WorldWideScience

Sample records for human balance system

  1. Impact of electromagnetic fields on human vestibular system and standing balance: pilot results and future developments

    Science.gov (United States)

    Allen, A.; Villard, S.; Corbacio, M.; Goulet, D.; Plante, M.; Souques, M.; Deschamps, F.; Ostiguy, G.; Lambrozo, J.; Thomas, A. W.; Legros, A.

    2016-03-01

    Although studies have found that extremely low-frequency (ELF, fields (MF) can modulate human standing balance, the acute effects of electromagnetic fields on standing balance have not been systematically investigated. This work aims to establish the threshold for acute standing balance modulation during ELFMF exposure. One hundred volunteers will be exposed to transcranial electric stimulations (Direct Current - DC and Alternating Current - AC, 1 mA) and ELFMF (0 to 160 Hz, 0 to 100 mT). The displacement of their center of pressure will be collected and analyzed as an indicator of vestibular performance. During pilot testing (n=6), we found increased lateral sway with DC, and to a lesser extent, AC exposure. The ELFMF exposure system still needs to be adapted to allow meaningful results. Future protocol design will test for possible effects due to exposures in the radiofrequency range (i.e. above 3 kHz). These results will contribute to the literature documenting exposure guidelines aiming to protect workers and the general public.

  2. ADJUSTING THE HUMAN RESOURCES INFORMATION SYSTEM TO THE REQUIREMENTS OF USING THE BALANCED SCORECARD

    OpenAIRE

    Dan Constantin Varzaru; Anca Antoaneta Varzaru

    2015-01-01

    Engaging the human resources structure in the strategic design and implementation stages is closely connected to the enhancement of its capabilities towards undertaking and handling transformational activities, which have a direct contribution in increasing the added value of an organization. This way, transformational activities enhance the strategic importance and the prominence of the human resources function within organizations. The employment of the Balanced Scorecard stands out as a po...

  3. A dynamic human water and electrolyte balance model for verification and optimization of life support systems in space flight applications

    Science.gov (United States)

    Hager, P.; Czupalla, M.; Walter, U.

    2010-11-01

    In this paper we report on the development of a dynamic MATLAB SIMULINK® model for the water and electrolyte balance inside the human body. This model is part of an environmentally sensitive dynamic human model for the optimization and verification of environmental control and life support systems (ECLSS) in space flight applications. An ECLSS provides all vital supplies for supporting human life on board a spacecraft. As human space flight today focuses on medium- to long-term missions, the strategy in ECLSS is shifting to closed loop systems. For these systems the dynamic stability and function over long duration are essential. However, the only evaluation and rating methods for ECLSS up to now are either expensive trial and error breadboarding strategies or static and semi-dynamic simulations. In order to overcome this mismatch the Exploration Group at Technische Universität München (TUM) is developing a dynamic environmental simulation, the "Virtual Habitat" (V-HAB). The central element of this simulation is the dynamic and environmentally sensitive human model. The water subsystem simulation of the human model discussed in this paper is of vital importance for the efficiency of possible ECLSS optimizations, as an over- or under-scaled water subsystem would have an adverse effect on the overall mass budget. On the other hand water has a pivotal role in the human organism. Water accounts for about 60% of the total body mass and is educt and product of numerous metabolic reactions. It is a transport medium for solutes and, due to its high evaporation enthalpy, provides the most potent medium for heat load dissipation. In a system engineering approach the human water balance was worked out by simulating the human body's subsystems and their interactions. The body fluids were assumed to reside in three compartments: blood plasma, interstitial fluid and intracellular fluid. In addition, the active and passive transport of water and solutes between those

  4. Balancing for unstable nonlinear systems

    NARCIS (Netherlands)

    Scherpen, J.M.A.

    1993-01-01

    A previously obtained method of balancing for stable nonlinear systems is extended to unstable nonlinear systems. The similarity invariants obtained by the concept of LQG balancing for an unstable linear system can also be obtained by considering a past and future energy function of the system. By c

  5. Rotor balancing apparatus and system

    Science.gov (United States)

    Lyman, Frank (Inventor); Lyman, Joseph (Inventor)

    1976-01-01

    Rotor balancing apparatus and a system comprising balance probes for measuring unbalance at the ends of a magnetically suspended rotor are disclosed. Each balance probe comprises a photocell which is located in relationship to the magnetically suspended rotor such that unbalance of the rotor changes the amount of light recorded by each photocell. The signal from each photocell is electrically amplified and displayed by a suitable device, such as an oscilloscope.

  6. Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells.

    Science.gov (United States)

    Linher-Melville, Katja; Haftchenary, Sina; Gunning, Patrick; Singh, Gurmit

    2015-07-01

    System Xc- is a cystine/glutamate antiporter that contributes to the maintenance of cellular redox balance. The human xCT (SLC7A11) gene encodes the functional subunit of system Xc-. Transcription factors regulating antioxidant defense mechanisms including system Xc- are of therapeutic interest, especially given that aggressive breast cancer cells exhibit increased system Xc- function. This investigation provides evidence that xCT expression is regulated by STAT3 and/or STAT5A, functionally affecting the antiporter in human breast cancer cells. Computationally analyzing two kilobase pairs of the xCT promoter/5' flanking region identified a distal gamma-activated site (GAS) motif, with truncations significantly increasing luciferase reporter activity. Similar transcriptional increases were obtained after treating cells transiently transfected with the full-length xCT promoter construct with STAT3/5 pharmacological inhibitors. Knock-down of STAT3 or STAT5A with siRNAs produced similar results. However, GAS site mutation significantly reduced xCT transcriptional activity, suggesting that STATs may interact with other transcription factors at more proximal promoter sites. STAT3 and STAT5A were bound to the xCT promoter in MDA-MB-231 cells, and binding was disrupted by pre-treatment with STAT inhibitors. Pharmacologically suppressing STAT3/5 activation significantly increased xCT mRNA and protein levels, as well as cystine uptake, glutamate release, and total levels of intracellular glutathione. Our data suggest that STAT proteins negatively regulate basal xCT expression. Blocking STAT3/5-mediated signaling induces an adaptive, compensatory mechanism to protect breast cancer cells from stress, including reactive oxygen species, by up-regulating xCT expression and the function of system Xc-. We propose that targeting system Xc- together with STAT3/5 inhibitors may heighten therapeutic anti-cancer effects.

  7. Identifying Balance in a Balanced Scorecard System

    Science.gov (United States)

    Aravamudhan, Suhanya; Kamalanabhan, T. J.

    2007-01-01

    In recent years, strategic management concepts seem to be gaining greater attention from the academicians and the practitioner's alike. Balanced Scorecard (BSC) concept is one such management concepts that has spread in worldwide business and consulting communities. The BSC translates mission and vision statements into a comprehensive set of…

  8. Quantification of sensory information in human balance control

    NARCIS (Netherlands)

    Kooij, van der Herman; Koopman, Bart; Jacobs, Ron; Mergner, Thomas; Grootenboer, Henk

    1998-01-01

    A human balance control model is developed, which includes the different sensory systems as well as neural time delays. The model is based on optimal control theory. Platform perturbation experiments were done to quantify the precision of the different sensory systems by matching model predictions w

  9. The Dynamic Balancer electrical safety systems

    Energy Technology Data Exchange (ETDEWEB)

    Konkel, H.

    1997-12-01

    The Pantex Plant Dynamic Balancer is used to identify physical imbalance in some weapon systems. This study was conducted at the request of the US Department of Energy/Albuquerque Operations Office (USDOE/AL) Dynamic Balancer Project Team to identify the electrical conditions required for motor over-speed to occur and to discuss the functions of the various electrical protective features associated with the Dynamic Balancer (DB). As is shown through the development of a fault tree, numerous electrical and human failures are required for over-speed conditions to occur. As directed by the Project Team, no effort was made to develop detailed fault trees for all electrical systems, to quantify basic events in the fault tree, or to develop accident scenarios leading to or resulting from over-speed. The Pantex Building 12-60, Bay 2, facility electrical circuits and grounding are described, and potential hazards are discussed. DB motor over-speed is a safety concern, and therefore, the controls that limit this condition are described and discussed in detail. Other safety-significant electrical circuits are discussed as well. These safety systems also are described in the facility Basis for Interim Operation. A potential for a motor over-speed that is not sensed by the standard safety protective systems does exist. This fault pathway is discussed, and recommendations to mitigate its effect are made.

  10. Balancing of Lossless and Passive Systems

    NARCIS (Netherlands)

    Schaft, Arjan van der

    2008-01-01

    Different balancing techniques are applied to lossless nonlinear systems, with open-loop balancing applied to their scattering representation. It is shown that they all lead to the same result: the pair of to-be-balanced functions is given by two copies of the physical energy function, yielding thus

  11. Balancing of Lossless and Passive Systems

    NARCIS (Netherlands)

    Schaft, Arjan van der

    2008-01-01

    Different balancing techniques are applied to lossless nonlinear systems, with open-loop balancing applied to their scattering representation. It is shown that they all lead to the same result: the pair of to-be-balanced functions is given by two copies of the physical energy function, yielding thus

  12. Single Switched Capacitor Battery Balancing System Enhancements

    Directory of Open Access Journals (Sweden)

    Joeri van Mierlo

    2013-04-01

    Full Text Available Battery management systems (BMS are a key element in electric vehicle energy storage systems. The BMS performs several functions concerning to the battery system, its key task being balancing the battery cells. Battery cell unbalancing hampers electric vehicles’ performance, with differing individual cell voltages decreasing the battery pack capacity and cell lifetime, leading to the eventual failure of the total battery system. Quite a lot of cell balancing topologies have been proposed, such as shunt resistor, shuttling capacitor, inductor/transformer based and DC energy converters. The shuttling capacitor balancing systems in particular have not been subject to much research efforts however, due to their perceived low balancing speed and high cost. This paper tries to fill this gap by briefly discussing the shuttling capacitor cell balancing topologies, focusing on the single switched capacitor (SSC cell balancing and proposing a novel procedure to improve the SSC balancing system performance. This leads to a new control strategy for the SSC system that can decrease the balancing system size, cost, balancing time and that can improve the SSC balancing system efficiency.

  13. Microprocessor-Controlled Laser Balancing System

    Science.gov (United States)

    Demuth, R. S.

    1985-01-01

    Material removed by laser action as part tested for balance. Directed by microprocessor, laser fires appropriate amount of pulses in correct locations to remove necessary amount of material. Operator and microprocessor software interact through video screen and keypad; no programing skills or unprompted system-control decisions required. System provides complete and accurate balancing in single load-and-spinup cycle.

  14. Control of thermal balance by a liquid circulating garment based on a mathematical representation of the human thermoregulatory system. Ph.D. Thesis - California Univ., Berkeley

    Science.gov (United States)

    Kuznetz, L. H.

    1976-01-01

    Test data and a mathematical model of the human thermoregulatory system were used to investigate control of thermal balance by means of a liquid circulating garment (LCG). The test data were derived from five series of experiments in which environmental and metabolic conditions were varied parametrically as a function of several independent variables, including LCG flowrate, LCG inlet temperature, net environmental heat exchange, surrounding gas ventilation rate, ambient pressure, metabolic rate, and subjective/obligatory cooling control. The resultant data were used to relate skin temperature to LCG water temperature and flowrate, to assess a thermal comfort band, to demonstrate the relationship between metabolic rate and LCG heat dissipation, and so forth. The usefulness of the mathematical model as a tool for data interpretation and for generation of trends and relationships among the various physiological parameters was also investigated and verified.

  15. On balanced truncation for symmetric nonlinear systems

    NARCIS (Netherlands)

    Fujimoto, K.; Scherpen, Jacqueline M.A.

    2014-01-01

    This paper is concerned with model order reduction based on balanced realization for symmetric nonlinear systems. A new notion of symmetry for nonlinear systems was characterized recently. It plays an important role in linear systems theory and is expected to provide new insights to nonlinear system

  16. Efficacy of virtual reality-based balance training versus the Biodex balance system training on the body balance of adults

    OpenAIRE

    Ibrahim, Manal S.; Mattar, Ayman G.; Elhafez, Salam M.

    2016-01-01

    [Purpose] This study investigated efficacy of virtual reality (VR)-based balance training on enhancing balance and postural reactions of adults as a low-cost new modality compared to the established Biodex Balance System (BBS). [Subjects] Thirty normal adults of both genders were divided randomly into two equal-sized experimental groups of 15: BBS balance training and VR balance training. [Methods] The training programmes were conducted in 12 sessions, three 15-min sessions per week. The Nint...

  17. Balanced truncation for linear switched systems

    DEFF Research Database (Denmark)

    Petreczky, Mihaly; Wisniewski, Rafal; Leth, John-Josef

    2013-01-01

    in this paper, we provide a bound on the approximation error in the L2L2 norm for continuous-time and the l2l2 norm for discrete-time linear switched systems. We provide a system theoretic interpretation of grammians and their singular values. Furthermore, we show that the performance of balanced truncation...

  18. Balanced truncation for linear switched systems

    DEFF Research Database (Denmark)

    Petreczky, Mihaly; Wisniewski, Rafal; Leth, John-Josef

    2013-01-01

    in this paper, we provide a bound on the approximation error in the L2L2 norm for continuous-time and the l2l2 norm for discrete-time linear switched systems. We provide a system theoretic interpretation of grammians and their singular values. Furthermore, we show that the performance of balanced truncation...

  19. A public data set of human balance evaluations

    Directory of Open Access Journals (Sweden)

    Damiana A. Santos

    2016-11-01

    Full Text Available The goal of this study was to create a public data set with results of qualitative and quantitative evaluations related to human balance. Subject’s balance was evaluated by posturography using a force platform and by the Mini Balance Evaluation Systems Tests. In the posturography test, we evaluated subjects standing still for 60 s in four different conditions where vision and the standing surface were manipulated: on a rigid surface with eyes open; on a rigid surface with eyes closed; on an unstable surface with eyes open; on an unstable surface with eyes closed. Each condition was performed three times and the order of the conditions was randomized. In addition, the following tests were employed in order to better characterize each subject: Short Falls Efficacy Scale International; International Physical Activity Questionnaire Short Version; and Trail Making Test. The subjects were also interviewed to collect information about their socio-cultural, demographic, and health characteristics. The data set comprises signals from the force platform (raw data for the force, moments of forces, and centers of pressure of 163 subjects plus one file with information about the subjects and balance conditions and the results of the other evaluations. All the data is available at PhysioNet and at Figshare.

  20. Balanced bridge feedback control system

    Science.gov (United States)

    Lurie, Boris J. (Inventor)

    1990-01-01

    In a system having a driver, a motor, and a mechanical plant, a multiloop feedback control apparatus for controlling the movement and/or positioning of a mechanical plant, the control apparatus has a first local bridge feedback loop for feeding back a signal representative of a selected ratio of voltage and current at the output driver, and a second bridge feedback loop for feeding back a signal representative of a selected ratio of force and velocity at the output of the motor. The control apparatus may further include an outer loop for feeding back a signal representing the angular velocity and/or position of the mechanical plant.

  1. Human footprint affects US carbon balance more than climate change

    Science.gov (United States)

    Bachelet, Dominique; Ferschweiler, Ken; Sheehan, Tim; Baker, Barry; Sleeter, Benjamin M.; Zhu, Zhiliang

    2017-01-01

    The MC2 model projects an overall increase in carbon capture in conterminous United States during the 21st century while also simulating a rise in fire causing much carbon loss. Carbon sequestration in soils is critical to prevent carbon losses from future disturbances, and we show that natural ecosystems store more carbon belowground than managed systems do. Natural and human-caused disturbances affect soil processes that shape ecosystem recovery and competitive interactions between native, exotics, and climate refugees. Tomorrow's carbon budgets will depend on how land use, natural disturbances, and climate variability will interact and affect the balance between carbon capture and release.

  2. A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation.

    Science.gov (United States)

    Kumar, Deepesh; Das, Abhijit; Lahiri, Uttama; Dutta, Anirban

    2016-04-12

    A stroke is caused when an artery carrying blood from heart to an area in the brain bursts or a clot obstructs the blood flow to brain thereby preventing delivery of oxygen and nutrients. About half of the stroke survivors are left with some degree of disability. Innovative methodologies for restorative neurorehabilitation are urgently required to reduce long-term disability. The ability of the nervous system to reorganize its structure, function and connections as a response to intrinsic or extrinsic stimuli is called neuroplasticity. Neuroplasticity is involved in post-stroke functional disturbances, but also in rehabilitation. Beneficial neuroplastic changes may be facilitated with non-invasive electrotherapy, such as neuromuscular electrical stimulation (NMES) and sensory electrical stimulation (SES). NMES involves coordinated electrical stimulation of motor nerves and muscles to activate them with continuous short pulses of electrical current while SES involves stimulation of sensory nerves with electrical current resulting in sensations that vary from barely perceivable to highly unpleasant. Here, active cortical participation in rehabilitation procedures may be facilitated by driving the non-invasive electrotherapy with biosignals (electromyogram (EMG), electroencephalogram (EEG), electrooculogram (EOG)) that represent simultaneous active perception and volitional effort. To achieve this in a resource-poor setting, e.g., in low- and middle-income countries, we present a low-cost human-machine-interface (HMI) by leveraging recent advances in off-the-shelf video game sensor technology. In this paper, we discuss the open-source software interface that integrates low-cost off-the-shelf sensors for visual-auditory biofeedback with non-invasive electrotherapy to assist postural control during balance rehabilitation. We demonstrate the proof-of-concept on healthy volunteers.

  3. Phase balancing optimization for radial feeder systems

    Science.gov (United States)

    Zhu, Jinxiang

    In the power distribution systems, unbalanced feeder causes deteriorating power quality and increases investment and operating costs. There are two approaches to balance a feeder system. One approach is feeder reconfiguration, the other is phase swapping. Feeder reconfiguration is an on-line operation of sectionalizing switches. However, feeder reconfiguration is difficult to find the phase balancing solution for a unbalanced feeder system. On the other hand, phase swapping is a direct and effective approach for phase balancing. Phase swapping is an off-line operation of re-tapping loads/laterals to the phase lines during maintenance and restoration periods. Unfortunately, phase balancing problem has not received its deserved importance. Deregulation in power industry has arisen phase balancing issue because it can improve power quality, improve service reliability, and reduce total costs. Thus, phase balancing can enhance utility competitive capability. This research provides utilities the optimization tools to maximize the benefits of phase balancing and minimize the costs. This dissertation proposed several mathematical formulations, including Mixed-integer programming (MIP), Dynamic programming (DP), Simulated annealing (SA), and Fuzzy logic (FL), to perform phase swapping to balance phase in a radial feeder. Due to the discrete nature of phase swapping, a MIP model is proposed to find the optimal phase swapping scheme for small-sized feeder. Candidate sets and monitored branches are then introduced to solve the large-scale feeder systems. Possibilistic integer programming (PIP) is proposed to incorporate load uncertainties in phase swapping problems. The tests show that the load uncertainties may change the optimal phase swapping. DP computation is significant reduced by introducing the tighter upper/lower bounds. The upper bound can be quickly obtained by assignment algorithm. Even though SA is a time-consuming heuristic method, it can provide better solution

  4. Research of Human Postural Balance Parameters

    Directory of Open Access Journals (Sweden)

    Julius Griškevičius

    2011-02-01

    Full Text Available In present article postural balance between subjects with stroke and healthy subjects, is being investigated with eyes opened and eyes closed. In the research participated 30 healthy subjects and 15 subjects with stroke. At the same time two experimental measurements were performed – postural balance was measured using balance platform and oscillations of the centre of mass were observed using two-axial accelerometer. It was noted, that amplitudes of subjects with stroke were larger almost two times than control group’s of healthy subjects. It was find out, that ratios of pressure distribution on both left and right legs are in range from 1 to 0.9 for healthy subjects, and ratios below 0.9 are common for subjects with stroke. When subjects were standing with eyes closed, sway amplitudes were higher and the ratios of load distribution on left and right legs were lower.Article in Lithuanian

  5. Efficacy of virtual reality-based balance training versus the Biodex balance system training on the body balance of adults.

    Science.gov (United States)

    Ibrahim, Manal S; Mattar, Ayman G; Elhafez, Salam M

    2016-01-01

    [Purpose] This study investigated efficacy of virtual reality (VR)-based balance training on enhancing balance and postural reactions of adults as a low-cost new modality compared to the established Biodex Balance System (BBS). [Subjects] Thirty normal adults of both genders were divided randomly into two equal-sized experimental groups of 15: BBS balance training and VR balance training. [Methods] The training programmes were conducted in 12 sessions, three 15-min sessions per week. The Nintendo(®) Wii Fit Plus (NWFP) and its balance board were used to train of the VR group. Each participant answered a questionnaire concerning usability, enjoyment, balance improvement, and fatigue at the end of the training programs. [Results] The study found a significant increase the measure of mean overall balance (OLB) in both groups. No significant difference was found between the groups, but a significant decrease in the mean balance-test time was found for both groups, with no significant difference between the two training methods. The VR programme was rated highly enjoyable by 81.8% of the group. [Conclusion] The Wii Fit Plus system with the balance board as a new VR balance-training technique, can be considered an effective and enjoyable tool for the training of adults' body balance.

  6. Model Reduction for Nonlinear Systems by Incremental Balanced Truncation

    NARCIS (Netherlands)

    Besselink, Bart; van de Wouw, Nathan; Scherpen, Jacquelien M. A.; Nijmeijer, Henk

    2014-01-01

    In this paper, the method of incremental balanced truncation is introduced as a tool for model reduction of nonlinear systems. Incremental balanced truncation provides an extension of balanced truncation for linear systems towards the nonlinear case and differs from existing nonlinear balancing tech

  7. Model Reduction for Nonlinear Systems by Incremental Balanced Truncation

    NARCIS (Netherlands)

    Besselink, Bart; van de Wouw, Nathan; Scherpen, Jacquelien M. A.; Nijmeijer, Henk

    2014-01-01

    In this paper, the method of incremental balanced truncation is introduced as a tool for model reduction of nonlinear systems. Incremental balanced truncation provides an extension of balanced truncation for linear systems towards the nonlinear case and differs from existing nonlinear balancing tech

  8. Surface Energy Balance System (SEBS) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, D. R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    A Surface Energy Balance System (SEBS) has been installed collocated with each deployed Eddy Correlation Flux Measurement System (ECOR) at the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Southern Great Plains (SGP) site, North Slope of Alaska (NSA) site, first ARM Mobile Facility (AMF1), second ARM Mobile Facility (AMF2), and third ARM Mobile Facility (AMF3) at Oliktok Point (OLI). A SEBS was also deployed with the Tropical Western Pacific (TWP) site, before it was decommissioned. Data from these sites, including the retired TWP, are available in the ARM Data Archive. The SEBS consists of upwelling and downwelling solar and infrared radiometers within one net radiometer, a wetness sensor, and soil measurements. The SEBS measurements allow the comparison of ECOR sensible and latent heat fluxes with the energy balance determined from the SEBS and provide information on wetting of the sensors for data quality purposes.

  9. Battery Cell Balancing System and Method

    Science.gov (United States)

    Davies, Francis J. (Inventor)

    2014-01-01

    A battery cell balancing system is operable to utilize a relatively small number of transformers interconnected with a battery having a plurality of battery cells to selectively charge the battery cells. Windings of the transformers are simultaneously driven with a plurality of waveforms whereupon selected battery cells or groups of cells are selected and charged. A transformer drive circuit is operable to selectively vary the waveforms to thereby vary a weighted voltage associated with each of the battery cells.

  10. Accounting balance sheet as a system

    Directory of Open Access Journals (Sweden)

    Lukin Vladimir

    2016-04-01

    Full Text Available The article actualizes the need to study the systematic approach and accountants’ systematical thinking based on the analysis of the systems theory basic provisions, the applicability of the system properties to the "balance sheet" category and to explore the basic tenets of the existing schools of accounting. It is proved that the accounting is a complex socio-technical system; justified that the study of accounting from the perspective of a systematic approach will enable a better understanding of its structure, principles of functioning and the role of an accountant in its practical implementation.

  11. Balancing Hydronic Systems in Multifamily Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Ruch, Russell [Partnership for Advanced Residential Retrofit, Chicago, IL (United States); Ludwig, Peter [Partnership for Advanced Residential Retrofit, Chicago, IL (United States); Maurer, Tessa [Partnership for Advanced Residential Retrofit, Chicago, IL (United States)

    2014-07-01

    In multifamily hydronic systems, temperature imbalance may be caused by undersized piping, improperly adjusted balancing valves, inefficient water temperature and flow levels, and owner/occupant interaction with the boilers, distribution, and controls. The imbalance leads to tenant discomfort, higher energy use intensity, and inefficient building operation. This research, conducted by Building America team Partnership for Advanced Residential Retrofit, explores cost-effective distribution upgrades and balancing measures in multifamily hydronic systems, providing a resource to contractors, auditors, and building owners on best practices to improve tenant comfort and lower operating costs. The team surveyed existing knowledge on cost-effective retrofits for optimizing distribution in typical multifamily hydronic systems, with the aim of identifying common situations and solutions, and then conducted case studies on two Chicago area buildings with known balancing issues in order to quantify the extent of temperature imbalance. At one of these buildings a booster pump was installed on a loop to an underheated wing of the building. This study found that unit temperature in a multifamily hydronic building can vary as much as 61°F, particularly if windows are opened or tenants use intermittent supplemental heating sources like oven ranges. Average temperature spread at the building as a result of this retrofit decreased from 22.1°F to 15.5°F.

  12. Balancing Hydronic Systems in Multifamily Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Ruch, R.; Ludwig, P.; Maurer, T.

    2014-07-01

    In multifamily hydronic systems, temperature imbalance may be caused by undersized piping, improperly adjusted balancing valves, inefficient water temperature and flow levels, and owner/occupant interaction with the boilers, distribution and controls. The effects of imbalance include tenant discomfort, higher energy use intensity and inefficient building operation. This paper explores cost-effective distribution upgrades and balancing measures in multifamily hydronic systems, providing a resource to contractors, auditors, and building owners on best practices to improve tenant comfort and lower operating costs. The research was conducted by The Partnership for Advanced Residential Retrofit (PARR) in conjunction with Elevate Energy. The team surveyed existing knowledge on cost-effective retrofits for optimizing distribution in typical multifamily hydronic systems, with the aim of identifying common situations and solutions, and then conducted case studies on two Chicago area buildings with known balancing issues in order to quantify the extent of temperature imbalance. At one of these buildings a booster pump was installed on a loop to an underheated wing of the building. This study found that unit temperature in a multifamily hydronic building can vary as much as 61 degrees F, particularly if windows are opened or tenants use intermittent supplemental heating sources like oven ranges. Average temperature spread at the building as a result of this retrofit decreased from 22.1 degrees F to 15.5 degrees F.

  13. Directional and balancing selection in human beta-defensins

    Directory of Open Access Journals (Sweden)

    Armour John AL

    2008-04-01

    Full Text Available Abstract Background In primates, infection is an important force driving gene evolution, and this is reflected in the importance of infectious disease in human morbidity today. The beta-defensins are key components of the innate immune system, with antimicrobial and cell signalling roles, but also reproductive functions. Here we examine evolution of beta-defensins in catarrhine primates and variation within different human populations. Results We show that five beta-defensin genes that do not show copy number variation in humans show evidence of positive selection in catarrhine primates, and identify specific codons that have been under selective pressure. Direct haplotyping of DEFB127 in humans suggests long-term balancing selection: there are two highly diverged haplotype clades carrying different variants of a codon that, in primates, is positively selected. For DEFB132, we show that extensive diversity, including a four-state amino acid polymorphism (valine, isoleucine, alanine and threonine at position 93, is present in hunter-gatherer populations, both African and non-African, but not found in samples from agricultural populations. Conclusion Some, but not all, beta-defensin genes show positive selection in catarrhine primates. There is suggestive evidence of different selective pressures on these genes in humans, but the nature of the selective pressure remains unclear and is likely to differ between populations.

  14. Directional and balancing selection in human beta-defensins.

    Science.gov (United States)

    Hollox, Edward J; Armour, John A L

    2008-04-16

    In primates, infection is an important force driving gene evolution, and this is reflected in the importance of infectious disease in human morbidity today. The beta-defensins are key components of the innate immune system, with antimicrobial and cell signalling roles, but also reproductive functions. Here we examine evolution of beta-defensins in catarrhine primates and variation within different human populations. We show that five beta-defensin genes that do not show copy number variation in humans show evidence of positive selection in catarrhine primates, and identify specific codons that have been under selective pressure. Direct haplotyping of DEFB127 in humans suggests long-term balancing selection: there are two highly diverged haplotype clades carrying different variants of a codon that, in primates, is positively selected. For DEFB132, we show that extensive diversity, including a four-state amino acid polymorphism (valine, isoleucine, alanine and threonine at position 93), is present in hunter-gatherer populations, both African and non-African, but not found in samples from agricultural populations. Some, but not all, beta-defensin genes show positive selection in catarrhine primates. There is suggestive evidence of different selective pressures on these genes in humans, but the nature of the selective pressure remains unclear and is likely to differ between populations.

  15. Transcribing the balanced scorecard into system dynamics

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

    2013-01-01

    the cause-and-effect relationships of an integrated BSC model. Including dynamic aspects of BSCs into the discussion is only in its infancy, so the aim of our work is also to contribute to both scholars’ and practitioners’ general understanding of how such delayed dynamic effects propagate through system......The purpose of this paper is to show how a System Dynamics Modelling approach can be integrated into the Balanced Scorecard (BSC) for a case company with special focus on the handling of causality in a dynamic perspective. The BSC model includes five perspectives and a number of financial and non...

  16. Analysis of human standing balance by largest lyapunov exponent.

    Science.gov (United States)

    Liu, Kun; Wang, Hongrui; Xiao, Jinzhuang; Taha, Zahari

    2015-01-01

    The purpose of this research is to analyse the relationship between nonlinear dynamic character and individuals' standing balance by the largest Lyapunov exponent, which is regarded as a metric for assessing standing balance. According to previous study, the largest Lyapunov exponent from centre of pressure time series could not well quantify the human balance ability. In this research, two improvements were made. Firstly, an external stimulus was applied to feet in the form of continuous horizontal sinusoidal motion by a moving platform. Secondly, a multiaccelerometer subsystem was adopted. Twenty healthy volunteers participated in this experiment. A new metric, coordinated largest Lyapunov exponent was proposed, which reflected the relationship of body segments by integrating multidimensional largest Lyapunov exponent values. By using this metric in actual standing performance under sinusoidal stimulus, an obvious relationship between the new metric and the actual balance ability was found in the majority of the subjects. These results show that the sinusoidal stimulus can make human balance characteristics more obvious, which is beneficial to assess balance, and balance is determined by the ability of coordinating all body segments.

  17. Transcribing the balanced scorecard into system dynamics

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

    2013-01-01

    The purpose of this paper is to show how a System Dynamics Modelling approach can be integrated into the Balanced Scorecard (BSC) for a case company with special focus on the handling of causality in a dynamic perspective. The BSC model includes five perspectives and a number of financial and non......-financial measures. The overall idea of BSC is to make the strategy operational, as proposed by Kaplan and Norton (2007) and to use the strategy for simulation. Our results indicate that a company may gain great insight from simulation studies. The hypothesised model may be used as the first step in quantifying...... the cause-and-effect relationships of an integrated BSC model. Including dynamic aspects of BSCs into the discussion is only in its infancy, so the aim of our work is also to contribute to both scholars’ and practitioners’ general understanding of how such delayed dynamic effects propagate through system...

  18. Dynamic balance of unsymmetrical rotor-bearing system

    Institute of Scientific and Technical Information of China (English)

    黄森林; 刘占生; 苏杰先

    2003-01-01

    The formula is derived for calculating correction weights from motion equations of unsymmetrical ro-tor-bearing system. Two trial weights are required in two trial operations for ea ch balancing plane, and forwardprecession of trial responses are used to calculate the correction weights. Comparative experiments between thismethod and the conventional method are carried out on the test bench. Moreover, this method was used to bal-ance a 600 MW generator-bearing system, it decreased the balancing time and improved the balance accuracy.This method has been proved valid for balancing unsymmetrical rotor-bearing system.

  19. BALANCE

    Science.gov (United States)

    Carmichael, H.

    1953-01-01

    A torsional-type analytical balance designed to arrive at its equilibrium point more quickly than previous balances is described. In order to prevent external heat sources creating air currents inside the balance casing that would reiard the attainment of equilibrium conditions, a relatively thick casing shaped as an inverted U is placed over the load support arms and the balance beam. This casing is of a metal of good thernnal conductivity characteristics, such as copper or aluminum, in order that heat applied to one portion of the balance is quickly conducted to all other sensitive areas, thus effectively preventing the fornnation of air currents caused by unequal heating of the balance.

  20. Human genome and open source: balancing ethics and business.

    Science.gov (United States)

    Marturano, Antonio

    2011-01-01

    The Human Genome Project has been completed thanks to a massive use of computer techniques, as well as the adoption of the open-source business and research model by the scientists involved. This model won over the proprietary model and allowed a quick propagation and feedback of research results among peers. In this paper, the author will analyse some ethical and legal issues emerging by the use of such computer model in the Human Genome property rights. The author will argue that the Open Source is the best business model, as it is able to balance business and human rights perspectives.

  1. Procedure for Balancing an Air Distribution System with Decentralised Fans

    DEFF Research Database (Denmark)

    Gunner, Amalie; Hultmark, Göran; Vorre, Anders;

    2015-01-01

    This paper presents results from an on-going project concerning new design procedures for mechanical ventilation systems with low energy use. Conventional constant air volume (CAV) systems are usually balanced using flat plate dampers. The purpose of using balancing dampers is to intentionally...... flawed. This paper presents a new procedure for balancing of CAV systems in combination with decentralised fans. The new system was based on replacing the balancing dampers with decentralised fans. By replacing the balancing dampers with decentralised fans, airflows can be balanced by adjusting the speed...... of the fans. In conventional air distribution systems the fan provides the necessary pressure to overcome the resistance in the branch with the highest pressure resistance. This gives an unnecessary overpressure in the remaining branches that does not provide any useful purpose. In order to decrease the fan...

  2. NREL Offshore Balance-of-System Model

    Energy Technology Data Exchange (ETDEWEB)

    Maness, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Maples, Benjamin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Smith, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-01-01

    The U.S. Department of Energy (DOE) has investigated the potential for 20% of nationwide electricity demand to be generated from wind by 2030 and, more recently, 35% by 2050. Achieving this level of wind power generation may require the development and deployment of offshore wind technologies. DOE (2008) has indicated that reaching these 2030 and 2050 scenarios could result in approximately 10% and 20%, respectively, of wind energy generation to come from offshore resources. By the end of 2013, 6.5 gigawatts of offshore wind were installed globally. The first U.S. project, the Block Island Wind Farm off the coast of Rhode Island, has recently begun operations. One of the major reasons that offshore wind development in the United States is lagging behind global trends is the high capital expenditures required. An understanding of the costs and associated drivers of building a commercial-scale offshore wind plant in the United States will inform future research and help U.S. investors feel more confident in offshore wind development. In an effort to explain these costs, the National Renewable Energy Laboratory has developed the Offshore Balance-of-System model.

  3. Human Ensuing Self-balancing Automaton Based on Motion Sensor

    Directory of Open Access Journals (Sweden)

    R. Kishhanth

    2014-10-01

    Full Text Available Travel has become one among rudimentary necessities for every individual. Handling baggage plays an important role while travelling and for typical nomads it is cumbersome when heavy. With the proposed concept which will be dealt in this study, the baggage need not be pulled by us; it just follows us detecting our presence. Hence, the baggage is simply nothing but a robot. Prototype of motion sensor based human following robot that can balance itself in two wheels, thus behaving as a suitcase with intelligence and hence named Smart Suitcase. Concept of inverted pendulum helps in balancing. Regenerative power saving is established, when on its normal movement by the user wherein the saved power can be used for charging mobiles, laptops, torch lights etc. (low voltage applications. Passive infrared sensors fed with inbuilt intelligence in responding only to human presence helps this robot get even smarter.

  4. A Simplified Model of Human Alcohol Metabolism That Integrates Biotechnology and Human Health into a Mass Balance Team Project

    Science.gov (United States)

    Yang, Allen H. J.; Dimiduk, Kathryn; Daniel, Susan

    2011-01-01

    We present a simplified human alcohol metabolism model for a mass balance team project. Students explore aspects of engineering in biotechnology: designing/modeling biological systems, testing the design/model, evaluating new conditions, and exploring cutting-edge "lab-on-a-chip" research. This project highlights chemical engineering's impact on…

  5. A Simplified Model of Human Alcohol Metabolism That Integrates Biotechnology and Human Health into a Mass Balance Team Project

    Science.gov (United States)

    Yang, Allen H. J.; Dimiduk, Kathryn; Daniel, Susan

    2011-01-01

    We present a simplified human alcohol metabolism model for a mass balance team project. Students explore aspects of engineering in biotechnology: designing/modeling biological systems, testing the design/model, evaluating new conditions, and exploring cutting-edge "lab-on-a-chip" research. This project highlights chemical engineering's impact on…

  6. Recasting catchment water balance for water allocation between human and environmental purposes

    Directory of Open Access Journals (Sweden)

    S. Zhou

    2015-01-01

    Full Text Available Rebalancing water allocation between human consumptive uses and the environment in water catchments is a global challenge. The conventional water balance approach which partitions precipitation into evapotranspiration (ET and surface runoff supports the optimization of water allocations among different human water use sectors under the cap of water supply. However, this approach is unable to support the emerging water management priority issue of allocating water between societal and ecological systems. This paper recast the catchment water balance by partitioning catchment total ET into ET for the society and ET for the natural ecological systems, and estimated the impacts of water allocation on the two systems in terms of gross primary productivity (GPP, in the Murray–Darling Basin (MDB of Australia over the period 1900–2010. With the recast water balance, the more than 100 year water management in the MDB was divided into four periods corresponding to major changes in basin management: period 1 (1900–1956 expansion of water and land use by the societal system, period 2 (1956–1985 maximization of water and land use by the societal system, period 3 (1985–2002 maximization of water diversion for the societal system, and period 4 (2002–present rebalancing of water and land use between the societal and ecological systems. The recast water balance provided new understandings of the water and land dynamics between societal and ecological systems in the MDB, and it highlighted the experiences and lessons of catchment water management in the MDB over the last more than 100 years. The recast water balance could serve as the theoretical foundation for water allocation to keep a dynamic balance between the societal and ecological systems within a basin for sustainable catchment development. It provides a new approach to advance the discipline of socio-hydrology.

  7. INTEGRATION OF BALANCED SCORECARD AND QUALITY MANAGEMENT SYSTEM

    Directory of Open Access Journals (Sweden)

    Miroshnichenko M. A.

    2014-09-01

    Full Text Available The analysis and possibilities of use of the balanced scorecard for successful realization of corporate strategy are considered in this article. The most important results of research of integration of the quality management system in information system of the enterprise with use of the balanced scorecard are discussed

  8. A Dynamic Load Balancing Mechanism for Distributed Systems

    Institute of Scientific and Technical Information of China (English)

    蓝有然

    1996-01-01

    It is desirable in a distributed system to have the system load balanced evenly among the nodes so that the mean job response time is minimized.In this paper,we present a dynamic load balancing mechanism(DLB).It adopts a cntralized approach and is network topology independent.The DLB mechanism employs a set of threscholds which are automatically adjusted as the system load changes.It also provides a simple mechanism for the system to switch between periodic and instantaneous load balancing policies with ease.The performance of the proposed algorithm is evaluated by intensive simulations for various parameters.Te simulation results show that the mean job response time in a system implementing DLB algorithm is significantly lower than the same system without load balancings.Furthermore,compared with a previously proposed algorithm,DLB algorithm demonstrates improved performance,especially when the system is heavily loaded and the load is unevenly distributed.

  9. Energy-Storage Balanced Reduction of Port-Hamiltonian Systems

    NARCIS (Netherlands)

    Lopezlena, Ricardo; Scherpen, Jacquelien M.A.; Fujimoto, Kenji

    2003-01-01

    Supported by the framework of dissipativity theory, a procedure based on physical energy to balance and reduce port-Hamiltonian systems with collocated inputs and outputs is presented. Additionally, some relations with the methods of nonlinear balanced reduction are exposed. Finally a structure-pres

  10. The brain endocannabinoid system in the regulation of energy balance.

    Science.gov (United States)

    Richard, Denis; Guesdon, Benjamin; Timofeeva, Elena

    2009-02-01

    The role played by the endocannabinoid system in the regulation of energy balance is currently generating a great amount of interest among several groups of investigators. This interest in large part comes from the urgent need to develop anti-obesity and anti-cachexia drugs around target systems (such as the endocannabinoid system), which appears to be genuinely involved in energy balance regulation. When activated, the endocannabinoid system favors energy deposition through increasing energy intake and reducing energy expenditure. This system is activated in obesity and following food deprivation, which further supports its authentic function in energy balance regulation. The cannabinoid receptor type 1 (CB1), one of the two identified cannabinoid receptors, is expressed in energy-balance brain structures that are also able to readily produce or inactivate N-arachidonoyl ethanolamine (anandamide) and 2-arachidonoylglycerol (2AG), the most abundantly formed and released endocannabinoids. The brain action of endocannabinoid system on energy balance seems crucial and needs to be delineated in the context of the homeostatic and hedonic controls of food intake and energy expenditure. These controls require the coordinated interaction of the hypothalamus, brainstem and limbic system and it appears imperative to unravel those interplays. It is also critical to investigate the metabolic endocannabinoid system while considering the panoply of functions that the endocannabinoid system fulfills in the brain and other tissues. This article aims at reviewing the potential mechanisms whereby the brain endocannabinoid system influences the regulation energy balance.

  11. Balancing modern Power System with large scale of wind power

    DEFF Research Database (Denmark)

    Basit, Abdul; Altin, Müfit; Hansen, Anca Daniela

    2014-01-01

    Power system operators must ensure robust, secure and reliable power system operation even with a large scale integration of wind power. Electricity generated from the intermittent wind in large propor-tion may impact on the control of power system balance and thus deviations in the power system...... to be analysed with improved analytical tools and techniques. This paper proposes techniques for the active power balance control in future power systems with the large scale wind power integration, where power balancing model provides the hour-ahead dispatch plan with reduced planning horizon and the real time...... frequency in small or islanded power systems or tie line power flows in interconnected power systems. Therefore, the large scale integration of wind power into the power system strongly concerns the secure and stable grid operation. To ensure the stable power system operation, the evolving power system has...

  12. Targets of balancing selection in the human genome

    DEFF Research Database (Denmark)

    Andrés, Aida M; Hubisz, Melissa J; Indap, Amit

    2009-01-01

    to maintaining phenotypic variation in natural populations. Nevertheless, its prevalence and specific targets in the human genome remain largely unknown. We have analyzed the patterns of diversity and divergence of 13,400 genes in two human populations using an unbiased single-nucleotide polymorphism data set......, a genome-wide approach, and a method that incorporates demography in neutrality tests. We identified an unbiased catalog of genes with signatures of long-term balancing selection, which includes immunity genes as well as genes encoding keratins and membrane channels; the catalog also shows enrichment...... in functional categories involved in cellular structure. Patterns are mostly concordant in the two populations, with a small fraction of genes showing population-specific signatures of selection. Power considerations indicate that our findings represent a subset of all targets in the genome, suggesting...

  13. Balanced {C_4, C_5}-Quatrefoil Systems

    OpenAIRE

    USHIO, Kazuhiko

    2004-01-01

    In graph theory, the decomposition problems of graphs are very important topics. Various types of decompositions of many graphs can be seen in the literature of gaph theory. We give the necessary and sufficient condition for the existence of a balanced {C_4, C_5}-quatrefoil decomposition of K_n for each of (C_4, C_4, C_4, C_4)-quatrefoil, (C_4, C_4, C_4, C_5)-quatrefoil, (C_4, C_4, C_5, C_5)-quatrefoil, (C_4, C_5, C_5, C_5)-quatrefoil, and (C_5, C_5, C_5, C_5)-quatrefoil. These decompositions...

  14. Noise-induced phase transition in the model of human virtual stick balancing

    CERN Document Server

    Zgonnikov, Arkady

    2016-01-01

    Humans face the task of balancing dynamic systems near an unstable equilibrium repeatedly throughout their lives. Much research has been aimed at understanding the mechanisms of intermittent control in the context of human balance control. The present paper deals with one of the recent developments in the theory of human intermittent control, namely, the double-well model of noise-driven control activation. We demonstrate that the double-well model can reproduce the whole range of experimentally observed distributions under different conditions. Moreover, we show that a slight change in the noise intensity parameter leads to a sudden shift of the action point distribution shape, that is, a phase transition is observed.

  15. Perceptual and motor learning underlies human stick-balancing skill.

    Science.gov (United States)

    Lee, Kwee-Yum; O'Dwyer, Nicholas; Halaki, Mark; Smith, Richard

    2015-01-01

    We investigated the acquisition of skill in balancing a stick (52 cm, 34 g) on the fingertip in nine participants using three-dimensional motion analysis. After 3.5 h of practice over 6 wk, the participants could more consistently balance the stick for longer durations with greatly reduced magnitude and speed of stick and finger movements. Irrespective of level of skill, the balanced stick behaved like a normal noninverted pendulum oscillating under greater-than-gravity torque with simple harmonic motion about a virtual pivot located at the radius of gyration above the center of mass. The control input parameter was the magnitude ratio between the torque applied on the stick by the participant and the torque due to gravity. The participants utilized only a narrow range of this parameter, which did not change with practice, to rotate the stick like a linear mass-spring system. With increased skill, the stick therefore maintained the same period of oscillation but showed marked reductions in magnitude of both oscillation and horizontal translation. Better balancing was associated with 1) more accurate visual localization of the stick and proprioceptive localization of the finger and 2) reduced cross-coupling errors between finger and stick movements in orthogonal directions; i.e., finger movements in the anteroposterior plane became less coupled with stick tip movements in the mediolateral plane, and vice versa. Development of this fine motor skill therefore depended on perceptual and motor learning to provide improved estimation of sensorimotor state and precision of motor commands to an unchanging internal model of the rotational dynamics.

  16. Use of the Microsoft Kinect system to characterize balance ability during balance training.

    Science.gov (United States)

    Lim, Dohyung; Kim, ChoongYeon; Jung, HoHyun; Jung, Dukyoung; Chun, Keyoung Jin

    2015-01-01

    The risk of falling increases significantly in the elderly because of deterioration of the neural musculature regulatory mechanisms. Several studies have investigated methods of preventing falling using real-time systems to evaluate balance; however, it is difficult to monitor the results of such characterizations in real time. Herein, we describe the use of Microsoft's Kinect depth sensor system to evaluate balance in real time. Six healthy male adults (25.5±1.8 years, 173.9±6.4 cm, 71.4±6.5 kg, and 23.6±2.4 kg/m(2)), with normal balance abilities and with no musculoskeletal disorders, were selected to participate in the experiment. Movements of the participants were induced by controlling the base plane of the balance training equipment in various directions. The dynamic motion of the subjects was measured using two Kinect depth sensor systems and a three-dimensional motion capture system with eight infrared cameras. The two systems yielded similar results for changes in the center of body mass (P>0.05) with a large Pearson's correlation coefficient of γ>0.60. The results for the two systems showed similarity in the mean lower-limb joint angle with flexion-extension movements, and these values were highly correlated (hip joint: within approximately 4.6°; knee joint: within approximately 8.4°) (0.400.05). Large differences with a low correlation were, however, observed for the lower-limb joint angle in relation to abduction-adduction and internal-external rotation motion (γKinect system in balance training by measuring changes in the center of body mass and flexion-extension movements of the lower limbs, but not abduction-adduction and internal-external rotation.

  17. Information system quality in work-life balance

    Directory of Open Access Journals (Sweden)

    Sharmini Gopinathan

    2016-06-01

    Full Text Available This paper aims to look for the role information systems quality may play in work-life balance among Malaysian ICT employees. The results of this study will be useful in the development of new tools and technologies that are focused on ISQ dimensions primarily information system quality which can be helpful to devise suggestions to the ICT sector on matters pertaining to sustainable development/policy formulation with reference to achieving a good work-life balance. A total of 79 respondents’ views were analyzed using Partial Least Square (PLS to obtain the final results. The results showed that information quality and system quality has strong effect on work-life balance as compared to service quality which showed no relation to work-life balance.

  18. Balancing modern Power System with large scale of wind power

    OpenAIRE

    Basit, Abdul; Altin, Müfit; Hansen, Anca Daniela; Sørensen, Poul Ejnar

    2014-01-01

    Power system operators must ensure robust, secure and reliable power system operation even with a large scale integration of wind power. Electricity generated from the intermittent wind in large propor-tion may impact on the control of power system balance and thus deviations in the power system frequency in small or islanded power systems or tie line power flows in interconnected power systems. Therefore, the large scale integration of wind power into the power system strongly concerns the s...

  19. Experimental neck muscle pain impairs standing balance in humans

    CERN Document Server

    Vuillerme, Nicolas; 10.1007/s00221-008-1639-7

    2009-01-01

    Impaired postural control has been reported in patients with chronic neck pain of both traumatic and non-traumatic etiologies, but whether painful stimulation of neck muscle per se can affect balance control during quiet standing in humans remains unclear. The purpose of the present experiment was thus to investigate the effect of experimental neck muscle pain on standing balance in young healthy adults. To achieve this goal, 16 male university students were asked to stand upright as still as possible on a force platform with their eyes closed in two conditions of No pain and Pain of the neck muscles elicited by experimental painful electrical stimulation. Postural control and postural performance were assessed by the displacements of the center of foot pressure (CoP) and of the center of mass (CoM), respectively. The results showed increased CoP and CoM displacements variance, range, mean velocity, and mean and median frequencies in the Pain relative to the No pain condition. The present findings emphasize t...

  20. HUMAN RESOURCE ASSESSMENT, RECOGNITION, AND REWARD WITH A BALANCED SCORECARD APPROACH

    OpenAIRE

    Mehran Nejati; Sasan Ghasemi; Azadeh Shafaei

    2007-01-01

    This article develops a method that serves the team leaders and executive managers as a guide for assuring the accomplishment of the team’s objectives. It spotlights the trend of human resource performance. The method introduced in this article focuses on Balanced Scorecard (BSC) as a revolutionizing tool in the management of performance and suggests a new and scientific way for assessment, recognition, and reward system. The innovative model introduced in this article can be used to evaluate...

  1. Patenting human pluripotent cells: balancing commercial, academic and ethical interests.

    Science.gov (United States)

    Bahadur, G; Morrison, M

    2010-01-01

    The article addresses the issue of the ethics of patenting in human embryonic stem (hES) cells. The current stance of the European Patent Office in citing moral objections to patents on hES cells and the monopolistic scope of the Wisconsin Research Alumni Fund/Geron patents granted by the United States Patent and Trademark Office represent twin obstacles to achieving an ethical balance in patent rights in this field. The particular issues and strategies around granting patents on hES cells can be better understood by placing them in the context of the biotechnology industry and its role in the global bioeconomy. Some possible avenues of redress are considered based on the potential to open up cell pluripotency as new terrain for intellectual property offered by new technological breakthroughs such as induced pluripotent cells. Any changes in patent law should be accompanied by increased collaboration through devices such as patent pools.

  2. Local Balancing System from the Business Model Canvas Perspective

    Directory of Open Access Journals (Sweden)

    Matusiak Bożena Ewa

    2016-01-01

    Full Text Available The paper presents an overall view of the business model (BM for the e-balance system for: balancing energy production and consumption in energy efficient, smart neighbourhoods (the e-balance project, FP7-SMARTCITIES-2013 along with its functionalities, based upon the Osterwalder’s canvas methodology. Additionally, this is the second, after two years of work, more incisive evaluation of the BM from the user’s and demo site’s perspective (Bronsbergen, the Netherlands. The aim of this paper is to present results and assess the above mentioned BM in the face its commercialisation and applicability to Europe.

  3. BETWEEN BALANCED SCORECARD AND QUALITY MANAGEMENT SYSTEM

    Directory of Open Access Journals (Sweden)

    Jelena Jovanović

    2008-09-01

    Full Text Available The aim of this research is to analyze parallel implementation of BSC as a strategic management system and quality management system by the principals of ISO 9000 certification. We will analyze advantages and disadvantages of the models. Further more, the research will analyze cumulative advantages of the two systems implementation. The research will present possibilities for BSC implementation in QMS environment, underlining the processes. We will put the accent on improvement of firm's effectiveness by Strategic Management System (BSC and Quality Management System's implementation.

  4. Projection-free approximate balanced truncation of large unstable systems

    Science.gov (United States)

    Flinois, Thibault L. B.; Morgans, Aimee S.; Schmid, Peter J.

    2015-08-01

    In this article, we show that the projection-free, snapshot-based, balanced truncation method can be applied directly to unstable systems. We prove that even for unstable systems, the unmodified balanced proper orthogonal decomposition algorithm theoretically yields a converged transformation that balances the Gramians (including the unstable subspace). We then apply the method to a spatially developing unstable system and show that it results in reduced-order models of similar quality to the ones obtained with existing methods. Due to the unbounded growth of unstable modes, a practical restriction on the final impulse response simulation time appears, which can be adjusted depending on the desired order of the reduced-order model. Recommendations are given to further reduce the cost of the method if the system is large and to improve the performance of the method if it does not yield acceptable results in its unmodified form. Finally, the method is applied to the linearized flow around a cylinder at Re = 100 to show that it actually is able to accurately reproduce impulse responses for more realistic unstable large-scale systems in practice. The well-established approximate balanced truncation numerical framework therefore can be safely applied to unstable systems without any modifications. Additionally, balanced reduced-order models can readily be obtained even for large systems, where the computational cost of existing methods is prohibitive.

  5. Architectural Review of Load Balancing Single System Image

    Directory of Open Access Journals (Sweden)

    B. S. Ahmed

    2008-01-01

    Full Text Available Problem statement: With the growing popularity of clustering application combined with apparent usability, the single system image is in the limelight and actively studied as an alternative solution for computational intensive applications as well as the platform for next evolutionary grid computing era. Approach: Existing researches in this field concentrated on various features of Single System Images like file system and memory management. However, an important design consideration for this environment is load allocation and balancing that is usually handled by an automatic process migration daemon. Literature shows that the design concepts and factors that affect the load balancing feature in an SSI system are not clear. Result: This study will review some of the most popular architecture and algorithms used in load balancing single system image. Various implementations from the past to present will be presented while focusing on the factors that affect the performance of such system. Conclusion: The study showed that although there are some successful open source systems, the wide range of implemented systems investigated that research activity should concentrate on the systems that have already been proposed and proved effectiveness to achieve a high quality load balancing system.

  6. Auto white balance method using a pigmentation separation technique for human skin color

    Science.gov (United States)

    Tanaka, Satomi; Kakinuma, Akihiro; Kamijo, Naohiro; Takahashi, Hiroshi; Tsumura, Norimichi

    2017-02-01

    The human visual system maintains the perception of colors of an object across various light sources. Similarly, current digital cameras feature an auto white balance function, which estimates the illuminant color and corrects the color of a photograph as if the photograph was taken under a certain light source. The main subject in a photograph is often a person's face, which could be used to estimate the illuminant color. However, such estimation is adversely affected by differences in facial colors among individuals. The present paper proposes an auto white balance algorithm based on a pigmentation separation method that separates the human skin color image into the components of melanin, hemoglobin and shading. Pigment densities have a uniform property within the same race that can be calculated from the components of melanin and hemoglobin in the face. We, thus, propose a method that uses the subject's facial color in an image and is unaffected by individual differences in facial color among Japanese people.

  7. Auto white balance method using a pigmentation separation technique for human skin color

    Science.gov (United States)

    Tanaka, Satomi; Kakinuma, Akihiro; Kamijo, Naohiro; Takahashi, Hiroshi; Tsumura, Norimichi

    2016-11-01

    The human visual system maintains the perception of colors of an object across various light sources. Similarly, current digital cameras feature an auto white balance function, which estimates the illuminant color and corrects the color of a photograph as if the photograph was taken under a certain light source. The main subject in a photograph is often a person's face, which could be used to estimate the illuminant color. However, such estimation is adversely affected by differences in facial colors among individuals. The present paper proposes an auto white balance algorithm based on a pigmentation separation method that separates the human skin color image into the components of melanin, hemoglobin and shading. Pigment densities have a uniform property within the same race that can be calculated from the components of melanin and hemoglobin in the face. We, thus, propose a method that uses the subject's facial color in an image and is unaffected by individual differences in facial color among Japanese people.

  8. The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.

    Science.gov (United States)

    Uno, Kaname; Kato, Katsuaki; Kusaka, Gen; Asano, Naoki; Iijima, Katsunori; Shimosegawa, Tooru

    2011-10-01

    Oxidative stress might participate in the carcinogenesis of human esophageal squamous cell carcinomas (hESCC). 4-Hydroxynonenal (HNE) is a major product of membrane lipid peroxidation with short life. It might act as an important mediator through the generation of adducts and activate epidermal growth factor receptor (EGFR) signaling. It is mainly trapped with glutathione (GSH) and catalyzed by glutathione S-transferases (GSTs). This study aimed to elucidate the possible participation of HNE, GSH/GST system, and EGFR signaling in hESCC development. Immunohistochemistry of HNE adducts, EGFR, and phosphorylated EGFR (pEGFR) was performed with hESCC specimens. The effect of HNE on the phosphorylation of EGFR and its downstream PhospholipaseCγ1 (PLCγ1) was investigated with KYSE30 cell-line. Pretreatment with GSH inducer N-acetylcysteine (NAC) or GSH inhibitor Buthionine sulfoximine (BSO) and mandatory transfection of hGSTA4 gene in KYSE30 were conducted to investigate the relationship between HNE and GSH/GST system. Immunoreactants of HNE adducts, EGFR, and pEGFR were increased in hESCC compared to non-cancerous epithelium with positive correlations. The treatment of HNE ligand-independently induced the phosphorylation of EGFR and PLCγ1 accompanying the diminishment of intracellular GSH level. NAC increased GSH contents but BSO decreased in dose-dependent manners. Reflecting changes in GSH, HNE-induced EGFR phosphorylation was suppressed by NAC, whereas it was promoted by BSO. Mandatory expression of hGSTA4 suppressed HNE-induced events. We first demonstrated that the ligand-independent activation of EGFR by the balance between the stimulation of HNE and the prevention of intrinsic GSH/GST system might participate in the development of hESCC.

  9. FACTORS OF STEADY AND BALANCED DEVELOPMENT OF REGIONAL ECONOMIC SYSTEMS

    Directory of Open Access Journals (Sweden)

    Polidi A. A.

    2016-03-01

    Full Text Available The article proves the need of identification and classification of the most relevant factors of the sustainable balanced development of the regional economic system (RES. Substantial filling of the category "sustainable balanced development" which is accepted within the real research is designated. On the basis of the analysis of the classifications of factors of the sustainable balanced development of economy of the region presented in scientific literature their discrepancy modern is established to conditions of globalization of the economy causing increase of a role of foreign economic activity of territorial subjects of the Russian Federation in ensuring their long-term competitiveness. Proceeding from the last, within the classification of factors of the sustainable balanced development of RES offered by authors the following their groups are allocated: global, national, regional. For each of the designated groups we substantiated the set of relevant factors

  10. The Study On Load Balancing Strategies In Distributed Computing System

    Directory of Open Access Journals (Sweden)

    Md. Firoj Ali

    2012-05-01

    Full Text Available A number of load balancing algorithms were developed in order to improve the execution of a distributed application in any kind of distributed architecture. Load balancing involves assigning tasks to each processor and minimizing the execution time of the program. In practice, it would be possible even to execute the applications on any machine of worldwide distributed systems. However, the ‘distributed system’ becomes popular and attractive with the introduction of the web. This results in a significant performance improvement for the users. This paper describes the necessary, newly developed, principal concepts for several load balancing techniques in a distributed computing environment. This paper also includes various types of load balancing strategies, their merits, demerits and comparison depending on certain parameters.

  11. DESIGNING COMPANY PERFORMANCE MEASUREMENT SYSTEM USING BALANCE SCORECARD APPROACH

    Directory of Open Access Journals (Sweden)

    Cecep Mukti Soleh

    2015-05-01

    Full Text Available This research aimed to design how to measure company performance by using balance scorecard approach in coal transportation services industry. Depth interview was used to obtain qualitative data determination of strategic objectives, key performance indicators, strategic initiatives, and in charge units for each balanced scorecard perspectives while the quantitative data were obtained from weighting through questionnaires and analyzed using paired comparison to get a perspective what mostly affected the performance of the company. To measure the achievement of corporate performance, each KPI used (1 the scoring system with the methods that higher is better, lower is better and precise is better; (2 traffic light system with the help of green, yellow, red for identification of target achievement. This research result shows that in the balance scorecard perspective, the most influences on the overall performance of the company include the customer's perspective (31%, financial perspective (29%, internal business processes (21%, learning, and growth 19%. Keywords: balance scorecard, paired comparison, coal transportation serviceABSTRAKPenelitian ini bertujuan untuk merancang pengukuran kinerja perusahaan dengan menggunakan pendekatan balance scorecard di industri jasa pengangkutan batu bara. Data kualitatif diperoleh melalui indepth interview digunakan untuk menentukan sasaran strategik, indikator kinerja utama, inisiatif strategi dan penanggungjawab setiap divisi setiap perspektif balance scorecard, sedangkan data kuantitatif digunakan untuk pembobotan melalui kuesioner dan dianalisis dengan menggunakan metode paired comparisson untuk mendapatkan perspektif yang paling berpengaruh terhadap kinerja perusahaan. Ukuran pencapaian kinerja perusahaan dari setiap KPI menggunakan; (1 scoring system dengan bantuan metode higher is better, lower is better dan precise is better;(2 traffic light system dengan menggunakan bantuan warna hijau, kuning, merah

  12. Singular Value Analysis and Balanced Realizations for Nonlinear Systems

    NARCIS (Netherlands)

    Fujimoto, Kenji; Scherpen, Jacquelien M.A.; Rommes, Joost; Schilders, Wilhelmus H.A.; Vorst, Henk A. van der

    2008-01-01

    For linear control systems minimal realization theory and the related model reduction methods play a crucial role in understanding and handling the system. These methods are well established and have proved to be very successful. In particular the method called balanced truncation gives a good

  13. Human Resource Accounting System

    Science.gov (United States)

    Cerullo, Michael J.

    1974-01-01

    Main objectives of human resource accounting systems are to satisfy the informational demands made by investors and by operating managers. The paper's main concern is with the internal uses of a human asset system. (Author)

  14. FERTILIZER RECOMMENDATION SYSTEM FOR MELON BASED ON NUTRITIONAL BALANCE

    Directory of Open Access Journals (Sweden)

    José Aridiano Lima de Deus

    2015-04-01

    Full Text Available Melon is one of the most demanding cucurbits regarding fertilization, requiring knowledge of soils, crop nutritional requirements, time of application, and nutrient use efficiency for proper fertilization. Developing support systems for decision-making for fertilization that considers these variables in nutrient requirement and supply is necessary. The objective of this study was parameterization of a fertilizer recommendation system for melon (Ferticalc-melon based on nutritional balance. To estimate fertilizer recommendation, the system considers the requirement subsystem (REQ, which includes the demand for nutrients by the plant, and the supply subsystem (SUP, which corresponds to the supply of nutrients through the soil and irrigation water. After determining the REQtotal and SUPtotal, the system calculates the nutrient balances for N, P, K, Ca, Mg, and S, recommending fertilizer application if the balance is negative (SUP < REQ, but not if the balance is positive or zero (SUP ≥ REQ. Simulations were made for different melon types (Yellow, Cantaloupe, Galia and Piel-de-sapo, with expected yield of 45 t ha-1. The system estimated that Galia type was the least demanding in P, while Piel-de-sapo was the most demanding. Cantaloupe was the least demanding for N and Ca, while the Yellow type required less K, Mg, and S. As compared to other fertilizer recommendation methods adopted in Brazil, the Ferticalc system was more dynamic and flexible. Although the system has shown satisfactory results, it needs to be evaluated under field conditions to improve its recommendations.

  15. Human Resource Management System

    OpenAIRE

    Navaz, A. S. Syed; Fiaz, A. S. Syed; Prabhadevi, C.; V.Sangeetha; Gopalakrishnan,S.

    2013-01-01

    The paper titled HUMAN RESOURCE MANAGEMENT SYSTEM is basically concerned with managing the Administrator of HUMAN RESOURCE Department in a company. A Human Resource Management System, refers to the systems and processes at the intersection between human resource management and information technology. It merges HRM as a discipline and in particular its basic HR activities and processes with the information technology field, whereas the programming of data processing systems evolved into standa...

  16. Novel load balancing DHT scheme for the heterogeneous system

    Institute of Scientific and Technical Information of China (English)

    Li Yujun; Lu Xianliang; Hou Mengshu

    2008-01-01

    The capacities of the nodes in the peer-to-peer system are strongly heterogeneous,hence one can benefit from distributing the load.based on the capacity of the nodes.At first a model is discussed to evaluate the load balancing of the heterogeneous system,and then a novel load balancing scheme is proposed based on the concept of logical servers and the randomized binary tree,and theoretical guarantees are given.Finally,the feasibility of the scheme using extensive simulations is proven.

  17. Simulation model of load balancing in distributed computing systems

    Science.gov (United States)

    Botygin, I. A.; Popov, V. N.; Frolov, S. G.

    2017-02-01

    The availability of high-performance computing, high speed data transfer over the network and widespread of software for the design and pre-production in mechanical engineering have led to the fact that at the present time the large industrial enterprises and small engineering companies implement complex computer systems for efficient solutions of production and management tasks. Such computer systems are generally built on the basis of distributed heterogeneous computer systems. The analytical problems solved by such systems are the key models of research, but the system-wide problems of efficient distribution (balancing) of the computational load and accommodation input, intermediate and output databases are no less important. The main tasks of this balancing system are load and condition monitoring of compute nodes, and the selection of a node for transition of the user’s request in accordance with a predetermined algorithm. The load balancing is one of the most used methods of increasing productivity of distributed computing systems through the optimal allocation of tasks between the computer system nodes. Therefore, the development of methods and algorithms for computing optimal scheduling in a distributed system, dynamically changing its infrastructure, is an important task.

  18. Directional sensitivity of "first trial" reactions in human balance control.

    NARCIS (Netherlands)

    Oude Nijhuis, L.B.; Allum, J.H.J.; Borm, G.F.; Honegger, F.; Overeem, S.; Bloem, B.R.

    2009-01-01

    Support-surface movements are commonly used to examine balance control. Subjects typically receive a series of identical or randomly interspersed multidirectional balance perturbations and the atypical "first trial reaction" (evoked by the first perturbation) is often excluded from further analysis.

  19. Increasing cropping system diversity balances productivity, profitability and environmental health

    Science.gov (United States)

    Balancing productivity, profitability, and environmental health is a key challenge for agricultural sustainability. Most crop production systems in the United States are characterized by low species and management diversity, high use of fossil energy and agrichemicals, and can have large negative im...

  20. Balance laws and centro velocity in dissipative systems

    NARCIS (Netherlands)

    Groesen, van E.; Mainardi, F.

    1990-01-01

    Starting with a density that is conserved for a dynamical system when dissipation is ignored, a local conservation law is derived for which the total flux (integrated over the spatial domain) is unique. When dissipation is incorporated, the conservation law becomes a balance law. The contribution du

  1. Balance laws and centro velocity in dissipative systems

    NARCIS (Netherlands)

    van Groesen, Embrecht W.C.; Mainardi, F.

    1990-01-01

    Starting with a density that is conserved for a dynamical system when dissipation is ignored, a local conservation law is derived for which the total flux (integrated over the spatial domain) is unique. When dissipation is incorporated, the conservation law becomes a balance law. The contribution

  2. A strategy for load balancing in distributed storage systems

    CERN Document Server

    CERN. Geneva

    2012-01-01

    Distributed storage systems are critical to the operation of the WLCG. These systems are not limited to fulfilling the long term storage requirements. They also serve data for computational analysis and other computational jobs. Distributed storage systems provide the ability to aggregate the storage and IO capacity of disks and tapes, but at the end of the day IO rate is still bound by the capabilities of the hardware, in particular the hard drives. Throughput of hard drives has increased dramatically over the decades, however for computational analysis IOPS is typically the limiting factor. To maximize return of investment, balancing IO load over available hardware is crucial. The task is made complicated by the common use of heterogeneous hardware and software environments that results from combining new and old hardware into a single storage system. This paper describes recent advances made in load balancing in the dCache distributed storage system. We describe a set of common requirements for load balan...

  3. Design of Upper Computer Software of Human Balance Function Evaluation and Training System%人体平衡功能评估训练系统上位机软件设计

    Institute of Scientific and Technical Information of China (English)

    凌徵华; 谢叻; 毛志勇; 蔡楷; 蔡萍; 蒲放

    2013-01-01

    Objective: To assess body balance function objectively and quantitatively, which can assist the doctor diagnose diseases according to the patient's balance ability effectively. Methods: Develop the software with visual studio and c # based on the needs of physicians and the hardware. Results:The system realizes real-time display of information about balance function, including both the COM(center of mass) and plantar pressure distribution. It can also manage the patient's information, store test results and print test report. Furthermore, rehabilitation training games can help patients train their balance function. Conclusion: This system can help doctors assess the patient's balance ability to provide a basis for the diagnosis, while contributing to patient rehabilitation training.%目的:客观、定量地评定人体平衡功能,有效地协助医生根据病人的平衡能力诊断疾病。方法:了解医生的需求,然后结合硬件在visual studio c#环境下进行开发。结果:该系统能实时显示被测试者的重心摇摆轨迹和足底压力分布,测试结束后计算出平衡能力的评估指标,并实现病人的信息管理、检测结果的存储与检测报告的打印。同时康复训练游戏可以帮助病人训练平衡能力。结论:该系统能帮助医生评估病人的平衡能力,为诊断提供依据,同时能提高病人康复训练的趣味性。

  4. Comparison of the balance accelerometer measure and balance error scoring system in adolescent concussions in sports.

    Science.gov (United States)

    Furman, Gabriel R; Lin, Chia-Cheng; Bellanca, Jennica L; Marchetti, Gregory F; Collins, Michael W; Whitney, Susan L

    2013-06-01

    High-technology methods demonstrate that balance problems may persist up to 30 days after a concussion, whereas with low-technology methods such as the Balance Error Scoring System (BESS), performance becomes normal after only 3 days based on previously published studies in collegiate and high school athletes. To compare the National Institutes of Health's Balance Accelerometer Measure (BAM) with the BESS regarding the ability to detect differences in postural sway between adolescents with sports concussions and age-matched controls. Cohort study (diagnosis); Level of evidence, 2. Forty-three patients with concussions and 27 control participants were tested with the standard BAM protocol, while sway was quantified using the normalized path length (mG/s) of pelvic accelerations in the anterior-posterior direction. The BESS was scored by experts using video recordings. The BAM was not able to discriminate between healthy and concussed adolescents, whereas the BESS, especially the tandem stance conditions, was good at discriminating between healthy and concussed adolescents. A total BESS score of 21 or more errors optimally identified patients in the acute concussion group versus healthy participants at 60% sensitivity and 82% specificity. The BAM is not as effective as the BESS in identifying abnormal postural control in adolescents with sports concussions. The BESS, a simple and economical method of assessing postural control, was effective in discriminating between young adults with acute concussions and young healthy people, suggesting that the test has value in the assessment of acute concussions.

  5. Evaluation of surface energy and radiation balance systems for FIFE

    Science.gov (United States)

    Fritschen, Leo J.; Qian, Ping

    1988-01-01

    The energy balance and radiation balance components were determined at six sites during the First International Satellite Land Surface Climatology Project Field Experiment (FIFE) conducted south of Manhattan, Kansas during the summer of 1987. The objectives were: to determine the effect of slope and aspect, throughout a growing season, on the magnitude of the surface energy balance fluxes as determined by the Energy Balance Method (EBM); to investigate the calculation of the soil heat flux density at the surface as calculated from the heat capacity and the thermal conductivity equations; and to evaluate the performance of the Surface Energy and Radiation Balance System (SERBS). A total of 17 variables were monitored at each site. They included net, solar (up and down), total hemispherical (up and down), and diffuse radiation, soil temperature and heat flux density, air and wet bulb temperature gradients, wind speed and direction, and precipitation. A preliminary analysis of the data, for the season, indicate that variables including net radiation, air temperature, vapor pressure, and wind speed were quite similar at the sites even though the sites were as much as 16 km apart and represented four cardinal slopes and the top of a ridge.

  6. Procedure for Balancing an Air Distribution System with Decentralised Fans

    DEFF Research Database (Denmark)

    Gunner, Amalie; Hultmark, Göran; Vorre, Anders

    2015-01-01

    of the fans. In conventional air distribution systems the fan provides the necessary pressure to overcome the resistance in the branch with the highest pressure resistance. This gives an unnecessary overpressure in the remaining branches that does not provide any useful purpose. In order to decrease the fan......This paper presents results from an on-going project concerning new design procedures for mechanical ventilation systems with low energy use. Conventional constant air volume (CAV) systems are usually balanced using flat plate dampers. The purpose of using balancing dampers is to intentionally...... pressure requirements the fan was dimensioned for the branch with the least pressure resistance. The decentralised fans then provided sufficient pressure to overcome the exact resistance in the corresponding branch. The results show that by using decentralised fans in duct systems instead of dampers...

  7. An Efficient Diffusion Load Balancing Algorithm in Distributed System

    Directory of Open Access Journals (Sweden)

    Rafiqul Z. Khan

    2014-07-01

    Full Text Available In distributed computing system some nodes are very fast and some are slow and during the computation many fast nodes become idle or under loaded while the slow nodes become over loaded due to the uneven distribution of load in the system. In distributed system, the most common important factor is the information collection about loads on different nodes. The success of load balancing algorithm depends on how quickly the information about the load in the system is collected by a node willing to transfer or accept load. In this paper we have shown that the number of communication overheads depends on the number of overloaded nodes present in the domain of an under loaded nodes and vice-versa. We have also shown that communication overhead for load balancing is always fairly less than KN but in worst case our algorithm’s complexity becomes equal to KN.

  8. Capillary Action may Cool Systems and Precisely balance Chemical Reactions

    Science.gov (United States)

    Kriske, Richard

    2011-10-01

    It is well known that it takes no work for Water to rise in a Capillary tube against the force of Gravity. There is a precise balance in this system that resembles Robert Millikan's ``Oil Drop'' experiment, where mass was balanced against the electrostatic force. If at the top of the capillary tube there is evaporation, one can see that the system is cooled as another water molecule has room to move up the column. Furthermore, if the evaporation process can be controlled one photon at a time, a precise balance is created between a photon, and the height/mass of the column. If other molecules are place in the column, they can be moved up and down the column, in a chromatograph way, in a fairly precise manner, by controlling evaporation and molecular weight. If in addition to all of this, the interface of the solution against the walls of the column have Fermi levels, it can be seen as a very precise Electrochemical Device. In the situation of nanotubes, as opposed to trees and plants, these properties can be used to create measure environmental properties and to Balance Chemical Reactions. Forests, and Plants may cool themselves and their environment using this process, and using this process coupled with more energetic photons through photosynthesis.

  9. HUMAN RESOURCE ASSESSMENT, RECOGNITION, AND REWARD WITH A BALANCED SCORECARD APPROACH

    Directory of Open Access Journals (Sweden)

    Mehran Nejati

    2007-10-01

    Full Text Available This article develops a method that serves the team leaders and executive managers as a guide for assuring the accomplishment of the team’s objectives. It spotlights the trend of human resource performance. The method introduced in this article focuses on Balanced Scorecard (BSC as a revolutionizing tool in the management of performance and suggests a new and scientific way for assessment, recognition, and reward system. The innovative model introduced in this article can be used to evaluate personnel’s performance, rank them, set job-related targets, and motivate them to improve their performance.

  10. A novel load balancing method for hierarchical federation simulation system

    Science.gov (United States)

    Bin, Xiao; Xiao, Tian-yuan

    2013-07-01

    In contrast with single HLA federation framework, hierarchical federation framework can improve the performance of large-scale simulation system in a certain degree by distributing load on several RTI. However, in hierarchical federation framework, RTI is still the center of message exchange of federation, and it is still the bottleneck of performance of federation, the data explosion in a large-scale HLA federation may cause overload on RTI, It may suffer HLA federation performance reduction or even fatal error. Towards this problem, this paper proposes a load balancing method for hierarchical federation simulation system based on queuing theory, which is comprised of three main module: queue length predicting, load controlling policy, and controller. The method promotes the usage of resources of federate nodes, and improves the performance of HLA simulation system with balancing load on RTIG and federates. Finally, the experiment results are presented to demonstrate the efficient control of the method.

  11. Balance impairment in people with multiple sclerosis: preliminary evidence for the Balance Evaluation Systems Test.

    Science.gov (United States)

    Jacobs, Jesse V; Kasser, Susan L

    2012-07-01

    This study examined the validity of the Balance Evaluation Systems Test (BESTest) to identify balance impairments in people with multiple sclerosis (MS) by evaluating differences in BESTest performance between people with and without MS. We also assessed the BESTest's validity by correlation with objective measures of postural performance as well as with disease severity and fall status. Thirteen subjects with MS (Expanded Disability Status Scale; EDSS: 0-4.5) and 13 matched subjects without MS were evaluated on the BESTest, asked about fall history, and assessed by force plates and motion capture as they performed laboratory tasks of step initiation, forward leaning to the limits of stability, and postural responses to rotations of the support surface. Compared to subjects without MS, subjects with MS exhibited lower total BESTest scores (mean (95%) score for subjects with MS=91 (83-99); subjects without MS=105 (104-107)) as well as section scores pertaining to mechanical constraints, limits of stability, anticipatory postural adjustments, and gait. BESTest scores significantly correlated with objective laboratory measures of step velocity during step initiation (Pearson r(2)=0.48, P<0.01) as well as center-of-pressure displacements during both the leaning (Pearson r(2)=0.55, P<0.005) and postural-response tasks (Pearson r(2)=0.76, P<0.0001). BESTest total scores were 92% accurate to identify fallers and non-fallers, and BESTest scores significantly correlated with EDSS scores (Spearman's rho=0.85, P<0.0005). Thus, the BESTest provides a valid clinical assessment of balance impairments in people with MS.

  12. Projection-free approximate balanced truncation of large unstable systems

    CERN Document Server

    Flinois, Thibault L B; Schmid, Peter J

    2015-01-01

    In this article, we show that the projection-free, snapshot-based, balanced truncation method can be applied directly to unstable systems. We prove that even for unstable systems, the unmodified balanced proper orthogonal decomposition algorithm theoretically yields a converged transformation that balances the Gramians (including the unstable subspace). We then apply the method to a spatially developing unstable system and show that it results in reduced-order models of similar quality to the ones obtained with existing methods. Due to the unbounded growth of unstable modes, a practical restriction on the final impulse response simulation time appears, which can be adjusted depending on the desired order of the reduced-order model. Recommendations are given to further reduce the cost of the method if the system is large and to improve the performance of the method if it does not yield acceptable results in its unmodified form. Finally, the method is applied to the linearized flow around a cylinder at Re = 100...

  13. Web-based home rehabilitation gaming system for balance training

    Directory of Open Access Journals (Sweden)

    Oleh Kachmar

    2014-06-01

    Full Text Available Currently, most systems for virtual rehabilitation and motor training require quite complex and expensive hardware and can be used only in clinical settings. Now, a low-cost rehabilitation game training system has been developed for patients with movement disorders; it is suitable for home use under the distant supervision of a therapist. It consists of a patient-side application installed on a home computer and the virtual rehabilitation Game Server in the Internet. System can work with different input gaming devices connected through USB or Bluetooth, such as a Nintendo Wii balance board, a Nintendo Wii remote, a MS Kinect sensor, and custom made rehabilitation gaming devices based on a joystick. The same games can be used with all training devices. Assessment of the Home Rehabilitation Gaming System for balance training was performed on six patients with Cerebral Palsy, who went through daily training sessions for two weeks. Preliminary results showed balance improvement in patients with Cerebral Palsy after they had completed home training courses. Further studies are needed to establish medical requirements and evidence length.

  14. CSR BALANCED SCORECARD SYSTEMS AND BUSINESS PERFORMANCES: SMEs CASE STUDY

    Directory of Open Access Journals (Sweden)

    Edward Sek Khin Wong

    2016-01-01

    Full Text Available This paper aims to examine the performance measurement using the CSR Balanced Scorecard system in SMEs firms in Malaysia. It investigates the relationships of the four perspectives of CSR Balanced Scorecard system toward performance measurement. The purpose of this paper is to in- vestigate whether or not the improvement of the non-financial CSR measures will lead to the im- provement of performance measures. To test these relationships, data were collected using the four perspectives approach introduced by Utting (2007. The finding indicates that the organizational business performance can be greatly increased by putting greater emphasis to CSR measures. The results also reveal that the increases of firms customer’s satisfaction is caused by the increase imple- mentation of CSR measurement. At the end of the article, the implications of this study for SME industries and some suggestions are discussed for future studies.

  15. Human Body Exergy Balance: Numerical Analysis of an Indoor Thermal Environment of a Passive Wooden Room in Summer

    Directory of Open Access Journals (Sweden)

    Koichi Isawa

    2015-09-01

    Full Text Available To obtain a basic understanding of the resultant changes in the human body exergy balance (input, consumption, storage, and output accompanying outdoor air temperature fluctuations, a “human body system and a built environmental system” coupled with numerical analysis was conducted. The built environmental system assumed a wooden room equipped with passive cooling strategies, such as thermal insulation and solar shading devices. It was found that in the daytime, the cool radiation exergy emitted by surrounding surfaces, such as walls increased the rate of human body exergy consumption, whereas the warm radiant exergy emitted by the surrounding surfaces at night decreased the rate of human body exergy consumption. The results suggested that the rates and proportions of the different components in the exergy balance equation (exergy input, consumption, storage, and output vary according to the outdoor temperature and humidity conditions.

  16. Offshore Wind Balance-of-System Cost Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Maness, Michael; Stehly, Tyler; Maples, Ben; Mone, Christopher

    2015-09-29

    Offshore wind balance-of-system (BOS) costs contribute up to 70% of installed capital costs. Thus, it is imperative to understand the impact of these costs on project economics as well as potential cost trends for new offshore wind technology developments. As a result, the National Renewable Energy Laboratory (NREL) developed and recently updated a BOS techno-economic model using project cost estimates created from wind energy industry sources.

  17. Spatio-temporal separation of roll and pitch balance-correcting commands in humans.

    NARCIS (Netherlands)

    Gruneberg, C.; Duysens, J.E.J.; Honegger, F.; Allum, J.H.J.

    2005-01-01

    This study was designed to provide evidence for the hypothesis that human balance corrections in response to pitch perturbations are controlled by muscle action mainly about the ankle and knee joints, whereas balance corrections for roll perturbations are controlled predominantly by motion about the

  18. Pedometer and Human Energy Balance Applications for Science Instruction

    Science.gov (United States)

    Rye, James A.; Smolski, Stefan

    2007-01-01

    Teachers can use pedometers to facilitate inquiry learning and show students the need for mathematics in scientific investigation. The authors conducted activities with secondary students that investigated intake and expenditure components of the energy balance algorithm, which led to inquiries about pedometers and related data. By investigating…

  19. Theoretical analysis of balanced truncation for linear switched systems

    DEFF Research Database (Denmark)

    Petreczky, Mihaly; Wisniewski, Rafal; Leth, John-Josef

    2012-01-01

    In this paper we present theoretical analysis of model reduction of linear switched systems based on balanced truncation, presented in [1,2]. More precisely, (1) we provide a bound on the estimation error using L2 gain, (2) we provide a system theoretic interpretation of grammians...... for showing this independence is realization theory of linear switched systems. [1] H. R. Shaker and R. Wisniewski, "Generalized gramian framework for model/controller order reduction of switched systems", International Journal of Systems Science, Vol. 42, Issue 8, 2011, 1277-1291. [2] H. R. Shaker and R....... Wisniewski, "Switched Systems Reduction Framework Based on Convex Combination of Generalized Gramians", Journal of Control Science and Engineering, 2009....

  20. Energy Balance Sheet of a Semi Operational Thermic System

    Directory of Open Access Journals (Sweden)

    Honus Stanislav

    2014-09-01

    Full Text Available The article is focused onthe energetical balance of a technical system for the conversion of crushed tyres by pyrolysis. Process temperatures were set in the range from 500 to 650°C. Mass input of the material was 30 kg per hour. The aim of the article is to answer the following questions as regards the individual products: Under which process conditions can the highest quality of the individual products related to energy be reached? How does the thermal efficiency of the system change in reaction to various conditions of the process?

  1. Modeling and analysis of linear hyperbolic systems of balance laws

    CERN Document Server

    Bartecki, Krzysztof

    2016-01-01

    This monograph focuses on the mathematical modeling of distributed parameter systems in which mass/energy transport or wave propagation phenomena occur and which are described by partial differential equations of hyperbolic type. The case of linear (or linearized) 2 x 2 hyperbolic systems of balance laws is considered, i.e., systems described by two coupled linear partial differential equations with two variables representing physical quantities, depending on both time and one-dimensional spatial variable. Based on practical examples of a double-pipe heat exchanger and a transportation pipeline, two typical configurations of boundary input signals are analyzed: collocated, wherein both signals affect the system at the same spatial point, and anti-collocated, in which the input signals are applied to the two different end points of the system. The results of this book emerge from the practical experience of the author gained during his studies conducted in the experimental installation of a heat exchange cente...

  2. Balance impairment and systemic inflammation in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Tudorache E

    2015-09-01

    Full Text Available Emanuela Tudorache,1 Cristian Oancea,1 Claudiu Avram,2 Ovidiu Fira-Mladinescu,1 Lucian Petrescu,3 Bogdan Timar4 1Department of Pulmonology, University of Medicine and Pharmacy “Victor Babes”, 2Physical Education and Sport Faculty, West University of Timisoara, 3Department of Cardiology, University of Medicine and Pharmacy “Victor Babes”, 4Department of Biostatistics and Medical Informatics, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania Background/purpose: Chronic obstructive pulmonary disease (COPD, especially in severe forms, is commonly associated with systemic inflammation and balance impairment. The aim of our study was to evaluate the impact on equilibrium of stable and exacerbation (acute exacerbation of COPD [AECOPD] phases of COPD and to investigate if there is a connection between lower extremity muscle weakness and systemic inflammation.Methods: We enrolled 41 patients with COPD (22 stable and 19 in AECOPD and 20 healthy subjects (control group, having no significant differences regarding the anthropometric data. We analyzed the differences in balance tests scores: Falls Efficacy Scale-International (FES-I questionnaire, Berg Balance Scale (BBS, Timed Up and Go (TUG test, Single Leg Stance (SLS, 6-minute walking distance (6MWD, isometric knee extension (IKE between these groups, and also the correlation between these scores and inflammatory biomarkers.Results: The presence and severity of COPD was associated with significantly decreased score in IKE (P<0.001, 6MWD (P<0.001, SLS (P<0.001, and BBS (P<0.001, at the same time noting a significant increase in median TUG score across the studied groups (P<0.001. The AECOPD group vs stable group presented a significant increase in high-sensitive C-reactive protein (hs-CRP levels (10.60 vs 4.01; P=0.003 and decrease in PaO2 (70.1 vs 59.1; P<0.001. We observed that both IKE scores were significantly and positive correlated with all the respiratory volumes

  3. Testing Postural Stability: Are the Star Excursion Balance Test and Biodex Balance System Limits of Stability Tests Consistent?

    Science.gov (United States)

    Glave, A Page; Didier, Jennifer J; Weatherwax, Jacqueline; Browning, Sarah J; Fiaud, Vanessa

    2016-01-01

    There are a variety of options to test postural stability; however many physical tests lack validity information. Two tests of postural stability - the Star Excursion Balance Test (SEBT) and Biodex Balance System Limits of Stability Test (LOS) - were examined to determine if similar components of balance were measured. Healthy adults (n=31) completed the LOS (levels 6 and 12) and SEBT (both legs). SEBT directions were offset by 180° to approximate LOS direction. Correlations and partial correlations controlling for height were analyzed. Correlations were significant for SEBT 45° and LOS back-left (6: r=-0.41; 12: r=-0.42; pbalance. Research is needed to determine and define what specific components of balance are being assessed. Care must be taken when choosing balance tests to best match the test to the purpose of testing (fall risk, athletic performance, etc.).

  4. Directional sensitivity of "first trial" reactions in human balance control.

    Science.gov (United States)

    Oude Nijhuis, Lars B; Allum, John H J; Borm, George F; Honegger, Flurin; Overeem, Sebastiaan; Bloem, Bastiaan R

    2009-06-01

    Support-surface movements are commonly used to examine balance control. Subjects typically receive a series of identical or randomly interspersed multidirectional balance perturbations and the atypical "first trial reaction" (evoked by the first perturbation) is often excluded from further analysis. However, this procedure may obscure vital information about neurophysiological mechanisms associated with the first perturbation and, by analogy, fully unexpected falls. We studied first trial reactions, aiming to clarify their directional impact on postural control and to characterize the underlying neurophysiological substrate. We instructed 36 subjects to maintain balance following support-surface rotations in six different directions. Perturbations in each direction were delivered in blocks, consisting of 10 serial stimuli. Full body kinematics, surface reactive forces, and electromyographic (EMG) responses were recorded. Regardless of direction, for the very first rotation, displacement of the center of mass was 15% larger compared with the ensuing nine identical rotations (P postural instability, mainly due to increased response amplitudes. Although rapid habituation occurs following presentation of identical stimuli, subjects immediately become unstable again when the perturbation direction suddenly changes. Excessive responses due to a failure to combine proprioceptive and vestibular cues effectively may explain this instability seen with first trials, particularly when falling backward.

  5. Developing a System for Efficient Analysis of Lumbosacral Sagittal Balance

    Directory of Open Access Journals (Sweden)

    D. M. Zhuk

    2015-01-01

    Full Text Available Lumbosacral sagittal balance is the neutral vertical alignment in the sagittal plane to provide decreasing stress loading on muscular-ligamentous structures. The achieving sagittal balance is a basis to provide successful surgical treatment and minimize further complications. As of today, there is no standard quantitative evaluation method of sagittal lumbo-sacral balance, which allows conducting its effective analysis and planning surgical treatment taking into consideration the preservation of normal biomechanics of lumbosacral spine. The goal of the study is to develop a diagnostic system for individual correction of lumbo-sacral sagittal balance by the author’s method with automatic counting and optimized matching of data values based on a specified number of terms using medical visualization data. This study has been conducted with RMAPE’s Department of Traumatology and Orthopedic Surgery. To solve the problem, a random searching algorithm has been exploited. The stop condition of the algorithm was to achieve the objective function value in adjusted interval, initial points of which are the calculated (angular values. The interaction of the angular values, used in the proposed method has been investigated, and their proportional change has been proved. Moreover, the mathematical dependence among geometrical and anatomical parameters of lumbosacral spine has been determined. Based on conducted study, a number of algorithms enabling the automation of the individual determination of optimal lumbosacral balance’s parameters at preoperative planning stage for patients with vertebral column diseases have been created. This allows us to raise physician’s efficiency, minimize mid- and long-term risk of postoperative complications, and avoid reoperations, and prognosticate long-term complications already performed surgery.

  6. Balancing Human-machine Interface (HMI) Design in Complex Supervisory Tasks

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Junsu [Khalifa Univ. of Science, Abu Dhabi (United Arab Emirates); Kim, Arryum; Jang, Inseok; Seong, Poonghyun [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2013-05-15

    Human performance aspects such as plant performance, personnel task performance, situation awareness, cognitive workload, teamwork, and anthropomorphic/physiological factor are evaluated with the HUPESS. Even though the HUPESS provides evaluation results in each of the performance aspects for the integrated system validation (ISV), additional researches have been needed to develop methods on how to find out design deficiency leading to poor performance and give a solution for design improvement in HMI. The authors have developed a method of HMI design improvement for the monitoring and detection tasks which was named as 'DEMIS (Difficulty Evaluation Method in Information Searching)'. The DEMIS is a HMI evaluation method which bridge poor performance and design improvement. Lessons learned from the existing studies lead to a question about how to optimize the whole HMI design. Human factors principles provide the foundation for guidelines of various codes and standards in designing HMIs. Also in NPPs, a lot of guidelines directly from various codes and standard and derived from various research and development projects are available for designing MCR HMIs. In this study, a balancing principle and relevant two measures for HMI design optimization are proposed to be used in the HMI design of complex supervisory tasks in NPPs. The balancing principle is that a HMI element (e. g., an indicator or a push button) should be designed according to its importance.

  7. Human Emotion Recognition System

    Directory of Open Access Journals (Sweden)

    Dilbag Singh

    2012-08-01

    Full Text Available This paper discusses the application of feature extraction of facial expressions with combination of neural network for the recognition of different facial emotions (happy, sad, angry, fear, surprised, neutral etc... Humans are capable of producing thousands of facial actions during communication that vary in complexity, intensity, and meaning. This paper analyses the limitations with existing system Emotion recognition using brain activity. In this paper by using an existing simulator I have achieved 97 percent accurate results and it is easy and simplest way than Emotion recognition using brain activity system. Purposed system depends upon human face as we know face also reflects the human brain activities or emotions. In this paper neural network has been used for better results. In the end of paper comparisons of existing Human Emotion Recognition System has been made with new one.

  8. Creating a balanced scorecard for a hospital system.

    Science.gov (United States)

    Pink, G H; McKillop, I; Schraa, E G; Preyra, C; Montgomery, C; Baker, G R

    2001-01-01

    In 1999, hospitals in Ontario, Canada, collaborated with a university-based research team to develop a report on the relative performance of individual hospitals in Canada's most populated province. The researchers used the balanced-scorecard framework advocated by Kaplan and Norton. Indicators of performance were developed in four areas: clinical utilization and outcomes, patient satisfaction, system integration and change, and financial performance and condition. The process of selecting, calculating, and validating meaningful indicators of financial performance and condition is outlined. Lessons learned along the way are provided. These lessons may prove valuable to other finance researchers and practitioners who are engaged in performance measurement endeavors.

  9. Arctic melt ponds and energy balance in the climate system

    Science.gov (United States)

    Sudakov, Ivan

    2017-02-01

    Elements of Earth's cryosphere, such as the summer Arctic sea ice pack, are melting at precipitous rates that have far outpaced the projections of large scale climate models. Understanding key processes, such as the evolution of melt ponds that form atop Arctic sea ice and control its optical properties, is crucial to improving climate projections. These types of critical phenomena in the cryosphere are of increasing interest as the climate system warms, and are crucial for predicting its stability. In this paper, we consider how geometrical properties of melt ponds can influence ice-albedo feedback and how it can influence the equilibria in the energy balance of the planet.

  10. Human immune system variation.

    Science.gov (United States)

    Brodin, Petter; Davis, Mark M

    2017-01-01

    The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's immune system is now becoming clearer. Human immune systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human immune system is key for defining metrics of immunological health and understanding the risk of immune-mediated and infectious diseases.

  11. Rotated balance in humans due to repetitive rotational movement.

    Science.gov (United States)

    Zakynthinaki, M S; Milla, J Madera; De Durana, A López Diaz; Martínez, C A Cordente; Romo, G Rodríguez; Quintana, M Sillero; Molinuevo, J Sampedro

    2010-03-01

    We show how asymmetries in the movement patterns during the process of regaining balance after perturbation from quiet stance can be modeled by a set of coupled vector fields for the derivative with respect to time of the angles between the resultant ground reaction forces and the vertical in the anteroposterior and mediolateral directions. In our model, which is an adaption of the model of Stirling and Zakynthinaki (2004), the critical curve, defining the set of maximum angles one can lean to and still correct to regain balance, can be rotated and skewed so as to model the effects of a repetitive training of a rotational movement pattern. For the purposes of our study a rotation and a skew matrix is applied to the critical curve of the model. We present here a linear stability analysis of the modified model, as well as a fit of the model to experimental data of two characteristic "asymmetric" elite athletes and to a "symmetric" elite athlete for comparison. The new adapted model has many uses not just in sport but also in rehabilitation, as many work place injuries are caused by excessive repetition of unaligned and rotational movement patterns.

  12. Magnetic suspension and balance system advanced study, phase 2

    Science.gov (United States)

    Boom, R. W.; Abdelsalam, M. K.; Eyssa, Y. M.; Mcintosh, G. E.

    1990-01-01

    The design improvements for the system encompass 14 or 18 external superconductive coils mounted on a 8 x 8 foot wind tunnel, a superconductive model core magnet on a holmium mandrel to fit an F-16 model, model wings of permanent magnet material Nd2Fe14B, and fiber glass epoxy structure. The Magnetic Suspension and Balance System (MSBS) advanced design is confirmed by the successful construction and test of a full size superconductive model core solenoid with holmium mandrel. The solenoid is 75 cm long and 12.6 cm in diameter and produces 6.1 tesla for a hold time of 47 minutes. An integrated coil system design of a new compact configuration without specific coils for roll or pitch shows promise of simplicity; magnet reductions of 30 percent compared to the most recent 1985 design are possible.

  13. Balance impairment and systemic inflammation in chronic obstructive pulmonary disease

    Science.gov (United States)

    Tudorache, Emanuela; Oancea, Cristian; Avram, Claudiu; Fira-Mladinescu, Ovidiu; Petrescu, Lucian; Timar, Bogdan

    2015-01-01

    Background/purpose Chronic obstructive pulmonary disease (COPD), especially in severe forms, is commonly associated with systemic inflammation and balance impairment. The aim of our study was to evaluate the impact on equilibrium of stable and exacerbation (acute exacerbation of COPD [AECOPD]) phases of COPD and to investigate if there is a connection between lower extremity muscle weakness and systemic inflammation. Methods We enrolled 41 patients with COPD (22 stable and 19 in AECOPD) and 20 healthy subjects (control group), having no significant differences regarding the anthropometric data. We analyzed the differences in balance tests scores: Falls Efficacy Scale-International (FES-I) questionnaire, Berg Balance Scale (BBS), Timed Up and Go (TUG) test, Single Leg Stance (SLS), 6-minute walking distance (6MWD), isometric knee extension (IKE) between these groups, and also the correlation between these scores and inflammatory biomarkers. Results The presence and severity of COPD was associated with significantly decreased score in IKE (P<0.001), 6MWD (P<0.001), SLS (P<0.001), and BBS (P<0.001), at the same time noting a significant increase in median TUG score across the studied groups (P<0.001). The AECOPD group vs stable group presented a significant increase in high-sensitive C-reactive protein (hs-CRP) levels (10.60 vs 4.01; P=0.003) and decrease in PaO2 (70.1 vs 59.1; P<0.001). We observed that both IKE scores were significantly and positive correlated with all the respiratory volumes. In both COPD groups, we observed that fibrinogen reversely and significantly correlated with the 6MWD, and FES-I questionnaire is correlated positively with TUG test. Hs-CRP correlated reversely with the walking test and SLS test, while correlating positively with TUG test and FES-I questionnaire. Conclusion According to this study, COPD in advanced and acute stages is associated with an increased history of falls, systemic inflammation, balance impairment, and lower extremity

  14. International human rights and cultural diversity: a balancing act

    NARCIS (Netherlands)

    Donders, Y.

    2013-01-01

    It is broadly agreed that international human rights law and cultural diversity have a mutually interdependent and beneficial relationship. Many human rights, such as the rights to freedom of expression, freedom of religion, freedom of assembly, as well as the rights to take part in cultural life an

  15. Group & Intergroup Relations in Living Human Systems.

    Science.gov (United States)

    1980-06-01

    investigations summarized in Table 2-1 include analyses of a broad range of system properties (cf. Adorno et al, 1950, MacKinnon, 1965; Beavers, 1977, Goffman...also characteristic of the authoritarian personality ( Adorno , et al., 1950). The balance of feeling within an underbounded system is typically less...groups being studied. 2 - 45 REFERENCES Adam R.N. and Preiss, J.J. (eds.) Human Organization Research. Homewood, Illinois: Dorsey, 1960. Adorno , T.W

  16. CORRELATION BETWEEN HUMAN NEEDS SYSTEM - PERSONALITY - HUMAN MOTIVATION

    OpenAIRE

    Mirela MINICA

    2015-01-01

    The article highlights the main attributes of an economic approach of needs and preferences, with detailed focus on the correlation between meta-needs and personality, by correlating the principle of hierarchy established by Maslow with the balance theory. Adopting an integrated system of human capital motivation, which takes into account the complex aspects involved in the knowledge society, represents a managerial requirement for any organisation.

  17. CORRELATION BETWEEN HUMAN NEEDS SYSTEM - PERSONALITY - HUMAN MOTIVATION

    Directory of Open Access Journals (Sweden)

    Mirela MINICA

    2015-07-01

    Full Text Available The article highlights the main attributes of an economic approach of needs and preferences, with detailed focus on the correlation between meta-needs and personality, by correlating the principle of hierarchy established by Maslow with the balance theory. Adopting an integrated system of human capital motivation, which takes into account the complex aspects involved in the knowledge society, represents a managerial requirement for any organisation.

  18. Human Systems Design Criteria

    DEFF Research Database (Denmark)

    Rasmussen, Jens

    1982-01-01

    the necessary functional qualities but also the needed human qualities. The author's main argument is, that the design process should be a dialectical synthesis of the two points of view: Man as a System Component, and System as Man's Environment. Based on a man's presentation of the state of the art a set...... of design criteria is suggested and their relevance discussed. The point is to focus on the operator rather than on the computer. The crucial question is not to program the computer to work on its own conditions, but to “program” the operator to function on human conditions.......This paper deals with the problem of designing more humanised computer systems. This problem can be formally described as the need for defining human design criteria, which — if used in the design process - will secure that the systems designed get the relevant qualities. That is not only...

  19. ROCKing cytokine secretion balance in human T cells.

    Science.gov (United States)

    Zanin-Zhorov, Alexandra; Waksal, Samuel D

    2015-04-01

    Balanced regulation of cytokine secretion in T cells is critical for maintenance of immune homeostasis and prevention of autoimmunity. The Rho-associated kinase (ROCK) 2 signaling pathway was previously shown to be involved in controlling of cellular movement and shape. However, recent work from our group and others has demonstrated a new and important role of ROCK2 in regulating cytokine secretion in T cells. We found that ROCK2 promotes pro-inflammatory cytokines such as IL-17 and IL-21, whereas IL-2 and IL-10 secretion are negatively regulated by ROCK2 under Th17-skewing activation. Also, in disease, but not in steady state conditions, ROCK2 contributes to regulation of IFN-γ secretion in T cells from rheumatoid arthritis patients. Thus, ROCK2 signaling is a key pathway in modulation of T-cell mediated immune responses underscoring the therapeutic potential of targeted inhibition of ROCK2 in autoimmunity.

  20. Balance perturbation system to improve balance compensatory responses during walking in old persons

    OpenAIRE

    2010-01-01

    Abstract Ageing commonly disrupts the balance control and compensatory postural responses that contribute to maintaining balance and preventing falls during perturbation of posture. This can lead to increased risk of falling in old adults (65 years old and over). Therefore, improving compensatory postural responses during walking is one of the goals in fall prevention programs. Training is often used to achieve this goal. Most fall prevention programs are usually directed towards improving vo...

  1. Dynamic Balance of Excitation and Inhibition in Human and Monkey Neocortex

    Science.gov (United States)

    Dehghani, Nima; Peyrache, Adrien; Telenczuk, Bartosz; Le van Quyen, Michel; Halgren, Eric; Cash, Sydney S.; Hatsopoulos, Nicholas G.; Destexhe, Alain

    2016-03-01

    Balance of excitation and inhibition is a fundamental feature of in vivo network activity and is important for its computations. However, its presence in the neocortex of higher mammals is not well established. We investigated the dynamics of excitation and inhibition using dense multielectrode recordings in humans and monkeys. We found that in all states of the wake-sleep cycle, excitatory and inhibitory ensembles are well balanced, and co-fluctuate with slight instantaneous deviations from perfect balance, mostly in slow-wave sleep. Remarkably, these correlated fluctuations are seen for many different temporal scales. The similarity of these computational features with a network model of self-generated balanced states suggests that such balanced activity is essentially generated by recurrent activity in the local network and is not due to external inputs. Finally, we find that this balance breaks down during seizures, where the temporal correlation of excitatory and inhibitory populations is disrupted. These results show that balanced activity is a feature of normal brain activity, and break down of the balance could be an important factor to define pathological states.

  2. Increasing cropping system diversity balances productivity, profitability and environmental health.

    Science.gov (United States)

    Davis, Adam S; Hill, Jason D; Chase, Craig A; Johanns, Ann M; Liebman, Matt

    2012-01-01

    Balancing productivity, profitability, and environmental health is a key challenge for agricultural sustainability. Most crop production systems in the United States are characterized by low species and management diversity, high use of fossil energy and agrichemicals, and large negative impacts on the environment. We hypothesized that cropping system diversification would promote ecosystem services that would supplement, and eventually displace, synthetic external inputs used to maintain crop productivity. To test this, we conducted a field study from 2003-2011 in Iowa that included three contrasting systems varying in length of crop sequence and inputs. We compared a conventionally managed 2-yr rotation (maize-soybean) that received fertilizers and herbicides at rates comparable to those used on nearby farms with two more diverse cropping systems: a 3-yr rotation (maize-soybean-small grain + red clover) and a 4-yr rotation (maize-soybean-small grain + alfalfa-alfalfa) managed with lower synthetic N fertilizer and herbicide inputs and periodic applications of cattle manure. Grain yields, mass of harvested products, and profit in the more diverse systems were similar to, or greater than, those in the conventional system, despite reductions of agrichemical inputs. Weeds were suppressed effectively in all systems, but freshwater toxicity of the more diverse systems was two orders of magnitude lower than in the conventional system. Results of our study indicate that more diverse cropping systems can use small amounts of synthetic agrichemical inputs as powerful tools with which to tune, rather than drive, agroecosystem performance, while meeting or exceeding the performance of less diverse systems.

  3. Increasing cropping system diversity balances productivity, profitability and environmental health.

    Directory of Open Access Journals (Sweden)

    Adam S Davis

    Full Text Available Balancing productivity, profitability, and environmental health is a key challenge for agricultural sustainability. Most crop production systems in the United States are characterized by low species and management diversity, high use of fossil energy and agrichemicals, and large negative impacts on the environment. We hypothesized that cropping system diversification would promote ecosystem services that would supplement, and eventually displace, synthetic external inputs used to maintain crop productivity. To test this, we conducted a field study from 2003-2011 in Iowa that included three contrasting systems varying in length of crop sequence and inputs. We compared a conventionally managed 2-yr rotation (maize-soybean that received fertilizers and herbicides at rates comparable to those used on nearby farms with two more diverse cropping systems: a 3-yr rotation (maize-soybean-small grain + red clover and a 4-yr rotation (maize-soybean-small grain + alfalfa-alfalfa managed with lower synthetic N fertilizer and herbicide inputs and periodic applications of cattle manure. Grain yields, mass of harvested products, and profit in the more diverse systems were similar to, or greater than, those in the conventional system, despite reductions of agrichemical inputs. Weeds were suppressed effectively in all systems, but freshwater toxicity of the more diverse systems was two orders of magnitude lower than in the conventional system. Results of our study indicate that more diverse cropping systems can use small amounts of synthetic agrichemical inputs as powerful tools with which to tune, rather than drive, agroecosystem performance, while meeting or exceeding the performance of less diverse systems.

  4. Human rights and public health : towards a balanced relationship

    NARCIS (Netherlands)

    Toebes, Brigit

    This contribution attempts to scope the multiple and complex relationships between measures to protect health and the protection of human rights. The article begins with a discussion of the meaning and current understandings of the notion of ‘public health’, after which it explores how ‘public

  5. Energy Balance for Random Vibrations of Piecewise-Conservative Systems

    Science.gov (United States)

    IOURTCHENKO, D. V.; DIMENTBERG, M. F.

    2001-12-01

    Vibrations of systems with instantaneous or stepwise energy losses, e.g., due to impacts with imperfect rebounds, dry friction forces(s) (in which case the losses may be treated as instantaneous ones by appropriate introduction of the response energy) and/or active feedback “bang-bang” control of the systems' response are considered. Response of such (non-linear) systems to a white-noise random excitation is considered for the case where there are no other response energy losses. Thus, a simple linear energy growth with time between “jumps” is observed. Explicit expressions for the expected response energy are derived by direct application of the stochastic differential equations calculus, which contains the expected time interval between two consecutive jumps. The latter may be predicted as a solution to the relevant first-passage problem. Perturbational analysis of the relevant PDE for this problem for a certain vibroimpact system demonstrated the possibility for using the solution to the corresponding free vibration problem as a zero order approximation. The method is applied to an s.d.o.f. system with a feedback inertia control, designed according to a certain previously introduced “generalized reversed swings law”. Extensive Monte-Carlo simulation results are presented for this system as well as for several previously analyzed ones: system with impacts; system with dry friction; system with stiffness control; pendulum with controlled length. The results are compared with those due to the asymptotic stochastic averaging approach. Both methods are shown to provide adequate accuracy far beyond the expected applicability range of the asymptotic approach (which requires both excitation intensity and losses to be small), with direct energy balance being generally superior.

  6. Altered balance in the autonomic nervous system in schizophrenic patients

    DEFF Research Database (Denmark)

    Nielsen, B M; Mehlsen, J; Behnke, K

    1988-01-01

    healthy subjects (32 +/- 7 years) served as controls. Immediate heart-rate responses to a single deep inspiration was used as a measure of parasympathetic function. Heart-rate response to standing was used as a measure of sympathetic function. Supine blood pressure, heart-rate and orthostatic changes...... in blood pressure did not differ between groups. Heart-rate response to standing was greater in both medicated and non-medicated schizophrenics compared to normal subjects (P less than 0.01). Heart-rate response to standing was greater in non-medicated compared to medicated schizophrenics (P less than 0.......05). Heart-rate response to inspiration was greater in non-medicated schizophrenics compared to normal subjects (P less than 0.05), whereas no difference was found between medicated and non-medicated schizophrenics. The results show that the balance in the autonomic nervous system is altered in schizophrenic...

  7. E-I balance and human diseases - from molecules to networking

    Directory of Open Access Journals (Sweden)

    Sabrina A Eichler

    2008-05-01

    Full Text Available Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.

  8. Judicial Control over Althingi: Altered Balance of Powers in the Constitutional System

    Directory of Open Access Journals (Sweden)

    Björg Thorarensen

    2016-06-01

    Full Text Available The article focuses on how the control of the judiciary over the legislature has increased in the last decades and the reasons for altered balance of powers in the Icelandic constitutional system are explored. Earlier theories of parliamentary precedence over other branches of state power are in transition. There is a growing trend towards the balancing of powers, in which the courts monitor that legislation complies with the constitution. A comparison is made with the developments in the constitutional systems of Denmark and Norway which points at the same direction. The European Convention on Human Rights and constitutional amendments in 1995 have affected the interpretation methods of the Icelandic courts and strengthened their supervisory role. Ideas underlying constitutional democracy, rule of law and effective remedies for individuals are prevailing over the idea of preferred position of the legislative power vis-à-vis the judiciary. The courts see it as a constitutional duty to adjudicate whether a legislative act conforms with constitutional human rights. The Supreme Court of Iceland has referred to the wide discretion of the legislature in the field of fiscal powers, such as regarding taxation and the social security system. However, even where legislation aims at the implementation of important political policies, the discretion of Althingi is subject to certain limits. The effective judicial control requires that Althingi must assess carefully whether legislation which limits constitutionally protected human rights conforms with the principles of equality and proportionality.

  9. Photovoltaic balance-of-system designs and costs at PVUSA

    Energy Technology Data Exchange (ETDEWEB)

    Reyes, A.B.; Jennings, C.

    1995-05-01

    This report is one in a series of 1994-1995 PVUSA reports that document PVUSA lessons learned at demonstration sites in California and Texas. During the last 7 years (1988 to 1994), 16 PV systems ranging from 20 kW to 500 kW have been installed. Six 20-kW emerging module technology (EMT) arrays and three turnkey (i.e., vendor designed and integrated) utility-scale systems were procured and installed at PVUSA`s main test site in Davis, California. PVUSA host utilities have installed a total of seven EMT arrays and utility-scale systems in their service areas. Additional systems at Davis and host utility sites are planned. One of PVUSA`s key objectives is to evaluate the performance, reliability, and cost of PV balance-of-system (BOS). In the procurement stage PVUSA encouraged innovative design to improve upon present practice by reducing maintenance, improving reliability, or lowering manufacturing or construction costs. The project team worked closely with suppliers during the design stage not only to ensure designs met functional and safety specifications, but to provide suggestions for improvement. This report, intended for the photovoltaic (PV) industry and for utility project managers and engineers considering PV plant construction and ownership, documents PVUSA utility-scale system design and cost lessons learned. Complementary PVUSA topical reports document: construction and safety experience; five-year assessment of EMTs; validation of the Kerman 500-kW grid-support PV plant benefits; PVUSA instrumentation and data analysis techniques; procurement, acceptance, and rating practices for PV power plants; experience with power conditioning units and power quality.

  10. The time-delayed inverted pendulum: Implications for human balance control

    Science.gov (United States)

    Milton, John; Cabrera, Juan Luis; Ohira, Toru; Tajima, Shigeru; Tonosaki, Yukinori; Eurich, Christian W.; Campbell, Sue Ann

    2009-06-01

    The inverted pendulum is frequently used as a starting point for discussions of how human balance is maintained during standing and locomotion. Here we examine three experimental paradigms of time-delayed balance control: (1) mechanical inverted time-delayed pendulum, (2) stick balancing at the fingertip, and (3) human postural sway during quiet standing. Measurements of the transfer function (mechanical stick balancing) and the two-point correlation function (Hurst exponent) for the movements of the fingertip (real stick balancing) and the fluctuations in the center of pressure (postural sway) demonstrate that the upright fixed point is unstable in all three paradigms. These observations imply that the balanced state represents a more complex and bounded time-dependent state than a fixed-point attractor. Although mathematical models indicate that a sufficient condition for instability is for the time delay to make a corrective movement, τn, be greater than a critical delay τc that is proportional to the length of the pendulum, this condition is satisfied only in the case of human stick balancing at the fingertip. Thus it is suggested that a common cause of instability in all three paradigms stems from the difficulty of controlling both the angle of the inverted pendulum and the position of the controller simultaneously using time-delayed feedback. Considerations of the problematic nature of control in the presence of delay and random perturbations ("noise") suggest that neural control for the upright position likely resembles an adaptive-type controller in which the displacement angle is allowed to drift for small displacements with active corrections made only when θ exceeds a threshold. This mechanism draws attention to an overlooked type of passive control that arises from the interplay between retarded variables and noise.

  11. Regulatory aspects of human radiolabeled mass balance studies in oncology : concise review

    NARCIS (Netherlands)

    Nijenhuis, C. M.; Schellens, J. H M|info:eu-repo/dai/nl/073926272; Beijnen, J. H.|info:eu-repo/dai/nl/071919570

    2016-01-01

    Human radiolabeled mass balance studies are performed to obtain information about the absorption, distribution, metabolism, and excretion of a drug in development. The main goals are to determine the route of elimination and major metabolic pathways. This review provides an overview of the current

  12. Responses of human hip abductor muscles to lateral balance perturbations during walking

    NARCIS (Netherlands)

    Hof, A. L.; Duysens, J.

    2013-01-01

    Lateral stability during gait is of utmost importance to maintain balance. This was studied on human subjects walking on a treadmill who were given 100-ms perturbations of known magnitude and timing with respect to the gait cycle by means of a computer-controlled pneumatic device. This method has th

  13. Responses of human hip abductor muscles to lateral balance perturbations during walking

    NARCIS (Netherlands)

    Hof, A. L.; Duysens, J.

    2013-01-01

    Lateral stability during gait is of utmost importance to maintain balance. This was studied on human subjects walking on a treadmill who were given 100-ms perturbations of known magnitude and timing with respect to the gait cycle by means of a computer-controlled pneumatic device. This method has th

  14. Regulatory aspects of human radiolabeled mass balance studies in oncology : concise review

    NARCIS (Netherlands)

    Nijenhuis, C. M.; Schellens, J. H M; Beijnen, J. H.

    2016-01-01

    Human radiolabeled mass balance studies are performed to obtain information about the absorption, distribution, metabolism, and excretion of a drug in development. The main goals are to determine the route of elimination and major metabolic pathways. This review provides an overview of the current r

  15. Artificial balance: restoration of the vestibulo-ocular reflex in humans with a prototype vestibular neuroprosthesis.

    Science.gov (United States)

    Perez Fornos, Angelica; Guinand, Nils; van de Berg, Raymond; Stokroos, Robert; Micera, Silvestro; Kingma, Herman; Pelizzone, Marco; Guyot, Jean-Philippe

    2014-01-01

    The vestibular system plays a crucial role in the multisensory control of balance. When vestibular function is lost, essential tasks such as postural control, gaze stabilization, and spatial orientation are limited and the quality of life of patients is significantly impaired. Currently, there is no effective treatment for bilateral vestibular deficits. Research efforts both in animals and humans during the last decade set a solid background to the concept of using electrical stimulation to restore vestibular function. Still, the potential clinical benefit of a vestibular neuroprosthesis has to be demonstrated to pave the way for a translation into clinical trials. An important parameter for the assessment of vestibular function is the vestibulo-ocular reflex (VOR), the primary mechanism responsible for maintaining the perception of a stable visual environment while moving. Here we show that the VOR can be artificially restored in humans using motion-controlled, amplitude modulated electrical stimulation of the ampullary branches of the vestibular nerve. Three patients received a vestibular neuroprosthesis prototype, consisting of a modified cochlear implant providing vestibular electrodes. Significantly higher VOR responses were observed when the prototype was turned ON. Furthermore, VOR responses increased significantly as the intensity of the stimulation increased, reaching on average 79% of those measured in healthy volunteers in the same experimental conditions. These results constitute a fundamental milestone and allow us to envision for the first time clinically useful rehabilitation of patients with bilateral vestibular loss.

  16. Artificial balance: restoration of the vestibulo-ocular reflex in humans with a prototype vestibular neuroprosthesis

    Directory of Open Access Journals (Sweden)

    Angelica ePerez Fornos

    2014-04-01

    Full Text Available The vestibular system plays a crucial role in the multisensory control of balance. When vestibular function is lost, essential tasks such as postural control, gaze stabilization, and spatial orientation are limited and the quality of life of patients is significantly impaired. Currently there is no effective treatment for bilateral vestibular deficits. Research efforts both in animals and humans during the last decade set a solid background to the concept of using electrical stimulation to restore vestibular function. Still, the potential clinical benefit of a vestibular neuroprosthesis has to be demonstrated to pave the way for a translation into clinical trials. An important parameter for the assessment of vestibular function is the Vestibulo-Ocular Reflex (VOR, the primary mechanism responsible for maintaining the perception of a stable visual environment while moving. Here we show that the VOR can be artificially restored in humans using motion-controlled, amplitude modulated electrical stimulation of the ampullary branches of the vestibular nerve. Three patients received a vestibular neuroprosthesis prototype, consisting of a modified cochlear implant providing vestibular electrodes. Significantly higher VOR responses were observed when the prototype was turned ON. Furthermore, VOR responses increased significantly as the intensity of the stimulation increased, reaching on average 79% of those measured in healthy volunteers in the same experimental conditions. These results constitute a fundamental milestone and allow us to envision for the first time clinically useful rehabilitation of patients with bilateral vestibular loss.

  17. Advanced Modular "All in One" Battery System with Intelligent Autonomous Cell Balancing Management

    Science.gov (United States)

    Petitdidier, X.; Pasquier, E.; Defer, M.; Koch, M.; Knorr, W.

    2008-09-01

    A new generation of energy storage systems based on Li-ion technology emerged at the end of the last century.To perform the first tests in safe conditions, Saft designed a simple electronic.Today, all Li-ion batteries for autonomous applications such as drones, launchers, missiles, torpedoes and "human" applications such as cellular, laptop, hybrid vehicle and nearly sub-marines need a Battery Management System.The minimum in terms of functions is the overcharge and over-discharge protections.For a battery made of 2 cells connected in series or more, a balancing system is added to maintain the available energy during all the life of the battery. For stringent/demanding applications, the state of charge and state of health are calculated by one or more computers.It is now time to take benefit of the past 10 years of Saft's experience in the domain to re-evaluate the constraints of Li-ion batteries and provide customers with improved products by optimizing the battery management.Benefits of electronic for satellite applications:• Full control over battery.• Confidence whatever the possible change of conditions in environment.• The battery system can resist long exposure to gradient conditions with mitigated and stabilized impact on performances.• The balancing function allow to use all the energy of all the cells: optimize of installed energy (compact design, mass saving). It started out with the basic fact that electrochemists are not intended to be space rated electronic experts and vice versa, even if Saft has a good heritage in the electronic battery management system. Consequently, considering heritage and expertise in their respective core businesses, Saft and ASP teamed up.It became necessary to provide an "all in one" modular energy storage system with intelligent autonomous cell balancing management.

  18. Market integration of wind power in electricity system balancing

    DEFF Research Database (Denmark)

    Sorknæs, Peter; Andersen, Anders N.; Tang, Jens

    2013-01-01

    In most countries markets for electricity are divided into wholesale markets on which electricity is traded before the operation hour, and real-time balancing markets to handle the deviations from the wholesale trading. So far, wind power has been sold only on the wholesale market and has been...... known to increase the need for balancing. This article analyses whether wind turbines in the future should participate in the balancing markets and thereby play a proactive role. The analysis is based on a real-life test of proactive participation of a wind farm in West Denmark. It is found...

  19. Potential benefits of magnetic suspension and balance systems

    Science.gov (United States)

    Lawing, Pierce L.; Dress, David A.; Kilgore, Robert A.

    1987-01-01

    The potential of Magnetic Suspension and Balance Systems (MSBS) to improve conventional wind tunnel testing techniques is discussed. Topics include: elimination of model geometry distortion and support interference to improve the measurement accuracy of aerodynamic coefficients; removal of testing restrictions due to supports; improved dynamic stability data; and stores separation testing. Substantial increases in wind tunnel productivity are anticipated due to the coalescence of these improvements. Specific improvements in testing methods for missiles, helicopters, fighter aircraft, twin fuselage transports and bombers, state separation, water tunnels, and automobiles are also forecast. In a more speculative vein, new wind tunnel test techniques are envisioned as a result of applying MSBS, including free-flight computer trajectories in the test section, pilot-in-the-loop and designer-in-the-loop testing, shipboard missile launch simulation, and optimization of hybrid hypersonic configurations. Also addressed are potential applications of MSBS to such diverse technologies as medical research and practice, industrial robotics, space weaponry, and ore processing in space.

  20. Solar, Install, Mount, Production, Labor, Equipment Balance of Systems

    Energy Technology Data Exchange (ETDEWEB)

    Gentry, Russell [Georgia Tech Applied Research Corporation, Atlanta, GA (United States); Al-Haddad, Tristan [Georgia Tech Applied Research Corporation, Atlanta, GA (United States); Valdes, Francisco [Georgia Tech Applied Research Corporation, Atlanta, GA (United States); Caravati, Kevin [Georgia Tech Applied Research Corporation, Atlanta, GA (United States); Goodman, Joseph [Georgia Tech Applied Research Corporation, Atlanta, GA (United States)

    2015-08-27

    The GTRI led project team in partnership with the DOE, universities, and numerous industry leaders, have advanced the mission of the DOE EERE, the Solar Energy Technologies Program, and the SunShot Initiative by accelerating the research, development, and demonstration of solar PV technologies that provide Extreme Balance of Systems Cost Reductions (BOS-X). The research produced 132 design concepts, resulting in 19 invention disclosures, five patent applications, four 90% pre-commercial designs, and three licensed technologies. Technology practice rights were obtained by an industry partner, and a new solar commercial start-up company was launched in Atlanta as a result of this project. Innovations in residential, commercial, and utility scale balance of systems technologies were realized through an unprecedented multi-disciplinary university/industry partnership with over 50 students and 24 faculty members that produced 18 technical publications, a PhD thesis, and two commercially deployed operating prototypes. The technical effectiveness and economic feasibility of the multidisciplinary systems based approach executed by the project team was realized through 1) a comprehensive evaluation of industry, regulatory, and public stakeholder requirements; 2) numerous industry/student/faculty engagements in design studios, technical conferences, and at solar PV installation sites; 3) time and motion studies with domain experts that provided technical data and costs for each phase and component of the solar PV installation processes; 4) extensive wind tunnel and systems engineering modeling; and 5) design, construction, and demonstration of the selected technologies in the field at high profile sites in Atlanta. The SIMPLE BOS project has benefitted the public in the following ways: • Workforce development: The launch of a start-up company to commercialize the DOE funded SIMPLE BoS designs has directly created 9 new jobs in the State of Georgia. As of November 2014, the

  1. A Half-Bridge Voltage Balancer with New Controller for Bipolar DC Distribution Systems

    Directory of Open Access Journals (Sweden)

    Byung-Moon Han

    2016-03-01

    Full Text Available This paper proposes a half-bridge voltage balancer with a new controller for bipolar DC distribution systems. The proposed control scheme consists of two cascaded Proportional Integral (PI controls rather than one PI control for balancing the pole voltage. In order to confirm the excellence of voltage balancing performance, a typical bipolar DC distribution system including a half-bridge voltage balancer with proposed controller was analyzed by computer simulations. Experiments with a scaled prototype were also carried out to confirm the simulation results. The half-bridge voltage balancer with proposed controller shows better performance than the half-bridge voltage balancer with one PI control for balancing the pole voltage.

  2. Cerebral water and ion balance remains stable when humans are exposed to acute hypoxic exercise

    DEFF Research Database (Denmark)

    Avnstorp, Magnus B; Rasmussen, Peter; Brassard, Patrice

    2015-01-01

    Avnstorp, Magnus B., Peter Rasmussen, Patrice Brassard, Thomas Seifert, Morten Overgaard, Peter Krustrup, Niels H. Secher, and Nikolai B. Nordsborg. Cerebral water and ion balance remains stable when humans are exposed to acute hypoxic exercise. High Alt Med Biol 16:000-000, 2015.-Background...... metabolism and increased an index of cerebral blood flow, but cerebral net water and ion homeostasis remained stable. Thus, although AMS develops within hours and may be related to exercise-induced disturbance of cerebral ion and water balance, such changes are not detectable when subjects are exposed...

  3. Design of NAND FLASH File System Based on Loss of Balance Algorithm

    Directory of Open Access Journals (Sweden)

    Jinwu Ju

    2011-02-01

    Full Text Available NAND FLASH is a commonly large capacity memory, which used in embedded systems .It often used to store the operating system kernel and file system. NAND FLASH memory has a limited number of block erase feature. Built file system in NAND FLASH, loss of balance method should be adopted. A balanced system of block erase operation, can extend the life of NAND FLASH and improve overall system reliability. The paper analyzes the characteristics of NAND FLASH work .presents a loss of balance algorithm which used in NAND FLASH memory , and given out the implementation of the algorithm design method.

  4. THE OPTIMUM MODEL AND ITS DECISION SUPPORT SYSTEM OF COAL QUALITY BALANCE

    Institute of Scientific and Technical Information of China (English)

    孟祥瑞; 舒航

    1999-01-01

    The meaning and significance of coal quality balance are summarized in this paper. Practical steps concerning constructing the synthetic tech-economic model and its decision support system of coal quality balance using the optimization technology of inverse recurrence of established initializing parameters are also introduced. The principles and methods as being applied in the model system development and procedure construction are discussed accordingly.

  5. Measuring Center of Pressure Signals to Quantify Human Balance Using Multivariate Multiscale Entropy by Designing a Force Platform

    Directory of Open Access Journals (Sweden)

    Cheng-Wei Huang

    2013-08-01

    Full Text Available To assess the improvement of human body balance, a low cost and portable measuring device of center of pressure (COP, known as center of pressure and complexity monitoring system (CPCMS, has been developed for data logging and analysis. In order to prove that the system can estimate the different magnitude of different sways in comparison with the commercial Advanced Mechanical Technology Incorporation (AMTI system, four sway tests have been developed (i.e., eyes open, eyes closed, eyes open with water pad, and eyes closed with water pad to produce different sway displacements. Firstly, static and dynamic tests were conducted to investigate the feasibility of the system. Then, correlation tests of the CPCMS and AMTI systems have been compared with four sway tests. The results are within the acceptable range. Furthermore, multivariate empirical mode decomposition (MEMD and enhanced multivariate multiscale entropy (MMSE analysis methods have been used to analyze COP data reported by the CPCMS and compare it with the AMTI system. The improvements of the CPCMS are 35% to 70% (open eyes test and 60% to 70% (eyes closed test with and without water pad. The AMTI system has shown an improvement of 40% to 80% (open eyes test and 65% to 75% (closed eyes test. The results indicate that the CPCMS system can achieve similar results to the commercial product so it can determine the balance.

  6. Market integration of wind power in electricity system balancing

    DEFF Research Database (Denmark)

    Sorknæs, Peter; Andersen, Anders N.; Tang, Jens

    2013-01-01

    In most countries markets for electricity are divided into wholesale markets on which electricity is traded before the operation hour, and real-time balancing markets to handle the deviations from the wholesale trading. So far, wind power has been sold only on the wholesale market and has been...... known to increase the need for balancing. This article analyses whether wind turbines in the future should participate in the balancing markets and thereby play a proactive role. The analysis is based on a real-life test of proactive participation of a wind farm in West Denmark. It is found...... that the wind farm is able to play a proactive role regarding downward regulation and thereby increase profits....

  7. Human impacts on land cover and water balances in a coastal Mediterranean county.

    Science.gov (United States)

    Bellot, Juan; Bonet, Andreu; Peña, Juan; Sánchez, Juan Rafael

    2007-03-01

    We analyzed the effects of changes in land cover on the water balance in Spain's Marina Baixa County, on the Mediterranean coast. To reveal how different land management strategies have affected the area's environment, four municipalities within the same catchment were studied: Benidorm, Callosa d'en Sarrià, Beniardà, and Guadalest. In the municipalities of Callosa and Benidorm, the proportion of the area covered by woodland declined by 4.2% and 30.2%, respectively, and woodland was replaced by agriculture and urban development. The abandonment of farmland produced a 17% increase in the proportion of the area covered by vegetation in Guadalest and Beniardá, where frequent forest fires have exacerbated a decrease in the area of pine woodland. Tourism development in Benidorm has been accompanied by an increase in the transportation infrastructure and by an expansion of areas with an impermeable surface, with the lowest level of infiltration into the aquifer system. These changes have generated a net water deficit in Callosa and Benidorm of more than 6 Mm(3)/year, creating a high demand for water imported from other municipalities (Guadalest and Beniardá) or from outside of the county to maintain the sustainability of the current water management strategies. The Marina Baixa case study is representative of many of the world's coastal areas that are undergoing rapid urban development based on an inappropriate understanding of human progress based mainly on economic development and thus provides insights into water management in other areas.

  8. State dependent matrices and balanced energy functions for nonlinear systems

    NARCIS (Netherlands)

    Scherpen, Jacquelien M.A.; Gray, W. Steven

    2000-01-01

    The nonlinear extension of the balancing procedure requires the case of state dependent quadratic forms for the energy functions, i.e., the nonlinear extensions of the linear Gramians are state dependent matrices. These extensions have some interesting ambiguities that do not occur in the linear cas

  9. Modelling heavy metal and phosphorus balances for farming systems

    NARCIS (Netherlands)

    Keller, A.N.; Schulin, R.

    2003-01-01

    Accounting for agricultural activities such as P fertilization in regional models of heavy metal accumulation provides suitable sustainable management strategies to reduce nutrient surpluses and metal inputs in agricultural soils. Using the balance model PROTERRA-S, we assessed the phosphorus ( P),

  10. [Design of a mechanical system for the balanceable system of ambulance].

    Science.gov (United States)

    Zheng, Yi; Luo, Yibin; Zhang, Guangpeng; Zhang, Zhide; Chen, Chaomin

    2010-08-01

    This is the design of a mechanical systems for use in the balanceable system of ambulance, which can keep the medical service bed at the ambulance level, whatever the terrain is. A level detector will detect the level state of the bed and turn it to a signal. The central processing unit will use this signal to analyse and control the movement of the motor. By this design (which uses the rolling rail as a drive transmission and makes three supports of the bed go up and down), the bed will keep level. With the use of this design, the balanceable system of ambulance can counteract 35 degrees. The error is controlled within +/- 1 degree. And the response time is within 0.3 s. The method of registration can be effective for keeping the bed at the ambulance level, and for reducing the chance of making the patient get hurt on the way to hospital.

  11. Craniomandibular System and Postural Balance after 3-Day Dry Immersion.

    Directory of Open Access Journals (Sweden)

    Loïc Treffel

    Full Text Available The objective of the study was to determine the influence of simulated microgravity by exposure to dry immersion on the craniomandibular system. Twelve healthy male volunteers participated in a 3-day dry immersion study. Before and immediately after exposure we measured maximal bite force using piezoresistive sensors. The mechanical properties of the jaw and cervical muscles were evaluated before, during, and after dry immersion using MyotonPRO. Because recent studies reported the effects of jaw motor activity on the postural stability of humans, stabilometric measurements of center of pressure were performed before and after dry immersion in two mandibular positions: rest position without jaw clenching, and intercuspidal position during voluntary teeth clenching. Results revealed no significant changes of maximal bite force after dry immersion. All postural parameters were significantly altered by dry immersion. There were however no significant differences in stabilometric data according to mandibular position. Moreover the masseter tonicity increased immediately after the end of dry immersion period. Dry immersion could be used as a valid model for studying the effects of microgravity on human subjects. However, 3 days appear insufficient in duration to evaluate the effects of weightlessness on maximal bite force. Our research suggests a link between postural disturbance after dry immersion and masseter tonicity.

  12. Perturbation analysis of internal balancing for lightly damped mechanical systems with gyroscopic and circulatory forces

    Science.gov (United States)

    Blelloch, P. A.; Mingori, D. L.; Wei, J. D.

    1987-01-01

    Approximate expressions are developed for internally balanced singular values corresponding to the modes of mechanical systems with gyroscopic forces, light damping, and small circulatory forces. A brief overview is first given of the balanced realization model reduction method, including a discussion of recent work. The models considered are defined, and a perturbation analysis is used to show that the modal representation becomes asymptotically balanced as damping reduces to zero. The approximate balanced singular values are calculated, and a simple example of a flexible, dual-spin spacecraft is given as an illustration of the results.

  13. Human Exposure Database System (HEDS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Human Exposure Database System (HEDS) provides public access to data sets, documents, and metadata from EPA on human exposure. It is primarily intended for...

  14. New Real-Time Market Facilitating Demand-Side Resources for System Balancing

    DEFF Research Database (Denmark)

    Feng, Donghan; Nyeng, Preben; Xie, Jun;

    2011-01-01

    of such loads can deliver a well-behaved, stable and predictable balancing support. Based on a comprehensive analysis of the current balancing markets, as well as the technical properties of traditional and potential balancing resources, this paper proposes a new real-time balancing market setup facilitating....... This research is potentially useful for designing future balancing markets and utilizing demand response for system services. Copyright (C) 2011 Praise Worthy Prize S.r.l. - All rights reserved.......Many demand side resources have the potential to provide fast and low cost balancing services. Switching these devices on and off can be executed in seconds and have limited consequences for the customers if the duration is not long. With carefully designed market rules, tens of thousands...

  15. Multiagent system in automatic light power balance in optical networks

    Science.gov (United States)

    Å lapák, Martin; Hůla, Miloslav

    2013-09-01

    This article deals with automatic power balancing along an optical line. For optimal transmission of an optical signal it is important to achieve certain parameters such as the signal to noise ratio or chromatic dispersion and also the sufficient output power level of in-line amplifiers. Pump diodes in amplifiers suffer from aging of material and therefore the driving current of pump diodes has to be accordingly increased to achieve the same gain as in the moment when the pump diodes were new. The use of a minimal required driving current leads to the longer lifetime of optical pumps. Therefore an automatic power balance is one of the methods used to achieve these goals.

  16. The Notion of Structural Balance and the International System.

    Science.gov (United States)

    1972-01-01

    the theory of directed graphs is contained in Dorwin Cartwright and Frank Harary, "Structural Balance: A Generalization of Heider’s Theory," Psy ical...316- 323; and Frank Harary, Robert Z.Norman, and Dorwin Cartwright , Structural Models: An Introduction to the Theory of Directed Graphs (New York: john...concept is Harary, op. cit., 1959; and Harary, Norman and Cartwright , op. cit. p.-.,. 34 8James N. Rosenau, "Pre-theories and ’heories of Foreign

  17. Surface N Balances in Agricultural Crop production systems in China for the period 1980-2015

    NARCIS (Netherlands)

    Sun, B.; Shen, R.P.; Bouwman, A.F.

    2008-01-01

    Surface nitrogen (N) balances for China's crop production systems were estimated using statistical data collected from 1980 to 2004 at the national and provincial scale and from 1994 to 1999 at the county level. There was a surplus N balance throughout these periods, but the surplus was nearly stabl

  18. Linear quadratic Gaussian balancing for discrete-time infinite-dimensional linear systems

    NARCIS (Netherlands)

    Opmeer, MR; Curtain, RF

    2004-01-01

    In this paper, we study the existence of linear quadratic Gaussian (LQG)-balanced realizations for discrete-time infinite-dimensional systems. LQG-balanced realizations are those for which the smallest nonnegative self-adjoint solutions of the control and filter Riccati equations are equal. We show

  19. Development of management quality system for metallurgical enterprise based on Balanced Scorecard with limiting factors

    Directory of Open Access Journals (Sweden)

    Galina Ledneva

    2009-12-01

    Full Text Available The article considers inefficiency of the existing quality management systems (QMS based on standards ISO series 9000. The authors offer integrated QMS with limiting factors on Balanced Scorecard. The Balanced Scorecard with limiting factors helps to efficiently direct process of continuous improvement and achieve top-priority criteria in quality management domain.

  20. Detecting asymmetries in balance control in Parkinson's disease patients with system identification techniques.

    NARCIS (Netherlands)

    Boonstra, Tjitske; van Asseldonk, Edwin H.F.; van Vugt, J.P.P.; van der Kooij, Herman; Bloem, B.B.

    2009-01-01

    Objective: To test the hypothesis that balance control in Parkinson’s disease (PD) is asymmetrically affected using system identification techniques. Background: PD is an asymmetrical disease. It is unknown whether axial symptoms, such as impaired balance, also show asymmetry. Clinical scales used t

  1. Human Control Law and Brain Activity of Voluntary Motion by Utilizing a Balancing Task with an Inverted Pendulum

    Directory of Open Access Journals (Sweden)

    Satoshi Suzuki

    2010-01-01

    Full Text Available Human characteristics concerning voluntary motion control are investigated, because this motion is fundamental for the machine operation and human-computer system. Using a force feedback haptic device and a balancing task of a virtual inverted pendulum, participants were trained in the task, and hand motion/force was measured, and brain activity was monitored. First, through brain analysis by near-infrared spectroscopy (NIRS and motion analysis of the pendulum, we identified a participant who was the most expert. Next, control characteristics of the most expert were investigated by considering the operational force and delay factor of a human. As a result, it was found that predictive control based on velocity information was used predominantly although a perception feedback control against the pendulum posture worked. And it was shown that an on-off intermittency control, which was a strategy for the skilled balancing, can be described well by a liner model involving two types of time shifts for the position and velocity. In addition, it was confirmed that the cortex activity for observation in an ocular motor control area and visual processing area was strong to enhance above-mentioned control strategies.

  2. Assessment and intervention of human balance using balance master%平衡仪与人体平衡功能的评定及干预

    Institute of Scientific and Technical Information of China (English)

    马玉; 吴庆文; 马素慧; 董胜莲

    2012-01-01

    BACKGROUND: As the applying of computer-aided technology in the filed of balance function evaluation, new progress has been made in balance evaluation and training. OBJECTIVE: To summarize the progress and intervention strategy of balance function evaluation at home and abroad. METHODS: An online search of PubMed database and Chinese Journal Full-text Database was performed for related articles published between January 1996 and March 2011 with the key words of "Balance, Balance master, Postural control" in English and Chinese, respectively. Balance was used as the evaluation index. A total of 34 articles related to balance function were retained. RESULTS AND CONCLUSION: The research type of balance function changes from pure subjective qualitative study to objective quantitative assessment. Balance master, as an objective evaluation method, can quantitatively, objectively and accurately assess the status of patients balance. It develops balance training and guides the rehabilitation plan by visual feedback. Balance master plays an important role in the evaluation of rehabilitation effect. It is confirmed abroad that balance master is effective to improve human balance. Therefore, balance master is more and more used in clinical rehabilitation.%背景:随着计算机辅助技术在平衡功能评估领域的应用,平衡的评定和训练有了新的发展.目的:总结国内外平衡能力评估的研究进展及干预策略.方法:以"Balance,Balance master,Postural control"为检索词检索PubMed数据库(1996-01/2011-03);以"平衡,平衡仪,姿势控制"为检索词检索中国期刊全文数据库(1996-01/2011-03)的相关文章,对资料进行初审,以平衡能力相关的文献为评价标准,纳入与平衡能力相关的34个研究进行综述.结果与结论:康复医学中平衡功能的研究正从单纯的主观定性研究向客观定量评估转变,平衡仪作为一种客观评定方法,可以定量、客观、准确地评

  3. System Identification and Automatic Mass Balancing of Ground-Based Three-Axis Spacecraft Simulator

    Science.gov (United States)

    2006-08-01

    System Identification and Automatic Mass Balancing of Ground-Based Three-Axis Spacecraft Simulator Jae-Jun Kim∗ and Brij N. Agrawal † Department of...TITLE AND SUBTITLE System Identification and Automatic Mass Balancing of Ground-Based Three-Axis Spacecraft Simulator 5a. CONTRACT NUMBER 5b...and Dynamics, Vol. 20, No. 4, July-August 1997, pp. 625-632. 6Schwartz, J. L. and Hall, C. D., “ System Identification of a Spherical Air-Bearing

  4. ANALYTIC NETWORK PROCESS AND BALANCED SCORECARD APPLIED TO THE PERFORMANCE EVALUATION OF PUBLIC HEALTH SYSTEMS

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Reis dos Santos

    2015-08-01

    Full Text Available The performance of public health systems is an issue of great concern. After all, to assure people's quality of life, public health systems need different kinds of resources. Balanced Scorecard provides a multi-dimensional evaluation framework. This paper presents the application of the Analytic Network Process and Balanced Scorecard in the performance evaluation of a public health system in a typical medium-sized Southeastern town in Brazil.

  5. WALK-ASSISTING BALANCE SYSTEM OF THE EXOSKELETON ROBOT FOR DISABLED PEOPLE

    Institute of Scientific and Technical Information of China (English)

    Yin Yuehong; Zhou Chunlin; Song Jiaren; Chen Shiyi; Han Tianpu; Zhou Chen

    2004-01-01

    A novel methodology for a walk-assisting balance system of the exoskeleton robot for disabled people is presented.The experiment on the walk-assisting balance system is implemented using a mini-type ropewalker robot.The mechanism of the ropewalker robot is designed,its dynamic model is built,and its control system based on PWM is developed.The emulations in Matlab and the results of experiments prove that this methodology is effective.

  6. Energy balance in olive oil farms: comparison of organic and conventional farming systems.

    Science.gov (United States)

    Moreno, Marta M.; Meco, Ramón; Moreno, Carmen

    2013-04-01

    The viability of an agricultural production system not only depends on the crop yields, but especially on the efficient use of available resources. However, the current agricultural systems depend heavily on non-renewable energy consumption in the form of fertilizers, fossil fuels, pesticides and machinery. In developed countries, the economic profitability of different productive systems is dependent on the granting of subsidies of diverse origin that affect both production factors (or inputs) and the final product (or output). Leaving such external aids, energy balance analysis reveals the real and most efficient form of management for each agroclimatic region, and is also directly related to the economic activity and the environmental state. In this work we compare the energy balance resulting from organic and conventional olive oil farms under the semi-arid conditions of Central Spain. The results indicate that the mean energy supplied to the organic farms was sensitively lower (about 30%) in comparison with the conventional management, and these differences were more pronounced for the biggest farms (> 15 ha). Mean energy outputs were about 20% lower in the organic system, although organic small farms (< 15 ha) resulted more productive than the conventional small ones. However, these lower outputs were compensated by the major market value obtained from the organic products. Chemical fertilizers and pesticides reached about 60% of the total energy inputs in conventional farming; in the organic farms, however, this ratio scarcely reached 25%. Human labor item only represented a very small amount of the total energy input in both cases (less than 1%). As conclusions, both management systems were efficient from an energy point of view. The value of the organic production should be focused on the environmental benefits it provides, which are not usually considered in the conventional management on not valuing the damage it produces to the environment. Organic

  7. The Balanced Company

    DEFF Research Database (Denmark)

    through control or trust. Human resource specialists need to make balanced decisions about how to design tasks and jobs in order to make them attractive as well as motivating. Marketers need to make balanced decisions about how to market products in the light of what is now important in consumers...... in their environments. Communication specialists need to make balanced decisions which take the different value systems and assumptions of stakeholders into consideration. Change specialists need to balance the need for continuity and change. Managers need to make balanced decisions about whether to achieve goals......' and other stakeholder's eyes. Leaders also have to acknowledge that there are times when organizations have to be taken out of balance, since it is necessary to 'unfreeze' existing relationships in organizations during change. Therefore, there are decision and organizing processes involved in both...

  8. Human factors systems approach to healthcare quality and patient safety

    Science.gov (United States)

    Carayon, Pascale; Wetterneck, Tosha B.; Rivera-Rodriguez, A. Joy; Hundt, Ann Schoofs; Hoonakker, Peter; Holden, Richard; Gurses, Ayse P.

    2013-01-01

    Human factors systems approaches are critical for improving healthcare quality and patient safety. The SEIPS (Systems Engineering Initiative for Patient Safety) model of work system and patient safety is a human factors systems approach that has been successfully applied in healthcare research and practice. Several research and practical applications of the SEIPS model are described. Important implications of the SEIPS model for healthcare system and process redesign are highlighted. Principles for redesigning healthcare systems using the SEIPS model are described. Balancing the work system and encouraging the active and adaptive role of workers are key principles for improving healthcare quality and patient safety. PMID:23845724

  9. Storage and balancing synergies in a fully or highly renewable pan-European power system

    DEFF Research Database (Denmark)

    Rasmussen, Morten Grud; Bruun Andresen, Gorm; Greiner, Martin

    2012-01-01

    Through a parametric time-series analysis of eight years of hourly data, we quantify the storage size and balancing energy needs for highly and fully renewable European power systems for different levels and mixes of wind and solar energy. By applying a dispatch strategy that minimizes...... that combined with a low-efficiency hydrogen storage and a level of balancing equal to what is today provided by storage lakes, it is sufficient to meet the European electricity demand in a fully renewable power system where the average power generation from combined wind and solar exceeds the demand by only...... the balancing energy needs for a given storage size, the interplay between storage and balancing is quantified, providing a hard upper limit on their synergy. An efficient but relatively small storage reduces balancing energy needs significantly due to its influence on intra-day mismatches. Furthermore, we show...

  10. Design and diffusion of systems for human benefit

    CERN Document Server

    Venable, John R; Bunker, Deborah

    2011-01-01

    Information systems have the potential to provide human benefit in a number of areas including: improvement of education, provision of social and other services to the public, health and well-being, work-life balance, environmental sustainability, democracy and self-determination, freedom, emancipation, poverty reduction, and social equity. However, most studies within Information Systems relate to a business context rather than directly to human benefit. When dealing with human benefit, system stakeholders may have different objectives regarding a system's use, its distribution, and the way r

  11. 企业人力资源结构失衡现象略析%On Phenomenon of Losing Balance of Enterprises’ Human Resource Structure

    Institute of Scientific and Technical Information of China (English)

    耿锦卉

    2014-01-01

    The lost of balance of human resource in the enterprise is a kind of inherent economic phenom-enon, which includes the negative factors and positive factors .The lost of balance of human resource in enter-prise will influence the enterprise ’ s administrative system directly .We should take some effective actions on the lost of balance of enterprise ’ s administration .%企业人力资源结构失衡是一种固有的经济现象,既有消极影响,也有积极因素。企业人力资源结构失衡将直接影响企业管理系统的正常运行。企业应在失衡管理方面积极有所作为。

  12. A Balanced-Fed Dual Inverted-F Antenna with Reduced Human Body Effects

    Directory of Open Access Journals (Sweden)

    Wang-Sang Lee

    2013-01-01

    Full Text Available A balanced-fed dual inverted-F antenna with reduced human body effects for WLAN applications at 2.45 GHz is presented. In order to reduce the influence by a close proximity or a touch of a human body, the proposed antenna employs an impedance matching using a lumped LC-balun which has the simple and compact structure applying for mobile handsets. The resonant frequency of the proposed antenna is fixed at 2.45 GHz regardless of the close proximity of a human body. By applying for the L-shape ground plane, the proposed antenna has the wide impedance bandwidth of about 150 MHz and the peak realized gain of about 4 dBi.

  13. New PN Even Balanced Sequences for Spread-Spectrum Systems

    Directory of Open Access Journals (Sweden)

    Inácio JAL

    2005-01-01

    Full Text Available A new class of pseudonoise even balanced (PN-EB binary spreading sequences is derived from existing classical odd-length families of maximum-length sequences, such as those proposed by Gold, by appending or inserting one extra-zero element (chip to the original sequences. The incentive to generate large families of PN-EB spreading sequences is motivated by analyzing the spreading effect of these sequences from a natural sampling point of view. From this analysis a new definition for PG is established, from which it becomes clear that very high processing gains (PGs can be achieved in band-limited direct-sequence spread-spectrum (DSSS applications by using spreading sequences with zero mean, given that certain conditions regarding spectral aliasing are met. To obtain large families of even balanced (i.e., equal number of ones and zeros sequences, two design criteria are proposed, namely the ranging criterion (RC and the generating ranging criterion (GRC. PN-EB sequences in the polynomial range are derived using these criteria, and it is shown that they exhibit secondary autocorrelation and cross-correlation peaks comparable to the sequences they are derived from. The methods proposed not only facilitate the generation of large numbers of new PN-EB spreading sequences required for CDMA applications, but simultaneously offer high processing gains and good despreading characteristics in multiuser SS scenarios with band-limited noise and interference spectra. Simulation results are presented to confirm the respective claims made.

  14. Integrated Balanced BPSK Modulator for Millimeter Wave Systems

    Directory of Open Access Journals (Sweden)

    Asok De

    2007-10-01

    Full Text Available This paper details the design of integrated balanced PSK modulator using finline coplanar line hybrid junction. The PSK signal output is in suspended stripline with incident wave carrier in finline. Schottky barrier Diode MA4E2037 has been used for modulation. The balanced configuration offers high isolation between the carrier input port and the modulated carrier output port and thus the pulse width variations and amplitude deviations are suppressed. An insertion loss imbalance of ±1.5 dB with an average loss of 2 dB in the two switching states has been achieved over 38.9 to 40 GHz. The phase imbalance is ±10 degrees with phase switching from 180 to 199 degrees As the PSK output signal is in suspended stripline, two BPSK modulators can be easily combined together to work as QPSK modulator.

  15. Workload Balancing on Heterogeneous Systems: A Case Study of Sparse Grid Interpolation

    KAUST Repository

    Muraraşu, Alin

    2012-01-01

    Multi-core parallelism and accelerators are becoming common features of today’s computer systems, as they allow for computational power without sacrificing energy efficiency. Due to heterogeneity, tuning for each type of compute unit and adequate load balancing is essential. This paper proposes static and dynamic solutions for load balancing in the context of an application for visualizing high-dimensional simulation data. The application relies on the sparse grid technique for data compression. Its performance critical part is the interpolation routine used for decompression. Results show that our load balancing scheme allows for an efficient acceleration of interpolation on heterogeneous systems containing multi-core CPUs and GPUs.

  16. Impact of climate forcing uncertainty and human water use on global and continental water balance components

    Science.gov (United States)

    Müller Schmied, Hannes; Adam, Linda; Eisner, Stephanie; Fink, Gabriel; Flörke, Martina; Kim, Hyungjun; Oki, Taikan; Portmann, Felix Theodor; Reinecke, Robert; Riedel, Claudia; Song, Qi; Zhang, Jing; Döll, Petra

    2016-10-01

    The assessment of water balance components using global hydrological models is subject to climate forcing uncertainty as well as to an increasing intensity of human water use within the 20th century. The uncertainty of five state-of-the-art climate forcings and the resulting range of cell runoff that is simulated by the global hydrological model WaterGAP is presented. On the global land surface, about 62 % of precipitation evapotranspires, whereas 38 % discharges into oceans and inland sinks. During 1971-2000, evapotranspiration due to human water use amounted to almost 1 % of precipitation, while this anthropogenic water flow increased by a factor of approximately 5 between 1901 and 2010. Deviation of estimated global discharge from the ensemble mean due to climate forcing uncertainty is approximately 4 %. Precipitation uncertainty is the most important reason for the uncertainty of discharge and evapotranspiration, followed by shortwave downward radiation. At continental levels, deviations of water balance components due to uncertain climate forcing are higher, with the highest discharge deviations occurring for river discharge in Africa (-6 to 11 % from the ensemble mean). Uncertain climate forcings also affect the estimation of irrigation water use and thus the estimated human impact of river discharge. The uncertainty range of global irrigation water consumption amounts to approximately 50 % of the global sum of water consumption in the other water use sector.

  17. The Balanced Scorecard: A Management System for Wilford Hall Medical Center - The Premier Air Force Medical Enterprise

    Science.gov (United States)

    1999-04-01

    The Balanced Scorecard Management System (BSMS) at Wilford Hall Medical Center (WHMC) is a strategic management and measurement system that...prompted the study to a look at the statement of the problem, the author explores the history and use of the balanced scorecard concept in civilian...was an Intranet-based, database automated, Balanced Scorecard Management System.

  18. Balance Sheet and Analysis of Reactive Power Demand in the Polish Power System

    Directory of Open Access Journals (Sweden)

    Aleksander Kot

    2013-03-01

    Full Text Available The paper presents an analysis of the balance sheet and the reactive power demand of the Polish Power System. Reactive power balance sheets were made for the specific operating conditions of the system: the last winter peak, summer peak and summer off peak load. The basis of the study was load flow models and selected load flow calculation results. In addition, changes in demand for active and reactive power in recent years were presented.

  19. Cost of photovoltaic energy systems as determined by balance-of-system costs

    Science.gov (United States)

    Rosenblum, L.

    1978-01-01

    The effect of the balance-of-system (BOS), i.e., the total system less the modules, on photo-voltaic energy system costs is discussed for multikilowatt, flat-plate systems. Present BOS costs are in the range of 10 to 16 dollars per peak watt (1978 dollars). BOS costs represent approximately 50% of total system cost. The possibility of future BOS cost reduction is examined. It is concluded that, given the nature of BOS costs and the lack of comprehensive national effort focussed on cost reduction, it is unlikely that BOS costs will decline greatly in the next several years. This prognosis is contrasted with the expectations of the Department of Energy National Photovoltaic Program goals and pending legislation in the Congress which require a BOS cost reduction of an order of magnitude or more by the mid-1980s.

  20. Mechanical design of a rotary balance system for NASA. Langley Research Center's vertical spin tunnel

    Science.gov (United States)

    Allred, J. W.; Fleck, V. J.

    1992-01-01

    A new lightweight Rotary Balance System is presently being fabricated and installed as part of a major upgrade to the existing 20 Foot Vertical Spin Tunnel. This upgrade to improve model testing productivity of the only free spinning vertical wind tunnel includes a modern fan/drive and tunnel control system, an updated video recording system, and the new rotary balance system. The rotary balance is a mechanical apparatus which enables the measurement of aerodynamic force and moment data under spinning conditions (100 rpm). This data is used in spin analysis and is vital to the implementation of large amplitude maneuvering simulations required for all new high performance aircraft. The new rotary balance system described in this report will permit greater test efficiency and improved data accuracy. Rotary Balance testing with the model enclosed in a tare bag can also be performed to obtain resulting model forces from the spinning operation. The rotary balance system will be stored against the tunnel sidewall during free flight model testing.

  1. Storage Balancing in Self-organizing Multimedia Delivery Systems

    CERN Document Server

    Sobe, Anita; Böszörmenyi, Laszlo

    2011-01-01

    Many of the current bio-inspired delivery networks set their focus on search, e.g., by using artificial ants. If the network size and, therefore, the search space gets too large, the users experience high delays until the requested content can be consumed. In previous work, we proposed different replication strategies to reduce the search space. In this report we further evaluate measures for storage load balancing, because peers are most likely limited in space. We periodically apply clean-ups if a certain storage level is reached. For our evaluations we combine the already introduced replication measures with least recently used (LRU), least frequently used (LFU) and a hormone-based clean-up. The goal is to elaborate a combination that leads to low delays while the replica utilization is high.

  2. Energy balance of five fodder cropping systems in the irrigated lowlands of Northern Italy

    Directory of Open Access Journals (Sweden)

    Cesare Tomasoni

    2011-03-01

    Full Text Available Extensification has recently become an important option in Western European agriculture, driven both by economic considerations (product surpluses together with the fact that developed countries cropping systems have been heavily relying on fossil energy and growing public concern on the possible adverse effects of intensive farming on the environment and human health. The adoption of rational fodder crop rotations, with the rediscovery of the beneficial effect of the meadow, is viewed as a possible mean to reduce the impact of farming systems in the lowlands of Northern Italy, characterised by highly intensive cropping and animal husbandry. For this reason our study examines the effects of crop rotation on the energy balance during 1985-2007 period in a long-term crop rotation trial in Northern Italy comparing five fodder crop systems, different in the degree of crop intensification and for the presence or absence of the meadow: a 1-year continuous cereal double cropping (R1; a 3-year rotation (R3; a 6-year rotation (R6; a permanent meadow (PM; and a continuous grain maize cropping (CM. Each rotation was subjected to two input treatments, defined as high (mostly used in lowlands of northern Italy and low (input reduction of ca. 30% respectively, in terms of nutrient levels, herbicide doses, and soil tillage methods. The crop rotations exerted a marked influence on the energy balance. The most efficient rotations in terms of net energy production energy efficiency have been characterized by reduced length and presence of maize and catch-crops.

  3. New PN Even Balanced Sequences for Spread-Spectrum Systems

    Directory of Open Access Journals (Sweden)

    Inácio J. A. L.

    2005-01-01

    Full Text Available A new class of pseudonoise even balanced (PN-EB binary spreading sequences is derived from existing classical odd-length families of maximum-length sequences, such as those proposed by Gold, by appending or inserting one extra-zero element (chip to the original sequences. The incentive to generate large families of PN-EB spreading sequences is motivated by analyzing the spreading effect of these sequences from a natural sampling point of view. From this analysis a new definition for PG is established, from which it becomes clear that very high processing gains (PGs can be achieved in band-limited direct-sequence spread-spectrum (DSSS applications by using spreading sequences with zero mean, given that certain conditions regarding spectral aliasing are met. To obtain large families of even balanced (i.e., equal number of ones and zeros sequences, two design criteria are proposed, namely the ranging criterion (RC and the generating ranging criterion (GRC. PN-EB sequences in the polynomial range 3 ≤ n ≤ 6 are derived using these criteria, and it is shown that they exhibit secondary autocorrelation and cross-correlation peaks comparable to the sequences they are derived from. The methods proposed not only facilitate the generation of large numbers of new PN-EB spreading sequences required for CDMA applications, but simultaneously offer high processing gains and good despreading characteristics in multiuser SS scenarios with band-limited noise and interference spectra. Simulation results are presented to confirm the respective claims made.

  4. Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection.

    Directory of Open Access Journals (Sweden)

    Matthew J Kesic

    Full Text Available Exposure to oxidant air pollution is associated with increased respiratory morbidities and susceptibility to infections. Ozone is a commonly encountered oxidant air pollutant, yet its effects on influenza infections in humans are not known. The greater Mexico City area was the primary site for the spring 2009 influenza A H1N1 pandemic, which also coincided with high levels of environmental ozone. Proteolytic cleavage of the viral membrane protein hemagglutinin (HA is essential for influenza virus infectivity. Recent studies suggest that HA cleavage might be cell-associated and facilitated by the type II transmembrane serine proteases (TTSPs human airway trypsin-like protease (HAT and transmembrane protease, serine 2 (TMPRSS2, whose activities are regulated by antiproteases, such as secretory leukocyte protease inhibitor (SLPI. Based on these observations, we sought to determine how acute exposure to ozone may modulate cellular protease/antiprotease expression and function, and to define their roles in a viral infection. We utilized our in vitro model of differentiated human nasal epithelial cells (NECs to determine the effects of ozone on influenza cleavage, entry, and replication. We show that ozone exposure disrupts the protease/antiprotease balance within the airway liquid. We also determined that functional forms of HAT, TMPRSS2, and SLPI are secreted from human airway epithelium, and acute exposure to ozone inversely alters their expression levels. We also show that addition of antioxidants significantly reduces virus replication through the induction of SLPI. In addition, we determined that ozone-induced cleavage of the viral HA protein is not cell-associated and that secreted endogenous proteases are sufficient to activate HA leading to a significant increase in viral replication. Our data indicate that pre-exposure to ozone disrupts the protease/antiprotease balance found in the human airway, leading to increased influenza susceptibility.

  5. Responsiveness of the Balance Evaluation Systems Test (BESTest) in People With Subacute Stroke.

    Science.gov (United States)

    Chinsongkram, Butsara; Chaikeeree, Nithinun; Saengsirisuwan, Vitoon; Horak, Fay B; Boonsinsukh, Rumpa

    2016-10-01

    The reliability and convergent validity of the Balance Evaluation Systems Test (BESTest) in people with subacute stroke have been established, but its responsiveness to rehabilitation has not been examined. The study objective was to compare the responsiveness of the BESTest with those of other clinical balance tools in people with subacute stroke. This was a prospective cohort study. Forty-nine people with subacute stroke (mean age=57.8 years, SD=11.8) participated in this study. Five balance measures-the BESTest, the Mini-BESTest, the Berg Balance Scale, the Postural Assessment Scale for Stroke Patients, and the Community Balance and Mobility Scale (CB&M)-were used to measure balance performance before and after rehabilitation or before discharge from the hospital, whichever came first. The internal responsiveness of each balance measure was classified with the standardized response mean (SRM); changes in Berg Balance Scale scores of greater than 7 were used as the external standard for determining the external responsiveness. Analysis of the receiver operating characteristic curve was used to determine the accuracy and cutoff scores for identifying participants with balance improvement. Participants received 13.7 days (SD=9.3, range=5-44) of physical therapy rehabilitation. The internal responsiveness of all balance measures, except for the CB&M, was high (SRM=0.9-1.2). The BESTest had a higher SRM than the Mini-BESTest and the CB&M, indicating that the BESTest was more sensitive for detecting balance changes than the Mini-BESTest and the CB&M. In addition, compared with other balance measures, the BESTest had no floor, ceiling, or responsive ceiling effects. The results also indicated that the percentage of participants with no change in scores after rehabilitation was smaller with the BESTest than with the Mini-BESTest and the CB&M. With regard to the external responsiveness, the BESTest had higher accuracy, sensitivity, specificity, and posttest accuracy than

  6. Disorder in Complex Human System

    Science.gov (United States)

    Akdeniz, K. Gediz

    2011-11-01

    Since the world of human and whose life becomes more and more complex every day because of the digital technology and under the storm of knowledge (media, internet, governmental and non-governmental organizations, etc...) the simulation is rapidly growing in the social systems and in human behaviors. The formation of the body and mutual interactions are left to digital technological, communication mechanisms and coding the techno genetics of the body. Deconstruction begins everywhere. The linear simulation mechanism with modern realities are replaced by the disorder simulation of human behaviors with awareness realities. In this paper I would like to introduce simulation theory of "Disorder Sensitive Human Behaviors". I recently proposed this theory to critique the role of disorder human behaviors in social systems. In this theory the principle of realty is the chaotic awareness of the complexity of human systems inside of principle of modern thinking in Baudrillard's simulation theory. Proper examples will be also considered to investigate the theory.

  7. Human neutrophil alloantigens systems

    Directory of Open Access Journals (Sweden)

    Elyse Moritz

    2009-09-01

    Full Text Available Neutrophil alloantigens are involved in a variety of clinical conditions including immune neutropenias, transfusion-related acute lung injury (TRALI, refractoriness to granulocyte transfusions and febrile transfusion reactions. In the last decade, considerable progress has been made in the characterization of the implicated antigens. Currently, seven antigens are assigned to five human neutrophil antigen (HNA systems. The HNA-1a, HNA-1b and HNA-1c antigens have been identified as polymorphic forms of the neutrophil Fcγ receptor IIIb (CD16b, encoded by three alleles. Recently, the primary structure of the HNA-2a antigen was elucidated and the HNA-2a-bearing glycoprotein was identified as a member of the Ly-6/uPAR superfamily, which has been clustered as CD177. The HNA-3a antigen is located on a 70-95 kDa glycoprotein; however, its molecular basis is still unknown. Finally, the HNA-4a and HNA-5a antigens were found to be caused by single nucleotide mutations in the αM (CD11b and αL (CD11a subunits of the leucocyte adhesion molecules (β2 integrins. Molecular and biochemical characterization of neutrophil antigenshave expanded our diagnostic tools by the introduction of genotyping techniques and immunoassays for antibody identification. Further studies in the field of neutrophil immunology will facilitate the prevention and management of transfusion reactions and immune diseases caused by neutrophil antibodies.Os aloantígenos de neutrófilos estão associados a várias condições clínicas como neutropenias imunes, insuficiência pulmonar relacionada à transfusão (TRALI, refratariedade à transfusão de granulócitos, e reações transfusionais febris. Na última década, foi observado considerável progresso na caracterização dos aloantígenos envolvidos nestas condições clínicas. Atualmente sete antígenos estão incluídos em cinco sistemas de antígenos de neutrófilo humano (HNA. Os antígenos HNA-1a, HNA-1b e HNA-1c foram

  8. Workload balancing capability of pull systems in MTO production

    NARCIS (Netherlands)

    Germs, R.; Riezebos, J.

    2010-01-01

    Pull systems focusing on throughput time control and applicable in situations with high variety and customisation are scarce. This paper compares three unit-based pull systems that can cope with such situations: POLCA, CONWIP and m-CONWIP. These systems control the shop floor throughput time of orde

  9. Workload balancing capability of pull systems in MTO production

    NARCIS (Netherlands)

    Germs, R.; Riezebos, J.

    2010-01-01

    Pull systems focusing on throughput time control and applicable in situations with high variety and customisation are scarce. This paper compares three unit-based pull systems that can cope with such situations: POLCA, CONWIP and m-CONWIP. These systems control the shop floor throughput time of

  10. An optimal state estimation model of sensory integration in human postural balance

    Science.gov (United States)

    Kuo, Arthur D.

    2005-09-01

    We propose a model for human postural balance, combining state feedback control with optimal state estimation. State estimation uses an internal model of body and sensor dynamics to process sensor information and determine body orientation. Three sensory modalities are modeled: joint proprioception, vestibular organs in the inner ear, and vision. These are mated with a two degree-of-freedom model of body dynamics in the sagittal plane. Linear quadratic optimal control is used to design state feedback and estimation gains. Nine free parameters define the control objective and the signal-to-noise ratios of the sensors. The model predicts statistical properties of human sway in terms of covariance of ankle and hip motion. These predictions are compared with normal human responses to alterations in sensory conditions. With a single parameter set, the model successfully reproduces the general nature of postural motion as a function of sensory environment. Parameter variations reveal that the model is highly robust under normal sensory conditions, but not when two or more sensors are inaccurate. This behavior is similar to that of normal human subjects. We propose that age-related sensory changes may be modeled with decreased signal-to-noise ratios, and compare the model's behavior with degraded sensors against experimental measurements from older adults. We also examine removal of the model's vestibular sense, which leads to instability similar to that observed in bilateral vestibular loss subjects. The model may be useful for predicting which sensors are most critical for balance, and how much they can deteriorate before posture becomes unstable.

  11. The Balanced Scorecard: a strategic management system for multi-sector collaboration and strategy implementation.

    Science.gov (United States)

    Inamdar, S N; Kaplan, R S; Jones, M L; Menitoff, R

    2000-01-01

    This article illustrates the application of the Balanced Scorecard, a method more commonly associated with the business world, to a nonprofit multisector National Women's Health Quality Initiative (NWHQI). The article delineates the following multiple uses of the Balanced Scorecard for the NWHQI effort: Set NWHQI strategy and structure. Provide the framework and principles to implement NWHQI's strategy. Develop a measurement system to assess the progress and success of NWHQI's strategy. Serve as a collaboration mechanism for multisector stakeholders. Advance women's health knowledge base. This article concludes by sharing key insights regarding the utility of the Balanced Scorecard to promote the success of this nationwide women's health quality initiative.

  12. Recent Developments In Theory Of Balanced Linear Systems

    Science.gov (United States)

    Gawronski, Wodek

    1994-01-01

    Report presents theoretical study of some issues of controllability and observability of system represented by linear, time-invariant mathematical model of the form. x = Ax + Bu, y = Cx + Du, x(0) = xo where x is n-dimensional vector representing state of system; u is p-dimensional vector representing control input to system; y is q-dimensional vector representing output of system; n,p, and q are integers; x(0) is intial (zero-time) state vector; and set of matrices (A,B,C,D) said to constitute state-space representation of system.

  13. An Integrated Simulation Tool for Modeling the Human Circulatory System

    Science.gov (United States)

    Asami, Ken'ichi; Kitamura, Tadashi

    This paper presents an integrated simulation of the circulatory system in physiological movement. The large circulatory system model includes principal organs and functional units in modules in which comprehensive physiological changes such as nerve reflexes, temperature regulation, acid/base balance, O2/CO2 balance, and exercise are simulated. A beat-by-beat heart model, in which the corresponding electrical circuit problems are solved by a numerical analytic method, enables calculation of pulsatile blood flow to the major organs. The integration of different perspectives on physiological changes makes this simulation model applicable for the microscopic evaluation of blood flow under various conditions in the human body.

  14. Life cycle inventory and mass-balance of municipal food waste management systems: Decision support methods beyond the waste hierarchy.

    Science.gov (United States)

    Edwards, Joel; Othman, Maazuza; Crossin, Enda; Burn, Stewart

    2017-08-14

    When assessing the environmental and human health impact of a municipal food waste (FW) management system waste managers typically rely on the principles of the waste hierarchy; using metrics such as the mass or rate of waste that is 'prepared for recycling,' 'recovered for energy,' or 'sent to landfill.' These metrics measure the collection and sorting efficiency of a waste system but are incapable of determining the efficiency of a system to turn waste into a valuable resource. In this study a life cycle approach was employed using a system boundary that includes the entire waste service provision from collection to safe end-use or disposal. A life cycle inventory of seven waste management systems was calculated, including the first service wide inventory of FW management through kitchen in-sink disposal (food waste disposer). Results describe the mass, energy and water balance of each system along with key emissions profile. It was demonstrated that the energy balance can differ significantly from its' energy generation, exemplified by mechanical biological treatment, which was the best system for generating energy from waste but only 5(th) best for net-energy generation. Furthermore, the energy balance of kitchen in-sink disposal was shown to be reduced because 31% of volatile solids were lost in pre-treatment. The study also confirmed that higher FW landfill diversion rates were critical for reducing many harmful emissions to air and water. Although, mass-balance analysis showed that the alternative end-use of the FW material may still contain high impact pollutants. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  15. Constructing an Efficient and Balanced European Patent System: “Muddling through”

    DEFF Research Database (Denmark)

    Schovsbo, Jens Hemmingsen

    2011-01-01

    The paper discusses ways to construct a more efficient and balanced European patent system. It identifies and describes challenges relating to innovation, to non-economic issues and to governance. In order to improve the patent system, a cautious approach of “Muddling through” is recommended. Mor...... access to patented inventions and enhancement of governance.......The paper discusses ways to construct a more efficient and balanced European patent system. It identifies and describes challenges relating to innovation, to non-economic issues and to governance. In order to improve the patent system, a cautious approach of “Muddling through” is recommended. More...

  16. Human Systems Roadmap Review

    Science.gov (United States)

    2016-02-09

    areas produce life long disability Problem: The combination of jet fuel and high noise environment can exacerbate hearing loss Objective: Expose...Personalized Assessment, Education , and Training Systems Interfaces and Cognitive Processes Protection, Sustainment, and Warfighter...Infrastructure, & Information Distribution Statement A: Approved for Public Release 4 Personalized Assessment, Education , and Training System

  17. A balanced Kalman filter ocean data assimilation system with application to the South Australian Sea

    Science.gov (United States)

    Li, Yi; Toumi, Ralf

    2017-08-01

    In this paper, an Ensemble Kalman Filter (EnKF) based regional ocean data assimilation system has been developed and applied to the South Australian Sea. This system consists of the data assimilation algorithm provided by the NCAR Data Assimilation Research Testbed (DART) and the Regional Ocean Modelling System (ROMS). We describe the first implementation of the physical balance operator (temperature-salinity, hydrostatic and geostrophic balance) to DART, to reduce the spurious waves which may be introduced during the data assimilation process. The effect of the balance operator is validated in both an idealised shallow water model and the ROMS model real case study. In the shallow water model, the geostrophic balance operator eliminates spurious ageostrophic waves and produces a better sea surface height (SSH) and velocity analysis and forecast. Its impact increases as the sea surface height and wind stress increase. In the real case, satellite-observed sea surface temperature (SST) and SSH are assimilated in the South Australian Sea with 50 ensembles using the Ensemble Adjustment Kalman Filter (EAKF). Assimilating SSH and SST enhances the estimation of SSH and SST in the entire domain, respectively. Assimilation with the balance operator produces a more realistic simulation of surface currents and subsurface temperature profile. The best improvement is obtained when only SSH is assimilated with the balance operator. A case study with a storm suggests that the benefit of the balance operator is of particular importance under high wind stress conditions. Implementing the balance operator could be a general benefit to ocean data assimilation systems.

  18. Impact of the Group Lifestyle Balance (GLB) Program on Diabetes Prevention in the Military Health System

    Science.gov (United States)

    2016-05-20

    TITLE OF MATERIAL TO BE PUBLISHED OR PRESENTED Impact of the Group Lifestyle Balance (GLB) Program on Diabetes Prevention in the Military Health...of 3 Pages IMPACT OF THE GROUP LIFESTYLE BALANCE (GLB) PROGRAM ON DIABETES PREVENTION IN THE MILITARY HEALTH SYSTEM Maj Richard Davis, MD1; Col Mark...The Diabetes Prevention Program (OPP) demonstrated lifestyle intervention programs were effective. The GLB program translated the OPP curriculum

  19. Management Information System Based on the Balanced Scorecard

    Science.gov (United States)

    Kettunen, Juha; Kantola, Ismo

    2005-01-01

    Purpose: This study seeks to describe the planning and implementation in Finland of a campus-wide management information system using a rigorous planning methodology. Design/methodology/approach: The structure of the management information system is planned on the basis of the management process, where strategic management and the balanced…

  20. Human-System task integration

    NARCIS (Netherlands)

    Schraagen, J.M.C.

    2005-01-01

    The Dutch Ministry of Defence research programme Human-System Task Integration aims at acquiring knowledge for the optimal cooperation between human and computer, under the following constraints: freedom of choice in decisions to automate and multiple, dynamic task distributions. This paper describe

  1. Constrained Balancing of Two Industrial Rotor Systems: Least Squares and Min-Max Approaches

    Directory of Open Access Journals (Sweden)

    Bin Huang

    2009-01-01

    Full Text Available Rotor vibrations caused by rotor mass unbalance distributions are a major source of maintenance problems in high-speed rotating machinery. Minimizing this vibration by balancing under practical constraints is quite important to industry. This paper considers balancing of two large industrial rotor systems by constrained least squares and min-max balancing methods. In current industrial practice, the weighted least squares method has been utilized to minimize rotor vibrations for many years. One of its disadvantages is that it cannot guarantee that the maximum value of vibration is below a specified value. To achieve better balancing performance, the min-max balancing method utilizing the Second Order Cone Programming (SOCP with the maximum correction weight constraint, the maximum residual response constraint as well as the weight splitting constraint has been utilized for effective balancing. The min-max balancing method can guarantee a maximum residual vibration value below an optimum value and is shown by simulation to significantly outperform the weighted least squares method.

  2. Evaluation of surface energy and radiation balance systems on the Konza Prairie

    Science.gov (United States)

    Fritschen, Leo J.

    1987-01-01

    Four Surface Energy and Radiation Balance Systems (SERBS) were installed and operated for two weeks in Kansas during July of 1986. Surface energy and radiation balances were investigated on six sites on the Konza Prairie about 3 km south of Manhattan, Kansas. Measurements were made to allow the computation of these radiation components: total solar and diffuse radiation, reflected solar radiation, net radiation, and longwave radiation upward and downward. Measurements were made to allow the computation of the sensible and latent heat fluxes by the Bowen ratio method using differential psychrometers on automatic exchange mechanisms. The report includes a description of the experimental sites, data acquisition systems and sensors, data acquisitions system operating instructions, and software used for data acquisition and analysis. In addition, data listings and plots of the energy balance components for all days and systems are given.

  3. Early effect of NEURAPAS® balance on current source density (CSD of human EEG

    Directory of Open Access Journals (Sweden)

    Koch Klaus

    2011-08-01

    Full Text Available Abstract Psychiatric patients often suffer from stress, anxiety and depression. Various plant extracts are known to fight stress (valerian, anxiety (passion flower or depression (St. John's wort. NEURAPAS® balance is a mixture of these three extracts and has been designed to cover this complex of psychiatric conditions. The study was initiated to quantitatively assess the effect of this combination on brain electric activity. Method Quantitative electroencephalogram (EEG current source density (CSD recording from 16 healthy male and female human volunteers (average age 49 years was used in a randomized, placebo-controlled cross over study. Recordings were performed 0. 5, 1. 5, 3 and 4 hours after administration of the preparations under the conditions of 6 min eyes open and 5 min d2 concentration test, mathematical calculation test and memory test, respectively. All variables (electric power within 6 frequency ranges at 17 electrode positions were fed into a linear discriminant analysis (eyes open condition. In the presence of mental load these variables were used to construct brain maps of frequency changes. Results Under the condition of mental load, centro-parietal spectral power remained statistically significantly lower within alpha1, alpha2 and beta1 frequencies in the presence of verum in comparison to placebo. Discriminant analysis revealed a difference to placebo 3 and 4 hours after intake of 6 tablets of NEURAPAS® balance. Data location within the polydimensional space was projected into the area of the effects of sedative and anti-depressive reference drugs tested earlier under identical conditions. Results appeared closer to the effects of fluoxetine than to St. John's wort. Conclusions Analysis of the neurophysiological changes following the intake of NEURAPAS® balance revealed a similarity of frequency changes to those of calming and anti-depressive drugs on the EEG without impairment of cognition. Trial registration Clinical

  4. Small firm growth: Organizational structure, human resource planning and the application of Balanced Scorecard: Case Qnware Oy

    OpenAIRE

    Hoang, Hoa

    2015-01-01

    Objectives of the Study: This research was written for the interests of the Case Company - Qnware - a Finnish boutique consultancy looking to scale up via three topics: the application of the Balanced Scorecard, relevant organizational structure and human resource planning. The final deliverables consisted of an actual Balanced Scorecard customized to Qnware, and the list of suggestions regarding the two later topics. Theoretical background and framework: The theories reviewed in...

  5. Impact balance-of-system costs on photovoltaic electric power systems

    Energy Technology Data Exchange (ETDEWEB)

    Saha, H.; Basu, P.; Mukhopadhyay, K.

    1983-03-01

    A simple method based on the balance-of-system (BOS) costs is proposed for computing the allowable solar cell module cost and efficiency for typical applications of photovoltaic electric power systems: microirrigation and a rural electric supply. It is shown that in India the allowable module cost of cell modules with a conversion efficiency of about 5% is about U.S. $2 Wsub(p)/sup -1/ (1980) for microirrigation and about U.S. $0.8 Wsub(p)/sup -1/ for a rural electricity centre. It is further observed that relatively low BOS costs in India and similar places tend to make the allowable module cost become invariant with the efficiency, thus permitting solar cell modules of lower efficiency (5%) to become commercially viable for large-scale applications.

  6. Human resources in innovation systems

    DEFF Research Database (Denmark)

    Nielsen, René Nesgaard

    2007-01-01

    Human resources in innovation systems: With focus on introduction of highly educated labour in small Danish firms This thesis has two purposes: (1) a ‘general' purpose to enhance our knowledge on the relationship between innovation, technological and organisational change, and human resources......, including knowledge and skills embodied in human resources, and (2) a more ‘specific' purpose to enhance our knowledge on introduction of highly educated labour, innovation, and upgrading changes in small Danish firms. Chapter 1 establishes the relevance of this research interest, and it also states...... stemming from human resources - such as insight, understanding, creativity, and action - are inherently important to all innovation processes. The chapter also suggests a tentative conceptual and analytical framework for studying human resources and their development within a system of innovation approach...

  7. Quantitative performance targets by using balanced scorecard system: application to waste management and public administration.

    Science.gov (United States)

    Mendes, Paula; Nunes, Luis Miguel; Teixeira, Margarida Ribau

    2014-09-01

    This article demonstrates how decision-makers can be guided in the process of defining performance target values in the balanced scorecard system. We apply a method based on sensitivity analysis with Monte Carlo simulation to the municipal solid waste management system in Loulé Municipality (Portugal). The method includes two steps: sensitivity analysis of performance indicators to identify those performance indicators with the highest impact on the balanced scorecard model outcomes; and sensitivity analysis of the target values for the previously identified performance indicators. Sensitivity analysis shows that four strategic objectives (IPP1: Comply with the national waste strategy; IPP4: Reduce nonrenewable resources and greenhouse gases; IPP5: Optimize the life-cycle of waste; and FP1: Meet and optimize the budget) alone contribute 99.7% of the variability in overall balanced scorecard value. Thus, these strategic objectives had a much stronger impact on the estimated balanced scorecard outcome than did others, with the IPP1 and the IPP4 accounting for over 55% and 22% of the variance in overall balanced scorecard value, respectively. The remaining performance indicators contribute only marginally. In addition, a change in the value of a single indicator's target value made the overall balanced scorecard value change by as much as 18%. This may lead to involuntarily biased decisions by organizations regarding performance target-setting, if not prevented with the help of methods such as that proposed and applied in this study.

  8. Impact and Estimation of Balance Coordinate System Rotations and Translations in Wind-Tunnel Testing

    Science.gov (United States)

    Toro, Kenneth G.; Parker, Peter A.

    2017-01-01

    Discrepancies between the model and balance coordinate systems lead to biases in the aerodynamic measurements during wind-tunnel testing. The reference coordinate system relative to the calibration coordinate system at which the forces and moments are resolved is crucial to the overall accuracy of force measurements. This paper discusses sources of discrepancies and estimates of coordinate system rotation and translation due to machining and assembly differences. A methodology for numerically estimating the coordinate system biases will be discussed and developed. Two case studies are presented using this methodology to estimate the model alignment. Examples span from angle measurement system shifts on the calibration system to discrepancies in actual wind-tunnel data. The results from these case-studies will help aerodynamic researchers and force balance engineers to better the understand and identify potential differences in calibration systems due to coordinate system rotation and translation.

  9. Human Balance out of Equilibrium: Nonequilibrium Statistical Mechanics in Posture Control

    Science.gov (United States)

    Lauk, Michael; Chow, Carson C.; Pavlik, Ann E.; Collins, James J.

    1998-01-01

    During quiet standing, the human body sways in a stochastic manner. Here we show that the fluctuation-dissipation theorem can be applied to the human postural control system. That is, the dynamic response of the postural system to a weak mechanical perturbation can be predicted from the fluctuations exhibited by the system under quasistatic conditions. We also show that the estimated correlation and response functions can be described by a simple stochastic model consisting of a pinned polymer. These findings suggest that the postural control system utilizes the same control mechanisms under quiet-standing and dynamic conditions.

  10. Energy balance for steam generation system with biomass dryer

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Pedro A.R. [Instituto Superior Politecnico Jose Antonio Echeverria (CUJAE), Ciudad de La Habana (Cuba). Facultad Ingenieria Mecanica]. E-mail: pedro@economia.cujae.edu.cu; Lombardi, Geraldo; Santos, Antonio Moreira dos [Universidade de Sao Paulo (USP), Sao Carlos, SP (Brazil). Escola de Engenharia]. E-mails: lombardi@sc.usp.br; asantos@sc.usp.br

    2008-07-01

    Water content is a major drainer of the energy available in the biomass, which justifies the proposal of a drying system with the potential to increase 80% of the biomass low heating value, also increasing the production of steam in the boiler and cogeneration of electricity. An example of biomass is the sugar cane bagasse of an alcohol mill producing 120,000 liters of alcohol per day, whose humidity from the extraction section is usually 50%. The present paper determines the increases in the mass flow rates of steam in the boiler, in the cogeneration of electricity and in the pay back time of the drying system and of the alcohol mill, as a consequence of the bagasse drying from 50 to 35%, considering 30% of air excess over the stoichiometric value admitted in the boiler for the bagasse burning. It also provides subsidies for the development and deployment of a drying system for the current boilers. (author)

  11. Modeling the basin of attraction as a two-dimensional manifold from experimental data: applications to balance in humans.

    Science.gov (United States)

    Zakynthinaki, Maria S; Stirling, James R; Martínez, Carlos A Cordente; de Durana, Alfonso López Díaz; Quintana, Manuel Sillero; Romo, Gabriel Rodríguez; Molinuevo, Javier Sampedro

    2010-03-01

    We present a method of modeling the basin of attraction as a three-dimensional function describing a two-dimensional manifold on which the dynamics of the system evolves from experimental time series data. Our method is based on the density of the data set and uses numerical optimization and data modeling tools. We also show how to obtain analytic curves that describe both the contours and the boundary of the basin. Our method is applied to the problem of regaining balance after perturbation from quiet vertical stance using data of an elite athlete. Our method goes beyond the statistical description of the experimental data, providing a function that describes the shape of the basin of attraction. To test its robustness, our method has also been applied to two different data sets of a second subject and no significant differences were found between the contours of the calculated basin of attraction for the different data sets. The proposed method has many uses in a wide variety of areas, not just human balance for which there are many applications in medicine, rehabilitation, and sport.

  12. Prebiotic Effects of Xylooligosaccharides on the Improvement of Microbiota Balance in Human Subjects

    Directory of Open Access Journals (Sweden)

    Shyh-Hsiang Lin

    2016-01-01

    Full Text Available It has been indicated that probiotics can be nourished by consuming prebiotics in order to function more efficiently, allowing the bacteria to stay within a healthy balance. In this study, we investigated the effects of xylooligosaccharides- (XOS- enriched rice porridge consumption on the ecosystem in the intestinal tract of human subjects. Twenty healthy subjects participated in this 6-week trial, in which 10 subjects received XOS-enriched rice porridge while the others received placebo rice porridge. Fecal samples were collected at the end of weeks 0, 1, 3, 4, 6, and 7 for microorganism examination. The results showed that 6-week daily ingestion of the XOS-enriched rice porridge induced significant increases in fecal bacterial counts of Lactobacillus spp. and Bifidobacterium spp., as well as decreases in Clostridium perfringens without changing the total anaerobic bacterial counts, compared to that of placebo rice porridge. However, fluctuations in the counts of coliforms were observed in both groups during the 6-week intervention. In conclusion, the intestinal microbiota balance was improved after daily consumption of 150 g of rice porridge containing XOS for 6 weeks, demonstrating the prebiotic potential of XOS incorporated into foods. This also indicates the effectiveness of XOS as a functional ingredient in relation to its role as a prebiotic compound.

  13. Prebiotic Effects of Xylooligosaccharides on the Improvement of Microbiota Balance in Human Subjects.

    Science.gov (United States)

    Lin, Shyh-Hsiang; Chou, Liang-Mao; Chien, Yi-Wen; Chang, Jung-Su; Lin, Ching-I

    2016-01-01

    It has been indicated that probiotics can be nourished by consuming prebiotics in order to function more efficiently, allowing the bacteria to stay within a healthy balance. In this study, we investigated the effects of xylooligosaccharides- (XOS-) enriched rice porridge consumption on the ecosystem in the intestinal tract of human subjects. Twenty healthy subjects participated in this 6-week trial, in which 10 subjects received XOS-enriched rice porridge while the others received placebo rice porridge. Fecal samples were collected at the end of weeks 0, 1, 3, 4, 6, and 7 for microorganism examination. The results showed that 6-week daily ingestion of the XOS-enriched rice porridge induced significant increases in fecal bacterial counts of Lactobacillus spp. and Bifidobacterium spp., as well as decreases in Clostridium perfringens without changing the total anaerobic bacterial counts, compared to that of placebo rice porridge. However, fluctuations in the counts of coliforms were observed in both groups during the 6-week intervention. In conclusion, the intestinal microbiota balance was improved after daily consumption of 150 g of rice porridge containing XOS for 6 weeks, demonstrating the prebiotic potential of XOS incorporated into foods. This also indicates the effectiveness of XOS as a functional ingredient in relation to its role as a prebiotic compound.

  14. Human resources in innovation systems

    DEFF Research Database (Denmark)

    Nielsen, René Nesgaard

    2007-01-01

    the research questions which are studied in the thesis.      Chapter 2 reviews relevant literature on systems of innovation, human capital, and skill-biased technological and organisational change. It is stated in the chapter that this thesis primarily refers to a system of innovation approach as its......Human resources in innovation systems: With focus on introduction of highly educated labour in small Danish firms This thesis has two purposes: (1) a ‘general' purpose to enhance our knowledge on the relationship between innovation, technological and organisational change, and human resources......, including knowledge and skills embodied in human resources, and (2) a more ‘specific' purpose to enhance our knowledge on introduction of highly educated labour, innovation, and upgrading changes in small Danish firms. Chapter 1 establishes the relevance of this research interest, and it also states...

  15. The Dutch corporate governance code and its monitoring: a balanced system?

    NARCIS (Netherlands)

    Hof, B.; Kerste, M.; Rosenboom, N.; Rougoor, W.; de Jong, A.

    2013-01-01

    The compliance of exchange-listed companies with the Dutch corporate governance code is generally high. This research takes three hypothetical changes to the current system as a starting point to investigate the question: is the Dutch system of regulating and monitoring corporate governance balanced

  16. Not as Easy as It Sounds: Designing a Balanced Assessment System

    Science.gov (United States)

    Chattergoon, Rajendra; Marion, Scott

    2016-01-01

    Many states and school districts are rethinking how they do educational assessment. A few are going further: attempting to build "balanced," "comprehensive," or "next-generation" assessment systems. At the same time, practitioners and researchers have long mulled the purposes and parts such systems should have. But…

  17. An energy-balancing perspective of interconnection and damping assignment control of nonlinear systems

    NARCIS (Netherlands)

    Jeltsema, Dimitri; Ortega, Romeo; Scherpen, Jacquelien M.A.

    2004-01-01

    Stabilization of nonlinear feedback passive systems is achieved assigning a storage function with a minimum at the desired equilibrium. For physical systems a natural candidate storage function is the difference between the stored and the supplied energies—leading to the so-called energy-balancing c

  18. Energy management based on AM/FM/GIS for phase balancing application on distribution systems

    Energy Technology Data Exchange (ETDEWEB)

    Kuo, C.-C., E-mail: cckuo@mail.sju.edu.t [Department of Electrical Engineering, Saint John' s University, 499, Sec. 4, TamKing Rd., Taipei, TamSui 25135, Taiwan (China); Chao, Y.-T., E-mail: bv2cr@yahoo.com.t [Department of Information Management, Technology and Science Institute of Northern Taiwan, 2, Xueyuan Rd., Peitou, Taipei 112, Taiwan (China)

    2010-03-15

    Unbalanced feeder systems may deteriorate of power quality, and increase investment and operating costs for distribution systems. The phase swapping method recommends re-phasing circuits of laterals and transformers for making the current and voltage balanced and also reducing feeder loss and voltage drop. In this paper, an application program, based on the automated mapping/facilities management/ geographic information system (AM/FM/GIS) is developed which contains a function of automatically computing Z-bus, load flow and phase balancing of feeders with phase swapping by using easily selecting of feeder on a graphic user interface application. Therefore, the relative data need not be keyed in manually. The presented phase balancing algorithm are based on database and related data structures developed on the AM/FM/GIS and Visual Basic software, which can be integrated into the Tai-Power distribution automation system. Then, the phase balancing algorithm is designed to handle the load patterns and the load of transformers that connect specific feeders when evaluating phase swaps that will result in reduced daily circuit losses over all load points. The proposed application not only can effectively reduce the circuit loss and improves phase balancing, but also enhances power quality efficiently under easily using environment.

  19. Interactive rehabilitation system for improvement of balance therapies in people with cerebral palsy.

    Science.gov (United States)

    Jaume-i-Capó, Antoni; Martínez-Bueso, Pau; Moyà-Alcover, Biel; Varona, Javier

    2014-03-01

    The present study covers a new experimental system, designed to improve the balance and postural control of adults with cerebral palsy. This system is based on a serious game for balance rehabilitation therapy, designed using the prototype development paradigm and features for rehabilitation with serious games: feedback, adaptability, motivational elements, and monitoring. In addition, the employed interaction technology is based on computer vision because motor rehabilitation consists of body movements that can be recorded, and because vision capture technology is noninvasive and can be used for clients who have difficulties in holding physical devices. Previous research has indicated that serious games help to motivate clients in therapy sessions; however, there remains a paucity of clinical evidence involving functionality. We rigorously evaluated the effects of physiotherapy treatment on balance and gait function of adult subjects with cerebral palsy undergoing our experimental system. A 24-week physiotherapy intervention program was conducted with nine adults from a cerebral palsy center who exercised weekly in 20-min sessions. Findings demonstrated a significant increase in balance and gait function scores resulting in indicators of greater independence for our participating adults. Scores improved from 16 to 21 points in a scale of 28, according to the Tinetti Scale for risk of falls, moving from high fall risk to moderate fall risk. Our promising results indicate that our experimental system is feasible for balance rehabilitation therapy.

  20. The functional assessment Berg Balance Scale is better capable of estimating fall risk in the elderly than the posturographic Balance Stability System.

    Science.gov (United States)

    Pereira, Vanessa Vieira; Maia, Roberto Alcantara; Silva, Sonia Maria Cesar de Azevedo

    2013-01-01

    The purpose of this study was to verify which instrument better identifies recurrent falls in the elderly. Ninety-eight old people, with an average age of 80 ± 4 years, were submitted to an assessment of balance and fall risk by means of the Berg Balance Scale (BBS) and the posturographic Balance Stability System (BSS). The BBS was correlated with the BSS (r=-0.27; p=0.008), age (r=-0.38; pbalance and demonstrated a greater capacity to identify falls risk suffered over the last year when compared with the BSS.

  1. Minimizing and balancing setups in a serial production system

    OpenAIRE

    Detti, Paolo; Pranzo, Marco; Meloni, Carlo

    2007-01-01

    Abstract This paper addresses a problem arising in the coordination between two consecutive manufacturing departments of a production system, in which parts are processed in batches, and each batch is characterized by two distinct attributes. Due to limited interstage buffering between the two stages, the two departments have to follow the same batch sequence. In the first department, a setup occurs every time the first attribute of the new batch is different f...

  2. Steam System Balancing and Tuning for Multifamily Residential Buildings in Chicagoland

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jayne [Partnership for Advanced Residential Retrofit (PARR), Chicago, IL (United States); Ludwig, Peter [Partnership for Advanced Residential Retrofit (PARR), Chicago, IL (United States); Brand, Larry [Partnership for Advanced Residential Retrofit (PARR), Chicago, IL (United States)

    2012-08-01

    Older heating systems often suffer from mis-investment--multiple contractors upgrading parts of systems in inadequate or inappropriate ways that reduce system functionality and efficiency--or from a lack of proper maintenance. This technical report addresses these barriers to information, contractor resources, and cost-savings. Building off of previous research, CNT Energy conducted a study to identify best practices for the methodology, typical costs, and energy savings associated with steam system balancing.

  3. Asymmetry-aware load balancing for parallel applications in single-ISA multi-core systems

    Institute of Scientific and Technical Information of China (English)

    EunsungKIM; Hyeonsang EOM; Heon Y. YEOM

    2012-01-01

    Contemporary operating systems for single-ISA (instruction set architecture) multi-core systems attempt to distribute tasks equally among all the CPUs.This approach works relatively well when there is no difference in CPU capability.However,there are cases in which CPU capability differs from one another.For instance,static capability asymmetry results from the advent of new asymmetric hardware,and dynamic capability asymmetry comes from the operating system (OS) outside noise caused from networking or I/O handling.These asymmetries can make it hard for the OS scheduler to evenly distribute the tasks,resulting in less efficient load balancing.In this paper,we propose a user-level load balancer for parallel applications,called the ‘capability balancer',which recognizes the difference of CPU capability and makes subtasks share the entire CPU capability fairly.The balancer can coexist with the existing kernel-level load balancer without detrimenting the behavior of the kernel balancer.The capability balancer can fairly distribute CPU capability to tasks with very little overhead.For real workloads like the NAS Parallel Benchmark (NPB),we have accomplished speedups of up to 9.8% and 8.5% in dynamic and static asymmetries,respectively.We have also experienced speedups of 13.3 % for dynamic asymmetry and 24.1% for static asymmetry in a competitive environment.The impacts of our task selection policies,FIFO (first in,first out) and cache,were compared.The use of the cache policy led to a speedup of 5.3% in overall execution time and a decrease of 4.7% in the overall cache miss count,compared with the FIFO policy,which is used by default.

  4. Numerical Estimation of Balanced and Falling States for Constrained Legged Systems

    Science.gov (United States)

    Mummolo, Carlotta; Mangialardi, Luigi; Kim, Joo H.

    2017-08-01

    Instability and risk of fall during standing and walking are common challenges for biped robots. While existing criteria from state-space dynamical systems approach or ground reference points are useful in some applications, complete system models and constraints have not been taken into account for prediction and indication of fall for general legged robots. In this study, a general numerical framework that estimates the balanced and falling states of legged systems is introduced. The overall approach is based on the integration of joint-space and Cartesian-space dynamics of a legged system model. The full-body constrained joint-space dynamics includes the contact forces and moments term due to current foot (or feet) support and another term due to altered contact configuration. According to the refined notions of balanced, falling, and fallen, the system parameters, physical constraints, and initial/final/boundary conditions for balancing are incorporated into constrained nonlinear optimization problems to solve for the velocity extrema (representing the maximum perturbation allowed to maintain balance without changing contacts) in the Cartesian space at each center-of-mass (COM) position within its workspace. The iterative algorithm constructs the stability boundary as a COM state-space partition between balanced and falling states. Inclusion in the resulting six-dimensional manifold is a necessary condition for a state of the given system to be balanced under the given contact configuration, while exclusion is a sufficient condition for falling. The framework is used to analyze the balance stability of example systems with various degrees of complexities. The manifold for a 1-degree-of-freedom (DOF) legged system is consistent with the experimental and simulation results in the existing studies for specific controller designs. The results for a 2-DOF system demonstrate the dependency of the COM state-space partition upon joint-space configuration (elbow-up vs

  5. Numerical Estimation of Balanced and Falling States for Constrained Legged Systems

    Science.gov (United States)

    Mummolo, Carlotta; Mangialardi, Luigi; Kim, Joo H.

    2017-01-01

    Instability and risk of fall during standing and walking are common challenges for biped robots. While existing criteria from state-space dynamical systems approach or ground reference points are useful in some applications, complete system models and constraints have not been taken into account for prediction and indication of fall for general legged robots. In this study, a general numerical framework that estimates the balanced and falling states of legged systems is introduced. The overall approach is based on the integration of joint-space and Cartesian-space dynamics of a legged system model. The full-body constrained joint-space dynamics includes the contact forces and moments term due to current foot (or feet) support and another term due to altered contact configuration. According to the refined notions of balanced, falling, and fallen, the system parameters, physical constraints, and initial/final/boundary conditions for balancing are incorporated into constrained nonlinear optimization problems to solve for the velocity extrema (representing the maximum perturbation allowed to maintain balance without changing contacts) in the Cartesian space at each center-of-mass (COM) position within its workspace. The iterative algorithm constructs the stability boundary as a COM state-space partition between balanced and falling states. Inclusion in the resulting six-dimensional manifold is a necessary condition for a state of the given system to be balanced under the given contact configuration, while exclusion is a sufficient condition for falling. The framework is used to analyze the balance stability of example systems with various degrees of complexities. The manifold for a 1-degree-of-freedom (DOF) legged system is consistent with the experimental and simulation results in the existing studies for specific controller designs. The results for a 2-DOF system demonstrate the dependency of the COM state-space partition upon joint-space configuration (elbow-up vs

  6. Dynamic balancing of dual-rotor system with very little rotating speed difference

    Institute of Scientific and Technical Information of China (English)

    杨健; 贺世正; 王乐勤

    2003-01-01

    Unbalanced vibration in dual-rotor rotating machinery was studied with numerical simulations and experiments. A new method is proposed to separate vibration signals of inner and outer rotors for a system with very little difference in rotating speeds. Magnitudes and phase values of unbalance defects can be obtained directly by sampling the vibration signal synchronized with reference signal. The balancing process is completed by the reciprocity influence coefficients of inner and outer rotors method. Results showed the advantage of such method for a dual-rotor system as compared with conventional balancing.

  7. Optimal reconfiguration and DG allocation in balanced and unbalanced distribution systems

    Directory of Open Access Journals (Sweden)

    Seyed Abbas Taher

    2014-09-01

    Full Text Available This paper investigates feeder reconfiguration in balanced and unbalanced networks and presents an efficient method to optimize practical distribution systems by means of simultaneous reconfiguration and distributed generation (DG allocation. A precise and robust load flow algorithm is applied and a composite multi-objective function is formulated to solve the problem which includes: 1. power loss saving, 2. voltage profile, 3. voltage unbalance, and 4. current unbalance of the system. The genetic algorithm (GA is utilized to search for optimal solution. Results show significant reduction in power loss and number of voltage violations. Moreover, in unbalanced cases, ability of proposed method in three-phase balancing is demonstrated.

  8. Load-Balance Policy in Two Level-Cluster File System

    Institute of Scientific and Technical Information of China (English)

    LIU Yuling; SONG Weiwei; MA Xiaoxue

    2006-01-01

    In this paper, we explored a load-balancing algorithm in a cluster file system contains two levels of metadata-server,primary-level server quickly distributestasks to second-level servers depending on the closest load-balancing information. At the same time, we explored a method which accurately reflect I/O traffic and storage of storage-node: computing the heat-value of file, according to which we realized a more logical storage allocation. According to the experiment result, we conclude that this new algorithm shortens the executing time of tasks and improves the system performance compared with other load algorithm.

  9. Balancing Multiple Objectives Using a Classification-Based Forest Management System in Changbai Mountains, China

    Science.gov (United States)

    Zhao, Fuqiang; Yang, Jian; Liu, Zhihua; Dai, Limin; He, Hong S.

    2011-12-01

    Contemporary forest management often consists of multiple objectives, including restoration of human-impacted forested landscapes toward their range of natural variability (RNV) and sustainable levels of timber production. Balancing multiple management objectives is often challenging due to intrinsic conflicts between these objectives and a lack of reference conditions for evaluating the effectiveness of forest restoration efforts. We used a spatially explicit forest landscape model to assess how well a classification-based forest management (CFM) system could achieve multiple objectives in a Korean pine broadleaf mixed forest ecosystem at Changbai Mountain in Northeast China. The CFM system divided the forest landscape into three management areas (Commercial Forest, Special Ecological Welfare Forest, and General Ecological Welfare Forest), each with its own management objectives and prescriptions, but with an overall goal of increasing the ecological and economic sustainability of the entire landscape. The zoning approach adopted in the Chinese CFM system is very similar to the TRIAD approach that is being advocated for managing public forests in Canada. In this study, a natural disturbance scenario and seven harvest scenarios (one identical to the current harvest regime and six alternative scenarios) were simulated to examine how tree species composition, age structure, and timber production at the landscape level can be affected by different strategies under the CFM system. The results indicated that the current forest management regime would not only fail to reach the designated timber production level but also move the forest landscape far away from its RNV. In order to return the currently altered forest landscape to approach its RNV while providing a stable level of timber production over time, harvest intensities should be reduced to a level that is equivalent to the amount of timber removals that would occur under the natural disturbances; and the

  10. Effects of balance training using a virtual-reality system in older fallers

    Directory of Open Access Journals (Sweden)

    Duque G

    2013-02-01

    Full Text Available Gustavo Duque,1,2 Derek Boersma,1 Griselda Loza-Diaz,2 Sanobar Hassan,1 Hamlet Suarez,3 Dario Geisinger,3 Pushpa Suriyaarachchi,1 Anita Sharma,1 Oddom Demontiero1,21Falls and Fractures Clinic, Department of Geriatric Medicine, Nepean Hospital, Penrith, NSW, Australia; 2Ageing Bone Research Program, Division of Geriatric Medicine, Sydney Medical School Nepean, The University of Sydney, Penrith, NSW, Australia; 3British Hospital, CLAEH School of Medicine, Montevideo, UruguayAbstract: Poor balance is considered a challenging risk factor for falls in older adults. Therefore, innovative interventions for balance improvement in this population are greatly needed. The aim of this study was to evaluate the effect of a new virtual-reality system (the Balance Rehabilitation Unit [BRU] on balance, falls, and fear of falling in a population of community-dwelling older subjects with a known history of falls. In this study, 60 community-dwelling older subjects were recruited after being diagnosed with poor balance at the Falls and Fractures Clinic, Nepean Hospital (Penrith, NSW, Australia. Subjects were randomly assigned to either the BRU-training or control groups. Both groups received the usual falls prevention care. The BRU-training group attended balance training (two sessions/week for 6 weeks using an established protocol. Change in balance parameters was assessed in the BRU-training group at the end of their 6-week training program. Both groups were assessed 9 months after their initial assessment (month 0. Adherence to the BRU-training program was 97%. Balance parameters were significantly improved in the BRU-training group (P < 0.01. This effect was also associated with a significant reduction in falls and lower levels of fear of falling (P < 0.01. Some components of balance that were improved by BRU training showed a decline after 9 months post-training. In conclusion, BRU training is an effective and well-accepted intervention to improve balance

  11. Effects of high heeled shoes wearing experience and heel height on human standing balance and functional mobility.

    Science.gov (United States)

    Hapsari, Vaniessa Dewi; Xiong, Shuping

    2016-01-01

    This study aimed to examine the effects of high heeled shoes (HHS) wearing experience and heel height on human standing balance and functional mobility. Thirty young and healthy females (ten experienced and twenty inexperienced HHS wearers) participated in a series of balance tests when they wore shoes of four different heel heights: 1 cm (flat), 4 cm (low), 7 cm (medium) and 10 cm (high). Experimental results show that regardless of the wearing experience, the heel elevation induces more effort from lower limb muscles (particularly calf muscles) and results in worse functional mobility starting at 7 cm heel height. While the heel height increased to 10 cm, the standing balance also becomes worse. Experienced HHS wearers do not show significantly better overall performance on standing balance and functional mobility than inexperienced controls, even though they have better directional control (76.8% vs. 74.4%) and larger maximum excursion (93.3% vs. 89.7%). To maintain standing balance, experienced wearers exert less effort on tibialis anterior, vastus lateralis and erector spinae muscles at the cost of more intensive effort from gastrocnemius medialis muscle. Many women wear high heeled shoes (HHS) to increase female attractiveness. This study shows that HHS induce more muscular effort and worse human standing balance and functional mobility, especially when heel height reaches 10 cm. HHS wearing experience only provides certain advantages to wearers on limits of stability in terms of larger maximum excursion and better directional control.

  12. Characterization of human manure-derived biochar and energy-balance analysis of slow pyrolysis process.

    Science.gov (United States)

    Liu, Xuan; Li, Zifu; Zhang, Yaozhong; Feng, Rui; Mahmood, Ibrahim Babatunde

    2014-09-01

    Biochars have received increasing attention in recent years because of their soil improvement potential, contaminant immobilization properties, and ability to function as carbon sinks. This study adopted a pyrolytic process to prepare a series of biochars from dried human manure at varying temperatures. The thermal analysis of human manure and physicochemical properties of the resulting biochars illustrated that human manure can be a favorable feedstock for biochar production. In particular, the porous texture and nutrient-rich properties of biochars produced from human manure and may significantly enhance soil fertility when used as used soil additives. A temperature range of 500-600°C was optimal for human manure biochar production. Significantly, when the moisture content of the feedstock is lower than 57%, the system could not only harvest manure-derived biochar but also have a net energy output, which can be provide heat source for nearby users.

  13. Examining human-system interactions: The HSYS (Human SYStem) methodology

    Energy Technology Data Exchange (ETDEWEB)

    Hill, S.G.; Harbour, J.L.; Sullivan, C.; Hallbert, B.P. (Idaho National Engineering Lab., Idaho Falls, ID (USA))

    1990-01-01

    HSYS is a model-based methodology developed to examine the many factors which influence Human-SYStem interactions. HSYS is built around a linear model of human performance, called the Input-Action model, which describes five sequential steps: Input Detection, Input Understanding, Action Selection, Action Planning, and Action Execution. HSYS is structured in an hierarchical tree which presents a logical structure for examining potential areas where human performance, hardware or other system components are less than adequate. The HSYS tree consists of five major branches which correspond to the five major components of the Input-Action model. Initial validation was begun by studying accident reports via HSYS and identifying sources of error. The validation process has continued with accident investigations in operational settings. 9 refs., 3 figs.

  14. The effect on human balance of standing with toe-extension.

    Directory of Open Access Journals (Sweden)

    Pei Xuan Ku

    Full Text Available BACKGROUND: Postural balance is vital for safely carrying out many daily activities, such as locomotion. The purpose of this study was to determine how changes in normal standing (NS and standing with toe-extension (SWT impact postural control during quiet standing. Furthermore, the research aimed to examine the extent to which the effect of these factors differed between genders. METHODOLOGY/PRINCIPAL FINDINGS: Thirty healthy young adults (age = 21.2±1.3 y; height = 1.63±0.07 m; mass = 56.0±9.3 kg with no prior lower limb injuries participated in the study. A postural stability test using the Biodex Balance System was used for both NS and SWT conditions. The three measurements from the BBS were Overall Stability Index (OSI, Medial-Lateral Stability Index (MLSI and Anterior-Posterior Stability Index (APSI. No significant difference was found between NS and SWT in the OSI, MLSI or APSI (F(2, 28 = 3.357, p = 0.077. The main difference between the stability index scores was significant (F(2, 28 = 275.1, p<0.001. The Bonferroni post-hoc test showed significant differences between the OSI and MLSI (p<0.001; the OSI and APSI (p<0.001; and the MLSI and the APSI (p<0.001. Significant differences were found during NS (p<0.001, for the MLSI when compared with the APSI, but this was not found during the SWT condition. Additionally, no gender effects were proven to exist that altered postural sway during quiet standing. CONCLUSIONS/SIGNIFICANCE: This study reveals significant interaction between the stability indices measured; OSI, APSI and MLSI in both NS and SWT. Standing with toe extended does not have a significant impact on an individual's ability to control their balance during normal quiet standing. However, the findings revealed that the sway tendency in the medial-lateral direction might serve as a factor in an individual's ability to regain balance.

  15. Measure Guideline. Steam System Balancing and Tuning for Multifamily Residential Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jayne [Partnership for Advanced Residential Retrofit (PARR), Chicago, IL (United States); Ludwig, Peter [Partnership for Advanced Residential Retrofit (PARR), Chicago, IL (United States); Brand, Larry [Partnership for Advanced Residential Retrofit (PARR), Chicago, IL (United States)

    2013-04-01

    This guideline provides building owners, professionals involved in multifamily audits, and contractors insights for improving the balance and tuning of steam systems. It provides readers an overview of one-pipe steam heating systems, guidelines for evaluating steam systems, typical costs and savings, and guidelines for ensuring quality installations. It also directs readers to additional resources for details not included here. Measures for balancing a distribution system that are covered include replacing main line vents and upgrading radiator vents. Also included is a discussion on upgrading boiler controls and the importance of tuning the settings on new or existing boiler controls. The guideline focuses on one-pipe steam systems, though many of the assessment methods can be generalized to two-pipe steam systems.

  16. HYDRODYNAMICALLY BALANCED SYSTEMS (HBS: INNOVATIVE APPROACH OF GASTRO RETENTION: A REVIEW

    Directory of Open Access Journals (Sweden)

    Dubey Vivek

    2012-06-01

    Full Text Available The objective of writing this review on hydrodynamically balanced systems (HBS was collection of the recent literature. The design of hydrodynamically balanced drug delivery system is base on prolong GI residence time of drug in an area of the GI tract to maximize drug reaching its absorption. Gastrointestinal transit time of orally administered dosage forms are controlled by using gastro retentive drug delivery systems (GRDDS. Need for GRDDS a controlled drug delivery system with prolonged residence time in the stomach. Floating drug delivery systems is one of the important approaches to achieve gastric retention to obtain sufficient drug bioavailability. This delivery system is desirable for drugs with an absorption window in the stomach or in the upper small intestine.

  17. Reliability of the good balance system(®) for postural sway measurement in poststroke patients.

    Science.gov (United States)

    Ha, Hyungeun; Cho, Kihun; Lee, Wanhee

    2014-01-01

    [Purpose] The purpose of this study was to examine test-retest reliability of the Good Balance system(®) for measurement of postural sway in poststroke patients. [Subjects] Sixty chronic stroke patients (40 men and 20 women; age 63.08 years; stroke duration 16.45 months) participated in this study. [Methods] Postural sway was evaluated using a force platform system (Good Balance system, Metitur Oy, Jyvaskyla, Finland). Two examiners measured postural sway for all participants during two separate testing sessions. The second measurement was performed one week after the first measurement. Intraclass correlation coefficients [ICC(2,1)] were used for estimation of reliability. [Results] The ICC (95% CI) for intra-examiner reliability was good to very good, ranging from 0.69 to 0.93 (0.53-0.96), and the ICC for inter-examiner reliability was good to very good, ranging from 0.85 to 0.98 (0.77-0.99). [Conclusion] The results of the current study indicated that the intra- and inter-examiner reliability of the Good Balance system(®) for measurement of postural sway was good to very good. Therefore, we suggest that measurement of postural sway using the Good Balance system(®) would be useful for clinical assessment in poststroke patients.

  18. An equivalent unbalance identification method for the balancing of nonlinear squeeze-film damped rotordynamic systems

    Science.gov (United States)

    Torres Cedillo, Sergio G.; Bonello, Philip

    2016-01-01

    The high pressure (HP) rotor in an aero-engine assembly cannot be accessed under operational conditions because of the restricted space for instrumentation and high temperatures. This motivates the development of a non-invasive inverse problem approach for unbalance identification and balancing, requiring prior knowledge of the structure. Most such methods in the literature necessitate linear bearing models, making them unsuitable for aero-engine applications which use nonlinear squeeze-film damper (SFD) bearings. A previously proposed inverse method for nonlinear rotating systems was highly limited in its application (e.g. assumed circular centered SFD orbits). The methodology proposed in this paper overcomes such limitations. It uses the Receptance Harmonic Balance Method (RHBM) to generate the backward operator using measurements of the vibration at the engine casing, provided there is at least one linear connection between rotor and casing, apart from the nonlinear connections. A least-squares solution yields the equivalent unbalance distribution in prescribed planes of the rotor, which is consequently used to balance it. The method is validated on distinct rotordynamic systems using simulated casing vibration readings. The method is shown to provide effective balancing under hitherto unconsidered practical conditions. The repeatability of the method, as well as its robustness to noise, model uncertainty and balancing errors, are satisfactorily demonstrated and the limitations of the process discussed.

  19. Mass-balance Approach to Interpreting Weathering Reactions in Watershed Systems

    Science.gov (United States)

    Bricker, O. P.; Jones, B. F.; Bowser, C. J.

    2003-12-01

    The mass-balance approach is conceptually simple and has found widespread applications in many fields over the years. For example, chemists use mass balance (Stumm and Morgan, 1996) to sum the various species containing an element in order to determine the total amount of that element in the system (free ion, complexes). Glaciologists use mass balance to determine the changes in mass of glaciers ( Mayo et al., 1972 and references therein). Groundwater hydrologists use this method to interpret changes in water balance in groundwater systems ( Rasmussen and Andreasen, 1959; Bredehoeft et al., 1982; Heath, 1983; Konikow and Mercer, 1988; Freeze and Cherry, 1979; Ingebritsen and Sanford, 1998). This method has also been used to determine changes in chemistry along a flow path ( Plummer et al., 1983; Bowser and Jones, 1990) and to quantify lake hydrologic budgets using stable isotopes ( Krabbenhoft et al., 1994). Blum and Erel (see Chapter 5.12) discuss the use of strontium isotopes, Chapelle (see Chapter 5.14) treats carbon isotopes in groundwater, and Kendall and Doctor (see Chapter 5.11) and Kendall and McDonnell (1998) discuss the use of stable isotopes in mass balance. Although the method is conceptually simple, the parameters that define a mass balance are not always easy to measure. Watershed investigators use mass balance to determine physical and chemical changes in watersheds ( Garrels and Mackenzie, 1967; Plummer et al., 1991; O'Brien et al., 1997; Drever, 1997). Here we focus on describing the mass-balance approach to interpret weathering reactions in watershed systems including shallow groundwater.Because mass balance is simply an accounting of the flux of material into a system minus the flux of material out of the system, the geochemical mass-balance approach is well suited to interpreting weathering reactions in watersheds (catchments) and in other environmental settings (Drever, 1997). It is, perhaps, the most accurate and reliable way of defining

  20. Work-life Balance Decision-making of Norwegian Students: Implications for Human Resources Management

    Directory of Open Access Journals (Sweden)

    Remigiusz Gawlik

    2016-12-01

    Full Text Available Objective: The paper aims at identifying and assessing the significance of work-life balance determinants between the Youth of highly developed societies and its implications for human resources management on the example of Norway. Research Design & Methods: The research target group consists of 236 respondents recruited among Norwegian tertiary education students. It employed literature analysis, two-stage exploratory research: direct individual in-depth interviews, survey based on a self-administered, web-based questionnaire with single-answer, limited choice qualitative & quantitative, as well as explanatory research (informal moderated group discussions. Findings: The research on perceptions of determinants of quality of life and attractiveness of life strategies shows that in a country with relatively high socio-economic development level, such as Norway, differences in rankings do exist. They can be observed in relevance to both material and non-material QoL determinants. Implications & Recommendations: The study revealed a need for deeper research on individually driven early decision-making of future employees and entrepreneurs. This will result in closer modelling of socio-economic phenomena, including more accurate adaptation to trends on the labour market and creation of new business models. Contribution & Value Added: Research value added comes from the comparison of perceptions of quality of life determinants between countries at various stages of socio-economic development and its implications for human resource management.

  1. Reliability of System Identification Techniques to Assess Standing Balance in Healthy Elderly.

    Directory of Open Access Journals (Sweden)

    Jantsje H Pasma

    Full Text Available System identification techniques have the potential to assess the contribution of the underlying systems involved in standing balance by applying well-known disturbances. We investigated the reliability of standing balance parameters obtained with multivariate closed loop system identification techniques.In twelve healthy elderly balance tests were performed twice a day during three days. Body sway was measured during two minutes of standing with eyes closed and the Balance test Room (BalRoom was used to apply four disturbances simultaneously: two sensory disturbances, to the proprioceptive and the visual system, and two mechanical disturbances applied at the leg and trunk segment. Using system identification techniques, sensitivity functions of the sensory disturbances and the neuromuscular controller were estimated. Based on the generalizability theory (G theory, systematic errors and sources of variability were assessed using linear mixed models and reliability was assessed by computing indexes of dependability (ID, standard error of measurement (SEM and minimal detectable change (MDC.A systematic error was found between the first and second trial in the sensitivity functions. No systematic error was found in the neuromuscular controller and body sway. The reliability of 15 of 25 parameters and body sway were moderate to excellent when the results of two trials on three days were averaged. To reach an excellent reliability on one day in 7 out of 25 parameters, it was predicted that at least seven trials must be averaged.This study shows that system identification techniques are a promising method to assess the underlying systems involved in standing balance in elderly. However, most of the parameters do not appear to be reliable unless a large number of trials are collected across multiple days. To reach an excellent reliability in one third of the parameters, a training session for participants is needed and at least seven trials of two

  2. Reliability of System Identification Techniques to Assess Standing Balance in Healthy Elderly.

    Science.gov (United States)

    Pasma, Jantsje H; Engelhart, Denise; Maier, Andrea B; Aarts, Ronald G K M; van Gerven, Joop M A; Arendzen, J Hans; Schouten, Alfred C; Meskers, Carel G M; van der Kooij, Herman

    2016-01-01

    System identification techniques have the potential to assess the contribution of the underlying systems involved in standing balance by applying well-known disturbances. We investigated the reliability of standing balance parameters obtained with multivariate closed loop system identification techniques. In twelve healthy elderly balance tests were performed twice a day during three days. Body sway was measured during two minutes of standing with eyes closed and the Balance test Room (BalRoom) was used to apply four disturbances simultaneously: two sensory disturbances, to the proprioceptive and the visual system, and two mechanical disturbances applied at the leg and trunk segment. Using system identification techniques, sensitivity functions of the sensory disturbances and the neuromuscular controller were estimated. Based on the generalizability theory (G theory), systematic errors and sources of variability were assessed using linear mixed models and reliability was assessed by computing indexes of dependability (ID), standard error of measurement (SEM) and minimal detectable change (MDC). A systematic error was found between the first and second trial in the sensitivity functions. No systematic error was found in the neuromuscular controller and body sway. The reliability of 15 of 25 parameters and body sway were moderate to excellent when the results of two trials on three days were averaged. To reach an excellent reliability on one day in 7 out of 25 parameters, it was predicted that at least seven trials must be averaged. This study shows that system identification techniques are a promising method to assess the underlying systems involved in standing balance in elderly. However, most of the parameters do not appear to be reliable unless a large number of trials are collected across multiple days. To reach an excellent reliability in one third of the parameters, a training session for participants is needed and at least seven trials of two minutes must be

  3. Reforming the Health Care System for Children and the Elderly to Balance Cure and Care.

    Science.gov (United States)

    Callahan, Daniel

    1992-01-01

    Issues in balancing health services and costs in a changing society, where groups have differential access to health care, are discussed, including need for a universal health care system, growing cost of health care for the elderly, prolongation of life among older adults, and the claims of children on services. (MSE)

  4. Balanced Realization and Model Order Reduction for Nonlinear Systems based on Singular Value Analysis

    NARCIS (Netherlands)

    Fujimoto, Kenji; Scherpen, Jacquelien M. A.

    2010-01-01

    This paper discusses balanced realization and model order reduction for both continuous-time and discrete-time general nonlinear systems based on singular value analysis of the corresponding Hankel operators. Singular value analysis clarifies the gain structure of a given nonlinear operator. Here it

  5. A high performance GPU implementation of Surface Energy Balance System (SEBS) based on CUDA-C

    NARCIS (Netherlands)

    Abouali, Mohammad; Timmermans, J.; Castillo, Jose E.; Su, Zhongbo

    2013-01-01

    This paper introduces a new implementation of the Surface Energy Balance System (SEBS) algorithm harnessing the many cores available on Graphics Processing Units (GPUs). This new implementation uses Compute Unified Device Architecture C (CUDA-C) programming model and is designed to be executed on a

  6. Carrier Load Balancing and Packet Scheduling for Multi-Carrier Systems

    DEFF Research Database (Denmark)

    Wang, Yuanye; Pedersen, Klaus; Sørensen, Troels Bundgaard

    2010-01-01

    methods for allocating the CCs to the users- Round Robin (RR) and Mobile Hashing (MH) balancing by means of a simple theoretical formulation, as well as system level simulations. At Layer-2 we propose a simple cross-CC packet scheduling algorithm that improves the coverage performance and the resource...

  7. 26 CFR 801.1 - Balanced performance measurement system; in general.

    Science.gov (United States)

    2010-04-01

    ...: Customer Satisfaction Measures; Employee Satisfaction Measures; and Business Results Measures. The IRS is... 26 Internal Revenue 20 2010-04-01 2010-04-01 false Balanced performance measurement system; in general. 801.1 Section 801.1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE...

  8. A high performance GPU implementation of Surface Energy Balance System (SEBS) based on CUDA-C

    NARCIS (Netherlands)

    Abouali, Mohammad; Timmermans, Joris; Castillo, Jose E.; Su, Bob Z.

    2013-01-01

    This paper introduces a new implementation of the Surface Energy Balance System (SEBS) algorithm harnessing the many cores available on Graphics Processing Units (GPUs). This new implementation uses Compute Unified Device Architecture C (CUDA-C) programming model and is designed to be executed on a

  9. A Monolithic Double-balanced Upconverter for millimeter-wave Point-to-Multipoint Distribution Systems

    OpenAIRE

    Ang, K S; Robertson, I.D.

    2000-01-01

    The design and performance of a monolithic double-balanced upconverter for mm-wave point-to- multipoint distribution systems are presented. Individual building blocks including the LO /RF balun, IF balun,LO /RF power amplifier,and the double- balanced mixer are also fabricated and tested.The complete upconverter,measuring 3x3.2mm,upconverts the 3 -5GHz IF to 40.5 -43.5GHz band with 20 dBm output power.

  10. Space vector modulation strategy for neutral-point voltage balancing in three-level inverter systems

    DEFF Research Database (Denmark)

    Choi, Uimin; Lee, Kyo Beum

    2013-01-01

    This study proposes a space vector modulation (SVM) strategy to balance the neutral-point voltage of three-level inverter systems. The proposed method is implemented by combining conventional symmetric SVM with nearest three-vector (NTV) modulation. The conventional SVM is converted to NTV...... modulation by properly adding or subtracting a minimum gate-on time. In addition, using this method, the switching frequency is reduced and a decrease of switching loss would be yielded. The neutral-point voltage is balanced by the proposed SVM strategy without additional hardware or complex calculations...

  11. The Surface Energy Balance System (SEBS for estimation of turbulent heat fluxes

    Directory of Open Access Journals (Sweden)

    Z. Su

    2002-01-01

    Full Text Available A Surface Energy Balance System (SEBS is proposed for the estimation of atmospheric turbulent fluxes and evaporative fraction using satellite earth observation data, in combination with meteorological information at proper scales. SEBS consists of: a set of tools for the determination of the land surface physical parameters, such as albedo, emissivity, temperature, vegetation coverage etc., from spectral reflectance and radiance measurements; a model for the determination of the roughness length for heat transfer; and a new formulation for the determination of the evaporative fraction on the basis of energy balance at limiting cases. Four experimental data sets are used to assess the reliabilities of SEBS. Based on these case studies, SEBS has proven to be capable to estimate turbulent heat fluxes and evaporative fraction at various scales with acceptable accuracy. The uncertainties in the estimated heat fluxes are comparable to in-situ measurement uncertainties. Keywords: Surface energy balance, turbulent heat flux, evaporation, remote sensing

  12. Evaluation of Advanced Control for Li-ion Battery Balancing Systems using Convex Optimization

    DEFF Research Database (Denmark)

    Pinto, Claudio; Barreras, Jorge Varela; Schaltz, Erik

    2016-01-01

    of energy losses, available capacity or temperature are obtained for the last three categories, even for moderate balancing currents. In particular, remarkable improvements are observed under conditions of high power demand with high variability, i.e., smaller battery sizes and more demanding driving cycles....... systems are evaluated in this paper by means of convex optimization. More than one hundred cases in a pure EV application are evaluated. Balancing circuits' efficiency models are implemented and realistic cell-to-cell parameter distributions are considered based on experimental data. Different battery...... sizes and driving cycles are considered. Balancing circuit topology is taken into account by selecting a specific category of energy transfer: cell-to-heat, bypass, cell-to-pack, pack-to-cell, cell-to-cell shared, cell-to-cell distributed or cell-to-pack-to-cell. In general, better results in terms...

  13. Effects of feed loading on nitrogen balances and fish performance in replicated recirculating aquaculture systems

    DEFF Research Database (Denmark)

    Pedersen, Lars-Flemming; Suhr, Karin Isabel; Dalsgaard, Anne Johanne Tang

    2012-01-01

    /L at steady state, and the concentration of nitrogenous compounds and organic matter were all positively correlated to feed loading.The TAN loading to the RAS from the specific feed type was assessed in a separate mass-balance study and used as input in a descriptive mathematical model (AQUASIM® software......This study investigated the effects of applying four fixed feed loadings to three replicated recirculating aquaculture systems (RAS) on water quality changes, nitrogenous balances and growth performance of rainbow trout (Oncorhynchus mykiss).Feed loadings ranged from 1.6 to 6.3kgfeed/m3 make......) developed to simulate processes affecting N mass-balances in the RAS. Nitrification kinetic rate constants were applied to the biofilter, and fractions of nitrifiers in suspended solids in the water phase were estimated based on existing information from waste water treatment processes. Two model scenarios...

  14. Integration of microalgae systems at municipal wastewater treatment plants: implications for energy and emission balances.

    Science.gov (United States)

    Menger-Krug, Eve; Niederste-Hollenberg, Jutta; Hillenbrand, Thomas; Hiessl, Harald

    2012-11-06

    Integrating microalgae systems (MAS) at municipal wastewater treatment plants (WWTPs) to produce of bioenergy offers many potential synergies. Improved energy balances provide a strong incentive for WWTPs to integrate MAS, but it is crucial that WWTPs maintain their barrier function to protect water resources. We perform a prospective analysis of energy and emission balances of a WWTP with integrated MAS, based on a substance flow analysis of the elements carbon (C), nitrogen (N), and phosphorus (P). These elements are the main ingredients of wastewater, and the key nutrients for algae growth. We propose a process design which relies solely on resources from wastewater with no external input of water, fertilizer or CO(2). The whole process chain, from cultivation to production of bioelectricity, takes place at the WWTP. Our results show that MAS can considerably improve energy balances of WWTPs without any external resource input. With optimistic assumptions, they can turn WWTPs into net energy producers. While intensive C recycling in MAS considerably improves the energy balance, we show that it also impacts on effluent quality. We discuss the importance of nonharvested biomass for effluent quality and highlight harvesting efficiency as key factor for energy and emission balances of MAS at WWTP.

  15. Human Factors Considerations in System Design

    Science.gov (United States)

    Mitchell, C. M. (Editor); Vanbalen, P. M. (Editor); Moe, K. L. (Editor)

    1983-01-01

    Human factors considerations in systems design was examined. Human factors in automated command and control, in the efficiency of the human computer interface and system effectiveness are outlined. The following topics are discussed: human factors aspects of control room design; design of interactive systems; human computer dialogue, interaction tasks and techniques; guidelines on ergonomic aspects of control rooms and highly automated environments; system engineering for control by humans; conceptual models of information processing; information display and interaction in real time environments.

  16. Functional near-infrared spectroscopy (fNIRS) of brain function during active balancing using a video game system.

    Science.gov (United States)

    Karim, Helmet; Schmidt, Benjamin; Dart, Dwight; Beluk, Nancy; Huppert, Theodore

    2012-03-01

    Functional near-infrared spectroscopy (fNIRS) is a portable, non-invasive, brain imaging technology that uses low levels of non-ionizing light to record changes in cerebral blood flow in the brain through optical sensors placed on the surface of the scalp. These signals are recorded via flexible fiber optic cables, which allow neuroimaging experiments to be conducted on participants while performing tasks such as standing or walking. FNIRS has the potential to provide new insights into the evolution of brain activation during ambulatory motor learning tasks and standing tasks to probe balance and vestibular function. In this study, a 32 channel fNIRS system was used to record blood flow changes in the frontal, motor, sensory, and temporal cortices during active balancing associated with playing a video game simulating downhill skiing (Nintendo Wii™; Wii-fit™). Using fNIRS, we found activation of superior temporal gyrus, which was modulated by the difficulty of the balance task. This region had been previously implicated in vestibular function from other animal and human studies. Copyright © 2011 Elsevier B.V. All rights reserved.

  17. Marketing residential grid-connected PV systems using a balanced scorecard as a marketing tool

    Energy Technology Data Exchange (ETDEWEB)

    Bach, N. [University of Giessen (Germany). Dept. of Organisation and Management; Calais, P. [Murdoch University, Perth (Australia). School of Environmental Science; Calais, M. [Curtin University, Perth (Australia). Centre for Renewable Systems Technology

    2001-03-01

    A strategic analysis of the electricity market in Western Australia yields a market potential for renewable energy in Western Australia. However, from a purely financial viewpoint the installation of grid-connected pv-systems still is not economically viable. In this paper a balanced scorecard (BSC) is developed to capture and visualize other than financial benefits. Therefore, the BSC can be used as a marketing tool to communicate the benefits of a privately owned GCPV system to potential customers. (author)

  18. What balance do countries exhibit between the central human resources: water, energy and food

    Science.gov (United States)

    Kossak, Julian; Reusser, Dominik E.; Kropp, Jürgen P.

    2013-04-01

    Sufficient water, food and energy is a precondition for human activities. The water, energy and food nexus states that to some extend, these resources can replace each another: land can be used to produce food or energy crops; water can be used as direct water supply, to produce energy or for irrigation; and energy supports water treatment and agricultural yield. We present an overview of the major components of the trade-off together with a set of indicators and data sources to assess these components. The different indicators of the trade-off are summarized and plotted in a novel way on a triangle, which we discuss in view of the resource availability of different countries. Comparing different countries in view of their balance between water, food and energy will inform the discussion about the transition towards more sustainable societies and highlighting alternative strategies for development. This is important in view of possible synergies between the different sectors and as a tool for better coordinated governance approaches.

  19. Human-system Interfaces for Automatic Systems

    Energy Technology Data Exchange (ETDEWEB)

    OHara, J.M.; Higgins,J. (BNL); Fleger, S.; Barnes V. (NRC)

    2010-11-07

    Automation is ubiquitous in modern complex systems, and commercial nuclear- power plants are no exception. Automation is applied to a wide range of functions including monitoring and detection, situation assessment, response planning, and response implementation. Automation has become a 'team player' supporting personnel in nearly all aspects of system operation. In light of its increasing use and importance in new- and future-plants, guidance is needed to conduct safety reviews of the operator's interface with automation. The objective of this research was to develop such guidance. We first characterized the important HFE aspects of automation, including six dimensions: levels, functions, processes, modes, flexibility, and reliability. Next, we reviewed literature on the effects of all of these aspects of automation on human performance, and on the design of human-system interfaces (HSIs). Then, we used this technical basis established from the literature to identify general principles for human-automation interaction and to develop review guidelines. The guidelines consist of the following seven topics: automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration. In addition, our study identified several topics for additional research.

  20. Automatic balancing of AMB systems using plural notch filter and adaptive synchronous compensation

    Science.gov (United States)

    Xu, Xiangbo; Chen, Shao; Zhang, Yanan

    2016-07-01

    To achieve automatic balancing in active magnetic bearing (AMB) system, a control method with notch filters and synchronous compensators is widely employed. However, the control precision is significantly affected by the synchronous compensation error, which is caused by parameter errors and variations of the power amplifiers. Furthermore, the computation effort may become intolerable if a 4-degree-of-freedom (dof) AMB system is studied. To solve these problems, an adaptive automatic balancing control method in the AMB system is presented in this study. Firstly, a 4-dof radial AMB system is described and analyzed. To simplify the controller design, the 4-dof dynamic equations are transferred into two plural functions related to translation and rotation, respectively. Next, to achieve automatic balancing of the AMB system, two synchronous equations are formed. Solution of them leads to a control strategy based on notch filters and feedforward controllers with an inverse function of the power amplifier. The feedforward controllers can be simplified as synchronous phases and amplitudes. Then, a plural phase-shift notch filter which can identify the synchronous components in 2-dof motions is formulated, and an adaptive compensation method that can form two closed-loop systems to tune the synchronous amplitude of the feedforward controller and the phase of the plural notch filter is proposed. Finally, the proposed control strategy is verified by both simulations and experiments on a test rig of magnetically suspended control moment gyro. The results indicate that this method can fulfill the automatic balancing of the AMB system with a light computational load.

  1. Hydrological functioning and water balance in a heavily modified hydrographic system

    Science.gov (United States)

    Carbonnel, Vincent; Brion, Natacha; Elskens, Marc; Claeys, Philippe; Verbanck, Michel A.

    2017-04-01

    Rivers and canals are often the location for the historical settlement of cities and the backbone for their expansion, as they permit the transport of goods and people, the access to water for industrial activities and energy production, and the evacuation of the domestic and industrial wastewaters. In turn, human activities can result in modifications of the natural river systems to allow for instance ship transport or protection against flooding. The complex interconnected hydrographic network composed of the Zenne and the parallel Charleroi-Brussels-Scheldt Canal, which supports the development of the economy and urbanization of Brussels Metropolitan Area (Belgium), is a good example of such an altered system. The natural water course has been profoundly modified by the deviation of rivers to feed the canal, the control of the water flow in the canal by locks and pumps and the overflow exchange of water between the river and the canal for flood protection purposes. Also, the functioning of this system is strongly impacted by urban hydrology in Brussels, which results in amounts of wastewater discharged in the Zenne River that are nearly equivalent to the natural riverine flow. Water and water quality management in such complex and altered systems correspond to difficult tasks. They require, as a first step, a deep understanding of their hydrological functioning. Building an accurate water budget is also a necessary step in the investigation of the pollution sources, sinks, dynamics and mass-balance. In order to assess the water quality and provide insights for water management in the Zenne-Canal hydrographic network (cf. other contributions in this session), we established a detailed box-model representation of the water budget for the whole system, with a particular interest on the importance and the effects of the exchanges of water between the river and the canal. A particularity of this study is that, in contrast to the widespread use of hydrological

  2. Balancing the books – a statistical theory of prospective budgets in Earth System science

    Directory of Open Access Journals (Sweden)

    J. P. O'Kane

    2003-01-01

    Full Text Available An honest declaration of the error in a mass, momentum or energy balance, ε, simply raises the question of its acceptability: 'At what value of ε is the attempted balance to be rejected?' Answering this question requires a reference quantity against which to compare ε. This quantity must be a mathematical function of all the data used in making the balance. To deliver this function, a theory grounded in a workable definition of acceptability is essential. A distinction must be drawn between a retrospective balance and a prospective budget in relation to any natural space-filling body. Balances look to the past; budgets look to the future. The theory is built on the application of classical sampling theory to the measurement and closure of a prospective budget. It satisfies R.A. Fisher's 'vital requirement that the actual and physical conduct of experiments should govern the statistical procedure of their interpretation'. It provides a test, which rejects, or fails to reject, the hypothesis that the closing error on the budget, when realised, was due to sampling error only. By increasing the number of measurements, the discrimination of the test can be improved, controlling both the precision and accuracy of the budget and its components. The cost-effective design of such measurement campaigns is discussed briefly. This analysis may also show when campaigns to close a budget on a particular space-filling body are not worth the effort for either scientific or economic reasons. Other approaches, such as those based on stochastic processes, lack this finality, because they fail to distinguish between different types of error in the mismatch between a set of realisations of the process and the measured data. Keywords: balance, budget, sampling, hypothesis test, closing error, Earth System

  3. Reliability of the Balance Evaluation Systems Test (BESTest) and BESTest sections for adults with hemiparesis.

    Science.gov (United States)

    Rodrigues, Letícia C; Marques, Aline P; Barros, Paula B; Michaelsen, Stella M

    2014-01-01

    The Balance Evaluation Systems Test (BESTest) was recently created to allow the development of treatments according to the specific balance system affected in each patient. The Brazilian version of the BESTest has not been specifically tested after stroke. To evaluate the intra- and inter-rater reliability and concurrent and convergent validity of the total score of the BESTest and BESTest sections for adults with hemiparesis after stroke. The study included 16 subjects (61.1 ± 7.5 years) with chronic hemiparesis (54.5 ± 43.5 months after stroke). The BESTest was administered by two raters in the same week and one of the raters repeated the test after a one-week interval. Intraclass correlation coefficient (ICC) was calculated to assess intra- and interrater reliability. Concurrent validity with the Berg Balance Scale (BBS) and convergent validity with the Activities-specific Balance Confidence scale (ABC-Brazil) were assessed using Pearson's correlation coefficient. Both the BESTest total score (ICC=0.98) and the BESTest sections (ICC between 0.85 and 0.96) have excellent intrarater reliability. Interrater reliability for the total score was excellent (ICC=0.93) and, for the sections, it ranged between 0.71 and 0.94. The correlation coefficient between the BESTest and the BBS and ABC-Brazil were 0.78 and 0.59, respectively. The Brazilian version of the BESTest demonstrated adequate reliability when measured by sections and could identify what balance system was affected in patients after stroke. Concurrent validity was excellent with the BBS total score and good to excellent with the sections. The total scores but not the sections present adequate convergent validity with the ABC-Brazil. However, other psychometric properties should be further investigated.

  4. Reliability of the Balance Evaluation Systems Test (BESTest and BESTest sections for adults with hemiparesis

    Directory of Open Access Journals (Sweden)

    Letícia C. Rodrigues

    2014-07-01

    Full Text Available BACKGROUND: The Balance Evaluation Systems Test (BESTest was recently created to allow the development of treatments according to the specific balance system affected in each patient. The Brazilian version of the BESTest has not been specifically tested after stroke. OBJECTIVE: To evaluate the intra- and inter-rater reliability and concurrent and convergent validity of the total score of the BESTest and BESTest sections for adults with hemiparesis after stroke. METHOD: The study included 16 subjects (61.1±7.5 years with chronic hemiparesis (54.5±43.5 months after stroke. The BESTest was administered by two raters in the same week and one of the raters repeated the test after a one-week interval. Intraclass correlation coefficient (ICC was calculated to assess intra- and interrater reliability. Concurrent validity with the Berg Balance Scale (BBS and convergent validity with the Activities-specific Balance Confidence scale (ABC-Brazil were assessed using Pearson's correlation coefficient. RESULTS: Both the BESTest total score (ICC=0.98 and the BESTest sections (ICC between 0.85 and 0.96 have excellent intrarater reliability. Interrater reliability for the total score was excellent (ICC=0.93 and, for the sections, it ranged between 0.71 and 0.94. The correlation coefficient between the BESTest and the BBS and ABC-Brazil were 0.78 and 0.59, respectively. CONCLUSIONS: The Brazilian version of the BESTest demonstrated adequate reliability when measured by sections and could identify what balance system was affected in patients after stroke. Concurrent validity was excellent with the BBS total score and good to excellent with the sections. The total scores but not the sections present adequate convergent validity with the ABC-Brazil. However, other psychometric properties should be further investigated.

  5. Cell-balancing currents in parallel strings of a battery system

    Science.gov (United States)

    Dubarry, Matthieu; Devie, Arnaud; Liaw, Bor Yann

    2016-07-01

    Lithium-ion batteries are attractive for vehicle electrification or grid modernization applications. In these applications, battery packs are required to have multiple-cell configurations and battery management system to operate properly and safely. Here, a useful equivalent circuit model was developed to simulate the spontaneous transient balancing currents among parallel strings in a battery system. The simulation results were validated with experimental data to illustrate the accuracy and validity of the model predictions. Understanding the transient behavior of such cell and string balancing in a parallel circuit configuration is very important to assess the impacts of current fluctuation and cell variability on a battery system's performance, regarding durability, reliability, safety, abuse tolerance and failure prevention, including possible short circuit or open circuit conditions. Additional features and advantages, including the ability to assessing impacts on the performance of the string assemblies from string swapping or cell/module replacement in the strings, could be realized to aid battery management, maintenance and repair.

  6. New insights on the role of the endocannabinoid system in the regulation of energy balance.

    Science.gov (United States)

    Gatta-Cherifi, B; Cota, D

    2016-02-01

    Within the past 15 years, the endocannabinoid system (ECS) has emerged as a lipid signaling system critically involved in the regulation of energy balance, as it exerts a regulatory control on every aspect related to the search, the intake, the metabolism and the storage of calories. An overactive endocannabinoid cannabinoid type 1 (CB1) receptor signaling promotes the development of obesity, insulin resistance and dyslipidemia, representing a valuable pharmacotherapeutic target for obesity and metabolic disorders. However, because of the psychiatric side effects, the first generation of brain-penetrant CB1 receptor blockers developed as antiobesity treatment were removed from the European market in late 2008. Since then, recent studies have identified new mechanisms of action of the ECS in energy balance and metabolism, as well as novel ways of targeting the system that may be efficacious for the treatment of obesity and metabolic disorders. These aspects will be especially highlighted in this review.

  7. 76 FR 2368 - Balance Power Systems, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2011-01-13

    ... Energy Regulatory Commission Balance Power Systems, LLC; Supplemental Notice That Initial Market-Based... supplemental notice in the above-referenced proceeding of Balance Power Systems, LLC's application for market... 20426. The filings in the above-referenced proceeding are accessible in the Commission's eLibrary...

  8. Analysing chaos in fractional-order systems with the harmonic balance method

    Institute of Scientific and Technical Information of China (English)

    Wu Zheng-Mao; Lu Jun-Guo; Xie Jian-Ying

    2006-01-01

    In this paper, the fractional-order Genesio-Tesi system showing chaotic behaviours is introduced, and the corresponding one in an integer-order form is studied intensively. Based on the harmonic balance principle, which is widely used in the frequency analysis of nonlinear control systems, a theoretical approach is used to investigate the conditions of system parameters under which this fractional-order system can give rise to a chaotic attractor. Finally, the numerical simulation is used to verify the validity of the theoretical results.

  9. Chaos control and global synchronization of Liu chaotic systems using linear balanced feedback control

    Energy Technology Data Exchange (ETDEWEB)

    Chen, H.-H. [Department of Mechanical Engineering, HsiuPing Institute of Technology, Taichung 412, Taiwan (China)], E-mail: richard@mail.hit.edu.tw

    2009-04-15

    Liu chaotic systems exhibit two- or four-scroll attractors and are observed in a variety of engineering phenomena, including rigid body motion, brushless DC motor system and so forth. This study applies the Lyapunov stability theorem to identify the sufficient conditions for the asymptotic stability of the equilibrium points of Liu chaotic systems. A linear balanced feedback gain control method is then employed to design a controller to achieve the global synchronization of two identical four-scroll Liu chaotic systems. The feasibility and effectiveness of the proposed chaos stability and synchronization schemes are verified via numerical simulations.

  10. Dizziness and Balance

    Science.gov (United States)

    AUDIOLOGY Dizziness and Balance Inform ation Seri es Our balance system helps us walk, run, and move without falling. ... if I have a problem with balance or dizziness? It is important to see your doctor if ...

  11. Human nervous system function emulator.

    Science.gov (United States)

    Frenger, P

    2000-01-01

    This paper describes a modular, extensible, open-systems design for a multiprocessor network which emulates the major functions of the human nervous system. Interchangeable hardware/software components, a socketed software bus with plug-and-play capability and self diagnostics are included. The computer hardware is based on IEEE P996.1 bus cards. Its operating system utilizes IEEE 1275 standard software. Object oriented design techniques and programming are featured. A machine-independent high level script-based command language was created for this project. Neural anatomical structures which were emulated include the cortex, brainstem, cerebellum, spinal cord, autonomic and peripheral nervous systems. Motor, sensory, autoregulatory, and higher cognitive artificial intelligence, behavioral and emotional functions are provided. The author discusses how he has interfaced this emulator to machine vision, speech recognition/speech synthesis, an artificial neural network and a dexterous hand to form an android robotic platform.

  12. Mizan: A system for dynamic load balancing in large-scale graph processing

    KAUST Repository

    Khayyat, Zuhair

    2013-01-01

    Pregel [23] was recently introduced as a scalable graph mining system that can provide significant performance improvements over traditional MapReduce implementations. Existing implementations focus primarily on graph partitioning as a preprocessing step to balance computation across compute nodes. In this paper, we examine the runtime characteristics of a Pregel system. We show that graph partitioning alone is insufficient for minimizing end-to-end computation. Especially where data is very large or the runtime behavior of the algorithm is unknown, an adaptive approach is needed. To this end, we introduce Mizan, a Pregel system that achieves efficient load balancing to better adapt to changes in computing needs. Unlike known implementations of Pregel, Mizan does not assume any a priori knowledge of the structure of the graph or behavior of the algorithm. Instead, it monitors the runtime characteristics of the system. Mizan then performs efficient fine-grained vertex migration to balance computation and communication. We have fully implemented Mizan; using extensive evaluation we show that - especially for highly-dynamic workloads - Mizan provides up to 84% improvement over techniques leveraging static graph pre-partitioning. © 2013 ACM.

  13. The implementation of PAYT system under the condition of financial balance in France.

    Science.gov (United States)

    Le Bozec, André

    2008-12-01

    Since 2005, France has been facing a reform of the financial regulation of the management of municipal solid waste, by tax or flat fees. Nevertheless, the application of unit pricing is limited to about 15 local authorities, but interest is expanding. The French examples confirm the efficiency of this PAYT system. The prevention and the sorting of packaging waste are increasing and the quantity of residual waste falling. But, we have highlighted the difficulty for the local authorities to balance their budgets during the years of PAYT system implementation. After a short review of the situation in France of the financing of waste services, and in particular of PAYT system, the paper presents, firstly the financial model and then, the results of its application in two communities. The cost model takes into account the expenditure of management on various waste flows and the revenues for the sale of by-products. A financial balance is ensured by the payments from households. Consequently, the unit pricing and the effect of the behaviour of the inhabitants are introduced into the simulation model. The application on two local authorities showed that the increase of sorting waste did not restore the balance. From the analysis, three reasons explain this situation: Thus, the development of the tariff must be carried out according to an economic approach. In the end, after the presentation of the financial modelling and its application, we make recommendations to aid the implementation of the PAYT system and the development of the pricing structures by local authorities.

  14. Population-based learning of load balancing policies for a distributed computer system

    Science.gov (United States)

    Mehra, Pankaj; Wah, Benjamin W.

    1993-01-01

    Effective load-balancing policies use dynamic resource information to schedule tasks in a distributed computer system. We present a novel method for automatically learning such policies. At each site in our system, we use a comparator neural network to predict the relative speedup of an incoming task using only the resource-utilization patterns obtained prior to the task's arrival. Outputs of these comparator networks are broadcast periodically over the distributed system, and the resource schedulers at each site use these values to determine the best site for executing an incoming task. The delays incurred in propagating workload information and tasks from one site to another, as well as the dynamic and unpredictable nature of workloads in multiprogrammed multiprocessors, may cause the workload pattern at the time of execution to differ from patterns prevailing at the times of load-index computation and decision making. Our load-balancing policy accommodates this uncertainty by using certain tunable parameters. We present a population-based machine-learning algorithm that adjusts these parameters in order to achieve high average speedups with respect to local execution. Our results show that our load-balancing policy, when combined with the comparator neural network for workload characterization, is effective in exploiting idle resources in a distributed computer system.

  15. Pegasus:a distributed and load-balancing fingerprint identification system*#

    Institute of Scientific and Technical Information of China (English)

    Yun-xiang ZHAO; Wan-xin ZHANG; Dong-sheng LI‡; Zhen HUANG; Min-ne LI; Xi-cheng LU

    2016-01-01

    Fingerprint has been widely used in a variety of biometric identifi cation systems in the past several years due to its uniqueness and immutability. With the rapid development of fi ngerprint identifi cation techniques, many fi ngerprint identifi cation systems are in urgent need to deal with large-scale fi ngerprint storage and high concurrent recognition queries, which bring huge challenges to the system. In this circumstance, we design and implement a distributed and load-balancing fi ngerprint identifi cation system named Pegasus, which includes a distributed feature extraction subsystem and a distributed feature storage subsystem. The feature extraction procedure combines the Hadoop Image Processing Interface (HIPI) library to enhance its overall processing speed; the feature storage subsystem optimizes MongoDB’s default load balance strategy to improve the efficiency and robustness of Pegasus. Experiments and simulations are carried out, and results show that Pegasus can reduce the time cost by 70%during the feature extraction procedure. Pegasus also balances the difference of access load among front-end mongos nodes to less than 5%. Additionally, Pegasus reduces over 40%of data migration among back-end data shards to obtain a more reasonable data distribution based on the operation load (insertion, deletion, update, and query) of each shard.

  16. Heat balance and eddies in the Peru-Chile current system

    Energy Technology Data Exchange (ETDEWEB)

    Colas, Francois; McWilliams, James C.; Kurian, Jaison [University of California, Institute of Geophysics and Planetary Physics, Los Angeles, CA (United States); Capet, Xavier [Laboratoire de Physique des Oceans, Ifremer, Plouzane (France)

    2012-07-15

    The Peru-Chile current System (PCS) is a region of persistent biases in global climate models. It has strong coastal upwelling, alongshore boundary currents, and mesoscale eddies. These oceanic phenomena provide essential heat transport to maintain a cool oceanic surface underneath the prevalent atmospheric stratus cloud deck, through a combination of mean circulation and eddy flux. We demonstrate these behaviors in a regional, quasi-equilibrium oceanic model that adequately resolves the mesoscale eddies with climatological forcing. The key result is that the atmospheric heating is large (>50 W m{sup -2}) over a substantial strip >500 km wide off the coast of Peru, and the balancing lateral oceanic flux is much larger than provided by the offshore Ekman flux alone. The atmospheric heating is weaker and the coastally influenced strip is narrower off Chile, but again the Ekman flux is not sufficient for heat balance. The eddy contribution to the oceanic flux is substantial. Analysis of eddy properties shows strong surface temperature fronts and associated large vorticity, especially off Peru. Cyclonic eddies moderately dominate the surface layer, and anticyclonic eddies, originating from the nearshore poleward Peru-Chile Undercurrent (PCUC), dominate the subsurface, especially off Chile. The sensitivity of the PCS heat balance to equatorial intra-seasonal oscillations is found to be small. We demonstrate that forcing the regional model with a representative, coarse-resolution global reanalysis wind product has dramatic and deleterious consequences for the oceanic circulation and climate heat balance, the eddy heat flux in particular. (orig.)

  17. Human balancing of an inverted pendulum: position control by small, ballistic-like, throw and catch movements.

    Science.gov (United States)

    Loram, Ian D; Lakie, Martin

    2002-05-01

    In standing, there are small sways of the body. Our interest is to use an artificial task to illuminate the mechanisms underlying the sways and to account for changes in their size. Using the ankle musculature, subjects balanced a large inverted pendulum. The equilibrium of the pendulum is unstable and quasi-regular sway was observed like that in quiet standing. By giving full attention to minimising sway subjects could systematically reduce pendulum movement. The pendulum position, the torque generated at each ankle and the soleus and tibialis anterior EMGs were recorded. Explanations about how the human inverted pendulum is balanced usually ignore the fact that balance is maintained over a range of angles and not just at one angle. Any resting equilibrium position of the pendulum is unstable and in practice temporary; movement to a different resting equilibrium position can only be accomplished by a biphasic 'throw and catch' pattern of torque and not by an elastic mechanism. Results showed that balance was achieved by the constant repetition of a neurally generated ballistic-like biphasic pattern of torque which can control both position and sway size. A decomposition technique revealed that there was a substantial contribution to changes in torque from intrinsic mechanical ankle stiffness; however, by itself this was insufficient to maintain balance or to control position. Minimisation of sway size was caused by improvement in the accuracy of the anticipatory torque impulses. We hypothesise that examination of centre of mass and centre of pressure data for quiet standing will duplicate these results.

  18. Energy Storage System Based on Cascaded Multilevel Inverter with Decoupled Energy Balancing Control

    Directory of Open Access Journals (Sweden)

    Cao Yuanzhi

    2015-01-01

    Full Text Available This paper presents a three phase cascaded multilevel inverter based supercapacitor (SC energy storage system with novel structure and control strategy to maintain the energy balance of between phases. Every two phases are coupled with a series LC filter. With the filter, SC cells in different phases could exchange energy with an auxiliary power flow at high frequency. The auxiliary power flow is orthogonal to the primary power flow. The phase difference between high frequency voltage and current components of each phase determines whether the energy is absorbed into or released from its SC cells. Unlike traditional energy balancing strategies, the proposed method is independent to the fundamental real power drawn by the energy storage system. Simulation results confirmed the effects of proposed theories.

  19. Control Volume Analysis, Entropy Balance and the Entropy Production in Flow Systems

    OpenAIRE

    Niven, Robert K.; Noack, Bernd R.

    2014-01-01

    This chapter concerns "control volume analysis", the standard engineering tool for the analysis of flow systems, and its application to entropy balance calculations. Firstly, the principles of control volume analysis are enunciated and applied to flows of conserved quantities (e.g. mass, momentum, energy) through a control volume, giving integral (Reynolds transport theorem) and differential forms of the conservation equations. Several definitions of steady state are discussed. The concept of...

  20. Model Reduction via Time-Interval Balanced Stochastic Truncation for Linear Time Invariant Systems

    DEFF Research Database (Denmark)

    Tahavori, Maryamsadat; Shaker, Hamid Reza

    2013-01-01

    In this article, a new method for model reduction of linear dynamical systems is presented. The proposed technique is from the family of gramian-based relative error model reduction methods. The method uses time-interval gramians in the reduction procedure rather than ordinary gramians and in suc...... player example. The numerical results show that the method is more accurate than ordinary balanced stochastic truncation....

  1. Chaos control via TDFC in time-delayed systems: The harmonic balance approach

    Energy Technology Data Exchange (ETDEWEB)

    Vasegh, Nastaran [Faculty of Electrical Engineering, K.N. Toosi University of Technology, PO Box 16315-1355, Tehran (Iran, Islamic Republic of)], E-mail: vasegh@eetd.kntu.ac.ir; Khaki Sedigh, Ali [Faculty of Electrical Engineering, K.N. Toosi University of Technology, PO Box 16315-1355, Tehran (Iran, Islamic Republic of)

    2009-01-12

    This Letter deals with the problem of designing time-delayed feedback controllers (TDFCs) to stabilize unstable equilibrium points and periodic orbits for a class of continuous time-delayed chaotic systems. Harmonic balance approach is used to select the appropriate controller parameters: delay time and feedback gain. The established theoretical results are illustrated via a case study of the well-known Logistic model.

  2. A Balanced Approach to Capturing User Requirements in Business- to- Consumer Web Information Systems

    Directory of Open Access Journals (Sweden)

    M. S. Lane

    2001-11-01

    Full Text Available The development of business-to-consumer web information systems pose special challenges in the requirements analysis phase. It is difficult to capture user requirements given that users are relatively autonomous and anonymous and there are no major incentives for users to become involved in the development of a web information system. The researchers reviewed traditional requirement elicitation techniques, marketing research techniques and web usage analysis techniques. Current practice was assessed and the findings suggest that a balanced approach to user requirements capture will result in more complete and user centred requirements. This approach should lead to more effective business-to consumer web information systems.

  3. Coordinated Secondary Control for Balanced Discharge Rate of Energy Storage System in Islanded AC Microgrids

    DEFF Research Database (Denmark)

    Guan, Yajuan; Quintero, Juan Carlos Vasquez; Guerrero, Josep M.

    2016-01-01

    incidents and unintentional outages in DG units, but also aims to provide a fast transient response and an accurate output-current-sharing performance. A complete root locus analysis is given in order to achieve system stability and parameter sensitivity. Experimental results are presented to show......A coordinated secondary control approach based on an autonomous current-sharing control strategy for balancing the discharge rates of energy storage systems (ESSs) in islanded AC microgrids is proposed in this paper. The coordinated secondary controller can regulate the power outputs of distributed...... the performance of the whole system and to verify the effectiveness of the proposed controller....

  4. Performance Management through a Balanced Scorecard - A SystemsDynamics Modelling Approach

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

    The object of this paper is to show how - normally separate practices - can be linked together to support the performance management system in a balanced scorecard framework. The monitor and learn of the strategy evaluation and the feedback process is important for the company to be on track....... Building mainly on [Kaplan, R. S. & Norton, D. P. (2008) 'Mastering the Management System, Harvard Business Review, January, 2008); Ferreira A. & Otley, D. (2005). The Design and Use of Management Control Systems: An Extended Framework for Analysis, Working Paper; and Sterman, J. D. (2000), Business...

  5. Mass balance and life cycle assessment of the waste electrical and electronic equipment management system implemented in Lombardia Region (Italy).

    Science.gov (United States)

    Biganzoli, L; Falbo, A; Forte, F; Grosso, M; Rigamonti, L

    2015-08-15

    Waste electrical and electronic equipment (WEEE) is one of the fastest growing waste streams in Europe, whose content of hazardous substances as well as of valuable materials makes the study of the different management options particularly interesting. The present study investigates the WEEE management system in Lombardia Region (Italy) in the year 2011 by applying the life cycle assessment (LCA) methodology. An extensive collection of primary data was carried out to describe the main outputs and the energy consumptions of the treatment plants. Afterwards, the benefits and burdens associated with the treatment and recovery of each of the five categories in which WEEE is classified according to the Italian legislation (heaters and refrigerators - R1, large household appliances - R2, TV and monitors - R3, small household appliances - R4 and lighting equipment - R5) were evaluated. The mass balance of the treatment and recovery system of each of the five WEEE categories showed that steel and glass are the predominant streams of materials arising from the treatment; a non-negligible amount of plastic is also recovered, together with small amounts of precious metals. The LCA of the regional WEEE management system showed that the benefits associated with materials and energy recovery balance the burdens of the treatment processes, with the sole exception of two impact categories (human toxicity-cancer effects and freshwater ecotoxicity). The WEEE categories whose treatment and recovery resulted more beneficial for the environment and the human health are R3 and R5. The contribution analysis showed that overall the main benefits are associated with the recovery of metals, as well as of plastic and glass. Some suggestions for improving the performance of the system are given, as well as an indication for a more-in-depth analysis for the toxicity categories and a proposal for a new characterisation method for WEEE.

  6. A Human Body Analysis System

    Directory of Open Access Journals (Sweden)

    Girondel Vincent

    2006-01-01

    Full Text Available This paper describes a system for human body analysis (segmentation, tracking, face/hands localisation, posture recognition from a single view that is fast and completely automatic. The system first extracts low-level data and uses part of the data for high-level interpretation. It can detect and track several persons even if they merge or are completely occluded by another person from the camera's point of view. For the high-level interpretation step, static posture recognition is performed using a belief theory-based classifier. The belief theory is considered here as a new approach for performing posture recognition and classification using imprecise and/or conflicting data. Four different static postures are considered: standing, sitting, squatting, and lying. The aim of this paper is to give a global view and an evaluation of the performances of the entire system and to describe in detail each of its processing steps, whereas our previous publications focused on a single part of the system. The efficiency and the limits of the system have been highlighted on a database of more than fifty video sequences where a dozen different individuals appear. This system allows real-time processing and aims at monitoring elderly people in video surveillance applications or at the mixing of real and virtual worlds in ambient intelligence systems.

  7. A compact wideband precision impedance measurement system based on digital auto-balancing bridge

    Science.gov (United States)

    Hu, Binxin; Wang, Jinyu; Song, Guangdong; Zhang, Faxiang

    2016-05-01

    The ac impedance spectroscopy measurements are predominantly taken by using impedance analyzers based on analog auto-balancing bridge. However, those bench-top analyzers are generally complicated, bulky and expensive, thus limiting their usage in industrial field applications. This paper presents the development of a compact wideband precision measurement system based on digital auto-balancing bridge. The methods of digital auto-balancing bridge and digital lock-in amplifier are analyzed theoretically. The overall design and several key sections including null detector, direct digital synthesizer-based sampling clock, and digital control unit are introduced in detail. The results show that the system achieves a basic measurement accuracy of 0.05% with a frequency range of 20 Hz-2 MHz. The advantages of versatile measurement capacity, fast measurement speed, small size and low cost make it quite suitable for industrial field applications. It is demonstrated that this system is practical and effective by applying in determining the impedance-temperature characteristic of a motor starter PTC thermistor.

  8. Tradeoffs in the design of health plan payment systems: Fit, power and balance.

    Science.gov (United States)

    Geruso, Michael; McGuire, Thomas G

    2016-05-01

    In many markets, including the new U.S. Marketplaces, health insurance plans are paid by risk-adjusted capitation, sometimes combined with reinsurance and other payment mechanisms. This paper proposes a framework for evaluating the de facto insurer incentives embedded in these complex payment systems. We discuss fit, power and balance, each of which addresses a distinct market failure in health insurance. We implement empirical metrics of fit, power, and balance in a study of Marketplace payment systems. Using data similar to that used to develop the Marketplace risk adjustment scheme, we quantify tradeoffs among the three classes of incentives. We show that an essential tradeoff arises between the goals of limiting costs and limiting cream skimming because risk adjustment, which is aimed at discouraging cream-skimming, weakens cost control incentives in practice. A simple reinsurance system scores better on our measures of fit, power and balance than the risk adjustment scheme in use in the Marketplaces. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. MEMS Technology Sensors as a More Advantageous Technique for Measuring Foot Plantar Pressure and Balance in Humans

    Directory of Open Access Journals (Sweden)

    Clara Sanz Morère

    2016-01-01

    Full Text Available Locomotor activities are part and parcel of daily human life. During walking or running, feet are subjected to high plantar pressure, leading sometimes to limb problems, pain, or foot ulceration. A current objective in foot plantar pressure measurements is developing sensors that are small in size, lightweight, and energy efficient, while enabling high mobility, particularly for wearable applications. Moreover, improvements in spatial resolution, accuracy, and sensitivity are of interest. Sensors with improved sensing techniques can be applied to a variety of research problems: diagnosing limb problems, footwear design, or injury prevention. This paper reviews commercially available sensors used in foot plantar pressure measurements and proposes the utilization of pressure sensors based on the MEMS (microelectromechanical systems technique. Pressure sensors based on this technique have the capacity to measure pressure with high accuracy and linearity up to high pressure levels. Moreover, being small in size, they are highly suitable for this type of measurement. We present two MEMS sensor models and study their suitability for the intended purpose by performing several experiments. Preliminary results indicate that the sensors are indeed suitable for measuring foot plantar pressure. Importantly, by measuring pressure continuously, they can also be utilized for body balance measurements.

  10. Assessment of Multi-Joint Coordination and Adaptation in Standing Balance: A Novel Device and System Identification Technique.

    Science.gov (United States)

    Engelhart, Denise; Schouten, Alfred C; Aarts, Ronald G K M; van der Kooij, Herman

    2015-11-01

    The ankles and hips play an important role in maintaining standing balance and the coordination between joints adapts with task and conditions, like the disturbance magnitude and type, and changes with age. Assessment of multi-joint coordination requires the application of multiple continuous and independent disturbances and closed loop system identification techniques (CLSIT). This paper presents a novel device, the double inverted pendulum perturbator (DIPP), which can apply disturbing forces at the hip level and between the shoulder blades. In addition to the disturbances, the device can provide force fields to study adaptation of multi-joint coordination. The performance of the DIPP and a novel CLSIT was assessed by identifying a system with known mechanical properties and model simulations. A double inverted pendulum was successfully identified, while force fields were able to keep the pendulum upright. The estimated dynamics were similar as the theoretical derived dynamics. The DIPP has a sufficient bandwidth of 7 Hz to identify multi-joint coordination dynamics. An experiment with human subjects where a stabilizing force field was rendered at the hip (1500 N/m), showed that subjects adapt by lowering their control actions around the ankles. The stiffness from upper and lower segment motion to ankle torque dropped with 30% and 48%, respectively. Our methods allow to study (pathological) changes in multi-joint coordination as well as adaptive capacity to maintain standing balance.

  11. The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

    NARCIS (Netherlands)

    Redin, Claire; Brand, Harrison; Collins, Ryan L; Kammin, Tammy; Mitchell, Elyse; Hodge, Jennelle C; Hanscom, Carrie; Pillalamarri, Vamsee; Seabra, Catarina M; Abbott, Mary-Alice; Abdul-Rahman, Omar A; Aberg, Erika; Adley, Rhett; Alcaraz-Estrada, Sofia L; Alkuraya, Fowzan S; An, Yu; Anderson, Mary-Anne; Antolik, Caroline; Anyane-Yeboa, Kwame; Atkin, Joan F; Bartell, Tina; Bernstein, Jonathan A; Beyer, Elizabeth; Blumenthal, Ian; Bongers, Ernie M H F; Brilstra, Eva H; Brown, Chester W; Brüggenwirth, Hennie T; Callewaert, Bert; Chiang, Colby; Corning, Ken; Cox, Helen; Cuppen, Edwin; Currall, Benjamin B; Cushing, Tom; David, Dezso; Deardorff, Matthew A; Dheedene, Annelies; D'Hooghe, Marc; de Vries, Bert B A; Earl, Dawn L; Ferguson, Heather L; Fisher, Heather; FitzPatrick, David R; Gerrol, Pamela; Giachino, Daniela; Glessner, Joseph T; Gliem, Troy; Grady, Margo; Graham, Brett H; Griffis, Cristin; Gripp, Karen W; Gropman, Andrea L; Hanson-Kahn, Andrea; Harris, David J; Hayden, Mark A; Hill, Rosamund; Hochstenbach, Ron; Hoffman, Jodi D; Hopkin, Robert J; Hubshman, Monika W; Innes, A Micheil; Irons, Mira; Irving, Melita; Jacobsen, Jessie C; Janssens, Sandra; Jewett, Tamison; Johnson, John P; Jongmans, Marjolijn C; Kahler, Stephen G; Koolen, David A; Korzelius, Jerome; Kroisel, Peter M; Lacassie, Yves; Lawless, William; Lemyre, Emmanuelle; Leppig, Kathleen; Levin, Alex V; Li, Haibo; Li, Hong; Liao, Eric C; Lim, Cynthia; Lose, Edward J; Lucente, Diane; Macera, Michael J; Manavalan, Poornima; Mandrile, Giorgia; Marcelis, Carlo L; Margolin, Lauren; Mason, Tamara; Masser-Frye, Diane; McClellan, Michael W; Mendoza, Cinthya J Zepeda; Menten, Björn; Middelkamp, Sjors; Mikami, Liya R; Moe, Emily; Mohammed, Shehla; Mononen, Tarja; Mortenson, Megan E; Moya, Graciela; Nieuwint, Aggie W; Ordulu, Zehra; Parkash, Sandhya; Pauker, Susan P; Pereira, Shahrin; Perrin, Danielle; Phelan, Katy; Aguilar, Raul E Piña; Poddighe, Pino J; Pregno, Giulia; Raskin, Salmo; Reis, Linda; Rhead, William; Rita, Debra; Renkens, Ivo; Roelens, Filip; Ruliera, Jayla; Rump, Patrick; Schilit, Samantha L P; Shaheen, Ranad; Sparkes, Rebecca; Spiegel, Erica; Stevens, Blair; Stone, Matthew R; Tagoe, Julia; Thakuria, Joseph V; van Bon, Bregje W; van de Kamp, Jiddeke; van Der Burgt, Ineke; van Essen, Ton; van Ravenswaaij-Arts, Conny M; van Roosmalen, Markus J; Vergult, Sarah; Volker-Touw, Catharina M L; Warburton, Dorothy P; Waterman, Matthew J; Wiley, Susan; Wilson, Anna; Yerena-de Vega, Maria de la Concepcion A; Zori, Roberto T; Levy, Brynn; Brunner, Han G; de Leeuw, Nicole; Kloosterman, Wigard P; Thorland, Erik C; Morton, Cynthia C; Gusella, James F; Talkowski, Michael E

    Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing

  12. Voltage Balancing Method on Expert System for 51-Level MMC in High Voltage Direct Current Transmission

    Directory of Open Access Journals (Sweden)

    Yong Chen

    2016-01-01

    Full Text Available The Modular Multilevel Converters (MMC have been a spotlight for the high voltage and high power transmission systems. In the VSC-HVDC (High Voltage Direct Current based on Voltage Source Converter transmission system, the energy of DC link is stored in the distributed capacitors, and the difference of capacitors in parameters and charge rates causes capacitor voltage balance which affects the safety and stability of HVDC system. A method of MMC based on the expert system for reducing the frequency of the submodules (SMs of the IGBT switching frequency is proposed. Firstly, MMC with 51 levels for HVDC is designed. Secondly, the nearest level control (NLC for 51-level MMC is introduced. Thirdly, a modified capacitor voltage balancing method based on expert system for MMC-based HVDC transmission system is proposed. Finally, a simulation platform for 51-level Modular Multilevel Converter is constructed by using MATLAB/SIMULINK. The results indicate that the strategy proposed reduces the switching frequency on the premise of keeping submodule voltage basically identical, which greatly reduces the power losses for MMC-HVDC system.

  13. Vestibular loss and balance training cause similar changes in human cerebral white matter fractional anisotropy.

    Science.gov (United States)

    Hummel, Nadine; Hüfner, Katharina; Stephan, Thomas; Linn, Jennifer; Kremmyda, Olympia; Brandt, Thomas; Flanagin, Virginia L

    2014-01-01

    Patients with bilateral vestibular loss suffer from severe balance deficits during normal everyday movements. Ballet dancers, figure skaters, or slackliners, in contrast, are extraordinarily well trained in maintaining balance for the extreme balance situations that they are exposed to. Both training and disease can lead to changes in the diffusion properties of white matter that are related to skill level or disease progression respectively. In this study, we used diffusion tensor imaging (DTI) to compare white matter diffusivity between these two study groups and their age- and sex-matched controls. We found that vestibular patients and balance-trained subjects show a reduction of fractional anisotropy in similar white matter tracts, due to a relative increase in radial diffusivity (perpendicular to the main diffusion direction). Reduced fractional anisotropy was not only found in sensory and motor areas, but in a widespread network including long-range connections, limbic and association pathways. The reduced fractional anisotropy did not correlate with any cognitive, disease-related or skill-related factors. The similarity in FA between the two study groups, together with the absence of a relationship between skill or disease factors and white matter changes, suggests a common mechanism for these white matter differences. We propose that both study groups must exert increased effort to meet their respective usual balance requirements. Since balance training has been shown to effectively reduce the symptoms of vestibular failure, the changes in white matter shown here may represent a neuronal mechanism for rehabilitation.

  14. Influence of the nonlinear phase and ASE noise on DPSK balanced optical receiver in optical fiber communication system

    Institute of Scientific and Technical Information of China (English)

    李蔚; 梅君瑶; 韩庆生; 王腾

    2009-01-01

    The analytical expression of bit error probability in a balanced differential phase-shift keying(DPSK) optical receiver considering nonlinear phase noise and EDFA ASE noise is given,which is very useful to estimate the performance of DPSK balanced and unbalanced receiver in optical communication system.Through analysis,if only nonlinear phase noise is considered,both the balance and unbalanced receivers have the same performances.But if adding the ASE noise of EDFA,the balanced receiver is better.

  15. Balancing device

    NARCIS (Netherlands)

    Van Dorsser, W.D.; Herder, J.L.; Wisse B.M.; Barents, R.

    2007-01-01

    The invention relates to a balancing device for a mass, comprising an arm that is adjustable about a pivoting point and with which the mass is coupled, and an adjustable spring system that is coupled with the arm, which spring system comprises at least one spring, wherein the spring system comprises

  16. Lithium-Ion Battery Cell-Balancing Algorithm for Battery Management System Based on Real-Time Outlier Detection

    Directory of Open Access Journals (Sweden)

    Changhao Piao

    2015-01-01

    Full Text Available A novel cell-balancing algorithm which was used for cell balancing of battery management system (BMS was proposed in this paper. Cell balancing algorithm is a key technology for lithium-ion battery pack in the electric vehicle field. The distance-based outlier detection algorithm adopted two characteristic parameters (voltage and state of charge to calculate each cell’s abnormal value and then identified the unbalanced cells. The abnormal and normal type of battery cells were acquired by online clustering strategy and bleeding circuits (R = 33 ohm were used to balance the abnormal cells. The simulation results showed that with the proposed balancing algorithm, the usable capacity of the battery pack increased by 0.614 Ah (9.5% compared to that without balancing.

  17. Redox homeostasis in stomach medium by foods: The Postprandial Oxidative Stress Index (POSI for balancing nutrition and human health

    Directory of Open Access Journals (Sweden)

    Joseph Kanner

    2017-08-01

    Full Text Available Red-meat lipid peroxidation in the stomach results in postprandial oxidative stress (POS which is characterized by the generation of a variety of reactive cytotoxic aldehydes including malondialdehyde (MDA. MDA is absorbed in the blood system reacts with cell proteins to form adducts resulting in advanced lipid peroxidation end products (ALEs, producing dysfunctional proteins and cellular responses. The pathological consequences of ALEs tissue damage include inflammation and increased risk for many chronic diseases that are associated with a Western-type diet. In earlier studies we used the simulated gastric fluid (SGF condition to show that the in vitro generation of MDA from red meat closely resembles that in human blood after consumption the same amount of meat. In vivo and in vitro MDA generations were similarly suppressed by polyphenol-rich beverages (red wine and coffee consumed with the meal. The present study uses the in vitro SGF to assess the capacity of more than 50 foods of plant origin to suppress red meat peroxidation and formation of MDA. The results were calculated as reducing POS index (rPOSI which represents the capacity in percent of 100 g of the food used to inhibit lipid peroxidation of 200 g red-meat a POSI enhancer (ePOSI. The index permitted to extrapolate the need of rPOSI from a food alone or in ensemble such Greek salad, to neutralize an ePOSI in stomach medium, (ePOS–rPOSI=0. The correlation between the rPOSI and polyphenols in the tested foods was R2=0.75. The Index was validated by comparison of the predicted rPOSI for a portion of Greek salad or red-wine to real inhibition of POS enhancers. The POS Index permit to better balancing nutrition for human health.

  18. Linking Economic Value Added, Direct Costing, and the Lean Thinking to the Balanced Scorecard in a System Dynamics Modelling Approach

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

     Purpose - To show how three practices normally applied separately can be linked to support the strategy evaluation and the performance measurement in the balanced scorecard. Recent studies, e.g. Kaplan and Norton [Using the Balanced Scorecard as a Strategic Management System, Harvard Business Re...

  19. Testing, adjusting and balancing for air distribution and hydronic circulation system of RIPF

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seon Duk; Bang, H. S

    2003-01-01

    This report is to perform T.A.B(Testing, Adjusting, and Balancing) for area of 7000 and 8000 zone in RIPF Building. According to code, standard and specification, T.A.B of air distribution and hydronic system are carried out and only written a general items. Owing to today's demanding the retrenchment in the energy, It is important that we perform our duties to test, adjust and balance air handle unit objectively and independently. Therefore, though the scientific and reasonable verification procedure, we must try to not only admit T.A.B. techniques which present societies demand, but also secure advanced technologies by means of accelerating the related techniques.

  20. Center of Gravity Compensation for Dynamically-Balanced Two-Wheeled Wheelchair System

    Science.gov (United States)

    Acar, Cihan; Murakami, Toshiyuki

    Two-wheeled systems have many advantages compared to statically stable systems. This paper describes a control strategy of dynamically-balanced two-wheeled wheelchair system that does not have any front casters. In this system, rider can sit the seat and control the motion of the system by adjusting CoG of his/her body. Unlike other commercial two-wheeled systems, CoG position of the upper body is mainly determined by the position of the user. Thus, there is a possibility that CoG position may not overlap with the wheel axis. In that case, sensor information cannot be used to measure the exact position of the CoG. This paper shows an estimation of method of the unknown CoG position for Two-Wheeled Dynamically-Balanced Wheelchair (TWDBW) is considered. Gravity torque observer with a compliance control is utilized to realize stable compensation according to the variable CoG position. Backstepping based nonlinear control design is applied to regulate and track the CoG motion of the upper body in the TWDBW. The validity of proposed method is verified by simulation and experimental results.

  1. Fuzzy coordinator compensation for balancing control of cart-seesaw system

    Science.gov (United States)

    Lin, J.; Guo, S.-Y.; Chang, Julian

    2011-12-01

    In contrast with fully controllable systems, a super articulated mechanical system (SAMS) is a controlled underactuated mechanical system in which the dimensions of the configuration space exceed the dimensions of the control input space. The control of the cart-seesaw system is especially difficult since it is an underactuated mechanism (three degrees of freedom and only two inputs). This research develops a balancing approach for a novel SAMS model, called the cart-seesaw system, using fuzzy logic and fuzzy coordinator compensation to drive the sliding carts and keep the seesaw angle close to zero in the equilibrium state. Experimental results indicate that utilizing the proposed control methodology significantly enhances the performance. Moreover, the presentation of the fuzzy balancing controller is not considerably affected by changes in the environmental parameters, which demonstrates the effectiveness of the fuzzy controller in minimizing the seesaw tilt angle in the time domain, although the system is caused by unpredicted loading variation. Moreover, the experimental results indicate the usefulness and robustness of the proposed fuzzy control methodology. Furthermore, the proposed software/hardware platform can be beneficial for standardizing laboratory equipment and developing amusement apparatus.

  2. Dynamic and balanced capacity allocation scheme with uniform bandwidth for OFDM-PON systems

    Science.gov (United States)

    Lei, Cheng; Chen, Hongwei; Chen, Minghua; Yu, Ying; Guo, Qiang; Yang, Sigang; Xie, Shizhong

    2015-03-01

    As the bitrate of orthogonal frequency division multiplexing passive optical network (OFDM-PON) system is continuously increasing, how to effectively allocate the system bandwidth among the huge number of optical network units (ONUs) is one of the key problems before OFDM-PON can be practical deployed. Unlike traditional bandwidth allocation scheme, in this paper, the transmission performance of single ONU is for the first time taken into consideration and optimized. To reduce the manufacturing complexity and fully utilize the processing ability of the receivers, the system bandwidth is equally distributed to the ONUs. Bit loading is used to allocate the total transmission capacity, and power loading is used to guarantee the ONUs have balanced transmission performance even if they operate at different bitrate. In this way, a dynamic and balanced capacity allocation scheme with uniform bandwidth for OFDM-PON systems can be realized. At last, an experimental system is established to verify the feasibility of the proposed scheme, and the influence that the scheme brings to the whole system is also analyzed.

  3. System of Thermal Balance Maintenance in Modern Test Benches for Centrifugal Pumps

    Directory of Open Access Journals (Sweden)

    A. I. Petrov

    2015-01-01

    Full Text Available The article “Systems of the heat balance maintenance in modern test benches for centrifugal pumps” makes the case to include cooling systems of a working fluid (heat setting in test bench for impeller pumps. It briefly summarizes an experience of bench building to test centrifugal pumps, developed at the BMSTU Department E-10 over the last 10 years. The article gives the formulas and the algorithm to calculate the heat capacity of different types of impeller pumps when tested at the bench as ell as to determine the heating time of the liquid in the bench without external cooling. Based on analysis of the power balance of a centrifugal pump, it is shown that about 90% of the pump unit-consumed electric power in terminals is used for heating up the working fluid in the loop of the test bench. The article gives examples of elementary heat calculation of the pump operation within the test bench. It presents the main types of systems to maintain thermal balance, their advantages, disadvantages and possible applications. The cooling system schemes for open and closed version of the benches both with built-in and with an independent cooling circuit are analysed. The paper separately considers options of such systems for large benches using the cooling tower as a cooling device in the loop, and to test the pumps using the hydraulic fluids other than water, including those at high temperatures of working fluids; in the latter case a diagram of dual-circuit cooling system "liquid-liquid-air" is shown. The paper depicts a necessity to use ethylene glycol coolant in the two-loop cooling bench. It provides an example of combining the functions of cooling and filtration in a single cooling circuit. Criteria for effectiveness of these systems are stated. Possible ways for developing systems to maintain a thermal balance, modern methods of regulation and control are described. In particular, the paper shows the efficiency of frequency control of the

  4. Constructing an Efficient and Balanced European Patent System: “Muddling through”

    DEFF Research Database (Denmark)

    Schovsbo, Jens Hemmingsen

    2011-01-01

    The paper discusses ways to construct a more efficient and balanced European patent system. It identifies and describes challenges relating to innovation, to non-economic issues and to governance. In order to improve the patent system, a cautious approach of “Muddling through” is recommended. More...... concretely, the paper puts forward some of the solutions proposed in the STOA Report to the European Parliament on “Policy options for the improvement of the European patent system” and suggest initiatives such as the insertion of a mission statement in the EPC, improvement of patent quality, increasing...... access to patented inventions and enhancement of governance....

  5. Discussing Feedback System Thinking in Relation to a Balanced Scorecard, Inspired by an Actual Case

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

    Since the emergence of the Balanced Scorecard at the beginning of the 1990s, only few articles have proposed a framework of translating BSC into an analytical numerical model. This paper addresses two research themes : (1) a discussion of the cause-and-effect modeling within the BSC and (2), how...... may the feedback systems thinking and causal loop reasoning be conducted within BSC. In contrast to previous literature on BSC this paper focuses on a System Dynamics Modeling approach to transform a static BSC into a dynamic and analytical closed loop management model by incorporating both time...

  6. The Importance of the Ionic Product for Water to Understand the Physiology of the Acid-Base Balance in Humans

    OpenAIRE

    Adeva-Andany, María M.; Natalia Carneiro-Freire; Cristóbal Donapetry-García; Eva Rañal-Muíño; Yosua López-Pereiro

    2014-01-01

    Human plasma is an aqueous solution that has to abide by chemical rules such as the principle of electrical neutrality and the constancy of the ionic product for water. These rules define the acid-base balance in the human body. According to the electroneutrality principle, plasma has to be electrically neutral and the sum of its cations equals the sum of its anions. In addition, the ionic product for water has to be constant. Therefore, the plasma concentration of hydrogen ions depends on th...

  7. [Long-term effect of environmental cadmium exposure on human body's mineral metabolic balance].

    Science.gov (United States)

    Ling, H T; Huang, R; Liang, X X; Li, Z X; Wang, J; Tan, J B; Wu, S X; Wang, P; Chen, Z H; Huang, Q; Lyu, Y J; Jiang, Q; Yang, X F; Wu, Y N

    2016-04-01

    To investigate the effect of long-term exposure to environmental cadmium on eight mineral element's metabolic balance of human body. To choose a high cadmium area polluted by smelting and mining north of Guangdong province and a cadmium-free area with a similar economic level, and living and eating habit of residents as a contrast from April 2011 to August 2012. Stratified random sampling and clustered sampling method were adopted to choose the non-occupationally cadmium-exposed respondents who have lived in local area for more than 15 years, older than 40 years, having local rice and vegetable as the main dietary source, with simple and relatively stable diet, and without diabetes, kidney disease, thyroid disease, liver disease or other history of chronic disease. This study included 298 respondents, of whom 155 were in cadmium exposure group and 143 in control group. Questionnaires was used to acquire their health status and their morning urine samples were collected. Electrolytically coupled plasma mass spectrometry (ICP-MS) was used to test the concentrations of sodium(Na), magnesium (Mg), phosphorus (P), potassium (K), calcium (Ca), copper (Cu), zinc (Zn) and iodine (I). The Mann-Whitney U test method was used to compare the differences of concentrations of urinary cadmium, Na, Mg, P, K, Ca, Cu, Zn, I, and the ratio of Na to K (Na/K), Ca to P (Ca/P) between exposed group and control group.χ(2) test was used to compare the abnormal rate of urinary cadmium between exposed group and control group. Pearson correlation and multiple regression method were used to investigate the relationship between urinary cadmium levels, gender, age, smoking, passive smoking, and minerals. The urinary cadmium level P50 (P25-P75) in exposed group was 5.45 (2.62-10.68) μg/g·cr, which was higher than that of the control group, which was 1.69 (1.22-2.36) μg/g·cr (Z=-10.49,Phuman body.

  8. Regional Balance Model of Financial Flows through Sectoral Approaches System of National Accounts

    Directory of Open Access Journals (Sweden)

    Ekaterina Aleksandrovna Zaharchuk

    2017-03-01

    Full Text Available The main purpose of the study, the results of which are reflected in this article, is the theoretical and methodological substantiation of possibilities to build a regional balance model of financial flows consistent with the principles of the construction of the System of National Accounts (SNA. The paper summarizes the international experience of building regional accounts in the SNA as well as reflects the advantages and disadvantages of the existing techniques for constructing Social Accounting Matrix. The authors have proposed an approach to build the regional balance model of financial flows, which is based on the disaggregated tables of the formation, distribution and use of the added value of territory in the framework of institutional sectors of SNA (corporations, public administration, households. Within the problem resolution of the transition of value added from industries to sectors, the authors have offered an approach to the accounting of development, distribution and use of value added within the institutional sectors of the territories. The methods of calculation are based on the publicly available information base of statistics agencies and federal services. The authors provide the scheme of the interrelations of the indicators of the regional balance model of financial flows. It allows to coordinate mutually the movement of regional resources by the sectors of «corporation», «public administration» and «households» among themselves, and cash flows of the region — by the sectors and directions of use. As a result, they form a single account of the formation and distribution of territorial financial resources, which is a regional balance model of financial flows. This matrix shows the distribution of financial resources by income sources and sectors, where the components of the formation (compensation, taxes and gross profit, distribution (transfers and payments and use (final consumption, accumulation of value added are

  9. Estimation of Optimum Stimulus Amplitude for Balance Training using Electrical Stimulation of the Vestibular System

    Science.gov (United States)

    Goel, R.; Rosenberg, M. J.; De Dios, Y. E.; Cohen, H. S.; Bloomberg, J. J.; Mulavara, A. P.

    2016-01-01

    Sensorimotor changes such as posture and gait instabilities can affect the functional performance of astronauts after gravitational transitions. Sensorimotor Adaptability (SA) training can help alleviate decrements on exposure to novel sensorimotor environments based on the concept of 'learning to learn' by exposure to varying sensory challenges during posture and locomotion tasks (Bloomberg 2015). Supra-threshold Stochastic Vestibular Stimulation (SVS) can be used to provide one of many challenges by disrupting vestibular inputs. In this scenario, the central nervous system can be trained to utilize veridical information from other sensory inputs, such as vision and somatosensory inputs, for posture and locomotion control. The minimum amplitude of SVS to simulate the effect of deterioration in vestibular inputs for preflight training or for evaluating vestibular contribution in functional tests in general, however, has not yet been identified. Few studies (MacDougall 2006; Dilda 2014) have used arbitrary but fixed maximum current amplitudes from 3 to 5 mA in the medio-lateral (ML) direction to disrupt balance function in healthy adults. Giving this high level of current amplitude to all the individuals has a risk of invoking side effects such as nausea and discomfort. The goal of this study was to determine the minimum SVS level that yields an equivalently degraded balance performance. Thirteen subjects stood on a compliant foam surface with their eyes closed and were instructed to maintain a stable upright stance. Measures of stability of the head, trunk, and whole body were quantified in the ML direction. Duration of time they could stand on the foam surface was also measured. The minimum SVS dosage was defined to be that level which significantly degraded balance performance such that any further increase in stimulation level did not lead to further balance degradation. The minimum SVS level was determined by performing linear fits on the performance variable

  10. Multicompartment ecosystem mass balances as a tool for understanding and managing the biogeochemical cycles of human ecosystems.

    Science.gov (United States)

    Baker, L A; Hope, D; Xu, Y; Edmonds, J

    2001-10-09

    Nitrogen remains a ubiquitous pollutant in surface and groundwater throughout the United States, despite 30 years of pollution control efforts. A detailed multicompartment N balance for the Central Arizona-Phoenix ecosystem is used to illustrate how an ecosystem-level approach can be used to develop improved N management strategies. The N balance is used to demonstrate how nitrate in pumped groundwater used for crop irrigation could be used to reduce inputs of commercial fertilizer and decrease N leaching to aquifers. Effectively managing N pollution also will require an understanding of the complex factors that control the N balance, including targeted regulations, individual human behavior, land-use conversion, and other ecosystem management practices that affect the N balance. These sometimes countervailing factors are illustrated with several scenarios of wastewater treatment technology and population growth in the Phoenix area. Management of N eventually must be coupled to management of other elements, notably carbon, phosphorus, and salts. We postulate that an ecosystem framework for pollution management will result in strategies that are more effective, fairer, and less expensive than current approaches.

  11. Surface N Balances in Agricultural Crop Production Systems in China for the Period 1980-2015

    Institute of Scientific and Technical Information of China (English)

    SUN Bo; SHEN Run-Ping; A.F.BOUWMAN

    2008-01-01

    Surface nitrogen (N) balances for ChinEs crop production systems was estimated using statistical data collected from 1980 to 2004 at the national and provincial scale and from 1994 to 1999 at the county level.There was a surplus N balance throughout these periods,but the surplus was nearly stable in recent years.Projections using nonseasonal Box-Jenkins model or exponential models show that the N surplus for the total cultivated land in China was likely to increase from 142.8 kg ha-1 in 2004 to 168.6 kg ha-1 in 2015.The N balance surplus in the more developed southeastern provinces was the largest,and was slightly less in the central region,which caused the nitrate pollution in the ground water.The N surplus was much less in the western and northern provinces because of lower synthetic fertilizer inputs.The region with high N risk includes Beijing Municipality and Jiangsu,Zhejiang,Fujian,Guangdong,Hubei,and Shandong provinces for 2002-2004.The projections suggested that 15 provinces (or municipalities) in the middle and southeastern part of China except Jiangxi and Shanxi provinces would become the high-risk region by 2015.The level of economic development,transportation,and labor force condition had an important effect on the N balance surplus at the county level,but the last two factors showed remarkable impact at the provincial level.To decrease the nonpoint pollution (Npp) risk from crop production,the authors suggested to reduce the target level for national grain self-sufficiency to 90%-95% and change the regional structure of grain production by moving some of the future grain production from the high Npp risk areas of eastern China to parts of the central and western provinces where the Npp risk was much less.

  12. Steam System Balancing and Tuning for Multifamily Residential Buildings in Chicagoland - Second Year of Data Collection

    Energy Technology Data Exchange (ETDEWEB)

    Choi, J.; Ludwig, P.; Brand, L.

    2013-08-01

    Steam heated buildings often suffer from uneven heating as a result of poor control of the amount of steam entering each radiator. In order to satisfy the heating load to the coldest units, other units are overheated. As a result, some tenants complain of being too hot and open their windows in the middle of winter, while others complain of being too cold and are compelled to use supplemental heat sources. Building on previous research, CNT Energy identified 10 test buildings in Chicago and conducted a study to identify best practices for the methodology, typical costs, and energy savings associated with steam system balancing. A package of common steam balancing measures was assembled and data were collected on the buildings before and after these retrofits were installed to investigate the process, challenges, and the cost effectiveness of improving steam systems through improved venting and control systems. The test buildings that received venting upgrades and new control systems showed 10.2% savings on their natural gas heating load, with a simple payback of 5.1 years. The methodologies for and findings from this study are presented in detail in this report. This report has been updated from a version published in August 2012 to include natural gas usage information from the 2012 heating season and updated natural gas savings calculations.

  13. An estimation of the water balance in a reformer/fuel-cells system

    Energy Technology Data Exchange (ETDEWEB)

    Jovan, Vladimir [Jo-ef Stefan Institute and Centre of Excellence Low-Carbon Technologies (Slovenia); Cufar, Alja [University of Ljubljana, Faculty of Mathematics and Physics (Slovenia)], e-mail: vladimir.jovan@ijs.si

    2011-07-01

    PEM fuel cells use hydrogen as fuel. Since it is a very light element, its energy density is small despite its high caloric value. Thus hydrogen storage requires a lot of space. One possible solution is simultaneous production of hydrogen from higher-density materials, such as methanol. The object of this paper is to determine what is the total water balance in a system consisting of a methanol reformer and a fuel-cells-based generator set, and to determine if water should be supplied to, or removed from, the system. Based on relatively little information obtained from technical sources and on some simple assumptions, this paper presents a model which helps to determine the actual water balance in the system. In conclusion, commercially available fuel-cell systems with realistic water production can be used for fuel reforming purposes in the methanol reformer. It is also shown that under normal operating conditions, and using commercially available devices, there is always an excess of water produced.

  14. The Demand Side Management Potential to Balance a Highly Renewable European Power System

    Directory of Open Access Journals (Sweden)

    Alexander Kies

    2016-11-01

    Full Text Available Shares of renewables continue to grow in the European power system. A fully renewable European power system will primarily depend on the renewable power sources of wind and photovoltaics (PV, which are not dispatchable but intermittent and therefore pose a challenge to the balancing of the power system. To overcome this issue, several solutions have been proposed and investigated in the past, including storage, backup power, reinforcement of the transmission grid, and demand side management (DSM. In this paper, we investigate the potential of DSM to balance a simplified, fully renewable European power system. For this purpose, we use ten years of weather and historical load data, a power-flow model and the implementation of demand side management as a storage equivalent, to investigate the impact of DSM on the need for backup energy. We show that DSM has the potential to reduce the need for backup energy in Europe by up to one third and can cover the need for backup up to a renewable share of 67%. Finally, it is demonstrated that the optimal mix of wind and PV is shifted by the utilisation of DSM towards a higher share of PV, from 19% to 36%.

  15. A new accounting system for financial balance based on personnel cost after the introduction of a DPC/DRG system.

    Science.gov (United States)

    Nakagawa, Yoshiaki; Takemura, Tadamasa; Yoshihara, Hiroyuki; Nakagawa, Yoshinobu

    2011-04-01

    A hospital director must estimate the revenues and expenses not only in a hospital but also in each clinical division to determine the proper management strategy. A new prospective payment system based on the Diagnosis Procedure Combination (DPC/PPS) introduced in 2003 has made the attribution of revenues and expenses for each clinical department very complicated because of the intricate involvement between the overall or blanket component and a fee-for service (FFS). Few reports have so far presented a programmatic method for the calculation of medical costs and financial balance. A simple method has been devised, based on personnel cost, for calculating medical costs and financial balance. Using this method, one individual was able to complete the calculations for a hospital which contains 535 beds and 16 clinics, without using the central hospital computer system.

  16. A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans.

    Science.gov (United States)

    Spector, Reynold; Robert Snodgrass, S; Johanson, Conrad E

    2015-11-01

    In this review, a companion piece to our recent examination of choroid plexus (CP), the organ that secretes the cerebrospinal fluid (CSF), we focus on recent information in the context of reliable older data concerning the composition and functions of adult human CSF. To accomplish this, we define CSF, examine the methodology employed in studying the CSF focusing on ideal or near ideal experiments and discuss the pros and cons of several widely used analogical descriptions of the CSF including: the CSF as the "third circulation," the CSF as a "nourishing liquor," the similarities of the CSF/choroid plexus to the glomerular filtrate/kidney and finally the CSF circulation as part of the "glymphatic system." We also consider the close interrelationship between the CSF and extracellular space of brain through gap junctions and the paucity of data suggesting that the cerebral capillaries secrete a CSF-like fluid. Recently human CSF has been shown to be in dynamic flux with heart-beat, posture and especially respiration. Functionally, the CSF provides buoyancy, nourishment (e.g., vitamins) and endogenous waste product removal for the brain by bulk flow into the venous (arachnoid villi and nerve roots) and lymphatic (nasal) systems, and by carrier-mediated reabsorptive transport systems in CP. The CSF also presents many exogenous compounds to CP for metabolism or removal, indirectly cleansing the extracellular space of brain (e.g., of xenobiotics like penicillin). The CSF also carries hormones (e.g., leptin) from blood via CP or synthesized in CP (e.g., IGF-2) to the brain. In summary the CP/CSF, the third circulation, performs many functions comparable to the kidney including nourishing the brain and contributing to a stable internal milieu for the brain. These tasks are essential to normal adult brain functioning.

  17. The circadian system and the balance of the autonomic nervous system.

    Science.gov (United States)

    Buijs, Ruud M; Escobar, Carolina; Swaab, Dick F

    2013-01-01

    Our biological clock, the suprachiasmatic nucleus (SCN), sets the pace of our life: it provides a rhythmic function to our sleep-wake cycle. In order to do so properly the SCN synchronizes our physiology to behavioral patterns by directing the autonomic and hormonal output of the hypothalamus to the different organs of the body that require a different setting - activity or inactivity - during particular phases of the day or night. In this chapter we show that this delicate balance requires that the SCN should not only provide an output to these organs but also be informed about the physiological state of the organs in order to adapt its output. This occurs via a hypothalamic neuronal network that provides the necessary input to the SCN. We argue that the feedback that the SCN receives from its hypothalamic target structures is essential to maintain a balance in our physiological functions, which fluctuate during the sleep-wake cycle. We propose that this crucial role of the hypothalamus in the homeostatic response is the reason why, e.g., in aging or depression, changes in the functioning of the biological clock, the SCN, lead to the development of pathology. In addition, if this balance is not adequately organized, for example, if the signals of the biological clock are violated by being active and eating during the night, as in shift work, one will be more susceptible to diseases such as hypertension, obesity, diabetes, and metabolic syndrome.

  18. Fuzzy droop control loops adjustment for stored energy balance in distributed energy storage system

    DEFF Research Database (Denmark)

    Aldana, Nelson Leonardo Diaz; Wu, Dan; Dragicevic, Tomislav;

    2015-01-01

    The study of isolated AC microgrid has been under high interest due to the integration of renewable energy resources especially for remote areas, or to improve the local energy reliability. The current trend is oriented to distributed renewable energy sources and their corresponding energy storage...... system, in order to smooth the variations at the prime energy generator. In this paper, a decentralized strategy based on fuzzy logic is proposed in order to balance the state of charge of distributed energy storage systems in lowvoltage three phase AC microgrid. The proposed method weights the action...... of conventional droop control loops for battery based distributed energy storage systems, in order to equalize their stored energy. The units are selfcontrolled by using local variables, hence, the microgrid can operate without communication systems. Frequency and voltage bus signaling are used in order...

  19. Vibration analysis of nonlinear systems with the bilinear hysteretic oscillator by using incremental harmonic balance method

    Science.gov (United States)

    Xiong, Huai; Kong, Xianren; Li, Haiqin; Yang, Zhenguo

    2017-01-01

    This paper considers dynamics of bilinear hysteretic systems, which are widely used for vibration control and vibration absorption such as magneto-rheological damper, metal-rubber. The method of incremental harmonic balance (IHB) technique that hysteresis is considered in the corrective term is improved in order to determine periodic solutions of bilinear hysteretic systems. The improved continuation method called two points tracing algorithm which is stable to the turning point makes the calculation more efficient for tracing amplitude-frequency response. Precise Hsu's method for analysing the stability of periodic solutions is introduced. The effects of different parameters of bilinear hysteretic oscillator on the response are discussed numerically. Some numerical simulations of considered bilinear hysteretic systems, including a single DOF and a 2DOF system, are effectively obtained by the modified IHB method and the results compare very well with the 4-oder Runge-Kutta method.

  20. Real-time impact of power balancing on power system operation with large scale integration of wind power

    DEFF Research Database (Denmark)

    Basit, Abdul; Hansen, Anca Daniela; Sørensen, Poul Ejnar

    2016-01-01

    Highly wind power integrated power system requires continuous active power regulation to tackle the power imbalances resulting from the wind power forecast errors. The active power balance is maintained in real-time with the automatic generation control and also from the control room, where...... regulating power bids are activated manually. In this article, an algorithm is developed to simulate the activation of regulating power bids, as performed in the control room, during power imbalance between generation and load demand. In addition, the active power balance is also controlled through automatic...... power system model. The power system model takes the hour-ahead regulating power plan from power balancing model and the generation and power exchange capacities for the year 2020 into account. The real-time impact of power balancing in a highly wind power integrated power system is assessed...

  1. The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

    NARCIS (Netherlands)

    Redin, Claire; Brand, Harrison; Collins, Ryan L; Kammin, Tammy; Mitchell, Elyse; Hodge, Jennelle C; Hanscom, Carrie; Pillalamarri, Vamsee; Seabra, Catarina M; Abbott, Mary-Alice; Abdul-Rahman, Omar A; Aberg, Erika; Adley, Rhett; Alcaraz-Estrada, Sofia L; Alkuraya, Fowzan S; An, Yu; Anderson, Mary-Anne; Antolik, Caroline; Anyane-Yeboa, Kwame; Atkin, Joan F; Bartell, Tina; Bernstein, Jonathan A; Beyer, Elizabeth; Blumenthal, Ian; Bongers, Ernie M H F; Brilstra, Eva H|info:eu-repo/dai/nl/23639195X; Brown, Chester W; Brüggenwirth, Hennie T; Callewaert, Bert; Chiang, Colby; Corning, Ken; Cox, Helen; Cuppen, Edwin|info:eu-repo/dai/nl/183050487; Currall, Benjamin B; Cushing, Tom; David, Dezso; Deardorff, Matthew A; Dheedene, Annelies; D'Hooghe, Marc; de Vries, Bert B A; Earl, Dawn L; Ferguson, Heather L; Fisher, Heather; FitzPatrick, David R; Gerrol, Pamela; Giachino, Daniela; Glessner, Joseph T; Gliem, Troy; Grady, Margo; Graham, Brett H; Griffis, Cristin; Gripp, Karen W; Gropman, Andrea L; Hanson-Kahn, Andrea; Harris, David J; Hayden, Mark A; Hill, Rosamund; Hochstenbach, Ron|info:eu-repo/dai/nl/117339067; Hoffman, Jodi D; Hopkin, Robert J; Hubshman, Monika W; Innes, A Micheil; Irons, Mira; Irving, Melita; Jacobsen, Jessie C; Janssens, Sandra; Jewett, Tamison; Johnson, John P; Jongmans, Marjolijn C; Kahler, Stephen G; Koolen, David A; Korzelius, Jerome; Kroisel, Peter M; Lacassie, Yves; Lawless, William; Lemyre, Emmanuelle; Leppig, Kathleen; Levin, Alex V; Li, Haibo; Li, Hong; Liao, Eric C; Lim, Cynthia; Lose, Edward J; Lucente, Diane; Macera, Michael J; Manavalan, Poornima; Mandrile, Giorgia; Marcelis, Carlo L; Margolin, Lauren; Mason, Tamara; Masser-Frye, Diane; McClellan, Michael W; Mendoza, Cinthya J Zepeda; Menten, Björn; Middelkamp, Sjors; Mikami, Liya R; Moe, Emily; Mohammed, Shehla; Mononen, Tarja; Mortenson, Megan E; Moya, Graciela; Nieuwint, Aggie W; Ordulu, Zehra; Parkash, Sandhya; Pauker, Susan P; Pereira, Shahrin; Perrin, Danielle; Phelan, Katy; Aguilar, Raul E Piña; Poddighe, Pino J; Pregno, Giulia; Raskin, Salmo; Reis, Linda; Rhead, William; Rita, Debra; Renkens, Ivo; Roelens, Filip; Ruliera, Jayla; Rump, Patrick; Schilit, Samantha L P; Shaheen, Ranad; Sparkes, Rebecca; Spiegel, Erica; Stevens, Blair; Stone, Matthew R; Tagoe, Julia; Thakuria, Joseph V; van Bon, Bregje W; van de Kamp, Jiddeke; van Der Burgt, Ineke; van Essen, Ton; van Ravenswaaij-Arts, Conny M; van Roosmalen, Markus J; Vergult, Sarah; Volker-Touw, Catharina M L; Warburton, Dorothy P; Waterman, Matthew J; Wiley, Susan; Wilson, Anna; Yerena-de Vega, Maria de la Concepcion A; Zori, Roberto T; Levy, Brynn; Brunner, Han G; de Leeuw, Nicole; Kloosterman, Wigard P|info:eu-repo/dai/nl/304076953; Thorland, Erik C; Morton, Cynthia C; Gusella, James F; Talkowski, Michael E

    2017-01-01

    Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing re

  2. The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

    NARCIS (Netherlands)

    Redin, Claire; Brand, Harrison; Collins, Ryan L.; Kammin, Tammy; Mitchell, Elyse; Hodge, Jennelle C.; Hanscom, Carrie; Pillalamarri, Vamsee; Seabra, Catarina M.; Abbott, Mary-Alice; Abdul-Rahman, Omar A.; Aberg, Erika; Adley, Rhett; Alcaraz-Estrada, Sofia L.; Alkuraya, Fowzan S.; An, Yu; Anderson, Mary-Anne; Antolik, Caroline; Anyane-Yeboa, Kwame; Atkin, Joan F.; Bartell, Tina; Bernstein, Jonathan A.; Beyer, Elizabeth; Blumenthal, Ian; Bongers, Ernie M. H. F.; Brilstra, Eva H.; Brown, Chester W.; Bruggenwirth, Hennie T.; Callewaert, Bert; Chiang, Colby; Corning, Ken; Cox, Helen; Cuppen, Edwin; Currall, Benjamin B.; Cushing, Tom; David, Dezso; Deardorff, Matthew A.; Dheedene, Annelies; D'Hooghe, Marc; de Vries, Bert B. A.; Earl, Dawn L.; Ferguson, Heather L.; Fisher, Heather; FitzPatrick, David R.; Gerrol, Pamela; Giachino, Daniela; Glessner, Joseph T.; Gliem, Troy; Grady, Margo; Graham, Brett H.; Griffis, Cristin; Gripp, Karen W.; Gropman, Andrea L.; Hanson-Kahn, Andrea; Harris, David J.; Hayden, Mark A.; Hill, Rosamund; Hochstenbach, Ron; Hoffman, Jodi D.; Hopkin, Robert J.; Hubshman, Monika W.; Innes, A. Micheil; Irons, Mira; Irving, Melita; Jacobsen, Jessie C.; Janssens, Sandra; Jewett, Tamison; Johnson, John P.; Jongmans, Marjolijn C.; Kahler, Stephen G.; Koolen, David A.; Korzelius, Jerome; Kroisel, Peter M.; Lacassie, Yves; Lawless, William; Lemyre, Emmanuelle; Leppig, Kathleen; Levin, Alex V.; Li, Haibo; Li, Hong; Liao, Eric C.; Lim, Cynthia; Lose, Edward J.; Lucente, Diane; Macera, Michael J.; Manavalan, Poornima; Mandrile, Giorgia; Marcelis, Carlo L.; Margolin, Lauren; Mason, Tamara; Masser-Frye, Diane; McClellan, Michael W.; Mendoza, Cinthya J. Zepeda; Menten, Bjorn; Middelkamp, Sjors; Mikami, Liya R.; Moe, Emily; Mohammed, Shehla; Mononen, Tarja; Mortenson, Megan E.; Moya, Graciela; Nieuwint, Aggie W.; Ordulu, Zehra; Parkash, Sandhya; Pauker, Susan P.; Pereira, Shahrin; Perrin, Danielle; Phelan, Katy; Pina Aguilar, Raul E.; Poddighe, Pino J.; Pregno, Giulia; Raskin, Salmo; Reis, Linda; Rhead, William; Rita, Debra; Renkens, Ivo; Roelens, Filip; Ruliera, Jayla; Rump, Patrick; Schilit, Samantha L. P.; Shaheen, Ranad; Sparkes, Rebecca; Spiegel, Erica; Stevens, Blair; Stone, Matthew R.; Tagoe, Julia; Thakuria, Joseph V.; van Bon, Bregje W.; van de Kamp, Jiddeke; van Der Burgt, Ineke; van Essen, Ton; van Ravenswaaij-Arts, Conny M.; van Roosmalen, Markus J.; Vergult, Sarah; Volker-Touw, Catharina M. L.; Warburton, Dorothy P.; Waterman, Matthew J.; Wiley, Susan; Wilson, Anna; Yerena-de Vega, Maria de la Concepcion A.; Zori, Roberto T.; Levy, Brynn; Brunner, Han G.; de Leeuw, Nicole; Kloosterman, Wigard P.; Thorland, Erik C.; Morton, Cynthia C.; Gusella, James F.; Talkowski, Michael E.

    2017-01-01

    Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing re

  3. The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

    NARCIS (Netherlands)

    Redin, Claire; Brand, Harrison; Collins, Ryan L; Kammin, Tammy; Mitchell, Elyse; Hodge, Jennelle C; Hanscom, Carrie; Pillalamarri, Vamsee; Seabra, Catarina M; Abbott, Mary-Alice; Abdul-Rahman, Omar A; Aberg, Erika; Adley, Rhett; Alcaraz-Estrada, Sofia L; Alkuraya, Fowzan S; An, Yu; Anderson, Mary-Anne; Antolik, Caroline; Anyane-Yeboa, Kwame; Atkin, Joan F; Bartell, Tina; Bernstein, Jonathan A; Beyer, Elizabeth; Blumenthal, Ian; Bongers, Ernie M H F; Brilstra, Eva H; Brown, Chester W; Brüggenwirth, Hennie T; Callewaert, Bert; Chiang, Colby; Corning, Ken; Cox, Helen; Cuppen, Edwin; Currall, Benjamin B; Cushing, Tom; David, Dezso; Deardorff, Matthew A; Dheedene, Annelies; D'Hooghe, Marc; de Vries, Bert B A; Earl, Dawn L; Ferguson, Heather L; Fisher, Heather; FitzPatrick, David R; Gerrol, Pamela; Giachino, Daniela; Glessner, Joseph T; Gliem, Troy; Grady, Margo; Graham, Brett H; Griffis, Cristin; Gripp, Karen W; Gropman, Andrea L; Hanson-Kahn, Andrea; Harris, David J; Hayden, Mark A; Hill, Rosamund; Hochstenbach, Ron; Hoffman, Jodi D; Hopkin, Robert J; Hubshman, Monika W; Innes, A Micheil; Irons, Mira; Irving, Melita; Jacobsen, Jessie C; Janssens, Sandra; Jewett, Tamison; Johnson, John P; Jongmans, Marjolijn C; Kahler, Stephen G; Koolen, David A; Korzelius, Jerome; Kroisel, Peter M; Lacassie, Yves; Lawless, William; Lemyre, Emmanuelle; Leppig, Kathleen; Levin, Alex V; Li, Haibo; Li, Hong; Liao, Eric C; Lim, Cynthia; Lose, Edward J; Lucente, Diane; Macera, Michael J; Manavalan, Poornima; Mandrile, Giorgia; Marcelis, Carlo L; Margolin, Lauren; Mason, Tamara; Masser-Frye, Diane; McClellan, Michael W; Mendoza, Cinthya J Zepeda; Menten, Björn; Middelkamp, Sjors; Mikami, Liya R; Moe, Emily; Mohammed, Shehla; Mononen, Tarja; Mortenson, Megan E; Moya, Graciela; Nieuwint, Aggie W; Ordulu, Zehra; Parkash, Sandhya; Pauker, Susan P; Pereira, Shahrin; Perrin, Danielle; Phelan, Katy; Aguilar, Raul E Piña; Poddighe, Pino J; Pregno, Giulia; Raskin, Salmo; Reis, Linda; Rhead, William; Rita, Debra; Renkens, Ivo; Roelens, Filip; Ruliera, Jayla; Rump, Patrick; Schilit, Samantha L P; Shaheen, Ranad; Sparkes, Rebecca; Spiegel, Erica; Stevens, Blair; Stone, Matthew R; Tagoe, Julia; Thakuria, Joseph V; van Bon, Bregje W; van de Kamp, Jiddeke; van Der Burgt, Ineke; van Essen, Ton; van Ravenswaaij-Arts, Conny M; van Roosmalen, Markus J; Vergult, Sarah; Volker-Touw, Catharina M L; Warburton, Dorothy P; Waterman, Matthew J; Wiley, Susan; Wilson, Anna; Yerena-de Vega, Maria de la Concepcion A; Zori, Roberto T; Levy, Brynn; Brunner, Han G; de Leeuw, Nicole; Kloosterman, Wigard P; Thorland, Erik C; Morton, Cynthia C; Gusella, James F; Talkowski, Michael E

    2016-01-01

    Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing re

  4. A forecast of new test capabilities using Magnetic Suspension and Balance Systems

    Science.gov (United States)

    Lawing, Pierce L.; Johnson, William G., Jr.

    1988-01-01

    This paper outlines the potential of Magnetic Suspension and Balance System (MSBS) technology to solve existing problems related to support interference in wind tunnels. Improvement of existing test techniques and exciting new techniques are envisioned as a result of applying MSBS. These include improved data accuracy, dynamic stability testing, two-body/stores release testing, and pilot/designer-in-the-loop tests. It also discusses the use of MSBS for testing exotic configurations such as hybrid hypersonic vehicles. A new facility concept that combines features of ballistic tubes, magnetic suspension, and cryogenic tunnels is described.

  5. A new metal detection method based on balanced coil for mobile phone wireless charging system

    Science.gov (United States)

    Zhou, B.; Liu, Z. Z.; Chen, H. X.; Zeng, H.; Hei, T.

    2016-08-01

    The wireless charging time of mobile phone will increase greatly if the metal objects mix in the magnetic field coupling area. In addition, the fire may be caused as for the high temperature of metal objects. The paper proposed an improved detecting method based on balance coil for mobile phone wireless charging system according to comparing the advantages and disadvantages of traditional metal detection methods. The circuit model was established, and hardware and software were optimized. At last, experimental results verified the theoretical analysis.

  6. Formative Classroom Assessment and Large-Scale Assessment: Toward a More Balanced System

    Directory of Open Access Journals (Sweden)

    Felipe Martínez Rizo

    2009-11-01

    Full Text Available Given the proliferation of large-scale standardized tests that has occurred in Mexico in recent years, this article constitutes a review of the international literature on the subject for the purpose of reflecting on the possible consequences of this phenomenon and exploring the progress of alternative assessment approaches. It also reviews the development of concepts related to formative classroom assessment, and summarizes current thinking on this subject. It emphasizes the importance of such approaches for improving educational quality. In conclusion, it argues that it is necessary to move toward assessment systems that combine large-scale assessment and classroom assessment in a more balanced fashion.

  7. Self-organizing method for collaboration in multi-robot system on basis of balance principle

    Institute of Scientific and Technical Information of China (English)

    Yangbin DONA; Jinping JIANG; Yan HE

    2008-01-01

    By analyzing the operation characteristics of two subtasks that have resource dependency on each other, this paper demonstrates the impact of progress relation between the two subtasks on the whole task's progress, and then puts forward a self-organizing prin-ciple called balance principle that keeps the individual profit between robots equal. Furthermore, an algorithm is designed for adjusting subtask selection on the basis of this principle. Simulation shows the validity of the algorithm on self-organizing task allocation in a multi-robot system.

  8. Battery system and method for sensing and balancing the charge state of battery cells

    Science.gov (United States)

    Davies, Francis J. (Inventor)

    2012-01-01

    A battery system utilizes a plurality of transformers interconnected with the battery cells. The transformers each have at least one transformer core operable for magnetization in at least a first magnetic state with a magnetic flux in a first direction and a second magnetic state with a magnetic flux in a second direction. The transformer cores retain the first magnetic state and the second magnetic state without current flow through said plurality of transformers. Circuitry is utilized for switching a selected transformer core between the first and second magnetic states to sense voltage and/or balance particular cells or particular banks of cells.

  9. Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans.

    Science.gov (United States)

    Castellino, Stephen; Moss, Lee; Wagner, David; Borland, Julie; Song, Ivy; Chen, Shuguang; Lou, Yu; Min, Sherene S; Goljer, Igor; Culp, Amanda; Piscitelli, Stephen C; Savina, Paul M

    2013-08-01

    The pharmacokinetics, metabolism, and excretion of dolutegravir, an unboosted, once-daily human immunodeficiency virus type 1 integrase inhibitor, were studied in healthy male subjects following single oral administration of [(14)C]dolutegravir at a dose of 20 mg (80 μCi). Dolutegravir was well tolerated, and absorption of dolutegravir from the suspension formulation was rapid (median time to peak concentration, 0.5 h), declining in a biphasic fashion. Dolutegravir and the radioactivity had similar terminal plasma half-lives (t1/2) (15.6 versus 15.7 h), indicating metabolism was formation rate limited with no long-lived metabolites. Only minimal association with blood cellular components was noted with systemic radioactivity. Recovery was essentially complete (mean, 95.6%), with 64.0% and 31.6% of the dose recovered in feces and urine, respectively. Unchanged dolutegravir was the predominant circulating radioactive component in plasma and was consistent with minimal presystemic clearance. Dolutegravir was extensively metabolized. An inactive ether glucuronide, formed primarily via UGT1A1, was the principal biotransformation product at 18.9% of the dose excreted in urine and the principal metabolite in plasma. Two minor biotransformation pathways were oxidation by CYP3A4 (7.9% of the dose) and an oxidative defluorination and glutathione substitution (1.8% of the dose). No disproportionate human metabolites were observed.

  10. The Balanced Scorecard: A Systemic Model for Evaluation and Assessment of Learning Outcomes?

    Directory of Open Access Journals (Sweden)

    Tom Bielavitz

    2010-06-01

    Full Text Available Objective – The goal of this paper is to explore using Kaplan and Norton’s balanced scorecard methodology as a systemic model for outcomes assessment. The expectations of academic accrediting agencies have shifted from measurement of inputs and outputs to that of the library’s impact on learning and demonstrating accountability. Recent literature has presented methods for performing specific aspects of outcomes assessment. However, the scorecard methodology may provide a systemic advantage beneficial to library administrators and managers.Methods – This paper provides a selective review of outcomes assessment in academic libraries and a description of the balanced scorecard methodology, focusing on its relevance to assessment and demonstration of accountability.Results – A theoretical scenario is outlined, including examples of a scorecard used for outcomes assessment. For each example, the benefits of using a systemic approach are examined.Conclusions – Using a systems‐thinking approach to outcomes assessment may provide significant advantages to library administrators and managers. As the model includes traditional methods of outcomes assessment, the scorecard approach adds elements of process improvement, identification of the inputs and outputs that create outcomes, and a tool for communicating accountability for resources.

  11. “Feed Assist”- An Expert System on Balanced Feeding for Dairy Animals

    Directory of Open Access Journals (Sweden)

    U.B Angadi

    2016-09-01

    Full Text Available Inadequate feeding is the major factor for low livestock productivity in India. In dairying, feed cost is a major input and feeding practices has to be improved to ensure profits. Still the small scale farmers are following traditional feeding practices and fail to address the complexities involved in ration formulation. To address the complexities in ration balancing based on the nutrient requirements for different categories of livestock, nutrient composition of wide range of feed resources and the cost - a number of expert systems have been developed. However existing expert systems have not been widely used by majority of small farmers due to lack of awareness, access and basic skills required to operate. To address these limitations, “Feed Assist” a farmer friendly expert system for balanced feeding of dairy animals at least cost has been developed using linear programming. “Feed Assist” does not require much expertise to operate and enables the farmers to formulate least cost rations for different categories of livestock using locally available feed resources.

  12. The quantum human central neural system.

    Science.gov (United States)

    Alexiou, Athanasios; Rekkas, John

    2015-01-01

    In this chapter we present Excess Entropy Production for human aging system as the sum of their respective subsystems and electrophysiological status. Additionally, we support the hypothesis of human brain and central neural system quantumness and we strongly suggest the theoretical and philosophical status of human brain as one of the unknown natural Dirac magnetic monopoles placed in the center of a Riemann sphere.

  13. Balancing Human and Inter-Agent Influences for Shared Control of Bio-Inspired Collectives

    Science.gov (United States)

    2014-10-01

    multiple uavs ,” IEEE Robotics and Automation Magazine, 2009. [4] Z. Kira and M. A. Potter, “Exerting human control over decentral- ized robot swarms ,” in...how influence is shared between the human and the swarm and (2) the resulting success of the human- swarm interaction. Note that related literature...control is shared: persistence and span. We define per- sistence as how long the human signals the swarm and span as how many agents the human

  14. Conjoint Analysis of the Surface and Atmospheric Water Balances of the Andes-Amazon System

    Science.gov (United States)

    Builes-Jaramillo, Alejandro; Poveda, Germán

    2017-04-01

    Acknowledging the interrelation between the two branches of the hydrological cycle, we perform a comprehensive analysis of the long-term mean surface and atmospheric water balances in the Amazon-Andes River basins system. We estimate the closure of the water budgets based on the long-term approximation of the water balance equations, and estimate the imbalance between both atmospheric and surface budgets. The analysis was performed with observational and reanalysis datasets for the entire basin, for several sub-catchments inside the entire Amazon River basin and for two physical and geographical distinctive subsystems of the basin, namely upper Andean the low-lying Amazon River basin. Our results evidence that for the entire Amazon River basin the surface water balance can be considered to be in balance (P = 2225 mm.yr-1, ET= 1062 mm.yr-1, R= 965 mm.yr-1), whereas for the separated subsystems it not so clear, showing high discrepancies between observations and reanalysis datasets. In turn, the atmospheric budget does not close regardless of datasets or geographical disaggregation. Our results indicate that the amount of imbalance of the atmospheric branch of the water balance depends on the evaporation data source used. The imbalance calculated as I=(C/R)-1, where C is net moisture convergence (C= -∇Q where ∇Q is the net vertically integrated moisture divergence) and R the runoff,represents the difference between the two branches of the hydrological cycle. For the entire Amazon River basin we found a consistent negative imbalance driven by higher values of runoff, and when calculated for monthly time scales the imbalance is characterized by a high dependence on the Amazon dry season. The separated analysis performed to the Andes and Low-lying Amazonia subsystems unveils two shortcomings of the available data, namely a poor quality of the representation of surface processes in the reanalysis models (including precipitation and evapotranspiration), and the

  15. Reduced storage and balancing needs in a fully renewable European power system with excess wind and solar power generation

    DEFF Research Database (Denmark)

    Heide, Dominik; Greiner, Martin; von Bremen, Lüder

    2011-01-01

    The storage and balancing needs of a simplified European power system, which is based on wind and solar power generation only, are derived from an extensive weather-driven modeling of hourly power mismatches between generation and load. The storage energy capacity, the annual balancing energy...... and the balancing power are found to depend significantly on the mixing ratio between wind and solar power generation. They decrease strongly with the overall excess generation. At 50% excess generation the required long-term storage energy capacity and annual balancing energy amount to 1% of the annual consumption....... The required balancing power turns out to be 25% of the average hourly load. These numbers are in agreement with current hydro storage lakes in Scandinavia and the Alps, as well as with potential hydrogen storage in mostly North-German salt caverns....

  16. Reduced storage and balancing needs in a fully renewable European power system with excess wind and solar power generation

    DEFF Research Database (Denmark)

    Heide, Dominik; Greiner, Martin; von Bremen, Lüder

    The storage and balancing needs of a simplified European power system, which is based on wind and solar power generation only, are derived from an extensive weather-driven modeling of hourly power mismatches between generation and load. The storage energy capacity, the annual balancing energy...... and the balancing power are found to depend significantly on the mixing ratio between wind and solar power generation. They decrease strongly with the overall excess generation. At 50% excess generation the required long-term storage energy capacity and annual balancing energy amount to 1% of the annual consumption....... The required balancing power turns out to be 25% of the average hourly load. These numbers are in agreement with current hydro storage lakes in Scandinavia and the Alps, as well as with potential hydrogen storage in mostly North-German salt caverns....

  17. A Plantar-pressure Based Tongue-placed Tactile Biofeedback System for Balance Improvement

    CERN Document Server

    Vuillerme, Nicolas; Pinsault, Nicolas; Fleury, Anthony; Demongeot, Jacques; Payan, Yohan

    2007-01-01

    Maintaining an upright stance represents a complex task, which is achieved by integrating sensory information from the visual, vestibular and somatosensory systems. When one of these sensory inputs becomes unavailable and/or inaccurate and/or unreliable, postural control generally is degraded. One way to solve this problem is to supplement and/or substitute limited/altered/missing sensory information by providing additional sensory information to the central nervous system via an alternative sensory modality. Along these lines, we developed an original biofeedback system [1] whose underlying principle consists in supplying the user with supplementary sensory information related to foot sole pressure distribution through a tongue-placed output device (Tongue Display Unit, "TDU" [2]). The purpose of the present experiment was to assess its effectiveness in improving balance in young healthy adults.

  18. Role of the endocannabinoid system in energy balance regulation and obesity.

    Science.gov (United States)

    Cota, Daniela

    2008-01-01

    The endogenous cannabinoid system (ECS) is a neuromodulatory system recently recognized to have a role in the regulation of various aspects of eating behavior and energy balance through central and peripheral mechanisms. In the central nervous system, cannabinoid type 1 receptors and their endogenous ligands, the endocannabinoids, are involved in modulating food intake and motivation to consume palatable food. Moreover, the ECS is present in peripheral organs, such as liver, white adipose tissue, muscle, and pancreas, where it seems to be involved in the regulation of lipid and glucose homeostasis. Dysregulation of the ECS has been associated with the development of obesity and its sequelae, such as dyslipidemia and diabetes. Conversely, recent clinical trials have shown that cannabinoid type 1 receptor blockade may ameliorate these metabolic abnormalities. Although further investigation is needed to better define the actual mechanisms of action, pharmacologic approaches targeting the ECS may provide a novel, effective option for the management of obesity, type 2 diabetes and cardiovascular disease.

  19. Balance in Assessment

    Science.gov (United States)

    White, Richard

    2007-01-01

    The review by Black and Wiliam of national systems makes clear the complexity of assessment, and identifies important issues. One of these is "balance": balance between local and central responsibilities, balance between the weights given to various purposes of schooling, balance between weights for various functions of assessment, and balance…

  20. Balance Improvement Effects of Biofeedback Systems with State-of-the-Art Wearable Sensors: A Systematic Review.

    Science.gov (United States)

    Ma, Christina Zong-Hao; Wong, Duo Wai-Chi; Lam, Wing Kai; Wan, Anson Hong-Ping; Lee, Winson Chiu-Chun

    2016-03-25

    Falls and fall-induced injuries are major global public health problems. Balance and gait disorders have been the second leading cause of falls. Inertial motion sensors and force sensors have been widely used to monitor both static and dynamic balance performance. Based on the detected performance, instant visual, auditory, electrotactile and vibrotactile biofeedback could be provided to augment the somatosensory input and enhance balance control. This review aims to synthesize the research examining the effect of biofeedback systems, with wearable inertial motion sensors and force sensors, on balance performance. Randomized and non-randomized clinical trials were included in this review. All studies were evaluated based on the methodological quality. Sample characteristics, device design and study characteristics were summarized. Most previous studies suggested that biofeedback devices were effective in enhancing static and dynamic balance in healthy young and older adults, and patients with balance and gait disorders. Attention should be paid to the choice of appropriate types of sensors and biofeedback for different intended purposes. Maximizing the computing capacity of the micro-processer, while minimizing the size of the electronic components, appears to be the future direction of optimizing the devices. Wearable balance-improving devices have their potential of serving as balance aids in daily life, which can be used indoors and outdoors.

  1. Balance Improvement Effects of Biofeedback Systems with State-of-the-Art Wearable Sensors: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Christina Zong-Hao Ma

    2016-03-01

    Full Text Available Falls and fall-induced injuries are major global public health problems. Balance and gait disorders have been the second leading cause of falls. Inertial motion sensors and force sensors have been widely used to monitor both static and dynamic balance performance. Based on the detected performance, instant visual, auditory, electrotactile and vibrotactile biofeedback could be provided to augment the somatosensory input and enhance balance control. This review aims to synthesize the research examining the effect of biofeedback systems, with wearable inertial motion sensors and force sensors, on balance performance. Randomized and non-randomized clinical trials were included in this review. All studies were evaluated based on the methodological quality. Sample characteristics, device design and study characteristics were summarized. Most previous studies suggested that biofeedback devices were effective in enhancing static and dynamic balance in healthy young and older adults, and patients with balance and gait disorders. Attention should be paid to the choice of appropriate types of sensors and biofeedback for different intended purposes. Maximizing the computing capacity of the micro-processer, while minimizing the size of the electronic components, appears to be the future direction of optimizing the devices. Wearable balance-improving devices have their potential of serving as balance aids in daily life, which can be used indoors and outdoors.

  2. Mineral balance, experiment M071. [space flight effects on human mineral metabolism

    Science.gov (United States)

    Whedon, G. D.; Rambaut, P. C.; Smith, M. C., Jr.

    1973-01-01

    Concern for the long term metabolic consequences of weightless flight was the basis for the conception of the Skylab medical experiment to measure mineral balance. Proper interpretation of obtained data that diminished atmospheric pressure has no appreciable effect, or at least no protective effect, on calcium metabolism. The absence of changes in calcium metabolism indicates that a stable baseline observation has been made for Skylab as far as the effects of atmosphere or calcium metabolism are concerned.

  3. Using the balanced scorecard to mobilize human resources in organizational transformation.

    Science.gov (United States)

    Tsasis, Peter; Harber, Bruce

    2008-05-01

    Traditionally, the balanced scorecard (BSC) has been an effective tool in linking measurement to strategy. However, what is least understood is how the BSC can be used to redefine organizational relationships, re-engineer fundamental processes and transform organizational culture, for superior performance in an organization with the same people, services and technology that previously delivered dismal performance. This paper highlights the process and uses York Central Hospital in Toronto, Ontario, Canada as an illustrative example.

  4. Fundamentals of systems ergonomics/human factors.

    Science.gov (United States)

    Wilson, John R

    2014-01-01

    Ergonomics/human factors is, above anything else, a systems discipline and profession, applying a systems philosophy and systems approaches. Many things are labelled as system in today's world, and this paper specifies just what attributes and notions define ergonomics/human factors in systems terms. These are obviously a systems focus, but also concern for context, acknowledgement of interactions and complexity, a holistic approach, recognition of emergence and embedding of the professional effort involved within organization system. These six notions are illustrated with examples from a large body of work on rail human factors.

  5. Human Factors Interface with Systems Engineering for NASA Human Spaceflights

    Science.gov (United States)

    Wong, Douglas T.

    2009-01-01

    This paper summarizes the past and present successes of the Habitability and Human Factors Branch (HHFB) at NASA Johnson Space Center s Space Life Sciences Directorate (SLSD) in including the Human-As-A-System (HAAS) model in many NASA programs and what steps to be taken to integrate the Human-Centered Design Philosophy (HCDP) into NASA s Systems Engineering (SE) process. The HAAS model stresses systems are ultimately designed for the humans; the humans should therefore be considered as a system within the systems. Therefore, the model places strong emphasis on human factors engineering. Since 1987, the HHFB has been engaging with many major NASA programs with much success. The HHFB helped create the NASA Standard 3000 (a human factors engineering practice guide) and the Human Systems Integration Requirements document. These efforts resulted in the HAAS model being included in many NASA programs. As an example, the HAAS model has been successfully introduced into the programmatic and systems engineering structures of the International Space Station Program (ISSP). Success in the ISSP caused other NASA programs to recognize the importance of the HAAS concept. Also due to this success, the HHFB helped update NASA s Systems Engineering Handbook in December 2007 to include HAAS as a recommended practice. Nonetheless, the HAAS model has yet to become an integral part of the NASA SE process. Besides continuing in integrating HAAS into current and future NASA programs, the HHFB will investigate incorporating the Human-Centered Design Philosophy (HCDP) into the NASA SE Handbook. The HCDP goes further than the HAAS model by emphasizing a holistic and iterative human-centered systems design concept.

  6. Development of a PEMFC Power System with Integrated Balance of Plant

    Science.gov (United States)

    Wynne, B.; Diffenderfer, C.; Ferguson, S.; Keyser, J.; Miller, M.; Sievers, B.; Ryan, A.; Vasquez, A.

    2012-01-01

    Autonomous Underwater Vehicles (AUV s) have received increasing attention in recent years as military and commercial users look for means to maintain a mobile and persistent presence in the undersea world. Compact, neutrally buoyant power systems are needed for both small and large vehicles. Batteries are usually employed in these applications, but the energy density and therefore the mission duration are limited with current battery technology. At a certain energy or mission duration requirement, other means to get long duration power become feasible. For example, above 10 kW-hrs liquid oxygen and hydrogen have better specific energy than batteries and are preferable for energy storage as long as a compact system of about 100 W/liter is achievable to convert the chemical energy in these reactants into power. Other reactant forms are possible, such as high pressure gas, chemical hydrides or oxygen carriers, but it is essential that the power system be small and light weight. Recent fuel cell work, primarily focused on NASA applications, has developed power systems that can meet this target power density. Passive flow-through systems, using ejector driven reactant (EDR) flow, integrated into a compact balance of plant have been developed. These systems are thermally and functionally integrated in much the same way as are automotive, air breathing fuel cell systems. These systems fit into the small volumes required for AUV and future NASA applications. Designs have been developed for both a 21" diameter and a larger diameter (LD) AUV. These fuel cell systems occupy a very small portion of the overall energy system, allowing most of the system volume to be used for the reactants. The fuel cell systems have been optimized to use reactants efficiently with high stack efficiency and low parasitic losses. The resulting compact, highly efficient fuel cell system provides exceptional reactant utilization and energy density. Key design variables and supporting test data are

  7. Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans?

    DEFF Research Database (Denmark)

    Sandmand, M; Bruunsgaard, H; Kemp, K

    2002-01-01

    The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression...... adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN-gamma+ and IL-4+ CD8+ T cells was still increased in the 81-year-olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8+ T cells. Furthermore...

  8. Variations of global and continental water balance components as impacted by climate forcing uncertainty and human water use

    Science.gov (United States)

    Müller Schmied, Hannes; Adam, Linda; Eisner, Stephanie; Fink, Gabriel; Flörke, Martina; Kim, Hyungjun; Oki, Taikan; Portmann, Felix Theodor; Reinecke, Robert; Riedel, Claudia; Song, Qi; Zhang, Jing; Döll, Petra

    2016-07-01

    When assessing global water resources with hydrological models, it is essential to know about methodological uncertainties. The values of simulated water balance components may vary due to different spatial and temporal aggregations, reference periods, and applied climate forcings, as well as due to the consideration of human water use, or the lack thereof. We analyzed these variations over the period 1901-2010 by forcing the global hydrological model WaterGAP 2.2 (ISIMIP2a) with five state-of-the-art climate data sets, including a homogenized version of the concatenated WFD/WFDEI data set. Absolute values and temporal variations of global water balance components are strongly affected by the uncertainty in the climate forcing, and no temporal trends of the global water balance components are detected for the four homogeneous climate forcings considered (except for human water abstractions). The calibration of WaterGAP against observed long-term average river discharge Q significantly reduces the impact of climate forcing uncertainty on estimated Q and renewable water resources. For the homogeneous forcings, Q of the calibrated and non-calibrated regions of the globe varies by 1.6 and 18.5 %, respectively, for 1971-2000. On the continental scale, most differences for long-term average precipitation P and Q estimates occur in Africa and, due to snow undercatch of rain gauges, also in the data-rich continents Europe and North America. Variations of Q at the grid-cell scale are large, except in a few grid cells upstream and downstream of calibration stations, with an average variation of 37 and 74 % among the four homogeneous forcings in calibrated and non-calibrated regions, respectively. Considering only the forcings GSWP3 and WFDEI_hom, i.e., excluding the forcing without undercatch correction (PGFv2.1) and the one with a much lower shortwave downward radiation SWD than the others (WFD), Q variations are reduced to 16 and 31 % in calibrated and non

  9. Psychometric properties of Brief-Balance Evaluation Systems Test (Brief-BESTest) in evaluating balance performance in individuals with chronic stroke.

    Science.gov (United States)

    Huang, Meizhen; Pang, Marco Y C

    2017-03-01

    To examine the psychometric properties of the Brief-Balance Evaluation Systems Test (Brief-BESTest) in individuals with chronic stroke. This was an observational study with repeated measurements involving 50 participants with chronic stroke [mean (SD) age: 59.2 (7.3) years]. Each participant with stroke was evaluated with the Brief-BESTest, Berg balance scale (BBS), Postural Assessment Scale for Stroke Patients (PASS), Fugl-Meyer Motor Assessment (FMA), Chedoke-McMaster Stroke Assessment (CMSA), Montreal Cognitive Assessment (MoCA), and Geriatric Depression Scale (GDS). Two raters (rater 1 and 2) provided the Brief-BESTest scores of the first 27 participants independently to establish inter-rater reliability. After 15 min of rest, the same 27 participants were evaluated with the Brief-BESTest again by rater 1 to establish intra-rater reliability. The Brief-BESTest scores of the stroke group were also compared with those of the control group [n = 27, mean (SD) age: 56.7 (7.7) years]. The Brief-BESTest had no substantial floor and ceiling effects, good intra-rater (ICC 2,1 = 0.974) and inter-rater (ICC 2,1 = 0.980) reliability and internal consistency (Cronbach's alpha = 0.818). The minimal detectable change at 95% confidence level was 2 points. The Brief-BESTest showed moderate to very strong correlations with other balance (BBS and PASS) and motor impairment (FMA, CMSA) measures (rs = .547-.911, p Brief-BESTest was effective in distinguishing participants with stroke from controls (cutoff score: Brief-BESTest has good reliability and validity in assessing balance function in individuals with chronic stroke.

  10. The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation.

    Science.gov (United States)

    Di Marzo, V; Ligresti, A; Cristino, L

    2009-06-01

    The endocannabinoid system (ECS) and, in particular, cannabinoid CB(1) receptors, their endogenous agonists (the endocannabinoids anandamide and 2-arachidonoylglycerol) and enzymes for the biosynthesis and degradation of the latter mediators are emerging as key players in the control of all aspects of food intake and energy balance. The ECS is involved in stimulating both the homoeostatic (that is, the sensing of deficient energy balance and gastrointestinal load) and the hedonic (that is, the sensing of the salience and the incentive/motivational value of nutrients) aspects of food intake. The orexigenic effects of endocannabinoids are exerted in the brain by CB(1)-mediated stimulatory and inhibitory effects on hypothalamic orexigenic and anorectic neuropeptides, respectively; by facilitatory actions on dopamine release in the nucleus accumbens shell; and by regulating the activity of sensory and vagal fibres in brainstem-duodenum neural connections. In turn, the levels of anandamide and 2-arachidonoylglycerol and/or CB(1) receptors in the brain are under the control of leptin, ghrelin and glucocorticoids in the hypothalamus, under that of dopamine in the limbic forebrain and under that of cholecystokinin and ghrelin in the brainstem. These bi-directional communications between the ECS and other key players in energy balance ensure local mediators such as the endocannabinoids to act in a way coordinated in both 'space' and 'time' to enhance food intake, particularly after a few hours of food deprivation. Alterations of such communications are, however, also among the underlying causes of overactivity of the ECS in hyperphagia and obesity, a phenomenon that provided the rationale for the development of anti-obesity drugs from CB(1) receptor antagonists.

  11. Characteristics of nitrogen balance in open-air and greenhouse vegetable cropping systems of China.

    Science.gov (United States)

    Ti, Chaopu; Luo, Yongxia; Yan, Xiaoyuan

    2015-12-01

    Nitrogen (N) loss from vegetable cropping systems has become a significant environmental issue in China. In this study, estimation of N balances in both open-air and greenhouse vegetable cropping systems in China was established. Results showed that the total N input in open-air and greenhouse vegetable cropping systems in 2010 was 5.44 and 2.60 Tg, respectively. Chemical fertilizer N input in the two cropping systems was 201 kg N ha(-1) per season (open-air) and 478 kg N ha(-1) per season (greenhouse). The N use efficiency (NUE) was 25.9 ± 13.3 and 19.7 ± 9.4% for open-air and greenhouse vegetable cropping systems, respectively, significantly lower than that of maize, wheat, and rice. Approximately 30.6% of total N input was accumulated in soils and 0.8% was lost by ammonia volatilization in greenhouse vegetable system, while N accumulation and ammonia volatilization accounted for 19.1 and 11.1%, respectively, of total N input in open-air vegetable systems.

  12. Design and development of major balance of plant components in solid oxide fuel cell system

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Wen-Tang; Huang, Cheng-Nan; Tan, Hsueh-I; Chao, Yu [Institute of Nuclear Energy Research Atomic Energy Council, Taoyuan County 32546 (Taiwan, Province of China); Yen, Tzu-Hsiang [Green Technology Research Institute, CPC Corporation, Chia-Yi City 60036 (Taiwan, Province of China)

    2013-07-01

    The balance of plant (BOP) of a Solid Oxide Fuel Cell (SOFC) system with a 2 kW stack and an electric efficiency of 40% is optimized using commercial GCTool software. The simulation results provide a detailed understanding of the optimal operating temperature, pressure and mass flow rate in all of the major BOP components, i.e., the gas distributor, the afterburner, the reformer and the heat exchanger. A series of experimental trials are performed to validate the simulation results. Overall, the results presented in this study not only indicate an appropriate set of operating conditions for the SOFC power system, but also suggest potential design improvements for several of the BOP components.

  13. Cross-correlation of output fluctuation and system-balancing cost in photovoltaic integration

    Directory of Open Access Journals (Sweden)

    Yuichi Ikeda

    2014-10-01

    Full Text Available The authors analysed the cross-correlation of photovoltaic (PV output fluctuation for the actual PV output time series data in both the Tokyo area and the whole of Japan using the principal component analysis with the random matrix theory. Based on the obtained cross-correlation coefficients, the forecast error for PV output was estimated with/without considering the cross-correlations. Then the operation schedule of thermal plants is calculated to integrate PV output using the proposed unit commitment model with the estimated forecast error. The system-balancing cost of PV system was also estimated with or without demand response. Finally, validity of the concept of ‘local production for local consumption of renewable energy’ and alternative policy implications were discussed.

  14. Nonequilibrium steady state in open quantum systems: Influence action, stochastic equation and power balance

    Energy Technology Data Exchange (ETDEWEB)

    Hsiang, J.-T., E-mail: cosmology@gmail.com [Center for Field Theory and Particle Physics, Fudan University, Shanghai 200433 (China); Department of Physics, National Dong Hwa University, Hualien 97401, Taiwan (China); Hu, B.L. [Center for Field Theory and Particle Physics, Fudan University, Shanghai 200433 (China); Joint Quantum Institute and Maryland Center for Fundamental Physics, University of Maryland, College Park, MD 20742 (United States)

    2015-11-15

    The existence and uniqueness of a steady state for nonequilibrium systems (NESS) is a fundamental subject and a main theme of research in statistical mechanics for decades. For Gaussian systems, such as a chain of classical harmonic oscillators connected at each end to a heat bath, and for classical anharmonic oscillators under specified conditions, definitive answers exist in the form of proven theorems. Answering this question for quantum many-body systems poses a challenge for the present. In this work we address this issue by deriving the stochastic equations for the reduced system with self-consistent backaction from the two baths, calculating the energy flow from one bath to the chain to the other bath, and exhibiting a power balance relation in the total (chain + baths) system which testifies to the existence of a NESS in this system at late times. Its insensitivity to the initial conditions of the chain corroborates to its uniqueness. The functional method we adopt here entails the use of the influence functional, the coarse-grained and stochastic effective actions, from which one can derive the stochastic equations and calculate the average values of physical variables in open quantum systems. This involves both taking the expectation values of quantum operators of the system and the distributional averages of stochastic variables stemming from the coarse-grained environment. This method though formal in appearance is compact and complete. It can also easily accommodate perturbative techniques and diagrammatic methods from field theory. Taken all together it provides a solid platform for carrying out systematic investigations into the nonequilibrium dynamics of open quantum systems and quantum thermodynamics. -- Highlights: •Nonequilibrium steady state (NESS) for interacting quantum many-body systems. •Derivation of stochastic equations for quantum oscillator chain with two heat baths. •Explicit calculation of the energy flow from one bath to the

  15. Coupled Human-Atmosphere-System Thinking

    Science.gov (United States)

    Schmale, Julia; Chabay, Ilan

    2014-05-01

    With the discovery of fire, humankind started changing the composition of the atmosphere. Beginning with the industrial revolution, this has led to significant environmental problems, mainly air pollution and climate change. While climate change has been recognized as one key challenge of the Anthropocene, air pollution contributes to the top causes of global premature mortality. Air pollution also plays a key role in contamination of ecosystems and bio-magnification of toxins along food chains. Even though emissions leading to air pollution and climate change often originate from the same sources, they are generally perceived and regulated separately. Climate change impacts are global and hence are tackled at an international level. Conversely, air pollution has local to regional impacts and is thus a matter of national or regional legislation. This legislative and policy divide is generally useful, since full integration could lead, for example, to detrimental delays in action against air pollution through protracted international climate negotiations. However, the separation obscures the fact that almost any kind of human activity leads to the simultaneous emission of air pollutants, toxins and long-lived greenhouse gases. The atmosphere functions as a "dump" for human generated gaseous waste, which is then dispersed and transformed, partly chemically and partly micro-physically, perturbing natural processes in the atmosphere and leading to manifold impacts. In addition, air pollutants affect the Earth's radiative balance directly and indirectly, hence affecting climate change, while a changing climate in turn affects air pollution. Current policies often neglect these linkages and favor mitigation in one arena, which sometimes has detrimental effects on the other. One example is domestic wood burning, which though nearly carbon neutral, deteriorates air quality. Moreover, the design of appliances, machinery, or infrastructure generally does not attempt to

  16. Balanced Scorecard--A Strategic Management System of the Higher Education Institution

    Science.gov (United States)

    Hladchenko, Myroslava

    2015-01-01

    Purpose: The purpose of this paper is to focus on the comparative analysis of the Balanced Scorecards of four higher education institutions and aims to define the general framework of the Balanced Scorecard for the higher education institution which concerns: the structure and elements of the Balanced Scorecard; development of the Balanced…

  17. Balanced Scorecard--A Strategic Management System of the Higher Education Institution

    Science.gov (United States)

    Hladchenko, Myroslava

    2015-01-01

    Purpose: The purpose of this paper is to focus on the comparative analysis of the Balanced Scorecards of four higher education institutions and aims to define the general framework of the Balanced Scorecard for the higher education institution which concerns: the structure and elements of the Balanced Scorecard; development of the Balanced…

  18. A Virtual Reality-Cycling Training System for Lower Limb Balance Improvement

    Directory of Open Access Journals (Sweden)

    Chieh Yin

    2016-01-01

    Full Text Available Stroke survivors might lose their walking and balancing abilities, but many studies pointed out that cycling is an effective means for lower limb rehabilitation. However, during cycle training, the unaffected limb tends to compensate for the affected one, which resulted in suboptimal rehabilitation. To address this issue, we present a Virtual Reality-Cycling Training System (VRCTS, which senses the cycling force and speed in real-time, analyzes the acquired data to produce feedback to patients with a controllable VR car in a VR rehabilitation program, and thus specifically trains the affected side. The aim of the study was to verify the functionality of the VRCTS and to verify the results from the ten stroke patients participants and to compare the result of Asymmetry Ratio Index (ARI between the experimental group and the control group, after their training, by using the bilateral pedal force and force plate to determine any training effect. The results showed that after the VRCTS training in bilateral pedal force it had improved by 0.22 (p=0.046 and in force plate the stand balance has also improved by 0.29 (p=0.031; thus both methods show the significant difference.

  19. Assessment of green roof systems in terms of water and energy balance

    Directory of Open Access Journals (Sweden)

    Mert Ekşi

    2016-01-01

    Full Text Available Green roofs concept term is used for extensive green roofs which are planted with herbaceous plants that can be adapted into changeable environmental conditions on a shallow substrate layer, require minimal maintenance, installed for their benefits to building and urban scale. Main objective of this study is to determine the characteristics of a green roof such as thermal insulation, water holding capacity, runoff characteristics, plant growth and its interaction with environmental factors in Istanbul climate conditions by performing comparative measurements. In this study, a research site (IU Green Roof Research Station was founded to assess water and energy balance of green roofs. Thus, a typical green roof was evaluated in terms of water and energy balance and its interaction with the building and city was determined. energy efficiency of green roof system was 77% higher than reference roof. Temperature fluctuations on green roof section of the roof were 79% lower. In addition, green roof retained 12,8% - 100% of precipitation and delayed runoff up to 23 hours depending on water content of substrate.

  20. A Virtual Reality-Cycling Training System for Lower Limb Balance Improvement.

    Science.gov (United States)

    Yin, Chieh; Hsueh, Ya-Hsin; Yeh, Chun-Yu; Lo, Hsin-Chang; Lan, Yi-Ting

    2016-01-01

    Stroke survivors might lose their walking and balancing abilities, but many studies pointed out that cycling is an effective means for lower limb rehabilitation. However, during cycle training, the unaffected limb tends to compensate for the affected one, which resulted in suboptimal rehabilitation. To address this issue, we present a Virtual Reality-Cycling Training System (VRCTS), which senses the cycling force and speed in real-time, analyzes the acquired data to produce feedback to patients with a controllable VR car in a VR rehabilitation program, and thus specifically trains the affected side. The aim of the study was to verify the functionality of the VRCTS and to verify the results from the ten stroke patients participants and to compare the result of Asymmetry Ratio Index (ARI) between the experimental group and the control group, after their training, by using the bilateral pedal force and force plate to determine any training effect. The results showed that after the VRCTS training in bilateral pedal force it had improved by 0.22 (p = 0.046) and in force plate the stand balance has also improved by 0.29 (p = 0.031); thus both methods show the significant difference.

  1. Evaluation of postural balance in mild cognitive impairment through a three-dimensional electromagnetic system.

    Science.gov (United States)

    Borges, Ana Paula Oliveira; Carneiro, José Ailton Oliveira; Zaia, José Eduardo; Carneiro, Antonio Adilton Oliveira; Takayanagui, Osvaldo Massaiti

    2016-01-01

    Elderly people with cognitive impairment are at greater risk for falls; thus, an understanding of the earliest stages of cognitive decline is necessary. To compare postural balance between elderly people with and without mild cognitive impairment using a three-dimensional system. Thirty elderly people with mild cognitive impairment and thirty healthy elderly subjects were selected. Static posturography was performed using three-dimensional electromagnetic equipment and the following parameters were evaluated: maximum displacement, mean speed and total trajectory. Open- and closed-eye stabilometric variable comparisons between groups and within each group were carried out, and a relationship between the Mini Mental State Examination and the total trajectory of all elderly subjects was determined. The analysis among open- and closed-eye conditions showed a significant difference in maximum anteroposterior displacement in the control group and a significant difference in all stabilometric variables in the mild cognitive impairment group. A significant difference between the groups in all variables in the closed-eye condition was observed. There was a strong correlation between cognitive performance and total trajectory. Evaluations showed decrease in balance in elderly people with mild cognitive impairment. Presence of anteroposterior displacement can be an early sign of postural control impairment, and the evaluation with visual restriction can be useful in detecting small postural instabilities. Copyright © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

  2. Fresh water balance of the Gulf Stream system in a regional model study

    Energy Technology Data Exchange (ETDEWEB)

    Gerdes, R. [Alfred-Wegener-Institut fuer Polar- und Meeresforschung, Bremerhaven (Germany); Biastoch, A. [California Univ., San Diego, La Jolla, CA (United States). Scripps Inst. of Oceanography; Redler, R. [SCAI Inst. for Algorithms and Scientific Computing, German National Research Center for Information Technology, Sankt Augustin (Germany)

    2001-11-01

    We investigate the dependence of surface fresh water fluxes in the Gulf Stream and North Atlantic Current (NAC) area on the position of the stream axis which is not well represented in most ocean models. To correct this shortcoming, strong unrealistic surface fresh water fluxes have to be applied that lead to an incorrect salt balance of the current system. The unrealistic surface fluxes required by the oceanic component may force flux adjustments and may cause fictitious long-term variability in coupled climate models. To identify the important points in the correct representation of the salt balance of the Gulf Stream a regional model of the northwestern part of the subtropical gyre has been set up. Sensitivity studies are made where the westward flow north of the Gulf Stream and its properties are varied. Increasing westward volume transport leads to a southward migration of the Gulf Stream separation point along the American coast. The salinity of the inflow is essential for realistic surface fresh water fluxes and the water mass distribution. The subpolar-subtropical connection is important in two ways: The deep dense flow from the deep water mass formation areas sets up the cyclonic circulation cell north of the Gulf Stream. The surface and mid depth flow of fresh water collected at high northern latitudes is mixed into the Gulf Stream and compensates for the net evaporation at the surface. (orig.)

  3. Bringing human resources to the table: utilization of an HR balanced scorecard at Mayo Clinic.

    Science.gov (United States)

    Fottler, Myron D; Erickson, Eric; Rivers, Patrick A

    2006-01-01

    Rather than viewing HR as a critical driver of organizational strategy and outcomes, most health care organizations see HR as a drain on the organization's bottom line. Only by aligning HR with the organizational strategy will HR leaders truly get a seat at the leadership table. HR professionals can overcome impediments and gain a seat at the table by learning the language of business and the ways in which organizational leaders use data to drive their decisions. This article shows how Mayo Clinic uses the popular Balanced Scorecard approach to align its measures of HR performance to the organization's strategic plan.

  4. ANALYSIS OF THE HARMONIC LOSSES WITH ARTIFICIAL NEURAL NETWORKS IN UNBALANCED SYSTEM LOSSES USING BALANCED ELECTRIC POWER SYSTEM DATA

    Directory of Open Access Journals (Sweden)

    Aslan İNAN

    2005-01-01

    Full Text Available The losses in the power systems should be low as possible as. Saving energy instead of loses (kWh in power utilities can supply much more energy to the consumers. The lower losses the more energy is saved and thus the power system becomes more economical. In recent years, the increasing number of applications and power ratings of the devices which have nonlinear voltage-current characteristics cause voltage waveform distortion and additional losses. While evaluating losses considering harmonics will provide more contribution to obtain more accurate results. In this study, Artificial Neural Networks (ANN method has been presented to predict the harmonic losses in unbalanced power systems by using the data from balanced power system with nonlinear loads.

  5. Distributed Human Resource Redistribution System Based on Agent and Ontology

    Institute of Scientific and Technical Information of China (English)

    Li Xiangquan; Wang Ningsheng; Long Wen

    2006-01-01

    A computer system for human resource (HR) redistribution system is presented to solve the balance problem of the "surplus resources" and "surplus tasks" among a group of project units. The system architecture is designed in a compositional manner using the elements of agent technology and knowledge technology. A combination of generic agent models, ontology and knowledge provides an effective approach to address the dynamic, distributed and knowledge-intensive characters of the HR management. In the system, the broker agent acting as intermediary provides matchmaking services to the domain agents, and the individual domain agents communicate directly with each other. The HR ontology provides the semantic match of the surplus task and the surplus resource. Finally, an application example is presented to illustrate the achieved solution for a concrete scenario. This novel way offers a comprehensive HR exchange solution and is suitable for both intra-organizational and inter-organizational HR management.

  6. Fertilizer {sup 15}N balance in a coffee cropping system: a case study in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Fenilli, Tatiele Anete Bergamo [Universidade Regional de Blumenau (URB), SC (Brazil). Dept. de Engenharia Florestal]. E-mail: tfenilli@furb.br; Reichardt, Klaus; Bacchi, Osny Oliveira Santos [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil). Lab. de Fisica do Solo]. E-mails: klaus@cena.usp.br; osny@cena.usp.br; Favarin, Jose Laercio [Escola Superior de Agricultura Luiz de Queiroz (ESALQ/USP), Piracicaba, SP (Brazil). Dept. de Producao Vegetal; Silva, Adriana Lucia [Centro de Tecnologia Canavieira (CTC), Piracicaba, SP (Brazil). Fazenda Santo Antonio]. E-mail: adriana.silva@ctc.com.br; Timm, Luis Carlos [Universidade Federal de Pelotas (UFPel), RS (Brazil). Dept. de Engenharia Rural]. E-mail: lcartimm@yahoo.com.br

    2008-07-15

    Knowledge about the fate of fertilizer nitrogen in agricultural systems is essential for the improvement of management practices in order to maximize nitrogen (N) recovery by the crop and reduce N losses from the system to a minimum. This study involves fertilizer management practices using the {sup 15}N isotope label applied in a single rate to determine the fertilizer-N balance in a particular soil-coffee-atmosphere system and to deepen the understanding of N plant dynamics. Five replicates consisting of plots of about 120 plants each were randomly defined within a 0.2 ha coffee plantation planted in 2001, in Piracicaba, SP, Brazil. Nine plants of each plot were separated in sub-plots for the {sup 15}N balance studies and treated with N rates of 280 and 350 kg ha-1 during 2003/2004 and 2004/ 2005, respectively, both of them as ammonium sulfate enriched to a {sup 15}N abundance of 2.072 atom %. Plant shoots were considered as separate parts: the orthotropic central branch, productive branches, leaves of productive branches, vegetative branches, leaves of vegetative branches and fruit. Litter, consisting of dead leaves accumulated below the plant canopy, was measured by the difference between leaves at harvest and at the beginning of the following flowering. Roots and soil were sampled down to a depth of 1.0 at intervals of 0.2 m. Samples from the isotopic sub-plots were used to evaluate total N and {sup 15}N, and plants outside sub-plots were used to evaluate dry matter. Volatilization losses of NH{sub 3} were estimated using special collectors. Leaching of fertilizer-N was estimated from deep drainage water fluxes and {sup 15}N concentrations of the soil solution at 1 m soil depth. At the end of the 2-year evaluation, the recovery of {sup 15}N applied as ammonium sulfate was 19.1 % in aerial plant parts, 9.4 % in the roots, 23.8 % in the litter, 26.3 % in the fruit and 12.6 % remaining in the 0-1.0 m soil profile. Annual leaching and volatilization losses were

  7. Expression of perilipins in human skeletal muscle in vitro and in vivo in relation to diet, exercise and energy balance

    DEFF Research Database (Denmark)

    Gjelstad, I M F; Haugen, F; Gulseth, H L

    2011-01-01

    , enhanced the expression of perilipin 2 and 3. Perilipin 1 mRNA correlated positively with body fat mass, whereas none of the perilipins were associated with insulin sensitivity. In conclusion, all perilipins mRNAs were expressed in human skeletal muscle. Diet as well as endurance exercise modulated......The perilipin proteins enclose intracellular lipid droplets. We describe the mRNA expression of the five perilipins in human skeletal muscle in relation to fatty acid supply, exercise and energy balance. We observed that all perilipins were expressed in skeletal muscle biopsies with the highest m......RNA levels of perilipin 2, 4 and 5. Cultured myotubes predominantly expressed perilipin 2 and 3. In vitro, incubation of myotubes with fatty acids enhanced mRNA expression of perilipin 1, 2 and 4. In vivo, low fat diet increased mRNA levels of perilipin 3 and 4. Endurance training, but not strength training...

  8. BALANCE CAPACITY WITH VARIABILITY CAUSED BY HUMAN FACTOR: AN APPLICATION IN A LINE WITH MONTE CARLO SIMULATION

    Directory of Open Access Journals (Sweden)

    Augusto Sandes Mendes

    2016-07-01

    Full Text Available The variation in processing times due to the human factor between the working stations of a production line can generate queues resulting in a higher cost to the productive process. The objective of this study was to apply Monte Carlo simulation to balance the capacity of a production line with stations suffering variability in processing time due to the human factor. Simulations of the current situation of the production line were performed by comparing it with a proposal to align capacity with the production restriction in order to reduce inventories process while maintaining full capacity of the line. To develop the study, the selection involves the case of a company’s production line in the metal industry that produces machinery and products for metalworking area. The results allowed pointing suggestions for the company to reduce in-process inventory, keeping then total capacity of the line.

  9. Micro RNAs and DNA methylation are regulatory players in human cells with altered X chromosome to autosome balance

    Science.gov (United States)

    Rajpathak, Shriram N.; Deobagkar, Deepti D.

    2017-01-01

    The gene balance hypothesis predicts that an imbalance in the dosage sensitive genes affects the cascade of gene networks that may influence the fitness of individuals. The phenotypes associated with chromosomal aneuploidies demonstrate the importance of gene dosage balance. We have employed untransformed human fibroblast cells with different number of X chromosomes to assess the expression of miRNAs and autosomal genes in addition to the DNA methylation status. High throughput NGS analysis using illumina Next seq500 has detected several autosomal as well as X linked miRNAs as differentially expressed in X monosomy and trisomy cells. Two of these miRNAs (hsa-miR-125a-5p and 335-5p) are likely to be involved in regulation of the autosomal gene expression. Additionally, our data demonstrates altered expression and DNA methylation signatures of autosomal genes in X monosomy and trisomy cells. In addition to miRNAs, expression of DNMT1 which is an important epigenetic player involved in many processes including cancer, is seen to be altered. Overall, present study provides a proof for regulatory roles of micro RNAs and DNA methylation in human X aneuploidy cells opening up possible new ways for designing therapeutic strategies. PMID:28233878

  10. Feasibility of a Low-Cost, Interactive Gaming System to Assess Balance in Older Women.

    Science.gov (United States)

    Hall, Courtney D; Clevenger, Carolyn K; Wolf, Rachel A; Lin, James S; Johnson, Theodore M; Wolf, Steven L

    2016-01-01

    The use of low-cost interactive game technology for balance rehabilitation has become more popular recently, with generally good outcomes. Very little research has been undertaken to determine whether this technology is appropriate for balance assessment. The Wii balance board has good reliability and is comparable to a research-grade force plate; however, recent studies examining the relationship between Wii Fit games and measures of balance and mobility demonstrate conflicting findings. This study found that the Wii Fit was feasible for community-dwelling older women to safely use the balance board and quickly learn the Wii Fit games. The Ski Slalom game scores were strongly correlated with several balance and mobility measures, whereas Table Tilt game scores were not. Based on these findings, the Ski Slalom game may have utility in the evaluation of balance problems in community-dwelling older adults.

  11. The Genomic Landscape of Balanced Cytogenetic Abnormalities Associated with Human Congenital Anomalies

    Science.gov (United States)

    Redin, Claire; Brand, Harrison; Collins, Ryan L.; Kammin, Tammy; Mitchell, Elyse; Hodge, Jennelle C.; Hanscom, Carrie; Pillalamarri, Vamsee; Seabra, Catarina M.; Abbott, Mary-Alice; Abdul-Rahman, Omar A.; Aberg, Erika; Adley, Rhett; Alcaraz-Estrada, Sofia L.; Alkuraya, Fowzan S.; An, Yu; Anderson, Mary-Anne; Antolik, Caroline; Anyane-Yeboa, Kwame; Atkin, Joan F.; Bartell, Tina; Bernstein, Jonathan A.; Beyer, Elizabeth; Blumenthal, Ian; Bongers, Ernie M.H.F.; Brilstra, Eva H.; Brown, Chester W.; Brüggenwirth, Hennie T.; Callewaert, Bert; Chiang, Colby; Corning, Ken; Cox, Helen; Cuppen, Edwin; Currall, Benjamin B.; Cushing, Tom; David, Dezso; Deardorff, Matthew A.; Dheedene, Annelies; D’Hooghe, Marc; de Vries, Bert B.A.; Earl, Dawn L.; Ferguson, Heather L.; Fisher, Heather; FitzPatrick, David R.; Gerrol, Pamela; Giachino, Daniela; Glessner, Joseph T.; Gliem, Troy; Grady, Margo; Graham, Brett H.; Griffis, Cristin; Gripp, Karen W.; Gropman, Andrea L.; Hanson-Kahn, Andrea; Harris, David J.; Hayden, Mark A.; Hill, Rosamund; Hochstenbach, Ron; Hoffman, Jodi D.; Hopkin, Robert J.; Hubshman, Monika W.; Innes, A. Micheil; Irons, Mira; Irving, Melita; Jacobsen, Jessie C.; Janssens, Sandra; Jewett, Tamison; Johnson, John P.; Jongmans, Marjolijn C.; Kahler, Stephen G.; Koolen, David A.; Korzelius, Jerome; Kroisel, Peter M.; Lacassie, Yves; Lawless, William; Lemyre, Emmanuelle; Leppig, Kathleen; Levin, Alex V.; Li, Haibo; Li, Hong; Liao, Eric C.; Lim, Cynthia; Lose, Edward J.; Lucente, Diane; Macera, Michael J.; Manavalan, Poornima; Mandrile, Giorgia; Marcelis, Carlo L.; Margolin, Lauren; Mason, Tamara; Masser-Frye, Diane; McClellan, Michael W.; Zepeda Mendoza, Cinthya J.; Menten, Björn; Middelkamp, Sjors; Mikami, Liya R.; Moe, Emily; Mohammed, Shehla; Mononen, Tarja; Mortenson, Megan E.; Moya, Graciela; Nieuwint, Aggie W.; Ordulu, Zehra; Parkash, Sandhya; Pauker, Susan P.; Pereira, Shahrin; Perrin, Danielle; Phelan, Katy; Piña Aguilar, Raul E.; Poddighe, Pino J.; Pregno, Giulia; Raskin, Salmo; Reis, Linda; Rhead, William; Rita, Debra; Renkens, Ivo; Roelens, Filip; Ruliera, Jayla; Rump, Patrick; Schilit, Samantha L.P.; Shaheen, Ranad; Sparkes, Rebecca; Spiegel, Erica; Stevens, Blair; Stone, Matthew R.; Tagoe, Julia; Thakuria, Joseph V.; van Bon, Bregje W.; van de Kamp, Jiddeke; van Der Burgt, Ineke; van Essen, Ton; van Ravenswaaij-Arts, Conny M.; van Roosmalen, Markus J.; Vergult, Sarah; Volker-Touw, Catharina M.L.; Warburton, Dorothy P.; Waterman, Matthew J.; Wiley, Susan; Wilson, Anna; Yerena-de Vega, Maria de la Concepcion A.; Zori, Roberto T.; Levy, Brynn; Brunner, Han G.; de Leeuw, Nicole; Kloosterman, Wigard P.; Thorland, Erik C.; Morton, Cynthia C.; Gusella, James F.; Talkowski, Michael E.

    2017-01-01

    Despite their clinical significance, characterization of balanced chromosomal abnormalities (BCAs) has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing revised 93% of karyotypes and revealed complexity that was cryptic to karyotyping in 21% of BCAs, highlighting the limitations of conventional cytogenetic approaches. At least 33.9% of BCAs resulted in gene disruption that likely contributed to the developmental phenotype, 5.2% were associated with pathogenic genomic imbalances, and 7.3% disrupted topologically associated domains (TADs) encompassing known syndromic loci. Remarkably, BCA breakpoints in eight subjects altered a single TAD encompassing MEF2C, a known driver of 5q14.3 microdeletion syndrome, resulting in decreased MEF2C expression. This study proposes that sequence-level resolution dramatically improves prediction of clinical outcomes for balanced rearrangements, and provides insight into novel pathogenic mechanisms such as altered regulation due to changes in chromosome topology. PMID:27841880

  12. Attributing runoff changes to climate variability and human activities: uncertainty analysis using four monthly water balance models

    Energy Technology Data Exchange (ETDEWEB)

    Li, Shuai; Xiong, Lihua; Li, Hong-Yi; Leung, L. Ruby; Demissie, Yonas

    2015-05-26

    Hydrological simulations to delineate the impacts of climate variability and human activities are subjected to uncertainties related to both parameter and structure of the hydrological models. To analyze the impact of these uncertainties on the model performance and to yield more reliable simulation results, a global calibration and multimodel combination method that integrates the Shuffled Complex Evolution Metropolis (SCEM) and Bayesian Model Averaging (BMA) of four monthly water balance models was proposed. The method was applied to the Weihe River Basin (WRB), the largest tributary of the Yellow River, to determine the contribution of climate variability and human activities to runoff changes. The change point, which was used to determine the baseline period (1956-1990) and human-impacted period (1991-2009), was derived using both cumulative curve and Pettitt’s test. Results show that the combination method from SCEM provides more skillful deterministic predictions than the best calibrated individual model, resulting in the smallest uncertainty interval of runoff changes attributed to climate variability and human activities. This combination methodology provides a practical and flexible tool for attribution of runoff changes to climate variability and human activities by hydrological models.

  13. Human Adaptive Mechatronics and Human-System Modelling

    Directory of Open Access Journals (Sweden)

    Satoshi Suzuki

    2013-03-01

    Full Text Available Several topics in projects for mechatronics studies, which are 'Human Adaptive Mechatronics (HAM' and 'Human-System Modelling (HSM', are presented in this paper. The main research theme of the HAM project is a design strategy for a new intelligent mechatronics system, which enhances operators' skills during machine operation. Skill analyses and control system design have been addressed. In the HSM project, human modelling based on hierarchical classification of skills was studied, including the following five types of skills: social, planning, cognitive, motion and sensory-motor skills. This paper includes digests of these research topics and the outcomes concerning each type of skill. Relationships with other research activities, knowledge and information that will be helpful for readers who are trying to study assistive human-mechatronics systems are also mentioned.

  14. Combining pathway analysis with flux balance analysis for the comprehensive study of metabolic systems.

    Science.gov (United States)

    Schilling, C H; Edwards, J S; Letscher, D; Palsson, B Ø

    The elucidation of organism-scale metabolic networks necessitates the development of integrative methods to analyze and interpret the systemic properties of cellular metabolism. A shift in emphasis from single metabolic reactions to systemically defined pathways is one consequence of such an integrative analysis of metabolic systems. The constraints of systemic stoichiometry, and limited thermodynamics have led to the definition of the flux space within the context of convex analysis. The flux space of the metabolic system, containing all allowable flux distributions, is constrained to a convex polyhedral cone in a high-dimensional space. From metabolic pathway analysis, the edges of the high-dimensional flux cone are vectors that correspond to systemically defined "extreme pathways" spanning the capabilities of the system. The addition of maximum flux capacities of individual metabolic reactions serves to further constrain the flux space and has led to the development of flux balance analysis using linear optimization to calculate optimal flux distributions. Here we provide the precise theoretical connections between pathway analysis and flux balance analysis allowing for their combined application to study integrated metabolic function. Shifts in metabolic behavior are calculated using linear optimization and are then interpreted using the extreme pathways to demonstrate the concept of pathway utilization. Changes to the reaction network, such as the removal of a reaction, can lead to the generation of suboptimal phenotypes that can be directly attributed to the loss of pathway function and capabilities. Optimal growth phenotypes are calculated as a function of environmental variables, such as the availability of substrate and oxygen, leading to the definition of phenotypic phase planes. It is illustrated how optimality properties of the computed flux distributions can be interpreted in terms of the extreme pathways. Together these developments are applied to an

  15. Nonhomeostatic control of human appetite and physical activity in regulation of energy balance.

    Science.gov (United States)

    Borer, Katarina T

    2010-07-01

    Ghrelin and leptin, putative controllers of human appetite, have no effect on human meal-to-meal appetite but respond to variations in energy availability. Nonhomeostatic characteristics of appetite and spontaneous activity stem from inhibition by leptin and ghrelin of brain reward circuit that is responsive to energy deficit, but refractory in obesity, and from the operation of a meal-timing circadian clock.

  16. Center of mass velocity-based predictions in balance recovery following pelvis perturbations during human walking

    NARCIS (Netherlands)

    Vlutters, Mark; van Asseldonk, Edwin H.F.; van der Kooij, Herman

    2016-01-01

    In many simple walking models foot placement dictates the center of pressure location and ground reaction force components, whereas humans can modulate these aspects after foot contact. Because of the differences, it is unclear to what extend predictions made by models are valid for human walking.

  17. Three-Dimensional Vestibulo-Ocular Reflex in Humans: a Matter of Balance

    NARCIS (Netherlands)

    J. Goumans (Janine)

    2010-01-01

    textabstractThe objective of this thesis was to quantify three-dimensional ocular stability in response to head movements in healthy human subjects and in patients with various types of peripheral vestibular disorders. Despite a large increase in our knowledge from animal and human studies about the

  18. The case from animal studies for balanced binocular treatment strategies for human amblyopia.

    Science.gov (United States)

    Mitchell, Donald E; Duffy, Kevin R

    2014-03-01

    Although amblyopia typically manifests itself as a monocular condition, its origin has long been linked to unbalanced neural signals from the two eyes during early postnatal development, a view confirmed by studies conducted on animal models in the last 50 years. Despite recognition of its binocular origin, treatment of amblyopia continues to be dominated by a period of patching of the non-amblyopic eye that necessarily hinders binocular co-operation. This review summarizes evidence from three lines of investigation conducted on an animal model of deprivation amblyopia to support the thesis that treatment of amblyopia should instead focus upon procedures that promote and enhance binocular co-operation. First, experiments with mixed daily visual experience in which episodes of abnormal visual input were pitted against normal binocular exposure revealed that short exposures of the latter offset much longer periods of abnormal input to allow normal development of visual acuity in both eyes. Second, experiments on the use of part-time patching revealed that purposeful introduction of episodes of binocular vision each day could be very beneficial. Periods of binocular exposure that represented 30-50% of the daily visual exposure included with daily occlusion of the non-amblyopic could allow recovery of normal vision in the amblyopic eye. Third, very recent experiments demonstrate that a short 10 day period of total darkness can promote very fast and complete recovery of visual acuity in the amblyopic eye of kittens and may represent an example of a class of artificial environments that have similar beneficial effects. Finally, an approach is described to allow timing of events in kitten and human visual system development to be scaled to optimize the ages for therapeutic interventions.

  19. Balanced Scorecard - a successful system. Integrated company management improves capability to be competitive; Balanced Scorecard - mit System zum Erfolg. Integrierte Unternehmenssteuerung verbessert Wettbewerbsfaehigkeit

    Energy Technology Data Exchange (ETDEWEB)

    Ahrend, M. [Andersen Consulting Unternehmensberatung GmbH, Muenchen (Germany); Weinrauch, M. [Andersen Consulting Unternehmensberatung GmbH, Sulzbach (Germany); Franke, V. [Andersen Consulting Unternehmensberatung GmbH, Duesseldorf (Germany)

    2000-09-18

    Balanced Scorecard is more than a reporting instrument for company management. Behind this you will find much more an integrated and already proven methodology to improve on a longterm basis the capability to be competitive. Companies in the sector of supplying economy, which are facing new challenges after the liberalization of the energy market, are in need of intelligent programmes in order to maintain on the competitive market. Balanced Scorecard combines classical financial means of control with customer- and market reference numbers as well as information on the process navigation and staff management. It links strategy planning and the strategy targets of a utility with its operational business. (orig.) [German] Balanced Scorecard ist mehr als ein Reporting-Instrument fuer das Unternehmensmanagement. Dahinter verbirgt sich vielmehr eine integrierte und bereits bewaehrte Methodik zur nachhaltigen Verbesserung der Wettbewerbsfaehigkeit. Unternehmen der Versorgungswirtschaft, die nach der Liberalisierung des Energiemarkts vor neuen Herausforderungen stehen, beduerfen intelligenter Konzepte, um sich im Wettbewerb behaupten zu koennen. Die Balanced Scorecard verknuepft klassische finanzielle Steuerungsgroessen mit Kunden- und Marktkennzahlen sowie Informationen der Prozesssteuerung und Mitarbeiterfuehrung. Mit ihr gelingt es, die oft bestehende Luecke zwischen strategischen Zielen und operativen Massnahmen zu schliessen. (orig.)

  20. Global classical solutions for partially dissipative hyperbolic system of balance laws

    CERN Document Server

    Xu, Jiang

    2012-01-01

    This work is concerned with ($N$-component) hyperbolic system of balance laws in arbitrary space dimensions. Under entropy dissipative assumption and the Shizuta-Kawashima algebraic condition, a general theory on the well-posedness of classical solutions in the framework of Chemin-Lerner's spaces with critical regularity is established. To do this, we first explore the functional space theory and develop an elementary fact that indicates the relation between homogeneous and inhomogeneous Chemin-Lerner's spaces. Then this fact allows to prove the local well-posedness for general data and global well-posedness for small data by using the Fourier frequency-localization argument. Finally, we apply the new existence theory to a specific fluid model-the compressible Euler equations with damping, and obtain the corresponding results in critical spaces.

  1. Health technology assessment in the Balkans: opportunities for a balanced drug assessment system.

    Science.gov (United States)

    Dankó, Dávid; Petrova, Guenka

    2014-11-02

    Countries in the Balkan region use pharmaco-economic data for decisions about the inclusion of new pharmaceuticals into their positive drug lists, but no predefined frameworks are used and resources for health technology assessment (HTA) are limited. The goal of this analysis is to investigate into possible development directions for the HTA system in the region, and provide some practical recommendations for a sustainable model. For this purpose, the main factors currently influencing HTA in Balkan countries are briefly presented, and possible development strategies are compared. A resource-saving balanced assessment approach is proposed. It is aligned with available resources and capabilities, and helps access to new pharmaceuticals while ensuring the transparency of decision-making processes and the stability of the pharmaceutical budget.

  2. Low complexity transmit antenna selection with power balancing in OFDM systems

    KAUST Repository

    Park, Kihong

    2010-10-01

    In this paper, we consider multi-carrier systems with multiple transmit antennas under the power balancing constraint, which is defined as the constraint that the power on each antenna should be limited under a certain level due to the linearity of the power amplifier of the RF chain. Applying transmit antenna selection and fixed-power variable-rate transmission per subcarrier as a function of channel variations, we propose an implementation-friendly antenna selection method which offers a reduced complexity in comparison with the optimal antenna selection scheme. More specifically, in order to solve the subcarrier imbalance across the antennas, we operate a two-step reallocation procedure to minimize the loss of spectral efficiency. We also provide an analytic lower bound on the spectral efficiency for the proposed scheme. From selected numerical results, we show that our suboptimal scheme offers almost the same spectral efficiency as the optimal one. © 2010 IEEE.

  3. The Human-Robot Interaction Operating System

    Science.gov (United States)

    Fong, Terrence; Kunz, Clayton; Hiatt, Laura M.; Bugajska, Magda

    2006-01-01

    In order for humans and robots to work effectively together, they need to be able to converse about abilities, goals and achievements. Thus, we are developing an interaction infrastructure called the "Human-Robot Interaction Operating System" (HRI/OS). The HRI/OS provides a structured software framework for building human-robot teams, supports a variety of user interfaces, enables humans and robots to engage in task-oriented dialogue, and facilitates integration of robots through an extensible API.

  4. Setup time reduction: SMED-balancing integrated model for manufacturing systems with automated transfer

    Directory of Open Access Journals (Sweden)

    Maurizio Faccio

    2013-10-01

    Full Text Available The importance of short setup times is increasing in every type of industry. It has been known how to address this problem for about 20 years. The SMED method, originally developed by the Japanese industrial engineer Shigeo Shingo for reducing the time to exchange dies, gives a really straightforward approach to improve existing setups. On the other hand, in the case of complex manufacturing systems the simple application of the SMED methodology is not enough. Manufacturing systems composed of different working machines with automated transfer facilities are a good example. Technologicalconstraints, task precedence constraints, and synchronization between different setup tasks are just some of the influencing factors that make an improved SMED desirable. The present paper, starting from an industrial case, aims to provide a heuristics methodology that integrates the traditional SMED with the workload balancing problem that is typical of assembly systems, in order to address the setup reduction problem in the case of complex manufacturing systems. Anindustrial case is reported to validate the proposed model and to demonstrate its practical implications.

  5. Toward a workable biosafety system for regulating genetically modified organisms in Ethiopia: balancing conservation and competitiveness.

    Science.gov (United States)

    Abraham, Adane

    2013-01-01

    On September 9, 2009, Ethiopia enacted a highly restrictive biosafety law firmly based on precautionary principles as a foundation for its GMO regulation system. Its drafting process, led by the country's Environmental Protection Authority, was judged as biased, focusing only on protecting the environment from perceived risks, giving little attention to potential benefits of GMOs. Many of its provisions are very stringent, exceeding those of Cartagena Protocol on Biosafety, while others cannot be fulfilled by applicants, collectively rendering the emerged biosafety system unworkable. These provisions include requirements for advance informed agreement and rigorous socioeconomic assessment in risk evaluation for all GMO transactions, including contained research use-which requires the head of the competent national authority of the exporting country to take full responsibility for GMO-related information provided-and stringent labeling, insurance and monitoring requirements for all GMO activities. Furthermore, there is no provision to establish an independent national biosafety decision-making body(ies). As a result, foreign technology owners that provide highly demanded technologies like Bt cotton declined to work with Ethiopia. There is a fear that the emerged biosafety system might also continue to suppress domestic genetic engineering research and development. Thus, to benefit from GMOs, Ethiopia has to revise its biosafety system, primarily by making changes to some provisions of the law in a way that balances its diverse interests of conserving biodiversity, protecting the environment and enhancing competition in agricultural and other economic sectors.

  6. Balancing selfishness and prosociality can enhance the resilience of human groups

    CERN Document Server

    Realpe-Gómez, John; Nardin, Gustavo; Montoya, Javier Antonio

    2016-01-01

    Cooperation among humans is crucial for overcoming some of the most pressing social challenges of our time like climate change, financial crises, and over exploitation of natural resources. While several mechanisms of self-governance for supporting cooperation, such as peer punishment, reciprocity, and social norms have been extensively explored, the impact of cooperation on the ability of human groups to absorb changes and still persist, their resilience, has received less attention. Here we develop an analytically-tractable model that incorporates both selfish and prosocial aspects as constituents of cooperative decision making, which quantitatively reproduce findings from recent large scale experiments on cooperation with humans. The model parameters inferred from experimental data are near a line of critical points, which suggests a way in which cooperation can be sustained and impact the resilience of human groups to external variability.

  7. Land use change around protected areas: management to balance human needs and ecological function.

    Science.gov (United States)

    DeFries, Ruth; Hansen, Andrew; Turner, B L; Reid, Robin; Liu, Jianguo

    2007-06-01

    Protected areas throughout the world are key for conserving biodiversity, and land use is key for providing food, fiber, and other ecosystem services essential for human sustenance. As land use change isolates protected areas from their surrounding landscapes, the challenge is to identify management opportunities that maintain ecological function while minimizing restrictions on human land use. Building on the case studies in this Invited Feature and on ecological principles, we identify opportunities for regional land management that maintain both ecological function in protected areas and human land use options, including preserving crucial habitats and migration corridors, and reducing dependence of local human populations on protected area resources. Identification of appropriate and effective management opportunities depends on clear definitions of: (1) the biodiversity attributes of concern; (2) landscape connections to delineate particular locations with strong ecological interactions between the protected area and its surrounding landscape; and (3) socioeconomic dynamics that determine current and future use of land resources in and around the protected area.

  8. Shaped and Balanced by Hormones : cortisol, testosterone and the psychoneuroendocrinology of human socio-emotional behavior

    NARCIS (Netherlands)

    Montoya, E.R.

    2015-01-01

    The steroid hormones testosterone and cortisol can be considered hormones for environmental challenges; they are involved in adaptive neural and behavioral responses towards emotional stimuli. A key challenge of human psychoneuroendocrinology is to unravel the neural mechanisms by which testosterone

  9. Results of monitoring large carbon fiber post-tensioning systems in a balanced Cantilever Brdige (Dintelharbour Bridge, The Netherlands)

    NARCIS (Netherlands)

    Vervuurt, A.H.J.M.; Kaptijn, N.; Hageman, J.G.; Kuilboer, C.P.M.

    2012-01-01

    Steel post-tensioning systems and stay cables are susceptible to corrosion. Carbon fiber systems are not. However, there was no experience on the long term behavior of such post-tensioned elements. Four external tendons (75 m long), stressed to a load of 2650 kN, were applied in a large balanced can

  10. Results of monitoring large carbon fiber post-tensioning systems in a balanced Cantilever Brdige (Dintelharbour Bridge, The Netherlands)

    NARCIS (Netherlands)

    Vervuurt, A.H.J.M.; Kaptijn, N.; Hageman, J.G.; Kuilboer, C.P.M.

    2012-01-01

    Steel post-tensioning systems and stay cables are susceptible to corrosion. Carbon fiber systems are not. However, there was no experience on the long term behavior of such post-tensioned elements. Four external tendons (75 m long), stressed to a load of 2650 kN, were applied in a large balanced

  11. Biological Systems, Energy Sources, and Biology Teaching. Biology and Human Welfare.

    Science.gov (United States)

    Tribe, Michael; Pritchard, Alan J.

    This five-chapter document (part of a series on biology and human welfare) focuses on biological systems as energy sources and on the teaching of this subject area. Chapter 1 discusses various topics related to energy and ecology, including biomass, photosynthesis and world energy balances, energy flow through ecosystems, and others. Chapter 2…

  12. The emerging role of the endocannabinoid system in endocrine regulation and energy balance.

    Science.gov (United States)

    Pagotto, Uberto; Marsicano, Giovanni; Cota, Daniela; Lutz, Beat; Pasquali, Renato

    2006-02-01

    During the last few years, the endocannabinoid system has emerged as a highly relevant topic in the scientific community. Many different regulatory actions have been attributed to endocannabinoids, and their involvement in several pathophysiological conditions is under intense scrutiny. Cannabinoid receptors, named CB1 receptor and CB2 receptor, first discovered as the molecular targets of the psychotropic component of the plant Cannabis sativa, participate in the physiological modulation of many central and peripheral functions. CB2 receptor is mainly expressed in immune cells, whereas CB1 receptor is the most abundant G protein-coupled receptor expressed in the brain. CB1 receptor is expressed in the hypothalamus and the pituitary gland, and its activation is known to modulate all the endocrine hypothalamic-peripheral endocrine axes. An increasing amount of data highlights the role of the system in the stress response by influencing the hypothalamic-pituitary-adrenal axis and in the control of reproduction by modifying gonadotropin release, fertility, and sexual behavior. The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions. The endocannabinoid system modulates rewarding properties of food by acting at specific mesolimbic areas in the brain. In the hypothalamus, CB1 receptor and endocannabinoids are integrated components of the networks controlling appetite and food intake. Interestingly, the endocannabinoid system was recently shown to control metabolic functions by acting on peripheral tissues, such as adipocytes, hepatocytes, the gastrointestinal tract, and, possibly, skeletal muscle. The relevance of the system is further strenghtened by the notion that drugs interfering with the activity of the endocannabinoid system are considered as promising candidates for the treatment of various diseases

  13. Human capital and its spatial distribution as limiting factors for the balanced development of Serbia

    Directory of Open Access Journals (Sweden)

    Jokić Vesna

    2015-01-01

    Full Text Available Human capital is one of the key factors of economic and social development. Namely, the growth potential of a territory is largely dependent on human capital that is, on citizen’s creative potential and especially on their education. Society with a better endowment of human capital has a greater development potential. The subject of this paper is Serbia’s human capital seen from the point of view of workforce education structure (20-64 age group. In this paper we present spatial distribution of workforce, i.e. the differences in workforce education levels and polarization of Serbian territory in terms of human capital pool. The result is a typology of municipalities in Serbia based on calculated values of average completed education level - the EMN index. Mapping of the corresponding values was done at the municipality level in order to get a clear distinction and a more accurate picture of spatial disparities in human resources. [Projekat Ministarstva nauke Republike Srbije, br. III47014: The Role and Implementation of the National Spatial Plan and Regional Development Documents in Renewal of Strategic Research, Thinking and Governance in Serbia

  14. The functional assessment Berg Balance Scale is better capable of estimating fall risk in the elderly than the posturographic Balance Stability System A avaliação funcional Berg Balance Scale é capaz de estimar melhor o risco de quedas em idosos do que a posturografia Balance Stability System

    Directory of Open Access Journals (Sweden)

    Vanessa Vieira Pereira

    2013-01-01

    Full Text Available The purpose of this study was to verify which instrument better identifies recurrent falls in the elderly. Ninety-eight old people, with an average age of 80±4 years, were submitted to an assessment of balance and fall risk by means of the Berg Balance Scale (BBS and the posturographic Balance Stability System (BSS. The BBS was correlated with the BSS (r=-0.27; p=0.008, age (r=-0.38; pA proposta do estudo foi verificar o instrumento que melhor identifica o risco de quedas recorrentes em idosos. O estudo incluiu 98 idosos, com média de idade de 80±4 anos, submetidos à avaliação do equilíbrio e risco de quedas por meio da Berg Balance Scale (BBS e da posturografia Balance Stability System (BSS. A BBS foi correlacionada com a BSS (r=-0,27; p=0,008, com a idade (r=-0,38; p<0,001 e com o número de quedas (r=-0,25; p=0,013. A análise de regressão logística mostrou que idosos classificados com risco de quedas na BBS apresentaram 2,5 (95%IC 1,08-5,78 mais chances de identificar quem teve duas quedas ou mais no último ano. A BBS identificou que quanto maior a idade pior é o equilíbrio funcional e demonstrou maior capacidade de identificar o risco de quedas sofridas no último ano quando comparada a BSS.

  15. Problems of application of the balanced system of indicators on domestic enterprises

    Directory of Open Access Journals (Sweden)

    O.S. Savchenko

    2011-01-01

    Full Text Available The article is dedicated to theoretical and methodical basics of the implementation of Balanced Scorecard in business organization. There were fundamental problems, advantages and disadvantages defined by the authors; methodical approaches to the choice of strategies and stages of formation and introduction of Balanced Scorecard analyzed; essential principles of development of key performance indicators for building-up of Balanced Scorecard formulated.

  16. Uplink Downlink Rate Balancing and Throughput Scaling in FDD Massive MIMO Systems

    Science.gov (United States)

    Bergel, Itsik; Perets, Yona; Shamai, Shlomo

    2016-05-01

    In this work we extend the concept of uplink-downlink rate balancing to frequency division duplex (FDD) massive MIMO systems. We consider a base station with large number antennas serving many single antenna users. We first show that any unused capacity in the uplink can be traded off for higher throughput in the downlink in a system that uses either dirty paper (DP) coding or linear zero-forcing (ZF) precoding. We then also study the scaling of the system throughput with the number of antennas in cases of linear Beamforming (BF) Precoding, ZF Precoding, and DP coding. We show that the downlink throughput is proportional to the logarithm of the number of antennas. While, this logarithmic scaling is lower than the linear scaling of the rate in the uplink, it can still bring significant throughput gains. For example, we demonstrate through analysis and simulation that increasing the number of antennas from 4 to 128 will increase the throughput by more than a factor of 5. We also show that a logarithmic scaling of downlink throughput as a function of the number of receive antennas can be achieved even when the number of transmit antennas only increases logarithmically with the number of receive antennas.

  17. Autonomic Nervous System in the Control of Energy Balance and Body Weight: Personal Contributions

    Directory of Open Access Journals (Sweden)

    G. Messina

    2013-01-01

    Full Text Available The prevalence of obesity is increasing in the industrialized world, so that the World Health Organization considers obesity as a “pandemia” in rich populations. The autonomic nervous system plays a crucial role in the control of energy balance and body weight. This review summarizes our own data and perspectives, emphasizing the influence exerted by autonomic nervous system on energy expenditure and food intake, which are able to determine the body weight. Activation of the sympathetic discharge causes an increase in energy expenditure and a decrease in food intake, while reduction of food intake and body weight loss determines a reduction of the sympathetic activity. On the other hand, pathophysiological mechanisms of the obesity involve alterations of the sympathetic nervous system in accordance with the “Mona Lisa Hypothesis,” an acronym for “most obesities known are low in sympathetic activity.” Furthermore, the parasympathetic influences on the energy expenditure are analyzed in this review, showing that an increase in parasympathetic activity can induce a paradoxical enhancement of energy consumption.

  18. Autonomic nervous system in the control of energy balance and body weight: personal contributions.

    Science.gov (United States)

    Messina, G; De Luca, V; Viggiano, An; Ascione, A; Iannaccone, T; Chieffi, S; Monda, M

    2013-01-01

    The prevalence of obesity is increasing in the industrialized world, so that the World Health Organization considers obesity as a "pandemia" in rich populations. The autonomic nervous system plays a crucial role in the control of energy balance and body weight. This review summarizes our own data and perspectives, emphasizing the influence exerted by autonomic nervous system on energy expenditure and food intake, which are able to determine the body weight. Activation of the sympathetic discharge causes an increase in energy expenditure and a decrease in food intake, while reduction of food intake and body weight loss determines a reduction of the sympathetic activity. On the other hand, pathophysiological mechanisms of the obesity involve alterations of the sympathetic nervous system in accordance with the "Mona Lisa Hypothesis," an acronym for "most obesities known are low in sympathetic activity." Furthermore, the parasympathetic influences on the energy expenditure are analyzed in this review, showing that an increase in parasympathetic activity can induce a paradoxical enhancement of energy consumption.

  19. Configuring balanced scorecards for measuring health system performance: evidence from 5 years' evaluation in Afghanistan.

    Science.gov (United States)

    Edward, Anbrasi; Kumar, Binay; Kakar, Faizullah; Salehi, Ahmad Shah; Burnham, Gilbert; Peters, David H

    2011-07-01

    In 2004, Afghanistan pioneered a balanced scorecard (BSC) performance system to manage the delivery of primary health care services. This study examines the trends of 29 key performance indicators over a 5-year period between 2004 and 2008. Independent evaluations of performance in six domains were conducted annually through 5,500 patient observations and exit interviews and 1,500 provider interviews in >600 facilities selected by stratified random sampling in each province. Generalized estimating equation (GEE) models were used to assess trends in BSC parameters. There was a progressive improvement in the national median scores scaled from 0-100 between 2004 and 2008 in all six domains: patient and community satisfaction of services (65.3-84.5, pperformance benchmarking during the 5-year period. However, scorecard reconfigurations are needed to integrate effectiveness and efficiency measures and accommodate changes in health systems policy and strategy architecture to ensure its continued relevance and effectiveness as a comprehensive health system performance measure. The process of BSC design and implementation can serve as a valuable prototype for health policy planners managing performance in similar health care contexts. Please see later in the article for the Editors' Summary.

  20. A nonlinearity in permanent-magnet systems used in watt balances

    CERN Document Server

    Li, Shisong; Pratt, Jon

    2014-01-01

    Watt balances are used to measure the Planck constant and will be used in the future to realize mass at the kilogram level. They increasingly rely on permanent magnet systems to generate the magnetic flux. It has been known that the weighing current might effect the magnetization state of the permanent magnetic system used in these systems causing a systematic bias that can lead to an error in the result if not accounted for. In this article a simple model explaining the effect of the weighing current on the yoke of the magnet is developed. This model leads to a nonlinear dependence of the magnetic flux density in the gap that is proportional to the squared value of the coil current. The effect arises from changing the reluctance of the yoke by the additional field produced by the coil. Our analysis shows that the effect depends on the width of the air gap, the magnetic flux density in the air gap, and the $BH$ curve of the yoke material. Suggestions to reduce the nonlinear effect are discussed.

  1. Configuring Balanced Scorecards for Measuring Health System Performance: Evidence from 5 Years' Evaluation in Afghanistan

    Science.gov (United States)

    Edward, Anbrasi; Kumar, Binay; Kakar, Faizullah; Salehi, Ahmad Shah; Burnham, Gilbert; Peters, David H.

    2011-01-01

    Background In 2004, Afghanistan pioneered a balanced scorecard (BSC) performance system to manage the delivery of primary health care services. This study examines the trends of 29 key performance indicators over a 5-year period between 2004 and 2008. Methods and Findings Independent evaluations of performance in six domains were conducted annually through 5,500 patient observations and exit interviews and 1,500 provider interviews in >600 facilities selected by stratified random sampling in each province. Generalized estimating equation (GEE) models were used to assess trends in BSC parameters. There was a progressive improvement in the national median scores scaled from 0–100 between 2004 and 2008 in all six domains: patient and community satisfaction of services (65.3–84.5, pperformance benchmarking during the 5-year period. However, scorecard reconfigurations are needed to integrate effectiveness and efficiency measures and accommodate changes in health systems policy and strategy architecture to ensure its continued relevance and effectiveness as a comprehensive health system performance measure. The process of BSC design and implementation can serve as a valuable prototype for health policy planners managing performance in similar health care contexts. Please see later in the article for the Editors' Summary PMID:21814499

  2. Learning an intermittent control strategy for postural balancing using an EMG-based human-computer interface.

    Directory of Open Access Journals (Sweden)

    Yoshiyuki Asai

    Full Text Available It has been considered that the brain stabilizes unstable body dynamics by regulating co-activation levels of antagonist muscles. Here we critically reexamined this established theory of impedance control in a postural balancing task using a novel EMG-based human-computer interface, in which subjects were asked to balance a virtual inverted pendulum using visual feedback information on the pendulum's position. The pendulum was actuated by a pair of antagonist joint torques determined in real-time by activations of the corresponding pair of antagonist ankle muscles of subjects standing upright. This motor-task raises a frustrated environment; a large feedback time delay in the sensorimotor loop, as a source of instability, might favor adopting the non-reactive, preprogrammed impedance control, but the ankle muscles are relatively hard to co-activate, which hinders subjects from adopting the impedance control. This study aimed at discovering how experimental subjects resolved this frustrated environment through motor learning. One third of subjects adapted to the balancing task in a way of the impedance-like control. It was remarkable, however, that the majority of subjects did not adopt the impedance control. Instead, they acquired a smart and energetically efficient strategy, in which two muscles were inactivated simultaneously at a sequence of optimal timings, leading to intermittent appearance of periods of time during which the pendulum was not actively actuated. Characterizations of muscle inactivations and the pendulum¡Çs sway showed that the strategy adopted by those subjects was a type of intermittent control that utilizes a stable manifold of saddle-type unstable upright equilibrium that appeared in the state space of the pendulum when the active actuation was turned off.

  3. Learning an intermittent control strategy for postural balancing using an EMG-based human-computer interface.

    Science.gov (United States)

    Asai, Yoshiyuki; Tateyama, Shota; Nomura, Taishin

    2013-01-01

    It has been considered that the brain stabilizes unstable body dynamics by regulating co-activation levels of antagonist muscles. Here we critically reexamined this established theory of impedance control in a postural balancing task using a novel EMG-based human-computer interface, in which subjects were asked to balance a virtual inverted pendulum using visual feedback information on the pendulum's position. The pendulum was actuated by a pair of antagonist joint torques determined in real-time by activations of the corresponding pair of antagonist ankle muscles of subjects standing upright. This motor-task raises a frustrated environment; a large feedback time delay in the sensorimotor loop, as a source of instability, might favor adopting the non-reactive, preprogrammed impedance control, but the ankle muscles are relatively hard to co-activate, which hinders subjects from adopting the impedance control. This study aimed at discovering how experimental subjects resolved this frustrated environment through motor learning. One third of subjects adapted to the balancing task in a way of the impedance-like control. It was remarkable, however, that the majority of subjects did not adopt the impedance control. Instead, they acquired a smart and energetically efficient strategy, in which two muscles were inactivated simultaneously at a sequence of optimal timings, leading to intermittent appearance of periods of time during which the pendulum was not actively actuated. Characterizations of muscle inactivations and the pendulum¡Çs sway showed that the strategy adopted by those subjects was a type of intermittent control that utilizes a stable manifold of saddle-type unstable upright equilibrium that appeared in the state space of the pendulum when the active actuation was turned off.

  4. BALANCED SCORECARDS EVALUATION MODEL THAT INCLUDES ELEMENTS OF ENVIRONMENTAL MANAGEMENT SYSTEM USING AHP MODEL

    Directory of Open Access Journals (Sweden)

    Jelena Jovanović

    2010-03-01

    Full Text Available The research is oriented on improvement of environmental management system (EMS using BSC (Balanced Scorecard model that presents strategic model of measurem ents and improvement of organisational performance. The research will present approach of objectives and environmental management me trics involvement (proposed by literature review in conventional BSC in "Ad Barska plovi dba" organisation. Further we will test creation of ECO-BSC model based on business activities of non-profit organisations in order to improve envir onmental management system in parallel with other systems of management. Using this approach we may obtain 4 models of BSC that includ es elements of environmen tal management system for AD "Barska plovidba". Taking into acc ount that implementation and evaluation need long period of time in AD "Barska plovidba", the final choice will be based on 14598 (Information technology - Software product evaluation and ISO 9126 (Software engineering - Product quality using AHP method. Those standards are usually used for evaluation of quality software product and computer programs that serve in organisation as support and factors for development. So, AHP model will be bas ed on evolution criteria based on suggestion of ISO 9126 standards and types of evaluation from two evaluation teams. Members of team & will be experts in BSC and environmental management system that are not em ployed in AD "Barska Plovidba" organisation. The members of team 2 will be managers of AD "Barska Plovidba" organisation (including manage rs from environmental department. Merging results based on previously cr eated two AHP models, one can obtain the most appropriate BSC that includes elements of environmental management system. The chosen model will present at the same time suggestion for approach choice including ecological metrics in conventional BSC model for firm that has at least one ECO strategic orientation.

  5. Stupid Tutoring Systems, Intelligent Humans

    Science.gov (United States)

    Baker, Ryan S.

    2016-01-01

    The initial vision for intelligent tutoring systems involved powerful, multi-faceted systems that would leverage rich models of students and pedagogies to create complex learning interactions. But the intelligent tutoring systems used at scale today are much simpler. In this article, I present hypotheses on the factors underlying this development,…

  6. The Surface Energy Balance System(sebs) For Estimating Energy Balance At Regional Scale - A Validation Using Atsr and Scintillometer Measurements and Racmo Pbl Variables

    Science.gov (United States)

    Jia, L.; Su, Z.; van den Hurk, B.; Moene, A. F.; Menenti, M.

    The estimation of atmospheric turbulent fluxes at the land surface has long been rec- ognized as the most important process in the determination of the exchanges of energy and mass among hydrosphere, atmosphere and biosphere. Remote sensing is probably the only technique which can provide representative measurements of several relevant physical parameters at scales from a point to a continent. Techniques using remote sensing information to estimate atmospheric turbulent fluxes are therefore essential when dealing with processes that can not be represented only by point measurements. In this contribution the Surface Energy Balance System (SEBS) for the estimation of atmospheric turbulent fluxes using satellite earth observation data are evaluated with measurements of sensible heat fluxes by scintillometry. SEBS as proposed here consists of: 1) a set of tools for the determination of the land surface physical param- eters, such as albedo, emissivity, temperature, vegetation coverage etc. from spectral reflectance and radiance of ATSR-2 measurements; 2) an extended model for the de- termination of the roughness length for heat transfer; 3) and a new formulation for the determination of the evaporative fraction on the basis of energy balance at lim- iting cases. The input to SEBS are ATSR derived surface physical variables and at- mospheric boundary layer variables derived from the mesoscale atmospheric model RACMO. The SEBS estimates are satisfactory when evaluated over three different land surface areas with dry, small irrigated and larger irrigated surface situations re- spectively.

  7. The immediate effects of ankle balance taping with kinesiology tape on ankle active range of motion and performance in the Balance Error Scoring System.

    Science.gov (United States)

    Lee, Sun-Min; Lee, Jung-Hoon

    2017-05-01

    This study investigated the changes in ankle active range of motion (AROM) and performance on the Balance Error Scoring System (BESS) in cases in which no tape, placebo taping or ankle balance taping (ABT) with kinesiology tape was used. Randomized cross-over trial. University laboratory. Fifteen physically active individuals (7 men, 8 women). Postural control was assessed based on performances on the BESS. Active ankle flexibility was assessed by measuring the ankle AROM of both ankles under each taping condition in a random order at 1-week intervals. The ankle AROM among the taping conditions were not significantly different. There were no significant differences in the error scores of single-leg and tandem stances on a firm surface among the taping conditions. Compared to those obtained in the absence of taping, the error scores of the single-leg and tandem stances on a foam surface were significantly lower with ABT, but they did not significantly differ from the placebo taping scores. This study showed that ABT with kinesiology tape immediately improved postural control on unstable surfaces without changes in ankle AROM. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Linking Economic Value Added, Direct Costing, and the Lean Thinking to the Balanced Scorecard in a System Dynamics Modelling Approach

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

     Purpose - To show how three practices normally applied separately can be linked to support the strategy evaluation and the performance measurement in the balanced scorecard. Recent studies, e.g. Kaplan and Norton [Using the Balanced Scorecard as a Strategic Management System, Harvard Business...... Review, July-August, 2007], provide evidence that companies fail to see the possible benefits of combining and integrating several accounting practices into a single framework. Design/methodology/approach - We use a System Dynamics Modelling approach to the BSC-thinking. The BSC model includes the five...

  9. Hybrid Battery Ultracapacitor System For Human Robotic Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this proposal is to develop a hybrid battery-ultra capacitor storage system that powers human-robotic systems in space missions. Space missions...

  10. Genetic Diversity and Balancing Selection within the Human Phenylalanine Hydroxylase (PAH Gene Region in Iranian Population

    Directory of Open Access Journals (Sweden)

    J Mowla

    2012-04-01

    Full Text Available Background:Genetic diversity of three polymorphic markers in the phenylalanine hydroxylase(PAH gene region including PvuII(a, PAHSTR and MspI were investigated.Methods:Unrelated individuals (n=139 from the Iranian populations were genotyped using primers specific to PAH gene markers including PvuII(a,MspI and PAHSTR. The amplified products for PvuII(a,MspI were digested using the appropriate restriction enzymes and separated on 1.5% agarose. The PAHSTR alleles were identified using polyacrylamide gel electrophoresis followed by silver staining. The exact size of the STR alleles was determined by sequencing. The allele frequency and population status of the alleles were estimated using PHASE, FBAT and GENEPOP software.Results: The estimated degree of heterozygosity for PAHSTR, MspI and PvuII (a was 66%, 56% and 58%, respectively. The haplotype estimation analysis of the markers resulted in nine informative haplotypes with frequencies ≥5%.Moreover,the results obtained from Ewens-Watterson test for neutrality suggested that the markers were under balancing selection in the Iranian population.Conclusion:These findings suggested the presence of genetic diversity at these three markers in the PAH gene region. Therefore, the markers could be considered as functional markers for linkage analysis of the PAH gene mutations in the Iranian families with the PKU disease.

  11. The benefits of using a vacuum-assisted socket system to improve balance and gait in elderly transtibial amputees.

    Science.gov (United States)

    Samitier, C Beatriz; Guirao, Lluis; Costea, Maria; Camós, Josep M; Pleguezuelos, Eulogio

    2016-02-01

    Lower limb amputation leads to impaired balance, ambulation, and transfers. Proper fit of the prosthesis is a determining factor for successful ambulation. Vacuum-assisted socket systems extract air from the socket, which decreases pistoning and probability of soft-tissue injuries and increases proprioception and socket comfort. To investigate the effect of vacuum-assisted socket system on transtibial amputees' performance-based and perceived balance, transfers, and gait. Quasi-experimental before-and-after study. Subjects were initially assessed using their prosthesis with the regular socket and re-evaluated 4 weeks after fitting including the vacuum-assisted socket system. We evaluated the mobility grade using Medicare Functional Classification Level, Berg Balance Scale, Four Square Step Test, Timed Up and Go Test, the 6-Min Walk Test, the Locomotor Capabilities Index, Satisfaction with Prosthesis (SAT-PRO questionnaire), and Houghton Scale. A total of 16 unilateral transtibial dysvascular amputees, mean age 65.12 (standard deviation = 10.15) years. Using the vacuum-assisted socket system, the patients significantly improved in balance, gait, and transfers: scores of the Berg Balance Scale increased from 45.75 (standard deviation = 6.91) to 49.06 (standard deviation = 5.62) (p balance, gait, and transfers in over-50-year-old dysvascular transtibial amputees. This study gives more insight into the use of vacuum-assisted socket systems to improve elderly transtibial dysvascular amputees' functionality and decrease their risk of falls. The use of an additional distal valve in the socket should be considered in patients with a lower activity level. © The International Society for Prosthetics and Orthotics 2014.

  12. NASA Human System Risk Assessment Process

    Science.gov (United States)

    Francisco, D.; Romero, E.

    2016-01-01

    NASA utilizes an evidence based system to perform risk assessments for the human system for spaceflight missions. The center of this process is the multi-disciplinary Human System Risk Board (HSRB). The HSRB is chartered from the Chief Health and Medical Officer (OCHMO) at NASA Headquarters. The HSRB reviews all human system risks via an established comprehensive risk and configuration management plan based on a project management approach. The HSRB facilitates the integration of human research (terrestrial and spaceflight), medical operations, occupational surveillance, systems engineering and many other disciplines in a comprehensive review of human system risks. The HSRB considers all factors that influence human risk. These factors include pre-mission considerations such as screening criteria, training, age, sex, and physiological condition. In mission factors such as available countermeasures, mission duration and location and post mission factors such as time to return to baseline (reconditioning), post mission health screening, and available treatments. All of the factors influence the total risk assessment for each human risk. The HSRB performed a comprehensive review of all potential inflight medical conditions and events and over the course of several reviews consolidated the number of human system risks to 30, where the greatest emphasis is placed for investing program dollars for risk mitigation. The HSRB considers all available evidence from human research and, medical operations and occupational surveillance in assessing the risks for appropriate mitigation and future work. All applicable DRMs (low earth orbit for 6 and 12 months, deep space for 30 days and 1 year, a lunar mission for 1 year, and a planetary mission for 3 years) are considered as human system risks are modified by the hazards associated with space flight such as microgravity, exposure to radiation, distance from the earth, isolation and a closed environment. Each risk has a summary

  13. Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection

    Science.gov (United States)

    Exposure to oxidant air pollution is associated with Increased respiratory morbiditses and susceptibility to Infections Ozone is a commonly encountered oxidant air pollutant, yet Its effects on influenza infections in humans are not known ‘the greater Mexico City area was the pri...

  14. Balancing the needs and preferences of humans against concerns for fishes

    DEFF Research Database (Denmark)

    Sandøe, Peter; Gamborg, Christian; Kadri, S.

    2009-01-01

    How can stakeholders within the fisheries community engage in constructive ethical discussions? Drawing on experiences from previous debates surrounding the human use of animals, this paper presents a proactive approach whereby stakeholders can create a framework for ethical discussion of capture...

  15. Study on Virtual Human Skeleton System

    Institute of Scientific and Technical Information of China (English)

    郭巧; 李亦

    2004-01-01

    A solution of virtual human skeleton system is proposed. Some issues on integration of anatomical geometry, biodynamics and computer animation are studied. The detailed skeleton system model that incorporates the biodynamic and geometric characteristics of a human skeleton system allows some performance studies in greater detail than that performed before. It may provide an effective and convenient way to analyze and evaluate the movement performance of a human body when the personalized anatomical data are used in the models. An example shows that the proposed solution is effective for the stated problems.

  16. The human growth and the healthy environment as a condition of balanced development for the course of human.

    Directory of Open Access Journals (Sweden)

    I. Koukoumpliakos

    2008-01-01

    Full Text Available The rising standard of living has evoked an important burden in the natural environment leading to an immense deterioration of nature. The pollution of the atmosphere and seas, the industrial waste, the climatic changes, the chaotic built-up extension threaten the health of all of us. The responsibility for the pollution of the environment is allocated in everybody. The State is accountable not only for the political planning and the policy that practises, but also for the frame it shapes for the citizens to follow. The improvement of the quality of environment must be combined with the economic progress and growth. The intensity of environmental problems worries the International Community, while the saving and growth of new green forms of energy appear as imperative need. We find already ourselves in a progressive but continuous growth, which has the conditions to develop in the future with spectacular rhythm.The methodology of present work is recommended for: a bibliographic research, mainly Greek, b comparison of the facts that are exported from research, connecting them with the given facts. This comparison leads to the necessary coexistence of a healthy environment and a viable growth.In the results of the research the essential conditions of coexistence are presented between these two. Thus we realise that: a the configuration of an evener environmental conscience is required via the education which would guarantee the balanced and sustainable growth, b the change of perception of people as lords of nature is considered necessary and its replacement by the awareness that the nature does not constitute an inexhaustible resource.With that in mind we conclude that: a the research is required to lead to alternative sources of energy such as the creation of Aeolian parks. It is estimated that more investments in other types of renewable sources of energy such as geothermal and hydroelectric can constitute also advisable solutions. The use of

  17. Multi-Objective Control of Balancing Systems for Li-Ion Battery Packs

    DEFF Research Database (Denmark)

    Barreras, Jorge Varela; Pinto, Claudio; de Castro, Ricardo;

    2014-01-01

    While a great number of battery balancing circuit topologies have been proposed, the unique control objective typically pursued is equalization of single cell charge. However, a balancing circuit could offer potentially more control features, especially with topologies able to provide bidirection...

  18. Balancing priorities

    DEFF Research Database (Denmark)

    Mønsted, Troels; Johansen, Andreas Kaas; Lauridsen, Frederik Vahr Bjarnø

    2016-01-01

    a heterogeneous ensemble of care providers. In this paper, we present findings from a field study of coordinative work in distributed elder care in Denmark. The purpose of this study is to further our understanding of the coordinative challenges of distributed elder care, and to inform design of new care......, that are needed by the healthcare system, but also the work involved in balancing priorities....

  19. Construction of a trivalent candidate Shigella vaccine strain with host-vector balanced-lethal system

    Institute of Scientific and Technical Information of China (English)

    芮贤良; 徐永强; 吴旭东; 苏国富; 黄翠芬

    1997-01-01

    A trivalent live Shigella vaccine candidate FSD01 against S. flexneri 2a, S. sonnei and S. dysen-teriae I was constructed. This candidate strain was based on the S. flexneri 2a vaccine T32. By homologous recombi-nation exchange, the chromosomal asd gene of T32 was site-specifically inactivated, resulting in the strain unable to grow normally in LB broth, while another asd gene of S. mutans was employed to construct an Asd complementary vector. This combination of asd ’host/ Asd+ vector formed a balanced-lethal expression system in T32 strain. By use of this system, two important protective antigen genes coding for S. sonnei Form I antigen and Shiga toxin B subunit were cloned and expressed in T32, which led to the construction of trivalent candidate vaccine FSD01. Experimental results showed that this strain was genetically stable, but its recombinant plasmid was non-resistant. Moreover, it was able to effectively express trivalent antigens in one host and induce protective responses in mice against the

  20. Global Classical Solutions for Partially Dissipative Hyperbolic System of Balance Laws

    Science.gov (United States)

    Xu, Jiang; Kawashima, Shuichi

    2014-02-01

    The basic existence theory of Kato and Majda enables us to obtain local-in-time classical solutions to generally quasilinear hyperbolic systems in the framework of Sobolev spaces (in x) with higher regularity. However, it remains a challenging open problem whether classical solutions still preserve well-posedness in the case of critical regularity. This paper is concerned with partially dissipative hyperbolic system of balance laws. Under the entropy dissipative assumption, we establish the local well-posedness and blow-up criterion of classical solutions in the framework of Besov spaces with critical regularity with the aid of the standard iteration argument and Friedrichs' regularization method. Then we explore the theory of function spaces and develop an elementary fact that indicates the relation between homogeneous and inhomogeneous Chemin-Lerner spaces (mixed space-time Besov spaces). This fact allows us to capture the dissipation rates generated from the partial dissipative source term and further obtain the global well-posedness and stability by assuming at all times the Shizuta-Kawashima algebraic condition. As a direct application, the corresponding well-posedness and stability of classical solutions to the compressible Euler equations with damping are also obtained.

  1. Deciding between compensated volume balance and real time transient models for pipeline leak detection system

    Energy Technology Data Exchange (ETDEWEB)

    Baptista, Renan Martins [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas. Div. de Explotacao]. E-mail: renan@cenpes.petrobras.com.br

    2000-07-01

    This paper describes a technical procedure to assess a software based leak detection system (LDS), by deciding between a simpler low cost, less effective product, having a fast installation and tuning, and a complex one with high cost and efficiency, which however takes a long time to be properly installed. This is a common decision among the pipeline operating companies, considering that the majority of the lines are short, with single phase liquid flow (which may include batches), basic communication system and instrumentation. Service companies offer realistic solutions for liquid flow, but usually designed to big pipeline networks, flowing multiple batches and allowing multiple fluid entrances and deliveries. Those solutions are sometimes impractical to short pipelines, due to its high cost, as well as long tuning procedures, complex instrumentation, communication and computer requirements. It is intended to approach here the best solution according to its cost. In a practical sense, it means to differentiate the various LDS techniques. Those techniques are available in a considerable number, and they are still spreading, according to the different scenarios. However, two most known and worldwide implemented techniques hold the majority of the market: the Compensated Volume Balance (CVB), which is less accurate, reliable and robust, but cheaper, simpler and faster to install, and the Real Time Transient Model (RTTM), which is very reliable, accurate and robust, but expensive and complex. This work will describe a way to define whether one can use or not a CVB in a pipeline. (author)

  2. A simple, mass balance model of carbon flow in a controlled ecological life support system

    Science.gov (United States)

    Garland, Jay L.

    1989-01-01

    Internal cycling of chemical elements is a fundamental aspect of a Controlled Ecological Life Support System (CELSS). Mathematical models are useful tools for evaluating fluxes and reservoirs of elements associated with potential CELSS configurations. A simple mass balance model of carbon flow in CELSS was developed based on data from the CELSS Breadboard project at Kennedy Space Center. All carbon reservoirs and fluxes were calculated based on steady state conditions and modelled using linear, donor-controlled transfer coefficients. The linear expression of photosynthetic flux was replaced with Michaelis-Menten kinetics based on dynamical analysis of the model which found that the latter produced more adequate model output. Sensitivity analysis of the model indicated that accurate determination of the maximum rate of gross primary production is critical to the development of an accurate model of carbon flow. Atmospheric carbon dioxide was particularly sensitive to changes in photosynthetic rate. The small reservoir of CO2 relative to large CO2 fluxes increases the potential for volatility in CO2 concentration. Feedback control mechanisms regulating CO2 concentration will probably be necessary in a CELSS to reduce this system instability.

  3. The human cutaneous chemokine system

    Directory of Open Access Journals (Sweden)

    Bernhard eMoser

    2011-08-01

    Full Text Available Irrespective of the immune status, the vast majority of all lymphocytes reside in peripheral tissues whereas those present in blood only amount to a small fraction of the total. It has been estimated that T cells in healthy human skin outnumber those present in blood by at least a factor of two. How lymphocytes within these two compartments relate to each other is not well understood. However, mounting evidence suggest that the study of T cell subsets present in peripheral blood does not reflect the function of their counterparts at peripheral sites. This is especially true under steady-state conditions whereby long-lived memory T cells in healthy tissues, notably those in epithelial tissues at body surfaces, are thought to fulfil a critical immune surveillance function by contributing to the first line of defence against a series of local threats, including microbes, tumours and toxins, and by participating in wound healing. The relative scarcity of information regarding peripheral T cells and the factors regulating their localization is primarily due to inherent difficulties in obtaining healthy tissue for the extraction and study of immune cells on a routine basis. This is most certainly true for humans. Here, we review our current understanding of T cell homing to human skin and discuss candidate chemokines that may account for the tissue selectivity in this process.

  4. The NATO Unmanned Aircraft System Human Systems Integration Guidebook

    Science.gov (United States)

    2012-11-01

    High level indicators of where human system interactions may occur • Textual descriptions of the overall human component of the system • Use cases...for specific team tasks  Type of interaction – i.e., collaborate, coordinate, supervise, etc.  Team cohesiveness indicators – i.e., trust

  5. Semiactive balancing control scheme in a rotor - bearing system supported on Mr. Dampers: design and experiments

    Energy Technology Data Exchange (ETDEWEB)

    Silva Navarro, Gerardo; Cabrera Amado, Alvaro [Cinvestav, IPN, Mexico, D.F. (Mexico)

    2007-11-15

    This paper deals with the problem of semiactive balancing control of a rotor-bearing system, where one journal bearings is supported on two radial Magneto-Rheological (MR) dampers. The mathematical model of the rotor-bearing system results from an orthotropic Jeffcott-like model and the dynamics associated to the MR dampers, whose rheological properties depend on the current inputs. For control purposes we use the Choi-Lee-Park polynomial for the MR dampers, which is quite consistent with the tpical nonlinear and complex hysteresis behavior and also simplifies the physical implementation on an experimental setup. The semiactive control scheme for the unbalance reponse of the rotor-bearing system is synthesized using sliding-mode control techniques. Some numerical and experimental results are included to illustrate the dynamic performance and robustness of the overall system. [Spanish] En este trabajo se abora el problema de control semiactivo del desbalance en un sistema rotor-chumacera, donde una de las chumaceras convencionales se monta sobre una suspension con dos amortiguadores Magneto-Reologicos (MR) radiales. El modelo matematico del sistema rotorchumacera se obtiene de un modelo tipo Jefcott ortotropico y la dinamica de los amortiguadores MR, cuyas propiedades reologicas dependen de las corrientes electricas de alimentacion. Para propositos de control se emplea el modelo polinomial de Choi-Lee-Park para los dos amortiguadores MR, el cual es consistente con el tipico comportamiento no-lineal y de histeresis, permitiendo simplificar su implementacion fisica en una plataforma experimental. El esquema de control semiactivo de la respuesta al desbalance, en el sistema rotor-chumacera, se basa en las tecnicas de control por modos deslizantes. Se presentan algunos resultados de simulacion numerica y experimentos que utilizan el funcionamiento y robustez del sistema completo.

  6. CRESST Human Performance Knowledge Mapping System

    Science.gov (United States)

    2002-12-01

    team processes and team outcomes. Computers in Human Behavior , 15, 463-494. 0 Herl, H. E. (1995). Construct validation of an approach to modeling...system to measure content understanding. Computers in Human Behavior , 15, 315-334. Johnson, R.F. (2001). Statistical measures of marksmanship (ARI...problem-solving. Computers in Human Behavior , 15, 403-418. West, C. D., Pomeroy, J. R., Park, J. K., Gerstenberger, E. A., & Sandoval, J. (2000

  7. Modeling human operator involvement in robotic systems

    NARCIS (Netherlands)

    Wewerinke, P.H.

    1991-01-01

    A modeling approach is presented to describe complex manned robotic systems. The robotic system is modeled as a (highly) nonlinear, possibly time-varying dynamic system including any time delays in terms of optimal estimation, control and decision theory. The role of the human operator(s) is modeled

  8. Cryosphere water balance in the HKH-system: case study Batura Glacier (Upper Hunza, Karakoram)

    Science.gov (United States)

    Winiger, M.; Boerst, U.

    2012-12-01

    Investigations on climate dynamics and related responses of the cryosphere in the Hindukush-Karakoram-Himalaya (HKH) increasingly result in regional different functional patterns. A predominant loss of ice and snow is documented for most of the region. Nevertheless, in the northwestern part, mainly in the Karakoram, several studies identified exemptions from the general HKH-pattern, either for individual glaciers or altitudinal ranges. Coordinated comparative studies, based on comparable methodological approaches and data bases might help to provide a better understanding of climate-cryosphere-runoff-systems. 'Third Pole Environment' (TEP), as well as the 'Upper Indus Basin' Initiative (UIB) of the 'International Centre for Integrated Mountain Development' (ICIMOD) promote and develop coordinated campaigns for the assessment of high altitude water balances in the HKH mountain ranges. As a first step, inventories of glaciers and snow-cover for HKH, the Tibetan Plateau, as well as its neighboring mountain ranges have been carried out. Glacier typology, climate related spatial and temporal dynamics, the impact of black carbon, dust and other influencing factors will further differentiate general inventories. In a next phase, case studies at selected sites, based on comparable approaches, thorough quality assessments of existing data series have been initiated by several research groups - up to now with only little coordination. Identification of case study sites should take advantage of previous studies. Although proper long-term monitoring is almost completely lacking, several glaciers in the Karakoram have repeatedly been investigated. Among them Raikot Glacier (Nanga Parbat), Biafo-Hispar glacier system, Baltoro Glacier (K2), and Batura Glacier (Gojal, Upper Hunza) are comparatively well documented examples. As part of the UIB-initiative, Batura, Passu and Baltoro Glaciers are in the process of repeat investigations of mass-balance. Selected first results of

  9. Human obesity as a heritable disorder of the central control of energy balance.

    Science.gov (United States)

    O'Rahilly, S; Farooqi, I S

    2008-12-01

    In the spirit of celebration associated with the 20th anniversary of the Pennington Biomedical Research Center, we have seized the opportunity of taking a highly personal and not at all comprehensive 'whistle-stop tour' of a large body of evidence that, we feel, supports the following conclusions: (1) that body fat stores are regulated by biological control processes in humans as they are in lower animals; (2) that there are major inherited influences on the efficiency whereby such control processes operate in humans; (3) that the precise nature of those genetic and biological influences and how they interact with environmental factors are beginning to be understood; (4) that most of the genes discovered thus far have their principal impact on hunger, satiety and food intake; (5) that while there is understandable resistance to the notion that genes can influence a human behavior such as the habitual ingestion of food, the implications of these discoveries are essentially benign. Indeed, we hope that they may eventually lead to improved treatment for patients and, in addition, help to inculcate a more enlightened attitude to the obese with a reduction in their experience of social and economic discrimination.

  10. Comparison of intraobserver single-task reliabilities of the Interactive Balance System (IBS) and Vertiguard in asymptomatic subjects.

    Science.gov (United States)

    Schwesig, René; Hollstein, Lisa; Plontke, Stefan K; Delank, Karl-Stefan; Fieseler, Georg; Rahne, Torsten

    2017-03-01

    The intraobserver reliabilities of the Interactive Balance System (IBS) and Vertiguard were compared in 30 asymptomatic volunteers. Relative reliability for all IBS single tasks and parameters in the IBS was excellent (intraclass correlation coefficient, ICC ≥0.75). The ICC values ranged from 0.78 to 0.89. The ICC values of the Vertiguard system ranged from 0 to 0.75. The cumulative measure of injury risk of the Vertiguard system was highly reliable.

  11. A Vibrotactile and Plantar Force Measurement-Based Biofeedback System: Paving the Way towards Wearable Balance-Improving Devices

    OpenAIRE

    Christina Zong-Hao Ma; Anson Hong-Ping Wan; Duo Wai-Chi Wong; Yong-Ping Zheng; Winson Chiu-Chun Lee

    2015-01-01

    Although biofeedback systems have been used to improve balance with success, they were confined to hospital training applications. Little attempt has been made to investigate the use of in-shoe plantar force measurement and wireless technology to turn hospital training biofeedback systems into wearable devices. This research developed a wearable biofeedback system which detects body sway by analyzing the plantar force and provides users with the corresponding haptic cues. The effects of this ...

  12. Open Marriage: Implications for Human Service Systems

    Science.gov (United States)

    O'Neill, Nena; O'Neill, George

    1973-01-01

    The authors of Open Marriage reiterate the meaning and possibilities of the open marriage concept and advance suggestions for change in the areas of residence, work, child care, and educational patterns. Human service systems must search out the universal values to be maintained in all human relationships. (Editor)

  13. Systems biology of human atherosclerosis.

    Science.gov (United States)

    Shalhoub, Joseph; Sikkel, Markus B; Davies, Kerry J; Vorkas, Panagiotis A; Want, Elizabeth J; Davies, Alun H

    2014-01-01

    Systems biology describes a holistic and integrative approach to understand physiology and pathology. The "omic" disciplines include genomics, transcriptomics, proteomics, and metabolic profiling (metabonomics and metabolomics). By adopting a stance, which is opposing (yet complimentary) to conventional research techniques, systems biology offers an overview by assessing the "net" biological effect imposed by a disease or nondisease state. There are a number of different organizational levels to be understood, from DNA to protein, metabolites, cells, organs and organisms, even beyond this to an organism's context. Systems biology relies on the existence of "nodes" and "edges." Nodes are the constituent part of the system being studied (eg, proteins in the proteome), while the edges are the way these constituents interact. In future, it will be increasingly important to collaborate, collating data from multiple studies to improve data sets, making them freely available and undertaking integrative analyses.

  14. Human-Systems Integration Processes (HSIP) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In FY12, this project removed the commercial-specific content from the Commercial Human-Systems Integration Design Processes (CHSIP), identified gaps in the...

  15. Human Systems Integration (HSI) in Acquisition

    Science.gov (United States)

    2009-08-01

    Cost/Risk Drivers The numbers in the Activities boxes correspond to the numbers In the Inputs and Outputs boxes. Tools: ● CATIA ● HSI Requirements...Technology Development Phase (Inputs) Human Systems Integration Tools: ● IMPRINT ● CATIA ● IPME References: ● DODI 5000.02 & DODD 5000.01 ● DAG ● CJCSI...Human Systems Integration Tools: ● IMPRINT ● CATIA ● IPME Activities for Each Output: 1.0 Incorporate domain considerations into baseline

  16. Balance Problems

    Science.gov (United States)

    ... you are having balance problems, see your doctor. Balance disorders can be signs of other health problems, such ... cases, treating the illness that is causing the disorder will help with the balance problem. Exercises, a change in diet, and some ...

  17. Mass Balance Modeling for Electric Arc Furnace and Ladle Furnace System in Steelmaking Facility in Turkey

    Institute of Scientific and Technical Information of China (English)

    (I)smail Ekmek(c)i; Ya(s)ar Yetisken; (U)nal (C)amdali

    2007-01-01

    In the electric arc furnace (EAF) steel production processes, scrap steel is principally used as a raw material instead of iron ore. In the steelmaking process with EAF, scrap is first melted in the furnace and then the desired chemical composition of the steel can be obtained in a special furnace such as ladle furnace (LF). This kind of furnace process is used for the secondary refining of alloy steel. LF furnace offers strong heating fluxes and enables precise temperature control, thereby allowing for the addition of desired amounts of various alloying elements. It also provides outstanding desulfurization at high-temperature treatment by reducing molten steel fluxes and removing deoxidation products. Elemental analysis with mass balance modeling is important to know the precise amount of required alloys for the LF input with respect to scrap composition. In present study, chemical reactions with mass conservation law in EAF and LF were modeled altogether as a whole system and chemical compositions of the final steel alloy output can be obtained precisely according to different scrap compositions, alloying elements ratios, and other input amounts. Besides, it was found that the mass efficiency for iron element in the system is 95.93%. These efficiencies are calculated for all input elements as 8.45% for C, 30.31% for Si, 46.36% for Mn, 30.64% for P, 41.96% for S, and 69.79% for Cr, etc. These efficiencies provide valuable ideas about the amount of the input materials that are vanished or combusted for 100 kg of each of the input materials in the EAF and LF system.

  18. Configuring balanced scorecards for measuring health system performance: evidence from 5 years' evaluation in Afghanistan.

    Directory of Open Access Journals (Sweden)

    Anbrasi Edward

    2011-07-01

    Full Text Available BACKGROUND: In 2004, Afghanistan pioneered a balanced scorecard (BSC performance system to manage the delivery of primary health care services. This study examines the trends of 29 key performance indicators over a 5-year period between 2004 and 2008. METHODS AND FINDINGS: Independent evaluations of performance in six domains were conducted annually through 5,500 patient observations and exit interviews and 1,500 provider interviews in >600 facilities selected by stratified random sampling in each province. Generalized estimating equation (GEE models were used to assess trends in BSC parameters. There was a progressive improvement in the national median scores scaled from 0-100 between 2004 and 2008 in all six domains: patient and community satisfaction of services (65.3-84.5, p<0.0001; provider satisfaction (65.4-79.2, p<0.01; capacity for service provision (47.4-76.4, p<0.0001; quality of services (40.5-67.4, p<0.0001; and overall vision for pro-poor and pro-female health services (52.0-52.6. The financial domain also showed improvement until 2007 (84.4-95.7, p<0.01, after which user fees were eliminated. By 2008, all provinces achieved the upper benchmark of national median set in 2004. CONCLUSIONS: The BSC has been successfully employed to assess and improve health service capacity and service delivery using performance benchmarking during the 5-year period. However, scorecard reconfigurations are needed to integrate effectiveness and efficiency measures and accommodate changes in health systems policy and strategy architecture to ensure its continued relevance and effectiveness as a comprehensive health system performance measure. The process of BSC design and implementation can serve as a valuable prototype for health policy planners managing performance in similar health care contexts. Please see later in the article for the Editors' Summary.

  19. Modeling and Performance Evaluation of Early Arrival Discrete Time Queueing System with Load Balancing Using Geometrical Distribution

    Directory of Open Access Journals (Sweden)

    Syed Asif AliShah

    2011-10-01

    Full Text Available Load balancing is an efficient technique used to maximize throughput, optimal resource utilization, minimized response time and avoiding congestion. This can be achieved by distributing the workload evenly across two or more network stations, nodes or buffers, links, central processing units, hard drives, or other resources. In this paper, we have modeled and developed a load balancing approach in a discrete-time domain to analyze and evaluate the system of finite network buffers using an early arrival system. Our approach of modeling such a system consists of two steps. The first step is the determination of all system-state stages and their corresponding transition probabilities. Next, we compute various performance measures by utilizing the system state transition probabilities for its steady-state behavior.

  20. Balancing control method by dispersed generators based on H{sub {infinity}} control theory in DC power feeding system

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Kenichi; Goya, Tomonori; Senjyu, Tomonobu; Yona, Atsushi; Urasaki, Naomitsu [University of the Ryukyus, 1 Senbaru Nishihara-cho Nakagami, Okinawa 903-0213 (Japan); Funabashi, Toshihisa [Meidensha Corporation, 36-2 Nihonbashi-Hakozakicho Chuo-ku, Tokyo 103-8513 (Japan); Kim, Chul-Hwan [Sungkyunkwan University and NPT Center, Suwon City 440-746 (Korea)

    2011-01-15

    Recently, dispersed generators have been installed in distribution network to supply power to commercial facilities. Renewable energy generation contains output power fluctuations and distributed generator produces sluggish response for power demand. In order to overcome these problems, an ultra capacitor energy storage system is used for compensating the instantaneous power imbalance. However, use of a large capacity ultra capacitor energy system increases system cost. In addition, PPSs (Power Producer and Supplier) that own these generators are supposed to achieve 30-min balancing control for stable supply of electric power. This paper proposes a control system to achieve both 30-min balancing control and interconnection point power flow control by using a fuel cell and an ultra capacitor based on the H{sub {infinity}} control theory. Besides, remaining storage energy of the ultra capacitor is controlled to be constant to maintain compensation capability. Effectiveness of the proposed control system is verified by using simulation results. (author)

  1. Raz on rights: human rights, fundamental rights and balancing\\ud

    OpenAIRE

    Zanghellini, Aleardo

    2017-01-01

    After clarifying the outlines of Raz’s interest theory of rights and its relationship to aspects of the principles theory of rights, I consider how his recent observations on human rights fit (or fail to fit) into the interest theory. I then address two questions. First, I elaborate on Raz’s definition of morally fundamental rights, arguing that he is right in claiming that there are no such rights. I then show that the interest theory accommodates the notion that rights may take qualitative ...

  2. Metagenomic Systems Biology of the Human Microbiome

    DEFF Research Database (Denmark)

    Bonde, Ida

    The human microbiome is an integrated part of the human body, outnumbering the human cells by approximately a factor 10. These microorganisms are very important for human health, hence knowledge about this, ”our other genome”, has been growing rapidly in recent years. This is manly due to the adv......The human microbiome is an integrated part of the human body, outnumbering the human cells by approximately a factor 10. These microorganisms are very important for human health, hence knowledge about this, ”our other genome”, has been growing rapidly in recent years. This is manly due...... in the system. Applying the CAG clustering method to data from the human gut microbiome, we identified dependency-associations between plasmids, phages and clone-specific gene sets to their bacterial host. Connections between CRISPR-elements and phages were also observed. Additionally, the persistence of some...... bacterial species in the human gut could be predicted based on absence or presence of specific genetic modules. Based on the same CAG clustering of the human gut microbiome data, the link between bile acid degradation of bacteria in the gut and obesity was investigated. There seemed to be a slight...

  3. Deiodinases: the balance of thyroid hormone: type 1 iodothyronine deiodinase in human physiology and disease.

    Science.gov (United States)

    Maia, Ana Luiza; Goemann, Iuri Martin; Meyer, Erika L Souza; Wajner, Simone Magagnin

    2011-06-01

    Thyroid hormone is essential for the normal function of virtually all tissues. The iodothyronine deiodinases catalyze the removal of an iodine residue from the pro-hormone thyroxine (T(4)) molecule, thus producing either the active form triiodothyronine (T(3); activation) or inactive metabolites (reverse T(3); inactivation). Type I deiodinase (D1) catalyzes both reactions. Over the last years, several studies have attempted to understand the mechanisms of D1 function, underlying its effects on normal thyroid hormone metabolism and pathological processes. Although peripheral D1-generated T(3) production contributes to a portion of plasma T(3) in euthyroid state, pathologically increased thyroidal D1 activity seems to be the main cause of the elevated T(3) concentrations observed in hyperthyroid patients. On the other hand, D1-deficient mouse models show that, in the absence of D1, inactive and lesser iodothyronines are excreted in feces with the loss of associated iodine, demonstrating the scavenging function for D1 that might be particularly important in an iodine deficiency setting. Polymorphisms in the DIO1 gene have been associated with changes in serum thyroid hormone levels, whereas decreased D1 activity has been reported in the nonthyroid illness syndrome and in several human neoplasias. The current review aims at presenting an updated picture of the recent advances made in the biochemical and molecular properties of D1 as well as its role in human physiology.

  4. Balanced Rotating Spray Tank and Pipe Cleaning and Cleanliness Verification System

    Science.gov (United States)

    Caimi, Raoul E. B. (Inventor); Thaxton, Eric A. (Inventor)

    1998-01-01

    A system for cleaning and verifying the cleanliness of the interior surfaces of hollow items, such as small bottles, tanks, pipes and tubes, employs a rotating spray head for supplying a gas-liquid cleaning mixture to the item's surface at a supersonic velocity. The spray head incorporates a plurality of nozzles having diverging cross sections so that the incoming gas-liquid mixture is first converged within the spray head and then diverged through the nozzles, thereby accelerating the mixture to a supersonic velocity. In the preferred embodiment, three nozzles are employed; one forwardly facing nozzle at the end of the spray head and two oppositely facing angled nozzles exiting on opposite sides of the spray head which balance each other, and therefore impart no net side load on the spray head. A drive mechanism is provided to rotate the spray head and at the same time move the head back and forth within the item to be cleaned. The drive mechanism acts on a long metal tube to which the spray head is fixed, and thus no moving parts are exposed to the interior surfaces of the items to be cleaned, thereby reducing the risk of contamination.

  5. Mathematical modelling of nutrient balance of a goldfish (Carassius auratus Linn. recirculating aquaculture system (GRAS

    Directory of Open Access Journals (Sweden)

    Sudeep Puthravilakom Sadasivan Nair

    2010-08-01

    Full Text Available In the present study, a goldfish (Carassius auratus Linn. recirculating aquaculture system (GRAS has been developed. The GRAS consisted of a culture tank, a screen filter and a foam fractionator for removal of particulate and dissolved solids and a trickling filter for conversion of ammonium- and nitrite-nitrogen to relatively harmless nitrate-nitrogen. The culture of goldfish at a stocking density of 1.08 kg/m3 was continued for a period of two and half months. Based on mass balance analysis of ammonium- and nitrate-nitrogen and assuming the trickling filter to be a plug flow reactor, a model was formulated to determine the necessary recirculation flow rate at different times of culture for maintaining the major nutrients, viz., ammonium- and nitrate-nitrogen below their permissible limits. The model was calibrated and validated using the real time data obtained from the experimental run. The high values of coefficient of determination and low values of root mean square error show the effectiveness of the model.

  6. Land-Based Wind Plant Balance-of-System Cost Drivers and Sensitivities (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Mone, C.; Maples, B.; Hand, M.

    2014-04-01

    With Balance of System (BOS) costs contributing up to 30% of the installed capital cost, it is fundamental to understand the BOS costs for wind projects as well as potential cost trends for larger turbines. NREL developed a BOS model using project cost estimates developed by industry partners. Aspects of BOS covered include engineering and permitting, foundations for various wind turbines, transportation, civil work, and electrical arrays. The data introduce new scaling relationships for each BOS component to estimate cost as a function of turbine parameters and size, project parameters and size, and geographic characteristics. Based on the new BOS model, an analysis to understand the non‐turbine wind plant costs associated with turbine sizes ranging from 1-6 MW and wind plant sizes ranging from 100-1000 MW has been conducted. This analysis establishes a more robust baseline cost estimate, identifies the largest cost components of wind project BOS, and explores the sensitivity of the capital investment cost and the levelized cost of energy to permutations in each BOS cost element. This presentation shows results from the model that illustrate the potential impact of turbine size and project size on the cost of energy from US wind plants.

  7. Advances in numerical methods for the solution of population balance equations for disperse phase systems

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Accurate prediction of the evolution of particle size distribution is critical to determining the dynamic flow structure of a disperse phase system.A population balance equation(PBE),a non-linear hyperbolic equation of the number density function,is usually employed to describe the micro-behavior(aggregation,breakage,growth,etc.) of a disperse phase and its effect on particle size distribution.Numerical solution is the only choice in most cases.In this paper,three different numerical methods(direct discretization methods,Monte Carlo methods,and moment methods) for the solution of a PBE are evaluated with regard to their ease of implementation,computational load and numerical accuracy.Special attention is paid to the relatively new and superior moment methods including quadrature method of moments(QMOM),direct quadrature method of moments(DQMOM),modified quadrature method of moments(M-QMOM),adaptive direct quadrature method of moments(ADQMOM),fixed pivot quadrature method of moments(FPQMOM),moving particle ensemble method(MPEM) and local fixed pivot quadrature method of moments(LFPQMOM).The prospects of these methods are discussed in the final section,based on their individual merits and current state of development of the field.

  8. Advances in numerical methods for the solution of population balance equations for disperse phase systems

    Institute of Scientific and Technical Information of China (English)

    SU JunWei; GU ZhaoLin; XU X.Yun

    2009-01-01

    Accurate prediction of the evolution of particle size distribution is critical to determining the dynamic flow structure of a disperse phase system.A population balance equation(PBE),a non-linear hyperbolic equation of the number density function,is usually employed to describe the micro-behavior(aggregation,breakage,growth,etc.)of a disperse phase and its effect on particle size distribution.Numerical solution is the only choice in most cases.In this paper,three different numerical methods(direct discretization methods,Monte Carlo methods,and moment methods)for the solution of a PBE are evaluated with regard to their ease of implementation,computational load and numerical accuracy.Special attention is paid to the relatively new and superior moment methods including quadrature method of moments(QMOM),direct quadrature method of moments(DQMOM),modified quadrature method of moments(M-QMOM),adaptive direct quadrature method of moments(ADOMOM),fixed pivot quadrature method of moments(FPQMOM),moving particle ensemble method(MPEM)and local fixed pivot quadrature method of moments(LFPQMOM).The prospects of these methods ere discussed in the final section,based on their individual merits and current state of development of the field.

  9. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.

    Science.gov (United States)

    Cota, Daniela; Marsicano, Giovanni; Tschöp, Matthias; Grübler, Yvonne; Flachskamm, Cornelia; Schubert, Mirjam; Auer, Dorothee; Yassouridis, Alexander; Thöne-Reineke, Christa; Ortmann, Sylvia; Tomassoni, Federica; Cervino, Cristina; Nisoli, Enzo; Linthorst, Astrid C E; Pasquali, Renato; Lutz, Beat; Stalla, Günter K; Pagotto, Uberto

    2003-08-01

    The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1-/-) exhibited reduced spontaneous caloric intake and, as a consequence of reduced total fat mass, decreased body weight. In young CB1-/- mice, the lean phenotype is predominantly caused by decreased caloric intake, whereas in adult CB1-/- mice, metabolic factors appear to contribute to the lean phenotype. No significant differences between genotypes were detected regarding locomotor activity, body temperature, or energy expenditure. Hypothalamic CB1 mRNA was found to be coexpressed with neuropeptides known to modulate food intake, such as corticotropin-releasing hormone (CRH), cocaine-amphetamine-regulated transcript (CART), melanin-concentrating hormone (MCH), and preproorexin, indicating a possible role for endocannabinoid receptors within central networks governing appetite. CB1-/- mice showed significantly increased CRH mRNA levels in the paraventricular nucleus and reduced CART mRNA levels in the dorsomedial and lateral hypothalamic areas. CB1 was also detected in epidydimal mouse adipocytes, and CB1-specific activation enhanced lipogenesis in primary adipocyte cultures. Our results indicate that the cannabinoid system is an essential endogenous regulator of energy homeostasis via central orexigenic as well as peripheral lipogenic mechanisms and might therefore represent a promising target to treat diseases characterized by impaired energy balance.

  10. On the diversity enhancement and power balancing of per-subcarrier antenna selection in OFDM systems

    KAUST Repository

    Park, Kihong

    2010-09-01

    In this paper, we consider multi-carrier systems with multiple transmit antennas under a power balancing constraint. Applying transmit antenna selection and discrete rate adaptive modulation using M-ary quadrature amplitude modulation (QAM) according to the channel variation per subcarrier, we develop an optimal antenna selection scheme in terms of maximum spectral efficiency where all the possible grouping to send the same information bearing signals in a group of subcarriers are searched and the groups of subcarriers to provide the frequency diversity gain are formed. In addition, we propose a suboptimal method to reduce the computational complexity of the optimal method. The suboptimal scheme consider only the subcarriers under outage and those are combined sequentially until it meets a required SNR. Numerical results show that the proposed suboptimal method with diversity combining outperforms the optimal antenna selection without diversity combining introduced in [1], especially for low SNR region and offers the spectral efficiency close to that of the optimal method with diversity combining, while maintaining lower complexity. ©2010 IEEE.

  11. Human Adaptive Mechatronics and Human-System Modelling

    Directory of Open Access Journals (Sweden)

    Satoshi Suzuki

    2013-03-01

    Full Text Available Several topics in projects for mechatronics studies, which are ʹHuman Adaptive Mechatronics (HAMʹ and ʹHuman‐System Modelling (HSMʹ, are presented in this paper. The main research theme of the HAM project is a design strategy for a new intelligent mechatronics system, which enhances operatorsʹ skills during machine operation. Skill analyses and control system design have been addressed. In the HSM project, human modelling based on hierarchical classification of skills was studied, including the following five types of skills: social, planning, cognitive, motion and sensory‐motor skills. This paper includes digests of these research topics and the outcomes concerning each type of skill. Relationships with other research activities, knowledge and information that will be helpful for readers who are trying to study assistive human‐mechatronics systems are also mentioned.

  12. Selenium removal and mass balance in a constructed flow-through wetland system.

    Science.gov (United States)

    Gao, S; Tanji, K K; Lin, Z Q; Terry, N; Peters, D W

    2003-01-01

    A field study on the removal of Se from agricultural subsurface drainage was conducted from May 1997 to February 2001 in the Tulare Lake Drainage District (TLDD) of San Joaquin Valley, California. A flow-through wetland system was constructed consisting of ten 15- x 76-m unlined cells that were continuously flooded and planted with either a monotype or combination of plants, including sturdy bulrush [Schoenoplectus robustus (Pursh) M.T. Strong], baltic rush (Juncus balticus Willd.), smooth cordgrass (Spartina alterniflora Loisel.), rabbitsfoot grass [Polypogon monspeliensis (L.) Desf.], salt-grass lDistichlis spicata (L.) Greene], cattail (Typha latifolia L.), tule [Schoenoplectus acutus (Muhl. ex Bigelow) A. Löve & D. Löve], and widgeon grass (Ruppia maritima L.). One cell had no vegetation planted. The objectives of this research were to evaluate Se removal efficiency of each wetland cell and to carry out a mass balance on Se. The inflow drainage water to the cells had average annual Se concentrations of 19 to 22 microg L(-1) dominated by selenate [Se(VI), 95%]. Average weekly water residence time varied from about 3 to 15 d for Cells 1 through 7 (target 7 d), 19 to 33 d for Cells 8 and 9 (target 21 d), and 13 to 18 d for Cell 10 (target 14 d). Average weekly Se concentration ratios of outflow to inflow ranged from 0.45 to 0.79 and mass ratio (concentration x water volume) from 0.24 to 0.52 for year 2000, that is, 21 to 55% reduction in Se concentration and 48 to 76% Se removal in mass by the wetland, respectively. The nonvegetated cell showed the least Se removal both in concentration and in mass. The global mass balance showed that on the average about 59% of the total inflow Se was retained within the cells and Se outputs were outflow (35%), seepage (4%), and volatilization (2%). Independent measurements of the Se retained in the cells totaled 53% of the total Se inflow: 33% in the surface (0-20 cm) sediment, 18% in the organic detrital layer above the

  13. Human capital in the German urban system – Patterns of concentration and specialisation

    Directory of Open Access Journals (Sweden)

    Anna Growe

    2010-08-01

    Full Text Available In the knowledge economy human capital plays a crucial role in various economic processes and thus also in spatial development. But human capital is an economic resource that is distributed unequally in space. Some regions show a higher density of human capital than others. This paper discusses questions relating to the spatial concentration and specialisation of human capital in the German urban system. Due to an increasing interest in human capital the questions are asked, where is human capital located in the German urban system and how does the distribution change over time. The paper relates to geographical theories of concentration and specialisation. It will be shown that human capital is a heterogeneous category containing different occupational groups showing different spatial patterns. Some display increasing spatial disparities; others are fairly balanced over space.

  14. A case for human systems neuroscience.

    Science.gov (United States)

    Gardner, J L

    2015-06-18

    Can the human brain itself serve as a model for a systems neuroscience approach to understanding the human brain? After all, how the brain is able to create the richness and complexity of human behavior is still largely mysterious. What better choice to study that complexity than to study it in humans? However, measurements of brain activity typically need to be made non-invasively which puts severe constraints on what can be learned about the internal workings of the brain. Our approach has been to use a combination of psychophysics in which we can use human behavioral flexibility to make quantitative measurements of behavior and link those through computational models to measurements of cortical activity through magnetic resonance imaging. In particular, we have tested various computational hypotheses about what neural mechanisms could account for behavioral enhancement with spatial attention (Pestilli et al., 2011). Resting both on quantitative measurements and considerations of what is known through animal models, we concluded that weighting of sensory signals by the magnitude of their response is a neural mechanism for efficient selection of sensory signals and consequent improvements in behavioral performance with attention. While animal models have many technical advantages over studying the brain in humans, we believe that human systems neuroscience should endeavor to validate, replicate and extend basic knowledge learned from animal model systems and thus form a bridge to understanding how the brain creates the complex and rich cognitive capacities of humans.

  15. DESIGN METHODS OF HUMAN DEVELOPMENT MANAGEMENT SYSTEM

    Directory of Open Access Journals (Sweden)

    Stanislav E. Elkin

    2017-09-01

    Full Text Available The article discusses the concept of "human development" and the schematic diagram of the organizational design of regional management systems in relation to human development. Management as an organizational process in the study is considered as part of all social subsystems, specifies regularities of development and formation of new structures and functions. In the study applied the following methods: allocation of levels of models, techniques of domination, the allocation phases of the operation, the construction of generalized indicators, etc. As a result of research design problems of systems management human development revealed that the primary means of successful adaptation of organizations to changing conditions is an effective mechanism for management of human capacity, which will provide the best in current economic terms the end results that allows you to apply the concept of "innovation potential" in relation to the process of human development.

  16. Physical stability of coconut oil lotions formulated using hydrophile-lipophile balance system of various emulsifier pairs.

    Science.gov (United States)

    Boonme, Prapaporn; Maneenuan, Duangkhae; Channarong, Sunee

    2013-01-01

    The aim of this study was to prepare coconut oil lotions using a hydrophile-lipophile balance system to calculate the proportion of each nonionic surfactant used. The effects of emulsifier pairs in the formulations on physical properties (i.e., appearance, emulsion type, pH, flow type, viscosity) were investigated. The physical stability of the lotions was determined at ambient temperature (approximatley 30 degrees C) after the lotions were kept for 30 as well as 60 days and in accelerated conditions (6 freeze-thaw cycles). It was found that the formulations most tolerant to such harsh conditions were F1 and F2, o/w lotions containing 40% w/w coconut oil, 50% w/w water and 10% w/w of the mixed emulsifier of a low hydrophile-lipophile balance surfactant (sorbitan monostearate) and a high hydrophile-lipophile balance surfactant (either polyoxyethylene [20] sorbitan monooleate or polyethylene [20] sorbitan monolaurate).

  17. New Modulation Strategy to Balance the Neutral-Point Voltage for Three-Level Neutral-Clamped Inverter Systems

    DEFF Research Database (Denmark)

    Choi, Uimin; Lee, June-Seok; Lee, Kyo-Beum

    2014-01-01

    This paper proposes a new modulation strategy that balances the neutral-point voltage for three-level neutral-clamped inverter systems. The proposed modulation replaces the P-type or N-type small switching states with other switching states that do not affect the neutral-point voltage. The zero...... and medium switching states are employed to help the neutral-point voltage balancing. This method little bit increases the switching events and output total harmonic distortion. However, this method has a strong balancing ability at all regions. Further, it is very simple to implement in both space vector...... modulation and carrier-based PWM methods. Simulation and experimental results verify the validity and feasibility of the proposed new modulation strategy....

  18. Protective balance and startle responses to sudden freefall in standing humans.

    Science.gov (United States)

    Sanders, Ozell P; Savin, Douglas N; Creath, Robert A; Rogers, Mark W

    2015-01-23

    The aim of the present study was to investigate whether or not startle reactions contribute to the whole body postural responses following sudden freefall in standing humans. Nine healthy participants stood atop a moveable platform and received externally-triggered (EXT) and selftriggered (SLF) drop perturbations of the support surface. Electromyographic (EMG) activity was recorded bilaterally over the sternocleidomastoid (SCM), deltoid (DLT), biceps brachii (BIC), medial gastrocnemius (GAS), and tibialis anterior (TA) muscles. Whole-body kinematics were also recorded with motion analysis. Rapid phasic activation of SCM during the first trial response (FTR) was seen for all participants for EXT and for 56% of subjects for SLF. Reductions in EMG amplitude between the EXT FTR and later trial responses for SCM, DLT, and BIC and reduced arm movement acceleration indicative of habituation occurred and exceeded adaptive reductions for SLF. These findings suggested that a startle reflex contributes to the exaggerated postural FTR observed during externally-triggered whole-body free falls.

  19. Psychotherapy is an ethical endeavor: Balancing science and humanism in clinical practice.

    Science.gov (United States)

    Allen, Jon G

    2013-01-01

    The author proposes that psychotherapy is best grounded in scienceinformed humanism and, more specifically, that psychotherapists at least implicitly promote ethical, moral--and indeed, virtuous--behavior. In doing so, therapists are challenged continually to engage in making evaluative moral judgments without being judgmental. He contends that psychotherapists, and psychologists especially, are overly reliant on science and might benefit from being more explicit in their ethical endeavors by being better informed about the illuminating philosophical literature on ethics. He highlights the concept of mentalizing, that is, attentiveness to mental states in self and others, such as needs, feelings, and thoughts. He proposes that mentalizing in the context of attachment relationships is common to all psychotherapies, and that this common process is best understood conjointly from the perspectives of developmental psychology and ethics. The author defends the thesis that employing psychotherapy to promote ethical, moral, and virtuous functioning can be justified on scientific grounds insofar as this functioning is conducive to health.

  20. Functional Magnetic Resonance Imaging and the Challenge of Balancing Human Security with State Security

    CERN Document Server

    Sahito, Farhan

    2012-01-01

    Recent reports reveal that violent extremists are trying to obtain insider positions that may increase the impact of any attack on critical infrastructure and could potentially endanger state services, people's lives and even democracy. It is of utmost importance to be able to adopt extreme security measures in certain high-risk situations in order to secure critical infrastructure and thus lower the level of terrorist threats while preserving the rights of citizens. To counter these threats, our research is aiming for extreme measures to analyse and evaluate human threats related assessment methods for employee screening and evaluations using cognitive analysis technology, in particular functional Magnetic Resonance Imaging (fMRI). The development of fMRI has led some researchers to conclude that this technology has forensic potential and may be useful in investing personality traits, mental illness, psychopathology, racial prejudice and religious extremism. However, critics claim that this technology may pr...

  1. Balancing the principles: why the universality of human rights is not the Trojan horse of moral imperialism.

    Science.gov (United States)

    Semplici, Stefano

    2013-11-01

    The new dilemmas and responsibilities which arise in bioethics both because of the unprecedented pace of scientific development and of growing moral pluralism are more and more difficult to grapple with. At the 'global' level, the call for the universal nature at least of some fundamental moral values and principles is often being contended as a testament of arrogance, if not directly as a new kind of subtler imperialism. The human rights framework itself, which provided the basis for the most relevant international declarations and documents, is not exempt from the charge. However, the refusal of a top-down conception of the universal as a sort of product for exportation should not be confused with a relativistic landscape, where all the cows can be indifferently black or white. This contribution aims at outlining an approach, which reconciles universalism as enshrined in founding human rights declarations with respect for cultural diversity. In order to do so, two conceptual frameworks are discussed: the 'tool-kit' model and the morals/ethics difference. The example of the right to quality health care confirms the argument that striking a balance between cherishing pluralism and defending some fundamental rights and obligations does not amount to an assertion of moral imperialism.

  2. The Importance of the Ionic Product for Water to Understand the Physiology of the Acid-Base Balance in Humans

    Directory of Open Access Journals (Sweden)

    María M. Adeva-Andany

    2014-01-01

    Full Text Available Human plasma is an aqueous solution that has to abide by chemical rules such as the principle of electrical neutrality and the constancy of the ionic product for water. These rules define the acid-base balance in the human body. According to the electroneutrality principle, plasma has to be electrically neutral and the sum of its cations equals the sum of its anions. In addition, the ionic product for water has to be constant. Therefore, the plasma concentration of hydrogen ions depends on the plasma ionic composition. Variations in the concentration of plasma ions that alter the relative proportion of anions and cations predictably lead to a change in the plasma concentration of hydrogen ions by driving adaptive adjustments in water ionization that allow plasma electroneutrality while maintaining constant the ionic product for water. The accumulation of plasma anions out of proportion of cations induces an electrical imbalance compensated by a fall of hydroxide ions that brings about a rise in hydrogen ions (acidosis. By contrast, the deficiency of chloride relative to sodium generates plasma alkalosis by increasing hydroxide ions. The adjustment of plasma bicarbonate concentration to these changes is an important compensatory mechanism that protects plasma pH from severe deviations.

  3. The importance of the ionic product for water to understand the physiology of the acid-base balance in humans.

    Science.gov (United States)

    Adeva-Andany, María M; Carneiro-Freire, Natalia; Donapetry-García, Cristóbal; Rañal-Muíño, Eva; López-Pereiro, Yosua

    2014-01-01

    Human plasma is an aqueous solution that has to abide by chemical rules such as the principle of electrical neutrality and the constancy of the ionic product for water. These rules define the acid-base balance in the human body. According to the electroneutrality principle, plasma has to be electrically neutral and the sum of its cations equals the sum of its anions. In addition, the ionic product for water has to be constant. Therefore, the plasma concentration of hydrogen ions depends on the plasma ionic composition. Variations in the concentration of plasma ions that alter the relative proportion of anions and cations predictably lead to a change in the plasma concentration of hydrogen ions by driving adaptive adjustments in water ionization that allow plasma electroneutrality while maintaining constant the ionic product for water. The accumulation of plasma anions out of proportion of cations induces an electrical imbalance compensated by a fall of hydroxide ions that brings about a rise in hydrogen ions (acidosis). By contrast, the deficiency of chloride relative to sodium generates plasma alkalosis by increasing hydroxide ions. The adjustment of plasma bicarbonate concentration to these changes is an important compensatory mechanism that protects plasma pH from severe deviations.

  4. Variable-length balanced codes for quadrature phase shift keyed systems

    Directory of Open Access Journals (Sweden)

    Xin Tu

    2015-10-01

    Full Text Available The authors outline an approach to construct capacity-approaching balanced quadrature phase shift keyed (QPSK codes. These codes ensure an equal number of different symbol values and many symbol transitions in the encoded sequence in order to assist practical demodulators to accurately recover symbol values. Their codes are comprised of instantaneously decodable variable-length codewords that exhibit excellent performance with average code rates higher than previously reported fixed-length balanced QPSK codes.

  5. Periprandial changes of the sympathetic-parasympathetic balance related to perceived satiety in humans

    NARCIS (Netherlands)

    Harthoorn, L.F.; Dransfield, E.

    2008-01-01

    Food intake regulation involves various central and peripheral mechanisms. In this study the relevance of physiological responses reflecting the autonomic nervous system were evaluated in relation to perceived satiety. Subjects were exposed to a lunch-induced hunger-satiety shift, while profiling di

  6. Periprandial changes of the sympathetic-parasympathetic balance related to perceived satiety in humans

    NARCIS (Netherlands)

    Harthoorn, L.F.; Dransfield, E.

    2008-01-01

    Food intake regulation involves various central and peripheral mechanisms. In this study the relevance of physiological responses reflecting the autonomic nervous system were evaluated in relation to perceived satiety. Subjects were exposed to a lunch-induced hunger-satiety shift, while profiling

  7. Effects of a Passive Online Software Application on Heart Rate Variability and Autonomic Nervous System Balance.

    Science.gov (United States)

    Rubik, Beverly

    2017-01-01

    This study investigated whether short-term exposure to a passive online software application of purported subtle energy technology would affect heart rate variability (HRV) and associated autonomic nervous system measures. This was a randomized, double-blinded, sham-controlled clinical trial (RCT). The study took place in a nonprofit laboratory in Emeryville, California. Twenty healthy, nonsmoking subjects (16 females), aged 40-75 years, participated. Quantum Code Technology(™) (QCT), a purported subtle energy technology, was delivered through a passive software application (Heart+ App) on a smartphone placed heart rate, total power, standard deviation node-to-node, root mean square sequential difference, low frequency to high frequency ratio (LF/HF), low frequency (LF), and high frequency (HF). Paired samples t-tests showed that for the Heart+ App, mean LF/HF decreased (p = 9.5 × 10(-4)), while mean LF decreased in a trend (p = 0.06), indicating reduced sympathetic dominance. Root mean square sequential difference increased for the Heart+ App, showing a possible trend (p = 0.09). Post-pre differences in LF/HF for sham compared with the Heart+ App were also significant (p Heart+ App that was working in the background on an active smartphone untouched by the subjects. This may be the first RCT to show that specific frequencies of a purported non-Hertzian type of subtle energy conveyed by software applications broadcast from personal electronic devices can be bioactive and beneficially impact autonomic nervous system balance.

  8. Aging of the Human Vestibular System

    Science.gov (United States)

    Zalewski, Christopher K.

    2015-01-01

    Aging affects every sensory system in the body, including the vestibular system. Although its impact is often difficult to quantify, the deleterious impact of aging on the vestibular system is serious both medically and economically. The deterioration of the vestibular sensory end organs has been known since the 1970s; however, the measurable impact from these anatomical changes remains elusive. Tests of vestibular function either fall short in their ability to quantify such anatomical deterioration, or they are insensitive to the associated physiologic decline and/or central compensatory mechanisms that accompany the vestibular aging process. When compared with healthy younger individuals, a paucity of subtle differences in test results has been reported in the healthy older population, and those differences are often observed only in response to nontraditional and/or more robust stimuli. In addition, the reported differences are often clinically insignificant insomuch that the recorded physiologic responses from the elderly often fall within the wide normative response ranges identified for normal healthy adults. The damaging economic impact of such vestibular sensory decline manifests itself in an exponential increase in geriatric dizziness and a subsequent higher prevalence of injurious falls. An estimated $10 to $20 billion dollar annual cost has been reported to be associated with falls-related injuries and is the sixth leading cause of death in the elderly population, with a 20% mortality rate. With an estimated 115% increase in the geriatric population over 65 years of age by the year 2050, the number of balanced-disordered patients with a declining vestibular system is certain to reach near epidemic proportions. An understanding of the effects of age on the vestibular system is imperative if clinicians are to better manage elderly patients with balance disorders, dizziness, and vestibular disease. PMID:27516717

  9. Description and development of the means of a model experiment for load balancing in distributed computing systems

    Science.gov (United States)

    Nagiyev, A. E.; Sherstnyova, A. I.; Botygin, I. A.; Galanova, N. Y.

    2016-06-01

    The results of the statistical model experiments research of various load balancing algorithms in distributed computing systems are presented. Software tools were developed. These tools, which allow to create a virtual infrastructure of distributed computing system in accordance with the intended objective of the research focused on multi-agent and multithreaded data processing were developed. A diagram of the control processing of requests from the terminal devices, providing an effective dynamic horizontal scaling of computing power at peak loads, is proposed.

  10. A Mass Balance Model for Designing Green Roof Systems that Incorporate a Cistern for Re-Use

    OpenAIRE

    Manoj Chopra; Martin Wanielista; Mike Hardin

    2012-01-01

    Green roofs, which have been used for several decades in many parts of the world, offer a unique and sustainable approach to stormwater management. Within this paper, evidence is presented on water retention for an irrigated green roof system. The presented green roof design results in a water retention volume on site. A first principle mass balance computer model is introduced to assist with the design of these green roof systems which incorporate a cistern to capture and reuse runoff waters...

  11. A novel disulphide switch mechanism in Ero1 balances ER oxidation in human cells

    DEFF Research Database (Denmark)

    Appenzeller-Herzog, Christian; Riemer, Jan; Christensen, Brian

    2008-01-01

    a feedback loop where activation of Ero1 is linked to the availability of its substrate, reduced protein disulphide isomerase (PDI). Overexpression of Ero1 -Cys131Ala or the isoform Ero1 , which does not have an equivalent disulphide switch, leads to augmented ER oxidation. These data reveal a novel...... regulatory feedback system where PDI emerges as a central regulator of ER redox homoeostasis....

  12. The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology.

    Science.gov (United States)

    Guerriero, Christopher J; Brodsky, Jeffrey L

    2012-04-01

    Protein folding is a complex, error-prone process that often results in an irreparable protein by-product. These by-products can be recognized by cellular quality control machineries and targeted for proteasome-dependent degradation. The folding of proteins in the secretory pathway adds another layer to the protein folding "problem," as the endoplasmic reticulum maintains a unique chemical environment within the cell. In fact, a growing number of diseases are attributed to defects in secretory protein folding, and many of these by-products are targeted for a process known as endoplasmic reticulum-associated degradation (ERAD). Since its discovery, research on the mechanisms underlying the ERAD pathway has provided new insights into how ERAD contributes to human health during both normal and diseases states. Links between ERAD and disease are evidenced from the loss of protein function as a result of degradation, chronic cellular stress when ERAD fails to keep up with misfolded protein production, and the ability of some pathogens to coopt the ERAD pathway. The growing number of ERAD substrates has also illuminated the differences in the machineries used to recognize and degrade a vast array of potential clients for this pathway. Despite all that is known about ERAD, many questions remain, and new paradigms will likely emerge. Clearly, the key to successful disease treatment lies within defining the molecular details of the ERAD pathway and in understanding how this conserved pathway selects and degrades an innumerable cast of substrates.

  13. Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart.

    Science.gov (United States)

    Anderson, Ethan J; Kypson, Alan P; Rodriguez, Evelio; Anderson, Curtis A; Lehr, Eric J; Neufer, P Darrell

    2009-11-10

    The aim of this study was to determine the impact of diabetes on oxidant balance and mitochondrial metabolism of carbohydrate- and lipid-based substrates in myocardium of type 2 diabetic patients. Heart failure represents a major cause of death among diabetic patients. It has been proposed that derangements in cardiac metabolism and oxidative stress may underlie the progression of this comorbidity, but scarce evidence exists in support of this mechanism in humans. Mitochondrial oxygen (O(2)) consumption and hydrogen peroxide (H(2)O(2)) emission were measured in permeabilized myofibers prepared from samples of the right atrial appendage obtained from nondiabetic (n = 13) and diabetic (n = 11) patients undergoing nonemergent coronary artery bypass graft surgery. Mitochondria in atrial tissue of type 2 diabetic individuals show a sharply decreased capacity for glutamate and fatty acid-supported respiration, in addition to an increased content of myocardial triglycerides, as compared to nondiabetic patients. Furthermore, diabetic patients show an increased mitochondrial H(2)O(2) emission during oxidation of carbohydrate- and lipid-based substrates, depleted glutathione, and evidence of persistent oxidative stress in their atrial tissue. These findings are the first to directly investigate the effects of type 2 diabetes on a panoply of mitochondrial functions in the human myocardium using cellular and molecular approaches, and they show that mitochondria in diabetic human hearts have specific impairments in maximal capacity to oxidize fatty acids and glutamate, yet increased mitochondrial H(2)O(2) emission, providing insight into the role of mitochondrial dysfunction and oxidative stress in the pathogenesis of heart failure in diabetic patients. 2009 by the American College of Cardiology Foundation

  14. Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in Atrium of Type 2 Diabetic Human Heart

    Science.gov (United States)

    Anderson, Ethan J.; Kypson, Alan P.; Rodriguez, Evelio; Anderson, Curtis A.; Lehr, Eric J.; Neufer, P. Darrell

    2009-01-01

    Objective This aim of this study was to determine the impact of diabetes on oxidant balance and mitochondrial metabolism of carbohydrate- and lipid-based substrates in myocardium of type 2 diabetic patients. Background Heart failure represents a major cause of death among diabetics, and it has been proposed that derangements in cardiac metabolism and oxidative stress may underlie the progression of this co-morbidity, but scarce evidence exists in support of this mechanism in humans. Methods Mitochondrial O2 consumption and H2O2 emission were measured in permeabilized myofibers prepared from samples of right atrial appendage obtained from non-diabetic (n=13) and diabetic (n=11) patients undergoing non-emergent coronary artery bypass graft surgery. Results Mitochondria in atrial tissue of type 2 diabetic individuals display a sharply decreased capacity for glutamate and fatty acid-supported respiration, in addition to an increased content of myocardial triglycerides, as compared to non-diabetics. Furthermore, diabetics display an increased mitochondrial H2O2 emission during oxidation of carbohydrate- and lipid-based substrates, depleted glutathione, and evidence of persistent oxidative stress in their atrial tissue. Conclusions These findings are the first to directly investigate the effects of type 2 diabetes on a panoply of mitochondrial functions in the human myocardium using cellular and molecular approaches, and they demonstrate that mitochondria in diabetic human heart have specific impairments in maximal capacity to oxidize fatty acids and glutamate, yet increased mitochondrial H2O2 emission, providing insight into the role of mitochondrial dysfunction and oxidative stress in the pathogenesis of heart failure in diabetic patients. PMID:19892241

  15. The family myth: its deconstruction and replacement with a balanced humanized narrative.

    Science.gov (United States)

    Kradin, Richard

    2009-04-01

    According to Carl Jung the mythopoeic activities of the collective unconscious contribute to the trajectory of personal individuation (Segal 1998). The 'family myth' represents an imaginal narrative that emphasizes the importance of the family's founders, its collective values, and its position with respect to 'outsiders'. Sigmund Freud identified the importance of the Oedipal myth as the basis of nuclear family dynamics (Rudnytsky 1992); however, the 'myth of the family' represents in reality a 'family of myths', each emphasizing different elements of potential interpersonal dynamics. But whereas some myths foster the child's optimal separation from parental influence and promote the process of individuation, others tend to hinder development. One potentially deleterious form of the family myth tends to serve the narcissistic wishes of parents in their bid to maintain influence over the child by fostering the archetypal features of their role. The children who are the targets of the myth are thwarted in their psychological development by virtue of the fact that they are denied the opportunity to humanize their archetypal projections onto their parent(s). The result is a persistence of childlike attitude with respect to people and situations that they encounter outside the nuclear family. The persistent constellation of the child archetype is evidenced by features of the puer aeternus, with deficits in the ability to work, form stable adult relationships, and create a separate nuclear family. The significance of this type of family myth in the inappropriate preservation of puerile attitudes is examined and the desire of the offending parent(s) to promote their own immortality is explored. The contribution of the myth to the transference and transference resistance is explicated and suggestions are offered with respect to how to approach this critical issue in analysis.

  16. Cytokine balance in human malaria: does Plasmodium vivax elicit more inflammatory responses than Plasmodium falciparum?

    Directory of Open Access Journals (Sweden)

    Raquel M Gonçalves

    Full Text Available BACKGROUND: The mechanisms by which humans regulate pro- and anti-inflammatory responses on exposure to different malaria parasites remains unclear. Although Plasmodium vivax usually causes a relatively benign disease, this parasite has been suggested to elicit more host inflammation per parasitized red blood cell than P. falciparum. METHODOLOGY/PRINCIPAL FINDINGS: We measured plasma concentrations of seven cytokines and two soluble tumor necrosis factor (TNF-α receptors, and evaluated clinical and laboratory outcomes, in Brazilians with acute uncomplicated infections with P. vivax (n = 85, P. falciparum (n = 30, or both species (n = 12, and in 45 asymptomatic carriers of low-density P. vivax infection. Symptomatic vivax malaria patients, compared to those infected with P. falciparum or both species, had more intense paroxysms, but they had no clear association with a pro-inflammatory imbalance. To the contrary, these patients had higher levels of the regulatory cytokine interleukin (IL-10, which correlated positively with parasite density, and elevated IL-10/TNF-α, IL-10/interferon (IFN-γ, IL-10/IL-6 and sTNFRII/TNF-α ratios, compared to falciparum or mixed-species malaria patient groups. Vivax malaria patients had the highest levels of circulating soluble TNF-α receptor sTNFRII. Levels of regulatory cytokines returned to normal values 28 days after P. vivax clearance following chemotherapy. Finally, asymptomatic carriers of low P. vivax parasitemias had substantially lower levels of both inflammatory and regulatory cytokines than did patients with clinical malaria due to either species. CONCLUSIONS: Controlling fast-multiplying P. falciparum blood stages requires a strong inflammatory response to prevent fulminant infections, while reducing inflammation-related tissue damage with early regulatory cytokine responses may be a more cost-effective strategy in infections with the less virulent P. vivax parasite. The early induction

  17. Human Systems Integration (HSI) Practitioner's Guide

    Science.gov (United States)

    Zumbado, Jennifer Rochlis

    2015-01-01

    The NASA/SP-2015-3709, Human Systems Integration (HSI) Practitioner's Guide, also known as the "HSIPG," provides a tool for implementing HSI activities within the NASA systems engineering framework. The HSIPG is written to aid the HSI practitioner engaged in a program or project (P/P), and serves as a knowledge base to allow the practitioner to step into an HSI lead or team member role for NASA missions. Additionally, this HSIPG is written to address the role of HSI in the P/P management and systems engineering communities and aid their understanding of the value added by incorporating good HSI practices into their programs and projects. Through helping to build a community of knowledgeable HSI practitioners, this document also hopes to build advocacy across the Agency for establishing strong, consistent HSI policies and practices. Human Systems Integration (HSI) has been successfully adopted (and adapted) by several federal agencies-most notably the U.S. Department of Defense (DoD) and the Nuclear Regulatory Commission (NRC)-as a methodology for reducing system life cycle costs (LCCs). These cost savings manifest themselves due to reductions in required numbers of personnel, the practice of human-centered design, decreased reliance on specialized skills for operations, shortened training time, efficient logistics and maintenance, and fewer safety-related risks and mishaps due to unintended human/system interactions. The HSI process for NASA establishes how cost savings and mission success can be realized through systems engineering. Every program or project has unique attributes. This HSIPG is not intended to provide one-size-fits-all recommendations for HSI implementation. Rather, HSI processes should be tailored to the size, scope, and goals of individual situations. The instructions and processes identified here are best used as a starting point for implementing human-centered system concepts and designs across programs and projects of varying types, including

  18. Parametrisation of the variety of human behaviour related to building energy consumption in the Town Energy Balance (SURFEX-TEB v. 8.2)

    Science.gov (United States)

    Schoetter, Robert; Masson, Valéry; Bourgeois, Alexis; Pellegrino, Margot; Lévy, Jean-Pierre

    2017-07-01

    The anthropogenic heat flux can be an important part of the urban surface energy balance. Some of it is due to energy consumption inside buildings, which depends on building use and human behaviour, both of which are very heterogeneous in most urban areas. Urban canopy parametrisations (UCP), such as the Town Energy Balance (TEB), parametrise the effect of the buildings on the urban surface energy balance. They contain a simple building energy model. However, the variety of building use and human behaviour at grid point scale has not yet been represented in state of the art UCPs. In this study, we describe how we enhance the Town Energy Balance in order to take fractional building use and human behaviour into account. We describe how we parametrise different behaviours and initialise the model for applications in France. We evaluate the spatio-temporal variability of the simulated building energy consumption for the city of Toulouse. We show that a more detailed description of building use and human behaviour enhances the simulation results. The model developments lay the groundwork for simulations of coupled urban climate and building energy consumption which are relevant for both the urban climate and the climate change mitigation and adaptation communities.

  19. Development of Human System Integration at NASA

    Science.gov (United States)

    Whitmore, Mihriban; McGuire, Kerry; Thompson, Shelby; Vos, Gordon

    2012-01-01

    Human Systems Integration seeks to design systems around the capabilities and limitations of the humans which use and interact with the system, ensuring greater efficiency of use, reduced error rates, and less rework in the design, manufacturing and operational deployment of hardware and software. One of the primary goals of HSI is to get the human factors practitioner involved early in the design process. In doing so, the aim is to reduce future budget costs and resources in redesign and training. By the preliminary design phase of a project nearly 80% of the total cost of the project is locked in. Potential design changes recommended by evaluations past this point will have little effect due to lack of funding or a huge cost in terms of resources to make changes. Three key concepts define an effective HSI program. First, systems are comprised of hardware, software, and the human, all of which operate within an environment. Too often, engineers and developers fail to consider the human capacity or requirements as part of the system. This leads to poor task allocation within the system. To promote ideal task allocation, it is critical that the human element be considered early in system development. Poor design, or designs that do not adequately consider the human component, could negatively affect physical or mental performance, as well as, social behavior. Second, successful HSI depends upon integration and collaboration of all the domains that represent acquisition efforts. Too often, these domains exist as independent disciplines due to the location of expertise within the service structure. Proper implementation of HSI through participation would help to integrate these domains and disciplines to leverage and apply their interdependencies to attain an optimal design. Via this process domain interests can be integrated to perform effective HSI through trade-offs and collaboration. This provides a common basis upon which to make knowledgeable decisions. Finally

  20. Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

    Directory of Open Access Journals (Sweden)

    Maya Ben-Yehuda Greenwald

    2016-01-01

    Full Text Available The skin, being the largest organ of the body, functions as a barrier between our body and the environment. It is consistently exposed to various exogenous and endogenous stressors (e.g., air pollutants, ionizing and non-ionizing irradiation, toxins, mitochondrial metabolism, enzyme activity, inflammatory process, etc. producing reactive oxygen species (ROS and physical damage (e.g., wounds, sunburns also resulting in reactive oxygen species production. Although skin is equipped with an array of defense mechanisms to counteract reactive oxygen species, augmented exposure and continued reactive oxygen species might result in excessive oxidative stress leading to many skin disorders including inflammatory diseases, pigmenting disorders and some types of cutaneous malignancy. The nuclear factor erythroid 2-related factor 2 (Nrf2 is an emerging regulator of cellular resistance and of defensive enzymes such as the phase II enzymes. Induction of the Keap1–Nrf2 pathway may have a beneficial effect in the treatment of a large number of skin disorders by stimulating an endogenous defense mechanism. However, prolonged and enhanced activation of this pathway is detrimental and, thus, limits the therapeutic potential of Keap1–Nrf2 modulators. Here, we review the consequences of oxidative stress to the skin, and the defense mechanisms that skin is equipped with. We describe the challenges of maintaining skin redox balance and its impact on skin status and function. Finally, we suggest a novel strategy for maintenance of skin redox homeostasis by modulating the Keap1–Nrf2 pathway using nanotechnology-based delivery systems.

  1. Waste assay and mass balance for the decontamination and volume reduction system at LANL

    Energy Technology Data Exchange (ETDEWEB)

    Gruetzmacher, Kathleen M.; Ferran, Scott G.; Garner, Scott E.; Romero, Mike J.; Christensen, Davis V.; Bustos, Roland M.

    2003-07-01

    The Decontamination and Volume Reduction System (DVRS) operated by the Solid Waste Operations (SWO) Group at Los Alamos National Laboratory (LANL) processes large volume, legacy radioactive waste items. Waste boxes, in sizes varying from 4 ft x 4 ft x 8 ft to 10 ft x 12 ft x 40 ft, are assayed prior to entry into the processing building. Inside the building, the waste items are removed from their container, decontaminated and/or size reduced if necessary, and repackaged for shipment to the Waste Isolation Pilot Plant (WIPP) or on-site low-level waste disposal. The repackaged items and any secondary waste produced (e.g., personal protective equipment) are assayed again at the end of the process and a mass balance is done to determine whether there is any significant hold-up material left in the DVRS building. The DVRS building is currently classed as a radiological facility, with a building limit of 0.52 Ci of Pu239 and Am241, and 0.62 Ci of Pu238, the most common radionuclides processed. This requires tight controls on the flow of nuclear material. The large volume of the initial waste packages, the (relatively) small amounts of radioactive material in them, and the tight ceiling on the building inventory require accurate field measurements of the nuclear material. This paper describes the radioactive waste measurement techniques, the computer modeling used to determine the amount of nuclear material present in a waste package, the building inventory database, and the DVRS process itself. Future plans include raising the limit on the nuclear material inventory allowed in the building to accommodate higher activity waste packages. All DOE sites performing decontamination and decommissioning of radioactive process equipment face challenges related to waste assay and inventory issues. This paper describes an ongoing operation, incorporating lessons learned over the life of the project to date.

  2. Immunotherapy: Shifting the Balance of Cell-Mediated Immunity and Suppression in Human Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tucker, Jo A.; Jochems, Caroline [Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Gulley, James L. [Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Schlom, Jeffrey, E-mail: js141c@nih.gov; Tsang, Kwong Y. [Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States)

    2012-12-11

    Active immunotherapy is dependent on the ability of the immune system to recognize and respond to tumors. Despite overwhelming evidence to support a cell-mediated immune response to prostate cancer, it is insufficient to eradicate the disease. This is likely due to a high level of suppression at the tumor site from a variety of sources, including immunosuppressive cells. Immune cells entering the tumor microenvironment may be inhibited directly by the tumor, stromal cells or other immune cells that have been induced to adopt a suppressive phenotype. The resurgence of interest in immunotherapy following the approval of sipuleucel-T and ipilimumab by the Food and Drug Administration has brought about new strategies for overcoming tumor-mediated suppression and bolstering anti-tumor responses. Improved understanding of the immune response to prostate cancer can lead to new combination therapies, such as the use of vaccine with small molecule and checkpoint inhibitors or other immunotherapies.

  3. Immunotherapy: Shifting the Balance of Cell-Mediated Immunity and Suppression in Human Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Jeffrey Schlom

    2012-12-01

    Full Text Available Active immunotherapy is dependent on the ability of the immune system to recognize and respond to tumors. Despite overwhelming evidence to support a cell-mediated immune response to prostate cancer, it is insufficient to eradicate the disease. This is likely due to a high level of suppression at the tumor site from a variety of sources, including immunosuppressive cells. Immune cells entering the tumor microenvironment may be inhibited directly by the tumor, stromal cells or other immune cells that have been induced to adopt a suppressive phenotype. The resurgence of interest in immunotherapy following the approval of sipuleucel-T and ipilimumab by the Food and Drug Administration has brought about new strategies for overcoming tumor-mediated suppression and bolstering anti-tumor responses. Improved understanding of the immune response to prostate cancer can lead to new combination therapies, such as the use of vaccine with small molecule and checkpoint inhibitors or other immunotherapies.

  4. Sex differences in the human visual system.

    Science.gov (United States)

    Vanston, John E; Strother, Lars

    2017-01-02

    This Mini-Review summarizes a wide range of sex differences in the human visual system, with a primary focus on sex differences in visual perception and its neural basis. We highlight sex differences in both basic and high-level visual processing, with evidence from behavioral, neurophysiological, and neuroimaging studies. We argue that sex differences in human visual processing, no matter how small or subtle, support the view that females and males truly see the world differently. We acknowledge some of the controversy regarding sex differences in human vision and propose that such controversy should be interpreted as a source of motivation for continued efforts to assess the validity and reliability of published sex differences and for continued research on sex differences in human vision and the nervous system in general. © 2016 Wiley Periodicals, Inc.

  5. Benchmarking Non-Hardware Balance of System (Soft) Costs for U.S. Photovoltaic Systems Using a Data-Driven Analysis from PV Installer Survey Results

    Energy Technology Data Exchange (ETDEWEB)

    Ardani, K.; Barbose, G.; Margolis, R.; Wiser, R.; Feldman, D.; Ong, S.

    2012-11-01

    This report presents results from the first U.S. Department of Energy (DOE) sponsored, bottom-up data-collection and analysis of non-hardware balance-of-system costs--often referred to as 'business process' or 'soft' costs--for residential and commercial photovoltaic (PV) systems.

  6. Human System Risk Management for Space Flight

    Science.gov (United States)

    Davis, Jeffrey

    2015-01-01

    This brief abstract reviews the development of the current day approach to human system risk management for space flight and the development of the critical components of this process over the past few years. The human system risk management process now provides a comprehensive assessment of each human system risk by design reference mission (DRM) and is evaluated not only for mission success but also for long-term health impacts for the astronauts. The discipline of bioastronautics is the study of the biological and medical effects of space flight on humans. In 1997, the Space Life Sciences Directorate (SLSD) initiated the Bioastronautics Roadmap (Roadmap) as the "Critical Path Roadmap", and in 1998 participation in the roadmap was expanded to include the National Space Biomedical Research Institute (NSBRI) and the external community. A total of 55 risks and 250 questions were identified and prioritized and in 2000, the Roadmap was base-lined and put under configuration control. The Roadmap took into account several major advisory committee reviews including the Institute of Medicine (IOM) "Safe Passage: Astronaut care for Exploration Missions", 2001. Subsequently, three collaborating organizations at NASA HQ (Chief Health and Medical Officer, Office of Space Flight and Office of Biological & Physical Research), published the Bioastronautics Strategy in 2003, that identified the human as a "critical subsystem of space flight" and noted that "tolerance limits and safe operating bands must be established" to enable human space flight. These offices also requested a review by the IOM of the Roadmap and that review was published in October 2005 as "A Risk Reduction Strategy for Human Exploration of Space: A Review of NASA's Bioastronautics Roadmap", that noted several strengths and weaknesses of the Roadmap and made several recommendations. In parallel with the development of the Roadmap, the Office of the Chief Health and Medical Officer (OCHMO) began a process in

  7. Perceptions of Nebraska Teachers Regarding the Transition from STARS to NeSA and Its Perceived Influence on the Implementation of a Balanced Assessment System

    Science.gov (United States)

    Isom, Jamie

    2012-01-01

    The purpose of this explanatory mixed methods study was to explore the perceptions of Nebraska teachers about their experiences in the transition from STARS to NeSA. The study explored their perceptions of the influence of the transition on implementation of a balanced assessment system. As defined by NDE, a balanced system included NeSA testing,…

  8. Simplification of heating systems by omitting circulating pumps and differential pressure regulating valves. Balancing; Vereinfachung durch Einsparung von Umwaelzpumpen und Differenzdruckregler. Hydraulischer Abgleich

    Energy Technology Data Exchange (ETDEWEB)

    Gebauer, Marc [Baelz W. und Sohn GmbH und Co., Berlin (Germany)

    2011-07-01

    Balancing of heating systems today is possible without differential pressure regulating valves. Only the design basis volume flow is adjusted at the sectioning valve of the heating section, while the part-load behaviour is regulated accurately via thermal power regulation. This simplifies balancing, and the total efficiency of systems will be better than with the commonly used differential pressure regulating valves.

  9. Human performance modeling for system of systems analytics.

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, Kevin R.; Lawton, Craig R.; Basilico, Justin Derrick; Longsine, Dennis E. (INTERA, Inc., Austin, TX); Forsythe, James Chris; Gauthier, John Henry; Le, Hai D.

    2008-10-01

    A Laboratory-Directed Research and Development project was initiated in 2005 to investigate Human Performance Modeling in a System of Systems analytic environment. SAND2006-6569 and SAND2006-7911 document interim results from this effort; this report documents the final results. The problem is difficult because of the number of humans involved in a System of Systems environment and the generally poorly defined nature of the tasks that each human must perform. A two-pronged strategy was followed: one prong was to develop human models using a probability-based method similar to that first developed for relatively well-understood probability based performance modeling; another prong was to investigate more state-of-art human cognition models. The probability-based modeling resulted in a comprehensive addition of human-modeling capability to the existing SoSAT computer program. The cognitive modeling resulted in an increased understanding of what is necessary to incorporate cognition-based models to a System of Systems analytic environment.

  10. Evaluating Human Factors in Augmented Reality Systems

    Science.gov (United States)

    2005-12-01

    user’s location and then per- forming the (cognitive) task of Mark A. Livingston Naval Research Laboratory Evaluating Human Factors in Augmented Reality ...00-00-2005 4. TITLE AND SUBTITLE Evaluating Human Factors in Augmented Reality Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...the basis for situation awareness or—in combina- tion with visual cues—a navigation task. Tactile tasks. Via haptic devices, we can apply vir- tual

  11. Fall proof: improving mobility and balance Elizabeth Best-Martini Fall proof: improving mobility and balance and Kim A Botenhagen-Di Genova Human Kinetics £24.50 0 73603 687 3 0736036873 Debra Rose Human Kinetics £38 0 73604 088 9 0736040889.

    Science.gov (United States)

    2003-09-01

    A structured balance and mobility-training programme specifically designed to reduce physical frailty and the rising incidence of falls among older people. This practical manual blends theory into practical applications and covers an introduction to the body systems, balance assessments and a discussion of contemporary motor learning principles. Tel: Customer Services 0113 255 5665. Email: hk@hkeurope.com.

  12. Human behavior in online social systems

    Science.gov (United States)

    Grabowski, A.

    2009-06-01

    We present and study data concerning human behavior in four online social systems: (i) an Internet community of friends of over 107 people, (ii) a music community website with over 106 users, (iii) a gamers’ community server with over 5 × 106 users and (iv) a booklovers’ website with over 2.5 × 105 users. The purpose of those systems is different; however, their properties are very similar. We have found that the distribution of human activity (e.g., the sum of books read or songs played) has the form of a power law. Moreover, the relationship between human activity and time has a power-law form, too. We present a simple interest-driven model of the evolution of such systems which explains the emergence of two scaling regimes.

  13. HUMAN MASS BALANCE STUDY OF TAS-102 USING 14C ANALYZED BY ACCELERATOR MASS SPECTROMETRY

    Science.gov (United States)

    Lee, James J.; Seraj, Jabed; Yoshida, Kenichiro; Mizuguchi, Hirokazu; Strychor, Sandra; Fiejdasz, Jillian; Faulkner, Tyeler; Parise, Robert A.; Fawcett, Patrick; Pollice, Laura; Mason, Scott; Hague, Jeremy; Croft, Marie; Nugteren, James; Tedder, Charles; Sun, Weijing; Chu, Edward; Beumer, Jan Hendrik

    2016-01-01

    Background TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite. TPI inhibits degradation of FTD by TP, increasing systemic exposure to FTD. Methods Patients with advanced solid tumors (6 M/2 F; median age 58 years; PS 0–1) were enrolled on this study. Patients in group A (N = 4) received 60 mg TAS-102 with 200 nCi [14C]-FTD, while patients in group B (N = 4) received 60 mg TAS-102 with 1000 nCi [14C]-TPI orally. Plasma, blood, urine, feces, and expired air (group A only) were collected up to 168 h, and were analyzed for 14C by accelerator mass spectrometry and analytes by LC-MS/MS. Results FTD: 59.8% of the 14C dose was recovered; 54.8% in urine mostly as FTY and FTD glucuronide isomers. The extractable radioactivity in the pooled plasma consisted of 52.7% FTD and 33.2% FTY. TPI: 76.8% of the 14C dose was recovered; 27.0% in urine mostly as TPI, and 49.7% in feces. The extractable radioactivity in the pooled plasma consisted of 53.1% TPI and 30.9% 6-HMU, the major metabolite of TPI. Conclusion Absorbed 14C-FTD was metabolized and mostly excreted in urine. The majority of 14C-TPI was recovered in feces, and the majority of absorbed TPI was excreted in urine. The current data with the ongoing hepatic and renal dysfunction studies will provide an enhanced understanding of the TAS-102 elimination profile. PMID:26787503

  14. Human mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometry.

    Science.gov (United States)

    Lee, James J; Seraj, Jabed; Yoshida, Kenichiro; Mizuguchi, Hirokazu; Strychor, Sandra; Fiejdasz, Jillian; Faulkner, Tyeler; Parise, Robert A; Fawcett, Patrick; Pollice, Laura; Mason, Scott; Hague, Jeremy; Croft, Marie; Nugteren, James; Tedder, Charles; Sun, Weijing; Chu, Edward; Beumer, Jan Hendrik

    2016-03-01

    TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite. TPI inhibits degradation of FTD by TP, increasing systemic exposure to FTD. Patients with advanced solid tumors (6 M/2 F; median age 58 years; PS 0-1) were enrolled on this study. Patients in group A (N = 4) received 60 mg TAS-102 with 200 nCi [(14)C]-FTD, while patients in group B (N = 4) received 60 mg TAS-102 with 1000 nCi [(14)C]-TPI orally. Plasma, blood, urine, feces, and expired air (group A only) were collected up to 168 h and were analyzed for (14)C by accelerator mass spectrometry and analytes by LC-MS/MS. FTD: 59.8% of the (14)C dose was recovered: 54.8% in urine mostly as FTY and FTD glucuronide isomers. The extractable radioactivity in the pooled plasma consisted of 52.7% FTD and 33.2% FTY. TPI: 76.8% of the (14)C dose was recovered: 27.0% in urine mostly as TPI and 49.7% in feces. The extractable radioactivity in the pooled plasma consisted of 53.1% TPI and 30.9% 6-HMU, the major metabolite of TPI. Absorbed (14)C-FTD was metabolized and mostly excreted in urine. The majority of (14)C-TPI was recovered in feces, and the majority of absorbed TPI was excreted in urine. The current data with the ongoing hepatic and renal dysfunction studies will provide an enhanced understanding of the TAS-102 elimination profile.

  15. The complement system in human cardiometabolic disease.

    Science.gov (United States)

    Hertle, E; Stehouwer, C D A; van Greevenbroek, M M J

    2014-10-01

    The complement system has been implicated in obesity, fatty liver, diabetes and cardiovascular disease (CVD). Complement factors are produced in adipose tissue and appear to be involved in adipose tissue metabolism and local inflammation. Thereby complement links adipose tissue inflammation to systemic metabolic derangements, such as low-grade inflammation, insulin resistance and dyslipidaemia. Furthermore, complement has been implicated in pathophysiological mechanisms of diet- and alcohol induced liver damage, hyperglycaemia, endothelial dysfunction, atherosclerosis and fibrinolysis. In this review, we summarize current evidence on the role of the complement system in several processes of human cardiometabolic disease. C3 is the central component in complement activation, and has most widely been studied in humans. C3 concentrations are associated with insulin resistance, liver dysfunction, risk of the metabolic syndrome, type 2 diabetes and CVD. C3 can be activated by the classical, the lectin and the alternative pathway of complement activation; and downstream activation of C3 activates the terminal pathway. Complement may also be activated via extrinsic proteases of the coagulation, fibrinolysis and the kinin systems. Studies on the different complement activation pathways in human cardiometabolic disease are limited, but available evidence suggests that they may have distinct roles in processes underlying cardiometabolic disease. The lectin pathway appeared beneficial in some studies on type 2 diabetes and CVD, while factors of the classical and the alternative pathway were related to unfavourable cardiometabolic traits. The terminal complement pathway was also implicated in insulin resistance and liver disease, and appears to have a prominent role in acute and advanced CVD. The available human data suggest a complex and potentially causal role for the complement system in human cardiometabolic disease. Further, preferably longitudinal studies are needed to

  16. Application of new novel energy balance method to strongly nonlinear oscillator systems

    Directory of Open Access Journals (Sweden)

    Md. Abdur Razzak

    2015-01-01

    Full Text Available In this paper, a new novel energy balance method based on the harmonic balance method is proposed to obtain higher-order approximations of strongly nonlinear problems arising in engineering. Especially, second-order approximation is considered in this paper. Results found in this paper are compared with the exact result and other existing results. The results show that the proposed method gives better result for both small and large amplitudes of oscillation than other existing results. The method is illustrated by examples. It has been shown that the proposed method is very effective, convenient and quite accurate to nonlinear engineering problems.

  17. Effects of a Passive Online Software Application on Heart Rate Variability and Autonomic Nervous System Balance

    Science.gov (United States)

    2017-01-01

    . This may be the first RCT to show that specific frequencies of a purported non-Hertzian type of subtle energy conveyed by software applications broadcast from personal electronic devices can be bioactive and beneficially impact autonomic nervous system balance. PMID:28051874

  18. Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells.

    Science.gov (United States)

    Alvarez, Yolanda; Rodríguez, Mario; Municio, Cristina; Hugo, Etzel; Alonso, Sara; Ibarrola, Nieves; Fernández, Nieves; Crespo, Mariano Sánchez

    2012-10-12

    Stimulation of human dendritic cells with the fungal surrogate zymosan produces IL-23 and a low amount of IL-12 p70. Trans-repression of il12a transcription, which encodes IL-12 p35 chain, by proteins of the Notch family and lysine deacetylation reactions have been reported as the underlying mechanisms, but a number of questions remain to be addressed. Zymosan produced the location of sirtuin 1 (SIRT1) to the nucleus, enhanced its association with the il12a promoter, increased the nuclear concentration of the SIRT1 co-substrate NAD(+), and decreased chromatin accessibility in the nucleosome-1 of il12a, which contains a κB-site. The involvement of deacetylation reactions in the inhibition of il12a transcription was supported by the absence of Ac-Lys-14-histone H3 in dendritic cells treated with zymosan upon coimmunoprecipitation of transducin-like enhancer of split. In contrast, we did not obtain evidence of a possible effect of SIRT1 through the deacetylation of c-Rel, the central element of the NF-κB family involved in il12a regulation. These data indicate that an enhancement of SIRT1 activity in response to phagocytic stimuli may reduce the accessibility of c-Rel to the il12a promoter and its transcriptional activation, thus regulating the IL-12 p70/IL-23 balance and modulating the ongoing immune response.

  19. Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells*

    Science.gov (United States)

    Alvarez, Yolanda; Rodríguez, Mario; Municio, Cristina; Hugo, Etzel; Alonso, Sara; Ibarrola, Nieves; Fernández, Nieves; Crespo, Mariano Sánchez

    2012-01-01

    Stimulation of human dendritic cells with the fungal surrogate zymosan produces IL-23 and a low amount of IL-12 p70. Trans-repression of il12a transcription, which encodes IL-12 p35 chain, by proteins of the Notch family and lysine deacetylation reactions have been reported as the underlying mechanisms, but a number of questions remain to be addressed. Zymosan produced the location of sirtuin 1 (SIRT1) to the nucleus, enhanced its association with the il12a promoter, increased the nuclear concentration of the SIRT1 co-substrate NAD+, and decreased chromatin accessibility in the nucleosome-1 of il12a, which contains a κB-site. The involvement of deacetylation reactions in the inhibition of il12a transcription was supported by the absence of Ac-Lys-14-histone H3 in dendritic cells treated with zymosan upon coimmunoprecipitation of transducin-like enhancer of split. In contrast, we did not obtain evidence of a possible effect of SIRT1 through the deacetylation of c-Rel, the central element of the NF-κB family involved in il12a regulation. These data indicate that an enhancement of SIRT1 activity in response to phagocytic stimuli may reduce the accessibility of c-Rel to the il12a promoter and its transcriptional activation, thus regulating the IL-12 p70/IL-23 balance and modulating the ongoing immune response. PMID:22893703

  20. Water and sediment quality, nutrient biochemistry and pollution loads in an urban freshwater lake: balancing human and ecological services.

    Science.gov (United States)

    Waltham, Nathan J; Reichelt-Brushett, Amanda; McCann, Damian; Eyre, Bradley D

    2014-12-01

    Optimizing the utility of constructed waterways as residential development with water-frontage, along with a productive and functional habitat for wildlife is of considerable interest to managers. This study examines Lake Hugh Muntz, a large (17 ha) freshwater lake built in Gold Coast City, Australia. A ten year water quality monitoring programme shows that the lake has increasing nutrient concentrations, and together with summer algal blooms, the lake amenity as a popular recreational swimming and triathlon training location is at risk. A survey of fish and aquatic plant communities showed that the lake supports a sub-set of species found in adjacent natural wetlands. Sediment contaminants were below the lower Australian trigger values, except As, Hg, Pb and Zn, probably a function of untreated and uncontrolled stormwater runoff from nearby urban roads. Sediment biogeochemistry showed early signs of oxygen depletion, and an increase in benthic organic matter decomposition and oxygen consumption will result in more nitrogen recycled to the water column as NH4(+) (increasing the intensity of summer algal blooms) and less nitrogen lost to the atmosphere as N2 gas via denitrification. A series of catchment restoration initiatives were modeled and the optimal stormwater runoff restoration effort needed for lake protection will be costly, particularly retrospective, as is the case here. Overall, balancing the lifestyles and livelihoods of residents along with ecosystem protection are possible, but require considerable trade-offs between ecosystem services and human use.