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Sample records for human apo a-iv

  1. Plasma metabolism of apolipoprotein A-IV in humans

    International Nuclear Information System (INIS)

    Ghiselli, G.; Krishnan, S.; Beigel, Y.; Gotto, A.M. Jr.

    1986-01-01

    As assessed by molecular sieve chromatography and quantitation by a specific radioimmunoassay, apoA-IV is associated in plasma with the triglyceride-rich lipoproteins, to a high density lipoprotein (HDL) subfraction of smaller size than HDL3, and to the plasma lipoprotein-free fraction (LFF). In this study, the turnover of apoA-IV associated to the triglyceride-rich lipoproteins, HDL and LFF was investigated in vivo in normal volunteers. Human apoA-IV isolated from the thoracic duct lymph chylomicrons was radioiodinated and incubated with plasma withdrawn from normal volunteers after a fatty meal. Radioiodinated apoA-IV-labeled triglyceride-rich lipoproteins, HDL, and LFF were then isolated by chromatography on an AcA 34 column. Shortly after the injection of the radioiodinated apoA-IV-labeled triglyceride-rich lipoproteins, most of the radioactivity could be recovered in the HDL and LFF column fractions. On the other hand, when radioiodinated apoA-IV-labeled HDL or LFF were injected, the radioactivity remained with the originally injected fractions at all times. The residence time in plasma of 125 I-labeled apoA-IV, when injected in association with HDL or LFF, was 1.61 and 0.55 days, respectively. When 125 I-labeled apoA-IV was injected as a free protein, the radioactivity distributed rapidly among the three plasma pools in proportion to their mass. The overall fractional catabolic rate of apoA-IV in plasma was measured in the three normal subjects and averaged 1.56 pools per day. The mean degradation rate of apoA-IV was 8.69 mg/kg X day

  2. Polymorphisme de l'APO A-IV chez les togolais: fréquences et ...

    African Journals Online (AJOL)

    Le polymorphisme génétique de l'apolipoprotéine A-IV (apo A-IV) a été étudié chez 601 togolais dont 252 sujets d'un isolat relatif, les Adélé et 349 sujets des ethnies, Ewé, Mina, Ouatchi originaires de la côte atlantique. La détermination des phénotypes a été réalisée par isoélectrofocalisation (IEF) sur gel de ...

  3. Improving the diffraction of apoA-IV crystals through extreme dehydration

    International Nuclear Information System (INIS)

    Deng, Xiaodi; Davidson, W. Sean; Thompson, Thomas B.

    2011-01-01

    Apolipoprotein A-IV crystals consisted of a long unit-cell edge (540 Å) with a high mosaic spread, making them intractable for X-ray diffraction analysis. Extreme dehydration in 60% PEG 3350 was utilized as a post-crystallization treatment as well a screening method to significantly sharpen the mosaic spread and increase the overall resolution of diffraction. Apolipoproteins are the protein component of high-density lipoproteins (HDL), which are necessary for mobilizing lipid-like molecules throughout the body. Apolipoproteins undergo self-association, especially at higher concentrations, making them difficult to crystallize. Here, the crystallization and diffraction of the core fragment of apolipoprotein A-IV (apoA-IV), consisting of residues 64–335, is presented. ApoA-IV 64–335 crystallized readily in a variety of hexagonal (P6) morphologies with similar unit-cell parameters, all containing a long axis of nearly 550 Å in length. Preliminary diffraction experiments with the different crystal morphologies all resulted in limited streaky diffraction to 3.5 Å resolution. Crystal dehydration was applied to the different morphologies with variable success and was also used as a quality indicator of crystal-growth conditions. The results show that the morphologies that withstood the most extreme dehydration conditions showed the greatest improvement in diffraction. One morphology in particular was able to withstand dehydration in 60% PEG 3350 for over 12 h, which resulted in well defined intensities to 2.7 Å resolution. These results suggest that the approach of integrating dehydration with variation in crystal-growth conditions might be a general technique to optimize diffraction

  4. Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention.

    Science.gov (United States)

    Keeney, Jeriel Thomas-Richard; Ibrahimi, Shaher; Zhao, Liqin

    2015-01-01

    Three major genetic isoforms of apolipoprotein E (ApoE), ApoE2, ApoE3, and ApoE4, exist in humans and lead to differences in susceptibility to Alzheimer's disease (AD). This study investigated the impact of human ApoE isoforms on brain metabolic pathways involved in glucose utilization and amyloid-β (Aβ) degradation, two major areas that are significantly perturbed in preclinical AD. Hippocampal RNA samples from middle-aged female mice with targeted human ApoE2, ApoE3, and ApoE4 gene replacement were comparatively analyzed with a qRT-PCR custom array for the expression of 85 genes involved in insulin/insulin-like growth factor (Igf) signaling. Consistent with its protective role against AD, ApoE2 brain exhibited the most metabolically robust profile among the three ApoE genotypes. When compared to ApoE2 brain, both ApoE3 and ApoE4 brains exhibited markedly reduced levels of Igf1, insulin receptor substrates (Irs), and facilitated glucose transporter 4 (Glut4), indicating reduced glucose uptake. Additionally, ApoE4 brain exhibited significantly decreased Pparg and insulin-degrading enzyme (Ide), indicating further compromised glucose metabolism and Aβ dysregulation associated with ApoE4. Protein analysis showed significantly decreased Igf1, Irs, and Glut4 in ApoE3 brain, and Igf1, Irs, Glut4, Pparg, and Ide in ApoE4 brain compared to ApoE2 brain. These data provide the first documented evidence that human ApoE isoforms differentially affect brain insulin/Igf signaling and downstream glucose and amyloid metabolic pathways, illustrating a potential mechanism for their differential risk in AD. A therapeutic strategy that enhances brain insulin/Igf1 signaling activity to a more robust ApoE2-like phenotype favoring both energy production and amyloid homeostasis holds promise for AD prevention and early intervention.

  5. Management and research priorities of NASA 'Human Research Program'

    International Nuclear Information System (INIS)

    Zhou Weijun; Diao Tianxi; Li Lijuan; Li Zulan

    2013-01-01

    Research on humans has been the focus of the United States space biomedical research, while 'Human Research Program', as an important project initiated by NASA, aims to reduce the risks to the health and performance of astronauts. This paper analyzed this project in terms of organization and management, funding investment and research directions. (authors)

  6. Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.

    Science.gov (United States)

    Bour, Alexandra; Grootendorst, Jeannette; Vogel, Elise; Kelche, Christian; Dodart, Jean-Cosme; Bales, Kelly; Moreau, Pierre-Henri; Sullivan, Patrick M; Mathis, Chantal

    2008-11-21

    Apolipoprotein (apo) E4, one of three human apoE (h-apoE) isoforms, has been identified as a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. However, the biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent role of apoE in cognitive processes was studied in human apoE targeted-replacement (TR) mice. These mice express either the human apoE3 or apoE4 gene under the control of endogenous murine apoE regulatory sequences, resulting in physiological expression of h-apoE in both a temporal and spatial pattern similar to humans. Male and female apoE3-TR, apoE4-TR, apoE-knockout and C57BL/6J mice (15-18 months) were tested with spatial memory and avoidance conditioning tasks. Compared to apoE3-TR mice, spatial memory in female apoE4-TR mice was impaired based on their poor performances in; (i) the probe test of the water-maze reference memory task, (ii) the water-maze working memory task and (iii) an active avoidance Y-maze task. Retention performance on a passive avoidance task was also impaired in apoE4-TR mice, but not in other genotypes. These deficits in both spatial and avoidance memory tasks may be related to the anatomical and functional abnormalities previously reported in the hippocampus and the amygdala of apoE4-TR mice. We conclude that the apoE4-TR mice provide an excellent model for understanding the mechanisms underlying apoE4-dependent susceptibility to cognitive decline.

  7. Persistent organochlorine pollutants and risk for skeletal fractures and impaired bone mineral density in humans. Results from the ''COMPARE'' project

    Energy Technology Data Exchange (ETDEWEB)

    Hagmar, L.; Wallin, E.; Joensson, B.A. [Department of Occupational and Environmental Medicine, Lund (Sweden)

    2004-09-15

    Persistent organochlorine pollutants (POP) have, in animal studies, impaired normal bone metabolism and resulted in increased bone fragility. Especially considering the dramatical increase in osteoporotic fractures in western societies during the last decades, it is a pertinent question whether a high dietary intake of POP might pose a risk for deteriorated bone quality in humans. This problem has been assessed as a part of the collaborative project ''COMPARE'', funded by European Commission RD Life Science Program. As a study base we have used cohorts of Swedish fishermen's families. We have earlier shown that fishermen living at the east coast of Sweden, have a high consumption of contaminated fatty fish from the Baltic Sea and consequently relatively high exposure levels for various POPs, also compared with fishermen from the Swedish west coast. Such a discrepancy was also found for fishermen's wives. The aim of the project was to assess in epidemiological studies whether a high dietary intake of POP through fatty fish from the Baltic may result in an increased incidence of osteoporotic fractures or decreased bone mineral density (BMD). We give here an overview of the results.

  8. Both apoB-48 and apoB-100 are synthesized by human enterocytes and secreted in hepatic bile

    International Nuclear Information System (INIS)

    Rochette, C.; Bendayan, M.; Roy, C.C.; Milne, R.; Marcel, Y.; Levy, E.

    1990-01-01

    Using high resolution immunogold technique with polyclonal and monoclonal antibodies, the authors were able to show the presence of both forms of apoB (B-48 and B-100) in human enterocytes. Labeling for both isoproteins was present not only over the rough endoplasmic reticulum, but also on the apical vesicles, in multivesicular bodies and on microvilli indicated an internalization of apoB from the gut lumen. To examine the synthesis of apoB-100, a pulse of [ 3 H]-leucine was administered to human segments of intestine in explant culture. Newly synthesized apoB-100, confirmed by immunoprecipitation and immunoblot, represented 28% of total apoB production. The hypothesis that apoB-100 might be secreted in bile and internalized by the intestine, was tested by measuring apoB in human hepatic bile. The expression and immunoreactivity of both forms of apoB were obtained by using monoclonal antibodies which identify both B-48 and B-100 (1D1 and 2D8) or B-100 alone (3A10, 4G3, 5E11 and 22). While no epitopes were detected by 2D8 and 4G3, the distribution pattern for apoB was found by 1D1 (7.3%), 3A10 (31.2%), 5E11 (46.2%) and 22 (14.0%), suggesting that apoB fragments are secreted in bile. These findings provide evidence that apoB-100 is synthesized by the human gut and show that both isoproteins are consistent with the possibility that biliary apoB may be internalized by the enterocyte

  9. Photoluminescence of acupoint 'Waiqiu' in human superficial fascia

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yuan [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Yan Xiaohui [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Liu Chenglin [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Dang Ruishan [Second Military Medical University, Shanghai 200433 (China); Zhang Xinyi [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China) and Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203 (China)]. E-mail: xy-zhang@fudan.edu.cn

    2006-07-15

    The spectral characters of an acupuncture point named 'Waiqiu' in superficial fascia tissue have been studied by photoluminescence (PL) spectroscopy under the excitation of 457.9 nm. The PL around 'Waiqiu' acupuncture point consists of two sub-bands resulting from the flavin adenine dinucleotide (FAD) and phospholipids, and the porphyrins (including purine, isoxanthopterin and tryptophan), respectively. More emission due to FAD and phospholipids is found inside the acupuncture effect area of 'Waiqiu' than its marginal or outside acupuncture regions. The ratio of emission intensity of FAD and phospholipids to one of porphyrins gradually decreases along the direction away from the center of the acupuncture point. It implies that the component proportion changes between FAD, phospholipids and porphyrins around the 'Waiqiu' acupuncture point. We suggest that there might be a certain relationship between redox function of FAD and 'Waiqiu' acupuncture effect.

  10. A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD

    DEFF Research Database (Denmark)

    Fujihara, Masashi; Bartels, Emil; Nielsen, Lars B

    2009-01-01

    changes consistent with early human AMD including loss of basal infoldings and accumulation of cytoplasmic vacuoles in the RPE, and basal laminar deposits containing long-spacing collagen and heterogeneous debris in Bruch membrane of apoB100 mice. In apoB100 mice given a high-fat diet, basal linear...... transgenic for a human genomic fragment encoding the full length human apoB ("apoB100" mice) and litter-mate control mice were given a normal chow or high-fat diet for 12 months. Mice were evaluated for human apoB mRNA expression in the RPE/choroid and liver by RT-qPCR. Phenotypic changes associated......-like deposits were identified in 12-month-old mice. Linear regression analysis showed that the genotype (human apoB transgene) was a stronger influencing factor than high-fat diet in producing AMD-like lesions used in this study. Human apoB100 transgenic mice overexpress apoB in RPE and, with time, develop...

  11. Apolipoprotein A-IV inhibits AgRP/NPY neurons and activates POMC neurons in the arcuate nucleus

    Science.gov (United States)

    Apolipoprotein A-IV (apoA-IV) in the brain potently suppresses food intake. However the mechanisms underlying its anorexigenic effects remain to be identified. We first examined the effects of apoA-IV on cellular activities in hypothalamic neurons that co-express agouti-related peptide (AgRP) and ne...

  12. Exposure to CB-153 and p,p'-DDE and human sperm chromatin integrity

    Energy Technology Data Exchange (ETDEWEB)

    Rignell-Hydbom, A.; Rylander, L.; Joensson, B.A.G.; Hagmar, L. [Dept. of Occupational and Environmental Medicine, Lund Univ. Hospital (Sweden); Giwercman, A. [Fertility Centre, Malmoe Univ. hospital (Sweden); Spano, M. [Section of Toxicology and Biomedical Sciences, ENEA Casaccia Research Centre, Rome (Italy)

    2004-09-15

    In Sweden, the consumption of fatty fish from the Baltic Sea (off the Swedish east coast) is the single most important source of exposure to persistent organochlorine pollutants (POPs). Fishermen from the east coast have averagely higher plasma levels of polychlorinated biphenyls (PCBs) and total POP derived TEQ in plasma than both west coast fishermen and men from the general population. Dichlorodiphenyl dichloroethene (p,p'-DDE), a relevant biomarker for POP is still present in relatively high serum concentrations in men consuming fish from the Baltic Sea. Several studies have shown that POPs are capable of interfering with reproductive and endocrine function in animals. Human studies have shown that exposure to PCBs and polychlorinated dibenzofurans (PCDFs) has a negative effect on male reproductive function, and especially sperm motility seems vulnerable. However, studies relating to human sperm genetic integrity are few. The aim of the study was to investigate whether exposure to POP using 2,2',4,4',5,5'- hexachlorobiphenyl (CB-153) and p,p'-DDE as biomarkers, are associated with sperm chromatin integrity. In order to ensure a sufficient variation in POP exposure fishermen from both the Swedish east (''more exposed'') and west coasts (''less exposed'') formed the study base.

  13. Impacts of office design characteristics on human energy expenditure: developing a ''KINESIS'' model

    Energy Technology Data Exchange (ETDEWEB)

    Rassia, Stamatina T.; Baker, Nick V. [University of Cambridge, Martin Centre for Architectural and Urban Studies, Department of Architecture, Cambridge (United Kingdom); Alexiou, Alexandros [University of Cambridge, Department of Land Economy, Cambridge (United Kingdom)

    2011-03-15

    Over the last few decades, research in public health has associated inactivity with a number of ailments and chronic diseases, such as colon cancer, type II diabetes, osteoporosis and coronary heart disease. In the belief that the office building substantially shapes occupant daily activity, this work draws upon qualitative and quantitative monitoring of human activity within office buildings during typical working weeks. This research is based on data collection results regarding the design of space in relation to energy expenditure and it presents a quantitative model (named KINESIS after the Greek word for activity) that, in the form of a set equation, can simulate and estimate the total energy expenditure per person per day in a given office layout. (orig.)

  14. Gunning for accuracy: Company targets human error with 'foolproof' perforating gun

    Energy Technology Data Exchange (ETDEWEB)

    Ross, E.

    2002-12-01

    An innovative new design for a scalloped expandable perforating gun is described. The gun is manufactured in Edmonton by LRI Perforating Systems, and it aimed at reducing the chances of human error that can result in sub-optimal performance. A perforating gun is used to pierce the well's casing to allow hydrocarbons to flow into the wellbore. It consists of a carrier, a pipe with an eighth-inch thick wall that protects the explosives downhole, and an inner tube containing the explosives. The LRI system has a unique interlocking mechanism for the end plates, which are attached to either end of the thin-walled charge holder tube, in addition to other advantageous features, including a price advantage of 10 to 15 per cent. Marketing strategy is designed to interest wi reline companies that focus on vertical well applications. 1 photo.

  15. Are Sciences Essential and Humanities Elective? Disentangling Competing Claims for Humanities' Research Public Value

    Science.gov (United States)

    Olmos-Peñuela, Julia; Benneworth, Paul; Castro-Martínez, Elena

    2015-01-01

    Recent policy discourse suggests that arts and humanities research is seen as being less useful to society than other disciplines, notably in science, technology, engineering and mathematics. The paper explores how this assumption's construction has been built and whether it is based upon an unfair prejudice: we argue for a prima facie case…

  16. Microchemical and structural regular variability of apatites in 'overbuilt' enamel and dentin of human molar teeth

    Energy Technology Data Exchange (ETDEWEB)

    Kuczumow, A., E-mail: kuczon@kul.lublin.pl [Department of Chemistry, Lublin Catholic University, 20-718 Lublin (Poland); Nowak, J. [Department of Chemistry, Lublin Catholic University, 20-718 Lublin (Poland); ChaLas, R. [Department of Conservative Medicine, Lublin Medical University, 20-081 Lublin (Poland)

    2011-10-15

    The aim of a recent paper was to recognize the chemical and structural changes in apatites, which form both the enamel and the dentin of the human tooth. The aim was achieved by scrutinizing the linear elemental profiles along the cross-sections of human molar teeth. Essentially, the task was accomplished with the application of the Electron Probe Microanalysis method and with some additional studies by Micro-Raman spectrometry. All the trends in linear profiles were strictly determined. In the enamel zone they were either increasing or decreasing curves of exponential character. The direction of the investigations was to start with the tooth surface and move towards the dentin-enamel junction (DEJ). The results of the elemental studies were more visible when the detected material was divided, in an arbitrary way, into the prevailing 'core' enamel ({approx}93.5% of the total mass) and the remaining 'overbuilt' enamel. The material in the 'core' enamel was fully stable, with clearly determined chemical and mechanical features. However, the case was totally different in the 'overbuilt enamel', with dynamic changes in the composition. In the 'overbuilt' layer Ca, P, Cl and F profiles present the decaying distribution curves, whereas Mg, Na, K and CO{sub 3}{sup 2-} present the growing ones. Close to the surface of the tooth the mixture of hydroxy-, chlor- and fluor-apatite is formed, which is much more resistant than the rest of the enamel. On passing towards the DEJ, the apatite is enriched with Na, Mg and CO{sub 3}{sup 2-}. In this location, three of six phosphate groups were substituted with carbonate groups. Simultaneously, Mg is associated with the hydroxyl groups around the hexad axis. In this way, the mechanisms of exchange reactions were established. The crystallographic structures were proposed for new phases located close to DEJ. In the dentin zone, the variability of elemental profiles looks different, with

  17. Apolipoprotein A-IV constrains HPA and behavioral stress responsivity in a strain-dependent manner.

    Science.gov (United States)

    Packard, Amy E B; Zhang, Jintao; Myers, Brent; Ko, Chih-Wei; Wang, Fei; Tso, Patrick; Ulrich-Lai, Yvonne M

    2017-12-01

    There is a critical gap in our knowledge of the mechanisms that govern interactions between daily life experiences (e.g., stress) and metabolic diseases, despite evidence that stress can have profound effects on cardiometabolic health. Apolipoprotein A-IV (apoA-IV) is a protein found in chylomicrons (lipoprotein particles that transport lipids throughout the body) where it participates in lipid handling and the regulation of peripheral metabolism. Moreover, apoA-IV is expressed in brain regions that regulate energy balance including the arcuate nucleus. Given that both peripheral and central metabolic processes are important modulators of hypothalamic-pituitary-adrenocortical (HPA) axis activity, the present work tests the hypothesis that apoA-IV activity affects stress responses. As emerging data suggests that apoA-IV actions can vary with background strain, we also explore the strain-dependence of apoA-IV stress regulation. These studies assess HPA axis, metabolic (hyperglycemia), and anxiety-related behavioral responses to psychogenic stress in control (wildtype) and apoA-IV-deficient (KO) mice on either the C57Bl/6J (C57) or 129×1/SvJ (129) background strain. The results indicate that apoA-IV KO increases post-stress corticosterone and anxiety-related behavior specifically in the 129 strain, and increases stress-induced hyperglycemia exclusively in the C57 strain. These data support the hypothesis that apoA-IV is a novel factor that limits stress reactivity in a manner that depends on genetic background. An improved understanding of the complex relationship among lipid homeostasis, stress sensitivity, and genetics is needed to optimize the development of personalized treatments for stress- and metabolism-related diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Identification and quantification of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines in human urine as putative biomarkers of oxidatively induced damage to DNA

    Energy Technology Data Exchange (ETDEWEB)

    Jaruga, Pawel, E-mail: pawel.jaruga@nist.gov [Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Department of Clinical Biochemistry, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz (Poland); Dizdaroglu, Miral [Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States)

    2010-06-18

    Biomarkers of oxidatively induced DNA damage are of great interest and can potentially be used for the early detection of disease, monitoring the progression of disease and determining the efficacy of therapy. The present work deals with the measurement in human urine of (5'R)-8,5'-cyclo-2'-deoxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyadenosine (S-cdA). These modified nucleosides had hitherto not been considered or investigated to be present in urine as possible biomarkers of oxidatively induced DNA damage. Urine samples were collected from volunteers, purified and analyzed by LC-MS/MS with isotope-dilution. R-cdA and S-cdA were detected in urine and quantified. Creatinine levels were also measured. In addition, we measured 8-hydroxy-2'-deoxyguanosine that is commonly used as a biomarker. This study shows, for the first time, that R-cdA and S-cdA exist in human urine and can be identified and quantified by LC-MS/MS. We propose that R-cdA and S-cdA may be well-suited biomarkers for disease processes such as carcinogenesis.

  19. Circulating ApoJ is closely associated with insulin resistance in human subjects.

    Science.gov (United States)

    Seo, Ji A; Kang, Min-Cheol; Ciaraldi, Theodore P; Kim, Sang Soo; Park, Kyong Soo; Choe, Charles; Hwang, Won Min; Lim, Dong Mee; Farr, Olivia; Mantzoros, Christos; Henry, Robert R; Kim, Young-Bum

    2018-01-01

    Insulin resistance is a major risk factor for type 2 diabetes. ApolipoproteinJ (ApoJ) has been implicated in altered pathophysiologic states including cardiovascular and Alzheimer's disease. However, the function of ApoJ in regulation of glucose homeostasis remains unclear. This study sought to determine whether serum ApoJ levels are associated with insulin resistance in human subjects and if they change after interventions that improve insulin sensitivity. Serum ApoJ levels and insulin resistance status were assessed in nondiabetic (ND) and type 2 diabetic (T2D) subjects. The impacts of rosiglitazone or metformin therapy on serum ApoJ levels and glucose disposal rate (GDR) during a hyperinsulinemic/euglycemic clamp were evaluated in a separate cohort of T2D subjects. Total ApoJ protein or that associated with the HDL and LDL fractions was measured by immunoblotting or ELISA. Fasting serum ApoJ levels were greatly elevated in T2D subjects (ND vs T2D; 100±8.3 vs. 150.6±8.5AU, Pinsulin, HOMA-IR, and BMI. ApoJ levels were significantly and independently associated with HOMA-IR, even after adjustment for age, sex, and BMI. Rosiglitazone treatment in T2D subjects resulted in a reduction in serum ApoJ levels (before vs. after treatment; 100±13.9 vs. 77±15.2AU, P=0.015), whereas metformin had no effect on ApoJ levels. The change in ApoJ levels during treatment was inversely associated with the change in GDR. Interestingly, ApoJ content in the LDL fraction was inversely associated with HOMA-IR. Serum ApoJ levels are closely correlated with the magnitude of insulin resistance regardless of obesity, and decrease along with improvement of insulin resistance in response only to rosiglitazone in type 2 diabetes. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.

    Science.gov (United States)

    Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C

    2006-01-01

    Apolipoprotein (apo) A-IV is an anorexigenic gastrointestinal peptide that is also synthesized in the hypothalamus. The goal of these experiments was to determine whether apo A-IV interacts with the central melanocortin (MC) system in the control of feeding. The third ventricular (i3vt) administration of a subthreshold dose of apo A-IV (0.5 microg) potentiated i3vt MC-induced (metallothionein-II, 0.03 nmol) suppression of 30-min feeding in Long-Evans rats. A subthreshold dose of the MC antagonist (SHU9119, 0.1 nmol, i3vt) completely attenuated the anorectic effect of i3vt apo A-IV (1.5 microg). The i3vt apo A-IV significantly elevated the expression of c-Fos in neurons of the paraventricular nucleus of the hypothalamus, but not in the arcuate nucleus or median eminence. In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate.

  1. Total energy supply for remote human habitations (Or 'Nuclear North of 60')

    International Nuclear Information System (INIS)

    Harris, J.

    2012-01-01

    This presentation will examine the direct application of nuclear energy solutions in the north, and remote areas of Canada. Further it will challenge the existing energy network based on the shipment of fossil fuels to remote areas, and examine the use of small, modular, and/or deployable nuclear plants in these communities. The use of these small reactors and some newly emerging technologies will likely provide a near total energy supply for these communities. In particular low grade heat processes, district heating, the 'local' production of motive fuels, and local food production will be examined. Additionally the economic and social impact of moving the value added side of many of these processes to the local communities will also be briefly discussed.

  2. Analysis of Employee's Survey for Preventing Human-Errors

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Chanho; Kim, Younggab; Joung, Sanghoun [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    Human errors in nuclear power plant can cause large and small events or incidents. These events or incidents are one of main contributors of reactor trip and might threaten the safety of nuclear plants. To prevent human-errors, KHNP(nuclear power plants) introduced 'Human-error prevention techniques' and have applied the techniques to main parts such as plant operation, operation support, and maintenance and engineering. This paper proposes the methods to prevent and reduce human-errors in nuclear power plants through analyzing survey results which includes the utilization of the human-error prevention techniques and the employees' awareness of preventing human-errors. With regard to human-error prevention, this survey analysis presented the status of the human-error prevention techniques and the employees' awareness of preventing human-errors. Employees' understanding and utilization of the techniques was generally high and training level of employee and training effect on actual works were in good condition. Also, employees answered that the root causes of human-error were due to working environment including tight process, manpower shortage, and excessive mission rather than personal negligence or lack of personal knowledge. Consideration of working environment is certainly needed. At the present time, based on analyzing this survey, the best methods of preventing human-error are personal equipment, training/education substantiality, private mental health check before starting work, prohibit of multiple task performing, compliance with procedures, and enhancement of job site review. However, the most important and basic things for preventing human-error are interests of workers and organizational atmosphere such as communication between managers and workers, and communication between employees and bosses.

  3. Human apolipoprotein B (apoB) mRNA: Identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine

    International Nuclear Information System (INIS)

    Higuchi, K.; Hospattankar, A.V.; Law, S.W.; Meglin, N.; Cortright, J.; Brewer, H.B. Jr.

    1988-01-01

    Human apolipoprotein B (apoB) is present in plasma as two separate isoproteins, designated apoB-100 (512 kDa) and apoB-48 (250 kDa). ApoB is encoded by a single gene on chromosome 2, and a single nuclear mRNA is edited and processed into two separate apoB mRNAs. A 14.1-kilobase apoB mRNA codes for apoB-100, and the second mRNA, which codes for apoB-48, contains a premature stop codon generated by a single base substitution of cytosine to uracil at nucleotide 6,538, which converts the translated CAA codon coding for the amino acid glutamine at residue 2,153 in apoB-100 to a premature in-frame stop codon (UAA). Two 30-base synthetic oligonucleotides, designated apoB-Stop and apoB-Gln, were synthesized containing the complementary sequence to the stop codon (UAA) and glutamine codon (CAA), respectively. The combined results from these studies establish that both human intestine and liver contain the two distinct apoB mRNAs, an mRNA that codes for apoB-100 and an apoB mRNA that contains the premature stop codon, which codes for apoB-48. The premature in-frame stop codon is not tissue specific and is present in both human liver and intestine

  4. Energy tomorrow. Humanity's mover; Demain, l'energie. Moteur de l'humanite

    Energy Technology Data Exchange (ETDEWEB)

    Ngo, Ch

    2009-07-01

    How to satisfy the growing up energy demand? How to develop and make more accessible the renewable energies? Can we get rid of nuclear energy? What are the best options to avoid an energy crisis? How can we reduce our consumption and avoid wasting? In the beginning of this century, energy has become a major stake at the economic level as well as at the scientific and environmental ones. While humanity needs more energy, the available fossil fuel reserves are on the way of depletion. This pragmatic book presents the present day and future technological solutions to this problem and gives some precious energy-saving advices that anyone can implement every day. (J.S.)

  5. Human luteinized granulosa cells secrete apoB100-containing lipoproteins

    NARCIS (Netherlands)

    Gautier, Thomas; Becker, Steffi; Drouineaud, Veronique; Menetrier, Franck; Sagot, Paul; Nofer, Jerzy-Roch; von Otte, Soeren; Lagrost, Laurent; Masson, David; Tietge, Uwe J. F.

    Thus far, liver, intestine, heart, and placenta have been shown to secrete apolipoprotein (apo) B-containing lipoproteins. In the present study, we first investigated lipoproteins in human follicular fluid (FF), surrounding developing oocytes within the ovary, as well as in corresponding plasma

  6. Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans

    DEFF Research Database (Denmark)

    Bagdade, John; Pedersen, Bente K; Schwenke, Dawn

    2011-01-01

    B:E) apoB-containing subclasses present in VLDL. Therefore, we have directly measured these subclasses following their isolation by sequential immunoprecipitation in seven healthy male subjects during a 3-h infusion with recombinant human (rh) IL-6. Though plasma TG and apoB-containing particle number were...... unchanged by IL-6, the distribution of TG-rich subclasses was significantly altered. Compared to baseline values, LpB:E + LpB:C:E increased significantly at 0.5 h (p infused controls at 0.5 and 1 h (p

  7. Electromagnetic field effect simulation over a realistic pixel ed phantom human's brain

    Energy Technology Data Exchange (ETDEWEB)

    Rojas, R.; Calderon, J. A.; Rivera, T. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Calz. Legaria No. 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico); Azorin, J., E-mail: rafaelturing@prodigy.net.mx [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, 09340 Mexico D. F. (Mexico)

    2012-10-15

    The exposition to different types of electromagnetic radiations can produce damages and injures on the people's tissues. The scientist, spend time and resources studying the effects of electromagnetic fields over the organs. Particularly in medical areas, the specialist in imaging methodologies and radiological treatment, are very worried about no injure there patient. Determination of matter radiation interaction, can be experimental or theoretical is not an easy task anyway. At first case, is not possible make measures inside the patient, then the experimental procedure consist in make measures in human's dummy, however, is not possible see deformations of electromagnetic fields due the organs presence. In the second case, is necessary solve, the Maxwell's equations with the electromagnetic field, crossing a lot of organs and tissues with different electric and magnetic properties each one. One alternative for theoretical solution, is make a computational simulation, however, this option, require an enormous quantity of memory and large computational times. Then, the most simulations are making in 2 dimensional or in 3 dimensional although using human models approximations, build ed with basic geometrical figures, like spheres, cylinders, ellipsoids, etc. Obviously this models just lets obtain a coarse solution of the actually situation. In this work, we propose a novel methodology to build a realistic pixel ed phantom of human's organs, and solve the Maxwell's equations over this models, evidently, the solutions are more approximated to the real behaviour. Additionally, there models results optimized when they are discretized and the finite element method is used to calculate the electromagnetic field and the induced currents. (Author)

  8. Radioimmunodetection of human tumor xenografts by monoclonal antibody F(ab')/sub 2/ fragments

    Energy Technology Data Exchange (ETDEWEB)

    Herlyn, D.; Munz, D.L.; Herlyn, M.; Koprowski, H.; Powe, J.; Alavi, A.; Meinken, G.E.; Srivastava, S.C.

    1986-01-01

    Procedures are described for the radiolocalization of human tumors by murine monoclonal antibodies (MAb) in animal model systems. Visualization of tumor xenografts was clearer in nude mice compared to experimentally immunosuppressed mice due to the higher tumor viability. MAb localization in tumor tissue was greatly enhanced when F(ab')/sub 2/ fragments rather than intact antibody molecules were used. Although tumors could be visualized with /sup 131/I-, /sup 123/I-or /sup 111/In-labeled MAb fragments without background subtraction, tumor-to-background ratios of radioactivity were highest for /sup 131/I-labeled fragments. /sup 131/I-labeled F(ab')/sub 2/ fragments of eight MAb against human colorectal carcinoma, melanoma or lung carcinoma localized specifically only in those tumors that bound the MAb in vitro and not in unrelated tumors. Radiolabeled fragments of MAb with other specificities (anti-hepatitis virus MAb) did not localize in tumors. All MAb that inhibited tumor growth in nude mice effectively localized these tumors by ..gamma..-scintigraphy. Some MAb were effective in localizing tumors but ineffective in inhibiting their growth. The ability of the specific radiolabeled F(ab')/sub 2/ fragments to localize in tumor grafts correlated significantly with MAb binding affinity and density of antigenic sites on tumor cells together, but not with either in vitro binding parameter alone.

  9. Serum amyloid A is found on ApoB-containing lipoproteins in obese humans with diabetes.

    Science.gov (United States)

    Jahangiri, Anisa; Wilson, Patricia G; Hou, Tianfei; Brown, Aparna; King, Victoria L; Tannock, Lisa R

    2013-05-01

    In murine models of obesity/diabetes, there is an increase in plasma serum amyloid A (SAA) levels along with redistribution of SAA from high-density lipoprotein (HDL) to apolipoprotein B (apoB)-containing lipoprotein particles, namely, low-density lipoprotein and very low-density lipoprotein. The goal of this study was to determine if obesity is associated with similar SAA lipoprotein redistribution in humans. Three groups of obese individuals were recruited from a weight loss clinic: healthy obese (n = 14), metabolic syndrome (MetS) obese (n = 8), and obese with type 2 diabetes (n = 6). Plasma was separated into lipoprotein fractions by fast protein liquid chromatography, and SAA was measured in lipid fractions using enzyme-linked immunosorbent assay and Western blotting. Only the obese diabetic group had SAA detectable in apoB-containing lipoproteins, and SAA reverted back to HDL with active weight loss. In human subjects, SAA is found in apoB-containing lipoprotein particles only in obese subjects with type 2 diabetes, but not in healthy obese or obese subjects with MetS. Copyright © 2012 The Obesity Society.

  10. Identification of the human ApoAV gene as a novel RORα target gene

    International Nuclear Information System (INIS)

    Lind, Ulrika; Nilsson, Tina; McPheat, Jane; Stroemstedt, Per-Erik; Bamberg, Krister; Balendran, Clare; Kang, Daiwu

    2005-01-01

    Retinoic acid receptor-related orphan receptor-α (RORα) (NR1F1) is an orphan nuclear receptor with a potential role in metabolism. Previous studies have shown that RORα regulates transcription of the murine Apolipoprotein AI gene and human Apolipoprotein CIII genes. In the present study, we present evidence that RORα also induces transcription of the human Apolipoprotein AV gene, a recently identified apolipoprotein associated with triglyceride levels. Adenovirus-mediated overexpression of RORα increased the endogenous expression of ApoAV in HepG2 cells and RORα also enhanced the activity of an ApoAV promoter construct in transiently transfected HepG2 cells. Deletion and mutation studies identified three AGGTCA motifs in the ApoAV promoter that mediate RORα transactivation, one of which overlaps with a previously identified binding site for PPARα. Together, these results suggest a novel mechanism whereby RORα modulates lipid metabolism and implies RORα as a potential target for the treatment of dyslipidemia and atherosclerosis

  11. Identification of the human ApoAV gene as a novel ROR{alpha} target gene

    Energy Technology Data Exchange (ETDEWEB)

    Lind, Ulrika [Department of Molecular Pharmacology, AstraZeneca R and D Moelndal (Sweden); Nilsson, Tina [Department of Molecular Pharmacology, AstraZeneca R and D Moelndal (Sweden); McPheat, Jane [Department of Molecular Pharmacology, AstraZeneca R and D Moelndal (Sweden); Stroemstedt, Per-Erik [Department of Molecular Pharmacology, AstraZeneca R and D Moelndal (Sweden); Bamberg, Krister [Department of Molecular Pharmacology, AstraZeneca R and D Moelndal (Sweden); Balendran, Clare [Department of Molecular Pharmacology, AstraZeneca R and D Moelndal (Sweden); Kang, Daiwu [Department of Molecular Pharmacology, AstraZeneca R and D Moelndal (Sweden)

    2005-04-29

    Retinoic acid receptor-related orphan receptor-{alpha} (ROR{alpha}) (NR1F1) is an orphan nuclear receptor with a potential role in metabolism. Previous studies have shown that ROR{alpha} regulates transcription of the murine Apolipoprotein AI gene and human Apolipoprotein CIII genes. In the present study, we present evidence that ROR{alpha} also induces transcription of the human Apolipoprotein AV gene, a recently identified apolipoprotein associated with triglyceride levels. Adenovirus-mediated overexpression of ROR{alpha} increased the endogenous expression of ApoAV in HepG2 cells and ROR{alpha} also enhanced the activity of an ApoAV promoter construct in transiently transfected HepG2 cells. Deletion and mutation studies identified three AGGTCA motifs in the ApoAV promoter that mediate ROR{alpha} transactivation, one of which overlaps with a previously identified binding site for PPAR{alpha}. Together, these results suggest a novel mechanism whereby ROR{alpha} modulates lipid metabolism and implies ROR{alpha} as a potential target for the treatment of dyslipidemia and atherosclerosis.

  12. How Can We Assess and Evaluate the Competitive Advantage of a Country's Human Resource Development System?

    Science.gov (United States)

    Oh, Hunseok; Ryu, Hyue-Hyun; Choi, Myungweon

    2013-01-01

    The purpose of this study was to develop an index to assess and evaluate the competitive advantage of a country's human resource development system. Based on an extensive literature review, a theoretical model of a human resource development system at the national level (named National Human Resource Development: NHRD) was constructed. The…

  13. The Relationship between Human Operators' Psycho-physiological Condition and Human Errors in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Arryum; Jang, Inseok; Kang, Hyungook; Seong, Poonghyun [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2013-05-15

    The safe operation of nuclear power plants (NPPs) is substantially dependent on the performance of the human operators who operate the systems. In this environment, human errors caused by inappropriate performance of operator have been considered to be critical since it may lead serious problems in the safety-critical plants. In order to provide meaningful insights to prevent human errors and enhance the human performance, operators' physiological conditions such as stress and workload have been investigated. Physiological measurements were considered as reliable tools to assess the stress and workload. T. Q. Tran et al. and J. B. Brooking et al pointed out that operators' workload can be assessed using eye tracking, galvanic skin response, electroencephalograms (EEGs), heart rate, respiration and other measurements. The purpose of this study is to investigate the effect of the human operators' tense level and knowledge level to the number of human errors. For this study, the experiments were conducted in the mimic of the main control rooms (MCR) in NPP. It utilized the compact nuclear simulator (CNS) which is modeled based on the three loop Pressurized Water Reactor, 993MWe, Kori unit 3 and 4 in Korea and the subjects were asked to follow the tasks described in the emergency operating procedures (EOP). During the simulation, three kinds of physiological measurement were utilized; Electrocardiogram (ECG), EEG and nose temperature. Also, subjects were divided into three groups based on their knowledge of the plant operation. The result shows that subjects who are tense make fewer errors. In addition, subjects who are in higher knowledge level tend to be tense and make fewer errors. For the ECG data, subjects who make fewer human errors tend to be located in higher tense level area of high SNS activity and low PSNS activity. The results of EEG data are also similar to ECG result. Beta power ratio of subjects who make fewer errors was higher. Since beta

  14. Drinking water pollution and risks for human health; Inquinamento dell'acqua potabile e rischi per la salute

    Energy Technology Data Exchange (ETDEWEB)

    Bressa, G. [Padua Univ., Padua (Italy). Dipt. di Farmacologia, Laboratorio di Tossicologia

    1999-12-01

    The hypothesis that most human tumors are caused by toxic substances found in the environment, and that their onset is therefore basically predictable, is earning wider and wider consent. The results of experimental studies carried out on animals have shown that some of the chemical pollutants found in drinking water possess cancerogenous activity. Their origin and can vary a lot because most public water supplies come from rivers, lakes, or from groundwater tables, and, therefore, contain pollutants from agricultural land waste water, from industrial waste and from deliberate or accidental inputs. As a consequence, this kind of pollution can involve some risks for human health as a result of both direct use of tainted water or indirect use through food. [Italian] Trova sempre piu' consenso l'ipotesi secondo cui la maggior parte dei tumori nell'uomo sia prodotta da sostanze tossiche presenti nell'ambiente e che quindi la loro insorgenza sia fondamentalmente prevenibile. Dalla vasta gamma di contaminati chimici identificabli nell'acqua potabile e' risultato, da studi sperimentali su animali, che alcuni possiedono attivita' cancerogena. Essi possono avere provenienze diverse, in quanto la maggior parte dei rifornimenti idrici pubblici originano da fiumi, laghi o dalla falda freatica, portando con se' inquinanti provenienti dalle acque reflue dei terreni agricoli, da rifiuti industriali e da immissioni deliberate o accidentali. Tale inquinamento di conseguenza puo' comportare dei rischi per la salute umana sia in seguito al consumo diretto di acqua contaminata che indirettamente attraverso gli alimenti.

  15. 'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

    Energy Technology Data Exchange (ETDEWEB)

    Jetten, Marlon J.A.; Gaj, Stan [Department of Toxicogenomics, Maastricht University, Universitiessingel 50 6229 ER Maastricht (Netherlands); Ruiz-Aracama, Ainhoa [RIKILT, Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE, Wageningen (Netherlands); Kok, Theo M. de [Department of Toxicogenomics, Maastricht University, Universitiessingel 50 6229 ER Maastricht (Netherlands); Delft, Joost H.M. van, E-mail: j.vandelft@maastrichtuniversity.nl [Department of Toxicogenomics, Maastricht University, Universitiessingel 50 6229 ER Maastricht (Netherlands); Lommen, Arjen [RIKILT, Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE, Wageningen (Netherlands); Someren, Eugene P. van [Research Group Microbiology and Systems Biology, TNO, PO Box 360 3700 AJ Zeist (Netherlands); Jennen, Danyel G.J.; Claessen, Sandra M. [Department of Toxicogenomics, Maastricht University, Universitiessingel 50 6229 ER Maastricht (Netherlands); Peijnenburg, Ad A.C.M. [RIKILT, Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE, Wageningen (Netherlands); Stierum, Rob H. [Research Group Microbiology and Systems Biology, TNO, PO Box 360 3700 AJ Zeist (Netherlands); Kleinjans, Jos C.S. [Department of Toxicogenomics, Maastricht University, Universitiessingel 50 6229 ER Maastricht (Netherlands)

    2012-03-15

    Acetaminophen is the primary cause of acute liver toxicity in Europe/USA, which led the FDA to reconsider recommendations concerning safe acetaminophen dosage/use. Unfortunately, the current tests for liver toxicity are no ideal predictive markers for liver injury, i.e. they only measure acetaminophen exposure after profound liver toxicity has already occurred. Furthermore, these tests do not provide mechanistic information. Here, 'omics techniques (global analysis of metabolomic/gene-expression responses) may provide additional insight. To better understand acetaminophen-induced responses at low doses, we evaluated the effects of (sub-)therapeutic acetaminophen doses on metabolite formation and global gene-expression changes (including, for the first time, full-genome human miRNA expression changes) in blood/urine samples from healthy human volunteers. Many known and several new acetaminophen-metabolites were detected, in particular in relation to hepatotoxicity-linked, oxidative metabolism of acetaminophen. Transcriptomic changes indicated immune-modulating effects (2 g dose) and oxidative stress responses (4 g dose). For the first time, effects of acetaminophen on full-genome human miRNA expression have been considered and confirmed the findings on mRNA level. 'Omics techniques outperformed clinical chemistry tests and revealed novel response pathways to acetaminophen in humans. Although no definitive conclusion about potential immunotoxic effects of acetaminophen can be drawn from this study, there are clear indications that the immune system is triggered even after intake of low doses of acetaminophen. Also, oxidative stress-related gene responses, similar to those seen after high dose acetaminophen exposure, suggest the occurrence of possible pre-toxic effects of therapeutic acetaminophen doses. Possibly, these effects are related to dose-dependent increases in levels of hepatotoxicity-related metabolites. -- Highlights: ► 'Omics techniques

  16. Teachers as Human Capital or Human Beings? USAID's Perspective on Teachers

    Science.gov (United States)

    Ginsburg, Mark

    2017-01-01

    This article analyzes three USAID education strategy documents (1998, 2005, and 2011) as well as USAID's requests for proposals for three projects to assess how teachers are represented. The main findings indicate that USAID education strategy documents a) treat teachers as human capital, a human resource input, rather than as human beings and b)…

  17. Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase

    NARCIS (Netherlands)

    Hendriks, W.L.; Sman van der - Beer, F. de; Vlijmen, B.J.M. van; Vark, L.C. van; Hofker, M.H.; Havekes, L.M.

    1997-01-01

    Apolipoprotein (apo) E-deficient mice display marked accumulation in the plasma of VLDL deficient in both apoE and apoBl00 but containing apoB48, apoA-1, apoCs, and apoA-IV. Since apoE-deficient mice develop severe atherosclerotic lesions with lipid-laden macrophages, we reasoned that the uptake of

  18. Replication Banding Patterns in Human Chromosomes Detected Using 5-ethynyl-2'-deoxyuridine Incorporation

    International Nuclear Information System (INIS)

    Hoshi, Osamu; Ushiki, Tatsuo

    2011-01-01

    A novel technique using the incorporation of 5-ethynyl-2'-deoxyuridine (EdU) into replicating DNA is described for the analysis of replicating banding patterns of human metaphase chromosomes. Human lymphocytes were synchronized with excess thymidine and treated with EdU during the late S phase of the cell cycle. The incorporated EdU was then detected in metaphase chromosomes using Alexa Fluor® 488 azides, through the 1,3-dipolar cycloaddition reaction of organic azides with the terminal acetylene group of EdU. Chromosomes with incorporated EdU showed a banding pattern similar to G-banding of normal human chromosomes. Imaging by atomic force microscopy (AFM) in liquid conditions showed that the structure of the chromosomes was well preserved even after EdU treatment. Comparison between fluorescence microscopy and AFM images of the same chromosome 1 indicated the presence of ridges and grooves in the chromatid arm, features that have been previously reported in relation to G-banding. These results suggest an intimate relationship between EdU-induced replication bands and G- or R-bands in human chromosomes. This technique is thus useful for analyzing the structure of chromosomes in relation to their banding patterns following DNA replication in the S phase

  19. Contributions to a Marxist Critical Pedagogy: Revisiting Marx's Humanism

    Science.gov (United States)

    Malott, Curry

    2014-01-01

    In this essay Malott makes a case for a Marxist-informed critical pedagogy situating Marx's approach to Hegelian dialectics at the center. After reviewing Marx's critique of Hegel in his 1844 manuscripts, Malott outlines Marx's shifting conception of the falling rate of profit reflecting his developing understanding of what the…

  20. The influence of chronic stress on anxiety-like behavior and cognitive function in different human GFAP-ApoE transgenic adult male mice.

    Science.gov (United States)

    Meng, Fan-Tao; Zhao, Jun; Fang, Hui; Liu, Ya-Jing

    2015-01-01

    The apolipoprotein E (ApoE) ɛ4 allele (ApoE4) is an important genetic risk factor for the pathogenesis of Alzheimer's disease (AD). In addition to genetic factors, environmental factors such as stress may play a critical role in AD pathogenesis. This study was designed to investigate the anxiety-like behavioral and cognitive changes in different human glial fibrillary acidic protein (GFAP)-ApoE transgenic adult male mice under chronic stress conditions. On the open field test, anxiety-like behavior was increased in the non-stressed GFAP-ApoE4 transgenic mice relative to the corresponding GFAP-ApoE3 (ApoE ɛ3 allele) mice. Anxiety-like behavior was increased in the stressed GFAP-ApoE3 mice relative to non-stressed GFAP-ApoE3 mice, but was unexpectedly decreased in the stressed GFAP-ApoE4 mice relative to non-stressed GFAP-ApoE4 mice. On the novel object recognition task, both GFAP-ApoE4 and GFAP-ApoE3 mice exhibited long-term non-spatial memory impairment after chronic stress. Interestingly, short-term non-spatial memory impairment (based on the novel object recognition task) was observed only in the stressed GFAP-ApoE4 male mice relative to non-stressed GFAP-ApoE4 transgenic mice. In addition, short-term spatial memory impairment was observed in the stressed GFAP-ApoE3 transgenic male mice relative to non-stressed GFAP-ApoE3 transgenic male mice; however, short-term spatial memory performance of GFAP-ApoE4 transgenic male mice was not reduced compared to non-stressed control mice based on the Y-maze task. In conclusion, our findings suggested that chronic stress affects anxiety-like behavior and spatial and non-spatial memory in GFAP-ApoE transgenic mice in an ApoE isoform-dependent manner.

  1. Calibration Human Voxel Phantoms for In Vivo Measurement of ''241 Am in Bone at the Whole Body Counter Facility of CIEMAT

    Energy Technology Data Exchange (ETDEWEB)

    Moraleda, M.; Lopez, M. A.; Gomez Ros, J. M.; Navarro, T.; Navarro, J. F.

    2002-07-01

    The Whole Body Counting facility of CIEMAT is capable of carrying out In-Vivo measurements of radionuclides emitting X-rays and low energy gamma radiation internally deposited in the body. The system to use for this purpose consists of flour Low energy Germanium (LeGe) Camberra detectors working in the energy range from 10 to 1000 keV. Physical phantoms with a known contamination in the organ of interest are normally used for the calibration of the LEGe detection system. In this document we present a calibration method using the Monte Carlo technique (MCNP4C) over a voxel phantom obtained from a computerized tomography of a real human head. The phantom consists of 104017 (43x59x41) cubic voxels, 4 mn on each side, os specific tissues, but for this simulation only two types are taken into account: adipose tissue and hard bone. The skull is supposed to be contaminated with ''241 Am and the trajectories of the photons are simulated till they reach the germanium detectors. The detectors were also simulated in detail to obtain a good agreement with the reality. In order to verify the accuracy of this procedure to reproduce the experiments, the MCNP results are compared with laboratory measurements of a head phantom simulating an internal contamination of 1000 Bq of ''241 Am deposited in bone. Different relative positions source-detector were tried to look for the best countring geometry for measurement of a contaminated skull. Efficiency values are obtained and compared, resulting in the validation of the mathematical method for the assessment of internal contamination of American deposited in skeleton. (Author) 16 refs.

  2. Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

    NARCIS (Netherlands)

    Berbée, J.F.P.; Hoogt, C.C. van der; Sundararaman, D.; Havekes, L.M.; Rensen, P.C.N.

    2005-01-01

    Studies in humans and mice have shown that increased expression of apolipoprotein C-I (apoC-I) results in combined hyperlipidemia with a more pronounced effect on triglycerides (TGs) compared with total cholesterol (TC). The aim of this study was to elucidate the main reason for this effect using

  3. The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.

    Directory of Open Access Journals (Sweden)

    Alvina W M To

    2011-02-01

    Full Text Available Impaired insulin signalling is increasingly thought to contribute to Alzheimer's disease (AD. The ε4 isoform of the APOE gene is the greatest genetic risk factor for sporadic, late onset AD, and is also associated with risk for type 2 diabetes mellitus (T2DM. Neuropathological studies reported the highest number of AD lesions in brain tissue of ε4 diabetic patients. However other studies assessing AD pathology amongst the diabetic population have produced conflicting reports and have failed to show an increase in AD-related pathology in diabetic brain. The thiazolidinediones (TZDs, peroxisome proliferator-activated receptor gamma agonists, are peripheral insulin sensitisers used to treat T2DM. The TZD, pioglitazone, improved memory and cognitive functions in mild to moderate AD patients. Since it is not yet clear how apoE isoforms influence the development of T2DM and its progression to AD, we investigated amyloid beta and tau pathology in APOE knockout mice, carrying human APOEε3 or ε4 transgenes after diet-induced insulin resistance with and without pioglitazone treatment.Male APOE knockout, APOEε3-transgenic and APOEε4-transgenic mice, together with background strain C57BL6 mice were kept on a high fat diet (HFD or low fat diet (LFD for 32 weeks, or were all fed HFD for 32 weeks and during the final 3 weeks animals were treated with pioglitazone or vehicle.All HFD animals developed hyperglycaemia with elevated plasma insulin. Tau phosphorylation was reduced at 3 epitopes (Ser396, Ser202/Thr205 and Thr231 in all HFD, compared to LFD, animals independent of APOE genotype. The introduction of pioglitazone to HFD animals led to a significant reduction in tau phosphorylation at the Ser202/Thr205 epitope in APOEε3 animals only. We found no changes in APP processing however the levels of soluble amyloid beta 40 was reduced in APOE knockout animals treated with pioglitazone.

  4. Proceedings of the workshop on 'effect of radiation on non-human biota'

    International Nuclear Information System (INIS)

    Takahashi, Sentaro; Takahashi, Tomoyuki

    2011-03-01

    Safety assessment and protection for the radiation exposure were so far mainly based on the radiation effects on human health, because it has been generally recognized that, when human beings are protected, other environmental life, at least in the level of species or groups, will be protected from the radiation hazards, even if individuals may be affected. Recently, with increasing concern on environmental protection, a new framework of radiation protection has been proposed, where non-human biota as well as human beings is included. Researches on the environmental radiation protection need a contribution of multi-disciplinary researchers as similar to the other environmental sciences. Especially, a research field on the biological effect of radiation on non-human biota is fundamental and essential. Therefore, we planned the Workshop entitled Effect of Radiation on the Non-human Biota this time. All the 13 papers presented at the entitled meeting are indexed individually. (J.P.N.)

  5. A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine

    Energy Technology Data Exchange (ETDEWEB)

    Morin, Kevin W. [Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, T6G 2N8 (Canada); Duan Weili [Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, T6G 2N8 (Canada); Knaus, Edward E. [Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, T6G 2N8 (Canada); McEwan, Alexander J.B. [Department of Radiology and Diagnostic Imaging, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G 2N8 (Canada); Wiebe, Leonard I. [Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, T6G 2N8 (Canada)]. E-mail: leonard.wiebe@ualberta.ca

    2005-07-01

    Introduction: (E)-5-(2-Iodovinyl)-2'-fluoro-2'-deoxyuridine (IVFRU) is a pyrimidine nucleoside analogue that accumulates selectively in murine cells expressing herpes simplex type-1 thymidine kinase (HSV-1 TK). The uptake of [{sup 125}I]IVFRU in human 143B osteosarcoma cells transduced with a retroviral vector bearing the HSV-1 TK gene (143B-LTK cells) is now reported. Methods: HSV-1 TK gene expression in 143B-LTK cells was confirmed by Western blotting and reverse transcriptase (RT)-PCR. Cell and subcellular uptake of [{sup 125}I]IVFRU was determined in cell culture, and whole body biodistribution after intravenous injection of [{sup 125}I]IVFRU was determined using nude mice bearing implanted 143B or 143B-LTK tumors. Results: Although IVFRU was less toxic to the human cell line expressing HSV-1 TK (143B-LTK) than ganciclovir, both IVFRU and ganciclovir were not toxic to the cell line not expressing HSV-1 TK (143B). When cells were exposed to [{sup 125}I]IVFRU in vitro, only the 143B-LTK cells accumulated radioactivity. The acid-soluble fraction from 143B-LTK cell lysates contained 8-fold greater activity than the acid-insoluble fraction after an 8-h exposure to [{sup 125}I]IVFRU. Biodistribution of [{sup 125}I]IVFRU in nude mice bearing subcutaneous 143B and 143B-LTK tumors revealed widespread distribution of the nucleoside in vivo but with specific localization in 143B-LTK tumors. Conclusion: The underlying biochemical process of metabolic entrapment of IVFRU in human osteosarcoma cells expressing HSV-1 TK is responsible for selective localization in these cells. The differences in subcellular distribution into the nucleic acid fraction, and in cytotoxicity, reflect the importance of cell type and lineage as determinants of the performance of gene imaging radiopharmaceuticals.

  6. How to save the earth planet. Ecology and human spirit. Sauver la planete terre. L'ecologie et l'esprit humain

    Energy Technology Data Exchange (ETDEWEB)

    Al Gore.

    1993-01-01

    The author has undertaken for 25 years in all the struggles for the environment protection. His ecology competences are worldwide recognized. With ''HOW TO SAVE THE EARTH PLANET'' AL GORE calls for help facing a great importance economic crisis, the consequences of which are dramatic. Beyond the exhaustive report, very well documented on the scientific topics, he proposes a true ecologic ''Marshall PLAN'' at the planet level, and a global reflection followed by precise and concrete measures. In the beginning of the XXIst century the challenge taken up by AL GORE is also a true defence plea for the future. We are all concerned and our children too. 27 refs.

  7. Cultured human astrocytes secrete large cholesteryl ester- andtriglyceride-rich lipoproteins along with endothelial lipase

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Lin; Liu, Yanzhu; Forte, Trudy M.; Chisholm, Jeffrey W.; Parks, John S.; Shachter, Neil S.

    2003-12-01

    We cultured normal human astrocytes and characterized their secreted lipoproteins. Human astrocytes secreted lipoproteins in the size range of plasma VLDL (Peak 1), LDL (Peak 2), HDL (Peak 3) and a smaller peak (Peak 4), as determined by gel filtration chromatography, nondenaturing gradient gel electrophoresis and transmission electron microscopy. Cholesterol enrichment of astrocytes led to a particular increase in Peak 1. Almost all Peak 2, 3 and 4 cholesterol and most Peak 1 cholesterol was esterified (unlike mouse astrocyte lipoproteins, which exhibited similar peaks but where cholesterol was predominantly non-esterified). Triglycerides were present at about 2/3 the level of cholesterol. LCAT was detected along with two of its activators, apolipoprotein (apo) A-IV and apoC-I. ApoA-I and apoA-II mRNA and protein were absent. ApoJ was present equally in all peaks but apoE was present predominantly in peaks 3 and 4. ApoB was not detected. The electron microscopic appearance of Peak 1 lipoproteins suggested partial lipolysis leading to the detection of a heparin-releasable triglyceride lipase consistent with endothelial lipase. The increased neuronal delivery of lipids from large lipoprotein particles, for which apoE4 has greater affinity than does apoE3, may be a mechanism whereby the apoE {var_epsilon}4 allele contributes to neurodegenerative risk.

  8. The insecticide lindane. Identification of possible risks for human reproduction; L'insetticida lindano. Identificazione dei rischi possibili per la riproduzione umana

    Energy Technology Data Exchange (ETDEWEB)

    Traina, M.E.; Urbani, E. [Istituto Superiore di Sanita' , Lab. di Igiene Ambientale, Rome (Italy); Rescia, M.; Mantovani, A. [Istituto Superiore di Sanita' , Lab. di Tossicologia Comparata e Ecotossicologia, Rome (Italy)

    2001-07-01

    A growing international concern exists about the potential harm to human reproduction caused by pollutants able to interfere with the endocrine system. Particular interest is addressed to organochlorine pesticides persisting in the environment and organisms; such compounds are extensively studied for their adverse effects on reproductive functions and development of laboratory animals. The insecticide lindane (the {gamma}-isomer of hexachlorocyclohexane), widely used before the 80s, has yet to be adequately evaluated as regards the possible reproductive risk. The present report contains a critical revision of the available scientific literature about lindane effects on the male and female reproductive system, pregnancy and development. Besides, the possible higher exposure periods to this pesticide (years 60s-70s) have been determined through the analysis of the lindane products consumed and the evaluation of the active ingredient levels in the environment and in the tissues and biological fluids, with particular regard to Italy. The present review aims at supporting further toxicological and epidemiological studies to assess the possible reproductive risk posed by environmental and professional exposure to chlorinated insecticides. [Italian] L'ipotesi che l'esposizione a sostanze inquinanti in grado di alterare l'equilibrio del sistema endocrino possa avere effetti sulla riproduzione umana e sullo sviluppo e' attualmente oggetto d'interesse nella comunita' scientifica. Particoalre attenzione e' stata indirizzata ai pesticidi organoclorurati a lunga persistenza nell'ambiente e negli organismi, per i quali esistono numerose evidenze di effetti nocivi per la riproduzione, negli studi di tossicologia sperimentale. L'insetticida lindano (l'isomero-{gamma} dell'esaclorocicloesano), largamente utilizzato prima degli anni '80, non e' stato fino ad oggi adeguatamente valutato per un possibile rischio

  9. Sequence, 'subtle' alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors

    International Nuclear Information System (INIS)

    Vitale, Lorenza; Coppola, Domenico; Strippoli, Pierluigi; Frabetti, Flavia; Huntsman, Shane A; Canaider, Silvia; Casadei, Raffaella; Lenzi, Luca; Facchin, Federica; Carinci, Paolo; Zannotti, Maria

    2007-01-01

    CYYR1 is a recently identified gene located on human chromosome 21 whose product has no similarity to any known protein and is of unknown function. Analysis of expressed sequence tags (ESTs) have revealed high human CYYR1 expression in cells belonging to the diffuse neuroendocrine system (DNES). These cells may be the origin of neuroendocrine (NE) tumors. The aim of this study was to conduct an initial analysis of sequence, splicing and expression of the CYYR1 mRNA in human NE tumors. The CYYR1 mRNA coding sequence (CDS) was studied in 32 NE tumors by RT-PCR and sequence analysis. A subtle alternative splicing was identified generating two isoforms of CYYR1 mRNA differing in terms of the absence (CAG - isoform, the first described mRNA for CYYR1 locus) or the presence (CAG + isoform) of a CAG codon. When present, this specific codon determines the presence of an alanine residue, at the exon 3/exon 4 junction of the CYYR1 mRNA. The two mRNA isoform amounts were determined by quantitative relative RT-PCR in 29 NE tumors, 2 non-neuroendocrine tumors and 10 normal tissues. A bioinformatic analysis was performed to search for the existence of the two CYYR1 isoforms in other species. The CYYR1 CDS did not show differences compared to the reference sequence in any of the samples, with the exception of an NE tumor arising in the neck region. Sequence analysis of this tumor identified a change in the CDS 333 position (T instead of C), leading to the amino acid mutation P111S. NE tumor samples showed no significant difference in either CYYR1 CAG - or CAG + isoform expression compared to control tissues. CYYR1 CAG - isoform was significantly more expressed than CAG + isoform in NE tumors as well as in control samples investigated. Bioinformatic analysis revealed that only the genomic sequence of Pan troglodytes CYYR1 is consistent with the possible existence of the two described mRNA isoforms. A new 'subtle' splicing isoform (CAG + ) of CYYR1 mRNA, the sequence and

  10. Apolipoprotein A-IV concentrations and clinical outcomes in haemodialysis patients with type 2 diabetes mellitus--a post hoc analysis of the 4D Study.

    Science.gov (United States)

    Kollerits, B; Krane, V; Drechsler, C; Lamina, C; März, W; Ritz, E; Wanner, C; Kronenberg, F

    2012-12-01

    Apolipoprotein A-IV (apoA-IV) is an anti-atherogenic and anti-oxidative plasma glycoprotein involved in reverse cholesterol transport. The aim of this study was to examine the association between apoA-IV and all-cause mortality, cardiovascular endpoints and parameters of protein-energy wasting and nutrition in haemodialysis patients. This post hoc analysis was performed in the German Diabetes Dialysis Study (4D Study) evaluating atorvastatin in 1255 haemodialysis patients with type 2 diabetes mellitus, followed for a median of 4 years. The association between apoA-IV and relevant outcomes was analysed using Cox proportional hazards regression analyses. Body mass index (BMI) was used as a marker of protein-energy wasting. In addition, a definition of extended wasting was applied, combining median values of BMI, serum albumin, creatinine and sensitive C-reactive protein, to classify patients. Mean (±SD) apoA-IV concentration was 49.8 ± 14.2 mg dL(-1). Age- and gender-adjusted apoA-IV concentrations were strongly associated with the presence of congestive heart failure at baseline [odds ratio = 0.81, 95% confidence interval (CI) 0.74-0.88 per 10 mg dL(-1) increase; P 1). During the prospective follow-up, the strongest association was found for all-cause mortality [hazard ratio (HR) = 0.89, 95% CI 0.85-0.95, P = 0.001), which was mainly because of patients with BMI > 23 kg m(-2) (HR = 0.87, 95% CI 0.82-0.94, P 1) and those in the nonwasting group according to the extended definition (HR = 0.89, 95% CI 0.84-0.96, P = 0.001). This association remained significant after additionally adjusting for parameters associated with apoA-IV at baseline. Further associations were observed for sudden cardiac death. ApoA-IV was less strongly associated with atherogenic events such as myocardial infarction. Low apoA-IV levels seem to be a risk predictor of all-cause mortality and sudden cardiac death. This association might be modified by nutritional status. © 2012 The Association

  11. As Luck Would Have It: Thomas Hardy's "Bildungsroman" on Leading a Human Life

    Science.gov (United States)

    Laverty, Megan Jane

    2014-01-01

    In this essay, I demonstrate the value of the Bildungsroman for philosophy of education on the grounds that these narratives raise and explore educational questions. I focus on a short story in the Bildungsroman tradition, Thomas Hardy's "A Mere Interlude". This story describes the maturation of its heroine by narrating a series of…

  12. Science and the Humanities: Stephen Jay Gould's Quest to Join the High Table

    Science.gov (United States)

    Ruse, Michael

    2013-01-01

    Stephen Jay Gould was a scientist, a paleobiologist, who was also a professional-level historian of science. This essay explores Gould's work, showing how he used the history of science to further his agenda as a working scientist.

  13. A new Job's tear cultivar ''Hatohikari''

    International Nuclear Information System (INIS)

    Ishida, M.; Chiba, I.; Kato, M.; Okuyama, Y.; Sugawara, S.; Tanosaki, S.; Shindo, K.; Ishikura, N.; Seki, K.; Endo, T.; Shibata, M.

    1997-01-01

    A new Job's tear cultivar ''Hatohikari'', developed at the Tohoku National Agricultural Experiment Station, Morioka, Japan was registered as Norin No.2 Job's tear and released by Japan's Ministry of Agriculture, Forestry and Fisheries in 1995. ''Hatohikari'' is a progeny from a gamma-ray radiated mutant of ''Okayama-zairai'' in 1980. ''Okayama-zairai'' shows high yield and good quality. However, its demerits are late maturity and long plant height. The major agronomic characteristics of the new cultivar ''Hatohikari'' are as follows: The maturity is earlier than that of ''Okayama0zairai'', yielding ability is 38% higher than that of ''Okayama-zairai , the plant height is 30 cm shorter than that of ''Okayama-zairai'' and it is suitable for combine harvest. ''Hatohikari'' has large seeds with good quality for tea processing. Shattering is easy, and resistance to leaf blight is medium. ''Hatohikari'' is adaptable to middle mountain regions in chugoku district of Japan. This cultivar has been recommended in Hiroshima prefecture since 1995

  14. Proceedings of the Topical Session of the 9. Meeting of the WPDD on 'Human and Organisational Factors in Decommissioning' Held at Harwell, United Kingdom on 7-8 November 2007

    International Nuclear Information System (INIS)

    NOYNAERT, Luc; O'SULLIVAN, Patrick

    2008-01-01

    At its eight meeting, the WPDD held a topical session on 'Human and Organisational Factors in Decommissioning'. This report documents the topical session. The main text summarises the main points from the presentations and discussions and includes the Rapporteur's report. Appendix 1 and 2 provide the agenda of the topical session and the list of attendees respectively. The topical session facilitated an exchange of information and experience on the following issues in particular: - Project management and contracting schemes being used for decommissioning projects and the benefits which may be gained from including former operational staff in decommissioning teams; - Planning and record keeping, including the extent to which inadequate historical records need be reconstructed; and - Approaches to workforce management, particularly in regard to safety. At the end of each session time was allotted for a plenary discussion. The Rapporteur reviewed the main points and the lessons learnt at the end of the Topical Session

  15. Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response

    International Nuclear Information System (INIS)

    Yan, Ying; Gao, Yan-Yan; Liu, Bao-Qin; Niu, Xiao-Fang; Zhuang, Ying; Wang, Hua-Qin

    2010-01-01

    Resveratrol (RES), a natural phytoalexin found at high levels in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. However, the underlying molecular mechanisms are at present only partially understood. The effects of RES on activation of unfolded protein responses (UPR) were evaluated using Western blotting, semi-quantitative and real-time RT-PCR. Cell death was evaluated using Annexin V/PI staining and subsequent FACS. Similar as tunicamycin, treatment with RES lead to the activation of all 3 branches of the UPR, with early splicing of XBP-1 indicative of IRE1 activation, phosphorylation of eIF2α consistent with ER resident kinase (PERK) activation, activating transcription factor 6 (ATF6) splicing, and increase in expression levels of the downstream molecules GRP78/BiP, GRP94 and CHOP/GADD153 in human Burkitt's lymphoma Raji and Daudi cell lines. RES was shown to induce cell death, which could be attenuated by thwarting upregulation of CHOP. Our data suggest that activation of the apoptotic arm of the UPR and its downstream effector CHOP/GADD153 is involved, at least in part, in RES-induced apoptosis in Burkitt's lymphoma cells

  16. Evaluation of Human Rights, Citizenship and Democracy Course by Teacher's Vision

    Science.gov (United States)

    Sahan, Gülsün; Tural, Aysegül

    2018-01-01

    Human Rights, Citizenship and Democracy Course draws attention to with topics such as human rights, effective citizenship. In terms of content, it has an important place in contemporary education concept. It is thought that the Human Rights, Citizenship and Democracy course will benefit the social structure because of its content and the outputs…

  17. Situated Meaning-Making of the Human Body: A Study of Elementary School Children's Reasons in Two Different Activities

    Science.gov (United States)

    Lundin, Mattias; Jakobson, Britt

    2014-01-01

    In this text we compare children's expressions in drawings to their statements during interviews, for the purpose of understanding how different situations afford children to make meaning. In specific we study how two different activities interact and afford children to make meaning differently about the human body. The analytic attention is…

  18. School Nurses' Knowledge, Attitudes, Perceptions of Role as Opinion Leader, and Professional Practice Regarding Human Papillomavirus Vaccine for Youth

    Science.gov (United States)

    Rosen, Brittany L.; Goodson, Patricia; Thompson, Bruce; Wilson, Kelly L.

    2015-01-01

    Background: Because human papillomavirus (HPV) vaccine rates remain low, we evaluated US school nurses' knowledge, attitudes, perceptions of their role as opinion leaders, and professional practice regarding HPV vaccine, and assessed whether knowledge, attitudes, and perceptions of being an opinion leader influenced their professional…

  19. At the Very Root of the Development of Interest: Using Human Body Contexts to Improve Women's Emotional Engagement in Introductory Physics

    Science.gov (United States)

    Allaire-Duquette, Geneviève; Charland, Patrick; Riopel, Martin

    2014-01-01

    In physics, women find contexts concerning human biology, medical applications, or natural phenomena highly relevant (Hoffmann, 2002), and the rareness or absence of these in physics curricula may make it more difficult for women to develop and maintain their interest in physics. To date, research in physics education addressing student's…

  20. The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice.

    Directory of Open Access Journals (Sweden)

    Carola I F Janssen

    Full Text Available Apolipoprotein E4 (ApoE4, one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD. ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protects against high-fat (HF diet induced neurodegeneration by its role in the maintenance of the integrity of the blood-brain barrier. The influence of a HF diet on the progression of AD-like cognitive and neuropathological changes was assessed in wild-type (WT, human ApoE4 and ApoE-knockout (ApoE-/- mice to evaluate the modulatory role of ApoE in this process. From 12 months of age, female WT, ApoE4, and ApoE-/- mice were fed either a standard or a HF diet (19% butter, 0.5% cholate, 1.25% cholesterol throughout life. At 15 months of age mice performed the Morris water maze, evaluating spatial learning and memory. ApoE-/- showed increased spatial learning compared to WT mice (p = 0.009. HF diet improved spatial learning in WT mice (p = 0.045, but did not affect ApoE4 and ApoE-/- mice. Immunohistochemical analyses of the hippocampus demonstrated increased neuroinflammation (CD68 in the cornu ammonis 1 (CA1 region in ApoE4 (p = 0.001 and in ApoE-/- (p = 0.032 mice on standard diet. HF diet tended to increase CD68 in the CA1 in WT mice (p = 0.052, while it decreased in ApoE4 (p = 0.009, but ApoE-/- remained unaffected. A trend towards increased neurogenesis (DCX was found in both ApoE4 (p = 0.052 and ApoE-/- mice (p = 0.068. In conclusion, these data suggest that HF intake induces different effects in WT mice compared to ApoE4 and ApoE-/- with respect to markers for cognition and neurodegeneration. We propose that HF intake inhibits the compensatory mechanisms of neuroinflammation and neurogenesis in aged female ApoE4 and ApoE-/- mice.

  1. I'm Not for Sale: Teaching about Human Trafficking

    Science.gov (United States)

    Moore, James

    2018-01-01

    Even though slavery is illegal in all countries, it is still practiced in the form of human trafficking. In fact, there are about twenty-five million men, women, and children who are victims of human trafficking, a 150-billion-dollar industry that affects every country across the globe. Modern communications, such as the Internet and cell phones,…

  2. The Future of the Humanities in Today's Financial Markets

    Science.gov (United States)

    Lea, David

    2014-01-01

    In this essay David Lea approaches the decline in the study and teaching of the humanities within the university context from a financial perspective. As humanities departments are either closed down or have their curriculum attenuated, it is obvious that the revenue previously available to support such programs has not been forthcoming. This…

  3. 'et' special: ''E-world of energy''; 'et'-special: ''E-world of energy''

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2001-02-01

    The 'et' special on the conference 'E-world of energy', held from February 13 - 15, 2001 in Essen (Germany) presents contributions of experts who offer solutions to issues and many topical questions arising in the business of traders and utilities as participants of (international) energy markets at various stages of transition towards workable competition. The translated titles of the 15 contributions reproduced in this 'et' special indicate the major contents of the conference papers: 1. Internet-based wholesale power trading as a competitive option to the power exchange. 2. Forward graphs in European electricity markets. 3. Portfolio management in energy trading. 4. Risk management concepts in energy trading. 5. E-commerce as a driving force of a change in the energy markets. 6. eHuman resources management - a vital aspect of corporate success. 7. A brand policy for electricity? 8. Is it really only the price that counts for the customers? 9. The City Power network: an example of successful customer loyalty strategy for local and regional utilities. 10. The Call Center, an important instrument for customer loyalty programmes. 11. eCommerce or eLlusion? 12. eBusiness as a corporate strategy. 13. Meeting the challenges of increasing IT requirements. 14. IT solutions for transmission and distribution network management. 15. Target costing - pinpointed cost planning and control for the energy supply industry. (orig./CB) [German] In dem 'et'-Special zur Konferenz 'E-world of energy', die vom 13.- 15. Februar 2001 in Essen stattfand, bieten Experten Loesungsvorschlaege fuer die aktuellen Fragen und Probleme an, die sich auf dem Weg zu liberalisierten Energiemaerkten stellen. Die folgenden Titel der 15 Beitraege geben eine Uebersicht ueber den Inhalt der Konferenzbeitraege. Themen: 1. Internetbasierte Grosshandelsmaerkte als Konkurrenz zu Energieboersen 2. Forward-Kurven in europaeischen Strommaerkten 3

  4. A social network's changing statistical properties and the quality of human innovation

    Energy Technology Data Exchange (ETDEWEB)

    Uzzi, Brian [Kellogg School of Management, Northwestern University, Evanston, IL (United States)], E-mail: uzzi@northwestern.edu

    2008-06-06

    We examined the entire network of creative artists that made Broadway musicals, in the post-War period, a collaboration network of international acclaim and influence, with an eye to investigating how the network's structural features condition the relationship between individual artistic talent and the success of their musicals. Our findings show that some of the evolving topographical qualities of degree distributions, path lengths and assortativity are relatively stable with time even as collaboration patterns shift, which suggests their changes are only minimally associated with the ebb and flux of the success of new productions. In contrast, the clustering coefficient changed substantially over time and we found that it had a nonlinear association with the production of financially and artistically successful shows. When the clustering coefficient ratio is low or high, the financial and artistic success of the industry is low, while an intermediate level of clustering is associated with successful shows. We supported these findings with sociological theory on the relationship between social structure and collaboration and with tests of statistical inference. Our discussion focuses on connecting the statistical properties of social networks to their performance and the performance of the actors embedded within them.

  5. Preserving technical knowledge - when technology's lifetime exceeds the human life span

    Energy Technology Data Exchange (ETDEWEB)

    Menely, D. [Atomic Energy of Canada Limited, Mississauga, Ontario, (Canada); Garland, W. [McMaster Univ., Hamilton, Ontario (Canada); Lightfoot, M.; Safa, M. [CANDU Owners Group, Toronto, Ontario (Canada)

    2006-12-15

    Industry is being challenged by the departure of experienced managers and workers. The loss of skills and the difficulty of finding qualified replacements can negatively affect operations, environment, safety and economics. There is a need to capture, preserve and pass along both documented and undocumented knowledge before aging workers depart the workplace. How to do it? Our ancestors faced the same problem, and they often solved it in a personal way through a Master-Journeyman-Apprentice system. Our modern education system is an extension of that system, augmented by extensive use of textbooks. This system now is stretched to its limits by two factors, (a) the need to update the teacher's knowledge, and (b) the need to update high quality textbooks. Modem Masters are so busy doing their work that they have no time to pass knowledge on in an effective manner. When they retire, their knowledge often is lost. The CANTEACH project was initiated to fill this gap. The essence of this knowledge capture process is acquisition of archival documents that are relevant to current practice in the field-in our case, CANDU power plant engineering. This project is made possible by voluntary contributions from Masters in the field; it can proceed only by avoiding the pitfalls of excessive security and intellectual property rules. This paper describes the mechanisms used to make this archival knowledge openly available for operators, designers, educators, and students of this technology. (author)

  6. Human Events Reference for ATHEANA (HERA) Database Description and Preliminary User's Manual

    Energy Technology Data Exchange (ETDEWEB)

    Auflick, J.L.

    1999-08-12

    The Technique for Human Error Analysis (ATHEANA) is a newly developed human reliability analysis (HRA) methodology that aims to facilitate better representation and integration of human performance into probabilistic risk assessment (PRA) modeling and quantification by analyzing risk-significant operating experience in the context of existing behavioral science models. The fundamental premise of ATHEANA is that error forcing contexts (EFCs), which refer to combinations of equipment/material conditions and performance shaping factors (PSFs), set up or create the conditions under which unsafe actions (UAs) can occur. Because ATHEANA relies heavily on the analysis of operational events that have already occurred as a mechanism for generating creative thinking about possible EFCs, a database (db) of analytical operational events, called the Human Events Reference for ATHEANA (HERA), has been developed to support the methodology. This report documents the initial development efforts for HERA.

  7. o'Peer: open peer review

    International Nuclear Information System (INIS)

    Brewer, J H

    2014-01-01

    I have built a ''demonstration'' website at http://oPeer.org to illustrate how peer review and publication might be improved relative to the current model, which was designed and implemented in an era when scientific communication was either face-to-face or relied upon human delivery of ink marks on dead trees

  8. The Existential Concern of the Humanities R. S. Peters' Justification of Liberal Education

    Science.gov (United States)

    Cuypers, Stefaan E.

    2018-01-01

    Richard Stanley Peters was one of the founding fathers of analytic philosophy of education in the twentieth century. After reviewing Peters' disentanglement of the ambiguities of liberal education, I reconstruct his view on the status and the existential foundations of the humanities. What emerges from my reconstruction is an original…

  9. Computing the English Middle Ages: A Sociotechnical Study of Medievalists' Engagement with Digital Humanities

    Science.gov (United States)

    Simpson, Grant Leyton

    2017-01-01

    With few exceptions, digital humanities projects and objects have been described rather than studied. This dissertation attempts to advance that discourse by empirically studying, from a sociotechnical point of view, DH projects and the products they produce, specifically those within the realm of Old and Middle English language and literature.…

  10. Solar Energy Education. Humanities: activities and teacher's guide. Field test edition

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    Activities are outlined to introduce students to information on solar energy while performing ordinary classroom work. In this teaching manual solar energy is integrated with the humanities. The activities include such things as stories, newspapers, writing assignments, and art and musical presentations all filled with energy related terms. An energy glossary is provided. (BCS)

  11. The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells.

    Science.gov (United States)

    Varela, Lourdes M; Ortega-Gomez, Almudena; Lopez, Sergio; Abia, Rocio; Muriana, Francisco J G; Bermudez, Beatriz

    2013-12-01

    Intestinally produced triglyceride-rich lipoproteins (TRL) play an important role in the progression of atherosclerosis. In this study, we investigated the relevance of monounsaturated fatty acid (MUFA) and saturated fatty acid (SFA) in postprandial TRL in affecting the transcriptional activity of the apolipoprotein-B48 receptor (ApoB48R) and its functionality in human monocyte/macrophage cells. Healthy male volunteers were administered four standardized high-fat meals containing butter, high-palmitic sunflower oil, olive oil (ROO) or a mixture of vegetable and fish oils (50 g/m(2) body surface area) to obtain a panel of postprandial TRL with gradual MUFA oleic acid-to-SFA palmitic acid ratios. The increase in this ratio was linearly associated with a decrease of ApoB48R up-regulation and lipid accumulation in THP-1 and primary monocytes. ApoB48R mRNA levels and intracellular triglycerides were also lower in the monocytes from volunteers after the ingestion of the ROO meal when compared to the ingestion of the butter meal. In THP-1 macrophages, the increase in the MUFA oleic acid-to-SFA palmitic acid ratio in the postprandial TRL was linearly correlated with an increase in ApoB48R down-regulation and a decrease in lipid accumulation. We also revealed that the nuclear receptor transcription factors PPARα, PPARβ/δ, and PPARγ and the PPAR-RXR transcriptional complex were involved in sensing the proportion of MUFA oleic acid and SFA palmitic acid, and these were also involved in adjusting the transcriptional activity of ApoB48R. The results of this study support the notion that MUFA-rich dietary fats may prevent excessive lipid accumulation in monocyte/macrophage cells by targeting the postprandial TRL/ApoB48R axis. © 2013.

  12. ''Old'' locked inflation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yang; Piao, Yun-Song [College of Physical Sciences, Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Si, Zong-Guo, E-mail: liuyangbyf@mail.sdu.edu.cn, E-mail: yspiao@gucas.ac.cn, E-mail: zgsi@sdu.edu.cn [Department of Physics, Shandong University, Jinan 250100 (China)

    2009-05-15

    In this paper, we revisit the idea of locked inflation, which does not require a potential satisfying the normal slow-roll condition, but suffers from the problems associated with ''saddle inflation''. We propose a scenario based on locked inflation, however, with an alternative evolution mechanism of the ''waterfall field'' {phi}. Instead of rolling down along the potential, the {phi} field will tunnel to end the inflation stage like in old inflation, by which the saddle inflation could be avoided. Further, we study a cascade of old locked inflation, which can be motivated by the string landscape. Our model is based on the consideration of making locked inflation feasible so as to give a working model without slow roll; It also can be seen as an effort to embed the old inflation in string landscape.

  13. Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.

    Science.gov (United States)

    Dresselhaus, Erica; Duerr, James M; Vincent, Fabien; Sylvain, Emily K; Beyna, Mercedes; Lanyon, Lorraine F; LaChapelle, Erik; Pettersson, Martin; Bales, Kelly R; Ramaswamy, Gayathri

    2018-01-01

    Despite the important role of apolipoprotein E (apoE) secretion from astrocytes in brain lipid metabolism and the strong association of apoE4, one of the human apoE isoforms, with sporadic and late onset forms of Alzheimer's disease (AD) little is known about the regulation of astrocytic apoE. Utilizing annotated chemical libraries and a phenotypic screening strategy that measured apoE secretion from a human astrocytoma cell line, inhibition of pan class I histone deacetylases (HDACs) was identified as a mechanism to increase apoE secretion. Knocking down select HDAC family members alone or in combination revealed that inhibition of the class I HDAC family was responsible for enhancing apoE secretion. Knocking down LXRα and LXRβ genes revealed that the increase in astrocytic apoE in response to HDAC inhibition occurred via an LXR-independent pathway. Collectively, these data suggest that pan class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.

  14. Nanosized fibers' effect on adult human articular chondrocytes behavior

    Energy Technology Data Exchange (ETDEWEB)

    Stenhamre, Hanna [Biopolymer Technology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg (Sweden); Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg (Sweden); Thorvaldsson, Anna, E-mail: anna.thorvaldsson@swerea.se [Biopolymer Technology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg (Sweden); Swerea IVF, Mölndal (Sweden); Enochson, Lars [Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg (Sweden); Walkenström, Pernilla [Swerea IVF, Mölndal (Sweden); Lindahl, Anders [Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg (Sweden); Brittberg, Mats [Cartilage Research Unit, University of Gothenburg, Department Orthopaedics, Kungsbacka Hospital, Kungsbacka (Sweden); Gatenholm, Paul [Biopolymer Technology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg (Sweden)

    2013-04-01

    Tissue engineering with chondrogenic cell based therapies is an expanding field with the intention of treating cartilage defects. It has been suggested that scaffolds used in cartilage tissue engineering influence cellular behavior and thus the long-term clinical outcome. The objective of this study was to assess whether chondrocyte attachment, proliferation and post-expansion re-differentiation could be influenced by the size of the fibers presented to the cells in a scaffold. Polylactic acid (PLA) scaffolds with different fiber morphologies were produced, i.e. microfiber (MS) scaffolds as well as nanofiber-coated microfiber scaffold (NMS). Adult human articular chondrocytes were cultured in the scaffolds in vitro up to 28 days, and the resulting constructs were assessed histologically, immunohistochemically, and biochemically. Attachment of cells and serum proteins to the scaffolds was affected by the architecture. The results point toward nano-patterning onto the microfibers influencing proliferation of the chondrocytes, and the overall 3D environment having a greater influence on the re-differentiation. In the efforts of finding the optimal scaffold for cartilage tissue engineering, studies as the current contribute to the knowledge of how to affect and control chondrocytes behavior. - Highlights: ► Chondrocyte behavior in nanofiber-coated microfiber versus microfiber scaffolds ► High porosity (> 90%) and large pore sizes (a few hundred μm) of nanofibrous scaffolds ► Proliferation enhanced by presence of nanofibers ► Differentiation not significantly affected ► Cell attachment improved in presence of both nanofibers and serum.

  15. Comparing Swedish and Norwegian Teachers' Professional Development: How Human Capital and Social Capital Factor into Teachers' Reading Habits

    Science.gov (United States)

    Reichenberg, Monica; Andreassen, Rune

    2018-01-01

    The present study compares how Swedish (n = 340) and Norwegian (n = 236) teachers' human capital and social capital support reading habits as an aspect of professional development. The overall aim was to describe how teachers' human and social capital support their professional development as measured by the aspect of reading habits during leisure…

  16. Renewable energies in the service of humanity. 40. anniversary of the congress 'The sun in the Service of Mankind' 1973-2013. Current challenges and prospects by 2030 and 2050

    International Nuclear Information System (INIS)

    Campana, Dominique; D'Adesky, Marie; Bolinches, Christine; Caillierez, Laurent; Schwarz, Virginie; Varet, Anne; Moisan, Francois; Lechevin, Bruno; Dollet, Alain; Lincot, Daniel; Bertrand, Joel; Benchikh, Osman; Kalonji, Gretchen; Palz, Wolfgang; Lins, Christine; Frankl, Paolo; ); Wouters, Frank; Swanson, Richard; Tiwari, Ayodhya; Yamaguchi, Masafumi; Flamant, Gilles; Maegaard, Preben; Kariniotakis, Georges; Roy, Claude; Rayol, Caroline; Duplan, Jean-Luc; Boeuf, Marc; Sanner, Burkard; Graff, Jean-Jacques; Chabrillat, Remi; Hadjsaid, Nouredine; Tarascon, Jean-Marie; Priem, Thierry; Vidal, Olivier; Alt, Franz; Bal, Jean-Louis; Ould-Dada, Zitouni; ); Kappiah, Mahama; Allal, Houda; Eckhart, Michael; Gromard, Christian de; Benchikh, Osman; Marzin, Jean-Yves; Aubert, Marie Helene; Yumkella, Kandeh K.; Lalonde, Brice

    2015-03-01

    The 'Renewable energies in the service of humanity' international scientific symposium took place in Paris together with the ceremony that marked the 40. anniversary of the first international congress 'The Sun in the service of mankind', held at UNESCO in 1973. This event was intended to show the progress achieved over 40 years of development in renewable energies, but also the energy and climate challenges to be faced before 2050. Indeed, this is the date by which we must have successfully cut our current greenhouse gas emissions (GHG) by four to limit global warming below 2 deg. C above pre-industrial levels. For the first time in 1973, almost 900 scientists gathered to launch an initiative that aimed to promote research on solar energy, aware that the development of this inexhaustible renewable energy could strongly benefit the future well-being of humanity. The ensuing forty years and above all recent times, have proved these forerunners right. Renewable energy has indeed experienced extraordinary growth, whether it is solar power, particularly photovoltaic, but also wind power, or even biomass. The International Energy Agency (IEA) estimates that renewable energy will represent a third of all electricity produced by 2035. Driven by the same global ambition as the 1973 congress, the French Environment and Energy Management Agency (ADEME), the French National Scientific Research Centre (CNRS) and the United Nations Educational, Scientific and Cultural Organization (UNESCO) have jointly organised this international meeting on the current challenges and prospects for renewable energies by 2030 and 2050. High-level experts and representatives from international organisations discussed the global scientific, technical, political, economic and social aspects of the various branches in the renewable energies field. The aim was to assess the development of renewable energies, put their contribution to global energy transition into perspective and

  17. The role of nucleoside/nucleotide transport and metabolism in the uptake and retention of 3'-fluoro-3'-deoxythymidine in human B-lymphoblast cells

    Energy Technology Data Exchange (ETDEWEB)

    Plotnik, David A.; McLaughlin, Lena J.; Chan, Jenny; Redmayne-Titley, Joshua N.; Schwartz, Jeffrey L., E-mail: jschwart@uw.edu

    2011-10-15

    Introduction: Recent studies in the human adenocarcinoma cell line A549 have identified cell growth-dependent equilibrative nucleoside transporter-1 (hENT1) as a modifier of 3'-fluoro-3'-deoxythymidine (FLT) uptake and retention. In the present study, we used the ability to isolate human lymphoblastoid clones deficient in thymidine kinase 1 (TK1) to study how metabolism and nucleoside transport influence FLT uptake and retention. Methods: Transport and metabolism of FLT were measured in the human lymphoblastoid cell line TK6 and in eight clones isolated from TK6. Four clones were TK1-proficient, while four were TK1-deficient. Both influx and efflux of FLT were measured under conditions where concentrative and equilibrative transport could be distinguished. Results: Sodium-dependent concentrative FLT transport dominated over equilibrative transport mechanisms and while inhibition of hENT1 reduced FLT uptake, there were no correlations between clonal variations in hENT1 levels and FLT uptake. There was an absolute requirement of TK1 for concentration of FLT in TK6 cells. FLT uptake reached a peak after 60 min of incubation with FLT after which intracellular levels of FLT and FLT metabolites declined. Efflux was rapid and was associated with reductions in FLT and each of its metabolites. Both FLT and FLT-monophosphate were found in the efflux buffer. Conclusions: Initial rates of FLT uptake were a function of both concentrative and equilibrative transporters. TK1 activity was an absolute requirement for the accumulation of FLT. Retention was dependent on nucleoside/nucleotide efflux and retrograde metabolism of FLT nucleotides.

  18. Anglo-French Collaboration in the Nuclear Sector: The Human, Social and Ethical Dimensions. Graduate seminar, Maison Francaise d'Oxford, Monday 15 May 2017

    International Nuclear Information System (INIS)

    Denoun, Martin; Tsuchiya, Miyuki; Degremont-Dorville, Marie; Bouillet, Jeremy; Deront, Eva; Kim, Tae-Hoon; Kobylka, Krzysztof; Nithesh, Antony; Defard, Camille; Giachetti, Charles; Nivole, Audrey; Takahashi, Makoto; Pini, Paul-Etienne; Lloyd, Clara

    2017-05-01

    A graduate workshop was held on Monday 15 May, at the Maison francaise d'Oxford, involving a little group of graduate students, from the UK and France. They were invited to present their research and to engage in discussions over the place of nuclear energy in the context of the social sciences and humanities. Wider issues of relevance and interest regarding nuclear energy - such as its human, cultural and philosophical dimensions - have not received sufficient attention in either France or Britain. A number of specific areas were identified to be significant in this respect: - The need for clearer, 'unbiased' information, explanations and better understanding of the wider human dimensions associated with nuclear energy. - A better understanding of the influences upon, and differences in social attitudes towards nuclear in France and Britain. - The factors influencing varying attitudes within Britain and France amongst different sections of society. Particular references were made to the younger age groups and gender differences. - And understanding of 'changes' of attitude and support found in Britain and France, in more recent times. - The importance of the community, social, cultural, ethical and human dimensions given the unique nature of the nuclear sector, and in particular the long term nature and scale of economic and social investments associated with nuclear energy. - The impact of perceptions about the nuclear risk factors that may, or may not, be very different to reality over time. - The global nature of the impact of the sector on Anglo-French interests and the opportunities for positive collaboration, and learning in the wider human, social, ethical, cultural and philosophical aspects. - The multitude of social media channels available for disseminating information and opinions that influence social attitudes about nuclear energy. - A lack of trust in policy or operational statements emanating from the government, company or

  19. The strategic ''pull'' and operational ''push'' of total quality management in UK regional electricity service companies

    Energy Technology Data Exchange (ETDEWEB)

    McAdam, R.; McLean, J.; Henderson, J.

    2003-04-30

    The aim of this paper is to evaluate whether the UK regional electricity companies (RECs) has used total quality management (TQM) as a ''push'' or as a ''pull'' change methodology. ''Push'' is the operational improvement role of TQM; ''pull'' is the strategic or direction giving, improvement role of TQM. Following the onset of privatisation in 1990 there has been evidence of the RECs adopting TQM in both ''push'' and ''pull'' methodologies with varying degrees of success. An evaluation of the change processes involved will enable improved change models to be developed leading to increased business effectiveness in this 30 billion pounds sterling industry. Other possible benefits include the possible generalisations to other utilities such as water, roads, gas and telecoms. The research methodology includes a comparative case study analysis of five RECs, which have used TQM as their overarching approach to change. One of the cases is analysed to a more in-depth level based on the multiple case findings. The findings indicate that the ''push-pull'' analysis enables the full range of TQM activities to be evaluated in the RECs studied. Overall, there is a need to have a balanced portfolio of operational or ''push''-based TQM activity that is driven by strategic or ''pull'' based TQM planning and activity. (author)

  20. Additive effects of 5-Aza-2'-deoxycytidine and irradiation on clonogenic survival of human medulloblastoma cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Patties, Ina; Jahns, Jutta; Kortmann, Rolf-Dieter; Glasow, Annegret [Dept. of Radiotherapy and Radiooncology, Universitaetsklinikum Leipzig AoeR (Germany); Hildebrandt, Guido [Dept. of Radiotherapy and Radiooncology, Universitaetsklinikum Leipzig AoeR (Germany); Dept. of Radiotherapy, Univ. of Rostock (Germany)

    2009-05-15

    Background and purpose: in recent years, epigenetic modulators were introduced into tumor therapy. Here, the authors investigated the antitumor effect of 5-aza-2'-deoxycytidine-(5-aza-dC-)induced demethylation combined with irradiation on human medulloblastoma (MB) cells, which form the most common malignant brain tumor in children. Material and methods: three MB cell lines were treated with 5-aza-dC in a low-dose (0.1 {mu}M, 6 days) or high-dose (3/5 {mu}M, 3 days) setting and irradiated with 2, 4, 6, or 8 Gy single dose on an X-ray unit. Methylation status and mRNA expression of three candidate genes were analyzed by methylation-specific PCR (polymerase chain reaction) and quantitative real-time RT-PCR. Cell survival and mortality were determined by trypan blue exclusion test. Proliferation was analyzed by BrdU incorporation assay, and long-term cell survival was assessed by clonogenic assay. Results: 5-aza-dC treatment resulted in partial promoter demethylation and increased expression of hypermethylated candidate genes. A significant decrease of vital cell count, proliferation inhibition and increase of mortality was observed in 5-aza-dC-treated as well as in irradiated MB cells, whereby combination of both treatments led to additive effects. Although high-dose 5-aza-dC treatment was more effective in terms of demethylation, clonogenic assay revealed no differences between high- and low-dose settings indicating no relevance of 5-aza-dC-induced demethylation for decreased cell survival. MB cells pretreated with 5-aza-dC showed significantly lower plating efficiencies than untreated cells at all irradiation doses investigated. Analysis of surviving curves in irradiated MB cells, however, revealed no significant differences of {alpha}-, {beta}-values and 2-Gy surviving fraction with or without 5-aza-dC treatment. Conclusion: 5-aza-dC did not enhance radiation sensitivity of MB cells but significantly reduced the clonogenicity versus irradiation alone, which

  1. Proteomic analysis reveals the enhancement of human serum apolipoprotein A-1(APO A-1) in individuals infected with multiple dengue virus serotypes.

    Science.gov (United States)

    Manchala, Nageswar Reddy; Dungdung, Ranjeet; Pilankatta, Rajendra

    2017-10-01

    Human serum protein profiling of the individual infected with multiple dengue virus serotypes for identifying the potential biomarkers and to investigate the cause for the severity of dengue virus infection. Dengue virus NS1-positive serum samples were pooled into two groups (S2 and S3) based on the molecular serotyping and number of heterotypic infections. The pooled serum samples were subjected to two-dimensional gel electrophoresis (2DGE) to identify the differentially expressed proteins. The peptide masses of upregulated protein were detected by matrix-assisted laser desorption-ionisation time-of-flight MALDI-TOF mass spectrometry and analysed by MASCOT search engine. The results were compared with the control group (S1). The commonly upregulated protein was validated by quantitative ELISA and compared with control as well as single serotypic infected samples. Based on 2DGE, total thirteen proteins were differentially upregulated in S2 and S3 groups as compared to control. Some of the upregulated proteins were involved in mediating the complement activation of immune response. The apolipoprotein A-1 (APO A-1) was upregulated in S2 and S3 groups. Upon validation, APO A-1 levels were increased in line with the number of heterotypic infection of dengue viruses. Heterotypic infection of dengue viruses upregulate the serum proteins involved in the complement pathway in the early phase of infection. There was a significant increase in the level of APO A-1 in three different serotypic infections of dengue virus as compared to control. Further, the role of APO-A1 can be explored in elucidating the mechanism of dengue pathogenesis. © 2017 John Wiley & Sons Ltd.

  2. Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells

    Czech Academy of Sciences Publication Activity Database

    Doubravská, Lenka; Šímová, Šárka; Čermák, Lukáš; Valenta, Tomáš; Kořínek, Vladimír; Anděra, Ladislav

    2008-01-01

    Roč. 13, č. 4 (2008), s. 573-587 ISSN 1360-8185 Institutional research plan: CEZ:AV0Z50520514 Keywords : Wnt * Apo2L/TRAIL * pre-B lymphocyte Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.971, year: 2008

  3. Just Like All the Other Humans? Analyzing Images of Scientists in Children's Trade Books

    Science.gov (United States)

    Rawson, Casey H.; McCool, Megan Astolfi

    2014-01-01

    Despite the efforts of researchers and national science organizations to recruit more women and minorities into the science and engineering workforce, these fields are still largely dominated by White males. Research suggests that children's mental prototypes of the scientist include a variety of negative and stereotypical features that may…

  4. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)

    Energy Technology Data Exchange (ETDEWEB)

    Dombrovski, Luidmila; Dong, Aiping; Bochkarev, Alexey; Plotnikov, Alexander N. (Toronto)

    2008-09-17

    Cytosolic sulfotransferases (SULTs), often referred as Phase II enzymes of chemical defense, are a superfamily of enzymes that catalyze the transfer of a sulfonate group from 3{prime}-phosphoadenosine 5{prime}-phosphosulfate (PAPS) to an acceptor group of substrates. This reaction modulates the activities of a large array of small endogenous and foreign chemicals including drugs, toxic compounds, steroid hormones, and neurotransmitters. In some cases, however, SULTs activate certain food and environmental compounds to mutagenenic and carcinogenic metabolites. Twelve human SULTs have been identified, which are partitioned into three families: SULT1, SULT2 and SULT4. The SULT1 family is further divided in four subfamilies, A, B, C, and E, and comprises eight members (1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 1C3, and 1E1). Despite sequence and structural similarity among the SULTs, the family and subfamily members appear to have different biological function. SULT1 family shows substrate-binding specificity for simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs. Human SULT1B1 is expressed in liver, colon, small intestine, and blood leukocytes, and shows substrate-binding specificity to thyroid hormones and benzylic alcohols. Human SULT1C1 is expressed in the adult stomach, kidney, and thyroid, as well as in fetal kidney and liver. SULT1C1 catalyzes the sulfonation of p-nitrophenol and N-hydroxy-2-acetylaminofluorene in vitro. However, the in vivo function of the enzyme remains unknown. We intend to solve the structures for all of the SULTs for which structural information is not yet available, and compare the structural and functional features of the entire SULT superfamily. Here we report the structures of two members of SULT1 family, SULT1B1 and SULT1C1, both in complex with the product of the PAPS cofactor, adenosine-3{prime}-5{prime}-diphosphate (PAP).

  5. A new soybean variety ''Ichihime''

    International Nuclear Information System (INIS)

    Hajika, M.; Takahashi, M.; Igita, K.; Sakai, S.; Nakazawa, Y.

    2002-01-01

    Ichihime, a new soybean variety registered as ''Soybean Norin 103'', was developed at Kyushu National Agricultural Experiment Station in 1995. It was selected from the progeny induced by a cross between Kankei 2 and Kankei 1 using gamma-ray irradiation. ''Ichihime'' is a medium-early maturing variety with determinate growth. It has broad leaflets, and purple flowers. The color of its pubescence is light tawny and its pods are dark brown. The main stem length, number of main stem nodes, and seed size are medium. It has strong resistance to the soybean mosaic virus (SMV), medium resistance to the soybean cyst nematode, and medium resistance to purple seed stain. The yield of Ichihime is slightly lower than Suzuyutaka, but classified as medium. The protein components of its seeds are medium and the firmness of the tofu (soybean curd) is the same as that of Suzuyutaka. Ichihime lacks all seed lipoxygenase isozymes and is recommended for new type of soybean food processing materials. Ichihime is suitable for growth in the southern part of the Tohoku area and the northern part of the Kanto area

  6. In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE

    NARCIS (Netherlands)

    Dijk, K.W. van; Vlijmen, B.J.M. van; Hof, H.B. van 't; Zee, A. van der; Santamarina-Fojo, S.; Berkel, T.J.C. van; Havekes, L.M.; Hofker, M.H.

    1999-01-01

    To investigate the quantitative requirement for apolipoprotein (apo) E in the clearance of lipoproteins via the non-low density lipoprotein (LDL) receptor mediated pathway, human APOE was overexpressed at various levels in the livers of mice deficient for both the endogenous Apoe and Ldlr genes

  7. 'A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies'

    International Nuclear Information System (INIS)

    Marsden, Carolyn G; Wright, Mary Jo; Carrier, Latonya; Moroz, Krzysztof; Pochampally, Radhika; Rowan, Brian G

    2012-01-01

    The study of breast cancer metastasis depends on the use of established breast cancer cell lines that do not accurately represent the heterogeneity and complexity of human breast tumors. A tumor model was developed using primary breast tumor-initiating cells isolated from patient core biopsies that would more accurately reflect human breast cancer metastasis. Tumorspheres were isolated under serum-free culture conditions from core biopsies collected from five patients with clinical diagnosis of invasive ductal carcinoma (IDC). Isolated tumorspheres were transplanted into the mammary fat pad of NUDE mice to establish tumorigenicity in vivo. Tumors and metastatic lesions were analyzed by hematoxylin and eosin (H+E) staining and immunohistochemistry (IHC). Tumorspheres were successfully isolated from all patient core biopsies, independent of the estrogen receptor α (ERα)/progesterone receptor (PR)/Her2/neu status or tumor grade. Each tumorsphere was estimated to contain 50-100 cells. Transplantation of 50 tumorspheres (1-5 × 10 3 cells) in combination with Matrigel into the mammary fat pad of NUDE mice resulted in small, palpable tumors that were sustained up to 12 months post-injection. Tumors were serially transplanted three times by re-isolation of tumorspheres from the tumors and injection into the mammary fat pad of NUDE mice. At 3 months post-injection, micrometastases to the lung, liver, kidneys, brain and femur were detected by measuring content of human chromosome 17. Visible macrometastases were detected in the lung, liver and kidneys by 6 months post-injection. Primary tumors variably expressed cytokeratins, Her2/neu, cytoplasmic E-cadherin, nuclear β catenin and fibronectin but were negative for ERα and vimentin. In lung and liver metastases, variable redistribution of E-cadherin and β catenin to the membrane of tumor cells was observed. ERα was re-expressed in lung metastatic cells in two of five samples. Tumorspheres isolated under defined culture

  8. Generation of human induced pluripotent stem cells from a Bombay individual: Moving towards 'universal-donor' red blood cells

    Energy Technology Data Exchange (ETDEWEB)

    Seifinejad, Ali; Taei, Adeleh [Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, P.O. Box 19395-4644, ACECR, Tehran (Iran, Islamic Republic of); Totonchi, Mehdi; Vazirinasab, Hamed [Department of Genetics, Royan Institute for Reproductive Biomedicine, ACECR, Tehran (Iran, Islamic Republic of); Hassani, Seideh Nafiseh [Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, P.O. Box 19395-4644, ACECR, Tehran (Iran, Islamic Republic of); Aghdami, Nasser [Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, P.O. Box 19395-4644, ACECR, Tehran (Iran, Islamic Republic of); Department of Regenerative Biomedicine, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran (Iran, Islamic Republic of); Shahbazi, Ebrahim [Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, P.O. Box 19395-4644, ACECR, Tehran (Iran, Islamic Republic of); Yazdi, Reza Salman [Department of Genetics, Royan Institute for Reproductive Biomedicine, ACECR, Tehran (Iran, Islamic Republic of); Salekdeh, Ghasem Hosseini, E-mail: Salekdeh@royaninstitute.org [Department of Molecular Systems Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran (Iran, Islamic Republic of); Department of Systems Biology, Agricultural Biotechnology Research Institute of Iran, Karaj (Iran, Islamic Republic of); Baharvand, Hossein, E-mail: Baharvand@royaninstitute.org [Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, P.O. Box 19395-4644, ACECR, Tehran (Iran, Islamic Republic of); Department of Regenerative Biomedicine, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran (Iran, Islamic Republic of); Department of Developmental Biology, University of Science and Culture, ACECR, Tehran (Iran, Islamic Republic of)

    2010-01-01

    Bombay phenotype is one of the rare phenotypes in the ABO blood group system that fails to express ABH antigens on red blood cells. Nonsense or missense mutations in fucosyltransfrase1 (FUT1) and fucosyltransfrase2 (FUT2) genes are known to create this phenotype. This blood group is compatible with all other blood groups as a donor, as it does not express the H antigen on the red blood cells. In this study, we describe the establishment of human induced pluripotent stem cells (iPSCs) from the dermal fibroblasts of a Bombay blood-type individual by the ectopic expression of established transcription factors Klf4, Oct4, Sox2, and c-Myc. Sequence analyses of fibroblasts and iPSCs revealed a nonsense mutation 826C to T (276 Gln to Ter) in the FUT1 gene and a missense mutation 739G to A (247 Gly to Ser) in the FUT2 gene in the Bombay phenotype under study. The established iPSCs resemble human embryonic stem cells in morphology, passaging, surface and pluripotency markers, normal karyotype, gene expression, DNA methylation of critical pluripotency genes, and in-vitro differentiation. The directed differentiation of the iPSCs into hematopoietic lineage cells displayed increased expression of the hematopoietic lineage markers such as CD34, CD133, RUNX1, KDR, {alpha}-globulin, and {gamma}-globulin. Such specific stem cells provide an unprecedented opportunity to produce a universal blood group donor, in-vitro, thus enabling cellular replacement therapies, once the safety issue is resolved.

  9. Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors

    International Nuclear Information System (INIS)

    Chosdol, Kunzang; Misra, Anjan; Puri, Sachin; Srivastava, Tapasya; Chattopadhyay, Parthaprasad; Sarkar, Chitra; Mahapatra, Ashok K; Sinha, Subrata

    2009-01-01

    We had earlier used the comparison of RAPD (Random Amplification of Polymorphic DNA) DNA fingerprinting profiles of tumor and corresponding normal DNA to identify genetic alterations in primary human glial tumors. This has the advantage that DNA fingerprinting identifies the genetic alterations in a manner not biased for locus. In this study we used RAPD-PCR to identify novel genomic alterations in the astrocytic tumors of WHO grade II (Low Grade Diffuse Astrocytoma) and WHO Grade IV (Glioblastoma Multiforme). Loss of heterozygosity (LOH) of the altered region was studied by microsatellite and Single Nucleotide Polymorphism (SNP) markers. Expression study of the gene identified at the altered locus was done by semi-quantitative reverse-transcriptase-PCR (RT-PCR). Bands consistently altered in the RAPD profile of tumor DNA in a significant proportion of tumors were identified. One such 500 bp band, that was absent in the RAPD profile of 33% (4/12) of the grade II astrocytic tumors, was selected for further study. Its sequence corresponded with a region of FAT, a putative tumor suppressor gene initially identified in Drosophila. Fifty percent of a set of 40 tumors, both grade II and IV, were shown to have Loss of Heterozygosity (LOH) at this locus by microsatellite (intragenic) and by SNP markers. Semi-quantitative RT-PCR showed low FAT mRNA levels in a major subset of tumors. These results point to a role of the FAT in astrocytic tumorigenesis and demonstrate the use of RAPD analysis in identifying specific alterations in astrocytic tumors

  10. Optimal strategies for the abatement of gaseous air pollutant emissions produced by human mobility. The Rome case study; Strategie ottimali per la riduzione delle emissioni di inquinanti gassosi prodotte dalla mobilita' urbana. Un'applicazione al caso di Roma

    Energy Technology Data Exchange (ETDEWEB)

    Santostefano, S.; Cirillo, M.C. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1999-07-01

    In this paper a cost-effectiveness of gaseous vehicular emission reduction has been carried out for human mobility, over the transport network in Rome: in other words, once a reduction target of total emissions has been fixed for each pollutant, the most efficient abatement measures from a technical-economic point of view are selected. The optimization problem has been formalized considering linear functions both for the objective function and for constrains, i.e. within the classic linear programming framework, the objective being that of finding the diversion of present vehicular traffic to alternative technologies with lower emissions at minimum costs. A set of transport alternative measures has been considered and emission abatement cost minimization has been assumed as an objective function; specified abatements for CO (Carbon monoxide), NO{sub x} (nitrogen oxides) and VOC (Volatile Organic Compounds) emissions have been introduced as constraints to the problem, expressed as reduction rates of estimated present emissions in the considered area. Model results show the distribution of present transportation capacity among possible alternatives for different hypothesis of emission reduction rates (reduction of 25%, 50%, 75%, 85% of present emissions and maximum feasible reduction within the specified constraints), and related costs. [Italian] In questo rapporto e' stata condotta un'analisi costi-efficacia relativa alla riduzione delle emissioni gassose veicolari dovute alla mobilita' urbana sulla rete di trasporto di Roma: in altre parole, fissata una quota di abbattimento delle emissioni complessive per ogni inquinante, sono state individuate le misure piu' efficienti dal punto di vista tecnico-economico che permettono di perseguire la riduzione prefissata. Il problema di ottimizzazione e' stato formalizzato definendo sia la funzione obiettivo che i relativi vincoli come funzioni lineari, e quindi nell'ambito della programmazione

  11. DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Obara, Akio; Fujita, Yoshihito; Abudukadier, Abulizi; Fukushima, Toru; Oguri, Yasuo; Ogura, Masahito; Harashima, Shin-ichi; Hosokawa, Masaya; Inagaki, Nobuya, E-mail: inagaki@metab.kuhp.kyoto-u.ac.jp

    2015-05-15

    Metformin, one of the most commonly used drugs for patients with type 2 diabetes, recently has received much attention regarding its anti-cancer action. It is thought that the suppression of mTOR signaling is involved in metformin's anti-cancer action. Although liver cancer is one of the most responsive types of cancer for reduction of incidence by metformin, the molecular mechanism of the suppression of mTOR in liver remains unknown. In this study, we investigated the mechanism of the suppressing effect of metformin on mTOR signaling and cell proliferation using human liver cancer cells. Metformin suppressed phosphorylation of p70-S6 kinase, and ribosome protein S6, downstream targets of mTOR, and suppressed cell proliferation. We found that DEPTOR, an endogenous substrate of mTOR suppression, is involved in the suppressing effect of metformin on mTOR signaling and cell proliferation in human liver cancer cells. Metformin increases the protein levels of DEPTOR, intensifies binding to mTOR, and exerts a suppressing effect on mTOR signaling. This increasing effect of DEPTOR by metformin is regulated by the proteasome degradation system; the suppressing effect of metformin on mTOR signaling and cell proliferation is in a DEPTOR-dependent manner. Furthermore, metformin exerts a suppressing effect on proteasome activity, DEPTOR-related mTOR signaling, and cell proliferation in an AMPK-dependent manner. We conclude that DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in liver, and could be a novel target for anti-cancer therapy. - Highlights: • We elucidated a novel pathway of metformin's anti-cancer action in HCC cells. • DEPTOR is involved in the suppressing effect of metformin on mTOR signaling. • Metformin increases DEPTOR protein levels via suppression of proteasome activity. • DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action.

  12. Everyman's prostate phantom: kiwi-fruit substitute for human prostates at magnetic resonance imaging, diffusion-weighted imaging and magnetic resonance spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Lisse, Ullrich G.; Murer, Sophie; Kuhn, Marissa [University of Munich (' ' Ludwig-Maximilians-Universitaet' ' , LMU), Department of Radiology, Faculty of Medicine, Muenchen (Germany); Mueller-Lisse, Ulrike L. [University of Munich (' ' Ludwig-Maximilians-Universitaet' ' , LMU), Department of Urology, Faculty of Medicine, Muenchen (Germany); Interdisciplinary Oncology Centre Munich (IOZ), Department of Urology, Munich (Germany); Scheidler, Juergen [University of Munich (' ' Ludwig-Maximilians-Universitaet' ' , LMU), Department of Radiology, Faculty of Medicine, Muenchen (Germany); Radiology Centre Munich (RZM), Muenchen (Germany); Scherr, Michael [University of Munich (' ' Ludwig-Maximilians-Universitaet' ' , LMU), Department of Radiology, Faculty of Medicine, Muenchen (Germany); BG Unfallklinik Murnau, Department of Radiology, Murnau am Staffelsee (Germany)

    2017-08-15

    To apply an easy-to-assemble phantom substitute for human prostates in T2-weighted magnetic resonance imaging (T2WI), diffusion-weighted imaging (DWI) and 3D magnetic resonance spectroscopy (MRS). Kiwi fruit were fixed with gel hot and cold compress packs on two plastic nursery pots, separated by a plastic plate, and submerged in tap water inside a 1-L open-spout plastic watering can for T2WI (TR/TE 7500/101 ms), DWI (5500/61 ms, ADC b50-800 s/mm{sup 2} map) and MRS (940/145 ms) at 3.0 T, with phased array surface coils. One green kiwi fruit was additionally examined with an endorectal coil. Retrospective comparison with benign peripheral zone (PZ) and transitional zone (TZ) of prostate (n = 5), Gleason 6-7a prostate cancer (n = 8) and Gleason 7b-9 prostate cancer (n = 7) validated the phantom. Mean contrast between central placenta (CP) and outer pericarp (OP, 0.346-0.349) or peripheral placenta (PP, 0.364-0.393) of kiwi fruit was similar to Gleason 7b-9 prostate cancer and PZ (0.308) in T2WI. ADC values of OP and PP (1.27 ± 0.07-1.37 ± 0.08 mm{sup 2}/s x 10{sup -3}) resembled PZ and TZ (1.39 ± 0.17-1.60 ± 0.24 mm{sup 2}/s x 10{sup -3}), while CP (0.91 ± 0.14-0.99 ± 0.10 mm{sup 2}/s x 10{sup -3}) resembled Gleason 7b-9 prostate cancer (1.00 ± 0.25 mm{sup 2}/s x 10{sup -3}). MR spectra showed peaks of citrate and myo-inositol in kiwi fruit, and citrate and ''choline+creatine'' in prostates. The phantom worked with an endorectal coil, too. The kiwi fruit phantom reproducibly showed zones similar to PZ, TZ and cancer in human prostates in T2WI and DWI and two metabolite peaks in MRS and appears suitable to compare different MR protocols, coil systems and scanners. (orig.)

  13. DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells

    International Nuclear Information System (INIS)

    Obara, Akio; Fujita, Yoshihito; Abudukadier, Abulizi; Fukushima, Toru; Oguri, Yasuo; Ogura, Masahito; Harashima, Shin-ichi; Hosokawa, Masaya; Inagaki, Nobuya

    2015-01-01

    Metformin, one of the most commonly used drugs for patients with type 2 diabetes, recently has received much attention regarding its anti-cancer action. It is thought that the suppression of mTOR signaling is involved in metformin's anti-cancer action. Although liver cancer is one of the most responsive types of cancer for reduction of incidence by metformin, the molecular mechanism of the suppression of mTOR in liver remains unknown. In this study, we investigated the mechanism of the suppressing effect of metformin on mTOR signaling and cell proliferation using human liver cancer cells. Metformin suppressed phosphorylation of p70-S6 kinase, and ribosome protein S6, downstream targets of mTOR, and suppressed cell proliferation. We found that DEPTOR, an endogenous substrate of mTOR suppression, is involved in the suppressing effect of metformin on mTOR signaling and cell proliferation in human liver cancer cells. Metformin increases the protein levels of DEPTOR, intensifies binding to mTOR, and exerts a suppressing effect on mTOR signaling. This increasing effect of DEPTOR by metformin is regulated by the proteasome degradation system; the suppressing effect of metformin on mTOR signaling and cell proliferation is in a DEPTOR-dependent manner. Furthermore, metformin exerts a suppressing effect on proteasome activity, DEPTOR-related mTOR signaling, and cell proliferation in an AMPK-dependent manner. We conclude that DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in liver, and could be a novel target for anti-cancer therapy. - Highlights: • We elucidated a novel pathway of metformin's anti-cancer action in HCC cells. • DEPTOR is involved in the suppressing effect of metformin on mTOR signaling. • Metformin increases DEPTOR protein levels via suppression of proteasome activity. • DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action

  14. Pulmonary perfusion ''without ventilation''

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, C.N.; Sziklas, J.J.; Spencer, R.P.; Rosenberg, R.J.

    1983-12-01

    An 88-yr-old man, with prior left upper lobectomy and phrenic nerve injury, had a ventilation/perfusion lung image. Both wash-in and equilibrium ventilation images showed no radioactive gas in the left lung. Nevertheless, the left lung was perfused. A similar result was obtained on a repeat study 8 days later. Delayed images, during washout, showed some radioactive gas in the left lung. Nearly absent ventilation (but continued perfusion) of that lung might have been related to altered gas dynamics brought about by the prior lobectomy, a submucosal bronchial lesion, phrenic nerve damage, and limited motion of the left part of the diaphragm. This case raises the issue of the degree of ventilation (and the phase relationship between the lungs) required for the entry of radioactive gas into a diseased lung, and the production of a ''reversed ventilation/perfusion mismatch.''

  15. Trafficking as a Human Rights Violation: Is South Africa's Curriculum Stuck in a Traffick Jam?

    Science.gov (United States)

    du Preez, Petro; Simmonds, Shan

    2013-01-01

    Human trafficking is a form of modern day slavery and is often collectively referred to as a human rights violation. However, human trafficking is more complex than this suggests as this article attempts to demonstrate. It begins by describing the landscape of international trends in human trafficking, with particular attention to child…

  16. Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs

    Directory of Open Access Journals (Sweden)

    Whitney Mandolin J

    2008-09-01

    Full Text Available Abstract Background Apolipoprotein E (ApoE is a molecular scavenger in the blood and brain. Aberrant function of the molecule causes formation of protein and lipid deposits or "plaques" that characterize Alzheimer's disease (AD and atherosclerosis. There are three human isoforms of ApoE designated ε2, ε3, and ε4. Each isoform differentially affects the structure and function of the protein and thus the development of disease. Homozygosity for ApoE ε4 is associated with atherosclerosis and Alzheimer's disease whereas ApoE ε2 and ε3 tend to be protective. Furthermore, the ε2 form may cause forms of hyperlipoproteinemia. Therefore, introduction of ApoE ε3 may be beneficial to patients that are susceptible to or suffering from these diseases. Mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs are adult progenitor cells found in numerous tissues. They are easily expanded in culture and engraft into host tissues when administered appropriately. Furthermore, MSCs are immunosuppressive and have been reported to engraft as allogeneic transplants. In our previous study, mouse MSCs (mMSCs were implanted into the brains of ApoE null mice, resulting in production of small amounts of ApoE in the brain and attenuation of cognitive deficits. Therefore human MSCs (hMSCs are a promising vector for the administration of ApoE ε3 in humans. Results Unlike mMSCs, hMSCs were found not to express ApoE in culture; therefore a molecular screen was performed for compounds that induce expression. PPARγ agonists, neural stem cell conditioned medium, osteo-inductive media, dexamethasone, and adipo-inductive media (AIM were tested. Of the conditions tested, only AIM or dexamethasone induced sustained secretion of ApoE in MSCs and the duration of secretion was only limited by the length of time MSCs could be sustained in culture. Upon withdrawal of the inductive stimuli, the ApoE secretion persisted for a further 14 days. Conclusion The data

  17. Adaptive response to ionizing radiation in normal human skin fibroblasts. Enhancement of DNA repair rate and modulation of gene expression. Reponse adaptative au rayonnement ionisant des fibroblastes de peau humaine. Augmentation de la vitesse de reparation de l'ADN et variation de l'expression des genes

    Energy Technology Data Exchange (ETDEWEB)

    Toledo, S.M. de; Mitchel, R.E.J. (Atomic Energy of Canada Ltd., Chalk River, ON (Canada). Chalk River Nuclear Labs.); Azzam, E. (Atomic Energy of Canada Ltd., Chalk River, ON (Canada). Chalk River Nuclear Labs. Ottawa Univ., ON (Canada). Dept. of Biology); Raaphorst, G.P. (Ottawa Univ., ON (Canada). Dept. of Biology)

    Low doses and dose rates of ionizing radiation enhance the rate of DNA repair in human fibroblasts and protect the cells against radiation-induced micronucleus formation. Chronic exposures reduce the mRNA levels of the genes topoisomerase II and FACC-1 (Fanconi's anemia, group C). (authors). 11 refs., 1 tab., 2 figs.

  18. The 'mini' and 'micro' energy sources and their limitations; Les ''minis'' et ''micros'' sources d'energie et leurs limites

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2004-03-01

    The 'Science and defense 2003' colloquium took place in Paris on December 2 and 3. It was organized by the general delegation of armament (DGA), the French atomic energy commission (CEA) with the participation of the national center of scientific research (CNRS) and the French ministry of research and new technologies. The main topic was the needs and the solutions implemented in the domain of energy sources both for civil and military portable applications. This article make a general summary of the content of this colloquium only in the domain of small power energy sources: emergence of new miniaturized portable devices (phones, computers, cameras, autonomous medical systems, wireless communication systems, soldiers equipments, drones etc..), improvement of batteries energy density and price, new needs linked with new functionalities, technological challenges (energy generation and recovery systems, miniaturized fuel-cells, use of recoverable energy sources, implantation of power sources in the human body etc..), new technological files (new electrode materials, micron- or sub-micron scale mechanical and electronic components, sensors, micro-motors, transfer of microelectronics technologies, hybrid systems..), international competition. (J.S.)

  19. Single-molecule folding mechanisms of the apo- and Mg2+-bound states of human neuronal calcium sensor-1

    DEFF Research Database (Denmark)

    Naqvi, Mohsin M; Heiðarsson, Pétur Orri; Otazo, Mariela R

    2015-01-01

    , at least transiently, at resting Ca(2+) conditions. Here, we used optical tweezers to study the folding behavior of individual NCS-1 molecules in the presence of Mg(2+) and in the absence of divalent ions. Under tension, the Mg(2+)-bound state of NCS-1 unfolds and refolds in a three-state process...... in a variety of cellular processes in which it has been linked to a number of disorders such as schizophrenia and autism. Despite extensive studies on the Ca(2+)-activated state of NCS proteins, little is known about the conformational dynamics of the Mg(2+)-bound and apo states, both of which are populated...... by populating one intermediate state consisting of a folded C-domain and an unfolded N-domain. The interconversion at equilibrium between the different molecular states populated by NCS-1 was monitored in real time through constant-force measurements and the energy landscapes underlying the observed transitions...

  20. Results of Clinical Tests of Phytopreparation ''Tkis Nobati''

    International Nuclear Information System (INIS)

    Khositashvili, V.; Khositashvili, L.; Atuashvili, N.; Osmanova, V.; Chankseliani, Z.

    2005-01-01

    The present paper deals with the results of the study of natural vegetative extract of Folium pini. On the basis of multiple experiments it has been established that phytopreparation ''Tkis Nobati'' strengthens the leucocytoprotection of organism and improves physiological state in oncologic patients in the process of chemoradiotherapy treatment. The preparation ''Tkis Nobati'' provides the elimination of heavy metals from the organism. (author)

  1. Characterization and behavior in the environment of the crude oil ''Prestige''; Caracterisation et comportement dans l'environnement du fioul ''Prestige''

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    This study presents analysis realized on the crude oil of the tanker ''Prestige'' which sunk the 19 november 2002. The specifications on the product and its behavior in sea water are detailed. All the analysis are compared to the ''Erika'' crude oil. (A.L.B.)

  2. Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

    Science.gov (United States)

    Achariyar, Thiyagaragan M; Li, Baoman; Peng, Weiguo; Verghese, Philip B; Shi, Yang; McConnell, Evan; Benraiss, Abdellatif; Kasper, Tristan; Song, Wei; Takano, Takahiro; Holtzman, David M; Nedergaard, Maiken; Deane, Rashid

    2016-12-08

    Apolipoprotein E (apoE) is a major carrier of cholesterol and essential for synaptic plasticity. In brain, it's expressed by many cells but highly expressed by the choroid plexus and the predominant apolipoprotein in cerebrospinal fluid (CSF). The role of apoE in the CSF is unclear. Recently, the glymphatic system was described as a clearance system whereby CSF and ISF (interstitial fluid) is exchanged via the peri-arterial space and convective flow of ISF clearance is mediated by aquaporin 4 (AQP4), a water channel. We reasoned that this system also serves to distribute essential molecules in CSF into brain. The aim was to establish whether apoE in CSF, secreted by the choroid plexus, is distributed into brain, and whether this distribution pattern was altered by sleep deprivation. We used fluorescently labeled lipidated apoE isoforms, lenti-apoE3 delivered to the choroid plexus, immunohistochemistry to map apoE brain distribution, immunolabeled cells and proteins in brain, Western blot analysis and ELISA to determine apoE levels and radiolabeled molecules to quantify CSF inflow into brain and brain clearance in mice. Data were statistically analyzed using ANOVA or Student's t- test. We show that the glymphatic fluid transporting system contributes to the delivery of choroid plexus/CSF-derived human apoE to neurons. CSF-delivered human apoE entered brain via the perivascular space of penetrating arteries and flows radially around arteries, but not veins, in an isoform specific manner (apoE2 > apoE3 > apoE4). Flow of apoE around arteries was facilitated by AQP4, a characteristic feature of the glymphatic system. ApoE3, delivered by lentivirus to the choroid plexus and ependymal layer but not to the parenchymal cells, was present in the CSF, penetrating arteries and neurons. The inflow of CSF, which contains apoE, into brain and its clearance from the interstitium were severely suppressed by sleep deprivation compared to the sleep state. Thus, choroid plexus

  3. Involvement of mismatch repair proteins in adaptive responses induced by N-methyl-N'-nitro-N-nitrosoguanidine against {gamma}-induced genotoxicity in human cells

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Ayumi; Sakamoto, Yasuteru; Masumura, Kenichi; Honma, Masamitsu [Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501 (Japan); Nohmi, Takehiko, E-mail: nohmi@nihs.go.jp [Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501 (Japan)

    2011-08-01

    Highlights: {yields} Health effects of radiation should be evaluated in combination with chemicals. {yields} Here, we show that MNNG suppresses radiation-induced genotoxicity in human cells. {yields} Mismatch repair proteins play critical roles in the apparent adaptive responses. {yields} Chemical exposure may modulate radiation-induced genotoxicity in humans. - Abstract: As humans are exposed to a variety of chemical agents as well as radiation, health effects of radiation should be evaluated in combination with chemicals. To explore combined genotoxic effects of radiation and chemicals, we examined modulating effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a direct-acting methylating agent, against genotoxicity of {gamma}-radiation. Human lymphoblastoid TK6 cells and its mismatch-deficient derivative, i.e., MT1 cells, were treated with MNNG for 24 h before they were exposed to {gamma}-irradiation at a dose of 1.0 Gy, and the resulting genotoxicity was examined. In TK6 cells, the pretreatments with MNNG at low doses suppressed frequencies of the thymidine kinase (TK) gene mutation and micronucleus (MN) formation induced by {gamma}-irradiation and thus the dose responses of TK and MN assays were U-shaped along with the pretreatment doses of MNNG. In contrast, the genotoxic effects of MNNG and {gamma}-irradiation were additive in MT1 cells and the frequencies of TK mutations and MN induction increased along with the doses of MNNG. Apoptosis induced by {gamma}-radiation was suppressed by the pretreatments in TK6 cells, but not in MT1 cells. The expression of p53 was induced and cell cycle was delayed at G2/M phase in TK6, but not in MT1 cells, by the treatments with MNNG. These results suggest that pretreatments of MNNG at low doses suppress genotoxicity of {gamma}-radiation in human cells and also that mismatch repair proteins are involved in the apparent adaptive responses.

  4. Development and deployment of a novel ''yellow'' demulsifier for the gullfaks ''A'' platform

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, S.J.; Ingebrigtsen, T.; Breen, P.J.; Waage, J.; Thorstenson, T.; Melby, S.

    2006-03-15

    Oil producers are increasingly under pressure to produce their product in an environmentally sound manner. Releases to the environment are undesirable and, where permitted to make such releases, oil producers should minimise their environmental impact. The bulk of treatment chemicals designed to improve separation and provide clean water for disposal can themselves be harmful to the environment and must conform to very stringent rules to be considered environmentally acceptable, or ''green''. Here we present data on the development of a green demulsifier for Statoil's Gullfaks ''A'' platform, which not only meets the very stringent regulations but also exhibits a significant improvement in product performance. While the''bottle test'' remains the industry standard method for selecting demulsifiers, in recent years the ''mini trial'' method for product selection has gained favour. We describe using a combination of both methods for the development of the novel demulsifier technology described here. (Author) (tk)

  5. ''de novo'' aneurysms following endovascular procedures

    Energy Technology Data Exchange (ETDEWEB)

    Briganti, F.; Cirillo, S.; Caranci, F. [Department of Neurological Sciences, Services of Neuroradiology, ' ' Federico II' ' University, Naples (Italy); Esposito, F.; Maiuri, F. [Department of Neurological Sciences, Services of Neurosurgery, ' ' Federico II' ' University, Naples (Italy)

    2002-07-01

    Two personal cases of ''de novo'' aneurysms of the anterior communicating artery (ACoA) occurring 9 and 4 years, respectively, after endovascular carotid occlusion are described. A review of the 30 reported cases (including our own two) of ''de novo'' aneurysms after occlusion of the major cerebral vessels has shown some features, including a rather long time interval after the endovascular procedure of up to 20-25 years (average 9.6 years), a preferential ACoA (36.3%) and internal carotid artery-posterior communicating artery (ICA-PCoA) (33.3%) location of the ''de novo'' aneurysms, and a 10% rate of multiple aneurysms. These data are compared with those of the group of reported spontaneous ''de novo'' aneurysms after SAH or previous aneurysm clipping. We agree that the frequency of ''de novo'' aneurysms after major-vessel occlusion (two among ten procedures in our series, or 20%) is higher than commonly reported (0 to 11%). For this reason, we suggest that patients who have been submitted to endovascular major-vessel occlusion be followed up for up to 20-25 years after the procedure, using non-invasive imaging studies such as MR angiography and high-resolution CT angiography. On the other hand, periodic digital angiography has a questionable risk-benefit ratio; it may be used when a ''de novo'' aneurysm is detected or suspected on non-invasive studies. The progressive enlargement of the ACoA after carotid occlusion, as described in our case 1, must be considered a radiological finding of risk for ''de novo'' aneurysm formation. (orig.)

  6. Expression of Fas (CD95/APO-1) ligand by human breast cancers: significance for tumor immune privilege.

    LENUS (Irish Health Repository)

    O'Connell, J

    2012-02-03

    Breast cancers have been shown to elicit tumor-specific immune responses. As in other types of cancer, the antitumor immune response fails to contain breast tumor growth, and a reduction in both the quantity and cytotoxic effectiveness of tumor-infiltrating lymphocytes (TILs) is associated with a poorer prognosis. Fas ligand (FasL) induces apoptotic death of activated lymphocytes that express its cell surface receptor, FasR (CD95\\/APO-1). FasL-mediated apoptosis of activated lymphocytes contributes to normal immune downregulation through its roles in tolerance acquisition, immune response termination, and maintenance of immune privilege in the eye, testis, and fetus. In this report, we demonstrate that breast carcinomas express FasL. Using in situ hybridization and immunohistochemistry, we show that breast tumors constitutively express FasL at both the mRNA and protein levels, respectively. FasL expression is prevalent in breast cancer: 100% of breast tumors (17 of 17) were found to express FasL, and expression occurred over more than 50% of the tumor area in all cases. By immunohistochemistry, FasR was found to be coexpressed with FasL throughout large areas of all the breast tumors. This suggests that the tumor cells had acquired intracellular defects in FasL-mediated apoptotic signaling. FasL and FasR expression were independent of tumor type or infiltrative capacity. FasL expressed by tumor cells has previously been shown to kill Fas-sensitive lymphoid cells in vitro and has been associated with apoptosis of TILs in vivo. We conclude that mammary carcinomas express FasL in vivo as a potential inhibitor of the antitumor immune response.

  7. Biokinetic of plutonium in human beings. Analysis and modification of ICRP 67 model; Biocinetica del plutonio nell'organismo umano. Analisi e modifica del modello ICRP 67

    Energy Technology Data Exchange (ETDEWEB)

    Luciani, A.; Castellani, C.M. [ENEA, Divisione Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche Ezio Clementel, Bologna (Italy)

    2001-07-01

    A preliminary research of the available data and empirical functions for the plutonium excretion after injection was carried out. The ICRP model presented in the Publication no. 67 was then analyzed comparing its predictions for the activity in urine and, at a lesser extent, in feces and blood, with the collected data and empirical curves. The model was modified and an optimized age-related compartmental model was developed. A new skeletal model recently developed was also introduced and age depending bone remodelling rates were assumed on the basis of the ICRP Publication 70. This model provides a better agreement with measured urinary excretion data than the current ICRP 67 model, avoiding unphysiological assumptions such as the transfer of activity from soft tissue to urinary bladder, that were part of the ICRP model. The new optimized model predictions of the activity in faeces and in blood after an injection are also closer to the available data than the ICRP 67 estimations. A good agreement with the partitioning factor of plutonium between skeleton and liver obtained from different autopsy studies was also observed. [Italian] E' stata effettuata preliminarmente una ricerca bibliografica dei dati e delle funzioni di escrezione del plutonio attualmente disponibili in letteratura. Sulla base dei risultati di tale ricerca e' stato verificato il modello proposto dall'ICRP nella Pubblicazione n. 67. Tale modello e' stato quindi modificato al fine non solo di avere una piu' realistica descrizione dei valori predetti per l'escrezione urinaria, ma anche di modellare la cinetica del plutonio evitando quelle assunzioni introdotte appositamente nel modello dell'ICRP per correggere le previsini del modello ma che mancano di una chiara spiegazione di carattere fisiologico. Esso fornisce valutazioni piu' realistiche anche per l'attivita' nelle feci e nel sangue. Il modello sviluppato comprende un modello scheletrico

  8. Report of 'the 2014 international forum on peaceful use of nuclear energy, nuclear non-proliferation and nuclear security. Future direction toward promoting non-proliferation and the ideal method of developing human resources using Centers of Excellence (COEs) following the new strategic energy plan'

    International Nuclear Information System (INIS)

    Yamaga, Chikanobu; Tomikawa, Hirofumi; Kobayashi, Naoki; Naoi, Yosuke; Oda, Tetsuzo; Mochiji, Toshiro

    2015-10-01

    The Japan Atomic Energy Agency (JAEA) held 'International Forum on Peaceful Use of Nuclear Energy, Nuclear Non-proliferation and Nuclear Security – Future direction toward promoting non-proliferation and the ideal method of developing human resources using Centers of Excellence (COEs) following the New Strategic Energy Plan -' on 3 December 2014, with the Japan Institute of International Affairs (JIIA) and School of Engineering, The University of Tokyo, and International Nuclear Research Center, Tokyo Institute of Technology as co-hosts. In the Forum, officials and experts from Japan, the United States explained their efforts regarding peaceful use of nuclear energy, nuclear non-proliferation and nuclear security. Discussion was made in two panels, entitled 'Effective and efficient measures to ensure nuclear non-proliferation based on domestic and foreign issues and the direction and role of technology development' and 'Roles of nuclear security COEs and future expectations'. In Panel Discussion 1, as the nuclear non-proliferation regime is facing various problems and challenges under current international circumstances, how to implement effective and efficient safeguards was discussed. In Panel Discussion 2, panelists discussed the following three points: 1. Current status of Nuclear Security Training and Support Centers and COEs, and Good Practice; 2. What these centers can do to enhance nuclear security (New role for COEs); 3. Regional cooperation in the Nuclear Security Training and Support Center (NSSC) and COEs in states, which the IAEA recommends establishing, and international cooperation and partnerships with international initiatives (New Role). Officials and experts from Japan, IAEA, the United States, France, Republic of Korea, and Indonesia participated in the panel and made contributions to active discussion. This report includes abstracts of keynote speeches, summaries of two panel discussions and materials of the

  9. Principals' Human Capital Development Practices for Enhancing Staff Personnel Administration in Secondary Schools in Oyo State, Nigeria

    Science.gov (United States)

    Chidi, Nnebedum; Victor, Akinfolarin Akinwale

    2017-01-01

    Unsatisfactory performance of secondary school students in external examinations in Oyo State seems to suggest lapses in principals' application of human capital development practices especially in the areas of training and mentoring of teachers to enhance instructional delivery. This unpleasant state of affair necessitated the researchers to…

  10. Aspects of the cosmological ''coincidence problem''

    Energy Technology Data Exchange (ETDEWEB)

    Velten, H.E.S.; Marttens, R.F. vom; Zimdahl, W. [Universidade Federal do Espirito Santo (UFES), Departamento de Fisica, Vitoria, Espirito Santo (Brazil)

    2014-11-15

    The observational fact that the present values of the densities of dark energy and dark matter are of the same order of magnitude, ρ{sub de0}/ρ{sub dm0} ∝ O(1), seems to indicate that we are currently living in a very special period of the cosmic history. Within the standard model, a density ratio of the order of one just at the present epoch can be seen as coincidental since it requires very special initial conditions in the early Universe. The corresponding ''why now'' question constitutes the cosmological ''coincidence problem''. According to the standard model the equality ρ{sub de} = ρ{sub dm} took place ''recently'' at a redshift z ∼ 0.55. The meaning of ''recently'' is, however, parameter dependent. In terms of the cosmic time the situation looks different. We discuss several aspects of the ''coincidence problem'', also in its relation to the cosmological constant problem, to issues of structure formation and to cosmic age considerations. (orig.)

  11. Biological effect and tumor risk of diagnostic x-rays. The ''war of the theories''; Biologische Wirkung und Tumorrisiko diagnostischer Roentgenstrahlen. Der ''Krieg der Modelle''

    Energy Technology Data Exchange (ETDEWEB)

    Selzer, E.; Hebar, A. [Medizinische Universitaet Wien, Abteilung fuer Strahlenbiologie, Klinik fuer Strahlentherapie, Wien (Austria)

    2012-10-15

    Since the introduction of ionizing radiation as a treatment and diagnostic tool in humans, scientists have been trying to estimate its side effects and potential health risks. There is now ample evidence for the principal existence of a direct relationship between higher doses and the risks of side effects. Most of the uncertainties lie in the field of low-dose effects especially with respect to the risk of cancer induction. Low-dose effects are usually of relevance in diagnostic medicine while high-dose radiation effects are typically observed after radiotherapeutic treatment for cancer or after nuclear accidents. The current state of the ''war of theories'' may be summarized as follows: one group of scientists and health regulatory officials favors the hypothesis that there is no threshold dose, i.e. the linear-no-threshold hypothesis (LNT) of radiation which can be regarded as safe. On the contrary, the critics of this hypothesis suggest that the risks of doses below 50 mSv are not measurable or even of clinical relevance and are not adequately described by a linear dose-response relationship. The aim of this article is to summarize the major unresolved issues in this field. Arguments are presented why the validity of the LNT model in the low-dose range should be regarded as at least inconsistent and is thus questionable. (orig.) [German] Seit der Einfuehrung ionisierender Strahlen als ein Mittel zur Behandlung und Diagnose beim Menschen haben Wissenschaftler versucht, ihre Nebenwirkungen und potenziellen Risiken fuer die Gesundheit einzuschaetzen. Es gibt nun ausreichende Evidenz fuer das grundsaetzliche Vorliegen einer direkten Beziehung zwischen hoeheren Dosen und Nebenwirkungsrisiken. Die meisten Unsicherheiten liegen auf dem Gebiet der Niedrigdosisforschung v. a. im Hinblick auf das Risiko der Induktion von Krebs. Niedrigdosiseffekte sind ueblicherweise von Bedeutung in der diagnostischen Medizin, waehrend Hochdosisbestrahlungseffekte

  12. Divergent systemic and local inflammatory response to hind limb demand ischemia in wild-type and ApoE-/- mice.

    Science.gov (United States)

    Crawford, Robert S; Albadawi, Hassan; Robaldo, Alessandro; Peck, Michael A; Abularrage, Christopher J; Yoo, Hyung-Jin; Lamuraglia, Glenn M; Watkins, Michael T

    2013-08-01

    We designed studies to determine whether the ApoE-/- phenotype modulates the local skeletal muscle and systemic inflammatory (plasma) responses to lower extremity demand ischemia. The ApoE-/- phenotype is an experimental model for atherosclerosis in humans. Aged female ApoE-/- and C57BL6 mice underwent femoral artery ligation, then were divided into sedentary and demand ischemia (exercise) groups on day 14. We assessed baseline and postexercise limb perfusion and hind limb function. On day 14, animals in the demand ischemia group underwent daily treadmill exercise through day 28. Sedentary mice were not exercised. On day 28, we harvested plasma and skeletal muscle from ischemic limbs from sedentary and exercised mice. We assayed muscle for angiogenic and proinflammatory proteins, markers of skeletal muscle regeneration, and evidence of skeletal muscle fiber maturation. Hind limb ischemia was similar in ApoE-/- and C57 mice before the onset of exercise. Under sedentary conditions, plasma vascular endothelial cell growth factor and interleukin-6, but not keratinocyte chemoattractant factor (KC) or macrophage inflammatory protein-2 (MIP-2), were higher in ApoE (P factor, KC, and MIP-2, but not IL-6, were lower in ApoE (P demand ischemia in the C57BL6 mice, compared with the ApoE-/- mice (P = 0.01). Demand limb ischemia in the ApoE-/- phenotype exacerbated the expression of select systemic cytokines in plasma and blunted indices of muscle regeneration. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. ApoE polymorphisms in narcolepsy

    Science.gov (United States)

    Gencik, Martin; Dahmen, Norbert; Wieczorek, Stefan; Kasten, Meike; Gencikova, Alexandra; Epplen, Jorg T

    2001-01-01

    Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset neuronal degeneration in Alzheimer disease and other neurodegenerative diseases as well. Methods To clarify whether the ApoE4 phenotype predisposes to narcolepsy or associates with an earlier disease onset, we have genotyped the ApoE gene in 103 patients with narcolepsy and 101 healthy controls. Results The frequency of the E4 allele of the ApoE gene was 11% in the patient and 15% in the control groups. Furthermore, the mean age of onset did not differ between the ApoE4+ and ApoE4- patient groups. Conclusion Our results exclude the ApoE4 allele as a major risk factor for narcolepsy. PMID:11560764

  14. ApoE polymorphisms in narcolepsy

    Directory of Open Access Journals (Sweden)

    Kasten Meike

    2001-08-01

    Full Text Available Summary Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset neuronal degeneration in Alzheimer disease and other neurodegenerative diseases as well. Methods To clarify whether the ApoE4 phenotype predisposes to narcolepsy or associates with an earlier disease onset, we have genotyped the ApoE gene in 103 patients with narcolepsy and 101 healthy controls. Results The frequency of the E4 allele of the ApoE gene was 11% in the patient and 15% in the control groups. Furthermore, the mean age of onset did not differ between the ApoE4+ and ApoE4- patient groups. Conclusion Our results exclude the ApoE4 allele as a major risk factor for narcolepsy.

  15. Case story for upgrading of a ''hot'' ESP; Modernisation d'un precipitateur electrostatique ''chaud''

    Energy Technology Data Exchange (ETDEWEB)

    Chidambaram, T.V.S; Christensen

    2001-06-01

    The 'Hot' Electrostatic Precipitator (ESP) equipped with COROMAX pulse system is a very attractive solution for dedusting of the 'Hot' exhausted gases from the cement kilns especially on cement plants, where good quality of water is not available on the site. Furthermore, the Electrostatic Precipitator is still the preferred solution in the cement plants for dedusting the cement kiln. It is favored because of its high degree of reliability, its low power consumption, and its low maintenance cost. (author)

  16. Switzerland as Europe's ''battery''. Wishful dream or reality?

    International Nuclear Information System (INIS)

    Kammer, Adrian; Zurmuehle, Damian; Salzmann, Michael; Baumgartner, Raphael; Mignone, Domenico

    2015-01-01

    There are plans for Swiss pumped hydrostorage systems to absorb large quantities of excess electricity from European wind and solar power generation. Model-based analyses have shown however that ''Europe's battery'', as Switzerland would like to see itself, will not be needed until the middle of this century. Even if all extension projects currently in progress should be completed, Switzerland will not have sufficient pump capacity or import capacity to absorb large amounts of excess electricity. Furthermore, the primary means of making storage capacity available for import electricity would be to reduce reservoir power plant capacity. In view of all this Switzerland's hopes for a role as a major European electricity storage provider appear somewhat exaggerated even in the long-term perspective.

  17. Twenty-ninth day: accommodating human needs and numbers to the Earth's resources. [ecological impacts of overpopulation

    Energy Technology Data Exchange (ETDEWEB)

    Brown, L.R.

    1978-01-01

    The global lily pond in which four billion of us live may already be half full. The author believes that UN projections showing world population continuing to grow until it reaches ten to sixteen billion is unrealistic. In this analysis of the four principal biological systems on which humanity depends - fisheries, forests, grasslands, and croplands - the author shows that the demands at current levels of population and per capita consumption often exceed the long-term carrying capacity. The effects of overfishing, deforestation, and overgrazing that are gradually undermining human life-support systems are documented. With energy shortages anticipated inthe early eighties and the projected downturn in world oil production in the early nineties, the world must quickly shift to renewable energy resources. These accommodations constitute an enormous challenge and suggest changes that will affect virtually every facet of human existence. The coming transformation will surely give rise to new social structures and to an economic system materially different from any we know today. Like other periods of convulsive change, it will put great stress on both individuals and institutions. 106 references, 17 figures, 18 tables.

  18. Effects of modern and ancient human activities on mercury in the environment in Xi'an area, Shannxi Province, P.R. China

    Energy Technology Data Exchange (ETDEWEB)

    Jin Yongqing; Wang Xiaojuan [Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Materials Science, Shaanxi Normal University, Xi' an 710062 (China); Department of Chemistry and Biology, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3 (Canada); Lu Julia [Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Materials Science, Shaanxi Normal University, Xi' an 710062 (China); Department of Chemistry and Biology, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3 (Canada)], E-mail: julialu@ryerson.ca; Zhang Chengxiao [Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Materials Science, Shaanxi Normal University, Xi' an 710062 (China)], E-mail: cxzhang@snnu.edu.cn; Duan Qingbo [Shaanxi Archaeology Institute, Xi' an 710054 (China)

    2008-05-15

    Samples of water, soil, sediment, and pomegranate were collected from Xi'an and the Qinshihuang Mausoleum in Shaanxi Province, China to assess the effects of human activities on mercury in the environment. The total mercury concentrations ranged from 3.9 to 992.7 ng L{sup -1} for the water samples, 40.6 to 2204.0 ng g{sup -1} for the soil samples, 14.2 to 376.7 ng g{sup -1} for the sediment samples, and 0.22 to 1.74 ng g{sup -1} for the pomegranates samples. The higher values in the water samples collected from the rivers closer to and downstream of the city resulted from wastewater discharges. The effects of the mercury buried in the Qinshihuang Mausoleum thousands of years ago on the environment were neither significant nor widespread. Immediate actions should be taken to stop the direct and continuous discharges of industrial and residential wastewaters to prevent mercury and other pollutants from accumulating and spreading in the area. - Urban activities are sources of mercury to the environment and the pomegranates grown over the burial mound of the Qinshihuang Mausoleum are not mercury-contaminated.

  19. Korea's 1-watt plan ''Standby Korea 2010''

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yungrae

    2010-09-15

    Korea announced standby power of all electronics shall be reduced to below 1W by 2010. Ministry of Knowledge Economy (MKE, Korean government) and Korea Energy Management Corporation (KEMCO) established ''Standby Korea 2010'' which is a roadmap to limit standby power below 1W by 2010. Korea implemented mandatory program over a relatively short period of time, incorporating the better elements from the more established national program and adding new initiatives, such as the threat of using mandatory warning label for products that fail to meet standby power targets.

  20. LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL

    Directory of Open Access Journals (Sweden)

    Koike Kazuhiko

    2011-08-01

    Full Text Available Abstract Background The physiological regulation of hepatic apoE gene has not been clarified, although the expression of apoE in adipocytes and macrophages has been known to be regulated by LXR. Methods and Results We investigated the effect of TO901317, a LXR agonist, on hepatic apoE production utilizing HepG2 cells cultured in spheroid form, known to be more differentiated than HepG2 cells in monolayer culture. Spheroid HepG2 cells were prepared in alginate-beads. The secretions of albumin, apoE and apoA-I from spheroid HepG2 cells were significantly increased compared to those from monolayer HepG2 cells, and these increases were accompanied by increased mRNA levels of apoE and apoA-I. Several nuclear receptors including LXRα also became abundant in nuclear fractions in spheroid HepG2 cells. Treatment with TO901317 significantly increased apoE protein secretion from spheroid HepG2 cells, which was also associated with the increased expression of apoE mRNA. Separation of the media with FPLC revealed that the production of apoE-rich large HDL particles were enhanced even at low concentration of TO901317, and at higher concentration of TO901317, production of VLDL particles increased as well. Conclusions LXR activation enhanced the expression of hepatic apoE, together with the alteration of lipoprotein particles produced from the differentiated hepatocyte-derived cells. HepG2 spheroids might serve as a good model of well-differentiated human hepatocytes for future investigations of hepatic lipid metabolism.

  1. Isolation and characterization of human apolipoprotein M-containing lipoproteins

    DEFF Research Database (Denmark)

    Christoffersen, Christina; Nielsen, Lars Bo; Axler, Olof

    2006-01-01

    Apolipoprotein M (apoM) is a novel apolipoprotein with unknown function. In this study, we established a method for isolating apoM-containing lipoproteins and studied their composition and the effect of apoM on HDL function. ApoM-containing lipoproteins were isolated from human plasma...... with immunoaffinity chromatography and compared with lipoproteins lacking apoM. The apoM-containing lipoproteins were predominantly of HDL size; approximately 5% of the total HDL population contained apoM. Mass spectrometry showed that the apoM-containing lipoproteins also contained apoJ, apoA-I, apoA-II, apoC-I, apo...

  2. ''When Cost Measures Contradict''

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P. M.

    2003-05-09

    When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy's costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure's ability to correctly rank policies from most beneficial to most harmful. This paper analyzes empirically these two properties of different costs measures as they pertain to assessing the costs of the carbon abatement policies, especially the Kyoto Protocol, under alternative assumptions about implementation.

  3. ''SMART'' MULTIFUNCTIONAL POLYMERS FOR ENHANCED OIL RECOVERY

    Energy Technology Data Exchange (ETDEWEB)

    Charles McCormick; Andrew Lowe

    2004-10-20

    Herein we report the aqueous polymerization of acrylamide using reversible addition fragmentation chain transfer (RAFT) polymerization to perform a comprehensive study on the polymerization of acrylamide. More specifically, the effect of polymerization conditions on the polymerization kinetics, molecular weight control, and blocking ability were examined. With this in mind, it was necessary to prepare ''A'' block (corona of the micelle) from a hydrophilic monomer. The responsive ''B'' block present in the core will be disclosed in the next two reports.

  4. First monitoring report ''The future of the power''; Erster Monitoring-Bericht ''Energie der Zukunft''

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-12-15

    The Federal Government has initiated the reconstruction of the energy supply towards a highly efficient and renewable energy systems using the energy concept from September, 2010, and using the energy political resolutions from June, 2011. The energy policy turnaround is ambitioned in its objectives as well as broadly defined. In order to consider the energy policy turnaround as well as the development of the energy market continuously, the Federal Government initiated the monitoring process ''Energy of the future'' with the aim to review regularly the implementation of the measures of the energy concepts as well as the progress in the goal achievement with a view on a secure, economical and environmentally compatible energy supply. The first monitoring report ''Energy of the future'' under consideration is the onset of this process. This report is an important basis for the current fact-based attendance of the energy policy turnaround.

  5. Perfluorinated carboxylic acids in human breast milk from Spain and estimation of infant's daily intake

    Energy Technology Data Exchange (ETDEWEB)

    Motas Guzmàn, Miguel [Área de Toxicología, Universidad de Murcia, Campus de Espinardo, 30100 Murcia (Spain); Clementini, Chiara [University of Siena, Department of Physical Sciences, Earth and Environment, Via Mattioli, 4, 53100 Siena (Italy); Pérez-Cárceles, Maria Dolores; Jiménez Rejón, Sandra [Department of Legal Medicine, School of Medicine, University of Murcia & Instituto Murciano de Investigacion Biomedica (IMIB), (IMIB-VIRGEN DE LA ARRIXACA), Murcia (Spain); Cascone, Aurora; Martellini, Tania [Department of Chemistry “Ugo Schiff”, via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze (Italy); Guerranti, Cristiana [University of Siena, Department of Physical Sciences, Earth and Environment, Via Mattioli, 4, 53100 Siena (Italy); Bioscience Research Center, Via Aurelia Vecchia 32, 58015 Orbetello, GR (Italy); Cincinelli, Alessandra, E-mail: acincinelli@unifi.it [Department of Chemistry “Ugo Schiff”, via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze (Italy)

    2016-02-15

    Human milk samples were collected from 67 mothers in 2014 at a Primary Care Centre in Murcia (Spain) and analyzed for perfluorinated carboxylic acids (PFCAs). Concentrations measured for perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA) and perfluorododecanoic acid (PFDoDA) ranged from < LOQ (< 10 ng/L) to 397 ng/L with a mean concentration of 66 ± 68 ng/L and a median of 29 ng/L. The presence of these compounds was revealed in 50 samples out of 67 analyzed. Influence of number of pregnancies and food habits on PFCAs concentrations was also investigated. Statistically significant differences in PFCA levels were found when the women were divided into maternal age classes and into the categories primiparae and multiparae. A greater transfer of PFC during breastfeeding by primiparous was evidenced and thus a higher exposure to these contaminants for the first child. Moreover, it was possible to hypothesize that the content of PFCs is in general correlated to the eating habits of donors and, in particular, with the fish consumption. Finally, PFOA daily intakes and risk index (RI) were estimated for the first six months of life and we found that ingestion rates of PFOA did not exceed the tolerable daily intake (TDI) recommended by the European Food Safety Authority (EFSA). - Graphical abstract: Figure SI 1. Concentrations (ng/L) of PFCs recovered in 67 samples of human breast milk. - Highlights: • Perfluorinated carboxylic acids were analyzed in a set of 67 breast milk samples collected from Spanish women. • PFOA appeared as the major contributor to the total perfluorinated carboxylic acids. • PFOA concentrations were significantly higher in milk of primiparous participants. • PFOA daily intake and risk index were estimated for the firsts six month of life.

  6. Perfluorinated carboxylic acids in human breast milk from Spain and estimation of infant&apos;s daily intake

    International Nuclear Information System (INIS)

    Motas Guzmàn, Miguel; Clementini, Chiara; Pérez-Cárceles, Maria Dolores; Jiménez Rejón, Sandra; Cascone, Aurora; Martellini, Tania; Guerranti, Cristiana; Cincinelli, Alessandra

    2016-01-01

    Human milk samples were collected from 67 mothers in 2014 at a Primary Care Centre in Murcia (Spain) and analyzed for perfluorinated carboxylic acids (PFCAs). Concentrations measured for perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA) and perfluorododecanoic acid (PFDoDA) ranged from < LOQ (< 10 ng/L) to 397 ng/L with a mean concentration of 66 ± 68 ng/L and a median of 29 ng/L. The presence of these compounds was revealed in 50 samples out of 67 analyzed. Influence of number of pregnancies and food habits on PFCAs concentrations was also investigated. Statistically significant differences in PFCA levels were found when the women were divided into maternal age classes and into the categories primiparae and multiparae. A greater transfer of PFC during breastfeeding by primiparous was evidenced and thus a higher exposure to these contaminants for the first child. Moreover, it was possible to hypothesize that the content of PFCs is in general correlated to the eating habits of donors and, in particular, with the fish consumption. Finally, PFOA daily intakes and risk index (RI) were estimated for the first six months of life and we found that ingestion rates of PFOA did not exceed the tolerable daily intake (TDI) recommended by the European Food Safety Authority (EFSA). - Graphical abstract: Figure SI 1. Concentrations (ng/L) of PFCs recovered in 67 samples of human breast milk. - Highlights: • Perfluorinated carboxylic acids were analyzed in a set of 67 breast milk samples collected from Spanish women. • PFOA appeared as the major contributor to the total perfluorinated carboxylic acids. • PFOA concentrations were significantly higher in milk of primiparous participants. • PFOA daily intake and risk index were estimated for the firsts six month of life.

  7. Mencius&apos; Educational Philosophy and Its Contemporary Relevance

    Science.gov (United States)

    Huang, Chun-chieh

    2014-01-01

    This article argues that Mencius&apos; education is "holistic education" that aims at igniting the "silent revolution" from within one&apos;s inner mind-heart to be unfolded in society, state, and the world. Mencius&apos; educational philosophy is based on his theory of human nature and his theory of self-cultivation. Mencius…

  8. Suppression of c-Myc is involved in multi-walled carbon nanotubes&apos; down-regulation of ATP-binding cassette transporters in human colon adenocarcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhaojing [Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan (China); Xu, Yonghong [Institute of Ophthalmological Research, Department of Ophthalmology, Renmin Hospital of Wuhan University, 430060 Wuhan (China); Meng, Xiangning [School of Materials and Metallurgy, Northeastern University, Shenyang 110819 (China); Watari, Fumio [Department of Biomedical, Dental Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586 (Japan); Liu, Hudan, E-mail: hudanliu@hust.edu.cn [Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan (China); Chen, Xiao, E-mail: mornsmile@yahoo.com [Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan (China)

    2015-01-01

    Over-expression of ATP-binding cassette (ABC) transporters, a large family of integral membrane proteins that decrease cellular drug uptake and accumulation by active extrusion, is one of the major causes of cancer multi-drug resistance (MDR) that frequently leads to failure of chemotherapy. Carbon nanotubes (CNTs)-based drug delivery devices hold great promise in enhancing the efficacy of cancer chemotherapy. However, CNTs&apos; effects on the ABC transporters remain under-investigated. In this study, we found that multiwalled carbon nanotubes (MWCNTs) reduced transport activity and expression of ABC transporters including ABCB1/Pgp and ABCC4/MRP4 in human colon adenocarcinoma Caco-2 cells. Proto-oncogene c-Myc, which directly regulates ABC gene expression, was concurrently decreased in MWCNT-treated cells and forced over-expression of c-Myc reversed MWCNTs&apos; inhibitory effects on ABCB1 and ABCC4 expression. MWCNT-cell membrane interaction and cell membrane oxidative damage were observed. However, antioxidants such as vitamin C, β-mecaptoethanol and dimethylthiourea failed to antagonize MWCNTs&apos; down-regulation of ABC transporters. These data suggest that MWCNTs may act on c-Myc, but not through oxidative stress, to down-regulate ABC transporter expression. Our findings thus shed light on CNTs&apos; novel cellular effects that may be utilized to develop CNTs-based drug delivery devices to overcome ABC transporter-mediated cancer chemoresistance.

  9. Study of environmental factors&apos; influence on the human health in the case of the Moscow population

    Energy Technology Data Exchange (ETDEWEB)

    Bykov, A. [International Inst. of Risk Research, Moscow (Russian Federation); Pronina, I. [Moscow State Univ. (Russian Federation)

    1999-12-01

    Although ambient air pollution is known to affect human, quantitative measure of the impact is quite uncertain. One of the most successful approaches to evaluate adverse health consequences caused by actual concentrations of pollutants in ambient air, is risk assessment. The quantitative values of lifetime risk units recommended by international and some national organizations are often used in assessing the health risk from different sources (chemical pollutants, radioactive exposure, electromagnetic fields etc.). Recommendations of the World Health Organisation and United States Environmental Protection Agency in the Integrated Risk Data Base were taken for a basis in calculating health risks caused by chemically polluted ambient air in Russian cities. We also used well established approaches for assessing health risks from the substances not clearly defined in terms of risk units in the mentioned recommendations. In all cases, expert values of risks have been averaged, and the uncertainty range reflects the differences in the risk recommendations and the inaccuracies in methods used for measuring air pollutants.

  10. Brain imaging and memory systems in humans: the contribution of PET methods; Imagerie cerebrale et systeme de memoire chez l&apos;homme: contribution de l&apos;analyse par TEP

    Energy Technology Data Exchange (ETDEWEB)

    Perani, D. [Institute of Neuroscience and Bioimaging CNR, Milan (Italy)

    1998-03-01

    The development of neuroimaging methods such as PET, has provided a new impulse to the study of the neural basis of cognitive functions, and has extended the field of inquiry from the analysis of the consequences of brain lesions to the functional investigations of brain activity, either in patients with selective neuropsychological deficits or in normal subjects engaged in cognitive tasks. Specific patterns of hypo-metabolism in neurological patients are associated with different profiles of memory deficits.[{sup 18}F]FDG PET studies have confirmed the association of episodic memory with the structures of Papez&apos;s circuit and have shown correlations between short-term and semantic memory and the language areas. The identification of anatomical-functional networks involved in specific components of memory function in normal subjects is the aim of several PET activation studies. The results are in agreement with &apos;neural network&apos; models of the neural basis of memory, as complex functions subserved by multiple interconnected cortical and subcortical structures. (author)

  11. &apos;&apos;Die Dependance&apos;&apos; - Logistic center of the fair at Francfort; &apos;&apos;Die Dependance&apos;&apos; - Das Logistikzentrum der Messe Frankfurt

    Energy Technology Data Exchange (ETDEWEB)

    Klein, W.; Fleischer, J. [Brendel Ingenieure, Frankfurt/Main (Germany); Hummel, D. [FH Zwickau (Germany)

    2006-07-01

    In early November 2004, the logistic center &apos;&apos;Die Dependance&apos;&apos; was commissioned after a construction time of 21 months. It is the second building (after Hall 3) designed by London&apos;s star architect Nicholas Grimshow for the Frankfurt Fair. The new building will house the fairground managers and the Accente Gastronomie Service GmbH. Accente is a modern caterer for the fairground halls, Its kitchen in the new building is big enough for preparing up to 10,000 meals every day. (orig.)

  12. Characterization of lipoproteins in human and canine cerebrospinal fluid (CSF)

    International Nuclear Information System (INIS)

    Pitas, R.E.; Weisgraber, K.H.; Boyles, J.K.; Lee, S.; Mahley, R.W.

    1986-01-01

    Previously the authors demonstrated that rat brain astrocytes in vitro synthesize and secrete apo-E and possess apo-B,E(LDL) receptors. The apo-E secreted by astrocytes and apo-E in rat brain extracts differed from serum apo-E in two respects. Brain apo-E had a higher apparent molecular weight and a higher percentage of more acidic isoforms. To characterize further the apo-E within the central nervous system, apo-E in human and canine CSF was investigated. Compared to plasma apo-E, CSF apo-E had a higher apparent M/sub r/ and a higher percentage of acidic isoforms which were sialylated, as shown by neuraminidase digestion. The apo-E in human CSF was approx.5-10% of the plasma level. In CSF 60-80% of the apo-E was in lipoproteins with d = 1.09-1.15. The remainder of the apo-E was in the d > 1.21 fraction. Human CSF lipoproteins were primarily spherical (110-190 A) while canine CSF lipoproteins were a mixture of discs (205 x 65 A) while canine CSF lipoproteins were a mixture of discs (205 x 65 A) and spheres (100-150 A). The CSF also contained apo-AI in the d = 1.09-1.15 g/ml fraction. Human CSF lipoproteins containing both apo-E and apo-AI were isolated on an anti-apo-E affinity column, suggesting that apo-E and AI occurred in the same particles. The CSF apo-E-containing lipoproteins competed for binding of 125 I-LDL to the apo-B,E(LDL) receptor. There was no detectable apo-B in CSF. These data suggest that CSF lipoproteins might transport lipid and regulate lipid homeostasis within the brain

  13. 3&apos;,8&apos;&apos;-biisokaempferide, a cytotoxic biflavonoid and other chemical constituents of Nanuza plicata (Velloziaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Meri Emili F.; Silva, Marcelo Sobral da; Barbosa Filho, Jose Maria; Castello-Branco, Marianna Vieira S.; Agra, Maria de Fatima; Tavares, Josean Fechine, E-mail: marcelosobral@ltf.ufpb.b [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil). Lab. de Tecnologia Farmaceutica; Schindler, Elisabete; El-Bacha, Ramon dos Santos [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Inst. de Ciencias da Saude. Lab. de Neuroquimica e Biologia Celular

    2010-07-01

    A novel biflavonoid, named 3&apos;,8&apos;&apos;-biisokaempferide (1), along with the known compounds amentoflavone (2), patagonic acid (3), (4aR,5S,6R,8aR)-5-[2-(2,5-Dihydro-5-methoxy-2-oxofuran- 3-yl)ethyl]-3,4,4a,5,6,7,8,8a-octahydro-5,6,8a- trimethylnaphthalene-1-carboxylic acid (4), 5-caffeoylquinic acid methyl ester (5), 3,5-di-caffeoylquinic acid (6) and luteolin (7), were isolated of the leaves from Nanuza plicata. The compounds 3, 4, 5 and 6 are reported for the first time in Velloziaceae. The structures of the compounds were elucidated on the basis of spectroscopic methods, especially NMR and MS analyses. The cytotoxicity of 3&apos;,8&apos;&apos;-biisokaempferide was studied in cultures of human glioblastoma GL-15 cells. The effective concentration, which killed 50 % of cells after 72 h was 36.5 {mu}mol L{sup -1}. Changes in cellular morphology, including retraction and degradation of cytoplasm, were observed when cells were treated with concentrations from 20 {mu}mol L-1 of 3&apos;,8&apos;&apos;-biisokaempferide for 72 h. (author)

  14. Reflection group on &apos;Expert Culture&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Eggermont, G

    2000-07-01

    As part of SCK-CEN&apos;s social sciences and humanities programme, a reflection group on &apos;Expert Culture&apos; was established. The objectives of the reflection group are: (1) to clarify the role of SCK-CEN experts; (2) to clarify the new role of expertise in the evolving context of risk society; (3) to confront external views and internal SCK-CEN experiences on expert culture; (4) to improve trust building of experts and credibility of SCK-CEN as a nuclear actor in society; (5) to develop a draft for a deontological code; (6) to integrate the approach in training on assertivity and communication; (7) to create an output for a topical day on the subject of expert culture. The programme, achievements and perspectives of the refection group are summarised.

  15. Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE-/- mice with or without diabetes

    DEFF Research Database (Denmark)

    Hanssen, Nordin M J; Brouwers, Olaf; Gijbels, Marion J

    2014-01-01

    are higher in rupture-prone plaques. We here investigated whether overexpression of human GLO1 in ApoE(-/-) mice could reduce the development of atherosclerosis. METHODS AND RESULTS: We crossed C57BL/6 ApoE(-/-) mice with C57BL/6 GLO1 overexpressing mice (huGLO1(+/-)) to generate ApoE(-/-) (n = 16) and Apo......E(-/-) huGLO1(+/-) (n = 20) mice. To induce diabetes, we injected a subset with streptozotocin (STZ) to generate diabetic ApoE(-/-) (n = 8) and ApoE(-/-) huGLO1(+/-) (n = 13) mice. All mice were fed chow and sacrificed at 25 weeks of age. The GLO1 activity was three-fold increased in huGLO1(+/-) aorta......, but aortic root lesion size and phenotype did not differ between mice with and without huGLO1(+/-) overexpression. We detected no differences in gene expression in aortic arches, in AGE levels and cytokines, in circulating cells, and endothelial function between ApoE(-/-) mice with and without huGLO1...

  16. Flux quantization in &apos;autistic&apos; magnets

    Energy Technology Data Exchange (ETDEWEB)

    Costa de Beauregard, O.; Vigoureux, J.M.

    1974-03-15

    The Dirac electron theory for the evanescent wave surrounding an infinitely long cylindrical magnet with zero surface polarization and the requirement of the single valuedness of this wave are used to show that the magnetic flux is quantized in units h/2e emu. The same quantization is shown for a general &apos;'autistic'&apos; magnet (i.e. magnet completely trapping its flux), thus establishing complete external equivalence of the &apos;'autistic'&apos; magnet with the &apos;&apos;perfect solenoid&apos;&apos;. An experimental test of the predicted quantization is suggested.

  17. Energy and the new class. [Assault of &apos;&apos;new breed&apos;&apos; of American on established institutions

    Energy Technology Data Exchange (ETDEWEB)

    King, L.

    1979-03-14

    The bounty of the US is taken for granted by its population. Nowhere is this misvaluation of a society and its benefits more evident than in the energy industries. But energy represents a tool by which society can be shaped; a device by which the standared of living and the very nature of the national lifestyle can be controlled, modified, amplified, or reduced. Two examples examined to show how energy shapes social order and human life are the women&apos;s movement and the desire to live in the Sunbelt. Five phenomena are then examined to point out the desire to restrain the nation&apos;s rampant pursuit of a higher standard of living, as opposed to the more subjective and seemingly more desirable goal of a better quality of life: the civil rights movement; the environmental movement; the Vietnam War; the Watergate scandal; and the assumption that prosperity at today&apos;s level is irreducible, concrete, and not subject to diminution. The &apos;&apos;new class&apos;&apos; is essentially made up of those educated in the liberal arts, divorced from an understanding of the mechanics of free-enterprise institutions and of the sicences. The antagonistic view of the new class of corporations and its assault on established institutions are noted. Energy companies are frustrated in telling their story, but the story that must be told is not the story of how excellently the energy sector has performed, but the story of how a new breed of Americans is seeking to remake America in its own image without the rest being aware of what is going on. (MCW)

  18. Radiological assessment of skull base changes in children with syndromic craniosynostosis: role of &apos;'minor'&apos; sutures

    Energy Technology Data Exchange (ETDEWEB)

    Calandrelli, Rosalinda; D' Apolito, Gabriella; Gaudino, Simona; Stefanetti, Mariangela; Colosimo, Cesare [Universita Cattolica Sacro Cuore, Institute of Radiology, Rome (Italy); Massimi, Luca; Di Rocco, Concezio [Universita Cattolica Sacro Cuore, Institute of Neurosurgery, Rome (Italy)

    2014-10-15

    This study aims to identify the premature synostosis of &apos;'major'&apos; and &apos;'minor'&apos; sutures of the four &apos;&apos;sutural arches&apos;&apos; of the skull and to perform a morphometric analysis in children with syndromic craniosynostosis in order to evaluate changes in the skull base linked with premature suture synostosis. We reviewed multiplanar high-resolution CT images, implemented with 3D reconstructions, from 18 patients with complex syndromic craniosynostosis and compared them with 18 age-matched healthy subjects. We assessed the calvarial sutures and their extension to the skull base, and then we correlated specific types of synostosis with the size, shape and symmetry of the cranial fossae. We found a marked asymmetry of the skull base growth in all patients. The synostotic involvement around the coronal ring caused a reduction in the growth of the anterior and middle fossae. The size of the posterior cranial fossa was related not only to &apos;'major'&apos; but also to &apos;'minor'&apos; suture synostosis of the lambdoid and parieto-squamosal arches. Changes in the skull base and craniofacial axis symmetry are due to structural and functional relationships between &apos;'major'&apos; and &apos;'minor'&apos; skull sutures, suggesting a structural and functional relationship between the neurocranium and basicranium. The early recognition of prematurely closed skull base sutures may help clinicians and neurosurgeons to establish correct therapeutic approaches. (orig.)

  19. The influence of ApoE genotype on the lipid profile and lipoproteins ...

    African Journals Online (AJOL)

    The influence of ApoE genotype on the lipid profile and lipoproteins during normal pregnancy in a Southern African population. Donald Moshen Tanyanyiwa1,2, Adrian David Marais3, Pamela Byrnes3, Sheena Jones3. 1. Division of Human Genetics, Department of Pathology and Institute of Infectious Disease and ...

  20. &apos;&apos;Social capitalism&apos;&apos; in renewable energy generation: China and California comparisons

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Woodrow W. II.; Li, Xing [Clark Strategic Partners, PO Box 17975, Beverly Hills, CA 90210 (United States)

    2010-03-15

    With a population of over 1.3 billion people, demand for renewable energy is expected to grow to a USD $12 billion market in the near term. Under Renewable Energy Law (REL) in February 2005 in the People&apos;s Republic of China (PRC) passed by the National Congress, renewable energy projects will be able to receive a range of financial incentives starting in 2006, which will more than double the PRC current renewable energy generation from 7% to 15% by 2020. Most of the increase will be in hydroelectric generated power. Nonetheless, the nation and especially the provinces are moving rapidly to develop a wide range of renewable energy generation including solar, wind, geothermal and run of the river. Because China practices &apos;&apos;social capitalism&apos;&apos; as expressed in it&apos;s recurrent Five Year National Plans since 1999, the national government and all the provinces have programs, unlike many western and industrialized nations, to &apos;'plan'&apos; and provide for infrastructures. This paper concerns only the energy infrastructure sector and renewable energy generation in particular. The planning process includes financial incentives and investments which are a major part of the Chinese law focused on &apos;&apos;encouraging foreign investment industries&apos;&apos;. The key part of the law is to guarantee long-term power purchase agreements with state owned and controlled &apos;'utilities'&apos;. In short, China may have gotten the economics of the energy sector correct in its concern for planning and finance. The paper develops these energy infrastructure ideas along with the legal and financial requirements as &apos;'lessons'&apos; learned from the USA and especially California. These lessons now apply to China and allow it to learn from the American mistakes. Empirical data will be drawn from work done in China that examine the renewable energy generation and infrastructures and hence allow the RPC and its

  1. Quantitation of species differences in albumin–ligand interactions for bovine, human and rat serum albumins using fluorescence spectroscopy: A test case with some Sudlow&apos;s site I ligands

    Energy Technology Data Exchange (ETDEWEB)

    Poór, Miklós [Institute of Laboratory Medicine, University of Pécs, Ifjúság u. 13, Pécs H-7624 (Hungary); Li, Yin; Matisz, Gergely [Department of General and Physical Chemistry, University of Pécs, Pécs H-7624 (Hungary); János Szentágothai Research Center, Pécs H-7624 (Hungary); Kiss, László [Department of General and Physical Chemistry, University of Pécs, Pécs H-7624 (Hungary); Kunsági-Máté, Sándor [Department of General and Physical Chemistry, University of Pécs, Pécs H-7624 (Hungary); János Szentágothai Research Center, Pécs H-7624 (Hungary); Kőszegi, Tamás, E-mail: koszegit@freemail.hu [Institute of Laboratory Medicine, University of Pécs, Ifjúság u. 13, Pécs H-7624 (Hungary)

    2014-01-15

    Albumin, the most abundant plasma protein is an approximately 67 kDa sized water-soluble macromolecule. Since several drugs and xenobiotics circulate in the blood at least partially in albumin-bound form, albumin plays a key role in the pharmacokinetics/toxicokinetics of these chemicals. Most of the drugs and xenobiotics are Sudlow&apos;s site I ligands. In numerous studies, bovine serum albumin (BSA) is used for modeling albumin–ligand interactions and the results are extrapolated to human serum albumin (HSA). Furthermore, only limited information is available related to albumin–ligand interactions of different albumin species. Therefore, in our study, we have focused on the quantification of differences between bovine, human and rat serum albumin (RSA) using four Sudlow&apos;s site I ligands (luteolin, ochratoxin A, phenylbutazone and warfarin). Interactions were analyzed by fluorescence spectroscopy. Stability constants as well as competing capacities of the ligands were determined, and thermodynamic study was also performed. Our results highlight that there could be major differences between BSA, HSA and RSA in their ligand binding properties. Based on our observations we emphasize that in molecular aspects BSA behaves considerably differently from HSA or from albumins of other species therefore, it is strongly recommended to apply at least some confirmatory measurements when data obtained from other species are attempted to be extrapolated to HSA. -- Highlights: • Albumin–ligand interactions of human, bovine and rat albumins were studied. • Four Sudlow&apos;s site I ligands were tested by fluorescence spectroscopy. • Substantial differences were found in stability constants among albumin complexes. • Competing capacity of ligands showed major differences in the studied species. • Data obtained for BSA cannot be directly extrapolated to human albumin.

  2. Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III.

    Science.gov (United States)

    Ooi, Esther M; Chan, Dick C; Hodson, Leanne; Adiels, Martin; Boren, Jan; Karpe, Fredrik; Fielding, Barbara A; Watts, Gerald F; Barrett, P Hugh R

    2016-08-01

    Experimental data suggest that apolipoprotein (apo) C-II and C-III regulate triglyceride-rich lipoprotein (TRL) metabolism, but there are limited studies in humans. We investigated the metabolic associations of TRLs with apoC-II and apoC-III concentrations and kinetics in women. The kinetics of plasma apoC-II, apoC-III and very low-density lipoprotein (VLDL) apoB-100 and triglycerides were measured in the postabsorptive state using stable isotopic techniques and compartmental modelling in 60 women with wide-ranging body mass index (19·5-32·9 kg/m(2) ). Plasma apoC-II and apoC-III concentrations were positively associated with the concentrations of plasma triglycerides, VLDL1 - and VLDL2 -apoB-100 and triglyceride (all P triglyceride concentration and VLDL1 triglyceride PR, while apoC-II fractional catabolic rate (FCR) was positively associated with VLDL1 triglyceride FCR (all P triglyceride kinetics. ApoC-III PR, but not FCR, was positively associated with VLDL1 triglyceride, and VLDL2 -apoB-100 and triglyceride concentrations (all P triglyceride kinetics. In multivariable analysis, including homoeostasis model assessment score, menopausal status and obesity, apoC-II concentration was significantly associated with plasma triglyceride, VLDL1 -apoB-100 and VLDL1 triglyceride concentrations and PR. Using the same multivariable analysis, apoC-III was significantly associated with plasma triglyceride and VLDL1 - and VLDL2 -apoB-100 and triglyceride concentrations and FCR. In women, plasma apoC-II and apoC-III concentrations are regulated by their respective PR and are significant, independent determinants of the kinetics and plasma concentrations of TRLs. © 2016 Stichting European Society for Clinical Investigation Journal Foundation.

  3. &apos;Carbon-Money Exchange&apos; to contain global warming and deforestation

    Energy Technology Data Exchange (ETDEWEB)

    Nagase, Kozo E-mail: nagase@de.mbn.or.jp

    2005-07-01

    This paper builds a basic theory of &apos;Carbon-Money Exchange&apos; in which carbon as currency in nature&apos;s household (ecosystems) and money as currency in humankind&apos;s household (economy) are exchanged just like in a foreign exchange. The simple chemical equation below makes it possible (CO{sub 2}{yields}C+O{sub 2}=C+O{sub 2}{yields}CO{sub 2}). The left-hand side represents the work of plants to remove atmospheric CO{sub 2}. The right-hand side represents the work of humans as fossil fuel consumers to produce it. The exchange of the two currencies is possible by copying the fossil fuel market. The paper concludes that this new exchange can automatically contain global warming and deforestation, replacing onerous emissions trading. Moreover, it could revolutionize the conventional economy, creating counter-capitalism, or &apos;carbonism&apos;.

  4. Report of working committee 4 &apos;&apos;transmission of gases&apos;&apos;; Rapport de la commission 4 &apos;&apos;transport des gaz&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Volskij, E.

    2000-07-01

    Report of the WOC 4 Transmission contains the results of works carried out during 1998-2000 by the Committee members and the three study groups. The most important is: - review of actual situation and prospects for the gas pipeline transmission system development; - report of SG-4.1 &apos;Pipeline Ageing and Rehabilitation&apos;, including analysis of pipeline steels, welding and insulation, methods of rehabilitation, the program of pipeline reconstruction; - report of SG-4.2 &apos;Emission monitoring&apos; including appraisal of gas losses and methods of lowering of methane and other emissions of the gas units in different countries; - report of SG-4.3 &apos;Pipelines Integrity Management and Safety&apos; including basic information on gas pipeline failure intensity, key elements of the Integrity Management System of the gas transmission, methods of risk evaluation and the effectiveness of the approach. (authors)

  5. &apos;&apos;House in park&apos;&apos; gold plated. Subsequent certification for the new office building; &apos;&apos;Haus im Park&apos;&apos; vergoldet. Nachtraegliche LEED-Zertifizierung fuer neues Buerogebaeude

    Energy Technology Data Exchange (ETDEWEB)

    Herzog, Kati; Wildhack, Alice [Bilfinger Berger AG, Mannheim (Germany). Abt. Nachhaltigkeit/Energieeffizienz

    2011-07-01

    In March 2011, the &apos;&apos;house in park&apos;&apos; received the signet LEED {sup registered} of the U.S. Green Building Council (Washington, North Carolina, U.S.A.) in &apos;'gold'&apos;. In general, it is the second German project that was awarded with &apos;'gold'&apos; in the certification version &apos;&apos;New Construction, version 2009&apos;&apos;. The special challenge: In the planning phase, no aspects relevant to planning and execution with regard to LEED were implemented. In total there are 15 LEED-certified buildings actually in Germany (worldwide: 7,894). 115 Projects are registered (worldwide: 23,238). The trend is increasing, both nationally as well as internationally.

  6. Online trapping and enrichment ultra performance liquid chromatography-tandem mass spectrometry method for sensitive measurement of &apos;arginine-asymmetric dimethylarginine cycle&apos; biomarkers in human exhaled breath condensate

    Energy Technology Data Exchange (ETDEWEB)

    Di Gangi, Iole Maria, E-mail: giordano@pediatria.unipd.it [Chromatography and Mass Spectrometry Laboratory, Department of Women' s and Children' s Health, University of Padova (Italy); Pirillo, Paola [Chromatography and Mass Spectrometry Laboratory, Department of Women' s and Children' s Health, University of Padova (Italy); Carraro, Silvia [Unit of Allergy and Respiratory Diseases, Department of Women' s and Children' s Health, University of Padova (Italy); Gucciardi, Antonina; Naturale, Mauro [Chromatography and Mass Spectrometry Laboratory, Department of Women' s and Children' s Health, University of Padova (Italy); Baraldi, Eugenio [Unit of Allergy and Respiratory Diseases, Department of Women' s and Children' s Health, University of Padova (Italy); Giordano, Giuseppe [Chromatography and Mass Spectrometry Laboratory, Department of Women' s and Children' s Health, University of Padova (Italy)

    2012-11-19

    Highlights: Black-Right-Pointing-Pointer Simultaneous quantification of &apos;arginine-ADMA cycle&apos; metabolites developed in EBC. Black-Right-Pointing-Pointer EBC is a non-invasive matrix highly useful in patients with respiratory diseases. Black-Right-Pointing-Pointer Method, fast, precise and accurate, is suitable in the pediatric clinical studies. Black-Right-Pointing-Pointer Sensitivity is increased using on-line trapping and enrichment-UPLC-MS/MS method. Black-Right-Pointing-Pointer EBC measurements in asthmatic adolescents confirm that ADMA is increased in asthma. - Abstract: Background: Exhaled breath condensate (EBC) is a biofluid collected non invasively that, enabling the measurement of several biomarkers, has proven useful in the study of airway inflammatory diseases, including asthma, COPD and cystic fibrosis. To the best of our knowledge, there is no previous report of any analytical method to detect ADMA in EBC. Objectives: Aim of this work was to develop an online sample trapping and enrichment system, coupled with an UPLC-MS/MS method, for simultaneous quantification of seven metabolites related to &apos;Arginine-ADMA cycle&apos;, using the isotopic dilution. Methods: Butylated EBC samples were trapped in an online cartridge, washed before and after each injection with cleanup solution to remove matrix components and switched inline into the high pressure analytical column. Multiple reaction monitoring in positive mode was used for analyte quantification by tandem mass spectrometry. Results: Validation studies were performed in EBC to examine accuracy, precision and robustness of the method. For each compound, the calibration curves showed a coefficient of correlation (r{sup 2}) greater than 0.992. Accuracy (%Bias) was <3% except for NMMA and H-Arg (<20%), intra- and inter-assay precision (expressed as CV%) were within {+-}20% and recovery ranged from 97.1 to 102.8% for all analytes. Inter-day variability analysis on 20 EBC of adult subjects did

  7. Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer’s Disease Patients Carrying the APOE Epsilon 4 Allele

    Directory of Open Access Journals (Sweden)

    Alen Zollo

    2017-01-01

    Full Text Available Alzheimer’s disease (AD is the most common form of dementia in the elderly; important risk factors are old age and inheritance of the apolipoprotein E4 (APOE4 allele. Changes in amyloid precursor protein (APP binding, trafficking, and sorting may be important AD causative factors. Secretase-mediated APP cleavage produces neurotoxic amyloid-beta (Aβ peptides, which form lethal deposits in the brain. In vivo and in vitro studies have implicated sortilin-related receptor (SORL1 as an important factor in APP trafficking and processing. Recent in vitro evidence has associated the APOE4 allele and alterations in the SORL1 pathway with AD development and progression. Here, we analyzed SORL1 expression in neural stem cells (NSCs from AD patients carrying null, one, or two copies of the APOE4 allele. We show reduced SORL1 expression only in NSCs of a patient carrying two copies of APOE4 allele with increased Aβ/SORL1 localization along the degenerated neurites. Interestingly, SORL1 binding to APP was largely compromised; this could be almost completely reversed by γ-secretase (but not β-secretase inhibitor treatment. These findings may yield new insights into the complex interplay of SORL1 and AD pathology and point to NSCs as a valuable tool to address unsolved AD-related questions in vitro.

  8. Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

    DEFF Research Database (Denmark)

    Soerensen, Mette; Dato, Serena; Tan, Qihua

    2013-01-01

    -110) and 1,104 middle-aged Germans. rs769449 was in modest linkage equilibrium (R (2)=0.55) with rs429358 of the APOE-epsilon4 haplotype and adjusting for rs429358 eliminated the association of rs769449, indicating that the association likely reflects the well-known effect of rs429358. Gene-based analysis...

  9. Earth in the balance. Ecology and the human spirit; Urgence Planete Terre. L&apos;esprit humain face a la crise ecologique

    Energy Technology Data Exchange (ETDEWEB)

    Al Gore

    2007-07-01

    This book is the translation of the original American edition &apos;earth in the balance&apos;. When Earth in the Balance first came out, it caused quite a stir and for good reason. It convincingly makes the case that a crisis of epidemic proportions is nearly upon us and that if the world does not get its act together soon and agree to some kind of &apos;Global Marshall Plan&apos; to protect the environment, we&apos;re all up a polluted creek without a paddle. Myriad plagues are upon us, but the worst include the loss of biodiversity, the depletion of the ozone layer, the slash-and-burn destruction of rain forests, and the onset of global warming. None of this is new, of course, nor was it new in 1992. But most environmentalists will still get a giddy feeling reading such a call to action as written by a prominent politician. The book is arranged into three sections: the first describes the plagues; the second looks at how we got ourselves into this mess; and the final chapters present ways out. Gore gets his points across in a serviceable way, though he could have benefited from a firmer editor&apos;s hand; at times the analogies are arcane and the pacing is odd kind of like a Gore speech that climaxes at weird points and then sinks just as the audience is about to clap. Still, at the end you understand what&apos;s been said. Gore believes that if we apply some American ingenuity, the twin engines of democracy and capitalism can be rigged to help us stabilize world population growth, spread social justice, boost education levels, create environmentally appropriate technologies, and negotiate international agreements to bring us back from the brink. For example, a worldwide shift to clean, renewable energy sources would create huge economic opportunities for companies large and small to design, build, and maintain solar panels, wind turbines, fuel cells, and other eco friendly innovations.

  10. Serum 3,3&apos;-L-diiodothyronine, a direct radioimmunoassay in human serum: method and clinical results. [/sup 125/I tracer technique

    Energy Technology Data Exchange (ETDEWEB)

    Burger, A.; Sakoloff, C.

    1977-09-01

    A specific radioimmunoassay for 3,3&apos;-diiodothyronine (T/sub 2/) is described which is capable of detecting as little as 1.3 ng/dl. The antiserum recognizes mainly T/sub 2/; biliary conjugates of T/sub 2/ bind slightly to the antibody. The intraassay and interassay coefficients of variation were, respectively, 5.7% and 13.1%. T/sub 2/ was detected in the serum of hypothyroid patients treated with triiodothyronine (T/sub 3/) and in euthyroid subjects treated with reverse triiodothyronine (rT/sub 3/). These results suggest that both T/sub 3/ and rT/sub 3/ are deiodinated to T/sub 2/. Serum concentrations of T/sub 2/ in normal subjects decreased with age. Between 20 and 40 years the mean concentration was 4.3 +- 2.0 ng/dl (2 SD), between 41 and 60 years it varied from 1.9 to 5.8 ng/dl (3.8 +- 0.3 ng/dl, SE) and in elderly subjects have 60 years concentrations varied from unmeasurable to 4 ng/dl (2.9 +- 0.4 ng/dl, SE). Low serum T/sub 2/ concentrations were found in anorexia nervosa (2.5 +- 0.3 ng/dl, SE). In hypothyroidism the serum concentrations were low or unmeasurable. As most of the hypothyroid subjects were elderly their serum T/sub 2/ concentrations overlapped with the low values found in the elderly euthyroid subjects. In classical hyperthyroidism serum T/sub 2/ concentrations were greatly increased (3.3 to 31 ng/dl (11.8 +- 2.7 ng/dl, SE) but in &apos;&apos;T/sub 3/ toxicosis&apos;&apos; the concentrations were only modestly increased (2.4 to 8.8 ng/dl, 5.2 +- 0.8 ng/dl, SE).

  11. Pumped storage project &apos;&apos;Energiespeicher Riedl&apos;&apos;; Das Projekt Energiespeicher Riedl

    Energy Technology Data Exchange (ETDEWEB)

    Mayr, Dominik [Verbund Hydro Power AG, Vienna (Austria); Schmauss, Juergen [Regierung von Niederbayern, Landshut (Germany); Neuwerth, Sabine [Grenzkraftwerke GmbH, Simbach am Inn (Germany)

    2012-07-01

    The &apos;&apos;Donaukraftwerk Jochenstein AG&apos;&apos; (DKJ) plans at the river power plant Jochenstein on the Danube in the district of Passau, Bavaria, South-east Germany, the construction of a modern pumped-storage hydropower plant with a capacity of 300 megawatts, the pumped storage &apos;&apos;Energiespeicher Riedl&apos;&apos;. The planned plant is a regionally significant project by the Regional Planning act. Therefore, the DKJ as applicant submitted the documents for the regional planning proceedings to the Government of Lower Bavaria, which completed the process with the positive regional planning assessment under provisos on 01.08.2011, which led to an optimization of the project layout. (orig.)

  12. Post-Copenhagen: the &apos;new&apos; math, legal &apos;additionality&apos; and climate warming

    Energy Technology Data Exchange (ETDEWEB)

    Ferrey, Steven

    2010-05-15

    Control of carbon emissions to the atmosphere is the environmental issue of this decade - perhaps of this entire generation. Its importance has been equated to the survival of the planet. It may all come down to the novel legal concept that sounds like second-grade math: &apos;'additionality.'&apos; However, it is the &apos;'new'&apos; math. (author)

  13. Comparison of PCDD/Fs levels and profiles in leachates from &apos;'new'&apos; and &apos;'old'&apos; municipal landfills

    Energy Technology Data Exchange (ETDEWEB)

    Dudzinska, M.; Czerwinski, J.; Rut, B. [Lublin Univ. of Technology (Poland)

    2004-09-15

    Although the presence of PCDD/Fs in landfill leachates has been confirmed, not many experiments have been undertaken in this area, probably because of a very low solubility of PCDD/Fs in water. Modern, properly designed landfills should secure (seal) all deposited wastes and possible leakings within the damp. Leachates are collected and treated on the site or transported to a wastewater treatment plant, so they should not cause a release of any pollutants into the soil or groundwater. But PCDD/Fs as well as a number of chlorinated compounds, which may act as precursors of dioxins under aerobic or anaerobic conditions have been identified as trace contaminants in municipal wastes. The formation of dioxins during municipal waste deposition has not been studied, contrary to the formation of OCDD from precursors under aerobic conditions during composting of waste or treatment of sewage sludge5. Some information about the possible dioxin formation during landfilling might be obtained from the comparison of PCDD/F levels in the leachates from &apos;&apos;old - closed&apos;&apos; and &apos;'new'&apos; sites.

  14. XVII International Scientific Conference &apos;&apos;RESHETNEV READINGS&apos;&apos;

    International Nuclear Information System (INIS)

    2015-01-01

    The International Scientific Conference &apos;RESHETNEV READINGS&apos; is dedicated to the memory of Mikhail Reshetnev, an outstanding scientist, chief-constructor of space-rocket systems and communication satellites. The current volume represents selected proceedings of the main conference materials which were published by XVII International Scientific Conference &apos;RESHETNEV READINGS&apos; held on November 12 – 14, 2013. Plenary sessions, round tables and forums will be attended by famous scientists, developers and designers representing the space technology sector, as well as professionals and experts in the IT industry. A number of outstanding academic figures expressed their interest in an event of such a level including Jaures Alferov, Vice-president of the Russian Academy of Sciences (RAS), Academician of RAS, Nobel laureate, Dirk Bochar, General Secretary of the European Federation of National Engineering Associates (FEANI), Prof. Yuri Gulyaev, Academician of RAS, Member of the Presidium of RAS, President of the International Union of Scientific and Engineering Associations, Director of the Institute of Radio Engineering and Electronics of RAS, as well as rectors of the largest universities in Russia, chief executives of well-known research enterprises and representatives of big businesses. We would like to thank our main sponsors such as JSC &apos;&apos;Reshetnev Information Satellite Systems&apos;&apos;, JSC &apos;&apos;Krasnoyarsk Engineering Plant&apos;&apos;, Central Design Bureau &apos;'Geophysics'&apos;, Krasnoyarsk Region Authorities. These enterprises and companies are leading ones in the aerospace branch. It is a great pleasure to cooperate and train specialists for them. (preface)

  15. Development of an object oriented lattice QCD code &apos;'Bridge++'&apos;

    International Nuclear Information System (INIS)

    Ueda, S; Aoki, S; Aoyama, T; Kanaya, K; Taniguchi, Y; Matsufuru, H; Motoki, S; Namekawa, Y; Nemura, H; Ukita, N

    2014-01-01

    We are developing a new lattice QCD code set &apos;'Bridge++'&apos; aiming at extensible, readable, and portable workbench for QCD simulations, while keeping a high performance at the same time. Bridge++ covers conventional lattice actions and numerical algorithms. The code set is constructed in C++ with an object oriented programming. In this paper we describe fundamental ingredients of the code and the current status of development

  16. The German &apos;'Energiewende'&apos;. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-08-01

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German &apos;'Energiewende'&apos;. The result is clear-cut: The German &apos;'Energiewende'&apos; is inadequate. Due to the cap-and-trade system of the EU the &apos;''Energiewende'&apos;.

  17. Village Power &apos;98

    Energy Technology Data Exchange (ETDEWEB)

    Cardinal, Julie; Flowers, Larry; Siegel, Judy; Taylor, Roger; Weingart, Jerome

    1999-03-24

    This is the fifth Village Power workshop sponsored by NREL. We have held these meetings every year since 1993, to focus, challenge, and provide a forum for interaction among practitioners working in the field of using renewable energy technologies as an economically viable pathway to electrification of rural populations throughout the world. Starting with a small group of 30 colleagues in 1993, this &apos;'workshop'&apos; has doubled in size every year. When the NREL staff was planning for this meeting, they were hoping for something around 400 participants. We are now looking at over 500, and we apologize for the somewhat cramped accommodations. This overwhelming response, however, shows that the use of renewable energy to solve some of the world&apos;s serious problems is coming of age. This meeting, this &apos;'conference'&apos; (it&apos;s clearly no longer a workshop) marks a transition. A transition from the viewpoint that renewables are, and forever will be a technology of the future; to the reality that renewables have come of age. We have technologies available today, at today&apos;s prices, that can make a substantive contribution to the pressing needs of environmentally sustainable development in the world. This is a collection of all the papers presented at the Village Power &apos;98 conference.

  18. Hippocampal &apos;&apos;gliosis only&apos;&apos; on MR imaging represents a distinct entity in epilepsy patients

    Energy Technology Data Exchange (ETDEWEB)

    Hattingen, Elke; Enkirch, Simon Jonas; Jurcoane, Alina; Kruse, Maximilian [University Clinics Bonn, Neuroradiology, Department of Radiology, Bonn (Germany); Delev, Daniel [University Clinics Bonn, Department of Neurosurgery, Bonn (Germany); University Clinics Freiburg, Department of Neurosurgery, Freiburg (Germany); Grote, Alexander [University Clinics Bonn, Department of Neurosurgery, Bonn (Germany); Evangelic Hospital of Bethel, Department of Neurosurgery, Bielefeld (Germany); Becker, Albert [University Clinics Bonn, Institute of Neuropathology, Bonn (Germany)

    2018-02-15

    The purpose of this study is to evaluate whether patients with drug-resistant mesial temporal lobe epilepsy (TLE) due to hippocampal &apos;&apos;gliosis only&apos;&apos; have different MRI features than those with hippocampal sclerosis (HS). Most TLE patients have HS corresponding to severe neuronal loss and gliosis, but a few have &apos;&apos;gliosis only&apos;&apos; without significant reduction of neuronal density. We analyzed the morphology of cerebral 3 T MRIs (T1, T2, and FLAIR) of 103 patients with HS and 20 with &apos;&apos;gliosis only&apos;&apos; concerning hippocampal and amygdala aspect, volumes, and signal intensity (SI) using Fisher&apos;s exact test, Student&apos;s t test, and principal component analysis. Visually, the ipsilateral hippocampus was hyperintense in both groups, but SI was markedly increased in 74% of HS and in 25% of &apos;&apos;gliosis only&apos;&apos; patients; the ipsilateral hippocampus was smaller in 92% of HS and in 50% of &apos;&apos;gliosis only&apos;&apos; patients, and its internal architecture was lost in 57% of HS and 5% of &apos;&apos;gliosis only&apos;&apos; patients; the contralateral hippocampal SI was altered in 25% of HS and in 70% of &apos;&apos;gliosis only&apos;&apos; patients (all p < 0.001). Ipsilateral hippocampus of HS patients had lower volume (mean ± SD 2.86 ± 0.87 ml) compared with that of &apos;&apos;gliosis only&apos;&apos; patients (3.4 ± 1.02 ml) and had higher SI than the contralateral hippocampus of HS patients and then the hippocampus of &apos;&apos;gliosis only&apos;&apos; patients (all p < 0.01). &apos;&apos;Gliosis only&apos;&apos; has different MRI hippocampal characteristics than HS: less volume loss, less increase of the T2-w signal intensity, preservation of internal architecture, and more contralateral affection. (orig.)

  19. Hippocampal &apos;&apos;gliosis only&apos;&apos; on MR imaging represents a distinct entity in epilepsy patients

    International Nuclear Information System (INIS)

    Hattingen, Elke; Enkirch, Simon Jonas; Jurcoane, Alina; Kruse, Maximilian; Delev, Daniel; Grote, Alexander; Becker, Albert

    2018-01-01

    The purpose of this study is to evaluate whether patients with drug-resistant mesial temporal lobe epilepsy (TLE) due to hippocampal &apos;&apos;gliosis only&apos;&apos; have different MRI features than those with hippocampal sclerosis (HS). Most TLE patients have HS corresponding to severe neuronal loss and gliosis, but a few have &apos;&apos;gliosis only&apos;&apos; without significant reduction of neuronal density. We analyzed the morphology of cerebral 3 T MRIs (T1, T2, and FLAIR) of 103 patients with HS and 20 with &apos;&apos;gliosis only&apos;&apos; concerning hippocampal and amygdala aspect, volumes, and signal intensity (SI) using Fisher&apos;s exact test, Student&apos;s t test, and principal component analysis. Visually, the ipsilateral hippocampus was hyperintense in both groups, but SI was markedly increased in 74% of HS and in 25% of &apos;&apos;gliosis only&apos;&apos; patients; the ipsilateral hippocampus was smaller in 92% of HS and in 50% of &apos;&apos;gliosis only&apos;&apos; patients, and its internal architecture was lost in 57% of HS and 5% of &apos;&apos;gliosis only&apos;&apos; patients; the contralateral hippocampal SI was altered in 25% of HS and in 70% of &apos;&apos;gliosis only&apos;&apos; patients (all p < 0.001). Ipsilateral hippocampus of HS patients had lower volume (mean ± SD 2.86 ± 0.87 ml) compared with that of &apos;&apos;gliosis only&apos;&apos; patients (3.4 ± 1.02 ml) and had higher SI than the contralateral hippocampus of HS patients and then the hippocampus of &apos;&apos;gliosis only&apos;&apos; patients (all p < 0.01). &apos;&apos;Gliosis only&apos;&apos; has different MRI hippocampal characteristics than HS: less volume loss, less increase of the T2-w signal intensity, preservation of internal architecture, and more contralateral affection. (orig.)

  20. Overproduction of a kinetic subclass of VLDL-apoB, and direct catabolism of VLDL-apoB in human endogenous hypertriglyceridemia: an analytical model solution of tracer data

    International Nuclear Information System (INIS)

    Eaton, R.P.; Allen, R.C.; Schade, D.S.

    1983-01-01

    To investigate the participation of the major apoprotein involved in triglyceride transport in the pathogenesis of endogenous hypertriglyceridemia, five kinetic studies of apoprotein B were conducted in volunteer normolipidemic subjects and six studies in four patients with endogenous hypertriglyceridemia. The transport of apoprotein B within four kinetic subclasses of very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and low density lipoprotein (LDL) was studied by injection of [ 75 Se]selenomethionine. A 24-fold increase in the entry of newly synthesized apoprotein B at the initial kinetic subclass of the four-compartment VLDL delipidation sequence characterized the hypertriglyceridemic studies relative to normal subjects. Moreover, approximately 75 mg/kg per day of VLDL-B turnover reflected direct catabolism independent of conversion to IDL and/or to LDL, in contrast to the 8 mg/kg per day observed in controls. IDL-B was derived from VLDL-B in both normal and hypertriglyceridemic subjects, and was responsible for greater than 70% of all LDL-B synthesis. LDL-B pool size and turnover were indistinguishable in hypertriglyceridemic subjects from that observed in normal subjects. These studies suggest that two kinetic phenomena may characterize the pathophysiology of endogenous hypertriglyceridemia: a) over-production of apoB within a kinetic subclass of VLDL and b) preferential catabolism of hypertriglyceridemic VLDL without prior conversion to IDL/LDL

  1. Light ions radiobiological effects on human tumoral cells: measurements modelling and application to hadron-therapy; Mesures et modelisation des effets radiobiologiques des ions legers sur des cellules tumorales humaines: application a l&apos;hadrontherapie

    Energy Technology Data Exchange (ETDEWEB)

    Jalade, P

    2005-11-15

    In classical radiotherapy, the characteristics of photons interactions undergo limits for the treatment of radioresistant and not well located tumours. Pioneering treatments of patients at the Lawrence Laboratory at Berkeley has demonstrated two advantages of hadrons beams: the Relative Biologic Effect (the RBE) and the ballistic of the beams. Since 1994, the clinical centre at Chiba, has demonstrated successfully the applicability of the method. A physics group, managed by G. Kraft, at Darmstadt in Germany, has underlined the advantages of carbon beams. An European pool, called ENGIGHT (European Network for LIGHt ion Therapy) has been created in which the French ETOILE project appeared. The purpose of the thesis concerns measurements and models of &apos;in vitro&apos; human cells survival. In the first part, the nowadays situation in particles interactions, tracks and cells structures and radiobiology is presented here. The second is devoted to the models based on the beam tracks and localization of the physical dose. Discussion of sensitivity to various parameters of the model has been realized with the help of numerical simulations. Finally the predictions of the improved model has been compared to experimental irradiations of human cells with argon and carbon beams of the GANIL machine. Conclusion of such study shows the performance and limits of a local model for predicting the radiobiological efficiency of light ions in hadron-therapy. (author)

  2. Promising Role of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Human Immunodeficiency Virus Associated Non-Hodgkin&apos;s Lymphoma

    International Nuclear Information System (INIS)

    Kung, Boom Ting; Mak, W. S.; Lau, S. M. J.; Auyong, T. K.; Tong, C. M.

    2015-01-01

    This case report explores the potential role of FDG PET/CT in HIV -associated systemic non-Hodgkin&apos;s lymphoma (HIV-NHLs). In our locality, there are a cumulative total of 5523 reported HIV infections cases since 1984. We reported a case of HIV-related Burkitt&apos;s lymphoma (BL) and a case of diffuse large B-cell lymphoma (DLBCL) that underwent PET/CT examination in our PET centre. In HIV-NHLs patients, we must be reminded that not all hypermetabolic foci represent lymphomatous lesions. There is a close correlation between the pattern of lymphoid tissue activation in FDG PET/CT and HIV progression in patients without HIV-related malignancy. The unique patterns of lymphoid tissue activation observed in HIV-infected patients have great clinical implications. Secondly, HIV-infected patients are prone to suffer from opportunistic infections due to immunosuppression, particularly in those with high levels of HIV viral loads. FDG PET/CT cannot reliably differentiate metabolic active lymphoma from other benign diseases such as inflammation in the context of low CD4 count and high viral loads. In those cases, benign markedly hypermetabolic foci can be erroneously interpreted as lymphoma, particularly in those normal-sized lymph nodes. Furthermore, FDG PET/CT may be useful for assessing the efficacy of HAART in suppressing HIV replication and detecting its complication such as lipodystrophy. FDG PET/CT may play a potential useful role in staging and management of HIV -associated systemic non-Hodgkin&apos;s lymphoma. Plasma variables such as viral loads and CD4 count must be taken into account during image interpretation. FDG PET/CT as a potential useful tool for diagnosis, treatment response assessment and disease relapse detection in HIV -associated systemic non-Hodgkin&apos;s lymphoma worth to be further explored

  3. Evaluatie van de smogsituatie in de winterperioden &apos;92/&apos;93, &apos;93/&apos;94 en &apos;94/&apos;95

    NARCIS (Netherlands)

    Anker IM van de; LLO

    1996-01-01

    In Nederland bestaat sinds 20 juni 1991 een nieuwe smogregeling, het zogenaamde Modeldraaiboek Smog 1991. In dit modeldraaiboek zijn procedures, maatregelen, handelingen, signaleringsschema&apos;s en aanbevelingen vastgelegd welke betrekking hebben op perioden met verhoogde luchtverontreiniging

  4. Development of emergency response training program based on human factors; Developpement d&apos;un programme de formation pour la reaction aux situations d&apos;urgences base sur les facteurs humains

    Energy Technology Data Exchange (ETDEWEB)

    Nakata, Y. [Osaka Gas Co., Ltd. (Japan)

    2000-07-01

    A training program has been developed at Osaka Gas Co., Ltd. to improve personal response to emergency situations by enabling plant shift chiefs to understand the unique human behavioral patterns that appear during emergencies. The program provides comprehensive and systematic training consisting of lectures and seminars based on a Human Factor Handbook, simulation training, and feedback training. The program can also be applied to all areas of the process industry. (author)

  5. Traveling Chaucer: Comparative Translation and Cosmopolitan Humanism

    Science.gov (United States)

    Barrington, Candace

    2014-01-01

    Through the comparative study of non-Anglophone translations of Geoffrey Chaucer&apos;s "The Canterbury Tales," we can achieve the progressive goals of Emily Apter&apos;s "translational transnationalism" and Edward Said&apos;s "cosmopolitan humanism." Both translation and humanism were intrinsic to Chaucer&apos;s…

  6. The German &apos;'Energiewende'&apos;. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-12-15

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German &apos;'Energiewende'&apos;. The result is clear-cut: The German &apos;'Energiewende'&apos; is inadequate. Due to the cap-and-trade system of the EU the &apos;'Energiewende'&apos; can in no way contribute to climate protection.

  7. Nothing Human

    Science.gov (United States)

    Wharram, C. C.

    2014-01-01

    In this essay C. C. Wharram argues that Terence&apos;s concept of translation as a form of "contamination" anticipates recent developments in philosophy, ecology, and translation studies. Placing these divergent fields of inquiry into dialogue enables us read Terence&apos;s well-known statement "I am a human being--I deem nothing…

  8. European day &apos;&apos;in town, without my car&apos;&apos;; Journee europeen &apos;&apos;en ville, sans ma voiture&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    70 million inhabitants took part in the day &apos;&apos;In town, without my car&apos;&apos; on 22 September of this year. It is a great success for this European first. The objective of Energie-Cites association being to promote sustainable local energy policies, that is to say policies aimed at improving energy efficiency, increasing the use of renewable energy sources and limiting nuisance and pollution linked to energy consumption, the association is pleased that this event helped focus public attention on transport. It is indeed in this sector that uncontrolled upswings in energy consumption and greenhouse gas emissions are the most important. This report presents the evaluation of this European initiative and details the actions in some towns. (A.L.B.)

  9. Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice.

    Science.gov (United States)

    Chan, Elizabeth S; Chen, Christopher; Cole, Gregory M; Wong, Boon-Seng

    2015-09-08

    It is unclear how human apolipoprotein E4 (ApoE4) increases the risk for Alzheimer's disease (AD). Although Aβ levels can lead to insulin signaling impairment, these experiments were done in the absence of human ApoE. To examine ApoE role, we crossed the human ApoE-targeted replacement mice with mutant human amyloid precursor protein (APP) mice. In 26 week old mice with lower Aβ levels, the expression and phosphorylation of insulin signaling proteins remained comparable among APP, ApoE3xAPP and ApoE4xAPP mouse brains. When the mice aged to 78 weeks, these proteins were markedly reduced in APP and ApoE4xAPP mouse brains. While Aβ can bind to insulin receptor, how ApoE isoforms modulate this interaction remains unknown. Here, we showed that ApoE3 had greater association with insulin receptor as compared to ApoE4, regardless of Aβ42 concentration. In contrast, ApoE4 bound more Aβ42 with increasing peptide levels. Using primary hippocampal neurons, we showed that ApoE3 and ApoE4 neurons are equally sensitive to physiological levels of insulin. However, in the presence of Aβ42, insulin failed to elicit a downstream response only in ApoE4 hippocampal neurons. Taken together, our data show that ApoE genotypes can modulate this Aβ-mediated insulin signaling impairment.

  10. Nuclear waste disposal. A wicked and highly conflict bearing societal problem; Nukleare Entsorgung. Ein &apos;'wicked'&apos; und hoechst konfliktbehaftetes Gesellschaftsproblem

    Energy Technology Data Exchange (ETDEWEB)

    Brunnengraeber, Achim; Mez, Lutz [Freie Univ. Berlin (Germany). Forschungszentrum fuer Umweltpolitik; Di Nucci, Maria Rosaria; Schreuers, Miranda [Freie Univ. Berlin (Germany)

    2012-12-15

    The final disposal of nuclear wastes is called &apos;'messy'&apos; or &apos;'wicked'&apos; in the political science literature. The highly complicated problems are characterized by a number of features such as intra- and inter-generational aspects and ethical questions. In the case of stakeholders the differences concern ideologies, interests, merits and preferences that cause conflicts. The search for solutions is complicated due to interacting political, social, ecologic, economic and technical aspects. The concepts &apos;&apos;wicked problems&apos;&apos; and &apos;'multi-level-governance'&apos; are promising approaches to solve the complicated situation.

  11. Jevons&apos; paradox

    Energy Technology Data Exchange (ETDEWEB)

    Alcott, Blake [Gretenweg 4, CH 8038 Zurich (Switzerland)

    2005-07-01

    Technological efficiency; Rebound; Impact; Consumption; Growth; Jevons In The Coal Question William Stanley Jevons [Jevons, W.S., 1865/1965. The Coal Question: an Inquiry Concerning the Progress of the Nation, and the Probable Exhaustion of our Coal-mines. 3rd edition 1905, Ed. A.W. Flux. Augustus M. Kelley, New York.] maintained that technological efficiency gains-specifically the more &apos;economical&apos; use of coal in engines doing mechanical work-actually increased the overall consumption of coal, iron, and other resources, rather than &apos;saving&apos; them, as many claimed. Twentieth-century economic growth theory also sees technological change as the main cause of increased production and consumption. In contrast, some ecologically-oriented economists and practically all governments, green political parties and NGOs believe that efficiency gains lower consumption and negative environmental impact. Others doubt this &apos;efficiency strategy&apos; towards sustainability, holding that efficiency gains &apos;rebound&apos; or even &apos;backfire&apos; in pursuing this goal, causing higher production and consumption. Because many environmental problems demand rapid and clear policy recommendations, this issue deserves high priority in ecological economics. If Jevons is right, efficiency policies are counter-productive, and business-as-usual efficiency gains must be compensated for with physical caps like quotas or rationing.

  12. Investigation of vertebral &apos;&apos;end plate sclerosis&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.W. [Dept. of Rehabilitation Sciences, Hong Kong Polytechnic Univ., Hung Hom (Hong Kong); Mathie, A.G.; Jackson, J.E. [Diagnostic Radiology, Royal Postgraduate Medical School, Hammersmith Hospital, London (United Kingdom); Hughes, S.P.F. [Div. of Surgery, Anaesthetics and Intensive Care, London (United Kingdom)

    2001-08-01

    To evaluate the association between vertebral &apos;&apos;end plate sclerosis&apos;&apos; and neck pain. A retrospective study was carried out of lateral cervical spine radiographs with a Picture Archive and Communication System (PACS). Two hundred patients&apos; files were randomly assessed, comprising four equal groups, A to D. The mean ages of the patients were 62{+-}7.4 years, 61{+-}7.5 years, 40{+-}5.6 years and 23{+-}5.6 years respectively. In group A, all patients had symptoms of neck pain and a radiographic diagnosis of &apos;&apos;end plate sclerosis&apos;&apos; of the cervical spine. In groups B to D, asymptomatic patients were recruited and their age groups were 50-69, 30-49 and 10-29 years respectively. Using the PACS, the radiographic density and the sagittal diameter, thickness and area of the end plates at the C5 level were measured. Results and conclusions: No significant differences were found in the radiographic density of the end plates either between the symptomatic and asymptomatic groups (groups A and B), or between different age groups (groups B, C and D). A significant increase in end plate area and thickness was found, however, in both group B (P<0.005) and group C (P<0.01) in comparison with group D. This indicates that the extent of end plate sclerosis increases with age. Our results suggest that the radiographic density of cervical vertebral end plates correlates neither with neck pain nor with increasing age. The radiological sign of &apos;&apos;end plate sclerosis&apos;&apos; may be over-reported, further limiting its value in the assessment of patients with cervical spondylosis. (orig.)

  13. Backbone and sidechain 1H, 13C and 15N resonance assignments of the human brain-type fatty acid binding protein (FABP7) in its apo form and the holo forms binding to DHA, oleic acid, linoleic acid and elaidic acid

    DEFF Research Database (Denmark)

    Oeemig, Jesper S; Jørgensen, Mathilde L; Hansen, Mikka S

    2009-01-01

    In this manuscript, we present the backbone and side chain assignments of human brain-type fatty acid binding protein, also known as FABP7, in its apo form and in four different holo forms, bound to DHA, oleic acid, linoleic acid and elaidic acid.......In this manuscript, we present the backbone and side chain assignments of human brain-type fatty acid binding protein, also known as FABP7, in its apo form and in four different holo forms, bound to DHA, oleic acid, linoleic acid and elaidic acid....

  14. Emotions, visions and communications. &apos;&apos;Heartbeats inclusive&apos;&apos;; Emotionen, Visionen und Kommunikationen. &apos;&apos;Herzklopfen inklusive&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rinderknecht, F.M. [Rinspeed AG, Zumikom (Germany)

    2006-07-01

    Emotional aspects become more and more relevant and important in today&apos;s consumer world. It is not only the technical features or the price which influence decisions for buying or not, but non-tangible elements as brand name, image, imaginary value, personal positioning and other emotions. Products become more and more equal as well as their performance sets no differentiation. Therefore marketing and sales strategies call for emotional differentiations. One very successful example on today&apos;s market is the I-Pod - nothing simpler than a MP3-player which fetches three times the monetary revenue and has some times even a waiting list. Why? Because it is &apos;'cool'&apos; and a status symbol to own one. The same thinking needs to be applied in the marketing and sales activities of natural gas as a mobile fuel as well. Having many important functional disadvantages over gasoline such as a small number of filling stations, limited range of models offered and sometimes limited range and national offer, not only the financial aspects of saving fuel costs, but the emotional positioning of the buyer is very important: To be environment conscious, to be the first, to be different, to be responsible, to be looked at as a trend-setter, and to possibly have power equal to the equivalent in gasoline engines. (orig.)

  15. Some problems of human ecology

    International Nuclear Information System (INIS)

    Davitashvili, M.

    2009-01-01

    The problems of the ecology of human are considered. The notion of &apos;&apos;the ecology of human'&apos; is discussed from the viewpoint of human rights and responsibilities in reference to the environment. The ecological factors affecting the men and the ecosystems as a whole are considered. It is emphasized that the ecological problems should be solved not only globally, but also for concrete ecosystems with consideration for their specific features. (author)

  16. Students&apos;, Guardians&apos;, and Teachers&apos; Perceptions of Student-Led Conferences

    Science.gov (United States)

    Orso, Charlotte Lindsey

    2013-01-01

    The purpose of the study was to examine the ELL and non-ELL students&apos;, guardians&apos;, and the English as a second language (ESL) teachers&apos; perceptions of student-led conferences. Specifically, the study examined if ELL students&apos; and guardians&apos; preferences were similar to non-ELL students&apos; and guardians&apos; preferences…

  17. Metabolic activation of volatile organic compounds and polycyclic aromatic hydrocarbons coated onto airborne PM{sub 2.5} in isolated human alveolar macrophages; Etude de l&apos;activation metabolique des composes organiques volatils et des hydrocarbures aromatiques polycycliques d&apos;un aerosol anthropogenique par des macrophages alveolaires humains en culture primaire

    Energy Technology Data Exchange (ETDEWEB)

    Saint-Georges, F.; Mulliez, P. [Hopital Saint Philibert - GHICL-FLM, Service de Pneumologie, 59 - Lomme (France); Saint-Georges, F.; Abbas, I.; Garcon, G.; Billet, S.; Verdin, A.; Shirali, P. [LCE-EA2598, Lab. de Recherche en toxicologie Industrielle et Environnementale - ULCO-MREI, 59 - Dunkerque (France); Gosset, P. [Hopital Saint Vincent, Laboratoire d' Anatomie et de Cytologie Pathologiques - GHICL-FLM, 59 - Lille (France); Courcot, D. [LCE-EA2598, Lab. de Catalyse et Environnement - ULCO-MREI, 59 - Dunkerque (France)

    2009-01-15

    To contribute to improve the knowledge of the underlying mechanisms of action involved in air pollution Particulate Matter (PM)-induced cytotoxicity, we were interested in the metabolic activation of Volatile Organic Compounds (VOC) and/or Polycyclic Aromatic Hydrocarbons (PAH)-coated onto Dunkerque City&apos;s PM{sub 2.5} in human Alveolar Macrophages (AM) isolated from Bronchoalveolar Lavage Fluid (BALF). This in vitro cell lung model is very close to the normal in vivo situation, notably in the characteristics that AM display in terms of gene expression of phase I and phase II-metabolizing enzymes. The bronchoscopic examinations and BAL procedures were carried out without any complications. The exposure of AM, during 24, 48 or 72 h, to increasing concentrations of the collected aerosol induced significant variations of the activities of the extracellular lactate dehydrogenase and the mitochondrial dehydrogenase. The lethal concentrations at 10% and 50% were 14.93 and 74.63 {mu}g/mL for AM, respectively, and indicated the relatively higher sensibility of such target lung cells. VOC and/or PAH-coated at low levels onto the surface of the particulate fraction significantly induced gene expression of cytochrome P450 (GYP) 1A1, CYP2E1, NADPH Quinone oxido-reductase (NQO)-1) and Glutathione S-Transferase (GST)P1 and M3, versus controls, suggesting thereby the formation of biologically reactive metabolites. Moreover, these results suggested the role of physical vector of carbonaceous core of PM, which can, therefore, increase both the penetration and the retention of attached-VOC into the cells, thereby enabling them to exert a more durable induction. Hence, we concluded that the metabolic activation of the very low doses of VOC and/or PAH-coated onto Dunkerque City&apos;s PM{sub 2.5} is one of the underlying mechanisms of action closely involved in its cytotoxicity in isolated human AM in culture. (author)

  18. Coral bleaching and ocean &apos;&apos;hot spots&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Goreau, T.J. (Global Coral Reef Alliance, Chappaqua, NY (United States)); Hayes, R.L. (Howard Univ., Washington, DC (United States). College of Medicine)

    1994-05-01

    Global sea-surface temperature maps show that mass coral-reef bleaching episodes between 1983 and 1991 followed positive anomalies more than 1 deg C above long-term monthly averages (&apos;&apos;hot spots&apos;&apos;) during the preceding warm season. Irregular formation, movement, and disappearance of hot spots make their detailed long-term prediction impossible, but they can be tracked in real time from satellite data. Monitoring of ocean hot spots and of coral bleaching is needed if the Framework Convention of Climate Change is to meet its goal of protecting the most temperature sensitive ecosystems. 47 refs, 3 figs

  19. Criteria of transformation of object &apos;'Ukryttya'&apos; in environmentally safe system

    International Nuclear Information System (INIS)

    Batyij, V.G.; Jegorov, V.V.; Rud'ko, V.M.; Shcherbyin, V.M.

    2015-01-01

    The analysis of criteria of division of radioactive wastes (RAW) of object &apos;'Ukryttya'&apos; is executed on short-lived and long-lived, and their activity. It is shown that to short-lived RAW underactive belong and insignificant part of me-dium-activity waste. Hundreds of thousands of m3 of RAW on overhead marks belong to long-lived medium-activity wastes. Organization of burial place of such wastes in stable geological structures is an unrealistic task. It is suggested to create the special depository for such RAW, and buried in stable geological structures high-activity wastes only

  20. Chamber transport of &apos;'foot'&apos; pulses for heavy-ion fusion

    Energy Technology Data Exchange (ETDEWEB)

    Sharp, W.M.; Callahan-Miller, D.A.; Tabak, M.; Yu, S.S.; Peterson, P.F.

    2002-02-20

    Indirect-drive targets for heavy-ion fusion must initially be heated by &apos;'foot'&apos; pulses that precede the main heating pulses by tens of nanoseconds. These pulses typically have a lower energy and perveance than the main pulses, and the fusion-chamber environment is different from that seen by later pulses. The preliminary particle-in-cell simulations of foot pulses here examine the sensitivity of the beam focusing to ion-beam perveance, background-gas density, and pre-neutralization by a plasma near the chamber entry port.

  1. The role of &apos;&apos;momentum removal&apos;&apos; in divertor detachment

    Energy Technology Data Exchange (ETDEWEB)

    Kukushkin, A.S. [Kurchatov Institute, Moscow (Russian Federation); NRNU MEPhI, Moscow (Russian Federation); Pacher, H.D. [INRS-EMT, Varennes, Quebec (Canada)

    2016-08-15

    The role of &apos;&apos;momentum removal&apos;&apos; (the drag force on the plasma ion flow) in divertor detachment is considered and analysed in detail. This analysis of the 2D modelling results shows that the drag force cannot reduce the power and particle flux to the target directly. However, it is essential for creating the conditions for efficient radiation and volumetric plasma recombination, which in turn do the job. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  2. &apos;&apos;After the Genome 5 Conference&apos;&apos; to be held October 6-10, 1999 in Jackson Hole, Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    Roger Brent

    1999-10-06

    OAK B139 The postgenomic era is arriving faster than anyone had imagined--sometime during 2000 we&apos;ll have a large fraction of the human genome sequence. Heretofore, our understanding of function has come from non-industrial experiments whose conclusions were largely framed in human language. The advent of large amounts of sequence data, and of &apos;&apos;functional genomic&apos;&apos; data types such as mRNA expression data, have changed this picture. These data share the feature that individual observations and measurements are typically relatively low value adding. Such data is now being generated so rapidly that the amount of information contained in it will surpass the amount of biological information collected by traditional means. It is tantalizing to envision using genomic information to create a quantitative biology with a very strong data component. Unfortunately, we are very early in our understanding of how to &apos;&apos;compute on&apos;&apos; genomic information so as to extract biological knowledge from i t. In fact, some current efforts to come to grips with genomic information often resemble a computer savvy library science, where the most important issues concern categories, classification schemes, and information retrieval. When exploring new libraries, a measure of cataloging and inventory is surely inevitable. However, at some point we will need to move from library science to scholarship.We would like to achieve a quantitative and predictive understanding of biological function. We realize that making the bridge from knowledge of systems to the sets of abstractions that constitute computable entities is not easy. The After the Genome meetings were started in 1995 to help the biological community think about and prepare for the changes in biological research in the face of the oncoming flow of genomic information. The term &apos;&apos;After the Genome&apos;&apos; refers to a future in which complete inventories of the gene products of

  3. Water source heat pumps at the &apos;'Oceanopolis'&apos; park of Brest; Des PAC sur boucle d&apos;eau au parc &apos;'Oceanopolis'&apos; de Brest

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2000-01-01

    The creation of the new &apos;polar&apos; and &apos;tropical&apos; lodges of the &apos;Oceanopolis&apos; park (aquarium and greenhouses) of Brest (Brittany, France) has led to chose the solution of water source heat pumps for the energy production. More than 30 thermodynamic machineries are used to supply both heat and coldness to the installations. This paper describes the technical characteristics of the heating/refrigerating installations, their energy performances and the estimated cost-benefit aspects. (J.S.)

  4. Do we need a &apos;&apos;green medicine&apos;&apos;?; Brauchen wir &apos;&apos;Gruene Medizin?&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, M.; Daschner, F.; Scherrer, M. [Universitaetsklinikum Freiburg (Germany)

    2006-07-01

    Spontaneously, we do associate &apos;&apos;green medicine&apos;&apos; with terms like naturopathy, natural healing substances, herbal active agents, homeopathy, healthy food, preventive medicine and similar things, and finally we think of ecology. This is the focus of the following article. First of all, the following question arises: Are there any environment-friendly and cost-saving alternatives to the present medicine? There is an increasing number of environment-caused diseases. Therefore, a medicine not coping with the environment is not credible. In today&apos;s medicine, for example, there are too many persistent detergents, water-polluting disinfectants, and many disposable materials. Too much water ist consumed, whereas the use of renewable energies is only limited. And too little natural healing methods are applied in diagnostics and therapy. Presently, in Germany, 16,7 million in-patients are treated in Germany, 1,16 million out-patients have surgeries in 2166 hospitals by ca. 1,1 million medical staff. All this work needs energy and materials which bring various risks to environment and the patients. During the last two decades, however, many efforts were made in the field of environment protection in medicine. There is hardly a hospital left which has not taken measures of protecting the environment. In the branch-specific quality management system KTQ (=cooperation for transparency and quality in the health system). environment protection measures are interrogated and systematically assessed.

  5. Agreement &apos;&apos;power networks and environment&apos;&apos; 2001-2003; Accord &apos;&apos;reseaux electriques et environnement&apos;&apos; 2001-2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-01-01

    This agreement, discussed between the French government and Electricite de France (EdF) group, proposes some engagements for the 2001-2003 era for a better environmental integration of power transmission and distribution networks. The agreement is made of two parts: 1 - public distribution networks: realization of new workmanship (medium and low voltage power lines, new lines in dense urban areas), actions on existing workmanship (consequences of December 1999 storms, aesthetical aspects, burial of the main overhead lines in wooded areas, reinforcement of EdF&apos;s environmental commitment, remedial actions for environmental &apos;black points&apos;), general measures of implementation (increasing network safety, protection of birds fauna, coordination of works); 2 - public transportation network (RTE): development and safety improvement of the public transportation network (reinforced arrangement for the establishment of regional development schemes, development of international interconnections, safety improvement of the public transportation network, RTE&apos;s environmental plan); line projects (arrangements during projects elaboration, accompanying program); long lived RTE&apos;s commitment (environmental management and ISO-14001 certification, vigilance with respect to electromagnetic fields, R and D). (J.S.)

  6. &apos;&apos;Measuring the Costs of Climate Change Policies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P.M.

    2003-05-09

    Studies of the costs of climate change policies have utilized a variety of measures or metrics for summarizing costs. The leading economic models have utilized GNP, GDP, the &apos;&apos;area under a marginal cost curve,&apos;&apos; the discounted present value of consumption, and a welfare measure taken directly from the utility function of the model&apos;s representative agent (the &apos;&apos;Equivalent Variation&apos;&apos;). Even when calculated using a single model, these metrics do not necessarily give similar magnitudes of costs or even rank policies consistently. This paper discusses in non-technical terms the economic concepts lying behind each concept, the theoretical basis for expecting each measure to provide a consistent ranking of policies, and the reasons why different measures provide different rankings. It identifies a method of calculating the &apos;&apos;Equivalent Variation&apos;&apos; as theoretically superior to the other cost metrics in ranking policies. When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank

  7. Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia

    NARCIS (Netherlands)

    Schaap, Frank G.; Nierman, Melchior C.; Berbée, Jimmy F. P.; Hattori, Hiroaki; Talmud, Philippa J.; Vaessen, Stefan F. C.; Rensen, Patrick C. N.; Chamuleau, Robert A. F. M.; Kuivenhoven, Jan Albert; Groen, Albert K.

    2006-01-01

    The relevance of apolipoprotein A-V (apoA-V) for human lipid homeostasis is underscored by genetic association studies and the identification of truncation-causing mutations in the APOA5 gene as a cause of type V hyperlipidemia, compatible with an LPL-activating role of apoA-V. An inverse

  8. From the &apos;PCR&apos; function to the &apos;PCR&apos; profession; de la fonction &apos;PCR&apos; au metier &apos;PCR&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Perrin, L. [CERAP, 91 - Gif sur Yvette (France)

    2008-07-01

    After having recalled the legal context concerning the appointment and training of a radiation protection expert (PCR for &apos;personne competente en radioprotection&apos;), the author outlines that the PCR&apos;s role has notably evolved: his function is now of primary importance in the company and his activity does not correspond to the legal framework any longer. Moreover, with the application of a European directive, some small establishments possessing ionizing radiation sources are disadvantaged, and the PCR is now facing an increasing number of missions and tasks. The author gives a list of them and assesses a needed time of 146 days per year: this means PCRs cannot have an other activity within their company

  9. Spherically symmetric conformal gravity and &apos;&apos;gravitational bubbles&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Berezin, V.A.; Dokuchaev, V.I.; Eroshenko, Yu.N., E-mail: berezin@inr.ac.ru, E-mail: dokuchaev@inr.ac.ru, E-mail: eroshenko@inr.ac.ru [Institute for Nuclear Research, Russian Academy of Sciences, 60th October Anniversary Prospect 7a, Moscow, 117312 (Russian Federation)

    2016-01-01

    The general structure of the spherically symmetric solutions in the Weyl conformal gravity is described. The corresponding Bach equations are derived for the special type of metrics, which can be considered as the representative of the general class. The complete set of the pure vacuum solutions is found. It consists of two classes. The first one contains the solutions with constant two-dimensional curvature scalar of our specific metrics, and the representatives are the famous Robertson-Walker metrics. One of them we called the &apos;&apos;gravitational bubbles&apos;&apos;, which is compact and with zero Weyl tensor. Thus, we obtained the pure vacuum curved space-times (without any material sources, including the cosmological constant) what is absolutely impossible in General Relativity. Such a phenomenon makes it easier to create the universe from &apos;'nothing'&apos;. The second class consists of the solutions with varying curvature scalar. We found its representative as the one-parameter family. It appears that it can be conformally covered by the thee-parameter Mannheim-Kazanas solution. We also investigated the general structure of the energy-momentum tensor in the spherical conformal gravity and constructed the vectorial equation that reveals clearly some features of non-vacuum solutions. Two of them are explicitly written, namely, the metrics à la Vaidya, and the electrovacuum space-time metrics.

  10. 66. The safety engineering at reprocessing of raw material from &apos;zero&apos; mark and &apos;slaked lime&apos;

    International Nuclear Information System (INIS)

    Ivanov, A.V.

    1993-01-01

    The safety engineering at reprocessing of raw material from &apos;zero&apos; mark and &apos;slaked lime&apos; was studied. All operational conditions at reprocessing of raw material from &apos;zero&apos; mark and &apos;slaked lime&apos; were discussed.

  11. Preparation of data relevant to &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and Equivalent Initial Enrichment&apos;&apos; for burnup credit evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Nomura, Yasushi; Okuno, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Murazaki, Minoru [Tokyo Nuclear Service Inc., Tokyo (Japan)

    2001-11-01

    Based on the PWR spent fuel composition data measured at JAERI, two kinds of simplified methods such as &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and &apos;&apos;Equivalent Initial Enrichment&apos;&apos; have been introduced. And relevant evaluation curves have been prepared for criticality safety evaluation of spent fuel storage pool and transport casks, taking burnup of spent fuel into consideration. These simplified methods can be used to obtain an effective neutron multiplication factor for a spent fuel storage/transportation system by using the ORIGEN2.1 burnup code and the KENO-Va criticality code without considering axial burnup profile in spent fuel and other various factors introducing calculated errors. &apos;&apos;Equivalent Uniform Burnup&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis, in which the experimentally obtained isotopic composition together with a typical axial burnup profile and various factors such as irradiation history are considered on the conservative side. On the other hand, Equivalent Initial Enrichment&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis such as above when it is used in the so called fresh fuel assumption. (author)

  12. In vitro cytotoxic effects of PM{sub 2.5} from the city of Abidjan (Ivory Coast) on human A549 lung cells; Effets cytotoxiques in vitro des PM{sub 2,} {sub 5} de la ville d&apos;Abidjan (Cote-d&apos;Ivoire) sur des cellules pulmonaires humaines

    Energy Technology Data Exchange (ETDEWEB)

    Kouassi, Kouakou-Serge [Universite Lille Nord de France, Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, EA 4492 MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Universite Cocody-Abidjan et Institut Pasteur, Abidjan (Cote d' Ivoire); Billet, Sylvain; Garcon, Guillaume; Verdin, Anthony; Courcot, Dominique; Shirali, Pirouz [Universite Lille Nord de France, Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, EA 4492 MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Diouf, Amadou [Laboratoire de Toxicologie, Faculte de Medecine Pharmacologie Odontologie, Universite Cheikh Anta Diop, Dakar (Senegal); Cazier, Fabrice [Universite Lille Nord de France, Lille (France); Centre Commun de Mesures, MREI 1, Universite du Littoral Cote d' Opale, Dunkerque (France); Djaman, Joseph [Universite Cocody-Abidjan et Institut Pasteur, Abidjan (Cote d' Ivoire)

    2012-01-15

    Epidemiological studies associate air pollution, especially particulate, increased morbidity and mortality from respiratory and cardiovascular origin . Africa, which has an urbanization rate among the highest in the world, is particularly exposed. The &apos;Initiative on the air quality in Sub-Saharan Africa&apos; showed the importance of atmospheric concentrations of certain pollutants such as nitrogen oxides, sulfur dioxide and particulate matter (PM{sub 10}). Like the great capitals of Africa, Abidjan, economic capital and most industrialized city of Ivory Coast is facing an air pollution from industrial-urban and health consequences for its population of nearly 6 million inhabitants. To better understand the mechanisms of action resulting from pulmonary exposure to particulate atmospheric aerosols, we proposed: (i) to collect atmospheric particles (PM{sub 2.5}) using high volume cascade impaction in the District of Abidjan in three influences (rural, urban or industrial), (ii) to determine their main physicochemical, (iii) assess their cytotoxicity and their role in the induction of oxidative damage in a model of human lung cells (A549) in culture. The chemical composition of the atmospheric particles revealed their heterogeneity, and many inorganic (e.g. Al, Ca, Fe, Mn, Zn, Ni, Cr, Cu, Pb, Mg) and organic compounds (e.g. paraffins) were quantified at the three sites. Their effect concentrations (EC) to 10 and 50% on the A549 were as follows: influence rural: EC{sub 10} = 5.91 {mu}g/cm{sup 2} and EC{sub 50} 29.55 {mu}g/cm{sup 2}, urban influence: EC{sub 10} = 5 .45 {mu}g/cm{sup 2} and EC{sub 50} = 27.23 {mu}g/cm{sup 2}, and industrial influence: EC{sub 10} = 6.86 {mu}g/cm{sup 2} and EC{sub 50} = 34.29 {mu}g/cm{sup 2}. Exposure of A549 cells to Abidjan city&apos;s PM samples for 24, 48 or 72 hours to their EC{sub 10} or EC{sub 50} induced oxidative damage, as demonstrated by the formation of malon-dialdehyde, changes in enzyme activity of superoxide dismutase

  13. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice

    NARCIS (Netherlands)

    Winther, M.P.J. de; Gijbels, M.J.J.; Dijk, K.W. van; Gorp, P.J.J. van; Suzuki, H.; Kodama, T.; Frants, R.R.; Havekes, L.M.; Hofker, M.H.

    1999-01-01

    Apolipoprotein (apo) E3Leiden is a dysfunctional apo E variant associated with familial dysbetalipoproteinemia in humans. Transgenic mice carrying the APOE3Leiden gene develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. An early step in atherosclerosis is foam cell

  14. Fiscal 1999 research report on long-term energy technology strategy. Basic research on industrial technology strategy (Individual technology strategy). Electronic information technology field (Human process ware field for computers); 1999 nendo choki energy gijutsu senryaku nado ni kansuru chsao hokokusho. Sangyo gijutsu senryaku sakutei kiban chosa (bun&apos;yabetsu gijutsu senryaku) denshi joho gijutsu bun&apos;ya (computer kanren bun&apos;ya no uchi, human process wear bun&apos;ya)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This report summarizes the fiscal 1999 basic research result on industrial technology strategy of a human process ware (HPW) field on electronic information. Although the current HPW industry is not yet complete, various technologies concerned are being stored, and the HPW industry is expected as new major industry for home and personal information equipment. As factors hindering technological innovation in Japan, the incomplete market, poor cooperation between industry and government, ambiguous role of university, and poor standardization were pointed out. Technology trends were analyzed to extract seed technology fields from 3 viewpoints of mobile HPW available at any time, at any place and to anybody, HPW system capable of customizing every personal use, and HPW supporting development of a creativity. As general strategy, the technology seed chart and map of technical development targets for every HPW were prepared to conceive a route to practical use, and develop element technologies required for practical use, based on the future trend of the market. (NEDO)

  15. Association of Papillary Thyroid Carcinoma and Graves&apos; Disease. Unexpected Development and Efficiency of Ablative Dose with Recombinant Human Thyrotropin (rhTSH)

    International Nuclear Information System (INIS)

    Pacenza, N.A.; Groppo, N.; Guibourg, H.C.

    2013-01-01

    Differentiated thyroid cancer (DTC) associated with Graves&apos; disease (GD) is a relatively rare disease, occurring in 0.3 % to 9.8 % of GD patients. Some studies suggest an increased aggressiveness of DTC in GD patients, apparently related to thyroid stimulating antibodies. We report the case of a patient with DTC and GD, describing his peculiar evolution. Case report: 22-year-old male who presented with obesity. History of a cousin with DTC and grandmother and mother with goiter. Physical examination: Weight: 116.4 kg, height: 1.73 m, BMI: 38.9. Clinically euthyroid. Thyroid palpation was difficult due to his thick neck. Initial analysis: T3, T4 and TSH within normal range. Thyroid ultrasound (US) showing 11 x 10 mm hypoechoic nodule in right lobe (RL). US-guided fine-needle aspiration (FNA) was requested. Four months later, the patient returned with clinical symptoms of hyperthyroidism (diarrhea, palpitations, insomnia, tremors, cramps and difficulty walking). Laboratory: T3: 557 ng/dl, T4: 18.8 mcg/dl, FT4: 3.73 ng/dl, TSH <0.01 μIU/mL, TPOA: 186 IU/mL, TGA: 965 IU/mL. US-guided FNA: &apos;Cytological findings are related to papillary thyroid cancer . Thyroid Scan: D iffuse enlargement of the gland, &apos;warm&apos; nodule in RL . I 131 uptake was: 1st hour: 12 %, 24 hours: 58 %. He received methimazole 20 mg daily. He was operated on 2 months later ( t otal thyroidectomy ) . Pathology: F ollicular variant of papillary thyroid carcinoma in right lobe and classical variant of papillary carcinoma in area of the left lobe . Thirty-five days after surgery (S) (without levothyroxine): TSH <0.01 μIU/mL, Thyroglobulin (Tg) 32.1 ng/mL. Sixty days after S: TSH <0.1 μIU/mL, FT4 1.2 ng/dL, T3 1.3 ng/dL. Clinically euthyroid with normal neck palpation. Chest Computed axial tomography (CT): N ormal . US of the neck: B ilateral thyroid lodge is free . Ninety days later: TSH 0.32 μIU/mL, TRAb 29 % (normal: until 15 %). Thyroid Scan with 99m Tc pertechnetate: P

  16. &apos;'VaneCAM'&apos; - the third generation of camshaft adjustment systems; &apos;'VaneCAM'&apos; - Nockenwellenversteller der dritten Generation

    Energy Technology Data Exchange (ETDEWEB)

    Knecht, A. [Hydraulik-Ring GmbH, Nuertingen (Germany). Entwicklung Motorentechnik; Stephan, W. [Hydraulik-Ring GmbH, Nuertingen (Germany); Hannibal, W. [Fachhochschule Suedwestfalen, Iserlohn (Germany). Labor fuer Konstruktion und CAE-Anwendungen

    2002-04-01

    Continuously variable camphasers are now well established for modern spark-ignition engines in high-volume production. With the latest generation of camshaft adjustment systems using the vane-type actuator principle, it is possible to move rapidly and reliably through a large adjustment angle. The layout of these adjusting systems is very simple. The production costs are low in comparison to the first generation of camphasers using spur/helical gears to vary the valve timing. The new-generation systems are mechatronic, with the function depending on the coordination and tuning of hydraulic actuation and engine electronics. The term &apos;VaneCAM&apos; is used for the continuously variable systems of this new generation supplied by Hydraulik-Ring in Nuertingen, Germany. (orig.) [German] Stufenlos wirkende Nockenwellenversteller haben sich an modernen Ottomotoren in den letzten Jahren in der Grossserie etabliert. Mit der neuesten Generation von Nockenwellenverstellern, die nach dem Schwenkmotor-Prinzip aufgebaut sind, lassen sich grosse Verdrehwinkel sehr schnell und betriebssicher verstellen. Der Aufbau dieser Versteller ist einfach, und die Herstellkosten sind gering im Vergleich zur ersten Generation von Verstellern. Bei den Systemen der neuen Generation handelt es sich um mechatronische Systeme, deren Funktion von dem Zusammenspiel und der Abstimmung von hydraulischer Ansteuerung und Motorelektronik abhaengt. Mit dem Begriff &apos;VaneCAM&apos; werden die stufenlos wirkenden Systeme dieser neuen Generation von Hydraulik-Ring aus Nuertingen bezeichnet. (orig.)

  17. Recognizing IT risks - acting with foresight or: &apos;&apos;practical reasons for comprehensive IT security&apos;&apos;; IT-Risiken erkennen, vorausschauend handeln oder: &apos;&apos;Praktische Gruende fuer umfassende IT-Security&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schaeffer, P.A.R. [TUeV Rheinland Secure iT GmbH, Koeln (Germany)

    2006-07-01

    Comprehensive IT security expects all threats and every possible consequence to be identified in order to deduce and develop appropriate counter measures. This article describes two exemplary threats to an IT infrastructure: &apos;Hacking Internal Networks&apos; and &apos;A High Promising Target: Web Applications&apos;. (orig.)

  18. Sustainable Agriculture: enhancing the &apos;neem cake&apos;

    International Nuclear Information System (INIS)

    Mariani, Susanna

    2015-01-01

    The &apos;neem cake&apos; is the scrap processing of the industrial chain producing neem oil and azadirachtin. The ENEA Technical Unit Environment and Sustainable Development Innovation the Agro-Industrial System, developed a promising experiment to promote the use of &apos;neem cake&apos; as an insecticide, and fertilizer of low cost in sustainable agriculture. [it

  19. Parents&apos; Views of Schools&apos; Involvement Efforts

    Science.gov (United States)

    Rodriguez, Raymond J.; Blatz, Erin T.; Elbaum, Batya

    2014-01-01

    Individual and focus group interviews were conducted with 96 parents of students with disabilities in 18 schools to explore parents&apos; views of schools&apos; efforts to engage them in their child&apos;s education. A mixed-methods approach was used to identify and evaluate the relative importance of eight themes related to schools&apos; efforts…

  20. Development and Validation of an Instrument to Assess Social Work Students&apos; Perceptions, Knowledge, and Attitudes about Human Trafficking Questionnaire (PKA-HTQ): An Exploratory Study

    Science.gov (United States)

    Nsonwu, Maura Busch; Welch-Brewer, Chiquitia; Heffron, Laurie Cook; Lemke, Melinda A.; Busch-Armendariz, Noel; Sulley, Caitlin; Cook, Sharon Warren; Lewis, Mary; Watson, Elizabeth; Moore, Wayne; Li, Jilan

    2017-01-01

    Objective: This study sought to develop and evaluate the psychometric properties of a tool designed to assess social work students' knowledge of and perceptions and attitudes toward human trafficking. To achieve this aim, the Perceptions, Knowledge, and Attitudes toward Human Trafficking Questionnaire (PKA-HTQ) was developed and its psychometric…

  1. The Impact of a Novel Curriculum on Secondary Biology Teachers&apos; Dispositions toward Using Authentic Data and Media in Their Human Impact and Ecology Lessons

    Science.gov (United States)

    Wyner, Yael

    2013-01-01

    This study examines how the implementation of a novel curriculum, that emphasizes the use of published scientific data and media to learn about human impact and ecological function, influenced ninth-grade biology teacher (N - 36) dispositions toward using data and media in their ecology and human impact lesson plans. It explores how integration of…

  2. What do we mean by the word &apos;'Shock'&apos;?

    International Nuclear Information System (INIS)

    Runnels, Scott Robert

    2015-01-01

    From one vantage point, a shock is a continuous but drastic change in state variables that occurs over very small time and length scales. These scales and associated changes in state variables can be measured experimentally. From another vantage point, a shock is a mathematical singularity consisting of instantaneous changes in state variables. This more mathematical view gives rise to analytical solutions to idealized problems. And from a third vantage point, a shock is a structure in a hydrocode prediction. Its width depends on the simulation&apos;s grid resolution and artificial viscosity. These three vantage points can be in conflict when ideas from the associated fields are combined, and yet combining them is an important goal of an integrated modeling program. This presentation explores an example of how models for real materials in the presence of real shocks react to a hydrocode&apos;s numerical shocks of finite width. The presentation will include an introduction to plasticity for the novice, an historical view of plasticity algorithms, a demonstration of how pursuing the meaning of &apos;'shock'&apos; has resulted in hydrocode improvements, and will conclude by answering some of the questions that arise from that pursuit. After the technical part of the presentation, a few slides advertising LANL&apos;s Computational Physics Student Summer Workshop will be shown.

  3. &apos;&apos;Camouflage line&apos;&apos; for 380 kV; Erfahrungen mit einer 380-kV-&apos;'Tarnleitung'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Egger, H. [FAS Berndorf GmbH and Co. KG, Berndorf (Austria); Lugschitz, H. [Verbund-Austrian Power Grid GmbH, Wien (Austria)

    2000-10-16

    Overhead transmission lines are under increased public discussion. One method to minimize their influence on the environment and therefore to increase their acceptance is to camouflage lines by coating their components. Towers, conductors and fittings of a line which was erected recently in the Austrian Alps are coated in dark green colour to make the structure less visible against the background. For further reduction of visibility the line is constructed as compact line. The smaller tower size was achieved by use of short insulator strings and by oversized conductors with special advantageous mechanical properties. This paper explains the consideration which led to the configuration as compact line and for the decision to coate the complete line. It also presents long term experience with in-factory-coating of towers. Factory-coated supports were introduced 1982 in the company&apos;s network, first with the main goal to ease maintenance and second to reduce impacts on the environment. The first complete &apos;camouflage line&apos; (coloured supports and coloured conductors) in the Austrian grid was set into operation end of the year 1995. (orig.) [German] Freileitungen stehen unter zunehmender oeffentlicher Diskussion. Eine der Methoden, ihren Einfluss auf die Umwelt zu reduzieren und damit ihre Akzeptanz zu erhoehen, ist, die Tarnung von Leitungen durch Faerbung ihrer Komponenten. Maste, Leiter, Erdseile und Armaturen einer in den Oesterreichischen Alpen errichtenden Leitungen wurden in dunkelgruener Farbe beschichtet, um die Anlage gegenueber dem Hintergrund geringer sichtbar zu machen. Zur weiteren Reduktion der Sichtbarkeit ist die Leitung als &apos;Kompaktleitung&apos; ausgefuehrt. Die geringeren Mastabmessungen wurden durch die Verwendung von kuerzeren Isolatorenketten und Leiterseilen mit besonders vorteilhaften mechanischen Eigenschaften erreicht. Die Verfasser erklaeren die Ueberlegungen, die zu der Ausfuehrung als Kompaktleitung und zur Beschichtung der

  4. The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.

    Science.gov (United States)

    Lane-Donovan, Courtney; Herz, Joachim

    2017-06-01

    The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role this receptor family plays in the CNS. Surprisingly, it was discovered that two LDLR family members, ApoE receptor 2 (Apoer2) and VLDL receptor (Vldlr), play key roles in brain development and adult synaptic plasticity, primarily by mediating Reelin signaling. This review focuses on Apoer2 and Vldlr signaling in the CNS and its role in human disease. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

  5. &apos;K&apos; contribution to the biological effect of ionizing radiations

    International Nuclear Information System (INIS)

    Boissiere, Arnaud

    2004-01-01

    The aim of this work is to determine the importance of &apos;K&apos; ionizations on DNA as critical physical events initiating the biological effects of ionizing radiation, in particular in human cells. Ultra-soft X-rays are used as a probe of core ionization events. A decisive test consists in comparing the biological effects at 250 eV and 350 eV (before and after the carbon K - threshold). The results show a sharp increase of the biological efficiency for both cellular inactivation and chromosomal exchange aberration above the carbon K-threshold, correlated with the one of core events occurring in DNA atoms. The heavy ion irradiation displays again the paradoxical behaviour of cellular inactivation cross sections as a function of LET. Finally, the &apos;K&apos; event contribution to cellular inactivation of usual low LET radiation is estimated to be about 75%. (author) [fr

  6. Human appropriation of net primary production in the United Kingdom, 1800-2000. Changes in society&apos;s impact on ecological energy flows during the agrarian-industrial transition

    Energy Technology Data Exchange (ETDEWEB)

    Musel, Annabella [Institute of Social Ecology, Alpen-Adria University Klagenfurt - Graz - Wien, Schottenfeldgasse 29, 1070 Vienna (Austria)

    2009-12-15

    This paper presents an empirical analysis of the United Kingdom&apos;s society&apos;s long-term intervention into the energy flows of domestic terrestrial ecosystems through the human appropriation of aboveground net primary production (aHANPP) covering the period 1800-2000. The depicted aHANPP trajectory and the historical development of its components are discussed in view of a continuously increasing population and the transition process from an agrarian to an industrial socioecological regime. During the 19th century, aHANPP shows a steady decline from its level of 71% in 1800. While even higher levels were reached during the mid 20th century, the trend during the last forty years of the period under investigation again shows a reduction of aHANPP, which lies at 68% in the year 2000. The high values of aHANPP in the United Kingdom are primarily attributable to the limited amount of forest in comparison to large agricultural areas. At the beginning of the studied period, the relative stabilisation or even decrease in aHANPP in comparison to population development was made possible through the area expansion of and productivity increases on cropland and permanent pastures. Later this was made possible through the outsourcing of biomass harvest, by satisfying local nutritional demands by means of overseas imports, and as from the mid 20th century through huge amounts of fossil fuel based inputs into agriculture (e.g. increased amounts of fertilizers and motorized traction) which allowed increases in biomass harvest to be decoupled from HANPP. (author)

  7. Trends in Energy. &apos;The consumer decides&apos;; Trends in Energy. &apos;De consument bepaalt&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Brzezowsky-Ruys, Y.; Van der Zalm, M.; Van Zutphen, M. (eds.)

    2012-03-15

    A report is given of the Capgemini organised congress &apos;Trends in Energy 2011&apos; which has the Dutch subtitle &apos;De consument bepaalt&apos; (The consumer decides&apos;. The focus of the articles, interviews, debates and presentations is on the role of the consumer in the supply of and demand for energy. Parts of the report are in Dutch and English [Dutch] Dit rapport bestaat uit een verslag van het congres &apos;Trends in Energy 2011. De consument bepaalt&apos; en een aantal artikelen met achtergrondinformatie over onder meer de rol van de consument in vraag en aanbod van energie.

  8. Reduction of the immunostainable length of the hippocampal dentate granule cells&apos; primary cilia in 3xAD-transgenic mice producing human A{beta}{sub 1-42} and tau

    Energy Technology Data Exchange (ETDEWEB)

    Chakravarthy, Balu, E-mail: Balu.Chakravarthy@nrc-cnrc.gc.ca [Human Health Therapeutics, National Research Council of Canada, Ottawa, ON (Canada); Gaudet, Chantal; Menard, Michel; Brown, Leslie; Atkinson, Trevor [Human Health Therapeutics, National Research Council of Canada, Ottawa, ON (Canada); LaFerla, Frank M. [Department of Neurobiology and Behavior, University of California, Irvine, CA (United States); Ito, Shingo [Human Health Therapeutics, National Research Council of Canada, Ottawa, ON (Canada); Armato, Ubaldo; Dal Pra, Ilaria [Department of Life and Reproduction Sciences, University of Verona Medical School, Verona (Italy); Whitfield, James [Human Health Therapeutics, National Research Council of Canada, Ottawa, ON (Canada)

    2012-10-12

    Highlights: Black-Right-Pointing-Pointer A{beta} and tau-induced neurofibrillary tangles play a key role in Alzheimer&apos;s disease. Black-Right-Pointing-Pointer A{beta}{sub 1-42} and mutant tau protein together reduce the primary cilium length. Black-Right-Pointing-Pointer This shortening likely reduces cilium-dependent neurogenesis and memory function. Black-Right-Pointing-Pointer This provides a model of an A{beta}/tau targeting of a neuronal signaling organelle. -- Abstract: The hippocampal dentate gyrus is one of the two sites of continuous neurogenesis in adult rodents and humans. Virtually all dentate granule cells have a single immobile cilium with a microtubule spine or axoneme covered with a specialized cell membrane loaded with receptors such as the somatostatin receptor 3 (SSTR3), and the p75 neurotrophin receptor (p75{sup NTR}). The signals from these receptors have been reported to stimulate neuroprogenitor proliferation and the post-mitotic maturation of newborn granule cells into functioning granule cells. We have found that in 6-24-months-old triple transgenic Alzheimer&apos;s disease model mice (3xTg-AD) producing both A{beta}{sub 1-42} and the mutant human tau protein tau{sub P301L,} the dentate granule cells still had immunostainable SSTR3- and p75{sup NTR}-bearing cilia but they were only half the length of the immunostained cilia in the corresponding wild-type mice. However, the immunostainable length of the granule cell cilia was not reduced either in 2xTg-AD mice accumulating large amounts of A{beta}{sub 1-42} or in mice accumulating only a mutant human tau protein. Thus it appears that a combination of A{beta}{sub 1-42} and tau protein accumulation affects the levels of functionally important receptors in 3xTg-AD mice. These observations raise the important possibility that structural and functional changes in granule cell cilia might have a role in AD.

  9. APOE Genotyping, Cardiovascular Disease

    Science.gov (United States)

    ... Resources For Health Professionals Subscribe Search APOE Genotyping, Cardiovascular Disease Send Us Your Feedback Choose Topic At a ... help understand the role of genetic factors in cardiovascular disease . However, the testing is sometimes used in clinical ...

  10. Aluminum &apos;'egg-box'&apos; panel as an energy absorber for pedestrian protection

    Energy Technology Data Exchange (ETDEWEB)

    Nowpada, Sravanthi; Chirwa, Efford C.; Myler, Peter; Matsika, Emmanuel [Bolton Automotive and Aerospace Research Group (BAARG), School of Built Environment and Engineering, University of Bolton (United Kingdom)

    2010-07-15

    This paper evaluates the quasi-static performance of lightweight aluminum &apos;'egg-box'&apos; panels which have an improved architecture specifically designed to increase the energy absorption capability. In its entirety, the egg-box panel structure investigated herein is made up of arrays of positive and negative frusta. To understand the collapse mechanism and the factors influencing the energy absorption thereof, compressive tests were conducted under similar test conditions on two single frusta, one constrained in situ and the other separated from the egg-box panel exposing the free-free edges. Their load-displacement histories show characteristics that are similar, with a rise in load to a point where they plateau at a steady state load for the entire collapse time. But the energy absorbed by the in situ constrained frustum is 80% greater than that separated from the egg-box panel with free-free edges. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  11. THE LONG-LIVED UV &apos;'PLATEAU'&apos; OF SN 2012aw

    Energy Technology Data Exchange (ETDEWEB)

    Bayless, Amanda J.; Roming, Peter W. A. [Southwest Research Institute, Department of Space Science, 6220 Culebra Road, San Antonio, TX 78238 (United States); Pritchard, Tyler A. [Department of Astronomy and Astrophysics, Penn State University, 525 Davey Lab, University Park, PA 16802 (United States); Kuin, Paul [Mullard Space Science Laboratory, Holmbury St. Mary, Dorking, Surrey RH5 6NT (United Kingdom); Brown, Peter J. [Texas A and M University, Department of Physics and Astronomy, College Station, TX 77843-4242 (United States); Botticella, Maria Teresa; Dall' Ora, Massimo [INAF-Osservatorio Astronomico di Capodimonte, via Moiariello 16, I-80131 Napoli (Italy); Frey, Lucille H.; Even, Wesley; Fryer, Chris L. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Maund, Justyn R.; Fraser, Morgan [Astrophysics Research Center, School of Mathematics and Physics, Queen' s University Belfast, Belfast BT7 1NN (United Kingdom)

    2013-02-10

    Observations with the Swift UV Optical Telescope have unambiguously uncovered for the first time a long-lived, UV &apos;'plateau'&apos; in a Type II-P supernova (SN). Although this flattening in slope is hinted at in a few other SNe, due to its proximity and minimal line-of-sight extinction, SN 2012aw has afforded the first opportunity to clearly observe this UV plateau. The observations of SN 2012aw revealed all Swift UV and u-band light curves initially declined rapidly, but 27 days after the explosion the light curves flattened. Some possible sources of the UV plateau are the same thermal process that causes the optical plateau, heating from radioactive decay, or a combination of both processes.

  12. Porosity. &apos;&apos;The good, the bad and ugly&apos;&apos; of Radiographic Testing

    International Nuclear Information System (INIS)

    Vaughan, Hugo

    2016-01-01

    &apos;&apos;Radiographic Testing is a NDT method to detect inherent volumetric discontinuities in materials such as castings and welds&apos;&apos; A common type of discontinuity found and most often misinterpreted and evaluated is rounded indications, whether isolated, aligned or clustered. This paper addresses the acceptance criteria of rounded indications based on various codes and standards and intends to lay at rest the confusion related to this type of discontinuity. The following are important considerations: 1. Interpretation of rounded indications based on codes and standards used in the various sectors of NDT. 2. What types of discontinuities can be regarded as rounded indications? 3. What discontinuity sizes can be regarded as relevant discontinuities? 4. What are the acceptance and rejection criteria for relevant rounded indications 5. Compiling relevant student assignments to facilitate the proper understanding of this aspect.

  13. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS.

    Directory of Open Access Journals (Sweden)

    Kristin R Wildsmith

    Full Text Available Apolipoprotein E (ApoE is the strongest genetic risk factor for Alzheimer's disease and has been implicated in the risk for other neurological disorders. The three common ApoE isoforms (ApoE2, E3, and E4 each differ by a single amino acid, with ApoE4 increasing and ApoE2 decreasing the risk of Alzheimer's disease (AD. Both the isoform and amount of ApoE in the brain modulate AD pathology by altering the extent of amyloid beta (Aβ peptide deposition. Therefore, quantifying ApoE isoform production and clearance rates may advance our understanding of the role of ApoE in health and disease. To measure the kinetics of ApoE in the central nervous system (CNS, we applied in vivo stable isotope labeling to quantify the fractional turnover rates of ApoE isoforms in 18 cognitively-normal adults and in ApoE3 and ApoE4 targeted-replacement mice. No isoform-specific differences in CNS ApoE3 and ApoE4 turnover rates were observed when measured in human CSF or mouse brain. However, CNS and peripheral ApoE isoform turnover rates differed substantially, which is consistent with previous reports and suggests that the pathways responsible for ApoE metabolism are different in the CNS and the periphery. We also demonstrate a slower turnover rate for CSF ApoE than that for amyloid beta, another molecule critically important in AD pathogenesis.

  14. The &apos;practical elimination&apos; approach of accident situations for water-cooled nuclear power reactors 2017

    International Nuclear Information System (INIS)

    2017-01-01

    The implementation of the defence in depth principle and current regulations have lead applicants to define provisions to prevent accidents, including severe accidents, and to limit their consequences should they occur. However, while defining the design orientations for a new water-cooled power reactor, applicants shall use the &apos;practical elimination&apos; approach for severe accident situations (in the reactor core or the spent fuel pool) potentially leading to large early radiological releases, where it appears impossible to define realistic and demonstrable provisions to limit their consequences according to current knowledge and the techniques available at the time. The use of this approach should be discussed between the applicant and the safety authority at the design orientations stage; the authority will specify on a case-by-case basis the conditions for its approval. In order to &apos;practically eliminate&apos; a situation, the designer shall first examine the possibility for making it physically impossible. Where physical impossibility cannot be achieved, provisions shall be implemented to justify with a high degree of confidence that the situation is extremely unlikely. Situations likely to be &apos;practically eliminated&apos; are diverse (massive and rapid reactivity insertion accidents, explosions, containment bypasses, etc.); the justification of &apos;practical elimination&apos; can only be assessed on a case-by-case basis, using deterministic considerations complemented by a probabilistic analysis. The assessment relies on the reactor physical characteristics as well as on the robustness and reliability of the lines of defence implemented to prevent the situation to be &apos;practically eliminated&apos;. The implemented provisions shall be subject to strong design, manufacturing and operation requirements; considerations related to human factors and hazards shall also be taken into account. This document is an orientation text which defines

  15. A fast and cost-effective method for apolipoprotein E isotyping as an alternative to APOE genotyping for patient screening and stratification.

    Science.gov (United States)

    Calero, Olga; García-Albert, Luis; Rodríguez-Martín, Andrés; Veiga, Sergio; Calero, Miguel

    2018-04-13

    Apolipoprotein E (apoE) is a 34 kDa glycoprotein involved in lipid metabolism. The human APOE gene encodes for three different apoE protein isoforms: E2, E3 and E4. The interest in apoE isoforms is high for epidemiological research, patient stratification and identification of those at increased risk for clinical trials and prevention. The isoform apoE4 is associated with increased risk for coronary heart and Alzheimer's diseases. This paper describes a method for specifically detecting the apoE4 isoform from biological fluids by taking advantage of the capacity of apoE to bind "specifically" to polystyrene surfaces as capture and a specific anti-apoE4 monoclonal antibody as reporter. Our results indicate that the apoE-polystyrene binding interaction is highly stable, resistant to detergents and acid and basic washes. The methodology here described is accurate, easily implementable, fast and cost-effective. Although at present, our technique is unable to discriminate homozygous APOE ε4/ε4 from APOE ε3/ε4 and ε2/ε4 heterozygous, it opens new avenues for the development of inexpensive, yet effective, tests for the detection of apoE4 for patients' stratification. Preliminary results indicated that this methodology is also adaptable into turbidimetric platforms, which make it a good candidate for clinical implementation through its translation to the clinical analysis routine.

  16. Experimental project with &apos;&apos;green fingers&apos;&apos;. A monitoring informs on successes and failures of Helsinki&apos;s Eco-City; Experimentelles Projekt mit &apos;&apos;gruenen Fingern&apos;&apos;. Ein Monitoring gibt Auskunft ueber Erfolge und Misserfolge von Helsinkis &apos;'Oeko-Stadt'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ulf [Kansas State Univ., Manhattan, KS (United States). Sustainable Architecture and Urban Design

    2012-07-01

    Of all things, at the extreme edge of Europe, the future of the European city is being rethought: with the new neighborhood &apos;'Viikki'&apos; the Finnish capital Helsinki has built their first eco-city. Eight years after its completion it is time for an evaluation. The founders draw a quite self-critical summary. The monitoring of Eco-Viikki is unusually accurate and thus gives interesting insights for other construction projects in Europe.

  17. The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles

    DEFF Research Database (Denmark)

    Christoffersen, Christina; Benn, Marianne; Christensen, Pernille Møller

    2012-01-01

    .005) of the initial amounts of human apoM remained in the plasma of Wt and LDL receptor-deficient mice, respectively. Finally, we compared the turnover of radio-iodinated LDL and plasma apoM concentrations in 45 normocholesterolemic humans. There was a negative correlation between plasma apoM and the fractional......ApoM is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL receptor deficiency is associated with increased plasma apoM in mice. Here, we tested the idea that plasma apoM concentrations...... = 0.02, respectively) as compared with noncarriers (0.93 ± 0.04 µM). When we injected human apoM-containing HDL into Wt (n = 6) or LDL receptor-deficient mice (n = 6), the removal of HDL-associated human apoM was delayed in the LDL receptor-deficient mice. After 2 h, 54 ± 5% versus 90 ± 8% (P

  18. Evaluation of the potential of rhTGF- β3 encapsulated P(LLA-CL)/collagen nanofibers for tracheal cartilage regeneration using mesenchymal stems cells derived from Wharton&apos;s jelly of human umbilical cord

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jing; Sun, Binbin [State Key Laboratory of Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620 (China); Tian, Lingling [Center for Nanofibers and Nanotechnology, E3-05-14, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576 (Singapore); He, Xiaomin [Department of Pediatric Cardiothoracic Surgery, Shanghai Children' s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127 (China); Gao, Qiang; Wu, Tong [State Key Laboratory of Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620 (China); Ramakrishna, Seeram [Center for Nanofibers and Nanotechnology, E3-05-14, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576 (Singapore); Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou 510632 (China); Zheng, Jinghao, E-mail: zhengjh210@163.com [Department of Pediatric Cardiothoracic Surgery, Shanghai Children' s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127 (China); Mo, Xiumei, E-mail: xmm@dhu.edu.cn [State Key Laboratory of Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620 (China); Shandong International Biotechnology Park Development Co., Ltd. (China)

    2017-01-01

    Tracheal injuries are one of major challenging issues in clinical medicine because of the poor intrinsic ability of tracheal cartilage for repair. Tissue engineering provides an alternative method for the treatment of tracheal defects by generating replacement tracheal structures. In this study, core-shell nanofibrous scaffold was fabricated to encapsulate bovine serum albumin & rhTGF-β3 (recombinant human transforming growth factor-β3) into the core of the nanofibers for tracheal cartilage regeneration. Characterization of the core-shell nanofibrous scaffold was carried out by scanning electron microscope (SEM), transmission electron microscope (TEM), laser scanning confocal microscopy (LSCM), and tensile mechanical test. The rhTGF-β3 released from the scaffolds in a sustained and stable manner for about 2 months. The bioactivity of released rhTGF-β3 was evaluated by its effect on the synthesis of type II collagen (COL2) and glycosaminoglycans (GAGs) by chondrocytes. The results suggested that its bioactivity was retained during release process. The proliferation and morphology analyses of mesenchymal stems cells derived from Wharton&apos;s jelly of human umbilical cord (WMSCs) indicated the good biocompatibility of the fabricated nanofibrous scaffold. Meanwhile, the chondrogenic differentiation of WMSCs cultured on core-shell nanofibrous scaffold was evaluated by real-time qPCR and histological staining. The results suggested that the core-shell nanofibrous scaffold with rhTGF-β3 could promote the chondrogenic differentiation ability of WMSCs. Therefore, WMSCs could be a promising seed cells in the construction of tissue-engineered tracheal cartilage. Overall, the core-shell nanofibrous scaffold could be an effective delivery system for rhTGF-β3 and served as a promising tissue engineered scaffold for tracheal cartilage regeneration. - Highlights: • rhTGF-β3 could be encapsulated into core-shell nanofibers via electrospinning. • rhTGF-β3 could release

  19. Switzerland as Europe&apos;s &apos;'battery'&apos;. Wishful dream or reality?; Die Schweiz als &apos;&apos;Batterie Europas&apos;&apos;. Utopie oder Realitaet?

    Energy Technology Data Exchange (ETDEWEB)

    Kammer, Adrian; Zurmuehle, Damian; Salzmann, Michael; Baumgartner, Raphael; Mignone, Domenico [Bernische Kraftwerke (BKW), Bern (Switzerland). Energiewirtschaftliche Planung und Prognose

    2015-04-15

    There are plans for Swiss pumped hydrostorage systems to absorb large quantities of excess electricity from European wind and solar power generation. Model-based analyses have shown however that &apos;'Europe&apos;s battery&apos;&apos;, as Switzerland would like to see itself, will not be needed until the middle of this century. Even if all extension projects currently in progress should be completed, Switzerland will not have sufficient pump capacity or import capacity to absorb large amounts of excess electricity. Furthermore, the primary means of making storage capacity available for import electricity would be to reduce reservoir power plant capacity. In view of all this Switzerland&apos;s hopes for a role as a major European electricity storage provider appear somewhat exaggerated even in the long-term perspective.

  20. A Case Study of Human Resource Development Professionals&apos; Decision Making in Vendor Selection for Employee Development: A Degrees-of-Freedom Analysis

    Science.gov (United States)

    Cathcart, Stephen Michael

    2016-01-01

    This mixed method study examines HRD professionals' decision-making processes when making an organizational purchase of training. The study uses a case approach with a degrees of freedom analysis. The data to analyze will examine how HRD professionals in manufacturing select outside vendors human resource development programs for training,…

  1. LLNL&apos;s Big Science Capabilities Help Spur Over $796 Billion in U.S. Economic Activity Sequencing the Human Genome

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Jeffrey S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-07-28

    LLNL’s successful history of taking on big science projects spans beyond national security and has helped create billions of dollars per year in new economic activity. One example is LLNL’s role in helping sequence the human genome. Over $796 billion in new economic activity in over half a dozen fields has been documented since LLNL successfully completed this Grand Challenge.

  2. New quality assurance program integrating &apos;&apos;modern radiotherapy&apos;&apos; within the German Hodgkin Study Group

    Energy Technology Data Exchange (ETDEWEB)

    Kriz, J.; Haverkamp, U.; Eich, H.T. [University of Muenster, Department of Radiation Oncology, Muenster (Germany); Baues, C.; Marnitz-Schulze, S. [University of Cologne, Department of Radiation Oncology, Koeln (Germany); Engenhart-Cabillic, R. [University of Marburg, Department of Radiation Oncology, Marburg (Germany); Herfarth, K. [University of Heidelberg, Department of Radiation Oncology, Heidelberg (Germany); Lukas, P. [University of Innsbruck, Department of Radiation Oncology, Innsbruck (Austria); Schmidberger, H. [University of Mainz, Department of Radiation Oncology, Mainz (Germany); Fuchs, M.; Engert, A. [University of Cologne, Department of Internal Medicine, Koeln (Germany)

    2017-02-15

    Field design changed substantially from extended-field RT (EF-RT) to involved-field RT (IF-RT) and now to involved-node RT (IN-RT) and involved-site RT (IS-RT) as well as treatment techniques in radiotherapy (RT) of Hodgkin&apos;s lymphoma (HL). The purpose of this article is to demonstrate the establishment of a quality assurance program (QAP) including modern RT techniques and field designs within the German Hodgkin Study Group (GHSG). In the era of modern conformal RT, this QAP had to be fundamentally adapted and a new evaluation process has been intensively discussed by the radiotherapeutic expert panel of the GHSG. The expert panel developed guidelines and criteria to analyse &apos;'modern'&apos; field designs and treatment techniques. This work is based on a dataset of 11 patients treated within the sixth study generation (HD16-17). To develop a QAP of &apos;&apos;modern RT&apos;&apos;, the expert panel defined criteria for analysing current RT procedures. The consensus of a modified QAP in ongoing and future trials is presented. With this schedule, the QAP of the GHSG could serve as a model for other study groups. (orig.) [German] Nicht nur die Zielvolumendefinitionen haben sich von der Extended-Field- (EF-RT) ueber die Involved-Field- (IF-RT) bis zur Involved-Node- (IN-RT) und Involved-Site-Radiotherapie (IS-RT) weiterentwickelt. Auch die Radiotherapie(RT)-Techniken in der Behandlung von Patienten mit Hodgkin-Lymphom haben Aenderungen erfahren. Wir moechten aufzeigen, wie die Arbeit des Qualitaetssicherungsprogramms (QAP) innerhalb der Deutschen Hodgkin Studiengruppe (German Hodgkin Study Group [GHSG]) in der Aera der &apos;&apos;modernen RT&apos;&apos; hinsichtlich intensitaetsmodulierter RT (IMRT) und bildgefuehrter RT (IGRT), aber auch hinsichtlich moderner Felddefinitionen wie bei der IN-RT angepasst wurde. In der Aera der &apos;&apos;modernen RT&apos;&apos; wurde das QAP vom radiotherapeutischen Expertenpanel der GHSG im Rahmen einiger

  3. From human error to organizational failure: a historical perspective; De l&apos;erreur humaine a la defaillance organisationnelle: essai de mise en perspective historique

    Energy Technology Data Exchange (ETDEWEB)

    Guarnieri, F. [Mines ParisTech, 75 - Paris (France); Cambon, J. [Centre de Recherche sur les Risques et les Crises (CRC), 75 - Paris (France); Boissieres, I. [Institut pour une Culture de Securite Industrielle (ICSI), 31 - Toulouse (France)

    2008-09-15

    This article hinges around three main parts.The first part goes back over the foundations of the human factor approach. It introduces the basic assumptions as well as some of the methods which have been developed. The second part accounts for the reasons why organizational factors have drawn our attention at the first place underlying two major points: the limits of the human factor approach but also the original contribution and the innovative aspect of sociology. At last, the third part describes the keystone principles and hypotheses on which lay the foundations of the organizational factor approach and draws a brief overview of the methods which have lately been implanted within the industrial world. (authors)

  4. Design of a phantom equivalent to measure bone-fluorine in a human&apos;s hand via delayed neutron activation analysis

    International Nuclear Information System (INIS)

    Mostafaei, F; McNeill, F E; Chettle, D R; Prestwich, W V; Inskip, M

    2013-01-01

    Fluorine is an element that can be either beneficial or harmful, depending on the total amount accumulated in the teeth or bones. In our laboratory, we have developed a non-invasive technique for the in vivo measurement of fluoride in bone using neutron activation analysis and performed the first pilot human study. Fluoride in humans is quantified by comparing the γ-ray signal from a person to the γ-ray signal obtained from appropriate anthropomorphic calibration phantoms. An identified problem with existing fluoride phantoms is contamination with aluminum. Aluminum creates an interfering γ-ray signal which, although it can be subtracted out, increases the uncertainty in the measurement and worsens the detection limit. This paper outlines a series of studies undertaken to develop a better calibration phantom for fluorine measurement, which does not have aluminum contamination. (paper)

  5. Proceedings of the DGMK-conference &apos;Synthesis gas chemistry&apos;. Authors&apos; manuscripts

    Energy Technology Data Exchange (ETDEWEB)

    Hoenicke, D.; Kohlpaintner, C.; Luecke, B.; Reschetilowski, W. [eds.

    2000-07-01

    The main topics of the DGMK-Conference &apos;&apos;Synthesis Gas Chemistry&apos;&apos; were: production of synthesis gas from several educts, new catalysts, Fischer-Tropsch synthesis, hydroformylation, steam reforming and carbonylation.

  6. Bookshelf (&apos;&apos;Neutrons, Nuclei and Matter&apos;&apos;, by J. Byrne)

    International Nuclear Information System (INIS)

    Hansen, P.G.

    1994-01-01

    Time was when a neophyte wanting to do experiments with neutrons would be told first to read D.J. Hughes&apos; classic &apos;&apos;Pile Neutron Research&apos;&apos; (1952). The book by J. Byrne is in many respects a modern equivalent, although if you were to send your student away with it, you will risk not seeing him or her again for a considerable time. What is immediately striking is that the book, rich in information and quite long, is cross-disciplinary and touches essentially all the main areas of modern physics. It covers parts of particle physics, such as the internal structure of the neutron, time-reversal violation as revealed by the (still hypothetical) electric dipole moment of the neutron, and the coupling constants for the weak interaction. From the field of basic quantum physics there are chapters on neutron optics, wave phenomena with neutrons and on the applications of these in solid-state physics. Other chapters again delve deeply into nuclear structure, nuclear reaction theory, as well as their applications: nuclear reactors and nuclear energy. At a time with specialization rampant and many physicists tending to believe that venturing outside their own cloisters is uninteresting and even dangerous, it is a pleasure to come across a book that is basically just about physics. J. Byrne of Sussex has for long been active in neutron research at the British-French-German Institut Laue-Langevin (ILL) research reactor in Grenoble, where he has worked on subjects such as weak interactions and fundamental symmetries. He has clearly intended &apos;&apos;Neutrons, Nuclei and Matter&apos;&apos; as a vade-mecum that will allow the practitioner to find the necessary information and formulas. But I believe that many others not directly engaged in neutron research will gain new insight from its many examples. To take just one case, I had not been aware of the simple physical principles that permit cold neutrons to be stored in a bottle. (The main point is that a

  7. High-sensitivity gamma spectroscopy for extended sources. Application to activity measurements on the human body, on glass, and on soil; Spectrographie gamma a grande sensibilite pour sources etendues. Application a la mesure de l&apos;activite du corps humain, du verre et du sol

    Energy Technology Data Exchange (ETDEWEB)

    Jouve, B

    1962-07-01

    The measurement and location by gamma spectroscopy of human body internal contaminations at maximum permissible levels, and, in certain cases, at lower activities such as that due to {sup 40}K was investigated. The characteristics of the high-sensitivity apparatus used are given, and several assemblies using large-volume NaI(Tl) scintillators are described. The relatively light shielding required for natural radioactivity permitted construction of mobile assembly. Conditions of use are described, and the results are given. All gamma emitting elements were measured in 15 min at levels lower than the tolerance dose. Gamma spectroscopy was also used to determine fission products in the earth and to study radioactive elements in the presence of other emitters. (author) [French] La spectrographie gamma du corps humain permet la mesure et la localisation des contaminations internes au niveau des doses de tolerance et, dans certains cas, celle d&apos;activites plus faibles comme la radioactivite naturelle due principalement au potassium 40. Les caracteristiques des appareils a grande sensibilite permettant ces mesures sont exposees et on decrit plusieurs realisations originales utilisant un scintillateur NaI(Tl) de grand volume. L&apos;epaisseur du blindage a ete limitee a 5 cm de plomb, ainsi, pour une protection suffisante contre les rayonnements ambiants, les appareils sont relativement legers et l&apos;une des realisations a pu etre installee dans un laboratoire mobile. Les conditions d&apos;utilisation (mouvement propre, etalonnage) et les resultats obtenus sont donnes; tous les radioelements emetteurs gamma sont mesurables en 15 minutes a un niveau inferieur a la dose de tolerance. On presente enfin des applications a la spectrographie gamma d&apos;echantillons volumineux (poudres ou liquides) et de tres faible activite: elles interessent des domaines tres varies comme, par exemple, la geophysique (etude des retombees radioactives) ou l&apos;industrie chimique

  8. Financial and tax risks at implementation of &apos;&apos;Chayanda- Lensk&apos;&apos; section of &apos;&apos;Sila Sibiri&apos;&apos; gas transportation system construction project

    International Nuclear Information System (INIS)

    Sharf, I V; Chukhareva, N V; Kuznetsova, L P

    2014-01-01

    High social and economic importance of large-scale projects on gasification of East Siberian regions of Russia and diversifying gas exports poses the problem of complex risk analysis of the project. This article discusses the various types of risks that could significantly affect the timing of the implementation and effectiveness of the project for the construction of the first line of &apos;&apos;Sila Sibiri&apos;&apos;, the &apos;'Chayanda-Lensk'&apos; section. Special attention is paid to financial and tax aspects of the project. Graphically presented analysis of the dynamics of financial indicators reflect certain periods of effectiveness in implementing the project. Authors also discuss the possible causes and consequences of risks

  9. The human dorsal spinocerebellar tract: myelinated fiber spectrum and fiber density in controls, autosomal dominant spinocerebellar atrophy, Huntington&apos;s chorea, radiation myelopathy, and diseases with peripheral sensory nerve involvement

    Energy Technology Data Exchange (ETDEWEB)

    Ringelstein, E.B.; Schroeder, J.M.

    1982-01-01

    The human dorsal spinocerebellar tract (DSCT) was evaluated morphometrically in 14 control cases of different age and sex using semithin sections of epon-embedded cross sections from the C3, T5, and T10 segments of the spinal cord. A bimodal fiber spectrum was revealed with one peak at 2-3 microns, and a second, broader peak at about 6-8 microns. Fiber density at C3 was 11,188 fibers/mm2 and at T5, 11,156 fibers/mm2. Regression analysis relating fiber density to age disclosed a highly significant loss of myelinated fibers at T5 amounting to about 2.5% per decade. A severe reduction of fiber density and a distinct change in the fiber spectrum with predominant loss of large myelinated fibers were noted in a case of autosomal dominant spinocerebellar atrophy with late onset, and, to a lesser degree, in a case of Huntington&apos;s chorea. A subtotal loss of fibers with a persistent normal distribution of fiber sizes was observed rostral to a focus of severe radiation myelopathy, indicating Wallerian degeneration of large numbers of fibers, and a reduction of fiber diameters caudal to the lesion, suggesting retrograde fiber change. By contrast, no primary or transneural changes in the DSCT were detected in six cases of long-term alcoholism, carcinomatous sensory neuropathy, and neurofibromatosis in spite of the involvement of numerous nerve roots.

  10. The best selled car. &apos;'Twizy'&apos; leads the sales statistics of electrically powered vehicles - a test report; Der Meistverkaufte. Renaults &apos;'Twizy'&apos; fuehrt die E-Mobil-Verkaufsstatistik an - ein Fahrbericht

    Energy Technology Data Exchange (ETDEWEB)

    Welter, Philippe

    2013-02-15

    Four wheels, two seats, one steering wheel: What does it require more for a small, electrically powered city car? Nothing, says the manufacturer. Two side windows, that is our opinion. With a maximum speed of 80 kilometers per hour and a range of 100 kilometers, the vehicle is certainly ideal for many applications over short distances in the city. PHOTON now uses the &apos;'Twizy'&apos; for almost a year, and gained consistently good experiences.

  11. &apos;&apos;Is it really green?&apos;&apos; Long-term performance of monocrystalline solar modules as illustrated by the example of a photovoltaic pumping station in a natural reserve (&apos;&apos;Schwenninger Moos&apos;&apos;); &apos;&apos;Is it really green?&apos;&apos; Langzeiterfahrung mit monokristallinen Solarmodulen am Beispiel der photovoltaischen Pumpstation Schwenninger Moos

    Energy Technology Data Exchange (ETDEWEB)

    Assbeck, Franz [Hochschule Furtwangen (Germany). Fakultaet Computer und Electrical Engineering

    2010-03-15

    In 1991, a photovoltaic pumping station was commissioned in the natural reserve &apos;&apos;Schwenninger Moos&apos;&apos; in the southern Black Forest. The pumping station was dismantled when the land was used for the 2010 Baden-Wuerttemberg &apos;Landesgartenschau&apos; (garden festival). After 18 years of operation, the plant provided valuable information on the long-term performance of monocrystalline solar modules, so the author made detailed measurements and evaluations just before the plant was dismantled, in an attempt to find out about its long-term performance and cost efficiency. The results are presented here. (orig.)

  12. Network protocol &apos;EPAP&apos;; Network protokoru &apos;EPAP&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kobori, T.; Fujita, F.; Iwamoto, S. [Fuji Electric Co. Ltd., Toyo (Japan)

    2000-10-10

    The Ethernet, a standard of information networks, has begun to be applied to the control local area network (LAN). To apply the Ethernet to the field level, Fuji Electric has newly developed the communication protocol &apos;Ethernet precision access protocol (EPAP)&apos; in which a command/response method is structured on the user datagram protocol (UDP) to realize real time and high reliability. Further, we have implemented the EPAP on the bus interface module of the open PIO. This paper outlines the EPAP and its implementation. (author)

  13. Progress Report: DE-FG03-97ER20274, &apos;&apos;Microbial Production of Isoprene&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Ray Fall

    2002-03-13

    We have discovered that microorganisms produce and emit the hydrocarbon isoprene (2-methyl-1,3-butadiene), and have suggested that if isoprene-producing enzymes and their genes can be harnessed, useful hydrocarbon-producing systems might be constructed. The main goal of the proposed work is to establish the biochemical mechanism and regulation of isoprene formation in the bacterial system, Bacillus subtilis. Specific objectives of the proposed work are the following: (A) to characterize the physiological regulation of isoprene formation in B. subtilis; (B) to characterize mutations in B. subtilis 168 that suppress isoprene formation, clone these genes, and determine how isoprene and isoprenoid carbon flow are regulated; and (C) to test &apos;'overflow'&apos; and &apos;'signaling'&apos; models for Bacillus isoprene formation. We are also pursuing the isolation and cloning of B. subtilis isoprene synthase, which we believe may be a regulatory enzyme.

  14. Design and implementation of a &apos;'cheese'&apos; phantom-based Tomotherapy TLD dose intercomparison

    Energy Technology Data Exchange (ETDEWEB)

    Schiefer, Hans; Buchauer, Konrad; Heinze, Simon [Medical Physics Group, Department of Radiation Oncology, St. Gallen (Switzerland); Henke, Guido; Plasswilm, Ludwig [Department of Radiation Oncology, St. Gallen (Switzerland)

    2015-11-15

    The unique beam-delivery technique of Tomotherapy machines (Accuray Inc., Sunnyvale, Calif.) necessitates tailored quality assurance. This requirement also applies to external dose intercomparisons. Therefore, the aim of the 2014 SSRMP (Swiss Society of Radiobiology and Medical Physics) dosimetry intercomparison was to compare two set-ups with different phantoms. A small cylindrical Perspex phantom, which is similar to the IROC phantom (Imaging and Radiation Oncology Core, Houston, Tex.), and the &apos;'cheese'&apos; phantom, which is provided by the Tomotherapy manufacturer to all institutions, were used. The standard calibration plans for the TomoHelical and TomoDirect irradiation techniques were applied. These plans are routinely used for dose output calibration in Tomotherapy institutions. We tested 20 Tomotherapy machines in Germany and Switzerland. The ratio of the measured (D{sub m}) to the calculated (D{sub c}) dose was assessed for both phantoms and irradiation techniques. The D{sub m}/D{sub c} distributions were determined to compare the suitability of the measurement set-ups investigated. The standard deviations of the TLD-measured (thermoluminescent dosimetry) D{sub m}/D{sub c} ratios for the &apos;'cheese'&apos; phantom were 1.9 % for the TomoHelical (19 measurements) and 1.2 % (11 measurements) for the TomoDirect irradiation techniques. The corresponding ratios for the Perspex phantom were 2.8 % (18 measurements) and 1.8 % (11 measurements). Compared with the Perspex phantom-based set-up, the &apos;'cheese'&apos; phantom-based set-up without individual planning was demonstrated to be more suitable for Tomotherapy dose checks. Future SSRMP dosimetry intercomparisons for Tomotherapy machines will therefore be based on the &apos;'cheese'&apos; phantom set-up. (orig.) [German] Die einzigartige Bestrahlungstechnik mit Tomotherapie-Bestrahlungsgeraeten (Accuray Inc., Sunnyvale, CA, USA) erfordert spezifische

  15. Environmental and safety aspects. The best of &apos;powder handling and processing&apos; 1989 - 1997. &apos;Bulk solids handling&apos; 1992 - 1997 (H/2000)

    Energy Technology Data Exchange (ETDEWEB)

    Woehlbier, R.H. (ed.)

    2000-07-01

    The book contains articles published either during 1992-1997 in &apos;&apos;bulk solids handling&apos;&apos; or during 1989-1997 in &apos;&apos;powder handling and processing&apos;&apos;. Main topics are aspects of safety and environmental protection in bulk solids handling: dusts, hazardous powders, prevention and mitigation of dust explosions, powdered coal handling, dedusting, filters, electrostatic precipitation, materials recovery, occupational safety.(uke)

  16. &apos;Minergie&apos; as an opportunity for trade; &apos;Minergie&apos; als Chance fuer das Gewerbe

    Energy Technology Data Exchange (ETDEWEB)

    Graf, R.; Buergi, H.; Hotz, R.

    2000-07-01

    This collection of short articles is dedicated to the promotion of the Swiss &apos;Minergie&apos; building standard, covering the following points: &apos;Minergie&apos; - a standard for the future; well-insulated and air-tight - two of the three main &apos;Minergie&apos; requirements; solar collectors as a &apos;Minergie&apos; component; radiators for low-energy-consumption buildings; hot water from the sun on six out of seven days; the &apos;Minergie&apos; module as a factor for success; the &apos;Habitus&apos; ventilation unit - a new Swiss product. The first contribution introduces the &apos;Minergie&apos; Standard. Its application in the building and building technical services trades offers from considerable advantages and opportunities for profit. The Standard, which aims to increase the comfort and reduce the energy consumption of buildings, is introduced and the basic principles involved, including energy usage figures, are discussed. A second contribution describes two of the three main requirements for reaching the &apos;Minergie&apos; Standard, air-tightness and good thermal insulation. The main advantage of the standard - a higher level of comfort - is emphasised and an example is given. The third short article takes a look at the use of thermal solar collectors as a source of heat in &apos;Minergie&apos; buildings. A solution involving a combined solar heating and hot-water supply is discussed. The fourth contribution discusses the use of low-temperature radiators in &apos;Minergie&apos; buildings. Examples are given of heat requirements calculation and the factors involved in dimensioning the radiators are discussed. A fifth article describes a commercially available compact solar hot-water system and discusses questions of solar fraction. Returning to basic aspects, the sixth contribution introduces a labelling system for the various components of a &apos;Minergie&apos; building - such as ventilation units, insulation material, radiators, boilers etc

  17. &apos;Chaos&apos; in superregenerative receivers

    Energy Technology Data Exchange (ETDEWEB)

    Commercon, Jean-Claude [INSA, Department d' Informatiques, Ba-hat t B. Pascal, 20 Avenue Albert Einsten, 69621 Villeurbaune (France)]. E-mail: jean-claude.commercon@insa-lyon.fr; Badard, Robert [INSA, Department d' Informatiques, Bat B. Pascal, 20 Avenue Albert Einsten, 69621 Villeurbaune (France)]. E-mail: robert.badard@insa-lyon.fr

    2005-02-01

    The superregenerative principle has been known since the early 1920s. The circuit is extremely simple and extremely sensitive. Today, superheterodyne receivers generally supplant superregenerative receivers in most applications because there are several undesirable characteristics: poor selectivity, reradiation, etc. Superregenerative receivers undergo a revival in recent papers for wireless systems, where low cost and very low power consumption are relevant: house/building meters (such as water, energy, gas counter), personal computer environment (keyboard, mouse), etc. Another drawback is the noise level which is higher than that of a well-designed superheterodyne receiver; without an antenna input signal, the output of the receiver hears in an earphone as a waterfall noise; this sound principally is the inherent input noise amplified and detected by the circuit; however, when the input noise is negligible with respect of an antenna input signal, we are faced to an other source of &apos;noise&apos; self-generated by the superregenerative working. The main objective of this paper concerns this self-generated noise coming from an exponential growing followed by a re-injection process for which the final state is a function of the phase of the input signal.

  18. How to recover credibility of nuclear technologies in Japan where people wish to have &apos;Anshin&apos;

    International Nuclear Information System (INIS)

    Yasui, Itaru

    2014-01-01

    Although it is inevitable to recover credibility of utilities, there are no clear ways to realize a final target yet. Credibility issue is a very difficult especially in Japan, where the word of &apos;Anshin&apos; has special importance in the mind of people. In this paper, the word of &apos;Anshin&apos; in Japan was discussed in order to find out differences in other countries by comparison of culture and customs, especially ways to prepare food, i.e. agriculture and hunting and gathering and so on. The meanings of &apos;Anshin&apos; were decomposed into several elements, and each element was discussed and clarified. Human factor is important in both operation of plants and risk communication. The philosophy and attitude of COE of utilities are those of very important factors to regain credibility. The utilities&apos; responsibilities are important, but not enough by themselves. In order to assure transparency of information used in risk communication, improvement of people&apos;s scientific literacy and their attitude to elect their representatives are absolutely necessary. Especially, risk information related to Level 3 RPA to be opened to public have to be fully transparent. Risk is one of most difficult concept for Japanese people to handle. The reoperation issue of nuclear power plants will involve several difficulties, but challenges to overcome this issue will be a good chance to change a way of decision making in Japan. (author)

  19. Regulation imposed to nuclear facility operators for the elaboration of &apos;waste studies&apos; and &apos;waste statuses&apos;; Reglementation imposee aux exploitants d&apos;installations nucleaires pour l&apos;elaboration &apos;&apos;des etudes dechets&apos;&apos; et &apos;&apos;des bilans dechets&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-04

    This decision from the French authority of nuclear safety (ASN) aims at validating the new versions of the guidebook for the elaboration of &apos;waste studies&apos; for nuclear facilities and of the specifications for the elaboration of &apos;waste statuses&apos; for nuclear facilities. This paper includes two documents. The first one is a guidebook devoted to nuclear facility operators which fixes the rules of production of waste studies according to the articles 20 to 26 of the inter-ministry by-law from December 31, 1999 (waste zoning conditions and ASN&apos;s control modalities). The second document concerns the specifications for the establishment of annual waste statuses according to article 27 of the inter-ministry by-law from December 31, 1999 (rational management of nuclear wastes). (J.S.)

  20. In vitro metabolism of 2,2&apos;,3,4&apos;,5,5&apos;,6-heptachlorobiphenyl(CB187) with liver microsomes of rats, hamsters and guinea pigs

    Energy Technology Data Exchange (ETDEWEB)

    Koga, N.; Ohta, C.; Kanamaru, T. [Nakamura Gakuen Univ., Fukuoka (Japan); Haraguchi, K. [Daiichi Coll. of Pharmaceutical Sciences, Fukuoka (Japan); Kato, Y.; Yamada, S. [Univ. of Shizuoka, Shizuoka (Japan)

    2004-09-15

    PCB congeners possess extremely high lipophilicity and biological stability, and as a result they are not easily eliminated from the body once ingested. In particular, not only 2,4,5-trichlorosubstituted but also 6 or more chlorine-substituted PCBs such as 2,2&apos;,3&apos;,4,4&apos;,5-hexa-chlorobiphenyl (hexaCB) (CB138), 2,2&apos;,4,4&apos;,5,5&apos;-hexaCB (CB153), 2,2&apos;,3,4,4&apos;,5,5&apos;-heptachloro-biphenyl (heptaCB) (CB180) and 2,2&apos;,3,4&apos;,5,5&apos;,6-heptaCB (CB187) have been detected in blood and adipose tissues of mammals and human mother&apos;s milk at higher concentration. In addition, the 4-hydroxy (OH)-metabolite of CB187 has been reported to be present in human blood at the highest concentration of that derived from other PCB congeners. Although CB187, a tri-ortho-PCB, is one of the minor component in the commercial PCB preparations such as Clophen, Aroclor and Kanechlor, the toxic equivalency factor (TEF) which is used for dioxin-like PCB congeners including coplanar-PCBs and mono-ortho-PCBs to assess the potency of the toxicity has not been set up for di- and tri-ortho-PCB congeners. These facts indicate that 4-OH-PCB187 become more persistent and more important toxicologically than the parent CB187. However, there is little report about biotransformation in vivo or in vitro of CB187 in animals. Therefore, we examined CB187 metabolism by liver microsomes of rats, hamsters and guinea pigs.

  1. Internet of &apos;'printed'&apos; Things: low-cost fabrication of autonomous sensing nodes by inkjet printing

    International Nuclear Information System (INIS)

    Kawahara, Yoshihiro

    2014-01-01

    &apos;&apos;What if electronics devices are printed using an inkjet printer even at home?&apos;&apos; &apos;&apos;What if those devices no longer need a battery?&apos;&apos; I will introduce two enabling technologies for the Internet of Things concept. 1. Instant Inkjet Circuits: A low cost, fast and accessible technology to support the rapid prototyping of electronic devices. We demonstrated that &apos;'sintering-free'&apos; silver nano particle ink with a commodity inkjet printer can be used to fabricate printed circuit board and high-frequency applications such as antennas and sensors. The technology is now commercialized by AgIC, Inc. 2. Wireless Power: Although large amounts of data can be exchanged over a wireless communication link, mobile devices are still tethered by power cables. We are trying to solve this problem by two different approaches: energy harvesting. A simple circuitry comprised of diodes and capacitor can convert ambient radio signals into DC current. Our research revealed the signals from TV tower located 6.5km apart could be used to feed 100 microwatts to power microcontrollers

  2. The global market, that&apos;s the intention; Der Weltmarkt ist das Ziel

    Energy Technology Data Exchange (ETDEWEB)

    Kublik, F. [Shell Solar (Global), Amsterdam (Netherlands); Deutsche Shell AG, Hamburg (Germany). Bereich Regenerative Energien

    2000-07-01

    The author of the paper is Dr. Frithjof Kublik, Vice President of Shell Solar (Global) and division manager &apos;Renewable Energies&apos; of the German Shell AG. He discusses very comprehensively the results of a study performed on behalf of the Shell company. The study encompasses two scenarios based on the same predicted growth of the global human population from 1999 until 2060, and the resulting global demand for energy, but assuming different levels of market penetration and technological development of power generation from RES. Their respective final energy balance statements are very different. The scenario &apos;sustainable development&apos; predicts market shares of renewable energy sources up to 50% of global demand, whereas the scenario &apos;dematerialization&apos; predicts a maximum of 30%. (orig./CB) [German] Der Beitrag erlaeutert eine Studie der Firma Shell AG, die zwei Szenarien - &apos;Nachhaltiges Wachstum&apos; und &apos;Dematerialisierung&apos;- umfasst. Beide Szenarien gehen von der gleichen Bevoelkerungsentwicklung (zehn Milliarden Menschen im Jahre 2060, gegenueber fuenf Milliarden in 1990) und von dem gleichem Wirtschaftswachstum (drei Prozent pro Jahr) aus, die Energiebilanz sieht jedoch unterschiedlich aus. In beiden Szenarien werden sich die regenerativen Energien im Rahmen eines Reifeprozesses weiterentwickeln, indem sie zunaechst Marktnischen besetzen und sich dann mit unterschiedlichem Erfolg im Markt durchsetzen. Im Szenario &apos;Nachhaltiges Wachstum&apos; geht die Studie davon aus, dass Produktivitaetsfortschritte bei der Energiebereitstellung zu einem erheblichen Angebot an regenerativen Energietraegern fuehren wird (bis zu 50% des Weltbedarfs). (orig./CB)

  3. Natural uranium toxicology - evaluation of internal contamination in man; Toxicologie de l&apos;uranium naturel - essai d&apos;evaluation de la contamination interne chez l&apos;homme

    Energy Technology Data Exchange (ETDEWEB)

    Chalabreysse, J. [Commissariat a l' Energie Atomique, Pierrelatte (France). Centre d' Etudes Nucleaires

    1968-07-01

    After reminding the physical and chemical properties of natural uranium which might affect its toxicology, a comprehensive investigation upon natural uranium metabolism and toxicity and after applying occupational exposure standards to this particular poison, it has been determined, from accident reports and human experience reported in the related literature, a series of formulae obtained by theoretical mathematical development giving principles for internal contamination monitoring and disclosure by determining uranium in the urine of occupationally exposed individuals. An assay is performed to determine individual internal contamination according to the various contamination cases. The outlined purposes, mainly practical, required some options and extrapolations. The proposed formula allows a preliminary approach and also to determine shortly a contamination extent or to discuss the systematical urinalysis results as compared with individual radio-toxicology monitoring professional standards. (author) [French] Apres le rappel des caracteristiques physiques et des proprietes chimiques de l&apos;uranium naturel pouvant avoir une influence sur sa toxicologie, l&apos;etude detaillee de son metabolisme et de sa toxicite, puis l&apos;application des normes professionnelles d&apos;exposition au cas particulier de ce toxique, il est etabli, a partir des comptes rendus d&apos;accidents et de l&apos;experimentation humaine rapportes dans la litterature, une serie de formules obtenues par developpement mathematique theorique qui posent les principes de la surveillance et de la mise en evidence de la contamination interne par la recherche et le dosage de l&apos;uranium dans les urines d&apos;individus professionnellement exposes. Un essai d&apos;evaluation de la contamination interne individuelle suivant les differents cas de contamination est effectue. Le formulaire propose permet de faire une premiere approximation et d&apos;apprecier rapidement l&apos;importance d&apos

  4. &apos;&apos;1/f noise&apos;&apos; in music: Music from 1/f noise

    Energy Technology Data Exchange (ETDEWEB)

    Voss, R.F.; Clarke, J.

    1978-01-01

    The spectral density of fluctuations in the audio power of many musical selections and of English speech varies approximately as 1/f (f is the frequency) down to a frequency of 5 x 10/sup -4/ Hz. This result implies that the audio-power fluctuations are correlated over all times in the same manner as &apos;&apos;1/f noise&apos;&apos; in electronic components. The frequency fluctuations of music also have a 1/f spectral density at frequencies down to the inverse of the length of the piece of music. The frequency fluctuations of English speech have a quite different behavior, with a single characteristic time of about 0.1 s, the average length of a syllable. The observations on music suggest that 1/f noise is a good choice for stochastic composition. Compositions in which the frequency and duration of each note were determined by 1/f noise sources sounded pleasing. Those generated by white-noise sources sounded too random, while those generated by 1/f/sup 2/ noise sounded too correlated.

  5. &apos;'Spin-dependent'&apos; μ → e conversion on light nuclei

    International Nuclear Information System (INIS)

    Davidson, Sacha; Saporta, Albert; Kuno, Yoshitaka

    2018-01-01

    The experimental sensitivity to μ → e conversion will improve by four or more orders of magnitude in coming years, making it interesting to consider the &apos;'spin-dependent'&apos; (SD) contribution to the rate. This process does not benefit from the atomic-number-squared enhancement of the spin-independent (SI) contribution, but probes different operators. We give details of our recent estimate of the spin-dependent rate, expressed as a function of operator coefficients at the experimental scale. Then we explore the prospects for distinguishing coefficients or models by using different targets, both in an EFT perspective, where a geometric representation of different targets as vectors in coefficient space is introduced, and also in three leptoquark models. It is found that comparing the rate on isotopes with and without spin could allow one to detect spin-dependent coefficients that are at least a factor of few larger than the spin-independent ones. Distinguishing among the axial, tensor and pseudoscalar operators that induce the SD rate would require calculating the nuclear matrix elements for the second two. Comparing the SD rate on nuclei with an odd proton vs. odd neutron could allow one to distinguish operators involving u quarks from those involving d quarks; this is interesting because the distinction is difficult to make for SI operators. (orig.)

  6. Comments on &apos;&apos;Analysis of spherical imploding shocks&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Lazarus, R.B.

    1980-04-01

    It is asserted that Fujimoto and Mishkin&apos;s article is incorrect in its claim for a pressure extremum at or behind the shock for all values of ..gamma.. and in its claim for an analytical form for the similarity exponent. (AIP)

  7. OBJECTIVE BAYESIAN ANALYSIS OF &apos;'ON/OFF'&apos; MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, Diego, E-mail: diego.casadei@fhnw.ch [Visiting Scientist, Department of Physics and Astronomy, UCL, Gower Street, London WC1E 6BT (United Kingdom)

    2015-01-01

    In high-energy astrophysics, it is common practice to account for the background overlaid with counts from the source of interest with the help of auxiliary measurements carried out by pointing off-source. In this &apos;'on/off'&apos; measurement, one knows the number of photons detected while pointing toward the source, the number of photons collected while pointing away from the source, and how to estimate the background counts in the source region from the flux observed in the auxiliary measurements. For very faint sources, the number of photons detected is so low that the approximations that hold asymptotically are not valid. On the other hand, an analytical solution exists for the Bayesian statistical inference, which is valid at low and high counts. Here we illustrate the objective Bayesian solution based on the reference posterior and compare the result with the approach very recently proposed by Knoetig, and discuss its most delicate points. In addition, we propose to compute the significance of the excess with respect to the background-only expectation with a method that is able to account for any uncertainty on the background and is valid for any photon count. This method is compared to the widely used significance formula by Li and Ma, which is based on asymptotic properties.

  8. &apos;'Spin-dependent'&apos; μ → e conversion on light nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, Sacha; Saporta, Albert [IPNL, CNRS/IN2P3, Villeurbanne (France); Universite Claude Bernard Lyon 1, Villeurbanne (France); Universite de Lyon, Lyon (France); Kuno, Yoshitaka [Osaka University, Department of Physics, Toyonaka, Osaka (Japan)

    2018-02-15

    The experimental sensitivity to μ → e conversion will improve by four or more orders of magnitude in coming years, making it interesting to consider the &apos;'spin-dependent'&apos; (SD) contribution to the rate. This process does not benefit from the atomic-number-squared enhancement of the spin-independent (SI) contribution, but probes different operators. We give details of our recent estimate of the spin-dependent rate, expressed as a function of operator coefficients at the experimental scale. Then we explore the prospects for distinguishing coefficients or models by using different targets, both in an EFT perspective, where a geometric representation of different targets as vectors in coefficient space is introduced, and also in three leptoquark models. It is found that comparing the rate on isotopes with and without spin could allow one to detect spin-dependent coefficients that are at least a factor of few larger than the spin-independent ones. Distinguishing among the axial, tensor and pseudoscalar operators that induce the SD rate would require calculating the nuclear matrix elements for the second two. Comparing the SD rate on nuclei with an odd proton vs. odd neutron could allow one to distinguish operators involving u quarks from those involving d quarks; this is interesting because the distinction is difficult to make for SI operators. (orig.)

  9. Thermal management of a &apos;'BC'&apos; size molicel

    Energy Technology Data Exchange (ETDEWEB)

    Fouchard, D.; Ruggier, L.; Taylor, B.J.

    1987-05-01

    The &apos;'BC'&apos; size MOLICEL using the rechargeable system Li/MoS/sub 2/ has already been shown to have performance characteristics appropriate for use in an electric vehicle battery. The cell design, based on the results of thermal modelling studies, has been modified to provide for improved removal of waste heat resulting from planned high power discharge or from accidental electrical abuse. Experimental verification of the various interfacial thermal impedances was done and an appropriate heat sink specified to use air cooling for the final rejection stage. Fully instrumented 45 Ah test cells were built using a design in which waste heat was caused to flow axially in the aluminum foils forming the cathode current collector. The bottom ends of these foils were thermally integrated to the cell can bottom which had air cooling fins attached externally. Two fully charged cells of this special design were subjected to sustained short circuit whilst being cooled on their fins only with air at 25 km/h. Neither cell experienced any excessive heat built-up and no safety hazard occurred. The results show that thermal management of this type of battery can readily be done using a simple cell design modification and requiring minimum complexity for heat disposal to the environment. The system does not impose any extraordinary constraints on electric vehicle design and it would also be feasible to duct warm air from the battery heat exchanger to provide passenger compartment heating. 17 figs., 7 tabs.

  10. Accidents, &apos;black swans&apos; and risks

    Energy Technology Data Exchange (ETDEWEB)

    Luxat, J.C. [McMaster Univ., Dept. of Engineering Physics, Hamilton, Ontario (Canada)

    2013-06-15

    Major accidents and natural disasters with severe consequences have occurred in all sectors of industrial activity with relatively high frequency. The severe consequences of concern involve either significant loss of life or major economic loss, or both loss of life and economic loss. Such events have the last two years been referred to as &apos;black swan&apos; events following publication of Taleb&apos;s bestselling book. These events demonstrate limits to PRA application that arise from the underlying high uncertainty associated with the estimation of frequency of occurrence of such events. An approach is proposed in this paper that, consistent with the concept of defense in depth employed by the nuclear industry, augments probabilistic risk assessment with a methodology based upon &apos;threat - risk assessment&apos;. This approach shifts these very low frequency high consequence &apos;black swan&apos; events out of the probabilistic risk assessment domain into a deterministic emergency response assessment domain. (author)

  11. Facility Management journal special feature on energy. Intelligent energy supply and air conditioning concept for the &apos;&apos;Bonner Bogen&apos;&apos; buildings; Facility Management-Special &apos;'Energie'&apos;. Intelligentes Energie- und Klimakonzept fuer den &apos;&apos;Bonner Bogen&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2009-11-15

    In the &apos;&apos;Bonner Bogen&apos;&apos; construction project, the focus was on resources-saving technology and maximum user comfort, resulting in an integrated planning and implementation process. According to the investor, BonnVisio, the technical infrastructure and energy center of the building - based on groundwater geothermal energy with aquifer storage - is unique in Germany and Europe in terms of size, mode of operation, and efficiency. (orig.)

  12. Day 2 closing lecture: Anthropocene&apos;s archive?

    International Nuclear Information System (INIS)

    Van Wyck, Peter

    2015-01-01

    Prof. Peter van Wyck&apos;s lecture drew from Crutzen and Stoermer&apos;s concept of the Anthropocene and argued for its theoretical, practical, and rhetorical value with regard to the broad set of concerns that brought participants to Verdun. As an ontological claim, the Anthropocene offers a conceptual challenge to any meaningful distinction between &apos;human&apos; and &apos;natural&apos; history: the human and natural are globally merged like never before (referring to issues such as global warming, biodiversity, space debris, etc.). The Anthropocene is a new fundamental concept and a philosophical event. It marks, for instance, the time when we ask for consideration of time scales beyond anthropometric dimensions. Within the geological, social, and human sciences, one of the questions of the Anthropocene circles around when it would have started. There are various competing ideas about this. Some date it back to the acquisition of fire, others to the Industrial Revolution, and others to the great acceleration of science and technology in the mid-20. century. Nuclear energy has also been suggested as a signature. Overall, Prof. van Wyck suggested that the Anthropocene, as a kind of cultural memo, offers a moment in which cultural awareness around questions relating to nuclear energy may be broadened and enhanced

  13. The &apos;&apos;rising bubble&apos;&apos; sign: a new aid in the diagnosis of unicameral bone cysts

    Energy Technology Data Exchange (ETDEWEB)

    Jordanov, Martin I. [Vanderbilt University Medical Center, Department of Radiology and Radiological Sciences, Nashville, TN (United States)

    2009-06-15

    The observation of a bubble of gas at the most non-dependent margin of a lytic bone lesion which has sustained a pathologic fracture implies that the lesion is hollow and can assist the radiologist in making the diagnosis of a unicameral bone cyst. The imaging studies of two patients who sustained pathologic fractures through unicameral bone cysts and exhibited the &apos;&apos;rising bubble&apos;&apos; sign are shown. The sign&apos;s basis, proper utilization, and potential pitfalls are discussed. (orig.)

  14. Study and designing of the &apos;'caliprax'&apos; measurement bench; Etude et realisation du banc &apos;'caliprax'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Barriere, J.Ch

    2001-09-01

    Probing the matter in order to check its elementary constituents, that is the goal of the particle physic. In this field, the experiments consist in colliding highly energetic particle beams and observing the new born particles. These observations are based on big particle detectors whose running is dependant on the precise knowledge of their geometry (position of the detection chambers). To achieve this, the detectors are equipped with alignment sensors, which have to be calibrated before. This document describes the study and the making of a calibration bench for the &apos;Praxial&apos; (PRoximity AXIAL) type sensors, and other works related to these sensors. In a first part, we determine and apply a method to set the tools used to fix the sensor stands on the detection chambers. These settings are made with the use of a tridimensional measuring machine. Then, we study the stands themselves. These investigations concern mechanics: positioning quality of the sensors in their stands, bending of the supports due to the tightening. In this part too, the studies are in the field of dimensional metrology. After this, the works are reoriented toward the bench, with the choice of the displacement sensors among two different technologies: optical, with the Rasnik system, and mechanical, with linear probes as LVDT (Linear Variable Differential Transformer). Following the discovery of an ambiguity on the Rasnik system, we go on the tests to understand its behaviour. We introduce the theory of the alignment sensors calibration, which is based on a minimization calculation. The computer programs are explained in a chapter, and in an other, the implementation of the quality assurance procedures. An other part describes the mechanical studies and the problems they cause. Because of a delay onset of the project, we make a model of the bench. This dummy allows us to test every single function of the final bench. With this device, we record manually the first calibration data and

  15. The positive impact of &apos;Luz do Campo&apos; program in a rural area: the sericulture in Ribeirao Claro, Parana, Brazil; O impacto positivo do programa &apos;Luz do campo&apos; na extensao rural: a sericicultura em Ribeirao Claro, Parana, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Carmo, Jose R. do; Marques, Rui Manuel B.S.; Betiol Junior, Genesio [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-Graduacao e Energia], e-mail: jrcarmo@iee.usp.br, e-mail: rmanuel@iee.usp.br, e-mail: genesio.betiol@poli.usp.br; Ribeiro, Fernando Selles [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica de Engenharia], e-mail: fribeiro@pea.usp.br

    2004-07-01

    The &apos;Luz do Campo&apos; program has created positive and favorable impact to the opening of opportunities in the rural area. It has contributed to facilitate the access of workers to energetic facilities and has contributed to providing them with better social and economical conditions. As a consequence after the accomplishment of the rural electrification process in the settlements of &apos;Anhumas&apos; and &apos;Maria Neto&apos; implanted in Ribeirao Claro in Parana, it was possible to come to terms with two projects of Sericiculture in that location. The energy consumption of these projects has not been only restricted to human comfort, but has also been aimed at the production. As a result, the economical success achieved in those settlements in less than a year&apos;s time, is due to the transformation actions in the countryside that have lowered poverty and raised the perspectives of better life quality to the settlers. (author)

  16. Radiological investigations at the &apos;Taiga&apos; nuclear explosion site: Site description and in situ measurements

    Energy Technology Data Exchange (ETDEWEB)

    Ramzaev, V., E-mail: V.Ramzaev@mail.ru [Institute of Radiation Hygiene, Mira str. 8, 197101 St.-Petersburg (Russian Federation); Repin, V.; Medvedev, A.; Khramtsov, E.; Timofeeva, M.; Yakovlev, V. [Institute of Radiation Hygiene, Mira str. 8, 197101 St.-Petersburg (Russian Federation)

    2011-07-15

    In the summer of 2009, we performed a field survey of the &apos;Taiga&apos; peaceful underground nuclear explosion site, the Perm region, Russia (61.30{sup o} N, 56.60{sup o} E). The explosion was carried out by the USSR in 1971. This paper provides an extended summary of the available published data on the &apos;Taiga&apos; experiment. A detailed description of the site is illustrated by original aerial and ground-level photos. A large artificial lake (700 m long and 350 m wide) currently occupies the central area of the experimental site. The ground lip surrounding the lake is covered by a newly grown mixed forest. In situ measurements, performed in August 2009, revealed elevated levels of the {gamma}-ray dose rate in air on the banks of the lake &apos;Taiga&apos;. Two hot spots were detected on the eastern bank of the lake. The excess of the {gamma}-ray radiation is attributable to the man-made radionuclides {sup 60}Co and {sup 137}Cs. The current external {gamma}-ray dose rate to a human from the contaminations associated with the &apos;Taiga&apos; experiment was between 9 and 70 {mu}Sv per week. Periodic monitoring the site is recommended. - Highlights: > We studied a radiation anomaly at the &apos;Taiga&apos; underground nuclear explosion site. > The anomaly currently has an area of approximately 1 km{sup 2}. > The excess of {gamma}-ray radiation at the site is mainly attributable to {sup 60}Co and {sup 137}Cs. > The external effective dose may currently exceed the negligible value of 10 {mu}Sv y{sup -1}.

  17. Physico-chemical characterization of human recombinant follicle-stimulating hormone (hFSH) and its subunits by reversed-phase high-performance liquid chromatography ( RP-HPLC): comparison with pituitary hFSH reference preparation from &apos;National Hormone and Pituitary Program&apos; from USA; Caracterizacao fisico-quimica da foliculotropina humana(hFSH) recombinabte e de suas subunidades, por cromatografia liquida de alta eficiencia (HPLC) em fase reversa: comparacao com a preparacao de referencia de hFSH de origem hipofisaria do &apos;&apos;National Hormone and Pituitary Program&apos;&apos; dos EUA

    Energy Technology Data Exchange (ETDEWEB)

    Loureiro, Renan Fernandes

    2006-07-01

    A reversed-phase high-performance liquid chromatography (RP-HPLC) method for the qualitative and quantitative analysis of intact human folliclestimulating hormone (hFSH) was established and validated for accuracy, precision and sensitivity. Human FSH is a dimeric glycoprotein hormone widely used as a diagnostic analyte and as therapeutic product in reproductive medicine. The technique developed preserves the protein integrity, allowing the analysis of the intact heterodimeric form rather than just of its subunits, as it is the case for the majority of the conditions currently employed. This methodology has also been employed for comparing the relative hydrophobicity of pituitary, urinary and two Chinese hamster ovary (CHO)-derived hFSH preparations, as well as of two other related glycoprotein hormones of the anterior pituitary: human thyroid-stimulating hormone (hTSH) and human luteinizing hormone (hLH). The least hydrophobic of the three glycohormones analyzed was hFSH, followed by hTSH and hLH. A significant difference (p<0.005) was observed in t{sub R} between the pituitary and recombinant hFSH preparations, reflecting structural differences in their carbohydrate moieties. Two main isoforms were detected in urinary hFSH, including a form which was significantly different (p<0.005) for the pituitary and recombinant preparations. The linearity of the dose-response curve (r = 0.9965, n = 15) for this RP-HPLC methodology, as well as an inter-assay precision with relative standard deviation less than 4% for the quantification of different hFSH preparations and a sensitivity of the order of 40 ng, were demonstrated. The chromatographic behavior and relative hydrophobicity of the individual subunits of the pituitary and recombinant preparations were also analyzed. Furthermore, the accurate molecular mass of the individual hFSH subunits and of the heterodimer were simultaneously determined by matrix-assisted laser desorption ionization time-of-flight mass spectral

  18. Regulation of heating and air-conditioning systems based on human thermal sensation: impact on the energy consumption in buildings; Regulation des systemes de chauffage et de climatisation basee sur la sensation thermique humaine: impact sur la consommation d&apos;energie dans les batiments

    Energy Technology Data Exchange (ETDEWEB)

    Endravadan, M.

    2006-02-15

    This study is based on the adaptive approach. The thermal comfort of an individual depends on indoor conditions that can be controlled. However, changes in activity or clothing adjustments are difficult to control and measure in the field experiments. Behavioural actions undertaken by the occupant to overcome the discomfort could be varying and may have diverse consequences. Sometimes these actions are beneficial to the occupant, although often they lead to disastrous amounts of energy consumption. Hence, it becomes crucial to consider the human behaviour and the thermal inertia of the building. The creation of numerical models is useful to study the coupling between these two components and to evaluate the effects of the behaviour on comfort and the energy. The simulations were conducted using TRNSYS software. A model such as &apos;Global Behavioural Regulator&apos; (GBR) was created to evaluate the effects of clothing or thermostat adjustments made by the occupant depending on his thermal sensation (PMV). The energy costs of several types of regulators have been compared in various seasons for example, winter and summer using a light and heavy weight building. The heating of a whole-building may not be necessary in temperate climates or during mid-season. However, comfortable working conditions could be assured for the occupants with the use of an individual heating system such as a &apos;Local Heating System&apos; (LHS). In such a context, it becomes interesting to evaluate the occupant&apos;s behaviour in regards to local heating and its effects on comfort and energy consumption. The LHS consists of three radiant panels; therefore, it is important to evaluate the local heat exchanges with precision. Experiments conducted with the manikin were used to validate the infra-red model; whereas experiments with real subjects were studied to understand the occupant behaviour on the LHS as a function of their local thermal sensations. These analyses led to the creation

  19. Annotated bibliography for liquid metal surface tensions of groups III-A, IV-A, and V-A metals

    International Nuclear Information System (INIS)

    Murtha, M.J.; Burnet, G.

    1976-04-01

    An annotated bibliography has been prepared which includes summaries of 82 publications dating from 1920 and dealing with the measurement of the surface tensions of Groups III-A, IV-A, and V-A metals in the liquid state. The bibliography is organized by key element investigated, and contains a tabulation of correlations for surface tension as a function of temperature. A brief discussion dealing with variables and methods has been included

  20. &apos;'Routine'&apos; brain CT in psychiatric patients - does it make sense?; &apos;'Routine'&apos;-Schaedel-CT in der psychiatrischen Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Pickuth, D.; Heywang-Koebrunner, S.H.; Spielmann, R.P. [Martin-Luther-Universitaet Halle-Wittenberg, Halle (Germany). Klinik und Poliklinik fuer Diagnostische Radiologie

    1999-11-01

    Purpose: To prospectively assess the spectrum of brain CT findings in psychiatric patients and to determine the number of patients that had an underlying cause for the symptoms. Patients and methods: Over a period of six months, 142 patients (78 males, 64 females; median age 61 [18-91] years) were referred for CT brain scans. Their scans were reviewed, along with the clinical information that was provided in the request form. All the hard copies were reviewed to assess areas of ischaemia, infarction, atrophy, tumours, and haematomas. The majority of requests were to exclude vascular event or space-occupying lesions. Clinical indications included mood disorders (depression, mania), schizophrenic disorders, dementia, personality and behavioural disorders. Results: 31 (22%) were normal. 111 (78%) had varying degrees of ischaemia, infarction and cerebral/cerebellar atrophy. 7 (4.9%) had space-occupying lesions which included two gliomas and five meningiomas. There were two chronic subdural haematomas and one arteriovenous malformation. Conclusion: 1. In our series, pathologic findings in &apos;routine&apos; brain CT&apos;s were encountered in 78%. 2. The incidence of brain tumours was 4.9%, compared with 0.00005% of the general population. 3. CT scanning in psychiatric patients is cost-effective and especially indicated when there is an atypical presentation, or inadequate response to standard treatment. (orig.) [German] Hintergrund: Bei psychiatrischen Patienten wird vielerorts routinemaessig eine kraniale Computertomographie (CCT) durchgefuehrt. Ob der Nutzen die Kosten rechtfertigt, wurde im Rahmen einer Prospektivstudie untersucht. Patienten und Methode: In einem Zeitraum von 6 Monaten wurde bei 142 psychiatrischen Patienten (78 Maenner, 64 Frauen, 18-91 Jahre, Median 61 Jahre) ein CCT angefertigt. Die Untersuchung erfolgt nativ in 5-mm-Schichtdicke, bei klinischem Verdacht auf eine intrakraniale Raumforderung auch kontrastverstaerkt. Ueberweisungsdiagnosen waren v

  1. The adductor magnus &apos;'mini-hamstring'&apos;: MRI appearance and potential pitfalls

    International Nuclear Information System (INIS)

    Broski, Stephen M.; Murthy, Naveen S.; Collins, Mark S.; Krych, Aaron J.; Obey, Mitchel R.

    2016-01-01

    To examine the anatomic MRI characteristics of the adductor magnus mini hamstring (AMMH) and explore its involvement in cases of hamstring avulsion. An IRB-approved retrospective review of patients undergoing &apos;&apos;hamstring protocol&apos;&apos; MRI between March 2009 and June 2014 was performed. Two musculoskeletal radiologists recorded multiple AMMH anatomic characteristics and involvement in cases of hamstring avulsion. Seventy-six AMMHs were analyzed in 66 patients [35 females and 31 males, mean age 49.3 ± 15.2 years (range 17-81)]. Eleven percent of AMMHs were poorly visualized, 51 % visualized, and 37 % well visualized. Seven percent demonstrated round, 73 % ovoid, and 21 % flat/lenticular tendon morphologies. Most (88 %) demonstrated typical origins. Average cross-sectional area (CSA) was 22.4 ± 10.6 mm 2 (range 6-56), diameter was 7.2 ± 2.5 mm (range 2.9-15), medial distance from the semimembranosus tendon was 7.5 ± 2.5 mm (range 3-14), and tendon length was 6.8 ± 3.3 cm (range 1.2-14.1). There was no gender difference in AMMH anatomic measurements or correlation between age and CSA or diameter. Of 17 complete hamstring avulsion cases, the AMMH was intact in 13, partially torn in 3, and completely torn in 1. The AMMH is a constant finding with variable anatomic characteristics. It is visualized or well visualized by MRI in 88 % of cases and is a sizable tendon located in close proximity to the semimembranosus tendon. Because it is uncommonly completely torn (6 %) in cases of complete hamstring avulsion, radiologists should be aware of its presence and appearance to avoid diagnostic confusion. (orig.)

  2. The adductor magnus &apos;'mini-hamstring'&apos;: MRI appearance and potential pitfalls

    Energy Technology Data Exchange (ETDEWEB)

    Broski, Stephen M.; Murthy, Naveen S.; Collins, Mark S. [Department of Radiology, Mayo Clinic, Rochester, MN (United States); Krych, Aaron J. [Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN (United States); Obey, Mitchel R. [Mayo School of Graduate Medical Education, Rochester, MN (United States)

    2016-02-15

    To examine the anatomic MRI characteristics of the adductor magnus mini hamstring (AMMH) and explore its involvement in cases of hamstring avulsion. An IRB-approved retrospective review of patients undergoing &apos;&apos;hamstring protocol&apos;&apos; MRI between March 2009 and June 2014 was performed. Two musculoskeletal radiologists recorded multiple AMMH anatomic characteristics and involvement in cases of hamstring avulsion. Seventy-six AMMHs were analyzed in 66 patients [35 females and 31 males, mean age 49.3 ± 15.2 years (range 17-81)]. Eleven percent of AMMHs were poorly visualized, 51 % visualized, and 37 % well visualized. Seven percent demonstrated round, 73 % ovoid, and 21 % flat/lenticular tendon morphologies. Most (88 %) demonstrated typical origins. Average cross-sectional area (CSA) was 22.4 ± 10.6 mm{sup 2} (range 6-56), diameter was 7.2 ± 2.5 mm (range 2.9-15), medial distance from the semimembranosus tendon was 7.5 ± 2.5 mm (range 3-14), and tendon length was 6.8 ± 3.3 cm (range 1.2-14.1). There was no gender difference in AMMH anatomic measurements or correlation between age and CSA or diameter. Of 17 complete hamstring avulsion cases, the AMMH was intact in 13, partially torn in 3, and completely torn in 1. The AMMH is a constant finding with variable anatomic characteristics. It is visualized or well visualized by MRI in 88 % of cases and is a sizable tendon located in close proximity to the semimembranosus tendon. Because it is uncommonly completely torn (6 %) in cases of complete hamstring avulsion, radiologists should be aware of its presence and appearance to avoid diagnostic confusion. (orig.)

  3. The trochlear cleft: the &apos;&apos;black line&apos;&apos; of the trochlear trough

    Energy Technology Data Exchange (ETDEWEB)

    Wissman, Robert D.; Nepute, Joshua; Fischer, Nathaniel von; Radhakrishnan, Rupa; Hendry, Daniel [University of Cincinnati Medical Center, Department of Radiology, Cincinnati, OH (United States); Ingalls, Jerrell [Desert Radiologists, Las Vegas, NV (United States); Kenter, Keith [University of Cincinnati Medical Center, Department of Orthopaedic Surgery, Cincinnati, OH (United States)

    2012-09-15

    The &apos;&apos;cartilage black line sign&apos;&apos; is a recently described T2 dark cartilage lesion that we have identified appearing as a cleft in the trochlear trough. The purpose of our study was to define the MR imaging characteristics of a trochlear cleft, determine its incidence, and correlate the MR findings with arthroscopy. A total of 1,300 consecutive MR examinations of the knee were retrospectively reviewed by consensus of two fellowship-trained musculoskeletal radiologists. The MR imaging characteristics and location of a trochlear cleft were determined. Imaging results were compared to arthroscopy when available. Patient age and gender were compared to 25 randomly selected control patients without trochlear clefts. A total of 25 (1.9%) individuals (11 females and 14 males; age range 19-45 years; mean age 28 years) were diagnosed with a trochlear cleft. The control group consisted of 11 females and 14 males; age range 19-83 years; mean age 46 years. Mean cleft length was 7 mm (range 6-12 mm); cleft location was consistently in the lower trochlear trough. No full-thickness cartilage defects were identified in the eight individuals in whom arthroscopic correlation was available. A grade 2 cartilage lesion was identified in a single individual; another progressed from grade 0 to a full-thickness trochlear lesion over an 8-month interval. Eight individuals were athletes. No significant difference in gender was noted between the two groups, however, the study group was significantly younger p < 0.0001. A trochlear cleft is a rare finding in young active individuals. It most likely indicates an incomplete cartilage fissure which may rarely progress to a full-thickness defect. (orig.)

  4. &apos;&apos;Atomic Optics&apos;&apos;: Nonimaging Optics on the Nanoscale

    Energy Technology Data Exchange (ETDEWEB)

    Roland Winston Joseph O' Gallagher

    2005-01-15

    This is the final report for a one year close out extension of our basic research program that was established at the University of Chicago more than sixteen years ago to explore and develop the optical sub-discipline that has come to be known as &apos;&apos;nonimaging optics&apos;&apos;. This program has been extremely fruitful, having both broadened the range of formalism available for workers in this field and led to the discovery of many new families of optical devices. These devices and techniques have applications wherever the efficient transport and transformation of light distributions are important, in particular in illumination, fiber optics, collection and concentration of sunlight, and the detection of faint light signals in physics and astrophysics. Over the past thirty years, Nonimaging Optics (Welford and Winston, 1989) has brought a fresh approach to the analysis of many problems in classical macro-scale optics. Through the application of phase-space concepts, statistical methods, thermodynamic arguments, etc., many previously established performance limits were able to be broken and many technical surprises with exciting practical applications were discovered. The most recent three-year phase of our long-term continuing program ended in late 2002 and emphasized extending our work in geometrical optics and expanding it to include some interesting questions in physical optics as well as in the new field of statistical optics. This report presents a survey of the basic history and concepts of nonimaging optics and reviews highlights and significant accomplishments over the past fifteen years. This is followed by a more detailed summary of recent research directions and accomplishments during the last three years. This most recent phase was marked by the broadening in scope to include a separate project involving a collaboration with an industrial partner, Science Applications International Corporation (SAIC). This effort was proposed and approved in

  5. NDA National Graduate Programme &apos;nucleargraduates&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Dawson, Carl

    2010-07-01

    The aim of this paper is to outline the NDA National Graduate Programme (nuclear graduates). The NDA has a remit under the Energy Act (2004) &apos;to maintain and develop the skills for decommissioning and nuclear clean-up&apos;. Although current research is now being reviewed, there is significant evidence to suggest that the age profile in the Site Licence Companies is skewed towards older workers and there is likely to be a skill shortage in 3-5 years. As nuclear clean-up is a national issue; skill shortages also become a national issue in a very real sense. In addition, evidence suggests that the industry needs to be constantly challenged in order to achieve its targets for decommissioning. The NDA has a unique position under the Act. It is both a strategic overseer and direct employer. To this end the &apos;National Graduate Programme&apos; is aligned to both the NDA&apos;s previous succession plans and the needs of the industry. Industry needs leadership that challenges the status quo and moves the UK nuclear industry to become best in class; Industry needs a dedicated to programme to address skills shortages and difficult to recruit areas such as, but not exclusively, estimators, schedulers, contract managers, site engineers, decommissioning technicians, safety monitors; The NDA has indicated a &apos;commercial and politically savvy&apos; cohort is required to meet its own internal challenges and to ensure sustainability in its own workforce, and to be sensitive to the needs of customers and suppliers alike; Need to create a more diversified workforce in the nuclear industry and also plan for new skills evolving from research and development breakthroughs; Need to ensure that Tier 1, 2, 3 and 4 contractors invest in the leadership and skills for the future. World Class - delivery will be benchmarked against UK based multinational companies who operate in a global graduate attraction and development marketplace. The graduates targeted will be from leading

  6. Outcomes in diabetic foot ulcer patients with isolated T2 marrow signal abnormality in the underlying bone: should the diagnosis of &apos;'osteitis'&apos; be changed to &apos;&apos;early osteomyelitis&apos;&apos;?

    Energy Technology Data Exchange (ETDEWEB)

    Duryea, Dennis; Bernard, Stephanie; Flemming, Donald; Walker, Eric; French, Cristy [Milton S. Hershey Medical Center, Department of Radiology, H066, 500 University Drive, PO Box 850, Hershey, PA (United States)

    2017-10-15

    To evaluate the variability of clinical treatment and outcomes based on reporting of diabetic foot ulcer MRI findings of adjacent marrow T2 hyperintensity with normal T1 signal. A retrospective review was conducted of 46 MRI examinations evaluating diabetic foot ulcers that demonstrated normal T1 marrow signal, but T2 marrow hyperintensity deep to the ulcer. The cohort was divided based on MRI report impressions into three groups; &apos;&apos;osteitis without osteomyelitis&apos;&apos; (OW), &apos;&apos;osteitis but cannot exclude early osteomyelitis&apos;&apos; (OCEO) and &apos;&apos;early osteomyelitis&apos;&apos; (EO). Patient demographics (age, gender) and accessory MRI findings of ulcer and sinus tract depth were recorded. Initial clinical assessment and medical treatment (route and duration of antibiotics), healing versus disease progression and histology or microbiology results were recorded. The isolated marrow T2 signal hyperintensity was reported as OW in 12 patients, OCEO in 18, and EO in 16. No statistical difference in clinical assessment was demonstrated between the OW, OCEO, and EO groups. Pathological condition was available in 15 patients within 0-7 days (mean 2.4 days) of the MRI examination, with 14 (93%) of these positive for osteomyelitis by histopathology or positive cultures. Initial diagnosis of or progression to osteomyelitis was shown in 28 patients (61%). Treatment of suspected osteomyelitis is heavily determined by clinical factors. Patients who initially demonstrate only T2 marrow signal abnormality under a diabetic ulcer are eventually diagnosed as osteomyelitis in 61% of cases and deserve aggressive treatment as early osteomyelitis when meeting clinical parameters. (orig.)

  7. Report of working committee 3 &apos;&apos;liquefied gases&apos;&apos;; Rapport du comite de travail 3 &apos;&apos;gaz liquefies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Baudino, M.

    2000-07-01

    Working Committee 3&apos;s report concerns the evolution of the liquefied gas industry: both liquefied natural gas (LNG) and liquefied petroleum gases (LPG). Given the current state of the LNG market the Committee decided to concentrate on this area in particular. A number of aspects have been identified which the Committee has been looking at, while others have been given to Study Groups set up specifically for the purpose. The first aspects regard: - the development of LNG and LPG, new installations, future chains and relevant statistical data; - the role of LNG and LPG in starting up a gas industry; - operating and technological improvements in the LNG industry; - energy savings, cold utilization and reduction of CO{sub 2} emissions. The Study Groups which were set up dealt with the following subjects: Technological and Economical Developments for cost Reduction of LNG/LPG Facilities. Small Scale LNG Projects and Modular Systems. LNG/LPG Peak Shaving and Satellite Plants. LNG versus Pipeline Infrastructure. (author)

  8. Quantifying the &apos;naturalness&apos; of the curvaton model

    Energy Technology Data Exchange (ETDEWEB)

    Lerner, Rose N. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Helsinki Institute of Physics (Finland); Melville, Scott [Helsinki Institute of Physics (Finland)

    2014-02-15

    We investigate the probability of obtaining an observable curvature perturbation, using as an example the minimal curvaton-Higgs (MCH) model. We determine &apos;probably observable&apos; and &apos;probably excluded&apos; regions of parameter space assuming generic initial conditions and applying a stochastic approach for the curvaton&apos;s evolution during inflation. Inflation is assumed to last longer than the N{sub obs}≅55 observable e-folds, and the total number of e-folds of inflation determines the particular ranges of parameters that are probable. For the MCH model, these &apos;probably observable&apos; regions always lie within the range 8 x 10{sup 4} GeV≤m{sub σ}≤2 x 10{sup 7} GeV, where m{sub σ} is the curvaton mass, and the Hubble scale at horizon exit is chosen as H{sub *}=10{sup 10} GeV. Because the &apos;probably observable&apos; region depends on the total duration of inflation, information on parameters in the Lagrangian from particle physics and from precision CMB observables can therefore provide information about the total duration of inflation, not just the last N{sub obs} e-folds. This method could also be applied to any model that contains additional scalar fields to determine the probability that these scalar fields contribute to the curvature perturbation.

  9. Thirty years ago: &apos;&apos;InterCity 79&apos;&apos; - every hour, every class; Vor 30 Jahren: IC 79 - jede Stunde - jede Klasse

    Energy Technology Data Exchange (ETDEWEB)

    Jaensch, Eberhard

    2009-05-15

    The &apos;&apos;IC 79&apos;&apos; system, which was introduced thirty years ago, has permanently moulded the shape of long-distance passenger services in Germany (with Deutsche Bundesbahn and later Deutsche Bahn). Since then, top-grade passenger trains have been running regularly every hour on several routes. They provide links with short travel times between the country&apos;s most important towns and cities. &apos;&apos;IC 79&apos;&apos; became the backbone of long-distance rail travel in Germany. The ideas underlying it and the way they were implemented are still considered exemplary today. (orig.)

  10. PET imaging of HER1-expressing xenografts in mice with {sup 86}Y-CHX-A&apos;&apos;-DTPA-cetuximab

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, Tapan K.; Regino, Celeste A.S.; Milenic, Diane E.; Garmestani, Kayhan; Baidoo, Kwamena E.; Brechbiel, Martin W. [National Institutes of Health, Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD (United States); Wong, Karen J. [National Institutes of Health, Molecular Imaging Program, National Cancer Institute, Bethesda, MD (United States); Szajek, Lawrence P. [National Institutes of Health, PET Department, Warren G. Magnuson Clinical Center, Bethesda, MD (United States)

    2010-07-15

    Cetuximab is a recombinant, human/mouse chimeric IgG{sub 1} monoclonal antibody that binds to the epidermal growth factor receptor (EGFR/HER1). Cetuximab is approved for the treatment of patients with HER1-expressing metastatic colorectal cancer. Limitations in currently reported radiolabeled cetuximab for PET applications prompted the development of {sup 86}Y-CHX-A&apos;&apos;-DTPA-cetuximab as an alternative for imaging HER1-expressing cancer. {sup 86}Y-CHX-A&apos;&apos;-DTPA-cetuximab can also serve as a surrogate marker for {sup 90}Y therapy. Bifunctional chelate, CHX-A&apos;&apos;-DTPA was conjugated to cetuximab and radiolabeled with {sup 86}Y. In vitro immunoreactivity was assessed in HER1-expressing A431 cells. In vivo biodistribution, PET imaging and noncompartmental pharmacokinetics were performed in mice bearing HER1-expressing human colorectal (LS-174T and HT29), prostate (PC-3 and DU145), ovarian (SKOV3) and pancreatic (SHAW) tumor xenografts. Receptor blockage was demonstrated by coinjection of either 0.1 or 0.2 mg cetuximab. {sup 86}Y-CHX-A&apos;&apos;-DTPA-cetuximab was routinely prepared with a specific activity of 1.5-2 GBq/mg and in vitro cell-binding in the range 65-75%. Biodistribution and PET imaging studies demonstrated high HER1-specific tumor uptake of the radiotracer and clearance from nonspecific organs. In LS-174T tumor-bearing mice injected with {sup 86}Y-CHX-A&apos;&apos;-DTPA-cetuximab alone, {sup 86}Y-CHX-A&apos;&apos;-DTPA-cetuximab plus 0.1 mg cetuximab or 0.2 mg cetuximab, the tumor uptake values at 3 days were 29.3 {+-} 4.2, 10.4 {+-} 0.5 and 6.4 {+-} 0.3%ID/g, respectively, demonstrating dose-dependent blockage of the target. Tumors were clearly visualized 1 day after injecting 3.8-4.0 MBq {sup 86}Y-CHX-A&apos;&apos;-DTPA-cetuximab. Quantitative PET revealed the highest tumor uptake in LS-174T (29.55 {+-} 2.67%ID/cm{sup 3}) and the lowest tumor uptake in PC-3 (15.92 {+-} 1.55%ID/cm{sup 3}) xenografts at 3 days after injection

  11. Irradiation as a quarantine treatment of &apos;Carabao&apos; (&apos;Manila Super&apos;) mangoes

    International Nuclear Information System (INIS)

    Manoto, E.C.; Resilva, S.S.; Del Rosario, Ma.S.; Casubha, L.C.

    1990-01-01

    Researches using gamma radiation for disinfestation of Oriental fruit fly in &apos;Carabao&apos; (&apos;Manila Super&apos;) mangoes were undertaken using the Probit 9 or 99.9968% mortality test. The results showed that the mature larvae of the fruit fly are the most tolerant stage of this insect to irradiation with the eggs as the most sensitive. On treating more than 100,000 mature larvae in mangoes, a minimum dose of 100 Gy was found to prevent emergence of adult fruit flies and maintain quarantine security or a complete elimination of the possibility of introducing this pest into the importing country. Therefore, the use of 100-Gy irradiation as a quarantine treatment against Oriental fruit fly in the mature green Philippine &apos;carabao&apos; mango fruits is recommended

  12. Narratives as an educational tool : a review of &apos;A Scientific Romance&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, J.; Andrey, J. [Waterloo Univ., ON (Canada). Dept. of Geography

    2000-06-01

    This paper examined how the use of narratives can be used as a tool for educating the public on climate change with particular reference to Ronald Wright&apos;s 1997 novel entitled A Scientific Romance. The novel develops climate change as a central theme in the development plot and has received excellent reviews from literary critics in Canada, Great Britain and the United States. This paper reviewed the novel using criteria from both cognitive psychology and climatology. Cognitive theory claims that human beings think, perceive, understand and make choices according to narrative structures. This evaluation compared Wright&apos;s depiction of future climate change with scientific projections. Wright provides great detail regarding climatic conditions of the Great London-Thames Estuary region of Southern England in the years 2500-2501. The climatic variables used in the evaluation consist of surface temperature, sea level rise, precipitation and wind speed. This evaluation determined that Wright&apos;s narrative depiction of London&apos;s future climate is much more extreme than what scientists project. It was concluded that Wright&apos;s tightly woven narrative takes an abstract issue and successfully transforms it into something interesting and provides a detailed depiction of a plausible future climate and its implications for society. However, two minor weaknesses were found to exist. First, there is little reference to the major cause of climate change, and secondly, the climate scenario depicted in the novel is more consistent with the runaway greenhouse theory than with scientists&apos; projections. It was cautioned that narratives must be used carefully and responsibly otherwise, the magnitude of portrayed changes may create a sense of disbelief or helplessness on the part of the public. 27 refs., 1 tab.

  13. Intranasal delivery of E-selectin reduces atherosclerosis in ApoE-/- mice.

    Directory of Open Access Journals (Sweden)

    Xinhui Li

    Full Text Available Mucosal tolerance to E-selectin prevents stroke and protects against ischemic brain damage in experimental models of stroke studying healthy animals or spontaneously hypertensive stroke-prone rats. A reduction in inflammation and neural damage was associated with immunomodulatory or "tolerogenic" responses to E-selectin. The purpose of the current study on ApoE deficient mice is to assess the capacity of this stroke prevention innovation to influence atherosclerosis, a major underlying cause for ischemic strokes; human E-selectin is being translated as a potential clinical prevention strategy for secondary stroke. Female ApoE-/- mice received intranasal delivery of E-selectin prior to (pre-tolerization or simultaneously with initiation of a high-fat diet. After 7 weeks on the high-fat diet, lipid lesions in the aorta, serum triglycerides, and total cholesterol were assessed as markers of atherosclerosis development. We also assessed E-selectin-specific antibodies and cytokine responses, in addition to inflammatory responses that included macrophage infiltration of the aorta and altered gene expression profiles of aortic mRNA. Intranasal delivery of E-selectin prior to initiation of high-fat chow decreased atherosclerosis, serum total cholesterol, and expression of the leucocyte chemoattractant CCL21 that is typically upregulated in atherosclerotic lesions of ApoE-/- mice. This response was associated with the induction of E-selectin specific cells producing the immunomodulatory cytokine IL-10 and immunosuppressive antibody isotypes. Intranasal administration of E-selectin generates E-selectin specific immune responses that are immunosuppressive in nature and can ameliorate atherosclerosis, a major risk factor for ischemic stroke. These results provide additional preclinical support for the potential of induction of mucosal tolerance to E-selectin to prevent stroke.

  14. Radiobiological study of the radioprotective activity of a natural Iranian compound, &apos;'Shir-Khecht'&apos;; Etude radiobiologique de l&apos;activite radioprotectrice d&apos;un compose naturel Iranien: le &apos;'Shir-Khecht'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rouhanizadeh, N. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-01-01

    After reviewing the primary mechanisms of the action of ionizing radiation, the possible mechanisms of the action of radioprotective substances, the various chemical structures having a protective effect and the methods for studying chemical radioprotection, the author presents the results he has obtained with natural Iranian product: &apos;'Shir-Khecht'&apos;. Tests with this product at lethal and sublethal doses have been carried out on the rat using various means of introduction. The effect of radiation, both with and without protection, has been studied using histological and biochemical methods. The product examined has, in effect, a protective action; it is, furthermore, non-toxic and active when taken orally. (author) [French] Apres avoir rappele les mecanismes primaires de l&apos;action des rayonnements ionisants, les mecanismes possibles de l&apos;action des substances radioprotectrices, les diverses structures chimiques possedant un effet protecteur et les methodes d&apos;etude de la radioprotection chimique, l&apos;auteur presente les resultats qu&apos;il a obtenus en utilisant un compose naturel iranien: le &apos;'Shir-Khecht'&apos;. Des essais de ce produit, chez le rat, par diverses voies d&apos;introduction, a dose letale et subletale ont ete effectues. L&apos;effet des radiations, avec et sans protection, a ete etudie a l&apos;aide de methodes histologiques et biochimiques. Le compose essaye possede un pouvoir protecteur; il est, de plus, non toxique et actif par voie orale. (auteur)

  15. Maintain levels of nicotine but reduce other smoke constituents: a formula for &apos;'less-hazardous'&apos; cigarettes

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, J.C.; Young, J.C.; Rickert, W.S.

    1984-09-01

    Twenty-two volunteers who smoked more than 20 cigarettes with &apos;'high'&apos; nicotine yields (0.8 to 1.2 mg) per day participated in an 8-week study designed to test the hypothesis that smoking cigarettes with a constant level of nicotine but reduced deliveries of tar, carbon monoxide, and hydrogen cyanide leads to a decrease in smoke absorption. All subjects smoked their usual high-nicotine brand for the first 3 weeks (P1), and the absorption of smoke constituents was determined from levels of thiocyanate and cotinine in saliva and serum, levels of carbon monoxide in expired air, and levels of carboxyhemoglobin in the blood. During the final 5 weeks (P2), the treatment group (16 subjects) switched to the &apos;'light'&apos; version of their usual brands (similar yields of nicotine but with reduced yields of tar, carbon monoxide, and hydrogen cyanide); the control group (6 subjects) smoked their usual brands for the duration of the study. Average levels of cotinine for the subjects who switched during P2 were not significantly different from those of the control group as was expected. Slight reductions were noted in average expired-air carbon monoxide levels, blood carboxyhemoglobin, and saliva thiocyanate, but these reductions were smaller than anticipated based on brand characteristics. The results suggest that the ratio of smoke constituents is different when individuals, rather than machines, smoke cigarettes. Yields determined under subject-defined conditions are necessary in order to properly evaluate the role of nicotine in the design of &apos;'less-hazardous'&apos; cigarettes.

  16. A goodness of fit and validity study of the Korean radiological technologists&apos; core job competency model

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Chang Seon [Dept. of Radiological Science, Konyang University College of Medical Sciences, Daejeon (Korea, Republic of); Cho, A Ra [Dept. of Medical Education, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of); Hur, Yera [Dept. of Medical Education, Konyang University College of Medicine, Daejeon (Korea, Republic of); Choi, Seong Youl [Dept. of Occupational Therapy, Kwangju women’s University, Gwangju (Korea, Republic of)

    2017-09-15

    Radiological Technologists deals with the life of a person which means professional competency is essential for the job. Nevertheless, there have been no studies in Korea that identified the job competence of radiologists. In order to define the core job competencies of Korean radiologists and to present the factor models, 147 questionnaires on job competency of radiology were analyzed using &apos;PASW Statistics Version 18.0&apos; and &apos;AMOS Version 18.0&apos;. The valid model consisted of five core job competencies (&apos;Patient management&apos;, &apos;Health and safety&apos;, &apos;Operation of equipment&apos;, &apos;Procedures and management&apos;) and 17 sub – competencies. As a result of the factor analysis, the RMSEA value was 0.1 and the CFI, and TLI values were close to 0.9 in the measurement model of the five core job competencies. The validity analysis showed that the mean variance extraction was 0.5 or more and the conceptual reliability value was 0.7 or more , And there was a high correlation between subordinate competencies included in each subordinate competencies. The results of this study are expected to provide specific information necessary for the training and management of human resources centered on competence by clearly showing the job competence required for radiologists in Korea&apos;s health environment.

  17. Electrolyzed-water generator &apos;SaniBoy&apos;; Eisei jokinsuik kyokyu sochi &apos;SaniBoy&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, M.; Kakiuchi, H.; Muto, K. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-03-10

    In the food industry, injuries due to food poisoning have been increasing. Especially the mass outbreak of food poisoning by Escherichia coli such as O-157 in 1996 gave warning on the importance of food sanitation management. Public efforts such as the Hazard Analysis and Critical Control Point (HACCP) system have been made to prevent food poisoning. Recently, disinfection made by electrolyzing water with some salt added has attracted attention. Fuji Electric has developed the generator &apos;SaniBoy&apos; that produces weak alkaline electrolyzed water without wasting water. The environment-friendly &apos;SaniBoy&apos; will contribute to sanitation in various fields. (author)

  18. The &apos;diester partners&apos; want to be movers...; Les &apos;&apos;partenaires diester&apos;&apos; se veulent moteur...

    Energy Technology Data Exchange (ETDEWEB)

    Tourneur, J.C.

    2003-09-01

    Diester is the French name given to the biofuel (methylic ester) made from vegetal oils (1 t of vegetal oil + 0.1 t of methanol leads to 1 t of diester + 0.1 t of glycerin). The French club of &apos;diester towns&apos; gathers all local authorities of towns that use up to 30% of diester in the diesel fuel of their vehicle fleets (buses, trucks, commercial vehicles). In March 2003, the association has opened to new members, in particular private companies which are diester users and become &apos;diester partners&apos;, in order to sustain the fight against the greenhouse effect. The consumption of 1 t of diester allows to save 2.5 t of CO{sub 2} thanks to the photosynthesis. In other words, a vehicle fueled with 30% of diester and 70% of diesel fuel reduces its greenhouse gas emissions of 23%. (J.S.)

  19. Stressors at modern workplaces. &apos;'Technical-stres'&apos;-investigations in power plants; Stressoren an modernen Arbeitsplaetzen. Untersuchungen zum &apos;Technikstress&apos; in Kraftwerken

    Energy Technology Data Exchange (ETDEWEB)

    Hoppe, Annette; Binkowski, Sven [Brandenburgische Technische Univ. Cottbus (DE). Lehrgebiet Arbeitswissenschaft/Arbeitspsycholgoie (AWIP); Haake, Dietmar [Vattenfall Europe Generation AG und Co. KG, Cottbus (Germany). Elektro- und Leittechnik

    2008-07-01

    The status analyses of power plant control rooms from the viewpoint of ergonomics and psychology is focussing on scientific analyses of stressors at highly complicated work places in order to gain further knowledge on the issue of &apos;technology-induced stress&apos; and to a practical assessment of work places for the estimation of stresses. A guideline is to be developed supporting design of modern control rooms. (orig.)

  20. EAGLE: &apos;EAGLE&apos;Is an&apos; Algorithmic Graph Library for Exploration

    Energy Technology Data Exchange (ETDEWEB)

    2015-01-16

    The Resource Description Framework (RDF) and SPARQL Protocol and RDF Query Language (SPARQL) were introduced about a decade ago to enable flexible schema-free data interchange on the Semantic Web. Today data scientists use the framework as a scalable graph representation for integrating, querying, exploring and analyzing data sets hosted at different sources. With increasing adoption, the need for graph mining capabilities for the Semantic Web has emerged. Today there is no tools to conduct "graph mining" on RDF standard data sets. We address that need through implementation of popular iterative Graph Mining algorithms (Triangle count, Connected component analysis, degree distribution, diversity degree, PageRank, etc.). We implement these algorithms as SPARQL queries, wrapped within Python scripts and call our software tool as EAGLE. In RDF style, EAGLE stands for "EAGLE &apos;Is an&apos; algorithmic graph library for exploration. EAGLE is like &apos;MATLAB&apos; for &apos;Linked Data.&apos;

  1. Residues in the 5th module of the low-density lipoprotein receptor that bind apoE and apoB-100

    International Nuclear Information System (INIS)

    Kroon, P.A.; Zhang, H.-Y.; Smith, R.

    2000-01-01

    Full text: The low-density lipoprotein receptor (LDLR) binds and removes cholesterol-rich lipoproteins from the circulation. Its ligand-binding (LB) domain consists of seven cysteine-rich LB modules that bind apoB-100 and apoE. These modules fold into well-defined structures with three disulfide bonds, in the presence of Ca 2+ . The 5th module (LB5) is unique in that it is required to bind both apoB-100 and apoE. The aim of the current study was to map residues in human LB5 that are required for ligand binding. This was done by alanine mutagenesis of a series of residues that are conserved in human, mouse, rat and rabbit LB5 (E9, S14, E16, H19, S21, K31, and K33), but not in the other six modules. E37 (R37 in the rabbit) was included, since it has been previously hypothesized to play a role in binding. The variant LB5 modules were first produced as recombinant peptides, and subjected to oxidative folding to determine whether the mutations interfered with Ca 2+ '-dependent folding. Only the S14A and E16A mutations interfered significantly with folding, suggesting that S14 and E16 are required for the structural framework of LB5 and that their substitution in the LDLR may interfere with its folding. The native LDLR and E9A, H19A, S21A, K31A, K33A and E37A LDLRs were expressed in LDLR negative IdlA-7 CHO cells. Labeling with 125 I-lgG-C7 showed that all receptors were expressed on the cell surface. Binding of Dil-labeled LDL (Dil-LDL) and Dil-labeled DMPC, complexed with the N-terminal receptor-binding domain of apoE3 (Dil-E3), at 4 deg C, was used to assess receptor binding. Binding of Dil-E3 (0.1 μ/ml) to the H19A, S21A, K31A, K33A and E37A LDLRs was 65-92% of binding to the native LDLR. In contrast, the E9A LDLR only bound 3% of that of the native LDLR. The binding of Dil-LDL (0.5 Ag/ml) to the E9A LDLR was 23% of that of the native LDLR, while binding to the remaining variant LDLRs ranged from 44-70% of what of the native LDLR. We conclude that (i) E9 of LB5

  2. Renewing Head Start&apos;s Promise: Invest in What Works for Disadvantaged Preschoolers

    Science.gov (United States)

    Mead, Sara

    2014-01-01

    Since Head Start&apos;s last reauthorization in 2007, the Department of Health and Human Services, which oversees Head Start, has implemented significant reforms that are improving the program. In "Renewing Head Start&apos;s Promise: Invest in What Works for Disadvantaged Preschoolers," Sara Mead offers several recommendations to enable…

  3. A Failed Utopia in Marcela Del Río&apos;s "Proceso a Faubritten"

    Science.gov (United States)

    Manickam, Samuel

    2014-01-01

    In Marcela del Río&apos;s science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten&apos;s "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, María Corona. In my analysis of these two diaries, I will show how…

  4. Nuclear track radiography of &apos;hot&apos; aerosol particles

    Energy Technology Data Exchange (ETDEWEB)

    Boulyga, S.F.; Kievitskaja, A.I.; Kievets, M.K.; Lomonosova, E.M.; Zhuk, I.V.; Yaroshevich, O.I.; Perelygin, V.P.; Petrova, R.; Brandt, R.; Vater, P

    1999-06-01

    Nuclear track radiography was applied to identify aerosol &apos;hot&apos; particles which contain elements of nuclear fuel and fallout after Chernobyl NPP accident. For the determination of the content of transuranium elements in radioactive aerosols the measurement of the {alpha}-activity of &apos;hot&apos; particles by SSNTD was used in this work, as well as radiography of fission fragments formed as a result of the reactions (n,f) and ({gamma},f) in the irradiation of aerosol filters by thermal neutrons and high energy gamma quanta. The technique allowed the sizes and alpha-activity of &apos;hot&apos; particles to be determined without extracting them from the filter, as well as the determination of the uranium content and its enrichment by {sup 235}U, {sup 239}Pu and {sup 241}Pu isotopes. Sensitivity of determination of alpha activity by fission method is 5x10{sup -6} Bq per particle. The software for the system of image analysis was created. It ensured the identification of track clusters on an optical image of the SSNTD surface obtained through a video camera and the determination of size and activity of &apos;hot&apos; particles00.

  5. Energy saving retrofitting of a prefabricated panel construction kinder-garden - demonstration project &apos;'Plappersnut'&apos; in Wismar.; Energetische Sanierung einer Kindertagesstaette in Plattenbauweise - Demonstrationsbauvorhaben &apos;'Plappersnut'&apos; in Wismar

    Energy Technology Data Exchange (ETDEWEB)

    Wollensak, Heidi [Institut fuer Gebaeude + Energie + Licht Planung, Alter Holzhafen 19, 23966 Wismar (Germany); Wollensak, Martin [Hochschule Wismar, FG Baukonstruktion und Baustofftechnik (Germany); Roemhild, Thomas [Hochschule Wismar, FG Entwerfen, Gebaeude- Klima- und Lichtplanung (Germany); Mainka, Georg-Wilhelm; Winkler, Heiko [Lehrstuhl fuer Baukonstruktionen und Bauphysik, Institut fuer Bauingenieurwesen, Universitaet Rostock (Germany)

    2005-12-01

    The project &apos;&apos;kindergarten Plappersnut&apos;&apos; in Wismar focuses on cutting the energy consumption of the in 1972 build prefabricated plate construction down to one third by mainly 3 means: - improving the relation between building volume and outside surface by replacing the corridor building between the two main wings with a light membrane roof, covering the whole space, - eliminating energy loss through the building structure by coating the whole building with different isolation systems, - replacing all of the technical installation under the aspects of ecological energy supply and energy retrieving systems. The project was classed as a demonstration project of the EnSan-Program, supported by the German Ministry for Economy and Technology. (Abstract Copyright [2005], Wiley Periodicals, Inc.) [German] Das Sanierungsprojekt der 1972 in Plattenbauweise errichteten Kita &apos;'Plappersnut'&apos; stand im Zeichen der Reduzierung des Energiebedarfs auf ein Drittel durch drei wesentliche Massnahmen: - Verbesserung des Verhaeltnisses Gebaeudevolumen zu Aussenwandflaeche durch Entfernung der Verbindungsgaenge zwischen beiden Gebaeudeteilen und Ueberdachung des entstehenden Hofes mit einem Membrandach, - Verminderung der Energieverluste durch die Gebaeudehuelle mit Hilfe verschiedener Waermedaemm-Massnahmen, - Ersatz der gesamten Gebaeudetechnik durch energiesparende Systeme und unter Einsatz von erneuerbaren Energien. Das Projekt wurde im Rahmen des EnSan-Programms vom Bundesministerium fuer Wirtschaft und Technologie gefoerdert. (Abstract Copyright [2005], Wiley Periodicals, Inc.)

  6. Development and utilization of a mechanical barrier for large-calibre cavern necks. The &apos;&apos;Spider Plug&apos;&apos;; Entwicklung und Einsatz einer mechanischen Absperrung fuer grosskalibrige Kavernenhaelse. Der &apos;&apos;Spider Plug&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Pfeifer, K.; Maut, D. [UGS GmbH, Mittenwalde (Germany)

    2013-08-01

    An hydraulic separation of a well and the cavern can be necessary for different workover applications, e.g. casing milling or underreaming. The separation is needed to ensure a mud circulation during such operations. In that case a barrier is set after flooding the cavern, which will then be used as a mechanical abutment for the cement bridge. If the diameter of the cavern neck has been enlarged due to e.g. unwanted leaching processes or unstabilized underreaming processes, it might get impossible to set a standard plug with the available technologies into those diameters. Therefore UGS GmbH has developed a mechanical plug, which is set hydraulically. The so called &apos;Spider Plug&apos; is used as basis for a cement bridge and can be removed by drilling after the workover has been done. Depending on the dimension of the setting tool a cavern neck up to 50&apos;&apos; diameter can be plugged by the &apos;Spider Plug&apos;. Up to now a number of successful operations on different locations has shown, that the &apos;Spider Plug&apos; is a practicable and cost-efficient solution for a mechanical abutment of large cavern necks. (orig.)

  7. &apos;'Radio-oncomics'&apos;. The potential of radiomics in radiation oncology

    Energy Technology Data Exchange (ETDEWEB)

    Peeken, Jan Caspar; Nuesslin, Fridtjof [Technische Universitaet Muenchen (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Muenchen (Germany); Combs, Stephanie E. [Technische Universitaet Muenchen (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Muenchen (Germany); Helmholtz Zentrum Muenchen, Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Neuherberg (Germany)

    2017-10-15

    Radiomics, a recently introduced concept, describes quantitative computerized algorithm-based feature extraction from imaging data including computer tomography (CT), magnetic resonance imaging (MRT), or positron-emission tomography (PET) images. For radiation oncology it offers the potential to significantly influence clinical decision-making and thus therapy planning and follow-up workflow. After image acquisition, image preprocessing, and defining regions of interest by structure segmentation, algorithms are applied to calculate shape, intensity, texture, and multiscale filter features. By combining multiple features and correlating them with clinical outcome, prognostic models can be created. Retrospective studies have proposed radiomics classifiers predicting, e. g., overall survival, radiation treatment response, distant metastases, or radiation-related toxicity. Besides, radiomics features can be correlated with genomic information (&apos;'radiogenomics'&apos;) and could be used for tumor characterization. Distinct patterns based on data-based as well as genomics-based features will influence radiation oncology in the future. Individualized treatments in terms of dose level adaption and target volume definition, as well as other outcome-related parameters will depend on radiomics and radiogenomics. By integration of various datasets, the prognostic power can be increased making radiomics a valuable part of future precision medicine approaches. This perspective demonstrates the evidence for the radiomics concept in radiation oncology. The necessity of further studies to integrate radiomics classifiers into clinical decision-making and the radiation therapy workflow is emphasized. (orig.) [German] Radiomics beschreibt eine algorithmusbasierte Berechnung von Merkmalen auf Basis von Bilddatensaetzen einschliesslich Computertomographie (CT), Magnetresonanztomographie (MRT) und Positronenemissionstomographie (PET). Radiomics hat das Potenzial, die

  8. Improvement in remote sensing of low vegetation cover in arid regions by correcting vegetation indices for soil &apos;'noise'&apos;

    International Nuclear Information System (INIS)

    Escadafal, R.; Huete, A.

    1991-01-01

    The variations of near-infrared red reflectance ratios of ten aridic soil samples were correlated with a &apos;&apos;redness index&apos;&apos; computed from red and green spectral bands. These variations have been shown to limit the performances of vegetation indices (NDVI and SAVI) in discriminating low vegetation covers. The redness index is used to adjust for this &apos;&apos;soil noise&apos;&apos;. Dala simulated for vegetation densities of 5 to 15% cover showed that the sensitivity of the corrected vegetation indices was significantly improved. Specifically, the &apos;'noise-corrected'&apos; SAVI was able to assess vegetation amounts with an error four times smaller than the uncorrected NDVI. These promising results should lead to a significant improvement in assessing biomass in arid lands from remotely sensed data. (author) [fr

  9. Fundamental limitations on &apos;warp drive&apos; spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Lobo, Francisco S N [Centro de Astronomia e AstrofIsica da Universidade de Lisboa, Campo Grande, Ed. C8 1749-016 Lisbon (Portugal); Visser, Matt [School of Mathematical and Computing Sciences, Victoria University of Wellington, PO Box 600, Wellington (New Zealand)

    2004-12-21

    &apos;Warp drive&apos; spacetimes are useful as &apos;gedanken-experiments&apos; that force us to confront the foundations of general relativity, and among other things, to precisely formulate the notion of &apos;superluminal&apos; communication. After carefully formulating the Alcubierre and Natario warp drive spacetimes, and verifying their non-perturbative violation of the classical energy conditions, we consider a more modest question and apply linearized gravity to the weak-field warp drive, testing the energy conditions to first and second orders of the warp-bubble velocity, v. Since we take the warp-bubble velocity to be non-relativistic, v << c, we are not primarily interested in the &apos;superluminal&apos; features of the warp drive. Instead we focus on a secondary feature of the warp drive that has not previously been remarked upon-the warp drive (if it could be built) would be an example of a &apos;reaction-less drive&apos;. For both the Alcubierre and Natario warp drives we find that the occurrence of significant energy condition violations is not just a high-speed effect, but that the violations persist even at arbitrarily low speeds. A particularly interesting feature of this construction is that it is now meaningful to think of placing a finite mass spaceship at the centre of the warp bubble, and then see how the energy in the warp field compares with the mass-energy of the spaceship. There is no hope of doing this in Alcubierre&apos;s original version of the warp field, since by definition the point at the centre of the warp bubble moves on a geodesic and is &apos;massless&apos;. That is, in Alcubierre&apos;s original formalism and in the Natario formalism the spaceship is always treated as a test particle, while in the linearized theory we can treat the spaceship as a finite mass object. For both the Alcubierre and Natario warp drives we find that even at low speeds the net (negative) energy stored in the warp fields must be a significant fraction

  10. &apos;Green Isle&apos; on the &apos;Red Isle&apos;. The gasometer in Berlin becomes a centre of the &apos;European Energy Forum&apos;; &apos;Gruene Insel&apos; auf der &apos;Roten Insel&apos;. Der Berliner Gasometer wird zum Zentrum des &apos;Europaeischen Energie Forums&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ulf

    2013-06-01

    If the ARD political talk show with Guenther Jauch starts on Sunday night after the crime thriller, only few viewers know that they are tele-guests on the former gasometer site in Berlin-Schoeneberg. Currently, this site is being transformed into an environmentally friendly campus called the &apos;European Energy Forum&apos; (EUREF). According to the will of the owner and architect Reinhard Mueller, the campus will become the largest CO{sub 2} neutral office and business location in Europe. Totally 600 million Euro will be invested. All new buildings should be ecological &apos;green buildings&apos; and received the LEED Gold certification.

  11. Design Concept of a Seal-off Type 14 MeV Neutron Generator of 10&apos;&apos;1&apos;&apos;1n/s Range

    Energy Technology Data Exchange (ETDEWEB)

    In, S. R.; Oh, B. H. [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    The total neutron fluence during the life time is expected to be around 10MW·yr/m&apos;&apos;2 which may cause a damage of -100 dpa in materials. To estimate the adaptability of candidate materials in a few years, a 14MeV neutron source with a flux level of 3 - 5 x 10&apos;&apos;1&apos;&apos;8 n/s·m&apos;&apos;2, which is the goal of the IFMIF facility costing more than ¤1000M, is necessitated. The problem in making an intense neutron generator of beam target type is really not on the neutron production rate, but on the huge heat generated in the target, because the fusion power is only one of thousands of beam power exerted on the target. We have a plan to develop neutron generators step by step from a 10&apos;&apos;8 n/s level. The final goal is establishing a 14MeV neutron irradiation facility at 10&apos;&apos;1&apos;&apos;4 intensity level.. Up to the 10&apos;&apos;1&apos;&apos;0 n/s level, there occurs basically no critical thermal problem, because beam power density is in the range of tens W/cm&apos;&apos;2. The neutron generator designed in a sealed-off type because of tritium safety is mainly composed of an ion source, target, reaction chamber, and getter pump.. The major design concepts for the neutron generator with the neutron production rate of 10&apos;&apos;1&apos;&apos;1 n/s range were presented. The specifications of the ion source, target and getter have been determined for attaining the goal of the neutron generation rate.

  12. Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice

    Directory of Open Access Journals (Sweden)

    Zhao Yarui

    2011-01-01

    Full Text Available Abstract Background Sphingomyelin synthase 2 (SMS2 contributes to de novo sphingomyelin (SM biosynthesis. Its activity is related to SM levels in the plasma and the cell membrane. In this study, we investigated the possibility of a direct relationship between SMS and atherosclerosis. Methods The Adenovirus containing SMS2 gene was given into 10-week ApoE KO C57BL/6J mice by femoral intravenous injection. In the control group, the Adenovirus containing GFP was given. To confirm this model, we took both mRNA level examination (RT-PCR and protein level examination (SMS activity assay. Result We generated recombinant adenovirus vectors containing either human SMS2 cDNA (AdV-SMS2 or GFP cDNA (AdV-GFP. On day six after intravenous infusion of 2 × 1011 particle numbers into ten-week-old apoE KO mice, AdV-SMS2 treatment significantly increased liver SMS2 mRNA levels and SMS activity (by 2.7-fold, 2.3-fold, p Conclusions Our results present direct morphological evidence for the pro-atherogenic capabilities of SMS2. SMS2 could be a potential target for treating atherosclerosis.

  13. Werner Jaeger&apos;s "Paideia" and His &apos;Third Humanism&apos;

    Science.gov (United States)

    Horn, Christoph

    2018-01-01

    Werner Jaeger (1888-1961) was at his time the most brilliant and the most influential German classicist. His most important project was a tripartite study that he finally published under the title of "Paideia. Die Formung des griechischen Menschen" (1933-1947). "Paideia" was much more than a detailed scholarly book on pedagogy…

  14. Comment on &apos;&apos;Teleportation of two-mode squeezed states&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    He Guangqiang; Zhang Jingtao [State Key Lab of Advanced Optical Communication Systems and Networks Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030 (China)

    2011-10-15

    We investigate the teleportation scheme of two-mode squeezed states proposed by Adhikari et al.[S. Adhikari et al., Phys. Rev. A 77, 012337 (2008)]. It uses four-mode entangled states to teleport two-mode squeezed states. The fidelity between the original two-mode squeezed states and teleported ones is calculated. The maximal fidelity value of Adhikari&apos;s protocol is 0.38, which is incompatible with the fidelity definition with the maximal value 1. In our opinion, one reason is that they calculate the fidelity for multimodes Gaussian states using the fidelity formula for single-mode ones. Another reason is that the covariance matrix of output states should be what is obtained after applying the linear unitary Bogoliubov operations (two cascaded Fourier transformations) on the covariance matrix given in Eq. (12) in their paper. These two reasons result in the incomparable results. In addition, Adhikari&apos;s protocol can be simplified to be easily implemented.

  15. Technology &apos;90

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The US Department of Energy (DOE) laboratories have a long history of excellence in performing research and development in a number of areas, including the basic sciences, applied-energy technology, and weapons-related technology. Although technology transfer has always been an element of DOE and laboratory activities, it has received increasing emphasis in recent years as US industrial competitiveness has eroded and efforts have increased to better utilize the research and development resources the laboratories provide. This document, Technology &apos;90, is the latest in a series that is intended to communicate some of the many opportunities available for US industry and universities to work with the DOE and its laboratories in the vital activity of improving technology transfer to meet national needs. Technology &apos;90 is divided into three sections: Overview, Technologies, and Laboratories. The Overview section describes the activities and accomplishments of the DOE research and development program offices. The Technologies section provides descriptions of new technologies developed at the DOE laboratories. The Laboratories section presents information on the missions, programs, and facilities of each laboratory, along with a name and telephone number of a technology transfer contact for additional information. Separate papers were prepared for appropriate sections of this report.

  16. The First Synthesis and Anti-retroviral Activity of 5&apos;,5&apos;-Difluoro-3&apos;-Hydroxy-Apiosyl Nucleoside Cyclomonophosphonic Acid Analogs

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seyeon; Hong, Joon Hee [Chosun University, Gwangju (Korea, Republic of)

    2016-04-15

    The first synthesis of novel 5&apos;,5&apos;-difluoro-30-hydroxy apiose nucleoside cyclomonophosphonic acid analogs was performed as potent anti-retroviral agents. Phosphonation was performed by direct displacement of a triflate intermediate with diethyl(lithiodifluoromethyl) phosphonate to give the corresponding(α, α-difluoroalkyl) phosphonate. Condensation successfully proceeded from a glycosyl donor with persilylated bases to yield the nucleoside phosphonate analogs. Deprotection of diethyl phosphonates provided the target nucleoside cyclomonophosphonic acid analogs. The synthesized nucleoside analogs were subjected to anti-viral screening against the human immunodeficiency virus-1 (HIV-1). Cytosine analogs show significant anti-HIV activity.

  17. Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.

    Science.gov (United States)

    Kameyama, Hirokazu; Nakajima, Hiroyuki; Nishitsuji, Kazuchika; Mikawa, Shiho; Uchimura, Kenji; Kobayashi, Norihiro; Okuhira, Keiichiro; Saito, Hiroyuki; Sakashita, Naomi

    2016-07-28

    The single amino acid mutation G26R in human apolipoprotein A-I (apoA-IIowa) is the first mutation that was associated with familial AApoA1 amyloidosis. The N-terminal fragments (amino acid residues 1-83) of apoA-I containing this mutation deposit as amyloid fibrils in patients' tissues and organs, but the mechanisms of cellular degradation and cytotoxicity have not yet been clarified. In this study, we demonstrated degradation of apoA-IIowa fibrils via the autophagy-lysosomal pathway in human embryonic kidney 293 cells. ApoA-IIowa fibrils induced an increase in lysosomal pH and the cytosolic release of the toxic lysosomal protease cathepsin B. The mitochondrial dysfunction caused by apoA-IIowa fibrils depended on cathepsin B and was ameliorated by increasing the degradation of apoA-IIowa fibrils. Thus, although apoA-IIowa fibril transport to lysosomes and fibril degradation in lysosomes may have occurred, the presence of an excess number of apoA-IIowa fibrils, more than the lysosomes could degrade, may be detrimental to cells. Our results thus provide evidence that the target of apoA-IIowa fibrils is lysosomes, and we thereby gained a novel insight into the mechanism of AApoA1 amyloidosis.

  18. The energy and monetary implications of the &apos;24/7&apos; &apos;always on&apos; society

    Energy Technology Data Exchange (ETDEWEB)

    Loveday, Dennis L. [Department of Civil and Building Engineering, Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom)], E-mail: d.l.loveday@lboro.ac.uk; Bhamra, T.; Tang, T. [Department of Design and Technology, Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Haines, V.J.A. [Ergonomics and Safety Research Institute (ESRI), Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Holmes, M.J. [ARUP, 13, Fitzroy Street, London W1T 4BR (United Kingdom); Green, R.J. [Institute for Energy Research and Policy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)

    2008-12-15

    This paper reviews the trends in society, technology and energy demand of the past 30 years, together with the growth of the &apos;on-demand&apos; culture. The &apos;24/7&apos; or &apos;always on&apos; society can be defined as one where people demand-and generally receive-what they want &apos;now&apos;. It has grown up in parallel with developments in information technology, which have produced the services needed to meet that demand. Larger numbers of appliances, resulting from greater affluence and disposable income, have increased energy use, despite energy efficiencies in other areas. While monetary factors suggest that changes brought about by the 24/7 society will generally be self-correcting at the macro-economic level, there will nevertheless be effects for individuals, such as potentially severe impacts on the fuel poor as electricity prices rise. We conclude with a view of future directions. As the 24/7 culture continues to grow, there is scope for designers and for information technology to manage and reduce energy consumption. This includes buildings, their services systems, and the mix of new technologies that will be deployed over the next 20 years or so, including the possibilities for data exchange and control at the interface between energy suppliers and consumers, coupled with greater understanding of the behaviour of the consumers themselves.

  19. Vertiefungskurs 2014. Safety margins in nuclear power plants. Identify, quantify and extend; Vertiefungskurs 2014 zum Thema &apos;&apos;Sicherheitsmargen in Kernkraftwerken. Identifizieren, quantifizieren, erweitern&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rey, Matthias

    2015-02-15

    Fifteen speakers dealt with the topic safety margins in nuclear power plants from different points of view at the &apos;&apos;Vertiefungskurs 2014&apos;&apos; of the Nuklearforum Schweiz in Olten, 4 and 5 November 2014. In the context of the &apos;&apos;Vertiefungskurs 2014&apos;&apos; the safety margins in power plants were considered and quantified and possible extensions have been discussed. The conference started with an in-depth introduction of the basis design of existing nuclear power plants. Thereafter speakers told about the main topics emergency preparedness, knowledge management and safety retrofit of nuclear power plants in operation.

  20. The &apos;electric power&apos; experience: Between nostalgia and the future. Erlebnis &apos;Strom&apos; zwischen Nostalgie und Zukunft

    Energy Technology Data Exchange (ETDEWEB)

    Moergeli, H.P. (Moergeli und Partner, Muri bei Bern (Switzerland))

    1994-03-04

    The &apos;'Muehleberg'&apos; is a concept which is mostly used in connection with the nuclear power station. But there is more to the &apos;'Muehleberg'&apos; than at first sight. A hydroelectric station, a waste dump gas plant and the brandnew works management centre of the Bernische Kraftwerke AG (BKW) constitute the framework for a host of other attractions in the field of electric power; among others, examples of technological culture in the BKW museum, which are worth seeing. (orig.)

  1. Radio frequency and electromagnetic fields exposure, health risk; Esposizione dell&apos;uomo ai campi elettromagnetici prodotti dai sistemi di telefonia cellulare

    Energy Technology Data Exchange (ETDEWEB)

    Bernardi, P.; Cavagnaro, P.; Pisa, S.; Piuzzi, E. [Rome Unvi. (Italy). Dipt. di Ingegneria Elettronica

    1999-08-01

    Health risk for humane exposure at electromagnetic field generate from mobile telephones is very particular. In this work are presented the most important results of research. [Italian] La protezione dell&apos;uomo dall&apos;esposizione di campi elettromagnetici prodotti dai sistemi di telefonia mobile presenta caratteristiche del tutto particolari. Bisogna infatti considerare un duplice apetto: da un lato l&apos;esposizione della popolazione ai campi prodotti dalle antenne trasmittenti delle stazioni radio base e, dall&apos;altro, l&apos;esposizione del singolo utente all&apos;apparato portatile. Insieme all&apos;esame di tali problemi, in questo lavoro vengono presentati i risultati piu&apos; significativi delle ricerche fino ad oggi sviluppate per fornire una base razionale alle normative di protezione e si accenna all&apos;attuale evoluzione della ricerca nel campo.

  2. Global climate change in the Earth&apos;s history: The cretaceous period was a period of greenhouse climate; Klimawandel in der Erdgeschichte: Kreidezeit war Treibhauswelt

    Energy Technology Data Exchange (ETDEWEB)

    Mutterlose, J.; Immenhauser, A. [Bochum Univ. (Germany). Inst. fuer Geologie, Mineralogie und Geophysik, Sediment- und Isotopengeologie/Geobiologie

    2007-07-01

    The impending global warning is one of the biggest challenges to be faced by humanity. A look back into Earth&apos;s history may be useful for describing and understanding the future scenario. Paleooceanographers, paleontologists and sedimentologists analyze the climates throughout Earth history, in which there were several periods of &apos;greenhouse conditions&apos;. (orig.)

  3. Increased CSF-BACE 1 Activity Is Associated with ApoE-[Epsilon]4 Genotype in Subjects with Mild Cognitive Impairment and Alzheimer's Disease

    Science.gov (United States)

    Ewers, Michael; Zhong, Zhenyu; Burger, Katharina; Wallin, Anders; Blennow, Kaj; Teipel, Stefan J.; Shen, Yong; Hampel, Harald

    2008-01-01

    The Apolipoprotein (ApoE) [epsilon]4 allele is a major genetic risk factor of Alzheimer's disease, and may affect the production of amyloid beta (A[beta][subscript 1-42]). Recently, we have shown that [beta]-secretase (BACE 1) activity can be reliably detected within the brain and human CSF. Here, we have examined an association between the ApoE…

  4. Quarks: Two&apos;s company, three a crowd?

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Last year, careful measurements by the experiments studying electron positron annihilation in CERN&apos;s new LEP ring and at Stanford&apos;s SLC linear collider showed that the conventional list of the basic constituents of matter is complete. Three types of particles (electron, muon and tau) interacting under the weak nuclear force are linked to six quarks - the constituents of nuclear matter - grouped pairwise into three distinct families (&apos;up&apos; and &apos;down&apos;, &apos;strange&apos; and &apos;charm&apos;, &apos;beauty&apos; and &apos;top&apos;). The question now is to understand why this sixquark model works

  5. Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice

    DEFF Research Database (Denmark)

    Reverte, Ingrid; Klein, Anders Bue; Ratner, Cecilia

    2012-01-01

    , very little information is available on apoE2 genotype. In the present study, we have characterized behavioral and learning phenotypes in young transgenic mice apoE2, apoE3 and apoE4 of both sexes. We have also determined the levels of brain-derived neurotrophic factor (BDNF) and its receptor Trk...

  6. Monitoring the degradation and solubilisation of butyltin compounds during in vitro gastrointestinal digestion using &apos;&apos;triple spike&apos;&apos; isotope dilution GC-ICP-MS

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez-Gonzalez, Pablo; Encinar, Jorge Ruiz; Alonso, J. Ignacio Garcia; Sanz-Medel, Alfredo [Department of Physical and Analytical Chemistry, Oviedo (Spain). Faculty of Chemistry

    2005-01-01

    An in vitro gastrointestinal digestion approach in combination with species-specific isotope dilution analysis has been employed for the first time to study the transformation reactions as well as the solubilisation of butyltin species throughout a simulated human digestion. Different sample preparation procedures were assayed in order to avoid problems derived from lack of isotope equilibration between the endogenous and the isotopically-enriched added species. A &apos;&apos;triple spike&apos;&apos; approach, which can be used to calculate the corrected concentrations of mono-, di-, and tributyltin (MBT, DBT and TBT, respectively), as well as six interconversions, was employed throughout this work. In order to calculate and compare the species degradation factors, a triple spike solution containing each butyltin species enriched in a different isotope was added to the simulated gastric and intestinal fluids before the digestion procedures in the presence and in the absence of a solid biological matrix (commercial mussel tissue). Additionally, by analysing the soluble and insoluble fractions resulting from the simulated digestion of a commercial mussel tissue (gastric and gastric plus intestinal digestion), total mass balances for each butyltin compound could be derived. For this purpose, the isotopically-enriched species were added after the enzymatic digestions in order to avoid problems derived from lack of isotope equilibration. The mass balances provided information not only about the solubilisation but also about the degradation of the butyltin species during the digestion procedures. Good agreement between the degradation factors calculated under all experiments performed in this work and between those reported in previous works were obtained. The most serious degradation observed was that of DBT to produce MBT, whereas slight degradations of TBT and MBT were detected. Moreover, a worrying 61% of the original total butyltin content present in a commercial

  7. Tomorrow&apos;s Energy Stakes

    International Nuclear Information System (INIS)

    Perrin, Francis

    2010-01-01

    Energy is certainly one of the primary sectors subjected to prospective analysis. Considering that world energy production is essentially based on fossil fuels, it is imperative that humanity uncovers new options and solutions. However, alternative energies remain underdeveloped, mainly because of their investment cost, but also because traditional energy represents an important source of income for certain companies and governments. In this article, Francis Perrin analyses global energy trends throughout the next decades (rise of the emerging countries&apos; consumption, use of renewable energies and unconventional gas) and their impact on the energy market, the planet and in international relations

  8. Breeding ground: evolving the &apos;smart&apos; industry

    Energy Technology Data Exchange (ETDEWEB)

    Jaremko, G.

    2001-05-01

    This article celebrates the successes of the Canadian independent oil contractors and the oilfield service and supply sector that keep Canada in the forefront of the world&apos;s &apos;smart&apos; nations in energy stewardship, efficiency, development, diversification and utilization. It explains how small independent contractors and service and supply enterprises play a central role on all these fronts, with supply and service companies being responsible for about 80 per cent of oil companies&apos; capital budget and 70 per cent of their operational expenditures in fields ranging from construction, and camp catering, to ambulance services, safety systems, trucking, tool making, drilling services, production testing, valve manufacturing, chemical blending and environmental protection. Special attention is paid to importance on independent contractors represented by the Small Explorers and Producers Association of Canada (SEPAC), their ability to develop or adopt new technology and to accommodate the demands of constantly changing price levels and increasingly higher expectations in terms of social responsibility, productivity and competitiveness, as well as environmental performance. As an example, the article describes the career of Robert Tessari, founder and president of Tesco Corporation, a drilling company operating in some 40 countries, who aims to automate drilling to the point where rig crews are pared to teams of two or three experts directing machinery from computer consoles. That he is well on the way of achieving his objectives is illustrated by his contributions to the development of a new generation of bits, tools and procedures known as the &apos;case drilling&apos; process which simultaneously uses the same steel tubing to make the holes into oil and gas-bearing formations and line them for production, and in so doing cut 25 to 30 per cent off the time required to drill a well and bring it to production. His company&apos;s contribution to the

  9. Effectiveness of human factors simulator

    International Nuclear Information System (INIS)

    Moragas, F.

    2015-01-01

    En 2011, ANAV started the exploitation of the Human Factors Simulator installed in TECNATOM Training Center located in L&apos;Hospital de L&apos;Infant Tarragona. AVAN&apos;s Strategic Plan includes the Action Plan for the improvement of human behavior. The plan includes improving the efficiency of the efficiency of the human factors simulator. It is proposed to improve the efficiency into two different terms: winning effectiveness in modeling behaviors, and interweaving the activities in the simulator with the actual strategy of promoting Safety culture and human behaviour. (Author)

  10. Hair analysis in environmental medicine. Statement of the commission &apos;'Human-Biomonitoring'&apos; in the Federal Environmental Agency; Haaranalyse in der Umweltmedizin. Stellungnahme der Kommission &apos;'Human-Biomonitoring'&apos; des Umweltbundesamtes

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2006-07-01

    In environmental medicine it is important to have easily accessible materials, that reflect medial long-term exposition. Against this background hair is used to monitor internal exposure to metals and metalloids in epidemiological and case studies. Although hair analysis is of limited value for the quantification of exposure to pollutants, it is still widely used. The commision has therefore throroughly evaluated the difficulties of hair analysis and gives recommendations. (uke)

  11. Preferential Interactions between ApoE-containing Lipoproteins and Aβ Revealed by a Detection Method that Combines Size Exclusion Chromatography with Non-Reducing Gel-shift

    Science.gov (United States)

    LaDu, Mary Jo; Munson, Gregory W.; Jungbauer, Lisa; Getz, Godfrey S.; Reardon, Catherine A.; Tai, Leon M.; Yu, Chunjiang

    2012-01-01

    The association between apolipoprotein E (apoE) and amyloid-β peptide (Aβ) may significantly impact the function of both proteins, thus affecting the etiology of Alzheimer’s disease (AD). However, apoE/Aβ interactions remain fundamentally defined by the stringency of the detection method. Here we use size exclusion chromatography (SEC) as a non-stringent approach to the detection of apoE/Aβ interactions in solution, specifically apoE and both endogenous and exogenous Aβ from plasma, CSF and astrocyte conditioned media. By SEC analysis, Aβ association with plasma and CNS lipoproteins is apoE-dependent. While endogenous Aβ elutes to specific human plasma lipoproteins distinct from those containing apoE, it is the apoE-containing lipoproteins that absorb excess amounts of exogenous Aβ40. In human CSF, apoE, endogenous Aβ and phospholipid elute in an almost identical profile, as do apoE, exogenous Aβ and phospholipid from astrocyte conditioned media. Combining SEC fractionation with subsequent analysis for SDS-stable apoE/Aβ complex reveals that apoE-containing astrocyte lipoproteins exhibit the most robust interactions with Aβ. Thus, standardization of the methods for detecting apoE/Aβ complex is necessary to determine its functional significance in the neuropathology characteristic of AD. Importantly, a systematic understanding of the role of apoE-containing plasma and CNS lipoproteins in Aβ homeostasis could potentially contribute to identifying a plasma biomarker currently over-looked because it has multiple components. PMID:22138302

  12. Young Children&apos;s Interest in Live Animals

    Science.gov (United States)

    LoBue, Vanessa; Bloom Pickard, Megan; Sherman, Kathleen; Axford, Chrystal; DeLoache, Judy S.

    2013-01-01

    Animals are important stimuli for humans, and for children in particular. In three experiments, we explored children&apos;s affinity for animals. In Experiment 1, 11- to 40-month-old children were presented with a free-play session in which they were encouraged to interact with several interesting toys and two live animals--a fish and a hamster.…

  13. Study of the migration of radioactive elements in soils &apos;'in-place'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bovard, P.; Grauby, A.

    The problems of medium protection against radioactive contamination hazards have led the Commissariat a l&apos;Energie Atomique--Service de Controle des Radiations et de Genie Radioactif to study the behavior of ions in soils. There are many theoretical researches and laboratory studies on the movement of radioelements in soil. But, with the difficulties for obtaining a similar result in field, we have developed a simple direct method of in place soil contamination. However, a principal drawback remains, the necessity to extrapolate from one or two reduced size samples to a large area. This is all the problem of sampling, which is not specific of our method. However, a choice justified by classical data, let us obtain a sufficient number of results and an accuracy which is suitable.

  14. Results of the Danish &apos;&apos;high efficiency motors campaign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Malmose, K.

    2000-07-01

    In Denmark energy consultancy (demand side management activities (DSM)) took its first steps in the middle of the 80&apos;ies. The energy consultancy was built up around the Danish electric utilities on which the Danish government imposed the implementation of energy savings for funds collected through the electricity bill (approx. 0.0006 DKK/kWh corresponding to approx. 0.001 ECU). The electric utilities trained energy consultants who specialised in visiting industrial enterprises and counselling on energy consumption, primarily focusing on auxiliary systems like lighting, compressed air, ventilation and heating. Within these areas large savings could be obtained because each company was focusing on the actual production but also because the cost of energy was a fraction of the total costs. (orig.)

  15. &apos;&apos;Textural analysis of multiparametric MRI detects transition zone prostate cancer&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Sidhu, Harbir S.; Johnston, Edward W.; Taylor, Stuart A.; Halligan, Steve [Centre for Medical Imaging, University College London, London (United Kingdom); University College London Hospitals NHS Foundation Trust, London (United Kingdom); Benigno, Salvatore; Dikaios, Nikos [Centre for Medical Imaging, University College London, London (United Kingdom); Ganeshan, Balaji [Institute of Nuclear Medicine, University College London, University College Hospital, London (United Kingdom); Allen, Clare; Kirkham, Alex [University College London Hospitals NHS Foundation Trust, London (United Kingdom); Groves, Ashley M. [University College London Hospitals NHS Foundation Trust, London (United Kingdom); Institute of Nuclear Medicine, University College London, University College Hospital, London (United Kingdom); Ahmed, Hashim U.; Emberton, Mark [University College London Hospitals NHS Foundation Trust, London (United Kingdom); University College London, Research Department of Urology, London (United Kingdom); Punwani, Shonit [Centre for Medical Imaging, University College London, London (United Kingdom); University College London Hospitals NHS Foundation Trust, London (United Kingdom); Centre for Medical Imaging, University College London and University College London Hospitals NIHR Biomedical Research Centre, London (United Kingdom)

    2017-06-15

    To evaluate multiparametric-MRI (mpMRI) derived histogram textural-analysis parameters for detection of transition zone (TZ) prostatic tumour. Sixty-seven consecutive men with suspected prostate cancer underwent 1.5T mpMRI prior to template-mapping-biopsy (TPM). Twenty-six men had &apos;significant&apos; TZ tumour. Two radiologists in consensus matched TPM to the single axial slice best depicting tumour, or largest TZ diameter for those with benign histology, to define single-slice whole TZ-regions-of-interest (ROIs). Textural-parameter differences between single-slice whole TZ-ROI containing significant tumour versus benign/insignificant tumour were analysed using Mann Whitney U test. Diagnostic accuracy was assessed by receiver operating characteristic area under curve (ROC-AUC) analysis cross-validated with leave-one-out (LOO) analysis. ADC kurtosis was significantly lower (p < 0.001) in TZ containing significant tumour with ROC-AUC 0.80 (LOO-AUC 0.78); the difference became non-significant following exclusion of significant tumour from single-slice whole TZ-ROI (p = 0.23). T1-entropy was significantly lower (p = 0.004) in TZ containing significant tumour with ROC-AUC 0.70 (LOO-AUC 0.66) and was unaffected by excluding significant tumour from TZ-ROI (p = 0.004). Combining these parameters yielded ROC-AUC 0.86 (LOO-AUC 0.83). Textural features of the whole prostate TZ can discriminate significant prostatic cancer through reduced kurtosis of the ADC-histogram where significant tumour is included in TZ-ROI and reduced T1 entropy independent of tumour inclusion. (orig.)

  16. EUGRIS: &apos;&apos;European Substainable Land and Groundwater Management Information System&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Frauenstein, J. [Federal Environmental Agency (UBA), Berlin (Germany)

    2003-07-01

    The presentation outlines and Accompanying Measure with the FP 5 to develop an web based EUropean Sustainable Land and GRoundwater Management Information System information system (EUGRIS). The management of contaminated land and groundwater requires an interdisciplinary approach and a considerable amount of supporting technical information and knowledge. EUGRIS will provide a generally available comprehensive and overarching information and innovation resource, to support both research and practical contaminated land and groundwater management. EUGRI is a gateway to provide a &apos;one stop shop&apos; for information provided by research projects, legislation, standards, best practice and other technical guidance and policy/regulatory publications from the EC, participating Member and Accession States and from various international networks dealing with groundwater and land management issues. Different types of user can access information through different windows according to their needs. EUGRIS will provide its visitors with summary information (digests) and links to sources of more detailed and/or original information in a scaleable holistic and contexturally meaningful way. EUGRIS is being built in three stages: the design of the information system, the development of its software implementation, and the population of the system with information. The presentation is focussed on the concept of the development of the information system with the individual work packages. In the second part of the lecture in particular the work procedures are presented for the content wise replenishment by EUGRIS. The data collation for the proven pilot countries and the production of a European research data base, which opens contents and results of European-wide locked and current projects, form the emphasis thereby. (orig.)

  17. Documentation to the workshop &apos;Cluster in the environmental protection economy&apos;; Dokumentation zum Workshop &apos;&apos;Cluster in der Umweltschutzwirtschaft&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-12-11

    Within the workshop &apos;Cluster in the environmental protection economy&apos; at the Umweltbundesamt (Dessau-Rosslau, Federal Republic of Germany) at 27th November, 2008, the following lectures were held: (a) Which contribution can cluster and cluster politics contribute to the promotion of the environmental protection economy? (Harald Legler); (b) Cluster in the environmental protection economy: Targets and expectations (Dieter Rehfeld); (c) Demands at the management of clusters (Karin Hoerhan); (d) Demands at the cluster politics in the environmental protection economy (Bernhard Hausberg); (e) Photovoltaics in Eastern Germany (Johann Wackenbauer); (f) Automotive industry in Bergisches Land (Thomas Lemken); (g) Competence centre environment Augsburg-Schwaben (Egon Beckord).

  18. Report of Activity, 1997; Rapport d&apos;activite, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Lacoste, Andre-Claude; Livolant, Michel [eds.] [Inst. de Protection et de Surete Nucleaire, CEA Centre d' Etudes de Fontenay-aux-Roses, 92 (France)

    1998-07-01

    The Institute of Nuclear Protection and Safety (Institut de Protection et de Surete Nucleaire) - IPSN carries out research and expert studies needed in managing nuclear risk and consequences of nuclear events on population and environment, i.e. supervises the safety of installations, the prevention and study of accidents, the human health and environmental conditions, the safety of transport and has also the task of organizing the management of the crisis situations. IPSN has the mission of informing the public and participates in numerous international actions. Thus, since 1989 IPSN and its German counterpart, GRS, co-operate towards improving of the nuclear safety in Europe and developing a common approach of international issues. As acting for public authorities (government departments in charge with industry, environment, health or labor), IPSN grants technical authorizations on request of DSIN exploiters. The IPSN personnel amounts up to 1300 employees of whom around two thirds are engineers, researchers, physicians, agronomists, and veterinarians. This IPSN annual report contains in the &apos;Free Tribune&apos; section two general papers entitled: &apos;The federalist role of research at IPSN&apos; by Catherine Lecompte and &apos;The dose, a central issue in radioprotection debates&apos; by Annie Sugier. Then five sub-reports follow: 1.The safety of nuclear facilities and radioactive wastes; 2.Crisis management; 3. The management of sensitive materials (protection and control of sensitive materials and safety analysis of the radioactive materials transport); 4.Protection of human health; 5.Environment protection. The report also presents the international activities, the cooperation IPSN/GRS, the budget, the staff and the human resource policy and the communication activity.

  19. SOLAR MAGNETIZED &apos;TORNADOES&apos;: RELATION TO FILAMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Su Yang; Veronig, Astrid; Temmer, Manuela [IGAM-Kanzelhoehe Observatory, Institute of Physics, University of Graz, Universitaetsplatz 5, A-8010 Graz (Austria); Wang Tongjiang [Department of Physics, Catholic University of America, Washington, DC 20064 (United States); Gan Weiqun, E-mail: yang.su@uni-graz.at [Key Laboratory of Dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China)

    2012-09-10

    Solar magnetized &apos;tornadoes&apos;, a phenomenon discovered in the solar atmosphere, appear as tornado-like structures in the corona but are rooted in the photosphere. Like other solar phenomena, solar tornadoes are a feature of magnetized plasma and therefore differ distinctly from terrestrial tornadoes. Here we report the first analysis of solar &apos;tornadoes&apos; (two papers which focused on different aspects of solar tornadoes were published in the Astrophysical Journal Letters and Nature, respectively, during the revision of this Letter). A detailed case study of two events indicates that they are rotating vertical magnetic structures probably driven by underlying vortex flows in the photosphere. They usually exist as a group and are related to filaments/prominences, another important solar phenomenon whose formation and eruption are still mysteries. Solar tornadoes may play a distinct role in the supply of mass and twists to filaments. These findings could lead to a new explanation of filament formation and eruption.

  20. The implementation of the &apos;&apos;Smart Grid&apos;&apos; - preached but not practised; Die Realisierung des &apos;&apos;Smart Grids&apos;&apos;. In aller Munde, aber nicht in der Umsetzung

    Energy Technology Data Exchange (ETDEWEB)

    Augenstein, Friedrich [Duale Hochschule Baden-Wuerttemberg, Stuttgart (Germany). Bereich BWL-Dienstleistungsmanagement; Einhellig, Ludwig; Kohl, Ingmar [Deloitte, Muenchen (Germany)

    2011-07-15

    The development of smart power grids is still in its infancy in Germany, in spite of extensive pilot programmes, competition from foreign power suppliers as well as unanimous opinion among experts that there is no way around them. Although a legal obligations has existed since the beginning of this year to offer &apos;'variable-load'&apos; tariffs, and despite their being desired by the political realm and having been laid down in the Energy Concept of the Federal Government, lack of consumer demand has so far inhibited the development of intelligent grids. But is it really because of the consumer, or is it more due to other parameters that Germany is threatening to lose the race in smart grid technology.

  1. The &apos;Energy transition&apos; generation

    International Nuclear Information System (INIS)

    Bedossa, Bastien; Boutignon, Gregoire; Sivy, Corentin; Bercault, Florian; Cage, Agathe; Mahammedi-Bouzina, Mehdi; Potton, Gregoire

    2015-11-01

    The &apos;Cartes sur table&apos; think tank aims at leveraging the opinion of young French people (from 20 to 35 years old) politically leaning to the left, in order to let them become actors in French debates, such as the one on the energy transition policy for a &apos;green growth&apos;. This paper explains the origins and the context of the energy transition policy (the dangers of nuclear power, the high potential of renewable energies, etc.), how to finance the energy transition policy, how to promote energy transition in the daily life (notably in transports and through the struggle against wastage), create a Europe of energy, and so on

  2. Metrology for the radiological early warning system in Europe. The &apos;'MetroERM'&apos; project; Metrologie fuer die radiologischen Fruehwarnsysteme in Europa. Das &apos;'MetroERM'&apos;-Projekt

    Energy Technology Data Exchange (ETDEWEB)

    Neumaier, Stefan; Dombrowski, Harald [Physikalisch-Technische Bundesanstalt, Braunschweig (Germany)

    2017-10-01

    In the European radiological early warning system about 5500 stationary sensors are actually implemented that measure continuously the local dose rate. Alongside several hundred air dust collecting systems attribute to the measurement of airborne radioactivity. The local dose rates are transmitted hourly to a central data base that is operated on behalf of the EU commission. In significantly larger time intervals the measured data of the airborne radioactivity are transmitted. In case of a cross-border radiological accident these data are the basis for recommendations given by the EU commission to the member states for national counter measures. The focus of the project &apos;&apos;Metrology for radiological early warning networks in Europe&apos;&apos; is an improvement of the metrological quality and harmonization these data and the development of improved measuring systems and evaluation methods.

  3. Swiss &apos;Electricity&apos; Research Programme 2004-2007; Konzept des Forschungsprogramms &apos;Elektrizitaet&apos; 2004 - 2007

    Energy Technology Data Exchange (ETDEWEB)

    Brueniger, R.

    2004-07-01

    This report issued by the Swiss Federal Office of Energy (SFOE) provides details on Swiss research in the electricity area that is foreseen for the period 2004-2007. The report discusses the current state of electricity research and the strategic goals for the period and presents the organisations involved and their previous work. The general main areas of interest addressed by the programme are noted, such as the storage and transport of electricity as well as its use in communication technologies, motors, domestic appliances and industrial applications. Figures are presented on the programme&apos;s finances and the concept of &apos;trend-watching&apos; groups is briefly addressed.

  4. SKI&apos;s research strategy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    SKI&apos;s research is a prerequisite for SKI&apos;s ability to fulfil its assignment. Research to support supervision is focused today on a number of strategically important areas such as reactor technology, material and fuel questions, human factors, waste and non-proliferation (safeguards). SKI&apos;s intelligence analysis shows that this focus should be maintained over the next few years. Some reallocation of priorities between research areas may be necessary due to changes in the nuclear area. For this research, SKI contracts universities as well as consulting companies. The resources that are of importance for nuclear research are concentrated to a few organisations in Sweden. But the national research resources alone do not cover the existing needs. One reason is that the previously highly competent and well funded Swedish expert organisations within the nuclear power utilities have gradually been phased out or transformed into consulting firms. Changes have also taken place at the Swedish vendor of boiling-water plants, now Westinghouse Atom, and the activities have been down sized considerably in Sweden. There has been a similar trend in other countries. Moreover, countries which previously conducted expensive experiments have themselves increasingly sought international support as their research resources have dwindled. As a result, numerous international projects have or are planned to be started. SKI notes that Swedish nuclear activities are also becoming increasingly dependent on international collaboration. SKI further notes that in order to fulfil its assignment, the Inspectorate needs not only financial resources but also competent personnel. This enables targeted support to be maintained to strategic national infrastructure and to international cooperation including internationally financed projects. With this is meant above all experimental research where small countries such as Sweden can join forces with other countries on to important research

  5. Beyond low-level activity: On a &apos;non-radioactive&apos; gas mantle

    Energy Technology Data Exchange (ETDEWEB)

    Poljanc, Karin [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria); Steinhauser, Georg [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria)]. E-mail: georg.steinhauser@ati.ac.at; Sterba, Johannes H. [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria); Buchtela, Karl [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria); Bichler, Max [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria)

    2007-03-01

    Gas mantles for camping gas lanterns sometimes contain thorium compounds. During the last years, the use of thorium-free gas mantles has become more and more popular due to the avoidance of a radioactive heavy metal. We investigated a gas mantle type that is declared to be &apos;non-radioactive&apos; and that can be bought in Austria at the moment. Methods used were Instrumental Neutron Activation Analysis (INAA), {gamma}-spectroscopy, and Liquid Scintillation Counting (LSC). We found massive thorium contents of up to 259 mg per gas mantle. Leaching experiments showed that only 0.4% of the Th but approximately 90% of the decay products of {sup 232}Th can be leached under conditions simulating sucking and chewing with human saliva. In this paper, the investigation of these gas mantles including the consideration of the environmental hazard caused by disposed mantles and the health hazard for unsuspecting consumers is presented and legal consequences are discussed for this fraud.

  6. SAP deficiency mitigated atherosclerotic lesions in ApoE(-/-) mice.

    Science.gov (United States)

    Zheng, Lingyun; Wu, Teng; Zeng, Cuiling; Li, Xiangli; Li, Xiaoqiang; Wen, Dingwen; Ji, Tianxing; Lan, Tian; Xing, Liying; Li, Jiangchao; He, Xiaodong; Wang, Lijing

    2016-01-01

    Serum amyloid P conpoent (SAP), a member of the pentraxin family, interact with pathogens and cell debris to promote their removal by macrophages and neutrophils and is co-localized with atherosclerotic plaques in patients. However, the exact mechanism of SAP in atherogenesis is still unclear. We investigated whether SAP influence macrophage recruitment and foam cell formation and ultimately affect atherosclerotic progression. we generated apoE(-/-); SAP(-/-) (DKO) mice and fed them western diet for 4 and 8 weeks to characterize atherosclerosis development. SAP deficiency effectively reduced plaque size both in the aorta (p = 0.0006 for 4 wks; p = 0.0001 for 8 wks) and the aortic root (p = 0.0061 for 4 wks; p = 0.0079 for 8wks) compared with apoE(-/-) mice. Meanwhile, SAP deficiency inhibited oxLDL-induced foam cell formation (p = 0.0004) compared with apoE(-/-) mice and SAP treatment increases oxLDL-induced foam cell formation (p = 0.002) in RAW cells. Besides, SAP deficiency reduced macrophages recruitment (p = 0.035) in vivo and in vitro (p = 0.026). Furthermore, SAP treatment enhanced CD36 (p = 0.007) and FcγRI (p = 0.031) expression induced by oxLDL through upregulating JNK and p38 MAPK phosphorylation whereas specific JNK1/2 inhibitor reduced CD36 (p = 0.0005) and FcγRI (P = 0.0007) expression in RAW cell. SAP deficiency also significantly decreased the expression of M1 and M2 macrophage markers and inflammatory cytokines in oxLDL-induced macrophages. SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines and inhibition the CD36/FcγR-dependent signaling pathway. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. The polarized neutron reflectometer &apos;Reverans&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Radzhabov, A.K. [Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg 188300 (Russian Federation)]. E-mail: akr@pnpi.spb.ru; Gordeev, G.P. [Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg 188300 (Russian Federation); Lazebnik, I.M. [Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg 188300 (Russian Federation); Axelrod, L.A. [Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg 188300 (Russian Federation); Zabenkin, V.N. [Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg 188300 (Russian Federation)

    2007-07-15

    The polarized neutron reflectometer &apos;Reverans&apos; with a vertical plane of scattering is being installed at the VVR-M reactor (Gatchina, Russia). It will be used for research on phase boundaries, interfaces and free surfaces. Systems under study can be both magnetic and nonmagnetic ones. At present the installation of the reflectometer is at the final stage. The parameters and abilities of the reflectometer are presented.

  8. Deep-sea drilling. Practical aspects of 4D seismic: what an engineer needs to know. Developments in Iran: &apos;SIRRI&apos; of the Total company and &apos;DOROOD&apos; of the Elf company. The &apos;DOROOD&apos; operating plan. The &apos;SIRRI&apos; operating plan; Le forage en eau profonde. Aspects pratiques de la sismique 4D: ce qu&apos;un ingenieur doit savoir. Developpements en Iran: &apos;SIRRI&apos; de Total et &apos;DOROOD&apos; d&apos;Elf. Le projet &apos;DOROOD&apos;. Le projet &apos;SIRRI&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Claverie, P. [Schlumberger Sedco Forex, 92 - Montrouge (France); Bauquis, P.R. [Association Francaise des Techniciens et Professionnels du Petrole, AFTP, 92 - Paris-la-Defense (France); Seiller, B.; Geronimi, X. [Elf France, (France); Barthe, D. [Total Fina, 92 - La Defense (France)

    1999-08-01

    In this &apos;Drilling-Production&apos; section, in which 7 papers are gathered, 3 main topics are developed: (1)the deep-sea drilling (2)the practical aspects of 4D seismic (3)the &apos;SIRRI&apos; and &apos;DOROOD&apos; operating plans in Iran. Concerning the first point, it can be noticed that nowadays, mobile platforms are located in great offshore where water depths are of about 2400 m. In the second point is particularly detailed what 4D is, what it can do, what the primary conditions for it works are and how it costs. The third point is the more particularly detailed in this section (15 pages). At first an introduction indicates why Iran has to call to international petroleum investors, what the current problems of Iran are, what Iran has to do to attract foreign investment and technology and what the challenges to foreign companies are. Then the two operating plans: &apos;SIRRI&apos; and &apos;DOROOD&apos; are exposed into details. A synthesis of these plans, called of &apos;Buy Back&apos;, (production, investment, refund) is given as well as their advantages and disadvantages. (O.M.)

  9. Human Factors Engineering and Ergonomics Analysis for the Canister Storage Building (CSB) Results and Findings

    Energy Technology Data Exchange (ETDEWEB)

    GARVIN, L.J.

    1999-09-20

    The purpose for this supplemental report is to follow-up and update the information in SNF-3907, Human Factors Engineering (HFE) Analysis: Results and Findings. This supplemental report responds to applicable U.S. Department of Energy Safety Analysis Report review team comments and questions. This Human Factors Engineering and Ergonomics (HFE/Erg) analysis was conducted from April 1999 to July 1999; SNF-3907 was based on analyses accomplished in October 1998. The HFE/Erg findings presented in this report and SNF-3907, along with the results of HNF-3553, Spent Nuclear Fuel Project, Final Safety Analysis Report, Annex A, &apos;&apos;Canister Storage Building Final Safety Analysis Report,&apos;&apos; Chapter A3.0, &apos;&apos;Hazards and Accidents Analyses,&apos;&apos; provide the technical basis for preparing or updating HNF-3553. Annex A, Chaptex A13.0, &apos;'Human Factors Engineering.&apos;&apos; The findings presented in this report allow the HNF-3553 Chapter 13.0, &apos;'Human Factors,&apos;&apos; to respond fully to the HFE requirements established in DOE Order 5480.23, Nuclear Safety Analysis Reports.

  10. Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice

    DEFF Research Database (Denmark)

    Yao, Xianglan; Dai, Cuilian; Fredriksson, Karin

    2012-01-01

    Apolipoprotein E (apoE) is an endogenous negative regulator of airway hyperreactivity (AHR) and mucous cell metaplasia in experimental models of house dust mite (HDM)-induced airway disease. The gene encoding human apoE is polymorphic, with three common alleles (e2, e3, and e4) reflecting single ...

  11. Folate targeted polymeric &apos;green&apos; nanotherapy for cancer

    Energy Technology Data Exchange (ETDEWEB)

    Narayanan, Sreeja; Binulal, N S; Mony, Ullas; Manzoor, Koyakutty; Nair, Shantikumar; Menon, Deepthy, E-mail: deepthymenon@aims.amrita.edu [Amrita Center for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi-682 041, Kerala (India)

    2010-07-16

    The concept of &apos;green&apos; chemotherapy by employing targeted nanoparticle mediated delivery to enhance the efficacy of phytomedicines is reported. Poly (lactide-co-glycolide) (PLGA) nanoparticles encapsulating a well known nutraceutical namely, grape seed extract (GSE)-&apos;NanoGSE&apos;-was prepared by a nanoprecipitation technique. The drug-loaded nanoparticles of size {approx} 100 nm exhibited high colloidal stability at physiological pH. Molecular receptor targeting of this nanophytomedicine against folate receptor over-expressing cancers was demonstrated in vitro by conjugation with a potential cancer targeting ligand, folic acid (FA). Fluorescence microscopy and flow cytometry data showed highly specific cellular uptake of FA conjugated NanoGSE on folate receptor positive cancer cells. Studies were also conducted to investigate the efficiency of targeted (FA conjugated) versus non-targeted (non-FA conjugated) nanoformulations in causing cancer cell death. The IC{sub 50} values were lowered by a factor of {approx} 3 for FA-NanoGSE compared to the free drug, indicating substantially enhanced bioavailability to the tumor cells, sparing the normal ones. Receptor targeting of FA-NanoGSE resulted in a significant increase in apoptotic index, which was also quantified by flow cytometry and fluorescence microscopy. This in vitro study provides a basis for the use of nanoparticle mediated delivery of anticancer nutraceuticals to enhance bioavailability and effectively target cancer by a &apos;green&apos; approach.

  12. Accidents, &apos;Black Swans&apos; and risk

    Energy Technology Data Exchange (ETDEWEB)

    Luxat, J.C., E-mail: luxatj@mcmaster.ca [McMaster Univ., Dept. of Engineering Physics, Hamilton, Ontario (Canada)

    2013-07-01

    Major accidents and natural disasters with severe consequences have occurred in all sectors of industrial activity with relatively high frequency. The severe consequences of concern involve either significant loss of life or major economic loss, or both loss of life and economic loss. Such events have in the last two years often been referred to as &apos;Black Swan&apos; events following publication of a best-selling book. The events demonstrate limits to the application of Probabilistic Risk Assessment (PRA) that arise from the underlying unquantifiable uncertainty associated with the estimation of the frequency of occurrence of such events. An approach is proposed in this paper that, consistent with the concept of defense in depth employed by the nuclear industry, augments probabilistic risk assessment with a methodology based upon &apos;threat -risk assessment&apos;. This approach shifts these very low frequency, high uncertainty, and high consequence &apos;Black Swan&apos; events out of the probabilistic risk assessment domain and into a deterministic emergency response assessment domain. (author)

  13. Accidents, &apos;Black Swans&apos; and risk

    International Nuclear Information System (INIS)

    Luxat, J.C.

    2013-01-01

    Major accidents and natural disasters with severe consequences have occurred in all sectors of industrial activity with relatively high frequency. The severe consequences of concern involve either significant loss of life or major economic loss, or both loss of life and economic loss. Such events have in the last two years often been referred to as &apos;Black Swan&apos; events following publication of a best-selling book. The events demonstrate limits to the application of Probabilistic Risk Assessment (PRA) that arise from the underlying unquantifiable uncertainty associated with the estimation of the frequency of occurrence of such events. An approach is proposed in this paper that, consistent with the concept of defense in depth employed by the nuclear industry, augments probabilistic risk assessment with a methodology based upon &apos;threat -risk assessment&apos;. This approach shifts these very low frequency, high uncertainty, and high consequence &apos;Black Swan&apos; events out of the probabilistic risk assessment domain and into a deterministic emergency response assessment domain. (author)

  14. 7th CNS int&apos;l steam generators to controls conference - a compliment to the remarkable CNS &apos;OM+DM utility engagement initiative&apos;

    International Nuclear Information System (INIS)

    Schneider, W.

    2012-01-01

    We learned from CANDU Maintenance-Conference of December 2011, that it is our own &apos;ways-of-working&apos; as service-providers for everything from plant-architecture to operational-support, that is holding back &apos;new-build&apos; as well as &apos;re-build&apos;. CMC2011 addressed that by focusing on &apos;Needs-and-Interests of the Operating-Utilities&apos;. SGC 2012 extends that by focusing firstly on &apos;Issue-Identification&apos; to isolate &apos;items-needing-attention&apos;; then on &apos;Issue-Definition&apos; to define the &apos;work&apos; required for &apos;Issue-Resolution&apos;. It also pursues &apos;Task Leadership&apos; as a competence, essential for ... &apos;making things happen&apos;. These events and the CNS &apos;OM+DM [Operations&Maintenance and Design&Materials Divisions] Utility Engagement Initiative&apos; are seen as complimentary initiatives toward such &apos;ways-of-working-improvement&apos; objectives. (author)

  15. Les Houches &apos;&apos;Physics at TeV Colliders 2003&apos;&apos; Beyond the Standard Model Working Group: Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Allanach, B

    2004-03-01

    The work contained herein constitutes a report of the &apos;&apos;Beyond the Standard Model&apos;&apos; working group for the Workshop &apos;&apos;Physics at TeV Colliders&apos;&apos;, Les Houches, France, 26 May-6 June, 2003. The research presented is original, and was performed specifically for the workshop. Tools for calculations in the minimal supersymmetric standard model are presented, including a comparison of the dark matter relic density predicted by public codes. Reconstruction of supersymmetric particle masses at the LHC and a future linear collider facility is examined. Less orthodox supersymmetric signals such as non-pointing photons and R-parity violating signals are studied. Features of extra dimensional models are examined next, including measurement strategies for radions and Higgs&apos;, as well as the virtual effects of Kaluza Klein modes of gluons. Finally, there is an update on LHC Z&apos; studies.

  16. Computerized axial tomography of the chest for visualization of &apos;'absent'&apos; pulmonary arteries

    Energy Technology Data Exchange (ETDEWEB)

    Sondheimer, H.M. (Upstate Medical Center, Syracuse, NY); Oliphant, M.; Schneider, B.; Kavey, R.E.W.; Blackman, M.S.; Parker, F.B. Jr.

    1982-05-01

    To expand the search for central pulmonary arteries in six patients with absence of cardiac-pulmonary continuity, computerized axial tomography (CAT) of the chest was performed. The CAT scans were compared with previous arteriograms and pulmonary vein wedge angiograms. Three patients with type IV truncus arteriosus were studied, and none had a central, right or left pulmonary artery on CAT scan. However, two patients with tetralogy of Fallot with pulmonary atresia and a patent ductus arteriosus to the right lung demonstrated the presence of a left pulmonary artery. In addition, one child with truncus arteriosus with &apos;'absent'&apos; left pulmonary artery demonstrated a left pulmonary artery on the CAT scan. The CAT scan may therefore enhance our ability to search for disconnected pulmonary arteries in children with complex cyanotic congenital heart disease.

  17. Aharonov-Bohm effect for a fermion field in a planar black hole &apos;'spacetime'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anacleto, M.A.; Mohammadi, A. [Universidade Federal de Campina Grande, Departamento de Fisica, Caixa Postal 10071, Campina Grande, Paraiba (Brazil); Brito, F.A. [Universidade Federal de Campina Grande, Departamento de Fisica, Caixa Postal 10071, Campina Grande, Paraiba (Brazil); Universidade Federal da Paraiba, Departamento de Fisica, Caixa Postal 5008, Joao Pessoa, Paraiba (Brazil); Passos, E. [Universidade Federal de Campina Grande, Departamento de Fisica, Caixa Postal 10071, Campina Grande, Paraiba (Brazil); Universidade Federal do Rio de Janeiro, Instituto de Fisica, Caixa Postal 21945, Rio de Janeiro (Brazil)

    2017-04-15

    In this paper we consider the dynamics of a massive spinor field in the background of the acoustic black hole spacetime. Although this effective metric is acoustic and describes the propagation of sound waves, it can be considered as a toy model for the gravitational black hole. In this manner, we study the properties of the dynamics of the fermion field in this &apos;'gravitational'&apos; rotating black hole as well as the vortex background. We compute the differential cross section through the use of the partial wave approach and show that an effect similar to the gravitational Aharonov-Bohm effect occurs for the massive fermion field moving in this effective metric. We discuss the limiting cases and compare the results with the massless scalar field case. (orig.)

  18. Prospects for neutron star equation of state constraints using &apos;'recycled'&apos; millisecond pulsars

    Energy Technology Data Exchange (ETDEWEB)

    Bogdanov, Slavko [Columbia University, Columbia Astrophysics Laboratory, New York, NY (United States)

    2016-02-15

    &apos;'Recycled'&apos; millisecond pulsars are a variety of rapidly spinning neutron stars that typically show thermal X-ray radiation due to the heated surface of their magnetic polar caps. Detailed numerical modeling of the rotation-induced thermal X-ray pulsations observed from recycled millisecond pulsars, including all relevant relativistic and stellar atmospheric effects, has been identified as a promising approach towards an astrophysical determination of the true neutron star mass-radius relation, and by extension the state of cold matter at densities exceeding those of atomic nuclei. Herein, I review the basic model and methodology commonly used to extract information regarding neutron star structure from the pulsed X-ray radiation observed from millisecond pulsars. I also summarize the results of past X-ray observations of these objects and the prospects for precision neutron star mass-radius measurements with the upcoming Neutron Star Interior Composition Explorer (NICER) X-ray timing mission. (orig.)

  19. The &apos;Transnuklear affair&apos; and its consequences. Die &apos;Transnuklear-Affaere&apos; und ihre Auswirkungen

    Energy Technology Data Exchange (ETDEWEB)

    Brinkert, M.

    1992-03-01

    The &apos;Bribe&apos; and &apos;Drum&apos; Affairs and suspected proliferation in connection with Transnuklear GmbH public around the turn of 1987/88. Many members of the press wished them to speed up the process of opting out of nuclear power. However, none of the accusations specifically related to nuclear power leveled at that time turned out to be tenable. Instead, all violations of the law which had been detected could have been punished in the same way as in any other branch of industry. As a consequence, the impacts arising to regulatory structures in the nuclear sector, especially the measures taken by the Federal Government, may be considered to have been unjustified in scope. The TN Affair and the associated litigation has caused a great deal of confidence in nuclear power to be lost, which now has to be reclaimed by purposeful public relations efforts. (orig.).

  20. &apos;Bluetooth&apos; for radio-connecting short distance; Kinkyori wo musen setsuzokusuru &apos;Bluetooth&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    &apos;Bluetooth&apos; is a new connection method for radio-connecting a short distance by means of mobile equipment including a note PC, PC peripheral equipment and portable telephone, using 2.4GHz ISM (Industrial Scientific Medical) band. It is capable of making a network without a complex operation, enabling data and audio communications. In May, 1998, an operation for deciding on the specifications was started under the leadership of five companies consisting of Ericsson, Nokia, Intel, IBM and Toshiba, with the specification version 1.0 completed in July, 1999 and opened to the public. (readable on http://www.bluetooth.com). Using such features as low power consumption, low cost and small size, the &apos;Bluetooth&apos; will be mounted on various kinds of mobile equipment and developed in mobile PAN (Personal Area Network). (translated by NEDO)

  1. Hawai&apos;i&apos;s EVolution: Hawai&apos;i Powered. Technology Driven. (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2013-05-01

    This Hawaii Clean Energy Initiative (HCEI) brochure outlines Hawaii&apos;s energy and transportation goals and the implementation of electric vehicles (EV) and electric vehicle infrastructure since HCEI began in 2008. It includes information about Hawaii&apos;s role in leading the nation in available EV charging infrastructure per capita; challenges for continuing to implement EV technology; features on various successful EV users, including the Hawaiian Electric Company, Enterprise Rent-A-Car, and Senator Mike Gabbard; how EVs can integrate into and help propel Hawaii&apos;s evolving smart grid; and much more.

  2. Why Germany&apos;s &apos;Messy&apos; energy transition should be a lesson to other nations

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Brighton (United Kingdom)

    2015-03-15

    Germany&apos;s so-called &apos;&apos;energy transition&apos;&apos; (&apos;'Energiewende'&apos;) is increasingly drawing the intention of the international community - but it seems for all the wrong reasons. US Senator Lamar Alexander said recently that German energy policy is one of the reasons the US should not abandon nuclear, but actually encourage increased investment in nuclear power plants. Alexander&apos;s remarks were made in an article published by the US Nuclear Energy Institute, in which he outlined his reasons why the US should not follow Germany&apos;s lead. Alexander rightly pointed out that the cost of attempting to replace nuclear power with wind, solar, and accompanying infrastructure is estimated by the German government at some 1.2 trillion US dollars (about 1 trillion Euros). The senator also made the point that Germany &apos;&apos;does not produce enough reliable, baseload energy for an important manufacturing economy&apos;&apos;. He also expressed concern at Germany&apos;s reliance on buying natural gas from Russia. While Germany has been forcing the closure of nuclear power plants others, including the oil-rich United Arab Emirates (UAE), have been investing in new nuclear, Alexander said. Judging from Alexander&apos;s remarks, it seems that Germany&apos;s energy transition experience will, after all, have a long-lasting legacy. That legacy will be a valuable lesson to other major industrialised nations in why they should not follow Germany&apos;s lead in abandoning a sensible energy mix, if they wish to maintain and develop economic and industrial productivity while keeping to international commitments to tackle climate change.

  3. BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet

    OpenAIRE

    Williams, Jarrod; Ensor, Charles; Gardner, Scott; Smith, Rebecca; Lodder, Robert

    2015-01-01

    Objective This study tests the hypothesis that BSN723T can prevent the development of hyperlipidemia and atherosclerosis in ApoE-/- knockout mice fed a Western (high fat, high cholesterol, and high sucrose) diet. BSN723T is a combination drug therapy consisting of D-tagatose and dihydromyricetin (BSN723). Background D-tagatose has an antihyperglycemic effect in animal and human studies and shows promise as a treatment for type 2 diabetes and obesity. Many claims regarding BSN723's pharmacolog...

  4. Iran&apos;s &apos;Risk-Taking&apos; in Perspective

    Energy Technology Data Exchange (ETDEWEB)

    Shahram, Chubin

    2008-07-01

    Assessing any state&apos;s intentions is a difficult undertaking - especially at a specific moment in time. When a state is considered hostile, its behaviour erratic, and its system opaque, what is difficult under normal circumstances becomes nearly impossible. It may thus often seem prudent to attribute the worst of intentions to such states, but this can create a self-fulfilling prophecy. Iran with its revolutionary pretensions, fiery rhetoric and nuclear ambitions, is a case in point, since it is particularly difficult to &apos;read&apos;. Located in the centre of a geo-politically sensitive and conflict-driven area, Iran is in a position to influence - positively or otherwise - the Persian Gulf, the Caucasus, the Middle East and South Asia. This influence may furthermore be expanding as a result of the weakening of Iraq and Lebanon, divisions among the Palestinians, and the more general rise of the Shi&apos;i across the broader region. Add to this the ambiguous aims of Iran&apos;s nuclear programme and the shadow this has already thrown across the region, and the need to assess Iran&apos;s intentions accurately appears crucial. Here, Iran&apos;s past behavior may provide some help, especially when it comes to Iran&apos;s proclivity for risk taking - provided the acquisition of a nuclear capability does not alter Iran&apos;s intentions or behavior so as to make the past irrelevant. Some commentators believe that Iran&apos;s ideology and past behaviour suggest that a nuclear-capable Iran will be inclined to take on a high level of risk, without concern for the potential costs of this recklessness, and that Iran may perhaps even welcome the risks involved. By contrast, the recent National Intelligence Estimate (NIE), a composite of US intelligence agency estimates, has concluded that Iran&apos;s &apos;decisions are guided by a cost-benefit approach&apos; and therefore &apos;may be more vulnerable to influence&apos; than they had previously (i.e.2005) judged. These

  5. Development of a research prototype computer &apos;Wearables&apos; that one can wear on his or her body. Minitsukeru computer &apos;Wearables&apos; kenkyuyo shisakuki wo kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    1999-02-01

    Development has been made on a prototype of a wearable computer &apos;Wearables&apos; that makes the present notebook type PC still smaller in size, can be worn on human body for utilization at any time and from anywhere, and aims at realizing a social infrastructure. Using the company&apos;s portable PC, Libretto as the base, the keyboard and the liquid crystal display panel were removed. To replace these functions, a voice inputting microphone, and various types of head mounting type displays (glasses type) mounted on a head to see images are connected. Provided as the means for information communication between the prototype computer and outside environments are infrared ray interface and data communication function using wireless (electric wave) communications. The wireless desk area network (DAN) technology that can structure dynamically a network between multiple number of computers has realized smooth communications with external environments. The voice recognition technology that can work efficiently against noise has realized keyboard-free operation that gives no neural stress to users. The &apos;wearable computer&apos; aims at not only users utilizing it simply wearing it, but also providing a new perception ability that could not have been seen or heard directly to date, that is realizing the digital sensation. With the computer, a society will be structured in which people can live comfortably and safely, maintaining conversations between the users and the computers, and interactions between the surrounding environment and the social infrastructures, with protection of individual privacy and information security taken into consideration. The company is working with the Massachusetts Institute of Technology (MIT) for research and development of the &apos;wearable computer&apos; as to how it can be utilized and basic technologies that will be required in the future. (translated by NEDO)

  6. The United States and international climate cooperation: International &apos;pull&apos; versus domestic &apos;push&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bang, Guri [Center for International Climate and Environmental Research, Oslo (Norway); Froyn, Camilla Bretteville [Center for International Climate and Environmental Research, Oslo (Norway); Hovi, Jon [Center for International Climate and Environmental Research, Oslo (Norway) and Department of Political Science, University of Oslo, P.O. Box 1097, 0317 Oslo (Norway)]. E-mail: jon.hovi@stv.uio.no; Menz, Fredric C. [Center for International Climate and Environmental Research, Oslo (Norway); School of Business, Clarkson University, Potsdam, NY 13699 (United States)

    2007-02-15

    The US government is being pressured by both international and domestic influences to re-engage in international climate control. This paper considers whether the international &apos;pull&apos; and the domestic &apos;push&apos; will be strong enough to accomplish this. First, we discuss whether changes in the architecture of the current climate regime might induce the United States to re-engage at the international level. We argue that the United States is unlikely to rejoin any global climate regime that is based on the Kyoto architecture, even if Kyoto were to be &apos;reformed&apos;. Second, we discuss whether domestic political developments might eventually cause the United States to re-engage. We conclude that US re-engagement is likely to require the emergence of a new climate regime that basically extends US regulation to other countries. However, the forging of a unified US climate policy is still in the making. Furthermore, a new regime can gain widespread participation only if the Kyoto countries accept the idea of replacing Kyoto with some alternative architecture, which seems unlikely in the near future.

  7. In-vitro analysis of the dissolution kinetics and systemic availability of plutonium ingested in the form of &apos;hot&apos; particles from the Semipalatinsk NTS

    Energy Technology Data Exchange (ETDEWEB)

    Conway, M. [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Leon Vintro, L. [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland)], E-mail: luis.leon@ucd.ie; Mitchell, P.I. [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Garcia-Tenorio, R.; Jimenez-Ramos, M.C. [Departamento de Fisica, Universidad de Sevilla, 41012 Sevilla (Spain); Burkitbayev, M. [Department of Inorganic Chemistry, Al-Farabi Kazakh National University, Almaty (Kazakhstan); Priest, N.D. [School of Health and Social Sciences, Middlesex University, Queensway, Enfield EN3 4SA (United Kingdom)

    2009-05-15

    In-vitro leaching of radioactive &apos;hot&apos; particles isolated from soils sampled at the Semipalatinsk Nuclear Test Site has been carried out in order to evaluate the fraction of plutonium activity released into simulated human stomach and small intestine fluids during digestion. Characterisation of the particles (10-100 Bq {sup 239,240}Pu) and investigation of their dissolution kinetics in simulated fluids has been accomplished using a combination of high-resolution alpha-spectrometry, gamma-spectrometry and liquid scintillation counting. The results of these analyses indicate that plutonium transfer across the human gut following the ingestion of &apos;hot&apos; particles can be up to two orders of magnitude lower than that expected for plutonium in a more soluble form, and show that for areas affected by local fallout, use of published ingestion dose coefficients, together with bulk radionuclide concentrations in soil, may lead to a considerable overestimation of systemic uptake via the ingestion pathway.

  8. Exercise training and antioxidant supplementation independently improve cognitive function in adult male and female GFAP-APOE mice

    OpenAIRE

    Kiran Chaudhari; Jessica M. Wong; Philip H. Vann; Nathalie Sumien

    2014-01-01

    Purpose: The purpose of this study was to determine if antioxidant supplementation, moderate exercise, and the combination of both treatments could ameliorate cognitive performance in adult mice and whether the apolipoprotein E (APOE) genotype as well as sex could influence the functional outcomes of the treatments. Methods: For a period of 16 weeks, separate groups of male and female mice expressing either the human APOE3 or APOE4 isoforms were fed either a control diet (NIH-31) or the co...

  9. Hybrid coolers allow important water saving; Les refroidisseurs &apos;'hybrides'&apos; permettent des economies d&apos;eau importantes

    Energy Technology Data Exchange (ETDEWEB)

    Bitsch, V. [Societe Jaeggi-France (France)

    2005-03-01

    Air cooling systems used with refrigerating machineries are in general highly water and electricity consuming. The use of &apos;hybrid&apos; systems having the characteristics of both close-cycle evaporative systems and dry coolers allow important water saving. This article presents the operation principle and characteristics of such cooling systems. (J.S.)

  10. Calogero&apos;s &apos;goldfish&apos; is indeed a school of free particles

    Energy Technology Data Exchange (ETDEWEB)

    Nucci, M C [Dipartimento di Matematica e Informatica, Universita di Perugia, 06123 Perugia (Italy)

    2004-11-26

    A many-body system of N nonlinear ordinary differential equations of second order which is amenable to exact treatments (a &apos;goldfish&apos;) (Calogero 2001 The neatest many-body problem amenable to exact treatments (a &apos;goldfish&apos;?) Physica D 152-153 78-84) is shown to be equivalent through an exact transformation to the equations of one-dimensional motion of (N-1) free particles (a school of free particles, indeed). The transformation is obtained by applying the reduction method and Lie group analysis as introduced in Nucci (1996 The complete Kepler group can be derived by Lie group analysis J. Math. Phys. 37 1772-5)

  11. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

    Directory of Open Access Journals (Sweden)

    Benfeard Williams

    2015-10-01

    Full Text Available The increased risk of developing Alzheimer's disease (AD is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 and ApoE2 are considered to be the AD-neutral and AD-protective isoforms, respectively. It has been hypothesized that the ApoE isoforms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partners and AD-related proteins in an isoform-specific fashion. Here we find that, despite the high sequence similarity among the three ApoE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific domain-domain interactions in molecular dynamics simulations. The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-dependent lipid transport efficiency or in AD-related protein aggregation and clearance. We present what we believe to be the first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the molecular mechanism underlying the role of ApoE4 in AD pathogenesis. The knowledge of the structure for the ApoE4 folding intermediate provides a new platform for the rational design of alternative therapeutic strategies to fight AD.

  12. A highly luminescent dinuclear Eu(III) complex based on 4,4&apos;-bis (4&apos;&apos;,4&apos;&apos;,4&apos;&apos;-trifluoro-1&apos;&apos;,3&apos;&apos;-dioxobutyl)-o-terphenyl for light-emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Liu Shenggui [State Key Laboratory of Optoelectronic Materials and Technologies, Ministry of Education Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China); School of Chemistry Science and Technology, Zhanjiang Normal University, New Materials Engineering and Technology Development Center of University in Guangdong, Zhanjiang 524048 (China); He Pei; Wang Huihui; Shi Jianxin [State Key Laboratory of Optoelectronic Materials and Technologies, Ministry of Education Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China); Gong Menglian, E-mail: cesgml@mail.sysu.edu.cn [State Key Laboratory of Optoelectronic Materials and Technologies, Ministry of Education Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China)

    2009-08-15

    A dinuclear Eu(III) complex Eu{sub 2}(btbt){sub 3}.4H{sub 2}O.CH{sub 3}CH{sub 2}OH.N(CH{sub 2}CH{sub 3}){sub 3} was synthesized, where H{sub 2}(btbt) was 4,4&apos;-bis (4&apos;&apos;,4&apos;&apos;,4&apos;&apos;,-trifluoro-1&apos;&apos;,3&apos;&apos;-dioxobutyl)-o-terphenyl. The composition and structure of the complex were characterized by elemental analysis, IR, UV-vis and FAB-MS spectroscopy. The complex emits the characteristic red luminescence of Eu{sup 3+} ion due to the {sup 5}D{sub 0} {yields} {sup 7}F{sub J} (J = 0-4) transitions under {approx}395 nm-light excitation with good luminescent quantum efficiency (32%) and exhibits high thermal stability (337 deg. C). Bright red light-emitting diodes (LEDs) were fabricated by coating the complex onto a {approx}395 nm-emitting InGaN chip. When the mass ratio of the red phosphor to the silicone is 1:30, the efficiency of the fabricated LEDs with the europium complex is 0.98 lm w{sup -1}. The CIE chromaticity coordinates of the LEDs are x = 0.6057 and y = 0.3137, which are close to the National Television Standard Committee (NTSC) standard values for red color. The results indicate that the complex may act as a red component in the fabrication of near UV InGaN-based white light-emitting diodes with high color-rendering index.

  13. Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments

    Directory of Open Access Journals (Sweden)

    Chou Chi-Yuan

    2011-01-01

    Full Text Available Abstract Backgrounds There are three apolipoprotein E (apoE isoforms involved in human lipid homeostasis. In the present study, truncated apoE2-, apoE3- and apoE4-(72-166 peptides that are tailored to lack domain interactions are expressed and elucidated the structural and functional consequences. Methods & Results Circular dichroism analyses indicated that their secondary structure is still well organized. Analytical ultracentrifugation analyses demonstrated that apoE-(72-166 produces more complicated species in PBS. All three isoforms were significantly dissociated in the presence of dihexanoylphosphatidylcholine. Dimyristoylphosphatidylcholine turbidity clearance assay showed that apoE4-(72-166 maintains the highest lipid-binding capacity. Finally, only apoE4-(72-166 still maintained significant LDL receptor binding ability. Conclusions Overall, apoE4-(72-166 peptides displayed a higher lipid-binding and comparable receptor-binding ability as to full-length apoE. These findings provide the explanation of diverged functionality of truncated apoE isoforms.

  14. FY 1999 New Sunshine Project survey research project - Survey on the long-term energy technology strategy, etc. Fundamental survey to decide on the industrial technology strategy - Technology strategy by field (Electronic information technology field - Human process ware technology field of the computer relation field); 1999 nendo choki energy gijutsu senryaku nado ni kansuru chosa hokokusho. Sangyo gijutsu senryaku sakutei kiban chosa (bun&apos;yabetsu gijutsu senryaku (denshi joho gijutsu bun&apos;ya (computer kanren bun&apos;ya no uchi, human process ware gijutsu bun&apos;ya)))

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The survey/study were conducted to contribute to proposing technology strategies such as the analysis of the present state of technical competitive force and the forecast in the human process ware industry technology field of the computer relation field. The human process ware is a system aimed at fermenting human power for thinking, problem solution and creation. Its main subjects are the following three: close society technology for will communication by automatically learning backgrounds of people joining the community; topics community technology for community formation for the appropriate people/organizations by grasping true topics/purposes from conversation; active interaction technology for supporting creative activities of users/community and making conversation with users. Further, in the region of the technology to meet the requests/restrictions from the society, the following are expected: energy/resource conservation; realization of the life with ease/safety and of high quality in the aged society; realization of the advanced information network society which becomes the basis of a new economic society. (NEDO)

  15. Design of the fuel element &apos;snow-flake&apos; in uranium oxide, canned with aluminium, for the experimental reactor EL 3 (1960); Etude d&apos;un element combustible en oxyde d&apos;uranium gaine d&apos;aluminium, type &apos;&apos;cristal de neige&apos;&apos; pour la pile EL 3 (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Gauthron, M.; Guibert, B. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    This report sums up the main studies have been carried out on the fuel element &apos;Snowflake&apos; (uranium oxide, canned with aluminium), designed to replace the present element of the experimental reactor EL3 in order to increase the reactivity without modifying the neutron flux/thermal power ratio. (author) [French] Ce rapport resume les principales etudes qui ont ete faites sur l&apos;element combustible &apos;Cristal de Neige&apos; (a oxyde d&apos;uranium, gaine d&apos;aluminium) destine a remnlacer l&apos;element actuel du reacteur experimental EL3, afin d&apos;en augmenter la reactivite sans modifier le rapport flux neutronique-puissance thermique. (auteur)

  16. A &apos;must-go path&apos; scenario for sustainable development and the role of nuclear energy in the 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Hae-Yong; Kim, Young-In; Lee, Yong-Bum; Ha, Kwi-Seok; Won, Byung-Chool; Lee, Dong-Uk; Hahn, Dohee [Korea Atomic Energy Research Institute, 1045 Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea)

    2010-04-15

    An increase in the world population has accelerated the consumption of fossil fuels and deepened the pollution of global environment. As a result of these human activities, it is now difficult to clearly guarantee the sustainable future of humankind. An intuitional &apos;must-go path&apos; scenario for the sustainable development of human civilization is proposed by extrapolating the human historical data over 30 years between 1970 and 2000. One of the most important parameters in order to realize the &apos;must-go path&apos; scenario is the sustainability of energy without further pollution. In some countries an expanded use of nuclear energy is advantageous to increase sustainability, but fast reactor technology and closed fuel cycle have to be introduced to make it sustainable. In other countries, the development of cost-effective renewable energy, and the clean use of coal and oil are urgently needed to reduce pollution. The effect of fast nuclear reactor technology on sustainability as an option for near-term energy source is detailed in this paper. More cooperation between countries and worldwide collaboration coordinated by international organizations are essential to make the &apos;must-go path&apos; scenario real in the upcoming 20 or 30 years. (author)

  17. Optimisation of biological reactors using the &apos;biological resonance&apos; phenomenon; Ansatz zur Optimierung biologischer Reinigungsstufen durch das Phaenomen der &apos;&apos;Biologischen Resonanz&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, A.

    2003-07-01

    The microbial catabolic activity of biological reactors can be increased by up to 75% through external stimulation with intermittent stress loads at intervals of several minutes. Under these process conditions, the &apos;&apos;biological resonance&apos;&apos; phenomenon determines the system and leads to an increased synthesis of enzymes. In addition to computer simulations, experiments with activated sludge were carried out in a 10-litre bioreactor. By modulating the stress intervals, a permanent increase in catabolic activity of about 60% was achieved during these experiments. By relying on the &apos;&apos;biological resonance&apos;&apos; phenomenon, the required reaction volume of biological treatment units can probably be reduced by up to 40%. (orig.)

  18. The Novel SCN&apos;&apos;- Ion-selective Electrode Based on the 1-Benzyl-3-(4-nitrophenyl) thio-urea Ionophore

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Mi; Kang, Dong Hyeon; Choe, Ju Eun; You, Jung Min; Go, Min Jeong; Lee, Jung Seong; Jeon, Seung Won [Chungnam National University, Daejeon (Korea, Republic of)

    2014-09-15

    A potentiometric sensor based on the 1-benzyl-3-(4-nitrophenyl) thio-urea was synthesized and tested as an ionophore in PVC based membrane sensor towards SCN - ions. This membrane exhibits a linear stable response over a wide concentration range (1.0 × 10&apos;&apos;-5 to 1.0 × 10&apos;&apos;-2 M) with a slope of -59.2 mV/dec., a detection limit of log[SCN&apos;&apos;- ] = -5.05, and a selectivity coefficient for thiocyanate against perchlorate anion of logK{sub s}cn&apos;&apos;pot = -0.133. The selectivity series of the membrane is as follows: SCN&apos;&apos;- > ClO{sub 4}&apos;&apos;- > I&apos;&apos;- >NO{sub 3}&apos;&apos;- >HSO{sub 3}&apos;&apos;- > Cl&apos;&apos;-HSO{sub &apos;}'-'&apos;4 > F&apos;&apos;- > CH{sub 3}COO&apos;&apos;- > HCO&apos;'-'&apos;3 > Br&apos;&apos;- > H{sub 2}PO{sub 4}&apos;&apos;- > SO{sub 3}&apos;'-'&apos;2 > SO{sub 4}&apos;'-'&apos;2 > CO{sub 3}&apos;'-'&apos;2. The proposed electrode showed good selectivity and a good response for the SCN&apos;&apos;- ion over a wide variety of other anions in pH 6.0 buffer solutions and has a fast response time of about < 5s.. The influences of the membrane by pH, ionophore, and plasticizer were studied.

  19. Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice.

    Directory of Open Access Journals (Sweden)

    Pin Yue

    2010-03-01

    Full Text Available CD36 facilitates oxidized low density lipoprotein uptake and is implicated in development of atherosclerotic lesions. CD36 also binds unmodified high and very low density lipoproteins (HDL, VLDL but its role in the metabolism of these particles is unclear. Several polymorphisms in the CD36 gene were recently shown to associate with serum HDL cholesterol. To gain insight into potential mechanisms for these associations we examined HDL metabolism in CD36 null (CD36(-/- mice. Feeding CD36(-/- mice a high cholesterol diet significantly increased serum HDL, cholesterol and phospholipids, as compared to wild type mice. HDL apolipoproteins apoA-I and apoA-IV were increased and shifted to higher density HDL fractions suggesting altered particle maturation. Clearance of dual-labeled HDL was unchanged in CD36(-/- mice and cholesterol uptake from HDL or LDL by isolated CD36(-/- hepatocytes was unaltered. However, CD36(-/- hepatocytes had higher cholesterol and phospholipid efflux rates. In addition, expression and secretion of apoA-I and apoA-IV were increased reflecting enhanced PXR. Similar to hepatocytes, cholesterol and phospholipid efflux were enhanced in CD36(-/- macrophages without changes in protein levels of ABCA1, ABCG1 or SR-B1. However, biotinylation assays showed increased surface ABCA1 localization in CD36(-/- cells. In conclusion, CD36 influences reverse cholesterol transport and hepatic ApoA-I production. Both pathways are enhanced in CD36 deficiency, increasing HDL concentrations, which suggests the potential benefit of CD36 inhibition.

  20. Air cooling of refrigerating loops: &apos;dry-hybrid&apos; systems; Refroidissement par air des circuits frigorifiques: les systemes &apos;&apos;secs hybrides&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Becker, W. [Societe Jaggi-Gunter (Switzerland)

    2003-02-01

    Different type of cooling systems can be implemented on coldness production plants. The choice very often depends on the initial investment, but from a technical and economical point of view, this choice is not necessary the best solution. Thus, it can be useful to know the different existing systems and their exploitation costs with respect to the expected needs. A particular solution which uses a &apos;dry-hybrid&apos; cooler is presented in this study: 1 - open-loop evaporative cooler; 2 - open-loop evaporative cooler with intermediate exchanger; 3 - close-loop evaporative cooler; 4 - dry-cooler; 5 - dry cooler with spraying in the air flow way; 6 - dry cooler with counterflow spraying; 7 - hybrid dry cooler; 8 - example of a realization in Germany: technical and economical value of the project, description of compared solutions and hypotheses, interpretation of results. (J.S.)

  1. Cuts in energy and operating cost with the Swiss system &apos;Energie in ARA&apos; - practical experience in Germany; Energie- und Betriebskosteneinsparungen nach dem schweizerischen System &apos;&apos;Energie in ARA&apos;&apos; - Praxiserfahrungen in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Christmann, B. [UmBAUwelt Partnerschaft Architekten und Ingenieure, Riedstadt (Germany)

    1999-07-01

    German sewage treatment plants, too, have potential for saving energy cost and cutting down on their operating expenditure. Following the systematy developed by the &apos;Energie in ARA&apos; concept, this potential can be harnessed. (orig.) [German] Potential fuer Energiekosteneinsparungen und dadurch initiierte Betriebskosteneinsparungen ist auch bei deutschen Klaeranlagen vorhanden. Die Systematik &apos;Energie in ARA&apos; kann fuer die Erschliessung der Einsparpotentiale verwendet werden. (orig.)

  2. 2001-2003 &apos;&apos;public utility&apos;&apos; contract between the French government and Gaz de France; Contrat de &apos;&apos;service public&apos;&apos; 2001-2003 entre l&apos;etat et Gaz de France

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The &apos;&apos;public utility&apos;&apos; contract aims at specifying the actions of Gaz de France (GdF), the French gas utility, in terms of national development and public utility presence at the local scale. It extends and completes the &apos;contract of group&apos; established between the government and GdF in the domain of quality of the services offered to clients, development of gas infrastructures and extension of gas supplies, and sustainable development. (J.S.)

  3. Trainees&apos; Perceived Knowledge Gain Unrelated to the Training Domain: The Joint Action of Impression Management and Motives

    Science.gov (United States)

    Chiaburu, Dan S.; Huang, Jason L.; Hutchins, Holly M.; Gardner, Richard G.

    2014-01-01

    Trainees&apos; knowledge gains represent an important outcome in human resource development. In this research, we tested a model examining the joint influence of social desirability (impression management, self-deception) and motives (need for power, need for approval) on trainees&apos; self-reported knowledge gain. We conducted a study with…

  4. John Dewey&apos;s Dual Theory of Inquiry and Its Value for the Creation of an Alternative Curriculum

    Science.gov (United States)

    Harris, Fred

    2014-01-01

    Dewey&apos;s theory of inquiry cannot be reduced to the pattern of inquiry common to both common-sense inquiry and scientific inquiry, which is grounded in the human life process, since such a reduction ignores Dewey&apos;s differentiation of the two forms of inquiry. The difference has to do with the focus of inquiry, with common-sense inquiry…

  5. &apos;Biomoleculas&apos;: cellular metabolism didactic software

    Energy Technology Data Exchange (ETDEWEB)

    Menghi, M L [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina); Novella, L P [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina); Siebenlist, M R [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina)

    2007-11-15

    &apos;Biomoleculas&apos; is a software that deals with topics such as the digestion, cellular metabolism and excretion of nutrients. It is a pleasant, simple and didactic guide, made by and for students. In this program, each biomolecule (carbohydrates, lipids and proteins) is accompanied until its degradation and assimilation by crossing and interrelating the different metabolic channels to finally show the destination of the different metabolites formed and the way in which these are excreted. It is used at present as a teaching-learning process tool by the chair of Physiology and Biophysics at the Facultad de Ingenieria - Universidad Nacional de Entre Rios.

  6. An exercise in &apos;anhomomorphic logic&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Sorkin, Rafael D [Perimeter Institute, 31 Caroline Street North, Waterloo ON, N2L 2Y5 (Canada); Department of Physics, Syracuse University, Syracuse, NY 13244-1130 (United States)

    2007-05-15

    A classical logic exhibits a threefold inner structure comprising an algebra of propositions U, a space of &apos;truth values&apos; V, and a distinguished family of mappings {phi} from propositions to truth values. Classically U is a Boolean algebra, V = Z{sub 2}, and the admissible maps {phi}: U Z{sub 2} are homomorphisms. If one admits a larger set of maps, one obtains an anhomomorphic logic that seems better suited to quantal reality (and the needs of quantum gravity). I explain these ideas and illustrate them with three simple examples.

  7. &apos;&apos;Rio+20 on site&apos;&apos;. Communities on their way to sustainability. Examples from Germany; &apos;&apos;Rio+20 vor Ort&apos;&apos;. Kommunen auf dem Weg zur Nachhaltigkeit. Beispiele aus Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Nolting, Katrin; Goell, Edgar

    2012-03-15

    20 years ago, the international community adopted the concept of &apos;sustainable development&apos; as a model for the 21st century adopted in order to meet the growing challenges facing the mankind. With Agenda 21, the UN presented a global action plan for the implementation of such a sustainable development. This brochure provides an insight into sustainability activities at local level in Germany. It is shown how such activities result in future-oriented and exemplary developments in some areas and selected areas of action.

  8. Intelligent marketing of electricity from decentral power sources. Project results of the research project &apos;'Massig'&apos;; Intelligente Vermarktung von Strom aus dezentralen Energiequellen. Projektergebnisse des Forschungsvorhabens &apos;'Massig'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Erge, Thomas; Sauer, Christian [Fraunhofer-Institut fuer Solare Energiesysteme ISE, Freiburg (Germany); Barnsteiner, Martin; Preiser, Klaus [Badenova Waermeplus GmbH und Co.KG, Freiburg (Germany)

    2011-07-01

    In the European research project &apos;Market Access for Smaller Size Intelligent Electricity Generation (Massig)&apos; scientists at the Fraunhofer Institute for Solar Energy Systems (Freiburg, Federal Republic of Germany) examined together with project partners the demand-oriented supply and commercialization of electricity from decentral power generators at the liberalized electricity market. The project team selected target countries and evaluated innovative solutions of marketing especially for specific applications of practice. Such a model project is that of Badenova Waermeplus GmbH (Freiburg, Federal Republic of Germany).

  9. Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteins

    Directory of Open Access Journals (Sweden)

    Sahasrabudhe Sudhir

    2008-10-01

    Full Text Available Abstract Background In order to establish a successful infection in the human host, the malaria parasite Plasmodium falciparum must establish interactions with a variety of human proteins on the surface of different cell types, as well as with proteins inside the host cells. To better understand this aspect of malaria pathogenesis, a study was conducted with the goal of identifying interactions between proteins of the parasite and those of its human host. Methods A modified yeast two-hybrid methodology that preferentially selects protein fragments that can be expressed in yeast was used to conduct high-throughput screens with P. falciparum protein fragments against human liver and cerebellum libraries. The resulting dataset was analyzed to exclude interactions that are not likely to occur in the human host during infection. Results An initial set of 2,200 interactions was curated to remove proteins that are unlikely to play a role in pathogenesis based on their annotation or localization, and proteins that behave promiscuously in the two-hybrid assay, resulting in a final dataset of 456 interactions. A cluster that implicates binding between P. falciparum PFE1590w/ETRAMP5, a putative parasitophorous vacuole membrane protein, and human apolipoproteins ApoA, ApoB and ApoE was selected for further analysis. Different isoforms of ApoE, which are associated with different outcomes of malaria infection, were shown to display differential interactions with PFE1590w. Conclusion A dataset of interactions between proteins of P. falciparum and those of its human host was generated. The preferential interaction of the P. falciparum PFE1590w protein with the human ApoE ε3 and ApoE ε4 isoforms, but not the ApoE ε2 isoform, supports the hypothesis that ApoE genotype affects risk of malaria infection. The dataset contains other interactions of potential relevance to disease that may identify possible vaccine candidates and drug targets.

  10. Crisis - Weisskopf&apos;s view

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    &apos;We are facing a crisis, not only in particle physics but in the whole of fundamental science&apos;, said Victor Weisskopf, doyen of quantum physics, during his traditional summer CERN stopover. &apos;Basic science - science for its own sake - and especially high energy physics, is really in danger.&apos; As well as explaining how this has come about, the former CERN Director General (1961-5) proposed action to reverse the trend. Rather than dividing science into the conventional &apos;big&apos; and &apos;small&apos; camps, he slices across another axis. On one hand there is obviously applicable &apos;terrestrial science&apos; - biology, medicine, solid state, much of the nuclear sector, nonlinear behaviour, chaos,....all directly connected with processes that happen on Earth. On the other there is &apos;cosmic science&apos; - astronomy, astrophysics, particle physics and some of the nuclear sector - addressing deeper issues, not attainable naturally on this planet at all, and where applications are less immediately obvious. (This classification is not completely watertight - even cosmic science can, and does, foster immediate spinoff, Weisskopf points out, citing Georges Charpak&apos;s detector work.) Tracing the evolution of science in this century, Weisskopf sees the rapid evolution of American influence in the 1930s as a turning point. Before then, the United States had not been in the front line, and it had been important for US researchers to spend some time in Europe

  11. Immunosuppressive activity of human cord-blood lipoproteins

    International Nuclear Information System (INIS)

    Forte, T.M.; Davis, P.A.; Curtiss, L.K.

    1985-01-01

    It is now known that the role of plasma lipoproteins is multifunctional. More recently it has been shown that lipoproteins may regulate immune responses as well. Low-density lipoproteins carrying apolipoprotein B (apoB) are known to suppress phytohemagglutinin (PHA) activated lymphocytes by inhibiting DNA synthesis. More recently, an immunoregulatory role has been described for another apolipoprotein, apoE, which is found in low quantities in normal plasma. In these studies with human umbilical-cord blood the authors were intrigued by two factors: the low level of LDL and hence apoB, and the elevated quantity of apoE. This study examines the hypothesis that apoE may regulate lymphocyte function in the human fetus

  12. Proliferation Resistance and Safeguards by Design: The Safeguardability Assessment Tool Provided by the INPRO Collaborative Project &apos;'INPRO'&apos; (Proliferation Resistance and Safeguardability Assessment)

    International Nuclear Information System (INIS)

    Haas, E.; Chang, H.-L.; Phillips, J.R.; Listner, C.

    2015-01-01

    Since the INPRO Collaborative Project on Proliferation Resistance and Safeguardability Assessment Tools (PROSA) was launched in 2011, Member State experts have worked with the INPRO Section and the IAEA Department of Safeguards to develop a revised methodology for self-assessment of sustainability in the area of proliferation resistance of a nuclear energy system (NES). With the common understanding that there is &apos;&apos;no proliferation resistance without safeguards&apos;&apos; the revised approach emphasizes the evaluation of a new &apos;User Requirement&apos; for &apos;'safeguardability'&apos;, that combines metrics of effective and efficient implementation of IAEA Safeguards including &apos;'Safeguards-by-Design'&apos; principles. The assessment with safeguardability as the key issue has been devised as a linear process evaluating the NES against a &apos;&apos;Basic Principle&apos;&apos; in the area of proliferation resistance, answering fundamental questions related to safeguards: 1) Do a State&apos;s legal commitments, policies and practices provide credible assurance of the exclusively peaceful use of the NES, including a legal basis for verification activities by the IAEA? 2) Does design and operation of the NES facilitate the effective and efficient implementation of IAEA safeguards? To answer those questions, a questionnaire approach has been developed that clearly identifies gaps and weaknesses. Gaps include prospects for improvements and needs for research and development. In this context, the PROSA approach assesses the safeguardability of a NES using a layered &apos;&apos;Evaluation Questionnaire&apos;&apos; that defines Evaluation Parameters (EP), EP-related questions, Illustrative Tests and Screening Questions to present and structure the evidence of findings. An integral part of the assessment process is Safeguards-by-Design, the identification of potential diversion, misuse and concealment strategies (coarse diversion path

  13. Searle&apos;s"Dualism Revisited"

    Energy Technology Data Exchange (ETDEWEB)

    P., Henry

    2008-11-20

    A recent article in which John Searle claims to refute dualism is examined from a scientific perspective. John Searle begins his recent article &apos;Dualism Revisited&apos; by stating his belief that the philosophical problem of consciousness has a scientific solution. He then claims to refute dualism. It is therefore appropriate to examine his arguments against dualism from a scientific perspective. Scientific physical theories contain two kinds of descriptions: (1) Descriptions of our empirical findings, expressed in an every-day language that allows us communicate to each other our sensory experiences pertaining to what we have done and what we have learned; and (2) Descriptions of a theoretical model, expressed in a mathematical language that allows us to communicate to each other certain ideas that exist in our mathematical imaginations, and that are believed to represent, within our streams of consciousness, certain aspects of reality that we deem to exist independently of their being perceived by any human observer. These two parts of our scientific description correspond to the two aspects of our general contemporary dualistic understanding of the total reality in which we are imbedded, namely the empirical-mental aspect and the theoretical-physical aspect. The duality question is whether this general dualistic understanding of ourselves should be regarded as false in some important philosophical or scientific sense.

  14. OPEC&apos;s strategies

    Energy Technology Data Exchange (ETDEWEB)

    Wirl, Franz [Vienna Univ. (Austria). Faculty of Business, Economics and Statistics

    2012-09-15

    This paper investigates rationale explanations of OPEC&apos;s strategies. Accounting for market characteristics in particular the sluggishness of demand and supply allows to explain price jumps as rational OPEC strategies from a narrow economic perspective (up and down) as well as from political objectives (at least up) due to the political payoff from standing up against the &apos;West&apos;. Although the temptation to accrue this political payoff was and remains high, the narrow economic profit motive coupled with an imperfect cooperation among OPEC members explains past price volatility and high prices much better than the usual reference to political events. A more specific prediction is that OPEC will switch back to setting prices since the current quantity strategy encourages oil importing countries to appropriate rents in particular in connection with the need to mitigate global warming. (orig.)

  15. Chances and perspectives of hybrid vehicles; &apos;&apos;Chancen und Perspektiven von Hybridfahrzeugen&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Taenzer, Guillem [IZES gGmbH, Saarbruecken (Germany)

    2009-07-01

    It is still a challenge for the global automotive industry to build environment friendly and sustainable cars. One of the main questions is which possibilities and prospects short- and long term can be used to maintain the mobility standard today? Hybrid cars could be a short term option (such as 10 to 20 years) to serve as temporary solution. In conjunction with bio fuel hybrid cars could be a sustainable solution - but the today&apos;s availability of bio fuel doesn&apos;t cover the current and future demand of bio fuel. In this context the foodstuff production and the cultivation of monocultures shouldn&apos;t be disregarded. The enhancements of electrical components by hybrid cars allows to get access to the potential of electro mobility (middle term perspectives), even in conjunction with a fuel cell (long term perspectives). Still unresolved are the quantitative allocation of hydrogen (by renewable energy) and the infrastructure of a hydrogen system. (orig.)

  16. On the universality of the &apos;'smile'&apos;-gap in the density of states of a chaotic Josephson junction

    Energy Technology Data Exchange (ETDEWEB)

    Reutlinger, Johannes; Belzig, Wolfgang [University of Konstanz, Department of Physics (Germany); Nazarov, Yuli [Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft (Netherlands); Glazman, Leonid [Department of Physics, Yale University, New Haven, CT (United States)

    2015-07-01

    The superconducting proximity effect strongly modifies the local density of states in chaotic Josephson junctions. Recently we found that besides the well-known minigap a secondary gap appears just below the superconducting gap edge Δ in the limit of a large Thouless energy E{sub Th} >or similar Δ. To check the universality of this novel gap phenomenon we study the effect of nonideal contacts and show that the &apos;'smile'&apos;-gap crucially depends on the transmission eigenvalue distribution. In a next step we use the random matrix method to investigate the &apos;'smile'&apos;-gap. This allows us to approach the statistics of Andreev levels, going beyond the quasiclassical Greens function method. It turns out that the hard gap edge softens similar to what is already known from the minigap.

  17. The &apos;'Stadtkante'&apos; building at Dusseldorf. Representative address of the Metro Group; Die Stadtkante in Duesseldorf. Repraesentative Adresse der Metro Group

    Energy Technology Data Exchange (ETDEWEB)

    Zerres, E.

    2006-07-01

    The &apos;Stadtkante&apos; building of the Metro Group was commissioned in June 2005. The building houses offices and a shopping mall. It has an aesthetically pleasing architecture and interesting technical features. (orig.)

  18. The &apos;daddy&apos; of them all

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-08-01

    Krupp Fordertechnik - acknowledged as one of the leading companies in bulk materials handling - remains a prime provider for such equipment for power station, either already built or under construction. The company was recently awarded the contract for equipment for Israel Electric Corp&apos;s Hadera power station near Tel Aviv. The article describes the operations here. 3 photos.

  19. Linoleum: a &apos;green&apos; flooring option

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2002-07-01

    &apos;Green&apos; building materials may be defined as being made of materials and by processes that have low impact on the environment. Linoleum is an example of a sustainable &apos;green&apos; building material. It is durable, easy to repair, is inherently antimicrobial, and has low-cost maintenance. Unlike most other floor coverings, linoleum has naturally occurring anti-static properties, making it easy to clean, since dust and dirt will not adhere to it. The ingredients in linoleum are linseed oil, resin, limestone, wood flour, pigments and jute, all obtainable from natural sources. Vibrant colours for the flooring are created by using organic pigments with no heavy metals such as lead or calcium which, consequently, pose no threat to the environment. Linoleum is also biodegradable. It can be put into a landfill, where it will decompose; in some parts of the world it is incinerated to produce electricity. When used as feedstock for electricity, used linoleum products have an energy content of 18.6 MJ/kg, which is equivalent to coal. As no toxic or corrosive gases are released, the need for gas purification is avoided.

  20. The &apos;&apos;Hybrid Effect&apos;&apos;. Influence of hybridisation on the durability of automatic transmissions; Der &apos;'Hybrid-Effekt'&apos;. Einfluss der Hybridisierung auf die Lebensdauer von Automatikgetrieben

    Energy Technology Data Exchange (ETDEWEB)

    Lavall, Thomas [ZF Getriebe GmbH, Friedrichshafen (Germany)

    2009-07-01

    The series development of hybrid systems in combination with the new ZF 8-speed automatic transmissions contains also for the testing several aspects of challenge the complex overall system with additional loads, components and functions requires new definitions of testing volumes and load collectives with an ideal integration of testing expertise of all parties involved. This paper describes how, already in an early development stage of the fully hybridised 8-speed transmission system, specific load collectives have been developed with the aid of simulation. So the &apos;'hybrid-effect'&apos; as an additional load and its influence on the durability compared to non hybridised applications could be identified. Also it is shown how testing collectives have been adapted in practice to the hybrid specific needs to the point of a specific assembly of a test bench. The ZF testing concept for hybridised automatic transmissions has the ability of an early and efficient verification of the production readiness also securing highest possible series production quality for prospective hybrid projects. (orig.)

  1. Resource consumption of Germany - indicators and definitions. Development of a glossary on the concept of &apos;'resources'&apos; and calculation of missing characteristic data of resources consumption for further political analysis; Ressourcenverbrauch von Deutschland - aktuelle Kennzahlen und Begriffsbestimmungen. Erstellung eines Glossars zum &apos;'Ressourcenbegriff'&apos; und Berechnung von fehlenden Kennzahlen des Ressourcenverbrauchs fuer die weitere politische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Schuetz, Helmut; Bringezu, Stefan [Wuppertal Institut fuer Klima, Umwelt, Energie GmbH, Wuppertal (Germany). Forschungsgruppe 3: Stoffstroeme und Ressourcenmanagement

    2008-02-15

    The goals of the reported study are: - to prepare a glossary on the term &apos;'Resources'&apos; in order to support communication based on a harmonised resource term and associated terms and - to provide key data on resource use in Germany in time series since 1991 up to the most recent year for which data were available (2004 in general), and to attribute results to the resource terms. Results achieved are presented and discussed below by the following sections: Provision of a glossary on the term &apos;'resource'&apos;, use of the term &apos;'resource'&apos; at different levels, and provision of data and derived indicators for resource consumption in time series. First, a list of the relevant publications in the topic field &apos;'resources'&apos; was provided and co-ordinated with the client. This publication list is given in the annex to this report. On basis of national and international sources a glossary was provided which clearly describes and comments the resource term, its sub-terms and associated terms. This glossary is in the annex to this report. (orig.)

  2. SSI&apos;s review of SKB&apos;s RD and D programme 2001

    Energy Technology Data Exchange (ETDEWEB)

    Hedberg, Bjoern; Larsson, Carl-Magnus; Wiebert, Anders [and others

    2002-08-01

    In the report SSI&apos;s review of SKB&apos;s RD and D programme 2001 is presented. In the review SSI comments, among other things, the decision making process, the need for a strategy document, SKB&apos;s safety and system analysis and SKB&apos;s biosphere studies.

  3. An alternative realization of &apos;t Hooft&apos;s quantum determinism

    Energy Technology Data Exchange (ETDEWEB)

    Sadiq, M., E-mail: sadiq@qau.edu.p [Department of Physics, Quaid-i-Azam University, Islamabad 45320 (Pakistan); Ghafoor, F. [Centre for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan)

    2010-11-15

    We present an alternative to &apos;t Hooft&apos;s mechanism relating a deterministic system to a 1D quantum oscillator. We argue that it is possible to map &apos;t Hooft&apos;s ontological space onto an irreducible representation of a 2D isotropic oscillator. A direct group contraction procedure can then be applied to achieve the correspondence.

  4. ApoE and the role of very low density lipoproteins in adipose tissue inflammation

    Science.gov (United States)

    Our goal was too identify the role of triglyceride-rich lipoproteins and apoE, a major apolipoprotein in triglyceride-rich lipoproteins, in adipose tissue inflammation with high-fat diet induced obesity. Male apoE-/- and C57BL/6J wild-type mice fed high fat diets for 12 weeks were assessed for metab...

  5. Zitterbewegung in Bogoliubov&apos;s System

    International Nuclear Information System (INIS)

    Li Yan; Su Hong-Yi; Chen Jing-Ling; Zhang Fu-Lin; Wu Chun-Feng; Leong-Chuan Kwek

    2015-01-01

    We show that Bogoliubov&apos;s quasiparticle in superfluid 3 He-B undergoes the Zitterbewegung, as a free relativistic Dirac&apos;s electron does. The expectation value of position, as well as spin, of the quasiparticle is obtained and compared with that of the Dirac&apos;s electron. In particular, the Zitterbewegung of Bogoliubov&apos;s quasiparticle has a frequency approximately 10 5 lower than that of an electron, rendering a more promising experimental observation. (general)

  6. Solar tank. &apos;Solar ship&apos; and solar development project at Freiburg; Sonne im Tank. &apos;Sonnenschiff&apos; und Solarsiedlung in Freiburg

    Energy Technology Data Exchange (ETDEWEB)

    Alle, N.

    2007-05-15

    In the &apos;Vauban&apos; district of the German city of Freiburg, 59 plusenergy terrace houses and one block of offices and shops were constructed during the past five years. The latter is named &apos;solar ship&apos; and has nine penthouses on its roof which generate more power than they consume. The building is 125 m long and is both a building and a power station. (orig.)

  7. Proposal of a simple screening method for a rapid preliminary evaluation of &apos;&apos;heavy metals&apos;&apos; mobility in soils of contaminated sites

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Valentina; Chiusolo, Francesca; Cremisini, Carlo [ENEA - Italian Agency for New Technologies, Energy and Environment, Rome (Italy). Section PROTCHIM

    2010-09-15

    Risks associated to &apos;&apos;heavy metals&apos;&apos; (HM) soil contamination depend not only on their total content but, mostly, on their mobility. Many extraction procedures have been developed to evaluate HM mobility in contaminated soils, but they are generally time consuming (especially the sequential extraction procedures (SEPs)) and consequently applicable on a limited number of samples. For this reason, a simple screening method, applicable even &apos;&apos;in field&apos;&apos;, has been proposed in order to obtain a rapid evaluation of HM mobility in polluted soils, mainly focused on the fraction associated to Fe and Mn oxide/hydroxides. A buffer solution of trisodium citrate and hydroxylamine hydrochloride was used as extractant for a single-step leaching test. The choice of this buffered solution was strictly related to the possibility of directly determining, via titration with dithizone (DZ), the content of Zn, Cu, Pb and Cd, which are among the most representative contaminants in highly mineralised soils. Moreover, the extraction solution is similar, aside from for the pH value, which is the one used in the BCR SEP second step. The analysis of bivalents ions through DZ titration was exploited in order to further simplify and quicken the whole procedure. The proposed method generically measures, in few minutes, the concentration of total extractable &apos;&apos;heavy metals&apos;&apos; expressed as molL{sup -1} without distinguishing between elements. The proposed screening method has been developed and applied on soil samples collected from rural, urban and mining areas, representing different situation of soil contamination. Results were compared with data obtained from the BCR procedure. The screening method demonstrated to be a reliable tool for a rapid evaluation of metals mobility. Therefore, it could be very useful, even &apos;&apos;in field&apos;&apos;, both to guide the sampling activity on site and to monitor the efficacy of the subsequent

  8. Inorganic profile of some Brazilian medicinal plants obtained from ethanolic extract and &apos;&apos;in natura&apos;&apos; samples

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, M.O.M.; de Sousa, P.T.; Salvador, V.L.R.; Sato, I.M.

    2004-10-03

    The Anadenathera macrocarpa, Schinus molle, Hymenaea courbaril, Cariniana legalis, Solidago microglossa and Stryphnodendron barbatiman, were collected &apos;&apos;in natura&apos;&apos; samples (leaves, flowers, barks and seeds) from different commercial suppliers. The pharmaco-active compounds in ethanolic extracts had been made by the Mato Grosso Federal University (UFMT). The energy-dispersive x-ray fluorescence (ED-XRF) spectrometry was used for the elemental analysis in different parts of the plants and respective ethanolic extracts. The Ca, Cl, Cu, Fe, K, Mg, Mn, Na, Ni, P, Rb, S, Sr and Zn concentrations were determined by the fundamental parameters method. Some specimens showed a similar inorganic profile for &apos;&apos;in natura&apos;&apos; and ethanolic extract samples and some ones showed a distinct inorganic profile. For example, the Anadenathera macrocarpa showed a similar concentration in Mg, P, Cu, Zn and Rb elements in &apos;&apos;in natura&apos;&apos; and ethanolic extract samples; however very different concentration in Na, S, Cl, K , Ca, Mn, Fe and Sr was observed in distinctive samples. The Solidago microglossa showed the K, Ca, Cl, S, Mg, P and Fe elements as major constituents in both samples, suggesting that the extraction process did not affect in a considerable way the &apos;&apos;in natura&apos;&apos; inorganic composition. The elemental composition of the different parts of the plants (leaves, flowers, barks and seeds) has been also determined. For example, the Schinus molle specimen showed P, K, Cl and Ca elements as major constituents in the seeds, Mg, K and Sr in the barks and Mg, S, Cl and Mn in the leaves, demonstrating a differentiated elementary distribution. These inorganic profiles will contribute to evaluate the quality control of the Brazilian herbaceous trade and also will assist to identify which parts of the medicinal plants has greater therapeutic effect.

  9. Prospects and risks for young technology companies. Chancen und Risiken junger Technologieunternehmen; Ergebnisse des Modellversuchs &apos;&apos;Foerderung technologieorientierter Unternehmensgruendungen&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kulicke, M. (Fraunhofer-Institut fuer Systemtechnik und Innovationsforschung (ISI), Karlsruhe (Germany)); Bayer, K.; Braeunling, G.; Ewers, H.J.; Gerybadze, A.; Mayer, M.; Mueller, R.; Wein, T.; Wupperfeld, U.

    1993-01-01

    The book summarizes the insights gained from the model project &apos;&apos;Promotion of the establishment of technology-oriented companies&apos;&apos;. The manifold results on capital and consulting requirements, turnover and activity growth, factors determining success and survival and on the problems that arise during the starting phase broaden the informational basis for potential founders, their financers, and for promotion institutions. (orig.). 29 figs.

  10. Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l&apos;aide des isotopes {sup 131}I et {sup 15}N d&apos;un cas d&apos;hypoproteinemie essentielle

    Energy Technology Data Exchange (ETDEWEB)

    Dubert, A.; Coursaget, J.; Fallot, P.; Royer, P. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Hopital des Enfants Malades, 75 - Paris (France)

    1959-07-01

    Hypoproteinaemia both human and experimental has been studied with the help of nuclear labelling. A comparative study has been made of the fate of serum proteins labelled by an endogenous path after administration of nitrogen-15 glycine and also of serum albumin labelled by exogenous path using iodine-131. We have determined the biological period of the serum albumin and serum globulins and also the magnitude of the vascular and extravascular pools of serum albumin. In this way it has been possible to measure the speed of replacement of plasma proteins. A presentation of results taken from both clinical observation and experiment leads to a discussion on the pathogenic mechanism of hypoproteinaemia. (author) [French] Les hypoproteinemies humaine et experimentale ont ete explorees a l&apos;aide d&apos;indicateurs nucleaires. Une etude comparative du devenir des proteines seriques marquees par voie endogene, apres administration de glycocolle-{sup 15}N et de l&apos;albumine serique marquee par voie exogene a l&apos;iode-131 a ete realisee. On a determine la periode biologique de la serumalbumine et des globulines seriques ainsi que la grandeur des &apos;pools&apos; vasculaire et extravasculaire de la serumalbumine. Il a ete ainsi possible d&apos;evaluer la vitesse de renouvellement des proteines plasmatiques. La confrontation des resultats tires de l&apos;observation clinique et de l&apos;experimentation conduit a une discussion sur le mecanisme pathogenique de l&apos;hypoproteinemie. (auteur)

  11. Effects of nocturnal aircraft noise on sleep: results from the &apos;&apos;quiet air traffic&apos;&apos; project; Wirkungen des Nachtfluglaerms auf den Schlaf: Ergebnisse aus dem Projekt &apos;&apos;Leiser Flugverkehr&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Samel, A.; Basner, M.; Maass, H.; Mueller, U.; Quehl, J.; Wenzel, J. [Deutsches Zentrum fuer Luft- und Raumfahrt (DLR) in der Helmholtz-Gemeinschaft (HGF), Inst. fuer Luft- und Raumfahrtmedizin, Koeln (Germany)

    2005-07-01

    In 192 sleep-healthy subjects (18 to 65 y) effects of nocturnal aircraft noise on sleep, stress, performance and subjective factors were investigated in 2240 nights under laboratory and field conditions. In the sleep lab, 112 volunteers were subjected to aircraft noise events by varying numbers and noise levels during 9 nights within a period of 13 nights. 16 further subjects served as control group (i.e. without any noise). 64 subjects were studied in the vicinity of Cologne-Bonn airport during 9 nights. Polysomnographical and acoustical recordings, determination of excretion rates of stress hormones from night urines, performance tests and questionnaires were conducted during all days for the assessment of nocturnal aircraft noise effects. By simultaneous recording of electrophysiological and acoustical data the probability of noise induced awakenings was estimated. Performance and most of psychological parameters did not show significant dose-effect relationships, whereas annoyance did. Epinephrine and norepinephrine did not change under aircraft noise, cortisol did change only in the lab. In the lab, a comparison between all noisy nights and noise-free baseline nights exhibited a non-significant 2-min. reduction of sleep and a 4-min. decrease of slow-wave sleep. In the field, awakenings caused by aircraft noise were detected above a threshold of 33 dB(A) &apos;&apos;at the sleeper&apos;s ear&apos;&apos;. All effects were much less pronounced in the field than in the lab. For the first time, precise dose-effect curves between maximum aircraft noise event levels and electrophysiologically detectable awakenings, and a threshold were empirically established. The results of these studies broadens the knowledge on aircraft noise induced sleep disturbances and immediate consequences for the next day. (orig.)

  12. &apos;Heat Market Campaign&apos; of the German coal mining industry

    Energy Technology Data Exchange (ETDEWEB)

    Dach, G.

    1983-12-22

    The &apos;&apos;Heat Market Campaign&apos;&apos;, presented in June &apos;83 by experts of all fields of coal mining, investigates the possibilities of coal sales promotion. The article reviews the main data of the heat market and discusses the &apos;&apos;Heat Market Campaign&apos;&apos; under the aspects of coal policy and energy policy. The campaign was started with the objectives of energy supply assurance in the Federal Republic of Germany, energy cost reduction on the consumer side, and stabilisation and development of coal markets not affected by the steel crisis. Sales goald on the household, trade and industrial sector are quantified, and obstacles preventing further expansion of the heat market are discussed. Apart from the mining industry&apos;s marketing concept for the heat market, there is also the possibility of receiving financial aid by the Federal government.

  13. &apos;Minergie&apos; modernisation - Test in practice; Praxistest Minergie-Modernisierung

    Energy Technology Data Exchange (ETDEWEB)

    Ruetter, H.; Ruetter-Fischbacher, U. [Ruetter und Partner, Soziooekonomische Forschung und Beratung, Rueschlikon (Switzerland); Haessig, W. [Haessig Sustech GmbH - Ingenieurbuero fuer Minergie und nachhaltige Gebaeudetechnik, Uster (Switzerland); Jakob, M. [TEP Energy GmbH, CEPE ETH, Zuerich (Switzerland)

    2008-07-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) examines the results obtained in practice concerning the use of the &apos;Minergie&apos; low energy consumption standard. Experience gained with &apos;Minergie&apos; refurbishment projects is reviewed and the critical points and constraints found are discussed. Further, recommendations for improvements in the use of the &apos;Minergie&apos; standard are made. The study is based on questions posed to building owners in the German speaking part of Switzerland who have carried out refurbishment projects to meet &apos;Minergie&apos; standards as well as questions posed to those who did not adhere to &apos;Minergie&apos; standards in the refurbishment of their buildings. The reasons quoted for using / not using the standard are listed and discussed. Possible tightening of energy regulations concerning renovation work are discussed. The recommendations resulting from the survey are also noted and discussed.

  14. Scientists from all over the world attend the &apos;&apos;Frederic Joliot/Otto Hahn Summer School 2009&apos;&apos; at the Karlsruhe Institute of Technology (KIT); Wissenschaftler aus aller Welt bei der &apos;&apos;Frederic Joliot/Otto Hahn Summer School 2009&apos;&apos; am Karlsruhe Institute of Technologie (KIT)

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Espinoza, Victor Hugo; Fischer, Ulrich [Karlsruhe Inst. of Tech. (KIT), Campus Nord/Inst. for Neutron Physics and Reactor Tech. (INR), Eggenstein-Leopoldshafen (Germany)

    2009-11-15

    The &apos;&apos;Frederic Joliot/Otto Hahn Summer School&apos;&apos; is organized each year alternately by the Karlsruhe Institute of Technology and the Commissariat a l&apos;Energie Atomique (CEA), Cadarache. This year&apos;s Summer School, the 15th since its foundation, was run at the Advanced Training Center (FTU) of KIT Campus Nord on August 26 to September 4. The key topic this year was &apos;&apos;The Challenges in Implementing Fast Reactor Technology.&apos;&apos; These are the items discussed: Principles and challenges of future fast reactor designs, Fuels, fuel cycle, and recycling of minor actinides, Innovative cladding tube and structural materials, Special aspects of coolants and the challenges they pose, Fast reactor safety. Experts from 8 leading international research establishments and universities presented and discussed with the 58 participants from 16 countries the current state of the art and the latest development trends in the topics listed above. (orig.)

  15. Three ways to storage solution. &apos;&apos;Lead or Lithium?&apos;&apos;. This is not the only basic issue in a storage system; Drei Wege zur Speicherloesung. &apos;&apos;Blei oder Lithium?&apos;&apos; Dies ist nicht die einzige Grundsatzfrage bei einem Speichersystem

    Energy Technology Data Exchange (ETDEWEB)

    Welter, Philippe; Siemer, Jochen

    2013-06-15

    The number of solar power storage systems offered is now in the hundreds, if one includes all possible product combinations. We show in the following pages a selection of examples of typical solutions, which are by the KfW program &apos;&apos;Renewable Energy - Storage&apos;&apos; eligible&apos;&apos;. With various modifications, they can be divided into three groups: battery inverter with built-in storage, external storage on the DC side of the PV system and stand-alone systems on AC power. [German] Die Zahl der angebotenen Solarstromspeichersysteme geht mittlerweile in die Hunderte, wenn man alle moeglichen Produktkombinationen einbezieht. Wir zeigen auf den folgenden Seiten eine exemplarische Auswahl an typischen Loesungen, die mittels KfW-Programm &apos;&apos;Erneuerbare Energien - Speicher&apos;&apos; foerderfaehig sind. Mit diversen Modifikationen lassen sie sich in drei Gruppen einteilen: Akkuwechselrichter mit integriertem Speicher, externe Speicher an der Gleichstromseite der Photovoltaikanlage und Stand-alone-Systeme am Wechselstromnetz.

  16. Report on the surveys in fiscal 1999 on foundations for establishing industrial technology strategies. Technological strategies by fields (Human life engineering field); 1999 nendo sangyo gijutsu senryaku sakutei kiban chosa hokokusho. Bun&apos;yabetsu gijutsu senryaku (ningen seikatsu kogaku bun&apos;ya)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This paper describes the surveys in fiscal 1999 on establishing industrial technology strategies in the human life engineering field. The human life engineering is an engineering to identify scientifically humans and their living characteristics, and apply them to products, systems, and environment building. Market size for the human living related industries is more than two trillion yen, whose annual growth rate is 9%. Discussions were given on problems that hinder technological innovations in this field. What lacks is the comprehensive strategic conception, and insufficient is the structural approach by related organizations. Technological systems for designing have not been established, and technological foundations relative to human characteristics and living characteristics are not well arranged. Methods to evaluate research achievements have not been established, and the works on proposing international standards are weak. Insufficiency in human resource nurturing is also an issue. As the future prospect and strategies, such fields as psychology, recognition, and sensitivity are important for the seeds technologies, and so are the measurement of supportive technologies, and information processing. The human living engineering aims at supporting safety, freedom from care, and high-quality life, realizing industrial and technological competitiveness of the world top groups, and forming societies with activity and high quality. (NEDO)

  17. Chlorogenic acid protects against atherosclerosis in ApoE-/- mice and promotes cholesterol efflux from RAW264.7 macrophages.

    Directory of Open Access Journals (Sweden)

    Chongming Wu

    Full Text Available Chlorogenic acid (CGA is one of the most abundant polyphenols in the human diet and is suggested to be a potential antiatherosclerotic agent due to its proposed hypolipidemic, anti-inflammatory and antioxidative properties. The aim of this study was to evaluate the effect of CGA on atherosclerosis development in ApoE(-/- mice and its potential mechanism. ApoE(-/- mice were fed a cholesterol-rich diet without (control or with CGA (200 and 400 mg/kg or atorvastatin (4 mg/kg for 12 weeks. During the study plasma lipid and inflammatory parameters were determined. Treatment with CGA (400 mg/kg reduced atherosclerotic lesion area and vascular dilatation in the aortic root, comparable to atorvastatin. CGA (400 mg/kg also significantly decreased plasma levels of total cholesterol, triglycerides and low-density lipoprotein-cholesterol as well as inflammatory markers. Supplementation with CGA or CGA metabolites-containing serum suppressed oxidized low-density lipoprotein (oxLDL-induced lipid accumulation and stimulated cholesterol efflux from RAW264.7 cells. CGA significantly increased the mRNA levels of PPARγ, LXRα, ABCA1 and ABCG1 as well as the transcriptional activity of PPARγ. Cholesterol efflux assay showed that three major metabolites, caffeic, ferulic and gallic acids, significantly stimulated cholesterol efflux from RAW264.7 cells. These results suggest that CGA potently reduces atherosclerosis development in ApoE(-/- mice and promotes cholesterol efflux from RAW264.7 macrophages. Caffeic, ferulic and gallic acids may be the potential active compounds accounting for the in vivo effect of CGA.

  18. Differential response of the skin in young and old rats to a combination of X-rays and &apos;wet&apos; or &apos;dry&apos; hyperthermia

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, R.; Hopewell, J.W.

    1986-11-01

    Hind feet of group of female rats aged 7, 14 and 52 weeks were X-irradiated at 20, 25 or 30 Gy. Hyperthermia (42.5/sup 0/C for 1 h) was carried out immediately following irradiation using either &apos;wet&apos; or &apos;dry&apos; heat, by immersion in water or fluorocarbon liquid. Results demonstrated that &apos;wet&apos; heat produced a consistently greater enhancement of the irradiation damage than &apos;dry&apos;. The thermal enhancement ratio for irradiation plus &apos;wet&apos; heat was approximately 1.5 and for irradiation plus &apos;dry&apos; heat 1.17 to 1.39. Immersion of the feet in fluorocarbon liquid at 37/sup 0/C did not significantly modify the irradiation response of the skin. The lower thermal enhancement ratios obtained using immersion in fluorocarbon liquid at 42.5/sup 0/C are close to those obtained in large animal studies and similar to the limited amount of data from clinical studies where microwave or ultrasound heating techniques were used. It has been demonstrated that there are large age-related differences in the response of the rat foot skin to irradiation alone. It has also been shown, using rats of the same age, that the response to irradiation plus hyperthermia was less age dependent.

  19. Jack Michael&apos;s Motivation

    Science.gov (United States)

    Miguel, Caio F.

    2013-01-01

    Among many of Jack Michael&apos;s contributions to the field of behavior analysis is his behavioral account of motivation. This paper focuses on the concept of "motivating operation" (MO) by outlining its development from Skinner&apos;s (1938) notion of "drive." Conceptually, Michael&apos;s term helped us change our focus on…

  20. &apos;Modernization property&apos; of our country is visualized / TAISEI; Wagakuni no &apos;kindaika isan&apos; wo eizoka / taiseisensetsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-11-10

    TAISEI was about rapidly promoted from Days of the Tokugawa shogunate over Meiji and Taisho this, and the documentary film which focused on building and &apos;the modernization property&apos; which are related to industry and traffic and civil engineering which made the base of the our country development was planned and was produced. The title of the movie is &apos;travel to the Japan modernization property&apos;. The movie which really introduced such modern age property is rare, and it s as an image material precious. It tries to pick up main thing, The oldest lighthouse &apos;Mikomotojima Island lighthouse (Shizuoka Prefect.1870)&apos; and covers Shiga Prefecture and Kyoto prefecture,&apos;The Lake Biwa hydrophobic&apos;, in our country, the first gravitational concrete dam &apos;Nunobiki Gohnmatsu dam, Kobe City, 1900&apos;Length furnace for the cement baking which remains in Yamaguchi Prefect. &apos;The ONODA CEMENT (Pacific Ocean cement) sake bottle furnace&apos;. In becoming modernization property which widely remains in our country and so on the guide person, Mr. Shinbo Minami of the illustrator has introduced it. The narration is the Mr. platform step of the actress. Still, screening party of this movie is done in the following schedule (admission free). The detailed query is Japanese movie new Co. (141-0021 2-10-17 Kami-Osaki, Shinagawa ku, Tokyo), TEL 03-3442-7251 FAX 03-3442-7360. (translated by NEDO)

  1. From Crex mutualization to clinical audit; De la mutualisation des comites de retour d&apos;experience (Crex) a l&apos;audit des pratiques cliniques

    Energy Technology Data Exchange (ETDEWEB)

    Debouck, F. [Departement securite operationnelle, Air France Consulting, 95 - Roissy-CDG (France); Petit, H.B. [AFM42, 78 - Chambourcy (France); Lartigau, E. [Centre Oscar-Lambret, departement universitaire de radiotherapie, 59 - Lille (France); Universite Lille Nord-de-France, 59 - Lille (France)

    2010-10-15

    In mid-2004, following a Mission nationale d&apos;expertise et d&apos;audits hospitaliers (MeaH) proposal, three voluntary cancer centres started setting up a safety procedure in radiotherapy. Their work made it possible to single out the need to continue elaborating a repository, aiming at a &apos;minimal written reference&apos;, to take into account the human factor as one of the four families of factors contributing to a systemic deviation and to build collectively, in radiotherapy departments, the experience feedback committee (comite de retour d&apos;experience [Crex]). Formalizing a comite de retour d&apos;experience is unavoidable in any safety-management system (SMM or MGS). The comite de retour d&apos;experience enables every active member of a department to listen to any of the events of the month (incidents and precursors), to select the event which will be under scrutiny for the next systemic analysis (Orion{sup C} method) and above all to choose the most appropriate correcting action and ensure its proper implementation. That approach has been approved and then acknowledged by the Autorite de surete nucleaire (ASN) before being extended to the other radiotherapy departments. The use of the comite de retour d&apos;experience, which is a safety management tool, should not be limited to a local circle of insiders, but shared to benefit everybody. Putting comite de retour d&apos;experience together - a move that was hoped for and brought up as soon as the tool was created - is now being implemented. Several initiatives have already permitted to assess its collective interest; other steps have yet to be taken to enable a true collective sharing of experience. On this basis, the definition of quality/safety practices in radiotherapy will allow the professionals to implement clinical audits in 2012. (authors)

  2. &apos;&apos;Confession statement against the nuclear nation&apos;&apos;. The protestant church in Germany and the conflicts concerning nuclear energy 1970 - 1990; &apos;&apos;Bekennen gegen den Atomstaat&apos;&apos;. Die evangelischen Kirchen in der Bundesrepublik Deutschland und die Konflikte um die Atomenergie 1970-1990

    Energy Technology Data Exchange (ETDEWEB)

    Schuering, Michael [Florida Univ., Gainesville, FL (United States)

    2015-07-01

    The book on &apos;&apos;Confession statement against the nuclear nation&apos;&apos; discusses the conflicts of the protestant church in Germany concerning nuclear energy in 1970 - 1990. The introduction covers the state of research and the historical sources. The following chapters discuss the issues philosophic-ideological fundamentals: atomic energy and theology, the political church, the new protest culture and comparative perspectives: the catholic perspective, Three Mile Island&apos;s shadow.

  3. Re-evaluation of the criticality experiments of the &apos;&apos;Otto Hahn Nuclear Ship&apos;&apos; reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lengar, I.; Snoj, L.; Rogan, P.; Ravnik, M. [Jozef Stefan Institute, Ljubljana (Slovenia)

    2008-11-15

    Several series of experiments with a FDR reactor (advanced pressurized light water reactor) were performed in 1972 in the Geesthacht critical facility ANEX. The experiments were performed to test the core prior to its usage for the propulsion of the first German nuclear merchant ship &apos;'Otto-Hahn'&apos;. In the present paper a calculational re-evaluation of the experiments is described with the use of the up-to date computer codes (Monte-Carlo code MCNP5) and nuclear data (ENDF/B-VI release 6). It is focused on the determination of uncertainties in the benchmark model of the experimental set-up, originating mainly from the limited set of information still available about the experiments. Effects of the identified uncertainties on the multiplication factor were studied. The sensitivity studies include parametric variation of material composition and geometry. The combined total uncertainty being found 0.0050 in k{sub eff}, the experiments are qualified as criticality safety benchmark experiments. (orig.)

  4. Resonant light power buildup in ALPS, a &apos;&apos;light shining through a wall&apos;&apos;-experiment

    Energy Technology Data Exchange (ETDEWEB)

    Meier, Tobias; Danzmann, Karsten; Willke, Benno [Max-Planck-Institut fuer Gravitationsphysik, Albert Einstein Institut (Germany); Institut fuer Gravitationsphysik, Leibniz Universitaet Hannover, Callinstrasse 38, D-30167 Hannover (Germany); Ehret, Klaus; Ghazaryan, Samvel; Knabbe, Axel; Lindner, Axel; List, Jenny; Meyer, Niels; Notz, Dieter; Redondo, Javier; Ringwald, Andreas [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Frede, Maik; Hildebrandt, Matthias [Laserzentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover (Germany); Wiedemann, Guenter [Hamburger Sternwarte, Gojenbergsweg 112, D-21029 Hamburg (Germany)

    2009-07-01

    We report on the first successfull application of a new experimental technique to search for weakly interacting sub-eV particles (WISPs) coupling to photons. As part of the ALPS experiment located at DESY in Hamburg, this technique uses an optical resonator to enhance the power inside a HERA dipole magnet on the production side of a typical &apos;&apos;light shining through a wall&apos;&apos;-experiment. We use a frequency doubled continuous-wave laser emitting 0.6 W of power at 532 nm that is stabilized to a linear optical resonator with 8 m length. On resonance we achieve a circulating power of 34 W within the magnet. With this we obtained sensitivities corresponding to a coupling strength of g{approx}5.10{sup -7} GeV{sup -1} for interactions of axion-like particles and photons. The experimental setup and possible improvements are described and compared with common experimental designs with pulsed lasers.

  5. Imaging of bridging vein thrombosis in infants with abusive head trauma: the &apos;&apos;Tadpole Sign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Hahnemann, Maria L.; Kinner, Sonja; Schweiger, Bernd [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Bajanowski, Thomas [University Hospital Essen, Institute of Legal Medicine, Essen (Germany); Karger, Bernd; Pfeiffer, Heidi; Wittschieber, Daniel [University Hospital Muenster, Institute of Legal Medicine, Muenster (Germany)

    2014-10-03

    Abusive head trauma (AHT) in infants is usually diagnosed using a multi-disciplinary approach by investigating the circumstances and identifying morphological indicators, for example, subdural hematomas (SDHs), subdural hygromas (SDHys), retinal haemorrhages and encephalopathy. The present morphological study investigates the incidence, radiological characteristics and non-radiological co-factors of bridging vein thrombosis (BVT) in infants with AHT. From 2002 to 2013, computed tomography (CT) and magnetic resonance imaging (MRI) material of 628 infants aged 0-2 years were analysed retrospectively. If available, medicolegal expert opinions were additionally considered. Cases with SDHs and/or SDHys were identified and systematically evaluated as to the presence and characteristics of BVT. SDHs and/or SDHys were present in 29 of the 81 cases exhibiting morphological abnormalities in the initial CT. Among these, 11 cases (40 %) had BVT (mean age = 5.0 months). BVT could be best depicted in the T1-weighted spin echo and T2*/susceptibility-weighted MRI. In one case, BVT could be depicted indirectly using time-of-flight MR venography. The predominant (73 %) BVT shape was found to be tadpole-like (&apos;&apos;Tadpole Sign&apos;&apos;). In the absence of appropriate accidental trauma, BVT appears to be a strong indicator of AHT. Therefore, the BVT/Tadpole Sign represents compelling cause to search for other signs of AHT. (orig.)

  6. The quantum realm of the &apos;&apos;Little Sibling&apos;&apos; of the Big Rip singularity

    International Nuclear Information System (INIS)

    Albarran, Imanol; Bouhmadi-López, Mariam; Cabral, Francisco; Martín-Moruno, Prado

    2015-01-01

    We analyse the quantum behaviour of the &apos;&apos;Little Sibling&apos;&apos; of the Big Rip singularity (LSBR) [1]. The quantisation is carried within the geometrodynamical approach given by the Wheeler-DeWitt (WDW) equation. The classical model is based on a Friedmann-Lemaître-Robertson-Walker Universe filled by a perfect fluid that can be mapped to a scalar field with phantom character. We analyse the WDW equation in two setups. In the first step, we consider the scale factor as the single degree of freedom, which from a classical perspective parametrises both the geometry and the matter content given by the perfect fluid. We then solve the WDW equation within a WKB approximation, for two factor ordering choices. On the second approach, we consider the WDW equation with two degrees of freedom: the scale factor and a scalar field. We solve the WDW equation, with the Laplace-Beltrami factor-ordering, using a Born-Oppenheimer approximation. In both approaches, we impose the DeWitt (DW) condition as a potential criterion for singularity avoidance. We conclude that in all the cases analysed the DW condition can be verified, which might be an indication that the LSBR can be avoided or smoothed in the quantum approach

  7. Myxofibrosarcoma: prevalence and diagnostic value of the &apos;&apos;tail sign&apos;&apos; on magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lefkowitz, Robert A.; Landa, Jonathan; Hwang, Sinchun; Panicek, David M. [Memorial Sloan-Kettering Cancer Center, Department of Radiology, New York, NY (United States); Weill Medical College of Cornell University, New York, NY (United States); Zabor, Emily C.; Moskowitz, Chaya S. [Memorial Sloan-Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY (United States); Agaram, Narasimhan P. [Memorial Sloan-Kettering Cancer Center, Department of Pathology, New York, NY (United States)

    2013-06-15

    Myxofibrosarcoma frequently shows curvilinear extensions of high T2 signal that also enhance on magnetic resonance imaging; these &apos;'tails'&apos; represent fascial extension of tumor at histopathological examination. This study was performed to determine whether the tail sign is helpful in distinguishing myxofibrosarcoma from other myxoid-containing neoplasms. The study group consisted of 44 patients with pathologically proven myxofibrosarcoma; the control group consisted of 52 patients with a variety of other myxoid-predominant tumors. Three musculoskeletal radiologists independently evaluated T2-weighted (and/or short-tau inversion recovery) and post-contrast MR images for the presence of one or more enhancing, high-signal intensity, curvilinear projections from the primary mass. Sensitivity and specificity for the diagnosis of myxofibrosarcoma were calculated for each reader. Interobserver variability was assessed with kappa statistic and percentage agreement. A tail sign was deemed present in 28, 30, and 34 cases of myxofibrosarcoma and in 11, 9, and 5 of the controls for the three readers respectively, yielding a sensitivity of 64-77 % and a specificity of 79-90 %. The interobserver agreement was moderate-to-substantial (kappa = 0.626). The tail sign at MRI is a moderately specific and sensitive sign for the diagnosis of myxofibrosarcoma relative to other myxoid-containing tumors. (orig.)

  8. Comparability of Conflict Opportunities in Human-to-Human and Human-to-Agent Online Collaborative Problem Solving

    Science.gov (United States)

    Rosen, Yigal

    2014-01-01

    Students&apos; performance in human-to-human and human-to-agent collaborative problem solving assessment task is investigated in this paper. A secondary data analysis of the research reported by Rosen and Tager (2013) was conducted in order to investigate the comparability of the opportunities for conflict situations in human-to-human and…

  9. Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes

    Energy Technology Data Exchange (ETDEWEB)

    Lasrich, Dorothee; Bartelt, Alexander [Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg (Germany); Grewal, Thomas, E-mail: thomas.grewal@sydney.edu.au [Faculty of Pharmacy A15, The University of Sydney, Sydney, NSW 2006 (Australia); Heeren, Joerg, E-mail: heeren@uke.de [Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg (Germany)

    2015-09-10

    Several studies in mice indicate a role for apolipoprotein E (APOE) in lipid accumulation and adipogenic differentiation in adipose tissue. However, little is yet known if APOE functions in a similar manner in human adipocytes. This prompted us to compare lipid loading and expression of adipocyte differentiation markers in APOE-deficient and control adipocytes using the differentiated human mesenchymal stem cell line hMSC-Tert as well as primary human and mouse adipocytes as model systems. Differentiated hMSC-Tert were stably transduced with or without siRNA targeting APOE while murine adipocytes were isolated from wild type and Apoe knockout mice. Human APOE knockdown hMSC-Tert adipocytes accumulated markedly less triglycerides compared to control cells. This correlated with strongly decreased gene expression levels of adipocyte markers such as adiponectin (ADIPOQ) and fatty acid binding protein 4 (FABP4) as well as the key transcription factor driving adipocyte differentiation, peroxisome proliferator activator receptor gamma (PPARG), in particular the PPARG2 isoform. Similarly, differentiation of murine Apoe-deficient adipocytes was characterized by reduced gene expression of Adipoq, Fabp4 and Pparg. Interestingly, incubation of APOE-deficient hMSC-Tert adipocytes with conditioned media from APOE3-overexpressing adipocytes or APOE-containing Very Low Density Lipoprotein (VLDL) partially restored triglyceride accumulation, but were unable to induce adipocyte differentiation, as judged by expression of adipocyte markers. Taken together, depletion of endogenous APOE in human adipocytes severely impairs lipid accumulation, which is associated with an inability to initiate differentiation. - Highlights: • Immortalized human mesenchymal stem cells were used to study adipocyte development. • Knockdown of endogenous APOE lead to impaired lipid accumulation and adipogenesis. • APOE supplementation partially restored lipid accumulation but not differentiation.

  10. Functional and morphological parameters with tissue characterization of cardiovascular magnetic imaging in clinically verified &apos;&apos;infarct-like myocarditis&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schwab, Johannes [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Radiology; Rogg, H.J.; Pauschinger, M.; Fessele, K. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology; Bareiter, T.; Baer, I. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Neuroradiology; Loose, R. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Radiology

    2016-04-15

    Cardiac magnetic resonance (CMR) has increasingly proved to be a valuable diagnostic tool for evaluating patients with suspected myocarditis. The objective of this study was to evaluate the diagnostic value of functional and morphological parameters including tissue characterization in patients with &apos;&apos;infarct-like myocarditis&apos;&apos;. 43 patients with clinically verified cases of &apos;&apos;infarct-like myocarditis&apos;&apos; (median time to MRI scanning after admission for acute symptoms 3 days) and 35 control patients matched by age and sex were included in this retrospective case control study. In this study we used a 1.5 T MRI scanner conducting steady-state-free-precession sequences, T2-weighted imaging, T1-weighted imaging before and after contrast administration and late gadolinium enhancement sequences. According to the recommendations for CMR diagnosis of myocarditis (Lake Louise consensus criteria), a scan was positive for acute myocarditis if 2 of 3 CMR criteria were present. 30 % of the patients with &apos;&apos;infarct-like myocarditis&apos;&apos; had a reduced left ventricular ejection fraction, 11 % had an increased LV end-diastolic volume index and 35 % had an increased LV mass index. The sensitivity of wall motion abnormalities was 63 % with a regional distribution in 49 %. In 47 % of cases regional wall motion abnormalities were present in the lateral left ventricular segments. Pericardial effusions were discovered in 65 % of cases with a circular appearance in 21 % and focal manifestation in 44 %. The diagnostic sensitivity, specificity, and accuracy of CMR in patients with &apos;&apos;infarct-like myocarditis&apos;&apos; were 67 %, 100 % and 82 %, respectively. The LGE alone was the most sensitive test parameter with 86 %, providing a specificity of 100 % and accuracy of 92 %. Our study results can be applied to the subgroup of patients with &apos;&apos;infarct-like myocarditis&apos;&apos;, where we found that LGE alone was the

  11. Energy-related renovation in the world heritage. Retrofitting &apos;Glas-Hoffmann&apos; buildings, Berlin; Energetische Sanierung im Weltkulturerbe. Sanierung &apos;Glas-Hoffmann&apos;-Bauten, Berlin

    Energy Technology Data Exchange (ETDEWEB)

    Brensing, Christian

    2012-11-01

    Between 1955 and 1959, the housing estate at the Schiller park in Berlin-Wedding (Federal Republic in Germany) established in the 1920ies was expanded by four-storey house lines, the so-called Glas-Hoffmann buildings. Since 2008, this ensemble belongs to the Unesco World Heritage. In improving the thermal insulation of the building envelope and the adaptation of the building services to today&apos;s standards, therefore the architectural aesthetics of these buildings should not be endangered. The retrofitting was a pilot project of the research project &apos;&apos;Monument and energy - Postwar Modernism&apos;&apos;.

  12. Presence of human papillomavirus-18 and Epstein-Barr virus in a squamous cell carcinoma of the tongue in a 20-year-old patient. Case report and review of the current literature; Presence dans un cancer epidermoide de la langue d&apos;un papillomavirus HPV-18 et d&apos;un virus d&apos;Epstein-Barr chez une patiente de 20 ans. Case-report et revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, R.M.; Pradier, O.; Christiansen, H.; Schmidberger, H. [Georg-August Gottingen Universitat, Dept. of Radiotherapy (Germany); Fuzesi, L. [Georg-August Gottingen Universitat, Dept. of Pathology (Germany)

    2004-08-01

    We report on a squamous cell carcinoma of the tongue in a 20-year-old woman with co-infection of the tumor with human papilloma virus type 18 and Epstein-Barr virus.To our knowledge, this is the first case of co-infection in carcinoma of the tongue to be reported. We review the present data and theories concerning viral onco-genesis of oral carcinomas. (author)

  13. Strangers and Orphans: Knowledge and Mutuality in Mary Shelley&apos;s "Frankenstein"

    Science.gov (United States)

    Gomez, Claudia Rozas

    2013-01-01

    Paulo Freire consistently upheld humanization and mutuality as educational ideals. This article argues that conceptualizations of knowledge and how knowledge is sought and produced play a role in fostering humanization and mutuality in educational contexts. Drawing on Mary Shelley&apos;s novel "Frankenstein," this article focuses on the…

  14. The &apos;last mile&apos; of data handling: Fermilab&apos;s IFDH tools

    International Nuclear Information System (INIS)

    Lyon, Adam L; Mengel, Marc W

    2014-01-01

    IFDH (Intensity Frontier Data Handling), is a suite of tools for data movement tasks for Fermilab experiments and is an important part of the FIFE[2] (Fabric for Intensity Frontier [1] Experiments) initiative described at this conference. IFDH encompasses moving input data from caches or storage elements to compute nodes (the &apos;last mile&apos; of data movement) and moving output data potentially to those caches as part of the journey back to the user. IFDH also involves throttling and locking to ensure that large numbers of jobs do not cause data movement bottlenecks. IFDH is realized as an easy to use layer that users call in their job scripts (e.g. &apos;ifdh cp&apos;), hiding the low level data movement tools. One advantage of this layer is that the underlying low level tools can be selected or changed without the need for the user to alter their scripts. Logging and performance monitoring can also be added easily. This system will be presented in detail as well as its impact on the ease of data handling at Fermilab experiments.

  15. Development of the &apos;&apos;space AFM&apos;&apos; for interplanetary missions

    Energy Technology Data Exchange (ETDEWEB)

    Howald, L.; Mueller, D. [Nanosurf AG, Liestal (Switzerland); Akiyama, T.; Gautsch, S.; Staufer, U. [Inst. of Microtechnology, Univ. of Neuchatel (Switzerland); Hidber, H.R.; Tonin, A. [Inst. of Physics, Univ. of Basel (Switzerland); Niedermann, P. [CSEM Neuchatel (Switzerland); Pike, T. [Jet Propulsion Lab., Pasadena, CA (United States)

    2000-01-01

    One of the next Mars missions of NASA will fly a project that aims to characterize the Martian dust and soil, identifying its potential undesirable and harmful effects on with human explorers and associated hardware systems. Optical microscopy will be used to measure the size, shape and size distribution of Martian dust particles. Particle sizes between 10 nm and a few micrometers are expected. A second goal of the microscopy experiment is to determine the hardness of the dust particles by scratching them against substrates of different hardness. The hardware development comprises of a microfabricated array of 8 cantilevers that are addressed sequentially, a small electromagnetic scanner with large scan range, compact and robust control electronics, all of which can withstand radiation exposure, low temperatures, and the shocks and vibrations of the journey to Mars. (orig.)

  16. Conference-debate &apos;When nuclear science provides health care&apos; - Proceedings; conference debat &apos;Quand le nucleaire soigne&apos; - Recueil des presentations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-03-15

    At the occasion of the 2. issue of the &apos;Industry week, the &apos;French society of nuclear energy (SFEN) young generation&apos; and the &apos;Women in Nuclear (WIN)&apos; associations have organised in partnership with Nucleopolis and the Cherbourg-Normandie Techno-pole, a conference day on the topic &apos;why and how nuclear energy is used for cancer therapy&apos;. Professors Jacques Foos, Jean Datchary and Denis Agostini were invited to treat this question. This document is the compilation of their 3 presentations: 1 - The discovery, principle and medical applications of radioactivity (J. Foos, CNAM); 2 - Cancer diagnosis and therapy with nuclear medicine (D. Agostini, CHU Caen); 3 - From diagnosis to therapy: the various radiotherapy methods (J. Datchary)

  17. "Experience Is Our Great and Only Teacher": A Peircean Reading of Wim Wenders&apos; "Wings of Desire"

    Science.gov (United States)

    Strand, Torill

    2014-01-01

    Wim Wenders&apos; film "Wings of Desire" tells the story of an angel who wishes to become mortal in order to know the simple joy of human life. Told from the angel&apos;s point of view, the film is shot in black and white. But at the very instant the angel perceives the realities of human experience, the film blossoms into colour. In…

  18. The fifth international symposium &apos;&apos;atomic cluster collisions&apos;&apos;. ISACC 2011. Book of Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The Fifth International Symposium &apos;&apos;Atomic Cluster Collisions&apos;&apos; (ISACC 2011) will take place in July 21-25, 2011 in Berlin, Germany. The venue of the meeting will be the St.-Michaels-Heim a lovely place located within a garden area of Berlin-Grunewald. The ISACC 2011 is organized by the Fritz-Haber-Institute of the Max- Planck Society along with the King Saud University, Rhiyadh and by the Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main, Germany. ISACC started as the international symposium on atomic cluster collisions in St. Petersburg, Russia in 2003. The second ISACC was held at the GSI, Darmstadt, Germany in 2007. Both first and second symposia were satellites of the International Conferences on Photonic Electronic and Atomic Collisions (ICPEAC). The third ISACC has returned to St. Petersburg, Russia in 2008. The last ISACC took place in Ann Arbor, again as a satellite meeting of the ICPEAC. Initially the symposium was mainly focused on dynamics of atomic clusters, especially in atomic cluster collisions, but since then its scope has been widened significantly to include dynamics of nanosystems, biomolecules, and macromolecules with the emphasis on the similarity of numerous essential clustering phenomena arising in different branches of physics, chemistry, and biology. After the four ISACC meetings it has become clear that there is a need for an interdisciplinary conference covering a broad range of topics related to the Dynamics of Systems on a Nanoscale. Therefore in 2010 it was decided to expand upon this series of meetings with a new conference organized under the new title &apos;&apos;Dynamics of Systems on the Nanoscale&apos;&apos;, the DySoN Conference, since this title better reflects the interdisciplinary character of the earlier ISACC meetings embracing all the topics of interest under a common theme. The first DySoN Conference took place in Rome, Italy in 2010. The fifth ISACC symposium will be again a

  19. &apos;Plug-in hybrids and smart grids&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Horbaty, R.

    2008-07-01

    This presentation made at the Swiss 2008 research conference on traffic by Robert Horbaty from the ENCO Energy Consulting AG takes a look at how the amount of renewable energy in the electricity mains and the efficiency of mobility can be increased and pollution reduced at the same time. The integration of energy supply and electrically-powered mobility to help reduce the effects of intermittent power production from renewable sources of energy is discussed. The &apos;smart&apos; technologies needed for integration and management are looked at. Examples of pilot projects are quoted and the effects of the liberalisation of the electricity markets are discussed. The advantages offered by plug-in hybrid vehicles are noted and load-shifting possibilities are discussed. Trends towards mains regulation using bi-directional charging facilities are noted.

  20. Phantom inflation and the &apos;Big Trip&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez-Diaz, Pedro F. [Colina de los Chopos, Instituto de Matematicas y Fisica Fundamental, Consejo Superior de Investigaciones Cientificas, Serrano 121, 28006 Madrid (Spain)]. E-mail: p.gonzalezdiaz@imaff.cfmac.csic.es; Jimenez-Madrid, Jose A. [Colina de los Chopos, Instituto de Matematicas y Fisica Fundamental, Consejo Superior de Investigaciones Cientificas, Serrano 121, 28006 Madrid (Spain)

    2004-08-19

    Primordial inflation is regarded to be driven by a phantom field which is here implemented as a scalar field satisfying an equation of state p={omega}{rho}, with {omega}-1. Being even aggravated by the weird properties of phantom energy, this will pose a serious problem with the exit from the inflationary phase. We argue, however, in favor of the speculation that a smooth exit from the phantom inflationary phase can still be tentatively recovered by considering a multiverse scenario where the primordial phantom universe would travel in time toward a future universe filled with usual radiation, before reaching the big rip. We call this transition the &apos;Big Trip&apos; and assume it to take place with the help of some form of anthropic principle which chooses our current universe as being the final destination of the time transition.

  1. Environmental education project &apos;Mico-Estrela Track&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Vicente, Ana Paula Camargo de; Magalhaes, Milton Pinto Magalhaes; Silva, Simone Rodrigues da; Pinheiro, Roberta Vieira Nunes; Torres, Carlos Alberto Rodrigues; Silveira, Jeanete [PETROBRAS Transporte S.A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil)

    2009-12-19

    Senador Canedo fuel storage terminal is situated in the Cerrado biome and implements the policy of promoting improvements in the preservation of its Green Belt by working out the Environmental Education Project &apos;Mico-Estrela7 Track&apos;, aimed at stimulating the preservation, protection, landscape beauty and defense of scientific sources of the Cerrado through environmental sensibilization and rational use of the existing natural resources. In the area of the track (1.5 ha) alone 352 plants have been identified, totaling 97 different species that are distributed in 36 families. The implementation of the project will contribute to strengthen the relations with the local community, like dwellers, teachers and pupils of the municipal network of Senador Canedo, as well as co-workers of the unit, thus reaffirming the commitment of the company to socio-environmental responsibility. (author)

  2. &apos;Dynamical Supersymmetry Breaking, with Flavor&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Craig, Nathaniel; Essig, Rouven; /Stanford U., Phys. Dept. /SLAC; Franco, Sebastian; Kachru, Shamit; /Santa Barbara, KITP /UC, Santa Barbara; Torroba, Gonzalo; /Stanford U., Phys. Dept. /SLAC /Santa Barbara, KITP /UC, Santa Barbara

    2010-08-26

    We explore calculable models with low-energy supersymmetry where the flavor hierarchy is generated by quark and lepton compositeness, and where the composites emerge from the same sector that dynamically breaks supersymmetry. The observed pattern of Standard Model fermion masses and mixings is obtained by identifying the various generations with composites of different dimension in the ultraviolet. These &apos;single-sector&apos; supersymmetry breaking models give rise to various spectra of soft masses which are, in many cases, quite distinct from what is commonly found in models of gauge or gravity mediation. In typical models which satisfy all flavor-changing neutral current constraints, both the first and second generation sparticles have masses of order 20 TeV, while the stop mass is a few TeV. In other cases, all sparticles obtain masses of order a few TeV predominantly from gauge mediation, even though the first two generations are composite.

  3. Managing the &apos;gaps&apos; in a regimen of control - operational decision making in nuclear power

    International Nuclear Information System (INIS)

    McDougall, S.J.

    2014-01-01

    Nuclear power performance has significantly improved over the last thirty years. This improvement has been based on a philosophy of control. That is, for each issue that must be managed to achieve safe performance, a pre-determined constraint must be established. In addition to the barriers that were designed into the plant, a large range of programs, processes and procedures have been developed to direct the activities of anyone associated with the plant. The premise is that following pre-determined procedures, in a diligent way, will support ongoing plant safety. But what if an issue arises for which there is no procedure? For serious situations, emergency procedures exist to guide operations personnel to place the plant in a safe state. However, the vast majority of issues are much more mundane and form a part of the daily life in the plant. In these cases the nuclear industry has been encouraging the use of an &apos;Operational Decision Making&apos; (ODM) process. This paper will review ODM as practiced within the context of the governing paradigm of control. The paper will show the strengths of the process and areas for development. ODM is an important tool for managers within the complex socio-technical system that is nuclear power today. This paper summarises key points from a research thesis completed by the author to meet the requirements of an MSc program in &apos;Human Factors and System Safety&apos;. (author)

  4. Accumulation of cyanobacterial toxins in freshwater &apos;seafood&apos; and its consequences for public health: A review

    Energy Technology Data Exchange (ETDEWEB)

    Ibelings, Bas W. [Eawag, Swiss Federal Institute of Aquatic Sciences and Technology, Centre of Ecology, Evolution and Biogeochemistry, Seestrasse 79, CH-6047 Kastanienbaum (Switzerland); Netherlands Institute of Ecology, Centre for Limnology, Rijksstraatweg 6, 3631 AC, Nieuwersluis (Netherlands)], E-mail: bas.ibelings@eawag.ch; Chorus, Ingrid [German Federal Environment Agency, Corrensplatz 1, 14195 Berlin (Germany)], E-mail: ingrid.chorus@uba.de

    2007-11-15

    This review summarizes and discusses the current understanding of human exposure to cyanobacterial toxins in &apos;seafood&apos; collected from freshwater and coastal areas. The review consists of three parts: (a) the existing literature on concentrations of cyanobacterial toxins in seafood is reviewed, and the likelihood of bioaccumulation discussed; (b) we derive cyanotoxin doses likely to occur through seafood consumption and propose guideline values for seafood and compare these to guidelines for drinking water; and (c) we discuss means to assess, control or mitigate the risks of exposure to cyanotoxins through seafood consumption. This is discussed in the context of two specific procedures, the food specific HACCP-approach and the water-specific Water Safety Plan approach by the WHO. Risks of exposure to cyanotoxins in food are sometimes underestimated. Risk assessments should acknowledge this and investigate the partitioning of exposure between drinking-water and food, which may vary depending on local circumstances. - Accumulation of cyanobacterial toxins in freshwater &apos;seafood&apos;.

  5. Managing the &apos;gaps&apos; in a regimen of control - operational decision making in nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    McDougall, S.J. [Leading Safety Culture Inc., Port Elgin, ON (Canada)

    2014-07-01

    Nuclear power performance has significantly improved over the last thirty years. This improvement has been based on a philosophy of control. That is, for each issue that must be managed to achieve safe performance, a pre-determined constraint must be established. In addition to the barriers that were designed into the plant, a large range of programs, processes and procedures have been developed to direct the activities of anyone associated with the plant. The premise is that following pre-determined procedures, in a diligent way, will support ongoing plant safety. But what if an issue arises for which there is no procedure? For serious situations, emergency procedures exist to guide operations personnel to place the plant in a safe state. However, the vast majority of issues are much more mundane and form a part of the daily life in the plant. In these cases the nuclear industry has been encouraging the use of an &apos;Operational Decision Making&apos; (ODM) process. This paper will review ODM as practiced within the context of the governing paradigm of control. The paper will show the strengths of the process and areas for development. ODM is an important tool for managers within the complex socio-technical system that is nuclear power today. This paper summarises key points from a research thesis completed by the author to meet the requirements of an MSc program in &apos;Human Factors and System Safety&apos;. (author)

  6. Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice.

    Science.gov (United States)

    Chukkapalli, Sasanka S; Velsko, Irina M; Rivera-Kweh, Mercedes F; Zheng, Donghang; Lucas, Alexandra R; Kesavalu, Lakshmyya

    2015-01-01

    Periodontal disease (PD) develops from a synergy of complex subgingival oral microbiome, and is linked to systemic inflammatory atherosclerotic vascular disease (ASVD). To investigate how a polybacterial microbiome infection influences atherosclerotic plaque progression, we infected the oral cavity of ApoE null mice with a polybacterial consortium of 4 well-characterized periodontal pathogens, Porphyromonas gingivalis, Treponema denticola, Tannerealla forsythia and Fusobacterium nucleatum, that have been identified in human atherosclerotic plaque by DNA screening. We assessed periodontal disease characteristics, hematogenous dissemination of bacteria, peripheral T cell response, serum inflammatory cytokines, atherosclerosis risk factors, atherosclerotic plaque development, and alteration of aortic gene expression. Polybacterial infections have established gingival colonization in ApoE null hyperlipidemic mice and displayed invasive characteristics with hematogenous dissemination into cardiovascular tissues such as the heart and aorta. Polybacterial infection induced significantly higher levels of serum risk factors oxidized LDL (p Periodontal microbiome infection is associated with significant decreases in Apoa1, Apob, Birc3, Fga, FgB genes that are associated with atherosclerosis. Periodontal infection for 12 weeks had modified levels of inflammatory molecules, with decreased Fas ligand, IL-13, SDF-1 and increased chemokine RANTES. In contrast, 24 weeks of infection induced new changes in other inflammatory molecules with reduced KC, MCSF, enhancing GM-CSF, IFNγ, IL-1β, IL-13, IL-4, IL-13, lymphotactin, RANTES, and also an increase in select inflammatory molecules. This study demonstrates unique differences in the host immune response to a polybacterial periodontal infection with atherosclerotic lesion progression in a mouse model.

  7. Finishing report for the &apos;SolcelleInverter&apos; project

    Energy Technology Data Exchange (ETDEWEB)

    Boekhoej Kjaer, S.

    2005-03-01

    The main objective for this research project was to develop an inverter for the AC module, where one PV module is equipped with its own dedicated inverter, and connected to the grid. A topology, among many different candidates, has been selected, based on analysis&apos;s. The inverter has been optimized in respect to cost, reliability, and efficiency, and a prototype has been build. (au)

  8. MRI of &apos;brain death&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Nishino, Shigeki; Itoh, Takahiko; Tuchida, Shohei; Kinugasa, Kazushi; Asari, Shoji; Nishimoto, Akira (Okayama Univ. (Japan). School of Medicine); Sanou, Kazuo

    1990-12-01

    Magnetic resonance imaging (MRI) was undertaken for two patients who suffered from severe cerebrovascular diseases and were clinically brain dead. The MRI system we used was Resona (Yokogawa Medical Systems, superconductive system 0.5 T) and the CT apparatus was Toshiba TCT-300. Initial CT and MRI were undertaken as soon as possible after admission, and repeated sequentially. After diagnosis of brain death, we performed angiography to determine cerebral circulatory arrest, and MRI obtained at the same time was compared with the angiogram and CT. Case 1 was a 77-year-old man who was admitted in an unconscious state. CT and MRI on the second day after hospitalization revealed cerebellar infarction. He was diagnosed as brain dead on day 4. Case 2 was a 35-year-old man. When he was transferred to our hospital, he was in cardiorespiratory arrested. Cardiac resuscitation was successful but no spontaneous respiration appeared. CT and MRI on admission revealed right intracerebral hemorrhage. Angiography revealed cessation of contrast medium in intracranial vessels in both of the patients. We found no &apos;flow signal void sign&apos; in the bilateral internal carotid and basilar arteries on MRI images in both cases after brain death. MRI, showing us the anatomical changes of the brain, clearly revealed brain herniations, even though only nuclear findings of &apos;brain tamponade&apos; were seen on CT. But in Case 1, we could not see the infarct lesions in the cerebellum on MR images obtained after brain death. This phenomenon was caused by the whole brain ischemia masking the initial ischemic lesions. We concluded that MRI was useful not only the anatomical display of lesions and brain herniation with high contrast resolution but for obtaining information on cerebral circulation of brain death. (author).

  9. IPSN activity report 1999; Rapport d&apos;activite de l&apos;IPSN 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The &apos;&apos;Institut de Protection et de Surete Nucleaire&apos;&apos; (IPSN), carries out researches and expert studies needed to manage nuclear risks and their consequences on people and environment. These activities cover the installation safety, the radioactive matter transport, the public health and environmental control, the nuclear matters safety and control and the crisis situation management. The IPSN have got also a mission of public information and participates to international actions in the domain of scientific researches or expert&apos;s report. This annual report presents the highlights of the year 1999, information on staff, budgets and geographical situation. Then technical and scientific papers gathers the activities of the year covered by the IPSN: the &apos;&apos;Free Tribune&apos;&apos;, installations and radioactive wastes safety, crisis and nuclear matter management, public health and environment control, international cooperation. (A.L.B.)

  10. &apos;Chernobyl&apos; reaches Norway: the accident, science, and the threat to cultural knowledge

    Energy Technology Data Exchange (ETDEWEB)

    Paine, R. (Memorial Univ. of Newfoundland, St. John' s, NF (Canada))

    1992-07-01

    This report is interested in the transitions that &apos;Chernobyl&apos; underwent in Norway. It &apos;arrived&apos; as a ghastly accident: important cultural routines were disturbed, apprehension ran high, and the country waited for scientists to &apos;repair&apos; the accident. The scourge of radiation, however, still covered much of the countryside of central Norway. Reindeer pastures were heavily polluted, and among Saami (Lapp) groups there arose a cognitive sense of disruption to a way of life. Ambivalent relations - at times cooperative, more often adversarial - developed among the Saami in respect to the outside experts who strove to bring the radiation problem under control. The report (with anthropological fieldwork) strives to show how much of the problem of &apos;Chernobyl&apos;, in this later phase, has to do with the different nature of the claims of two kinds of knowledge: the outside scientists&apos; and the Saami pastoralists. (author).

  11. Human Factors Review Plan

    Energy Technology Data Exchange (ETDEWEB)

    Paramore, B.; Peterson, L.R. (eds.)

    1985-12-01

    &apos;'Human Factors&apos;&apos; is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

  12. Scenarios for an integrated sustainability policy - using the example of the &apos;&apos;Sustainable City 2030&apos;&apos;. Vol. 2; Szenarien fuer eine integrierte Nachhaltigkeitspolitik - am Beispiel: Die nachhaltige Stadt 2030. Bd. 2. Teilbericht &apos;&apos;Kreislaufstadt 2030&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Verbuecheln, Maic; Grabow, Busso; Uttke, Angela; Schwausch, Mandy [Deutsches Inst. fuer Urbanistik (DiFu), Berlin (Germany); Gassner, Robert [Institut fuer Zukunftsstudien und Technologiebewertung gGmbH (IZT), Berlin (Germany)

    2013-04-15

    The partial report &apos;&apos;Recycling City 2030&apos;&apos; was prepared for the Federal Environment Agency (Dessau, Federal Republic of Germany) as a part of the project &apos;&apos;Scenarios for an integrated sustainability policy - the example of &apos;The Sustainable City 2030 &apos;'&apos;. This partial report is based on research activities of the German Institute of Urban Affairs (Berlin, Federal Republic of Germany) and Institute for Futures Studies and Technology Assessment (Berlin, Federal Republic of Germany). The objectives of this partial report are: (1) Description of the challenges and trends in urban regions; (2) Recycling city and its importance in the current debate on sustainability; (3) Identification and optimization of existing cycle approaches in urban habitats; (4) Analysis of the actual state as well as designation of developments and constraints; (5) Discussion on the interface between the sectors; (6) Options for action for the interaction between the actors in interdisciplinary topics; (7) Outline of ways and perspectives of the implementation of the &apos;&apos;Recycling City 2030&apos;&apos;.

  13. RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network

    Directory of Open Access Journals (Sweden)

    Babenko Vladimir N.

    2017-09-01

    Full Text Available ApoE expression status was proved to be a highly specific marker of energy metabolism rate in the brain. Along with its neighbor, Translocase of Outer Mitochondrial Membrane 40 kDa (TOMM40 which is involved in mitochondrial metabolism, the corresponding genomic region constitutes the neuroenergetic hotspot. Using RNA-Seq data from a murine model of chronic stress a significant positive expression coordination of seven neighboring genes in ApoE locus in five brain regions was observed. ApoE maintains one of the highest absolute expression values genome-wide, implying that ApoE can be the driver of the neighboring gene expression alteration observed under stressful loads. Notably, we revealed the highly statistically significant increase of ApoE expression in the hypothalamus of chronically aggressive (FDR < 0.007 and defeated (FDR < 0.001 mice compared to the control. Correlation analysis revealed a close association of ApoE and proopiomelanocortin (Pomc gene expression profiles implying the putative neuroendocrine stress response background of ApoE expression elevation therein.

  14. The location selection act or &apos;the Emperor&apos;s new clothes&apos;; Das Standortauswahlgesetz oder &apos;Des Kaisers neue Kleider&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2013-10-15

    As is generally known, the governing parties CDU/CSU and FDP agreed a few weeks ago in the 17{sup th} legislative period of the German Bundestag in a rare show of unanimity, together with the parties SPD and Buendnis 90/Die Gruenen, as well as with the Laender, on a &apos;law to search and select a location for a permanent disposal site for heat-generating radioactive waste products and to change other laws&apos;, in brief a location selection act also called StandAG. The law was received with animated approval from the ranks of the parties - with the exception of the (left-wing) party Die Linke. This praise is a tad bewildering, since the Bundesumweltministerium (Federal Department of the Environment) named solving the task within a single generation as one of the principles for the StandAG, and it was emphasised again and again in the debates about the StandAG that the problem of permanent disposal must not be shifted to the next generation. Conclusion: - The StandAG leads to a postponement of solving the permanent disposal site issue by a least several generations with its predictable, long-winded selection method. - The decision not to explore Gorleben conclusively could lead to the site being permanently (&apos;wasted&apos; or) &apos;burned&apos;. - The de-central, interim disposal site Gorleben is likewise &apos;burned&apos; without having a resilient alternative solution for the glass coquilles that must be taken back. - The people&apos;s protest is exponentiated by the number of the potential sites for the StandAG. - The costs for the alternative site search will not be shifted to the producers of the waste that are obliged by law to deliver the waste because of the financial provisions of the constitution. - The third party protection dogma has not been broken up, which will at least lead to delays in the procedure and will have effects on other major projects in the long run. (orig.)

  15. A neural model for transient identification in dynamic processes with &apos;don&apos;t know&apos; response

    Energy Technology Data Exchange (ETDEWEB)

    Mol, Antonio C. de A. E-mail: mol@ien.gov.br; Martinez, Aquilino S. E-mail: aquilino@lmp.ufrj.br; Schirru, Roberto E-mail: schirru@lmp.ufrj.br

    2003-09-01

    This work presents an approach for neural network based transient identification which allows either dynamic identification or a &apos;don&apos;t know&apos; response. The approach uses two &apos;jump&apos; multilayer neural networks (NN) trained with the backpropagation algorithm. The &apos;jump&apos; network is used because it is useful to dealing with very complex patterns, which is the case of the space of the state variables during some abnormal events. The first one is responsible for the dynamic identification. This NN uses, as input, a short set (in a moving time window) of recent measurements of each variable avoiding the necessity of using starting events. The other one is used to validate the instantaneous identification (from the first net) through the validation of each variable. This net is responsible for allowing the system to provide a &apos;don&apos;t know&apos; response. In order to validate the method, a Nuclear Power Plant (NPP) transient identification problem comprising 15 postulated accidents, simulated for a pressurized water reactor (PWR), was proposed in the validation process it has been considered noisy data in order to evaluate the method robustness. Obtained results reveal the ability of the method in dealing with both dynamic identification of transients and correct &apos;don&apos;t know&apos; response. Another important point studied in this work is that the system has shown to be independent of a trigger signal which indicates the beginning of the transient, thus making it robust in relation to this limitation.

  16. HDL-apoA-I exchange: rapid detection and association with atherosclerosis.

    Directory of Open Access Journals (Sweden)

    Mark S Borja

    Full Text Available High density lipoprotein (HDL cholesterol levels are associated with decreased risk of cardiovascular disease, but not all HDL are functionally equivalent. A primary determinant of HDL functional status is the conformational adaptability of its main protein component, apoA-I, an exchangeable apolipoprotein. Chemical modification of apoA-I, as may occur under conditions of inflammation or diabetes, can severely impair HDL function and is associated with the presence of cardiovascular disease. Chemical modification of apoA-I also impairs its ability to exchange on and off HDL, a critical process in reverse cholesterol transport. In this study, we developed a method using electron paramagnetic resonance spectroscopy (EPR to quantify HDL-apoA-I exchange. Using this approach, we measured the degree of HDL-apoA-I exchange for HDL isolated from rabbits fed a high fat, high cholesterol diet, as well as human subjects with acute coronary syndrome and metabolic syndrome. We observed that HDL-apoA-I exchange was markedly reduced when atherosclerosis was present, or when the subject carries at least one risk factor of cardiovascular disease. These results show that HDL-apoA-I exchange is a clinically relevant measure of HDL function pertinent to cardiovascular disease.

  17. Changes in total and central fat mass after a hypocaloric diet associate with changes of apoC-I in postmenopausal obese women.

    Science.gov (United States)

    Wassef, Hanny; Davignon, Jean; Prud'homme, Denis; Rabasa-Lhoret, Rémi; Faraj, May

    2014-01-01

    We previously reported the secretion of apolipoprotein apoC-I, apoC-II, apoC-III, and apoE from adipose tissue in postmenopausal obese women, suggesting their potential regulation by energy balance in humans. We examined the changes of these apolipoproteins, in relation to changes in cardiometabolic risks, following a hypocaloric diet in overweight/obese women. A total of 137 postmenopausal overweight/obese women who were free of chronic disease were examined at baseline, 56 women of whom were reevaluated following a 6-month hypocaloric diet. At baseline, there was no association between the plasma transferable apolipoproteins with any index of adiposity, insulin sensitivity, lipids, or inflammation, except for apoE with peripheral fat mass (r = 0.18, P hypocaloric diet reduced adiposity, insulin resistance, and inflammatory markers but had no significant effects on plasma transferable apolipoproteins or lipids, whose average concentrations were within normal range at baseline. The changes in total and central, but not peripheral, fat mass associated with changes of apoC-I only (r = 0.28 and r = 0.43; respectively, P < .05). Post-weight-loss apoC-I increased in some women (52%) yet it decreased in others, however there were no differences in cardiometabolic risk factors between the 2 groups. Plasma apoC-I, apoC-II, apoC-III, and apoE are not associated with adiposity, insulin sensitivity, or inflammation in obese but healthy postmenopausal women. Post-weight-loss changes of total and central fat mass associate with changes of apoC-I. Copyright © 2014 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  18. Search for B Meson Decays to eta&apos; eta&apos; K

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2006-05-05

    The authors describe searches for decays of B mesons to the charmless final states {eta}&apos;{eta}&apos;K. The data consist of 228 million B{bar B} pairs produced in e{sup +}e{sup -} annihilation, collected with the BABAR detector at the Stanford Linear Accelerator Center. The 90% confidence level upper limits for the branching fractions are {Beta}(B{sup 0} {yields} {eta}&apos;{eta}&apos;K{sup 0}) < 31 x 10{sup -6} and {Beta}(B{sup +} {yields} {eta}&apos;{eta}&apos;K{sup +}) < 25 x 10{sup -6}.

  19. PubliForum &apos;Electricity and Society&apos;. Citizen Panel Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-01

    In the Citizen Panel&apos;s Report on &apos;Electricity and Society&apos; we present the first results of three intensive week-ends. In this document, 27 Swiss citizens have recorded their opinions on the future of our electricity supply system. Solutions are sought without making claims on having found the ultimate recipe. The recommendations are the result of an assessment made by a representative cross-section of the public - one could almost say &apos;the voice of the people&apos;. They reflect not only the public&apos;s apprehensions and worries, but also their ideas and desires. (authors)

  20. The intern structure of special relativity; La &apos;&apos;structure fine&apos;&apos; de la relativite restreinte

    Energy Technology Data Exchange (ETDEWEB)

    Pierseaux, Y. [Universite Libre de Bruxelles (Belgium)

    1999-07-01

    The author presents the forgotten fact that in 1905 there were 2 restricted theories of relativity: that of Einstein and that of Poincare. These 2 theories were independently formulated, they are very close to each other but are fundamentally different when we consider their basic principles. Poincare&apos;s theory is based on a classical representation of the purely undulatory aspect of light, whereas Einstein stipulates for the quantum aspect of light. Poincare&apos;s theory implies the existence of the ether and asserts the primacy of continuity over discontinuity. The author has based his work on a thorough study of the scientific articles in which Poincare and Einstein explained their ideas. The comparison of these 2 theories sheds light on the evolution of concepts on which the whole modern physics is based. An extended bibliography of works published on special relativity or on related topics is given. (A.C.)

  1. Pipeline control support system, &apos;pipe navigation&apos;; Kanro kanri shien system &apos;kannabi&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-01-10

    &apos;Pipe navigation&apos; is a pipeline control support system which employs GIS/GPS (geographic information system/global positioning system) technology in controlling information of water pipeline and incidental facilities, using a pen note/personal computer as the operating base. These pen computers can be carried to the spot and used in displaying pipeline/incidental equipment and retrieving related information. The main features as follows:(1) Memo preparation is possible at an arbitrary place with handwriting ease. The memo data so prepared can be taken in other terminals and shared.(2) Communication with remote places is possible by transmitting drawings, prepared memo data, etc., as in facsimile (3) Confirmation of the present position and navigation are possible (GPS function), demonstrating power in a restoration work at the time of earthquake for example.(4) Inputting and maintenance of each facility information are possible through the data input support function even by general users easily. (translated by NEDO)

  2. Hill&apos;s formula

    Energy Technology Data Exchange (ETDEWEB)

    Bolotin, Sergey V [Steklov Mathematical Institute, Russian Academy of Sciences, Moscow (Russian Federation); Treschev, Dmitrii V [M. V. Lomonosov Moscow State University, Moscow (Russian Federation)

    2010-07-27

    In his study of periodic orbits of the three-body problem, Hill obtained a formula connecting the characteristic polynomial of the monodromy matrix of a periodic orbit with the infinite determinant of the Hessian of the action functional. A mathematically rigorous definition of the Hill determinant and a proof of Hill&apos;s formula were obtained later by Poincare. Here two multidimensional generalizations of Hill&apos;s formula are given: for discrete Lagrangian systems (symplectic twist maps) and for continuous Lagrangian systems. Additional aspects appearing in the presence of symmetries or reversibility are discussed. Also studied is the change of the Morse index of a periodic trajectory upon reduction of order in a system with symmetries. Applications are given to the problem of stability of periodic orbits. Bibliography: 34 titles.

  3. &apos;Demystifying the hydrogen and fuel cell industry. Where are the investment opportunities in B.C.?&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kettlewell, D. [Royal Roads Univ. and Hydrogen Media, Vancouver, British Columbia (Canada)]. E-mail: hydrogenmedia@telus.net

    2004-07-01

    Human civilization has advanced through history by moving from one finite source of energy to the next. Wood and coal fueled the industrial revolution, while oil and natural gas powered us to a technological age. Exploration and innovation have provided tools to fuel rapid economic growth. However, our seemingly endless appetite for resources and power sources have left barren land, polluted waterways and a contaminated atmosphere. Our explorative human nature and global population growth trends ensures that our appetite for energy will continue to grow exponentially. Embracing sustainable development and integrating eco-efficiencies into industrial development will enable us to reduce and re-use our finite natural resources. The challenge for humanity is to ensure that we do not suffocate on the waste by-product of our economic growth. The world&apos;s ninety-year &apos;production affair&apos; with oil will peak in 2020 as accessible supply begins to decline. Similarly, supply issues with natural gas will force production to decline after 2040. Finite supply forces and carbon pollution concerns are forcing energy alternatives to be considered. Hydrogen is a potential energy elixir considering its ability to generate more concentrated powerful energy with clean water as its only effluent. British Columbia (B.C.) is uniquely positioned to participate in a clean energy solution. This conference paper is a synopsis of a full consulting report that was undertaken on behalf of a Vancouver-based seed capital firm, Renewal Partners. The objective of the report was to examine the history, cycles and future of investments in B.C.&apos;s hydrogen and fuel cell sectors within a macro financial outlook. With a critical eye towards global development, investment recommendations are offered from a B.C. sector perspective. The paper is divided into the following sections: Research Methodology; Hydrogen Overview; Financial Outlook; Canadian Perspective; B.C. Perspective; What

  4. MILLIMETRIC AND SUBMILLIMETRIC OBSERVATIONS OF IRAS 05327+3404 &apos;'HOLOEA'&apos; IN M36

    Energy Technology Data Exchange (ETDEWEB)

    Morata, O.; Ho, P. T. P. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 106, Taiwan (China); Kuan, Y.-J.; Huang, H.-C.; Zhao-Geisler, R. [Department of Earth Sciences, National Taiwan Normal University, 88 Section 4, Ting Chou Road, Taipei 116, Taiwan (China); Magnier, E. A., E-mail: omorata@asiaa.sinica.edu.tw [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2013-09-15

    The transition between the protostar, Class I, and the pre-main-sequence star, Class II, phases is still one of the most uncertain, and important, stages in the knowledge of the process of formation of an individual star because it is the stage that determines the final mass of the star. We observed the young stellar object &apos;'Holoea'&apos;, associated with IRAS 05327+3404, which was classified as an object in the transition between the Class I and Class II phases with several unusual properties, and appears to be surrounded by large amounts of circumstellar material. We used the SMA and BIMA telescopes at millimeter and submillimeter (submm) wavelengths to observe the dust continuum emission and the CO (1-0) and (2-1), HCO{sup +} (1-0) and (3-2), and HCN (1-0) transitions in the region around IRAS 05327+3404. We detected two continuum emission peaks at 1.1 mm: SMM 1, the submm counterpart of IRAS 05327+3404, and SMM 2, {approx}6 arcsec to the west. The emissions of the three molecules show marked differences. The CO emission near the systemic velocity is filtered out by the telescopes, and CO mostly traces the high-velocity gas. The HCO{sup +} and HCN emissions are more concentrated around the central parts of the region, and show several intensity peaks coincident with the submm continuum peaks. We identify two main molecular outflows: a bipolar outflow in an E-W direction that would be powered by SMM 1 and the other in a NE direction, which we associate with SMM 2. We propose that the SMM sources are probably Class I objects, with SMM 1 in an earlier evolutionary stage.

  5. Imaging characteristics of subcutaneous amyloid deposits in diabetic patients: the &apos;&apos;insulin ball&apos;&apos;

    International Nuclear Information System (INIS)

    Tanio, Noriko; Nozaki, Taiki; Matsusako, Masaki; Starkey, Jay; Suzuki, Koyu

    2018-01-01

    The purpose of this study was to describe the imaging characteristics of subcutaneous amyloid deposits occurring at sites of insulin injection, commonly known as &apos;&apos;insulin balls,&apos;&apos; in diabetic patients on ultrasound, CT, and MRI with pathologic correlation. We retrospectively reviewed the radiographic findings of 14 lesions in 9 patients diagnosed with subcutaneous amyloid deposits at our institution between 2005-2015. Three board-certified radiologists analyzed the following: (1) the shape, size, margin, morphologic characteristics, and blood flow on US using the color Doppler signal, (2) shape, size, margin, attenuation, and presence or absence of contrast enhancement on CT, and (3) shape, size, margin, signal intensity, and presence or absence of contrast enhancement on MRI. All lesions showed ill-defined hypovascular subcutaneous nodules with irregular margins. The median diameter of lesions was 50.4 mm on US, 46.8 mm on CT, and 51.4 mm on MRI. The internal echogenicity of subcutaneous amyloid deposits was hypoechoic and heterogeneous on US. All lesions showed isodensity compared to muscle with irregular margins and minimal contrast enhancement on CT. Both T1- and T2-weighted MR images showed low signal intensity compared with subcutaneous fat. Normal diffusion and minimal contrast enhancement were seen. Subcutaneous amyloid deposits which cause insulin resistance are typically ill-defined and heterogeneous hypovascular subcutaneous nodules with irregular margins on imaging that correspond to insulin injection sites. It is also characteristic that T2WI shows low intensity compared with fat on MRI, reflective of the amyloid content. (orig.)

  6. Imaging characteristics of subcutaneous amyloid deposits in diabetic patients: the &apos;&apos;insulin ball&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Tanio, Noriko; Nozaki, Taiki; Matsusako, Masaki; Starkey, Jay [St. Luke' s International Hospital, Department of Radiology, Tokyo (Japan); Suzuki, Koyu [St. Luke' s International Hospital, Department of Pathology, Tokyo (Japan)

    2018-01-15

    The purpose of this study was to describe the imaging characteristics of subcutaneous amyloid deposits occurring at sites of insulin injection, commonly known as &apos;&apos;insulin balls,&apos;&apos; in diabetic patients on ultrasound, CT, and MRI with pathologic correlation. We retrospectively reviewed the radiographic findings of 14 lesions in 9 patients diagnosed with subcutaneous amyloid deposits at our institution between 2005-2015. Three board-certified radiologists analyzed the following: (1) the shape, size, margin, morphologic characteristics, and blood flow on US using the color Doppler signal, (2) shape, size, margin, attenuation, and presence or absence of contrast enhancement on CT, and (3) shape, size, margin, signal intensity, and presence or absence of contrast enhancement on MRI. All lesions showed ill-defined hypovascular subcutaneous nodules with irregular margins. The median diameter of lesions was 50.4 mm on US, 46.8 mm on CT, and 51.4 mm on MRI. The internal echogenicity of subcutaneous amyloid deposits was hypoechoic and heterogeneous on US. All lesions showed isodensity compared to muscle with irregular margins and minimal contrast enhancement on CT. Both T1- and T2-weighted MR images showed low signal intensity compared with subcutaneous fat. Normal diffusion and minimal contrast enhancement were seen. Subcutaneous amyloid deposits which cause insulin resistance are typically ill-defined and heterogeneous hypovascular subcutaneous nodules with irregular margins on imaging that correspond to insulin injection sites. It is also characteristic that T2WI shows low intensity compared with fat on MRI, reflective of the amyloid content. (orig.)

  7. A New Step for &apos;&apos;State-IAEA Cooperation&apos;&apos; Based on the Enhanced Cooperation Program

    International Nuclear Information System (INIS)

    Jo, S.Y.; Kim, M.; Kim, S.

    2015-01-01

    Since joining the IAEA comprehensive safeguards agreements, the ROK has made some exemplary case of implementing the IAEA&apos;s safeguards policy in a State. It&apos;s the results of the ROK Government&apos;s persistent effort for nuclear transparency to maintain its peaceful nuclear activities which is indispensible in Korea. The history of the ROK SSAC development can be reflected on the trajectory of the evolution of the IAEA safeguards. The ROK SSAC has achieved technical capabilities required for IAEA safeguards, which was not possible without cooperation programme with the IAEA. The first memorable moment of the ROK-IAEA cooperation is the enhanced cooperation program for the ROK LWRs in 2001, introducing remote monitoring systems and some changes in interim inspections. The next chance for leveling the ROK SSAC up came with IS implementation. Two parties consulted what should be prepared for efficient implementation of IS through seven times working group meetings. The WG put out IS approaches which have been being applied for the ROK nuclear facilities since 2008. The IS implementation, which is based on the state level approach, allowed the ROK SSAC to get opportunities to improve more its technical capabilities about support for IAEA safeguards activities, developing verification devices and safeguards approaches for pyroprocessing related facilities. The IAEA and the ROK are putting strenuous efforts for strengthening safeguards cooperation based on the Enhanced Cooperation Arrangements which was signed in 2012, discussing the SSAC role in IAEA safeguards activities, joint use equipment, etc. Besides, two parties are considering introducing unannounced inspections at LWRs after several rehearsals. In this paper, the implication and importance of State-IAEA cooperation is presented based on the ROK&apos;s experience with summarizing the brief history of SSAC development and cooperation with the IAEA. (author)

  8. Development of new VOC exposure metrics and their relationship to &apos;&apos;Sick Building Syndrome&apos;&apos; symptoms

    Energy Technology Data Exchange (ETDEWEB)

    Ten Brinke, JoAnn [Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab., Berkeley, CA (United States)

    1995-08-01

    Volatile organic compounds (VOCs) are suspected to contribute significantly to &apos;&apos;Sick Building Syndrome&apos;&apos; (SBS), a complex of subchronic symptoms that occurs during and in general decreases away from occupancy of the building in question. A new approach takes into account individual VOC potencies, as well as the highly correlated nature of the complex VOC mixtures found indoors. The new VOC metrics are statistically significant predictors of symptom outcomes from the California Healthy Buildings Study data. Multivariate logistic regression analyses were used to test the hypothesis that a summary measure of the VOC mixture, other risk factors, and covariates for each worker will lead to better prediction of symptom outcome. VOC metrics based on animal irritancy measures and principal component analysis had the most influence in the prediction of eye, dermal, and nasal symptoms. After adjustment, a water-based paints and solvents source was found to be associated with dermal and eye irritation. The more typical VOC exposure metrics used in prior analyses were not useful in symptom prediction in the adjusted model (total VOC (TVOC), or sum of individually identified VOCs (ΣVOCi)). Also not useful were three other VOC metrics that took into account potency, but did not adjust for the highly correlated nature of the data set, or the presence of VOCs that were not measured. High TVOC values (2--7 mg m-3) due to the presence of liquid-process photocopiers observed in several study spaces significantly influenced symptoms. Analyses without the high TVOC values reduced, but did not eliminate the ability of the VOC exposure metric based on irritancy and principal component analysis to explain symptom outcome.

  9. The data assimilation method &apos;&apos;Latent Heat Nudging&apos;&apos; assessed with the Dynamic State Index

    Energy Technology Data Exchange (ETDEWEB)

    Claussnitzer, Antje [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie; Deutscher Wetterdienst, Offenbach (Germany); Schartner, Thomas; Nevir, Peter; Cubasch, Ulrich [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie; Stephan, Klaus [Deutscher Wetterdienst, Offenbach (Germany)

    2011-04-15

    In April 2007, the German Weather Service (DWD) added the non-hydrostatic limited area model COSMODE to its model chain. COSMO-DE covers mainly Germany and bordering countries and has a horizontal resolution of 2.8 km (0.025 ). An advantage of the COSMO-DE is that deep convection is expected to be resolved explicitly. In order to improve the initial state of COSMO-DE an assimilation of radar derived precipitation rates is applied by using &apos;&apos;Latent Heat Nudging&apos;&apos; (LHN). The aim of LHN is to adjust the model state so that the model will respond by producing a rain rate close to the observed value. In this study, the influence of LHN on diabatic processes is investigated by evaluation of the Dynamic State Index (DSI). The DSI is calculated on both isentropic (DSI{sub {theta}}) and model levels (DSI{sub {sigma}}). To analyse the influence of LHN, model analyses with and without LHN are examined for summer 2009 (June to August). The influence of LHN is also examined in more detail in a case study of a heavy rainfall event on July 18, 2009 where a strong rainfall area was developed on the front side of a trough. Results, based on a statistical investigation and the case study, show that the model with LHN can reproduce the observed rainfall better than the runs without LHN. This is also suggested by a higher correlation between DSI and observed precipitation. The release of latent heat enhances the diabatic processes associated with the formation of additional potential vorticity anomalies resulting in stronger DSI -signals. (orig.)

  10. How do radiologists use the human search engine?

    International Nuclear Information System (INIS)

    Wolfe, Jeremy M.; Evans, Karla K.; Drew, Trafton; Aizenman, Avigael; Josephs, Emilie

    2016-01-01

    Radiologists perform many &apos;visual search tasks&apos; in which they look for one or more instances of one or more types of target item in a medical image (e.g. cancer screening). To understand and improve how radiologists do such tasks, it must be understood how the human &apos;search engine&apos; works. This article briefly reviews some of the relevant work into this aspect of medical image perception. Questions include how attention and the eyes are guided in radiologic search? How is global (image-wide) information used in search? How might properties of human vision and human cognition lead to errors in radiologic search? (authors)

  11. MID-INFRARED HIGH-CONTRAST IMAGING OF HD 114174 B: AN APPARENT AGE DISCREPANCY IN A &apos;'SIRIUS-LIKE'&apos; BINARY SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Christopher T.; Crepp, Justin R. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Skemer, Andrew; Hinz, Philip M.; Bailey, Vanessa P.; Defrere, Denis; Leisenring, Jarron [Department of Astronomy, University of Arizona, 993 N. Cherry Ave, Tucson, AZ 85721 (United States); Gianninas, Alexandros; Kilic, Mukremin [Department of Physics and Astronomy, University of Oklahoma, Norman, OK 73019 (United States); Skrutskie, Michael [Department of Astronomy, University of Virginia, Charlottesville, VA 22904 (United States); Esposito, Simone; Puglisi, Alfio [Istituto Nazionale di Astrofisica, Osservatorio Astrofisico di Arcetri Largo E. Fermi I-550125 Firenze (Italy)

    2014-03-10

    We present new observations of the faint &apos;'Sirius-like'&apos; companion discovered to orbit HD 114174. Previous attempts to image HD 114174 B at mid-infrared wavelengths using NIRC2 at Keck have resulted in a non-detection. Our new L&apos;-band observations taken with the Large Binocular Telescope and L/M-band InfraRed Camera recover the companion (ΔL = 10.15 ± 0.15 mag, ρ = 0.&apos;&apos;675 ± 0.&apos;&apos;016) with a high signal-to-noise ratio (10σ). This measurement represents the deepest L&apos; high-contrast imaging detection at subarcsecond separations to date, including extrasolar planets. We confirm that HD 114174 B has near-infrared colors consistent with the interpretation of a cool white dwarf (WD; J – L&apos; = 0.76 ± 0.19 mag, K – L&apos; = 0.64 ± 0.20). New model fits to the object&apos;s spectral energy distribution indicate a temperature T {sub eff} = 4260 ± 360 K, surface gravity log g = 7.94 ± 0.03, a cooling age t{sub c} ≈ 7.8 Gyr, and mass M = 0.54 ± 0.01 M {sub ☉}. We find that the cooling ages given by theoretical atmospheric models do not agree with the age of HD 114174 A derived from both isochronological and gyrochronological analyses. We speculate on possible scenarios to explain the apparent age discrepancy between the primary and secondary. HD 114174 B is a nearby benchmark WD that will ultimately enable a dynamical mass estimate through continued Doppler and astrometric monitoring. Efforts to characterize its physical properties in detail will test theoretical atmospheric models and improve our understanding of WD evolution, cooling, and progenitor masses.

  12. PHS terminal &apos;TEGACKY&apos; dedicated to e-mailing; Mail senyo PHS tanmatsu &apos;TEGACKY

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The e-mail utilization rate at mobile communication terminals is increasing at a remarkable rate, as if to grow above the rate of communication by voice. Under the circumstances, a PHS (Personal Handyphone System) terminal &apos;TEGACKY&apos; (type name: PM-T101) has been developed, designed exclusively for use for e-mailing. &apos;TEGACKY&apos; is characterized in that its icons may be activated with pen, that input may be made by handwriting, and that its large screen allows a 48-character message consisting of 4 lines of 12 characters to be displayed at one time despite its compact size. It can also perform communication directly with other terminals or e-mail via center, and is provided with an information service function. &apos;TEGACKY&apos; having such distinguished features has created a new category of terminals which are at once e-mailing tools. (translated by NEDO)

  13. The importance of making right knowledge about radiation popular. Activity of &apos;radiation education forum&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Matsuura, Tatsuo; Iiri, Yuichi [Radiation Education Forum, Tokyo (Japan)

    2000-05-01

    Radiation and radionuclides are not only indispensable in medical diagnoses and treatments, but are widely used in fundamental researches in various fields and in industry, thus contribute much to humans for elevating the quality of life. Nuclear power production is also playing an important role in saving the nonrenewable natural energy resources, without producing potentially problematic carbon dioxide. However, a majority of people has an excessive concern for radiation and radioactivity even for very minute quantities. This is due to the following three facts: (1) the first use of nuclear energy as the disastrous weapon in 1945 has resulted a profound after-effect in socio-psychological sense especially in Japan, (2) the major accidents of nuclear power plants which occurred in 1980&apos;s have been repeatedly reported in mass media with undue sensationalism, and (3) the proposition, that every ray of ionizing radiation may destroy DNA of human cells and is harmful by bringing carcinogenic or hereditary effects, has fixed as a suspicion-free common sense for general public. This proposition has its basis on the recommendation by ICRP of adopting the LNT (linear non-threshold), model even for low dose of radiations comparative with the natural radiation level. Thus the majority of people shows the syndrome of radio phobia&apos;. Because there are so many risks other than radiation in the present day civilization, the extremely severe regulation only of radiation has many social demerits, and it is highly necessary that this situation be improved, by making the correct scientific information popular to the public. As an approach to this goal, a voluntary group, &apos;Radiation Education Forum&apos;, comprised of scientists, schoolteachers, journalists and citizens, has been established in 1994 in Japan, and has continued various types of activities. Because the social education has its basis on the school education, we have focussed our energy mainly for

  14. Ionizing radiation: down regulation of &apos;atm&apos; by 2 Deoxy-D-Glucose: a dose and time dependent study

    International Nuclear Information System (INIS)

    Lahiri, S.S.; Saxena, N.; Hambarde, S.

    2014-01-01

    Exposure to Ionizing Radiation (IR) cause cell death, but it also help in radio-sensitization of cancer cells, by causing oxidative stress and DNA damage, primarily by double strand breaks. Ataxia telangiectasia mutated (atm) gene is involved in DNA double strand breaks, sensory and repair pathways. Therefore, inhibition of its expression, can lead to useful radio-sensitization of cancerous cells. Metabolic inhibitor 2-Deoxy-D-Glucose (2-DG) block glycolysis and modulates protein glycosylation (2-DG). This cause sensitization of cancer cells to radiation, which help in effective reduction in the essential dose of therapeutic ionizing radiation required for the treatment of cancer. The transcription factor Sp-1 involved, is also down-regulated by 2-DG. We have studied the effect of 2-DG at varied concentrations, applied at different pre, simultaneous as well as post irradiation time intervals with 2 Gy, 5 Gy or 10 Gy (lethal dose) of ionizing radiations. Expressions of &apos;atm&apos; gene in response to the drug and/or IR of different doses were studied. Response was studied at different post irradiation time intervals, in the levels of mRNA, protein and cell survival. It was observed that exposure of human glioma cells (BMG1) to 2 Gy, 5 Gy or 10 Gy of IR alone, had differential and dose dependent effect on &apos;atm&apos; expression. The &apos;atm&apos; level was significantly down regulated by 2-DG, in non-irradiated as well as gamma ray irradiated cells. It was observed that BMG1 cells when treated with 2-DG and exposed to irradiation, there was no net significant alteration (normalcy was restored) in the expression level of &apos;atm&apos;. It was also observed that the extent of down-regulation by pre-treatment with 2-DG, was greater than post-treatment. This work has great significance in the application of clinically relevant low dose radiotherapy for the treatment of cancer. (author)

  15. Environmental pollution in Piracicaba Basin, Minas Gerais state, &apos;steel valley&apos;, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Queiroz, Marluce Teixeira Andrade; Veado, Maria Adelaide R.V. [Centro Universitario do Leste de Minas Gerais (UNILESTE-MG), Coronel Fabriciano, MG (Brazil)]. E-mails: mariavasc@unilestemg.br; marluce.queiroz@yahoo.com.br; Menezes, Maria Angela de B.C.; Amaral, Maria Angela [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)]. E-mail: menezes@cdtn.br

    2007-07-01

    Total heavy metal and trace elements concentrations were evaluated in smelting waste areas, in Piracicaba River, Minas Gerais, Brazil. The studies samples were surface water, border sediment, and fish muscle (Acara - Geophagus Brasiliensis). Elevated concentrations were found in Acara muscle fish As (1.3 - 1.8 {mu}g g{sup -1}), Hg (0.7 - 1.84 {mu}g g{sup -1}), Cr (0.7 - 4.1 {mu}g g{sup -1}), Zn ( 43 - 76 {mu}g g{sup -1}); in sediment Fe (81996 - 461147 {mu}g g{sup -1}), Cr (126 - 447 {mu}g g{sup -1}), Co ( 540 - 1016 {mu}g g{sup -1}), Th (7.9 - 50 {mu}g g{sup -1}). For the water samples the similar high heavy metal concentrations of Al, As, Cr, Fe, and Zn in all sampling sites were above the maximum limits permitted by Brazilian Environmental Council. The high level of heavy metals can affect the aquatic and cattle animals and human health. To conclusion the region studied in Piracicaba River in Minas Gerais State, Brazil, is not in agreement with the environmental parameters for &apos;water class 3&apos; according to Resolution by Brazilian Environmental Standards (CONAMA). An urgent program of measures for assessment and monitoring is necessary in this River. (author)

  16. Analysis of &apos;&apos;new physics&apos;&apos; in the flavor sector using effective field theory methods

    Energy Technology Data Exchange (ETDEWEB)

    Dassinger, Benjamin M.

    2010-02-05

    The enormous amount of data collected by the B factories as well as the perspective concerning the upcoming experiments at the LHC provide us with the opportunity to perform high precision tests of the standard model. This dissertation presents two model independent precision tests of the weak sector of the standard model using extensions of the weak currents which are set up using effective field theory methods in order to control the size of the different contributions. Constraints on the coefficients of the terms can then be obtained by comparison with experimental results. The first analysis incorporates a test of the lefthandedness of the weak interaction in the quark sector. By introducing additional weak couplings the differential and total decay rates of the inclusive semileptonic decay anti B {yields} X{sub c}l anti {nu}{sub l} are calculated. The calculation includes the computation of the heavy-quark expansion which describes the interaction of the decaying b quark with respect to the background field of the B meson, up to order 1/m{sub b}{sup 4}. This has been done in a new, systematic way which does not involve the calculation of gluon matrix elements. Furthermore, radiative corrections have been included up to order O({alpha}{sub s}) including renormalization group running. The second part deals with the introduction of lepton flavor violating operators in the context of leptonic {tau} decays. These operators give rise to the effective four-fermion vertex {tau}{yields}ll{sup &apos;}l'&apos; as well as the subsequent radiative decay {tau}{yields}l{gamma}{sup *}{yields}ll{sup &apos;+}l{sup &apos;-}. The resulting Dalitz distributions turn out to predict completely different signatures for the radiative and the effective four-fermion vertices and provide the opportunity to check, whether the decay is induced either by a radiative or by an effective four-fermion vertex. Since different models which contain lepton flavor violation are normally more

  17. The clock face guide to peroneal intraneural ganglia: critical &apos;'times'&apos; and sites for accurate diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Spinner, Robert J. [Mayo Clinic, Department of Neurologic Surgery, Rochester, MN (United States); Mayo Clinic, Department of Orthopedics, Rochester, MN (United States); Mayo Clinic, Department of Anatomy, Rochester, MN (United States); Luthra, Gauri [University College Cork, National University of Ireland, Cork (Ireland); Desy, Nicholas M. [McGill University School of Medicine, Department of Orthopedics, Montreal, Quebec (Canada); Anderson, Meredith L. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Amrami, Kimberly K. [Mayo Clinic, Department of Neurologic Surgery, Rochester, MN (United States); Mayo Clinic, Department of Radiology, Rochester, MN (United States)

    2008-12-15

    The aim of this study is to exploit the normal nature of peroneal nerve anatomy to identify constant magnetic resonance imaging (MRI) patterns in peroneal intraneural ganglia. This study is designed as a retrospective clinical study. MR images of 25 patients with peroneal intraneural ganglia were analyzed and were compared to those of 25 patients with extraneural ganglia and 25 individuals with normal knees. All specimens were interpreted as left-sided. Using conventional axial images, the position of the common peroneal nerve and either intraneural or extraneural cyst was determined relative to the proximal fibula and the superior tibiofibular joint using a symbolic clock face. In all patients, the common peroneal nerve could be seen between the 4 and 5 o&apos;clock position at the mid-portion of the fibular head. In patients with intraneural ganglia, a single axial image could reproducibly and reliably demonstrate both cyst within the common peroneal nerve at the mid-portion of the fibular head (signet ring sign) between 4 and 5 o&apos;clock and within the articular branch at the superior tibiofibular joint connection (tail sign) between 11 and 12 o&apos;clock; in addition, cyst within the transverse limb of the articular branch (transverse limb sign) was seen at the mid-portion of the fibular neck between the 12 and 2 o&apos;clock positions on serial images. Extraneural ganglia typically arose from more superior joint connections with the epicenter of the cyst varying around the entire clock face without a consistent pattern. There was no significant difference between the visual and template assessment of clock face position for all three groups (intraneural, extraneural, and controls). We believe that the normal anatomic and pathologic relationships of the common peroneal nerve in the vicinity of the fibular neck/head region can be established readily and reliably on single axial images. This technique can provide radiologists and surgeons with rapid and

  18. Change of radiation conditions at the &apos;'Ukryttya&apos; object after pitching of arch construction

    International Nuclear Information System (INIS)

    Jegorov, V.V.; Morozov, Yu.V.; Pavlovs'kij, L.Yi.; Kholodyuk, A.O.

    2017-01-01

    Individual measurements of dose rate (DR) capacity values were performed on the outer surfaces (roof) of object &apos;'Ukryttya'&apos;, in local zone both before and after pitching of Arch construction (Arch) as well as study the characteristics of angular distribution of gamma radiation intensity at those areas. A comparative analysis of results obtained was performed. At all measuring points after Arch pitching a reduction of DR value, depending on area of research, was observed.Measurements were being performed during the period from 16.11.2016 till 18.01.2017

  19. ANDRA&apos;s news; L&apos;actualite de l&apos;Andra

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This press kit presents the three missions of the French national agency of radioactive wastes (ANDRA) and the main highlights of these three missions for the second half of 2003: 1 - industrial mission: the very low radioactive waste disposal facility of Morvilliers (543 m{sup 3} of waste packages already stored), the Aube disposal facility (exploitation data), the Manche disposal facility (adaptation to new monitoring standards); 2 - the research mission: the Meuse/Haute-Marne laboratory (progress of works and experimental program), the mobilization of competences (international expertise of ANDRA&apos;s researches about deep underground disposal, the coordination of the European program ESDRED); 3 - the information mission: national inventory of radioactive wastes, publications and events, recall of ANDRA&apos;s missions. (J.S.)

  20. What is &apos;&apos;good technology&apos;&apos;? On the heuristic competence of the engineer; &apos;&apos;Was ist eine &apos;'gute'&apos; Technologie? Zur heuristischen Kompetenz des Ingenieurs

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, H.G. [Erlangen-Nuernberg Univ. (Germany). Inst. fuer Systematische Theologie

    1999-07-01

    This paper is intended to contribute to the discourse of this book both in a direct and indirect way, in so far as the paper can be searched for the aspects and insight brought in from the perspective of the humanities, and what impact these may have on innovative processes for technological progress. The author refers for instance to aspects of ethics that go beyond the existing concept of ethics of technology, and also refer to the connection between ethics and aesthetics, so as to maintain a wider view encompassing the latter aspects. (orig./CB) [German] Der folgende Beitrag will zum Gesamtthema nicht nur direkt, sondern auch indirekt etwas beitragen, sofern er daraufhin befragt werden kann, was durch eine geisteswissenschaftliche Perspektive ins Spiel kommt und was sich daraus fuer die Innovation von technologischen Entwicklungen ergeben koennte. Dabei ist generell wichtig, dass nicht nur interdisziplinaere Kooperationen (wie zwischen Techniksoziologie und Technologie) eine Rolle spielen, sondern auch das Herausarbeiten bestimmter Aufgaben, die quer zu den Faechern oder Wissenschaftszweigen verlaufen. Das betrifft beispielsweise Aspekte der Ethik, die ueber das hinausgehen, was als Ethik der Technik bisher konzipiert worden ist. Das betrifft auch den Zusammenhang von Ethik und Aesthetik. Dafuer sollte der Blick offen bleiben. (orig.)

  1. Active pollution reduction in the &apos;off-road&apos; sector. Proceedings; Aktive Schadstoffminderung im &apos;Off-road&apos; Bereich. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The state of the art and trends in off-gas purification and filters were gone into. The focus was on technical aspects, performance information and cost of diesel engines with high-efficiency exhaust purification systems as well as on sulfur-free fuels. [German] Mit der Tagung &apos;Aktive Schadstoffminderung im &apos;'Off-road'&apos; Bereich&apos; bieten wir eine besondere Gelegenheit zur Information und Auseinandersetzung mit dem derzeitigen Stand und den Entwicklungsperspektiven der Abgasreinigung und Filtertechnik bei Neubeschaffungen und in der Nachruestung. Gerade in staedtischen Ballungsgebieten, aber auch in geschlossenen Raeumen und Produktionshallen sind die Reduzierung der lokalen Emissionen und Vermeidung von Geruchsbelaestigungen unabdingbar. Im Mittelpunkt stehen Technik, Betriebserfahrungen und Kosten von Dieselmotoren mit hocheffizienter Abgasreinigung sowie schwefelfreie Kraftstoffe. (orig.)

  2. Energy at the man service: typology and size scales; L&apos;energie au service de l&apos;homme: typologie et ordres de grandeurs

    Energy Technology Data Exchange (ETDEWEB)

    Combarnous, M. [Bordeaux-1 Univ., Lab. Energetique et Phenomenes de Transfert, UMR CNRS, ENSAM, 33 - Talence (France)

    2005-07-01

    This analysis is made in an anthropic prospect way: all energy considerations are directed by the utilization of the energy forms used by human populations. This leads necessarily to favour fluxes or energy stocks which are not a priori the most important in the system. For instance, the energy stock represented by the Earth with respect to a body having the same mass at ambient temperature is not considered. On the contrary, the energy fluxes corresponding to terrestrial vegetal biomass, and in particular those mobilized for alimentary purposes, have to be considered. This document presents: the evolution and heterogeneity of human populations (demography, gross domestic product), the energy units and its equivalents, the Earth&apos;s surface - atmosphere system (solar radiation, hydric statuses, carbon cycle and fluxes), the world energy consumption and its trends, the main &apos;explicit&apos; consumptions (fossil fuels, nuclear energy, hydroelectric power), the different energy forms used by men and the share of renewable energy sources, the &apos;implicit&apos; solar energy consumptions (biomass), the complexity of energy chains and the savings that can be inferred from. (J.S.)

  3. &apos;&apos;Wie alles sich zum Ganzen webt&apos;&apos;: on a new orientation for the concept of matter, based on relations between quantum physics and cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Goernitz, T. [Inst. fuer Didaktik der Physik, J.W.Goethe-Univ., Frankfurt/Main (Germany)

    2007-07-01

    It is common sense between physicists that in the beginning the cosmos is in a narrow relationship to quantum phenomena. Because of the universal validity of quantum theory this relation remains significant in the whole cosmic evolution. Whereas a classical approach is sufficient for the description of many phenomena it is no more useful at last for the case of the ground state of a system. This holds also for the cosmos. The black holes are that part of physics where quantum theory and gravitational theory come into close contact. There a Gedankenexperiment becomes possible that clarifies the fundamental role of abstract quantum information. We give it a new name (Protyposis) because it must be imagined without emitter, receiver and moreover without any concrete meaning. This meaning-free abstract quantum information is defined by means of black holes and cosmology. Protyposis enables a new conception for &apos;'matter'&apos; and makes possible to overcome the problems of the &apos;'Lego-world-view'&apos;, which result from the attempt to find the &apos;&apos;simple and therefore basic concepts&apos;&apos; in the range of spatial smallness. Matter can be understood now as &apos;&apos;formed and condensed quantum information&apos;&apos;. But on a first view it is nothing to see from its character of being information, as like matter does not appear as &apos;&apos;pure motion&apos;&apos;, what it is also because of E=mc{sup 2}. (orig.)

  4. What does &apos;nuclear power village&apos; represent in the newspaper articles?

    Energy Technology Data Exchange (ETDEWEB)

    Takenaka, I., E-mail: isshin.takenaka@gmail.com [The Univ. of Tokyo, Tokyo (Japan); Kimura, H., E-mail: kimura.hiroshi.0110@gmail.com [Public Outreach, Non-Profit, Tokyo (Japan)

    2014-07-01

    Since the Fukushima Daiichi Nuclear Disaster in 2011, we have often heard the word &apos;Nuclear Power Village (Genshiryoku-Mura in Japanese)&apos; in Japan. &apos;Nuclear Power Village&apos; is used for the Japanese community related to nuclear power generation. In this paper, we analysed Japanese newspapers and clarified usages of &apos;Nuclear Power Village&apos;. As a result, we found there are two images of &apos;Nuclear Power Village&apos;. One image has a common purpose of the promotion of nuclear power. Another image has a common purpose of acquiring gain. We also clarified the characteristics of the images such as interdependence, closed community and so on. (author)

  5. Safety requirements expected to the prototype fast breeder reactor &apos;Monju&apos;

    International Nuclear Information System (INIS)

    2014-11-01

    In July 2013, Nuclear Regulation Authority (NRA) has enforced new regulatory requirements in consideration of severe accidents for the commercial light water reactors (LWR) and also prototype power generation reactors such as the sodium-cooled fast reactors (SFR) of &apos;Monju&apos; based on TEPCO Fukushima Daiichi nuclear power plant accident (hereinafter referred to as &apos;1F accident&apos;) occurred in March 2011. Although the regulatory requirements for SFR will be revised by NRA with consideration for public comments, Japan Atomic Energy Agency (JAEA) set up &apos;Advisory Committee on Monju Safety Requirements&apos; consisting of fast breeder reactor (FBR) and safety assessment experts in order to establish original safety requirements expected to the prototype FBR &apos;Monju&apos; considering severe accidents with knowledge from JAEA as well as scientific and technical insights from the experts. This report summarizes the safety requirements expected to Monju discussed by the committee. (author)

  6. The Palestinian Authority and &apos;Climate Change&apos; as an Emergent Public Problem

    International Nuclear Information System (INIS)

    Fustec, Klervi

    2014-01-01

    &apos;Climate change&apos; is an oft avowed environmental priority among cooperation and development actors. The Palestinian Territories, for their part, are one of the largest recipients of international aid. To the degree that the UNPD has played a role in promoting the question of &apos;climate change&apos;, the dependence of the Palestinian Authority on international aid has contributed to framing this emergent public problem; its construction is anchored in the context of the Israeli-Palestinian conflict and the Palestinian state&apos;s demand for recognition at the international level. In the international arenas dedicated to &apos;climate change&apos;, what&apos;s more, the Palestinian Authority discusses this question in terms of political and climatic injustice. Two questions thus merit study: what effect does the construction of the climate problem have on the Palestinian Authority and, conversely, what effect does the Palestinian Authority have on the construction of the climate problem?

  7. Those who &apos;Cry Wolf&apos; about nuclear safety damage their own credibility

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Redditch (United Kingdom)

    2016-06-15

    Do you recall the fable of the boy who cried wolf? I was reminded of this following the latest call by Germany&apos;s Federal Environment Minister, Barbara Hendricks, for Belgium to take two of its nuclear reactors off the grid, citing &apos;'questions'&apos; about the units&apos; safety. Those in positions of power and influence in one country should take care to be as responsible in their dealings with their neighbours as they are in handling domestic matters of state. Those who see &apos;danger&apos; where there is none are not being good neighbours. They are generating fear and alarm without good cause and should mind their own business.

  8. What does &apos;nuclear power village&apos; represent in the newspaper articles?

    International Nuclear Information System (INIS)

    Takenaka, I.; Kimura, H.

    2014-01-01

    Since the Fukushima Daiichi Nuclear Disaster in 2011, we have often heard the word &apos;Nuclear Power Village (Genshiryoku-Mura in Japanese)&apos; in Japan. &apos;Nuclear Power Village&apos; is used for the Japanese community related to nuclear power generation. In this paper, we analysed Japanese newspapers and clarified usages of &apos;Nuclear Power Village&apos;. As a result, we found there are two images of &apos;Nuclear Power Village&apos;. One image has a common purpose of the promotion of nuclear power. Another image has a common purpose of acquiring gain. We also clarified the characteristics of the images such as interdependence, closed community and so on. (author)

  9. Bookshelf (John R. Huizenga, &apos;Cold Fusion: the Scientific Fiasco of the Century&apos;)

    International Nuclear Information System (INIS)

    Morrison, Douglas R.O.

    1994-01-01

    &apos;&apos;Cold fusion is dead, isn&apos;t it?&apos;&apos; is a question I am often asked. The reply is a strange one, &apos;&apos;Yes, scientifically it is dead, but not from a media point of view or from funding&apos;&apos; In 1989 two electrochemists, Martin Fleischmann and Stanley Pons, claimed sustained nuclear fusion had been achieved in a test-tube with a palladium cathode and deuterium, observing excess heat, neutrons and tritium. A series of encouraging confirmations and successively greater excess heat claims were seized on by the world&apos;s media. The US Government set up a panel of some 20 world-class scientists from several disciplines under John Huizenga, distinguished professor of Chemistry and Physics at the University of Rochester. They concluded that there was no present evidence for the discovery of a new nuclear process termed cold fusion. It might be thought that would end cold fusion, but for interesting reasons, it did not entirely. John Huizenga has written a book describing the curious claims and evidence for cold fusion and has given an excellent explanation of the science involved. This was published as a hardback book of 236 pages, telling the story up to the end of June 1990. Again one might think it was the end of the cold fusion story. Now he has written about what happened in the next two years in a paperback book which contains an epilogue of 51 pages. If you thought the first year was extraordinary, the next two years described in the new edition were even more incredible! In the main part of the book, the basic science is simply and clearly explained. The number of &apos;'miracles'&apos; required for each results or theory is described - a &apos;'miracle'&apos; is a gross violation of previous knowledge and experimental results such as energy conservation. Thus some theories are classified as &apos;&apos;triple miracles&apos;&apos;. It might be thought that people who claimed to have observed cold fusion

  10. The superlative in front of the British coast. Offshore wind park &apos;&apos;London Array&apos;&apos;; Der Superlativ vor der britischen Kueste. Offshore-Windpark &apos;&apos;London Array&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rechenbach, Baerbel

    2012-07-01

    Fossil energy is finite and is getting more expensive. In order to develop alternative energy sources, technical solutions are becoming increasingly complex. Such technical solutions usually are implementable in international cooperation. German engineering know-how is in high demand, such as the construction of the world&apos;s largest offshore wind farm London Array. This project arises 24 km east of the British coasts of Essex and Kent in the estuary of the Thames. The project cost amounts approximately 400 million Euro.

  11. OJT. make &apos;em or break &apos;em

    Energy Technology Data Exchange (ETDEWEB)

    Arner, S.A.

    1992-01-01

    On-the-job training (OJT) has been with us in varying forms for longer than perhaps any other type of training. In reality, OJT is a process for accomplishing change; change in an employee&apos;s ability to perform assigned job duties. However, bringing about that change can often be a difficult process. A clear understanding of what change really is and what it entails is essential to easing its process. this document discusses the methodology in OJT and emphasizes the importance of communications in this process.

  12. &apos;Lifecycle cost&apos; management used in ITER project

    International Nuclear Information System (INIS)

    Xing Chao; Wu Fengfeng

    2013-01-01

    &apos;Lifecycle cost&apos; management is a new kind of management. The International Nuclear Fusion Energy Program was managing by &apos;lifecycle cost&apos; method. The cost and other factors associated with cost were under control by the method. In the future, the system engineering method should be focused in engineering management, paying equal attention to both evaluation and management, and strengthening the application of information system in the cost management to effectively improve the management level. (authors)

  13. Experiences from the exercise &apos;'MERLIN'&apos; for the detection of radioactive substances with the participation of special-purpose vehicles; Erfahrungen aus der Uebung &apos;'MERLIN'&apos; zur Detektion radioaktiver Stoffe unter Beteiligung verschiedenen Einsatzfahrzeuge

    Energy Technology Data Exchange (ETDEWEB)

    Griesbach, M. [Hessisches Ministerium des Innern und fuer Sport, Wiesbaden (Germany)

    2009-08-15

    Experiences of an exercise with hazardous goods, in particular with radioactive substances (measurements and taking environmental samples) are described. Several special-purpose vehicles with equipment and specially trained crews were used together with radiation protection experts according to the concept of Hesse. It has been the greatest exercise in Hesse with regard to hazardous goods and in particular with regard to &apos;&apos;incidents with radioactive substances&apos;&apos;. (orig.)

  14. Green economy. From theory to practice; &apos;Green Economy&apos;. Von der Theorie zur Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Wackerbauer, Johann [ifo Institut, Muenchen (Germany)

    2013-04-15

    The topic of &apos;&apos;green economy&apos;&apos; took centre stage at last year&apos;s UN conference on sustainable development in Rio de Janeiro. The term &apos;&apos;green economy&apos;&apos; has many interpretations to it, ranging from an emphasis on energy and resource efficiency in an otherwise ordinary economy to positions that are critical of growth as such. What can be considered as the essence of the concept of green economy, and what challenges need to be mastered on the way there? The present study shows that there is more to the term than most companies and consumers are aware of.