to multiple cellular stresses at a metastatic site can be evoked by an integrated mechanism involving CIM, which can function to coordinate those responses in a manner that promotes metastatic cell survival.

  6. Closed incision management with negative pressure wound therapy (CIM): biomechanics.

    Science.gov (United States)

    Wilkes, Robert Peyton; Kilpad, Deepak V; Zhao, Yabin; Kazala, Richard; McNulty, Amy

    2012-03-01

    A novel closed incision management with negative pressure wound therapy (CIM) has been developed for convenient use with closed incisions that has the potential to be beneficial for patients at risk for postoperative complications. Incisions are typically under lateral tension. This study explored the biomechanical mechanisms by which integrity of the incisional closure is enhanced by CIM. CIM was hypothesized to affect local stresses around closed incisions in a beneficial manner. Finite element analyses (FEA) indicated that application of CIM decreased the lateral stresses ~50% around the incision and changed the direction of the stresses to a distribution that is typical of intact tissue. Bench evaluations corroborated findings that CIM significantly increased the force required to disrupt the closed incision by ~50% as compared with closure alone. In conclusion, using 2 FEAs and bench modeling, CIM was shown to reduce and normalize tissue stresses and bolster appositional forces at the incision.

  7. Describing Earth System Simulations with the Metafor CIM

    Directory of Open Access Journals (Sweden)

    B. N. Lawrence

    2012-06-01

    Full Text Available The Metafor project has developed a Common Information Model (CIM using the ISO1900 series formalism to describe the sorts of numerical experiments carried out by the earth system modelling community, the models they use, and the simulations that result. Here we describe the mechanism by which the CIM was developed, and its key properties. We introduce the conceptual and application versions and the controlled vocabularies developed in the context of supporting the fifth Coupled Model Intercomparison Project (CMIP5. We describe how the CIM has been used in experiments to describe model coupling properties and describe the near term expected evolution of the CIM.

  8. Describing Earth system simulations with the Metafor CIM

    Science.gov (United States)

    Lawrence, B. N.; Balaji, V.; Bentley, P.; Callaghan, S.; DeLuca, C.; Denvil, S.; Devine, G.; Elkington, M.; Ford, R. W.; Guilyardi, E.; Lautenschlager, M.; Morgan, M.; Moine, M.-P.; Murphy, S.; Pascoe, C.; Ramthun, H.; Slavin, P.; Steenman-Clark, L.; Toussaint, F.; Treshansky, A.; Valcke, S.

    2012-11-01

    The Metafor project has developed a common information model (CIM) using the ISO19100 series formalism to describe numerical experiments carried out by the Earth system modelling community, the models they use, and the simulations that result. Here we describe the mechanism by which the CIM was developed, and its key properties. We introduce the conceptual and application versions and the controlled vocabularies developed in the context of supporting the fifth Coupled Model Intercomparison Project (CMIP5). We describe how the CIM has been used in experiments to describe model coupling properties and describe the near term expected evolution of the CIM.

  9. Describing Earth system simulations with the Metafor CIM

    Directory of Open Access Journals (Sweden)

    B. N. Lawrence

    2012-11-01

    Full Text Available The Metafor project has developed a common information model (CIM using the ISO19100 series formalism to describe numerical experiments carried out by the Earth system modelling community, the models they use, and the simulations that result. Here we describe the mechanism by which the CIM was developed, and its key properties. We introduce the conceptual and application versions and the controlled vocabularies developed in the context of supporting the fifth Coupled Model Intercomparison Project (CMIP5. We describe how the CIM has been used in experiments to describe model coupling properties and describe the near term expected evolution of the CIM.

  10. The Information Integration of CAPP in CIMS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper analyzes the flow of the process design an d the fountain of the technique data in a manufacturing enterprise, and discusse s the information flows between CAPP and other systems in CIMS, such as CAD syst em and Enterprise Resource Planning (ERP) system. And then, it discusses the pla ns of information integration between CAPP and CAD, as well as between CAPP and ERP. To design the processes of a product requires the manufacture information, such as blank material and machine tool, which is s...

  11. CORBA Based Information Integration Platform for CIMS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A new information integration platform for computer integrated manufacturing system(CIMS) is presented, which is based on agent and CORBA. CORBA enhances the system integration be-cause it is an industry-standard for interoperable, distributed objects across heterogeneous hardware andsoftware platform. Agent technology is used to improve intelligence of integration system. In order to im-plement the information integration platform, we use network integration server to integrate network, de-sign a generic database agent to integrate database, adopt multi-agent based architecture to integrate appli-cation, and utilize wrapper as CORBA object to integrate legacy code.

  12. 28 CFR 524.72 - CIM assignment categories.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false CIM assignment categories. 524.72 Section... assignment categories. CIM cases are classified according to the following assignments: (a) Witness Security... or federal penal (which includes correctional and detention facilities) institutions. This assignment...

  13. Study on Integrated Quality Assurance System in CIMS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Integrated Quality Assurance System (IQAS) is an important part of CIMS.This paper introduces the architecture of IQAS,elaborates the philosophy of quality assurance and quality control in CIMS.A type of function model is proposed.Meanwhile, details of the model are described.

  14. Person-centred ergonomics: a Brantonian view of human factors

    National Research Council Canada - National Science Library

    Oborne, David J; Oborne, D.T

    1993-01-01

    ... Cataloguing in Publication Data Person-Centred Ergonomics A catalogue record for this book is available from the British Library ISBN 0-203-22123-0 Master e-book ISBN ISBN 0-203-27588-8 (Adobe eR...

  15. Analysis of quality costs - A critical element in CIM

    Science.gov (United States)

    Unal, Resit; Dean, Edwin B.

    1990-01-01

    Computer integrated manufacturing (CIM) is a cohesive database of manufacturing information, providing an opportunity to track quality costs and measure progress toward their reduction. This paper presents the quality cost concept as an approach to identify, measure and reduce quality costs while improving quality within CIM. The effect of advanced failure prevention methodologies, such as continuous process improvement and the quality engineering methods of Taguchi, on quality and cost, is discussed.

  16. A human capital predictive model for agent performance in contact centres

    Directory of Open Access Journals (Sweden)

    Chris Jacobs

    2011-03-01

    Full Text Available Orientation: Currently no integrative model exists that can explain the phenomena contributing to agent performance in the South African contact centre industry.Research purpose: The primary focus of this article was to develop a theoretically derived human capital predictive model for agent performance in contact centres and Business Process Outsourcing (BPO based on a review of current empirical research literature.Motivation for the study: The study was motivated by the need for a human capital predictive model that can predict agent and overall business performance.Research design: A nonempirical (theoretical research paradigm was adopted for this study and more specifically a theory or model-building approach was followed. A systematic review of published empirical research articles (for the period 2000–2009 in scholarly search portals was performed.Main findings: Eight building blocks of the human capital predictive model for agent performance in contact centres were identified. Forty-two of the human capital contact centre related articles are detailed in this study. Key empirical findings suggest that person– environment fit, job demands-resources, human resources management practices, engagement, agent well-being, agent competence; turnover intention; and agent performance are related to contact centre performance.Practical/managerial implications: The human capital predictive model serves as an operational management model that has performance implications for agents and ultimately influences the contact centre’s overall business performance.Contribution/value-add: This research can contribute to the fields of human resource management (HRM, human capital and performance management within the contact centre and BPO environment.

  17. Human heredity after 1945: moving populations centre stage.

    Science.gov (United States)

    Bangham, Jenny; de Chadarevian, Soraya

    2014-09-01

    The essays in this issue look at the contested history of human heredity after 1945 from a new analytical angle, that of populations and the ways in which they were constructed and studied. One consequence of this approach is that we do not limit our attention to the disciplinary study of genetics. After the Second World War, populations became a central topic for an array of fields, including demography, anthropology, epidemiology, and public health. Human heredity had a role in all of these: demographers carried out mental surveys in efforts to distinguish hereditary from environmental factors, doctors screened newborns and tested pregnant women for chromosome disorders; anthropologists collected blood from remote locations to gain insights into the evolutionary history of human populations; geneticists monitored people exposed to radiation. Through this work, populations were labelled as clinical, normal, primitive, pure, vulnerable or exotic. We ask: how were populations chosen, who qualified as members, and how was the study of human heredity shaped by technical, institutional and geopolitical conditions? By following the practical and conceptual work to define populations as objects of research, the essays trace the circulation of practices across different fields and contexts, bringing into view new actors, institutions, and geographies. By doing so the collection shows how human heredity research was linked to the broader politics of the postwar world, one profoundly conditioned by Cold War tensions, by nationalist concerns, by colonial and post-colonial struggles, by modernisation projects and by a new internationalism. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Separation of pegylated recombinant proteins and isoforms on CIM ion exchangers.

    Science.gov (United States)

    Gašperšič, Jernej; Podgornik, Aleš; Kramberger, Petra; Jarc, Marko; Jančar, Janez; Žorž, Mirjan; Krajnc, Nika Lendero

    2016-10-15

    Protein pegylation is a process of covalent attachment of a polyethylene glycol (PEG) group to the protein tertiary structure that can "mask" the agent from the immune system and also increases the hydrodynamic size of the agent. Usually the pegylation prolongs the protein stability in the organism due to reduced renal clearance and provides superior water solubility to hydrophobic molecules. The mono-pegylated form of protein is usually prefered for medical applications. Different conditions with different PEG reagents have to be tested to find optimal pegylation procedure with specific protein. The goal of this study was to prepare screening method for separation of random mono-pegylated protein. Cytochrome C and beta lactoglobulin were pegylated with four reagents and a complete screening of several chromatographic monoliths in ion exchange mode with different buffers was performed to optimaly separate each mono-pegylated protein. The screening method was developed that produces optimal separation of target pegylated protein on CIM monoliths. Because of short chromatographic run time, CIM monoliths are perfect candidates to test alot of parameters. The results obtained show that each protein has its own unique separation parameters (pH, ionexchange ligand, buffer type). Two biopharmaceuticals were isolated using protocol: super human leptin antagonist (SHLA) was purified from inclusion bodies and mono-pegylated super mouse leptin antagonist (SMLA) from pegylated mixture. During study it was observed that the convective interaction media (CIM) monoliths additionally discriminate between protein isoforms pegylated on different sites in 3D structure of the protein.

  19. Human-Centred Design Workshops in Collaborative Strategic Design Projects: An Educational and Professional Comparison

    Science.gov (United States)

    Liem, Andre; Sanders, Elizabeth B.-N.

    2013-01-01

    It has been found that the implementation of Human-centred Design (HCD) methods in the Fuzzy Front-End is not likely to lead to diversification in educational product planning exercises, where time lines are short and executors lack experience. Companies, interested to collaborate with Master-level Industrial Design students on strategic design…

  20. Exploring human centred approaches in market research and product development - Three case studies

    NARCIS (Netherlands)

    Steen, M.; Koning, N. de; Pikaart, A.

    2004-01-01

    How can human centred approaches in market research and product development improve the process and results of innovation? Based on case studies two recommendations are formulated: 1) use a comprehensive view on man for studying people's behaviour, needs and wishes while they use products or service

  1. Exploring human centred approaches in market research and product development - Three case studies

    NARCIS (Netherlands)

    Steen, M.; Koning, N. de; Pikaart, A.

    2004-01-01

    How can human centred approaches in market research and product development improve the process and results of innovation? Based on case studies two recommendations are formulated: 1) use a comprehensive view on man for studying people's behaviour, needs and wishes while they use products or

  2. CIM/E 模式版本管理和映射方法%CIM/E Schema of Version Management and Mapping Method

    Institute of Scientific and Technical Information of China (English)

    曹阳; 黄海峰; 梁成辉; 张鸿

    2015-01-01

    随着智能电网的建设,各类智能电网信息系统呈现分布式和异构的特点,要求通过提升信息系统的互操作能力来促进智能电网信息的共享和交互。文中以提升基于电网通用模型描述规范(CIM/E)的智能电网模型信息互操作能力为目标,分析 CIM/E 类定义模板的构成及其对 CIM/E数据的约束、CIM/E 模式扩展方式,研究建立 CIM/E 模式版本管理及 CIM/E 与公共信息模型(CIM)的模式映射体系,实现了电网模型信息互操作中 CIM/E 模式的统一管理及面向应用的灵活扩展。通过基于实际案例的 CIM/E 与 CIM/XML 互转,验证了 CIM/E 模式版本管理和模式映射的有效性,保证了 CIM/E 模式与不断演进的 CIM 版本同步的能力,进一步推动了 CIM/E 标准的国际化推广。%With the development of smart grids,all kinds of smart grid information systems appear to be distributed and heterogeneous,making it necessary to facilitate smart grid information sharing and interaction by enhancing the interoperability of information systems.Aimed at improving the interoperability of CIM/E based smart grid model information,the structure of CIM/E template and its constraints on data and the expansion mode of CIM/E schema are analyzed.And CIM/E schema version management as well as the mapping system between CIM/E and CIM RDF schema is established,while the control and application-oriented flexible expansion of CIM/E schema used in grid model information interoperability is achieved.The effectiveness of CIM/E schema version management and schema mapping is validated through actual mutual conversion between CIM/E and CIM/XML,the ability of synchronizing CIM/E schema with the steadily evolving CIM versions is guaranteed,and the international promotion of CIM/E standard further promoted.

  3. The common information model CIM IEC 61968/61970 and 62325 : a practical introduction to the CIM

    CERN Document Server

    Uslar, Mathias; Rohjans, Sebastian; Trefke, Jörn; Vasquez Gonzalez, Jose Manuel

    2012-01-01

    Within the Smart Grid, the combination of automation equipment, communication technology and IT is crucial. Interoperability of devices and systems can be seen as the key enabler of smart grids. Therefore, international initiatives have been started in order to identify interoperability core standards for Smart Grids.   IEC 62357, the so called Seamless Integration Architecture, is one of these very core standards, which has been identified by recent Smart Grid initiatives and roadmaps to be essential for building and managing intelligent power systems. The Seamless Integration Architecture provides an overview of the interoperability and relations between further standards from IEC TC 57 like the IEC 61970/61968: Common Information Model - CIM.   CIM has proven to be a mature standard for interoperability and engineering; consequently, it is a cornerstone of the IEC Smart Grid Standardization Roadmap. This book provides an overview on how the CIM developed, in which international projects and roadmaps is h...

  4. Applying human factors to the design of control centre and workstation of a nuclear reactor

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Isaac J.A. Luquetti dos; Carvalho, Paulo V.R.; Goncalves, Gabriel de L., E-mail: luquetti@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Souza, Tamara D.M.F.; Falcao, Mariana A. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Dept. de Desenho Industrial

    2013-07-01

    Human factors is a body of scientific factors about human characteristics, covering biomedical, psychological and psychosocial considerations, including principles and applications in the personnel selection areas, training, job performance aid tools and human performance evaluation. Control Centre is a combination of control rooms, control suites and local control stations which are functionally related and all on the same site. Digital control room includes an arrangement of systems, equipment such as computers and communication terminals and workstations at which control and monitoring functions are conducted by operators. Inadequate integration between control room and operators reduces safety, increases the operation complexity, complicates operator training and increases the likelihood of human errors occurrence. The objective of this paper is to present a specific approach for the conceptual and basic design of the control centre and workstation of a nuclear reactor used to produce radioisotope. The approach is based on human factors standards, guidelines and the participation of a multidisciplinary team in the conceptual and basic phases of the design. Using the information gathered from standards and from the multidisciplinary team, an initial sketch 3D of the control centre and workstation are being developed. (author)

  5. Comprehensive Instructional Management System (CIMS)--Mathematics, 1988-89.

    Science.gov (United States)

    Guerrero, Frank; And Others

    The Comprehensive Instructional Management System (CIMS) Mathematics project is a teacher-developed mathematics curriculum for kindergarten through grade seven. The 1988-89 evaluation focused on (1) the operation and impact of the program in sample of five districts, chosen to provide diverse models of the computer management system, (2) the…

  6. Implementing Continuous Improvement Management (CIM) in the Public Schools.

    Science.gov (United States)

    Borgers, William E.; Thompson, Tommy A.

    This book traces the restructuring of a Texas school district that moved from management by coercion to continuous improvement for quality. In 1990, the Dickinson Independent School District (Texas) began implementation of Continuous Improvement Management (CIM), based on the teachings of W. Edwards Deming, William Glasser, and J. M. Juran.…

  7. CIM-Einführungsstrategie für kleinere Betriebe

    OpenAIRE

    2008-01-01

    Aus den Veröffentlichungen über CIM-Projekte geht immer häufiger hervor, dass der von den Anbietern vertretene hohe Anspruch einer umfassenden CIM-Anwendung und die Ergebnisse durchgeführter CIM-Realisierungen in der Praxis nicht übereinstimmen. Es wäre jedoch falsch, aufgrund dieser Beobachtungen die CIM-Strategie als solche in Frage zu stellen. Der Ausweg aus diesem Missstand ist vielmehr über geeignete CIM-Einführungsstrategien zu suchen.

  8. A human post-mortem brain model for the standardization of multi-centre MRI studies.

    Science.gov (United States)

    Droby, Amgad; Lukas, Carsten; Schänzer, Anne; Spiwoks-Becker, Isabella; Giorgio, Antonio; Gold, Ralf; De Stefano, Nicola; Kugel, Harald; Deppe, Michael; Wiendl, Heinz; Meuth, Sven G; Acker, Till; Zipp, Frauke; Deichmann, Ralf

    2015-04-15

    Multi-centre MRI studies of the brain are essential for enrolling large and diverse patient cohorts, as required for the investigation of heterogeneous neurological and psychiatric diseases. However, the multi-site comparison of standard MRI data sets that are weighted with respect to tissue parameters such as the relaxation times (T1, T2) and proton density (PD) may be problematic, as signal intensities and image contrasts depend on site-specific details such as the sequences used, imaging parameters, and sensitivity profiles of the radiofrequency (RF) coils. Water or gel phantoms are frequently used for long-term and/or inter-site quality assessment. However, these phantoms hardly mimic the structure, shape, size or tissue distribution of the human brain. The goals of this study were: (1) to validate the long-term stability of a human post-mortem brain phantom, performing quantitative mapping of T1, T2, and PD, and the magnetization transfer ratio (MTR) over a period of 18months; (2) to acquire and analyse data for this phantom and the brain of a healthy control (HC) in a multi-centre study for MRI protocol standardization in four centres, while conducting a voxel-wise as well as whole brain grey (GM) and white matter (WM) tissue volume comparison. MTR, T2, and the quotient of PD in WM and GM were stable in the post-mortem brain with no significant changes. T1 was found to decrease from 267/236ms (GM/WM) to 234/216ms between 5 and 17weeks post embedment, stabilizing during an 18-month period following the first scan at about 215/190ms. The volumetric measures, based on T1-weighted MP-RAGE images obtained at all participating centres, revealed inter- and intra-centre variations in the evaluated GM and WM volumes that displayed similar trends in both the post-mortem brain as well as the HC. At a confidence level of 95%, brain regions such as the brainstem, deep GM structures as well as boundaries between GM and WM tissues were found to be less reproducible than

  9. The experience of two European preimplantation genetic diagnosis centres on human leukocyte antigen typing.

    Science.gov (United States)

    Van de Velde, Hilde; De Rycke, Martine; De Man, Caroline; De Hauwere, Kim; Fiorentino, Francesco; Kahraman, Semra; Pennings, Guido; Verpoest, Willem; Devroey, Paul; Liebaers, Inge

    2009-03-01

    Two European centres report on human leukocyte antigen (HLA) typing of preimplantation embryos for haematopoietic stem cell (HSC) transplantation: 'UZ Brussel' in Brussels and 'Genoma' in Rome. Both centres have 6 years' experience with technical and clinical aspects of this type of genetic analysis on single blastomeres. Both centres apply a similar technique for preimplantation HLA typing using short tandem repeats linked to the HLA locus in multiplex PCR for haplotyping. At present, a conclusive HLA diagnosis could be assured in 92.8% and 90.3% of the embryos at UZ Brussel and at Genoma, respectively. The implantation rates were 32.4% and 28.2%, respectively, and the birth rates per cycle were 9.4% and 18.6%, respectively. The HLA programme at UZ Brussel and at Genoma resulted in the birth of 9 babies and 3 successful HSC transplantations, and 42 babies and 7 successful HSC transplantations, respectively, so far. Drastic embryo selection for preimplantation HLA typing (in theory 1/4 for HLA, 1/8 for HLA in combination with sexing for X-linked recessive diseases, 3/16 for HLA in combination with autosomal recessive disorders) resulted overall in the birth of 51 babies (15.9% live birth rate per started cycle) in two European centres.

  10. Centre-surround organization of fast sensorimotor integration in human motor hand area

    DEFF Research Database (Denmark)

    Dubbioso, Raffaele; Raffin, Estelle; Karabanov, Anke

    2017-01-01

    Using the short-latency afferent inhibition (SAI) paradigm, transcranial magnetic stimulation (TMS) of the primary motor hand area (M1HAND) can probe how sensory input from limbs modulates corticomotor output in humans. Here we applied a novel TMS mapping approach to chart the spatial representat...... in M1HAND. Like homotopic SAI, heterotopic SAF was somatotopically expressed in M1HAND. Together, the results provide first-time evidence that fast sensorimotor integration involves centre-inhibition and surround-facilitation in human M1HAND....

  11. Human-centred methods in the design of an e-health solution for patients undergoing weight loss treatment

    DEFF Research Database (Denmark)

    Das, Anita; Svanæs, Dag

    2013-01-01

    Background and objective Patients undergoing weight loss treatment require follow-up as part of the treatment process. E-health solutions may be used for this purpose. We have used an iterative design approach to develop a patient-centred e-health solution for patients undergoing weight loss...... in the design process. Our findings imply that involving stakeholders separately during specific human-centred activities is important in order to capture subtle, but critical aspects of the users’ requirements. Conclusion Applying human-centred methods in the design of e-health solutions requires...

  12. Confidence Interval Methodology for Ratio Means (CIM4RM)

    Science.gov (United States)

    2010-08-01

    is the combined effort of bootstrapping and creativity in constructing CLs around ratio means. CIM4RM was tested in many ratio mean applications and...for vehicle or repair period man - hours Man-hours per vehicle or repair MR: Estimated maintenance ratio for i th BSS adj MRt Weighted estimated...assumptions on the distributions) and creativity to compute approximate confidence intervals for a ratio mean metric. The bootstrap-t approach is very

  13. Human Centred Design Considerations for Connected Health Devices for the Older Adult

    Directory of Open Access Journals (Sweden)

    Richard P. Harte

    2014-06-01

    Full Text Available Connected health devices are generally designed for unsupervised use, by non-healthcare professionals, facilitating independent control of the individuals own healthcare. Older adults are major users of such devices and are a population significantly increasing in size. This group presents challenges due to the wide spectrum of capabilities and attitudes towards technology. The fit between capabilities of the user and demands of the device can be optimised in a process called Human Centred Design. Here we review examples of some connected health devices chosen by random selection, assess older adult known capabilities and attitudes and finally make analytical recommendations for design approaches and design specifications.

  14. The Training and Culture Strategies in the CIMS Subject of China 863 Program(1986-2000)

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Manpower is a key factor for the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and culture strategies. This paper is mainly about the training and culture strategies such as to pay attention to the training and the practice of the technical team, and to form a fine CIMS culture.

  15. Determination of platinum surface contamination in veterinary and human oncology centres using inductively coupled plasma mass spectrometry

    NARCIS (Netherlands)

    Janssens, T.; Brouwers, E. E M; de Vos, J. P.; de Vries, N.; Schellens, J. H M; Beijnen, J. H.

    2015-01-01

    The objective of this study was to determine the surface contamination with platinum-containing antineoplastic drugs in veterinary and human oncology centres. Inductively coupled plasma mass spectrometry was used to measure platinum levels in surface samples. In veterinary and human oncology

  16. User experience in libraries applying ethnography and human-centred design

    CERN Document Server

    Borg, Matt

    2016-01-01

    Modern library services can be incredibly complex. Much more so than their forebears, modern librarians must grapple daily with questions of how best to implement innovative new services, while also maintaining and updating the old. The efforts undertaken are immense, but how best to evaluate their success? In this groundbreaking new book from Routledge, library practitioners, anthropologists, and design experts combine to advocate a new focus on User Experience (or UX ) research methods. Through a combination of theoretical discussion and applied case studies, they argue that this ethnographic and human-centred design approach enables library professionals to gather rich evidence-based insights into what is really going on in their libraries, allowing them to look beyond what library users say they do to what they actually do. Edited by the team behind the international UX in Libraries conference, "User Experience in Libraries" will ignite new interest in a rapidly emerging and game-changing area of resear...

  17. CIM (Computer Integrated Manufacturing) in Higher Education: A Partnership with IBM.

    Science.gov (United States)

    Andrews, Hans A.; Allen, John

    1992-01-01

    Discusses Illinois Valley Community College's selection as 1 of 48 community colleges operating technology transfer and demonstration centers for computer-integrated manufacturing (CIM) in the IBM-CIM in Higher Education Alliance. Reviews local industry involvement, curriculum development, faculty training, deliverables, and the prognosis for the…

  18. Comprehensive Instructional Management System (CIMS) Communication Arts 1985-86. OEA Evaluation Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn. Office of Educational Assessment.

    Using both qualitative and quantitative data, the Office of Educational Assessment/Instructional Support Unit evaluated the 1985-1986 New York City Board of Education's Comprehensive Instructional Management Systems-Communication Arts (CIMS-CA) Project. The 1985-1986 CIMS-CA aimed to (1) implement an integrated communication arts program for…

  19. CIM Academy Summer School: A Report of the Evaluation of the 1999 Summer School.

    Science.gov (United States)

    Mitchell, Stephanie; King, Fredrick; Anderson, Gena

    Students in the Portland, Oregon, public schools who achieve the state standards for grade 10 receive a Certificate of Initial Mastery (CIM) to document their achievement. Students who do not meet the standards may continue to be tested throughout their high school years, but they may receive a diploma without achieving a CIM. To offer additional…

  20. Enablers of the successful implementation of CIM in small and medium enterprises: an empirical analysis

    Science.gov (United States)

    Marri, H. B.; Gunasekaran, Angappa

    2001-10-01

    Small and Medium Enterprises (SMEs) play an important role in the national economy. Since manufacturing has become global, the competition is high among manufacturing/service industries to provide quality goods and services at competitive prices. Computer Integrated Manufacturing (CIM) is a generic term for a group of manufacturing technologies that combine both scope and scale capabilities that are making fundamental changes to manufacturing industry. The enablers of CIM play an important role in the implementation of CIM by SMEs to compete in the global market. Considering the importance of enablers of the successful implementation of CIM, the critical success factors for the implementation of CIM in SMEs have been identified with the help of an empirical study conducted with British SMEs.

  1. Application of two types of CIM tube column for purification of microbial enzymes.

    Science.gov (United States)

    Isobe, Kimiyasu; Kawakami, Yoshimitsu

    2005-02-11

    Chromatography conditions for two types of convection interaction media (CIM) tube monolithic column, DEAE-8 and C4-8, were investigated using three enzymes from different microorganisms. The enzymes were adsorbed on a CIM DEAE-8 tube column under the same conditions as conventional DEAE columns. The CIM C4-8 tube column required a high concentration of ammonium sulfate compared to the conventional C4 column for adsorbing the enzymes. The separation of enzymes on the CIM tube column chromatography was not affected at flow rates between 0.15 and 1.25 volumes of the column per min. Both columns were successfully applied to the purification of enzymes from crude enzyme solution. Thus, both CIM tube monolithic columns proved useful in greatly reducing the purification time, and could be used at any stage of enzyme purification.

  2. CIM-EARTH: Community Integrated Model of Economic and Resource Trajectories for Humankind

    Science.gov (United States)

    Foster, I.; Elliott, J.; Munson, T.; Judd, K.; Moyer, E. J.; Sanstad, A. H.

    2010-12-01

    We report here on the development of an open source software framework termed CIM-EARTH that is intended to aid decision-making in climate and energy policy. Numerical modeling in support of evaluating policies to address climate change is difficult not only because of inherent uncertainties but because of the differences in scale and modeling approach required for various subcomponents of the system. Economic and climate models are structured quite differently, and while climate forcing can be assumed to be roughly global, climate impacts and the human response to them occur on small spatial scales. Mitigation policies likewise can be applied on scales ranging from the better part of a continent (e.g. a carbon cap-and-trade program for the entire U.S.) to a few hundred km (e.g. statewide renewable portfolio standards and local gasoline taxes). Both spatial and time resolution requirements can be challenging for global economic models. CIM-EARTH is a modular framework based around dynamic general equilibrium models. It is designed as a community tool that will enable study of the environmental benefits, transition costs, capitalization effects, and other consequences of both mitigation policies and unchecked climate change. Modularity enables both integration of highly resolved component sub-models for energy and other key systems and also user-directed choice of tradeoffs between e.g. spatial, sectoral, and time resolution. This poster describes the framework architecture, the current realized version, and plans for future releases. As with other open-source models familiar to the climate community (e.g. CCSM), deliverables will be made publicly available on a regular schedule, and community input is solicited for development of new features and modules.

  3. Studying human-automation interactions: methodological lessons learned from the human-centred automation experiments 1997-2001

    Energy Technology Data Exchange (ETDEWEB)

    Massaiu, Salvatore; Skjerve, Ann Britt Miberg; Skraaning, Gyrd Jr.; Strand, Stine; Waeroe, Irene

    2004-04-15

    This report documents the methodological lessons learned from the Human Centred Automation (HCA) programme both in terms of psychometric evaluation of the measurement techniques developed for human-automation interaction study, and in terms of the application of advanced statistical methods for analysis of experiments. The psychometric evaluation is based on data from the four experiments performed within the HCA programme. The result is a single-source reference text of measurement instruments for the study of human-automation interaction, part of which were specifically developed by the programme. The application of advanced statistical techniques is exemplified by additional analyses performed on the IPSN-HCA experiment of 1998. Special importance is given to the statistical technique Structural Equation Modeling, for the possibility it offers to advance, and empirically test, comprehensive explanations about human-automation interactions. The additional analyses of the IPSN-HCA experiment investigated how the operators formed judgments about their own performance. The issue is of substantive interest for human automation interaction research because the operators' over- or underestimation of their own performance could be seen as a symptom of human-machine mismatch, and a potential latent failure. These analyses concluded that it is the interplay between (1) the level of automation and several factors that determines the operators' bias in performance self-estimation: (2) the nature of the task, (3) the level of scenario complexity, and (4) the level of trust in the automatic system. A structural model that expresses the interplay of all these factors was empirically evaluated and was found able to provide a concise and elegant explanation of the intricate pattern of relationships between the identified factors. (Author)

  4. A Frame Based Architecture for Information Integration in CIMS

    Institute of Scientific and Technical Information of China (English)

    吴信东

    1992-01-01

    This paper foumulates and architecture for information integration in computer integrated manufacturing systems(CIMS).The architecture takes the frame structure as single link among applications and between applications and physical storage.All the advantages in form features based intgrated systems can be found in the frame-based architecture as the frame structrue here takes from features as its primitives.But other advantage,e.g.,default knowledge and dynamic domain knowledge can be attached to frames and the frame structure is easy to be changed and extended,which cannot be found ing form reatures based systems,can also be showed in frame based architectures as the frame structure is a typical knowledge representation scheme in artificial intelligence and many researches and interests have put on it.

  5. DISCUTINDO CITY INFORMATION MODELING (CIM E CONCEITOS CORRELATOS

    Directory of Open Access Journals (Sweden)

    Arivaldo Leão de Amorim

    2015-11-01

    Full Text Available Este artigo discute o paradigma City Information Modeling (CIM a partir de uma abordagem ampla, considerando um viés teórico e conceitual deste e de outros termos relacionados. O CIM tem sido apontado por alguns autores como uma extensão do conceito de BIM para o espaço urbano. Contudo, face às características da cidade em relação à edificação isolada e à profusão de conceitos ora em uso, algumas questões precisam ser aprofundadas. Estes conceitos estão intimamente relacionados, apresentando algum tipo de sobreposição, e talvez por isto, sejam confundidos. Assim, pretende-se ampliar a discussão sobre esses conceitos, contribuindo para a utilização dos mesmos e avançando no estabelecimento de uma conceituação e terminologias que facilitem o desenvolvimento das aplicações e a adoção das tecnologias nas práticas relativas ao planejamento, à gestão e ao monitoramento da cidade. Não e tem a pretensão de esgotar o tema, seja pela vastidão das questões envolvidas, seja ainda pelo reduzido espaço a para discussão das mesmas, mas principalmente, porque estas questões estão “em aberto”, sendo objeto de discussões e controvérsias.

  6. [Human exposures to veterinary medicines reported to the Poisons Information Centre Erfurt from 2003 to 2012].

    Science.gov (United States)

    Hentschel, H; Prasa, D; Bergmann, I; Enden, G; Frimlova, G; Just, S; Plenert, B; Stürzebecher, A; Deters, M

    2014-02-01

    The purpose of this study was to get information on all human exposures to veterinary medicines (HEVM) reported to the Poisons Information Centre (PIC) over a 10-year period. A retrospective analysis of all HEVM was undertaken and a comparison was made to all human exposures (HE) registered by the PIC from the beginning of 2003 to the end of 2012 according to frequencies, circumstances of exposure, symptom severity, age groups, and substances involved in HEVM. In total, 389 cases of HEVM with 409 veterinary medicines were registered (0.30% of all HE, 360 monoexposures). The relative frequency of children and adults in HEVM (children: 52.4%, adults: 46.0%) and all HE (children: 48.7%, adults 48.7%) was the same with significant (pveterinary medicines (ATCvet) in HEVM were antiparasitic substances, insecticides and repellents (n=185), substances for the nervous system (n=48), substances for the cardiovascular system (n=35), and immunologicals (n=35). HEVM mostly resulted in no or mild symptoms (83.8%) and rarely in moderate (10/389, 2.6%) or even severe symptoms (5/389, 1.3%). In 4 of 5 cases of HEVM with severe symptoms, veterinary surgeons used products for animal euthanasia (n=3) or methadone (n=1). Once, self-medication with anthelmintics for several days by a goatherd resulted in transient blindness. In comparison to other HE, HEVM are rare. Most accidental HEVM in laymen result only in none to mild symptoms. If veterinary surgeons, however, swallow or inject products for animal euthanasia or opioids in suicidal intention, severe symptoms can be expected. © Georg Thieme Verlag KG Stuttgart · New York.

  7. Public space patterns: Towards a CIM standard for urban public space

    NARCIS (Netherlands)

    Montenegro, N.; Beirao, J.N.; Duarte, J.P.

    2011-01-01

    This paper describes public space patterns (PSP) used as basic elements of the City Information Modelling (CIM) model proposed within a larger research project that aims to develop an urban design support tool.

  8. Study on the integration approaches to CAD/CAPP/FMS in garment CIMS

    Science.gov (United States)

    Wang, Xiankui; Tian, Wensheng; Liu, Chengying; Li, Zhizhong

    1995-08-01

    Computer integrated manufacturing system (CIMS), as an advanced methodology, has been applied in many industry fields. There is, however, little research on the application of CIMS in the garment industry, especially on the integrated approach to CAD, CAPP, and FMS in garment CIMS. In this paper, the current situations of CAD, CAPP, and FMS in the garment industry are discussed, and information requirements between them as well as the integrated approaches are also investigated. The representation of the garments' product data by the group technology coding is proposed. Based on the group technology, a shared data base as an integration element can be constructed, which leads to the integration of CAD/CAPP/FMS in garment CIMS.

  9. Public space patterns: Towards a CIM standard for urban public space

    NARCIS (Netherlands)

    Montenegro, N.; Beirao, J.N.; Duarte, J.P.

    2011-01-01

    This paper describes public space patterns (PSP) used as basic elements of the City Information Modelling (CIM) model proposed within a larger research project that aims to develop an urban design support tool.

  10. The Elite Strategies in the CIMS Subject of China 863 Program(1986-2000)

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Manpower is the key factor to the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and culture strategies. This paper is mainly about the elite strategies such as to discover the talents, to cultivate the elites and to establish the mechanism for the expert groups to work in team, echelon and vigor.

  11. Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway.

    Science.gov (United States)

    Bergmann, Frank; Singh, Sandhya; Michel, Sara; Kahlert, Christoph; Schirmacher, Peter; Helmke, Burkhard; Von Knebel Doeberitz, Magnus; Kloor, Matthias; Bläker, Hendrik

    2010-12-01

    Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma. Recent studies have demonstrated aberrant CpG island methylation (CIM) in chronic inflammation, aging and cancer. We hypothesized that CIM may link CD to small bowel carcinogenesis. We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa. The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin. A high level CIM/MSI phenotype was found in all of the 3 CD-associated carcinomas and was associated with loss of MLH1 expression due to hypermethylation of the MLH1 promoter. This phenotype was noted in only 2 of the 20 investigated non-CD-associated carcinomas. Low-level CIM was already detectable in 9 of the 12 non-neoplastic mucosa samples of CD patients and in non-CD-associated carcinomas of elderly patients. In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis. The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.

  12. Purification of ß-glucosidases from Pichia etchellsii using CIM monolith columns.

    Science.gov (United States)

    Gaonkar, Roopa K; Mishra, Saroj; Vijayalakshmi, M A

    2011-05-01

    β-Glucosidases (EC 3.2.1.21) are industrially important glycosyl hydrolases used for cellulose saccharification as well as for synthesis of glyco-conjugates. Crystal structure of only one β-glucosidase of family 3 of the glycosyl hydrolase families is available due to difficulty in purification of these closely related enzymes from a given source. Multiple steps used during purification result in low yield, making it difficult to study their properties. Conditions for purification of two closely related β-glucosidases (BGL I and BGL II) of family 3 from Pichia etchellsii were investigated in this study. Two weak anion exchange columns convective interaction media-diethyl amino ethyl (CIM-DEAE) and CIM-ethylenediamine (CIM-EDA) were used for this purpose. The results obtained at 0.34 ml disk (CIM-DEAE) level were scaled up to 8 ml CIM-DEAE tube column wherein BGL I and BGL II were separated from the major contaminants in the cell-free extract. The recovered enzymes were completely resolved in the second step using CIM-EDA. A final specific activity of 9,180 IU/mg and 2,345.3 IU/mg was achieved for BGL I and BGL II respectively with an overall yield of 33%. The system should be applicable to resolution of other closely related enzymes from this family.

  13. Temporal properties of centre-surround interactions in human motion perception

    NARCIS (Netherlands)

    Perge, J.A.; Kanai, R.; Wezel, R.J.A. van; Lankheet, M.J.M.

    2003-01-01

    A recent electrophysiological study revealed that the response to the antagonistic surround of macaque area MT receptive fields is delayed (15 - 20 ms) relative to the centre (Perge et al, 2002 Investigative Ophthalmology & Visual Science 43 E-Abstract 3931). We investigated whether this phenomenon,

  14. Evaluation of the carbapenem inactivation method (CIM) for detecting carbapenemase activity in enterobacteria.

    Science.gov (United States)

    Aguirre-Quiñonero, A; Cano, M E; Gamal, D; Calvo, J; Martínez-Martínez, L

    2017-07-01

    The objective of this study was to evaluate the accuracy of the CIM test in the detection of carbapenemase activity in 124 strains of Enterobacteriaceae. A panel of 124 previously characterized Enterobacteriaceae was tested: 77 strains producing the following carbapenemase families: KPC (n = 14), GES (n = 22), NDM (n = 19), VIM (n = 4), IMP (n = 4) and OXA-48 (n = 14) and 47 non-carbapenemase producers. For the CIM method, an active susceptibility meropenem disc was exposed to a bacterial suspension of a test strain; when a carbapenemase is produced, the antibiotic is inactivated allowing uninhibited growth of an indicator strain after overnight incubation. A clear inhibition zone (≥20 mm) was considered indicative of no-carbapenemase activity. All KPC, NDM, VIM, IMP or OXA-48 producing strains were unequivocally detected with the CIM test. CIM false negative results were obtained with eleven Enterobacter cloacae producing GES-6. Two other E. cloacae not producing carbapenemase (one with SHV-12, one hyperproducing AmpC) were positive by the test. The sensitivity and specificity of the assay compared to those of molecular methods were 85.7% and 95.7%, respectively. The CIM method proved to be inexpensive and easy to interpret. It provided less than optimal results in the detection of GES-6 activity. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Client Centred Desing

    DEFF Research Database (Denmark)

    Ørngreen, Rikke; Nielsen, Janni; Levinsen, Karin

    2008-01-01

    In this paper we argue for the use of Client Centred preparation phases when designing complex systems. Through Client Centred Design human computer interaction can extend the focus on end-users to alse encompass the client's needs, context and resources....

  16. The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM).

    Science.gov (United States)

    Ogilvie, Hannah; Larsson, Lars

    2014-05-30

    The muscle wasting and loss of specific force associated with Critical Illness Myopathy (CIM) is, at least in part, due to a preferential loss of the molecular motor protein myosin. This acquired myopathy is common in critically ill immobilized and mechanically ventilated intensive care patients (ICU). There is a growing understanding of the mechanisms underlying CIM, but the role of nutritional factors triggering this serious complication of modern intensive care remains unknown. This study aims at establishing the effect of nutritional status in the pathogenesis of CIM. An experimental ICU model was used where animals are mechanically ventilated, pharmacologically paralysed post-synaptically and extensively monitored for up to 14 days. Due to the complexity of the experimental model, the number of animals included is small. After exposure to this ICU condition, animals develop a phenotype similar to patients with CIM. The results from this study show that the preferential myosin loss, decline in specific force and muscle fiber atrophy did not differ between low vs. eucaloric animals. In both experimental groups, passive mechanical loading had a sparing effect of muscle weight independent on nutritional status. Thus, this study confirms the strong impact of the mechanical silencing associated with the ICU condition in triggering CIM, overriding any potential effects of caloric intake in triggering CIM. In addition, the positive effects of passive mechanical loading on muscle fiber size and force generating capacity was not affected by the nutritional status in this study. However, due to the small sample size these pilot results need to be validated in a larger cohort.

  17. Evaluation of closed incision management with negative pressure wound therapy (CIM): hematoma/seroma and involvement of the lymphatic system.

    Science.gov (United States)

    Kilpadi, Deepak V; Cunningham, Mark R

    2011-01-01

    The objective of this porcine study was to evaluate the effect of closed incision management with negative pressure wound therapy (CIM) on hematoma/seroma formation, fluid removal into the CIM canister, and involvement of the lymphatic system. In each swine (n = 8), two sets of ventral contralateral subcutaneous dead spaces with overlying sutured incisions were created. Stable isotope-labeled nanospheres were introduced into each subcutaneous dead space. Each contralateral incision was assigned to CIM (continuous -125 mmHg negative pressure) and control (semipermeable film dressing), respectively. Following 4 days of therapy, hematoma/seroma was weighed, total fluid volume in canisters was measured, five pre-identified lymph nodes were harvested, and five key organs were biopsied. There was 25 ± 8 g (standard error [SE]) (63%) less hematoma/seroma in CIM sites compared to control sites (p = 0.002), without any fluid collection in the CIM canister. In lymph nodes, there were ∼60 μg (∼50%) more 30- and 50-nm nanospheres from CIM sites than from control sites (p = 0.04 and 0.05, respectively). There was significantly greater nanosphere incidence from CIM sites than from control sites in lungs, liver, and spleen (p CIM significantly decreased hematoma/seroma levels without fluid collection in the canister, which may be explained by increased lymph clearance.

  18. Non-RF Chain of Custody Item Monitor (CoCIM) User Manual.

    Energy Technology Data Exchange (ETDEWEB)

    Brotz, Jay Kristoffer [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wade, James Rokwel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Schwartz, Steven Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-06-01

    This User Manual contains a description of the wired and infrared (IR) variants of the Chain of Custody Item Monitor (CoCIM), the Coordinator for reading stored messages, and the inspector Message Viewer user interface (UI) software, as well as instructions for use. This manual does not include descriptions or use instructions for the radio frequency (RF) variant of the CoCIM. The intended audience is planners and participants in treaty verification exercises where chain of custody (CoC) elements are required.

  19. Application of Convective Interaction Media (CIM) disk monolithic columns for fast separation and monitoring of organic acids.

    Science.gov (United States)

    Vodopivec, M; Podgornik, A; Berovic, M; Strancar, A

    2000-11-01

    The separation of organic acids on the anion-exchange monolithic support, commercially available as Convective Interaction Media (CIM), is presented in this study. It is demonstrated that citric, isocitric, pyruvic, fumaric, malic, and alpha-ketoglutaric acid can be successfully separated using a CIM monolithic column of suitable user-adjustable length. The effect of the mobile phase composition on the separation is investigated. CIM monolithic columns of adjustable length from 3 to 18 mm are compared regarding the resolution and the back pressure. It is shown that the CIM monolithic column of 12 mm in length enables a good separation of all six organic acids within 3 min and exhibits a linear dependence of back pressure versus flow rate. The resolution and the dynamic binding capacity are found to be flow-unaffected. A filtrated sample of bioprocess supernatant is analyzed without previous pretreatment, which indicates the possibility of online monitoring of small molecules during the bioprocess using CIM monolithic columns.

  20. The Development of CIMS and the Actuality of CIMS Application in China%CIMS的发展及其在我国的应用现状

    Institute of Scientific and Technical Information of China (English)

    朱焕立; 刘进宝

    2003-01-01

    介绍了CIMS的产生背景、含义及在我国的发展,指出我国863/CIMS主题实施的CIM/CIMS内涵;总结出了CIMS技术体系,通过介绍863/CIMS应用示范工程概况阐述了CIMS在我国的应用现状.

  1. Use of plasma human herpesvirus-8 viral load measurement: evaluation of practice in three UK HIV treatment centres.

    Science.gov (United States)

    Nugent, D B; Webster, D; Mabayoje, D; Chung, E; El Bouzidi, K; O'Sullivan, A; Ainsworth, J; Miller, R F

    2017-02-01

    A retrospective audit of plasma human herpesvirus-8 (HHV-8) viral load testing was performed in three HIV treatment centres over 24 months. Reasons for testing (360 tests) were: symptoms of systemic inflammatory response syndrome (SIRS) (fever, lymphadenopathy and raised inflammatory markers); monitoring in known HHV-8 pathology other than Kaposi sarcoma (KS); investigation of known/suspected KS, and other/no reason. Of patients with multicentric Castleman disease (MCD), 14/16 (88%) had detectable plasma HHV-8, as did 27/45 (60%) with biopsy proven or clinically confirmed KS, and 6/19 (32%) with lymphoma. Neither of the two patients with MCD and no detectable HHV-8 had SIRS symptoms at the time of the test. There was wide variation between centres in the indications prompting HHV-8 testing, with a more conservative approach resulting in a higher proportion of positive results. Measuring plasma HHV-8 in the absence of SIRS symptoms, established HHV-8 disease monitoring, or confirmed/suspected KS is unlikely to yield detectable HHV-8 thus allowing potential cost savings.

  2. Affinity purification and enzymatic cleavage of inter-alpha inhibitor proteins using antibody and elastase immobilized on CIM monolithic disks.

    Science.gov (United States)

    Lim, Yow-Pin; Josic, Djuro; Callanan, Helen; Brown, Jeanne; Hixson, Douglas C

    2005-02-11

    Epoxy-activated monolithic CIM disks seem to be excellent supports for immobilization of protein ligands. The potential use of enzymes, immobilized on monolithic disks for rapid preparative cleavage proteins in solution was investigated. Digestion of complex plasma proteins was demonstrated by using inter-alpha inhibitors with elastase, immobilized on epoxy-activated CIM disks. Recently, a monoclonal antibody against human inter-alpha inhibitor proteins (MAb 69.31) was developed. MAb 69.31 blocks the inhibitory activity of inter-alpha inhibitor proteins to serine proteases. These results suggest that the epitope defined by this antibody is located within or proximal to the active site of the inhibitor molecule. This antibody, immobilized on monolithic disk, was used for very rapid isolation of inter-alpha proteins. The isolated complex protein was used for enzymatic digestion and isolation of cleavage products, especially from inter-alpha inhibitor light chain to elucidate precisely the target sequence for MAb 69.31 by N-terminal amino acid sequencing. Bovine pancreatic elastase immobilized on monolithic disk cleaves inter-alpha inhibitor protein complex into small fragments which are still reactive with MAb 69.31. One of these proteolytic fragments was isolated and partially sequenced. It could be shown that this sequence is located at the beginning of two proteinase inhibitor domains of the inter-alpha inhibitor light chain (bikunin). Elastase immobilized on monolithic disk offers a simple and rapid method for preparative isolation of protease cleavage fragments. The immobilized enzyme is stable and still active after repeated runs. A partial or complete digestion can be achieved by varying the flow rate.

  3. Performance of CarbaNP and CIM tests in OXA-48 carbapenemase-producing Enterobacteriaceae.

    Science.gov (United States)

    Yıldız, Serap Süzük; Kaşkatepe, Banu; Avcıküçük, Havva; Öztürk, Şükran

    2017-03-01

    This study applied two phenotypic tests, namely "Carbapenemase Nordmann-Poirel" (CarbaNP) test and "Carbapenem Inactivation Method" (CIM), against the isolates carrying the carbapenem resistance genes. The study included 83 carbapenem-resistant Enterobacteriaceae isolates producing oxacillinase-48 (OXA-48) and 30 carbapenem-sensitive Enterobacteriaceae isolates. Out of the total isolates studied, 77 isolates (92.77%) were identified as Klebsiella pneumoniae and six isolates (7.23%) were identified as Escherichia coli by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. Polymerase chain reaction (PCR) method used to detect resistance genes found that 74 isolates (89.16%) produced OXA-48 carbapenemase, whereas nine isolates (10.84%) produced both OXA-48 and New Delhi metallo-beta-lactamase-1 (NDM-1). The isolates producing both OXA-48 and NDM-1 were found to be positive by both phenotypic tests. Among isolates carrying only blaOXA-48 gene alone, nine isolates (13.04%) for CarbaNP test and two isolates for CIM test (2.90%) displayed false negative results, respectively. The sensitivity of CarbaNP and CIM tests was found to be 89.16% and 97.59%, respectively, whereas the specificity was determined to be 100% for both tests. These findings suggest that CarbaNP and CIM tests are useful tools to identify the carbapenemase producers. Molecular methods like PCR are recommended to verify false negative tests predicted to have OXA-48 activity.

  4. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 2, Teacher. Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The major goal of the Comprehensive Instructional Management System (CIMS) for mathematics is to provide classroom teachers in New York City with a well-structured, objective-based curriculum. This second part of the manual for Level 2 includes modules for 12 topics: numbers and numeration; addition of whole numbers; subtraction of whole numbers;…

  5. CIM Academy Summer School: A Report of the Evaluation of the 2000 Summer School.

    Science.gov (United States)

    King, Fredrick; Kobak, Jared

    The Certificate of Initial Mastery (CIM) Academy summer school in Portland, Oregon, is a public school program that provides additional support to students in grades 5 through 8 who are not meeting state and district standards in reading and mathematics. Summer 2000 was the second year of this program, and this session benefited from the…

  6. Comprehensive Instructional Management Systems (CIMS)--Science 1991-92. OREA Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Research, Evaluation, and Assessment.

    The Comprehensive Instructional Management System (CIMS)-Science program is designed to support teachers in teaching the "New York State Elementary Science Syllabus." The curriculum emphasizes a hands-on inquiry approach to learning and includes an assessment component comprised of written tests and performance-based tests, designed to…

  7. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 1, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The activities in this workbook are designed to provide pupils with practice in mastering the performance objectives of the Comprehensive Instructional Management System (CIMS) in Mathematics for Level 2, Part 1, in New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. The 85…

  8. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Workbook Part 2, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The activities in this mathematics workbook are designed to provide pupils with practice in mastering the performance objectives of Level 2, Part 2, in the Comprehensive Instructional Management System (CIMS) for New York City schools. It follows the sequence of the teacher's manual, with the objective number listed on each page. The 128…

  9. Comprehensive Instructional Management System (CIMS) Science 1988-89. Evaluation Section Report.

    Science.gov (United States)

    Guerrero, Frank; And Others

    This report is designed to help teachers and supervisors in teaching the New York State Elementary Syllabus in kindergarten through grade two. The curriculum emphasized a hands-on inquiry approach, and included both science process skills and content objectives. This is a report of the Comprehensive Instructional Management System (CIMS)-Science…

  10. VTAE CIM Conference (Menomonie, Wisconsin, June 6-7, 1990). Final Report.

    Science.gov (United States)

    Lee, Howard D.

    This document reports on a workshop conducted to bring together vocational, technical, and adult education colleges and the University of Wisconsin-Stout staff members who are working with computer-integrated manufacturing (CIM). Participants discussed current program content, identified areas that need further development, and determined how…

  11. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1, Teacher, Experimental. Level 2.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The major goal of the Comprehensive Instructional Management System (CIMS) for mathematics is to provide the classroom teacher in New York City with a well-structured, objective-based curriculum. This first part of the manual for Level 2 includes varied numbers of modules for 12 topics: numbers and numeration; addition of whole numbers;…

  12. Comprehensive Instructional Management System (CIMS). A Cyclical Mathematics Curriculum. Part 1--Teacher. Experimental. Level 6. Revised.

    Science.gov (United States)

    Berman, David; And Others

    The Comprehensive Instructional Management System (CIMS) is a unified mathematics curriculum for grades K-7. The curriculum is cyclical in design, and reflects the most recent New York City and New York State guidelines. Utilizing the experience of classroom teachers, a teacher-designed curriculum was developed that includes a rich selection of…

  13. Social Shaping of CAPM/CIM and the Social System of the Company

    DEFF Research Database (Denmark)

    Clausen, Christian

    1997-01-01

    This chapter deals with the transformation of production technology (CAPM and CIM) from general visions operating in discussions at the societal level or among consultants, unions etc. through to its implementation at the company level. The shaping of technology through political and social proce...

  14. Field Measurements Of Ammonia Fluxes Above A Douglas-fir Forest In Speuld, Holland Using Chemical Ionization Mass Spectrometry (CIMS)

    Science.gov (United States)

    McGillen, M. R.; Gallagher, M. W.; Flynn, M. J.; Percival, C. J.

    2009-12-01

    Ammonia (NH3) is an important component of the atmospheric nitrogenous species on regional scales and is a major contributor to the nitrogen budget across the UK and Western Europe. It represents the major atmospheric alkaline gas and in its interaction with acidic gases such as nitric acid, leads to the formation of particulate matter (e.g., Asman, 1998). As sulphur emissions decline across Western Europe, regions of excess ammonia are becoming more widespread and ammonium nitrate aerosol is becoming a significant component of atmospheric nitrogen . NH3 is efficiently lost to the semi-natural vegetation, typical of many natural ecosystems prevalent in Western Europe. Deposition of atmospheric NH3 to ecosystems can lead to deleterious effects such as eutrophication and acidification of soils, contributing to forest decline and a decrease in biological diversity (e.g., Fangmeier et al., 1994). Ammonia measurements were performed using chemical ionization mass spectrometry (CIMS) utilizing the protonated acetone dimer as the precursor ion. NH3 flux measurements were evaluated using the eddy covariance technique at a height of 46m above ground at Speuld forest. The Speuld fieldsite is a mature plantation of Douglas-fir (Pseudotsuga menziesii), located in the centre of the Netherlands (52°13'N, 5 ° 39'E). Data was collected over a two week period (June 25th - July 8th 2009), and fluxes will be determined using the eddy covariance technique. To the authors’ knowledge, these measurements represent the only NH3 flux measurements using CIMS, indeed few studies exist that directly determine fluxes using the this technique. Eddy covariance flux measurements are the most direct way to estimate NH3 removal near the surface. Preliminary data will be presented and compared with the GRadient Ammonia High Accuracy Monitor (GRAHAM) method. References: Asman, W. A. H., Sutton, M. A., and Schjorring, J. K.: Ammonia: emission, atmospheric transport and deposition, New Phytol., 139

  15. 一种CIM模型的Java代码生成方法%Java Code Generation Method of CIM Model

    Institute of Scientific and Technical Information of China (English)

    余永忠; 王永才

    2013-01-01

    介绍一种将CIM模型转换为Java代码的方法。 CIM模型是对电力企业的对象进行建模,是进行CIM应用的基础,将CIM模型转换为Java代码是为了实用的需要。对CIM模型及EMF框架进行简要的介绍,说明CIM模型通过转换为EMF模型从而生成Java代码的方法实现,为CIM模型的落地实用化提供参考。%Introduces a method of transforming CIM model to Java code. CIM model is the model of the power enterprise, is the basis for the CIM application, the CIM model into Java code for practi-cal needs. Gives a brief introduction of CIM model and EMF framework, from the CIM model to EMF model, and generate Java code, as the reference of the CIM model application.

  16. Precision wildlife medicine: applications of the human-centred precision medicine revolution to species conservation.

    Science.gov (United States)

    Whilde, Jenny; Martindale, Mark Q; Duffy, David J

    2017-05-01

    The current species extinction crisis is being exacerbated by an increased rate of emergence of epizootic disease. Human-induced factors including habitat degradation, loss of biodiversity and wildlife population reductions resulting in reduced genetic variation are accelerating disease emergence. Novel, efficient and effective approaches are required to combat these epizootic events. Here, we present the case for the application of human precision medicine approaches to wildlife medicine in order to enhance species conservation efforts. We consider how the precision medicine revolution, coupled with the advances made in genomics, may provide a powerful and feasible approach to identifying and treating wildlife diseases in a targeted, effective and streamlined manner. A number of case studies of threatened species are presented which demonstrate the applicability of precision medicine to wildlife conservation, including sea turtles, amphibians and Tasmanian devils. These examples show how species conservation could be improved by using precision medicine techniques to determine novel treatments and management strategies for the specific medical conditions hampering efforts to restore population levels. Additionally, a precision medicine approach to wildlife health has in turn the potential to provide deeper insights into human health and the possibility of stemming and alleviating the impacts of zoonotic diseases. The integration of the currently emerging Precision Medicine Initiative with the concepts of EcoHealth (aiming for sustainable health of people, animals and ecosystems through transdisciplinary action research) and One Health (recognizing the intimate connection of humans, animal and ecosystem health and addressing a wide range of risks at the animal-human-ecosystem interface through a coordinated, collaborative, interdisciplinary approach) has great potential to deliver a deeper and broader interdisciplinary-based understanding of both wildlife and human

  17. Linagliptin Limits High Glucose Induced Conversion of Latent to Active TGFß through Interaction with CIM6PR and Limits Renal Tubulointerstitial Fibronectin.

    Directory of Open Access Journals (Sweden)

    Muralikrishna Gangadharan Komala

    Full Text Available In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4 inhibitors have been shown to be antifibrotic. We have previously shown that cation independent mannose-6-phosphate receptor (CIM6PR facilitates the conversion of latent to active transforming growth factor β1 (GFß1 in renal proximal tubular cells (PTCs and linagliptin (a DPP4 inhibitor reduced this conversion with downstream reduction in fibronectin transcription.We wanted to demonstrate that linagliptin reduces high glucose induced interaction between membrane bound DPP4 and CIM6PR in vitro and demonstrate reduction in active TGFß mediated downstream effects in a rodent model of type 1 diabetic nephropathy independent of high glycaemic levels.We used human kidney 2 (HK2 cells and endothelial nitric oxide synthase knock out mice to explore the mechanism and antifibrotic potential of linagliptin independent of glucose lowering. Using a proximity ligation assay, we show that CIM6PR and DPP4 interaction was increased by high glucose and reduced by linagliptin and excess mannose-6-phosphate (M6P confirming that linagliptin is operating through an M6P-dependent mechanism. In vivo studies confirmed these TGFß1 pathway related changes and showed reduced fibronectin, phosphorylated smad2 and phosphorylated smad2/3 (pSmad2/3 with an associated trend towards reduction in tubular atrophy, which was independent of glucose lowering. No reduction in albuminuria, glomerulosclerotic index or cortical collagen deposition was observed.Linagliptin inhibits activation of TGFß1 through a M6P dependent mechanism. However this in isolation is not sufficient to reverse the multifactorial nature of diabetic nephropathy.

  18. Trend of human brucellosis over a decade at tertiary care centre in North Karnataka

    Directory of Open Access Journals (Sweden)

    D P Patil

    2016-01-01

    Full Text Available Background: Brucellosis is an important zoonotic disease. India having a major agrarian population is expected to have a higher prevalence. However, due to lack of laboratory facility or awareness among clinicians, the disease is largely underreported. The aim of this study was to know the prevalence and trend of human brucellosis over a decade, in patients attending a teaching hospital in North Karnataka, and to understand their geographical distribution. Materials and Methods: The study was conducted from January 2006 to December 2015 at a tertiary care teaching hospital in North Karnataka. A total of 3610 serum samples were evaluated from suspected cases of brucellosis. All serum samples were initially screened by Rose Bengal plate test, and positive samples were further analysed by Serum agglutination test (SAT using standard Brucella abortus antigen from Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India. A titre above or equal to 1:80 IU/ml was considered as positive. Demographic data such as age, sex and native place of these patients were also analysed. Results: We observed that human brucellosis is present in North Karnataka. The overall seropositivity of brucellosis in suspected cases was 5.1%. The positive titres ranged from 1:80 to 163,840 IU/ml. The majority of the patients were from Gadag, Koppal and Haveri districts of North Karnataka. Conclusion: Our study confirms the presence of human brucellosis in the northern part of Karnataka. Further studies to understand the prevalence of animal brucellosis in these areas will help in implementing prevention measures.

  19. Dive Activities from Cruise Information Management System (CIMS) for Operation Deep Scope 2005 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  20. Dive Activities from Cruise Information Management System (CIMS) for Life on the Edge 2005 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  1. Dive Activities from Cruise Information Management System (CIMS) for Life on the Edge 2004 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  2. Dive Activities from Cruise Information Management System (CIMS) for Investigating the Charleston Bump 2003 - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  3. CIMS Network of Support for Technology Projects%浅谈CIMS工程网络支持技术

    Institute of Scientific and Technical Information of China (English)

    刘婷婷

    2009-01-01

    该文简述了CIMS的组成并探讨了CIMS的重要支持技术CIMS网络,分别对CIMS网络的作用和网络协议作了相应的介入,在此基础上总结了互联网机构的选择等建网技术.%The composition of CIMS and the CIMS network which is the important support technology for CIMS is discussed in this pa-per.On the basis of the intervention of the role of the CIMS network and network protocol,the network building technology such as the choice of the Intemet institutions is summed up.

  4. An analysis of socio/cultural impact of CIM on the Department of Defense and possible implementation strategy

    OpenAIRE

    Hantjis, William M.; Kelley, Donald A.

    1991-01-01

    Approved for public release; distribution is unlimited The Corporate Information Management (CIM) initiave in the Department of Defense (DoD) is an attempt to eliminate duplicate Automatic Data Processing ( ADP) systems through the standardization of functional area requirements across all DoD agencies. CIM initiative management recognized that the DoD organizational culture might impact or be impacted by such an all-encompassing initiative. The purpose of this thesis is to estima...

  5. CIM's bridge from CADD to CAM: Data management requirements for manufacturing engineering

    Science.gov (United States)

    Ford, S. J.

    1984-01-01

    Manufacturing engineering represents the crossroads of technical data management in a Computer Integrated Manufacturing (CIM) environment. Process planning, numerical control programming and tool design are the key functions which translate information from as engineered to as assembled. In order to transition data from engineering to manufacturing, it is necessary to introduce a series of product interpretations which contain an interim introduction of technical parameters. The current automation of the product definition and the production process places manufacturing engineering in the center of CAD/CAM with the responsibility of communicating design data to the factory floor via a manufacturing model of the data. A close look at data management requirements for manufacturing engineering is necessary in order to establish the overall specifications for CADD output, CAM input, and CIM integration. The functions and issues associated with the orderly evolution of computer aided engineering and manufacturing are examined.

  6. CIM's bridge from CADD to CAM: Data management requirements for manufacturing engineering

    Science.gov (United States)

    Ford, S. J.

    1984-01-01

    Manufacturing engineering represents the crossroads of technical data management in a Computer Integrated Manufacturing (CIM) environment. Process planning, numerical control programming and tool design are the key functions which translate information from as engineered to as assembled. In order to transition data from engineering to manufacturing, it is necessary to introduce a series of product interpretations which contain an interim introduction of technical parameters. The current automation of the product definition and the production process places manufacturing engineering in the center of CAD/CAM with the responsibility of communicating design data to the factory floor via a manufacturing model of the data. A close look at data management requirements for manufacturing engineering is necessary in order to establish the overall specifications for CADD output, CAM input, and CIM integration. The functions and issues associated with the orderly evolution of computer aided engineering and manufacturing are examined.

  7. Convective Interaction Media (CIM)--short layer monolithic chromatographic stationary phases.

    Science.gov (United States)

    Podgornik, Ales; Strancar, Ales

    2005-01-01

    Modern downstream processing requires fast and highly effective methods to obtain large quantities of highly pure substances. Commonly applied method for this purpose is chromatography. However, its main drawback is its throughput since purification, especially of large molecules, requires long process time. To overcome this problem several new stationary phases were introduced, among which short layer monoliths show superior properties for many applications. The purpose of this review is to give an overview about short methacrylate monolithic columns commercialised under the trademark Convective Interaction Media (CIM). Their unique properties are described from different perspectives, explaining reasons for their application on various areas. Approaches to prepare large volume methacrylate monolithic column are discussed and optimal solutions are given. Different examples of CIM monolithic column implementation are summarised in the last part of the article to give the reader an idea about their advantages.

  8. Rice Seed Priming with Picomolar Rutin Enhances Rhizospheric Bacillus subtilis CIM Colonization and Plant Growth.

    Science.gov (United States)

    Singh, Akanksha; Gupta, Rupali; Pandey, Rakesh

    2016-01-01

    The effect of rutin, a bioflavonoid on the growth and biofilm formation of Bacillus subtilis strain CIM was investigated. In addition to swimming, swarming, and twitching potentials of B. subtilis CIM (BS), one picomolar (1 pM) of rutin was also observed to boost the biofilm forming ability of the bacterium. Bio-priming of rice seeds with BS and rutin not only augmented root and shoot lengths but also the photosynthetic pigments like chlorophyll and carotenoid. Similarly, high accumulation of phenolic and flavonoid contents was observed in the leaves. Fluorescent microscopic images revealed that BS plus rutin enhanced callose deposition in the leaves. It was also established that the least formation of reactive oxygen species in BS plus rutin treated rice plants was due to higher free radicals scavenging activity and total antioxidant potential. The results highlight chemo attractant nature of BS towards rutin, which by enhancing biofilm formation and root colonization indirectly strengthened the plants' defensive state.

  9. Rice Seed Priming with Picomolar Rutin Enhances Rhizospheric Bacillus subtilis CIM Colonization and Plant Growth.

    Directory of Open Access Journals (Sweden)

    Akanksha Singh

    Full Text Available The effect of rutin, a bioflavonoid on the growth and biofilm formation of Bacillus subtilis strain CIM was investigated. In addition to swimming, swarming, and twitching potentials of B. subtilis CIM (BS, one picomolar (1 pM of rutin was also observed to boost the biofilm forming ability of the bacterium. Bio-priming of rice seeds with BS and rutin not only augmented root and shoot lengths but also the photosynthetic pigments like chlorophyll and carotenoid. Similarly, high accumulation of phenolic and flavonoid contents was observed in the leaves. Fluorescent microscopic images revealed that BS plus rutin enhanced callose deposition in the leaves. It was also established that the least formation of reactive oxygen species in BS plus rutin treated rice plants was due to higher free radicals scavenging activity and total antioxidant potential. The results highlight chemo attractant nature of BS towards rutin, which by enhancing biofilm formation and root colonization indirectly strengthened the plants' defensive state.

  10. Utilizing a Photo-Analysis Software for Content Identifying Method (CIM

    Directory of Open Access Journals (Sweden)

    Nejad Nasim Sahraei

    2015-01-01

    Full Text Available Content Identifying Methodology or (CIM was developed to measure public preferences in order to reveal the common characteristics of landscapes and aspects of underlying perceptions including the individual's reactions to content and spatial configuration, therefore, it can assist with the identification of factors that influenced preference. Regarding the analysis of landscape photographs through CIM, there are several studies utilizing image analysis software, such as Adobe Photoshop, in order to identify the physical contents in the scenes. This study attempts to evaluate public’s ‘preferences for aesthetic qualities of pedestrian bridges in urban areas through a photo-questionnaire survey, in which respondents evaluated images of pedestrian bridges in urban areas. Two groups of images were evaluated as the most and least preferred scenes that concern the highest and lowest mean scores respectively. These two groups were analyzed by CIM and also evaluated based on the respondent’s description of each group to reveal the pattern of preferences and the factors that may affect them. Digimizer Software was employed to triangulate the two approaches and to determine the role of these factors on people’s preferences. This study attempts to introduce the useful software for image analysis which can measure the physical contents and also their spatial organization in the scenes. According to the findings, it is revealed that Digimizer could be a useful tool in CIM approaches through preference studies that utilizes photographs in place of the actual landscape in order to determine the most important factors in public preferences for pedestrian bridges in urban areas.

  11. Treatment for Chiari 1 malformation (CIM): analysis of a pediatric surgical series.

    Science.gov (United States)

    Valentini, Laura; Visintini, Sergio; Saletti, Veronica; Chiapparini, Luisa; Estienne, Margherita; Solero, Carlo Lazzaro

    2011-12-01

    Children may present a peculiar picture of CIM, as syncopes and acute paraparesis. In a series of 99 children operated for CIM at FINCB there were no major surgical morbidity nor mortality. The preoperative symptoms improved more in this pediatric series than in the adult cases treated at the same institution in the same period; a reason could be the shorter duration of symptoms and another the children plasticity. An untreated nonsyndromic craniosynostosis was present in 10 cases. In our hands, the results of the limited extradural decompression were poor. In some CIM associated with psychiatric symptoms an unexpected improvement was observed after tonsilar resection. The associated Syringomyelia reduced in more than 80% of children and disappeared in a significant number. The rare associated tethered cord (5%) needed a double treatment, detethering by itself being insufficient to treat also tonsillar descent. The clinical symptoms are often more serious in children than in the adults, but the results of surgery, especially on the syrinx, are better.

  12. Reliability of functional and predictive methods to estimate the hip joint centre in human motion analysis in healthy adults.

    Science.gov (United States)

    Kainz, Hans; Hajek, Martin; Modenese, Luca; Saxby, David J; Lloyd, David G; Carty, Christopher P

    2017-03-01

    In human motion analysis predictive or functional methods are used to estimate the location of the hip joint centre (HJC). It has been shown that the Harrington regression equations (HRE) and geometric sphere fit (GSF) method are the most accurate predictive and functional methods, respectively. To date, the comparative reliability of both approaches has not been assessed. The aims of this study were to (1) compare the reliability of the HRE and the GSF methods, (2) analyse the impact of the number of thigh markers used in the GSF method on the reliability, (3) evaluate how alterations to the movements that comprise the functional trials impact HJC estimations using the GSF method, and (4) assess the influence of the initial guess in the GSF method on the HJC estimation. Fourteen healthy adults were tested on two occasions using a three-dimensional motion capturing system. Skin surface marker positions were acquired while participants performed quite stance, perturbed and non-perturbed functional trials, and walking trials. Results showed that the HRE were more reliable in locating the HJC than the GSF method. However, comparison of inter-session hip kinematics during gait did not show any significant difference between the approaches. Different initial guesses in the GSF method did not result in significant differences in the final HJC location. The GSF method was sensitive to the functional trial performance and therefore it is important to standardize the functional trial performance to ensure a repeatable estimate of the HJC when using the GSF method.

  13. Explore, Understand, Share and Show How: Four ways to use hermeneutic phenomenology to inspire human-centred creativity in engineering design

    DEFF Research Database (Denmark)

    Coxon, Ian Robert

    2014-01-01

    At our engineering research centre we have been applying hermeneutic phenomenology in a broad spectrum of projects for understanding everyday human experience. Through our work, we have experimented with and explored creative ways to 'get into' the lives of participants within the health, pharmac......At our engineering research centre we have been applying hermeneutic phenomenology in a broad spectrum of projects for understanding everyday human experience. Through our work, we have experimented with and explored creative ways to 'get into' the lives of participants within the health...... (as best we can), understanding hidden 'meaning structures' contained within them at the most primordial level, and communicating these insights experientially are the goals that drive us. In this paper we share some examples of how we have combined design thinking with hermeneutic phenomenology...

  14. Impact of marketing, information system, modularity, and low-cost solution on the implementation of CIM in SMEs

    Science.gov (United States)

    Marri, Hussain B.; McGaughey, Ronald; Gunasekaran, Angappa

    2000-10-01

    Globalization can have a dramatic impact on manufacturing sector due to the fact that the majority of establishments in this industry are small to medium manufacturing companies. The role of Small and Medium Enterprises (SMEs) in the national economy has been emphasized all over the world, considering their contribution to the total manufacturing output and employment opportunities. The lack of marketing forces to regulate the operation of SMEs has been a fundamental cause of low efficiency for a long time. Computer Integrated Manufacturing (CIM) is emerging as one of the most promising opportunities for shrinking the time delays in information transfer and reducing manufacturing costs. CIM is the architecture for integrating the engineering, marketing and manufacturing functions through information system technologies. SMEs in general have not made full use of new technologies although their investments in CIM technology tended to be wider in scale and scope. Most of the SMEs only focus on the short-term benefit, but overlook a long- term and fundamental development on applications of new technologies. With the help of suitable information systems, modularity and low cost solutions, SMEs can compete in the global market. Considering the importance of marketing, information system, modularity and low cost solutions in the implementation of CIM in SMEs, a model has been developed and studied with the help of an empirical study conducted with British SMEs to facilitate the adoption of CIM. Finally, a summary of findings and recommendations are presented.

  15. Application of Lithium Attachment Mass Spectrometry for Knudsen Evaporation and Chemical Ionisation Mass Spectrometry (KEMS, CIMS)

    Science.gov (United States)

    Bannan, Thomas; Booth, A. Murray; Alfarra, Rami; Bacak, Asan; Pericval, Carl

    2016-04-01

    Lithium ion attachment mass spectrometry provides a non-specific, non-fragmenting and sensitive method for detection of volatile species in the gas phase. The design, manufacture, and results from lithium ion attachment ionisation sources for two mass spectrometry systems are presented. Trace gas analysis is investigated using a modified Chemical Ionization Mass Spectrometer (CIMS) and vapour pressure (VP) measurements using a modified Knudsen Effusion Mass Spectrometer (KEMS) are presented. The Li+ modified CIMS provided limits of detection of 4 ppt for acetone, 0.2 ppt for formic acid, 15 ppt for nitric acid and 120 ppt from ammonia. Despite improvements, the problem of burnout remained persistent. The Li+ CIMS would unlikely be suitable for field or aircraft work, but could be appropriate for certain lab applications. The KEMS currently utilizes an electron impact (EI) ionisation source which provides a highly sensitive source, with the drawback of fragmentation of ionized molecules (Booth et al., 2009). Using Li+ KEMS the VP of samples can be measured without fragmentation and can therefore be used to identify VPs of individual components in mixtures. The validity of using Li+ for determining the VP of mixtures was tested by making single component VP measurements, which showed good agreement with EI measurements of Poly ethylene glycol (PEG) 3 and PEG 4, both when individually measured and when mixed. The Li+ KEMS was then used to investigate a system of atmospheric relevance, α-pinene secondary organic aerosol, generated in a reaction chamber (Alfarra et al., 2012). The VPs of the individual components from this generated sample are within the range we expect for compounds capable of partitioning between the particle and gas phase of an aerosol (0.1-10-5 Pa). Li+ source has a calculated sensitivity approximately 75 times less than that of EI, but the lack of fragmentation using the Li+ source is a significant advantage.

  16. CIMS: A Context-Based Intelligent Multimedia System for Ubiquitous Cloud Computing

    Directory of Open Access Journals (Sweden)

    Abhilash Sreeramaneni

    2015-06-01

    Full Text Available Mobile users spend a tremendous amount of time surfing multimedia contents over the Internet to pursue their interests. A resource-constrained smart device demands more intensive computing tasks and lessens the battery life. To address the resource limitations (i.e., memory, lower maintenance cost, easier access, computing tasks in mobile devices, mobile cloud computing is needed. Several approaches have been proposed to confront the challenges of mobile cloud computing, but difficulties still remain. However, in the coming years, context collecting, processing, and interchanging the results on a heavy network will cause vast computations and reduce the battery life in mobiles. In this paper, we propose a “context-based intelligent multimedia system” (CIMS for ubiquitous cloud computing. The main goal of this research is to lessen the computing percentage, storage complexities, and battery life for mobile users by using pervasive cloud computing. Moreover, to reduce the computing and storage concerns in mobiles, the cloud server collects several groups of user profiles with similarities by executing K-means clustering on users’ data (context and multimedia contents. The distribution process conveys real-time notifications to smartphone users, according to what is stated in his/her profile. We considered a mobile cloud offloading system, which decides the offloading actions to/from cloud servers. Context-aware decision-making (CAD customizes the mobile device performance with different specifications such as short response time and lesser energy consumption. The analysis says that our CIMS takes advantage of cost-effective features to produce high-quality information for mobile (or smart device users in real time. Moreover, our CIMS lessens the computation and storage complexities for mobile users, as well as cloud servers. Simulation analysis suggests that our approach is more efficient than existing domains.

  17. Study on Model for Assessmentof Quality Management Performance of Coal Preparation Plant in CIMS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In this paper the method to calculate intangible quality cost is put forward for the first time based on theproduction and management characteristics of coal preparation plant. A model for assessment of quality manage-ment performance of coal preparation plant is established on the ground of quality cost. By using of CIMS integra-tion environment the strategy to carry out the model and the application example are also offered. It provides a newand feasible way to assess performance quality management of coal preparation plant.

  18. A Description Method of IEC 61850 SCL ScheMa File Based on CIM/E%一种基于CIM/E的IEC 61850 SCL ScheMa文件描述方法

    Institute of Scientific and Technical Information of China (English)

    刁东宇; 翟明玉; 王海峰; 梅德冬

    2016-01-01

    This paper introduces a description method of IEC 61850 SCL Schema file based on CIM/E lan-guage. Class template definition function of CIM/E language is used in this method to define description format of the entity classes and analyze the UML class diagram in the four major parts of the information defined in the SCL language, including communication, substation, IED and data type template. In accordance with the principles of property inheritance and implementation simplification, the method redefines the class descrip-tion format by defining description format of entity classes and generates the IEC 61850 SCL schema file based on CIM/E language for the sake of model unification in substation and dispatching point.%提供了一种基于CIM/E语言的IEC 61850 SCL Schema文件描述方法,该方法采用CIM/E语言的类模板定义功能,自定义实体类描述格式,对SCL语言中主要定义的4部分信息,包括通信类、一次设备类、智能电子设备类、数据类型模板类的UML类图进行类图分析,按照属性继承和简化实现的原则,采用自定义实体类描述格式对其进行再描述,生成基于CIM/E语言描述的IEC 61850 SCL Schema文件,以解决变电站和调度端模型不统一的问题。

  19. Profile and client satisfaction among clients of Integrated Counselling and Testing Centre for human immunodeficiency virus in Delhi

    Directory of Open Access Journals (Sweden)

    Vinoth Gnana Chellaiyan

    2014-10-01

    Full Text Available Background: Integrated Counseling and Testing Centre (ICTC is a place where a person is counseled and tested for human immunodeficiency virus (HIV and also a key entry point to the prevention of HIV infection and treatment of HIV infected people. The ICTC services are cost-effective and noncoercive intervention in the prevention of HIV/AIDS. The satisfaction of the clients availing these services indicates the quality of the services provided. Objective: The objective was to study the profile and satisfaction of clients attending counseling services of integrated counseling and testing centers in Delhi. Materials and Methods: The study was a descriptive, cross-sectional, health facility based study. The study was done in 20 ICTCs of Delhi. The ICTCs were chosen on the basis of population proportion to size. Consecutive sampling method was followed for recruiting the clients. After obtaining written consent, exit interview of 300 clients was undertaken. Results: Among 300 clients, 204 (68% were males, and 96 (32% were females. Majority, 267 (89% of the clients were staying with family and 33 (11% were staying with friends/roommates. The total number of referred clients was 270 (90% and self-referred or direct walk-in client was 30 (10%. Among the direct walk-in/self-referred clients, 12 (40% clients were recommended by their friends to come, 4 (13.3% clients seek to avail ICTC services because of high risk behavior and 14 (46.7% clients wanted to get tested for HIV as their spouse was HIV positive. About 96.3% of the clients who attended the counseling services were found to be satisfied. Conclusion: The proportion of self-referred/direct walk-in clients was very low, and low level of awareness about the HIV test and counseling services was found among the clients. This reflects the need to enhance the efforts directed at increasing the awareness of HIV test and counseling services. The satisfaction of clients could be further improved by better

  20. Chemical ionization mass spectrometry (CIMS may not measure all gas-phase sulfuric acid if base molecules are present

    Directory of Open Access Journals (Sweden)

    T. Kurtén

    2010-12-01

    Full Text Available The state-of-the art method for measuring atmospheric gas-phase sulfuric acid is chemical ionization mass spectrometry (CIMS based on nitrate reagent ions. Using computed proton affinities and reaction thermodynamics for the relevant charging reactions, we show that in the presence of strong bases such as amines, which tend to cluster with the sulfuric acid molecules, a significant fraction of the total gas-phase sulfuric acid may not be measured by a CIMS instrument. If this is the case, this effect has to be taken into account in the interpretation of atmospheric sulfuric acid measurement data, as well as in intercomparison of different CIMS instruments, which likely have different susceptibilities to amine-sulfuric acid clustering.

  1. Comparison of CIM discs and CPG glass as solid supports for bioanalytical columns used in allergen detection.

    Science.gov (United States)

    Cevdek, Ana; Franko, Mladen

    2010-09-01

    This work presents a comparison of convective interaction media (CIM) and controlled pore glass (CPG) as solid supports for immunoglobulin antibodies used in bioanalytical detection of allergens in foodstuffs. A flow-injection manifold with highly sensitive thermal lens spectrometric detection was used for this purpose. Using beta-lactoglobulin, a milk allergen, as a model analyte, CIM disc supports had a higher linear range (0.2-3.5 microg L(-1)), better reproducibility (intra-day RSD = 1%, inter-day RSD = 10%), lower consumption of reagents, and better immunocolumn stability (1 month, over 240 injections of substrate), while providing comparable LODs (0.1 microg L(-1)). Application of CIM discs as solid supports in immunocolumns for allergen detection enables fast and sensitive screening of allergens in foodstuffs with sample throughput of up to eight samples per hour.

  2. Non-invasive diagnosis of H pylori infection: Evaluation of serological tests with and without current infection marker CIM

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    AIM: To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of Hpylori infection in adult dyspeptic patients. METHODS: Consecutive non-treated dyspeptic patients undergoing diagnostic endoscopy were tested for H pylori infection by culture, rapid urease test, and histology of gastric biopsy specimens. Serum from 61 H pylori infected and 21 non-infected patients were tested for anti-H pylori IgG antibodies by commercial ELISA (Accu Bind TM ELISA, Monobind, USA), ICT(Assure(R) H pylori Rapid Test, Genelabs Diagnostics, Singapore),and immunoblot (Helico Blot 2.1,Genelabs Diagnostics, Singapore) assays. ICT and immunoblot kits cover CIN among other parameters and their performance with and without CIM was evaluated separately. RESULTS: Sensitivity, specificity, positive predictive value (PPV),negative predictive value (NPV),and accuracy of ELISA were 96.7%,42.8%,83.1%,81.8%,and 82.9%,of ICT were 90.1%,80.9%,93.2%,73.9%,and 87.8%,of ICE with CIM were 88.5%,90.4%,96.4%,73.0%,and 89.0%,of immunoblot were 98.3%,80.9%,93.7%,94.4%,and 93.9%,and of immunoblot with CIM were 98.3%,90.4%,96.7%,95.0%,and 96.3%,respectively.CONCLUSION:Immunoblot with CIM had the best performance. ICE with CIM was found to be more specific and accurate than the conventional ELISA and may be useful for non-invasive diagnosis of H pylori infection.

  3. Acquiring competence for shoot development in Arabidopsis: ARR2 directly targets A-type ARR genes that are differentially activated by CIM preincubation.

    Science.gov (United States)

    Che, Ping; Lall, Sonia; Howell, Stephen H

    2008-02-01

    Shoots can be regenerated from roots in Arabidopsis by treating root explants with cytokinin, however, shoot regeneration requires preincubation on callus induction medium (CIM) prior to induction on cytokinin-rich shoot induction medium (SIM). A cytokinin-inducible marker gene, RESPONSE REGULATOR 15 (ARR15), was identified through a "CIM dropout experiment" with similar requirements for CIM preincubation. The requirements for ARR15 contrasted to ARR5, another cytokinin-inducible ARR gene that does not require CIM preincubation. We show here that despite their differences, both ARR5 and ARR15 are direct targets of the transcriptional B-type response regulator, ARR2. This was demonstrated by identifying genes upregulated following beta estradiol induced nuclear relocation of an ARR2-estradiol receptor fusion protein. The differences in CIM preincubation requirements for ARR5 and ARR15 expression indicate an additional layer of control for these A-type ARR genes during SIM incubation. For ARR15, the CIM requirement is a transcriptional effect, because the expression of ARR15 promoter:GUS reporter gene constructs is also affected by CIM preincubation. A testable model is that transcription of ARR15, but not ARR5, is blocked by a repressor and that the effects of the repressor are relieved by CIM preincubation.

  4. Detection of processed genetically modified food using CIM monolithic columns for DNA isolation.

    Science.gov (United States)

    Jerman, Sergej; Podgornik, Ales; Cankar, Katarina; Cadet, Neza; Skrt, Mihaela; Zel, Jana; Raspor, Peter

    2005-02-11

    The availability of sufficient quantities of DNA of adequate quality is crucial in polymerase chain reaction (PCR)-based methods for genetically modified food detection. In this work, the suitability of anion-exchange CIM (Convective Interaction Media; BIA Separations, Ljubljana, Slovenia) monolithic columns for isolation of DNA from food was studied. Maize and its derivates corn meal and thermally pretreated corn meal were chosen as model food. Two commercially available CIM disk columns were tested: DEAE (diethylaminoethyl) and QA (quaternary amine). Preliminary separations were performed with standard solution of salmon DNA at different pH values and different NaCl concentrations in mobile phase. DEAE groups and pH 8 were chosen for further isolations of DNA from a complex matrix-food extract. The quality and quantity of isolated DNA were tested on agarose gel electrophoresis, with UV-scanning spectrophotometry, and by amplification with real-time PCR. DNA isolated in this way was of suitable quality for further PCR analyses. The described method is also applicable for DNA isolation from processed foods with decreased DNA content. Furthermore, it is more effective and less time-consuming in comparison with the existing proposed methods for isolation of DNA from plant-derived foods.

  5. Convergent ethical issues in HIV/AIDS, tuberculosis and malaria vaccine trials in Africa: Report from the WHO/UNAIDS African AIDS Vaccine Programme's Ethics, Law and Human Rights Collaborating Centre consultation, 10-11 February 2009, Durban, South Africa

    National Research Council Canada - National Science Library

    Mamotte, Nicole; Wassenaar, Douglas; Koen, Jennifer; Essack, Zaynab

    2010-01-01

    .... In order to explore convergent ethical issues in HIV/AIDS, TB and malaria vaccine trials in Africa, the Ethics, Law and Human Rights Collaborating Centre of the WHO/UNAIDS African AIDS Vaccine...

  6. 9 August 2011 - United Nations High Commissioner for Human Rights N. Pillay signing the guest book with Head of International Relations F. Pauss; in the ATLAS visitor centre with Collaboration Former Spokesperson P. Jenni.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    9 August 2011 - United Nations High Commissioner for Human Rights N. Pillay signing the guest book with Head of International Relations F. Pauss; in the ATLAS visitor centre with Collaboration Former Spokesperson P. Jenni.

  7. Comprehensive Instructional Management System (CIMS) Mathematics Project 1985-1986 End of Year Report. OEA Evaluation Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn. Office of Educational Assessment.

    This report describes the Comprehensive Instructional Management System (CIMS), which includes a teacher-developed mathematics curriculum for kindergarten through grade seven, corresponding criterion-referenced tests, and a computerized test scoring and reporting management system. The evaluation focused on the five pilot districts in New York…

  8. Comprehensive Instructional Managmenent Systems-Communication Arts (CIMS-CA), 1988-89. Evaluation Section Report. OREA REport.

    Science.gov (United States)

    Guerrero, Frank; And Others

    This report presents the results of the evaluation of the 1988-89 Comprehensive Instructional Management Systems-Communication Arts (CIMS-CA) program, which focused on developing a holistic communication arts curriculum and staff development program reflecting the most recent research for students in kindergarten through eighth grade;…

  9. Alignment of CIM and CAM Content Standards and Benchmarks with the PASS Proficiency Standards, Content Area: English.

    Science.gov (United States)

    Oregon State Dept. of Education, Salem.

    This paper presents the alignment of Oregon's content standards with the Certificates of Initial Mastery (CIM), Certificates of Advanced Mastery (CAM), and the Proficiency-based Admissions Standards System (PASS). After some background, a timeline, and definitions of 4 terms used in the paper, it presents charts that align common curriculum goals…

  10. 影响SDAAC-CIMS工程实施的几个关键问题的研究%Research on Critical Issues Affecting SDAAC-CIMS Implementation

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Computer integrated manufacturing system ( CIMS ) has received much attention in many industrialized countries. Shang hai Delphi Automobile Air Condition System Co., Ltd. (SDAAC), which is one of the large-scale key joint-venture enterprises engaged in developing, designing and manufacturing automobile air condition system in China, was selected for implementing 863/CIMS in 1998. The experience and lessons of the developing and implementing CIMS in the last 10 years have told us that SDAAC-CIMS is not meraly a technology exercise but an “organization revolution”. There are often much difficulties in implementing SDAAC-CIMS simply on the traditional business system. So the contents of the SDAAC-CIMS implementation is not only technical integration but also integration of people/organization, business processes and technologies. Therefore, several critical issues that must be carefully considered to ensure successful implementation of SDAAC-CIMS include commitment of the top management, reengineering of the existing processes in order to construct dynamic stable structures for aligning the SDAAC to the chaotic environment, and integration platform of information for coping with continuously changing circumstance.

  11. CIM-EARTH: Community integrated model of economic and resource trajectories for humankind.

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, J.; Foster, I.; Judd, K.; Moyer, E.; Munson, T.; Univ. of Chicago; Hoover Inst.

    2010-01-01

    Climate change is a global problem with local climatic and economic impacts. Mitigation policies can be applied on large geographic scales, such as a carbon cap-and-trade program for the entire U.S., on medium geographic scales, such as the NOx program for the northeastern U.S., or on smaller scales, such as statewide renewable portfolio standards and local gasoline taxes. To enable study of the environmental benefits, transition costs, capitalization effects, and other consequences of mitigation policies, we are developing dynamic general equilibrium models capable of incorporating important climate impacts. This report describes the economic framework we have developed and the current Community Integrated Model of Economic and Resource Trajectories for Humankind (CIM-EARTH) instance.

  12. On Ground Surface Extraction Using Full-Waveform Airborne Laser Scanner for Cim

    Science.gov (United States)

    Nakano, K.; Chikatsu, H.

    2015-05-01

    Satellite positioning systems such as GPS and GLONASS have created significant changes not only in terms of spatial information but also in the construction industry. It is possible to execute a suitable construction plan by using a computerized intelligent construction. Therefore, an accurate estimate of the amount of earthwork is important for operating heavy equipment, and measurement of ground surface with high accuracy is required. A full-waveform airborne laser scanner is expected to be capable of improving the accuracy of ground surface extraction for forested areas, in contrast to discrete airborne laser scanners, as technological innovation. For forested areas, fundamental studies for construction information management (CIM) were conducted to extract ground surface using full-waveform airborne laser scanners based on waveform information.

  13. ON GROUND SURFACE EXTRACTION USING FULL-WAVEFORM AIRBORNE LASER SCANNER FOR CIM

    Directory of Open Access Journals (Sweden)

    K. Nakano

    2015-05-01

    Full Text Available Satellite positioning systems such as GPS and GLONASS have created significant changes not only in terms of spatial information but also in the construction industry. It is possible to execute a suitable construction plan by using a computerized intelligent construction. Therefore, an accurate estimate of the amount of earthwork is important for operating heavy equipment, and measurement of ground surface with high accuracy is required. A full-waveform airborne laser scanner is expected to be capable of improving the accuracy of ground surface extraction for forested areas, in contrast to discrete airborne laser scanners, as technological innovation. For forested areas, fundamental studies for construction information management (CIM were conducted to extract ground surface using full-waveform airborne laser scanners based on waveform information.

  14. INCIDENCE, ETIOLOGY AND PATTERN OF MANDIBULAR FRACTURE IN CIMS, BILASPUR, CG, INDIA

    Directory of Open Access Journals (Sweden)

    Singh

    2015-10-01

    Full Text Available The aim of this study was to determine the incidence, etiology of mandibular fractures among different age and sex group to determine the frequency of anatomical distribution of fracture site. The study was conducted in the Department of ENT in associatio n with Department of Dentistry, CIMS, and Bilaspur. We included total 100 patients particularly with mandibular fracture and associated maxillofacial injuries. These patients were treated at Chhattisgarh Institute of Medical Sciences, Bilaspur from May 201 2 to April 2015. Among these 100 patients the most common cause of mandib le fracture is Road Traffic Acc idents with parasymphysis fracture as most common site. Incident of Mandibular fracture is mainly observed in male patients with 20 – 30 years of age group

  15. Emissions during the BHP Billiton mozal aluminium smelter Fume Treatment Centre (FTC) rebuild – A human health perspective

    CSIR Research Space (South Africa)

    Wright, C

    2011-02-01

    Full Text Available some are probable human carcinogens. As a result MOZAL initiated a human health risk assessment (HHRA) study concerning this operation, in order to understand the potential health impacts on the surrounding communities, including Mahlampsene, Sikuama...

  16. Nutrition of students from dietetics profile education in the Siedlce University of Natural Sciences and Humanities compared with students from other academic centres.

    Science.gov (United States)

    Kowalcze, Katarzyna; Turyk, Zofia; Drywień, Małgorzata

    2016-01-01

    Appropriate nutrition in humans is one of the most important factors affecting normal development, nutritional status and keeping healthy. University students can be overburdened with responsibilities arising from their studies which may result in abnormal diet/nutrition and decrease their levels of physical activity. To determine and assess nutrition and eating habits for selected female students studying nutrition at the Siedlce University of Natural Sciences & Humanities (UPH), compared with young people from other academic centres also studying nutrition and having a similar education profile. A diagnostic survey was undertaken anonymously on 100 female student subjects using a proprietary questionnaire. Students were undergraduates at the UPH during their 2nd and 3rd year. Dietetics students considered that the practical application of proper nutrition principles is very important. Nevertheless, 44% assessed themselves to follow abnormal diets; 58% declared they ate whole grains frequently whereas 58% and 65% respectively consumed fruit and vegetables daily. Dietary irregularities were identified, particularly in how often fish was eaten, where 46% either never ate fish or did so only occasionally. Subjects preferred lean cuts of poultry meat (65%), and the most common cooking practice was frying (52%). Subjects did not follow dietary recommendations, although responses varied in the different academic centres. Despite learning from their studies about normal nutritional requirements it seems that, to large degree, students follow eating habits acquired during their childhoods in the home.

  17. Experimental study on the influence of dimethylamine on the detection of gas phase sulfuric acid using chemical ionization mass spectrometry (CIMS)

    Science.gov (United States)

    Rondo, L.; Leiminger, M.; Simon, M.; Ehrhart, S.; Williamson, C.; Praplan, A.; Kürten, A.; Kirkby, J.; Curtius, J.; Cloud Collaboration

    2013-05-01

    Based on quantum chemistry calculations it has been suggested that the quantitative detection of gas phase sulfuric acid (H2SO4) by use of Chemical Ionization Mass Spectrometry (CIMS) could be biased in the presence of gas phase amines such as dimethylamine (DMA). An experiment was set up at the CLOUD aerosol chamber to test the quantitative detection of H2SO4 by CIMS by directly comparing the measured H2SO4 with and without DMA being present in the sample air. It was found that the H2SO4 cluster distribution changes but the CIMS detection efficiency is not strongly influenced.

  18. The Centre for Early Human Behaviour (EHB) at the University of Bergen: A transdisciplinary exploration into the evolution of homo sapiens behaviour

    Science.gov (United States)

    Sobolowski, Stefan; Henshilwood, Christopher; Jansen, Eystein

    2017-04-01

    Homo sapiens was anatomically modern by 200 000 years ago in Africa, but there is no archaeological evidence to demonstrate that behaviour was modern at the time. Attributes of modern behaviour, perhaps inspired by changes in the human brain, are only recognizable after 100 000 years ago. Before we can study the process, we must critically define the criteria for the term 'modern behaviour' and then find a means to recognize such behavior in the record. This seemingly simple research statement involves complex exploration by a team of specialists. In this highly competitive research field our centre will, for the first time, be able to rise to the challenge by combining the skills of cutting-edge scientists in archaeology, climate reconstruction and modelling, and the cognitive and social sciences. Over the next decade we will integrate knowledge and methods from different disciplines to synthesize approaches and contribute to a sophisticated understanding of early human behaviour. Our highly ambitious research program will focus explicitly on rare, well preserved archaeological sites occupied in the period between 100-50 000 years ago because these contain the 'keys' for unlocking the past. A major competitive edge is the EHB Director's 25 years of archaeological experience and his long-term exclusive access, with permits, to a number of the best-preserved sites in the southern Cape, South Africa - a region regarded as a major locus for vital evidence that could inform on the behaviour of early humans. Our planned excavations at existing and new sites and our ground-breaking and innovative interdisciplinary approaches, including climate (The Bjerknes Centre for Climate Research) and cognitive research, to understanding the processes that shaped human cultures. Primarily, EHB will directly address unanswered, first order questions about Homo sapiens: a) what defines the switch to 'modern behaviour', exactly how should this term be defined and then, when, why and

  19. Dive Activities from Cruise Information Management System (CIMS) for Estuary to the Abyss 2004: Exploring Along the Latitude 31-30 Transect - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  20. Dive Activities from Cruise Information Management System (CIMS) for Life on the Edge 2003: Exploring Deep Ocean Habitats - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  1. TerraSAR-X time-series interferometry detects human-induce subsidence in the Historical Centre of Hanoi, Vietnam

    Science.gov (United States)

    Le, Tuan; Chang, Chung-Pai; Nguyen, Xuan

    2016-04-01

    Hanoi was the capital of 12 Vietnamese dynasties, where the most historical relics, archaeological ruins and ancient monuments are located over Vietnam. However, those heritage assets are threatened by the land subsidence process occurred in recent decades, which mainly triggered by massive groundwater exploitation and construction activities. In this work, we use a set of high resolution TerraSAR-X images to map small-scale land subsidence patterns in the Historical Centre of Hanoi from April 2012 to November 2013. Images oversampling is integrated into the Small Baseline InSAR processing chain in order to enlarge the monitoring coverage by increasing the point-wise measurements, maintaining the monitoring scale of single building and monument. We analyzed over 2.4 million radar targets on 13.9 km2 area of interest based on 2 main sites: The Citadel, the Old Quarter and French Quarter. The highest subsidence rate recorded is -14.2 mm/year. Most of the heritage assets are considered as stable except the Roman Catholic Archdiocese and the Ceramic Mosaic Mural with the subsidence rates are -14.2 and -13.7 mm/year, respectively. Eventually, optical image and soil properties map are used to determine the causes of subsidence patterns. The result shows the strong relationships between the existing construction sites, the component of sediments and land subsidence processes that occurred in the study site.

  2. Secondary organic material formed by methylglyoxal in aqueous aerosol mimics – Part 2: Product identification using Aerosol-CIMS

    Directory of Open Access Journals (Sweden)

    V. F. McNeill

    2009-07-01

    Full Text Available We used chemical ionization mass spectrometry with a volatilization flow tube inlet (Aerosol-CIMS to characterize secondary organic material formed by methylglyoxal with ammonium sulfate in aqueous aerosol mimics. Bulk reaction mixtures were diluted and atomized to form submicron aerosol particles. Organics were detected using Aerosol-CIMS in positive and negative ion mode using I− and H3O+·(H2On as reagent ions. The results are consistent with aldol condensation products, carbon-nitrogen species, sulfur-containing compounds, and oligomeric species up to 759 amu. These results support previous observations by us and others that ammonium sulfate plays a critical role in the SOA formation chemistry of dicarbonyl compounds.

  3. Ergonomics Perspective in Agricultural Research: A User-Centred Approach Using CAD and Digital Human Modeling (DHM) Technologies

    Science.gov (United States)

    Patel, Thaneswer; Sanjog, J.; Karmakar, Sougata

    2016-06-01

    Computer-aided Design (CAD) and Digital Human Modeling (DHM) (specialized CAD software for virtual human representation) technologies endow unique opportunities to incorporate human factors pro-actively in design development. Challenges of enhancing agricultural productivity through improvement of agricultural tools/machineries and better human-machine compatibility can be ensured by adoption of these modern technologies. Objectives of present work are to provide the detailed scenario of CAD and DHM applications in agricultural sector; and finding out means for wide adoption of these technologies for design and development of cost-effective, user-friendly, efficient and safe agricultural tools/equipment and operator's workplace. Extensive literature review has been conducted for systematic segregation and representation of available information towards drawing inferences. Although applications of various CAD software have momentum in agricultural research particularly for design and manufacturing of agricultural equipment/machinery, use of DHM is still at its infancy in this sector. Current review discusses about reasons of less adoption of these technologies in agricultural sector and steps to be taken for their wide adoption. It also suggests possible future research directions to come up with better ergonomic design strategies for improvement of agricultural equipment/machines and workstations through application of CAD and DHM.

  4. Ergonomics Perspective in Agricultural Research: A User-Centred Approach Using CAD and Digital Human Modeling (DHM) Technologies

    Science.gov (United States)

    Patel, Thaneswer; Sanjog, J.; Karmakar, Sougata

    2016-09-01

    Computer-aided Design (CAD) and Digital Human Modeling (DHM) (specialized CAD software for virtual human representation) technologies endow unique opportunities to incorporate human factors pro-actively in design development. Challenges of enhancing agricultural productivity through improvement of agricultural tools/machineries and better human-machine compatibility can be ensured by adoption of these modern technologies. Objectives of present work are to provide the detailed scenario of CAD and DHM applications in agricultural sector; and finding out means for wide adoption of these technologies for design and development of cost-effective, user-friendly, efficient and safe agricultural tools/equipment and operator's workplace. Extensive literature review has been conducted for systematic segregation and representation of available information towards drawing inferences. Although applications of various CAD software have momentum in agricultural research particularly for design and manufacturing of agricultural equipment/machinery, use of DHM is still at its infancy in this sector. Current review discusses about reasons of less adoption of these technologies in agricultural sector and steps to be taken for their wide adoption. It also suggests possible future research directions to come up with better ergonomic design strategies for improvement of agricultural equipment/machines and workstations through application of CAD and DHM.

  5. Apoptosis in human germinal centre B cells by means of CC chemokine receptor 3 expression induced by interleukin-2 and interleukin-4

    Institute of Scientific and Technical Information of China (English)

    ZHANG Qiu-ping; XIE Luo-kun; ZHANG Li-jun; TAN Jin-quan

    2005-01-01

    Background CC chemokine receptor 3 (CCR3), expressed on some inflammatory cells, is a member of the chemokine receptor family. Its ligand is eotaxin/CCL11. In this research, we studied the expression and function of CCR3 induced by interleukin-2 (IL-2) and interleukin-4 (IL-4) on human germinal centre (GC) B cells.Methods Cells isolated from human tonsils were stimulated with IL-2 or/and IL-4 followed by bonding with eotaxin/CCL11. Flow cytometry was used to detect expression of CCR3 on GC B cells and apoptosis of GC B cells. Real time quantitative reverse transcription polymerase chain reaction and Northern blot assays were used to analyse the CCR3 mRNA expressed in the GC B cells. Chemotaxis and adhesion assays were used to determine the effect of eotaxin/CCL11 ligand bonded to CCR3 on GC B cells.Results There was no CCR3 expression on human freshly isolated GC B cells. The combination IL-2 and IL-4 could upregulate CCR3 mRNA and protein expression on GC B cells. Eotaxin could not induce GC B cell chemotaxis and adhesion but triggered apoptosis of GC B cells.Conclusion IL-2 and IL-4 together induced expression of CCR3 on GC B cells, and the receptor acted as a death receptor.

  6. Atmospheric SO{sub 2}. Global measurements using aircraft-based CIMS

    Energy Technology Data Exchange (ETDEWEB)

    Fiedler, V.

    2008-06-27

    Aircraft based measurements of tropospheric sulfur dioxide, SO{sub 2}, have been carried out during four campaigns in South America (TROCCINOX), Australia (SCOUT-O3), Europe (INTEX/MEGAPLUME) and Africa (AMMA). SO{sub 2} has been measured by chemical ionization mass spectrometry (CIMS), permanently online calibrated with isotopically labelled SO{sub 2}. The measurement method is described thoroughly in this work and the measured data are presented. Moreover, the data of the different regions are compared in general and typical air mass situations with SO{sub 2} enhancement are shown. A detailed analysis of four SO{sub 2} pollution plume cases emphasizes the main features: long-range transport, SO{sub 2} from metal smelters/volcanoes or from biomass burning. The SO{sub 2} measurements are analyzed in the light of simultaneously measured trace gas, particle and meteorological data. Air mass trajectory models (FLEXPART or HYSPLIT) are employed for a determination of the pollution origin. Further going evaluations with the aerosol model AEROFOR complete the analyses and point out, that the measured SO{sub 2} mole fractions are sufficient to explain new particle formation and growth. Finally, a first comparison of the measured SO{sub 2} to results from a global circulation model (ECHAM) with implemented sulfur chemistry showed a significant underestimation of the measured SO{sub 2} mole fraction by the model in the free troposphere. (orig.)

  7. Cl2 Measurements in Polluted Coastal Air Using a Br- Addition CIMS Technique

    Science.gov (United States)

    Lawler, M. J.; Saltzman, E. S.

    2008-12-01

    Molecular chlorine (Cl2) was measured in ambient air using chemical ionization mass spectrometry (CIMS) with Br- as a reagent ion. Ionization was carried out by adding CHBr3 to ambient air and flowing the gas mixture through a 63Ni ion source maintained at 300 Torr. The resulting Cl2Br- adduct was collisionally dissociated in a triple quadrupole mass spectrometer and detected as Cl-. Ambient Cl2 measurements were made at Irvine, CA, from August 1-8, 2008. Air was drawn to the instrument from outside via a ~4m long laminar flow inlet. Inlet and instrument blanks were assessed by passing ambient air through carbonate-coated glass wool, and the instrument was calibrated with a Cl2 permeation tube. During this study, the mean detection limit for Cl2 was estimated at approximately 2 ppt. Cl2 showed a diel cycle on the days it was detectable, with nighttime mixing ratios up to about 15 ppt and daytime values of a few ppt or less. A rapid decrease in Cl2 in surface air was observed overnight in association with stagnation of the nocturnal surface layer.

  8. Control in the middle (CIM) for three-period crossover studies.

    Science.gov (United States)

    Shuster, Jonathan; Anton, Stephen D; Theriaque, Douglas; Yoon, Saunjoo

    2011-09-01

    Three-period crossover studies can be efficient and convenient methods of conducting Phase II clinical trials. Non-randomly placing control in the middle (CIM) has not been practiced but may be extremely useful in studies testing herbal products for which placebos are not available, or for distinguishing between behavioral and biological effects. Furthermore, this design can serve as a valuable addition to classical studies of either (a) two competing treatments or (b) treatment versus placebo versus an open label "nothing" as the control. Therefore, we propose rigorous designs that will help practitioners efficiently answer research questions where (1) two active treatments need to be compared against each other with treatment vs. placebo comparisons being of secondary importance; (2) a single active treatment needs to be tested where no placebo is available; or (3) the placebo effect is of interest in a treatment vs. placebo trial. For studies where no placebo is available, deception will be required, with participants told that in one randomly selected period (#1 or #3) they will receive the active treatment, and that they will receive a new experimental inert placebo in the other period. Assuming this design is approved by an ethics committee, it can be very useful in biomedical research.

  9. Variation in the volatile constituents of Artemisia annua var. CIM-Arogya during plant ontogeny.

    Science.gov (United States)

    Padalia, Rajendra C; Verma, Ram S; Chauhan, Amit; Chanotiya, Chandan S; Yadav, Anju

    2011-02-01

    The essential oils yield and composition of the aerial parts of A. annua var. CIM-Arogya grown in Uttarakhand, India were analyzed and compared by capillary GC and GC-MS at different stages of development. The analysis led to the identification of 81 constituents forming 91.0%-97.1% of the essential oils compositions. The essential oil content of the aerial parts was found to vary from 0.3% to 0.7% at different stages of growth. A. annua crop harvested at full flowering and seed setting stage gave higher yield of essential oil (0.6%, 0.7%) than that harvested at pre flowering (0.5%), late vegetative (0.4%, 0.5%), mid vegetative (0.4%, 0.4%) and early vegetative stages (0.3%, 0.3%). The essential oils at different stages of growth showed monoterpenoids (38.5%-72.0%) and sesquiterpenoids (22.2%-48.2%) as major grouped constituents. The major constituents identified were camphor (22.8%-42.6%), 1,8-cineole (3.7%-8.4%), linalool (<0.1%-11.9%), beta-caryophyllene (2.0%-9.2%), (E)-beta-farnesene (1.3%-8.5%), germacrene D (0.5%-7.3%) and 1-epi-cubenol (0.7%-5.2%) in essential oil samples collected at different crop stages.

  10. Dextranase immobilization on epoxy CIM(®) disk for the production of isomaltooligosaccharides from dextran.

    Science.gov (United States)

    Bertrand, Emmanuel; Pierre, Guillaume; Delattre, Cédric; Gardarin, Christine; Bridiau, Nicolas; Maugard, Thierry; Štrancar, Aleš; Michaud, Philippe

    2014-10-13

    Endodextranase D8144 from Penicillium sp. (EC 3.2.1.2.) was immobilized on an epoxy-activated monolithic Convective Interaction Media (CIM(®)) disk in order to produce isomaltooligosaccharides (IMOS) from Dextran T40 in a continuous IMmobilized Enzymes Reactor (IMER). Enzymatic parameters and structure of IMOS were studied for free and immobilized enzymes. The immobilization efficiency of endodextranase D8144 was about 15.9% (w/w) and the real specific activity was close to 6.5 U mg enz(-1). The Km values (4.8 ± 0.2 g L(-1)) for free and immobilized enzymes were the same, showing the absence of diffusional limitation. Moreover, specific patterns of DPs (Degrees of Polymerization) distributions were observed during the enzymatic hydrolysis by HPAEC-PAD (High Pressure Anion Exchange Chromatography-Pulsed Amperometric Detection). Thus, sought-after sizes of IMOS (DPs 8-10) were generated all over the hydrolysis. Finally, the results showed the high stability of this IMER since a relative enzymatic activity about 78% was measured after 5400 volumes column.

  11. Rhizospheric Microflora Escalating Aroma Constituents and Yield Attributes in Ocimum tenuiflorum (L. cv. CIM-Ayu

    Directory of Open Access Journals (Sweden)

    Shilpi Khare Saikia

    2014-01-01

    Full Text Available The exploration of rhizospheric microbial flora for crop yield enhancement is well established. Rhizospheric microbes influence the plant physiology by imparting several beneficial effects, namely, Nitrogen fixation, increased nutrient uptake, and secondary metabolites production on their host plants. The present study investigates the response of Bacillus megaterium ATCC No. 13525, Pseudomonas fluorescens ATCC No. 14581, and Trichoderma viride MTCC No. 167 in alone and combined treatments for their effect on growth and yield parameters in a commercially important Ocimum tenuiflorum L. cv. CIM-Ayu. The plant is therapeutically important for its essential oil constituents, namely, eugenol, β-caryophyllene, and various monoterpenes. The combination treatments, T7 (B. megaterium + P. fluorescens and T8 (B. megaterium + P. fluorescens + T. viride, showed maximum enhancement (27.27% of percentage essential oil as compared to untreated control. Nutrient uptake especially N2 content was significantly increased (43% with the treatment T8 (B. megaterium + P. fluorescens + T. viride. Amongst major essential oil constituents, eugenol content was maximally increased by 58.5% as compared to 42.9% (control indicating a cumulative role of microbial inoculants for crop yield boost-up.

  12. [Acceptability of the opportunistic search for human immunodeficiency virus infection by serology in patients recruited in Primary Care Centres in Spain].

    Science.gov (United States)

    Puentes Torres, Rafael Carlos; Aguado Taberné, Cristina; Pérula de Torres, Luis Angel; Espejo Espejo, José; Castro Fernández, Cristina; Fransi Galiana, Luís

    2016-01-01

    To assess the acceptability of opportunistic search for human immunodeficiency virus (HIV). Cross-sectional, observational study. Primary Care Centres (PCC) of the Spanish National Health Care System. patients aged 18 to 65 years who had never been tested for HIV, and were having a blood test for other reasons. RECORDED VARIABLES: age, gender, stable partner, educational level, tobacco/alcohol use, reason for blood testing, acceptability of taking the HIV test, reasons for refusing to take the HIV test, and reasons for not having taken an HIV test previously. A descriptive, bivariate, multivariate (logistic regression) statistical analysis was performed. A total of 208 general practitioners (GPs) from 150 health care centres recruited 3,314 patients. Most (93.1%) of patients agreed to take the HIV test (95%CI: 92.2-93.9). Of these patients, 56.9% reported never having had an HIV test before because they considered not to be at risk of infection, whereas 34.8% reported never having been tested for HIV because their doctor had never offered it to them. Of the 6.9% who refused to take the HIV test, 73.9% considered that they were not at risk. According to the logistic regression analysis, acceptability was positively associated to age (higher among between 26 and 35 year olds, OR=1.79; 95%CI: 1.10-2.91) and non-smokers (OR=1.39; 95%CI: 1.01-1.93). Those living in towns with between 10,000 and 50,000 inhabitants showed less acceptance to the test (OR=0.57; 95%CI: 0.40-0.80). The HIV prevalence detected was 0.24% Acceptability of HIV testing is very high among patients having a blood test in primary care settings in Spain. Opportunistic search is cost-effective. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  13. Parallel enzyme-linked immunosorbent assay screening for human immunodeficiency virus among blood donors in five Chinese blood centres: a retrospective analysis.

    Science.gov (United States)

    Zeng, P; Liu, J; Wang, J; Dong, X; Li, J; Bi, X; Ma, H; Wen, X; He, M; Liu, Y; Ness, P; Shan, H

    2015-08-01

    To evaluate the strategy of parallel screening with different enzyme-linked immunosorbent assays (ELISA) among Chinese blood donors. Parallel screening with ELISA has been the main strategy to detect human immunodeficiency virus (HIV) in blood donations in China for more than a decade. The performance of the strategy should be analysed. A total of 821,927 donations collected from five Chinese blood centres in 2008-2010 were tested using two third-generation ELISAs by different manufacturers licenced and confirmed by the Western blot (WB) in this study. The confirmatory positive predictive values (PPV), false positive rates (FPR), false negative rates (FNR) and potential risks for transfusion resulting from single or sequential ELISA screening were evaluated. A total of 5318 (0·647%) of donations screened HIV reactive and were discarded. WB confirmatory results on 1668 available samples suggested that PPVs for dual ELISA, one round ELISA reactive and grey zone samples were 75·1, 0·7 and 0·5%, respectively. Eight out of 1124 one round ELISA reactive and 1 out of 195 grey zone samples were WB confirmed positive. All but one ELISA assay displayed comparable PPVs but variable FPRs and FNRs that differed by blood centre. In the absence of nucleic acid testing (NAT), parallel ELISA screening prevented a substantial number of HIV infected donations from entering the Chinese blood supply. However, the loss of false positive donors should be re-evaluated especially given the frequently reported blood supply shortage in China. © 2015 British Blood Transfusion Society.

  14. Trypanosomes of non-human primates from the National Centre of Primates, Ananindeua, State of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Ziccardi Mariangela

    2000-01-01

    Full Text Available Trypanosome infections were sought in 46 non-human primates captured principally in Amazonian Brazil. Twenty-two (47.8% were infected with four Trypanosoma species: T. cruzi, T. minasense, T. devei and T. rangeli. These preliminary results confirmed the high prevalence and diversity of natural infections with trypanosomes in primates from Brazilian Amazon and were the first formal record of simian infections with trypanosomes in the State of Acre. The presence of T. cruzi-like and T. rangeli-like parasites are recorded in four new hosts.

  15. First findings on the seroepidemiology of human paragonimosis at the anti-tuberculosis centre of Divo, Republic of Ivory Coast (West Africa

    Directory of Open Access Journals (Sweden)

    Aka N.A.

    2008-06-01

    Full Text Available An epidemiological study was carried out in 2004-2005 at the anti-tuberculosis centre of Divo (Ivory Coast to collect sera from patients who consulted for tuberculosis suspicion and to estimate the seroprevalence of human paragonimosis in the context of a systematic screening. No Paragonimus egg was found in the stools and/or sputa of the 167 persons investigated. In contrast, 41 sera were ascertained with antibodies against Paragonimus africanus using ELISA testing. As the optical density (OD values related to seropositive findings were found under 0.6 (the minimal OD to detect an active paragonimosis, the above antibody titres might originate from patients in chronic or in convalescent stages, or might result of cross reactions with trematodes. Concomitantly, dissection of local crabs (Callinectes marginatus demonstrated the presence of Paragonimus metacercariae in six out of 34 examined. The parasite burdens in crabs ranged from two to 35 cysts with a mean diameter of 302 μm. In Ivory Coast, the locality of Divo must be considered an at-risk zone in reason of the presence of anti-Paragonimus antibodies in several human sera and the presence of infected crabs at the local market.

  16. Human Resources and Vaccine Management at Provincial Health Office, District/City Health Office and Primary Health Centre

    Directory of Open Access Journals (Sweden)

    Andi Leny Susyanty

    2015-03-01

    (GAIN UCI 2010–2014 stated that the general problems of decline in immunization coverage and quality of service were caused by several things, one of which is the lack of quantity, quality and distribution of human resources. Methods: A cross-sectional mix-method study to investigate human resources in vaccine management had been conducted in two provinces in 2012. Primary data were collected by interviewing stakeholders thoroughly, secondary data collection and observation were also carried out. Analysis was done by scoring for data concerning education, length of employment, training experience and knowledge. Result:The number of Vaccine management officers are still lacking. While the immunization guidelines required minimal two officers for each health centers. Officers’ knowledge in primary health centers is still inadequate, especially in terms of the vaccine and Coldchain (Ice Lined Refrigerators. Officers at Provincial Health Office had been trained in vaccine management, but not all officers at District Health Office and Primary Health Centers had received training yet. Suggestion: This study suggests the addition of the quantity and quality of human resources in vaccine management, because the officers can affect the quality of the vaccines, because vaccines need a special handling to maintain the quality to provide immunity and prevent the occurrence of diseases that can be prevented by immunization (PD3I.Key words: vaccine, human resources, training, knowledge

  17. Coordination impairment between the somatic and parasympathetic nervous system divisions in the human sacral micturition centre following spinal cord injury.

    Science.gov (United States)

    Schalow, G

    2009-01-01

    The detrusor-sphincteric dyssynergia is analyzed by comparing the natural impulse patterns of secondary muscle spindle afferents (SP2) contributing to continence (SP2 fibre activity changes are similar to detrusor pressure changes) and sphincteric motoneurons in a brain-dead human with those in patients with spinal cord injuries. In the brain-dead the sphincteric motoneurons, subserving continence, were inhibited at a time, when preganglionic parasympathetic efferents and a SP2 fibre increased their activity (physiologic). In paraplegics the sphincteric motoneurons were not inhibited (pathophysiologic). In the brain-dead, an SP2 fibre showed doublet firing (interspike interval (II) 10 to 14 ms) for low level parasympathetic activation and multi-ending regular firing for high parasympathetic activation. In one paraplegic with strong bladder dysfunction, the multi-ending regular firing was replaced by a repeated burst firing with a shortest II of 0.2 ms (transmission frequency = 5000 Hz). The pathologic firing patterns of the SP2 fibres, the detrusor-sphincteric dyscoordination, and hyperreflexia in paraplegics are most likely a result of neuronal network changes in the parasympathetic and somatic nervous system divisions of the sacral micturition center after spinal cord injury. It is discussed that urinary bladder functions can be re-learned.

  18. Upscaling the recruitment and retention of human resources for health at primary healthcare centres in Lebanon: a qualitative study.

    Science.gov (United States)

    Alameddine, Mohamad; Khodr, Hiba; Mourad, Yara; Yassoub, Rami; Abi Ramia, Jinane

    2016-05-01

    The sustainability of primary healthcare (PHC) worldwide has been challenged by a global shortage in human resources for health (HRH). This study is a unique attempt at systematically soliciting and synthesising the voice of PHC and community stakeholders on the HRH recruitment and retention strategies at the PHC sector in Lebanon, the obstacles and challenges hindering their optimisation and the recommendations to overcome such obstacles. A qualitative design was utilised, involving 22 semi-structured interviews with PHC experts in Lebanon conducted in 2013. Nvivo qualitative data analysis software was employed for the thematic analysis of data collected from interviews. Five comprehensive themes emerged: understanding PHC scope, HRH recruitment issues, HRH retention challenges, rural areas' specific challenges and stakeholders' recommendations. Analysis of stakeholders' responses revealed a lack of a unified understanding of the PHC scope impacting the capacity for appropriate HRH planning. Identified impediments to recruitment included the suboptimal supply of HRH, financial constraints and poor management. Retention difficulties were attributed to poor working environments, financial constraints and lack of professional development. There was consensus that HRH challenges faced were aggravated in rural areas, jeopardising the equitable access to PHC services of quality. Equitable access was also jeopardised by the reported shortage of female HRH in a sociocultural context where many females prefer providers of the same gender. The study sets the path towards upscaling recruitment and retention policies and practices through the endorsement of a nationally acknowledged PHC definition and scope, the sustainable development of the PHC workforce and through the implementation of targeted recruitment and retention strategies addressing rural settings and gender equity. Decision-makers and planners are urged to identify HRH as the most important input for the success

  19. Atmospheric Amines and Ammonia Measured with a Chemical Ionization Mass Spectrometer (CIMS)

    Energy Technology Data Exchange (ETDEWEB)

    You, Y.; Kanawade, V. P.; de Gouw, J. A.; Guenther, Alex B.; Madronich, Sasha; Sierra-Hernandez, M. R.; Lawler, M.; Smith, James N.; Takahama, S.; Ruggeri, G.; Koss, A.; Olson, K.; Baumann, K.; Weber, R. J.; Nenes, A.; Guo, H.; Edgerton, Eric S.; Porcelli, L.; Brune, W. H.; Goldstein, Allen H.; Lee, S.-H

    2014-11-19

    We report ambient measurements of amines and ammonia with a fast response chemical ionization mass spectrometer (CIMS) in a Southeastern U.S. forest in Alabama and a moderately polluted Midwestern site during the summer. In the Alabama forest, mostly C3-amines (from pptv to tens of pptv) and ammonia (up to 2 ppbv) were detected on a daily basis. C3-amines and ammonia showed similar diurnal trends and temperature and wind direction dependences, and were not associated with transported CO and SO2 plumes. Consistent with temperature dependences, amine and ammonia in the gas and aerosol phases showed opposite diurnal trends, indicating gas-to-particle partitioning of amines and ammonia. Temperature dependences also imply reversible processes of amines and ammonia evaporation from soil surfaces in daytime and deposition of amines and ammonia to soil surfaces at nighttime. Various amines (C1-C6) at the pptv level were observed in the transported biomass burning plumes, showing that biomass burning can be a substantial source of amines in the Southeast U.S. At the moderately polluted Kent site, higher concentrations of amines (C1-C6, from pptv to tens of pptv) and ammonia (up to 6 ppbv) were detected. Diurnal variations of C1- to C3-amines and ammonia were correlated with the ambient temperature. C4- to C6-amines showed abrupt increases during the nighttime, suggesting that they were emitted from local sources. These abundant amines and ammonia may in part explain the frequent new particle formation events reported from Kent. Lower amine concentrations at the rural forested site highlight the importance of constraining anthropogenic sources of amines.

  20. Atmospheric amines and ammonia measured with a Chemical Ionization Mass Spectrometer (CIMS

    Directory of Open Access Journals (Sweden)

    Y. You

    2014-06-01

    Full Text Available We report ambient measurements of amines and ammonia with a~fast response chemical ionization mass spectrometer (CIMS in a southeastern US forest in Alabama and a~moderately polluted Midwestern site during the summer. In the Alabama forest, mostly C3-amines (from pptv to tens of pptv and ammonia (up to 2 ppbv were detected on a daily basis. C3-amines and ammonia showed similar diurnal trends and temperature and wind direction dependences, and were not associated with transported CO and SO2 plumes. Consistent with temperature dependences, amine and ammonia in the gas and aerosol phases showed opposite diurnal trends, indicating gas-to-particle partitioning of amines and ammonia. Temperature dependences also imply reversible processes of amines and ammonia evaporation from soil surfaces in daytime and deposition of amines and ammonia to soil surfaces at nighttime. Various amines (C1–C6 at the pptv level were observed in the transported biomass burning plumes, showing that biomass burning can be a substantial source of amines in the Southeast US. At the moderately polluted Kent site, higher concentrations of amines (C1–C6, from pptv to tens of pptv and ammonia (up to 6 ppbv were detected. Diurnal variations of C1- to C3-amines and ammonia were correlated with the ambient temperature. C4- to C6-amines showed abrupt increases during the nighttime, suggesting that they were emitted from local sources. These abundant amines and ammonia may in part explain the frequent new particle formation events reported from Kent. Lower amine concentrations at the rural forested site highlight the importance of constraining anthropogenic sources of amines.

  1. A STUDY OF PATTERN, SURGICAL MANAGE MENT AND OUTCOME OF BEAR MAULING AT CIMS BILASPUR

    Directory of Open Access Journals (Sweden)

    Santosh

    2015-07-01

    Full Text Available We studied the various injury patterns in bear mauling and outcome of management in CIMS from 2010 to 2014. A total of 20 cases evaluated which were predominantly male (95%. It is obvious that involvement of head, neck face and upper limb was in maximum cases. The age wise study shows that there was equal involvement of people from young, middle aged and older ones. It was a retrospective analysis of the reported cases. Most victims suffered from multiple injuries. Percentage wise distribution of the injuries and involvement of different body parts amongst observed cases were head neck face 75%, thorax and abdomen 40%, upper limb 75%, buttocks and genitals 30% , lower limb 50%. We observed that in 75% of cases of mutilation over h ead neck and face, it was most common site of bear mauling. Probably, it is because usually the attacks by bear is mainly on standing posture with hind limbs. All the patients were treated by a team led by surgeons including dental cum oral surgeon, otorhinolaryngologist, ophthalmologist and orthopedician. Surgical repair was done under all aseptic precaution and analgesia. Because of severe anatomical distortion of face and multiple fractures of facial bones with unstable and hanging mandible, in number of cases urgent tracheostomy was performed to restore the airways and for induction of general anesthesia. This also prevents aspiration and regurgitation. The excell ent blood supply of the face makes infection a rare occurrence with good antibiotic coverage. However, the injury may cause sufficient disfigurement and require extensive reconstruction. We also observed eye globe rupture in some cases and enucleation was inevitable. We conclude that multidisciplinary approach and follow up reduced the rate of infection and morbidity and mortality.

  2. Relation Implementation of CIM Logical Model%CIM逻辑模型的关系实现

    Institute of Scientific and Technical Information of China (English)

    柳文; 柳明

    2011-01-01

    Corresponding to the lack in abilities of storage and query, a relation scheme, which owns the identical representation with CIM logical model, is defined. Those constraints in logical model, which take the form of logical sentences, are transformed into constraints on the cardinal of some related logical relations. With respects to the model access, the DAF interface, which is the basic CIS interface of IEC61970, is realized by relation algebra as an example. Research results show that the efficiencies of query and availability of constraintverification can be acquired by a well choosing relation scheme, while the rich representative ability of logical model is still reserved.%针对逻辑模型在查询和存储方面的不足,定义与其具有一致表示能力的关系模型,并将逻辑模型中以句子形式表示的逻辑约束转化为针对关系模型中逻辑关系的势的约束.根据模型的访问,以IEC61970所采用的数据访问接口DAF为例,在上述关系模型中给出基于关系代数的实现.研究结果表明,通过选择合理的关系模型,可以在保持逻辑模型丰富的表达能力的基础上,利用关系代数提高模型访问的效率,同时保证约束判定的有效性.

  3. CIM和DAS多样性的定量分析%Diversity Quantitative Analysis on CIM and DAS

    Institute of Scientific and Technical Information of China (English)

    徐智; 雷晴; 陈冬雷

    2014-01-01

    基于NUREG/CR-7007量化多样性的方法,分析了AP1000标准设计中部件接口模块(CIM)和多样化驱动系统(DAS)的多样性属性,计算了归一化多样性量值.多样性灵敏度分析揭示了CIM和DAS归一化多样性量值裕量的不足,给出了应加强对系统实施监控及可行的改进建议.

  4. Design of a microprocessor-based Control, Interface and Monitoring (CIM unit for turbine engine controls research

    Science.gov (United States)

    Delaat, J. C.; Soeder, J. F.

    1983-01-01

    High speed minicomputers were used in the past to implement advanced digital control algorithms for turbine engines. These minicomputers are typically large and expensive. It is desirable for a number of reasons to use microprocessor-based systems for future controls research. They are relatively compact, inexpensive, and are representative of the hardware that would be used for actual engine-mounted controls. The Control, Interface, and Monitoring Unit (CIM) contains a microprocessor-based controls computer, necessary interface hardware and a system to monitor while it is running an engine. It is presently being used to evaluate an advanced turbofan engine control algorithm.

  5. CMS Centre at CERN

    CERN Multimedia

    2007-01-01

    A new "CMS Centre" is being established on the CERN Meyrin site by the CMS collaboration. It will be a focal point for communications, where physicists will work together on data quality monitoring, detector calibration, offline analysis of physics events, and CMS computing operations. Construction of the CMS Centre begins in the historic Proton Synchrotron (PS) control room. The historic Proton Synchrotron (PS) control room, Opened by Niels Bohr in 1960, will be reused by CMS to built its control centre. TThe LHC@FNAL Centre, in operation at Fermilab in the US, will work very closely with the CMS Centre, as well as the CERN Control Centre. (Photo Fermilab)The historic Proton Synchrotron (PS) control room is about to start a new life. Opened by Niels Bohr in 1960, the room will be reused by CMS to built its control centre. When finished, it will resemble the CERN Contro...

  6. The effect of H2SO4 - amine clustering on chemical ionization mass spectrometry (CIMS) measurements of gas-phase sulfuric acid

    DEFF Research Database (Denmark)

    Kurten, T.; Petaja, T.; Smith, J.;

    2011-01-01

    by the CIMS instrument, though the most reliable computational methods employed predict this fraction to be small; on the order of ten percent or less. Third, the amine molecules will evaporate practically immediately after charging, thus evading detection. These effects may need to be taken into account......The state-of-the art method for measuring atmospheric gas-phase sulfuric acid is chemical ionization mass spectrometry (CIMS) based on nitrate reagent ions. We have assessed the possible effect of the sulfuric acid molecules clustering with base molecules on CIMS measurements using computational...... chemistry. From the computational data, three conclusions can be drawn. First, a significant fraction of the gas-phase sulfuric acid molecules are very likely clustered with amines if the amine concentration is around or above a few ppt. Second, some fraction of these acid-amine clusters may not be charged...

  7. 计算机集成制造(CIM),工业4.0及通往语义之路%Computer Integrated Manufacturing (CIM), Industrie 4.0 and the Way to Semantics

    Institute of Scientific and Technical Information of China (English)

    因果·罗莱; 惠敦炎

    2016-01-01

    为把工业4.0付诸实施,一个有用的和切实可行的标准是一个不能放弃的元素.人们应当规划标准化的路径.但是,可以预期的是,总会遇到意外的障碍和创建崭新的态势.人们可以预测,最大的障碍可能会出现在哪些领域?本文试图就这些问题通过阐述工业4.0与起源于1980年的计算机集成制造(CIM)标准化历程的相似之处给出答案.文章指出,针对当前的标准化工作,我们应从CIM-时代中汲取哪些教训,哪些方面是可以传承下去的,必定要踏上的新大陆究竟在何方?

  8. The Carbapenem Inactivation Method (CIM), a Simple and Low-Cost Alternative for the Carba NP Test to Assess Phenotypic Carbapenemase Activity in Gram-Negative Rods

    Science.gov (United States)

    van der Zwaluw, Kim; de Haan, Angela; Pluister, Gerlinde N.; Bootsma, Hester J.; de Neeling, Albert J.; Schouls, Leo M.

    2015-01-01

    A new phenotypic test, called the Carbapenem Inactivation Method (CIM), was developed to detect carbapenemase activity in Gram-negative rods within eight hours. This method showed high concordance with results obtained by PCR to detect genes coding for the carbapenemases KPC, NDM, OXA-48, VIM, IMP and OXA-23. It allows reliable detection of carbapenemase activity encoded by various genes in species of Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae), but also in non-fermenters Pseudomonas aeruginosa and Acinetobacter baumannii. The CIM was shown to be a cost-effective and highly robust phenotypic screening method that can reliably detect carbapenemase activity. PMID:25798828

  9. The carbapenem inactivation method (CIM), a simple and low-cost alternative for the Carba NP test to assess phenotypic carbapenemase activity in gram-negative rods.

    Science.gov (United States)

    van der Zwaluw, Kim; de Haan, Angela; Pluister, Gerlinde N; Bootsma, Hester J; de Neeling, Albert J; Schouls, Leo M

    2015-01-01

    A new phenotypic test, called the Carbapenem Inactivation Method (CIM), was developed to detect carbapenemase activity in Gram-negative rods within eight hours. This method showed high concordance with results obtained by PCR to detect genes coding for the carbapenemases KPC, NDM, OXA-48, VIM, IMP and OXA-23. It allows reliable detection of carbapenemase activity encoded by various genes in species of Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae), but also in non-fermenters Pseudomonas aeruginosa and Acinetobacter baumannii. The CIM was shown to be a cost-effective and highly robust phenotypic screening method that can reliably detect carbapenemase activity.

  10. The carbapenem inactivation method (CIM, a simple and low-cost alternative for the Carba NP test to assess phenotypic carbapenemase activity in gram-negative rods.

    Directory of Open Access Journals (Sweden)

    Kim van der Zwaluw

    Full Text Available A new phenotypic test, called the Carbapenem Inactivation Method (CIM, was developed to detect carbapenemase activity in Gram-negative rods within eight hours. This method showed high concordance with results obtained by PCR to detect genes coding for the carbapenemases KPC, NDM, OXA-48, VIM, IMP and OXA-23. It allows reliable detection of carbapenemase activity encoded by various genes in species of Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae, but also in non-fermenters Pseudomonas aeruginosa and Acinetobacter baumannii. The CIM was shown to be a cost-effective and highly robust phenotypic screening method that can reliably detect carbapenemase activity.

  11. Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y.

    Science.gov (United States)

    Bilir, Ayhan; Erguven, Mine; Yazihan, Nuray; Aktas, Esin; Oktem, Gulperi; Sabanci, Akin

    2010-12-01

    The aim of this work is to investigate whether clomipramine (CIM) and lithium chloride (LiCl) potentiate the cytotoxicity of vinorelbine (VNR) on SH-SY5Y human neuroblastoma cells in vitro and whether midkine (MK) can be a resistance factor for these treatments. Four groups of experiments were performed for 96 h using both monolayer and spheroid cultures of SH-SY5Y cells: (1) control group, (2) singly applied VNR, CIM, and LiCl, (3) VNR with CIM, and (4) VNR with LiCl. Their effects on monolayer and spheroid cultures were determined by evaluating cell proliferation, bromodeoxyuridine labeling index (BrdU-LI), apoptosis, cyclic adenosine monophosphate (cAMP) and midkine levels, colony-forming efficiency, spheroid size, and ultrastructure. In comparison with the control group, single and combination drug treatments significantly reduced the proliferation index (PI) for 96 h. The most potent reduction of PI was observed with VNR in combination with CIM and LiCl for all time intervals. VNR with CIM and LiCl seemed to be ineffective in reducing BrdU-LI of both monolayer cell and spheroid cultures, spheroid size, and cAMP level. VNR with LiCl increased apoptosis at 24 h, however VNR with CIM increased apoptosis at 96 h. VNR was the most potent drug in inhibiting colony-forming efficiency. The combination of VNR with CIM was the most potent in reducing midkine levels among all groups. Interestingly, the combination of VNR with LiCl led to both nuclear membrane breakdown and disappearance of the cellular membranes inside the spheroids. Both CIM and LiCl seemed to potentiate VNR-induced cytotoxicity, and MK was not a resistance factor for VNR, LiCl, and CIM.

  12. Factors associated with "Ikigai" among members of a public temporary employment agency for seniors (Silver Human Resources Centre in Japan; gender differences

    Directory of Open Access Journals (Sweden)

    Toyoda Yasuhiro

    2006-02-01

    Full Text Available Abstract Background "Ikigai" is culturally defined in the society of Japan as a comprehensive concept describing subjective well-being. It is considered to be related to life-satisfaction, self-esteem, morale, happiness as well as evaluation towards meaning of one's life. Although previous studies examined factors associated with Ikigai with smaller samples, consistent results have not been obtained, especially from the viewpoint of gender differences. Identification of gender-specific factors related with Ikigai among the elderly, may be of value to enhance subjective well-being. Methods Self-administered questionnaires were distributed among 4,737 randomly selected members of the Silver Human Resources Centre (SHRC, a public temporary employment agency for seniors, in Osaka, Japan. This represents about 10% of all registered members (n = 41,593 in the 38 SHRC centres in Osaka. A total of 4,376 subjects (male: 2,913; female: 1,463 provided a satisfactory response to the questionnaire (response rate: 92%. The status whether they have "Ikigai" or not was evaluated by self-anchoring scale ranging from 0 to 5 (0 = lowest rate and 5 = highest rate of having "Ikigai". Also, self-rated life-change score through work (-3 to 3 was evaluated by three items, i.e. changes in (1 the number of friends through work, (2 social interests and (3 the quantity of conversation with others (1 = increase, 0 = no change, and -1 = decrease. Results The factors associated with "Ikigai" for total subjects were the number of rooms in one's residence, annual income, healthy life style score (Breslow, the number of working days through SHRC, satisfaction with one's life history and life-change sore through work. The multivariable odds ratio (95%CI of having "Ikigai" was 1.9 (1.1–3.3 for persons with no change in life thorough work compared with subjects with a score of ≦-1. Moreover, the multivariable odds ratios were 3.5 (1.9–6.6 for a life-change score = 1, 3.1 (1

  13. The Carbapenem Inactivation Method (CIM), a Simple and Low-Cost Alternative for the Carba NP Test to Assess Phenotypic Carbapenemase Activity in Gram-Negative Rods

    NARCIS (Netherlands)

    Zwaluw, K. van der; Haan, A. de; Pluister, G.N.; Bootsma, H.J.; Neeling, A.J. de; Schouls, L.M.

    2015-01-01

    A new phenotypic test, called the Carbapenem Inactivation Method (CIM), was developed to detect carbapenemase activity in Gram-negative rods within eight hours. This method showed high concordance with results obtained by PCR to detect genes coding for the carbapenemases KPC, NDM, OXA-48, VIM, IMP a

  14. The Carbapenem Inactivation Method (CIM), a Simple and Low-Cost Alternative for the Carba NP Test to Assess Phenotypic Carbapenemase Activity in Gram-Negative Rods

    NARCIS (Netherlands)

    Zwaluw, K. van der; Haan, A. de; Pluister, G.N.; Bootsma, H.J.; Neeling, A.J. de; Schouls, L.M.

    2015-01-01

    A new phenotypic test, called the Carbapenem Inactivation Method (CIM), was developed to detect carbapenemase activity in Gram-negative rods within eight hours. This method showed high concordance with results obtained by PCR to detect genes coding for the carbapenemases KPC, NDM, OXA-48, VIM, IMP a

  15. 网络数据库管理技术在CIMS工程中的应用%MANAGEMENT TECHNOLOGY OF WEB DATABASE FOR APPLICATIONS IN CIMS ENGINEERING

    Institute of Scientific and Technical Information of China (English)

    孟飙; 贺向新

    2001-01-01

    CIMS技术在制造业的应用是制造业和信息技术融合必然趋势.作为CIMS应用的支撑平台也随着Internet的迅猛发展不断完善提高,因而Web技术和企业Internet数据的集成一直是人们关注的热点.本文在研究参考了多种Web和CIMS技术之后,通过一定程度的验证,提出了适合中小企业应用的信息方案.%Accompanying by the development of IT since 20 century,all kinds of enterprise have had a great change on its management,production,and so on. It is an inevitable tendency that CIMS and IT technologies are fusing in the applications of CIMS technologies in manufacture. The supporting platform for CIMS applications are becoming flawless unceasingly following the rapidly developing of Internet,hence ,the integrated technology of Web and data from enterprises intranet is a hotspot for a long time. In this article,after researching and referencing manifold Web and CIMS technologies,with a validating in some degree,brings forward an information management project that is suitable to medium or small enterprises.

  16. A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of ERbeta in archival formalin-fixed paraffin embedded human breast tissue.

    Science.gov (United States)

    Carder, Pauline J; Murphy, Claire E; Dervan, Peter; Kennedy, Maria; McCann, Amanda; Saunders, Philippa T K; Shaaban, Abeer M; Foster, Christopher S; Witton, Caroline J; Bartlett, John M S; Walker, Rosemary A; Speirs, Valerie

    2005-08-01

    Estrogen receptor (ER) alpha is a well-established independent prognostic factor in breast cancer whose presence determines the clinical implications of adjuvant endocrine therapy. A second receptor, ERb has been described, and a number of studies have examined its expression in breast tissue. However elucidation of the role played by ERb has been hampered by published immunohistochemical studies employing a variety of protocols and scoring systems such that inter-laboratory comparisons are difficult. Here we present a multi-centre study designed to critically evaluate inter-laboratory differences in methodology. Six UK and Irish centres participated in this study. A small series of breast cancers were stained using centre-specific laboratory protocols and scored using both centrespecific and standard scoring protocols. There was generally poor agreement as to what constituted a positive or negative case when centre-specific scoring systems were used with less than half of all cases in agreement. Concordance was improved when a standard scoring system was used but varied according to threshold for positivity employed and primary antibody. Our results emphasise the need for further studies addressing the role of ERb to be based on a wider consensus on criteria for positivity. Ideally this should be based on calibration against clinical outcome.

  17. An Analysis of Context-Aware Data Models for Smart Cities: Towards Fiware and Etsi Cim Emerging Data Model

    Science.gov (United States)

    Jara, A. J.; Bocchi, Y.; Fernandez, D.; Molina, G.; Gomez, A.

    2017-09-01

    Smart Cities requires the support of context-aware and enriched semantic descriptions to support a scalable and cross-domain development of smart applications. For example, nowadays general purpose sensors such as crowd monitoring (counting people in an area), environmental information (pollution, air quality, temperature, humidity, noise) etc. can be used in multiple solutions with different objectives. For that reason, a data model that offers advanced capabilities for the description of context is required. This paper presents an overview of the available technologies for this purpose and how it is being addressed by the Open and Agile Smart Cities principles and FIWARE platform through the data models defined by the ETSI ISG Context Information Management (ETSI CIM).

  18. Assessment Of Mold-Design Dependent Textures In CIM-Components By Polarized Light Optical Texture Analysis (PLOTA)

    Science.gov (United States)

    Kern, Frank; Rauch, Johannes; Gadow, Rainer

    2007-04-01

    By thermoplastic ceramic injection moulding (CIM) ceramic components of high complexity can be produced in a large number of items at low dimensional tolerances. The cost advantage by the high degree of automation leads to an economical mass-production. The structure of injection-moulded components is determined by the form filling behaviour and viscosity of the feedstock, the machine parameters, the design of the mold and the gate design. With an adapted mold- and gate-design CIM-components without textures are possible. The "Polarized Light Optical Texture analysis" (PLOTA) makes it possible to inspect the components and detect and quantify the textures produced by a new mold. Based on the work of R. Fischer (2004) the PLOTA procedure was improved by including the possibility to measure the inclination angle and thus describe the orientation of the grains in three dimensions. Sampled thin sections of ceramic components are analysed under the polarization microscope and are brought in diagonal position. Pictures are taken with a digital camera. The pictures are converted in the L*a*b*- colour space and the crystals color values a* and b* in the picture are measured. The color values are compared with the values of a quartz wedge, which serves as universal standard. From the received values the inclination angle can be calculated relative to the microscope axis. It is possible to use the received data quantitatively e.g. for the FEM supported simulation of texture-conditioned divergences of mechanical values. Thus the injection molding parameters can be optimized to obtain improved mechanical properties.

  19. 卷烟业CIMS工程的设计与实施%Designing and Implemention of CIMS in Tobacco Industry

    Institute of Scientific and Technical Information of China (English)

    李秀; 张旭旭; 刘文煌; 乐同; 徐哲学

    2001-01-01

    Based on analyzing the present situation and the characteristics of production operations in tobacco industry, the system architecture and function module of HY-CIMS are described. Some problems and the solved methods of key technologies on design and implementation are pointed out. Based on the operation situation, the system includes design, production, sale, purvey, storage, financial affairs, spare part, quality management, personnel, labor and capital, hieroglyph file, OA, synthetical query, etc. subsystems. These subsystems can run independently, and make up of closed loop ERP. The research in the paper affords experience and gist for the spread of CIMS in tobacco industry.%分析了卷烟企业的生产经营现状及生产特点,给出了HY-CIMS应用工程的体系结构和功能模块,指出了HY-CIMS设计和实施中的几个关键技术及解决方法。该应用工程针对企业业务情况,包括设计、生产、销售、供应、库存、财务、备件、质量管理、人事劳资、图文档案、办公自动化和综合查询等子系统。既可以独立运行,又可以构成严格意义上的闭环ERP。本文的研究为CIMS工程在卷烟企业的推广提供了经验与依据。

  20. Virtual particle therapy centre

    CERN Multimedia

    2015-01-01

    Particle therapy is an advanced technique of cancer radiation therapy, using protons or other ions to target the cancerous mass. This advanced technique requires a multi-disciplinary team working in a specialised centre. 3D animation: Nymus3D

  1. The IGU Knowledge Centre

    NARCIS (Netherlands)

    Huizing, Bernardus

    2005-01-01

    This article describes an innovative service for members of the International Gas Union - IGU. The IGU Knowledge Centre provides members with relevant information and data. In this article is described why, how and where.

  2. CENTRE FOR GEOMETRICAL METROLOGY

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    The objective of this Annual Report is to give a general introduction to CGM as well as to give an account of the tasks carried out using the facilities of CGM's Instrument Centre during 1998 and 1999....

  3. Description Model of Warehouse Architecture for Clinical Test at the Molecular Immunology Centre

    Directory of Open Access Journals (Sweden)

    Anthony Rafael Sotolongo León

    2012-05-01

    Full Text Available Accurate and detailed description of the architecture of computer systems is very important to achieve success in their development. As informatic solutions, data warehouses and software support decision-making in institutions that need to implement a detailed description of the architecture. Ralph Kimball proposes the aspects to be considered of the description and explains how it is done. There are specific models used to describe the architecture such as Kruchten 4 +1 views of meta-model or the Common Warehouse Metamodel (CWM however these models do not meet the need of the description that requires a data warehouse that integrates information from clinical trials of the Molecular Immunology Centre (CIM. In this paper we propose a model for describing the data warehouse architecture that fits the needs of the Molecular Immunology Center following the Kimball framework and using as UML 2.0 modeling language.

  4. 源于业务的CIM模型实现通用方法框架%A Common Methodological Framework for Business to CIM Implementation

    Institute of Scientific and Technical Information of China (English)

    郑灶贤; 杜炎

    2014-01-01

    在电力行业,IEC61970/61968 CIM因为可以解决信息孤岛问题而成为当前电力企业进行信息交互的标准并被广泛使用。众所周知IEC CIM模型是一个比较庞大的体系,在应用中都是采取相应范围的裁剪和按照需求进行相应的扩充,我们称之为定制化。由于各个人或厂商对于CIM模型的理解不一致,在裁剪或扩充的时候难免出现诸如实用性、与前版本的一致性和可扩充性等的差异问题。特别是在实践中发现在支持接入不同时期、由不同厂商开发的正在运行的应用系统基于CIM标准的实例化有各自的方式和方法,所以电力企业将面临着不同应用系统采用不同CIM标准版本进行的实例化情况,非常难以管理。为了解决同一个CIM模型标准落地存在差异的问题,介绍一种通过实践融合了业务建模方法(BPMN 2.0)、智能电网系统的需求开发方法论(IEC62559)和IEC通用方法框架CMF的方法框架,从方法论的角度约束或指导CIM模型落地。%In the power industry, IEC61970/61968 CIM which used to solve the problem of information islands for power companies now becomes the standard for information exchange and widely used. Well-known IEC CIM model is a relatively large system, we are taking in the application corresponding scope accordance with the actual needs of the crop and the expansion, we call it customization. As each individual or vendor has different understanding of CIM model, there are many problems such as usability, consistency with the previous version and scalability issues , etc. when cutting or expansion. Especially in implementation, we find that applications developed by different vendors at different times, are running on the instantiation of CIM standards with their own ways and means, the power companies will be faced with different applications using different CIM standards examples of CIM versions, and they are very difficult to

  5. 石化企业CIMS工程关键技术研究%Research on Key technology of CIMS Engineering in Petrochemical Enterprise

    Institute of Scientific and Technical Information of China (English)

    王丽萍

    2002-01-01

    介绍了863/CIMS示范工程大庆石油化工总厂化工一厂CIMS工程(DQE-CIMS)的关键技术及解决方案.对DQE-CIMS工程的总体技术、网络技术、浏览器技术和数据库技术等进行详细论述.

  6. 基于CIM/E文件的电网全景建模技术研究%Study on Modeling Technology for Power Grid Panorama Based on CIM/E File

    Institute of Scientific and Technical Information of China (English)

    邓大为; 李可; 陆俊

    2013-01-01

    针对电网进行全景建模需求不断增长的问题,对多个电力自动化专业系统和数据集成技术展开研究,提出一种创建电网全景模型的解决方案.通过电力自动化专业系统提供的模型描述规范语言(common informationmodel,CIM/E)文件中获取子模型数据,利用数据提取、转换和加载(extraction-transformation-loading,ETL)技术将子模型数据抽取、转换并集成到统一的电网全景模型中,解决了直接访问各应用系统数据库会暴露数据库设计及对数据库性能产生影响的问题.

  7. CIMS环境下支持并行设计的PDM系统简介%Introduction to PDM System Used for Parallel Design in CIMS Environment

    Institute of Scientific and Technical Information of China (English)

    顾红; 宋鹏云

    2001-01-01

    随着全球经济一体化的发展,市场竞争日趋激烈。为确保在市场竟争中立于不败之地,实施计算机集成制造系统( CIMS)技术是其强有力的保证措施。而产品数据库管理( PDM)是实现 CIMS应用的关键技术之一。本文介绍和研究了 PDM系统原理和体系结构以及并行过程的要求,讨论了在 CIMS环境下,支持并行设计的PDM的总体技术方案。%With the development of the global economy integration, the market competition is more intense. To not be lost in the market, the execution of the computer integrated manufacture system (CIMS) is a strong competing method. The product database management (PDM) is the key technique in CIMS. In this article, the principles and system of PDM as well as the requirement of the parallel process were introduced and researched. Then, the global technique scheme of PDM that supports the parallel design in the CIMS environment was discussed.

  8. Observations of VOC emissions and photochemical products over US oil- and gas-producing regions using high-resolution H3O+ CIMS (PTR-ToF-MS

    Directory of Open Access Journals (Sweden)

    A. Koss

    2017-08-01

    Full Text Available VOCs related to oil and gas extraction operations in the United States were measured by H3O+ chemical ionization time-of-flight mass spectrometry (H3O+ ToF-CIMS/PTR-ToF-MS from aircraft during the Shale Oil and Natural Gas Nexus (SONGNEX campaign in March–April 2015. This work presents an overview of major VOC species measured in nine oil- and gas-producing regions, and a more detailed analysis of H3O+ ToF-CIMS measurements in the Permian Basin within Texas and New Mexico. Mass spectra are dominated by small photochemically produced oxygenates and compounds typically found in crude oil: aromatics, cyclic alkanes, and alkanes. Mixing ratios of aromatics were frequently as high as those measured downwind of large urban areas. In the Permian, the H3O+ ToF-CIMS measured a number of underexplored or previously unreported species, including aromatic and cycloalkane oxidation products, nitrogen heterocycles including pyrrole (C4H5N and pyrroline (C4H7N, H2S, and a diamondoid (adamantane or unusual monoterpene. We additionally assess the specificity of a number of ion masses resulting from H3O+ ion chemistry previously reported in the literature, including several new or alternate interpretations.

  9. Observations of VOC emissions and photochemical products over US oil- and gas-producing regions using high-resolution H3O+ CIMS (PTR-ToF-MS)

    Science.gov (United States)

    Koss, Abigail; Yuan, Bin; Warneke, Carsten; Gilman, Jessica B.; Lerner, Brian M.; Veres, Patrick R.; Peischl, Jeff; Eilerman, Scott; Wild, Rob; Brown, Steven S.; Thompson, Chelsea R.; Ryerson, Thomas; Hanisco, Thomas; Wolfe, Glenn M.; St. Clair, Jason M.; Thayer, Mitchell; Keutsch, Frank N.; Murphy, Shane; de Gouw, Joost

    2017-08-01

    VOCs related to oil and gas extraction operations in the United States were measured by H3O+ chemical ionization time-of-flight mass spectrometry (H3O+ ToF-CIMS/PTR-ToF-MS) from aircraft during the Shale Oil and Natural Gas Nexus (SONGNEX) campaign in March-April 2015. This work presents an overview of major VOC species measured in nine oil- and gas-producing regions, and a more detailed analysis of H3O+ ToF-CIMS measurements in the Permian Basin within Texas and New Mexico. Mass spectra are dominated by small photochemically produced oxygenates and compounds typically found in crude oil: aromatics, cyclic alkanes, and alkanes. Mixing ratios of aromatics were frequently as high as those measured downwind of large urban areas. In the Permian, the H3O+ ToF-CIMS measured a number of underexplored or previously unreported species, including aromatic and cycloalkane oxidation products, nitrogen heterocycles including pyrrole (C4H5N) and pyrroline (C4H7N), H2S, and a diamondoid (adamantane) or unusual monoterpene. We additionally assess the specificity of a number of ion masses resulting from H3O+ ion chemistry previously reported in the literature, including several new or alternate interpretations.

  10. Academic Drug Discovery Centres

    DEFF Research Database (Denmark)

    Kirkegaard, Henriette Schultz; Valentin, Finn

    2014-01-01

    Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...... their performance....

  11. CENTRE IN NIGERIA.

    African Journals Online (AJOL)

    PATTERN OF NEURO-OPHTHALMIC DISORDERS IN A TERTIARY EYE. CENTRE IN NIGERIA. A E Omoti , M J M ... movement or light was determined. The external ... assessed by color desaturation tests and visual field assessment by the ...

  12. Implementing Responsibility Centre Budgeting

    Science.gov (United States)

    Vonasek, Joseph

    2011-01-01

    Recently, institutes of higher education (universities) have shown a renewed interest in organisational structures and operating methodologies that generate productivity and innovation; responsibility centre budgeting (RCB) is one such process. This paper describes the underlying principles constituting RCB, its origin and structural elements, and…

  13. The GSO Data Centre

    CERN Document Server

    Paletou, F; Génot, V; Rouillard, A; Petit, P; Palacios, A; Caux, E; Wakelam, V

    2015-01-01

    Hereafter we describe the activities of the $Grand \\, Sud-Ouest$ Data Centre operated for INSU/CNRS by the OMP-IRAP and the Universit\\'e Paul Sabatier (Toulouse), in a collaboration with the OASU-LAB (Bordeaux) and OREME-LUPM (Montpellier).

  14. Implementing Responsibility Centre Budgeting

    Science.gov (United States)

    Vonasek, Joseph

    2011-01-01

    Recently, institutes of higher education (universities) have shown a renewed interest in organisational structures and operating methodologies that generate productivity and innovation; responsibility centre budgeting (RCB) is one such process. This paper describes the underlying principles constituting RCB, its origin and structural elements, and…

  15. ATLAS Visitors Centre

    CERN Multimedia

    claudia Marcelloni

    2009-01-01

    ATLAS Visitors Centre has opened its shiny new doors to the public. Officially launched on Monday February 23rd, 2009, the permanent exhibition at Point 1 was conceived as a tour resource for ATLAS guides, and as a way to preserve the public’s opportunity to get a close-up look at the experiment in action when the cavern is sealed.

  16. PATTERNS OF BREAST LESIONS IN PATIENTS ATTENDING CIMS, BILASPUR, C. G.: A RETROSPECTIVE TERTIARY HOSPITAL BASED STUDY

    Directory of Open Access Journals (Sweden)

    Arya

    2015-09-01

    Full Text Available The present study is designed to find out frequency of various histological patterns of breast lesions in patients attending Chhattisgarh Institute of Medical Sciences (CIMS, a teaching institute in Bilaspur Chhattisgarh and their biopsy samples studied i n department of pathology. A retrospective series study was conducted on 335 cases of breast lesions, reported from 2003 to 2014. Mean age of the subjects was 49.65 years with standard deviation 12.06 years, ranging from 12 to 75 years. In a total 335 cases, 40 (11.94% were non - neoplastic and 295(88.06% were neoplastic. Among neoplastic lesion s, 180(53.73% were benign, 02 (0.59% borderline and 113(33.73% found malignant. The commonest non - neoplastic lesion was fibrocystic disease of breast followed b y fibroadenosis and sclerosing adenosis. Neoplastic lesions were more common than non - neoplastic lesions. Among histological types of breast tumours, fibroadenoma dominated the other types. Thus commonest benign tumour was fibroadenoma followed by phyllode s tumour and commonest malignant was infiltrating duct carcinoma followed by medullary carcinoma. The commonest borderline tumour was phyllodes tumour with borderline changes.

  17. Town Centre Redevelopment Strategies

    DEFF Research Database (Denmark)

    Vagnby, Bo Hellisen

    as slum clearence and urban renewal. To a certain extent parallels are drawn to international experiences, especially where these are of such a nature that they can be assumed transferred to Danish connctions. Conclusively, the strategies are discussed in the light of the turn of Danish urban planning...... urban planning and design strategieswhich have been practised in most of the larger Danish towns: pedestrian streets, shopping centres, preservation of historic features, waterfronts, concentration of offices, conference and sports facilities, improvement og traffic and transport conditions as well...... during late years, where increased internationalisation is in focus and where it seems as if the social dimension of the town centre planning is slipping out of the hands of the urban planners....

  18. Elderly Care Centre

    Science.gov (United States)

    Wagiman, Aliani; Haja Bava Mohidin, Hazrina; Ismail, Alice Sabrina

    2016-02-01

    The demand for elderly centre has increased tremendously abreast with the world demographic change as the number of senior citizens rose in the 21st century. This has become one of the most crucial problems of today's era. As the world progress into modernity, more and more people are occupied with daily work causing the senior citizens to lose the care that they actually need. This paper seeks to elucidate the best possible design of an elderly care centre with new approach in order to provide the best service for them by analysing their needs and suitable activities that could elevate their quality of life. All these findings will then be incorporated into design solutions so as to enhance the living environment for the elderly especially in Malaysian context.

  19. Call centres: constructing flexibility

    OpenAIRE

    Arzbächer, Sandra; Holtgrewe, Ursula; Kerst, Christian

    2002-01-01

    "The development of call centres as a flexible interface between firms and their environments has been seen as exemplary or even symptomatic of flexible capitalism (Sennett 1998). We are going to point out that they do not just stand for organisational change but also for changes of institutions towards deregulation. Employers and managers hoped for gains of flexibility, decreasing labour costs, and market gains by an expanded 24-hour-service. Surveillance and control by flexib...

  20. Historical centres: changing definitions

    Directory of Open Access Journals (Sweden)

    Roberta Lazzarotti

    2014-02-01

    Full Text Available Since the end of the Second World War, the architectural and planning culture has been showing a fluctuating attention to the theme of historical centres and their enhancement. First of all this uneven progress explains the difficulty to reach a homogeneous definition and this is still lacking. During a long phase of this period, the historical parts of the town were considered as objects to be preserved in an integral way, as urban monuments. This is mostly due to the high symbolic value of these settlements, that represent fundamental landmarks. Identity building and empowerment of local communities are indispensable conditions for any development programme, especially in the case of centres or other historic environments at risk of abandonment. The progressive evolution of this concept brings awareness of the impossibility of separating – either in analytical or in planning terms ­ historical centres from their urban and territorial contexts, which are linked by mutual, deep relationships. This article attempts to retrace the steps signaled by the publication of international documents and conventions, from the Charter of Gubbio (1960 to the Charter of Krakow and the European Landscape Convention (2000; they obviously represent particular points of view, not exhaustive of the richness of the positions in the debate, but extremely significant in terms of diffusion and consensus.

  1. The Hierarchy Model of the Size Distribution of Centres

    NARCIS (Netherlands)

    J. Tinbergen (Jan)

    1968-01-01

    textabstractWe know that human beings live in centres, that is, cities, towns and villages of different size. Both large and small centres have a number of advantages and disadvantages, different for different people and this is why we have a whole range of sizes. Statistically, we even find that th

  2. Tele-centres in Ghana

    DEFF Research Database (Denmark)

    Falch, Morten

    2004-01-01

    Tele-centres offer a low cost opportunity for the many who cannot afford their own phone or Internet connection. This paper presents a field study of tele-centres in Ghana and analyses how they contribute to universal access.......Tele-centres offer a low cost opportunity for the many who cannot afford their own phone or Internet connection. This paper presents a field study of tele-centres in Ghana and analyses how they contribute to universal access....

  3. Alternativa terapeutica en la isquemia cerebral empleando la Eritropoyetina humana recombinante (rHu-EPO CIM como neuroprotector.

    Directory of Open Access Journals (Sweden)

    Iliana Sosa Testé

    2005-01-01

    Full Text Available Las enfermedades vasculares constituyen las terceras causas de muerte en Cuba. Su variante isquémica es causa de invalidez y perdida de la calidad de la vida. La búsqueda de agentes neuroprotectores es muy importante sí tenemos en cuenta que nuestra población está envejecida. Muchos son las razones por la que una molécula con propiedades neuroprotectoras en los modelos animales no tenga los resultados en ensayos clínicos en humanos. Este trabajo analiza y discute como mejorar estos aspectos. La Eritropoyetina humana recombinante (rHu EPO, conocido por su papel en la diferenciación del eritrocito, ha mostrado ser neuroprotector durante la isquemia cerebral en los modelos de animales adultos. De esta molécula se exponen los mecanismos de acción, que son las bases de los resultados positivos alcanzaron en las investigaciones preclínicas y los ensayos clínicos, que lo proponen como el neuroprotector ideal. Finalmente se comparan los resultados alcanzados por los autores en las investigaciones con la rHu EPO producida por el Centro Molecular de Inmunología de Cuba (CIM. El efecto de la aplicación de rHu EPO se evidenció por la disminución del edema cerebral, preservación de la conducta exploratoria y la disminución de la incidencia de señales clínicas de infarto cerebral y alteraciones patológicas. El grupo de resultados demostró las diferencias significantes entre los animales controles y tratados con el rHu EPO con los no tratados que sugieren que el rHu EPO debe ser considerado como una alternativa terapéutica contra el infarto cerebral en su fase aguda.

  4. Application of the Detrended Fluctuation Analysis method to the trajectory of the centre of pressure of the human body; Aplicacion del metodo Detrended Fluctuation Analysis a la trayectoria del centro de presion del cuerpo humano

    Energy Technology Data Exchange (ETDEWEB)

    Blazquez, M. T.; Anguiano, M.; Arias de Saavedra, F.; Lallena, A. M.; Carpena, P.

    2009-07-01

    The Detrended Fluctuation Analysis is a signal analyzing method which permits to study the correlation properties of the signal analyzed. This algorithm admits different variants which can be used to eliminate trends of different order existing in the signal. In this work we show the results obtained when two of these different variants, the so-called DFA-1 and DFA-2, are applied to the time series of the position and velocity of the centre of pressure of the human body in static conditions. The results show that the correlation exponents {alpha} obtained for each of the four types of analysis performed, depend on the scale studied. For the scales corresponding to large time intervals (above 35 s) the {alpha} values found in the four analyses coincide. (Author) 24 refs.

  5. Town Centre Redevelopment Strategies

    DEFF Research Database (Denmark)

    Vagnby, Bo Hellisen

    After many years of urban growth Danish downtowns are facing some important choices. Shall the stake one-sidedly be on the town centres as driving forces for growth and 'city marketing', or do they still have a role to play in a broader socio-economic context? In the paper we look back on eight...... as slum clearence and urban renewal. To a certain extent parallels are drawn to international experiences, especially where these are of such a nature that they can be assumed transferred to Danish connctions. Conclusively, the strategies are discussed in the light of the turn of Danish urban planning...

  6. Human Capital Formation and Foreign Direct Investment in Developing Countries. OECD Development Centre Working Paper No. 211 (Formerly Technical Paper No. 211)

    Science.gov (United States)

    Miyamoto, Koji

    2003-01-01

    This paper synthesises the existing literature on human capital formation and foreign direct investment (FDI) in developing countries. The aim is to take a bird's eye view of the complex linkages between the activities of multinational enterprises (MNEs) and policies of host developing countries. In doing so, general trends, best practices and…

  7. Aqueous-phase photooxidation of levoglucosan - a mechanistic study using aerosol time-of-flight chemical ionization mass spectrometry (Aerosol ToF-CIMS)

    Science.gov (United States)

    Zhao, R.; Mungall, E. L.; Lee, A. K. Y.; Aljawhary, D.; Abbatt, J. P. D.

    2014-09-01

    Levoglucosan (LG) is a widely employed tracer for biomass burning (BB). Recent studies have shown that LG can react rapidly with hydroxyl (OH) radicals in the aqueous phase despite many mass balance receptor models assuming it to be inert during atmospheric transport. In the current study, aqueous-phase photooxidation of LG by OH radicals was performed in the laboratory. The reaction kinetics and products were monitored by aerosol time-of-flight chemical ionization mass spectrometry (Aerosol ToF-CIMS). Approximately 50 reaction products were detected by the Aerosol ToF-CIMS during the photooxidation experiments, representing one of the most detailed product studies yet performed. By following the evolution of mass defects of product peaks, unique trends of adding oxygen (+O) and removing hydrogen (-2H) were observed among the products detected, providing useful information for determining potential reaction mechanisms and sequences. Additionally, bond-scission reactions take place, leading to reaction intermediates with lower carbon numbers. We introduce a data analysis framework where the average oxidation state (OSc) is plotted against a novel molecular property: double-bond-equivalence-to-carbon ratio (DBE/#C). The trajectory of LG photooxidation on this plot suggests formation of polycarbonyl intermediates and their subsequent conversion to carboxylic acids as a general reaction trend. We also determined the rate constant of LG with OH radicals at room temperature to be 1.08 ± 0.16 × 109 M-1 s-1. By coupling an aerosol mass spectrometer (AMS) to the system, we observed a rapid decay of the mass fraction of organic signals at mass-to-charge ratio 60 (f60), corresponding closely to the LG decay monitored by the Aerosol ToF-CIMS. The trajectory of LG photooxidation on a f44-f60 correlation plot matched closely to literature field measurement data. This implies that aqueous-phase photooxidation might be partially contributing to aging of BB particles in the

  8. Aqueous-phase photooxidation of levoglucosan - a mechanistic study using Aerosol Time of Flight Chemical Ionization Mass Spectrometry (Aerosol-ToF-CIMS)

    Science.gov (United States)

    Zhao, R.; Mungall, E. L.; Lee, A. K. Y.; Aljawhary, D.; Abbatt, J. P. D.

    2014-04-01

    Levoglucosan (LG) is a widely employed tracer for biomass burning (BB). Recent studies have shown that LG can react rapidly with hydroxyl (OH) radicals in the aqueous phase, despite many mass balance receptor models assuming it to be inert during atmospheric transport. In the current study, aqueous-phase photooxidation of LG by OH radicals was performed in the laboratory. The reaction kinetics and products were monitored by Aerosol Time of Flight Chemical Ionization Mass Spectrometry (Aerosol-ToF-CIMS). Approximately 50 reaction products were detected by the Aerosol-ToF-CIMS during the photooxidation experiments, representing one of the most detailed product studies yet performed. By following the evolution of mass defects of product peaks, unique trends of adding oxygen (+O) and removing hydrogen (-2H) were observed among the products detected, providing useful information to determine potential reaction mechanisms and sequences. As well, bond scission reactions take place, leading to reaction intermediates with lower carbon numbers. We introduce a data analysis framework where the average oxidation state (OSc) is plotted against a novel molecular property: double bond equivalence to carbon ratio (DBE / #C). The trajectory of LG photooxidation on this plot suggests formation of poly-carbonyl intermediates and their subsequent conversion to carboxylic acids as a general reaction trend. We also determined the rate constant of LG with OH radicals at room temperature to be 1.08 ± 0.16 × 109 M-1 s-1. By coupling an Aerosol Mass Spectrometer (AMS) to the system, we observed a rapid decay of the mass fraction of organic signals at mass-to-charge ratio 60 (f60), corresponding closely to the LG decay monitored by the Aerosol-ToF-CIMS. The trajectory of LG photooxidation on a f44-f60 correlation plot matched closely to literature field measurement data. This implies that aqueous-phase photooxidation might be partially contributing to aging of BB particles in the ambient

  9. The 3D trajectory of the body centre of mass during adult human walking: evidence for a speed-curvature power law.

    Science.gov (United States)

    Tesio, Luigi; Rota, Viviana; Perucca, Laura

    2011-02-24

    During straight walking, the body centre of mass (CM) follows a 3D figure-of-eight ("bow-tie") trajectory about 0.2 m long and with sizes around 0.05 m on each orthogonal axis. This was shown in 18 healthy adults walking at 0.3 to 1.4 ms⁻¹ on a force-treadmill (Tesio and Rota, 2008). Double integration of force signals can provide both the changes of mechanical energy of the CM and its 3D displacements (Tesio et al., 2010). In the same subjects, the relationship between the tangential speed of the CM, Vt, the curvature, C, and its inverse--the radius of curvature, r(c), were analyzed. A "power law" (PL) model was applied, i.e. logVt was regressed over logr(c). A PL is known to apply to the most various goal-directed planar movements (e.g. drawing), where the coefficient of logr(c), β, usually takes values around 13. When the PL was fitted to the whole dataset, β was 0.346 and variance explanation, R², was 59.8%. However, when the data were split into low- and high-curvature subsets (LC, HC, arbitrary cut-off of C=0.05 mm⁻¹, r(c)=20mm), β was 0.185 in the LC (R² 0.214) and 0.486 in the HC (R² 0.536) tracts. R² on the whole dataset increased to 0.763 if the LC-HC classification of the forward speed and their interaction entered the model. The β coefficient, the curvature C, and the pendulum-like recovery of mechanical energy were lower during the double foot-ground contact phase, compared to the single contact. Along the CM trajectory, curvature and muscle power output peaked together around the inversions of lateral direction. Non-zero torsion values were randomly distributed along 60% of the trajectory, suggesting that this is not segmented into piecewise planar tracts. It is proposed that the trajectory can be segmented into one tract that is more actively controlled (tie) where a PL fits poorly and another tract which is more ballistic (bow) where a PL fits well. Results need confirmation through more appropriate 3D PL modelling. Copyright © 2010

  10. Development of L-histidine immobilized CIM(®) monolithic disks for purification of immunoglobulin G.

    Science.gov (United States)

    Prasanna, Rajasekar R; Kamalanathan, Agamudi S; Vijayalakshmi, Mookambeswaran A

    2015-03-01

    The pseudobiospecific affinity ligand l-histidine was immobilized on epoxy, carbonyldiimidazole (CDI), and ethylenediamine (EDA) convective interaction media (BIA Separations, Slovenia) monolithic disks to obtain the histidyl affinity column for purification of immunoglobulin G (IgG). The kinetics and the mass transfer properties of the affinity columns were studied to determine the optimum buffer condition, flow rate, and concentration of IgG for maximum IgG adsorption. The binding capacities of all the three affinity columns were higher with zwitterionic buffer morpholinopropanesulfonic acid than with charged buffers such as tris-HCl and phosphate buffers, and the optimum pH was 6.5. The interaction of IgG with histidine immobilized CDI and epoxy disks was found to be predominantly driven by ionic interaction, while the interaction with EDA-histidine disk could be partially governed by multiple non-covalent forces of interaction. The maximum binding capacity (Qm ) of l-histidine immobilized on EDA-, CDI-, and epoxy-activated convective interaction media disks were 19.83 ± 0.25, 15.85 ± 0.18 and 12.11 ± 0.17 mg/ml of support, respectively, and the dissociation constant (Kd ) were calculated to be in the micromolar range for all the three histidyl monolithic columns. Purification of IgG from untreated human serum was also attempted, and the results indicate the high potential of this method for purification of total IgG from complex biological sources and also for separation of IgG1 from other subclasses.

  11. 石油化工领域CIMS体系结构研究%Research of CIMS Architecture in the Petrochemical Field

    Institute of Scientific and Technical Information of China (English)

    张玉梅; 郭景峰

    2001-01-01

    以大庆石化总厂化工一厂的CIMS示范工程为例,论述石油化工领域计算机集成生产系统(Computer Integrated Manufacturing System, CIMS)的体系结构;以CIMS原理为指导,把CIMS工程的目标与企业长远发展战略相结合,给出了适合我国石油化工行业要求的CIMS的实施方案.

  12. Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil

    Directory of Open Access Journals (Sweden)

    Albert Eduardo Silva Martins

    2014-09-01

    Full Text Available Human immunodeficiency virus (HIV-positive patients have a greater prevalence of coinfection with human papillomavirus (HPV is of high oncogenic risk. Indeed, the presence of the virus favours intraepithelial squamous cell lesion progression and may induce cancer. The aim of this study was to evaluate the prevalence of HPV infection, distribution of HPV types and risk factors among HIV-positive patients. Cervical samples from 450 HIV-positive patients were analysed with regard to oncotic cytology, colposcopy and HPV presence and type by means of polymerase chain reaction and sequencing. The results were analysed by comparing demographic data and data relating to HPV and HIV infection. The prevalence of HPV was 47.5%. Among the HPV-positive samples, 59% included viral types of high oncogenic risk. Multivariate analysis showed an association between HPV infection and the presence of cytological alterations (p = 0.003, age greater than or equal to 35 years (p = 0.002, number of partners greater than three (p = 0.002, CD4+ lymphocyte count < 200/mm3 (p = 0.041 and alcohol abuse (p = 0.004. Although high-risk HPV was present in the majority of the lesions studied, the low frequency of HPV 16 (3.3%, low occurrence of cervical lesions and preserved immunological state in most of the HIV-positive patients were factors that may explain the low occurrence of precancerous cervical lesions in this population.

  13. Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil.

    Science.gov (United States)

    Martins, Albert Eduardo Silva; Lucena-Silva, Norma; Garcia, Renan Gomes; Welkovic, Stefan; Barboza, Aureliana; Menezes, Maria Luiza Bezerra; Maruza, Magda; Tenório, Terezinha; Ximenes, Ricardo A A

    2014-09-01

    Human immunodeficiency virus (HIV)-positive patients have a greater prevalence of coinfection with human papillomavirus (HPV) is of high oncogenic risk. Indeed, the presence of the virus favours intraepithelial squamous cell lesion progression and may induce cancer. The aim of this study was to evaluate the prevalence of HPV infection, distribution of HPV types and risk factors among HIV-positive patients. Cervical samples from 450 HIV-positive patients were analysed with regard to oncotic cytology, colposcopy and HPV presence and type by means of polymerase chain reaction and sequencing. The results were analysed by comparing demographic data and data relating to HPV and HIV infection. The prevalence of HPV was 47.5%. Among the HPV-positive samples, 59% included viral types of high oncogenic risk. Multivariate analysis showed an association between HPV infection and the presence of cytological alterations (p = 0.003), age greater than or equal to 35 years (p = 0.002), number of partners greater than three (p = 0.002), CD4⁺ lymphocyte count < 200/mm³ (p = 0.041) and alcohol abuse (p = 0.004). Although high-risk HPV was present in the majority of the lesions studied, the low frequency of HPV 16 (3.3%), low occurrence of cervical lesions and preserved immunological state in most of the HIV-positive patients were factors that may explain the low occurrence of precancerous cervical lesions in this population.

  14. Stavanger Squash Centre, Norway

    Energy Technology Data Exchange (ETDEWEB)

    Rostvik, H. [Sunlab/ABB, Stavanger (Norway)

    1999-07-01

    Although Stavanger is the technological and financial oil-capital of Norway, the Stavanger Squash Centre was until recently the largest solar building in Norway, with 120 m{sup 2} of collectors. The active, building-integrated, solar air collector in the 45 {sup o} roof facing 15 {sup o} east of due south, has now been delivering solar-heated hot water for the showers for 15 years. The solar system consists of several standard products put together in a new way. Monitoring has shown that the system produced 18,000 kWh/m{sup 2} a (150 kWh/m{sub coll} {sup 2}a). If operated as planned, it could have had a solar contribution of 45,000 kWh/a) (375 kWh/m{sub coll} {sup 2}a), resulting in a 19% solar fraction of total demand. (author)

  15. A cancer help centre.

    Science.gov (United States)

    Daniel, R

    1996-06-01

    The diagnosis of cancer can be shattering to all involved. The treatment of cancer is intense and often very challenging. Prevailing attitudes to cancer are sometimes fearful, negative and depressing. This combination may leave those affected by cancer shocked, disorientated and without hope. Even worse than this, on asking consultants 'What can I do to help myself?' patients are frequently told 'Absolutely nothing'--crushing in one fell swoop their remaining fighting spirit. Not so in the case of Penny Brohn, who, when faced with the diagnosis of breast cancer, travelled the world to find alternative cancer treatments, and having successfully brought her own cancer under control, dedicated her life to creating a Centre for others wishing to fight their disease.

  16. Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA

    Science.gov (United States)

    de Boni, Laura; Saverioni, Daniela; Cohen, Mark L.; Ferrer, Isidro; Gambetti, Pierluigi; Gelpi, Ellen; Giaccone, Giorgio; Hauw, Jean-Jacques; Höftberger, Romana; Ironside, James W.; Jansen, Casper; Kovacs, Gabor G.; Rozemuller, Annemieke; Seilhean, Danielle; Tagliavini, Fabrizio; Giese, Armin

    2013-01-01

    The current classification of human sporadic prion diseases recognizes six major phenotypic subtypes with distinctive clinicopathological features, which largely correlate at the molecular level with the genotype at the polymorphic codon 129 (methionine, M, or valine, V) in the prion protein gene and with the size of the protease-resistant core of the abnormal prion protein, PrPSc (i.e. type 1 migrating at 21 kDa and type 2 at 19 kDa). We previously demonstrated that PrPSc typing by Western blotting is a reliable means of strain typing and disease classification. Limitations of this approach, however, particularly in the interlaboratory setting, are the association of PrPSc types 1 or 2 with more than one clinicopathological phenotype, which precludes definitive case classification if not supported by further analysis, and the difficulty of fully recognizing cases with mixed phenotypic features. In this study, we tested the inter-rater reliability of disease classification based only on histopathological criteria. Slides from 21 cases covering the whole phenotypic spectrum of human sporadic prion diseases, and also including two cases of variant Creutzfeldt–Jakob disease (CJD), were distributed blindly to 13 assessors for classification according to given instructions. The results showed good-to-excellent agreement between assessors in the classification of cases. In particular, there was full agreement (100 %) for the two most common sporadic CJD subtypes and variant CJD, and very high concordance in general for all pure phenotypes and the most common subtype with mixed phenotypic features. The present data fully support the basis for the current classification of sporadic human prion diseases and indicate that, besides molecular PrPSc typing, histopathological analysis permits reliable disease classification with high interlaboratory accuracy. PMID:22744790

  17. MISSING CASES OF CANCER CERVIX IN NEWLY STARTED OUT PATIENT DEPARTMENT OF RADIOTHERAPY, CIMS, BILASPUR (C. G.

    Directory of Open Access Journals (Sweden)

    Hemlata

    2015-10-01

    Full Text Available BACKGROUND: C ancer of the cervix is the second most common cancer among women’s worldwide. In India also, cancer of cervix is second most common cancer among women’s and number one killer. Estimated incidence rate of 22/lac population . [1] C ancer cervix is difficult to cure once symptoms developed. Prognosis is strongly dependent upon the stage of cancer at the time of detection and treatment. In our institute CIMS, Bilaspur (C. G. newly form cancer unit start providing services from August 2013. In our Hospital registry a cross - sectional base line data were collected, it was eye opener that proportion of cancer of cervix registry are less as compared nationwide HBCR & PBCR programme. OBJECTIVE : 1. To find out the reason for low registration of cancer cervix cases in OPD of cancer Unit. 2. To developed / suggest appropriated screening program. MATERIAL AND METHOD S : Retrospective study was carried out to collect all information from - Year 2012 to June 2 015, from medical records & Registers of department of pathology, department of Obstratric & Gynaecology and Medical Record Department, information collected regarding cancer cervix patient in semi structured format and analysed by SPSS software to inquire about cancer of cervix patient. STATISTICAL ANALYSIS : Using SPSS software 11.5 version. Statistic were reported in form of frequency and percentages. RESULT : In this present study out of total diagnosed cervical cancer cases in our institute only 61.11% c ases reach up to radiotherapy department for registration and 38.88% cases are lost during referral and follow - up . Yield of cancer cervix screening camp was only 5.75% and OPD based screening 22.89% with cervical smear cytology, both figure are quit low as cytology is estimated to have a mean sensitivity of 58% and specificity of 69 % [2] both sampling and detection error probably contribute to low to moderate sensitivity of cytology. CONCLUSION: C oordination between

  18. Call Centre- Computer Telephone Integration

    Directory of Open Access Journals (Sweden)

    Dražen Kovačević

    2012-10-01

    Full Text Available Call centre largely came into being as a result of consumerneeds converging with enabling technology- and by the companiesrecognising the revenue opportunities generated by meetingthose needs thereby increasing customer satisfaction. Regardlessof the specific application or activity of a Call centre, customersatisfaction with the interaction is critical to the revenuegenerated or protected by the Call centre. Physical(v, Call centreset up is a place that includes computer, telephone and supervisorstation. Call centre can be available 24 hours a day - whenthe customer wants to make a purchase, needs information, orsimply wishes to register a complaint.

  19. CLINICO - PATHOLOGICAL STUDY OF NON - NEOPLASTIC LESIONS IN SINO - NASAL CAVITY OF PATIENTS ATTENDING CIMS, BILASPUR (C. G.: A RETROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Arya

    2015-10-01

    Full Text Available INTRODUCTION : The present study examined the patterns of sinonasal masses in biopsies received in department of pathology of Govt. CIMS, Bilaspur which is a tertiary care hospital of central eastern region of India and represents a tribal belt. During the study period, 91 biopsied reported were retrieved from the records and results analyzed. OBJECTIVE : This study is designed to find out patterns of benign lesions of nasal mass in patients attending Chhattisgarh Institute of Medical Sciences (CIMS, a teaching institute in Bilaspur Chhattisgarh. MATERIAL AND METHODS : 91 nasal biopsy records of March 2003 to August 2015 were reviewed. All the biopsy samples of patients were received and studied in department of pathology. RESULTS AND OBSERVATIONS : Average age of subjects reported as non - neoplastic lesions is found 19.69 years with standard deviation of 9.44, ranging from 6 to 47 years. Among 75 non - neoplastic lesions, 63 (84.00% reported as rhinosporidiosis, 10(13.33% non - specific inflammatory po lyp and 2 were (2.67% tuberculosis. CONCLUSION : Rhinosporidiosis encountered as most common non - neoplastic lesion and most patients affected were in younger age groups. The study concluded with the exceptionally higher prevalence of rhinosporidiosis obser ved in this region

  20. Design and Implementation ofan Integrating Infrastructure forCIM Systems%一种CIM集成基础结构的设计与实现

    Institute of Scientific and Technical Information of China (English)

    邓胜春; 徐晓飞; 王念滨; 王刚

    2001-01-01

    Integrating infrastructure is the basic supportingenvironmentforCIM(computer integrated manu-facturing)systems.This paperintroduces the design and implementation ofan opening distributed CIM integrat-ing infrastructure,HIT-IIS.2,developed by HIT(Harbin Institute of Technology).The HIT-IIS.2 prototypeincludes the following service functions for CIM systems:business process control,enterprise activity control,resource management,definition and description,system information,communication managementand front-endinterface.Each service function is described in the paper.%在计算机集成制造系统中,CIM(computer integratedmanufacturing)集成基础结构是最主要的支撑环境之一.介绍了由哈尔滨工业大学设计和开发的开放式CIM集成基础结构——HIT-IIS.2.该原型系统为CIM系统提供了以下一些服务功能:经营过程控制、企业活动控制、资源管理、定义描述与维护、全局系统信息服务、通信管理以及系统前端接口等.详细描述其中的每一服务功能

  1. The Application of CIMS in Production Management for Shipbuilding%CIMS在造船生产管理中的应用

    Institute of Scientific and Technical Information of China (English)

    赵勇

    2012-01-01

    CIMS is short for the computer information management system, which has been widely applied to the field of modern manufacturing since 1990s. Shipbuilding industry is the area of strong planning. Especially in the depressed market environment and the fierce competition among enterprises, how to use modern tools, allocate the resource and seek for benefit is one of the measures which every shipbuilding enterprise has to take. Based on our company's actual application condition, this paper briefly describes the application of CIMS in the production management for shipbuilding.%CIMS是计算机集成制造系统的简称,上世纪九十年代起已经开始广泛应用于现代制造领域,而造船行业则属于计划性比较强的领域,尤其是在目前市场环境比较低迷,企业间竞争比较激烈的情况下,如何利用现代化的工具,做好资源调配,从管理中挖掘效益,是各个造船企业必将采取的手段之一,本文结合我公司的实际使用情况对此进行简要说明。

  2. Should "Teacher Centred Teaching" Replace "Student Centred Learning"?

    Science.gov (United States)

    Bailey, Patrick D.

    2008-01-01

    Mission statements of most HEIs across the UK support "student centred learning". In this paper, it is suggested that "teacher centred teaching" should also have a major role to play, improving the quality of the learning experience in higher education. Students are extremely diverse in their skills, weaknesses, and learning…

  3. Council celebrates CERN Control Centre

    CERN Multimedia

    2006-01-01

    With the unveiling of its new sign, the CERN Control Centre was officially inaugurated on Thursday 16 March. To celebrate its startup, CERN Council members visited the sleek centre, a futuristic-looking room filled with a multitude of monitoring screens.

  4. Cell Centred Database (CCDB)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Cell Centered Database (CCDB) is a web accessible database for high resolution 2D, 3D and 4D data from light and electron microscopy, including correlated imaging.

  5. CMCC Data Distribution Centre

    Science.gov (United States)

    Aloisio, Giovanni; Fiore, Sandro; Negro, A.

    2010-05-01

    The CMCC Data Distribution Centre (DDC) is the primary entry point (web gateway) to the CMCC. It is a Data Grid Portal providing a ubiquitous and pervasive way to ease data publishing, climate metadata search, datasets discovery, metadata annotation, data access, data aggregation, sub-setting, etc. The grid portal security model includes the use of HTTPS protocol for secure communication with the client (based on X509v3 certificates that must be loaded into the browser) and secure cookies to establish and maintain user sessions. The CMCC DDC is now in a pre-production phase and it is currently used only by internal users (CMCC researchers and climate scientists). The most important component already available in the CMCC DDC is the Search Engine which allows users to perform, through web interfaces, distributed search and discovery activities by introducing one or more of the following search criteria: horizontal extent (which can be specified by interacting with a geographic map), vertical extent, temporal extent, keywords, topics, creation date, etc. By means of this page the user submits the first step of the query process on the metadata DB, then, she can choose one or more datasets retrieving and displaying the complete XML metadata description (from the browser). This way, the second step of the query process is carried out by accessing to a specific XML document of the metadata DB. Finally, through the web interface, the user can access to and download (partially or totally) the data stored on the storage device accessing to OPeNDAP servers and to other available grid storage interfaces. Requests concerning datasets stored in deep storage will be served asynchronously.

  6. High concentrations of N2O5 and NO3 observed in daytime with a TD-CIMS: chemical interference or a real atmospheric phenomenon?

    Directory of Open Access Journals (Sweden)

    X. Wang

    2013-08-01

    Full Text Available Dinitrogen pentoxide (N2O5 and the nitrate radical (NO3 play important roles in atmospheric chemistry, yet accurate measurements of their concentrations remain challenging. A thermal dissociation chemical ionization mass spectrometer (TD-CIMS was deployed to an urban site in Hong Kong to measure the sum of N2O5 and NO3 in autumn 2010. To our surprise, very high concentrations of N2O5 + NO3 were frequently observed in daytime, with mixing ratios in the range of 200–1000 pptv. To investigate this unusual phenomenon, various interference tests and measurements with different instrument configuration were conducted. It was found that peroxy acetyl nitrate (PAN contributed to measurable signals at 62 amu, and more importantly, this interference increased significantly with co-existence of NO2. Nitric acid (HNO3, on the other hand, had little interference to the detection of N2O5/NO3 via the NO3− ion in our TD-CIMS. According to the test results, the interference from PAN and NO2 could have contributed to 30–50% of the average daytime (12:00–16:00 LT N2O5 + NO3 signal at our site. However, evidence exists for the presence of elevated daytime N2O5, in addition to the daytime signal at 62 amu. This includes: (1 daytime N2O5 measured via the I(N2O5− cluster ion with an unheated inlet, which subjects to minimum interferences, and (2 observation of elevated daytime ClNO2 (a product of N2O5 hydrolysis during a follow-up study. In view of the difficulty in accurately quantifying the contribution from the interferences of PAN and NO2 and un-tested potential interfering chemicals in the real atmosphere, we caution the use of 62 amu in the TD-CIMS for measuring ambient N2O5 in a high NOx environment like Hong Kong. Additional studies are needed to re-examine the daytime issue using other measurement techniques.

  7. Minister unveils new nanotech centres

    Science.gov (United States)

    Dumé, Belle

    2009-06-01

    Three new nanotechnology research centres are to be set up in France as part of a €70m government plan to help French companies in the sector. Researchers at the new centres, which will be located in Grenoble, Saclay (near Paris) and Toulouse, will be encouraged to collaborate with industry to develop new nanotech-based products. Dubbed NANO-INNOV, the new plan includes €46m for two new buildings at Saclay, with the rest being used to buy new equipment at the three centres and to fund grant proposals from staff to the French National Research Agency (ANR).

  8. 25 years Nuclear Research Centre

    Energy Technology Data Exchange (ETDEWEB)

    Harde, R.

    1981-07-01

    On June 12, the Karlsruhe Nuclear Research Centre celebrated its 25th anniversary. The Centre was founded on July 19, 1956. The importance of this institution became apparent by the large number of prominent guests, at the head, the Federal President, Karl Carstens. Minister President Spaeth and the Federal Minister for Research and Technology, von Buelow, appreciated the achievements obtained by this big science centre of nuclear technology. The ceremony held in the State theatre of Baden-Wuerttemberg gave testimony of an impressing confession in favour of nuclear energy. Excerpts from the speech of the Chairman of the Managing Board, Prof. Harde, are quoted.

  9. The World Heritage Centr

    Directory of Open Access Journals (Sweden)

    Ayman G. Abdel Tawab

    2014-09-01

    Full Text Available New Gourna Village, which is located inside one of the World Heritage Sites in Egypt, has never been recognized as an element contributing to the site’s Outstanding Universal Value. The recognition of the village as a contributing element is reliant on the successful assessment of its authenticity and integrity. Responding to the dramatically declining integrity of the village, the World Heritage Centre has carried out an architectural study to guide the potential conservation works in the property. The study has recommended that a group of objectives and two approaches to the conservation of the village should be adopted. One of these two approaches has been concerned with the conservation of the village according to the architect’s original intentions and principles. The previous approach can be called the principles-based approach. The main aim of this study was to examine the agreement of the World Heritage Centre’s objectives and their proposed principles-based approach to the conservation of the village with the aim to improve its chance in meeting the conditions of authenticity and integrity. The study approached the previous aim by assessing, by means of a proposed methodology; the level of significance, authenticity and integrity of the property. Based on the previous assessment, a list of conservation interventions was proposed to improve the property’s chance in meeting the conditions of authenticity and integrity. Finally, the World Heritage Centre’s recommended approaches and objectives were examined against the previous proposed conservation interventions. The findings indicated the possibility to adopt the principles-based approach to the conservation of New Gourna Village, as well as the other World Heritage Centre’s objectives, without limiting the property’s chance in meeting the conditions of authenticity and integrity. The study recommends to carry out further studies that are concerned with the identification

  10. Research on CIMS Information Classification and Coding Based on OO%基于OO的CIMS信息分类编码研究

    Institute of Scientific and Technical Information of China (English)

    皮德常; 张凤林; 丁宗红; 王宁生

    2000-01-01

    A classification and coding system FCC links-oriented in CIMS is introduced.This method is based on the analysis of a lot of national and international classification and coding systems, the requirement of information integrated in CIMS and the object-oriented method. Firstly, we analyze the necessity of adopting OO (Object-oriented) method to construct this model and propose, a scheme composed of complex object O and operation M which is applied to the object O which is a 3-tuples describing object identifier, object feature and graph feature. Object identifier is a 2-tuples. The item of graph feature is a 4-tuples, which describes identifier ,sign, signature and files of the graph. Secondly, we propose the FCC structure description of classification and coding based on OO. In the structure, we use the links of field domain and super class / subclass, then we flat the complex object model into a relation, and the flatted relation structure can be described asobject identifier, registration and signature description. Thirdly, the system bottom adopts relation to implement the OO structure, which is compatible with the other coding system. The above-mentioned method provides a guarantee for data exchanging and sharing in CIMS. Finally, we believe that it is an indefinite and flexible levels and orients the signature of object, it effectively solves the problem to classification and information in CIMS.%通过分析国内外现有各分类编码系统以及CIMS对信息集成的要求,结合面向对象(Object-oriented,OO)方法提出了一种面向CIMS各环节的分类编码结构模型FCC。该模型由复杂对象O和施加于O上的操作M构成,其中O可描述为一个三元组,用于类别标识,事物特征描述和图形特征描述。类别标识项是一个可用二元组描述的复杂对象;图形特征项是一个四元组,描述了图形标识,图形符号,图形特征数据和图形文件;为描述FCC结构引人了属性域连

  11. 制造型企业的CIMS需求分析探究%Exploration on demand analysis of CIMS in manufacturing enterprise

    Institute of Scientific and Technical Information of China (English)

    张绪乾

    2011-01-01

    我国大部分制造型企业开发出的一些CIMS系统不能满足企业的需求,导致了CIMS工程的不同程度的风险和企业资源的浪费,企业要有效的实施CIMS,首先必须进行CIMS的需求分析,即在实施CIMS前必须详细地进行企业现状分析,找出企业存在的问题,以进行CIMS系统对策研究,并在湖北久隆公司实施CIMS应用工程的需求分析中进行了实践.

  12. LAS COMUNICACIONES INTEGRADAS DE MARKETING (CIM COMO PILAR DE LA ESTRATEGIA DE MARKETING VERDE Y SUS IMPLICACIONES EN LA GESTIÓN AMBIENTAL

    Directory of Open Access Journals (Sweden)

    NELCY ROCÍO ESCOBAR MORENO

    2012-01-01

    Full Text Available Este documento examina el constructo de Comunicaciones Integradas de Marketing (CIM, desde su definición hasta su aplicación a partir de la perspectiva del mercadeo verde en la estrategia organizacional. El texto presenta tres grandes discusiones, primero, una reflexión particular sobre los aportes e implicaciones más importantes de las Comunicaciones Integradas de Marketing y de cada uno de sus instrumentos a la estrategia de gestión ambiental de las organizaciones. Luego, una caracterización general del consumidor verde y de otros stakeholders de la organización, en particular, de su papel en el proceso estratégico de la comunicación verde. Finalmente, como conclusión de este trabajo, se plantean algunas consideraciones sobre la necesaria aplicación de este concepto en la propuesta de gestión ambiental organizacional en la actualidad.

  13. The Human Communication Research Centre dialogue database.

    Science.gov (United States)

    Anderson, A H; Garrod, S C; Clark, A; Boyle, E; Mullin, J

    1992-10-01

    The HCRC dialogue database consists of over 700 transcribed and coded dialogues from pairs of speakers aged from seven to fourteen. The speakers are recorded while tackling co-operative problem-solving tasks and the same pairs of speakers are recorded over two years tackling 10 different versions of our two tasks. In addition there are over 200 dialogues recorded between pairs of undergraduate speakers engaged on versions of the same tasks. Access to the database, and to its accompanying custom-built search software, is available electronically over the JANET system by contacting liz@psy.glasgow.ac.uk, from whom further information about the database and a user's guide to the database can be obtained.

  14. The centre of the action

    CERN Multimedia

    2008-01-01

    The CERN Control Centre (CCC) has all the ingredients of an action movie control room: hundreds of screens, technicians buzzing in and out, huge floor-to-ceiling windows revealing the looming vista of a mountain range, flashing lights, microphones… This is the place where not just the LHC, but the whole of CERN’s accelerator complex and technical support is based - truly the centre of the action at CERN.

  15. Simultaneous ground-based and airborne measurements of biogenic VOC oxidation products using iodide-adduct HR-ToF-CIMS in the Southeast U.S

    Science.gov (United States)

    Lee, B.; Mohr, C.; Lopez-Hilfiker, F.; Warneke, C.; Graus, M.; Gilman, J.; Lerner, B. M.; Pollack, I. B.; Ryerson, T. B.; Roberts, J. M.; Edwards, P. M.; Brown, S. S.; Holloway, J.; Aikin, K.; Dube, W. P.; Liao, J.; Welti, A.; Middlebrook, A. M.; Nowak, J. B.; Neuman, J. A.; Brioude, J. F.; McKeen, S. A.; Hanisco, T. F.; Kaiser, J.; Keutsch, F. N.; Wolfe, G. M.; Hallquist, M.; Trainer, M.; De Gouw, J. A.; Thornton, J. A.

    2013-12-01

    We present measurements by two high-resolution time-of-flight chemical-ionization mass spectrometers (HR-ToF-CIMS) during the Southeast Atmosphere Study in June and July of 2013. Both HR-ToF-CIMS used iodide as the reagent ion, which provides minimum fragmentation during ionization. Isoprene and monoterpene oxidation byproducts such as hydroxy hydroperoxides, carboxylic acids and organic nitrates, were ubiquitous in the mass spectra. In addition, we observed select inorganic gases such as N2O5 and ClNO2. The flight instrument was deployed aboard the NOAA WP-3D during SENEX, which explored the lower atmosphere over the Southeast U.S., logging a total of 125 flight hours. These measurements provide insight into the spatial and temporal variation of these types of compounds and the influence of natural gas fields, power plants, biomass burning, urban and biogenic emissions on their abundance under both day and nighttime conditions. The ground-based instrument was located near Brent, Alabama as part of the SOAS campaign and utilized the Filter Inlet for Gas and AEROsol (FIGAERO) - developed at the University of Washington - which allows measurement of both the gas and particle phases. Continuous observations spanning more than 4 weeks show the diurnal variability and the influence of meteorology and anthropogenic emissions on the gas-particle partitioning. Flights during SENEX over the ground site provide a unique opportunity to investigate the vertical distribution of a whole suite of these chemical species measured by these two cross-calibrated nearly identical instruments.

  16. CERN Control Centre Animations

    CERN Multimedia

    2014-01-01

    The LHC beam is formed of many bunches of particles (up to 2808), each measuring a few centimetres long and a millimetre wide. Their width is smaller than the size of Spain on a 1 Euro coin. However, the bunch size is not constant around the ring. Each bunch, as it circulates around the LHC, gets squeezed and expanded. It gets squeezed as much as possible around the interaction points to increase the probability of a collision. As they approach the collision points, they are squeezed to about 16 micrometers (a human hair is about 50 micrometers thick) to allow for a greater chance of collisions.

  17. Client Centred Design

    DEFF Research Database (Denmark)

    Ørngreen, Rikke; Nielsen, Janni; Tweddell Levinsen, Karin

    2004-01-01

    Abstract In this paper the Human Computer Interaction (HCI) Research Group reports on the pre-phase of an e-learning project, which was carried out in collaboration with the client. The project involved an initial exploration of the problem spaces, possibilities and challenges for an online accre......-users,) then it is possible to build on existing resources within the client organisation, leading to grounding of design decisions and a match between the e-learning environment designed and the capabilities of the client.......Abstract In this paper the Human Computer Interaction (HCI) Research Group reports on the pre-phase of an e-learning project, which was carried out in collaboration with the client. The project involved an initial exploration of the problem spaces, possibilities and challenges for an online...... accredited Continued Medical Education (CME) programme at the Lundbeck Institute. The CME programme aims at end-users, which are primarily general practitioners, but also specialists (psychiatrist and psychologists), from all over the world. The assumption was that it would be possible to identify and build...

  18. The ideal Atomic Centre; Le Centre Atomique ideal

    Energy Technology Data Exchange (ETDEWEB)

    Mas, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    The author presents considerations which should prove to be of interest to all those who have to design, to construct and to operate a nuclear research centre. A large number of the ideas presented can also be applied to non-nuclear scientific research centres. In his report the author reviews: various problems with which the constructor is faced: ground-plan, infrastructure, buildings and the large units of scientific equipment in the centre, and those problems facing the director: maintenance, production, supplies, security. The author stresses the relationship which ought to exist between the research workers and the management. With this aim in view he proposes the creation of National School for Administration in Research which would train administrative executives for public or private organisations; they would be specialised in the fields of fundamental or applied research. (author) [French] L'auteur propose une base de reflexions a tous ceux qui doivent concevoir, realiser et faire vivre un Centre d'Etudes Nucleaires. Un grand nombre des idees exprimees peut d'ailleurs s'appliquer a un Centre d'Etudes Scientifiques non nucleaires. Dans son ouvrage, l'auteur passe en revue les differents problemes qui se posent au constructeur: plan, masse, infrastructure, batiments et grands appareils du Centre, et ceux qu'a a resoudre le directeur: entretien, fabrication, approvisionnements, securite. L'auteur insiste sur l'aspect des rapports qui doivent exister entre les chercheurs et ceux qui les administrent. Il propose a cette fin la creation d'une Ecole Nationale d'Administration de la Recherche qui formerait des cadres administratifs pour les organismes publics ou prives, specialises dans la Recherche fondamentale ou appliquee. (auteur)

  19. The emergence of urban centres

    DEFF Research Database (Denmark)

    Lazaro, Evelyn; Agergaard, Jytte; Larsen, Marianne Nylandsted

    In this paper we aim at understanding how social and spatial transformation of dynamic rural regions is driving spatial concentration and urbanization. We are particularly concerned with the processes of spatial change, verbalized as the emergence of urban centres in rural areas. Emerging Urban...... Centres (EUCs) are characterized by rapid population growth related to continuous and diverse flows of migrants from rural hinterlands and more detached rural locations. Many of these centres are also characterized by economic dynamics related to agricultural sector activities that have been stimulated...... by Tanzanian market liberalizations and its long term effects on private enterprise. The paper is based on a study of four EUCs in Tanzania (Ilula, Igowole, Madizini and Kibaigwa) and seeks to answer three research questions: 1) What economic and spatial trends, including national policies, have formed...

  20. Person-centred reflective practice.

    Science.gov (United States)

    Devenny, Bob; Duffy, Kathleen

    Person-centred health and person-centred care have gained prominence across the UK following the publication of reports on public inquiries exploring failings in care. Self-awareness and participation in reflective practice are recognised as vital to supporting the person-centred agenda. This article presents an education framework for reflective practice, developed and used in one NHS board in Scotland, and based on the tenets of the clinical pastoral education movement. Providing an insight into the usefulness of a spiritual component in the reflective process, the framework provides an opportunity for nurses and other healthcare professionals to examine the spiritual dimensions of patient encounters, their own values and beliefs, and the effect these may have on their practice.

  1. Construction of the Wigner Data Centre

    CERN Multimedia

    2013-01-01

    A remote extension of the CERN data centre has recently been inaugurated. Hosted at the Wigner Research Centre for Physics in Hungary, it provides extra computing power required to cover CERN’s needs. This video presents the construction of the Wigner Data Centre from initial demolishing work through to its completion and details the major technical characteristics of the Data Centre.

  2. Construction of the Wigner Data Centre

    CERN Document Server

    2013-01-01

    A remote extension of the CERN data centre has recently been inaugurated. Hosted at the Wigner Research Centre for Physics in Hungary, it provides extra computing power required to cover CERN’s needs. This video presents the construction of the Wigner Data Centre from initial demolishing work through to its completion and details the major technical characteristics of the Data Centre.

  3. Scheduling participants of Assessment Centres

    DEFF Research Database (Denmark)

    Lysgaard, Jens; Løber, Janni

      Assessment Centres are used as a tool for psychologists and coaches to observe a number of dimensions in a person's behaviour and test his/her potential within a number of chosen focus areas. This is done in an intense course, with a number of different exercises which expose each participant...... Centres usually last two days and involve 3-6 psychologists or trained coaches as assessors. An entire course is composed of a number of rounds, with each round having its individual duration. In each round, the participants are divided into a number of groups with prespecifed pairing of group sizes...

  4. LDE centres: sprint or marathon?

    NARCIS (Netherlands)

    Bonger, S.; Van Rein, E.

    2015-01-01

    The aim of the Strategic Leiden-Delft-Erasmus Alliance, established by the three universities in 2012, was to improve research and education and competitiveness. Projects are intended to develop from the ground up, which led to the establishment of eight joint centres in 2013. A quick look around re

  5. FIGAERO ToF CIMS measurements of chlorine photochemical activation by nitryl chloride chemistry at a semi-rural site in Beijing

    Science.gov (United States)

    Le Breton, Michael; Hallquist, Åsa M.; Kant Pathak, Ravi; Simpson, David; Wang, Yujue; Zheng, Jing; Yang, Yudong; Shang, Dongjie; Wang, Haichao; Lu, Keding; Guo, Song; Hu, Min; Hallquist, Mattias

    2017-04-01

    Severe pollution events across China pose a major threat to air quality and climate through the direct emission of pollutants, but also via the production of photochemically induced secondary pollutants. Nitryl chloride (ClNO2), produced from heterogeneous reactions of dinitrogen pentoxide (N2O5) and aerosols containing chloride, is photolysed rapidly in sunlight and activates chlorine. Subsequent daytime oxidation via the chlorine atom can proceed orders of magnitude faster than that of the hydroxyl radical and therefore significantly perturb radical budgets and concentrations of ozone and secondary pollutants. Knowledge of the formation pathways, abundance and fate of these secondary pollutants, which can depend on ClNO2 abundance, is not fully understood but is necessary to support abatement strategies which will efficiently account for both primary and secondary pollutants. A Time of Flight Chemical Ionisation Mass Spectrometer (ToF CIMS) utilising the Filter Inlet for Gases and AEROsols (FIGAERO) was deployed in Changping, Beijing, during June and July, 2016 as part of an intercollaborative project to assess the photochemical smog in China. Concentrations of ClNO2 regularly exceeded 500 ppt throughout the campaign and reached a maximum concentration of 2.8 ppb, whereas relatively low N2O5 concentrations were observed, indicating a rapid heterogeneous production of ClNO2. Correlation of particulate chloride and carbon monoxide during the campaign suggests an anthropogenic chlorine source, also supported by high daytime Cl2 concentrations. Observations of ClNO2 desorptions using the FIGAERO suggest a possible unaccounted particulate reservoir of active chlorine in highly polluted regions. The persistence of ClNO2 several hours passed sunrise significantly increases the atomic chlorine production rate throughout the day further perturbing standard daytime oxidation processes. Simultaneous ToF CIMS measurements of Cl2, ClNO2, HCl, HOCl, OClO and ClONO2 were

  6. The CCCB is a cultural centre, not a tourist centre

    Directory of Open Access Journals (Sweden)

    Elena Xirau

    2004-04-01

    Full Text Available Last February, Barcelona's Centre of Contemporary Culture (CCCB celebrated its first ten years in existence. During this time, this institution has looked to be a showcase to the most modern and innovative cultural expressions focused on reflecting on the concept of the city. In this interview, Josep Ramoneda offers his personal view, as the CCCB's director. He talks of how this cultural project was born, of how the concept of the institution took shape in the CCCB, of its relations with Barcelona's Strategic Plan, of how the project has evolved, of the architectural remodelling of the Casa de la Caritat building for its conversion into a cultural centre, of the relations with other institutions and its future.

  7. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.

    Science.gov (United States)

    Romero-Camarero, Isabel; Jiang, Xiaoyu; Natkunam, Yasodha; Lu, Xiaoqing; Vicente-Dueñas, Carolina; Gonzalez-Herrero, Ines; Flores, Teresa; Garcia, Juan Luis; McNamara, George; Kunder, Christian; Zhao, Shuchun; Segura, Victor; Fontan, Lorena; Martínez-Climent, Jose A; García-Criado, Francisco Javier; Theis, Jason D; Dogan, Ahmet; Campos-Sánchez, Elena; Green, Michael R; Alizadeh, Ash A; Cobaleda, Cesar; Sánchez-García, Isidro; Lossos, Izidore S

    2013-01-01

    The human germinal centre-associated lymphoma gene is specifically expressed in germinal centre B-lymphocytes and germinal centre-derived B-cell lymphomas, but its function is largely unknown. Here we demonstrate that human germinal centre-associated lymphoma directly binds to Syk in B cells, increases its kinase activity on B-cell receptor stimulation and leads to enhanced activation of Syk downstream effectors. To further investigate these findings in vivo, human germinal centre-associated lymphoma transgenic mice were generated. Starting from 12 months of age these mice developed polyclonal B-cell lymphoid hyperplasia, hypergammaglobulinemia and systemic reactive amyloid A (AA) amyloidosis, leading to shortened survival. The lymphoid hyperplasia in the human germinal centre-associated lymphoma transgenic mice are likely attributable to enhanced B-cell receptor signalling as shown by increased Syk phosphorylation, ex vivo B-cell proliferation and increased RhoA activation. Overall, our study shows for the first time that the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B-cell lymphoproliferation.

  8. Deployment of a ground-based CIMS apparatus for the detection of organic gases in the boreal forest during the QUEST campaign

    Directory of Open Access Journals (Sweden)

    K. Sellegri

    2005-01-01

    Full Text Available Measurements of atmospheric volatile organic compounds were performed in the Finnish Boreal forest atmosphere during spring 2003, as part of the project QUEST (Quantification of Aerosol Nucleation in the European Boundary Layer, using a ground-based Chemical Ionization Mass Spectrometer (CIMS instrument. Based on the study of their hydrate distribution, methanol, acetonitrile, acetaldehyde, dimethyl amine (DMA, ethanol/formic acid, acetone, trimethyl amine (TMA, propanol/acetic acid, isoprene, methyl vinyl ketone (MVK and metacrolein (MaCR, monoterpenes and monoterpene oxidation product (MTOP are proposed as candidates for masses 32, 41, 44, 45, 46, 58, 59, 60, 68, 70, 136, and 168amu, respectively. It would be, to our knowledge, the first time DMA, TMA and MTOP are measured with this method. Most compounds show a clear diurnal variation with a maximum in the early night, corresponding to the onset of the noctural inversion and in agreement with independant measurements of CO. Biogenic compounds are highly correlated with each other and the ratio monoterpene/oxidation product shows a typical daily pattern of nightime maxima. However, because isoprene mixing ratios are also maximum during the early night, it is likely that it suffers of the interference from another unidentified biogenic compound. Hence mass 68amu is identified as isoprene+compound X.

  9. Deployment of a ground-based CIMS apparatus for the detection of organic gases in the boreal forest during the QUEST campaign

    Directory of Open Access Journals (Sweden)

    K. Sellegri

    2004-07-01

    Full Text Available Measurements of atmospheric volatile organic compounds were performed in the Finnish Boreal forest atmosphere during spring 2003, as part of the project QUEST (Quantification of Aerosol Nucleation in the European Boundary Layer, using a ground-based Chemical Ionization Mass Spectrometer (CIMS instrument. Based on the study of their hydrate distribution, Methanol, Acetonitrile, Acetaldehyde, Dimethyl Amine (DMA, Ethanol/Formic Acid, Acetone, Trimethyl Amine TMA, Propanol/Acetic Acid, Methyl Vinyl Ketone (MVK and Metacrolein (MaCR, Monoterpenes, Cis-3-hexenyl Acetate and Monoterpene Oxidation Products (MTOP are proposed as candidates for masses 33, 41, 44, 45, 46, 58, 59, 60, 70, 136, 142 and 168 amu, respectively. It would be, to our knowledge, the first time DMA, TMA, MTOP and Cis-3-hexenyl Acetate are measured with this method. A compound with mass 68 amu, which could be Isoprene has also been identified. Most compounds show a clear diurnal variation with higher concentrations at night, starting at the onset of the nocturnal inversion and in agreement with independent measurements of CO. Biogenic compounds are highly correlated with each other and the ratio monoterpene/oxidation product shows a typical daily pattern of nighttime maxima. Cis-3-hexenyl Acetate has a diurnal variation similar to the ones of Isoprene and Monoterpenes, and especially close to the diurnal variation of their oxidation products.

  10. Recovery of active anti TNF-α ScFv through matrix-assisted refolding of bacterial inclusion bodies using CIM monolithic support.

    Science.gov (United States)

    Sushma, Krishnan; Bilgimol, Chuvappumkal Joseph; Vijayalakshmi, Mookambeswaran A; Satheeshkumar, Padikara Kutty

    2012-04-01

    Anti TNF-α molecules are important as therapeutic agents for many of the autoimmune diseases in chronic stage. Here we report the expression and purification of a recombinant single chain variable fragment (ScFv) specific to TNF-α from inclusion bodies. In contrast to the conventional on column refolding using the soft gel supports, an efficient methodology using monolithic matrix has been employed. Nickel (II) coupled to convective interaction media (CIM) support was utilized for this purpose with 6M guanidine hydrochloride (GuHCl) as the chaotropic agent. The protein purified after solubilization and refolding proved to be biologically active with an IC₅₀ value of 15 μg. To the best of our knowledge, this is the first report showing the application of methacrylate based chromatographic supports for matrix-assisted refolding and purification of Escherichia coli inclusion bodies. The results are promising to elaborate the methodology further to exploit the potential positive features of monoliths in protein refolding science.

  11. WISB: Warwick Integrative Synthetic Biology Centre.

    Science.gov (United States)

    McCarthy, John

    2016-06-15

    Synthetic biology promises to create high-impact solutions to challenges in the areas of biotechnology, human/animal health, the environment, energy, materials and food security. Equally, synthetic biologists create tools and strategies that have the potential to help us answer important fundamental questions in biology. Warwick Integrative Synthetic Biology (WISB) pursues both of these mutually complementary 'build to apply' and 'build to understand' approaches. This is reflected in our research structure, in which a core theme on predictive biosystems engineering develops underpinning understanding as well as next-generation experimental/theoretical tools, and these are then incorporated into three applied themes in which we engineer biosynthetic pathways, microbial communities and microbial effector systems in plants. WISB takes a comprehensive approach to training, education and outreach. For example, WISB is a partner in the EPSRC/BBSRC-funded U.K. Doctoral Training Centre in synthetic biology, we have developed a new undergraduate module in the subject, and we have established five WISB Research Career Development Fellowships to support young group leaders. Research in Ethical, Legal and Societal Aspects (ELSA) of synthetic biology is embedded in our centre activities. WISB has been highly proactive in building an international research and training network that includes partners in Barcelona, Boston, Copenhagen, Madrid, Marburg, São Paulo, Tartu and Valencia.

  12. A high-resolution time-of-flight chemical ionization mass spectrometer utilizing hydronium ions (H3O+ ToF-CIMS) for measurements of volatile organic compounds in the atmosphere

    Science.gov (United States)

    Yuan, Bin; Koss, Abigail; Warneke, Carsten; Gilman, Jessica B.; Lerner, Brian M.; Stark, Harald; de Gouw, Joost A.

    2016-07-01

    Proton transfer reactions between hydronium ions (H3O+) and volatile organic compounds (VOCs) provide a fast and highly sensitive technique for VOC measurements, leading to extensive use of proton-transfer-reaction mass spectrometry (PTR-MS) in atmospheric research. Based on the same ionization approach, we describe the development of a high-resolution time-of-flight chemical ionization mass spectrometer (ToF-CIMS) utilizing H3O+ as the reagent ion. The new H3O+ ToF-CIMS has sensitivities of 100-1000 cps ppb-1 (ion counts per second per part-per-billion mixing ratio of VOC) and detection limits of 20-600 ppt at 3σ for a 1 s integration time for simultaneous measurements of many VOC species of atmospheric relevance. The ToF analyzer with mass resolution (m/Δm) of up to 6000 allows the separation of isobaric masses, as shown in previous studies using similar ToF-MS. While radio frequency (RF)-only quadrupole ion guides provide better overall ion transmission than ion lens system, low-mass cutoff of RF-only quadrupole causes H3O+ ions to be transmitted less efficiently than heavier masses, which leads to unusual humidity dependence of reagent ions and difficulty obtaining a humidity-independent parameter for normalization. The humidity dependence of the instrument was characterized for various VOC species and the behaviors for different species can be explained by compound-specific properties that affect the ion chemistry (e.g., proton affinity and dipole moment). The new H3O+ ToF-CIMS was successfully deployed on the NOAA WP-3D research aircraft for the SONGNEX campaign in spring of 2015. The measured mixing ratios of several aromatics from the H3O+ ToF-CIMS agreed within ±10 % with independent gas chromatography measurements from whole air samples. Initial results from the SONGNEX measurements demonstrate that the H3O+ ToF-CIMS data set will be valuable for the identification and characterization of emissions from various sources, investigation of secondary

  13. Potential for the speciation of Zn using fast protein liquid chromatography (FPLC) and convective interaction media (CIM) fast monolithic chromatography with FAAS and electrospray (ES)-MS-MS detection.

    Science.gov (United States)

    Svete, P; Milacic, R; Mitrovic, B; Pihlar, B

    2001-08-01

    Analytical procedures were developed for the speciation of Zn using fast protein liquid chromatography (FPLC), flame atomic absorption spectrometry (FAAS) and convective interaction media (CIM) fast monolithic chromatography with FAAS and electrospray (ES)-MS-MS detection. The investigation was performed on synthetic solutions (2 microg cm-3 Zn) of hydrated Zn2+ species and Zn complexes with citrate, oxalate and EDTA (ligand-to-Zn molar ratio 100:1) over a pH range from 5.4 to 7.4. It was found that Zn interacts with various buffers and the careful adjustment of the pH with diluted solutions of KOH is, therefore, required. FPLC separations were carried out on a Mono Q HR 5/5 strong anion-exchange column, applying an aqueous 1 mol dm(-3) NH4NO3 linear gradient elution over 15 min, at a flow rate of 1.0 cm3 min(-1). The separated Zn species were determined in 1.0 cm3 eluate fractions "off line" by FAAS. Speciation of Zn was also performed on a weak anion-exchange CIM DEAE fast monolithic disc by applying an aqueous 0.4 mol dm(-3) NH4NO3 linear gradient elution over 7.5 min, at a flow rate of 2.0 cm3 min(-1) and determination of the separated Zn species in 1.0 cm3 eluate fractions "off line" by FAAS. Zn-binding ligands in separated fractions were also characterized by electrospray (ES)-MS-MS analysis. The CIM DEAE disc was found to be more efficient in the separation of negatively charged Zn complexes than the Mono Q FPLC column. On the CIM DEAE disc Zn-citrate was separated from both Zn-oxalate and from Zn-EDTA. All these species were also separated from hydrated Zn2+, which was eluted with the solvent front. This method has an advantage over commonly used analytical techniques for the speciation of Zn which are only able to distinguish between labile and strong Zn complexes. Good repeatability of the measurements (RSD 2-4%), tested for six parallel determinations (2 microg cm(-3) Zn) of Zn-EDTA, Zn-citrate and Zn-oxalate was found at a pH of 6.4 on a CIM DAEA disc

  14. European Centre for Disease Prevention and Control.

    Science.gov (United States)

    Evans, Roger

    2014-11-04

    The European Centre for Disease Prevention and Control was set up in 2005 to strengthen Europe's defences against infectious diseases. The centre is an independent agency of the European Union and is based in Stockholm, Sweden.

  15. LABORATORY SERVICES IN HEALTH CENTRES WITHIN ...

    African Journals Online (AJOL)

    1999-05-05

    May 5, 1999 ... the technicians aimed at improving the services in health centres within ... Settings: Twenty seven health centres in Amhara region, north .... man power in the laboratory .... service consumption in a teaching hospital in Gondar,.

  16. Communicating astronomy by the Unizul Science Centre

    Science.gov (United States)

    Beesham, A.; Beesham, N.

    2015-03-01

    The University of Zululand, situated along the east coast of KwaZulu-Natal, has a thriving Science Centre (USC) situated in the developing port city of Richards Bay. Over 30 000 learners visit the centre annually, and it consists of an exhibition area, an auditorium, lecture areas and offices. The shows consist of interactive games, science shows, competitions, quizzes and matriculation workshops. Outreach activities take place through a mobile science centre for schools and communities that cannot visit the centre.

  17. Small Steps towards Student-Centred Learning

    Science.gov (United States)

    Jacobs, George M.; Toh-Heng, Hwee Leng

    2013-01-01

    Student centred learning classroom practices are contrasted with those in teacher centred learning classrooms. The discussion focuses on the theoretical underpinnings of the former, and provides nine steps and tips on how to implement student centred learning strategies, with the aim of developing the 21st century skills of self-directed and…

  18. Frequency selectivity at very low centre frequencies

    DEFF Research Database (Denmark)

    Orellana, Carlos Andrés Jurado; Pedersen, Christian Sejer; Marquardt, Torsten

    2010-01-01

    A significant factor in the decrease of sensitivity to low-frequency sound is the helicotrema shunt effect. In humans, it causes a slope increase of the middle-ear transfer function (METF) from 6 dB/oct to 12 dB/oct below approximately 50 Hz [Marquardt et al., J.Acoust. Soc. Am. 121, 3628......-3638 (2007)]. Recent experiments showed that the exact frequency varies from individual to individual. Besides, the helicotrema region in the METF has been found to highly influence frequency selectivity for centre frequencies (CFs) below 80 Hz (Jurado and Moore in prep). By using individual METF...... in the shape of the METFs, thought to be affected by the helicotrema impedance. Preliminary analysis indicates that individual differences in the METFs might underlay the observed individual differences in frequency selectivity. Main effects predicted by the calculations are a pronounced flattening off...

  19. Medical data transmission system for remote healthcare centres

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, E A; Cagnolo, F J; Olmos, C E; Centeno, C A; Riva, G G; Zerbini, C A [Clinical Engineering Group, National Technological University, Cordoba Regional Faculty, Maestro M Lopez St and Cruz Roja Argentina St, Cordoba (Argentina)

    2007-11-15

    The main motivation of this project is to improve the healthcare centres equipment and human resources efficiency, enabling those centres for transmission of parameters of medical interest. This system facilitates remote consultation, in particular between specialists and remote healthcare centres. Likewise it contributes to the qualification of professionals. The electrocardiographic (ECG) and electroencephalographic (EEG) signals are acquired, processed and then sent, fulfilling the effective norms, for application in the hospital network of Cordoba Province, which has nodes interconnected by phone line. As innovative aspects we emphasized the low cost of development and maintenance, great versatility and handling simplicity with a modular design for interconnection with diverse data transmission media (Wi-Fi, GPRS, etc.). Successfully experiences were obtained during the acquisition of the signals and transmissions on wired LAN networks. As improvements, we can mention: energy consumption optimization and mobile communication systems usage, in order to offer more autonomy.

  20. Student-Centred and Teacher-Centred Learning Environments: What Students Think

    Science.gov (United States)

    Elen, Jan; Clarebout, Geraldine; Leonard, Rebecca; Lowyck, Joost

    2007-01-01

    This contribution explores the relationship between teacher-centred and student-centred learning environments from a student's perspective. Three different views with respect to this relationship can be retrieved. The "balance" view suggests that the more teacher-centred a learning environment is, the less student-centred it is and vice versa. The…

  1. Powering the Future Data Centre

    DEFF Research Database (Denmark)

    Zhang, Zhe

    2010-01-01

    The extended run Uninterruptible Power Supply system (UPSs) which powered by fuel cells and supercapcitors, is a promising solution for future data centre to obtain environmentfriendly energy efficient and cost effective. There are many challenges in power electronic interface circuits, because...... of the traditional cascaded converters, a novel hybrid bidirectional dcdc converter which combines a fuel cell with a boost-type half bridge converter, and supercaps with a DAB converter, is proposed. With phase-shift plus duty cycle, all the switches realize ZVS in a wide range of load variation. Duty cycle control...

  2. Neighbourhood Centres – Organisation, Management and Finance

    DEFF Research Database (Denmark)

    Larsen, Jacob Norvig

    public subsidy. Some of the centres have high number of users on a daily basis, whereas others are only rarely used. It is explored how organisation, management and financial set-up differs among the centres. Quantitative data on financial issues and annual accounts of fifteen centres were analysed......From the late 1990s neighbourhood centres were brought to the fore of public urban regen-eration policy, because they were seen as a means to accelerate the formation of social capital in deprived urban neighbourhoods. A number of such local community centres were established with substantial...... to identify different financial models and analyse economic sustainability. As regards organisational and management models data were collected through documentary sources and by means of personal interviews and field visits to ten centres. Even within the analysed limited population of centres economic...

  3. Measurement of Organic Acids Produced By The Gas-Phase Ozonolysis of Simple Olefins Using Chemical Ionization Mass Spectrometry (CIMS) as a Function of Temperature And Humidity

    Science.gov (United States)

    Percival, C. J.; Bacak, A.; Leather, K. E.; McGillen, M. R.

    2009-12-01

    Non-methane hydrocarbons (NMHCs) form an important trace component of the atmosphere and are of particular environmental interest because of their deleterious effects on air quality, their numerous (and potentially counteractive) effects on Earth’s climate system and their sophisticated semiochemical roles in the world’s ecosystems. NMHCs are also important precursors to the formation of secondary organic aerosol (SOA) (e.g. Pandis et al., 1991; Kavouras et al., 1999). The ozonolysis reactions of olefins result in complex menageries of products, of which the acids are ubiquitous. Although the gas phase acid concentrations are small, they are thought to be key species in SOA formation as a result of their low volatility (e.g., Ma et al., 2009). Despite this, the factors that control acid formation are not well understood, especially with regards to humidity and temperature. Acid yields will be measured using the newly commissioned EXTreme RAnge (EXTRA) chamber (Leather et al., 2009). EXTRA is a 125 L stainless steel chamber, which can be temperature controlled using a commercial chest freezer unit (for T ≤ -20 °C) or a purpose built oven for T > 25 °C. The EXTRA chamber can be operated at pressures from 10-3800 Torr and at temperatures from 180-473 K. The stainless steel chamber walls have been coated with PFA to minimize wall loss of radicals. Fans, located at both ends of the cylinder, promote rapid mixing of reactants. Six sample ports are located at either end of the chamber for connection to ADS-GC-ECD, CIMS and commercial sensors such as a Thermo Electron Corporation 49i Ozone Analyzer, an Edinburgh Instruments Gascard CO2 sensor and a Trace Analytical inc. RGA3 CO analyzer. Experiments will be performed as a function of atmospherically relevant temperatures (T= 180-300 K). The field CIMS has sub ppt(v) L.O.D.s with a sub 1 Hz time response so will enable products to be quantified at very low concentrations in real time. Acid products will be detected

  4. Perceptual centres in speech - an acoustic analysis

    Science.gov (United States)

    Scott, Sophie Kerttu

    Perceptual centres, or P-centres, represent the perceptual moments of occurrence of acoustic signals - the 'beat' of a sound. P-centres underlie the perception and production of rhythm in perceptually regular speech sequences. P-centres have been modelled both in speech and non speech (music) domains. The three aims of this thesis were toatest out current P-centre models to determine which best accounted for the experimental data bto identify a candidate parameter to map P-centres onto (a local approach) as opposed to the previous global models which rely upon the whole signal to determine the P-centre the final aim was to develop a model of P-centre location which could be applied to speech and non speech signals. The first aim was investigated by a series of experiments in which a) speech from different speakers was investigated to determine whether different models could account for variation between speakers b) whether rendering the amplitude time plot of a speech signal affects the P-centre of the signal c) whether increasing the amplitude at the offset of a speech signal alters P-centres in the production and perception of speech. The second aim was carried out by a) manipulating the rise time of different speech signals to determine whether the P-centre was affected, and whether the type of speech sound ramped affected the P-centre shift b) manipulating the rise time and decay time of a synthetic vowel to determine whether the onset alteration was had more affect on P-centre than the offset manipulation c) and whether the duration of a vowel affected the P-centre, if other attributes (amplitude, spectral contents) were held constant. The third aim - modelling P-centres - was based on these results. The Frequency dependent Amplitude Increase Model of P-centre location (FAIM) was developed using a modelling protocol, the APU GammaTone Filterbank and the speech from different speakers. The P-centres of the stimuli corpus were highly predicted by attributes of

  5. The new AMS control centre

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    Construction work for the future AMS control room began in November 2010 and should be finished this June. The new building, which will have been completed in record time thanks to the professionalism of the project team, will soon be ready to receive the initial data from the AMS experiment.     Luigi Scibile and Michael Poehler, from the GS department, at the AMS control centre construction site.   The Alpha Magnetic Spectrometer (AMS) is due to wing its way towards the International Space Station (ISS) on board the shuttle Discovery in April. Mainly intended for research on antimatter and dark matter, the data collected by AMS will be sent to Houston in the United States and then directly to CERN’s new Building 946. Construction work for the AMS control centre building on the Route Gentner at CERN’s Prévessin site started in November 2010 and must be completed in time to receive the first data from the spectrometer in June. “It normall...

  6. Powering the Future Data Centre

    DEFF Research Database (Denmark)

    Zhang, Zhe

    2010-01-01

    The extended run Uninterruptible Power Supply system (UPSs) which powered by fuel cells and supercapcitors, is a promising solution for future data centre to obtain environmentfriendly energy efficient and cost effective. There are many challenges in power electronic interface circuits, because...... of the characteristics of these two power sources: long warm-up stage and low dynamics for fuel cell, and variable terminal voltage for supercapacitors. The motivation for this project was to find ways which can overcome those limitations to integrate fuel cells and supercapcitors to the system with high efficiency...... and high reliability. Therefore, special focus is given to hybrid dc conversion circuits. From an overview of current state-of-the-art, based on the work of others, the thesis will show the methods utilized in this project to combining fuel cells and supercapcitors for the frontend dc system with cascaded...

  7. A situated-Information Motivation Behavioral Skills Model of Care Initiation and Maintenance (sIMB-CIM): an IMB model based approach to understanding and intervening in engagement in care for chronic medical conditions.

    Science.gov (United States)

    Rivet Amico, K

    2011-10-01

    A sizable portion of adults living with chronic medical conditions (CMCs) delay initiation of care or maintain it inconsistently, which has tremendous personal and public costs. However, few explanatory models with high yield for intervention development and implementation have been proposed to date that would help to characterize and support care use for CMCs. A situated Information, Motivation, Behavioral Skills model of Care Initiation and Maintenance (sIMB-CIM) is presented here as an application of the IMB model to medical care use for CMCs. An example of a sIMB model for characterizing and intervening to support maintenance in HIV-care is provided.

  8. Activities of Radiation Protection Centre in 2000

    CERN Document Server

    Radiat. Prot. Cent. Vilnius

    2001-01-01

    Description of the activities of Radiation Protection Centre in 2000 is presented. Radiation Protection Centre is responsible for radiation protection issues. Currently there are six departments at Radiation Protection Centre: two in Vilnius - Department of Radiation Protection Supervision and Control and Department of Programs and Expertise, and four in the districts. Brief information on subject controlled by each departments is provided focusing on main achievements and events.

  9. Criteria of Categorizing Logistics and Distribution Centres

    OpenAIRE

    Darko Babić; Anđelko Šćukanec; Kristijan Rogic

    2011-01-01

    Logistics and distribution centres represent very significant infrastructure elements of the macro-logistic system. The creation of the logistics and distribution centres and their connection into a wide (global) network have resulted in the creation of conditions for an adequate distribution of labour and significant increase in the productivity of all the logistics elements and processes, noting that the logistics and distribution centres in this concept have a superregional significance. ...

  10. Smart work centres in rural areas

    DEFF Research Database (Denmark)

    Lorentzen, Anne Birte

    This paper discusses the establishment of telework centres as an element in local development strategies in rural areas, with a particular view to two new telework centres in region North Denmark. The paper argues that telework centres do not represent an easy solution to problems of local develo...... development and environmental sustainability, and further, that technology may not even be the most important feature needed to make them function as such....

  11. Criteria of Categorizing Logistics and Distribution Centres

    Directory of Open Access Journals (Sweden)

    Darko Babić

    2011-07-01

    Full Text Available Logistics and distribution centres represent very significant infrastructure elements of the macro-logistic system. The creation of the logistics and distribution centres and their connection into a wide (global network have resulted in the creation of conditions for an adequate distribution of labour and significant increase in the productivity of all the logistics elements and processes, noting that the logistics and distribution centres in this concept have a superregional significance. This paper represents the summary (results of the research that was carried out on a large number of logistics and distribution centres with the aim of considering the complexity and the issues related to the logistics and distribution centres and the distribution network, their elements and action of the subsystems according to the following criteria: spatial, technical, technological, and organizational, with the aim of defining the categorisation model of the logistics and distribution centres. The analysis of the selected data collected during the research has resulted in defining of the categorisation model of the logistics and distribution centres which foresees six categories. Each of the foreseen categories has been defined according to the set model by the mentioned traffic, technical and technological, and organisational characteristics and the level of service. This is precisely where the application of the categorisation model of the logistics and distribution centres can be found, which will define the relevant categories of the centres applicable in the creation of effective distribution

  12. Performance Appraisal-Management by Objective and Assessment Centre

    Directory of Open Access Journals (Sweden)

    Kai-Ping Huang

    2011-01-01

    Full Text Available Problem statement: Two methods for performance appraisal that are discussed in this study and they are Management By Objective (MBO and Assessment Centre techniques. Employees are appraised for several reasons, the most important of which is to realize the best use of human resources and to plan for future needs; reward and punishment are secondary. Assessment Centre evaluation or appraisal is valuable because it allows a candidate to concentrate on the task at hand. Approach: The literature review and arguments were conducted to provide a systematic discussion of the study. Results: In Management by Objective performance appraisal, employees are obliged to deal with overcoming empirical challenges. In Assessment Centre Appraisal, the different outcomes for particular tasks can be evaluated and management can assess employees relative proficiencies in terms of these tasks. In both forms, consistency in criteria is crucial, for purposes of comparison and standardization. Where comparisons are made with other employees, the criteria need to be parallel for employees at similar levels of responsibility. Conclusion: Differences between organizational cultures will impact on the way that assessment results are received under MBO performance appraisal as well. The outcomes that employees achieve in the tasks provided for appraisal purposes may involve different levels of risk, even within firm guidelines. In the assessment centre, the candidate is separated from colleagues. To make comparative rating assessments, effective MBO will incorporate objective criteria. At times, MBO will be useful in judging change over time for employees performing fairly routine work.

  13. Semicontinuous measurements of gas-particle partitioning of organic acids in a ponderosa pine forest using a MOVI-HRToF-CIMS

    Science.gov (United States)

    Yatavelli, R. L. N.; Stark, H.; Thompson, S. L.; Kimmel, J. R.; Cubison, M. J.; Day, D. A.; Campuzano-Jost, P.; Palm, B. B.; Hodzic, A.; Thornton, J. A.; Jayne, J. T.; Worsnop, D. R.; Jimenez, J. L.

    2014-02-01

    Hundreds of gas- and particle-phase organic acids were measured in a rural ponderosa pine forest in Colorado, USA, during BEACHON-RoMBAS (Bio-hydro-atmosphere interactions of Energy, Aerosols, Carbon, H2O, Organics & Nitrogen - Rocky Mountain Biogenic Aerosol Study). A recently developed micro-orifice volatilization impactor high-resolution time-of-flight chemical ionization mass spectrometer (MOVI-HRToF-CIMS) using acetate (CH3C(O)O-) as the reagent ion was used to selectively ionize and detect acids semicontinuously from 20 to 30 August 2011, with a measurement time resolution of ~1.5 h. At this site 98% of the organic acid mass is estimated to be in the gas phase, with only ~2% in the particle phase. We investigated gas-particle partitioning, quantified as the fraction in the particle phase (Fp), of C1-C18 alkanoic acids, six known terpenoic acids, and bulk organic acids vs. carbon number. Data were compared to the absorptive partitioning model and suggest that bulk organic acids at this site follow absorptive partitioning to the organic aerosol mass. The rapid response (<1-2 h) of partitioning to temperature changes for bulk acids suggests that kinetic limitations to equilibrium are minor, which is in contrast to conclusions of some recent laboratory and field studies, possibly due to lack of very low ambient relative humidities at this site. Time trends for partitioning of individual and groups of acids were mostly captured by the model, with varying degrees of absolute agreement. Species with predicted substantial fractions in both the gas and particle phases show better absolute agreement, while species with very low predicted fractions in one phase often show poor agreement, potentially due to thermal decomposition, inlet adsorption, or other issues. Partitioning to the aqueous phase is predicted to be smaller than to the organic phase for alkanoic and bulk acids, and has different trends with time and carbon number than observed experimentally. This is due

  14. Semi-continuous measurements of gas/particle partitioning of organic acids in a ponderosa pine forest using a MOVI-HRToF-CIMS

    Science.gov (United States)

    Yatavelli, R. L. N.; Stark, H.; Thompson, S. L.; Kimmel, J. R.; Cubison, M. J.; Day, D. A.; Campuzano-Jost, P.; Palm, B. B.; Thornton, J. A.; Jayne, J. T.; Worsnop, D. R.; Jimenez, J. L.

    2013-06-01

    Hundreds of gas and particle phase organic acids were measured in a rural ponderosa pine forest in Colorado, USA, during the Bio-hydro-atmosphere interactions of Energy, Aerosols, Carbon, H2O, Organics and Nitrogen - Rocky Mountain Biogenic Aerosol Study (BEACHON-RoMBAS). A recently developed Micro-Orifice Volatilization Impactor High-Resolution Time-of-Flight Chemical Ionization Mass Spectrometer (MOVI-HRToF-CIMS) using acetate (CH3C(O)O-) as the reagent ion was used to selectively ionize and detect acids semi-continuously from 20-30 August 2011, with a measurement time resolution of ~1.5 h. At this site 98% of the organic acid mass is estimated to be in the gas-phase, with only ~2% in the particle phase. We investigated gas/particle partitioning, quantified as the fraction in the particle phase (Fp), of C1-C18 alkanoic acids, six known terpenoic acids and total bulk organic acids. Data were compared to the absorptive partitioning model and suggest that bulk organic acids at this site follow absorptive partitioning to the organic aerosol mass. The rapid response (<1-2 h) of partitioning to temperature changes for bulk acids suggests that kinetic limitations to equilibrium are minor, which is in contrast to conclusions of some recent laboratory and field studies, possibly due to lack of very low ambient relative humidities at this site. Time trends for partitioning of individual and groups of acids were mostly captured by the model, with varying degrees of absolute agreement. Species with predicted substantial fractions in both the gas and particle phases show better absolute agreement, while species with very low predicted fractions in one phase often show agreement on trends, but poor absolute agreement, potentially due to thermal decomposition, inlet adsorption, or other issues. Based on measurement-model comparison we conclude that species carbon number and oxygen content, together with ambient temperature control the volatility of organic acids and are good

  15. Semi-continuous measurements of gas/particle partitioning of organic acids in a ponderosa pine forest using a MOVI-HRToF-CIMS

    Directory of Open Access Journals (Sweden)

    R. L. N. Yatavelli

    2013-06-01

    Full Text Available Hundreds of gas and particle phase organic acids were measured in a rural ponderosa pine forest in Colorado, USA, during the Bio-hydro-atmosphere interactions of Energy, Aerosols, Carbon, H2O, Organics and Nitrogen – Rocky Mountain Biogenic Aerosol Study (BEACHON-RoMBAS. A recently developed Micro-Orifice Volatilization Impactor High-Resolution Time-of-Flight Chemical Ionization Mass Spectrometer (MOVI-HRToF-CIMS using acetate (CH3C(OO- as the reagent ion was used to selectively ionize and detect acids semi-continuously from 20–30 August 2011, with a measurement time resolution of ~1.5 h. At this site 98% of the organic acid mass is estimated to be in the gas-phase, with only ~2% in the particle phase. We investigated gas/particle partitioning, quantified as the fraction in the particle phase (Fp, of C1–C18 alkanoic acids, six known terpenoic acids and total bulk organic acids. Data were compared to the absorptive partitioning model and suggest that bulk organic acids at this site follow absorptive partitioning to the organic aerosol mass. The rapid response (<1–2 h of partitioning to temperature changes for bulk acids suggests that kinetic limitations to equilibrium are minor, which is in contrast to conclusions of some recent laboratory and field studies, possibly due to lack of very low ambient relative humidities at this site. Time trends for partitioning of individual and groups of acids were mostly captured by the model, with varying degrees of absolute agreement. Species with predicted substantial fractions in both the gas and particle phases show better absolute agreement, while species with very low predicted fractions in one phase often show agreement on trends, but poor absolute agreement, potentially due to thermal decomposition, inlet adsorption, or other issues. Based on measurement-model comparison we conclude that species carbon number and oxygen content, together with ambient temperature control the volatility of organic

  16. CIM - A Manufacturing Paradigm (Le CIM - Un Nouveau Modele Industriel),

    Science.gov (United States)

    1986-07-01

    fait la plupart des entreprises , ont affind le module de "Rgvolution industrielle". Nous vivons A l’poque du spdcialiste. Toutefois, le modale de sp...program will serve as an umbrella under which specific projects are planned, financed , managed, and imple- mented. Well defined corporate goals must be...assets. Through an integration of financing strategies an enterprise can focus on capital investment in shared, value-added assets such as databases

  17. Capturing Reality at Centre Block

    Science.gov (United States)

    Boulanger, C.; Ouimet, C.; Yeomans, N.

    2017-08-01

    The Centre Block of Canada's Parliament buildings, National Historic Site of Canada is set to undergo a major rehabilitation project that will take approximately 10 years to complete. In preparation for this work, Heritage Conservation Services (HCS) of Public Services and Procurement Canada has been completing heritage documentation of the entire site which includes laser scanning of all interior rooms and accessible confined spaces such as attics and other similar areas. Other documentation completed includes detailed photogrammetric documentation of rooms and areas of high heritage value. Some of these high heritage value spaces present certain challenges such as accessibility due to the height and the size of the spaces. Another challenge is the poor lighting conditions, requiring the use of flash or strobe lighting to either compliment or completely eliminate the available ambient lighting. All the spaces captured at this higher level of detail were also captured with laser scanning. This allowed the team to validate the information and conduct a quality review of the photogrammetric data. As a result of this exercise, the team realized that in most, if not all cases, the photogrammetric data was more detailed and at a higher quality then the terrestrial laser scanning data. The purpose and motivation of this paper is to present these findings, as well provide the advantages and disadvantages of the two methods and data sets.

  18. CAPTURING REALITY AT CENTRE BLOCK

    Directory of Open Access Journals (Sweden)

    C. Boulanger

    2017-08-01

    Full Text Available The Centre Block of Canada’s Parliament buildings, National Historic Site of Canada is set to undergo a major rehabilitation project that will take approximately 10 years to complete. In preparation for this work, Heritage Conservation Services (HCS of Public Services and Procurement Canada has been completing heritage documentation of the entire site which includes laser scanning of all interior rooms and accessible confined spaces such as attics and other similar areas. Other documentation completed includes detailed photogrammetric documentation of rooms and areas of high heritage value. Some of these high heritage value spaces present certain challenges such as accessibility due to the height and the size of the spaces. Another challenge is the poor lighting conditions, requiring the use of flash or strobe lighting to either compliment or completely eliminate the available ambient lighting. All the spaces captured at this higher level of detail were also captured with laser scanning. This allowed the team to validate the information and conduct a quality review of the photogrammetric data. As a result of this exercise, the team realized that in most, if not all cases, the photogrammetric data was more detailed and at a higher quality then the terrestrial laser scanning data. The purpose and motivation of this paper is to present these findings, as well provide the advantages and disadvantages of the two methods and data sets.

  19. Laparoscopic adrenalectomy: Single centre experience.

    LENUS (Irish Health Repository)

    O'Farrell, N J

    2012-02-01

    BACKGROUND: Laparoscopic adrenalectomy is an attractive alternative to the traditional open approach in the surgical excision of an adrenal gland. It has replaced open adrenalectomy in our institution and we review our experience to date. METHODS: All cases of laparoscopic adrenalectomies in our hospital over eight years (from 2001 to May 2009) were retrospectively reviewed. Patient demographics, diagnosis, length of hospital stay, histology and all operative and post-operative details were evaluated. RESULTS: Fifty-five laparoscopic adrenalectomies (LA) were performed on 51 patients over eight years. The mean age was 48 years (Range 16-86 years) with the male: female ratio 1:2. Twenty-three cases had a right adrenalectomy, 24 had a left adrenalectomy and the remaining four patients had bilateral adrenalectomies. 91% were successfully completed laparoscopically with five converted to an open approach. Adenomas (functional and non functional) were the leading indication for LA, followed by phaeochromocytomas. Other indications for LA included Cushing\\'s disease, adrenal malignancies and rarer pathologies. There was one mortality from necrotising pancreatitis following a left adrenalectomy for severe Cushing\\'s disease, with subsequent death 10 days later. CONCLUSION: Laparoscopic adrenalectomy is effective for the treatment of adrenal tumours, fulfilling the criteria for the ideal minimally invasive procedure. It has replaced the traditional open approach in our centre and is a safe and effective alternative. However, in the case of severe Cushing\\'s disease, laparoscopic adrenalectomy has the potential for significant adverse outcomes and mortality.

  20. Primary investigation on course reformation thought of higher vocational management information system based on enterprise CIMS%基于企业CIMS的高职管理信息系统课改思路初探

    Institute of Scientific and Technical Information of China (English)

    宋洁

    2014-01-01

    此文针对高职院校《管理信息系统》课程教学的现状,探讨在教学内容上如何引入企业CIMS的相关内容,使学生了解企业CIMS环境下的管理信息系统如何开发,对于教学工作以及学生今后的学习和工作都具有重要的实用价值和广阔的应用前景。%Based on the current situation of “Management Information System”course teaching in high vocational colleges ,this paper discusses how to introduce the enterprise CIMS related contents into the teaching contents so as to enable the students to understand how to develop the management informa-tion system in enterprise CIMS environment ,which has important practical value and wide application prospect for the teaching job and the future study and working of students .

  1. 基于物联网技术的输变电设备模型的研究%Research and Application of Power Transmission and Transformation Equipment Based on CIM Model and Internet of Thing

    Institute of Scientific and Technical Information of China (English)

    黄炜

    2016-01-01

    输变电设备CIM模型构建是输变电物联网关键技术实施的基础,关系着设备智能管理与其他高级应用的数据交互与共享、业务的变更与增加。本文研究了IEC 61850和基于IEC 61970的CIM模型特点及使用范围,对两种模型统一与映射方法进行了探讨。%Power transmission and transformation equipment CIM model building is a key technology to implement the basis of power transmission and transformation of things, the relationship between the equipment of intelligent management and other advanced applications, business change and increase interaction and sharing data After studied IEC 61850 and IEC 61970 series standard based on IEC 61850 and IEC 61970 CIM model characteristics and use scope, the uniifed two models and mapping methods are discussed in this paper.

  2. Oil Trading Centre to Reopen in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Chinese oil companies will likely resume activities at the oil trading centre in Shanghai this year, a move to further liberalize the once tightly controlled oil market. The centre will trade forward contracts for refined oil products,including gasoline, diesel oil, kerosene and fuel oil, industrial sources said.

  3. Student-Centred Learning (SCL): Roles Changed?

    Science.gov (United States)

    Onurkan Aliusta, Gülen; Özer, Bekir

    2017-01-01

    This paper addresses the espoused and enacted practices of high school teachers with regard to student-centred learning (SCL). Explanatory mixed-method design, where quantitative strand is followed by qualitative one, is employed. While the quantitative strand aims to explore teachers' perceptions regarding the extent student-centred teacher and…

  4. Neighbourhood Centres – Organisation, Management and Finance

    DEFF Research Database (Denmark)

    Larsen, Jacob Norvig

    From the late 1990s neighbourhood centres were brought to the fore of public urban regen-eration policy, because they were seen as a means to accelerate the formation of social capital in deprived urban neighbourhoods. A number of such local community centres were established with substantial pub...

  5. Student Centred Approaches: Teachers' Learning and Practice

    Science.gov (United States)

    Vale, Colleen; Davies, Anne; Weaven, Mary; Hooley, Neil

    2010-01-01

    Student centred approaches to teaching and learning in mathematics is one of the reforms currently being advocated and implemented to improve mathematics outcomes for students from low socio-economic status (SES) backgrounds. The models, meanings and practices of student centred approaches explored in this paper reveal that a constructivist model…

  6. The Press Research Centre, 1956-1976.

    Science.gov (United States)

    Press Research Centre, Krakow (Poland).

    In 1956, the Press Research Centre was established in Cracow, Poland by a group of journalists and publishers, for the purpose of instituting press research that would have practical applications. The aims of the Centre were to conduct studies on the history of the Polish press, the contemporary press, press readership, and editorial techniques.…

  7. The role of the sexual assault centre.

    LENUS (Irish Health Repository)

    Eogan, Maeve

    2013-02-01

    Sexual Assault Centres provide multidisciplinary care for men and women who have experienced sexual crime. These centres enable provision of medical, forensic, psychological support and follow-up care, even if patients chose not to report the incident to the police service. Sexual Support Centres need to provide a ring-fenced, forensically clean environment. They need to be appropriately staffed and available 24 hours a day, 7 days a week to allow prompt provision of medical and supportive care and collection of forensic evidence. Sexual Assault Centres work best within the context of a core agreed model of care, which includes defined multi-agency guidelines and care pathways, close links with forensic science and police services, and designated and sustainable funding arrangements. Additionally, Sexual Assault Centres also participate in patient, staff and community education and risk reduction. Furthermore, they contribute to the development, evaluation and implementation of national strategies on domestic, sexual and gender-based violence.

  8. Centre for urban ecotechnology in ``Oeksnehallen``

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    The Lord Mayor`s Department of the municipality of Copenhagen, Denmark, has with support from this project made a proposal for the establishment of the Centre for Urban Ecotechnology in ``Oeksnehallen``, located in the Vesterbro area of the city. The centre should contribute to the dissemination of knowledge on ecological techniques (regarding passive solar energy etc.) to the inhabitants of Vesterbro and other citizens of Copenhagen, and also serve as a centre in an European context. The ecological demonstration centre will cover an area of two thousand square meters and will also include a cafe, a room for showing coloured slides, facilities for exhibitions created by the center and interested firms etc. The centre should play an important role as part of the ecological concept of urban renewal in Vesterbro. (author).

  9. The Charles Perkins Centre's Twins Research Node.

    Science.gov (United States)

    Ferreira, Lucas C; Craig, Jeffrey M; Hopper, John L; Carrick, Susan E

    2016-08-01

    Twins can help researchers disentangle the roles of genes from those of the environment on human traits, health, and diseases. To realize this potential, the Australian Twin Registry (ATR), University of Melbourne, and the Charles Perkins Centre (CPC), University of Sydney, established a collaboration to form the Twins Research Node, a highly interconnected research facility dedicated specifically to research involving twins. This collaboration aims to foster the adoption of twin designs as important tools for research in a range of health-related domains. The CPC hosted their Twins Research Node's launch seminar entitled 'Double the power of your research with twin studies', in which experienced twin researchers described how twin studies are supporting scientific discoveries and careers. The launch also featured twin pairs who have actively participated in research through the ATR. Researchers at the CPC were surveyed before the event to gauge their level of understanding and interest in utilizing twin research. This article describes the new Twins Research Node, discusses the survey's main results and reports on the launch seminar.

  10. Effect of Road Traffic Noise Pollution on Human Work Efficiency in Government Offices, Private Organizations, and Commercial Business Centres in Agartala City Using Fuzzy Expert System: A Case Study

    Directory of Open Access Journals (Sweden)

    Debasish Pal

    2012-01-01

    Full Text Available This study examines the problems of reduction of individual’s efficiency in his/her respective working places because of road traffic noise pollution in Agartala due to rapidly growing vehicular traffic. This paper deals with monitoring and modeling of the disturbances caused due to vehicular road traffic interrupted by traffic flow conditions on personal work performance. Total of two hundred seventy individuals from different road side Government Offices, Private Organizations and Commercial Business Centres on both sides of busy roads of the city were interviewed for attitudinal responses. Traffic volume count and noise indices data were collected simultaneously at six selected sites of the city. A relationship was developed between different traffic noise parameters and its harmful impact on work competency of individuals using MATLAB. Regression equations developed to predict the percentage of high annoyance among the individuals are fit based on noise parameters and parameters related to traffic movements. In addition, statistical analysis was also carried out between measured and predictive values of the percentage of highly annoyed group of individuals. The present model will draw the attention of the State Government and will help the policy maker to take the necessary steps to reduce this problem.

  11. PET Centre and Centre for Functionally Integrative Neuroscience, Aarhus University

    DEFF Research Database (Denmark)

    Cumming, Paul; Pedersen, Mads Damgaard; Minuzzi, Luciano

    2006-01-01

    The cerebral distribution of peripheral-type benzodiazepine binding sites (PBBS) in human brain has been investigated by positron emission tomography (PET) with the specific radioligand [11C]PK11195 in diverse neuropathological conditions. However, little is known about the pattern of PK11195 bin...

  12. Big Surveys, Big Data Centres

    Science.gov (United States)

    Schade, D.

    2016-06-01

    Well-designed astronomical surveys are powerful and have consistently been keystones of scientific progress. The Byurakan Surveys using a Schmidt telescope with an objective prism produced a list of about 3000 UV-excess Markarian galaxies but these objects have stimulated an enormous amount of further study and appear in over 16,000 publications. The CFHT Legacy Surveys used a wide-field imager to cover thousands of square degrees and those surveys are mentioned in over 1100 publications since 2002. Both ground and space-based astronomy have been increasing their investments in survey work. Survey instrumentation strives toward fair samples and large sky coverage and therefore strives to produce massive datasets. Thus we are faced with the "big data" problem in astronomy. Survey datasets require specialized approaches to data management. Big data places additional challenging requirements for data management. If the term "big data" is defined as data collections that are too large to move then there are profound implications for the infrastructure that supports big data science. The current model of data centres is obsolete. In the era of big data the central problem is how to create architectures that effectively manage the relationship between data collections, networks, processing capabilities, and software, given the science requirements of the projects that need to be executed. A stand alone data silo cannot support big data science. I'll describe the current efforts of the Canadian community to deal with this situation and our successes and failures. I'll talk about how we are planning in the next decade to try to create a workable and adaptable solution to support big data science.

  13. Holistic design : learning from the Learning Centre

    Energy Technology Data Exchange (ETDEWEB)

    Simon, C. [Charles Simon Architect and Planner, Eden Mills, ON, (Canada); McKee, C. [Kitchener-Waterloo YMCA Outdoor Services, ON (Canada)

    2004-08-01

    The energy efficiency of several solar technologies currently in operation at the Kitchener-Waterloo YMCA's Environmental Learning Centre was evaluated. The off-grid earth-sheltered building dug into a south-facing slope features a sod roof, and protection from north winds by coniferous tree plantations. Passive solar strategies are evaluated, including average indoor temperatures and lighting requirements in both summer and winter. Also evaluated were the centre's ventilation systems, windows and passive heat recovery ventilators (HRVs), solar collectors, masonry heaters, and photovoltaic panels. The centre's composting toilets and use of the Living Machine{sup TM} were also discussed and details of the centre's building materials were provided. Ten straw-bale cabins are currently under construction at the centre, using passive solar strategies for heating, ventilation and cooling and combination propane fired/solar hot water heaters, straw bale building envelope and wood frame roof. Further suggestions for the centre's potential uses, and an outline of the centre's ongoing priorities were outlined. 4 refs.

  14. New centre for intelligent mining systems

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, W.

    2002-10-01

    A Centre for Intelligent Mining Systems has been opened by the University of Alberta's Computing Science Department, a collaborative effort by the University and Syncrude Canada Ltd. The objective of the new Centre is to apply technologies in the area of artificial intelligence and robotics to the problems of surface mining. The Centre has already attracted attention from other players within the industry and a long-term funding proposal by a consortium that includes Syncrude is in the works. Noranda Inc and Inco Inc have also shown interest.

  15. Modelling total energy costs of sports centres

    Energy Technology Data Exchange (ETDEWEB)

    Boussabaine, A.H.; Kirkham, R.J.; Grew, R.J. [Liverpool Univ., School of Architecture and Building Engineering, Liverpool (United Kingdom)

    1999-12-07

    Providing and maintaining safe and comfortable conditions in sport centres raises many issues, particularly cost. The paper gives an overview of the factors associated with sport centre servicing and attempts to highlight the governing factors associated with this, particularly energy costs. A total of 19 sport centres in the City of Liverpool in the UK are investigated, using data elicited from the Liverpool Leisure Services Directorate. The energy operating costs were analysed using statistical methods. Six models were developed to predict total energy costs. Testing and validation results showed a high level of model accuracy. The models would be of use to professionals involved in feasibility studies at the design stage. (Author)

  16. Review of CERN Data Centre Infrastructure

    CERN Document Server

    Andrade, P; van Eldik, J; McCance, G; Panzer-Steindel, B; Coelho dos Santos, M; Traylen, S; Schwickerath, U

    2012-01-01

    The CERN Data Centre is reviewing strategies for optimizing the use of the existing infrastructure and expanding to a new data centre by studying how other large sites are being operated. Over the past six months, CERN has been investigating modern and widely-used tools and procedures used for virtualisation, clouds and fabric management in order to reduce operational effort, increase agility and support unattended remote data centres. This paper gives the details on the project’s motivations, current status and areas for future investigation.

  17. Planetary Radars Operating Centre PROC

    Science.gov (United States)

    Catallo, C.; Flamini, E.; Seu, R.; Alberti, G.

    2007-12-01

    Planetary exploration by means of radar systems, mainly using Ground Penetrating Radars (GPR) plays an important role in Italy. Numerous scientific international space programs are currently carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Three important experiments under Italian leadership ( designed and manufactured by the Italian industry), provided by ASI either as contribution to ESA programs either within a NASA/ASI joint venture framework, are now operating: MARSIS on-board Mars Express, SHARAD on-board Mars Reconnaissance Orbiter and CASSINI Radar on-board Cassini spacecraft. In order to support all the scientific communities, institutional customers and experiment teams operation three Italian dedicated operational centers have been realized, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD ( Processing Altimetry Data). Each center is dedicated to a single instrument management and control, data processing and distribution. Although they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). PROC is conceived in order to include the three operational centers, namely SHOC, MOC and CASSINI PAD, either from logistics point of view and from HW/SW capabilities point of view. The Planetary Radar Processing Center shall be conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs. Therefore, scalability, easy use and management shall be the design drivers. The paper describes how PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. Furthermore, in the frame of

  18. Symmetric centres of braided monoidal categories

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper introduces the concept of‘symmetric centres' of braided monoidal categories. Let H be a Hopf algebra with bijective antipode over a field k. We address the symmetric centre of the Yetter-Drinfel'd module category HH(yD) and show that a left Yetter-Drinfel'd module M belongs to the symmetric centre of HH(yD) if and only if M is trivial. We also study the symmetric centres of categories of representations of quasitriangular Hopf algebras and give a sufficient and necessary condition for the braid of H(M) to induce the braid of (H(H)(A),(○)A,A,φ,l,r), or equivalently, the braid of (A#H(H),(○)A,A,φ,l,r), where A is a quantum commutative H-module algebra.

  19. Potential of Natural Ventilation in Shopping Centres

    DEFF Research Database (Denmark)

    Diederichsen, Alice; Friis, Kristina; Brohus, Henrik

    2008-01-01

    The indoor environmental quality (IEQ) is a fundamental requirement for a well performing shopping centre. This paper contains a pilot study of the potential of using hybrid ventilation (a combination of automatically controlled natural and mechanical ventilation - respectively NV and MV) in shop......The indoor environmental quality (IEQ) is a fundamental requirement for a well performing shopping centre. This paper contains a pilot study of the potential of using hybrid ventilation (a combination of automatically controlled natural and mechanical ventilation - respectively NV and MV......) in shopping centres with focus on both the achieved IEQ and energy consumptions for air movement. By thermal building simulations it is found that there exists an interesting potential for hybrid ventilation of shopping centres, which can lead to great savings in the electrical energy consumptions...

  20. Identity Theft: A Study in Contact Centres

    Science.gov (United States)

    Moir, Iain; Weir, George R. S.

    This paper explores the recent phenomenon of identity theft. In particular, it examines the contact centre environment as a mechanism for this to occur. Through a survey that was conducted amongst forty-five contact centre workers in the Glasgow area we determined that contact centres can and do provide a mechanism for identity theft. Specifically, we found a particularly high incidence of agents who had previously dealt with phone calls that they considered suspicious. Furthermore, there are agents within such environments who have previously been offered money in exchange for customers' details, or who know of fellow workers who received such offers. Lastly, we identify specific practices within contact centres that may contribute to the likelihood of identity theft.

  1. Social innovation for People-Centred Development

    DEFF Research Database (Denmark)

    Hulgård, Lars; P.K., Shajahan

    2013-01-01

    Social innovation is closely related to the people-centred development (PCD) framework of knowledge production. The discussion of PCD in this chapter particularly expands on the feature of empowerment and socio-political mobilization of people in social innovation......Social innovation is closely related to the people-centred development (PCD) framework of knowledge production. The discussion of PCD in this chapter particularly expands on the feature of empowerment and socio-political mobilization of people in social innovation...

  2. Perspectives on recycling centres and future developments.

    Science.gov (United States)

    Engkvist, I-L; Eklund, J; Krook, J; Björkman, M; Sundin, E

    2016-11-01

    The overall aim of this paper is to draw combined, all-embracing conclusions based on a long-term multidisciplinary research programme on recycling centres in Sweden, focussing on working conditions, environment and system performance. A second aim is to give recommendations for their development of new and existing recycling centres and to discuss implications for the future design and organisation. Several opportunities for improvement of recycling centres were identified, such as design, layout, ease with which users could sort their waste, the work environment, conflicting needs and goals within the industry, and industrialisation. Combining all results from the research, which consisted of different disciplinary aspects, made it possible to analyse and elucidate their interrelations. Waste sorting quality was recognized as the most prominent improvement field in the recycling centre system. The research identified the importance of involving stakeholders with different perspectives when planning a recycling centre in order to get functionality and high performance. Practical proposals of how to plan and build recycling centres are given in a detailed checklist.

  3. The Imperial College Thermophysical Properties Data Centre

    Science.gov (United States)

    Angus, S.; Cole, W. A.; Craven, R.; de Reuck, K. M.; Trengove, R. D.; Wakeham, W. A.

    1986-07-01

    The IUPAC Thermodynamic Tables Project Centre in London has at its disposal considerable expertise on the production and utilization of high-accuracy equations of state which represent the thermodynamic properties of substances. For some years they have been content to propagate this information by the traditional method of book production, but the increasing use of the computer in industry for process design has shown that an additional method was needed. The setting up of the IUPAC Transport Properties Project Centre, also at Imperial College, whose products would also be in demand by industry, afforded the occasion for a new look at the problem. The solution has been to set up the Imperial College Thermophysical Properties Data Centre, which embraces the two IUPAC Project Centres, and for it to establish a link with the existing Physical Properties Data Service of the Institution of Chemical Engineers, thus providing for the dissemination of the available information without involving the Centres in problems such as those of marketing and advertising. This paper outlines the activities of the Centres and discusses the problems in bringing their products to the attention of industry in suitable form.

  4. A Technique of Automatic Generation of Substation Wiring Diagram Based on CIM%一种基于CIM的厂站接线图自动生成技术

    Institute of Scientific and Technical Information of China (English)

    沙树名; 林峰

    2008-01-01

    以典型接线形式的图形排布为依据,提出了一种根据设备连接信息自动生成接线图的经验方法,即通过可扩展的典型接线形式的定义,借助于Oracle Spatial的网络分析功能,对公共信息模型(CIM)数据中有关厂站内的设备及连接关系的部分进行分析和匹配,按照匹配到的接线形式排布厂站内各设备的位置,从而自动生成接线图.

  5. Methods Of Testing And Assessing The Technical Condition Of Chosen Building Structures Located In The Area Of The Auschwitz-Birkenau National Museum In Oświęcim

    Directory of Open Access Journals (Sweden)

    Kańka Stanisław

    2015-12-01

    Full Text Available The results presented in this article consider the means of assessing the technical condition of two selected buildings, i.e. prisoner barracks number 123 and 124, located at the Auschwitz-Birkenau State Museum in Oświęcim. The work was carried out within the framework of a research project involving the development of methods for preserving, securing and strengthening the structure of buildings, along with their substrate and finishes. The aim of the project was to gain a knowledge base reflecting the actual state of the existing facilities and, on that basis, develop preservation methods and ways to protect the existing facilities against further damage, while maintaining the current character.

  6. EFSA (European Food Safety Authority) and ECDC (European Centre for Disease Prevention and Control), 2015. EU Summary Report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2013

    DEFF Research Database (Denmark)

    Korsgaard, Helle Bisgaard

    of isolates were resistant to ciprofloxacin and tetracyclines, while resistance to erythromycin was low to moderate. The resistance to fluoroquinolones in some MSs was extremely high; in such settings, the effective treatment option for human enteric Campylobacter infection may be significantly reduced. High...... to extremely high resistance to ciprofloxacin, nalidixic acid and tetracyclines was observed in Campylobacter isolates from fowl, broiler meat, pigs and cattle, whereas much lower levels were observed for erythromycin and gentamicin. Increasing trends in ciprofloxacin resistance were observed in Campylobacter...... to ciprofloxacin....

  7. Decentred Centre in John Fowles’s The Magus

    Directory of Open Access Journals (Sweden)

    Aleks Matosoğlu

    2015-12-01

    Full Text Available Decentred Centre in John Fowles’sThe Magus Abstract John Fowles’ The Magus (1966 has been the focus of criticism for many years. This study regards the character of Conchis as a decentred “centre” in the structure of the novel and as in the experience of the contemporary humanity. Conchis becomes in the eyes of Nicholas an all-knowing figure, an accumulation of Western thought since the Greek civilization. He produces signs to be read as he himself becomes a body of various signs that construct him as the metaphysical centre that Western thinkers have relied upon. His narration becomes superior to Nicholas’ and he himself becomes only a narrative voice. The voice from the times of Plato has been considered as a direct expression of the thoughts in one’s mind and thus superior to writing that is permeated with the undecidability of meaning in the absence of the speaker and the addressee. In the novel, words as an endless play of metaphors take the place of voice. There is no knowable reality outside the play words or metaphors which is an endless chain of signifiers that lead to other signifiers. Every time Nicholas turns to Conchis to find the centre outside the play of the language, he finds other signifiers. Thus, Conchis as a meaning-making centre is dethroned. He is not the sole operator of the masks that divert from their presumed original target when they are read. Nicholas is just another production of the literary tradition who reads the signs only to produce other signs. Conchis in the beginning of the novel renounces fiction for science but along the course of the novel, we see that words are never reliable whether in fiction or in science.

  8. Transmission of HIV in dialysis centre.

    Science.gov (United States)

    Velandia, M; Fridkin, S K; Cárdenas, V; Boshell, J; Ramirez, G; Bland, L; Iglesias, A; Jarvis, W

    1995-06-01

    In August, 1993, 13 dialysis patients at one dialysis centre in Colombia, South America, were found to be HIV positive, and this prompted an epidemiological investigation. We carried out a cohort study of all dialysis centre patients during January, 1992 to December, 1993 (epidemic period) to determine risk factors for HIV seroconversion. Haemodialysis and medical records were reviewed, dialysis centre staff and surviving patients were interviewed, and dialysis practices were observed. Stored sera from all dialysis centre patients were tested for HIV antibody. 12 (52%) of 23 patients tested positive for HIV antibody by enzyme immunoassay and western blot during the epidemic period. Of the 23 tested, 9 (39%) converted from HIV antibody negative to positive (seroconverters) and 10 (44%) remained HIV negative (seronegatives). The HIV seroconversion rate was higher among patients dialysed at the centre while a new patient, who was HIV seropositive, was dialysed there (90% vs 0%; p dialysis centre reprocessed access needles, dialysers, and bloodlines (60% vs 0%). While 2 of 9 HIV seroconverters had had sex with prostitutes, none had received unscreened blood products or had other HIV risk factors. No surgical or dental procedures were associated with HIV seroconversion. Dialysers were reprocessed separately with 5% formaldehyde and were labelled for use on the same patient. Access needles were reprocessed by soaking them in a common container with a low-level disinfectant, benzalkonium chloride; 4 pairs of needles were placed in one pan creating the potential for cross-contamination or use of one patient's needles on another patient. HIV transmission at the dialysis centre was confirmed. Improperly reprocessed patient-care equipment, most probably access needles, is the likely mechanism of transmission. This outbreak was discovered by accident and similar transmission may be occurring in many other countries where low-level disinfectants are used to sterilise critical

  9. Visits to Tier-1 Computing Centres

    CERN Multimedia

    Dario Barberis

    At the beginning of 2007 it became clear that an enhanced level of communication is needed between the ATLAS computing organisation and the Tier-1 centres. Most usual meetings are ATLAS-centric and cannot address the issues of each Tier-1; therefore we decided to organise a series of visits to the Tier-1 centres and focus on site issues. For us, ATLAS computing management, it is most useful to realize how each Tier-1 centre is organised, and its relation to the associated Tier-2s; indeed their presence at these visits is also very useful. We hope it is also useful for sites... at least, we are told so! The usual participation includes, from the ATLAS side: computing management, operations, data placement, resources, accounting and database deployment coordinators; and from the Tier-1 side: computer centre management, system managers, Grid infrastructure people, network, storage and database experts, local ATLAS liaison people and representatives of the associated Tier-2s. Visiting Tier-1 centres (1-4). ...

  10. Scavenger hunt in the CERN Computing Centre

    CERN Multimedia

    CERN Bulletin

    2013-01-01

    Hidden among the racks of servers and disks in the CERN Computing Centre, you’ll find Hawaiian dancers, space aliens, gorillas… all LEGO® figurines! These characters were placed about the Centre for the arrival of Google’s Street View team for the world to discover.   PLEASE NOTE THAT THE COMPETITION IS OVER. ONLY FOR REFERENCE, HERE IS THE ORIGINAL ARTICLE. We’re pleased to announce our first global scavenger hunt! Spot three LEGO® figurines using Google’s Street View and you’ll be entered to win a gift of your choice from our CERN Gift Guide. A LEGO® figurine in the CERN Computing Centre, as seen on Google Street View. Here are the details: Find at least three LEGO® figurines hidden around the CERN Computing Centre using Google Street View.   Take screencaps of the figurines and e-mail the pictures to TreasureHunt-ComputingCentre@cern.ch. This email is no longer active.   The...

  11. The Aube centre. 1997 statement; Le centre de l`Aube. Bilan 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    Since January 1992 the Aube centre ensures the storage of 90% of the short life radioactive wastes produced in France. This educational booklet describes the organization of the activities in the centre from the storage of wastes to the radioactivity surveillance of the environment (air, surface and ground waters, river sediments, plants and milk). (J.S.)

  12. A day in the CERN Control Centre

    CERN Multimedia

    Rosaria Marraffino

    2015-01-01

    The CERN Control Centre (CCC) is the nerve centre of the CERN beam systems. From this room, the experts prepare, monitor, adjust, and control the particle beams that circulate throughout the accelerator complex while ensuring that the services and the technical infrastructure work flawlessly. Buttons, screens, telephones, lights (but no sound): in the CCC, everything is ready to make it possible for the LHC to reach the unprecedented energies expected at Run 2.   Seen from above, the CERN Control Centre resembles the shape of a quadrupole magnet. The consoles are distributed in four circles, called “islands”, dedicated to the LHC, the SPS, the PS Complex and the Technical Infrastructure (TI) respectively. Spread between TI and LHC are the Cryogenics consoles. Being in the same room allows the 24h-manned islands to be constantly in touch with one another, thus ensuring the best performance of the machines. At the LHC island, operators are currently busy training the magnet...

  13. Information Centre Radioactivity Switzerland; Beratungsstelle Radioaktivitaet Schweiz

    Energy Technology Data Exchange (ETDEWEB)

    Mosimann, N.; Balsiger, B.; Burger, M. [Bundesamt fuer Bevoelkerungsschutz (Switzerland). LABOR SPIEZ

    2016-07-01

    The Information Centre Radioactivity Switzerland is meant to assess the radiological condition and serves for psychological-medical care of affected members of the Swiss public following an event of increased radioactivity in the environment. The Centre is structured in a modular way consisting of the following modules: ''Entry Measurement'': The visitors are registered and measured for contamination, ''Decontamination'': Contaminated visitors are decontaminated, ''Additional Measurements'': If required, thyroid and whole body measurements are performed, ''Information'': The visitors are informed about radioactivity, radiation protection, the current situation and their individual next steps, ''Exit'': Administrative release from the Information Centre.

  14. Occupational deprivation in an asylum centre:

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin

    2013-01-01

    This article presents a study of three asylum-seeking men from Iran and Afghanistan. It aimed to explore how and if they experienced occupations as occupations in a Danish asylum centre and how their life experience shaped their choice and value of current occupations. In-depth narrative interviews...... explored the participants’ occupational history and its influence on their occupations in the asylum centre. A thematic analysis showed that the participants had been subjected to occupational disruption and deprivation by politically oppressive systems even before their flight. Their occupations...... in Denmark were to a certain extent influenced by their earlier occupations and the current occupational deprivation they all experienced was due to limited possibilities in the centre. Although they tried their best to fill their days and create structure, there was a loss of valued occupations...

  15. Learning Styles of Independent Learning Centre Users

    Directory of Open Access Journals (Sweden)

    Tarik Uzun

    2014-09-01

    Full Text Available Learning style research has been a significant field within language teaching and learning. There have been very few attempts, however, to seek possible links between independent learning and learning style preferences. This paper aims to identify the learning styles of students who use the Independent Learning Centre (ILC on a regular basis at a state university in Turkey (n=102. The findings of the learning style analysis revealed that, contrary to expectations, most of the regular users of the centre were synoptic learners, which implies that these learners might not necessarily have conscious control over their own learning processes. An in-depth analysis of learning styles and recommendations to improve the services offered in the centre are also included in the paper.

  16. Optimizing Data Centre Energy and Environmental Costs

    Science.gov (United States)

    Aikema, David Hendrik

    Data centres use an estimated 2% of US electrical power which accounts for much of their total cost of ownership. This consumption continues to grow, further straining power grids attempting to integrate more renewable energy. This dissertation focuses on assessing and reducing data centre environmental and financial costs. Emissions of projects undertaken to lower the data centre environmental footprints can be assessed and the emission reduction projects compared using an ISO-14064-2-compliant greenhouse gas reduction protocol outlined herein. I was closely involved with the development of the protocol. Full lifecycle analysis and verifying that projects exceed business-as-usual expectations are addressed, and a test project is described. Consuming power when it is low cost or when renewable energy is available can be used to reduce the financial and environmental costs of computing. Adaptation based on the power price showed 10--50% potential savings in typical cases, and local renewable energy use could be increased by 10--80%. Allowing a fraction of high-priority tasks to proceed unimpeded still allows significant savings. Power grid operators use mechanisms called ancillary services to address variation and system failures, paying organizations to alter power consumption on request. By bidding to offer these services, data centres may be able to lower their energy costs while reducing their environmental impact. If providing contingency reserves which require only infrequent action, savings of up to 12% were seen in simulations. Greater power cost savings are possible for those ceding more control to the power grid operator. Coordinating multiple data centres adds overhead, and altering at which data centre requests are processed based on changes in the financial or environmental costs of power is likely to increase this overhead. Tests of virtual machine migrations showed that in some cases there was no visible increase in power use while in others power use

  17. THE ELUSIVENESS OF LEARNER-CENTRED TEACHING

    Directory of Open Access Journals (Sweden)

    Ervin Kovačević

    2016-03-01

    Full Text Available This research will explore teaching styles of university professors. Teaching style is an umbrella term for teaching decisions made during the entire teaching process – planning, delivery, and evaluation. Contemporary university teachers are advised to adopt the learner-centred teaching style which is assumed to produce remarkable possibilities. In the Fall Semester 2015 fifty-two respondents in different faculties of International University of Sarajevo were surveyed using The Principles of Adult Learning Scale inventory designed by Gary J. Conti. Inventory scores were calculated according to guidelines suggested by the author of the inventory. The scores revealed that majority of respondents strongly supported teacher-centred rather than learner-centred styles of instruction. Scores were analysed on gender lines and across three different faculties, namely: Arts and Social Sciences; Business and Administration; Engineering and Natural Sciences. In all five groups none of the seven teaching style indicators was found to conform with the learner-centred teaching criteria. There was no statistically significant difference between the two genders’ preference for a teaching style. And there was no statistically significant difference between teaching style preference across the three different faculties.The results of this research imply that the learner-centred style of instruction is not frequently implemented. Secondly, the results indicate that the requirements necessary for proper application of the learner-centred teaching style are not easy to meet in current written and unwritten norms. Finally, the results show that traditional teaching styles, which have been preserved in different scientific fields, still predominate in universities.

  18. Byurakan Astrophysical Observatory as Cultural Centre

    Science.gov (United States)

    Mickaelian, A. M.; Farmanyan, S. V.

    2016-12-01

    NAS RA V. Ambartsumian Byurakan Astrophysical Observatory is presented as a cultural centre for Armenia and the Armenian nation in general. Besides being scientific and educational centre, the Observatory is famous for its unique architectural ensemble, rich botanical garden and world of birds, as well as it is one of the most frequently visited sightseeing of Armenia. In recent years, the Observatory has also taken the initiative of the coordination of the Cultural Astronomy in Armenia and in this field, unites the astronomers, historians, archaeologists, ethnographers, culturologists, literary critics, linguists, art historians and other experts.

  19. Byurakan Astrophysical Observatory as Cultural Centre

    Science.gov (United States)

    Mickaelian, A. M.; Farmanyan, S. V.

    2017-07-01

    NAS RA V. Ambartsumian Byurakan Astrophysical Observatory is presented as a cultural centre for Armenia and the Armenian nation in general. Besides being scientific and educational centre, the Observatory is famous for its unique architectural ensemble, rich botanical garden and world of birds, as well as it is one of the most frequently visited sightseeing of Armenia. In recent years, the Observatory has also taken the initiative of the coordination of the Cultural Astronomy in Armenia and in this field, unites the astronomers, historians, archaeologists, ethnographers, culturologists, literary critics, linguists, art historians and other experts. Keywords: Byurakan Astrophysical Observatory, architecture, botanic garden, tourism, Cultural Astronomy.

  20. Enhancing person-centred communication in NICU

    DEFF Research Database (Denmark)

    Weis, Janne; Zoffmann, Vibeke; Egerod, Ingrid

    2015-01-01

    Aims of this article were (a) to explore how parents of premature infants experience guided family-centred care (GFCC), and (b) to compare how parents receiving GFCC versus standard care (SC) describe nurse-parent communication in the neonatal intensive care unit.......Aims of this article were (a) to explore how parents of premature infants experience guided family-centred care (GFCC), and (b) to compare how parents receiving GFCC versus standard care (SC) describe nurse-parent communication in the neonatal intensive care unit....

  1. [Accreditation criteria and quality standards for Poisons centres: development of a quality management system within the Milan Poisons centre].

    Science.gov (United States)

    Della Puppa, Tiziana; Manfrè, Sergio; Grezzi, Marinella

    2006-01-01

    Poisons centres throughout Italy and Europe vary considerably in terms of their institutions and organisation. The European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) has laid down the activities that a poisons centre must carry out, specifying minimum and maximum standards required. These directions allow an evaluation of the service provided. In 2002 Milan Poisons Centre began a project aiming to introduce concepts and methodology proper of the quality systems within poisons centres' institutional activity. Concluded, the project resulted in the centre's certification and the documentation of its procedures: this may now contribute to help define the status and activity of poisons centres in Italy.

  2. Flare forecasting at the Met Office Space Weather Operations Centre

    Science.gov (United States)

    Murray, S. A.; Bingham, S.; Sharpe, M.; Jackson, D. R.

    2017-04-01

    The Met Office Space Weather Operations Centre produces 24/7/365 space weather guidance, alerts, and forecasts to a wide range of government and commercial end-users across the United Kingdom. Solar flare forecasts are one of its products, which are issued multiple times a day in two forms: forecasts for each active region on the solar disk over the next 24 h and full-disk forecasts for the next 4 days. Here the forecasting process is described in detail, as well as first verification of archived forecasts using methods commonly used in operational weather prediction. Real-time verification available for operational flare forecasting use is also described. The influence of human forecasters is highlighted, with human-edited forecasts outperforming original model results and forecasting skill decreasing over longer forecast lead times.

  3. [The coordination of care in health centres].

    Science.gov (United States)

    Ribardière, Olivia

    2016-06-01

    Health centres are structurally designed to facilitate the coordination of care. However, evolutions in society have resulted in forms of consumption of health care which are not necessarily compatible with efficient care coordination. On a local level, teams are nevertheless organising and structuring themselves to offer the right form of care, to the right patient and at the right time.

  4. Renovation of the CERN Computer Centre

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    The Computer Centre at CERN is seen after half of the equipment is the large ground floor room has been removed. A large-scale spring-cleaning operation took place before renovation work for the new CERN Grid system began. Fifteen kilometres of cables that were no longer needed were removed from the cavity floor for recycling.

  5. Visiting a science centre: what's on offer?

    Science.gov (United States)

    Russell, Ian

    1990-09-01

    Science centres are a valuable resource, used more frequently by family groups and primary school parties than by secondary schools. The importance of affective learning, involving attitude changes, is stressed. Provided the right approach is used, accompanying adults can help children get the most out of a visit.

  6. Centre de formació virtual

    OpenAIRE

    Mòdol Martínez, Oscar

    2012-01-01

    Treball de fi de carrera en .NET sobre un centre de formació virtual, desenvolupat en la plataforma .NET amb ASP.NET, VB.NET i Windows Phone 7. Trabajo de fin de carrera en .NET sobre un centro de formación virtual, desarrollado en la plataforma .NET con ASP.NET, VB.NET y Windows Phone 7.

  7. Self Assessment and Student-Centred Learning

    Science.gov (United States)

    McDonald, Betty

    2012-01-01

    This paper seeks to show how self assessment facilitates student-centred learning (SCL) and fills a gap in the literature. Two groups of students were selected from a single class in a tertiary educational institution. The control group of 25 was selected randomly by the tossing of an unbiased coin (heads = control group). They were trained in the…

  8. Student-Centred Learning: A Humanist Perspective

    Science.gov (United States)

    Tangney, Sue

    2014-01-01

    The notion of student-centred learning is often not defined; within the pedagogic literature it is generally associated with constructivism or principles associated with a constructivist environment such as building on prior knowledge, purposeful active learning and sense-making. An informal enquiry into conceptions of university staff prior to…

  9. Patient-centred tuberculosis treatment in Tanzania

    NARCIS (Netherlands)

    Mkopi, A.B.

    2015-01-01

    The main aim of this thesis was to describe and assess the efficacy of the Patient-Centred Treatment (PCT) strategy for the delivery and supervision of tuberculosis (TB) treatment as implemented by the National Tuberculosis and Leprosy programme of Tanzania. The studies presented in this thesis show

  10. Youth Research Centre Annual Report, 2002.

    Science.gov (United States)

    Melbourne Univ. (Australia). Youth Research Centre.

    This report details the activities of the Youth Research Centre (YRC) at the University of Melbourne in 2002 in research project work involving a balance between the completion of projects, the development of new areas, and the continuation of longer-term projects as well as the supervision and teaching of a range of postgraduate health and…

  11. Mandibular trauma: a two-centre study

    NARCIS (Netherlands)

    Boffano, P.; Kommers, S.C.; Karagozoglu, K.H.; Gallesio, C.; Forouzanfar, T.

    2015-01-01

    The aims of this study were to assess and compare epidemiological data on mandibular fractures from two European centres and to perform a review of the literature. Between 2001 and 2010, a total of 752 patients with a total of 1167 mandibular fractures were admitted to a hospital in Turin, and 245 p

  12. Regional Dermatology Training Centre in Moshi, Tanzania ...

    African Journals Online (AJOL)

    31 No. 7. Regional Dermatology Training Centre in Moshi, Tanzania – pursuing a dream ... little training in the management of skin disease.[1] ... through lack of trained personnel or resources ... With time, other facilities such as a library, a pharmaceutical compounding ... of information on dermatology and STIs in a tropical ...

  13. Flexible Processes in Project-Centred Learning

    NARCIS (Netherlands)

    Ceri, Stefano; Matera, Maristella; Raffio, Alessandro; Spoelstra, Howard

    2007-01-01

    Ceri, S., Matera, M., Raffio, A. & Spoelstra, H. (2007). Flexible Processes in Project-Centred Learning. In E. Duval, R. Klamma, and M. Wolpers (Eds.), European Conference on Technology Enhanced Learning, Lecture Notes in Computer Science, Vol. 4753, pp. 463-468. Berlin Heidelberg: Springer-Verlag

  14. Myanmar: The Community Learning Centre Experience.

    Science.gov (United States)

    Middelborg, Jorn; Duvieusart, Baudouin, Ed.

    A community learning centre (CLC) is a local educational institution outside the formal education system, usually set up and managed by local people. CLCs were first introduced in Myanmar in 1994, and by 2001 there were 71 CLCs in 11 townships. The townships are characterized by remoteness, landlessness, unemployment, dependency on one cash crop,…

  15. Cactus: The Centres of a Triangle

    Science.gov (United States)

    Hyde, Hartley

    2009-01-01

    This is the first of two articles which describe how to use "JavaSketchPad" to explore the centres of a triangle. This introductory exercise is suggested in the GSP "Workshop Guide". Students can use "JavaSketchPad Interactive Geometry" (JSP) at home at no cost. They are likely to impress their parents with their enthusiasm for geometry and all…

  16. The INTEGRAL science data centre (ISDC)

    DEFF Research Database (Denmark)

    Courvoisier, T.J.L.; Walter, Rasmus; Beckmann, V.

    2003-01-01

    The INTEGRAL Science Data Centre (ISDC) provides the INTEGRAL data and means to analyse them to the scientific community. The ISDC runs a gamma ray burst alert system that provides the position of gamma ray bursts on the sky within seconds to the community. It operates a quick-look analysis...

  17. Person-centred care in nursing documentation.

    LENUS (Irish Health Repository)

    Broderick, Margaret C

    2012-12-07

    BACKGROUND: Documentation is an essential part of nursing. It provides evidence that care has been carried out and contains important information to enhance the quality and continuity of care. Person-centred care (PCC) is an approach to care that is underpinned by mutual respect and the development of a therapeutic relationship between the patient and nurse. It is a core principle in standards for residential care settings for older people and is beneficial for both patients and staff (International Practice Development in Nursing and Healthcare, Chichester, Blackwell, 2008 and The Implementation of a Model of Person-Centred Practice in Older Person Settings, Dublin, Health Service Executive, 2010a). However, the literature suggests a lack of person-centredness within nursing documentation (International Journal of Older People Nursing 2, 2007, 263 and The Implementation of a Model of Person-Centred Practice in Older Person Settings, Dublin, Health Service Executive, 2010a). AIMS AND OBJECTIVES: To explore nursing documentation in long-term care, to determine whether it reflected a person-centred approach to care and to describe aspects of PCC as they appeared in nursing records. METHOD: A qualitative descriptive study using the PCN framework (Person-centred Nursing; Theory and Practice, Oxford, Wiley-Blackwell, 2010) as the context through which nursing assessments and care plans were explored. RESULTS: Findings indicated that many nursing records were incomplete, and information regarding psychosocial aspects of care was infrequent. There was evidence that nurses engaged with residents and worked with their beliefs and values. However, nursing documentation was not completed in consultation with the patient, and there was little to suggest that patients were involved in decisions relating to their care. IMPLICATIONS FOR PRACTICE: The structure of nursing documentation can be a major obstacle to the recording of PCC and appropriate care planning. Documentation

  18. Hardware design of the cortical-diencephalic centre of the lower urinary tract neuroregulator system.

    Science.gov (United States)

    Maciá-Pérez, Francisco; Zambrano-Mendez, Leandro; Berna-Martínez, José-Vicente; Sepúlveda-Lima, Roberto

    2016-10-01

    The neuroregulator system in humans controls organ and system functioning. This system comprises a set of neural centres that are distributed along the spinal cord and act independently together with their nerve interconnections. The centres involved in this task were isolated in previous studies through investigations of the functioning and composition of the neuroregulator system of the lower urinary tract to elucidate their individual performances and enable the creation of a general neuroregulator system model capable of operating at the neuronal level. Although the long-term goal of our research is the development of a system on chip (SoC) capable of behaving as a fully programmable neuroregulator system, this work is another step in which we test the viability of the hardware design of one of these neuroregulator centres (specifically the cortical-diencephalic centre) to achieve a first prototype and architectural proposal. To this end, the behaviour of this centre has been isolated, a hardware design implemented on FPGA has been proposed to create a prototype, a simulation environment has been built for the evaluation, and finally, the results have been analysed. This system verified that the functional behaviour corresponded to the expected behaviour in humans and that the operational requirements for the implementation were technically and architecturally viable.

  19. Histomorphological study of germinal centre of vermiform appendix in Bangladeshi cadaver.

    Science.gov (United States)

    Rahman, M M; Sultana, S Z; Mannan, S; Ara, Z G; Chowdhury, A I; Ara, A; Mukta, T B

    2013-01-01

    The study was done to find out the number of germinal centre in human vermiform appendix of Bangladeshi people to magnify the knowledge regarding the diverse number of germinal centre of human vermiform appendix in our population in the department of Anatomy, Mymensingh Medical College, Bangladesh from July 2006 to June 2007. Total 40 appendices were collected for histological study of different age and sex during postmortem examination in the autopsy laboratory of department of Forensic Medicine, Mymensingh Medical College. This cross sectional study was done by convenient sampling technique. For convenience of differentiating the changes in number of germinal centre of vermiform appendix in relation to age and sex, findings were classified in four groups, Group A up to 20 years, Group B 21-35 years, Group C 36-55 years and Group D 56-70 years. In the present study the number of germinal centre was highest in Group B (52.38%) but in Group D it was nil. Here mean number of germinal centre in male (1.05) were more than in female (0.8).

  20. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.

    Science.gov (United States)

    Muppidi, Jagan R; Schmitz, Roland; Green, Jesse A; Xiao, Wenming; Larsen, Adrien B; Braun, Sterling E; An, Jinping; Xu, Ying; Rosenwald, Andreas; Ott, German; Gascoyne, Randy D; Rimsza, Lisa M; Campo, Elias; Jaffe, Elaine S; Delabie, Jan; Smeland, Erlend B; Braziel, Rita M; Tubbs, Raymond R; Cook, J R; Weisenburger, Dennis D; Chan, Wing C; Vaidehi, Nagarajan; Staudt, Louis M; Cyster, Jason G

    2014-12-11

    Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet the signalling pathways that are deregulated and the factors leading to its systemic dissemination are poorly defined. Work in mice showed that sphingosine-1-phosphate receptor-2 (S1PR2), a Gα12 and Gα13 coupled receptor, promotes growth regulation and local confinement of germinal centre B cells. Recent deep sequencing studies of GCB-DLBCL have revealed mutations in many genes in this cancer, including in GNA13 (encoding Gα13) and S1PR2 (refs 5,6, 7). Here we show, using in vitro and in vivo assays, that GCB-DLBCL-associated mutations occurring in S1PR2 frequently disrupt the receptor's Akt and migration inhibitory functions. Gα13-deficient mouse germinal centre B cells and human GCB-DLBCL cells were unable to suppress pAkt and migration in response to S1P, and Gα13-deficient mice developed germinal centre B-cell-derived lymphoma. Germinal centre B cells, unlike most lymphocytes, are tightly confined in lymphoid organs and do not recirculate. Remarkably, deficiency in Gα13, but not S1PR2, led to germinal centre B-cell dissemination into lymph and blood. GCB-DLBCL cell lines frequently carried mutations in the Gα13 effector ARHGEF1, and Arhgef1 deficiency also led to germinal centre B-cell dissemination. The incomplete phenocopy of Gα13- and S1PR2 deficiency led us to discover that P2RY8, an orphan receptor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement via Gα13. These findings identify a Gα13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma.

  1. Mapping the Context and Practice of Training, Development and HRD in European Call Centres

    Science.gov (United States)

    Garavan, Thomas N.; Wilson, John P.; Cross, Christine; Carbery, Ronan

    2008-01-01

    Purpose: Utilising data from 18 in-depth case studies, this study seeks to explore training, development and human resource development (HRD) practices in European call centres. It aims to argue that the complexity and diversity of training, development and HRD practices is best understood by studying the multilayered contexts within which call…

  2. Mapping the Context and Practice of Training, Development and HRD in European Call Centres

    Science.gov (United States)

    Garavan, Thomas N.; Wilson, John P.; Cross, Christine; Carbery, Ronan

    2008-01-01

    Purpose: Utilising data from 18 in-depth case studies, this study seeks to explore training, development and human resource development (HRD) practices in European call centres. It aims to argue that the complexity and diversity of training, development and HRD practices is best understood by studying the multilayered contexts within which call…

  3. Measurement of Eccentricity of the Centre of Mass from the Geometric Centre of a Sphere

    Institute of Scientific and Technical Information of China (English)

    郭俊起; 胡忠坤; 顾邦明; 罗俊

    2004-01-01

    The eccentricity of the centre of mass from the geometric centre of a spherical attracting mass in determining the Newtonian gravitational constant G is tested by means of an electronic balance. The experimental result shows that the eccentricity of the sample is about 0.31 μm with uncertainty of 0.05 μm. Two density distribution models are discussed to estimate the uncertainty to G by the eccentricities of the attracting masses.

  4. HISTORIC CENTRE(S OF BARCELONA: PRACTICAL AND SYMBOLIC ELEMENTS IN TRADITIONAL URBAN SPACE

    Directory of Open Access Journals (Sweden)

    Verónica Martínez Robles

    2007-09-01

    The model of compact city that Barcelona aims, has required the renewal of its historical areas, and in order to improve their level of centrality, taking into account, that in addition of its historical centre “Ciutat Vella”, Barcelona contains diverse traditional neighborhoods each of them having their own historical centre. The difference centre‐periphery should also be perceived among these other historical centers. Integration should not be confused with standardization, neither differentiation with segregation.

  5. Effects of unstratified and centre-stratified randomization in multi-centre clinical trials.

    Science.gov (United States)

    Anisimov, Vladimir V

    2011-01-01

    This paper deals with the analysis of randomization effects in multi-centre clinical trials. The two randomization schemes most often used in clinical trials are considered: unstratified and centre-stratified block-permuted randomization. The prediction of the number of patients randomized to different treatment arms in different regions during the recruitment period accounting for the stochastic nature of the recruitment and effects of multiple centres is investigated. A new analytic approach using a Poisson-gamma patient recruitment model (patients arrive at different centres according to Poisson processes with rates sampled from a gamma distributed population) and its further extensions is proposed. Closed-form expressions for corresponding distributions of the predicted number of the patients randomized in different regions are derived. In the case of two treatments, the properties of the total imbalance in the number of patients on treatment arms caused by using centre-stratified randomization are investigated and for a large number of centres a normal approximation of imbalance is proved. The impact of imbalance on the power of the study is considered. It is shown that the loss of statistical power is practically negligible and can be compensated by a minor increase in sample size. The influence of patient dropout is also investigated. The impact of randomization on predicted drug supply overage is discussed.

  6. Achieving competences in patient-centred care

    DEFF Research Database (Denmark)

    Lomborg, Kirsten; Nielsen, Else Skånning; Jensen, Annesofie Lunde

    2011-01-01

    Aim: To document the efficacy of a training programme in patient-centred care in which the nursing staff was trained to involve chronic obstructive pulmonary patients in assisted personal body care (APBC). The objectives were to describe the programme and uncover the outcomes. Background: Chronic...... obstructive pulmonary patients suffer from breathlessness and may need comprehensive assistance with personal body care. The patients’ wellbeing may be improved and their integrity safeguarded if nurses are able to involve the patients in accordance with their illness conditions and personal preferences....... The training was time-consuming. Conclusion: A comprehensive training programme can improve nursing competences to action patient-centred and involve severely ill respiratory patients in APBC. Further studies are needed to investigate the efficacy from the patients’ perspective. Relevance to clinical practice...

  7. JOB CENTRE FOR DOMESTIC STAFF IN SWITZERLAND

    CERN Multimedia

    Relations with the Host States Service; http://www.cern.ch/relations/

    2001-01-01

    The Permanent mission of Switzerland to the International Organisations in Geneva has informed CERN that the Geneva Welcome Centre has set up an employment registration desk for the domestic staff of international civil servants. The aim of this pilot project is, on the one hand, to help international civil servants find domestic staff and, on the other hand, to help domestic staff holding an 'F'-type carte de légitimation find employment within 30 days after the expiry of a contract. For more information, please contact the Geneva Welcome Centre, La Pastorale, 106, route de Ferney, Case postale 103, 1211 Genève 20, tel. (+41.22) 918 02 70, fax (+41.22) 918 02 79), http://geneva-international.org/Welcome.E.html.

  8. Institutional profile: the London Centre for Nanotechnology.

    Science.gov (United States)

    Weston, David; Bontoux, Thierry

    2009-12-01

    Located in the London neighborhoods of Bloomsbury and South Kensington, the London Centre for Nanotechnology is a UK-based multidisciplinary research center that operates at the forefront of science and technology. It is a joint venture between two of the world's leading institutions, UCL and Imperial College London, uniting their strong capabilities in the disciplines that underpin nanotechnology: engineering, the physical sciences and biomedicine. The London Centre for Nanotechnology has a unique operating model that accesses and focuses the combined skills of the Departments of Chemistry, Physics, Materials, Medicine, Electrical and Electronic Engineering, Mechanical Engineering, Chemical Engineering, Biochemical Engineering and Earth Sciences across the two universities. It aims to provide the nanoscience and nanotechnology required to solve major problems in healthcare, information processing, energy and the environment.

  9. Emergency Centre Organization and Automated Triage System

    CERN Document Server

    Golding, Dan; Marwala, Tshilidzi

    2008-01-01

    The excessive rate of patients arriving at accident and emergency centres is a major problem facing South African hospitals. Patients are prioritized for medical care through a triage process. Manual systems allow for inconsistency and error. This paper proposes a novel system to automate accident and emergency centre triage and uses this triage score along with an artificial intelligence estimate of patient-doctor time to optimize the queue order. A fuzzy inference system is employed to triage patients and a similar system estimates the time but adapts continuously through fuzzy Q-learning. The optimal queue order is found using a novel procedure based on genetic algorithms. These components are integrated in a simple graphical user interface. Live tests could not be performed but simulations reveal that the average waiting time can be reduced by 48 minutes and priority is given to urgent patients

  10. Danish Polymer Centre annual report 2001

    DEFF Research Database (Denmark)

    Hassager, O.; Hvilsted, S.; Mortensen, Kell

    The centre is a collaboration between the Risø National Laboratory and the Technical University of Denmark (DTU). At the DTU the Department of Chemical Engineering and the Department of Manufacturing Engineering and Management participate in the centre.From 2001 the Polymer Department at Risø...... campus in Lyngby as shown in the pictures on this page. In addition to well equipped laboratories at Risø which will be expanded in 2002 and 2003, thesefacilities provide a common ground for polymer chemists, polymer physicists, chemical engineers and mechanical engineers from the two institutions...... coordinates the activities at Risø From the outset it was considered important with common laboratories to obtain the full effect of the collaboration between the two departments at the DTU and Risø NationalLaboratory. In 2001 new laboratories for polymer research and education were established at the DTU...

  11. Danish Polymer Centre annual report 2001

    DEFF Research Database (Denmark)

    Hassager, O.; Hvilsted, S.; Mortensen, Kell

    The centre is a collaboration between the Risø National Laboratory and the Technical University of Denmark (DTU). At the DTU the Department of Chemical Engineering and the Department of Manufacturing Engineering and Management participate in the centre.From 2001 the Polymer Department at Risø coo....... The Annual Report for 2001 represents therefore the first report from a period in which the new facilitieshave been utilized to full advantage....... coordinates the activities at Risø From the outset it was considered important with common laboratories to obtain the full effect of the collaboration between the two departments at the DTU and Risø NationalLaboratory. In 2001 new laboratories for polymer research and education were established at the DTU...

  12. [The development process of colon cancer centres].

    Science.gov (United States)

    Sahm, M; Wesselmann, S; Kube, R; Schöffel, N; Pross, M; Lippert, H; Kahl, S

    2013-02-01

    Colon carcinomas are the most common malignant tumours in the Western world. Important findings about the overall quality of medical care have been reported in multi-centre observational studies. A quality enhancement of therapeutic care can be achieved by an additional increase in diagnostic and therapeutic measures in the interdisciplinary setting. The development of colon cancer centres improves the chance to objectively observe the results of medical care induced by the development of an interdisciplinary and cross-sectoral unit that includes a comprehensive medical care for patients. The implementation of the current medical findings based on evidence in clinical routine, the inspection of the usage of guidelines by external specialists as part of an audit and the continuous correction of analysed deficits in the course of treatment guarantee a continuous improvement of service.

  13. It's all change at the Computer Centre

    CERN Multimedia

    Laëtitia Pedroso

    2011-01-01

    The IT and EN Departments are modernising the infrastructure of the Computer Centre to improve the conditions in which the equipment has to operate and to increase capacity. The construction work has already begun and is due to be completed in October 2012.   Every year CERN experiences around ten power cuts lasting from less than a second to several hours. In most cases the two protection systems - the UPS* and the diesel generators – are able to ensure that the operation of the Computer Centre is not affected. As Vincent Doré, the project leader for the IT Department, and Paul Pepinster, the EN Department's technical coordinator in charge of modernising the infrastructure, explains: "Building 513 has two types of computing facilities – the "non-critical" ones, such as the servers for "off-line" computing, which have UPS systems ensuring that they can operate for 10 minutes after a power cut, and the "critical&...

  14. Approaches to Software Engineering: A Human-Centred Perspective

    OpenAIRE

    Bannon, Liam J.

    2010-01-01

    International audience; The field of software engineering has been evolving since its inception in 1968. Arguments as to the exact nature of the field, whether it should be conceived as a real engineering profession, the role of formal methods, whether it is as much an art as a science, etc., continue to divide both practitioners and academics. My purpose here is not to debate these particular topics, but rather to approach the field from the outside, coming as I do from a long period of invo...

  15. Photosynthetic Reaction Centres-from Basic Research to Application

    Directory of Open Access Journals (Sweden)

    László NAGY

    2010-06-01

    Full Text Available There is no doubt that studying the photosynthetic conversion of light into chemical energy is extremely important in many points of view; e.g., 1 technical-in order to improve the utilization of the solar energy; 2 food production-to improve the photosynthetic production of plants in agriculture; 3 ecology-keeping the primer production in ecosystems in the biosphere balanced, etc. In the photosynthetic reaction centre protein, RC, light energy is converted by a quantum yield of almost unity. There is no such a system designed by human which is able to do that. The RC purified from purple bacteria provides an extremely unique system for studying the requirements for high efficiency conversion of light into electrochemical energy. Thanks to the recent structural (e.g. crystallography (Nobel prize to Michel, Deisenhofer, Huber and functional (Nobel prize to Marcus results together with the works of molecular biology, computer- and electro-techniques, a wealth of information made a relatively clear picture about the kinetics, energetics and stabilization of electron transport within this protein that opens possibilities for new generation practical applications. In this paper we provide a short summary of fields in which the reaction centre protein can be important from practical points of view.

  16. Training science centre Explainers. The Techniquest experience

    Directory of Open Access Journals (Sweden)

    Colin Johnson

    2005-12-01

    Full Text Available Techniquest was established in 1986, and in 1995 moved to its current premises at Cardiff Bay, South Wales. This was the first purpose-built science centre in the UK. It receives around 200,000 visitors every year to its exhibition, and to its programmes for schools and public audiences in the theatre, laboratory, discovery room and planetarium. The author joined the Techniquest project in 1985, became a staff member in 1990 and was the Chief Executive from 1997 until his retirement in 2004. Techniquest has three “out-stations” in Wales, and is responsible for the supply and maintenance of exhibits to the Look Out Discovery Centre in Bracknell, England. There is a Techniquest gallery at the Lisbon Pavilhão do Conhecimento - Ciência Viva, and a traveling exhibition, SciQuest, in South Africa which was also supplied by Techniquest. All these centres rely on the effective intervention of “Explainers” (at Techniquest we call them “Helpers” to provide the best possible experience for visitors. At its most demanding, the tasks of an Explainer are varied and intensive, yet there may be times when the duties are mundane or even dull. When you rely on people to act as both hosts and housekeepers, to provide both support and stimulus, and to be both welcoming and watchful, you are asking a great deal. This article raises some of the issues concerned with the recruitment and retention of Explainers, their training and management, and the way in which their role is recognized and valued by the science centre as a whole.

  17. Enhancing Safety at Airline Operations Control Centre

    Directory of Open Access Journals (Sweden)

    Lukáš Řasa

    2015-04-01

    Full Text Available In recent years a new term of Safety Management System (SMS has been introduced into aviation legislation. This system is being adopted by airline operators. One of the groundbased actors of everyday operations is Operations Control Centre (OCC. The goal of this article has been to identify and assess risks and dangers which occur at OCC and create a template for OCC implementation into SMS.

  18. User-Centred Design Using Gamestorming.

    Science.gov (United States)

    Currie, Leanne

    2016-01-01

    User-centered design (UX) is becoming a standard in software engineering and has tremendous potential in healthcare. The purpose of this tutorial will be to demonstrate and provide participants with practice in user-centred design methods that involve 'Gamestorming', a form of brainstorming where 'the rules of life are temporarily suspended'. Participants will learn and apply gamestorming methods including persona development via empathy mapping and methods to translate artefacts derived from participatory design sessions into functional and design requirements.

  19. CMS Centres Worldwide - a New Collaborative Infrastructure

    CERN Document Server

    Taylor, Lucas

    2011-01-01

    Webcasts, and generic Web tools such as CMS-TV for broadcasting live monitoring and outreach information. Being Web-based and experiment-independent, these systems could easily be extended to other organizations. We describe the experiences of using CMS Centres Worldwide in the CMS data-taking operations as well as for major media events with several hundred TV channels, radio stations, and many more press journalists simultaneously around the world.

  20. Birth of a science centre. Italian phenomenology

    Directory of Open Access Journals (Sweden)

    Paola Rodari

    2006-06-01

    Full Text Available In May 2004 the Balì Museum, Planetarium and interactive science museum, was opened to the public in Italy: 35 hands-on exhibits designed according to the interactive tradition of the Exploratorium in San Francisco, an astronomic observatory for educational activities, a Planetarium with 70 places. With a total investment of about three million euros, about two thirds of which were spent on restructuring the splendid eighteenth-century villa in which it is housed, the undertaking may be considered a small one in comparison with other European science centres. Three million euros: perhaps enough to cover the cost of only the splendid circular access ramp to the brand-new Cosmocaixa in Barcelona, an investment of one hundred million euros. But the interesting aspect of the story of the Balì Museum (but also of other Italian stories, as we shall see lies in the fact that this lively and advanced science centre stands in the bucolic region of the Marches, next to a small town of only 800 inhabitants (Saltara, in the Province of Pesaro and Urbino, in a municipal territory that has a total of 5000. Whereas in Italy the projects for science centres comparable with the Catalan one, for example projects for Rome and Turin, never get off the ground, smaller ones are opening in small and medium-sized towns: why is this? And what does the unusual location of the centres entail for science communication in Italy? This Focus does not claim to tell the whole truth about Italian interactive museums, but it does offer some phenomenological cues to open a debate on the cultural, economic and political premises that favour their lives.

  1. Bismuth centred magnetic perovskite: A projected multiferroic

    Energy Technology Data Exchange (ETDEWEB)

    Kundu, Asish K., E-mail: asish.k@gmail.com [Discipline of Physics, Indian Institute of Information Technology, Design and Manufacturing, Dumna Airport Road, Jabalpur 482005 (India); Seikh, Md. Motin [Department of Chemistry, Visva-Bharati University, Santiniketan, West Bengal 731235 (India); Nautiyal, Pranjal [Discipline of Mechanical Engineering, Indian Institute of Information Technology, Design and Manufacturing, Dumna Airport Road, Jabalpur 482005 (India)

    2015-03-15

    In recent time substantial attention has been initiated to understand the physics behind multiferroism and to design new multiferroic materials. BiMnO{sub 3} and BiFeO{sub 3} are the well-studied Bi-centred multiferroic oxides. BiMnO{sub 3} is a ferromagnetic–ferroelectric (metastable) phase and require drastic conditions to synthesize. However, lanthanum substituted BiMnO{sub 3} phases stabilized at ambient pressure. It is thus of major importance to increase the number of ferromagnetic perovskites with Bi cations that could be designed under ambient conditions. In this article, we have presented an up to date report of investigations on Bi-centred magnetic perovskites, a prospective material for multiferroic application. Central focus is concentrated on La{sub 0.5}Bi{sub 0.5}MnO{sub 3} perovskite with various substitutions at different levels. A few of these perovskites are found to be of practical importance e.g. La{sub 0.5}Bi{sub 0.5}Mn{sub 0.67}Co{sub 0.33}O{sub 3} with high dielectric permittivity coupled with ferromagnetism. A comprehensive analysis of different physical functionalities and their interrelation for a wide range of compositions of these Bi-centred perovskites is presented. It has been found that the complex magnetic behaviour originates from mixed valence metal ions. The ferroelectricity is associated with the 6s{sup 2} lone pair of Bi{sup 3+} cations. The magnetic ground state influences the dielectric properties reflecting the multiferroism in a single material. - Highlights: • Multiferroics have attracted increasing attention due to their possible device applications. • Bismuth centred magnetic perovskite is one kind of such promising multiferroic materials. • Ferromagnetic Bi-perovskites, which are synthesized at ambient conditions, have been discussed.

  2. A new visitor centre for CMS

    CERN Multimedia

    2001-01-01

    At the inauguration of the new CMS visitor centre. The CMS experiment inaugurated a new visitor centre at its Cessy site on 14 June. This will allow the thousands of people who come to CERN each year to follow the construction of one the Laboratory's flagship experiments first-hand. CERN receives over 20,000 visitors each year. Until recently, many of them were taken on a guided tour of one of the LEP experiments. With the closure of LEP, however, trips underground are no longer possible, and the Visits' Service has put in place a number of other itineraries (Bulletin 46/2000). Since the CMS detector will be almost entirely constructed in a surface hall, it is now taking a big share of the limelight. The CMS visitor centre has been built on a platform overlooking CMS construction. It contains a set of clear descriptive posters describing the experiment, along with a video projection showing animations and movies about CMS construction. In the coming weeks, a display of CMS detector elements will be added, as...

  3. Upcoming opening of CERN's new Mobility Centre

    CERN Multimedia

    2016-01-01

    On 29 February, CERN’s brand new Mobility Centre opened in the Globe car park. The Centre has been created to cater to the transport needs of everyone at CERN, to simplify procedures and to centralise all the transport services on offer: the rental of CERN bikes and cars, the CERN car-sharing scheme and SIXT car rental.   From 29 February onwards, the Mobility Centre in the Globe car park will be the place to go for all your duty travel needs: rental of CERN cars (with or without the CERN logo), SIXT car rental, CERN bike rental, distribution of cards allowing the use of CERN’s self-service bike- and car-sharing schemes. That same day, the premises currently housing the Car Pool in Building 130 will become the CERN garage, responsible for: upkeep and repairs on CERN bikes, minor maintenance work on CERN vehicles (e.g. replacing windscreen wipers, bulbs and fuses, refilling windscreen washer fluid, pumping up tyres, etc.), arranging and following up the repair and maintenan...

  4. Bismuth centred magnetic perovskite: A projected multiferroic

    Science.gov (United States)

    Kundu, Asish K.; Seikh, Md. Motin; Nautiyal, Pranjal

    2015-03-01

    In recent time substantial attention has been initiated to understand the physics behind multiferroism and to design new multiferroic materials. BiMnO3 and BiFeO3 are the well-studied Bi-centred multiferroic oxides. BiMnO3 is a ferromagnetic-ferroelectric (metastable) phase and require drastic conditions to synthesize. However, lanthanum substituted BiMnO3 phases stabilized at ambient pressure. It is thus of major importance to increase the number of ferromagnetic perovskites with Bi cations that could be designed under ambient conditions. In this article, we have presented an up to date report of investigations on Bi-centred magnetic perovskites, a prospective material for multiferroic application. Central focus is concentrated on La0.5Bi0.5MnO3 perovskite with various substitutions at different levels. A few of these perovskites are found to be of practical importance e.g. La0.5Bi0.5Mn0.67Co0.33O3 with high dielectric permittivity coupled with ferromagnetism. A comprehensive analysis of different physical functionalities and their interrelation for a wide range of compositions of these Bi-centred perovskites is presented. It has been found that the complex magnetic behaviour originates from mixed valence metal ions. The ferroelectricity is associated with the 6s2 lone pair of Bi3+ cations. The magnetic ground state influences the dielectric properties reflecting the multiferroism in a single material.

  5. Criteria for endocrine disrupters: report from the Danish centre on Endocrine Disrupters (CEHOS)

    DEFF Research Database (Denmark)

    Holbech, Henrik; Bjerregaard, Poul; Hass, Ulla;

    The aim of this session is to give a presentation of the report (both ENV and HH) on criteria carried out by the Danish Centre on Endocrine Disrupters (CEHOS) as a project contracted by the Danish Environmental Protection Agency. CEHOS is an interdisciplinary scientific network without walls...... and the main purpose of the Centre is to build and gather new knowledge on endocrine disrupters (EDs) with focus on information needed for the preventive work of the regulatory authorities. The aim of the report was to propose scientific criteria for the identification of ED substances of concern for human...

  6. Patient-centred continuing professional development for Canadian ...

    African Journals Online (AJOL)

    Improving clinical practice skills can enhance a patient-centred model of health care. ... of patient-centred care important, and whether the perceived importance is ... than men but men rated patient communication skills higher than women.

  7. Addiction research centres and the nurturing of creativity: the Kurihama medical and addiction centre-a profile.

    Science.gov (United States)

    Tohyama, Tomomi; Yokoyama, Akira; Matsushita, Sachio; Higuchi, Susumu

    2014-01-01

    The Kurihama Medical and Addiction Center began to conduct research and to provide medical care for alcohol-related problems in 1963, when special alcoholism treatment wards were established in Japan for the first time. At first, the provision of medical care to patients was prioritized. However, training courses for specialists were initiated in 1975, and the Department of Clinical Research was established in 1984, which led to the formation of the present management structure in which the centre's staff are shared by three departments: Medical Care, Clinical Research and Education and Information. The Department of Medical Care provides specialized treatment for alcohol use disorders and medical services for other conditions, including behavioural addictions such as internet addiction and gambling disorder, as well as dementia and other psychiatric disorders. The Departments of Clinical Research and Education and Information are engaged mainly in specialized activities related to alcohol. The Department of Clinical Research conducts research on the epidemiology of alcohol use, the effects of alcohol on health and the treatment of alcohol use disorders in Japan, in cooperation with universities and other research institutions. The Department of Education and Information fosters the human capacity to achieve the primary, secondary and tertiary prevention of alcohol-related problems and the dissemination of information on alcohol. The centre also performs alcohol-related problem prevention activities, government consultations and international collaborative research and personal exchanges, thereby functioning as a central institution for alcohol policy-based medical services and research in Japan.

  8. Proceedings of the 45. annual conference of metallurgists of CIM : interfacial phenomena in fine particle technology : the 6. UBC-McGill-UA international symposium on fundamentals of mineral processing in honor of Professor Janusz S. Laskowski

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Z.; Liu, Q. [Alberta Univ., Edmonton, AB (Canada). Dept. of Chemical and Materials Engineering] (eds.)

    2006-07-01

    This conference, organized by the Mineral Sciences and Engineering Section of the Metallurgical Society of CIM acknowledged that strong economic growth is the driving force behind record high productivity in the mining industry. The industry must strive to meet the higher demand for raw materials while facing the challenge of stringent environmental constraints. The continuing success of the mining industry will depend on efficient and environmentally sound mineral processing, particularly since the industry has been forced to exploit more complex forms of minerals given the gradual depletion of high-grade mineral resources. In addition to shortages in qualified personnel in mineral processing, the industry is currently facing a general reduction in basic research and training programs, resulting in deficiencies in technologies needed to process complex ores. World experts in mineral processing participated at this conference to share their novel research in fine particle processing, applications of atomic force microscopy, flotation research, particle interactions in mineral processing, flotation froths, grinding, rheology and sulphide flotation chemistry. The sessions of the conference were entitled: atomic force microscopy in flotation research particulate interactions; flotation froths, flocculation and dewatering; grinding and rheology surfactants; flotation froths, particle-bubble interactions; sulphide flotation; and, general flotation froths. The conference featured 37 presentations, of which 6 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  9. Energy Efficiency Improvements Using DC in Data Centres

    OpenAIRE

    Bergqvist, Sofia

    2011-01-01

    The installed power usage in a data centre will often amount to several megawatts (MW). Thetotal power consumption of the data centres in the world is comparable to that of the airtraffic. The high energy costs and carbon dioxide emissions resulting from the operation of adata centre call for alternative, more efficient, solutions for the power supply design. Oneproposed solution to decrease the energy usage is to use a direct current power supply (DCUPS) for all the servers in the data centr...

  10. A designated centre for people with disabilities operated by Offaly Centre for Independent Living (Offaly CIL), Offaly

    LENUS (Irish Health Repository)

    Ohmann, Christian

    2011-03-22

    Abstract Background A recent survey has shown that data management in clinical trials performed by academic trial units still faces many difficulties (e.g. heterogeneity of software products, deficits in quality management, limited human and financial resources and the complexity of running a local computer centre). Unfortunately, no specific, practical and open standard for both GCP-compliant data management and the underlying IT-infrastructure is available to improve the situation. For that reason the "Working Group on Data Centres" of the European Clinical Research Infrastructures Network (ECRIN) has developed a standard specifying the requirements for high quality GCP-compliant data management in multinational clinical trials. Methods International, European and national regulations and guidelines relevant to GCP, data security and IT infrastructures, as well as ECRIN documents produced previously, were evaluated to provide a starting point for the development of standard requirements. The requirements were produced by expert consensus of the ECRIN Working group on Data Centres, using a structured and standardised process. The requirements were divided into two main parts: an IT part covering standards for the underlying IT infrastructure and computer systems in general, and a Data Management (DM) part covering requirements for data management applications in clinical trials. Results The standard developed includes 115 IT requirements, split into 15 separate sections, 107 DM requirements (in 12 sections) and 13 other requirements (2 sections). Sections IT01 to IT05 deal with the basic IT infrastructure while IT06 and IT07 cover validation and local software development. IT08 to IT015 concern the aspects of IT systems that directly support clinical trial management. Sections DM01 to DM03 cover the implementation of a specific clinical data management application, i.e. for a specific trial, whilst DM04 to DM12 address the data management of trials across the unit

  11. The job demands-resources model of work engagement in South African call centres

    Directory of Open Access Journals (Sweden)

    Yolandi Janse van Rensburg

    2013-09-01

    Full Text Available Orientation: A ‘sacrificial human resource strategy’ is practised in call centres, resulting in poor employee occupational health. Consequently, questions are posed in terms of the consequences of call centre work and which salient antecedent variables impact the engagement and wellbeing of call centre representatives.Research purpose: Firstly, to gauge the level of employee engagement amongst a sample of call centre representatives in South Africa and, secondly, to track the paths through which salient personal and job resources affect this engagement. More specifically, the relationships between sense of coherence, leadership effectiveness, team effectiveness and engagement were investigated, thus testing the Job Demands-Resources model of work engagement.Motivation for the study: To present an application of the Job Demands-Resources model of work engagement in a call centre environment in order to diagnose current ills and consequently propose remedies.Research design: A cross-sectional survey design was used and a non-probability convenient sample of 217 call centre representatives was selected. The measuring instruments comprise the Utrecht Work Engagement Scale to measure engagement, the Team Diagnostic Survey to measure team effectiveness, the leadership practices inventory to gauge leadership effectiveness, and the Orientation to Life Questionnaire to measure sense of coherence. A series of structural equation modelling analyses were performed.Main findings: Contrary to the ‘electronic sweatshop’ image attached to call centre jobs depicted in the literature, results show a high level of employee engagement for call centre representatives in the sample. Also, personal resources such as sense of coherence and job resources such as team effectiveness related significantly to engagement. A non-significant relationship exists between leadership effectiveness and engagement.Practical/managerial implications: Both the content and

  12. The job demands-resources model of work engagement in South African call centres

    Directory of Open Access Journals (Sweden)

    Yolandi Janse van Rensburg

    2013-01-01

    Full Text Available Orientation: A ‘sacrificial human resource strategy’ is practised in call centres, resulting in poor employee occupational health. Consequently, questions are posed in terms of the consequences of call centre work and which salient antecedent variables impact the engagement and wellbeing of call centre representatives.Research purpose: Firstly, to gauge the level of employee engagement amongst a sample of call centre representatives in South Africa and, secondly, to track the paths through which salient personal and job resources affect this engagement. More specifically, the relationships between sense of coherence, leadership effectiveness, team effectiveness and engagement were investigated, thus testing the Job Demands-Resources model of work engagement.Motivation for the study: To present an application of the Job Demands-Resources model of work engagement in a call centre environment in order to diagnose current ills and consequently propose remedies.Research design: A cross-sectional survey design was used and a non-probability convenient sample of 217 call centre representatives was selected. The measuring instruments comprise the Utrecht Work Engagement Scale to measure engagement, the Team Diagnostic Survey to measure team effectiveness, the leadership practices inventory to gauge leadership effectiveness, and the Orientation to Life Questionnaire to measure sense of coherence. A series of structural equation modelling analyses were performed.Main findings: Contrary to the ‘electronic sweatshop’ image attached to call centre jobs depicted in the literature, results show a high level of employee engagement for call centre representatives in the sample. Also, personal resources such as sense of coherence and job resources such as team effectiveness related significantly to engagement. A non-significant relationship exists between leadership effectiveness and engagement.Practical/managerial implications: Both the content and

  13. Tele-centres as a way of achieving universal access

    DEFF Research Database (Denmark)

    Falch, Morten; Anyimadu, Amos

    2003-01-01

    The success of tele-centres in Ghana is discussed. The tele-centres offer a low cost opportunity to empower local communities in developed and developing countries to meet the challenges of the information society. The tele-centres can also contribute more directly to the supply of non-commercial...

  14. Reaching the Students that Student-Centred Learning Cannot Reach

    Science.gov (United States)

    Hockings, Christine

    2009-01-01

    Student-centred learning has the potential to engage a more academically diverse student body than the more conventional teacher-centred approaches. In spite of the evidence in favour of student-centred learning, a recent study showed that it was ineffective for around 30% of undergraduates in a large and diverse group studying business operations…

  15. Closing the gender leadership gap: a multi-centre cross-country comparison of women in management and leadership in academic health centres in the European Union.

    Science.gov (United States)

    Kuhlmann, Ellen; Ovseiko, Pavel V; Kurmeyer, Christine; Gutiérrez-Lobos, Karin; Steinböck, Sandra; von Knorring, Mia; Buchan, Alastair M; Brommels, Mats

    2017-01-06

    and newly created management structures. Developing comprehensive gender-sensitive health workforce monitoring systems and comparing progress across academic health centres in Europe could help to identify the gender leadership gap and utilise health human resources more effectively.

  16. The "Magic" of Tutorial Centres in Hong Kong: An Analysis of Media Marketing and Pedagogy in a Tutorial Centre

    Science.gov (United States)

    Koh, Aaron

    2014-01-01

    Why do more than three-quarters of Hong Kong's senior secondary students flock to tutorial centres like moths to light? What is the "magic" that is driving the popularity of the tutorial centre enterprise? Indeed, looking at the ongoing boom of tutorial centres in Hong Kong (there are almost 1,000 of them), it is difficult not to ask…

  17. Low energy use at Vaestervik sports centre

    Energy Technology Data Exchange (ETDEWEB)

    2009-05-15

    Vaestervik, in south Sweden, has saved both energy and money since modern energy efficiency equipment was installed in its swimming pool and bowling alley. Energy use in the sports centre has so far fallen by around 830 MWh/year, and operating costs have been reduced by efficient heat recovery. Energy efficiency at the Vaestervik sports centre is a good example of how a local authority can save energy and money by installing modern equipment for ventilation and heat recovery in a facility with high energy consumption. The well-used sports centre, including a swimming pool and bowling alley, is in central Vaestervik. In 1999 the Municipality received grants from the local investment programme (LIP) to improve the facility's energy efficiency. An efficient ventilation system with a dehumidifier and heat exchanger was installed at the swimming pool, reducing the need to introduce cold air. In addition the bowling alley, which did not have heat recovery, was given a modern heat-recovery plant. - Lower operating costs due to efficient heat recovery. - Reduced energy use (electricity and district heating) for the plant at around 830 MWh/year. The modern and highly efficient units for heat recovery, dehumidification and heat exchange result in lower operating costs and reduced energy use, which means that the Municipality of Vaestervik saves energy and money. Installation at the swimming pool resulted in slightly higher air humidity, but a relative humidity of 60% is common in swimming pools and difficult to reduce without inconveniencing bathers. A new fan room installed in the roof contributed to higher than anticipated costs, but the financial and economic gains outweigh these. New frequency-controlled circulation pumps for the pool water were installed in 2007. They are to have occupancy control capability, giving a further improvement of energy saving and heat recovery

  18. Optimal catchment area and primary PCI centre volume revisited

    DEFF Research Database (Denmark)

    Schoos, Mikkel Malby; Pedersen, Frants; Holmvang, Lene

    2015-01-01

    AIMS: The currently stated optimal catchment population for a pPCI centre is 300,000-1,100,000, resulting in 200-800 procedures/year. pPCI centres are increasing in number even within small geographic areas. We describe the organisation and quality of care after merging two high-volume centres....... The quality of a centre reflects governance, training, resources and pre-hospital triage, rather than catchment population and STEMI incidence, as long as a minimum volume is guaranteed. Resources can be utilised better by merging neighbouring centres, without negative effects on quality of care....

  19. The INTEGRAL science data centre (ISDC)

    DEFF Research Database (Denmark)

    Courvoisier, T.J.L.; Walter, Rasmus; Beckmann, V.;

    2003-01-01

    The INTEGRAL Science Data Centre (ISDC) provides the INTEGRAL data and means to analyse them to the scientific community. The ISDC runs a gamma ray burst alert system that provides the position of gamma ray bursts on the sky within seconds to the community. It operates a quick-look analysis...... of the data within few hours that detects new and unexpected sources as well as it monitors the instruments. The ISDC processes the data through a standard analysis the results of which are provided to the observers together with their data....

  20. going for the centre of the world

    Directory of Open Access Journals (Sweden)

    Moses Iten

    2005-08-01

    Full Text Available “He wants to go to the centre!” exclaims the man I’ve just asked for directions, winking to his friends. They are laying a cement foundation for a house, amongst wooden huts with dirt floors. An upgrade. They giggle and wave for me to continue along the only road. At each house - spaced fifty metres from each other - I keep asking for the same directions. “El Centro?” a lady asks me at one of the many wooden kiosks, that all seem to sell the same few things, “bueno, just take a left at the next crossing.”

  1. Dynamics of B cells in germinal centres.

    Science.gov (United States)

    De Silva, Nilushi S; Klein, Ulf

    2015-03-01

    Humoral immunity depends on the germinal centre (GC) reaction during which somatically mutated high-affinity memory B cells and plasma cells are generated. Recent studies have uncovered crucial cues that are required for the formation and the maintenance of GCs and for the selection of high-affinity antibody mutants. In addition, it is now clear that these events are promoted by the dynamic movements of cells within and between GCs. These findings have resolved the complexities of the GC reaction in greater detail than ever before. This Review focuses on these recent advances and discusses their implications for the establishment of humoral immunity.

  2. WHO Collaborating Centre for Acquired Immunodeficiency Syndrome for the Eastern Mediterranean Regional Office, Faculty of Medicine, Kuwait University, Kuwait.

    Science.gov (United States)

    Altawalah, Haya; Al-Nakib, Widad

    2014-01-01

    In the early 1980s, the World Health Organization (WHO) designated the Virology Unit of the Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait, a collaborating centre for AIDS for the Eastern Mediterranean Regional Office (EMRO), recognizing it to be in compliance with WHO guidelines. In this centre, research integral to the efforts of WHO to combat AIDS is conducted. In addition to annual workshops and symposia, the centre is constantly updating and renewing its facilities and capabilities in keeping with current and latest advances in virology. As an example of the activities of the centre, the HIV-1 RNA viral load in plasma samples of HIV-1 patients is determined by real-time PCR using the AmpliPrep TaqMan HIV-1 test v2.0. HIV-1 drug resistance is determined by sequencing the reverse transcriptase and protease regions on the HIV-1 pol gene, using the TRUGENE HIV-1 Genotyping Assay on the OpenGene® DNA Sequencing System. HIV-1 subtypes are determined by sequencing the reverse transcriptase and protease regions on the HIV-1 pol gene using the genotyping assays described above. A fundamental program of Kuwait's WHO AIDS collaboration centre is the national project on the surveillance of drug resistance in human deficiency virus in Kuwait, which illustrates how the centre and its activities in Kuwait can serve the EMRO region of WHO.

  3. KNMI Data Centre: Easy access for all

    Science.gov (United States)

    van de Vegte, John; Som de Cerff, Wim; Plieger, Maarten; de Vreede, Ernst; Sluiter, Raymond; Willem Noteboom, Jan; van der Neut, Ian; Verhoef, Hans; van Versendaal, Robert; van Binnendijk, Martin; Kalle, Henk; Knopper, Arthur; Spit, Jasper; Mastop, Joeri; Klos, Olaf; Calis, Gijs; Ha, Siu-Siu; van Moosel, Wim; Klein Ikkink, Henk-Jan; Tosun, Tuncay

    2013-04-01

    KNMI is the Dutch institute for weather, climate research and seismology. It disseminates weather information to the public at large, the government, aviation and the shipping industry in the interest of safety, the economy and a sustainable environment. To gain insight into long-term developments KNMI conducts research on climate change. Making the knowledge, data and information on hand at KNMI accessible is one core activity. A huge part of the KNMI information is from numerical models, insitu sensor networks and remote sensing satellites. This digital collection is mostly internal only available and is a collection of non searchable , non standardized file formats, lacking documentation and has no references to scientific publications. With the KNMI Data Centre (KDC) project these issues are tackled. In the project a user driven development approach with SCRUM was chosen to get maximum user involvement in a relative short development timeframe. Building on open standards and proven open source technology (which includes in-house developed software like ADAGUC WMS and Portal) resulted in a first release in December 2012 This presentation will focus on the aspects of KDC relating to its technical challenges, the development strategy and the initial usage results of the data centre.

  4. ALICE opens its new nerve centre

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    Twenty-nine fully equipped and ergonomic workstations, one meeting area and 11 large format screens in a completely refurbished room: the ALICE Run Control Centre (ARC) implements the best and newest solutions for its shift workers and expert operators, including access for persons with reduced mobility and very soon a magic window for Point 2 visitors.   The ALICE Run Control Centre. “Our initial intention was just to optimise the old layout,” says Federico Ronchetti from Laboratori Nazionali di Frascati (Italy), a CERN scientific associate currently appointed as ALICE Run Coordinator and person in charge of the ALICE Consolidation Task Force. “However, during the review process, we carried out a study of all the existing control rooms at CERN and became aware we needed a radical change. Hence we started planning a complete redesign of the workspace.” Designed and equipped over many years, the old ALICE control room did not have enough space to fit al...

  5. CMS tracker slides into centre stage

    CERN Multimedia

    2006-01-01

    As preparations for the magnet test and cosmic challenge get underway, a prototype tracker has been carefully inserted into the centre of CMS. The tracker, in its special platform, is slowly inserted into the centre of CMS. The CMS prototype tracker to be used for the magnet test and cosmic challenge coming up this summer has the same dimensions -2.5 m in diameter and 6 m in length- as the real one and tooling exactly like it. However, the support tube is only about 1% equipped, with 2 m2 of silicon detectors installed out of the total 200 m2. This is already more than any LEP experiment ever used and indicates the great care needed to be taken by engineers and technicians as these fragile detectors were installed and transported to Point 5. Sixteen thousand silicon detectors with a total of about 10 million strips will make up the full tracker. So far, 140 modules with about 100 000 strips have been implanted into the prototype tracker. These silicon strips will provide precision tracking for cosmic muon...

  6. Sanitary condition of electrical hand dryers in toilets of shopping centres in Kraków

    Directory of Open Access Journals (Sweden)

    Anna Lenart-Boroń

    2015-06-01

    Full Text Available Introduction. Shopping habits have changed over the past several years and consumers choose shopping centres, where they can spend time and visit restaurants. People usually wash hands before meals, but toilets in shopping centres are visited by hundreds of users every day which makes their cleanliness questionable. Therefore, the aim of this study was to assess the sanitary condition of electrical hand dryers in toilets of the selected shopping centres in Kraków. Material and methods. Air was sampled at the outlet of electrical hand dryers and surface swabs of hand dryers were taken in toilets of five shopping centres. Air sampling was conducted using the MAS-100 impactor. The number of mesophilic bacteria, fungi, actinomycetes, staphylococci and Escherichia coli was determined. The results of air analyses were compared with the limits provided by the Polish Standards on air quality. Results. The number of microorganisms varied between the studied centres. In terms of mesophilic bacteria and fungi the air was unpolluted. The concentration of actinomycetes however significantly exceeded the limits set by the Polish Standards. Numerous Escherichia coli were found both in the air and in swabs in one of the centres. However the number of E. coli and staphylococci did not exceed the minimum infective dose. Conclusions. The studies showed high concentrations of airborne actinomycetes and staphylococci. Also the presence of E. coli in the air and swabs allows the conclusion that legal regulations for concentrations of airborne microorganisms are necessary to make people aware of this problem. However, it was found that using electrical hand dryers does not have impact on human health.

  7. Project for a renewable energy research centre

    Directory of Open Access Journals (Sweden)

    Andrea Giachetta

    2011-04-01

    Full Text Available In Liguria, where sustainable approaches to the design, construction and management of buildings enjoy scant currency, the idea of a company from Milan (FERA s.r.l. setting up a research centre for studies into renewable energy resources, could well open up very interesting development opportunities.The project includes: environmental rehabilitation (restoration projects; strategies for the protection of water resources and waste management systems; passive and active solar systems (solar thermal and experiments with thermodynamic solar energy; hyperinsulation systems, passive cooling of buildings; use of natural materials; bio-climatic use of vegetation. The author describes the project content within the context of the multidisciplinary work that has gone into it.

  8. MATERNAL MORTALITY IN A TERTIARY CARE CENTRE

    Directory of Open Access Journals (Sweden)

    Harpreet

    2013-06-01

    Full Text Available ABSTRACT: Maternal Mortality in A Tertiary Care Centre. OBJECTIVE: To study maternal mortality and the complications leading to maternal death. METHODS: A retrospective study of hospital record to study maternal mortality and its causes over 3 years from January 2010 to December 2012. RESULTS: There were a total of 58 maternal deaths out of 2823 live births giving a maternal mortality ratio of 2054.55 per one lakh live births. Unbooked and late referrals account for 77.58% of maternal deaths. The majority of deaths around 75.86% were in 20-30 years age group. Haemorrhage was the commonest causes of death (24.12% followed by sepsis (18.96% and pregnancy induced hypertension 15.51% Anemia contributed to the most common indirect cause of maternal morality. CONCLUSION: Haemorrhage, sepsis and pregnancy induced hypertension including eclampsia were the direct major causes of death. Anaemia and cardiac diseases were other indirect causes of death.

  9. Patient-centred Prevention among PAD Patients

    DEFF Research Database (Denmark)

    Pii, Kathrine Hoffmann

    2014-01-01

    -centredness is thus promoted as a way to organize health more effectively (in terms of cost and treatment outcomes) and as a way to ensure patients’ autonomy and fundamental right to make their own decisions regarding their treatment. Critical voices within social and nursing theory have however argued...... that the patient-centred approach does not ensure patient autonomy, but continues to be organized according to biomedical regimes and thereby carry on a paternalistic approach. In this paper, I present findings from a PhD project, which investigates how the ideal of patient-centredness is practiced in the case...... as a relational property/entity, which implies that professionals intervene in the development of patients’ autonomy by expanding their capacity to make and actualize choices. The dilemma regarding the concern to ensure patient autonomy and still wanting patients to make the “right” choices is not one...

  10. Learner-Centred Education in International Perspective

    Directory of Open Access Journals (Sweden)

    Michele Schweisfurth

    2013-04-01

    Full Text Available Abstract: This article provides an overview of Learner-Centred ducation (LCE as a travelling policy and outlines some of the arguments and pathways that have been used to fuel its travel. Despite the rich promises it offers and its proliferation as a global phenomenon and national policy, there is evidence that implementation and changes to classroom practice have proved to be problematic in many contexts. This seems particularly true in developing countries, and the article explores some of the reasons behind these perennial gaps. It concludes by arguing for the importance of both a birds-eye view and local understandings in researching and operationalising LCE, and suggests ways that the local and the global might be reconciled so that the promise of LCE is not lost in translation.

  11. Children's Centre "3 in 1 - together"

    Science.gov (United States)

    Gancheva, Hristina

    2013-04-01

    "There are only two ways to life your live. One is as though nothing is a miracle. The other is as though everything is a miracle." Albert Einstein Children's Centre "3 in 1" is an extracurricular unit linked to the High School of Zlatartitsa, St. Cyril and St. Methodius, accomplished with the help of the municipality and many volunteers from the local community. With its activity it forms in children patriotic spirit, love for nature, active citizenship, and an impulse for a healthy life through communication with nature, saving the traditions and history, insurance of equality of the kids of the local five ethnicities and participation in activities in the sphere of science, art, sport and tourism. The educational work is mainly directed towards kids with difficulties with communication, hyperactivity, aggression, problems in their families, or those deprived of parental care. For a few years in the Children's Centre there have been clubs of interests: "Gardeners" - kids cultivate a garden. They plow, dig, plant, put in, irrigate and weed under the watch of Ms Stafka Nikolova, parents, and volunteers of the local community. The ecologically clean products - vegetables and fruits, kids use to cook delicious meals, sell, or give away. Weeds are also utilized; they are making herbarium out of them. "Cooks" - "What to have for lunch, when mom is out?". One can learn a lot of wonderful recipes from the club "Cooks". Products are own made, raised with love. In 2010, on the on the annual traditional holiday of the garden soup in Zlataritsa, the little cooks won third prize for making a delicious vegetable soup. On the same day, the 26 years old Nadezhda Savova, Cultural and Social Anthropology PhD in Princeton, founded the second community bakery in Bulgaria in Children's Centre "3 in1". Nadezhda Savova was declared traveler of 2012 by National Geographic. After the baking house in Gabrovo and Zlataritsa, Nadezhda also founded such projects in Sofia, Varna and Ruse

  12. Stimulated emission from NV centres in diamond

    CERN Document Server

    Jeske, Jan; McGuinness, Liam P; Reineck, Philip; Johnson, Brett C; McCallum, Jeffrey C; Jelezko, Fedor; Volz, Thomas; Cole, Jared H; Gibson, Brant C; Greentree, Andrew D

    2016-01-01

    Stimulated emission is the process fundamental to laser operation, thereby producing coherent photon output. Despite negatively-charged nitrogen-vacancy (NV$^-$) centres being discussed as a potential laser medium since the 1980's, there have been no definitive observations of stimulated emission from ensembles of NV$^-$ to date. Reasons for this lack of demonstration include the short excited state lifetime and the occurrence of photo-ionisation to the neutral charge state by light around the zero-phonon line. Here we show both theoretical and experimental evidence for stimulated emission from NV$^-$ states using light in the phonon-sidebands. Our system uses a continuous wave pump laser at 532 nm and a pulsed stimulating laser that is swept across the phononic sidebands of the NV$^-$. Optimal stimulated emission is demonstrated in the vicinity of the three-phonon line at 700 nm. Furthermore, we show the transition from stimulated emission to photoionisation as the stimulating laser wavelength is reduced fro...

  13. Data communication at the CERN computer centre

    CERN Document Server

    Bruins, T; Pieters, R; Slettenhaar, Hendrik J; Van de Kerk, P

    1972-01-01

    The growing interest for on-line computer service and process control at CERN decentralises certain computer activities. Small process computers, remote batch stations and user terminals are to be backed by a powerful central computer. The present data network is principally star shaped. At the centre of it is a CDC 6600-6500 computer combination. It has a front end CDC 3100 computer with a Hewlett Packard 2116 as multiplexer. Some details about the fast parallel connections between the CDC 3100 and the HP 2116B are given in the paper, as well as descriptions of some computer simulation techniques used to test the present systems. Finally some plans on a future network are given. (12 refs).

  14. Communications Centre Model in Insurance Business

    Directory of Open Access Journals (Sweden)

    Danijel Bara

    2013-07-01

    Full Text Available The aim of this paper is to define a communications centre model in an insurance company that essentially has two objectives. The first objective is focused on providing quality support with the sales process thereby creating a strategic advantage over the competition while the second objective is focused on improving the link between internal organizational units whose behaviour can often render decision-making at all levels difficult. The function of sales is fundamental for an insurance company. Whether an insurance company will fulfil its basic function, which is transfer of risk from the insured party to the insurer who agrees tonreimburse incidental damages to the damaged party and distribute them among all members of the risk group on the principles of reciprocity and solidarity, depends on successful sales and billing (Andrijašević & Petranović, 1999. For an insurance company to operate successfully in a demanding market, it is necessary to meet the needs of potential clients who then must be at the centre of all the activities of the insurer. A satisfied policy holder, who is respected by the insurer as a partner, is a guarantee that the sales of insurance services will be successful and that the insured party will come back to the same insurance company. In the era of globalization and all-pervading new technologies and modes of communication, policy holders need to be able to communicate with insurance company employees. Quality communication is a good foundation for a sales conversation. A fast flow of all types of information within an organisation using a single communication module makes decision-making at all levels quicker and easier.

  15. Collaborating at a distance: operations centres, tools, and trends

    Energy Technology Data Exchange (ETDEWEB)

    Gottschalk, Erik E.; /Fermilab

    2009-05-01

    Successful operation of the LHC and its experiments is crucial to the future of the worldwide high-energy physics program. Remote operations and monitoring centres have been established for the CMS experiment in several locations around the world. The development of remote centres began with the LHC{at}FNAL ROC and has evolved into a unified approach with distributed centres that are collectively referred to as 'CMS Centres Worldwide'. An overview of the development of remote centres for CMS will be presented, along with a synopsis of collaborative tools that are used in these centres today and trends in the development of remote operations capabilities for high-energy physics.

  16. The Centre of Mass of a Triangular Plate

    Science.gov (United States)

    Slusarenko, Viktor; Rojas, Roberto; Fuster, Gonzalo

    2008-01-01

    We present a derivation for the coordinates of the centre of mass--or centre of gravity--of a homogeneous triangular plate by using scaling and symmetry. We scale the triangular plate by a factor of 2 and divide its area into four plates identical to the original. By symmetry, we assert that the centre of mass of two identical masses lies at the…

  17. VIA Ageing and Dementia, Research Centre, VIA University College, Denmark

    DEFF Research Database (Denmark)

    Munk, Karen Pallesgaard; Maibom, Kirsten

    2016-01-01

    New research environments are evolving in Denmark. Following a legislative change in 2013, the conditions for research in University Colleges have been improved. University Colleges (professionshøjskoler) includes the undergraduate-level educations such as nursing, occupational therapy and physio...... and physiotherapy and related research centres. The article describes such a research centre, namely VIA Ageing and Dementia, Research Centre, VIA University College, Denmark....

  18. Crystalline roof glazing - Westside shopping centre, Berne; Kristalline Dachverglasungen

    Energy Technology Data Exchange (ETDEWEB)

    Enkerli, W.

    2009-07-01

    This illustrated article takes a look at the new shopping and leisure centre on the western outskirts of Berne, Switzerland. In particular, the roof of this unusual building over the motorway with its sloping walls and zig-zag design is looked at. The centre's shopping mall, adventure baths and spa, a multiplex cinema, an old peoples' home and a hotel are briefly discussed, as is the embedding of the centre in its suburban environment. The roof construction with its crystalline skylights is examined and discussed in detail. The centre's building technical services are also briefly commented on.

  19. Defining and describing birth centres in the Netherlands - a component study of the Dutch Birth Centre Study.

    Science.gov (United States)

    Hermus, M A A; Boesveld, I C; Hitzert, M; Franx, A; de Graaf, J P; Steegers, E A P; Wiegers, T A; van der Pal-de Bruin, K M

    2017-07-03

    During the last decade, a rapid increase of birth locations for low-risk births, other than conventional obstetric units, has been seen in the Netherlands. Internationally some of such locations are called birth centres. The varying international definitions for birth centres are not directly applicable for use within the Dutch obstetric system. A standard definition for a birth centre in the Netherlands is lacking. This study aimed to develop a definition of birth centres for use in the Netherlands, to identify these centres and to describe their characteristics. International definitions of birth centres were analysed to find common descriptions. In July 2013 the Dutch Birth Centre Questionnaire was sent to 46 selected Dutch birth locations that might qualify as birth centre. Questions included: location, reason for establishment, women served, philosophies, facilities that support physiological birth, hotel-facilities, management, environment and transfer procedures in case of referral. Birth centres were visited to confirm the findings from the Dutch Birth Centre Questionnaire and to measure distance and time in case of referral to obstetric care. From all 46 birth locations the questionnaires were received. Based on this information a Dutch definition of a birth centre was constructed. This definition reads: "Birth centres are midwifery-managed locations that offer care to low risk women during labour and birth. They have a homelike environment and provide facilities to support physiological birth. Community midwives take primary professional responsibility for care. In case of referral the obstetric caregiver takes over the professional responsibility of care." Of the 46 selected birth locations 23 fulfilled this definition. Three types of birth centres were distinguished based on their location in relation to the nearest obstetric unit: freestanding (n = 3), alongside (n = 14) and on-site (n = 6). Transfer in case of referral was necessary for all

  20. [Tissue bank of the National Centre for Tumour Disease. An innovative platform for translational tumour].

    Science.gov (United States)

    Herpel, E; Koleganova, N; Schirmacher, P

    2008-11-01

    The tissue bank of the National Centre for Tumour Diseases (NCT) in Heidelberg, Germany, was founded in 2005 by the University Hospital of Heidelberg and the German Cancer Research Centre as a section of the NCT. It is a nonprofit organization with a completely evaluated legal and ethical framework and supports the Comprehensive Cancer Centre concept. Its main aim is the acquisition and characterization of fresh-frozen and paraffin-embedded human tissues according to the standards of good scientific practice and the promotion of interdisciplinary tumour research of the comprehensive cancer centre and its cooperating partners. It also offers expert project assistance: a project leader can submit a short proposal, and the tissue collecting/preparing process will be performed in cooperation with a specialised pathologist and, if applicable, an experienced clinical researcher. The tissue bank is also a central platform for further developing of innovative technologies for tissue handling, e.g. multi-tissue-array and virtual microscopy, with links to digital image analysis and bioinformatics. Thus, the NCT tissue bank represents a model for innovative biobanking and for institutions with active interdisciplinary cancer research.

  1. A sit-ski design aimed at controlling centre of mass and inertia.

    Science.gov (United States)

    Langelier, Eve; Martel, Stéphane; Millot, Anne; Lessard, Jean-Luc; Smeesters, Cécile; Rancourt, Denis

    2013-01-01

    This article introduces a sit-ski developed for the Canadian Alpine Ski Team in view of the Vancouver 2010 Paralympic games. The design is predominantly based on controlling the mass distribution of the sit-ski, a critical factor in skiing performance and control. Both the antero-posterior location of the centre of mass and the sit-ski moment of inertia were addressed in our design. Our design provides means to adjust the antero-posterior centre of mass location of a sit-ski to compensate for masses that would tend to move the antero-posterior centre of mass location away from the midline of the binding area along the ski axis. The adjustment range provided is as large as 140 mm, thereby providing sufficient adaptability for most situations. The suspension mechanism selected is a four-bar linkage optimised to limit antero-posterior seat movement, due to suspension compression, to 7 mm maximum. This is about 5% of the maximum antero-posterior centre of mass control capacity (151 mm) of a human participant. Foot rest inclination was included in the design to modify the sit-ski inertia by as much as 11%. Together, these mass adjustment features were shown to drastically help athletes' skiing performance.

  2. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation

    Science.gov (United States)

    Romero-Camarero, Isabel; Jiang, Xiaoyu; Natkunam, Yasodha; Lu, Xiaoqing; Vicente-Dueñas, Carolina; Gonzalez-Herrero, Ines; Flores, Teresa; Garcia, Juan Luis; McNamara, George; Kunder, Christian; Zhao, Shuchun; Segura, Victor; Fontan, Lorena; Martínez-Climent, Jose A.; García-Criado, Francisco Javier; Theis, Jason D.; Dogan, Ahmet; Campos-Sánchez, Elena; Green, Michael R.; Alizadeh, Ash A.; Cobaleda, Cesar; Sánchez-García, Isidro; Lossos, Izidore S.

    2012-01-01

    The human germinal centre associated lymphoma (HGAL) gene is specifically expressed in germinal centre B-lymphocytes and germinal centre-derived B-cell lymphomas, but its function is largely unknown. Here we demonstrate that HGAL directly binds Syk in B-cells, increases its kinase activity upon B-cell receptor stimulation and leads to enhanced activation of Syk downstream effectors. To further investigate these findings in vivo, HGAL transgenic mice were generated. Starting from 12 months of age these mice developed polyclonal B-cell lymphoid hyperplasia, hypergammaglobulinemia and systemic reactive AA amyloidosis, leading to shortened survival. The lymphoid hyperplasia in the HGAL transgenic mice are likely attributable to enhanced B-cell receptor signalling as shown by increased Syk phosphorylation, ex vivo B-cell proliferation and increased RhoA activation. Overall, our study shows for the first time that the germinal centre protein HGAL regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B-cell lymphoproliferation. PMID:23299888

  3. The Centres for Environment-friendly Energy Research (FME)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    High expectations for Norway's Centres for Environment-friendly Energy Research (FME).The FME centres address a broad range of areas, allcentral to developing the energy sector of the future. The activities of the eight centres established in 2009 focus on renewable energy, raising energy efficiency, energy planning, and carbon capture and storage (CCS). In 2011 three new FME centres were established which focus on social science-related energy research. The FME scheme is a direct follow-up of the broad-based political agreement on climate policy achieved in the Storting in January 2008, and of the national RandD Energi21 strategy submitted in February 2008 to the Ministry of Petroleum and Energy. In April 2008 the Research Council of Norway's Executive Board decided to launch a process to establish centres for environment-friendly energy research, and a funding announcement was issued that same year. In 2010 it was decided that additional FME centres would be established in the field of social science-related energy research. After a thorough assessment of each project (based on feasibility, scientific merit, potential to generate value creation and innovation, and composition of the consortium) eight applicants were selected to become FME centres in February 2009. A new call for proposals was issued in 2010, and three more centres were awarded FME status in February 2011. The objective of the FME scheme is to establish time-limited research centres which conduct concentrated, focused and long-term research of high international calibre in order to solve specific challenges in the energy sphere. The selected centres must exhibit higher goals, a longer-term perspective and a more concentrated focus than is required under other funding instruments for the same scientific area. The make-up of the centres is critical to achieving this objective. The centres bring together Norway's leading research institutions and key players in private enterprise, the

  4. Reference values for the geometric centre analysis of colonic transit measurements with 111indium-labelled diethylenetriamine penta-acetic acid

    DEFF Research Database (Denmark)

    Madsen, Jan Lysgård; Fuglsang, Stefan; Graff, Jesper

    2003-01-01

    The geometric centre analysis is often used for evaluating colonic transit data obtained by scintigraphy after oral intake of 111indium-labelled diethylenetriamine penta-acetic acid (111In-DTPA). The purpose of this study was to establish reference values for the geometric centre analysis in adult...... humans. Forty-eight healthy volunteers (24 women, 24 men) who were equally distributed among three age groups (young, middle-aged, elderly) were studied. In all subjects the geometric centre of radioactivity in the colon was calculated from abdominal gamma camera images acquired 24, 48, 72, and 96 h...... after oral administration of 111In-DTPA. Overall, the men had a higher geometric centre value than women after both 24 and 48 h indicating a faster progress of colonic contents in men at these time points. At each time point the geometric centre value was higher in both the young and middle...

  5. The LHC Physics Centre at CERN

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Although raw physics data is produced at CERN, thanks to the GRID its analysis is performed in various institutes worldwide. In addition, workshops, conferences and meetings take place all over the world. The physicist community is decentralized, and CERN must continue to provide intellectual leadership. The LHC Physics Centre is the tool that will make this possible.   Until the early days of LEP, a large part of the scientific activity related to CERN’s experiments was strongly centered at the Laboratory. Few places had the infrastructure to host activities such as the working groups preparing the Yellow Reports, and the limited access to information in the pre-web era made CERN the natural place to learn what was happening in the field. “I remember the days when we, the theorists, would come to CERN just to read the most recent preprints, which were reaching CERN's Library before we could get them in our institutes”, says Michelangelo Mangano, a member of the Theo...

  6. The LHC Physics Centre at CERN

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    As the LHC goes on line for its first exploration of the new high-energy frontier, CERN is also getting ready to enhance the support it provides for the analysis and interpretation of the emerging data.    The LHC Physics Centre at CERN (LPCC) has started up over the past couple of months, beginning with a series of initiatives ranging from Workshops to lectures for students. More details about the LPCC will be featured in a forthcoming Bulletin article. In the meantime, you can consult the LPCC web page, now available at http://cern.ch/lpcc. This offers the high energy physics community a portal to the LPCC's activities, as well as to useful resources, tools and information about the LHC physics programme, the progress of accelerator operations, relevant workshops and events around the world, and much more. The LPCC will shortly begin issuing a weekly bulletin of its own, distributed by e-mail. Members of the CERN physics community and subscribers to the CERN Bulletin will receive the ...

  7. Mass Segregation in the Galactic Centre

    CERN Document Server

    Hopman, Clovis

    2010-01-01

    Two-body energy exchange between stars orbiting massive black holes (MBHs) leads to the formation of a power-law density distribution n(r)~r^(-a) that diverges towards the MBH. For a single mass population, a=7/4 and the flow of stars is much less than N(centre (GC) is t_r ~2-3 * 10^(10) yr, a cusp should form in less than a Hubble time. The absence of a visible cusp of old stars in the GC poses a challenge to these models, ...

  8. The Galactic Centre in the Far Infrared

    CERN Document Server

    Etxaluze, M; Tolls, V; Stark, A A; Gonzalez-Alfonso, E

    2011-01-01

    We analyse the far infrared dust emission from the Galactic Centre region, including the Circumnuclear Disk (CND) and other structures, using Herschel PACS and SPIRE photometric observations. These Herschel data are complemented by unpublished observations by the Infrared Space Observatory Long Wavelength Spectrometer (ISO LWS), which used parallel mode scans to obtain photometric images of the region with a larger beam than Herschel but with a complementary wavelength coverage and more frequent sampling with ten detectors observing at ten different wavelengths in the range from 46 to 180 \\mum, where the emission peaks. We also include data from the MSX at 21.3 \\mum for completeness. We model the combined ISO LWS continuum plus Herschel PACS and SPIRE photometric data toward the central 2 pc in Sgr A*, a region that includes the CND. We find that the FIR spectral energy distribution is best represented by a continuum that is the sum of three greybody curves from dust at temperatures of 90, 44.5, and 23 K. We ...

  9. Detecting pulsars in the Galactic Centre

    Science.gov (United States)

    Rajwade, K. M.; Lorimer, D. R.; Anderson, L. D.

    2017-10-01

    Although high-sensitivity surveys have revealed a number of highly dispersed pulsars in the inner Galaxy, none have so far been found in the Galactic Centre (GC) region, which we define to be within a projected distance of 1 pc from Sgr A*. This null result is surprising given that several independent lines of evidence predict a sizable population of neutron stars in the region. Here, we present a detailed analysis of both the canonical and millisecond pulsar populations in the GC and consider free-free absorption and multipath scattering to be the two main sources of flux density mitigation. We demonstrate that the sensitivity limits of previous surveys are not sufficient to detect GC pulsar population, and investigate the optimum observing frequency for future surveys. Depending on the degree of scattering and free-free absorption in the GC, current surveys constrain the size of the potentially observable population (i.e. those beaming towards us) to be up to 52 canonical pulsars and 10 000 millisecond pulsars. We find that the optimum frequency for future surveys is in the range of 9-13 GHz. We also predict that future deeper surveys with the Square Kilometre array will probe a significant portion of the existing radio pulsar population in the GC.

  10. Detecting pulsars in the Galactic centre

    CERN Document Server

    Rajwade, Kaustubh; Anderson, Loren

    2016-01-01

    Although high-sensitivity surveys have revealed a number of highly dispersed pulsars in the inner Galaxy, none have so far been found in the Galactic centre (GC) region, which we define to be within a projected distance of 1~pc from Sgr~A*. This null result is surprising given that several independent lines of evidence predict a sizeable population of neutron stars in the region. Here, we present a detailed analysis of both the canonical and millisecond pulsar populations in the GC and consider free-free absorption and multi-path scattering to be the two main sources of flux mitigation. We demonstrate the sensitivity limits of previous surveys are not sufficient to detect GC pulsar population, and investigate the optimum observing frequency for future surveys. Depending on the degree of scattering and free-free absorption in the GC, current surveys constrain the size of the potentially observable population (i.e. those beaming towards us) to be up to 50 canonical pulsars and 1430 millisecond pulsars. We find ...

  11. Rockshire Care Centre, Rockshire Road, Ferrybank, Waterford.

    LENUS (Irish Health Repository)

    Bushe, Chris J

    2008-01-01

    BACKGROUND: Weight gain is commonly observed during psychotropic treatments for chronic forms of severe mental illness and is most rapid during the early treatment phases. All formats of behavioural weight intervention programmes have suggested that weight gain can be prevented or reversed in some patients. There is no data on these programmes in acutely unwell inpatients whom may be the major beneficiaries. METHODS: A modular behavioural intervention programme (Solutions for Wellness) used in SMI outpatients since 2002 in Ireland has been adapted for inpatient use. Preliminary data is reported from 5 centres in Ireland. RESULTS: In 47 inpatients the mean weight change was +0.26 kg (SD 2.02) with a median change of 0 kg. Mean follow-up was 23.7 (SD 21.6) days, and median 14 days (range 6-98 days). There was no difference in mean weight change in those patients involved for > 35 days compared with < 35 days (+0.26 kg; 0.25 kg; p = 0.5). Weight loss or maintenance was seen in 70% of patients. CONCLUSION: These preliminary data are supportive of the concept that acutely unwell inpatients with SMI may engage with a behavioural weight programme. Weight change observed contrasts with the significant weight gain often seen in most subjects. Further clinical trials are warranted.

  12. Radio polarimetry of Galactic centre pulsars

    CERN Document Server

    Schnitzeler, D H F M; Ferrière, K; Kramer, M; Lee, K J; Noutsos, A; Shannon, R M

    2016-01-01

    To study the strength and structure of the magnetic field in the Galactic centre (GC) we measured Faraday rotation of the radio emission of pulsars which are seen towards the GC. Three of these pulsars have the largest rotation measures (RMs) observed in any Galactic object with the exception of Sgr A*. Their large dispersion measures, RMs and the large RM variation between these pulsars and other known objects in the GC implies that the pulsars lie in the GC and are not merely seen in projection towards the GC. The large RMs of these pulsars indicate large line-of-sight magnetic field components between ~ 16-33 microgauss; combined with recent model predictions for the strength of the magnetic field in the GC this implies that the large-scale magnetic field has a very small inclination angle with respect to the plane of the sky (~ 12 degrees). Foreground objects like the Radio Arc or possibly an ablated, ionized halo around the molecular cloud G0.11-0.11 could contribute to the large RMs of two of the pulsar...

  13. Science Centres: A Resource for School and Community

    Science.gov (United States)

    Pilo, Miranda; Mantero, Alfonso; Marasco, Antonella

    2011-01-01

    We present a science centre established in Genoa on an agreement between Municipality of Genoa and Department of Physics of University of Genoa. The aim is to offer children, young people and community an opportunity to approach science in a playful way. The centre staffs guide the visitors through the exhibits, attracting their interests towards…

  14. Call Centres in Denmark 2004 - Strategy, HR Practices & Performance

    DEFF Research Database (Denmark)

    Sørensen, Ole H.; El-Salanti, Nadia

    This survey is the first scientifically based benchmarking study of the Danish call centre industry. The main results from the study are based on answers from 128 call centres, which correspond to a response rate of 65%. The Danish study is part of a global project coordinated by researchers at C...

  15. Low-Income Parents' Adult Interactions at Childcare Centres

    Science.gov (United States)

    Reid, Jeanne L.; Martin, Anne; Brooks-Gunn, Jeanne

    2017-01-01

    Little is known about the extent and nature of low-income parents' interactions with other parents and staff at childcare centres, despite the potential for these interactions to provide emotional, informational, and instrumental support. This study interviewed 51 parents at three childcare centres in low-income neighbourhoods in New York City.…

  16. Transitional and Transformational Spaces: Mentoring Young Academics through Writing Centres

    Science.gov (United States)

    Archer, Arlene; Parker, Shabnam

    2016-01-01

    The effectiveness of writing centre interventions on student writing in higher education has been well-documented in academic literacies studies. This paper changes the focus of investigation from student to consultant and, consequently, explores the way in which an academic writing centre can function as a mentoring environment for young…

  17. Opportunity Centred Learning: An Innovation in Enterprise Education?

    Science.gov (United States)

    Rae, David

    2003-01-01

    This paper describes an approach called opportunity centred learning that has been developed by the author and applied in the field of enterprise education. The relationship between opportunity centred learning and existing theory and practice in learning and education is outlined in comparison with problem-based learning and action learning, and…

  18. Mathematics as It Happens: Student-Centred Inquiry Learning

    Science.gov (United States)

    Brough, Chris; Calder, Nigel

    2012-01-01

    This paper examines how mathematical understandings might emerge through student-centred inquiry. Data is drawn from a research project on student-centred curriculum integration (CI) that situated mathematics within authentic problem-solving contexts and involved students in collaboratively constructed curriculum. Participatory action research…

  19. Investigating Teachers' Views of Student-Centred Learning Approach

    Science.gov (United States)

    Seng, Ernest Lim Kok

    2014-01-01

    Conventional learning is based on low levels of students' participation where students are rarely expected to ask questions or to challenge the theories of the academic. A paradigm shift in curriculum has resulted in implementing student-centred learning (SCL) approach, putting students as the centre of the learning process. This mode of…

  20. Mathematics in Student-­Centred Inquiry Learning: Student Engagement

    Science.gov (United States)

    Calder, Nigel

    2013-01-01

    This paper examines how mathematical understandings might be facilitated through student-centred inquiry. Data is drawn from a research project on student-centred inquiry learning that situated mathematics within authentic problem-solving contexts and involved students in a collaboratively constructed curriculum. A contemporary interpretive frame…

  1. The Discharge Coefficient of a Centre-Pivot Roof Window

    DEFF Research Database (Denmark)

    Iqbal, Ahsan; Afshari, Alireza; Nielsen, Peter V.

    2012-01-01

    value of discharge coefficient is used. The constant value of discharge coefficient leads to deceptive airflow estimation in the cases of centre-pivot roof windows. The object of this paper is to study and evaluate the discharge coefficient of the centre pivot roof window. Focus is given...

  2. Using customer contact centres as relationship marketing instruments

    NARCIS (Netherlands)

    Aa, Z. van der; Bloemer, J.M.M.; Henseler, J.

    2015-01-01

    This article investigates whether, to what extent and how customer contact centres influence customer–firm relationships through customer contact centre quality. The proposed model compiles direct and indirect effects of this form of quality on focal relationship marketing constructs, including

  3. Importance of patient centred care for various patient groups.

    NARCIS (Netherlands)

    Rademakers, J.J.D.J.M.; Delnoij, D.M.J.; Boer, D. de

    2010-01-01

    Background: Though patient centred care is a somewhat ‘fuzzy’ concept, in general it is considered as something to strive for. However, preliminary evidence suggests that the importance of elements of patient-centred care (PCC), such as communication, information and shared decision making, may vary

  4. The CERN Control Centre is up and running!

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    The CERN Control Centre (CCC) that combines all the control rooms for the accelerators, the cryogenic system and the technical infrastructure came into operation on 1st February. On 1st February, at 2.00 p.m., Patrick Villeton Pachot started the first Technical Infrastructure shift at the brand new CERN Control Centre.

  5. A cyborg ontology in health care: traversing into the liminal space between technology and person-centred practice.

    Science.gov (United States)

    Lapum, Jennifer; Fredericks, Suzanne; Beanlands, Heather; McCay, Elizabeth; Schwind, Jasna; Romaniuk, Daria

    2012-10-01

    Person-centred practice indubitably seems to be the antithesis of technology. The ostensible polarity of technology and person-centred practice is an easy road to travel down and in their various forms has been probably travelled for decades if not centuries. By forging ahead or enduring these dualisms, we continue to approach and recede, but never encounter the elusive and the liminal space between technology and person-centred practice. Inspired by Haraway's work, we argue that healthcare practitioners who critically consider their cyborg ontology may begin the process to initiate and complicate the liminal and sought after space between technology and person-centred practice. In this paper, we draw upon Haraway's idea that we are all materially and ontologically cyborgs. Cyborgs, the hybridity of machine and human, are part of our social reality and embedded in our everyday existence. By considering our cyborg ontology, we suggest that person-centred practice can be actualized in the contextualized, embodied and relational spaces of technology. It is not a question of espousing technology or person-centred practice. Such dualisms have been historically produced and reproduced over many decades and prevented us from recognizing our own cyborg ontology. Rather, it is salient that we take notice of our own cyborg ontology and how technological, habitual ways of being may prevent (and facilitate) us to recognize the embodied and contextualized experiences of patients. A disruption and engagement with the habitual can ensure we are not governed by technology in our logics and practices of care and can move us to a conscious and critical integration of person-centred practice in the technologized care environments. By acknowledging ourselves as cyborgs, we can recapture and preserve our humanness as caregivers, as well as thrive as we proceed in our technological way of being.

  6. The nitrogen-vacancy colour centre in diamond

    Energy Technology Data Exchange (ETDEWEB)

    Doherty, Marcus W., E-mail: marcus.doherty@anu.edu.au [School of Physics, University of Melbourne, VIC 3010 (Australia); Laser Physics Centre, Research School of Physics and Engineering, Australian National University, ACT 0200 (Australia); Manson, Neil B. [Laser Physics Centre, Research School of Physics and Engineering, Australian National University, ACT 0200 (Australia); Delaney, Paul [School of Mathematics and Physics, Queens University Belfast, Northern Ireland BT7 1NN (United Kingdom); Tyndall National Institute, Lee Maltings, Prospect Row, Cork (Ireland); Jelezko, Fedor [Institut für Quantenoptik, Universität Ulm, Ulm D-89073 (Germany); Wrachtrup, Jörg [3rd Institute of Physics and Research Center SCOPE, University Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart (Germany); Hollenberg, Lloyd C.L. [School of Physics, University of Melbourne, VIC 3010 (Australia)

    2013-07-01

    The nitrogen-vacancy (NV) colour centre in diamond is an important physical system for emergent quantum technologies, including quantum metrology, information processing and communications, as well as for various nanotechnologies, such as biological and sub-diffraction limit imaging, and for tests of entanglement in quantum mechanics. Given this array of existing and potential applications and the almost 50 years of NV research, one would expect that the physics of the centre is well understood, however, the study of the NV centre has proved challenging, with many early assertions now believed false and many remaining issues yet to be resolved. This review represents the first time that the key empirical and ab initio results have been extracted from the extensive NV literature and assembled into one consistent picture of the current understanding of the centre. As a result, the key unresolved issues concerning the NV centre are identified and the possible avenues for their resolution are examined.

  7. Stromal networking: cellular connections in the germinal centre.

    Science.gov (United States)

    Denton, Alice E; Linterman, Michelle A

    2017-03-17

    Secondary lymphoid organs are organized into distinct zones, governed by different types of mesenchymal stromal cells. These stromal cell subsets are critical for the generation of protective humoral immunity because they direct the migration of, and interaction between, multiple immune cell types to form the germinal centre. The germinal centre response generates long-lived antibody-secreting plasma cells and memory B cells which can provide long-term protection against re-infection. Stromal cell subsets mediate this response through control of immune cell trafficking, activation, localization and antigen access within the secondary lymphoid organ. Further, distinct populations of stromal cells underpin the delicate spatial organization of immune cells within the germinal centre. Because of this, the interactions between immune cells and stromal cells in secondary lymphoid organs are fundamental to the germinal centre response. Herein we review how this unique relationship leads to effective germinal centre responses.

  8. An Optimization of Inventory Demand Forecasting in University Healthcare Centre

    Science.gov (United States)

    Bon, A. T.; Ng, T. K.

    2017-01-01

    Healthcare industry becomes an important field for human beings nowadays as it concerns about one’s health. With that, forecasting demand for health services is an important step in managerial decision making for all healthcare organizations. Hence, a case study was conducted in University Health Centre to collect historical demand data of Panadol 650mg for 68 months from January 2009 until August 2014. The aim of the research is to optimize the overall inventory demand through forecasting techniques. Quantitative forecasting or time series forecasting model was used in the case study to forecast future data as a function of past data. Furthermore, the data pattern needs to be identified first before applying the forecasting techniques. Trend is the data pattern and then ten forecasting techniques are applied using Risk Simulator Software. Lastly, the best forecasting techniques will be find out with the least forecasting error. Among the ten forecasting techniques include single moving average, single exponential smoothing, double moving average, double exponential smoothing, regression, Holt-Winter’s additive, Seasonal additive, Holt-Winter’s multiplicative, seasonal multiplicative and Autoregressive Integrated Moving Average (ARIMA). According to the forecasting accuracy measurement, the best forecasting technique is regression analysis.

  9. Everything Is at Stake; Yet Nothing Is at Stake: Exploring Meaning-Making in Game-Centred Approaches

    Science.gov (United States)

    Jones, Ruan; Harvey, Stephen; Kirk, David

    2016-01-01

    While not wishing to cover old ground in articulating the promise or continued promise of phenomenology within the physical education and sports domains, this paper aims to explore the "human" nature of the game-centred approach (GCA) from an existential-phenomenological perspective. In a recent review of literature on the current state…

  10. Assessing public engagement with science in a university primate research centre in a national zoo.

    Directory of Open Access Journals (Sweden)

    Mark T Bowler

    Full Text Available Recent years have seen increasing encouragement by research institutions and funding bodies for scientists to actively engage with the public, who ultimately finance their work. Animal behaviour as a discipline possesses several features, including its inherent accessibility and appeal to the public, that may help it occupy a particularly successful niche within these developments. It has also established a repertoire of quantitative behavioural methodologies that can be used to document the public's responses to engagement initiatives. This kind of assessment is becoming increasingly important considering the enormous effort now being put into public engagement projects, whose effects are more often assumed than demonstrated. Here we report our first attempts to quantify relevant aspects of the behaviour of a sample of the hundreds of thousands of visitors who pass through the 'Living Links to Human Evolution Research Centre' in Edinburgh Zoo. This University research centre actively encourages the public to view ongoing primate research and associated science engagement activities. Focal follows of visitors and scan sampling showed substantial 'dwell times' in the Centre by common zoo standards and the addition of new engagement elements in a second year was accompanied by significantly increased overall dwell times, tripling for the most committed two thirds of visitors. Larger groups of visitors were found to spend more time in the Centre than smaller ones. Viewing live, active science was the most effective activity, shown to be enhanced by novel presentations of carefully constructed explanatory materials. The findings emphasise the importance and potential of zoos as public engagement centres for the biological sciences.

  11. Assessing public engagement with science in a university primate research centre in a national zoo.

    Science.gov (United States)

    Bowler, Mark T; Buchanan-Smith, Hannah M; Whiten, Andrew

    2012-01-01

    Recent years have seen increasing encouragement by research institutions and funding bodies for scientists to actively engage with the public, who ultimately finance their work. Animal behaviour as a discipline possesses several features, including its inherent accessibility and appeal to the public, that may help it occupy a particularly successful niche within these developments. It has also established a repertoire of quantitative behavioural methodologies that can be used to document the public's responses to engagement initiatives. This kind of assessment is becoming increasingly important considering the enormous effort now being put into public engagement projects, whose effects are more often assumed than demonstrated. Here we report our first attempts to quantify relevant aspects of the behaviour of a sample of the hundreds of thousands of visitors who pass through the 'Living Links to Human Evolution Research Centre' in Edinburgh Zoo. This University research centre actively encourages the public to view ongoing primate research and associated science engagement activities. Focal follows of visitors and scan sampling showed substantial 'dwell times' in the Centre by common zoo standards and the addition of new engagement elements in a second year was accompanied by significantly increased overall dwell times, tripling for the most committed two thirds of visitors. Larger groups of visitors were found to spend more time in the Centre than smaller ones. Viewing live, active science was the most effective activity, shown to be enhanced by novel presentations of carefully constructed explanatory materials. The findings emphasise the importance and potential of zoos as public engagement centres for the biological sciences.

  12. The "magic" of tutorial centres in Hong Kong: An analysis of media marketing and pedagogy in a tutorial centre

    Science.gov (United States)

    Koh, Aaron

    2014-12-01

    Why do more than three-quarters of Hong Kong's senior secondary students flock to tutorial centres like moths to light? What is the "magic" that is driving the popularity of the tutorial centre enterprise? Indeed, looking at the ongoing boom of tutorial centres in Hong Kong (there are almost 1,000 of them), it is difficult not to ask these questions. This paper examines the phenomenon of tutorial centres in Hong Kong and seeks to understand what draws students to these centres. Combining theories of marketing semiotics and emotion studies, the author investigates the pivotal role of media marketing in generating the "magic" of tutorial centres, whose advertising strategy includes, for example, a display of billboard posters featuring stylishly-dressed "celebrity teachers". The author reviews some of the literature available on the subject of tutorial centres. In a case study approach, he then maps out the pedagogy he observed in an English tutorial class, seeking heuristic insights into the kind of teaching students in the study were looking for. He argues that part of the "magical" attraction of what are essentially "cram schools" is their formulaic pedagogy of teaching and reinforcing exam skills. Finally, the paper considers the social implications of the tutorial centre industry in terms of media marketing of education and unequal access to tutorial services.

  13. Student-Centred and Teacher-Centred Learning Environment in Pre-Vocational Secondary Education: Psychological Needs, and Motivation

    Science.gov (United States)

    Smit, Karin; de Brabander, Cornelis J.; Martens, Rob L.

    2014-01-01

    In this study the perception of psychological needs and motivation in a student-centred and a teacher-centred learning environment are compared, using Self Determination Theory as a framework. The self-report Intrinsic Motivation Inventory was completed by 230 students (mean age 16.1 years) in pre-vocational secondary education. School records on…

  14. Student-Centred and Teacher-Centred Learning Environment in Pre-Vocational Secondary Education: Psychological Needs, and Motivation

    Science.gov (United States)

    Smit, Karin; de Brabander, Cornelis J.; Martens, Rob L.

    2014-01-01

    In this study the perception of psychological needs and motivation in a student-centred and a teacher-centred learning environment are compared, using Self Determination Theory as a framework. The self-report Intrinsic Motivation Inventory was completed by 230 students (mean age 16.1 years) in pre-vocational secondary education. School records on…

  15. Defining and describing birth centres in the Netherlands - a component study of the Dutch Birth Centre Study

    NARCIS (Netherlands)

    Hermus, M.A.A.; Boesveld, I.C.; Hitzert, M.; Franx, A.; Graaf, J.P. de; Steegers, E.A.P.; Wiegers, T.A.; Pal-de Bruin, K.M. van der

    2017-01-01

    Background: During the last decade, a rapid increase of birth locations for low-risk births, other than conventional obstetric units, has been seen in the Netherlands. Internationally some of such locations are called birth centres. The varying international definitions for birth centres are not

  16. Defining and describing birth centres in the Netherlands - a component study of the Dutch Birth Centre Study.

    NARCIS (Netherlands)

    Hermus, M.A.A.; Boesveld, I.C.; Hilzert, M.; Franx, A.; Graaf, J.P. de; Steegers, E.A.P.; Wiegers, T.A.; Pal-de Bruin, K.M. van der

    2017-01-01

    Background: During the last decade, a rapid increase of birth locations for low-risk births, other than conventional obstetric units, has been seen in the Netherlands. Internationally some of such locations are called birth centres. The varying international definitions for birth centres are not

  17. CLINICAL SPECTRUM OF HYPONATRAEMIA IN TERTIARY CENTRE

    Directory of Open Access Journals (Sweden)

    Suresh Chincholi

    2017-02-01

    Full Text Available BACKGROUND Hyponatraemia is defined as a serum sodium level less than 135 mEq/L. High mortality among the patients of hyponatraemia is secondary to the underlying medical condition. Frequency is high in elderly patients. MATERIALS AND METHODS The study was conducted at a tertiary care centre (Basaveshwar Teaching and General Hospital, Gulbarga, from the period September 2014 to August 2016. These patients were evaluated for the underlying cause of hyponatraemia, which included detailed history and physical examination followed by appropriate laboratory investigations. Patients were followed up till the hyponatraemia was treated or patients were discharged from the hospital. RESULTS 100 patients of hyponatraemia were included in the study. 46% of the patients were asymptomatic. 33% patients had lethargy, 28% patients had postural dizziness and 19% had abnormal behaviour. Overall incidence of hyponatraemia was 4.58% in the hospitalised population, whereas its incidence in ICU patients was 22.4%. Twelve patients of symptomatic severe hyponatraemia were treated with hypertonic saline infusion, 25% patients were given loop diuretics with oral supplementation of sodium chloride for free water excretion in SIADH cases and in patients with hypervolaemia, hyponatraemia, fluid restriction was advised to 44 patients, oral supplementation of sodium chloride was given in 36 patients and 64 patients received normal saline. 9 patients included in the study died, 5 of which had advanced cirrhosis of liver as underlying cause. One patient developed Osmotic Demyelination Syndrome (ODS. CONCLUSION The possible cause of hyponatraemia should always be sought as outcome in severe hyponatraemia is governed by aetiology, and not by the serum sodium level. Treatment of severe symptomatic hyponatraemia with hypertonic saline is safe if recommendation for the rate of correction of hyponatraemia is strictly followed.

  18. Interprofessional Resource Centre: a knowledge translation strategy

    Directory of Open Access Journals (Sweden)

    Christine Patterson

    2011-01-01

    Full Text Available Christine Patterson1,2, Julie Vohra1, David Price3, Gladys Peachey1, Heather Arthur1,4, Patricia Ellis1, Rob Mariani5, Paul Dymel5, Ellen Spencer5, Kevin Timms5, Ellis Westwood51School of Nursing, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; 2Ontario Primary Health Care Nurse Practitioner Program, McMaster University, Hamilton, ON, Canada; 3Department of Family Medicine, McMaster University, Hamilton, ON, Canada; 4Heart and Stroke Foundation of Ontario/Michael G. DeGroote Endowed Chair in Cardiovascular Nursing Research, McMaster University, Hamilton, ON, Canada; 5Ascentum, Ottawa, ON, CanadaAbstract: The Interprofessional Resource Centre (IRC was based on an extensive literature search and a provincial consultative process that involved administrators, health care providers, educators, preceptors, and alternative and complementary health care providers from different disciplines. Information from the literature review was synthesized into a logic model that served as a preliminary outline for the IRC to be further developed during the stakeholder consultation. The findings from the literature were triangulated with the opinions of different groups of key stakeholders who participated in three different methods of data collection: 1 a large-scale deliberative survey, 2 an in-person dialogue, and 3 targeted questionnaires. The result of this process was an online tool that presents information on what needs to be considered when planning interprofessional practice and education within an organization with the purpose of: 1 building capacity within agencies for interprofessional, collaborative practice; 2 providing preceptors with educational strategies to develop interprofessional competencies in their students; 3 promoting the use of technology as a strategy for knowledge transfer within the agencies and between educational institutions; and 4 developing an evaluation plan to measure interprofessional practice and

  19. Hillary Clinton impressed by the Centre's work.

    Science.gov (United States)

    1995-01-01

    In April 1994, US First Lady Hillary Rodham Clinton, her daughter Chelsea, the Bangladesh Minister for Women and Children's Affairs, and the US Ambassador to Bangladesh visited the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B). The First Lady remarked that ICDDR,B's research programs on health and family planning have many important lessons for the developing and developed regions alike. She noted the development successes in Bangladesh that can be applied in the US and other countries: the Grameen Bank, oral rehydration solution (ORS), and the community outreach programs for health and family planning services. The First Lady was especially interested in ORS and its cost-effectiveness. Most of the 220,000 children hospitalized each year in the US for severe gastrointestinal illness are treated with expensive intravenous (IV) drips (average cost = $2300), while a few ORS packets would be a small fraction of the cost. The average cost of treatment per patient at ICDDR,B was only $12. Patients receive care free of charge. Less than 0.6% of the patients die. The previous year, a USAID administrator asked ICDDR,B for its expertise in fighting cholera at the Rwandan refugee camps in Goma, Zaire. ICDDR,B staff developed diagnostic antisera for the new cholera strain responsible for the epidemic in the Americas, described its pathophysiology, and established its mode of transmission in surface waters. ICDDR,B also provides technical support to the national family planning and maternal and child health programs. In the Matlab, ICDDR,B's work has contributed to a high contraceptive prevalence rate of more than 64% among poor and largely illiterate persons.

  20. Enabling occupation: occupation-based and client centred practice in Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Tatiana Barcelos Pontes

    2016-04-01

    Full Text Available Occupational therapists have always been dedicated to the human occupation study, however the client hasn’t always been seen as an occupational being, with needs, interests and individual goals. The concern for our clients’ engagement in occupation, rather than the acquisition or restoration of performance components, together with the gradual modification of the concept of occupation from work-related activities to purposeful human activity, requires a broadening of our scope of practice. The most current theories related to occupational therapy practice have highlightes the use of client centered and occupational based practices. In occupation-based, client-centred practice the client participates actively in negotiating goals, and client occupational goals are given priority and are placed at the centre of assessment, intervention and outcomes. There are numerous evidences in the literature with significantly positive results supporting these approaches. These approaches are based on the premises that goals and objectives of interventions should be focused in occupation and significant activities to the client and reflect the occupational therapy core values: an occupational-centred perspective that respects client’s choices, goals and values, promoting and supporting the engagement on meaningful activities.

  1. Based on NUREG/CR-7007 Guidelines for AP1000 Device Interface Module (CIM) and Diversiifcation Drive System (DAS) Diversity%基于NUREG/CR-7007导则的AP1000设备接口模块(CIM)和多样化驱动系统(DAS)多样性分析

    Institute of Scientific and Technical Information of China (English)

    张丰平

    2016-01-01

    AP1000核电厂采用多样化驱动系统(DAS)作为反应堆保护系统的多样性后备,两者之间的多样化程度对共模故障影响重大。本文基于NUREG/CR-7007导则对设备接口模块(CIM)和多样化驱动系统进行多样性分析和计算,确认满足NUREG/CR-7007的要求,为多样化系统的设计提供参考。%AP1000 nuclear power plant uses a Diverse Actuation System (DAS) as the diversity backup for the reactor protection system, the diversity between them is very important to the common cause failure (CCF). This paper performs a diversity evaluation of the Component Interface Module (CIM) and Diversity Actuation System (DAS) to verify it meet the requirement of NUREG/CR-7007 Guidance and provide reference for I&C system design.

  2. Reference values for the geometric centre analysis of colonic transit measurements with 111indium-labelled diethylenetriamine penta-acetic acid

    DEFF Research Database (Denmark)

    Madsen, Jan Lysgård; Fuglsang, Stefan; Graff, Jesper

    2003-01-01

    The geometric centre analysis is often used for evaluating colonic transit data obtained by scintigraphy after oral intake of 111indium-labelled diethylenetriamine penta-acetic acid (111In-DTPA). The purpose of this study was to establish reference values for the geometric centre analysis in adult...... humans. Forty-eight healthy volunteers (24 women, 24 men) who were equally distributed among three age groups (young, middle-aged, elderly) were studied. In all subjects the geometric centre of radioactivity in the colon was calculated from abdominal gamma camera images acquired 24, 48, 72, and 96 h...

  3. Bodies or organisms? Medical encounter as a control apparatus at a primary care centre in Barcelona

    Directory of Open Access Journals (Sweden)

    Alejandro Zaballos Samper

    2013-07-01

    Full Text Available Medical practice is driven by technology, discourses, and knowledge about health and illness. This has resulted in its gaining a dominating position in power relations achieved by means of diagnosis, medicalization, and habit and conduct creation and maintenance. Interaction at primary care centres is built on mainstream biomedical views of both the medical discourse and the social practices related to health, illness and the human body. Moreover, it is also rooted on the ideologies conveyed by those social concepts, which in turn, permeate interaction all through with power relations. The present paper takes ethnographic data and in-depth interviews as a departing point to analyse how diagnosis, medicalization, and biopolicies for health prevention and improvement carried out in primary care centres in Barcelona make up a control apparatus. Furthermore, this essay also explores how the apparatus is developed in the medical encounter and turns the body into an organism.

  4. Pseudomonas aeruginosa antibiotic resistance in Australian cystic fibrosis centres.

    Science.gov (United States)

    Smith, Daniel J; Ramsay, Kay A; Yerkovich, Stephanie T; Reid, David W; Wainwright, Claire E; Grimwood, Keith; Bell, Scott C; Kidd, Timothy J

    2016-02-01

    In cystic fibrosis (CF), chronic Pseudomonas aeruginosa infection is associated with increased morbidity, antibiotic treatments and mortality. By linking Australian CF registry data with a national microbiological data set, we examined the association between where treatment was delivered, its intensity and P. aeruginosa antibiotic resistance. Sputa were collected from paediatric and adult CF patients attending 18 Australian CF centres. P. aeruginosa antibiotic susceptibilities determined by local laboratories were correlated with clinical characteristics, treatment intensity and infection with strains commonly shared among Australian CF patients. Between-centre differences in treatment and antibiotic resistance were also compared. Large variations in antibiotic usage, maintenance treatment practices and multi-antibiotic resistant P. aeruginosa (MARPA) prevalence exist between Australian CF centres, although the overall proportions of MARPA isolates were similar in paediatric and adult centres (31% vs 35%, P = 0.29). Among paediatric centres, MARPA correlated with intravenous antibiotic usage and the Australian state where treatment was delivered, while azithromycin, reduced lung function and treating state predicted intravenous antibiotic usage. In adult centres, body mass index (BMI) and treating state were associated with MARPA, while intravenous antibiotic use was predicted by gender, BMI, dornase-alpha, azithromycin, lung function and treating state. In adults, P. aeruginosa strains AUST-01 and AUST-02 independently predicted intravenous antibiotic usage. Increased treatment intensity in paediatric centres and the Australian state where treatment was received are both associated with greater risk of MARPA, but not worse clinical outcomes. © 2015 Asian Pacific Society of Respirology.

  5. Waste management in primary healthcare centres of Iran.

    Science.gov (United States)

    Mesdaghinia, Alireza; Naddafi, Kazem; Mahvi, Amir Hossein; Saeedi, Reza

    2009-06-01

    The waste management practices in primary healthcare centres of Iran were investigated in the present study. A total of 120 primary healthcare centres located across the country were selected using the cluster sampling method and the current situation of healthcare waste management was determined through field investigation. The quantities of solid waste and wastewater generation per outpatient were found to be 60 g outpatient(-1) day(-1) and 26 L outpatient(-1) day(-1), respectively. In all of the facilities, sharp objects were separated almost completely, but separation of other types of hazardous healthcare solid waste was only done in 25% of the centres. The separated hazardous solid waste materials were treated by incineration, temporary incineration and open burning methods in 32.5, 8.3 and 42.5% of the healthcare centres, respectively. In 16.7% of the centres the hazardous solid wastes were disposed of without any treatment. These results indicate that the management of waste materials in primary healthcare centres in Iran faced some problems. Staff training and awareness, separation of healthcare solid waste, establishment of the autoclave method for healthcare solid waste treatment and construction of septic tanks and disinfection units in the centres that were without access to a sewer system are the major measures that are suggested for improvement of the waste management practices.

  6. Central Computer IMS Processing System (CIMS).

    Science.gov (United States)

    Wolfe, Howard

    As part of the IMS Version 3 tryout in 1971-72, software was developed to enable data submitted by IMS users to be transmitted to the central computer, which acted on the data to create IMS reports and to update the Pupil Data Base with criterion exercise and class roster information. The program logic is described, and the subroutines and…

  7. Career Information in the mathematical sciences (CIMS)

    Energy Technology Data Exchange (ETDEWEB)

    Sterrett, A.

    1993-05-01

    In November of 1992, a CBMS Steering Committee for Career Information was appointed by the CBMS Council. An informal meeting of those members in attendance at the Annual Meeting of the MAA and the AMS was held in January, 1993. The first meeting was held on May 1, 2 in Washington, DC in conjunction with CBMS Council meeting. Information on existing career materials was provided to the Council at that time and Council reactions were obtained. These reactions, along with reviews of material by students, faculty members and counselors, were used by the Steering Committee to plan specific activities for the next 6--18 months. Three initiatives were given high priority: To produce and widely disseminate an annotated bibliography of career information relevant to the mathematical sciences; to remedy the lack of messages to junior high school students, parents, teachers and counselors on the importance of mathematics in finding good jobs in a technological society; and to encourage women and minorities to take all the mathematics that they can and to consider careers in which mathematics plays an important role.

  8. Role of logistics centres in national logistics system

    Directory of Open Access Journals (Sweden)

    2010-06-01

    Full Text Available This article presents a division of logistics centres according to various criteria and specifies their role in a national logistics system. It provides a classification of the main logistics network nodes. It also describes those features of logistics centres that have an impact on zoning development of towns and regions. The current situation in the national logistics system has been presented here against theoretical analyses and also a concept for the development of a logistics centre network in Poland has been formulated.

  9. Gravitational centre of mass and localization of dark energy

    CERN Document Server

    Maluf, J W

    2015-01-01

    We analyse the expression for the centre of mass density of the gravitational field in the context of the teleparallel equivalent of general relativity. The purpose is to investigate the localization of dark energy in the three-dimensional space, induced by a cosmological constant in a simple Schwarzschild-de Sitter space-time. We also investigate the gravitational centre of mass density in a particular model of dark matter, in the space-time of a point massive particle and in an arbitrary space-time with axial symmetry. The results are plausible, and lead to the notion of gravitational centre of mass distribution function.

  10. The experience of work in a call centre environment

    Directory of Open Access Journals (Sweden)

    Sanet Hauptfleisch

    2006-02-01

    Full Text Available This qualitative research study explored the work experience in a call centre environment in an information technology call centre based in South Africa, which service foreign customers exclusively. Three data collection methods were used, namely narratives, in-depth interviews with call centre consultants, and observation. Following a grounded theory approach, four themes were elicited, namely the perceptions of team members, uncertainty created by a constantly changing environment, perceived distances due to management practices, and depersonalisation experienced while actually dealing with customers. In addition to this, the reported impact of these themes on work performance was explored and compared to existing research.

  11. Negotiating active ageing at a Danish activity centre

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    and practices active ageing. The paper uses an activity centre in Copenhagen as its site of negotiation. Methods: These questions have been explored with the use of ethnographic fieldwork and through a documentary study. The ethnographic fieldwork has been conducted at an activity centre with 4 months...... of participatory observation in 2011 and 2012, as well as 11 semi-structured, in-depth interviews with users of the centre. 4 of these users have been followed around during everyday activities such as doing groceries, picking up grandchildren, etc. The documentary study consists of documents and statements...

  12. Visualization in a Climate Computing Centre

    Science.gov (United States)

    Meier-Fleischer, Karin; Röber, Niklas; Böttinger, Michael

    2014-05-01

    Today, the extensive numerical simulations of climate models require elaborate visualization for understanding and communicating the results. Typical data sets of climate models are 3-dimensional, multivariate and time dependent, and can hence be very large. Interactive visual data analysis improves and accelerates the comprehension of these vast amounts of data. At DKRZ, the German Climate Computing Centre, a central high end visualization server, various domain specific visualization applications, and a remote 3D rendering solution enable users to interactively visualize their extensive model results right at their desktops. The DKRZ's visualization server is a heterogeneous Linux cluster, currently consisting of 10 state of the art visualization nodes equipped with 96 -256 GB RAM and high end NVidia GPUs. Since the parallel file system of the DKRZ's supercomputer is directly mounted over a powerful network, the model data can directly be analyzed and visualized. VirtualGL and TurboVNC are used for utilizing the server's GPUs for 3D rendering, while the TurboVNC client on the user's local computer continuously displays the resulting video stream. By using this central visualization server instead of a local computer, three main benefits are achieved: Time consuming transfers of large data sets from the supercomputer to the local computer are not needed. The hardware of the user's local workstation doesn't need to be powerful, no expensive GPU is required. Users don't have to install or buy visualization software. On the visualization server, a wide range of visualization software is installed. Avizo Green, a powerful commercial software customized for interactive 3D visualization of climate model data, is available, as well as SimVis and ParaView, which focus more on an exploratory visualization of data. SimVis and ParaView provide techniques like Linking & Brushing to emphasize or de-emphasize portions of the data. Furthermore, some domain specific 2D graphics

  13. CWTC business plan; Wind turbine component centre

    Energy Technology Data Exchange (ETDEWEB)

    Hjuler Jensen, P.; Hillestroem, A.; Markou, H.; Berring, P.; Friis, P.

    2011-04-15

    This report presents the Business Plan for the establishment of the Wind Turbine Component Centre (CWTC) to meet the objectives of performing theoretical research and experimental testing. The core idea of a CWTC is to support the Danish wind energy industry and research activities at the component level improving the competitive advantage of that industry. The CWTC will in itself operate its activities, including access to test and experimental facilities, on a semi commercial basis. The business model for the CWTC presented is based on revenues coming from component manufacturers as well as research grants, and will include membership fees as well as hourly payment and larger projects where payment is a limited project sum. The presented roadmap model clarifies the development path towards a fully developed CWTC, which will cover test of all important components along the drive-train as well as offering a comprehensive systematic understanding of the entire drive-train. The CWTC will over time market and sell its products and services on a global scale, but first and foremost the CWTC is established to support and strengthen the Danish wind energy industry and specifically the Danish sub suppliers to the Danish wind turbine industry and also the Danish research establishments. The presented organizational structure reflects that there are certain functions that are separated from the operations and it also reflects that scientific staffing are hired in on a project basis. Machine operators will be hired in on a permanent basis. The breakdown of the cost for running the rig, both for R and D and commercial projects is presented. The income from the other activities is calculated based on the cost for the research staff, both for R and D activities and commercial. In the first year the income will be 100% from R and D activities, which is the cost for the staff to set-up the test-rig, the guidelines and test procedures, and partly for running the rig. Within 3

  14. An enhanced Planetary Radar Operating Centre (PROC)

    Science.gov (United States)

    Catallo, C.

    2010-12-01

    Planetary exploration by means of radar systems, mainly using GPRs is an important role of Italy and numerous scientific international space programs are carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Three experiments under Italian leadership ( designed and manufactured by the Italian industry) provided by ASI within a NASA/ESA/ASI joint venture framework are successfully operating: MARSIS on-board MEX, SHARAD on-board MRO and CASSINI Radar on-board Cassini spacecraft: the missions have been further extended . Three dedicated operational centers, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD are operating from the missions beginning to support all the scientific communities, institutional customers and experiment teams operation Each center is dedicated to a single instrument management and control, data processing and distribution and even if they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). In order to harmonize operations either from logistics point of view and from HW/SW capabilities point of view PROC is designed and developed for offering improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. PROC is, therefore, conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs, such as Europa-Jupiter System Mission (EJSM) The paper describes how the new PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation aiding scientists to increase their knowledge in the field of surface

  15. Target preparation at the ANTARES AMS Centre

    Energy Technology Data Exchange (ETDEWEB)

    Jacobsen, G.E.; Hua, Q.; Fink, D.; Hotchkis, M.A.C.; Lawson, E.M. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1996-12-31

    The Antares Accelerator Mass Spectroscopy Centre at ANSTO has two chemistry labs dedicated to preparing targets for measurement. Target preparation encompasses a variety of activities ranging from the curation of incoming samples to the numerous steps involved in the purification and processing of dissimilar samples. One of the two laboratories is set up for the physical and chemical pretreatment of {sup 14}C samples. Treatments include cleaning by sonification, sorting, grinding and sieving, and chemical treatments such as the standard AAA treatment, and solvent extraction. Combustion and graphitization are also carried out in this laboratory. The second laboratory is a clean room and is dedicated to the combustion, hydrolysis and graphitization of {sup 14}C samples as well as the process of the targets for the other isotopes. Combustion is achieved by heating the sample to 900 deg C in the presence of CuO, the resulting gas is purified by passing over Ag and Cu wire at 600 deg C. Graphitization is carried out by reducing the CO{sub 2} with an iron catalyst (600 deg C) in the presence of zinc (400 deg C) and a small amount of hydrogen. Samples such as charcoal, shell bone, wood, sediment, seawater and groundwater, containing 0.3-1 mg or more of original carbon, are processed routinely for radiocarbon analysis. The current {sup 14}C chemistry background for 1 mg carbon is {approx} 0.3 percent of modern carbon (pMC) enabling us to date materials up to 45 000 BP. Samples of 0.5 - 3 mg carbon or more are routinely performed with a precision < 1% At present, procedures are being tested for the treatment of samples containing a minimum of 20 {mu}g original carbon. Such small samples sre more likely to be affected by contamination with modern carbon. These laboratories are also being expanded to cater for the processing of a variety of samples for the measurement of other isotopes, ie {sup 129}I, {sup 10}Be, {sup 36}CI and {sup 26}Al. Initial tests for the extraction of

  16. Upgrade Opportunities for Buildings in City Centres

    Directory of Open Access Journals (Sweden)

    Silva M.

    2012-10-01

    Full Text Available This proposal focus on the potential of the existing buildings upgrade process in achieving the 20-20-20 goals, as these are the biggest energy consumers, the most significant built area and the better placed buildings within our cities. These buildings frequently lack basic maintenance and need intervention, but include within themselves a vast amount of incorporated energy and centuries of construction knowledge. Beyond the advantages that may result from re-attracting people back into the city centre, upgrading these existing buildings can also have positive bounce-back effect on the reduction of the energy needs related to transportation, as demonstrated in studies that alert to the impact of the building sprawl in the total energy use. As “buildings account for 40 % of total energy consumption in the Union”, the better performance of this sector has a significant role, remembering that “these requirements shall take account of general indoor climate conditions, in order to avoid possible negative effects such as inadequate ventilation, as well as local conditions and the designated function and the age of the building” [1]. The importance of “upgrading” the existing buildings resides on the fact that new buildings represent only approximately 1 or 2% of the total usable area, an estimate that is bound to decrease due to the current construction crisis. While the recent buildings tend to be more efficient, the numerous existing buildings are important stakeholders due to their massive consumptions and incorporated energy. The ongoing Annex 56 on “Energy & Greenhouse Gas Optimized Building Renovation” assumes that “Current standards do not respond effectively to the numerous constraints imposed by existing buildings and in many cases, the requirements result in very expensive measures and complex procedures, seldom accepted by occupants, owners or developers. It is then urgent for the new standards to respond to these

  17. The Sir Anthony Mamo Oncology Centre

    OpenAIRE

    2015-01-01

    In 2009, the development of a medical brief, effectively detailing the specifications for a purpose-built oncology hospital and including the medical equipment and human resources required, was commenced. Robust engagement by the relevant stakeholders, many of which hailed from the extant Sir Paul Boffa Hospital, ensured a very relevant proposal. The project (ERDF 196), led by the Foundation for Medical Sciences, was subsequently approved for partial funding through Europ...

  18. Estimation of the Centre of Mass From Motion Capture and Force Plate Recordings: A Study on the Elderly

    Directory of Open Access Journals (Sweden)

    S. Cotton

    2011-01-01

    Full Text Available The estimation of the centre of mass position in humans is usually based on biomechanical models developed from anthropometric tables. This method can potentially introduce errors in studies involving elderly people, since the ageing process is typically associated with a modification of the distribution of the body mass. In this paper, an alternative technique is proposed, and evaluated with an experimental study on 9 elderly volunteers. The technique is based on a virtual chain, identified from experimental data and locating the subject's centre of mass. Its configuration defines the location of the centre of mass, and is a function of the anatomical joint angles measured on the subject. This method is a valuable investigation tool in the field of geronto-technology, since it overcomes some of the problems encountered with other CoM estimation methods.

  19. role of stakeholders at cape coast ppag youth centre

    African Journals Online (AJOL)

    Elizabeth

    (PPAG) youth centre impacted positively on the youth behaviour and performance at the ... Family Life Education (FLE) service, like all other services, is ..... educational psychology principles of adolescent stress and storm, which posit that ...

  20. Situational Analysis on Infection Control Practices in DOTS Centres ...

    African Journals Online (AJOL)

    Situational Analysis on Infection Control Practices in DOTS Centres in 7 Local Government Areas in Abia State. ... Open Access DOWNLOAD FULL TEXT ... Instruments used for data collection were the infection control checklist (modified with ...

  1. EFFECT OF V C NCY ON SHOPPING CENTRES' INVESTMENT ...

    African Journals Online (AJOL)

    USER

    2015-01-12

    Jan 12, 2015 ... Keywords: Investment, Rental Returns, Shopping centre, Vacancy Rate. Introduction .... costs, heterogeneity of the housing stock, tenant mobility ..... Beta. (Constant). 3668.427. 333.986. 10.984 .000. Vacancy Rate. -41.569.

  2. The Visual Advice Centre, Eindhoven, The Netherlands. An intervenient evaluation.

    Science.gov (United States)

    Neve, J J; Korten, W E; Jorritsma, F F; Kinds, G F; Legein, C P

    1992-01-01

    On referral by ophthalmologists, the Visual Advice Centre provides the partially sighted with advice and prescriptions for illumination and visual aids. In this paper the multidisciplinary structure of the centre is presented and the results obtained in the first 18 months of its existence are discussed. Two hundred and ninety-eight patients were referred to the centre in this period. The majority of these patients (79.2%) were older than 60 years. The main cause of visual impairment was macular disease (45.3% of the patients). An interesting finding is that, although reading is an important need, reading problems only constituted 35.9% of the total number of demands for help. From an inquiry into the situation of 125 patients 6 months after prescription, it appears that more than 90% of the aids prescribed are used regularly. The conclusion is drawn that patients referred to the Visual Advice Centre benefit from the multi-disciplinary approach to their problems.

  3. Attitudes towards aloneness during adolescence : A Person-Centred Approach

    NARCIS (Netherlands)

    Teppers, E.; Luyckx, K.; Vanhalst, J.; Klimstra, T.A.; Goossens, L.

    2014-01-01

    Benefits and disadvantages of solitude for adolescents are often highlighted. However, research focusing on adolescents' attitudes towards solitude and their associations with such disadvantages or benefits is rather limited. The present study provides a person-centred perspective on the

  4. Dietary management practices in phenylketonuria across European centres

    DEFF Research Database (Denmark)

    Ahring, Kirsten; Bélanger-Quintana, Amaya; Dokoupil, Katharina

    2009-01-01

    BACKGROUND: Dietary phenylalanine restriction is the cornerstone of phenylketonuria (PKU) management. However, there are no European consensus guidelines for its optimal dietary care. METHODS: Detailed information on the routine dietary management of PKU was obtained from 10 European centres using...... and nutritionists varied widely; in some centres dietitians were responsible for managing the diet, while in others this was performed by a physician. There were marked differences in target blood phenylalanine concentrations, the dosages of protein substitutes, systems for allocating daily phenylalanine allowance......, and the definition of foods that could be eaten without restriction ('free foods'). Eighty percent (n=8/10) of centres encouraged breastfeeding together with protein substitute in infants with PKU. CONCLUSIONS: Important differences exist among centres across Europe in the dietary management of PKU, and in support...

  5. Nano-engineered pinning centres in YBCO superconducting films

    Science.gov (United States)

    Crisan, A.; Dang, V. S.; Mikheenko, P.

    2017-02-01

    For practical applications of superconducting materials in applied magnetic fields, artificial pinning centres in addition to natural ones are required to oppose the Lorentz force. These pinning centres are actually various types of defects in the superconductor matrix. The pinning centres can be categorised on their dimension (volume, surface or point) and on their character (normal cores or Δκ cores). Different samples have been produced by Pulsed Laser Deposition, with various thicknesses, temperatures and nanostructured additions to the superconducting matrix. They have been characterized by SQUID Magnetic Properties Measurement System and Physical Properties Measurement System, as well as by Transmission Electron Microscopy (TEM). Correlations between pinning architecture, TEM images, and critical currents at various fields and field orientations will be shown for a large number of YBa2Cu3Ox films with various types and architectures of artificial pinning centres.

  6. Dietary management practices in phenylketonuria across European centres

    NARCIS (Netherlands)

    Ahring, Kirsten; Belanger-Quintana, Amaya; Dokoupil, Katharina; Ozel, Hulya Gokmen; Lammardo, Anna Maria; MacDonald, Anita; Motzfeldt, Kristina; Nowacka, Maria; van Rijn, Margreet; Robert, M.

    Background: Dietary phenylalanine restriction is the cornerstone of phenylketonuria (PKU) management. However, there are no European consensus guidelines for its optimal dietary care. Methods: Detailed information on the routine dietary management of PKU was obtained from 10 European centres using

  7. Cyber Capability Development Centre (CCDC): Proposed Governance Model

    Science.gov (United States)

    2013-12-01

    Canada. Contract Report DRDC-RDDC-2014-C170 December 2013 Cyber Capability Development Centre ( CCDC ) Proposed governance model Douglas...13 ii Table of Figures Figure 1: CCDC organization and infrastructure

  8. CSIR National Laser Centre develops a high speed OCT system

    CSIR Research Space (South Africa)

    Sharma, Ameeth

    2016-11-01

    Full Text Available impact areas and applications include polymer characterisation, surface and thin-film characterisation and biometrics. The National laser Centre has developed a high speed, large area optical coherence tomography (OCT) prototype for fingerprint scanning...

  9. Students' perceptions on teacher - centred methods in teaching ...

    African Journals Online (AJOL)

    Students' perceptions on teacher - centred methods in teaching classification in ... lecture method in classification because the subject is practically oriented ... to attend Nigeria Library Associ ation (NLA)annual classification conference .

  10. Inequality in heritage centres: Analysing the reality in Mexican cities

    National Research Council Canada - National Science Library

    Marina DE LA TORRE; David NAVARRETE

    2016-01-01

    .... With a multidisciplinary approach, we develop a theoretical analysis that allows us to understand the new condition of Mexican historical centres caused by the challenges imposed by becoming a World Heritage Site...

  11. Enantiomeric resolution of multiple chiral centres racemates by capillary electrophoresis.

    Science.gov (United States)

    Ali, Imran; Suhail, Mohd; Al-Othman, Zeid A; Alwarthan, Abdulrahman; Aboul-Enein, Hassan Y

    2016-05-01

    Enantiomeric resolution of multichiral centre racemates is an important area as some multichiral centre racemates are of great medicinal importance. However, enantioseparation of such types of racemates is a challenging task. Amongst many analytical techniques, capillary electrophoresis is a powerful technique and may be used to resolve such racemates. Only few papers are available describing enantiomeric resolution of such racemates. Therefore, efforts have been made to describe the enantiomeric resolution of multichiral centre racemates by capillary electrophoresis. This article discusses the importance of multichiral racemates, the need for capillary electrophoresis in enantiomeric resolution and chiral resolution of multichiral centre racemates using various chiral selectors. Further, attempts have been made to discuss the future challenges and prospects of enantiomeric resolution of multichiral racemates. The various chiral selectors used for the purpose are chiral crown ether, cyclodextrins, polysaccharides, macrocyclic glycopeptide antibiotics and ligand exchange.

  12. Protein-lipid interactions in the purple bacterial reaction centre.

    Science.gov (United States)

    Jones, Michael R; Fyfe, Paul K; Roszak, Aleksander W; Isaacs, Neil W; Cogdell, Richard J

    2002-10-11

    The purple bacterial reaction centre uses the energy of sunlight to power energy-requiring reactions such as the synthesis of ATP. During the last 20 years, a combination of X-ray crystallography, spectroscopy and mutagenesis has provided a detailed insight into the mechanism of light energy transduction in the bacterial reaction centre. In recent years, structural techniques including X-ray crystallography and neutron scattering have also been used to examine the environment of the reaction centre. This mini-review focuses on recent studies of the surface of the reaction centre, and briefly discusses the importance of the specific protein-lipid interactions that have been resolved for integral membrane proteins.

  13. Centre National d'enseignement à distance (CNED

    Directory of Open Access Journals (Sweden)

    Stefania Manca

    1996-01-01

    Full Text Available Presentation of the Centre National d'Enseignement a Distance "(CNED in France, a public institution with the aim of providing and promoting distance learning, especially through the modern communication techniques.

  14. DST-funded information security centre of competence

    CSIR Research Space (South Africa)

    Taute, B

    2009-06-06

    Full Text Available activities), the Information Security Centre of Competence Concept, the identification of three broad market opportunities, and outcomes and governance of the concepts. The worldwide information infrastructure is increasingly under attack by cyber criminals...

  15. towards participant-centred resource development for environmental ...

    African Journals Online (AJOL)

    sponsors alike, to find brand new and beautifully filed materials in media centres, ... Some research has, however, been successful in getting to grips with a less .... used to define a research, implementation and development strategy for Action.

  16. Dynamic analysis of house price diffusion across Asian financial centres

    OpenAIRE

    Nanda, Anupam; Yeh, Jia-Huey

    2012-01-01

    The aim of this paper is to explore effects of macroeconomic variables on house prices and also, the lead-lag relationships of real estate markets to examine house price diffusion across Asian financial centres. The analysis is based on the Global Vector Auto-Regression (GVAR) model estimated using quarterly data for six Asian financial centres (Hong Kong, Tokyo, Seoul, Singapore, Taipei and Bangkok) from 1991Q1 to 2011Q2. The empirical results indicate that the global economic conditions pla...

  17. Student centred teaching methods in a Chinese setting.

    Science.gov (United States)

    Clarke, Janice

    2010-01-01

    This paper offers a discussion about using Western, student centred teaching methods with Chinese student nurses. There is increasing interest from Chinese nurse educators in student centred learning and an increase in partnerships between Chinese and Western universities. This paper suggests that the assumption that Western teaching methods are superior is now questioned and transferring Western style teaching to China requires a high degree of cultural sensitivity.

  18. How to do a person-centred eye health consultation

    Directory of Open Access Journals (Sweden)

    Renée du Toit

    2015-09-01

    Full Text Available The care we give should focus on our patients – their needs, beliefs, and preferences – and not just on their disease. This is known as patient-centred care. We can take this idea further and talk about person-centred care, which reminds us that we should be concerned with the whole person – and their life – when they are outside of the clinic too, not just when they are in front of us.

  19. Appendix to dialysis centre guidelines: recommendations for the relationship between outpatient haemodialysis centres and reference hospitals. Opinions from the Outpatient Dialysis Group. Grupo de Trabajo de Hemodiálisis Extrahospitalaria.

    Science.gov (United States)

    Berdud, I; Arenas, M D; Bernat, A; Ramos, R; Blanco, A

    2011-01-01

    The different clinical guidelines backed by the Spanish Society of Nephrology (SEN) attempt to homogenise the monitoring of renal patients. However, this effort to homogenise treatment has been obstructed in the case of renal replacement therapy patients on haemodialysis due to, among other reasons, the existence of several different dialysis providers, with private centres located in many cities, each with their own reference hospitals and different criteria for treatment based on the existing outsourcing services agreements with the public health service, which also differ between regions. A good relationship between a private dialysis centre and its reference hospital would lead to equal treatment for all dialysis patients, at least at that particular town. The SEN, through the efforts of the Grupo de Trabajo de Hemodiálisis Extrahospitalaria (Outpatient Haemodialysis Group), has prioritised a close relationship and good communication between reference hospitals and dialysis centres in order to guarantee proper continuity of the health care given to these patients. Conditions for referring patients from one centre to another. A patient that starts a haemodialysis programme should be referred from a reference hospital with a definitive vascular access for optimising treatment, with a full report updated within 24-48 hours before the transferral, including essential information for providing proper nephrological treatment: primary pathology, recent viral serology (including hepatitis B and C virus [HBV and HCV] and human immunodeficiency virus [HIV]), parameters for anaemia and calcium-phosphorus metabolism, and ions, date of the first session of dialysis, and the number and dates of blood transfusions received. Furthermore, patients referred from the dialysis centre to the hospital, whether for programmed visits or emergency hospitalisation, should be accompanied by an updated report indicating the primary diagnoses, recent events, viral serology and laboratory

  20. Communication training for centre-based carers of children with severe or profound disabilities in the Western Cape, South Africa

    Directory of Open Access Journals (Sweden)

    Martha Geiger

    2012-05-01

    Full Text Available The purpose of this paper is to provide a preliminary, qualitative review of an approach to training centre-based carers in supporting basic communication development and providing communication opportunities for the children with severe and profound disabilities in their care. In South Africa, these children are often the most neglected in terms of planning and providing appropriate interventions. For those with severe communication disabilities, an additional lack is in the area of the basic human right to meaningful interactions and communication. Sustainable strategies to provide opportunities for basic communication development of these children are urgently sought. Several effective international and local parent training programmes have been developed, but the urgent need remains to train centre-based carers who are taking care of groups of diversely disabled children in severely under-resourced settings. Non-profit organisations (NPOs have been exploring practical centre-based approaches to skills sharing in physical rehabilitation, activities for daily living, feeding and support for basic communication development. As a freelance speech therapist contracted by four NPOs to implement hands-on training in basic communication for centre-based carers of non-verbal children, the author describes a training approach that evolved over three years, in collaboration with the carers and centre managements. Implications for training (for speech therapists and for community-based rehabilitation workers and for further research are identified.

  1. A glass crown for the Malley shopping centre; Une couronne de verre pour Malley centre

    Energy Technology Data Exchange (ETDEWEB)

    Busson, F.

    2000-07-01

    The article describes the construction of the Malley shopping centre, Lausanne, Switzerland. The most interesting feature is the double-skin glass facade installed on the metallic structure of the main tower. The ventilation of the space between the two glass layers, typically a half-meter wide, allows a precise regulation of the building internal temperature. A compromise was found for the ventilation rate in order to simultaneously achieve an acceptable heat loss rate and a good acoustical protection by the facade. In addition to the common advantages of all types of metal and glass facades, this technique permits to lodge the venetian blinds as well as technical equipment on the internal skin, thus protecting them from climatic constraints and improving at the same time the architectural appearance of the building from outside.

  2. Women Labour in Call Centres: Understanding Characteristics of Work

    Directory of Open Access Journals (Sweden)

    Gulten Dursun

    2014-07-01

    Full Text Available This paper is concerned with the work experiences of women employees in info-service-based offices as telephone call centres. Call centres have grown rapidly in Tur-key in recent years, creating a large number of new jobs. In particular, it is concerned with the question of whether call centre jobs are offering women new opportunities for career progression, or whether a more common bias is taking place in which women are being drawn into highly routinized jobs. The collection of data was carried out so-urcing a heterogeneous plurality of instruments. Our research confirms that work pro-cesses in call centres are close association of surveillance technologies (technologic panoptican, exploitation and high levels of discipline, highly repetitive and heavily mo-nitored, and that the association with the assembly line and Taylorism have dominated much of the rhetoric on call centres. In addition, we have observed that, the structure of women’s employment in the call centre industry tends to polarise.

  3. A relational conceptual framework for multidisciplinary health research centre infrastructure

    Directory of Open Access Journals (Sweden)

    Johnson Joy L

    2010-10-01

    Full Text Available Abstract Although multidisciplinary and team-based approaches are increasingly acknowledged as necessary to address some of the most pressing contemporary health challenges, many researchers struggle with a lack of infrastructure to facilitate and formalise the requisite collaborations. Specialised research centres have emerged as an important organisational solution, yet centre productivity and sustainability are frequently dictated by the availability and security of infrastructure funds. Despite being widely cited as a core component of research capacity building, infrastructure as a discrete concept has been rather analytically neglected, often treated as an implicit feature of research environments with little specification or relegated to a narrow category of physical or administrative inputs. The terms research infrastructure, capacity, and culture, among others, are deployed in overlapping and inconsistent ways, further obfuscating the crucial functions of infrastructure specifically and its relationships with associated concepts. The case is made for an expanded conceptualisation of research infrastructure, one that moves beyond conventional 'hardware' notions. Drawing on a case analysis of NEXUS, a multidisciplinary health research centre based at the University of British Columbia, Canada, a conceptual framework is proposed that integrates the tangible and intangible structures that interactively underlie research centre functioning. A relational approach holds potential to allow for more comprehensive accounting of the returns on infrastructure investment. For those developing new research centres or seeking to reinvigorate existing ones, this framework may be a useful guide for both centre design and evaluation.

  4. Low-temperature pair associates of H centres in KBr

    Energy Technology Data Exchange (ETDEWEB)

    Akilbekov, A.; Elango, A.

    1984-04-01

    In the course of investigating the annealing of KBr crystals X-rayed at 4.2 K the creation of new pair associates of interstitial halogen atoms (di-H centres) with an absorption band at 3.85 eV is detected. The 3.85 centres arise only as a result of thermodestruction of the well-known di-H centres with an absorption band at 4.4 eV. The properties of these new centres are studied and the possible ways of halogen association in KBr are discussed. As a model for the 3.85 centres a model of (Br/sub 2//sup -/)/sub 2/ dimers is proposed, in which the optical transition differs from that in Br/sub 2//sup -/ ions both by size and direction. The range of KBr absorption spectra between Br/sub 2//sup -/ and Br/sub 3//sup -/ absorptions (3.6 to 4.4 eV) is attributed to the absorption of (Br/sub 2//sup -/)/sub 2/ dimers. The V/sub 4A/ centres in KBr with Li or Na impurities have obviously also a (Br/sub 2//sup -/)/sub 2/ structure.

  5. Development and piloting the Woman Centred Care Scale (WCCS).

    Science.gov (United States)

    Brady, Susannah; Bogossian, Fiona; Gibbons, Kristen

    2017-06-01

    In midwifery we espouse a woman centred care approach to practice, yet in midwifery education no valid instrument exists with which to measure the performance of these behaviours in midwifery students. To develop and validate an instrument to measure woman centred care behaviours in midwifery students. We identified four core concepts; woman's sphere, holism, self-determination and the shared power relationship. We mapped 18 individual descriptive care behaviours (from the Australian National Competency Standards for the Midwife) to these concepts to create an instrument to articulate and measure care behaviours that are specifically woman centred. Review by expert midwifery clinicians ensured face, content and construct validity of the scale and predictive validity and reliability were tested in a simulated learning environment. Midwifery students were video recorded performing a clinical skill and the videos were reviewed and rated by two expert clinicians who assessed the woman centred care behaviours demonstrated by the students (n=69). Test and re-test reliability of the instrument was high for each of the individual raters (Kappa 0.946 and 0.849 respectively pcentred care behaviours (Kappa 0.470, pstudents who had repeated exposures to higher levels of simulation fidelity demonstrated higher levels of woman centred care behaviours. The WCCS has implications for education and the wider midwifery profession in recognising and maintaining practice consistent with the underlying philosophy of woman centred care. Copyright © 2016 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  6. Transportation Development Centre annual review, 1997-1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    Report describing the activities and accomplishments of the Transportation Development Centre (TDC) for the fiscal year ending March 31, 1998 is presented. The role of the TDC is to improve the safety, security, energy efficiency and accessibility of the Canadian transportation system while protecting the environment. From a management perspective, one of the important developments during the reporting year was a new framework for research and development in Transport Canada, which defines a process for identifying and setting departmental research and development priorities. The year also marked the finalization of a five-year science and technology plan for increased cooperation in the field of North American transportation technologies. Among research and development highlights in air, marine, road and rail transportation work done on aircraft takeoff behaviour of failed de-icing fluids; the winter runway friction measurement program; revision of flight recorder configuration standards; development of a new child safety system; a ship-based search and rescue radar detection system; research on flooding protection of ro-ro ferries; completion of a study on leak-before-burst performance of various designs of natural gas vehicle cylinders; work on school bus safety and a thermal management system for road vehicles; plastic- lined traction motor bearings for locomotives, and work on a guided radar system designed to detect rock falls and washouts, were singled out. Progress related to issues regarding the transportation of dangerous goods, transportation accessibility, human factors and security are also reported. A financial overview which provides a detailed breakdown of TDC`s funding and funding sources for 1997-98 is also included. tabs., figs.

  7. Comparison of planned menus and centre characteristics with foods and beverages served in New York City child-care centres

    Science.gov (United States)

    Breck, Andrew; Dixon, L Beth; Khan, Laura Kettel

    2016-01-01

    Objective The present study evaluated the extent to which child-care centre menus prepared in advance correspond with food and beverage items served to children. The authors identified centre and staff characteristics that were associated with matches between menus and what was served. Design Menus were collected from ninety-five centres in New York City (NYC). Direct observation of foods and beverages served to children were conducted during 524 meal and snack times at these centres between April and June 2010, as part of a larger study designed to determine compliance of child-care centres with city health department regulations for nutrition. Setting Child-care centres were located in low-income neighbourhoods in NYC. Results Overall, 87% of the foods and beverages listed on the menus or allowed as substitutions were served. Menu items matched with foods and beverages served for all major food groups by > 60%. Sweets and water had lower match percentages (40 and 32%, respectively), but water was served 68% of the time when it was not listed on the menu. The staff person making the food and purchasing decisions predicted the match between the planned or substituted items on the menus and the foods and beverages served. Conclusions In the present study, child-care centre menus included most foods and beverages served to children. Menus planned in advance have potential to be used to inform parents about which child-care centre to send their child or what foods and beverages their enrolled children will be offered throughout the day. PMID:27280341

  8. 利用功能磁共振成像定位人双眼垂直协同运动皮质中枢%Study on the location of cortical centre of binocular vertical movement in human by fMRI

    Institute of Scientific and Technical Information of China (English)

    钟士江; 李平; 包春雨

    2012-01-01

    [目的]确定人调控双眼垂直协同运动皮质中枢的位置.[方法]选择健康人12名作为受试者,功能磁共振成像(fMRI)使用GE Signa Highspeed MR/i 1.5T超导MRI仪及血氧水平依赖法(BOLD)fMRI技术对功能区进行成像.[结果]被激活脑区位于双侧额叶,集中于Brodmann 8区和6区的位置;功能信号强度及范围:右侧为主4例,左侧为主3例,单侧3例,双侧对称2例.[结论]人调控双眼垂直协同运动的皮质中枢位于Brodmann 8区和6区的位置;功能活动有偏侧、单侧及对称特点.fMRI是定位脑功能的有效工具.%[Objective] To locate the cortical centre of binocular vertical movement in humaan. [Methods] A total of 12 healthy subjects were selected in this experiment and scanned by GE Signa Highspeed MR/i 1.5 Tesla superconductive MRI system. Blood oxygenation level dependent(BOLD) method was used. [Results] Activation areas were found in the Brodmann area 8 and 6. The range and intensity of f unctional signals were: 4 cases mainly on the right side, 3 cases mainly on the left side and 3 cases only on one side, 2 cases symmetrically on both hemisphere. [Conclusions] The cortical centre of binocular vertical movement lies on the Brodmann area 8 and 6. Functional signals possess the asymmetric, symmetric and unilateral features.fMRI is an effective tool to locate the cortical centres.

  9. Assessing health centre systems for guiding improvement in diabetes care

    Directory of Open Access Journals (Sweden)

    Robinson Gary

    2005-08-01

    Full Text Available Abstract Background Aboriginal people in Australia experience the highest prevalence of diabetes in the country, an excess of preventable complications and early death. There is increasing evidence demonstrating the importance of healthcare systems for improvement of chronic illness care. The aims of this study were to assess the status of systems for chronic illness care in Aboriginal community health centres, and to explore whether more developed systems were associated with better quality of diabetes care. Methods This cross-sectional study was conducted in 12 Aboriginal community health centres in the Northern Territory of Australia. Assessment of Chronic Illness Care scale was adapted to measure system development in health centres, and administered by interview with health centre staff and managers. Based on a random sample of 295 clinical records from attending clients with diagnosed type 2 diabetes, processes of diabetes care were measured by rating of health service delivery against best-practice guidelines. Intermediate outcomes included the control of HbA1c, blood pressure, and total cholesterol. Results Health centre systems were in the low to mid-range of development and had distinct areas of strength and weakness. Four of the six system components were independently associated with quality of diabetes care: an increase of 1 unit of score for organisational influence, community linkages, and clinical information systems, respectively, was associated with 4.3%, 3.8%, and 4.5% improvement in adherence to process standards; likewise, organisational influence, delivery system design and clinical information systems were related to control of HbA1c, blood pressure, and total cholesterol. Conclusion The state of development of health centre systems is reflected in quality of care outcome measures for patients. The health centre systems assessment tool should be useful in assessing and guiding development of systems for improvement of

  10. The oral food desensitization in the Italian allergy centres.

    Science.gov (United States)

    Meglio, P; Caminiti, L; Pajno, G B; Dello Iacono, I; Tripodi, S; Verga, M C; Martelli, A

    2015-05-01

    Attempts aimed at inducing food tolerance through oral food desensitization (OFD) for the treatment of IgE-mediated food allergies are increasing. In Italy, a number of allergy centres offer this procedure. To collect information on how these centres are organized, how patients are selected, the methods used to administer OFD and how adverse reactions are managed. A questionnaire was e-mailed to all the Italian allergy centres offering OFD. The survey shows a high degree of variability between centres. A correct diagnosis of food allergy is crucial for selecting patients for OFD. In the Italian allergy centres, oral food challenges are mostly open label (84%), but in 16% of cases they are single-blind (8%) or double-blind (8%). A high proportion of allergy centres (83%) offer OFD to children presenting forms of anaphylaxis triggered by traces--or very low doses--of food allergen. The majority of allergy centres (76%) enroll patients over 3 years of age, with 44% enrolling patients above the age of 5. Not-controlled asthma, unreliability of parents in the management of OFD and/or risk of adverse events, are the main reasons for exclusion from the procedure. Although OFD may sometimes be successful and may be considered a valid alternative to an elimination diet, further randomized controlled trials are needed, in order to clarify some controversial points, such as the characteristics of the child undergoing OFD, and the methods of food preparation and administration. Moreover, further studies should further investigate OFD safety, efficacy and costs.

  11. Norway's centres for environment-friendly energy research (CEERs)

    Energy Technology Data Exchange (ETDEWEB)

    2009-07-01

    In February 2009 Norway's Minister of Petroleum and Energy announced the establishment of eight new Centres for Environment-friendly Energy Research (CEERs). The centres form national teams within the areas of offshore wind energy, solar energy, energy efficiency, bio energy, energy planning and design, and carbon capture and storage. These centres are: BIGCCS Centre - International CCS Research Centre; Centre for Environmental Design of Renewable Energy (CEDREN); Bioenergy Innovation Centre (CenBio); Norwegian Centre for Offshore Wind Energy (NORCOW E); Norwegian Research Centre for Offshore Wind Technology (NOWITECH); The Norwegian Research Centre for Solar Cell Technology; SUbsurface CO{sub 2} storage - Critical Elements and Superior Strategy (SUCCESS) The Research Centre on Zero Emission Buildings - ZEB (AG)

  12. The Yale Cost Model and cost centres: servant or master?

    Science.gov (United States)

    Rigby, E

    1993-01-01

    Cost accounting describes that aspect of accounting which collects, allocates and controls the cost of producing a service. Costing information is primarily reported to management to enable control of costs and to ensure the financial viability of units, departments and divisions. As costing studies continue to produce estimates of Diagnosis Related Group (DRG) costs in New South Wales hospitals, as well as in other states, costs for different hospitals are being externally compared, using a tool which is usually related to internal management and reporting. Comparability of costs is assumed even though accounting systems differ. This paper examines the cost centre structures at five major teaching hospitals in Sydney. It describes the similarities and differences in how the cost centres were constituted, and then details the line items of expenditure that are charged to each cost centre. The results of a comparative study of a medical specialty are included as evidence of different costing methodologies in the hospitals. The picture that emerged from the study is that the hospitals are constituting their cost centres to meet their internal management needs, that is, to know the cost of running a ward or nursing unit, a medical specialty, department and so on. The rationale for the particular cost centre construction was that cost centre managers could manage and control costs and assign responsibility. There are variations in procedures for assigning costs to cost centres, and the question is asked 'Do these variations in procedures make a material difference to our ability to compare costs per Diagnosis Related Group at the various hospitals?' It is contended that the accounting information, which is produced as a result of different practices, is primarily for internal management, not external comparison. It would be better for hospitals to compare their estimated costs per Diagnosis Related Group to an internal standard cost rather than the costs from other

  13. Do flow principles of operations management apply to computing centres?

    CERN Document Server

    Abaunza, Felipe; Hameri, Ari-Pekka; Niemi, Tapio

    2014-01-01

    By analysing large data-sets on jobs processed in major computing centres, we study how operations management principles apply to these modern day processing plants. We show that Little’s Law on long-term performance averages holds to computing centres, i.e. work-in-progress equals throughput rate multiplied by process lead time. Contrary to traditional manufacturing principles, the law of variation does not hold to computing centres, as the more variation in job lead times the better the throughput and utilisation of the system. We also show that as the utilisation of the system increases lead times and work-in-progress increase, which complies with traditional manufacturing. In comparison with current computing centre operations these results imply that better allocation of jobs could increase throughput and utilisation, while less computing resources are needed, thus increasing the overall efficiency of the centre. From a theoretical point of view, in a system with close to zero set-up times, as in the c...

  14. Client-centred occupational therapy: the importance of critical perspectives.

    Science.gov (United States)

    Whalley Hammell, Karen R

    2015-07-01

    The occupational therapy profession has proclaimed itself to be client-centred for over 30 years, but until recently this assertion remained largely unchallenged. Critical thinkers, who have begun to explore client-centred practice in occupational therapy, highlight the necessity for further critical reflection. This paper aims to define what constitutes "critical" thinking; and to persuade occupational therapists of the importance of employing critical perspectives towards the profession's assumptions and assertions regarding occupational therapy's "client-centred" practices. Critical thinking is not solely a process of carefully and thoughtfully weighing various arguments or evidence, but of additionally appraising the ideological and structural contexts in which these positions or evidence have arisen. Critical perspectives towards occupational therapy's client-centred practices identify the ways in which power is exercised by the profession, and culturally specific and disabling ideologies are perpetuated. Critical thinking enables occupational therapists to reflect on their own inequitable access to privilege and power, and reduces the potential for the profession to re-inscribe dominant ideologies that devalue disabled people and justify their inequitable opportunities. Because critical thinking demands a readiness to restructure one's thinking, and decreases the risk of acting on faulty assumptions, it is an essential component of client-centred practice.

  15. Experience Building and Operating the CMS Tier-1 Computing Centres

    CERN Document Server

    Albert, M; Bonacorsi, D; Brew, C; Charlot, C; Huang, Chih-Hao; Colling, D; Dumitrescu, C; Fagan, D; Fassi, F; Fisk, I; Flix, J; Giacchetti, L; Gomez-Ceballos, G; Gowdy, S; Grandi, C; Gutsche, O; Hahn, K; Holzman, B; Jackson, J; Kreuzer, P; Kuo, C M; Mason, D; Pukhaeva, N; Qin, G; Quast, G; Rossman, P; Sartirana, A; Scheurer, A; Schott, G; Shih, J; Tader, P; Thompson, R; Tiradani, A; Trunov, A

    2010-01-01

    The CMS Collaboration relies on 7 globally distributed Tier-1 computing centres located at large universities and national laboratories for a second custodial copy of the CMS RAW data and primary copy of the simulated data, data serving capacity to Tier-2 centres for analysis, and the bulk of the reprocessing and event selection capacity in the experiment. The Tier-1 sites have a challenging role in CMS because they are expected to ingest and archive data from both CERN and regional Tier-2 centres, while they export data to a global mesh of Tier-2s at rates comparable to the raw export data rate from CERN. The combined capacity of the Tier-1 centres is more than twice the resources located at CERN and efficiently utilizing this large distributed resources represents a challenge. In this article we will discuss the experience building, operating, and utilizing the CMS Tier-1 computing centres. We will summarize the facility challenges at the Tier-1s including the stable operations of CMS services, the ability ...

  16. The CERN Control Centre is up and running!

    CERN Multimedia

    2006-01-01

    The CERN Control Centre (CCC) that combines all the control rooms for the accelerators, the cryogenic system and the technical infrastructure came into operation on 1st February. This is not a mock-up but the real thing! The CERN Control Centre has been built and put into operation in only 15 months.On 1st February, at 2.00 p.m., Patrick Villeton Pachot started the first Technical Infrastructure shift at the brand new CERN Control Centre. From now on, when you dial 72201 to report a leak or an electrical fault, your call will ring out in the brand new CERN Control Centre. The much anticipated CCC came on line on 1st February, exactly as planned. The 2.00 p.m. shift by the operators of the former Technical Control Room (TCR), now renamed TI for Technical Infrastructure, marked the start of operations at the Centre. The PCR, MCR, TCR and QCR are no more, and all the individual control rooms have been merged into one. And what a control room it is! True to the streamlined image announced when the project was f...

  17. Unified storage systems for distributed Tier-2 centres

    CERN Document Server

    Cowan, Greig A; Elwell, Andrew

    2008-01-01

    The start of data taking at the Large Hadron Collider will herald a new era in data volumes and distributed processing in particle physics. Data volumes of hundreds of Terabytes will be shipped to Tier-2 centres for analysis by the LHC experiments using the Worldwide LHC Computing Grid (WLCG). In many countries Tier-2 centres are distributed between a number of institutes, e.g., the geographically spread Tier-2s of GridPP in the UK. This presents a number of challenges for experiments to utilise these centres efficaciously, as CPU and storage resources may be sub-divided and exposed in smaller units than the experiment would ideally want to work with. In addition, unhelpful mismatches between storage and CPU at the individual centres may be seen, which make efficient exploitation of a Tier-2's resources difficult. One method of addressing this is to unify the storage across a distributed Tier-2, presenting the centres' aggregated storage as a single system. This greatly simplifies data management for the VO, ...

  18. Higgs Reconstructed at CERN’s Computer Centre

    CERN Multimedia

    2012-01-01

    Thanks to the enormous computing capacity of the CERN Computer Centre, which hosts about 12,000 servers with 16,000 CPUs (i.e. 64,000 computing cores) and 64,000 hard-disks distributed over 1,100 racks and storing another 22 PB (PetaByte, i.e. 22 million billion bytes) of LHC data during 2011, CERN computing specialists have managed for the first time to reconstruct the “Higgs” (see photo below in which the newly installed racks are highlighted).   In fact, as clear physics evidence of the Higgs is still pending and expected to be established in 2012, the CERN Computer Centre operators have instead rearranged their computer racks in the Computer Centre (Building 513) to spell the word “Higgs”. Bruce Peppa, group leader of the IT/CC group who manages the Computer Centre, said “As many people have noticed, for a few months serious construction work has been going on in the annex to the CERN Computer Centre. With the installation of more servers ...

  19. Antimycobacterial activity evaluation and MIC determination of liophilizated hydroalcoholic extracts of Bixa orellana L., Bixaceae Avaliação da atividade antimicobacteriana e a determinação da CIM de extratos hidroalcoólicos liofilizados de Bixa orellana L., Bixaceae

    Directory of Open Access Journals (Sweden)

    Renata B. Silva

    2010-05-01

    Full Text Available Bixa orellana is used in popular medicine against several diseases. Extracts of its fruit, root and leaf presented antimicrobial activity, while seed extract showed negative results. This study aimed at verifying the antimycobacterial activity of B. orellanalyophilized hydroalcoholic extracts over Mycobacterium tuberculosis, and determine the Minimum Inhibitory Concentration against five bacteria. Antimycobacterial activity was determined by diffusion technique, while MIC was assessed by diffusion and colorimetric analysis. MICs were 0.3, 0.5 and 0.2 mg/mL respectively, for leaf, root and stem extracts, against M. tuberculosis. Stem's extract showed 1.2 mg/mL for B. cereus, 1.53 mg/mL for S. aureusand S. typhimurium, 4.50 mg/mL for P. aeruginosaand 8.01 mg/mL for P. mirabillis.Leaf extracts showed 0.66 mg/mL for P. aeruginosa, 0.94 mg/mL for P. mirabillis, 1.88 mg/mL for S. aureus, 3.95 mg/mL for B. cereusand 8.37 mg/mL for S. typhimurium. Root's extracts showed 0.25 mg/mL for P. aeruginosa,0.31 mg/mL for S. aureus, 0.62 mg/mL for S. typhimuriumand 3.00 mg/mL for B. cereusand P. mirabillis. Leaf and stem extracts showed antimycobacterial activity. MICs were lower in colorimetric analysis than in agar diffusion. Extracts revealed bacteriostatic activity against the five bacterial.Bixa orellana é usada na medicina popular em várias doenças. Extratos do fruto, raiz e folhas apresentaram atividade antimicrobiana, enquanto extratos do caule mostraram resultados negativos. Este estudo teve por objetivo verificar a atividade antimicobacteriana de extratos hidroalcoólicos liofilizados de B. orellanafrente Mycobacterium tuberculosis e determinar a Concentração Inibitória Mínima para cinco bactérias. A atividade antimicobacteriana foi determinada por difusão e a CIM por difusão e análise colorimétrica. As CIM foram 0,3, 0,5 e 0,2 mg/mL para os extratos de folhas, raiz e caule frente M. tuberculosis. Os extratos de caule demonstraram CIM de 1

  20. From "Animal Machines" to "Happy Meat"? Foucault's Ideas of Disciplinary and Pastoral Power Applied to 'Animal-Centred' Welfare Discourse.

    Science.gov (United States)

    Cole, Matthew

    2011-01-11

    Michel Foucault's work traces shifting techniques in the governance of humans, from the production of 'docile bodies' subjected to the knowledge formations of the human sciences (disciplinary power), to the facilitation of self-governing agents directed towards specified forms of self-knowledge by quasi-therapeutic authorities (pastoral power). While mindful of the important differences between the governance of human subjects and the oppression of nonhuman animals, exemplified in nonhuman animals' legal status as property, this paper explores parallel shifts from disciplinary to pastoral regimes of human-'farmed' animal relations. Recent innovations in 'animal-centred' welfare science represent a trend away from the 'disciplinary' techniques of confinement and torture associated with 'factory farms' and towards quasi-therapeutic ways of claiming to know 'farmed' animals, in which the animals themselves are co-opted into the processes by which knowledge about them is generated. The new pastoral turn in 'animal-centred' welfare finds popular expression in 'happy meat' discourses that invite 'consumers' to adopt a position of vicarious carer for the 'farmed' animals who they eat. The paper concludes that while 'animal-centred' welfare reform and 'happy meat' discourses promise a possibility of a somewhat less degraded life for some 'farmed' animals, they do so by perpetuating exploitation and oppression and entrenching speciesist privilege by making it less vulnerable to critical scrutiny.