Contributions to a Marxist Critical Pedagogy: Revisiting Marx's Humanism

Science.gov (United States)

Malott, Curry

2014-01-01

In this essay Malott makes a case for a Marxist-informed critical pedagogy situating Marx's approach to Hegelian dialectics at the center. After reviewing Marx's critique of Hegel in his 1844 manuscripts, Malott outlines Marx's shifting conception of the falling rate of profit reflecting his developing understanding of what the…

''As a German citizen, I am curious as to how grid stability will be maintained''

Energy Technology Data Exchange (ETDEWEB)

Mitev, Lubomir [NucNet, Brussels (Belgium)

2015-10-15

With Germany pushing ahead with plans to phase out nuclear energy by 2020, Ralf Gueldner, president of the German Atomic Forum, talks to NucNet about the future of nuclear, continuing efforts to open a high-level waste repository, and potential economic problems caused by high levels of uncertainty in the country's power market.

Ultrasonographic median nerve cross-section areas measured by 8-point 'inching test' for idiopathic carpal tunnel syndrome: a correlation of nerve conduction study severity and duration of clinical symptoms

International Nuclear Information System (INIS)

Chen, Shu-Fang; Lu, Cheng-Hsien; Huang, Chi-Ren; Chuang, Yao-Chung; Tsai, Nai-Wen; Chang, Chiung-Chih; Chang, Wen-Neng

2011-01-01

Incremental palmar stimulation of the median nerve sensory conduction at the wrist, the 'inching test', provides an assessment with reference to segments proximal and distal to the entrapment. This study used high-resolution ultrasonography (US) to measure the median nerve's cross-section areas (CSAs) like the 'inching test' and to correlate with the nerve conduction study (NCS) severity and duration of carpal tunnel syndrome (CTS). Two hundred and twelve (212) 'CTS-hands' from 135 CTS patients and 50 asymptomatic hands ('A-hands') from 25 control individuals were enrolled. The median nerve CSAs were measured at the 8-point marked as i4, i3, i2, i1, w, o1, o2, and 03 in inching test. The NCS severities were classified into six groups based on motor and sensory responses (i.e., negative, minimal, mild, moderate, severe, and extreme). Results of US studies were compared in terms of NCS severity and duration of clinical CTS symptoms. There was significantly larger CSA of the NCS negative group of 'CTS-hands' than of 'A-hands'. The cut-off values of the CSAs of the NCS negative CTS group were 12.5 mm 2 , 11.5 mm 2 and 10.1 mm 2 at the inlet, wrist crease, and outlet, respectively. Of the 212 'CTS-hands', 32 were NCS negative while 40 had minimal, 43 mild, 85 moderate, 10 severe, and two extreme NCS severities. The CSAs of 'CTS-hands' positively correlated with different NCS severities and with the duration of CTS symptoms. By duration of clinical symptoms, 12 of the 212 'CTS-hands' were in the 1 month group; 82 in >1 month and ≤12 months group, and 118 in >12 months group. In 'inching test', segments i4-i3 and i3-i2 were the most common 'positive-site'. The corresponding CSAs measured at i4 and i3, but not at i2, were significantly larger than those measured at points that were not 'positive-site'. Using the 8-point measurement of the median

The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles

DEFF Research Database (Denmark)

Christoffersen, Christina; Benn, Marianne; Christensen, Pernille Møller

2012-01-01

.005) of the initial amounts of human apoM remained in the plasma of Wt and LDL receptor-deficient mice, respectively. Finally, we compared the turnover of radio-iodinated LDL and plasma apoM concentrations in 45 normocholesterolemic humans. There was a negative correlation between plasma apoM and the fractional......ApoM is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL receptor deficiency is associated with increased plasma apoM in mice. Here, we tested the idea that plasma apoM concentrations...... = 0.02, respectively) as compared with noncarriers (0.93 ± 0.04 µM). When we injected human apoM-containing HDL into Wt (n = 6) or LDL receptor-deficient mice (n = 6), the removal of HDL-associated human apoM was delayed in the LDL receptor-deficient mice. After 2 h, 54 ± 5% versus 90 ± 8% (P

ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression

DEFF Research Database (Denmark)

Burillo, Elena; Lindholt, Jes S.; Molina-Sánchez, Pedro

2015-01-01

proteomic analysis of plasma proteins was performed in AAA patients at different stages of evolution [small AAA (aortic size=3-5 cm) vs large AAA] using iTRAQ labelling, high-throughput nano-LC-MS/MS and a novel multi-layered statistical model. Among the proteins identified, ApoA-I was decreased in patients...... with large AAA compared to those with small AAA. These results were validated by ELISA on plasma samples from small (n=90) and large AAA (n=26) patients (150± 3 vs 133± 5 mg/dl, respectively, plevels strongly correlated with HDL-Cholesterol (HDL-C) concentration (r=0.9, p....89± 2.99 vs 1.59± 5.74 mmol/l, plevels are negatively associated with AAA evolution. Therapies targeting...

'Mote' networks; A nano SWAT team for the oilpatch

Energy Technology Data Exchange (ETDEWEB)

Ross, E.

2004-05-01

'Motes' are tiny sensor modules which make up wireless sensor networks for monitoring parameters such as energy use or temperature. Motes have the capacity for self-configuring a network, self-correct without downtime if there is an interruption in the connection, and for transferring information using the fastest and most reliable path in sending data to the control system via a gateway. Dust Incorporated, a technology company based in Berkeley, California, employs motes to communicate with each other in a self-healing, self-organizing way, and to do so at the lowest possible cost. At present, motes are used mainly in defence and industrial monitoring applications, however the company is exploring potential applications in the oilpatch in facilities that include pumping stations, pipelines, or remote areas, unattended for long periods of time. Application in perimeter security systems is also being explored. Key to the technology is the concept of mesh networks: i.e. instead of each mote having a single channel back to a backbone, the system has multiple paths, able to find another path if one route fails. In the oil and gas industry one of the most promising applications so far has been use as a 'rapid profiling kit' in which the network could be used to augment rough measurements with measurements of a higher resolution. Another application contemplated is use of mote networks in monitoring the health of machines by 'listening for crunching or knocking'. Low power requirement is the key to success in wireless systems; accordingly, Dust Corporation's objective is to perfect the timing and radio transmission rates to the point where the modules can operate for five to ten years on two 'AA' batteries.

The energy consumption of traffic 1990 - 2035 - Results of scenarios I - IV; Der Energieverbrauch des Verkehrs 1990 - 2035. Ergebnisse der Szenarien I bis IV und der zugehoerigen Sensitivitaeten 'BIP hoch', 'Preise hoch' und 'Klima waermer'

Energy Technology Data Exchange (ETDEWEB)

Keller, M.

2007-07-01

This comprehensive report for the Swiss Federal Office of Energy (SFOE) presents four scenarios concerning the development of energy consumption in the traffic sector for the period 1990 - 2035. The four scenarios - status quo, increased co-operation between the state and the economy with various energy levies, global reduction of energy consumption and, finally, scenario IV 'on the way to a 2000-Watt Society' - are briefly described. The areas examined include road, rail and air traffic as well as 'off-road' traffic. Infrastructure developments are commented on. The four scenarios are examined for various sensitivities including high gross domestic product GDP, high prices and warmer climate. Alternative fuels are looked at, as are further factors such as fuel tourism, pollutant emissions and costs. The results of the sensitivity analyses are compared and discussed and the necessary instruments are examined. This comprehensive report is completed with a comprehensive appendix

The Relationship between Human Operators' Psycho-physiological Condition and Human Errors in Nuclear Power Plants

Energy Technology Data Exchange (ETDEWEB)

Kim, Arryum; Jang, Inseok; Kang, Hyungook; Seong, Poonghyun [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

2013-05-15

The safe operation of nuclear power plants (NPPs) is substantially dependent on the performance of the human operators who operate the systems. In this environment, human errors caused by inappropriate performance of operator have been considered to be critical since it may lead serious problems in the safety-critical plants. In order to provide meaningful insights to prevent human errors and enhance the human performance, operators' physiological conditions such as stress and workload have been investigated. Physiological measurements were considered as reliable tools to assess the stress and workload. T. Q. Tran et al. and J. B. Brooking et al pointed out that operators' workload can be assessed using eye tracking, galvanic skin response, electroencephalograms (EEGs), heart rate, respiration and other measurements. The purpose of this study is to investigate the effect of the human operators' tense level and knowledge level to the number of human errors. For this study, the experiments were conducted in the mimic of the main control rooms (MCR) in NPP. It utilized the compact nuclear simulator (CNS) which is modeled based on the three loop Pressurized Water Reactor, 993MWe, Kori unit 3 and 4 in Korea and the subjects were asked to follow the tasks described in the emergency operating procedures (EOP). During the simulation, three kinds of physiological measurement were utilized; Electrocardiogram (ECG), EEG and nose temperature. Also, subjects were divided into three groups based on their knowledge of the plant operation. The result shows that subjects who are tense make fewer errors. In addition, subjects who are in higher knowledge level tend to be tense and make fewer errors. For the ECG data, subjects who make fewer human errors tend to be located in higher tense level area of high SNS activity and low PSNS activity. The results of EEG data are also similar to ECG result. Beta power ratio of subjects who make fewer errors was higher. Since beta

Methodology for calibration of detector of NaI (TI)) 3 ' X 3 ' for in vivo measurements of patients with hyperthyroidism undergoing to radioiodotherapy; Metodologia para calibracao de detector de NaI(TI) ) 3'X3' para medicoes in vivo em pacientes portadores de hipertireoidismo submetidos a radioiodoterapia

Energy Technology Data Exchange (ETDEWEB)

Carvalho, Carlaine B.; Lacerda, Isabelle V.B.; Oliveira, Mercia L.; Hazin, Clovis A., E-mail: carlaine.carvalho@gmail.com, E-mail: bellelacerda@hotmail.com, E-mail: mercial@cnen.gov.br, E-mail: chazin@cnen.gov.br [Universidade Federal de Pernambuco (DEN/UFPE), Recife, PE (Brazil). Departamento de Energia Nuclear; Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil); Lima, Fabiana F., E-mail: fflima@cnen.gov.br [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil)

2013-10-01

The aim of this study is to establish the methodology for calibration of the detection system to be used in determining the therapeutic activity of {sup 131}I required to release desired absorbed dose in the thyroid gland . This step is critical to the development of a protocol for individualized doses. The system consists of a detector of NaI (Tl ) 3'x3' coupled to software Genie 2000. We used the calibration sources of {sup 60}Co , {sup 137}Cs and {sup 133}Ba. We obtained the straight calibration system, with sources {sup 60}Co and {sup 137}Cs. Subsequently , the detector was calibrated using a thyroid phantom-neck designed and produced by the IRD / CNEN with known activity of {sup 133}Ba standard solution containing 18.7 kBq (on 09/24/12) evenly distributed. He was also calibrated with other thyroid- neck phantom model 3108 manufactured by Searle Radigraphics Ind., containing a liquid source of {sup 131}I ( 7.7 MBq ). Five measurements were performed during 5 minutes for three different distances detector-simulator and calculated the corresponding calibration factors . The values of the calibration factors found for the simulator made by IRD and Searle Radigraphics Ind. for the distances 20, 25 and 30 cm were 0.35 , 0.24, 0.18, 0.15 , 0.11, 0, 09 , respectively. With the detection system properly calibrated and the calibration factors established, the technique is suitable for the evaluation of diagnostic activities of {sup 131}I incorporated by hyperthyroid patients. (author)

Physical human-robot interaction of an active pelvis orthosis: toward ergonomic assessment of wearable robots.

Science.gov (United States)

d'Elia, Nicolò; Vanetti, Federica; Cempini, Marco; Pasquini, Guido; Parri, Andrea; Rabuffetti, Marco; Ferrarin, Maurizio; Molino Lova, Raffaele; Vitiello, Nicola

2017-04-14

In human-centered robotics, exoskeletons are becoming relevant for addressing needs in the healthcare and industrial domains. Owing to their close interaction with the user, the safety and ergonomics of these systems are critical design features that require systematic evaluation methodologies. Proper transfer of mechanical power requires optimal tuning of the kinematic coupling between the robotic and anatomical joint rotation axes. We present the methods and results of an experimental evaluation of the physical interaction with an active pelvis orthosis (APO). This device was designed to effectively assist in hip flexion-extension during locomotion with a minimum impact on the physiological human kinematics, owing to a set of passive degrees of freedom for self-alignment of the human and robotic hip flexion-extension axes. Five healthy volunteers walked on a treadmill at different speeds without and with the APO under different levels of assistance. The user-APO physical interaction was evaluated in terms of: (i) the deviation of human lower-limb joint kinematics when wearing the APO with respect to the physiological behavior (i.e., without the APO); (ii) relative displacements between the APO orthotic shells and the corresponding body segments; and (iii) the discrepancy between the kinematics of the APO and the wearer's hip joints. The results show: (i) negligible interference of the APO in human kinematics under all the experimented conditions; (ii) small (i.e., ergonomics assessment of wearable robots.

Bookshelf (''Neutrons, Nuclei and Matter'', by J. Byrne)

International Nuclear Information System (INIS)

Hansen, P.G.

1994-01-01

Time was when a neophyte wanting to do experiments with neutrons would be told first to read D.J. Hughes' classic ''Pile Neutron Research'' (1952). The book by J. Byrne is in many respects a modern equivalent, although if you were to send your student away with it, you will risk not seeing him or her again for a considerable time. What is immediately striking is that the book, rich in information and quite long, is cross-disciplinary and touches essentially all the main areas of modern physics. It covers parts of particle physics, such as the internal structure of the neutron, time-reversal violation as revealed by the (still hypothetical) electric dipole moment of the neutron, and the coupling constants for the weak interaction. From the field of basic quantum physics there are chapters on neutron optics, wave phenomena with neutrons and on the applications of these in solid-state physics. Other chapters again delve deeply into nuclear structure, nuclear reaction theory, as well as their applications: nuclear reactors and nuclear energy. At a time with specialization rampant and many physicists tending to believe that venturing outside their own cloisters is uninteresting and even dangerous, it is a pleasure to come across a book that is basically just about physics. J. Byrne of Sussex has for long been active in neutron research at the British-French-German Institut Laue-Langevin (ILL) research reactor in Grenoble, where he has worked on subjects such as weak interactions and fundamental symmetries. He has clearly intended ''Neutrons, Nuclei and Matter'' as a vade-mecum that will allow the practitioner to find the necessary information and formulas. But I believe that many others not directly engaged in neutron research will gain new insight from its many examples. To take just one case, I had not been aware of the simple physical principles that permit cold neutrons to be stored in a bottle. (The main point is that a

Radioimmunoassay of apolipoprotein A-I of rat serum

International Nuclear Information System (INIS)

Fainaru, M.; Havel, R.J.; Felker, T.E.

1976-01-01

A double antibody radioimmunoassay technique was developed for quantification of apolipoprotein A-I, the major apoprotein of rat high density lipoprotein. Apo A-I was labelled with 125 I by the chloramine-T method. 125 I-labeled apo A-I had the same electrophoretic mobility as unlabeled apo A-I and more than 80% of the 125 I was precipitated by rabbit anti apo A-I antibodies. The assay is sensitive at the level of 0.5-5 ng, and has intraassay and interassay coefficients of variation of 4.5 and 6.5% respectively. The specificity of the assay was established by competitive displacement of 125 I-labeled apo A-I from its antibody by apo A-I and lipoproteins containing apo A-I, but not by rat albumin and other apoproteins. Immunoreactivity of high density lipoprotein and serum was only about 35% of that of their delipidated forms when Veronal buffer was used as a diluent. Inclusion of 5 mM sodium decyl sulfate in the incubation mixture brought out reactivity equivalent to that found after delipidation. Completeness of the reaction was verified by comparison with the amount of apo A-I in chromatographic fractions of the total apoprotein of high density lipoprotein. Content (weight %, mean values +- S.D.) of immunoassayable apo A-I was: 62.3 +- 5.9 in high density lipoprotein; 1.7 +- 0.3 in low density lipoprotein; 0.09 +- 0.03 in very low density lipoprotein and 25.0 +- 5.0 in lymph chylomicrons. Concentration in whole serum was 51.4 +- 8.9 mg/dl and 33.6 +- 4.1 mg/dl for female and male rats, respectively (p 1.21 g/ml and <1% in lipoproteins of d<1.063 g/ml

How to recover credibility of nuclear technologies in Japan where people wish to have &apos;Anshin&apos;

International Nuclear Information System (INIS)

Yasui, Itaru

2014-01-01

Although it is inevitable to recover credibility of utilities, there are no clear ways to realize a final target yet. Credibility issue is a very difficult especially in Japan, where the word of &apos;Anshin&apos; has special importance in the mind of people. In this paper, the word of &apos;Anshin&apos; in Japan was discussed in order to find out differences in other countries by comparison of culture and customs, especially ways to prepare food, i.e. agriculture and hunting and gathering and so on. The meanings of &apos;Anshin&apos; were decomposed into several elements, and each element was discussed and clarified. Human factor is important in both operation of plants and risk communication. The philosophy and attitude of COE of utilities are those of very important factors to regain credibility. The utilities&apos; responsibilities are important, but not enough by themselves. In order to assure transparency of information used in risk communication, improvement of people&apos;s scientific literacy and their attitude to elect their representatives are absolutely necessary. Especially, risk information related to Level 3 RPA to be opened to public have to be fully transparent. Risk is one of most difficult concept for Japanese people to handle. The reoperation issue of nuclear power plants will involve several difficulties, but challenges to overcome this issue will be a good chance to change a way of decision making in Japan. (author)

&apos;Focal thyroid inferno&apos; on color Doppler ultrasonography: A specific feature of focal Hashimoto&apos;s thyroiditis

Energy Technology Data Exchange (ETDEWEB)

Fu, Xianshui, E-mail: fuxs1968@163.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Guo, Limei, E-mail: guolimei@bjmu.edu.cn [Department of Pathology, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Zhang, Huabin, E-mail: huabinzhang@bjmu.edu.cn [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Ran, Weiqiang, E-mail: ranwq-sina@vip.sina.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Fu, Peng, E-mail: fupeng01@gmail.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Li, Zhiqiang, E-mail: lizhq126@126.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Chen, Wen, E-mail: wendy7989@sina.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Jiang, Ling, E-mail: papayaling@yahoo.com.cn [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Wang, Jinrui, E-mail: jinrui_wang@sina.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Jia, Jianwen, E-mail: drjia88@sohu.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China)

2012-11-15

Purpose: To evaluate color-Doppler features predictive of focal Hashimoto&apos;s thyroiditis. Materials and methods: A total of 521 patients with 561 thyroid nodules that underwent surgeries or gun biopsies were included in this study. These nodules were divided into three groups: focal Hashimoto&apos;s thyroiditis (104 nodules in 101 patients), benignity other than focal Hashimoto&apos;s thyroiditis (73 nodules in 70 patients), and malignancy (358 nodules in 350 patients). On color Doppler sonography, four vascularity types were determined as: hypovascularity, marked internal flow, marked peripheral flow and focal thyroid inferno. The {chi}{sup 2} test was performed to seek the potential vascularity type with the predictive ability of certain thyroid pathology. Furthermore, the gray-scale features of each nodule were also studied. Results: The vascularity type I (hypovascularity) was more often seen in focal Hashimoto&apos;s thyroiditis than other benignity and malignancy (46% vs. 20.5% and 19%). While the type II (marked internal flow) showed the opposite tendency (26.9% [focal Hashimoto&apos;s thyroiditis] vs. 45.2% [other benignity] and 52.8% [malignancy]). However, type III (marked peripheral flow) was unable to predict any thyroid pathology. Importantly, type IV (focal thyroid inferno) was exclusive to focal Hashimoto&apos;s thyroiditis. All 8 type IV nodules appeared to be solid, hypoechoic, and well-defined. Using &apos;focal thyroid inferno&apos; as an indicator of FHT, the diagnostic sensitivity and specificity were 7.7% and 100% respectively. Conclusions: The vascularity type of &apos;focal thyroid inferno&apos; is specific for focal Hashimoto thyroiditis. Recognition of this particular feature may avoid unnecessary interventional procedures for some solid hypoechoic thyroid nodules suspicious of malignancy.

Potential of polymeric materials for packaging; L&apos;impiego dei materiali polimerici nell&apos;imballaggio

Energy Technology Data Exchange (ETDEWEB)

Lanchi, M. [ENEA, Divisione Nuovi Materiali, Centro Ricerche Casaccia, Rome (Italy)

2001-07-01

;ambito della produzione, l&apos;industria italiana del packaging si colloca tra i settori piu&apos; efficienti e competitivi. Per quanto riguarda i campi di utilizzo, la destinazione degli imballaggi e&apos; principalmente verso il settore alimentare, che da solo copre una quota di circa il 42%, mentre, considerando anche il comparto delle bevande, tale quota sale al 65%. Le materie plastiche vengono largamente impiegate in questo settore, grazie alla proprieta&apos; molto diversificate: leggerezza, inerzia e resistenza alla corrosione, facile formabilita&apos;, buona trasparenza, capacita&apos; di attenuazione delle vibrazioni meccaniche e sonore, elevata conservabilita&apos; nel tempo, elevate caratteristiche dielettriche, ecc. I numerosi metodi di trasformazione attualmente in uso e le diverse tecniche di lavorazione dei materiali polimerici consentono di ottenere i prodotti estremamente variegati. Restringendo il campo di interesse al settore agroalimentare, fortemente sviluppato nel sud-italia, si possono individuare numerose prospettive di crescita per i polimeri utilizzati nell&apos;imballaggio: sviluppo di films polimerici a bassa permeabilita&apos; e ad alta selettivita&apos;; sviluppo della tecnologia dell&apos;atmosfera modificata; sviluppo di films polimerici attivi quali i films antimicrobici o i films trasferitori di odore e di colore. Altra linea di ricerca promettente e&apos; lo sviluppo di imballaggi in plastica ecocompatibili mediante la produzione di materiali ad alte prestazioni specifiche che riducano i volumi dei rifiuti e agevolino le operazioni di smaltimento, e/o la realizzazione di confezioni alimentari in materiale il piu&apos; possibile biodegradabile, attraverso il ricorso a blend di plastiche e polimeri bioderivati.

Drinking water pollution and risks for human health; Inquinamento dell&apos;acqua potabile e rischi per la salute

Energy Technology Data Exchange (ETDEWEB)

Bressa, G. [Padua Univ., Padua (Italy). Dipt. di Farmacologia, Laboratorio di Tossicologia

1999-12-01

The hypothesis that most human tumors are caused by toxic substances found in the environment, and that their onset is therefore basically predictable, is earning wider and wider consent. The results of experimental studies carried out on animals have shown that some of the chemical pollutants found in drinking water possess cancerogenous activity. Their origin and can vary a lot because most public water supplies come from rivers, lakes, or from groundwater tables, and, therefore, contain pollutants from agricultural land waste water, from industrial waste and from deliberate or accidental inputs. As a consequence, this kind of pollution can involve some risks for human health as a result of both direct use of tainted water or indirect use through food. [Italian] Trova sempre piu&apos; consenso l&apos;ipotesi secondo cui la maggior parte dei tumori nell&apos;uomo sia prodotta da sostanze tossiche presenti nell&apos;ambiente e che quindi la loro insorgenza sia fondamentalmente prevenibile. Dalla vasta gamma di contaminati chimici identificabli nell&apos;acqua potabile e&apos; risultato, da studi sperimentali su animali, che alcuni possiedono attivita&apos; cancerogena. Essi possono avere provenienze diverse, in quanto la maggior parte dei rifornimenti idrici pubblici originano da fiumi, laghi o dalla falda freatica, portando con se&apos; inquinanti provenienti dalle acque reflue dei terreni agricoli, da rifiuti industriali e da immissioni deliberate o accidentali. Tale inquinamento di conseguenza puo&apos; comportare dei rischi per la salute umana sia in seguito al consumo diretto di acqua contaminata che indirettamente attraverso gli alimenti.

Anthropogenic pollutants affect ecosystem services of freshwater sediments. The need for a &apos;triad plus x&apos; approach

Energy Technology Data Exchange (ETDEWEB)

Gerbersdorf, Sabine Ulrike; Wieprecht, Silke [Stuttgart Univ. (Germany). Dept. of Hydraulic Engineering and Water Resources Management; Hollert, Henner; Brinkmann, Markus [RWTH Aachen Univ. (Germany). Dept. of Ecosystem Analysis; Schuettrumpf, Holger [RWTH Aachen Univ. (Germany). Inst. of Hydraulic Engineering and Water Resources Management; Manz, Werner [Koblenz-Landau Univ., Koblenz (Germany). Inst. for Integrated Natural Sciences

2011-09-15

Purpose: Freshwater sediments and their attached microbial communities (biofilms) are essential features of rivers and lakes, providing valuable ecosystem services such as nutrient recycling or self-purification which extend beyond the aquatic environment. Anthropogenic pollutants, whether from the industrial era or as a result of our contemporary lifestyles, can negatively affect these functions with hitherto unknown consequences on ecology, the economy and human health. Thus far, the singular view of the involved disciplines such as ecotoxicology, environmental microbiology, hydrology and geomorphology has prevented a deeper understanding of this emerging issue. Main features: This paper discusses briefly the progressions and the state-of-the-art methods within the disciplines of concern related to contaminated sediments, ranging from ecotoxicological test systems, microbiological/molecular approaches to unravel changes of microbial ecosystems, up to the modelling of sediment transport and sorption/desorption of associated pollutants. The first bilateral research efforts on contaminated sediments include efforts to assess ecotoxicological sediment risk including sediment mobility (i.e. ecotoxicology and engineering), enhance bioremediation potential (i.e. microbiology and ecotoxicology) or to understand biostabilisation processes of sediments by microbial assemblages (i.e. microbiology and engineering). Conclusions and perspectives: In freshwater habitats, acute, chronic and mechanism-specific toxic effects on organisms, shifts in composition, structure and functionality of benthic microbial communities, as well as the obstruction of important ecosystem services by continuously discharged and long-deposited pollutants, should be related to the in situ sediment dynamics. To achieve an improved understanding of the ecology of freshwater sediments and the impairment of their important ecosystem functions by human-derived pollutants, we suggest a &apos;triad plus x&apos

Hippocampal &apos;&apos;gliosis only&apos;&apos; on MR imaging represents a distinct entity in epilepsy patients

Energy Technology Data Exchange (ETDEWEB)

Hattingen, Elke; Enkirch, Simon Jonas; Jurcoane, Alina; Kruse, Maximilian [University Clinics Bonn, Neuroradiology, Department of Radiology, Bonn (Germany); Delev, Daniel [University Clinics Bonn, Department of Neurosurgery, Bonn (Germany); University Clinics Freiburg, Department of Neurosurgery, Freiburg (Germany); Grote, Alexander [University Clinics Bonn, Department of Neurosurgery, Bonn (Germany); Evangelic Hospital of Bethel, Department of Neurosurgery, Bielefeld (Germany); Becker, Albert [University Clinics Bonn, Institute of Neuropathology, Bonn (Germany)

2018-02-15

The purpose of this study is to evaluate whether patients with drug-resistant mesial temporal lobe epilepsy (TLE) due to hippocampal &apos;&apos;gliosis only&apos;&apos; have different MRI features than those with hippocampal sclerosis (HS). Most TLE patients have HS corresponding to severe neuronal loss and gliosis, but a few have &apos;&apos;gliosis only&apos;&apos; without significant reduction of neuronal density. We analyzed the morphology of cerebral 3 T MRIs (T1, T2, and FLAIR) of 103 patients with HS and 20 with &apos;&apos;gliosis only&apos;&apos; concerning hippocampal and amygdala aspect, volumes, and signal intensity (SI) using Fisher&apos;s exact test, Student&apos;s t test, and principal component analysis. Visually, the ipsilateral hippocampus was hyperintense in both groups, but SI was markedly increased in 74% of HS and in 25% of &apos;&apos;gliosis only&apos;&apos; patients; the ipsilateral hippocampus was smaller in 92% of HS and in 50% of &apos;&apos;gliosis only&apos;&apos; patients, and its internal architecture was lost in 57% of HS and 5% of &apos;&apos;gliosis only&apos;&apos; patients; the contralateral hippocampal SI was altered in 25% of HS and in 70% of &apos;&apos;gliosis only&apos;&apos; patients (all p < 0.001). Ipsilateral hippocampus of HS patients had lower volume (mean ± SD 2.86 ± 0.87 ml) compared with that of &apos;&apos;gliosis only&apos;&apos; patients (3.4 ± 1.02 ml) and had higher SI than the contralateral hippocampus of HS patients and then the hippocampus of &apos;&apos;gliosis only&apos;&apos; patients (all p < 0.01). &apos;&apos;Gliosis only&apos;&apos; has different MRI hippocampal characteristics than HS: less volume loss, less increase of the T2-w signal intensity, preservation of internal architecture, and more contralateral affection. (orig.)

Hippocampal &apos;&apos;gliosis only&apos;&apos; on MR imaging represents a distinct entity in epilepsy patients

International Nuclear Information System (INIS)

Hattingen, Elke; Enkirch, Simon Jonas; Jurcoane, Alina; Kruse, Maximilian; Delev, Daniel; Grote, Alexander; Becker, Albert

2018-01-01

The purpose of this study is to evaluate whether patients with drug-resistant mesial temporal lobe epilepsy (TLE) due to hippocampal &apos;&apos;gliosis only&apos;&apos; have different MRI features than those with hippocampal sclerosis (HS). Most TLE patients have HS corresponding to severe neuronal loss and gliosis, but a few have &apos;&apos;gliosis only&apos;&apos; without significant reduction of neuronal density. We analyzed the morphology of cerebral 3 T MRIs (T1, T2, and FLAIR) of 103 patients with HS and 20 with &apos;&apos;gliosis only&apos;&apos; concerning hippocampal and amygdala aspect, volumes, and signal intensity (SI) using Fisher&apos;s exact test, Student&apos;s t test, and principal component analysis. Visually, the ipsilateral hippocampus was hyperintense in both groups, but SI was markedly increased in 74% of HS and in 25% of &apos;&apos;gliosis only&apos;&apos; patients; the ipsilateral hippocampus was smaller in 92% of HS and in 50% of &apos;&apos;gliosis only&apos;&apos; patients, and its internal architecture was lost in 57% of HS and 5% of &apos;&apos;gliosis only&apos;&apos; patients; the contralateral hippocampal SI was altered in 25% of HS and in 70% of &apos;&apos;gliosis only&apos;&apos; patients (all p < 0.001). Ipsilateral hippocampus of HS patients had lower volume (mean ± SD 2.86 ± 0.87 ml) compared with that of &apos;&apos;gliosis only&apos;&apos; patients (3.4 ± 1.02 ml) and had higher SI than the contralateral hippocampus of HS patients and then the hippocampus of &apos;&apos;gliosis only&apos;&apos; patients (all p < 0.01). &apos;&apos;Gliosis only&apos;&apos; has different MRI hippocampal characteristics than HS: less volume loss, less increase of the T2-w signal intensity, preservation of internal architecture, and more contralateral affection. (orig.)

Plasma metabolism of apolipoprotein A-IV in humans

International Nuclear Information System (INIS)

Ghiselli, G.; Krishnan, S.; Beigel, Y.; Gotto, A.M. Jr.

1986-01-01

As assessed by molecular sieve chromatography and quantitation by a specific radioimmunoassay, apoA-IV is associated in plasma with the triglyceride-rich lipoproteins, to a high density lipoprotein (HDL) subfraction of smaller size than HDL3, and to the plasma lipoprotein-free fraction (LFF). In this study, the turnover of apoA-IV associated to the triglyceride-rich lipoproteins, HDL and LFF was investigated in vivo in normal volunteers. Human apoA-IV isolated from the thoracic duct lymph chylomicrons was radioiodinated and incubated with plasma withdrawn from normal volunteers after a fatty meal. Radioiodinated apoA-IV-labeled triglyceride-rich lipoproteins, HDL, and LFF were then isolated by chromatography on an AcA 34 column. Shortly after the injection of the radioiodinated apoA-IV-labeled triglyceride-rich lipoproteins, most of the radioactivity could be recovered in the HDL and LFF column fractions. On the other hand, when radioiodinated apoA-IV-labeled HDL or LFF were injected, the radioactivity remained with the originally injected fractions at all times. The residence time in plasma of 125 I-labeled apoA-IV, when injected in association with HDL or LFF, was 1.61 and 0.55 days, respectively. When 125 I-labeled apoA-IV was injected as a free protein, the radioactivity distributed rapidly among the three plasma pools in proportion to their mass. The overall fractional catabolic rate of apoA-IV in plasma was measured in the three normal subjects and averaged 1.56 pools per day. The mean degradation rate of apoA-IV was 8.69 mg/kg X day

Modelling the basic error tendencies of human operators

Energy Technology Data Exchange (ETDEWEB)

Reason, J.

1988-01-01

The paper outlines the primary structural features of human cognition: a limited, serial workspace interacting with a parallel distributed knowledge base. It is argued that the essential computational features of human cognition - to be captured by an adequate operator model - reside in the mechanisms by which stored knowledge structures are selected and brought into play. Two such computational &apos;primitives&apos; are identified: similarity-matching and frequency-gambling. These two retrieval heuristics, it is argued, shape both the overall character of human performance (i.e. its heavy reliance on pattern-matching) and its basic error tendencies (&apos;strong-but-wrong&apos; responses, confirmation, similarity and frequency biases, and cognitive &apos;lock-up&apos;). The various features of human cognition are integrated with a dynamic operator model capable of being represented in software form. This computer model, when run repeatedly with a variety of problem configurations, should produce a distribution of behaviours which, in toto, simulate the general character of operator performance.

Serum 3,3&apos;-L-diiodothyronine, a direct radioimmunoassay in human serum: method and clinical results. [/sup 125/I tracer technique

Energy Technology Data Exchange (ETDEWEB)

Burger, A.; Sakoloff, C.

1977-09-01

A specific radioimmunoassay for 3,3&apos;-diiodothyronine (T/sub 2/) is described which is capable of detecting as little as 1.3 ng/dl. The antiserum recognizes mainly T/sub 2/; biliary conjugates of T/sub 2/ bind slightly to the antibody. The intraassay and interassay coefficients of variation were, respectively, 5.7% and 13.1%. T/sub 2/ was detected in the serum of hypothyroid patients treated with triiodothyronine (T/sub 3/) and in euthyroid subjects treated with reverse triiodothyronine (rT/sub 3/). These results suggest that both T/sub 3/ and rT/sub 3/ are deiodinated to T/sub 2/. Serum concentrations of T/sub 2/ in normal subjects decreased with age. Between 20 and 40 years the mean concentration was 4.3 +- 2.0 ng/dl (2 SD), between 41 and 60 years it varied from 1.9 to 5.8 ng/dl (3.8 +- 0.3 ng/dl, SE) and in elderly subjects have 60 years concentrations varied from unmeasurable to 4 ng/dl (2.9 +- 0.4 ng/dl, SE). Low serum T/sub 2/ concentrations were found in anorexia nervosa (2.5 +- 0.3 ng/dl, SE). In hypothyroidism the serum concentrations were low or unmeasurable. As most of the hypothyroid subjects were elderly their serum T/sub 2/ concentrations overlapped with the low values found in the elderly euthyroid subjects. In classical hyperthyroidism serum T/sub 2/ concentrations were greatly increased (3.3 to 31 ng/dl (11.8 +- 2.7 ng/dl, SE) but in &apos;&apos;T/sub 3/ toxicosis&apos;&apos; the concentrations were only modestly increased (2.4 to 8.8 ng/dl, 5.2 +- 0.8 ng/dl, SE).

Case story for upgrading of a &apos;'hot'&apos; ESP; Modernisation d&apos;un precipitateur electrostatique &apos;'chaud'&apos;

Energy Technology Data Exchange (ETDEWEB)

Chidambaram, T.V.S; Christensen

2001-06-01

The &apos;Hot&apos; Electrostatic Precipitator (ESP) equipped with COROMAX pulse system is a very attractive solution for dedusting of the &apos;Hot&apos; exhausted gases from the cement kilns especially on cement plants, where good quality of water is not available on the site. Furthermore, the Electrostatic Precipitator is still the preferred solution in the cement plants for dedusting the cement kiln. It is favored because of its high degree of reliability, its low power consumption, and its low maintenance cost. (author)

IDEA papers no 2; Les cahiers d&apos;I.D.E.A. n.2

Energy Technology Data Exchange (ETDEWEB)

Cassou, O

2002-09-01

The Information network on the Economic Development in Aquitaine (IDEA) aims to collect and spread the environmental information concerning the Aquitaine, in order to implement an observatory of the regional environment and of the sustainable development. The IDEA paper no. 2 is devoted to the IDEA missions and their cooperation with &apos;&apos;Alliance pour la qualite et la performance&apos;&apos;. This association groups actors for the development and the promotion of the quality. (A.L.B.)

Final state interactions in K → ππ decays: ΔI = 1/2 rule vs. ε{sup &apos;}/ε

Energy Technology Data Exchange (ETDEWEB)

Buras, Andrzej J. [TUM Institute for Advanced Study, Garching (Germany); TU Muenchen, Physik Department, Garching (Germany); Gerard, Jean-Marc [Universite catholique de Louvain, Centre for Cosmology, Particle Physics and Phenomenology (CP3), Louvain-la-Neuve (Belgium)

2017-01-15

Dispersive effects from strong ππ rescattering in the final state interaction (FSI) of weak K → ππ decays are revisited with the goal to have a global view on their relative importance for the ΔI = 1/2 rule and the ratio ε{sup &apos;}/ε in the standard model (SM). We point out that this goal cannot be reached within a pure effective (meson) field approach like chiral perturbation theory in which the dominant current-current operators governing the ΔI = 1/2 rule and the dominant density-density (four-quark) operators governing ε{sup &apos;}/ε cannot be disentangled from each other. But in the context of a dual QCD approach, which includes both long-distance dynamics and the UV completion, that is, QCD at short-distance scales, such a distinction is possible. We find then that beyond the strict large N limit, N being the number of colours, FSIs are likely to be important for the ΔI = 1/2 rule but much less relevant for ε{sup &apos;}/ε. The latter finding diminishes significantly hopes that improved calculations of ε{sup &apos;}/ε would bring its SM prediction to agree with the experimental data, opening thereby an arena for important new physics contributions to this ratio. (orig.)

Development and calibration of a portable detection system for in vivo monitoring of {sup 131}I incorporation by humans

Energy Technology Data Exchange (ETDEWEB)

Lucena, Eder A.; Dantas, Ana Leticia A.; Dantas, Bernardo M. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)], e-mail: eder@ird.gov.br

2009-07-01

{sup 131}I is one of the most frequently used radionuclides for diagnosis and therapy of thyroid diseases in nuclear medicine. Its increasing use for medical purposes creates a demand for feasible methodologies applied to the control of internal exposure by workers. In vivo monitoring of {sup 131}I incorporation is of great value for the evaluation of occupational exposure during its medical application and also in the case of accidents and incidents in nuclear power plants for the monitoring of workers and population. This work presents the development of a portable device specially designed for in vivo measurement of {sup 131}I in the thyroid. It is also presented the results of the calibration performed in different nuclear medicine centers where {sup 131}I is routinely manipulated for therapeutic purposes. The equipment consists in a NaI(Tl)3&apos;&apos;x3&apos;&apos; detector installed in a lead collimator and assembled on a tripod. The detection system was calibrated with the IRD-Neck-Thyroid phantom for the determination of the calibration factors for direct in vivo quantification of {sup 131}I in the thyroid. In order to evaluate the applicability and limitations of the system, committed effective doses associated to the minimum detectable activities were calculated using current biokinetic and dosimetric models available in the literature. Dose detection limits have shown to be far below 1 mSv for the most likely incorporation scenarios. (author)

Report of Activity, 1997; Rapport d&apos;activite, 1997

Energy Technology Data Exchange (ETDEWEB)

Lacoste, Andre-Claude; Livolant, Michel [eds.] [Inst. de Protection et de Surete Nucleaire, CEA Centre d' Etudes de Fontenay-aux-Roses, 92 (France)

1998-07-01

The Institute of Nuclear Protection and Safety (Institut de Protection et de Surete Nucleaire) - IPSN carries out research and expert studies needed in managing nuclear risk and consequences of nuclear events on population and environment, i.e. supervises the safety of installations, the prevention and study of accidents, the human health and environmental conditions, the safety of transport and has also the task of organizing the management of the crisis situations. IPSN has the mission of informing the public and participates in numerous international actions. Thus, since 1989 IPSN and its German counterpart, GRS, co-operate towards improving of the nuclear safety in Europe and developing a common approach of international issues. As acting for public authorities (government departments in charge with industry, environment, health or labor), IPSN grants technical authorizations on request of DSIN exploiters. The IPSN personnel amounts up to 1300 employees of whom around two thirds are engineers, researchers, physicians, agronomists, and veterinarians. This IPSN annual report contains in the &apos;Free Tribune&apos; section two general papers entitled: &apos;The federalist role of research at IPSN&apos; by Catherine Lecompte and &apos;The dose, a central issue in radioprotection debates&apos; by Annie Sugier. Then five sub-reports follow: 1.The safety of nuclear facilities and radioactive wastes; 2.Crisis management; 3. The management of sensitive materials (protection and control of sensitive materials and safety analysis of the radioactive materials transport); 4.Protection of human health; 5.Environment protection. The report also presents the international activities, the cooperation IPSN/GRS, the budget, the staff and the human resource policy and the communication activity.

A &apos;must-go path&apos; scenario for sustainable development and the role of nuclear energy in the 21st century

Energy Technology Data Exchange (ETDEWEB)

Jeong, Hae-Yong; Kim, Young-In; Lee, Yong-Bum; Ha, Kwi-Seok; Won, Byung-Chool; Lee, Dong-Uk; Hahn, Dohee [Korea Atomic Energy Research Institute, 1045 Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea)

2010-04-15

An increase in the world population has accelerated the consumption of fossil fuels and deepened the pollution of global environment. As a result of these human activities, it is now difficult to clearly guarantee the sustainable future of humankind. An intuitional &apos;must-go path&apos; scenario for the sustainable development of human civilization is proposed by extrapolating the human historical data over 30 years between 1970 and 2000. One of the most important parameters in order to realize the &apos;must-go path&apos; scenario is the sustainability of energy without further pollution. In some countries an expanded use of nuclear energy is advantageous to increase sustainability, but fast reactor technology and closed fuel cycle have to be introduced to make it sustainable. In other countries, the development of cost-effective renewable energy, and the clean use of coal and oil are urgently needed to reduce pollution. The effect of fast nuclear reactor technology on sustainability as an option for near-term energy source is detailed in this paper. More cooperation between countries and worldwide collaboration coordinated by international organizations are essential to make the &apos;must-go path&apos; scenario real in the upcoming 20 or 30 years. (author)

The positive impact of &apos;Luz do Campo&apos; program in a rural area: the sericulture in Ribeirao Claro, Parana, Brazil; O impacto positivo do programa &apos;Luz do campo&apos; na extensao rural: a sericicultura em Ribeirao Claro, Parana, Brazil

Energy Technology Data Exchange (ETDEWEB)

Carmo, Jose R. do; Marques, Rui Manuel B.S.; Betiol Junior, Genesio [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-Graduacao e Energia], e-mail: jrcarmo@iee.usp.br, e-mail: rmanuel@iee.usp.br, e-mail: genesio.betiol@poli.usp.br; Ribeiro, Fernando Selles [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica de Engenharia], e-mail: fribeiro@pea.usp.br

2004-07-01

The &apos;Luz do Campo&apos; program has created positive and favorable impact to the opening of opportunities in the rural area. It has contributed to facilitate the access of workers to energetic facilities and has contributed to providing them with better social and economical conditions. As a consequence after the accomplishment of the rural electrification process in the settlements of &apos;Anhumas&apos; and &apos;Maria Neto&apos; implanted in Ribeirao Claro in Parana, it was possible to come to terms with two projects of Sericiculture in that location. The energy consumption of these projects has not been only restricted to human comfort, but has also been aimed at the production. As a result, the economical success achieved in those settlements in less than a year&apos;s time, is due to the transformation actions in the countryside that have lowered poverty and raised the perspectives of better life quality to the settlers. (author)

Radiobiological study of the radioprotective activity of a natural Iranian compound, &apos;'Shir-Khecht'&apos;; Etude radiobiologique de l&apos;activite radioprotectrice d&apos;un compose naturel Iranien: le &apos;'Shir-Khecht'&apos;

Energy Technology Data Exchange (ETDEWEB)

Rouhanizadeh, N. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1968-01-01

After reviewing the primary mechanisms of the action of ionizing radiation, the possible mechanisms of the action of radioprotective substances, the various chemical structures having a protective effect and the methods for studying chemical radioprotection, the author presents the results he has obtained with natural Iranian product: &apos;'Shir-Khecht'&apos;. Tests with this product at lethal and sublethal doses have been carried out on the rat using various means of introduction. The effect of radiation, both with and without protection, has been studied using histological and biochemical methods. The product examined has, in effect, a protective action; it is, furthermore, non-toxic and active when taken orally. (author) [French] Apres avoir rappele les mecanismes primaires de l&apos;action des rayonnements ionisants, les mecanismes possibles de l&apos;action des substances radioprotectrices, les diverses structures chimiques possedant un effet protecteur et les methodes d&apos;etude de la radioprotection chimique, l&apos;auteur presente les resultats qu&apos;il a obtenus en utilisant un compose naturel iranien: le &apos;'Shir-Khecht'&apos;. Des essais de ce produit, chez le rat, par diverses voies d&apos;introduction, a dose letale et subletale ont ete effectues. L&apos;effet des radiations, avec et sans protection, a ete etudie a l&apos;aide de methodes histologiques et biochimiques. Le compose essaye possede un pouvoir protecteur; il est, de plus, non toxique et actif par voie orale. (auteur)

Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans

DEFF Research Database (Denmark)

Bagdade, John; Pedersen, Bente K; Schwenke, Dawn

2011-01-01

B:E) apoB-containing subclasses present in VLDL. Therefore, we have directly measured these subclasses following their isolation by sequential immunoprecipitation in seven healthy male subjects during a 3-h infusion with recombinant human (rh) IL-6. Though plasma TG and apoB-containing particle number were...... unchanged by IL-6, the distribution of TG-rich subclasses was significantly altered. Compared to baseline values, LpB:E + LpB:C:E increased significantly at 0.5 h (p infused controls at 0.5 and 1 h (p

Synthesis and binding to striatal membranes of non carrier added I-123 labeled 4&apos;-iodococaine

Energy Technology Data Exchange (ETDEWEB)

Metwally, S.A.M.; Gatley, S.J.; Wolf, A.P.; Yu, D.-W. (Brookhaven National Lab., Upton, NY (United States))

1992-03-01

An {sup 123}I labeled cocaine analog, 4&apos;-({sup 123}I)iodococaine, has been prepared by oxidative destannylation of the tributyltin analog and shown to interact with cocaine binding sites in rat brain striatal membranes. It may thus be a suitable SPECT radiotracer for studies of the dopamine reuptake site in neurodegenerative diseases. (Author).

I-tese newsletter - Number 13 - Summer 2011; La lettre de l&apos;I-tese - Numero 13 - Ete 2011

Energy Technology Data Exchange (ETDEWEB)

Popiolek, Nathalie; Devezeaux, Jean-Guy; Bernard, Herve; Behar, Christophe; Birraux, Claude; Cesarsky, Catherine; Sabourin, Didier; Imbach, Juliette; Le Duigou, Alain

2011-07-01

The first part of this issue reports a meeting (the third I-tese Day which took place in June 2011), the theme of which was the way to boost innovation towards a less carbonated economy, or how to pass from fundamental science to the market. Several topics have been addressed: the definition, nature and impacts of innovation, innovation in the field of energy (role of public authorities, of the relationship between actors, and of education). The texts of some contributions are proposed. They dealt with the CEA&apos;s contribution to innovation in the field of energy, with management as a tool to promote innovation, with innovation challenging fears and risks, with the role of research, with the way I-tese takes innovation into account in its research activities, with a competitive analysis of the biomass-to-liquid sector, with the application of real options theory to the R and D investment for tomorrow&apos;s nuclear, with the relationship between technical innovation and social acceptability (in the case of hydrogen within the AIDHY project). Then, articles discuss a macro-economic theoretical approach of R and D subsidies for de-carbonated energetic technologies, and the end of the HyFrance project for the development of hydrogen markets

Narratives as an educational tool : a review of &apos;A Scientific Romance&apos;

Energy Technology Data Exchange (ETDEWEB)

Hughes, J.; Andrey, J. [Waterloo Univ., ON (Canada). Dept. of Geography

2000-06-01

This paper examined how the use of narratives can be used as a tool for educating the public on climate change with particular reference to Ronald Wright&apos;s 1997 novel entitled A Scientific Romance. The novel develops climate change as a central theme in the development plot and has received excellent reviews from literary critics in Canada, Great Britain and the United States. This paper reviewed the novel using criteria from both cognitive psychology and climatology. Cognitive theory claims that human beings think, perceive, understand and make choices according to narrative structures. This evaluation compared Wright&apos;s depiction of future climate change with scientific projections. Wright provides great detail regarding climatic conditions of the Great London-Thames Estuary region of Southern England in the years 2500-2501. The climatic variables used in the evaluation consist of surface temperature, sea level rise, precipitation and wind speed. This evaluation determined that Wright&apos;s narrative depiction of London&apos;s future climate is much more extreme than what scientists project. It was concluded that Wright&apos;s tightly woven narrative takes an abstract issue and successfully transforms it into something interesting and provides a detailed depiction of a plausible future climate and its implications for society. However, two minor weaknesses were found to exist. First, there is little reference to the major cause of climate change, and secondly, the climate scenario depicted in the novel is more consistent with the runaway greenhouse theory than with scientists&apos; projections. It was cautioned that narratives must be used carefully and responsibly otherwise, the magnitude of portrayed changes may create a sense of disbelief or helplessness on the part of the public. 27 refs., 1 tab.

Trimethylsilylcyclopentadienyl (cp{sup &apos;}) uranium chemistry. Synthetic and structural studies of Cp{sup &apos;}{sub 4}U and Cp{sup &apos;}{sub 3}UX (X = Cl, I, Me)

Energy Technology Data Exchange (ETDEWEB)

Windorff, Cory J.; MacDonald, Matthew R.; Ziller, Joseph W.; Evans, William J. [Department of Chemistry, University of California, Irvine, CA (United States)

2017-12-13

Cp{sup &apos;}{sub 4}U (Cp{sup &apos;} = C{sub 5}H{sub 4}SiMe{sub 3}) was synthesized from: (a) KCp{sup &apos;} and [Cp{sup &apos;}{sub 3}U(THF)][BPh{sub 4}]; (b) Cp{sup &apos;}{sub 3}U and Cp{sup &apos;}{sub 2}Pb; and (c) [K(2.2.2-cryptand)][Cp{sup &apos;}{sub 4}U] and AgBPh{sub 4}. The compound was identified by X-ray crystallography as a rare example of a structurally-characterized tetrakis(cyclopentadienyl)U{sup IV} complex. For comparison, the corresponding Th complex, Cp{sup &apos;}{sub 4}Th, was isolated from the direct combination of ThBr{sub 4}(THF){sub 4} with excess KCp{sup &apos;}. During the preparation of Cp{sup &apos;}{sub 3}UMe, the precursor of the [Cp{sup &apos;}{sub 3}U(THF)][BPh{sub 4}] reagent used above, it was discovered that the reaction of Cp{sup &apos;}{sub 3}UCl and MeLi gives a mixture of Cp{sup &apos;}{sub 3}UMe and Cp{sup &apos;}{sub 3}UCl that can co-crystallize better than Cp{sup &apos;}{sub 3}UMe in pure form. The Cp&apos;{sub 3}UMe/Cp{sup &apos;}{sub 3}UCl mixture forms single crystals suitable for X-ray crystallography and provides a new way to characterize the oil, Cp{sup &apos;}{sub 3}UMe. Cp{sup &apos;}{sub 3}UCl and Cp{sup &apos;}{sub 3}UI were also crystallographically characterized for comparison with the Cp{sup &apos;}{sub 3}UMe/Cp{sup &apos;}{sub 3}UCl crystals. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Large-scale offshore wind farms in Denmark. Update of &apos;&apos;Future offshore sites for wind turbines 2025&apos;&apos;; Stor-skala havmoelleparker i Danmark. Opdatering af fremtidens havmoelleplaceringer

Energy Technology Data Exchange (ETDEWEB)

2011-04-15

This updating of the &apos;&apos;Future offshore sites for wind turbines 2025&apos;&apos;, is made by the Offshore Wind Farm Committee and adjusts primarily the existing sites in relation to a updated data basis. The sites are adjusted within the already identified areas, and no new areas are therefore included. In addition to an update of the underlying data base, including the revised sailing routes, the new Natura 2000 sites and mineral resources, there are now further collected knowledge about the seabed in the designated areas. Moreover, the underlying assumptions for construction costs and grid connection updated, which has resulted in a revised socio-economic priority of the areas. The Offshore Wind Farm Committee&apos;s report confirms that the placement of the 600 MW Kriegers Flak Offshore Wind Farm in the Baltic Sea is the best location for Denmark&apos;s next major offshore wind farm. Kriegers Flak Offshore Wind Farm is already included in the Government&apos;s energy strategy. (LN)

Synthesis of (+-)-(1,1&apos;- sup 15 N sub 2 , 2&apos;- sup 13 C)-trans-3&apos;-methylnicotine

Energy Technology Data Exchange (ETDEWEB)

Sirimanne, S.R.; Maggio, V.L.; Patterson, D.G. Jr. (Department of Health and Human Services, Atlanta, GA (United States))

1992-03-01

The synthesis of ({+-})- (1,1&apos;-{sup 15}N{sub 2}, 2&apos;-{sup 13}C)-trans-3&apos;-methylnicotine is reported. {sup 15}N-3-Bromopyridine obtained from bromination of pyridine was formylated with nBuLi/(carbonyl-{sup 13}C)-methyl formate. The resulting {sup 15}n-Pyridine-3-({sup 13}C-carbonyl)-carboxaldehyde was reacted with {sup 15}N-methylamine and then the resulting Schiff&apos;s base was condensed with succinic anhydride to give ({+-})- (1,1&apos;-{sup 15}N{sub 2}, 5&apos;-{sup 13}C)-trans-4&apos;-carboxycotinine. Reduction with lithium aluminum hydride and mesylation followed by reduction with Zn/NaI gave ({+-})-(1,1&apos;-{sup 15}N{sub 2}, 2&apos;-{sup 13}C)-trans-3&apos;-methylnicotine. (Author).

The strategic &apos;'pull'&apos; and operational &apos;'push'&apos; of total quality management in UK regional electricity service companies

Energy Technology Data Exchange (ETDEWEB)

McAdam, R.; McLean, J.; Henderson, J.

2003-04-30

The aim of this paper is to evaluate whether the UK regional electricity companies (RECs) has used total quality management (TQM) as a &apos;'push'&apos; or as a &apos;'pull'&apos; change methodology. &apos;'Push'&apos; is the operational improvement role of TQM; &apos;'pull'&apos; is the strategic or direction giving, improvement role of TQM. Following the onset of privatisation in 1990 there has been evidence of the RECs adopting TQM in both &apos;'push'&apos; and &apos;'pull'&apos; methodologies with varying degrees of success. An evaluation of the change processes involved will enable improved change models to be developed leading to increased business effectiveness in this 30 billion pounds sterling industry. Other possible benefits include the possible generalisations to other utilities such as water, roads, gas and telecoms. The research methodology includes a comparative case study analysis of five RECs, which have used TQM as their overarching approach to change. One of the cases is analysed to a more in-depth level based on the multiple case findings. The findings indicate that the &apos;'push-pull'&apos; analysis enables the full range of TQM activities to be evaluated in the RECs studied. Overall, there is a need to have a balanced portfolio of operational or &apos;'push'&apos;-based TQM activity that is driven by strategic or &apos;'pull'&apos; based TQM planning and activity. (author)

I&apos;m Not for Sale: Teaching about Human Trafficking

Science.gov (United States)

Moore, James

2018-01-01

Even though slavery is illegal in all countries, it is still practiced in the form of human trafficking. In fact, there are about twenty-five million men, women, and children who are victims of human trafficking, a 150-billion-dollar industry that affects every country across the globe. Modern communications, such as the Internet and cell phones,…

A highly luminescent dinuclear Eu(III) complex based on 4,4&apos;-bis (4&apos;&apos;,4&apos;&apos;,4&apos;&apos;-trifluoro-1&apos;&apos;,3&apos;&apos;-dioxobutyl)-o-terphenyl for light-emitting diodes

Energy Technology Data Exchange (ETDEWEB)

Liu Shenggui [State Key Laboratory of Optoelectronic Materials and Technologies, Ministry of Education Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China); School of Chemistry Science and Technology, Zhanjiang Normal University, New Materials Engineering and Technology Development Center of University in Guangdong, Zhanjiang 524048 (China); He Pei; Wang Huihui; Shi Jianxin [State Key Laboratory of Optoelectronic Materials and Technologies, Ministry of Education Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China); Gong Menglian, E-mail: cesgml@mail.sysu.edu.cn [State Key Laboratory of Optoelectronic Materials and Technologies, Ministry of Education Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China)

2009-08-15

A dinuclear Eu(III) complex Eu{sub 2}(btbt){sub 3}.4H{sub 2}O.CH{sub 3}CH{sub 2}OH.N(CH{sub 2}CH{sub 3}){sub 3} was synthesized, where H{sub 2}(btbt) was 4,4&apos;-bis (4&apos;&apos;,4&apos;&apos;,4&apos;&apos;,-trifluoro-1&apos;&apos;,3&apos;&apos;-dioxobutyl)-o-terphenyl. The composition and structure of the complex were characterized by elemental analysis, IR, UV-vis and FAB-MS spectroscopy. The complex emits the characteristic red luminescence of Eu{sup 3+} ion due to the {sup 5}D{sub 0} {yields} {sup 7}F{sub J} (J = 0-4) transitions under {approx}395 nm-light excitation with good luminescent quantum efficiency (32%) and exhibits high thermal stability (337 deg. C). Bright red light-emitting diodes (LEDs) were fabricated by coating the complex onto a {approx}395 nm-emitting InGaN chip. When the mass ratio of the red phosphor to the silicone is 1:30, the efficiency of the fabricated LEDs with the europium complex is 0.98 lm w{sup -1}. The CIE chromaticity coordinates of the LEDs are x = 0.6057 and y = 0.3137, which are close to the National Television Standard Committee (NTSC) standard values for red color. The results indicate that the complex may act as a red component in the fabrication of near UV InGaN-based white light-emitting diodes with high color-rendering index.

Design and implementation of a &apos;'cheese'&apos; phantom-based Tomotherapy TLD dose intercomparison

Energy Technology Data Exchange (ETDEWEB)

Schiefer, Hans; Buchauer, Konrad; Heinze, Simon [Medical Physics Group, Department of Radiation Oncology, St. Gallen (Switzerland); Henke, Guido; Plasswilm, Ludwig [Department of Radiation Oncology, St. Gallen (Switzerland)

2015-11-15

The unique beam-delivery technique of Tomotherapy machines (Accuray Inc., Sunnyvale, Calif.) necessitates tailored quality assurance. This requirement also applies to external dose intercomparisons. Therefore, the aim of the 2014 SSRMP (Swiss Society of Radiobiology and Medical Physics) dosimetry intercomparison was to compare two set-ups with different phantoms. A small cylindrical Perspex phantom, which is similar to the IROC phantom (Imaging and Radiation Oncology Core, Houston, Tex.), and the &apos;'cheese'&apos; phantom, which is provided by the Tomotherapy manufacturer to all institutions, were used. The standard calibration plans for the TomoHelical and TomoDirect irradiation techniques were applied. These plans are routinely used for dose output calibration in Tomotherapy institutions. We tested 20 Tomotherapy machines in Germany and Switzerland. The ratio of the measured (D{sub m}) to the calculated (D{sub c}) dose was assessed for both phantoms and irradiation techniques. The D{sub m}/D{sub c} distributions were determined to compare the suitability of the measurement set-ups investigated. The standard deviations of the TLD-measured (thermoluminescent dosimetry) D{sub m}/D{sub c} ratios for the &apos;'cheese'&apos; phantom were 1.9 % for the TomoHelical (19 measurements) and 1.2 % (11 measurements) for the TomoDirect irradiation techniques. The corresponding ratios for the Perspex phantom were 2.8 % (18 measurements) and 1.8 % (11 measurements). Compared with the Perspex phantom-based set-up, the &apos;'cheese'&apos; phantom-based set-up without individual planning was demonstrated to be more suitable for Tomotherapy dose checks. Future SSRMP dosimetry intercomparisons for Tomotherapy machines will therefore be based on the &apos;'cheese'&apos; phantom set-up. (orig.) [German] Die einzigartige Bestrahlungstechnik mit Tomotherapie-Bestrahlungsgeraeten (Accuray Inc., Sunnyvale, CA, USA) erfordert spezifische

Gunning for accuracy: Company targets human error with &apos;foolproof&apos; perforating gun

Energy Technology Data Exchange (ETDEWEB)

Ross, E.

2002-12-01

An innovative new design for a scalloped expandable perforating gun is described. The gun is manufactured in Edmonton by LRI Perforating Systems, and it aimed at reducing the chances of human error that can result in sub-optimal performance. A perforating gun is used to pierce the well&apos;s casing to allow hydrocarbons to flow into the wellbore. It consists of a carrier, a pipe with an eighth-inch thick wall that protects the explosives downhole, and an inner tube containing the explosives. The LRI system has a unique interlocking mechanism for the end plates, which are attached to either end of the thin-walled charge holder tube, in addition to other advantageous features, including a price advantage of 10 to 15 per cent. Marketing strategy is designed to interest wi reline companies that focus on vertical well applications. 1 photo.

Irradiation as a quarantine treatment of &apos;Carabao&apos; (&apos;Manila Super&apos;) mangoes

International Nuclear Information System (INIS)

Manoto, E.C.; Resilva, S.S.; Del Rosario, Ma.S.; Casubha, L.C.

1990-01-01

Researches using gamma radiation for disinfestation of Oriental fruit fly in &apos;Carabao&apos; (&apos;Manila Super&apos;) mangoes were undertaken using the Probit 9 or 99.9968% mortality test. The results showed that the mature larvae of the fruit fly are the most tolerant stage of this insect to irradiation with the eggs as the most sensitive. On treating more than 100,000 mature larvae in mangoes, a minimum dose of 100 Gy was found to prevent emergence of adult fruit flies and maintain quarantine security or a complete elimination of the possibility of introducing this pest into the importing country. Therefore, the use of 100-Gy irradiation as a quarantine treatment against Oriental fruit fly in the mature green Philippine &apos;carabao&apos; mango fruits is recommended

Characterization of lipoproteins in human and canine cerebrospinal fluid (CSF)

International Nuclear Information System (INIS)

Pitas, R.E.; Weisgraber, K.H.; Boyles, J.K.; Lee, S.; Mahley, R.W.

1986-01-01

Previously the authors demonstrated that rat brain astrocytes in vitro synthesize and secrete apo-E and possess apo-B,E(LDL) receptors. The apo-E secreted by astrocytes and apo-E in rat brain extracts differed from serum apo-E in two respects. Brain apo-E had a higher apparent molecular weight and a higher percentage of more acidic isoforms. To characterize further the apo-E within the central nervous system, apo-E in human and canine CSF was investigated. Compared to plasma apo-E, CSF apo-E had a higher apparent M/sub r/ and a higher percentage of acidic isoforms which were sialylated, as shown by neuraminidase digestion. The apo-E in human CSF was approx.5-10% of the plasma level. In CSF 60-80% of the apo-E was in lipoproteins with d = 1.09-1.15. The remainder of the apo-E was in the d > 1.21 fraction. Human CSF lipoproteins were primarily spherical (110-190 A) while canine CSF lipoproteins were a mixture of discs (205 x 65 A) while canine CSF lipoproteins were a mixture of discs (205 x 65 A) and spheres (100-150 A). The CSF also contained apo-AI in the d = 1.09-1.15 g/ml fraction. Human CSF lipoproteins containing both apo-E and apo-AI were isolated on an anti-apo-E affinity column, suggesting that apo-E and AI occurred in the same particles. The CSF apo-E-containing lipoproteins competed for binding of 125 I-LDL to the apo-B,E(LDL) receptor. There was no detectable apo-B in CSF. These data suggest that CSF lipoproteins might transport lipid and regulate lipid homeostasis within the brain

Caring about Strangers: A Lingisian Reading of Kafka&apos;s "Metamorphosis"

Science.gov (United States)

Hung, Ruyu

2013-01-01

This article explores a significant question, implicit in Kafka&apos;s novel "Metamorphosis," explicitly asked by Rorty: "Can I care about a stranger?" Alphonso Lingis&apos;s view is adopted to overcome a mainstream belief that there is a distinction between my community and the stranger&apos;s community, or us community and…

The H I chronicles of little things BCDs II: The origin of IC 10&apos;s H I structure

Energy Technology Data Exchange (ETDEWEB)

Ashley, Trisha; Simpson, Caroline E.; Pokhrel, Nau Raj [Department of Physics, Florida International University, 11200 SW 8th Street, CP 204, Miami, FL 33199 (United States); Elmegreen, Bruce G. [IBM T. J. Watson Research Center, PO Box 218, Yorktown Heights, New York 10598 (United States); Johnson, Megan [CSIRO Astronomy and Space Science P.O. Box 76, Epping, NSW 1710 Australia (Australia); Nidever, David L., E-mail: trisha.l.ashley@nasa.gov, E-mail: simpsonc@fiu.edu, E-mail: npokh001@fiu.edu, E-mail: bge@us.ibm.com, E-mail: megan.johnson@csiro.au, E-mail: dnidever@umich.edu [Department of Astronomy, University of Michigan Ann Arbor, MI, 48109 (United States)

2014-12-01

In this paper we analyze Very Large Array (VLA) telescope and Green Bank Telescope (GBT) atomic hydrogen (H I) data for the LITTLE THINGS (Local Irregulars That Trace Luminosity Extremes, The H I Nearby Galaxy Survey; https://science.nrao.edu/science/surveys/littlethings) blue compact dwarf galaxy IC 10. The VLA data allow us to study the detailed H I kinematics and morphology of IC 10 at high resolution while the GBT data allow us to search the surrounding area at high sensitivity for tenuous H I. IC 10&apos;s H I appears highly disturbed in both the VLA and GBT H I maps with a kinematically distinct northern H I extension, a kinematically distinct southern plume, and several spurs in the VLA data that do not follow the general kinematics of the main disk. We discuss three possible origins of its H I structure and kinematics in detail: a current interaction with a nearby companion, an advanced merger, and accretion of intergalactic medium. We find that IC 10 is most likely an advanced merger or a galaxy undergoing accretion.

The H I chronicles of little things BCDs II: The origin of IC 10&apos;s H I structure

International Nuclear Information System (INIS)

Ashley, Trisha; Simpson, Caroline E.; Pokhrel, Nau Raj; Elmegreen, Bruce G.; Johnson, Megan; Nidever, David L.

2014-01-01

In this paper we analyze Very Large Array (VLA) telescope and Green Bank Telescope (GBT) atomic hydrogen (H I) data for the LITTLE THINGS (Local Irregulars That Trace Luminosity Extremes, The H I Nearby Galaxy Survey; https://science.nrao.edu/science/surveys/littlethings) blue compact dwarf galaxy IC 10. The VLA data allow us to study the detailed H I kinematics and morphology of IC 10 at high resolution while the GBT data allow us to search the surrounding area at high sensitivity for tenuous H I. IC 10&apos;s H I appears highly disturbed in both the VLA and GBT H I maps with a kinematically distinct northern H I extension, a kinematically distinct southern plume, and several spurs in the VLA data that do not follow the general kinematics of the main disk. We discuss three possible origins of its H I structure and kinematics in detail: a current interaction with a nearby companion, an advanced merger, and accretion of intergalactic medium. We find that IC 10 is most likely an advanced merger or a galaxy undergoing accretion.

&apos;Carbon-Money Exchange&apos; to contain global warming and deforestation

Energy Technology Data Exchange (ETDEWEB)

Nagase, Kozo E-mail: nagase@de.mbn.or.jp

2005-07-01

This paper builds a basic theory of &apos;Carbon-Money Exchange&apos; in which carbon as currency in nature&apos;s household (ecosystems) and money as currency in humankind&apos;s household (economy) are exchanged just like in a foreign exchange. The simple chemical equation below makes it possible (CO{sub 2}{yields}C+O{sub 2}=C+O{sub 2}{yields}CO{sub 2}). The left-hand side represents the work of plants to remove atmospheric CO{sub 2}. The right-hand side represents the work of humans as fossil fuel consumers to produce it. The exchange of the two currencies is possible by copying the fossil fuel market. The paper concludes that this new exchange can automatically contain global warming and deforestation, replacing onerous emissions trading. Moreover, it could revolutionize the conventional economy, creating counter-capitalism, or &apos;carbonism&apos;.

PET imaging of HER1-expressing xenografts in mice with {sup 86}Y-CHX-A'&apos;-DTPA-cetuximab

Energy Technology Data Exchange (ETDEWEB)

Nayak, Tapan K.; Regino, Celeste A.S.; Milenic, Diane E.; Garmestani, Kayhan; Baidoo, Kwamena E.; Brechbiel, Martin W. [National Institutes of Health, Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD (United States); Wong, Karen J. [National Institutes of Health, Molecular Imaging Program, National Cancer Institute, Bethesda, MD (United States); Szajek, Lawrence P. [National Institutes of Health, PET Department, Warren G. Magnuson Clinical Center, Bethesda, MD (United States)

2010-07-15

Cetuximab is a recombinant, human/mouse chimeric IgG{sub 1} monoclonal antibody that binds to the epidermal growth factor receptor (EGFR/HER1). Cetuximab is approved for the treatment of patients with HER1-expressing metastatic colorectal cancer. Limitations in currently reported radiolabeled cetuximab for PET applications prompted the development of {sup 86}Y-CHX-A'&apos;-DTPA-cetuximab as an alternative for imaging HER1-expressing cancer. {sup 86}Y-CHX-A'&apos;-DTPA-cetuximab can also serve as a surrogate marker for {sup 90}Y therapy. Bifunctional chelate, CHX-A'&apos;-DTPA was conjugated to cetuximab and radiolabeled with {sup 86}Y. In vitro immunoreactivity was assessed in HER1-expressing A431 cells. In vivo biodistribution, PET imaging and noncompartmental pharmacokinetics were performed in mice bearing HER1-expressing human colorectal (LS-174T and HT29), prostate (PC-3 and DU145), ovarian (SKOV3) and pancreatic (SHAW) tumor xenografts. Receptor blockage was demonstrated by coinjection of either 0.1 or 0.2 mg cetuximab. {sup 86}Y-CHX-A'&apos;-DTPA-cetuximab was routinely prepared with a specific activity of 1.5-2 GBq/mg and in vitro cell-binding in the range 65-75%. Biodistribution and PET imaging studies demonstrated high HER1-specific tumor uptake of the radiotracer and clearance from nonspecific organs. In LS-174T tumor-bearing mice injected with {sup 86}Y-CHX-A'&apos;-DTPA-cetuximab alone, {sup 86}Y-CHX-A'&apos;-DTPA-cetuximab plus 0.1 mg cetuximab or 0.2 mg cetuximab, the tumor uptake values at 3 days were 29.3 {+-} 4.2, 10.4 {+-} 0.5 and 6.4 {+-} 0.3%ID/g, respectively, demonstrating dose-dependent blockage of the target. Tumors were clearly visualized 1 day after injecting 3.8-4.0 MBq {sup 86}Y-CHX-A'&apos;-DTPA-cetuximab. Quantitative PET revealed the highest tumor uptake in LS-174T (29.55 {+-} 2.67%ID/cm{sup 3}) and the lowest tumor uptake in PC-3 (15.92 {+-} 1.55%ID/cm{sup 3}) xenografts at 3 days after injection

Do we need a &apos;&apos;green medicine&apos;&apos;?; Brauchen wir &apos;&apos;Gruene Medizin?&apos;&apos;

Energy Technology Data Exchange (ETDEWEB)

Bauer, M.; Daschner, F.; Scherrer, M. [Universitaetsklinikum Freiburg (Germany)

2006-07-01

Spontaneously, we do associate &apos;&apos;green medicine&apos;&apos; with terms like naturopathy, natural healing substances, herbal active agents, homeopathy, healthy food, preventive medicine and similar things, and finally we think of ecology. This is the focus of the following article. First of all, the following question arises: Are there any environment-friendly and cost-saving alternatives to the present medicine? There is an increasing number of environment-caused diseases. Therefore, a medicine not coping with the environment is not credible. In today&apos;s medicine, for example, there are too many persistent detergents, water-polluting disinfectants, and many disposable materials. Too much water ist consumed, whereas the use of renewable energies is only limited. And too little natural healing methods are applied in diagnostics and therapy. Presently, in Germany, 16,7 million in-patients are treated in Germany, 1,16 million out-patients have surgeries in 2166 hospitals by ca. 1,1 million medical staff. All this work needs energy and materials which bring various risks to environment and the patients. During the last two decades, however, many efforts were made in the field of environment protection in medicine. There is hardly a hospital left which has not taken measures of protecting the environment. In the branch-specific quality management system KTQ (=cooperation for transparency and quality in the health system). environment protection measures are interrogated and systematically assessed.

Inhibition of. beta. -bungarotoxin binding to brain membranes by mast cell degranulating peptide, toxin I, and ethylene glycol bis(. beta. -aminoethyl ether)-N,N,N&apos;,N&apos;-tetraacetic acid

Energy Technology Data Exchange (ETDEWEB)

Schmidt, R.R.; Betz, H.; Rehm, H.

1988-02-09

The presynaptically active snake venom neurotoxin ..beta..-bungarotoxin (..beta..-Butx) is known to affect neurotransmitter release by binding to a subtype of voltage-activated K/sup +/ channels. Here the authors show that mast cell degranulating (MCD) peptide from bee venom inhibits the binding of /sup 125/I-labeled ..beta..-Butx to chick and rat brain membranes with apparent K/sub i/ values of 180 nM and 1100 nM, respectively. The mechanisms of inhibition of MCD peptide is noncompetitive, as is inhibition of /sup 125/I-..beta..-Butx binding by the protease inhibitor homologue from mamba venom, toxin I. ..beta..-Butx and its binding antagonists thus bind to different sites of the same membrane protein. Removal of Ca/sup 2 +/ by ethylene glycol bis(..beta..-aminoethyl ether)-N,N,N&apos;,N&apos;-tetraacetic acid inhibits the binding of /sup 125/I-..beta..-Butx by lowering its affinity to brain membranes.

&apos;&apos;de novo&apos;&apos; aneurysms following endovascular procedures

Energy Technology Data Exchange (ETDEWEB)

Briganti, F.; Cirillo, S.; Caranci, F. [Department of Neurological Sciences, Services of Neuroradiology, ' ' Federico II' ' University, Naples (Italy); Esposito, F.; Maiuri, F. [Department of Neurological Sciences, Services of Neurosurgery, ' ' Federico II' ' University, Naples (Italy)

2002-07-01

Two personal cases of &apos;&apos;de novo&apos;&apos; aneurysms of the anterior communicating artery (ACoA) occurring 9 and 4 years, respectively, after endovascular carotid occlusion are described. A review of the 30 reported cases (including our own two) of &apos;&apos;de novo&apos;&apos; aneurysms after occlusion of the major cerebral vessels has shown some features, including a rather long time interval after the endovascular procedure of up to 20-25 years (average 9.6 years), a preferential ACoA (36.3%) and internal carotid artery-posterior communicating artery (ICA-PCoA) (33.3%) location of the &apos;&apos;de novo&apos;&apos; aneurysms, and a 10% rate of multiple aneurysms. These data are compared with those of the group of reported spontaneous &apos;&apos;de novo&apos;&apos; aneurysms after SAH or previous aneurysm clipping. We agree that the frequency of &apos;&apos;de novo&apos;&apos; aneurysms after major-vessel occlusion (two among ten procedures in our series, or 20%) is higher than commonly reported (0 to 11%). For this reason, we suggest that patients who have been submitted to endovascular major-vessel occlusion be followed up for up to 20-25 years after the procedure, using non-invasive imaging studies such as MR angiography and high-resolution CT angiography. On the other hand, periodic digital angiography has a questionable risk-benefit ratio; it may be used when a &apos;&apos;de novo&apos;&apos; aneurysm is detected or suspected on non-invasive studies. The progressive enlargement of the ACoA after carotid occlusion, as described in our case 1, must be considered a radiological finding of risk for &apos;&apos;de novo&apos;&apos; aneurysm formation. (orig.)

MILLIMETRIC AND SUBMILLIMETRIC OBSERVATIONS OF IRAS 05327+3404 &apos;'HOLOEA'&apos; IN M36

Energy Technology Data Exchange (ETDEWEB)

Morata, O.; Ho, P. T. P. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 106, Taiwan (China); Kuan, Y.-J.; Huang, H.-C.; Zhao-Geisler, R. [Department of Earth Sciences, National Taiwan Normal University, 88 Section 4, Ting Chou Road, Taipei 116, Taiwan (China); Magnier, E. A., E-mail: omorata@asiaa.sinica.edu.tw [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

2013-09-15

The transition between the protostar, Class I, and the pre-main-sequence star, Class II, phases is still one of the most uncertain, and important, stages in the knowledge of the process of formation of an individual star because it is the stage that determines the final mass of the star. We observed the young stellar object &apos;'Holoea'&apos;, associated with IRAS 05327+3404, which was classified as an object in the transition between the Class I and Class II phases with several unusual properties, and appears to be surrounded by large amounts of circumstellar material. We used the SMA and BIMA telescopes at millimeter and submillimeter (submm) wavelengths to observe the dust continuum emission and the CO (1-0) and (2-1), HCO{sup +} (1-0) and (3-2), and HCN (1-0) transitions in the region around IRAS 05327+3404. We detected two continuum emission peaks at 1.1 mm: SMM 1, the submm counterpart of IRAS 05327+3404, and SMM 2, {approx}6 arcsec to the west. The emissions of the three molecules show marked differences. The CO emission near the systemic velocity is filtered out by the telescopes, and CO mostly traces the high-velocity gas. The HCO{sup +} and HCN emissions are more concentrated around the central parts of the region, and show several intensity peaks coincident with the submm continuum peaks. We identify two main molecular outflows: a bipolar outflow in an E-W direction that would be powered by SMM 1 and the other in a NE direction, which we associate with SMM 2. We propose that the SMM sources are probably Class I objects, with SMM 1 in an earlier evolutionary stage.

&apos;Atomic Bremsstrahlung&apos;: Retrospectives, current status and perspectives

Energy Technology Data Exchange (ETDEWEB)

Amusia, M.Ya. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel) and Ioffe Physical-Technical Institute, St. Petersburg 194021 (Russian Federation)]. E-mail: Amusia@vms.huji.ac.il

2006-10-15

We describe here the &apos;Atomic bremsstrahlung&apos; (AB)-emission of continuous spectrum electromagnetic radiation, which is generated in collisions of particles that have internal deformable structure that includes positively and negatively charged constituents. The deformation of one or both colliding partners induces multiple, mainly dipole, time-dependent electrical moments that become a source of radiation. The history of AB invention is presented and its unusual in comparison to ordinary bremsstrahlung (OB) properties, are discussed. As examples, fast electron atom, non-relativistic and relativistic collisions are considered. Attention is given to ion-atom and atom-atom collisions. Specifics of &apos;elastic&apos; and &apos;inelastic&apos; (i.e. radiation accompanied by destruction of collision partners) AB will be mentioned. Attention will be given to possible manifestation of AB in nature and in some exotic systems, for instance scattering of electrons upon muonic hydrogen. Some cooperative effects connected to AB will be considered. New classical schemes similar to AB will be presented.

Aspects of the cosmological &apos;&apos;coincidence problem&apos;&apos;

Energy Technology Data Exchange (ETDEWEB)

Velten, H.E.S.; Marttens, R.F. vom; Zimdahl, W. [Universidade Federal do Espirito Santo (UFES), Departamento de Fisica, Vitoria, Espirito Santo (Brazil)

2014-11-15

The observational fact that the present values of the densities of dark energy and dark matter are of the same order of magnitude, ρ{sub de0}/ρ{sub dm0} ∝ O(1), seems to indicate that we are currently living in a very special period of the cosmic history. Within the standard model, a density ratio of the order of one just at the present epoch can be seen as coincidental since it requires very special initial conditions in the early Universe. The corresponding &apos;&apos;why now&apos;&apos; question constitutes the cosmological &apos;&apos;coincidence problem&apos;&apos;. According to the standard model the equality ρ{sub de} = ρ{sub dm} took place &apos;'recently'&apos; at a redshift z ∼ 0.55. The meaning of &apos;'recently'&apos; is, however, parameter dependent. In terms of the cosmic time the situation looks different. We discuss several aspects of the &apos;&apos;coincidence problem&apos;&apos;, also in its relation to the cosmological constant problem, to issues of structure formation and to cosmic age considerations. (orig.)

REIMEP-22 inter-laboratory comparison. &apos;&apos;U Age Dating - determination of the production date of a uranium certified test sample&apos;&apos;

Energy Technology Data Exchange (ETDEWEB)

Venchiarutti, Celia; Richter, Stephan; Jakopic, Rozle; Aregbe, Yetunde [European Commission, Joint Research Centre (JRC), Geel (Belgium). Institute for Reference Materials and Measurements (IRMM); Varga, Zsolt; Mayer, Klaus [European Commission, Joint Research Centre (JRC), Karlsruhe (Germany). Institute for Transuranium Elements (ITU)

2015-07-01

The REIMEP-22 inter-laboratory comparison aimed at determining the production date of a uranium certified test sample (i.e. the last chemical separation date of the material). Participants in REIMEP-22 on &apos;&apos;U Age Dating - Determination of the production date of a uranium certified test sample&apos;&apos; received one low-enriched 20 mg uranium sample for mass spectrometry measurements and/or one 50 mg uranium sample for a-spectrometry measurements, with an undisclosed value for the production date. They were asked to report the isotope amount ratios n({sup 230}Th)/n({sup 234}U) for the 20 mg uranium sample and/or the activity ratios A({sup 230}Th)/A({sup 234}U) for the 50 mg uranium sample in addition to the calculated production date of the certified test samples with its uncertainty. Reporting of the {sup 231}Pa/{sup 235}U ratio and the respective calculated production date was optional. Eleven laboratories reported results in REIMEP-22. Two of them reported results for both the 20 mg and 50 mg uranium certified test samples. The measurement capability of the participants was assessed against the independent REIMEP-22 reference value by means of z- and zeta-scores in compliance with ISO 13528:2005. Furthermore a performance assessment criterion for acceptable uncertainty was applied to evaluate the participants&apos; results. In general, the REIMEP-22 participants&apos; results were satisfactory. This confirms the analytical capabilities of laboratories to determine accurately the age of uranium materials with low amount of ingrown thorium (young certified test sample). The Joint Research Centre of the European Commission (EC-JRC) organised REIMEP-22 in parallel to the preparation and certification of a uranium reference material certified for the production date (IRMM-1000a and IRMM-1000b).

Apolipoprotein A-I metabolism in cynomolgus monkey. Identification and characterization of beta-migrating pools

International Nuclear Information System (INIS)

Melchior, G.W.; Castle, C.K.

1989-01-01

Fresh plasma from control (C) and hypercholesterolemic (HC) cynomolgus monkeys was analyzed by agarose electrophoresis-immunoblotting with antibody to cynomolgus monkey apolipoprotein (apo) A-I. Two bands were evident on the autoradiogram: an alpha-migrating band (high density lipoprotein) and a beta-migrating band that comigrated exactly with cynomolgus monkey low density lipoprotein (LDL). The presence of beta-migrating apo A-I in the plasma of these monkeys was confirmed by Geon-Pevikon preparative electrophoresis, crossed immunoelectrophoresis, and isotope dilution studies in which radiolabeled apo A-I was found to equilibrate also with alpha- and beta-migrating pools of apo A-I in the plasma. Subfractionation of C and HC plasma by agarose column chromatography (Bio-Gel A-0.5M and A-15M) followed by agarose electrophoresis-immunoblotting indicated that the beta-migrating apo A-I in C was relatively homogeneous and eluted with proteins of Mr approximately 50 kD [apo A-I(50 kD)], whereas two beta-migrating fractions were identified in HC, one that eluted with the 50-kD proteins, and the other that eluted in the LDL Mr range [apo A-I(LDL)]. The apo A-I(LDL) was precipitated by antibody to cynomolgus monkey apo B. The apo A-I(50 kD) accounted for 5 +/- 1% (mean +/- SD) of the plasma apo A-I in C plasma, and 15 +/- 7% in HC plasma. No apo A-I(LDL) was detected in C plasma, but that fraction accounted for 9 +/- 7% of the apo A-I in HC plasma. These data establish the presence of multiple pools of apo A-I in the cynomolgus monkey, which must be taken into consideration in any comprehensive model of apo A-I metabolism in this species

Reflection group on &apos;Expert Culture&apos;

Energy Technology Data Exchange (ETDEWEB)

Eggermont, G

2000-07-01

As part of SCK-CEN&apos;s social sciences and humanities programme, a reflection group on &apos;Expert Culture&apos; was established. The objectives of the reflection group are: (1) to clarify the role of SCK-CEN experts; (2) to clarify the new role of expertise in the evolving context of risk society; (3) to confront external views and internal SCK-CEN experiences on expert culture; (4) to improve trust building of experts and credibility of SCK-CEN as a nuclear actor in society; (5) to develop a draft for a deontological code; (6) to integrate the approach in training on assertivity and communication; (7) to create an output for a topical day on the subject of expert culture. The programme, achievements and perspectives of the refection group are summarised.

Radioimmunoassay of human. beta. -lipotropin in unextracted plasma. [/sup 125/I tracer technique

Energy Technology Data Exchange (ETDEWEB)

Wiedemann, E. (Univ. of California, Berkeley); Saito, T.; Linfoot, J.A.; Li, C.H.

1977-11-01

A sensitive and specific radioimmunoassay for human ..beta..-lipotropin (..beta../sub h/-LPH) in unextracted plasma was developed using pure ..beta../sub h/-LPH as tracer and standard and an antiserum not cross-reacting with human ..beta..-MSH and hACTH. In healthy volunteers plasma ..beta../sub h/-LPH ranged from <20 to 150 pg/ml at 8:00 a.m. and rose after metyrapone administration. ..beta../sub h/-LPH was very low in panhypopituitarism, normal in most patients with untreated Cushing&apos;s disease, elevated in acromegaly and extremely high in Nelson&apos;s syndrome.

&apos;Am I as smart as my smart meter is?&apos; - Swedish experience of statistics feedback to households

Energy Technology Data Exchange (ETDEWEB)

Pyrko, Jurek (Lund University, Dept. of Energy Sciences (Sweden))

2011-07-01

This paper presents a synthesis of three cases from a study &apos;Information through digital channels and its potential to change electricity consumption patterns&apos; within Elforsk ELAN-programme, AMR-Visualisation carried out by scientists from the Efficient Energy Use in Buildings Research Group at the Department of Energy Sciences, Lund University - LTH, Sweden. The main objective was to investigate the influence of improved energy feedback (Internet-based energy statistics services) on electricity savings and the potential of changing electricity use patterns in Swedish dwellings. The three case studies were conducted in collaboration with respective grid companies. The analysis integrated both quantitative and qualitative methods in order to investigate different aspects of customers&apos; electricity consumption, energy behaviour, values and attitudes. Periods &apos;before&apos; and &apos;after&apos; the introduction of feedback measure were used. The customers were not influenced by the observations. An energy profile that would explore differences between users and non-users of the services (in terms of energy-related habits and behaviour) was used. The main hypothesis of this study assumed that the statistics service, as feedback to households, might lead to lower electricity consumption, thanks to better understanding of energy use patterns and costs. This hypothesis was not confirmed. The results of this study can be summarized in the following conclusions: - The users of the statistics service have shown either reduced or increased electricity use in the households. - The explanation why the households using the statistics service often have had increasing electricity usage could be that their rising power consumption caused a need to have better control over electricity needs and energy bills, and households started to use the statistics services for this reason. - The results did not confirm that users of statistics services have had significantly

Simultaneous Quantification of Apolipoprotein A-I and Apolipoprotein B by Liquid-Chromatography–Multiple-Reaction–Monitoring Mass Spectrometry

Science.gov (United States)

Agger, Sean A.; Marney, Luke C.; Hoofnagle, Andrew N.

2011-01-01

BACKGROUND If liquid-chromatography–multiple-reaction–monitoring mass spectrometry (LC-MRM/MS) could be used in the large-scale preclinical verification of putative biomarkers, it would obviate the need for the development of expensive immunoassays. In addition, the translation of novel biomarkers to clinical use would be accelerated if the assays used in preclinical studies were the same as those used in the clinical laboratory. To validate this approach, we developed a multiplexed assay for the quantification of 2 clinically well-known biomarkers in human plasma, apolipoprotein A-I and apolipoprotein B (apoA-I and apoB). METHODS We used PeptideAtlas to identify candidate peptides. Human samples were denatured with urea or trifluoroethanol, reduced and alkylated, and digested with trypsin. We compared reversed-phase chromatographic separation of peptides with normal flow and microflow, and we normalized endogenous peptide peak areas to internal standard peptides. We evaluated different methods of calibration and compared the final method with a nephelometric immunoassay. RESULTS We developed a final method using trifluoroethanol denaturation, 21-h digestion, normal flow chromatography-electrospray ionization, and calibration with a single normal human plasma sample. For samples injected in duplicate, the method had intraassay CVs <6% and interassay CVs <12% for both proteins, and compared well with immunoassay (n = 47; Deming regression, LC-MRM/MS = 1.17 × immunoassay – 36.6; Sx|y = 10.3 for apoA-I and LC-MRM/MS = 1.21 × immunoassay + 7.0; Sx|y = 7.9 for apoB). CONCLUSIONS Multiplexed quantification of proteins in human plasma/serum by LC-MRM/MS is possible and compares well with clinically useful immunoassays. The potential application of single-point calibration to large clinical studies could simplify efforts to reduce day-to-day digestion variability. PMID:20923952

BVR{sub c}I{sub c} OBSERVATIONS AND ANALYSES OF THE DWARF DETACHED BINARY V1043 CASSIOPEIA AND A COMMENT ON PRECONTACT W UMa&apos;S

Energy Technology Data Exchange (ETDEWEB)

Samec, R. G.; Smith, P. M.; Chamberlain, H. [Astronomy Group, Physics and Engineering Department, Bob Jones University, 1700 Wade Hampton Boulevard, Greenville, SC 29614 (United States); Faulkner, D. R. [Division of Math, Science, Nursing and Public Health, University of South Carolina, Lancaster, 476 Hubbard Drive, Lancaster, SC 29720 (United States); Van Hamme, W. [Physics Department, Florida International University, 11200 SW 8th Street, Miami, FL 33199 (United States)

2013-01-01

Complete Bessel BVR{sub c}I{sub c} light curves of V1043 Cassiopeia [2MASS J00371195+5301324, Mis V1292, USNO-A2.0 1425-00875743, {alpha}(2000) = 00{sup h}37{sup m}11.{sup s}95, {delta}(2000) = +53 Degree-Sign 01&apos;32.&apos;&apos;5] are analyzed. The system is a member of the small group of pre-contact W UMa binaries (PCWBs). Its light curve has the appearance of an Algol (EA) light curve, however it is made up of dwarf solar type components in a detached mode with a period of only 0.6616 days. The analysis includes a period study, an improved ephemeris, a mass ratio search, and a simultaneous BVR{sub c}I{sub c} Wilson-Devinney solution. We document about 20 other PCWBs given in the literature. Several have RS CVn-like properties.

KONTEC 2013. 11{sup th} international symposium on &apos;Conditioning of radioactive operational and decommissioning waste&apos; and 11{sup th} BMBF status report on &apos;Decommissioning and demolition of nuclear facilities&apos;; KONTEC 2013. 11. internationales Symposium &apos;Konditionierung radioaktiver Betriebs- und Stilllegungsabfaelle&apos; einschliesslich 11. Statusbericht des BMBF &apos;Stilllegung und Rueckbau kerntechnischer Anlagen&apos;. Veranstaltungsbericht

Energy Technology Data Exchange (ETDEWEB)

Anon.

2013-06-15

KONTEC 2013 was held in Dresden on 13 to 15 March 2013. The 11{sup th} event organized under this heading dealt with the subjects of &apos;Conditioning of Radioactive Operational and Decommissioning Waste&apos; and &apos;Decommissioning and Demolition of Nuclear Facilities&apos; including the R and D Status Report by the Federal Ministry of Education and Research (BMBF) on the same subject. The conference was attended by an international audience from 19 countries. The program included plenary sessions on these 4 key topics: - Disposal of Radioactive Residues from Nuclear Facilities&apos; Operation and Decommissioning. - Decommissioning and Dismantling of Nuclear Facilities. - Facilities and Systems for the Conditioning of Operational and Decommissioning Wastes. - Transport, Interim and Final Storage of Non-heat Generating Wastes (i.e. Konrad). These sessions were accompanied by poster sessions and short presentations under the heading of &apos;Kontec Direct.&apos; The best presentations of the categories Plenary Session Presentation, Poster Presentation and Kontec-Direct have been awarded. In detail, &apos;Dismantling of Russian nuclear powered submarines&apos; by Detlef Mietann, &apos;Requalification of &apos;Old Packages&apos; for the Konrad Repository Described for the Model Case of Packages from Storage Annex A and Repackaging of Containers Holding Compacts in Hall 2 of the GNS Plant&apos; by Martina Koessler, Sebastian Schwall and Pascal Budriks, and &apos;Electrochemical process development for cleaning organic, C-14-labelled waste solutions&apos; by Hans-Juergen Friedrich. (orig.)

Simple detection of hepatitis C virus using {sup 125}I-2&apos;-deoxyuridine triphosphate and gamma counter

Energy Technology Data Exchange (ETDEWEB)

Lee, Soo Jin; Ahn, S. H.; Chung, W. S.; Woo, K. S.; Lim, S. J.; Choi, C. W.; Lim, S. M. [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

2000-07-01

Hepatitis C Virus (HCV) is the major cause of post transfusion and sporadic non A, non B hepatitis. Current infection of HCV can be detected by PCR method. Using PCR, it has been possible to detect HCV viremia prior to immunological sero-conversion and to detect fluctuation of viremia in antibody-positive chronic HCV patients undergoing therapy with interferon. In this study, we established the simple method to detect HCV DNA by incorporation of {sup 125}I-deoxyuridine triphosphate(dUTP) into DNA during the PCR, and counted the radioactivity of PCR product by gamma counter. {sup 125}I-2&apos;-deoxyuridine 5&apos;-triphosphate was prepared, and incorporated into DNA during PCR. dUTP was radiolabeled by the iododemercuration of 5-mercuri intermediate. Iododemercuration labeling was completed with 98% yield and the obtained product was incorporated into DNA without further purification. After incorporation, covalently bonded radioiodine substituent was remained stable during PCR procedure HCV positive standard and positive patient sera in immunological assay were centrifuged. HCV RNA is isolated from by GTC(Guanidine Thiocyanate) and phenol/chloroform extraction method and synthesized complementary DNA by using reverse transcriptase. The &apos;1{sup 25}I-dUTP was incorporated into HCV C DNA during PCR. PCR product purified by fiber matrix column and counted by gamma counter. PCR products were electrophoresized, and autoradiography image obtained. Amplified HCV DNA by {sup 125}I-dUTP PCR obtained the band on the gel by electrophoresis and autoradiography at the same position. In patient sera, radioactivity of HCV positive sample was 8 times higher than HCV negative viremia sample. We established HCV detection method using {sup 125}I-dUTP. {sup 125}I-dUTP PCR detection of HCV is convenient and reporducible.

A telemanipulator&apos;s direct manipulation interface; Interfaccia a manipolazione diretta per un telemanipolatore

Energy Technology Data Exchange (ETDEWEB)

Zirilli, P.; Levialdi, S. [Rome Univ. La Sapienza, Rome (Italy). Dipt. Scienze dell' Informazione; Manzano, J.L. [ENEA, Centro Ricerche Casaccia, S. Maria di Galeria, RM (Italy). Dipt. Innovazione

1999-07-01

The report discusses the analysis results of the interface of the ENEA&apos;s (National Agency for New Technology, Energy and the Enumerative) telemanipulator Mascot. A criterion to measure the u suability of an interface and a paradigm to manipulate objects in a virtual environment using devices without force feedback are proposed. A prototype for the Mascot&apos;s interface and a simulator of the telemanipulator are described. [Italian] Vengono presentati i risultati dell&apos;analisi dell&apos;interfaccia Mascot, un telemanipolatore sviluppato dall&apos;ENEA. Si introduce un criterio di complessita&apos; per misurare l&apos;uso di un&apos;interfaccia e si propone un paradigma per l&apos;interazione con ambienti virtuali, applicabili alla manipolazione di oggetti tramite dispositivi che non forniscono controreazione di forza. Si descrive infine la realizzazione di un prototipo di un&apos;interfaccia e di un simulatore per l&apos;utilizzo del telemanipolatore.

Those who &apos;Cry Wolf&apos; about nuclear safety damage their own credibility

Energy Technology Data Exchange (ETDEWEB)

Shepherd, John [nuclear 24, Redditch (United Kingdom)

2016-06-15

Do you recall the fable of the boy who cried wolf? I was reminded of this following the latest call by Germany&apos;s Federal Environment Minister, Barbara Hendricks, for Belgium to take two of its nuclear reactors off the grid, citing &apos;'questions'&apos; about the units&apos; safety. Those in positions of power and influence in one country should take care to be as responsible in their dealings with their neighbours as they are in handling domestic matters of state. Those who see &apos;danger&apos; where there is none are not being good neighbours. They are generating fear and alarm without good cause and should mind their own business.

Synthesis and evaluation of [{sup 125}I]I-TSA as a brain nicotinic acetylcholine receptor {alpha}{sub 7} subtype imaging agent

Energy Technology Data Exchange (ETDEWEB)

Ogawa, Mikako [Laboratory of Genome Bio-Photonics, Photon Medical Research Center, Hamamatsu Medical University, Hamamatsu 431-3192 (Japan); Tatsumi, Ryo [Pharmaceuticals Research Unit, Research and Development Division, Mitsubishi Pharma Corporation, Yokohama 227-0033 (Japan); Fujio, Masakazu [Pharmaceuticals Research Unit, Research and Development Division, Mitsubishi Pharma Corporation, Yokohama 227-0033 (Japan); Katayama, Jiro [Pharmaceuticals Research Unit, Research and Development Division, Mitsubishi Pharma Corporation, Yokohama 227-0033 (Japan); Magata, Yasuhiro [Laboratory of Genome Bio-Photonics, Photon Medical Research Center, Hamamatsu Medical University, Hamamatsu 431-3192 (Japan)]. E-mail: magata@hama-med.ac.jp

2006-04-15

Introduction: Some in vitro investigations have suggested that the nicotinic acetylcholine receptor (nAChR) {alpha}{sub 7} subtype is implicated in Alzheimer&apos;s disease, schizophrenia and others. Recently, we developed (R)-3&apos;-(5-bromothiophen-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5&apos;-[1&apos;,3&apos;] oxazolidin]-2&apos;-one (Br-TSA), which has a high affinity and selectivity for {alpha}{sub 7} nAChRs. Therefore we synthesized (R)-3&apos;-(5-[{sup 125}I]iodothiophen-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5&apos;- [1&apos;,3&apos;]oxazolidin]-2&apos;-one ([{sup 125}I]I-TSA) and evaluated its potential for the in vivo detection of {alpha}{sub 7} nAChR in brain. Methods: In vitro binding affinity of I-TSA was measured in rat brain homogenates. Radioiodination was accomplished by a Br-I exchange reaction. Biodistribution studies were undertaken in mice by tail vein injection of [{sup 125}I]I-TSA. In vivo receptor blocking studies were carried out by treating mice with methyllycaconitine (MLA; 5 nmol/5 {mu}l, i.c.v.) or nonradioactive I-TSA (50 {mu}mol/kg, i.v.). Results: I-TSA exhibited a high affinity and selectivity for the {alpha}{sub 7} nAChR (K {sub i} for {alpha}{sub 7} nAChR=0.54 nM). Initial uptake in the brain was high (4.42 %dose/g at 5 min), and the clearance of radioactivity was relatively slow in the hippocampus ({alpha}{sub 7} nAChR-rich region) and was rather rapid in the cerebellum ({alpha}{sub 7} nAChR poor region). The hippocampus to cerebellum uptake ratio was 0.9 at 5 min postinjection, but it was increased to 1.8 at 60 min postinjection. Although the effect was not statistically significant, administration of I-TSA and MLA decreased the accumulation of radioactivity in hippocampus. Conclusion: Despite its high affinity and selectivity, [{sup 125}I]I-TSA does not appear to be a suitable tracer for in vivo {alpha}{sub 7} nAChR receptor imaging studies due to its high nonspecific binding. Further structural optimization is needed.

&apos;'Old'&apos; locked inflation

Energy Technology Data Exchange (ETDEWEB)

Liu, Yang; Piao, Yun-Song [College of Physical Sciences, Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Si, Zong-Guo, E-mail: liuyangbyf@mail.sdu.edu.cn, E-mail: yspiao@gucas.ac.cn, E-mail: zgsi@sdu.edu.cn [Department of Physics, Shandong University, Jinan 250100 (China)

2009-05-15

In this paper, we revisit the idea of locked inflation, which does not require a potential satisfying the normal slow-roll condition, but suffers from the problems associated with &apos;&apos;saddle inflation&apos;&apos;. We propose a scenario based on locked inflation, however, with an alternative evolution mechanism of the &apos;&apos;waterfall field&apos;&apos; {phi}. Instead of rolling down along the potential, the {phi} field will tunnel to end the inflation stage like in old inflation, by which the saddle inflation could be avoided. Further, we study a cascade of old locked inflation, which can be motivated by the string landscape. Our model is based on the consideration of making locked inflation feasible so as to give a working model without slow roll; It also can be seen as an effort to embed the old inflation in string landscape.

The influence of ApoE genotype on the lipid profile and lipoproteins ...

African Journals Online (AJOL)

The influence of ApoE genotype on the lipid profile and lipoproteins during normal pregnancy in a Southern African population. Donald Moshen Tanyanyiwa1,2, Adrian David Marais3, Pamela Byrnes3, Sheena Jones3. 1. Division of Human Genetics, Department of Pathology and Institute of Infectious Disease and ...

An exercise in &apos;anhomomorphic logic&apos;

Energy Technology Data Exchange (ETDEWEB)

Sorkin, Rafael D [Perimeter Institute, 31 Caroline Street North, Waterloo ON, N2L 2Y5 (Canada); Department of Physics, Syracuse University, Syracuse, NY 13244-1130 (United States)

2007-05-15

A classical logic exhibits a threefold inner structure comprising an algebra of propositions U, a space of &apos;truth values&apos; V, and a distinguished family of mappings {phi} from propositions to truth values. Classically U is a Boolean algebra, V = Z{sub 2}, and the admissible maps {phi}: U Z{sub 2} are homomorphisms. If one admits a larger set of maps, one obtains an anhomomorphic logic that seems better suited to quantal reality (and the needs of quantum gravity). I explain these ideas and illustrate them with three simple examples.

Development of a research prototype computer &apos;Wearables&apos; that one can wear on his or her body. Minitsukeru computer &apos;Wearables&apos; kenkyuyo shisakuki wo kaihatsu

Energy Technology Data Exchange (ETDEWEB)

1999-02-01

Development has been made on a prototype of a wearable computer &apos;Wearables&apos; that makes the present notebook type PC still smaller in size, can be worn on human body for utilization at any time and from anywhere, and aims at realizing a social infrastructure. Using the company&apos;s portable PC, Libretto as the base, the keyboard and the liquid crystal display panel were removed. To replace these functions, a voice inputting microphone, and various types of head mounting type displays (glasses type) mounted on a head to see images are connected. Provided as the means for information communication between the prototype computer and outside environments are infrared ray interface and data communication function using wireless (electric wave) communications. The wireless desk area network (DAN) technology that can structure dynamically a network between multiple number of computers has realized smooth communications with external environments. The voice recognition technology that can work efficiently against noise has realized keyboard-free operation that gives no neural stress to users. The &apos;wearable computer&apos; aims at not only users utilizing it simply wearing it, but also providing a new perception ability that could not have been seen or heard directly to date, that is realizing the digital sensation. With the computer, a society will be structured in which people can live comfortably and safely, maintaining conversations between the users and the computers, and interactions between the surrounding environment and the social infrastructures, with protection of individual privacy and information security taken into consideration. The company is working with the Massachusetts Institute of Technology (MIT) for research and development of the &apos;wearable computer&apos; as to how it can be utilized and basic technologies that will be required in the future. (translated by NEDO)

Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells.

Science.gov (United States)

Lin, Jianfei; Chen, He; Luo, Ling; Lai, Yongrong; Xie, Wei; Kee, Kehkooi

2015-01-01

To correct a DNA mutation in the human genome for gene therapy, homology-directed repair (HDR) needs to be specific and have the lowest off-target effects to protect the human genome from deleterious mutations. Zinc finger nucleases, transcription activator-like effector nuclease (TALEN) and CRISPR-CAS9 systems have been engineered and used extensively to recognize and modify specific DNA sequences. Although TALEN and CRISPR/CAS9 could induce high levels of HDR in human cells, their genotoxicity was significantly higher. Here, we report the creation of a monomeric endonuclease that can recognize at least 33 bp by fusing the DNA-recognizing domain of TALEN (TALE) to a re-engineered homing endonuclease I-SceI. After sequentially re-engineering I-SceI to recognize 18 bp of the human β-globin sequence, the re-engineered I-SceI induced HDR in human cells. When the re-engineered I-SceI was fused to TALE (TALE-ISVB2), the chimeric endonuclease induced the same HDR rate at the human β-globin gene locus as that induced by TALEN, but significantly reduced genotoxicity. We further demonstrated that TALE-ISVB2 specifically targeted at the β-globin sequence in human hematopoietic stem cells. Therefore, this monomeric endonuclease has the potential to be used in therapeutic gene targeting in human cells. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Solar campaign &apos;Solar - na klar.&apos; (solar - of course). Final report; Solarkampagne &apos;Solar - na klar.&apos;. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Gege, M.; Kleinsteuber, A.; Krabbe, P.; Kroeger, P.; Maschke, K.; Niedert, S.; Schindelmann, F.; Thunert, A.; Weinberg, H.

2002-03-18

The German market for technically matured solar-thermal systems for generating hot water is growing by 20 per cent per year, with some deviations due to incentive policies. This growth can be and is planned to be increased systematically, with following goals: A practical contribution to the Federal Government&apos;s efforts to achieve the goals regarding the protection of climate; creating future-oriented jobs; supporting ecologically sustainable ways of life and models of consumption by convincing the consumers and other target groups of the fact that it makes sense already today to start utilizing solar energy and to invest also on private basis. These targets are expected to be set up with the help of a three-year mass campaign (1999 until 2001), i.e. the campaign called &apos;&apos;Solar - na klar.&apos;&apos; (solar - of course). [German] Der deutsche Markt fuer die technisch ausgereiften solarthermischen Anlagen zur Warmwassererzeugung waechst mit ca. 20% p.a., mit foerderpolitisch bedingten Schwankungen. Dieses Wachstum kann und soll systematisch gesteigert werden, mit folgenden Zielsetzungen: Praktischer Beitrag zur Erreichung der Klimaschutzziele der Bundesregierung; Schaffung zukunftsorientierter Arbeitsplaetze; Befoerderung oekologisch nachhaltiger Lebensstile und Konsummuster durch die Ueberzeugung der Verbraucher und weiterer Zielgruppen, dass es heute bereits sinnvoll ist, in die Nutzung der Solarenergie konkret einzusteigen und auch privat zu investieren. Diese Ziele sollen mithilfe einer auf drei Jahre angelegten Breitenkampagne (1999 bis 2001), d.h. der Kampagne &apos;Solar - na klar.&apos; erfolgen. (orig.)

Proceedings of the 5. International Topical Meeting on Nuclear Plant Instrumentation Controls, and Human Machine Interface Technology

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

Instrumentation, Controls, and Human-Machine Interface (ICHMI) technologies are essential to ensuring delivery and effective operation of nuclear power systems. The ICHMI system, together with plant personnel, is the &apos;central nervous system&apos; for operating plants. It senses basic parameters, monitors performance, integrates information, and makes adjustments to plant operations as necessary. It also responds to failures and off-normal events, thus ensuring goals of efficient power production and safety. The ICHMI system embodies the sensing, communications, monitoring, control, and presentation and command systems between the process (i.e., the reactor, heat transport, and energy conversion systems) and the plant personnel. It enables plant personnel to more effectively monitor the health of the plant and to identify opportunities to improve the performance of equipment and systems as well as to anticipate, understand, and respond to potential problems. Improved controls provide the basis to operate more closely to performance margins, and the improved integration of automatic and human response enables them to work cooperatively to accomplish production and safety goals. The ICHMI system thus directly impacts the performance of the entire plant and thereby the economics, safety, and security of current and future reactor designs. The 5. International Topical Meeting on Nuclear Plant Instrumentation Control and Human-Machine Interface Technology (NPIC and HMIT 2006) is specifically devoted to advances in these important technologies. In these proceedings, more than 200 papers and panel sessions from all over the world have been assembled to share the most recent information and innovations in ICHMI technology and to discuss the important issues that face the future of the industry. The papers fall into two major groupings: instrumentation and control (I and C) and human-machine interface technology (HMIT). The I and C papers are organized into five tracks

&apos;&apos;Is it really green?&apos;&apos; Long-term performance of monocrystalline solar modules as illustrated by the example of a photovoltaic pumping station in a natural reserve (&apos;&apos;Schwenninger Moos&apos;&apos;); &apos;&apos;Is it really green?&apos;&apos; Langzeiterfahrung mit monokristallinen Solarmodulen am Beispiel der photovoltaischen Pumpstation Schwenninger Moos

Energy Technology Data Exchange (ETDEWEB)

Assbeck, Franz [Hochschule Furtwangen (Germany). Fakultaet Computer und Electrical Engineering

2010-03-15

In 1991, a photovoltaic pumping station was commissioned in the natural reserve &apos;&apos;Schwenninger Moos&apos;&apos; in the southern Black Forest. The pumping station was dismantled when the land was used for the 2010 Baden-Wuerttemberg &apos;Landesgartenschau&apos; (garden festival). After 18 years of operation, the plant provided valuable information on the long-term performance of monocrystalline solar modules, so the author made detailed measurements and evaluations just before the plant was dismantled, in an attempt to find out about its long-term performance and cost efficiency. The results are presented here. (orig.)

Progressive Presentations of Place-Based Identities in Meg Rosoff&apos;s "How I Live Now"

Science.gov (United States)

Lockney, Karen

2013-01-01

This article provides a close reading of Meg Rosoff&apos;s award-winning novel "How I Live Now". It argues that an understanding of the text can be extended through an application of ideas found in contemporary spatial discourse concerning place. Reading the novel within this context allows a discussion of ways in which it draws on…

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein

Directory of Open Access Journals (Sweden)

Ioannis Papaioannou

2012-01-01

Full Text Available Cardiovascular disease is the leading worldwide cause of death. Apolipoprotein E (ApoE is a 34-kDa circulating glycoprotein, secreted by the liver and macrophages with pleiotropic antiatherogenic functions and hence a candidate to treat hypercholesterolaemia and atherosclerosis. Here, we describe atheroprotective properties of ApoE, though also potential proatherogenic actions, and the prevalence of dysfunctional isoforms, outline conventional gene transfer strategies, and then focus on gene correction therapeutics that can repair defective APOE alleles. In particular, we discuss the possibility and potential benefit of applying in combination two technical advances to repair aberrant APOE genes: (i an engineered endonuclease to introduce a double-strand break (DSB in exon 4, which contains the common, but dysfunctional, ε2 and ε4 alleles; (ii an efficient and selectable template for homologous recombination (HR repair, namely, an adeno-associated viral (AAV vector, which harbours wild-type APOE sequence. This technology is applicable ex vivo, for example to target haematopoietic or induced pluripotent stem cells, and also for in vivo hepatic gene targeting. It is to be hoped that such emerging technology will eventually translate to patient therapy to reduce CVD risk.

Characterization and behavior in the environment of the crude oil &apos;'Prestige'&apos;; Caracterisation et comportement dans l&apos;environnement du fioul &apos;'Prestige'&apos;

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-03-01

This study presents analysis realized on the crude oil of the tanker &apos;'Prestige'&apos; which sunk the 19 november 2002. The specifications on the product and its behavior in sea water are detailed. All the analysis are compared to the &apos;'Erika'&apos; crude oil. (A.L.B.)

In vitro metabolism of 2,2&apos;,3,4&apos;,5,5&apos;,6-heptachlorobiphenyl(CB187) with liver microsomes of rats, hamsters and guinea pigs

Energy Technology Data Exchange (ETDEWEB)

Koga, N.; Ohta, C.; Kanamaru, T. [Nakamura Gakuen Univ., Fukuoka (Japan); Haraguchi, K. [Daiichi Coll. of Pharmaceutical Sciences, Fukuoka (Japan); Kato, Y.; Yamada, S. [Univ. of Shizuoka, Shizuoka (Japan)

2004-09-15

PCB congeners possess extremely high lipophilicity and biological stability, and as a result they are not easily eliminated from the body once ingested. In particular, not only 2,4,5-trichlorosubstituted but also 6 or more chlorine-substituted PCBs such as 2,2&apos;,3&apos;,4,4&apos;,5-hexa-chlorobiphenyl (hexaCB) (CB138), 2,2&apos;,4,4&apos;,5,5&apos;-hexaCB (CB153), 2,2&apos;,3,4,4&apos;,5,5&apos;-heptachloro-biphenyl (heptaCB) (CB180) and 2,2&apos;,3,4&apos;,5,5&apos;,6-heptaCB (CB187) have been detected in blood and adipose tissues of mammals and human mother&apos;s milk at higher concentration. In addition, the 4-hydroxy (OH)-metabolite of CB187 has been reported to be present in human blood at the highest concentration of that derived from other PCB congeners. Although CB187, a tri-ortho-PCB, is one of the minor component in the commercial PCB preparations such as Clophen, Aroclor and Kanechlor, the toxic equivalency factor (TEF) which is used for dioxin-like PCB congeners including coplanar-PCBs and mono-ortho-PCBs to assess the potency of the toxicity has not been set up for di- and tri-ortho-PCB congeners. These facts indicate that 4-OH-PCB187 become more persistent and more important toxicologically than the parent CB187. However, there is little report about biotransformation in vivo or in vitro of CB187 in animals. Therefore, we examined CB187 metabolism by liver microsomes of rats, hamsters and guinea pigs.

Energy and the new class. [Assault of &apos;&apos;new breed&apos;&apos; of American on established institutions

Energy Technology Data Exchange (ETDEWEB)

King, L.

1979-03-14

The bounty of the US is taken for granted by its population. Nowhere is this misvaluation of a society and its benefits more evident than in the energy industries. But energy represents a tool by which society can be shaped; a device by which the standared of living and the very nature of the national lifestyle can be controlled, modified, amplified, or reduced. Two examples examined to show how energy shapes social order and human life are the women&apos;s movement and the desire to live in the Sunbelt. Five phenomena are then examined to point out the desire to restrain the nation&apos;s rampant pursuit of a higher standard of living, as opposed to the more subjective and seemingly more desirable goal of a better quality of life: the civil rights movement; the environmental movement; the Vietnam War; the Watergate scandal; and the assumption that prosperity at today&apos;s level is irreducible, concrete, and not subject to diminution. The &apos;&apos;new class&apos;&apos; is essentially made up of those educated in the liberal arts, divorced from an understanding of the mechanics of free-enterprise institutions and of the sicences. The antagonistic view of the new class of corporations and its assault on established institutions are noted. Energy companies are frustrated in telling their story, but the story that must be told is not the story of how excellently the energy sector has performed, but the story of how a new breed of Americans is seeking to remake America in its own image without the rest being aware of what is going on. (MCW)

BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet

OpenAIRE

Williams, Jarrod; Ensor, Charles; Gardner, Scott; Smith, Rebecca; Lodder, Robert

2015-01-01

Objective This study tests the hypothesis that BSN723T can prevent the development of hyperlipidemia and atherosclerosis in ApoE-/- knockout mice fed a Western (high fat, high cholesterol, and high sucrose) diet. BSN723T is a combination drug therapy consisting of D-tagatose and dihydromyricetin (BSN723). Background D-tagatose has an antihyperglycemic effect in animal and human studies and shows promise as a treatment for type 2 diabetes and obesity. Many claims regarding BSN723's pharmacolog...

Energy efficiency ground-source energy system, Environmental Protection Law, article &apos;Heat and cold storage, value for money&apos;; Energierendement bodemenergiesysteem, Wet milieubeheer, artikel &apos;WKO, waar voor je geld&apos;

Energy Technology Data Exchange (ETDEWEB)

Lambregts, E.G.M.; Teunissen, P.O.M.; Beukenhorst, E.

2013-01-15

Upscaling of ground-source energy systems can contribute to heat and cold storage systems and thus reduce CO2 emission for the Amsterdam municipality. Based on the results of the project &apos;Heat and cold storage; Value for money&apos; a proposal was made to the Dutch Ministry of Infrastructure and Environment to include a regulation &apos;energy efficiency heat and cold storage&apos; in the Environmental Protection Law [Dutch] In het kader van de CO2 doelstelling van Amsterdam om 40% CO2 te reduceren in 2025 t.o.v. van 1990 wordt de verdere opschaling van de techniek bodemenergiesysteem gezien als een techniek die in belangrijke mate kan bijdragen aan de pijler &apos;transitie duurzame warmte en koude&apos;. Op landelijk en gemeentelijk niveau werd gesignaleerd dat (open) bodemenergiesystemen in de exploitatiefase veelal onvoldoende functioneerden. In dit rapport wordt op basis van de resultaten van het project &apos;WKO, waar voor je geld&apos; een voorstel aan het Ministerie van I en M gedaan om een voorschrift &apos;energierendement wko&apos; op te nemen in het Activiteitenbesluit Wet milieubeheer.

A new method for studying iodine metabolism; the isotopic equilibrium method - kinetic and quantitative aspects of measurements made on rats; Une nouvelle methode d&apos;etude du metabolisme de l&apos;iode: la methode d&apos;equilibre isotopique - aspects cinetiques et quantitatifs obtenus chez le rat

Energy Technology Data Exchange (ETDEWEB)

Simon, C. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-05-15

The isotopic equilibrium method which has been developed in the case of the rat has made it possible to measure the absolute values of the principal parameters of iodine metabolism in this animal. The quantities and concentrations of iodine have been measured in the thyroid gland and in the plasma with a sensitivity of 0.001 {mu}g of {sup 127}I. This sensitivity has made it possible to measure pools as small as the iodide and the free iodotyrosines of the thyroid and to demonstrate the absence of free iodotyrosines in the plasma of the normal rat. In vivo, the isotopic equilibrium method has made it possible to measure the iodine content of the thyroid gland and to calculate the intensity of this gland&apos;s secretion without removing it. By double labelling with {sup 125}I and {sup 131}I the isotopic equilibrium method has made it possible to measure the flux, intensity of the intrathyroidal recycling as well as the turnover rates of all the iodine containing compounds of the thyroid gland. For this gland no precursor-product relationship has been found between The iodotyrosines (MIT and DIT) and the iodothyronines (T{sub 4} and T{sub 3}). The absence of this relationship is due to the heterogeneity of the thyroglobulin turnover. It has been shown furthermore that there exists in the plasma an organic fraction of the iodine which is different to thyroglobulin and which is renewed more rapidly than the circulating hormones T{sub 3} and T{sub 4}. The isotopic equilibrium method is very useful for series measurements of iodine. It makes it possible furthermore to improve the biochemical fractionations by adding carriers without affecting the subsequent {sup 127}I measurements. (author) [French] La methode d&apos;equilibre isotopique, mise au point chez le rat, a permis de mesurer en valeur absolue les principaux parametres du metabolisme de l&apos;iode chez cet animal. Les quantites ou les concentrations d&apos;iode ont ete mesurees pour la thyroide et pour le

"I&apos;m Really Glad This Is Developmental": Autism and Social Comparisons--An Interpretative Phenomenological Analysis

Science.gov (United States)

Huws, Jaci C.; Jones, Robert S. P.

2015-01-01

The present qualitative study comprised interviews with nine young people with autism (aged 16-21 years) about their perceptions of autism. Using interpretative phenomenological analysis, three underlying themes were illuminated, and all these formed the superordinate theme Making Comparisons: (a) Changes over time: "I&apos;m really glad this…

Cultured human astrocytes secrete large cholesteryl ester- andtriglyceride-rich lipoproteins along with endothelial lipase

Energy Technology Data Exchange (ETDEWEB)

Yang, Lin; Liu, Yanzhu; Forte, Trudy M.; Chisholm, Jeffrey W.; Parks, John S.; Shachter, Neil S.

2003-12-01

We cultured normal human astrocytes and characterized their secreted lipoproteins. Human astrocytes secreted lipoproteins in the size range of plasma VLDL (Peak 1), LDL (Peak 2), HDL (Peak 3) and a smaller peak (Peak 4), as determined by gel filtration chromatography, nondenaturing gradient gel electrophoresis and transmission electron microscopy. Cholesterol enrichment of astrocytes led to a particular increase in Peak 1. Almost all Peak 2, 3 and 4 cholesterol and most Peak 1 cholesterol was esterified (unlike mouse astrocyte lipoproteins, which exhibited similar peaks but where cholesterol was predominantly non-esterified). Triglycerides were present at about 2/3 the level of cholesterol. LCAT was detected along with two of its activators, apolipoprotein (apo) A-IV and apoC-I. ApoA-I and apoA-II mRNA and protein were absent. ApoJ was present equally in all peaks but apoE was present predominantly in peaks 3 and 4. ApoB was not detected. The electron microscopic appearance of Peak 1 lipoproteins suggested partial lipolysis leading to the detection of a heparin-releasable triglyceride lipase consistent with endothelial lipase. The increased neuronal delivery of lipids from large lipoprotein particles, for which apoE4 has greater affinity than does apoE3, may be a mechanism whereby the apoE {var_epsilon}4 allele contributes to neurodegenerative risk.

Electrosmotic conductivity in fine grained soils; Permeabilita&apos; elettroosmotica in terreni a grana fine

Energy Technology Data Exchange (ETDEWEB)

Fava, G.; Giaco' , A.; Pasqualini, E.; Sani, D. [Ancona Univ., Ancona (Italy). Dipt. di Scienze dei Materiali e della Terra

1999-10-01

In this work, aspects relating to the process of mass and energy flows in fine grained soil under an electrical field are considered. A suitable apparatus for the study of electrokinetic phenomena and the measure of electrosmotic conductivity coefficients is projected and constructed. The obtained results are reliable and in accord with the common literature data. The values of the electrosmotic conductivity obtained depend on the cation exchange capacity of utilised soils and on the effective porosity of investigated samples. [Italian] Nel presente lavoro sono presi in esame gli aspetti generali relativi ai processi che regolano i flussi di materia e di energia nei terreni a grana fine in presenza di un campo elettrico. Vengono presentati i risultati di una sperimentazione su di un dispositivo appositamente progettato e realizzato per la misura della permeabilita&apos; elettroosmotica e lo studio del trasporto elettrocinetico. I dati ottenuti sono risultati ripetibili e confrontabili con valori di letteratura consolidati. E&apos; stato riscontrato che i coefficienti di permeabilita&apos; elettroosmotica dipendono dalla capacita&apos; di scambio cationico del terreno selezionato e dalla porosita&apos; efficace dei campioni.

The &apos;mini&apos; and &apos;micro&apos; energy sources and their limitations; Les &apos;'minis'&apos; et &apos;'micros'&apos; sources d&apos;energie et leurs limites

Energy Technology Data Exchange (ETDEWEB)

Anon.

2004-03-01

The &apos;Science and defense 2003&apos; colloquium took place in Paris on December 2 and 3. It was organized by the general delegation of armament (DGA), the French atomic energy commission (CEA) with the participation of the national center of scientific research (CNRS) and the French ministry of research and new technologies. The main topic was the needs and the solutions implemented in the domain of energy sources both for civil and military portable applications. This article make a general summary of the content of this colloquium only in the domain of small power energy sources: emergence of new miniaturized portable devices (phones, computers, cameras, autonomous medical systems, wireless communication systems, soldiers equipments, drones etc..), improvement of batteries energy density and price, new needs linked with new functionalities, technological challenges (energy generation and recovery systems, miniaturized fuel-cells, use of recoverable energy sources, implantation of power sources in the human body etc..), new technological files (new electrode materials, micron- or sub-micron scale mechanical and electronic components, sensors, micro-motors, transfer of microelectronics technologies, hybrid systems..), international competition. (J.S.)

Changes in the &apos;medical research&apos; licensing procedure under the German Radiation Protection Ordinance; Neuerungen im Genehmigungsverfahren &apos;Medizinische Forschung&apos; gemaess Roentgen- und Strahlenschutzverordnung

Energy Technology Data Exchange (ETDEWEB)

Habeck, M.; Minkov, V.; Griebel, J.; Brix, G. [Bundesamt fuer Strahlenschutz (BfS), Oberschleissheim-Neuherberg (Germany). Fachbereich Strahlenschutz und Gesundheit; Epsch, R.; Langer, M. [Deutsche Roentgengesellschaft e.V. (DRG), Berlin (Germany). Klinische Studienkoordination

2012-06-15

This publication outlines the &apos;medical research&apos; licensing procedure as specified in the amendment of the German Radiation Protection Ordinance of November 1, 2011. The general licensing requirements for the use of radiation have not been changed by the amendment. Three so-called use restrictions (i.e., dose limits of 10 mSv and 20 mSv, age limit of 50 years) have been modified. They will only apply to healthy volunteers in the future. In addition, there are considerable simplifications with respect to applications and licensing procedures of the Federal Office for Radiation Protection (Bundesamt fuer Strahlenschutz, BfS) regarding the use of radiation in the newly introduced &apos;accompanying diagnostics&apos; (&apos;Begleitdiagnostik&apos;) case group. The newly established, independent panel of experts at the German Radiological Society (Deutsche Roentgengesellschaft, DRG) may provide essential support to principal investigators, qualified physicians and sponsors for differentiating between &apos;medical research&apos; and &apos;health care&apos;, the latter not being subject to licensing. An expert statement will be issued by the DRG within four weeks of an inquiry. This consulting service is subject to confidentiality, and is free of charge for inquirers and without any commitment. (orig.)

The &apos;&apos;rising bubble&apos;&apos; sign: a new aid in the diagnosis of unicameral bone cysts

Energy Technology Data Exchange (ETDEWEB)

Jordanov, Martin I. [Vanderbilt University Medical Center, Department of Radiology and Radiological Sciences, Nashville, TN (United States)

2009-06-15

The observation of a bubble of gas at the most non-dependent margin of a lytic bone lesion which has sustained a pathologic fracture implies that the lesion is hollow and can assist the radiologist in making the diagnosis of a unicameral bone cyst. The imaging studies of two patients who sustained pathologic fractures through unicameral bone cysts and exhibited the &apos;&apos;rising bubble&apos;&apos; sign are shown. The sign&apos;s basis, proper utilization, and potential pitfalls are discussed. (orig.)

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Science.gov (United States)

Achariyar, Thiyagaragan M; Li, Baoman; Peng, Weiguo; Verghese, Philip B; Shi, Yang; McConnell, Evan; Benraiss, Abdellatif; Kasper, Tristan; Song, Wei; Takano, Takahiro; Holtzman, David M; Nedergaard, Maiken; Deane, Rashid

2016-12-08

Apolipoprotein E (apoE) is a major carrier of cholesterol and essential for synaptic plasticity. In brain, it's expressed by many cells but highly expressed by the choroid plexus and the predominant apolipoprotein in cerebrospinal fluid (CSF). The role of apoE in the CSF is unclear. Recently, the glymphatic system was described as a clearance system whereby CSF and ISF (interstitial fluid) is exchanged via the peri-arterial space and convective flow of ISF clearance is mediated by aquaporin 4 (AQP4), a water channel. We reasoned that this system also serves to distribute essential molecules in CSF into brain. The aim was to establish whether apoE in CSF, secreted by the choroid plexus, is distributed into brain, and whether this distribution pattern was altered by sleep deprivation. We used fluorescently labeled lipidated apoE isoforms, lenti-apoE3 delivered to the choroid plexus, immunohistochemistry to map apoE brain distribution, immunolabeled cells and proteins in brain, Western blot analysis and ELISA to determine apoE levels and radiolabeled molecules to quantify CSF inflow into brain and brain clearance in mice. Data were statistically analyzed using ANOVA or Student's t- test. We show that the glymphatic fluid transporting system contributes to the delivery of choroid plexus/CSF-derived human apoE to neurons. CSF-delivered human apoE entered brain via the perivascular space of penetrating arteries and flows radially around arteries, but not veins, in an isoform specific manner (apoE2 > apoE3 > apoE4). Flow of apoE around arteries was facilitated by AQP4, a characteristic feature of the glymphatic system. ApoE3, delivered by lentivirus to the choroid plexus and ependymal layer but not to the parenchymal cells, was present in the CSF, penetrating arteries and neurons. The inflow of CSF, which contains apoE, into brain and its clearance from the interstitium were severely suppressed by sleep deprivation compared to the sleep state. Thus, choroid plexus

A comment on &apos;'A test of general relativity using the LARES and LAGEOS satellites and a GRACE Earth gravity model&apos;&apos;, by I. Ciufolini et al

Energy Technology Data Exchange (ETDEWEB)

Iorio, Lorenzo [Ministero dell' Istruzione Univ. della Ricerca (M.I.U.R.), Bari (Italy)

2017-02-15

Recently, Ciufolini et al. reported on a test of the general relativistic gravitomagnetic Lense-Thirring effect by analyzing about 3.5 years of laser ranging data to the LAGEOS, LAGEOS II, LARES geodetic satellites orbiting the Earth. By using the GRACE-based GGM05S Earth&apos;s global gravity model and a linear combination of the nodes Ω of the three satellites designed to remove the impact of errors in the first two even zonal harmonic coefficients J{sub 2}, J{sub 4} of the multipolar expansion of the Newtonian part of the Earth&apos;s gravitational potential, they claimed an overall accuracy of 5% for the Lense-Thirring caused node motion. We show that the scatter in the nominal values of the uncancelled even zonals of degree l = 6, 8, 10 from some of the most recent global gravity models does not yet allow to reach unambiguously and univocally the expected ∼1% level, being large up to

Nuclear waste disposal. A wicked and highly conflict bearing societal problem; Nukleare Entsorgung. Ein &apos;'wicked'&apos; und hoechst konfliktbehaftetes Gesellschaftsproblem

Energy Technology Data Exchange (ETDEWEB)

Brunnengraeber, Achim; Mez, Lutz [Freie Univ. Berlin (Germany). Forschungszentrum fuer Umweltpolitik; Di Nucci, Maria Rosaria; Schreuers, Miranda [Freie Univ. Berlin (Germany)

2012-12-15

The final disposal of nuclear wastes is called &apos;'messy'&apos; or &apos;'wicked'&apos; in the political science literature. The highly complicated problems are characterized by a number of features such as intra- and inter-generational aspects and ethical questions. In the case of stakeholders the differences concern ideologies, interests, merits and preferences that cause conflicts. The search for solutions is complicated due to interacting political, social, ecologic, economic and technical aspects. The concepts &apos;&apos;wicked problems&apos;&apos; and &apos;'multi-level-governance'&apos; are promising approaches to solve the complicated situation.

Experimental project with &apos;&apos;green fingers&apos;&apos;. A monitoring informs on successes and failures of Helsinki&apos;s Eco-City; Experimentelles Projekt mit &apos;&apos;gruenen Fingern&apos;&apos;. Ein Monitoring gibt Auskunft ueber Erfolge und Misserfolge von Helsinkis &apos;'Oeko-Stadt'&apos;

Energy Technology Data Exchange (ETDEWEB)

Meyer, Ulf [Kansas State Univ., Manhattan, KS (United States). Sustainable Architecture and Urban Design

2012-07-01

Of all things, at the extreme edge of Europe, the future of the European city is being rethought: with the new neighborhood &apos;'Viikki'&apos; the Finnish capital Helsinki has built their first eco-city. Eight years after its completion it is time for an evaluation. The founders draw a quite self-critical summary. The monitoring of Eco-Viikki is unusually accurate and thus gives interesting insights for other construction projects in Europe.

Werner Heisenberg. The language of the atoms. Life and work - a scientific biography - the &apos;&apos;joyous science&apos;&apos; (youth until Nobel price); Werner Heisenberg. Die Sprache der Atome. Leben und Wirken - Eine wissenschaftliche Biographie - Die &apos;&apos;froehliche Wissenschaft&apos;&apos; (Jugend bis Nobelpreis)

Energy Technology Data Exchange (ETDEWEB)

Rechenberg, Helmut [MPI fuer Physik, Muenchen (Germany). Werner-Heisenberg-Institut

2010-07-01

With his discovery that measuring values of complementary fundamental quantities in the microscopic world cannot by arbitrarily precisely determined cutted Werner Heisenberg the Gordian knot for the finishing of quantum theory developed by Planck, Einstein, and others and opened by this a new &apos;&apos;golden era&apos;&apos; in the physics of the 20th century. On the base of the documents from his life and work, i. e. deeds, letters and reports of contemporaries, as well as the published and unpublished essays, books, and articles of Heisenberg - also the later on found, publications or manuscripts mainly coming from the inheritance - resulted this systematic biography of Heisenberg. The author, the last doctoral candidate of Heisenberg relied furthermore on factual and personal knowledges, mainly own remembrances on his doctoral father and his teachers, colleagues, and students. Because of the interest of an authentical biography of the theoretical physicist Heisenberg the presentation of the mathematical approaches and the corresponding derivations could not completely be abandoned. This biography appeals by this both to a scientifically cultivated as a wider in science interested audience and covers the first phase of Heisenberg&apos;s life until his Nobel price 1933. [German] Mit seiner Entdeckung, dass sich Messwerte komplementaerer Groessen in der mikroskopischen Welt nicht beliebig genau bestimmen lassen, durchschnitt Werner Heisenberg den Gordischen Knoten zur Vollendung der von Planck, Einstein und anderen entwickelten Quantentheorie und eroeffnete damit ein neues &apos;&apos;goldenes Zeitalter&apos;&apos; in der Physik des 20. Jahrhunderts. Auf der Grundlage der Dokumente aus seinem Leben und Wirken, d.h. der Urkunden, Briefe und Berichte von Zeitzeugen sowie der publizierten und unpublizierten Abhandlungen, Buecher und Artikel Heisenbergs - auch der spaeter aufgefundenen, ueberwiegend aus dem Nachlass Heisenbergs stammenden Veroeffentlichungen oder

Why Germany&apos;s &apos;Messy&apos; energy transition should be a lesson to other nations

Energy Technology Data Exchange (ETDEWEB)

Shepherd, John [nuclear 24, Brighton (United Kingdom)

2015-03-15

Germany&apos;s so-called &apos;&apos;energy transition&apos;&apos; (&apos;'Energiewende'&apos;) is increasingly drawing the intention of the international community - but it seems for all the wrong reasons. US Senator Lamar Alexander said recently that German energy policy is one of the reasons the US should not abandon nuclear, but actually encourage increased investment in nuclear power plants. Alexander&apos;s remarks were made in an article published by the US Nuclear Energy Institute, in which he outlined his reasons why the US should not follow Germany&apos;s lead. Alexander rightly pointed out that the cost of attempting to replace nuclear power with wind, solar, and accompanying infrastructure is estimated by the German government at some 1.2 trillion US dollars (about 1 trillion Euros). The senator also made the point that Germany &apos;&apos;does not produce enough reliable, baseload energy for an important manufacturing economy&apos;&apos;. He also expressed concern at Germany&apos;s reliance on buying natural gas from Russia. While Germany has been forcing the closure of nuclear power plants others, including the oil-rich United Arab Emirates (UAE), have been investing in new nuclear, Alexander said. Judging from Alexander&apos;s remarks, it seems that Germany&apos;s energy transition experience will, after all, have a long-lasting legacy. That legacy will be a valuable lesson to other major industrialised nations in why they should not follow Germany&apos;s lead in abandoning a sensible energy mix, if they wish to maintain and develop economic and industrial productivity while keeping to international commitments to tackle climate change.

Proposal of a simple screening method for a rapid preliminary evaluation of &apos;&apos;heavy metals&apos;&apos; mobility in soils of contaminated sites

Energy Technology Data Exchange (ETDEWEB)

Pinto, Valentina; Chiusolo, Francesca; Cremisini, Carlo [ENEA - Italian Agency for New Technologies, Energy and Environment, Rome (Italy). Section PROTCHIM

2010-09-15

Risks associated to &apos;&apos;heavy metals&apos;&apos; (HM) soil contamination depend not only on their total content but, mostly, on their mobility. Many extraction procedures have been developed to evaluate HM mobility in contaminated soils, but they are generally time consuming (especially the sequential extraction procedures (SEPs)) and consequently applicable on a limited number of samples. For this reason, a simple screening method, applicable even &apos;&apos;in field&apos;&apos;, has been proposed in order to obtain a rapid evaluation of HM mobility in polluted soils, mainly focused on the fraction associated to Fe and Mn oxide/hydroxides. A buffer solution of trisodium citrate and hydroxylamine hydrochloride was used as extractant for a single-step leaching test. The choice of this buffered solution was strictly related to the possibility of directly determining, via titration with dithizone (DZ), the content of Zn, Cu, Pb and Cd, which are among the most representative contaminants in highly mineralised soils. Moreover, the extraction solution is similar, aside from for the pH value, which is the one used in the BCR SEP second step. The analysis of bivalents ions through DZ titration was exploited in order to further simplify and quicken the whole procedure. The proposed method generically measures, in few minutes, the concentration of total extractable &apos;&apos;heavy metals&apos;&apos; expressed as molL{sup -1} without distinguishing between elements. The proposed screening method has been developed and applied on soil samples collected from rural, urban and mining areas, representing different situation of soil contamination. Results were compared with data obtained from the BCR procedure. The screening method demonstrated to be a reliable tool for a rapid evaluation of metals mobility. Therefore, it could be very useful, even &apos;&apos;in field&apos;&apos;, both to guide the sampling activity on site and to monitor the efficacy of the subsequent

Children&apos;s exposure to indoor air in urban nurseries-part I: CO2 and comfort assessment

International Nuclear Information System (INIS)

Branco, P.T.B.S.; Alvim-Ferraz, M.C.M.; Martins, F.G.; Sousa, S.I.V.

2015-01-01

Indoor air quality (IAQ) in nurseries is an emerging case-study. Thus, this study, as the Part I of the larger study “Children&apos;s exposure to indoor air in urban nurseries”, aimed to: i) evaluate nurseries’ indoor concentrations of carbon dioxide (CO 2 ), a global IAQ indicator, in class and lunch rooms; ii) assess indoor comfort parameters–temperature (T) and relative humidity (RH); and iii) analyse them according to guidelines and references for IAQ, comfort and children&apos;s health. Indoor continuous measurements were performed. Non-compliances with guidelines were found in comfort parameters, which could cause discomfort situations and also microbial proliferation. Exceedances in CO 2 concentrations were also found and they were caused by poor ventilation and high classroom occupation. More efficient ventilation and control of comfort parameters, as well as to reduce occupation by reviewing Portuguese legislation on that matter, would certainly improve IAQ and comfort in nurseries and consequently safeguard children&apos;s health. - Highlights: • High occupation and poor ventilation were main determinants of IAQ in nurseries. • T and RH indoor values found in nurseries are likely to cause thermal discomfort. • Building characteristics and an inadequate ventilation determined T and RH values. • High CO 2 concentrations found could indicate accumulation of other air pollutants

Aharonov-Bohm effect for a fermion field in a planar black hole &apos;'spacetime'&apos;

Energy Technology Data Exchange (ETDEWEB)

Anacleto, M.A.; Mohammadi, A. [Universidade Federal de Campina Grande, Departamento de Fisica, Caixa Postal 10071, Campina Grande, Paraiba (Brazil); Brito, F.A. [Universidade Federal de Campina Grande, Departamento de Fisica, Caixa Postal 10071, Campina Grande, Paraiba (Brazil); Universidade Federal da Paraiba, Departamento de Fisica, Caixa Postal 5008, Joao Pessoa, Paraiba (Brazil); Passos, E. [Universidade Federal de Campina Grande, Departamento de Fisica, Caixa Postal 10071, Campina Grande, Paraiba (Brazil); Universidade Federal do Rio de Janeiro, Instituto de Fisica, Caixa Postal 21945, Rio de Janeiro (Brazil)

2017-04-15

In this paper we consider the dynamics of a massive spinor field in the background of the acoustic black hole spacetime. Although this effective metric is acoustic and describes the propagation of sound waves, it can be considered as a toy model for the gravitational black hole. In this manner, we study the properties of the dynamics of the fermion field in this &apos;'gravitational'&apos; rotating black hole as well as the vortex background. We compute the differential cross section through the use of the partial wave approach and show that an effect similar to the gravitational Aharonov-Bohm effect occurs for the massive fermion field moving in this effective metric. We discuss the limiting cases and compare the results with the massless scalar field case. (orig.)

Evaluation of Semon&apos;s Law in Laryngeal Paralysis

Directory of Open Access Journals (Sweden)

J. Hedayaty

1957-01-01

Full Text Available We have discussed hi t . ] . IS orica and clinical aspects of Semon&apos;s L concernIng the hevaviOur of the vocal cords&apos; aw net ve paralysis and the exist&apos; diff In the recurrent laryngeal Althou h &apos; mg I erent theories for its explanation. g One may fwd certain truth in neverthless, it seemsfl&apos; SOmeof the old theories, ar more ogical and satisfactor the explanation of th S &apos;L y to us to search e ernon s aw throu h the anatomy of the SU . I g Our new knowledge of penor aryngeal nerve in man d i which innervate the .t&apos; an ItS motor fibers In erarytenOld muscle.

Design Concept of a Seal-off Type 14 MeV Neutron Generator of 10&apos;&apos;1&apos;&apos;1n/s Range

Energy Technology Data Exchange (ETDEWEB)

In, S. R.; Oh, B. H. [KAERI, Daejeon (Korea, Republic of)

2015-05-15

The total neutron fluence during the life time is expected to be around 10MW·yr/m&apos;&apos;2 which may cause a damage of -100 dpa in materials. To estimate the adaptability of candidate materials in a few years, a 14MeV neutron source with a flux level of 3 - 5 x 10&apos;&apos;1&apos;&apos;8 n/s·m&apos;&apos;2, which is the goal of the IFMIF facility costing more than ¤1000M, is necessitated. The problem in making an intense neutron generator of beam target type is really not on the neutron production rate, but on the huge heat generated in the target, because the fusion power is only one of thousands of beam power exerted on the target. We have a plan to develop neutron generators step by step from a 10&apos;&apos;8 n/s level. The final goal is establishing a 14MeV neutron irradiation facility at 10&apos;&apos;1&apos;&apos;4 intensity level.. Up to the 10&apos;&apos;1&apos;&apos;0 n/s level, there occurs basically no critical thermal problem, because beam power density is in the range of tens W/cm&apos;&apos;2. The neutron generator designed in a sealed-off type because of tritium safety is mainly composed of an ion source, target, reaction chamber, and getter pump.. The major design concepts for the neutron generator with the neutron production rate of 10&apos;&apos;1&apos;&apos;1 n/s range were presented. The specifications of the ion source, target and getter have been determined for attaining the goal of the neutron generation rate.

IMB2026791, a Xanthone, Stimulates Cholesterol Efflux by Increasing the Binding of Apolipoprotein A-I to ATP-Binding Cassette Transporter A1

Directory of Open Access Journals (Sweden)

Zijian Xie

2012-03-01

Full Text Available It is known that the ATP-binding cassette transporter A1 (ABCA1 plays a major role in cholesterol homeostasis and high density lipoprotein (HDL metabolism. Several laboratories have demonstrated that ABCA1 binding to lipid-poor apolipoprotein A-I (apoA-I will mediate the assembly of nascent HDL and cellular cholesterol efflux, which suggests a possible receptor-ligand interaction between ABCA1 and apoA-I. In this study, a cell-based-ELISA-like high-throughput screening (HTS method was developed to identify the synthetic and natural compounds that can regulate binding activity of ABCA1 to apoA-I. The cell-based-ELISA-like high-throughput screen was conducted in a 96-well format using Chinese hamster ovary (CHO cells stably transfected with ABCA1 pIRE2-EGFP (Enhanced Green Fluorecence Protein expression vector and the known ABCA1 inhibitor glibenclamide as the antagonist control. From 2,600 compounds, a xanthone compound (IMB 2026791 was selected using this HTS assay, and it was proved as an apoA-I binding agonist to ABCA1 by a flow cytometry assay and western blot analysis. The [3H] cholesterol efflux assay of IMB2026791 treated ABCA1-CHO cells and PMA induced THP-1 macrophages (human acute monocytic leukemia cell further confirmed the compound as an accelerator of cholesterol efflux in a dose-dependent manner with an EC50 of 25.23 μM.

XVII International Scientific Conference &apos;&apos;RESHETNEV READINGS&apos;&apos;

International Nuclear Information System (INIS)

2015-01-01

The International Scientific Conference &apos;RESHETNEV READINGS&apos; is dedicated to the memory of Mikhail Reshetnev, an outstanding scientist, chief-constructor of space-rocket systems and communication satellites. The current volume represents selected proceedings of the main conference materials which were published by XVII International Scientific Conference &apos;RESHETNEV READINGS&apos; held on November 12 – 14, 2013. Plenary sessions, round tables and forums will be attended by famous scientists, developers and designers representing the space technology sector, as well as professionals and experts in the IT industry. A number of outstanding academic figures expressed their interest in an event of such a level including Jaures Alferov, Vice-president of the Russian Academy of Sciences (RAS), Academician of RAS, Nobel laureate, Dirk Bochar, General Secretary of the European Federation of National Engineering Associates (FEANI), Prof. Yuri Gulyaev, Academician of RAS, Member of the Presidium of RAS, President of the International Union of Scientific and Engineering Associations, Director of the Institute of Radio Engineering and Electronics of RAS, as well as rectors of the largest universities in Russia, chief executives of well-known research enterprises and representatives of big businesses. We would like to thank our main sponsors such as JSC &apos;&apos;Reshetnev Information Satellite Systems&apos;&apos;, JSC &apos;&apos;Krasnoyarsk Engineering Plant&apos;&apos;, Central Design Bureau &apos;'Geophysics'&apos;, Krasnoyarsk Region Authorities. These enterprises and companies are leading ones in the aerospace branch. It is a great pleasure to cooperate and train specialists for them. (preface)

Spectrofluorometric determination of intracellular levels of reactive oxygen species in drug-sensitive and drug-resistant cancer cells using the 2&apos;,7&apos;-dichlorofluorescein diacetate assay

Energy Technology Data Exchange (ETDEWEB)

Loetchutinat, Chatchanok [Laboratory of Physical Chemistry, Molecular and Cellular Biology, Faculty of Science, Burapha University, Bangsaen, Chonburi 20131 (Thailand); Kothan, Suchart [Laboratory of Physical Chemistry, Molecular and Cellular Biology, Faculty of Science, Burapha University, Bangsaen, Chonburi 20131 (Thailand); Dechsupa, Samarn [Laboratory of Physical Chemistry, Molecular and Cellular Biology, Faculty of Science, Burapha University, Bangsaen, Chonburi 20131 (Thailand); Meesungnoen, Jintana [Laboratory of Physical Chemistry, Molecular and Cellular Biology, Faculty of Science, Burapha University, Bangsaen, Chonburi 20131 (Thailand); Departement de medecine nucleaire et de radiobiologie, Faculte de medecine, Groupe en sciences des radiations, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4 (Canada); Jay-Gerin, Jean-Paul [Departement de medecine nucleaire et de radiobiologie, Faculte de medecine, Groupe en sciences des radiations, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4 (Canada); Mankhetkorn, Samlee [Laboratory of Physical Chemistry, Molecular and Cellular Biology, Faculty of Science, Burapha University, Bangsaen, Chonburi 20131 (Thailand)]. E-mail: samlee@bucc4.buu.ac.th

2005-02-01

This article examines a non-invasive spectrofluorometric method using the 2&apos;,7&apos;-dichlorofluorescein diacetate (DCHF-DA) assay for quantifying the intracellular reactive oxygen species (ROS{sub i}) produced in four cultured cancer cell lines: drug-sensitive (K562) and drug-resistant (K562/adr) human erythromyelogenous leukemia cell lines, and drug-sensitive (GLC4) and drug-resistant (GLC4/adr) human small cell lung carcinoma cell lines. The oxidation of the probe to the fluorescent dichlorofluorescein (DCF) was continuously monitored by following the DCF fluorescence intensity as a function of time using a standard spectrofluorometer in the presence of an extracellular DCF fluorescence quencher (Co{sup 2+}). By fitting the spectrofluorometric data to a kinetic model based on the following two reactions: (i) deacetylation of DCHF-DA to the oxidant-sensitive compound 2&apos;,7&apos;-dichlorofluorescein (DCHF) by cellular esterase enzymes (pseudo-first-order rate constant: k{sub e}) and (ii) oxidation of DCHF by ROS{sub i} (second-order rate constant: k{sub 2}), the parameters intervening in DCF formation, k{sub e} and the product of k{sub 2} by the ROS{sub i} concentration, were quantitatively determined for the different cell lines studied. The results revealed that the intracellular esterase content or activity is similar in K562, K562/adr, and GLC4 cells, but 5-fold higher in GLC4/adr cells. The product k{sub 2}[ROS{sub i}] was found to be similar in the four cell lines considered, with a mean value of (5.3+/-0.9)x10{sup -7}cell{sup -1}s{sup -1}. Assuming that H{sub 2}O{sub 2} (in combination with peroxidases) is the primary responsible species for DCHF oxidation in intact cells, and using the rate constant value k2=790+/-62M-1s-1 established in our laboratory for the reaction of DCHF with H{sub 2}O{sub 2} in the presence of horseradish peroxidase, the mean value of the intracellular levels of ROS{sub i} in those cells was estimated to be 0.67+/-0.16n

Synthesis, in vitro pharmacologic characterization, and preclinical evaluation of N-[2-(1&apos;-piperidinyl)ethyl]-3-[{sup 125}I]iodo-4-methoxybenzamide (P[{sup 125}I]MBA) for imaging breast cancer

Energy Technology Data Exchange (ETDEWEB)

John, Christy S. E-mail: radcsj@gwumc.edu; Bowen, Wayne D.; Fisher, Susan J.; Lim, Benjamin B.; Geyer, Brian C.; Vilner, Bertold J.; Wahl, Richard L

1999-05-01

The goal of this study was to investigate the potential use of a radioiodinated benzamide, N-[2-(1&apos;-piperidinyl)ethyl]-3-iodo[{sup 125}I]-4-methoxybenzamide (P[{sup 125}I]MBA), a sigma receptor binding radioligand for imaging breast cancer. The chemical and radiochemical syntheses of PIMBA are described. The pharmacological evaluation of PIMBA was carried out for sigma-1 and sigma-2 receptor sites. The in vivo pharmacokinetics of the radioiodinated benzamide were determined in rats and comparison of P[{sup 125}I]MBA with Tc-99m sestamibi were made in a rat mammary tumor model. Sigma-1 affinity (K{sub i}) for PIMBA in guinea pig brain membranes using [{sup 3}H](+)pentazocine was found to be 11.82{+-}0.68 nM, whereas sigma-2 affinity in rat liver using [{sup 3}H]DTG (1,3-o-di-tolylguanidine) was 206{+-}11 nM. Sites in guinea pig brain membranes labeled by P[{sup 125}I]MBA showed high affinity for haloperidol, (+)-pentazocine, BD1008, and PIMBA (K{sub i}=4.87{+-}1.49,8.81{+-}1.97,0.057{+-}0.005,46.9{+-}1.8 nM), respectively). Competition binding studies were carried out in human ductal breast carcinoma cells (T47D). A dose-dependent inhibition of specific binding was observed with several sigma ligands. K{sub i} values for the inhibition of P[{sup 125}I]MBA binding in T47D cells for haloperidol, N-[2-(1&apos;-piperidinyl)]ethyl]4-iodobenzamide (IPAB), N-(N-benzylpiperidin-4-yl)-4-iodobenzamide (4-IBP), and PIMBA were found to be 1.30{+-}0.07, 13{+-}1.5, 5.19{+-}2.3, 1.06{+-}0.5 nM, respectively. The in vitro binding data in guinea pig brain membranes and breast cancer cells confirmed binding to sigma sites. The saturation binding of P[{sup 125}I]MBA in T47D cells as studied by Scatchard analysis showed saturable binding, with a K{sub d}=94{+-}7 nM and a B{sub max}=2035{+-}305 fmol/mg of proteins. Biodistribution studies in Sprague-Dawley rats showed a rapid clearance of P[{sup 125}I]MBA from the normal organs. The potential of PIMBA in imaging breast cancer was

Data on gene and protein expression changes induced by apabetalone (RVX-208 in ex vivo treated human whole blood and primary hepatocytes

Directory of Open Access Journals (Sweden)

Sylwia Wasiak

2016-09-01

Full Text Available Apabetalone (RVX-208 inhibits the interaction between epigenetic regulators known as bromodomain and extraterminal (BET proteins and acetyl-lysine marks on histone tails. Data presented here supports the manuscript published in Atherosclerosis “RVX-208, a BET-inhibitor for Treating Atherosclerotic Cardiovascular Disease, Raises ApoA-I/HDL and Represses Pathways that Contribute to Cardiovascular Disease” (Gilham et al., 2016 [1]. It shows that RVX-208 and a comparator BET inhibitor (BETi JQ1 increase mRNA expression and production of apolipoprotein A-I (ApoA-I, the main protein component of high density lipoproteins, in primary human and African green monkey hepatocytes. In addition, reported here are gene expression changes from a microarray-based analysis of human whole blood and of primary human hepatocytes treated with RVX-208. Keywords: Bromodomain, BET proteins, BET inhibitor, RVX-208, JQ1, Vascular inflammation, ApoA-I, Apolipoprotein A-I, African green monkey, Primary human hepatocytes, Gene expression, Microarrays

&apos;&apos;House in park&apos;&apos; gold plated. Subsequent certification for the new office building; &apos;&apos;Haus im Park&apos;&apos; vergoldet. Nachtraegliche LEED-Zertifizierung fuer neues Buerogebaeude

Energy Technology Data Exchange (ETDEWEB)

Herzog, Kati; Wildhack, Alice [Bilfinger Berger AG, Mannheim (Germany). Abt. Nachhaltigkeit/Energieeffizienz

2011-07-01

In March 2011, the &apos;&apos;house in park&apos;&apos; received the signet LEED {sup registered} of the U.S. Green Building Council (Washington, North Carolina, U.S.A.) in &apos;'gold'&apos;. In general, it is the second German project that was awarded with &apos;'gold'&apos; in the certification version &apos;&apos;New Construction, version 2009&apos;&apos;. The special challenge: In the planning phase, no aspects relevant to planning and execution with regard to LEED were implemented. In total there are 15 LEED-certified buildings actually in Germany (worldwide: 7,894). 115 Projects are registered (worldwide: 23,238). The trend is increasing, both nationally as well as internationally.

The role of composting from the point of view of Agenda 21; Il ruolo del compostaggio nell&apos;ottica dell&apos;Agenda 21

Energy Technology Data Exchange (ETDEWEB)

Chierici, F.

1999-10-01

Agenda 21 is more and more often mentioned in debates and meetings dealing with environment, economy and development. How to actually make the aims enunciated in what is to be considered the next century programmatic document effective is, on the contrary, hardly outlined. The aim of this article is to help in making interaction between Agenda 21 and product reality more tangible and evident, specifically as far as composting is concerned. After an analytical description of the document, the points of contact between Agenda 21 and composting are identified: each one is highlighted through a rich bibliography. [Italian] L&apos;Agenda 21 e&apos; sempre piu&apos; spesso ricordata all&apos;interno dei dibattiti e degli incontri che trattano d&apos;ambiente, economia e sviluppo. I modi attraverso i quali contestualizzare in pratica gli obiettivi enunciati in quello che va considerato come il documento programmatico del prossimo secolo sono invece spesso solo tratteggiati. Quest&apos;articolo vuole essere percio&apos; un contributo per rendere piu&apos; tangibile e visibile l&apos;interazione esistente tra l&apos;Agenda 21 e la realta&apos; produttiva; nel caso specifico il compostaggio. Dopo una descrizione analitica del documento, sono individuati in modo formale i punti di contatto tra gli obiettivi dell&apos;Agenda 21 ed il compostaggio: ciascuno di loro e&apos; messo in evidenza facendo riferimento ad un&apos;ampia bibliografia.

The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus.

Directory of Open Access Journals (Sweden)

Yi Yang

Full Text Available Amyloid plaque has been reported in brain biopsies from patients with idiopathic normal-pressure hydrocephalus (iNPH and proposed as a significant feature of the pathophysiology. Presence of the apolipoprotein E ε4 (APOE ε4 allele is associated with increased risk of Alzheimer's disease (AD.To compare the distribution of APOE genotype in iNPH patients with an age-matched population-based control group and with Alzheimer's disease (AD patients.APOE genotype frequencies were determined in 77 iNPH patients (50 men and 27 women, mean age 71.7 years diagnosed with iNPH, a sample of 691 AD patients and 638 age-matched population controls (299 men and 339 women from the INTERGENE cohort.The APOE distribution did not differ significantly between the iNPH patients and the control population. The per e4-allele odds-ratio (OR of iNPH was given by OR = 0.90, 95% confidence interval (CI = (0.50, 1.60 that was considerably smaller than the per-allele OR of AD, OR = 5.34 (4.10, 7.00.The results suggest that the APOE-related risk of AD in patients with iNPH is not higher than in the general population.

&apos;'SMART'&apos; MULTIFUNCTIONAL POLYMERS FOR ENHANCED OIL RECOVERY

Energy Technology Data Exchange (ETDEWEB)

Charles McCormick; Andrew Lowe

2004-10-20

Herein we report the aqueous polymerization of acrylamide using reversible addition fragmentation chain transfer (RAFT) polymerization to perform a comprehensive study on the polymerization of acrylamide. More specifically, the effect of polymerization conditions on the polymerization kinetics, molecular weight control, and blocking ability were examined. With this in mind, it was necessary to prepare &apos;'A'&apos; block (corona of the micelle) from a hydrophilic monomer. The responsive &apos;'B'&apos; block present in the core will be disclosed in the next two reports.

Auger electron emitter against multiple myeloma - targeted endo-radio-therapy with {sup 125}I-labeled thymidine analogue 5-iodo-4&apos;-thio-2&apos;-deoxyuridine

Energy Technology Data Exchange (ETDEWEB)

Morgenroth, Agnieszka, E-mail: amorgenroth@ukaachen.de [Nuclear Medicine Clinic, University Ulm, Albert-Einstein-Allee 23, D-89081 Ulm (Germany); Nuclear Medicine Clinic, University Aachen, RWTH, Pauwelsstrasse 30, D-52074 Aachen (Germany); Dinger, Cornelia; Zlatopolskiy, Boris D.; Al-Momani, Ehab; Glatting, Gerhard [Nuclear Medicine Clinic, University Ulm, Albert-Einstein-Allee 23, D-89081 Ulm (Germany); Mottaghy, Felix M. [Nuclear Medicine Clinic, University Aachen, RWTH, Pauwelsstrasse 30, D-52074 Aachen (Germany); Reske, Sven N. [Nuclear Medicine Clinic, University Ulm, Albert-Einstein-Allee 23, D-89081 Ulm (Germany)

2011-10-15

Introduction: Multiple myeloma (MM) is a plasma cell malignancy characterized by accumulation of malignant, terminally differentiated B cells in the bone marrow. Despite advances in therapy, MM remains an incurable disease. Novel therapeutic approaches are, therefore, urgently needed. Auger electron-emitting radiopharmaceuticals are attractive for targeted nano-irradiation therapy, given that DNA of malignant cells is selectively addressed. Here we evaluated the antimyeloma potential of the Auger electron-emitting thymidine analogue {sup 125}I-labeled 5-iodo-4&apos;-thio-2&apos;-deoxyuridine ([{sup 125}I]ITdU). Methods: Cellular uptake and DNA incorporation of [{sup 125}I]ITdU were determined in fluorodeoxyuridine-pretreated KMS12BM, U266, dexamethasone-sensitive MM1.S and -resistant MM1.R cell lines. The effect of stimulation with interleukin 6 (IL6) or insulin-like growth factor 1 (IGF1) on the intracellular incorporation of [{sup 125}I]ITdU was investigated in cytokine-sensitive MM1.S and MM1.R cell lines. Apoptotic cells were identified using Annexin V. Cleavage of caspase 3 and PARP was visualized by Western blot. DNA fragmentation was investigated using laddering assay. Therapeutic efficiency of [{sup 125}I]ITdU was proven by clonogenic assay. Results: [{sup 125}I]ITdU was shown to be efficiently incorporated into DNA of malignant cells, providing a promising mechanism for delivering highly toxic Auger radiation emitters into tumor DNA. [{sup 125}I]ITdU had a potent antimyeloma effect in cell lines representing distinct disease stages and, importantly, in cell lines sensitive or resistant to the conventional therapeutic agent, but was not toxic for normal plasma and bone marrow stromal cells. Furthermore, [{sup 125}I]ITdU abrogated the protective actions of IL6 and IGF1 on MM cells. [{sup 125}I]ITdU induced massive damage in the DNA of malignant plasma cells, which resulted in efficient inhibition of clonogenic growth. Conclusion: These studies may provide a

Development and utilization of a mechanical barrier for large-calibre cavern necks. The &apos;&apos;Spider Plug&apos;&apos;; Entwicklung und Einsatz einer mechanischen Absperrung fuer grosskalibrige Kavernenhaelse. Der &apos;&apos;Spider Plug&apos;&apos;

Energy Technology Data Exchange (ETDEWEB)

Pfeifer, K.; Maut, D. [UGS GmbH, Mittenwalde (Germany)

2013-08-01

An hydraulic separation of a well and the cavern can be necessary for different workover applications, e.g. casing milling or underreaming. The separation is needed to ensure a mud circulation during such operations. In that case a barrier is set after flooding the cavern, which will then be used as a mechanical abutment for the cement bridge. If the diameter of the cavern neck has been enlarged due to e.g. unwanted leaching processes or unstabilized underreaming processes, it might get impossible to set a standard plug with the available technologies into those diameters. Therefore UGS GmbH has developed a mechanical plug, which is set hydraulically. The so called &apos;Spider Plug&apos; is used as basis for a cement bridge and can be removed by drilling after the workover has been done. Depending on the dimension of the setting tool a cavern neck up to 50&apos;&apos; diameter can be plugged by the &apos;Spider Plug&apos;. Up to now a number of successful operations on different locations has shown, that the &apos;Spider Plug&apos; is a practicable and cost-efficient solution for a mechanical abutment of large cavern necks. (orig.)

Accumulation of cyanobacterial toxins in freshwater &apos;seafood&apos; and its consequences for public health: A review

Energy Technology Data Exchange (ETDEWEB)

Ibelings, Bas W. [Eawag, Swiss Federal Institute of Aquatic Sciences and Technology, Centre of Ecology, Evolution and Biogeochemistry, Seestrasse 79, CH-6047 Kastanienbaum (Switzerland); Netherlands Institute of Ecology, Centre for Limnology, Rijksstraatweg 6, 3631 AC, Nieuwersluis (Netherlands)], E-mail: bas.ibelings@eawag.ch; Chorus, Ingrid [German Federal Environment Agency, Corrensplatz 1, 14195 Berlin (Germany)], E-mail: ingrid.chorus@uba.de

2007-11-15

This review summarizes and discusses the current understanding of human exposure to cyanobacterial toxins in &apos;seafood&apos; collected from freshwater and coastal areas. The review consists of three parts: (a) the existing literature on concentrations of cyanobacterial toxins in seafood is reviewed, and the likelihood of bioaccumulation discussed; (b) we derive cyanotoxin doses likely to occur through seafood consumption and propose guideline values for seafood and compare these to guidelines for drinking water; and (c) we discuss means to assess, control or mitigate the risks of exposure to cyanotoxins through seafood consumption. This is discussed in the context of two specific procedures, the food specific HACCP-approach and the water-specific Water Safety Plan approach by the WHO. Risks of exposure to cyanotoxins in food are sometimes underestimated. Risk assessments should acknowledge this and investigate the partitioning of exposure between drinking-water and food, which may vary depending on local circumstances. - Accumulation of cyanobacterial toxins in freshwater &apos;seafood&apos;.

The Public&apos;s Needs (a la Maslow) Drive the Public&apos;s Receptivity to Information

Energy Technology Data Exchange (ETDEWEB)

Cramer, E.N.

1999-11-14

The communication problem of the nuclear industry is the same as any other nonmonopoly provider of products or services, i.e., to show the public that nuclear electricity is superior even though nuclear electricity itself is indistinguishable from any other electricity. The public wants to know how nuclear compares with other sources of electricity in almost any other way except detailed information on the &apos;&apos;nuts and bolts&apos;&apos; of how electricity is made. They want to learn first, that there is an adequate supply of nuclear fuel and that they will not have to degrade their lifestyle unless they choose to do so; second, that they are safe and that meaningful consideration has been given to public safety for nuclear energy generation, including waste disposal; third, that this method is accepted by reputable scientists; fourth, that their use of this method is decreasing world societal problems, causes of war, and causes of pollution; and fifth, that this method increases their ability to accomplish the things that one&apos;s potential allows.

First monitoring report &apos;&apos;The future of the power&apos;&apos;; Erster Monitoring-Bericht &apos;&apos;Energie der Zukunft&apos;&apos;

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-12-15

The Federal Government has initiated the reconstruction of the energy supply towards a highly efficient and renewable energy systems using the energy concept from September, 2010, and using the energy political resolutions from June, 2011. The energy policy turnaround is ambitioned in its objectives as well as broadly defined. In order to consider the energy policy turnaround as well as the development of the energy market continuously, the Federal Government initiated the monitoring process &apos;&apos;Energy of the future&apos;&apos; with the aim to review regularly the implementation of the measures of the energy concepts as well as the progress in the goal achievement with a view on a secure, economical and environmentally compatible energy supply. The first monitoring report &apos;&apos;Energy of the future&apos;&apos; under consideration is the onset of this process. This report is an important basis for the current fact-based attendance of the energy policy turnaround.

Resonant light power buildup in ALPS, a &apos;&apos;light shining through a wall&apos;&apos;-experiment

Energy Technology Data Exchange (ETDEWEB)

Meier, Tobias; Danzmann, Karsten; Willke, Benno [Max-Planck-Institut fuer Gravitationsphysik, Albert Einstein Institut (Germany); Institut fuer Gravitationsphysik, Leibniz Universitaet Hannover, Callinstrasse 38, D-30167 Hannover (Germany); Ehret, Klaus; Ghazaryan, Samvel; Knabbe, Axel; Lindner, Axel; List, Jenny; Meyer, Niels; Notz, Dieter; Redondo, Javier; Ringwald, Andreas [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Frede, Maik; Hildebrandt, Matthias [Laserzentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover (Germany); Wiedemann, Guenter [Hamburger Sternwarte, Gojenbergsweg 112, D-21029 Hamburg (Germany)

2009-07-01

We report on the first successfull application of a new experimental technique to search for weakly interacting sub-eV particles (WISPs) coupling to photons. As part of the ALPS experiment located at DESY in Hamburg, this technique uses an optical resonator to enhance the power inside a HERA dipole magnet on the production side of a typical &apos;&apos;light shining through a wall&apos;&apos;-experiment. We use a frequency doubled continuous-wave laser emitting 0.6 W of power at 532 nm that is stabilized to a linear optical resonator with 8 m length. On resonance we achieve a circulating power of 34 W within the magnet. With this we obtained sensitivities corresponding to a coupling strength of g{approx}5.10{sup -7} GeV{sup -1} for interactions of axion-like particles and photons. The experimental setup and possible improvements are described and compared with common experimental designs with pulsed lasers.

Maintain levels of nicotine but reduce other smoke constituents: a formula for &apos;'less-hazardous'&apos; cigarettes

Energy Technology Data Exchange (ETDEWEB)

Robinson, J.C.; Young, J.C.; Rickert, W.S.

1984-09-01

Twenty-two volunteers who smoked more than 20 cigarettes with &apos;'high'&apos; nicotine yields (0.8 to 1.2 mg) per day participated in an 8-week study designed to test the hypothesis that smoking cigarettes with a constant level of nicotine but reduced deliveries of tar, carbon monoxide, and hydrogen cyanide leads to a decrease in smoke absorption. All subjects smoked their usual high-nicotine brand for the first 3 weeks (P1), and the absorption of smoke constituents was determined from levels of thiocyanate and cotinine in saliva and serum, levels of carbon monoxide in expired air, and levels of carboxyhemoglobin in the blood. During the final 5 weeks (P2), the treatment group (16 subjects) switched to the &apos;'light'&apos; version of their usual brands (similar yields of nicotine but with reduced yields of tar, carbon monoxide, and hydrogen cyanide); the control group (6 subjects) smoked their usual brands for the duration of the study. Average levels of cotinine for the subjects who switched during P2 were not significantly different from those of the control group as was expected. Slight reductions were noted in average expired-air carbon monoxide levels, blood carboxyhemoglobin, and saliva thiocyanate, but these reductions were smaller than anticipated based on brand characteristics. The results suggest that the ratio of smoke constituents is different when individuals, rather than machines, smoke cigarettes. Yields determined under subject-defined conditions are necessary in order to properly evaluate the role of nicotine in the design of &apos;'less-hazardous'&apos; cigarettes.

THE &apos;TWIN-CME&apos; SCENARIO AND LARGE SOLAR ENERGETIC PARTICLE EVENTS IN SOLAR CYCLE 23

Energy Technology Data Exchange (ETDEWEB)

Ding, Liuguan; Jiang, Yong [College of Math and Physics, Nanjing University of Information Science and Technology, Nanjing, Jiangsu 210044 (China); Zhao, Lulu; Li, Gang, E-mail: gang.li@uah.edu [Department of Physics and CSPAR, University of Alabama in Huntsville, AL 35899 (United States)

2013-01-20

Energetic particles in large solar energetic particle (SEP) events are a major concern for space weather. Recently, Li et al. proposed a &apos;twin-CME&apos; scenario for ground-level events. Here we extend that study to large SEP events in solar cycle 23. Depending on whether preceding coronal mass ejections (CMEs) within 9 hr exist and whether ions >10 MeV nucleon{sup -1} exceed 10 pfu, we categorize fast CMEs with speed >900 km s{sup -1} and width >60 Degree-Sign from the western hemisphere source regions into four groups: groups I and II are &apos;twin&apos; and single CMEs that lead to large SEPs; groups III and IV are &apos;twin&apos; and single CMEs that do not lead to large SEPs. The major findings of this paper are: first, large SEP events tend to be &apos;twin-CME&apos; events. Of 59 western large SEP events in solar cycle 23, 43 are &apos;twin-CME&apos; (group I) events and 16 are single-CME (group II) events. Second, not all &apos;twin CMEs&apos; produced large SEPs: 28 twin CMEs did not produce large SEPs (group III events). Some of them produced excesses of particles up to a few MeV nucleon{sup -1}. Third, there were 39 single fast CMEs that did not produce SEPs (group IV events). Some of these also showed an excess of particles up to a few MeV nucleon{sup -1}. For all four groups of events, we perform statistical analyses on properties such as the angular width, the speed, the existence of accompanying metric type II radio bursts, and the associated flare class for the main CMEs and the preceding CMEs.

Thyrotropin receptor antibody activities significantly correlate with the outcome of radioiodine ( sup 131 I) therapy for hyperthyroid Graves&apos; disease

Energy Technology Data Exchange (ETDEWEB)

Kaise, Kazuro; Kaise, Nobuko; Yoshida, Katsumi; Fukazawa, Hiroshi; Mori, Koki; Yamamoto, Makiko; Sakurada, Toshiro; Saito, Shintaro; Yoshinaga, Kaoru (Tohoku Univ., Sendai (Japan). School of Medicine)

1991-08-01

The outcome of {sup 131}I therapy for 109 patients with Graves&apos; disease was analysed according to pretreatment laboratory data including thyrotropin receptor antibody (TRAb) activities. Forty-five percent of patients became euthyroid, and 13% of patients became hypothyroid within one year after {sup 131}I therapy. Forty-two percent of patients remained hyperthyroid one year after {sup 131}I therapy. Pretreatment values for serum T{sub 4}, T{sub 3}, and the estimated weight of the thyroid were significantly higher in the hyperthyroid group. The mean for the TRAb index of the hyperthyroid group was significantly higher than that of the euthyroid group. Life table analysis revealed a significant effect of the TRAb index on the rate of hyperthyroidism after 3 months or later. These results appear to suggest that the TRAb index is one of the factors which influence the outcome of {sup 131}I therapy for Graves&apos; disease. (author).

Sex differences in HDL ApoC-III in American Indian youth

Directory of Open Access Journals (Sweden)

Blackett Piers R

2012-08-01

Full Text Available Abstract Background Since American Indians are predisposed to type 2 diabetes (DM2 and associated cardiovascular risk, Cherokee boys and girls (n = 917 were studied to determine whether BMI Z (body mass index Z score is associated with the apoC-III (apolipoprotein C-III content of HDL (high density lipoprotein, a previously reported predictor of DM2. Methods An ad hoc cross-sectional analysis was conducted on a previously studied cohort. Participants were grouped by gender-specific age groups (5 to 9, 10 to 14 and 15 to 19 years. ApoA-I (apolipoprotein A-I and HDL apoC-III were assayed by electroimmunoassay. ApoC-III was measured in whole plasma, and in HDL to determine the molar proportion to apoA-I. General linear models were used to assess association. Results The HDL apoC-III to apoA-I molar ratio increased by BMI Z quartile in girls aged 10–14 years (p  Conclusions ApoC-III showed an obesity-related increase relative to apoA-I during adolescence beginning in girls aged 10 to 14 years and in boys aged 15 to 19 years. The earlier changes in girls may alter HDL’s protective properties on the β-cell and contribute to their increased risk for DM2.

Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription

Energy Technology Data Exchange (ETDEWEB)

Kusano, Shuichi, E-mail: skusano@m2.kufm.kagoshima-u.ac.jp [Division of Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Eizuru, Yoshito [Division of Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan)

2010-06-04

Kaposi&apos;s sarcoma-associated herpes virus (KSHV)-encoded latency-associated nuclear antigen (LANA) protein has been reported to interact with glycogen synthase kinase 3{beta} (GSK-3{beta}) and to negatively regulate its activity, leading to stimulation of GSK-3{beta}-dependent {beta}-catenin degradation. We show here that the I-mfa domain proteins, HIC (human I-mfa domain-containing protein) and I-mfa (inhibitor of MyoD family a), interacted in vivo with LANA through their C-terminal I-mfa domains. This interaction affected the intracellular localization of HIC, inhibited the LANA-dependent transactivation of a {beta}-catenin-regulated reporter construct, and decreased the level of the LANA.GSK-3{beta} complex. These data reveal for the first time that I-mfa domain proteins interact with LANA and negatively regulate LANA-mediated activation of Wnt signaling-dependent transcription by inhibiting the formation of the LANA.GSK-3{beta} complex.

&apos;On the Uses and Disadvantages of History&apos; for Radioactive Waste Management

Energy Technology Data Exchange (ETDEWEB)

Laes, Erik (Flemish Inst. for Technological Research (VITO)/Univ. of Antwerp, Div. Transition Energy and Environment, Mol (Belgium)), e-mail: erik.laes@vito.be; Schroeder, Jantine (Belgian Nuclear Research Centre (SCK-CEN), Society and Policy Support unit, Mol (Belgium))

2010-09-15

In this paper we propose a critical investigation of the founding assumptions for the legitimacy of the (internationally accepted) geological disposal option through a reading of Nietzsche&apos;s second untimely meditation &apos;On the uses and disadvantages of history for life&apos;. In particular, we propose an interpretation of some of the central concepts in this text - History, the present, discourses and attitudes towards the past, etc. - and investigates in particular the effects of the confrontation between the Nietzschean concept of &apos;active forgetting&apos; and present practices in the management of medium- and high-level long-lived radioactive waste (cat. B and C). Furthermore, we argue that this untimely meditation comes at a timely moment, i.e. at a time when modernity&apos;s way of dealing with waste could be undergoing a major transformation. The paper ends with some reflections on our nuclear inheritance and its link with nuclear power of the future (Gen IV) inspired by Nietzsche

Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans.

Science.gov (United States)

Graham, Mark J; Lee, Richard G; Bell, Thomas A; Fu, Wuxia; Mullick, Adam E; Alexander, Veronica J; Singleton, Walter; Viney, Nick; Geary, Richard; Su, John; Baker, Brenda F; Burkey, Jennifer; Crooke, Stanley T; Crooke, Rosanne M

2013-05-24

Elevated plasma triglyceride levels have been recognized as a risk factor for the development of coronary heart disease. Apolipoprotein C-III (apoC-III) represents both an independent risk factor and a key regulatory factor of plasma triglyceride concentrations. Furthermore, elevated apoC-III levels have been associated with metabolic syndrome and type 2 diabetes mellitus. To date, no selective apoC-III therapeutic agent has been evaluated in the clinic. To test the hypothesis that selective inhibition of apoC-III with antisense drugs in preclinical models and in healthy volunteers would reduce plasma apoC-III and triglyceride levels. Rodent- and human-specific second-generation antisense oligonucleotides were identified and evaluated in preclinical models, including rats, mice, human apoC-III transgenic mice, and nonhuman primates. We demonstrated the selective reduction of both apoC-III and triglyceride in all preclinical pharmacological evaluations. We also showed that inhibition of apoC-III was well tolerated and not associated with increased liver triglyceride deposition or hepatotoxicity. A double-blind, placebo-controlled, phase I clinical study was performed in healthy subjects. Administration of the human apoC-III antisense drug resulted in dose-dependent reductions in plasma apoC-III, concomitant lowering of triglyceride levels, and produced no clinically meaningful signals in the safety evaluations. Antisense inhibition of apoC-III in preclinical models and in a phase I clinical trial with healthy subjects produced potent, selective reductions in plasma apoC-III and triglyceride, 2 known risk factors for cardiovascular disease. This compelling pharmacological profile supports further clinical investigations in hypertriglyceridemic subjects.

Investigation of vertebral &apos;&apos;end plate sclerosis&apos;&apos;

Energy Technology Data Exchange (ETDEWEB)

Lee, S.W. [Dept. of Rehabilitation Sciences, Hong Kong Polytechnic Univ., Hung Hom (Hong Kong); Mathie, A.G.; Jackson, J.E. [Diagnostic Radiology, Royal Postgraduate Medical School, Hammersmith Hospital, London (United Kingdom); Hughes, S.P.F. [Div. of Surgery, Anaesthetics and Intensive Care, London (United Kingdom)

2001-08-01

To evaluate the association between vertebral &apos;&apos;end plate sclerosis&apos;&apos; and neck pain. A retrospective study was carried out of lateral cervical spine radiographs with a Picture Archive and Communication System (PACS). Two hundred patients&apos; files were randomly assessed, comprising four equal groups, A to D. The mean ages of the patients were 62{+-}7.4 years, 61{+-}7.5 years, 40{+-}5.6 years and 23{+-}5.6 years respectively. In group A, all patients had symptoms of neck pain and a radiographic diagnosis of &apos;&apos;end plate sclerosis&apos;&apos; of the cervical spine. In groups B to D, asymptomatic patients were recruited and their age groups were 50-69, 30-49 and 10-29 years respectively. Using the PACS, the radiographic density and the sagittal diameter, thickness and area of the end plates at the C5 level were measured. Results and conclusions: No significant differences were found in the radiographic density of the end plates either between the symptomatic and asymptomatic groups (groups A and B), or between different age groups (groups B, C and D). A significant increase in end plate area and thickness was found, however, in both group B (P<0.005) and group C (P<0.01) in comparison with group D. This indicates that the extent of end plate sclerosis increases with age. Our results suggest that the radiographic density of cervical vertebral end plates correlates neither with neck pain nor with increasing age. The radiological sign of &apos;&apos;end plate sclerosis&apos;&apos; may be over-reported, further limiting its value in the assessment of patients with cervical spondylosis. (orig.)

The Novel SCN&apos;&apos;- Ion-selective Electrode Based on the 1-Benzyl-3-(4-nitrophenyl) thio-urea Ionophore

Energy Technology Data Exchange (ETDEWEB)

Lee, Kyung Mi; Kang, Dong Hyeon; Choe, Ju Eun; You, Jung Min; Go, Min Jeong; Lee, Jung Seong; Jeon, Seung Won [Chungnam National University, Daejeon (Korea, Republic of)

2014-09-15

A potentiometric sensor based on the 1-benzyl-3-(4-nitrophenyl) thio-urea was synthesized and tested as an ionophore in PVC based membrane sensor towards SCN - ions. This membrane exhibits a linear stable response over a wide concentration range (1.0 × 10&apos;&apos;-5 to 1.0 × 10&apos;&apos;-2 M) with a slope of -59.2 mV/dec., a detection limit of log[SCN&apos;&apos;- ] = -5.05, and a selectivity coefficient for thiocyanate against perchlorate anion of logK{sub s}cn&apos;&apos;pot = -0.133. The selectivity series of the membrane is as follows: SCN&apos;&apos;- > ClO{sub 4}&apos;&apos;- > I'&apos;- >NO{sub 3}&apos;&apos;- >HSO{sub 3}&apos;&apos;- > Cl&apos;&apos;-HSO{sub &apos;}'-'&apos;4 > F&apos;&apos;- > CH{sub 3}COO&apos;&apos;- > HCO&apos;'-'&apos;3 > Br&apos;&apos;- > H{sub 2}PO{sub 4}&apos;&apos;- > SO{sub 3}&apos;'-'&apos;2 > SO{sub 4}&apos;'-'&apos;2 > CO{sub 3}&apos;'-'&apos;2. The proposed electrode showed good selectivity and a good response for the SCN&apos;&apos;- ion over a wide variety of other anions in pH 6.0 buffer solutions and has a fast response time of about < 5s.. The influences of the membrane by pH, ionophore, and plasticizer were studied.

Waste treatment in a systems perspective - Summary report -; Systemstudie Avfall - Sammanfattning - Sammanfattning av huvudresultat fraan projektet &apos;Termisk och biologisk avfallsbehandling i ett systemperspektiv&apos;

Energy Technology Data Exchange (ETDEWEB)

Sundberg, Johan; Bisaillon, Mattias; Haraldsson, Maarten; Norrman Eriksson, Ola; Sahlin, Jenny; Nilsson, Karolina

2010-07-01

The report &apos;Waste treatment in a systems perspective - Summary report&apos; summarizes the main results from the studies made within the research project &apos;Thermal and biological treatment in a systems perspective&apos;. The aim of the project is to develop tools and methodologies for systems analysis of waste management. The tools are used to evaluate waste treatment technologies for both household waste and commercial waste in a systems perspective. The focus is set to the municipal/regional waste and district heating system. However, to generate a full system analysis it is also important to consider effects that occur in the systems environment, such as the transport sector, the electricity production system, the agricultural sector etc. The report describes the benefits of using systems models for waste management planning by illustrating interesting results from the case studies made within the framework of the project. The report also presents the outcome from the whole project on an aggregated level as well as how the results and models have been used in different spin off projects. More thorough descriptions of models, methodologies and results are given in the reports for the two case studies, mainly. These reports presents two different case studies for municipal/regional waste management systems and are published by Waste Refinery, &apos;A systems study of the waste management system in Gothenburg&apos; and &apos;A systems study of the waste management system in Boraas&apos;. The models and methodology developed in the research project has been used in several &apos;spin-off projects&apos;. Some of the main results of these studies will be presented in this report, together with references to more extensive descriptions. We can conclude, after these three years of research, that the results from the system studies have been used for the practical waste management planning in both Boraas and Gothenburg. The models and the results from the two

Scoping Meeting Summary, Kaunakakai, Moloka&apos;i, March 12, 1992, 2 PM Session

Energy Technology Data Exchange (ETDEWEB)

Quinby-Hunt, Mary S.

1992-06-01

The meeting began with presentations by the facilitator, Mr. Spiegel, and Dr. Lewis, the program manager from DOE. The facilitator introduced those on the podium. He then described the general structure of the meeting and its purpose: to hear the issues and concerns of those present regarding the proposed Hawaiian Geothermal Project. He described his role as assuring the impartiality and fairness of the meeting. Dr. Lewis of DOE further defined the scope of the project, introduced members of the EIS team, and briefly described.the EIS process. The overwhelming concerns of the meeting were Native Hawaiian issues. The presenters [more than 70%, most of whom addressed no other issue] want the EIS to respect Native Hawaiian religion, race, rights, language, and culture, noting that they believe that geothermal development is a desecration of Pele [{approx}60% of all presenters]. They expressed concern that their ancestors and burials should not be desecrated. The EIS should address Native Hawaiian concerns that the HGP would negatively impact Native Hawaiian fisheries, subsistence lifestyles, and religious practices. Virtually all the speakers expressed frustration with government. Most (> 70%) of the speakers voiced concern and frustration regarding lack of consideration for Native Hawaiians by government and lack of trust in government. One commenter requested that the EIS should consider the international implications of the U.S allowing their rainforests to be cleared, when the U.S. government asks other nations to preserve theirs. Nearly 30% of the commenters want the EIS to address the concern that people on Moloka&apos;i will bear major environmental consequences of the HGP, but not gain from it. The commenters question whether it is right for Moloka&apos;i to pay for benefits to Oahu, particularly using an unproven technology. After questioning the reliability and feasibility of the marine cable:, nearly 30% of the presenters were concerned about the impacts of

Development of Patients&apos; Decision Aid for Older Women With Stage I Breast Cancer Considering Radiotherapy After Lumpectomy

Energy Technology Data Exchange (ETDEWEB)

Wong, Jennifer [Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); D' Alimonte, Laura [Department of Radiation Therapy, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Angus, Jan [Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario (Canada); Paszat, Larry [Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Metcalfe, Kelly [Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario (Canada); Whelan, Tim [Department of Radiation Oncology, Juravinski Cancer Centre, McMaster University, Hamilton, Ontario (Canada); Llewellyn-Thomas, Hilary [Department of Community and Family Medicine, The Center of Informed Choice, The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, NH (Lebanon); Warner, Eiran [Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Franssen, Edmee [Consultant Statistician, Faculty of Medicine, University of Toronto, Toronto, Ontario (Canada); Szumacher, Ewa, E-mail: Ewa.Szumacher@sunnybrook.ca [Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada)

2012-09-01

Purpose: To develop a patient decision aid (PtDA) for older women with Stage I, pathologically node negative, estrogen receptor-positive progesterone receptor-positive breast cancer who are considering adjuvant radiotherapy after lumpectomy and to examine its impact on patients&apos; decision making. Methods and Materials: A PtDA was developed and evaluated in three steps according to the Ottawa Decision Support Framework: (1) needs assessment (n = 16); (2) Pilot I to examine PtDA acceptability (n = 12); and (3) Pilot II, a pretest posttest (n = 38) with older women with estrogen receptor-positive progesterone receptor-positive breast cancer after lumpectomy who were receiving adjuvant radiation therapy. Measures included patients&apos; satisfaction with the PtDA, self-reported decisional conflict, level of distress, treatment-related knowledge, and choice predisposition. Results: The PtDA is a booklet that details each adjuvant treatment option&apos;s benefits, risks, and side effects tailored to the patient&apos;s clinical profile; includes a values clarification exercise; and includes steps to guide patients towards their decision. On the basis of qualitative comments and satisfaction ratings, all women thought that the PtDA was helpful and informative. In comparison with their baseline scores, patients had a statistically significant (p < 0.05) reduction in decisional conflict (adjusted mean difference [AMD], -7.18; 95% confidence interval [CI], -13.50 to 12.59); increased clarity of the benefits and risks (AMD, -10.86; CI, -20.33 to 21.49); and improved general treatment knowledge (AMD, 8.99; CI, 2.88-10.28) after using the PtDA. General trends were also reported in the patients&apos; choice predisposition scores that suggested potential differences in treatment decision after PtDA use. Conclusions: This study provides evidence that this PtDA may be a helpful educational tool for this group of women. The quality of care for older breast cancer patients may be

Asperger&apos;s in the Holmes Family

Science.gov (United States)

Altschuler, Eric L.

2013-01-01

I show that Mycroft Holmes (Sherlock Holmes&apos; brother) is a formally described case of Asperger&apos;s syndrome a half century before Asperger&apos;s description of the syndrome. Further, given the genetic similarity and links between the brothers stated by Sherlock, this also cinches the same diagnosis for Sherlock.

High-sensitivity gamma spectroscopy for extended sources. Application to activity measurements on the human body, on glass, and on soil; Spectrographie gamma a grande sensibilite pour sources etendues. Application a la mesure de l&apos;activite du corps humain, du verre et du sol

Energy Technology Data Exchange (ETDEWEB)

Jouve, B

1962-07-01

The measurement and location by gamma spectroscopy of human body internal contaminations at maximum permissible levels, and, in certain cases, at lower activities such as that due to {sup 40}K was investigated. The characteristics of the high-sensitivity apparatus used are given, and several assemblies using large-volume NaI(Tl) scintillators are described. The relatively light shielding required for natural radioactivity permitted construction of mobile assembly. Conditions of use are described, and the results are given. All gamma emitting elements were measured in 15 min at levels lower than the tolerance dose. Gamma spectroscopy was also used to determine fission products in the earth and to study radioactive elements in the presence of other emitters. (author) [French] La spectrographie gamma du corps humain permet la mesure et la localisation des contaminations internes au niveau des doses de tolerance et, dans certains cas, celle d&apos;activites plus faibles comme la radioactivite naturelle due principalement au potassium 40. Les caracteristiques des appareils a grande sensibilite permettant ces mesures sont exposees et on decrit plusieurs realisations originales utilisant un scintillateur NaI(Tl) de grand volume. L&apos;epaisseur du blindage a ete limitee a 5 cm de plomb, ainsi, pour une protection suffisante contre les rayonnements ambiants, les appareils sont relativement legers et l&apos;une des realisations a pu etre installee dans un laboratoire mobile. Les conditions d&apos;utilisation (mouvement propre, etalonnage) et les resultats obtenus sont donnes; tous les radioelements emetteurs gamma sont mesurables en 15 minutes a un niveau inferieur a la dose de tolerance. On presente enfin des applications a la spectrographie gamma d&apos;echantillons volumineux (poudres ou liquides) et de tres faible activite: elles interessent des domaines tres varies comme, par exemple, la geophysique (etude des retombees radioactives) ou l&apos;industrie chimique

&apos;K&apos; contribution to the biological effect of ionizing radiations

International Nuclear Information System (INIS)

Boissiere, Arnaud

2004-01-01

The aim of this work is to determine the importance of &apos;K&apos; ionizations on DNA as critical physical events initiating the biological effects of ionizing radiation, in particular in human cells. Ultra-soft X-rays are used as a probe of core ionization events. A decisive test consists in comparing the biological effects at 250 eV and 350 eV (before and after the carbon K - threshold). The results show a sharp increase of the biological efficiency for both cellular inactivation and chromosomal exchange aberration above the carbon K-threshold, correlated with the one of core events occurring in DNA atoms. The heavy ion irradiation displays again the paradoxical behaviour of cellular inactivation cross sections as a function of LET. Finally, the &apos;K&apos; event contribution to cellular inactivation of usual low LET radiation is estimated to be about 75%. (author) [fr

Comparison of PCDD/Fs levels and profiles in leachates from &apos;'new'&apos; and &apos;'old'&apos; municipal landfills

Energy Technology Data Exchange (ETDEWEB)

Dudzinska, M.; Czerwinski, J.; Rut, B. [Lublin Univ. of Technology (Poland)

2004-09-15

Although the presence of PCDD/Fs in landfill leachates has been confirmed, not many experiments have been undertaken in this area, probably because of a very low solubility of PCDD/Fs in water. Modern, properly designed landfills should secure (seal) all deposited wastes and possible leakings within the damp. Leachates are collected and treated on the site or transported to a wastewater treatment plant, so they should not cause a release of any pollutants into the soil or groundwater. But PCDD/Fs as well as a number of chlorinated compounds, which may act as precursors of dioxins under aerobic or anaerobic conditions have been identified as trace contaminants in municipal wastes. The formation of dioxins during municipal waste deposition has not been studied, contrary to the formation of OCDD from precursors under aerobic conditions during composting of waste or treatment of sewage sludge5. Some information about the possible dioxin formation during landfilling might be obtained from the comparison of PCDD/F levels in the leachates from &apos;&apos;old - closed&apos;&apos; and &apos;'new'&apos; sites.

Energy saving retrofitting of a prefabricated panel construction kinder-garden - demonstration project &apos;'Plappersnut'&apos; in Wismar.; Energetische Sanierung einer Kindertagesstaette in Plattenbauweise - Demonstrationsbauvorhaben &apos;'Plappersnut'&apos; in Wismar

Energy Technology Data Exchange (ETDEWEB)

Wollensak, Heidi [Institut fuer Gebaeude + Energie + Licht Planung, Alter Holzhafen 19, 23966 Wismar (Germany); Wollensak, Martin [Hochschule Wismar, FG Baukonstruktion und Baustofftechnik (Germany); Roemhild, Thomas [Hochschule Wismar, FG Entwerfen, Gebaeude- Klima- und Lichtplanung (Germany); Mainka, Georg-Wilhelm; Winkler, Heiko [Lehrstuhl fuer Baukonstruktionen und Bauphysik, Institut fuer Bauingenieurwesen, Universitaet Rostock (Germany)

2005-12-01

The project &apos;&apos;kindergarten Plappersnut&apos;&apos; in Wismar focuses on cutting the energy consumption of the in 1972 build prefabricated plate construction down to one third by mainly 3 means: - improving the relation between building volume and outside surface by replacing the corridor building between the two main wings with a light membrane roof, covering the whole space, - eliminating energy loss through the building structure by coating the whole building with different isolation systems, - replacing all of the technical installation under the aspects of ecological energy supply and energy retrieving systems. The project was classed as a demonstration project of the EnSan-Program, supported by the German Ministry for Economy and Technology. (Abstract Copyright [2005], Wiley Periodicals, Inc.) [German] Das Sanierungsprojekt der 1972 in Plattenbauweise errichteten Kita &apos;'Plappersnut'&apos; stand im Zeichen der Reduzierung des Energiebedarfs auf ein Drittel durch drei wesentliche Massnahmen: - Verbesserung des Verhaeltnisses Gebaeudevolumen zu Aussenwandflaeche durch Entfernung der Verbindungsgaenge zwischen beiden Gebaeudeteilen und Ueberdachung des entstehenden Hofes mit einem Membrandach, - Verminderung der Energieverluste durch die Gebaeudehuelle mit Hilfe verschiedener Waermedaemm-Massnahmen, - Ersatz der gesamten Gebaeudetechnik durch energiesparende Systeme und unter Einsatz von erneuerbaren Energien. Das Projekt wurde im Rahmen des EnSan-Programms vom Bundesministerium fuer Wirtschaft und Technologie gefoerdert. (Abstract Copyright [2005], Wiley Periodicals, Inc.)

On the universality of the &apos;'smile'&apos;-gap in the density of states of a chaotic Josephson junction

Energy Technology Data Exchange (ETDEWEB)

Reutlinger, Johannes; Belzig, Wolfgang [University of Konstanz, Department of Physics (Germany); Nazarov, Yuli [Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft (Netherlands); Glazman, Leonid [Department of Physics, Yale University, New Haven, CT (United States)

2015-07-01

The superconducting proximity effect strongly modifies the local density of states in chaotic Josephson junctions. Recently we found that besides the well-known minigap a secondary gap appears just below the superconducting gap edge Δ in the limit of a large Thouless energy E{sub Th} >or similar Δ. To check the universality of this novel gap phenomenon we study the effect of nonideal contacts and show that the &apos;'smile'&apos;-gap crucially depends on the transmission eigenvalue distribution. In a next step we use the random matrix method to investigate the &apos;'smile'&apos;-gap. This allows us to approach the statistics of Andreev levels, going beyond the quasiclassical Greens function method. It turns out that the hard gap edge softens similar to what is already known from the minigap.

Distributed technologies in California&apos;s energy future. Volume I

Energy Technology Data Exchange (ETDEWEB)

Christensen, M.; Craig, P.; McGuire, C.B.; Simmons, M. (eds.)

1977-09-01

This interim report contains eight of the eighteen chapters included in the complete report. In Chapter I, pertinent data, facts, and observations are made following an initial summary. Chapter II is an introduction, citing especially the writings of Amory Lovins. The criteria used in defining distributed systems, suggested by Lovins, are that the technologies be renewable, environmentally benign, local, subject to graceful failure, foolproof, flexible, comprehensible, and matched in energy quality. The following chapters are: The Energy Predicament; The California Setting; Energy Resources for California&apos;s Future; Alternative Energy Futures for California; Issues and Problems; and Directions for Future Work. Six appendices deal with residential heating loads and air conditioning, allocations, co-generation, population projections, and the California wind energy resource. (MCW)

Practice at P.S.A.&apos;s Solar Detox Facility

Energy Technology Data Exchange (ETDEWEB)

Malato, S.

2002-07-01

Recent decades have witnessed increased contamination of the Earth&apos;s drinking water reserves. To solve this problem, apart from reducing emissions, two main water treatment strategies are being followed: (i) chemical treatment of drinking water, contaminated surface and groundwater and (ii) chemical treatment of waste waters containing biocides or non-biodegradable compounds. The decontamination of drinking water is done mainly by procedures that combine flocculation, filtration, sterilization and conservation, to which a limited number of chemical are added. Normal human sewage water can be efficiently treated in conventional biological processing plants. The chemical treatment of polluted surface and groundwater or wastewater, is part of a long-term strategy to improve the quality of water by eliminating toxic compounds of human origin before returning the water to its natural cycles. This type of treatment is suitable when a biological processing plant cannot be adapted to certain types of pollutants that did not exist when it was designed. (Author) 27 refs.

PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

Energy Technology Data Exchange (ETDEWEB)

Baker, Lindsey A. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States); Allis, C. David [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: alliscd@rockefeller.edu; Wang, Gang G. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: gwang@rockefeller.edu

2008-12-01

Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved &apos;reader/effector&apos; modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized &apos;reader&apos; modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., &apos;writers&apos; and &apos;erasers&apos;) are already known to be involved in various human diseases, mutations in the modification-specific &apos;reader&apos; proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies

Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression

Energy Technology Data Exchange (ETDEWEB)

Song, Kwang-Hoon, E-mail: ksong@kiom.re.kr [Korea Institute of Oriental Medicine, Daejeon 305-811 (Korea, Republic of)

2010-01-29

The orphan nuclear receptor Nur77 (NR4A1) has been reported to play a crucial role in the modulation of diverse metabolic processes in liver. Here, we reported the identification of human apolipoprotein A5 (ApoA5), which implicated in lowering plasma triglyceride levels, as a novel target gene of Nur77. Nur77 induced the human ApoA5 promoter activity. Using 5&apos;-deletion and mutagenesis of human ApoA5 promoter analysis and chromatin immunoprecipitation assays, it was shown that Nur77 directly regulated human ApoA5 gene expression by binding to a Nur77 response element (AAAGGTCA) located in the proximal human ApoA5 promoter region. In addition, we demonstrated that blocking of Nur77 transcriptional activity via overexpression of dominant negative Nur77 suppressed human ApoA5 promoter activity and mRNA expression in human hepatoma cells, HepG2. Taken together, our results demonstrated that Nur77 is a novel regulator of human ApoA5 gene expression and provide a new insight into the role of this orphan nuclear receptor in lipoprotein metabolism and triglyceride homeostasis.

Radio frequency and electromagnetic fields exposure, health risk; Esposizione dell&apos;uomo ai campi elettromagnetici prodotti dai sistemi di telefonia cellulare

Energy Technology Data Exchange (ETDEWEB)

Bernardi, P.; Cavagnaro, P.; Pisa, S.; Piuzzi, E. [Rome Unvi. (Italy). Dipt. di Ingegneria Elettronica

1999-08-01

Health risk for humane exposure at electromagnetic field generate from mobile telephones is very particular. In this work are presented the most important results of research. [Italian] La protezione dell&apos;uomo dall&apos;esposizione di campi elettromagnetici prodotti dai sistemi di telefonia mobile presenta caratteristiche del tutto particolari. Bisogna infatti considerare un duplice apetto: da un lato l&apos;esposizione della popolazione ai campi prodotti dalle antenne trasmittenti delle stazioni radio base e, dall&apos;altro, l&apos;esposizione del singolo utente all&apos;apparato portatile. Insieme all&apos;esame di tali problemi, in questo lavoro vengono presentati i risultati piu&apos; significativi delle ricerche fino ad oggi sviluppate per fornire una base razionale alle normative di protezione e si accenna all&apos;attuale evoluzione della ricerca nel campo.

Excellent solar energy absorbing and retaining fabric material. Chikunetsu hoon sen&apos;i sozai

Energy Technology Data Exchange (ETDEWEB)

Furuta, T. (Unitika Ltd., Osaka (Japan). Central Research Lab.)

1993-11-10

Carbides of group IV transition metals such as ZrC, which are used as solar energy selective absorption film for solar energy collectors, has characteristics of absorbing light with a high energy of 0.6eV or more and of converting it to heat when exposed to light, and of not absorbing but reflecting light with a low energy of less than 0.6eV. By using ZrC as fabric materials, therefore, portable and durable heat absorbing and retaining materials can be produced. The authors have developed a solar energy absorbing and retaining fabric material, &apos;Solar [alpha]&apos; (registered trade mark), which absorbs visible and near infrared rays and converts them to heat, and reflects heat from a human body and confines it. The use of Solar [alpha] has been found in various fields such as clothing as a new material for winter-sportswear, slacks, coats, and swimming suits. In this report, the heat absorbing and retaining mechanisms, basic properties of Solar [alpha], and the results of wearing tests are described. 12 refs., 6 figs., 3 tabs.

How to save the earth planet. Ecology and human spirit. Sauver la planete terre. L&apos;ecologie et l&apos;esprit humain

Energy Technology Data Exchange (ETDEWEB)

Al Gore.

1993-01-01

The author has undertaken for 25 years in all the struggles for the environment protection. His ecology competences are worldwide recognized. With &apos;&apos;HOW TO SAVE THE EARTH PLANET&apos;&apos; AL GORE calls for help facing a great importance economic crisis, the consequences of which are dramatic. Beyond the exhaustive report, very well documented on the scientific topics, he proposes a true ecologic &apos;&apos;Marshall PLAN&apos;&apos; at the planet level, and a global reflection followed by precise and concrete measures. In the beginning of the XXIst century the challenge taken up by AL GORE is also a true defence plea for the future. We are all concerned and our children too. 27 refs.

Day 2 closing lecture: Anthropocene&apos;s archive?

International Nuclear Information System (INIS)

Van Wyck, Peter

2015-01-01

Prof. Peter van Wyck&apos;s lecture drew from Crutzen and Stoermer&apos;s concept of the Anthropocene and argued for its theoretical, practical, and rhetorical value with regard to the broad set of concerns that brought participants to Verdun. As an ontological claim, the Anthropocene offers a conceptual challenge to any meaningful distinction between &apos;human&apos; and &apos;natural&apos; history: the human and natural are globally merged like never before (referring to issues such as global warming, biodiversity, space debris, etc.). The Anthropocene is a new fundamental concept and a philosophical event. It marks, for instance, the time when we ask for consideration of time scales beyond anthropometric dimensions. Within the geological, social, and human sciences, one of the questions of the Anthropocene circles around when it would have started. There are various competing ideas about this. Some date it back to the acquisition of fire, others to the Industrial Revolution, and others to the great acceleration of science and technology in the mid-20. century. Nuclear energy has also been suggested as a signature. Overall, Prof. van Wyck suggested that the Anthropocene, as a kind of cultural memo, offers a moment in which cultural awareness around questions relating to nuclear energy may be broadened and enhanced

Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE-/- mice with or without diabetes

DEFF Research Database (Denmark)

Hanssen, Nordin M J; Brouwers, Olaf; Gijbels, Marion J

2014-01-01

are higher in rupture-prone plaques. We here investigated whether overexpression of human GLO1 in ApoE(-/-) mice could reduce the development of atherosclerosis. METHODS AND RESULTS: We crossed C57BL/6 ApoE(-/-) mice with C57BL/6 GLO1 overexpressing mice (huGLO1(+/-)) to generate ApoE(-/-) (n = 16) and Apo......E(-/-) huGLO1(+/-) (n = 20) mice. To induce diabetes, we injected a subset with streptozotocin (STZ) to generate diabetic ApoE(-/-) (n = 8) and ApoE(-/-) huGLO1(+/-) (n = 13) mice. All mice were fed chow and sacrificed at 25 weeks of age. The GLO1 activity was three-fold increased in huGLO1(+/-) aorta......, but aortic root lesion size and phenotype did not differ between mice with and without huGLO1(+/-) overexpression. We detected no differences in gene expression in aortic arches, in AGE levels and cytokines, in circulating cells, and endothelial function between ApoE(-/-) mice with and without huGLO1...

Substituted Benzamides Containing Azaspiro Rings as Upregulators of Apolipoprotein A-I Transcription

Directory of Open Access Journals (Sweden)

Bin Hong

2012-06-01

Full Text Available Apolipoprotein A-I (Apo A-I is the principal protein component of high density lipoprotein (HDL, which is generally considered as a potential therapeutic target against atherosclerosis. The understanding of the Apo A-I regulation mechanism has fuelled the development of novel HDL targeted therapeutic approaches. To identify novel agents that can upregulate Apo A-I expression, we performed a cell-based reporter assay to screen 25,600 small molecules. Based on the dataset obtained from screening, a series of novel analogs of substituted benzamides containing azaspiro rings were assessed for their ability to induce the transcription of the Apo A-I gene, and the structure-activity relationship (SAR around these analogs was also proposed. The results indicated that the trifluoromethyl substituted benzamide containing an azaspiro ring is a promising backbone for designing Apo A-I transcriptional upregulator and could be viable leads for development of new drugs to prevent and treat atherosclerosis in the future.

Probing the existence of the kaonic nuclear cluster &apos;&apos;ppK{sup -}&apos;&apos; with help of a PWA

Energy Technology Data Exchange (ETDEWEB)

Epple, Eliane [Physik Dept. E12, Technische Universitaet Muenchen, Garching (Germany); Excellence Cluster ' ' Universe' ' , TEM, Garching (Germany); Collaboration: HADES-Collaboration

2015-07-01

The &apos;&apos;ppK{sup -}&apos;&apos; is a well established state in theory and is a candidate for a new kind of hadronic matter formed by antikaons and nucleons. The HADES spectrometer at GSI has probed the existence of such a state by measuring its possible decay products p and Λ. These decay products have been studied specifically in the reaction p+p → p+K{sup +}+Λ at a beam kinetic energy of 3.5 GeV. A partial wave analysis, performed on this final state, helped in describing the event distributions, which is a necessary condition to search for an additional small signal in the statistic. We have found no indication for the production of a kaonic nuclear bound state in our data and have, thus, set an upper limit for its production cross section. Furthermore, did we repeat the analysis of the DISTO collaboration in which a signal like distribution appeared in so-called deviation spectra. We can show that this method is error-prone in terms of the applied selection cuts and is, thus, not reliable in order to make statements about the &apos;&apos;ppK{sup -}&apos;&apos;.

Effects of nocturnal aircraft noise on sleep: results from the &apos;&apos;quiet air traffic&apos;&apos; project; Wirkungen des Nachtfluglaerms auf den Schlaf: Ergebnisse aus dem Projekt &apos;&apos;Leiser Flugverkehr&apos;&apos;

Energy Technology Data Exchange (ETDEWEB)

Samel, A.; Basner, M.; Maass, H.; Mueller, U.; Quehl, J.; Wenzel, J. [Deutsches Zentrum fuer Luft- und Raumfahrt (DLR) in der Helmholtz-Gemeinschaft (HGF), Inst. fuer Luft- und Raumfahrtmedizin, Koeln (Germany)

2005-07-01

In 192 sleep-healthy subjects (18 to 65 y) effects of nocturnal aircraft noise on sleep, stress, performance and subjective factors were investigated in 2240 nights under laboratory and field conditions. In the sleep lab, 112 volunteers were subjected to aircraft noise events by varying numbers and noise levels during 9 nights within a period of 13 nights. 16 further subjects served as control group (i.e. without any noise). 64 subjects were studied in the vicinity of Cologne-Bonn airport during 9 nights. Polysomnographical and acoustical recordings, determination of excretion rates of stress hormones from night urines, performance tests and questionnaires were conducted during all days for the assessment of nocturnal aircraft noise effects. By simultaneous recording of electrophysiological and acoustical data the probability of noise induced awakenings was estimated. Performance and most of psychological parameters did not show significant dose-effect relationships, whereas annoyance did. Epinephrine and norepinephrine did not change under aircraft noise, cortisol did change only in the lab. In the lab, a comparison between all noisy nights and noise-free baseline nights exhibited a non-significant 2-min. reduction of sleep and a 4-min. decrease of slow-wave sleep. In the field, awakenings caused by aircraft noise were detected above a threshold of 33 dB(A) &apos;&apos;at the sleeper&apos;s ear&apos;&apos;. All effects were much less pronounced in the field than in the lab. For the first time, precise dose-effect curves between maximum aircraft noise event levels and electrophysiologically detectable awakenings, and a threshold were empirically established. The results of these studies broadens the knowledge on aircraft noise induced sleep disturbances and immediate consequences for the next day. (orig.)

A model of lipid-free apolipoprotein A-I revealed by iterative molecular dynamics simulation.

Directory of Open Access Journals (Sweden)

Xing Zhang

Full Text Available Apolipoprotein A-I (apo A-I, the major protein component of high-density lipoprotein, has been proven inversely correlated to cardiovascular risk in past decades. The lipid-free state of apo A-I is the initial stage which binds to lipids forming high-density lipoprotein. Molecular models of lipid-free apo A-I have been reported by methods like X-ray crystallography and chemical cross-linking/mass spectrometry (CCL/MS. Through structural analysis we found that those current models had limited consistency with other experimental results, such as those from hydrogen exchange with mass spectrometry. Through molecular dynamics simulations, we also found those models could not reach a stable equilibrium state. Therefore, by integrating various experimental results, we proposed a new structural model for lipid-free apo A-I, which contains a bundled four-helix N-terminal domain (1-192 that forms a variable hydrophobic groove and a mobile short hairpin C-terminal domain (193-243. This model exhibits an equilibrium state through molecular dynamics simulation and is consistent with most of the experimental results known from CCL/MS on lysine pairs, fluorescence resonance energy transfer and hydrogen exchange. This solution-state lipid-free apo A-I model may elucidate the possible conformational transitions of apo A-I binding with lipids in high-density lipoprotein formation.

The best selled car. &apos;'Twizy'&apos; leads the sales statistics of electrically powered vehicles - a test report; Der Meistverkaufte. Renaults &apos;'Twizy'&apos; fuehrt die E-Mobil-Verkaufsstatistik an - ein Fahrbericht

Energy Technology Data Exchange (ETDEWEB)

Welter, Philippe

2013-02-15

Four wheels, two seats, one steering wheel: What does it require more for a small, electrically powered city car? Nothing, says the manufacturer. Two side windows, that is our opinion. With a maximum speed of 80 kilometers per hour and a range of 100 kilometers, the vehicle is certainly ideal for many applications over short distances in the city. PHOTON now uses the &apos;'Twizy'&apos; for almost a year, and gained consistently good experiences.

The influence of chronic stress on anxiety-like behavior and cognitive function in different human GFAP-ApoE transgenic adult male mice.

Science.gov (United States)

Meng, Fan-Tao; Zhao, Jun; Fang, Hui; Liu, Ya-Jing

2015-01-01

The apolipoprotein E (ApoE) ɛ4 allele (ApoE4) is an important genetic risk factor for the pathogenesis of Alzheimer's disease (AD). In addition to genetic factors, environmental factors such as stress may play a critical role in AD pathogenesis. This study was designed to investigate the anxiety-like behavioral and cognitive changes in different human glial fibrillary acidic protein (GFAP)-ApoE transgenic adult male mice under chronic stress conditions. On the open field test, anxiety-like behavior was increased in the non-stressed GFAP-ApoE4 transgenic mice relative to the corresponding GFAP-ApoE3 (ApoE ɛ3 allele) mice. Anxiety-like behavior was increased in the stressed GFAP-ApoE3 mice relative to non-stressed GFAP-ApoE3 mice, but was unexpectedly decreased in the stressed GFAP-ApoE4 mice relative to non-stressed GFAP-ApoE4 mice. On the novel object recognition task, both GFAP-ApoE4 and GFAP-ApoE3 mice exhibited long-term non-spatial memory impairment after chronic stress. Interestingly, short-term non-spatial memory impairment (based on the novel object recognition task) was observed only in the stressed GFAP-ApoE4 male mice relative to non-stressed GFAP-ApoE4 transgenic mice. In addition, short-term spatial memory impairment was observed in the stressed GFAP-ApoE3 transgenic male mice relative to non-stressed GFAP-ApoE3 transgenic male mice; however, short-term spatial memory performance of GFAP-ApoE4 transgenic male mice was not reduced compared to non-stressed control mice based on the Y-maze task. In conclusion, our findings suggested that chronic stress affects anxiety-like behavior and spatial and non-spatial memory in GFAP-ApoE transgenic mice in an ApoE isoform-dependent manner.

Measuring Earth&apos;s Local Magnetic Field Using a Helmholtz Coil

Science.gov (United States)

Williams, Jonathan E.

2014-01-01

In this paper, I present a low-cost interactive experiment for measuring the strength of Earth&apos;s local magnetic field. This activity can be done in most high schools or two-year physics laboratories with limited resources, yet will have a tremendous learning impact. This experiment solidifies the three-dimensional nature of Earth&apos;s…

Calogero&apos;s &apos;goldfish&apos; is indeed a school of free particles

Energy Technology Data Exchange (ETDEWEB)

Nucci, M C [Dipartimento di Matematica e Informatica, Universita di Perugia, 06123 Perugia (Italy)

2004-11-26

A many-body system of N nonlinear ordinary differential equations of second order which is amenable to exact treatments (a &apos;goldfish&apos;) (Calogero 2001 The neatest many-body problem amenable to exact treatments (a &apos;goldfish&apos;?) Physica D 152-153 78-84) is shown to be equivalent through an exact transformation to the equations of one-dimensional motion of (N-1) free particles (a school of free particles, indeed). The transformation is obtained by applying the reduction method and Lie group analysis as introduced in Nucci (1996 The complete Kepler group can be derived by Lie group analysis J. Math. Phys. 37 1772-5)

The Inevitable Universe---Parker-Rhodes&apos; peculiar mixture of ontology and physics

Energy Technology Data Exchange (ETDEWEB)

Noyes, H.P.

1989-12-01

When asked to give a lecture on Parker-Rhodes&apos; physics, I was somewhat non-plused. I almost replied What physics &apos;&apos; --- a point of view that Frederick expresses himself more than once in the book he was working on when he died. But that would be unjust. Whatever his view, I assert that the discovery of the Combinational Hierarchy is one of the most important discoveries&apos;&apos; --- or whatever you want to call it --- in physics made in this century. His calculation of the proton-electron mass ratio is also a fantastic result that we are still trying to come to grips with. And his insight into early cosmology --- what he called a cold big bang&apos;&apos; --- which appeared in an early version of the Theory of Indistinguishables, also had merit. His early universe is a lot closer to my own views now than I realized when I first encountered it. We will mention other insights as I go along. But his views are so different from those of anyone I know or knew, that I have decided to let him speak for himself by reading passages from his manuscript The Inevitable Universe, or TIU, which was still unpublished at the time of his death, and add a few comments on them.

Situated Meaning-Making of the Human Body: A Study of Elementary School Children&apos;s Reasons in Two Different Activities

Science.gov (United States)

Lundin, Mattias; Jakobson, Britt

2014-01-01

In this text we compare children&apos;s expressions in drawings to their statements during interviews, for the purpose of understanding how different situations afford children to make meaning. In specific we study how two different activities interact and afford children to make meaning differently about the human body. The analytic attention is…

&apos;&apos;Die Dependance&apos;&apos; - Logistic center of the fair at Francfort; &apos;&apos;Die Dependance&apos;&apos; - Das Logistikzentrum der Messe Frankfurt

Energy Technology Data Exchange (ETDEWEB)

Klein, W.; Fleischer, J. [Brendel Ingenieure, Frankfurt/Main (Germany); Hummel, D. [FH Zwickau (Germany)

2006-07-01

In early November 2004, the logistic center &apos;&apos;Die Dependance&apos;&apos; was commissioned after a construction time of 21 months. It is the second building (after Hall 3) designed by London&apos;s star architect Nicholas Grimshow for the Frankfurt Fair. The new building will house the fairground managers and the Accente Gastronomie Service GmbH. Accente is a modern caterer for the fairground halls, Its kitchen in the new building is big enough for preparing up to 10,000 meals every day. (orig.)

Radioactive thickness gauge (1962); Jauge d&apos;epaisseur radioactive (1962)

Energy Technology Data Exchange (ETDEWEB)

Guizerix, J. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1962-07-01

The author describes a thickness gauge in which the scintillating crystal detector alternately &apos;sees&apos; a radioactive source through the material which is to be measured and then a control source of the same material; the radiations are separated in time by an absorbing valve whose sections are alternately full and hollow. The currents corresponding to the two sources are separated beyond the photomultiplier tube by a detector synchronized with the rotation of the valve. The quotient of these two currents is then obtained with a standard recording potentiometer. It is found that the average value of the response which is in the form G = f(I{sub 1}/I{sub 2}) is not affected by decay of the radioactive sources, and that it is little influenced by variations of high tension, temperature, or properties of the air in the source detector interval. The performance of the gauge is given. (author) [French] L&apos;auteur decrit une jauge d&apos;epaisseur dans laquelle le cristal scintillant detecteur &apos;voit&apos; alternativement une source radioactive a travers le materiau a mesurer, puis une source de reference de meme nature; la separation des rayonnements est faite dans le temps a l&apos;aide d&apos;un volet absorbeur a secteurs alternativement pleins et creux. Les courants correspondants aux deux sources sont separes apres le tube photomultiplicateur par un detecteur synchrone avec la rotation du volet. On fait ensuite le quotient de ces deux courants a l&apos;aide d&apos;un potientometre enregistreur classique. il resulte de cette disposition que la valeur moyenne de la reponse, qui est de la forme G = f(I{sub 1}/I{sub 2}) n&apos;est pas affectee par la decroissance des sources radioactives, et qu&apos;elle est peu sensible aux variations de haute tension, de temperature ou des proprietes de l&apos;air dans l&apos;intervalle source-detecteur. On donne les performances de cette jauge. (auteur)

Pythagoras&apos;s theorem on a two-dimensional lattice from a &apos;natural&apos; Dirac operator and Connes&apos;s distance formula

Energy Technology Data Exchange (ETDEWEB)

Dai Jian [Theory Group, Department of Physics, Peking University, Beijing (China)]. E-mail: jdai@mail.phy.pku.edu.cn; Song Xingchang [Theory Group, Department of Physics, Peking University, Beijing (China)]. E-mail: songxc@ibm320h.phy.pku.edu.cn

2001-07-13

One of the key ingredients of Connes&apos;s noncommutative geometry is a generalized Dirac operator which induces a metric (Connes&apos;s distance) on the pure state space. We generalize such a Dirac operator devised by Dimakis et al, whose Connes distance recovers the linear distance on an one-dimensional lattice, to the two-dimensional case. This Dirac operator has the local eigenvalue property and induces a Euclidean distance on this two-dimensional lattice, which is referred to as &apos;natural&apos;. This kind of Dirac operator can be easily generalized into any higher-dimensional lattices. (author)

&apos;&apos;Social capitalism&apos;&apos; in renewable energy generation: China and California comparisons

Energy Technology Data Exchange (ETDEWEB)

Clark, Woodrow W. II.; Li, Xing [Clark Strategic Partners, PO Box 17975, Beverly Hills, CA 90210 (United States)

2010-03-15

With a population of over 1.3 billion people, demand for renewable energy is expected to grow to a USD $12 billion market in the near term. Under Renewable Energy Law (REL) in February 2005 in the People&apos;s Republic of China (PRC) passed by the National Congress, renewable energy projects will be able to receive a range of financial incentives starting in 2006, which will more than double the PRC current renewable energy generation from 7% to 15% by 2020. Most of the increase will be in hydroelectric generated power. Nonetheless, the nation and especially the provinces are moving rapidly to develop a wide range of renewable energy generation including solar, wind, geothermal and run of the river. Because China practices &apos;&apos;social capitalism&apos;&apos; as expressed in it&apos;s recurrent Five Year National Plans since 1999, the national government and all the provinces have programs, unlike many western and industrialized nations, to &apos;'plan'&apos; and provide for infrastructures. This paper concerns only the energy infrastructure sector and renewable energy generation in particular. The planning process includes financial incentives and investments which are a major part of the Chinese law focused on &apos;&apos;encouraging foreign investment industries&apos;&apos;. The key part of the law is to guarantee long-term power purchase agreements with state owned and controlled &apos;'utilities'&apos;. In short, China may have gotten the economics of the energy sector correct in its concern for planning and finance. The paper develops these energy infrastructure ideas along with the legal and financial requirements as &apos;'lessons'&apos; learned from the USA and especially California. These lessons now apply to China and allow it to learn from the American mistakes. Empirical data will be drawn from work done in China that examine the renewable energy generation and infrastructures and hence allow the RPC and its

Epidemic juvenile hypothyroidism among a population of Hanford &apos;downwinders&apos;

Energy Technology Data Exchange (ETDEWEB)

Grossman, C.M.; Nussbaum, R.H.; Nussbaum, F.D. [Northwest Radiation Health Alliance, Portland, OR (United States); Kordysh, E.; Goldsmith, J.R. [Dept. of Epidemiology, Ben Gurion Univ. of the Negev, Beer Sheva (Israel)

2001-07-01

Self-defined &apos;downwinders&apos; responded to questionnaires as to their health and their potential exposures to emissions from the Hanford Nuclear Facility in the U.S. The area considered was between the Cascades and the Rocky Mountains, primarily to the East and Northeast of the facility. Of 801 questionnaires, returned, 518 were from women. Of these, 210 reported that they had been diagnosed by their physicians as having hypothyroidism. 31 of the 283 men had reported being diagnosed as hypothyroid. The condition is generally found to be frequent among adult women, but is uncommon in children. 54 of the 210 cases among females were diagnosed among those less than 20 years of age, and 5 out of 31 males were found in this age range. Peak years for diagnosis among females were from 1945 to 1965, with only three juvenile cases occurring after 1970 among 80 female hypothyroid cases overall. Among males there were five juvenile cases in 1955-1960 out of 7 overall, but no juvenile cases among 24 cases at other times. The timing of the onset of this epidemic follows closely after the massive release of I{sup 131} from the facility in 1945, so that a causal relationship is strongly suggested. The counties of residence of cases corresponds to the counties with high cumulative dose estimates in children&apos;s thyroid glands. Validation of the diagnostic criteria was checked in a sample of cases. Other types of thyroid abnormalities were also increased. One case of juvenile thyroid cancer was reported. While thyroid cancer in adults was unusually frequent, the first cases occurred in 1955 and the highest number (8) in 1985. Our findings are consistent with the clinical finding that hypothyroidism in children frequently follows radiation of the head and neck. Similarities with the Marshall Islanders exposed to the nuclear test, &apos;Bravo&apos; and to those exposed near Chernobyl are discussed. (orig.)

Calibration Human Voxel Phantoms for In Vivo Measurement of &apos;&apos;241 Am in Bone at the Whole Body Counter Facility of CIEMAT

Energy Technology Data Exchange (ETDEWEB)

Moraleda, M.; Lopez, M. A.; Gomez Ros, J. M.; Navarro, T.; Navarro, J. F.

2002-07-01

The Whole Body Counting facility of CIEMAT is capable of carrying out In-Vivo measurements of radionuclides emitting X-rays and low energy gamma radiation internally deposited in the body. The system to use for this purpose consists of flour Low energy Germanium (LeGe) Camberra detectors working in the energy range from 10 to 1000 keV. Physical phantoms with a known contamination in the organ of interest are normally used for the calibration of the LEGe detection system. In this document we present a calibration method using the Monte Carlo technique (MCNP4C) over a voxel phantom obtained from a computerized tomography of a real human head. The phantom consists of 104017 (43x59x41) cubic voxels, 4 mn on each side, os specific tissues, but for this simulation only two types are taken into account: adipose tissue and hard bone. The skull is supposed to be contaminated with &apos;&apos;241 Am and the trajectories of the photons are simulated till they reach the germanium detectors. The detectors were also simulated in detail to obtain a good agreement with the reality. In order to verify the accuracy of this procedure to reproduce the experiments, the MCNP results are compared with laboratory measurements of a head phantom simulating an internal contamination of 1000 Bq of &apos;&apos;241 Am deposited in bone. Different relative positions source-detector were tried to look for the best countring geometry for measurement of a contaminated skull. Efficiency values are obtained and compared, resulting in the validation of the mathematical method for the assessment of internal contamination of American deposited in skeleton. (Author) 16 refs.

Differential binding of 125I-IGF-I preparations to human fibroblast monolayers

International Nuclear Information System (INIS)

Conover, C.A.; Misra, P.; Hintz, R.L.; Rosenfeld, R.G.

1988-01-01

Specific, high affinity binding of 125 I-IGF-I to the type IIGF receptor on human fibroblast monolyaers was not altered by varying feeding schedules, serum lots, washing procedures, or incubation times and temperatures. However, markedly different competitive binding curves were obtained when different iodinated IGF-I preparations were used. Five of six radioligands bound preferentially to the type IIGF receptor on human fibroblast monolayers, with 50% displacement at 4-8 μg/l unlabelled IGF-I; with one radioligand a paradoxical 20-200% increase in 125 I-IGF-I binding was observed at low concentrations of unlabelled IGF-I, while concentrations as high as 100 μg/l IGF-I failed to displace this radioligand. The latter binding pattern cannot be accounted for by 125 -I-IGF-I binding to the type II IGF receptor. These data indicate that various radioligands may have preferential affinities for different IGF-I binding sites on human fibroblast monolayers. (author)

Preparation of data relevant to &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and Equivalent Initial Enrichment&apos;&apos; for burnup credit evaluation

Energy Technology Data Exchange (ETDEWEB)

Nomura, Yasushi; Okuno, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Murazaki, Minoru [Tokyo Nuclear Service Inc., Tokyo (Japan)

2001-11-01

Based on the PWR spent fuel composition data measured at JAERI, two kinds of simplified methods such as &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and &apos;&apos;Equivalent Initial Enrichment&apos;&apos; have been introduced. And relevant evaluation curves have been prepared for criticality safety evaluation of spent fuel storage pool and transport casks, taking burnup of spent fuel into consideration. These simplified methods can be used to obtain an effective neutron multiplication factor for a spent fuel storage/transportation system by using the ORIGEN2.1 burnup code and the KENO-Va criticality code without considering axial burnup profile in spent fuel and other various factors introducing calculated errors. &apos;&apos;Equivalent Uniform Burnup&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis, in which the experimentally obtained isotopic composition together with a typical axial burnup profile and various factors such as irradiation history are considered on the conservative side. On the other hand, Equivalent Initial Enrichment&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis such as above when it is used in the so called fresh fuel assumption. (author)

A neural model for transient identification in dynamic processes with &apos;don&apos;t know&apos; response

Energy Technology Data Exchange (ETDEWEB)

Mol, Antonio C. de A. E-mail: mol@ien.gov.br; Martinez, Aquilino S. E-mail: aquilino@lmp.ufrj.br; Schirru, Roberto E-mail: schirru@lmp.ufrj.br

2003-09-01

This work presents an approach for neural network based transient identification which allows either dynamic identification or a &apos;don&apos;t know&apos; response. The approach uses two &apos;jump&apos; multilayer neural networks (NN) trained with the backpropagation algorithm. The &apos;jump&apos; network is used because it is useful to dealing with very complex patterns, which is the case of the space of the state variables during some abnormal events. The first one is responsible for the dynamic identification. This NN uses, as input, a short set (in a moving time window) of recent measurements of each variable avoiding the necessity of using starting events. The other one is used to validate the instantaneous identification (from the first net) through the validation of each variable. This net is responsible for allowing the system to provide a &apos;don&apos;t know&apos; response. In order to validate the method, a Nuclear Power Plant (NPP) transient identification problem comprising 15 postulated accidents, simulated for a pressurized water reactor (PWR), was proposed in the validation process it has been considered noisy data in order to evaluate the method robustness. Obtained results reveal the ability of the method in dealing with both dynamic identification of transients and correct &apos;don&apos;t know&apos; response. Another important point studied in this work is that the system has shown to be independent of a trigger signal which indicates the beginning of the transient, thus making it robust in relation to this limitation.

Switzerland as Europe&apos;s &apos;'battery'&apos;. Wishful dream or reality?; Die Schweiz als &apos;&apos;Batterie Europas&apos;&apos;. Utopie oder Realitaet?

Energy Technology Data Exchange (ETDEWEB)

Kammer, Adrian; Zurmuehle, Damian; Salzmann, Michael; Baumgartner, Raphael; Mignone, Domenico [Bernische Kraftwerke (BKW), Bern (Switzerland). Energiewirtschaftliche Planung und Prognose

2015-04-15

There are plans for Swiss pumped hydrostorage systems to absorb large quantities of excess electricity from European wind and solar power generation. Model-based analyses have shown however that &apos;'Europe&apos;s battery&apos;&apos;, as Switzerland would like to see itself, will not be needed until the middle of this century. Even if all extension projects currently in progress should be completed, Switzerland will not have sufficient pump capacity or import capacity to absorb large amounts of excess electricity. Furthermore, the primary means of making storage capacity available for import electricity would be to reduce reservoir power plant capacity. In view of all this Switzerland&apos;s hopes for a role as a major European electricity storage provider appear somewhat exaggerated even in the long-term perspective.

&apos;&apos;Measuring the Costs of Climate Change Policies&apos;&apos;

Energy Technology Data Exchange (ETDEWEB)

Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P.M.

2003-05-09

Studies of the costs of climate change policies have utilized a variety of measures or metrics for summarizing costs. The leading economic models have utilized GNP, GDP, the &apos;&apos;area under a marginal cost curve,&apos;&apos; the discounted present value of consumption, and a welfare measure taken directly from the utility function of the model&apos;s representative agent (the &apos;&apos;Equivalent Variation&apos;&apos;). Even when calculated using a single model, these metrics do not necessarily give similar magnitudes of costs or even rank policies consistently. This paper discusses in non-technical terms the economic concepts lying behind each concept, the theoretical basis for expecting each measure to provide a consistent ranking of policies, and the reasons why different measures provide different rankings. It identifies a method of calculating the &apos;&apos;Equivalent Variation&apos;&apos; as theoretically superior to the other cost metrics in ranking policies. When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank

S.A.C.I.: Incident Combat Support System; S.A.C.I.: Sistema de Apoio ao Combate de Incidentes

Energy Technology Data Exchange (ETDEWEB)

Macedo, Antonio R.L. [ARMTEC Tecnologia em Robotica, Fotrtaleza, CE (Brazil); Macedo, Antonio R.M. [Universidade de Fortaleza, CE (Brazil)

2004-07-01

The incidents that occur in the petrochemical industry are extremely dangerous, because of the range of temperature that it reaches and the radius of the explosion. For this reason the S.A.C.I. that is an Incident&apos;s Combat Support System was developed. The purpose of this paper is to present the complete operational capability of this machine, and also some of the construction design calculations. It is a controlled-by-distance robot that carries one water cannon that generates fog, stream or foam with a limit pressure of 125 psi. It works within 90 m from the operator, has 3 degrees of freedom and a minimum autonomy of 3 hours. Before this prototype was made, only the United Kingdom by Qinetiq and the Japan by the Tokyo Fire Department had this technology. This prototype is around 70% of the investment of the ones in the market. The tests shown in the paper were made in the training bunker of Ceara&apos;s Military Fire Corp. Headquarters and in an arena in the Gloria Marine in Rio de Janeiro. The results of this project is a national product that improves the incident&apos;s combat response time, saving the most important resource, that is the human been. (author)

Moving from the CDM to &apos;various approaches&apos;

International Nuclear Information System (INIS)

Shishlov, Igor; Bellassen, Valentin

2014-03-01

The Clean Development Mechanism (CDM) facilitated the emergence and deployment of low-cost greenhouse gas (GHG) abatement technologies such as destruction of industrial gases and capturing methane from landfills and coal mines. Some of these technologies are now ripe to &apos;graduate&apos; from the CDM into other, more mainstream, economic tools. The first such step was taken in September 2013 when the G20 leaders agreed to phase out HFCs - highly potent greenhouse gases - including HFC-23 that was the focus of 19 CDM projects. A potential HFC-23 abatement fund under the Montreal Protocol could reduce up to 1.8 Gt CO 2 e by 2020 at a cost of under US$0.2 per ton of CO 2 e, i.e. much cheaper than the price paid to CDM projects through carbon crediting. The next potential candidate technology to &apos;graduate&apos; from the CDM is the abatement of nitrous oxide (N 2 O) emissions in the chemical industry, which have already been placed on the agenda of the Montreal Protocol. (authors)

Pumped storage project &apos;&apos;Energiespeicher Riedl&apos;&apos;; Das Projekt Energiespeicher Riedl

Energy Technology Data Exchange (ETDEWEB)

Mayr, Dominik [Verbund Hydro Power AG, Vienna (Austria); Schmauss, Juergen [Regierung von Niederbayern, Landshut (Germany); Neuwerth, Sabine [Grenzkraftwerke GmbH, Simbach am Inn (Germany)

2012-07-01

The &apos;&apos;Donaukraftwerk Jochenstein AG&apos;&apos; (DKJ) plans at the river power plant Jochenstein on the Danube in the district of Passau, Bavaria, South-east Germany, the construction of a modern pumped-storage hydropower plant with a capacity of 300 megawatts, the pumped storage &apos;&apos;Energiespeicher Riedl&apos;&apos;. The planned plant is a regionally significant project by the Regional Planning act. Therefore, the DKJ as applicant submitted the documents for the regional planning proceedings to the Government of Lower Bavaria, which completed the process with the positive regional planning assessment under provisos on 01.08.2011, which led to an optimization of the project layout. (orig.)

Three ways to storage solution. &apos;&apos;Lead or Lithium?&apos;&apos;. This is not the only basic issue in a storage system; Drei Wege zur Speicherloesung. &apos;&apos;Blei oder Lithium?&apos;&apos; Dies ist nicht die einzige Grundsatzfrage bei einem Speichersystem

Energy Technology Data Exchange (ETDEWEB)

Welter, Philippe; Siemer, Jochen

2013-06-15

The number of solar power storage systems offered is now in the hundreds, if one includes all possible product combinations. We show in the following pages a selection of examples of typical solutions, which are by the KfW program &apos;&apos;Renewable Energy - Storage&apos;&apos; eligible&apos;&apos;. With various modifications, they can be divided into three groups: battery inverter with built-in storage, external storage on the DC side of the PV system and stand-alone systems on AC power. [German] Die Zahl der angebotenen Solarstromspeichersysteme geht mittlerweile in die Hunderte, wenn man alle moeglichen Produktkombinationen einbezieht. Wir zeigen auf den folgenden Seiten eine exemplarische Auswahl an typischen Loesungen, die mittels KfW-Programm &apos;&apos;Erneuerbare Energien - Speicher&apos;&apos; foerderfaehig sind. Mit diversen Modifikationen lassen sie sich in drei Gruppen einteilen: Akkuwechselrichter mit integriertem Speicher, externe Speicher an der Gleichstromseite der Photovoltaikanlage und Stand-alone-Systeme am Wechselstromnetz.

Apolipoproteins A-I, B, and C-III and Obesity in Young Adult Cherokee

Directory of Open Access Journals (Sweden)

Wenyu Wang

2017-01-01

Full Text Available Since young adult Cherokee are at increased risk for both diabetes and cardiovascular disease, we assessed association of apolipoproteins (A-I, B, and C-III in non-HDL and HDL with obesity and related risk factors. Obese participants (BMI ≥ 30 aged 20–40 years (n=476 were studied. Metabolically healthy obese (MHO individuals were defined as not having any of four components of the ATP-III metabolic syndrome after exclusion of waist circumference, and obese participants not being MHO were defined as metabolically abnormal obese (MAO. Associations were evaluated by correlation and regression modeling. Obesity measures, blood pressure, insulin resistance, lipids, and apolipoproteins were significantly different between groups except for total cholesterol, LDL-C, and HDL-apoC-III. Apolipoproteins were not correlated with obesity measures with the exception of apoA-I with waist and the waist : height ratio. In a logistic regression model apoA-I and the apoB : apoA-I ratio were significantly selected for identifying those being MHO, and the result (C-statistic = 0.902 indicated that apoA-I and the apoB : apoA-I ratio can be used to identify a subgroup of obese individuals with a significantly less atherogenic lipid and apolipoprotein profile, particularly in obese Cherokee men in whom MHO is more likely.

A BanI RFLP at a deletion hotspot in the human dystrophin gene

Energy Technology Data Exchange (ETDEWEB)

Read, A.P.; Mountford, R. (St. Mary' s Hospital, Manchester (England))

1990-01-25

Cf56a is a 0.9 kb EcoRI fragment of dystrophin cDNA in pUC13. Cf56a is identical to Kunkel&apos;s cDNA probe 8. Constant bands of 14.4, 11.0, 8.1, 6.2 and 1.3 kb correspond to exons I, N, L, N and K respectively. The polymorphic band is exon J (exon 48, 1.2+3.9 kb HindIII bands). This exon is deleted in 25% of all Duchenne/Becker dystrophy boys. Therefore this RFLP is useful for determining carrier status of at-risk females by showing heterozygosity or apparent non-maternity.

Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression

International Nuclear Information System (INIS)

Song, Kwang-Hoon

2010-01-01

The orphan nuclear receptor Nur77 (NR4A1) has been reported to play a crucial role in the modulation of diverse metabolic processes in liver. Here, we reported the identification of human apolipoprotein A5 (ApoA5), which implicated in lowering plasma triglyceride levels, as a novel target gene of Nur77. Nur77 induced the human ApoA5 promoter activity. Using 5'-deletion and mutagenesis of human ApoA5 promoter analysis and chromatin immunoprecipitation assays, it was shown that Nur77 directly regulated human ApoA5 gene expression by binding to a Nur77 response element (AAAGGTCA) located in the proximal human ApoA5 promoter region. In addition, we demonstrated that blocking of Nur77 transcriptional activity via overexpression of dominant negative Nur77 suppressed human ApoA5 promoter activity and mRNA expression in human hepatoma cells, HepG2. Taken together, our results demonstrated that Nur77 is a novel regulator of human ApoA5 gene expression and provide a new insight into the role of this orphan nuclear receptor in lipoprotein metabolism and triglyceride homeostasis.

Beyond low-level activity: On a &apos;non-radioactive&apos; gas mantle

Energy Technology Data Exchange (ETDEWEB)

Poljanc, Karin [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria); Steinhauser, Georg [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria)]. E-mail: georg.steinhauser@ati.ac.at; Sterba, Johannes H. [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria); Buchtela, Karl [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria); Bichler, Max [Atominstitut der Osterreichischen Universitaeten, Vienna University of Technology, Stadionallee 2, 1020 Vienna (Austria)

2007-03-01

Gas mantles for camping gas lanterns sometimes contain thorium compounds. During the last years, the use of thorium-free gas mantles has become more and more popular due to the avoidance of a radioactive heavy metal. We investigated a gas mantle type that is declared to be &apos;non-radioactive&apos; and that can be bought in Austria at the moment. Methods used were Instrumental Neutron Activation Analysis (INAA), {gamma}-spectroscopy, and Liquid Scintillation Counting (LSC). We found massive thorium contents of up to 259 mg per gas mantle. Leaching experiments showed that only 0.4% of the Th but approximately 90% of the decay products of {sup 232}Th can be leached under conditions simulating sucking and chewing with human saliva. In this paper, the investigation of these gas mantles including the consideration of the environmental hazard caused by disposed mantles and the health hazard for unsuspecting consumers is presented and legal consequences are discussed for this fraud.

Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.

Directory of Open Access Journals (Sweden)

Soazig Le Lay

Full Text Available Caveolin-1 (Cav1, a structural protein required for the formation of invaginated membrane domains known as caveolae, has been implicated in cholesterol trafficking and homeostasis. Here we investigated the contribution of Cav1 to apolipoprotein A-I (apoA-I cell surface binding and intracellular processing using mouse embryonic fibroblasts (MEFs derived from wild type (WT or Cav1-deficient (Cav1(-/- animals. We found that cells expressing Cav1 have 2.6-fold more apoA-I binding sites than Cav1(-/- cells although these additional binding sites are not associated with detergent-free lipid rafts. Further, Cav1-mediated binding targets apoA-I for internalization and degradation and these processes are not correlated to cholesterol efflux. Despite lower apoA-I binding, cholesterol efflux from Cav1(-/- MEFs is 1.7-fold higher than from WT MEFs. Stimulation of ABCA1 expression with an LXR agonist enhances cholesterol efflux from both WT and Cav1(-/- cells without increasing apoA-I surface binding or affecting apoA-I processing. Our results indicate that there are at least two independent lipid binding sites for apoA-I; Cav1-mediated apoA-I surface binding and uptake is not linked to cholesterol efflux, indicating that membrane domains other than caveolae regulate ABCA1-mediated cholesterol efflux.

Results of Clinical Tests of Phytopreparation &apos;&apos;Tkis Nobati&apos;&apos;

International Nuclear Information System (INIS)

Khositashvili, V.; Khositashvili, L.; Atuashvili, N.; Osmanova, V.; Chankseliani, Z.

2005-01-01

The present paper deals with the results of the study of natural vegetative extract of Folium pini. On the basis of multiple experiments it has been established that phytopreparation &apos;&apos;Tkis Nobati&apos;&apos; strengthens the leucocytoprotection of organism and improves physiological state in oncologic patients in the process of chemoradiotherapy treatment. The preparation &apos;&apos;Tkis Nobati&apos;&apos; provides the elimination of heavy metals from the organism. (author)

ApoE polymorphisms in narcolepsy

Science.gov (United States)

Gencik, Martin; Dahmen, Norbert; Wieczorek, Stefan; Kasten, Meike; Gencikova, Alexandra; Epplen, Jorg T

2001-01-01

Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset neuronal degeneration in Alzheimer disease and other neurodegenerative diseases as well. Methods To clarify whether the ApoE4 phenotype predisposes to narcolepsy or associates with an earlier disease onset, we have genotyped the ApoE gene in 103 patients with narcolepsy and 101 healthy controls. Results The frequency of the E4 allele of the ApoE gene was 11% in the patient and 15% in the control groups. Furthermore, the mean age of onset did not differ between the ApoE4+ and ApoE4- patient groups. Conclusion Our results exclude the ApoE4 allele as a major risk factor for narcolepsy. PMID:11560764

ApoE polymorphisms in narcolepsy

Directory of Open Access Journals (Sweden)

Kasten Meike

2001-08-01

Full Text Available Summary Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset neuronal degeneration in Alzheimer disease and other neurodegenerative diseases as well. Methods To clarify whether the ApoE4 phenotype predisposes to narcolepsy or associates with an earlier disease onset, we have genotyped the ApoE gene in 103 patients with narcolepsy and 101 healthy controls. Results The frequency of the E4 allele of the ApoE gene was 11% in the patient and 15% in the control groups. Furthermore, the mean age of onset did not differ between the ApoE4+ and ApoE4- patient groups. Conclusion Our results exclude the ApoE4 allele as a major risk factor for narcolepsy.

SMM J04135+10277: A CANDIDATE EARLY-STAGE &apos;'WET-DRY'&apos; MERGER OF TWO MASSIVE GALAXIES AT z = 2.8

Energy Technology Data Exchange (ETDEWEB)

Riechers, Dominik A., E-mail: dr@astro.cornell.edu [Astronomy Department, California Institute of Technology, MC 249-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States)

2013-03-10

We report interferometric imaging of CO(J = 3{yields}2) emission toward the z = 2.846 submillimeter-selected galaxy SMM J04135+10277, using the Combined Array for Research in Millimeter-wave Astronomy (CARMA). SMM J04135+10277 was previously thought to be a gas-rich, submillimeter-selected quasar, with the highest molecular gas mass among high-z quasars reported in the literature. Our maps at {approx}6 Multiplication-Sign improved linear resolution relative to earlier observations spatially resolve the emission on {approx}1.&apos;&apos;7 scales, corresponding to a (lensing-corrected) source radius of {approx}5.2 kpc. They also reveal that the molecular gas reservoir, and thus, likely the submillimeter emission, is not associated with the host galaxy of the quasar, but with an optically faint gas-rich galaxy at 5.&apos;&apos;2, or 41.5 kpc projected distance from the active galactic nucleus (AGN). The obscured gas-rich galaxy has a dynamical mass of M{sub dyn} sin{sup 2} i = 5.6 Multiplication-Sign 10{sup 11} M{sub Sun }, corresponding to a gas mass fraction of {approx_equal}21%. Assuming a typical M{sub BH}/M{sub *} ratio for z {approx}> 2 quasars, the two galaxies in this system have an approximate mass ratio of {approx}1.9. Our findings suggest that this quasar-starburst galaxy pair could represent an early stage of a rare major, gas-rich/gas-poor ({sup w}et-dry{sup )} merger of two massive galaxies at z = 2.8, rather than a single, gas-rich AGN host galaxy. Such systems could play an important role in the early buildup of present-day massive galaxies through a submillimeter-luminous starburst phase, and may remain hidden in larger numbers among rest-frame far-infrared-selected quasar samples at low and high redshift.

Monoclonal antibodies directed to human insulin-like growth factor I (IGF I)

International Nuclear Information System (INIS)

Laubli, U.K.; Baier, W.; Celio, M.R.; Binz, H.; Humbel, R.E.

1982-01-01

Mouse hybridomas secreting antibodies to human insulin-like growth factor I (IGF I) were produced by fusion of spleen cells of hyperimmunised mice with FO mouse-myeloma cells. Eight clones producing antibodies against human IGF I have been isolated, two of which have been characterised. One was used in a radioimmunoassay, the other for immunopurification of IGF. (Auth.)

Children&apos;s exposure to indoor air in urban nurseries-part I: CO{sub 2} and comfort assessment

Energy Technology Data Exchange (ETDEWEB)

Branco, P.T.B.S.; Alvim-Ferraz, M.C.M.; Martins, F.G.; Sousa, S.I.V., E-mail: sofia.sousa@fe.up.pt

2015-07-15

Indoor air quality (IAQ) in nurseries is an emerging case-study. Thus, this study, as the Part I of the larger study “Children&apos;s exposure to indoor air in urban nurseries”, aimed to: i) evaluate nurseries’ indoor concentrations of carbon dioxide (CO{sub 2}), a global IAQ indicator, in class and lunch rooms; ii) assess indoor comfort parameters–temperature (T) and relative humidity (RH); and iii) analyse them according to guidelines and references for IAQ, comfort and children&apos;s health. Indoor continuous measurements were performed. Non-compliances with guidelines were found in comfort parameters, which could cause discomfort situations and also microbial proliferation. Exceedances in CO{sub 2} concentrations were also found and they were caused by poor ventilation and high classroom occupation. More efficient ventilation and control of comfort parameters, as well as to reduce occupation by reviewing Portuguese legislation on that matter, would certainly improve IAQ and comfort in nurseries and consequently safeguard children&apos;s health. - Highlights: • High occupation and poor ventilation were main determinants of IAQ in nurseries. • T and RH indoor values found in nurseries are likely to cause thermal discomfort. • Building characteristics and an inadequate ventilation determined T and RH values. • High CO{sub 2} concentrations found could indicate accumulation of other air pollutants.

Blunt traumatic rupture of a mainstem bronchus: spiral CT demonstration of the &apos;&apos;fallen lung&apos;&apos; sign

Energy Technology Data Exchange (ETDEWEB)

Wintermark, M.; Schnyder, P.; Wicky, S. [Dept. of Diagnostic and Interventional Radiology, University Hospital, Lausanne (Switzerland)

2001-03-01

Tracheo-bronchial injuries occur in less than 1 % of blunt chest trauma patients. Indirect signs, such as pneumomediastinum, pneumothorax, and/or subcutaneous emphysema, are revealed on admission plain films and chest CT survey. In most instances, however, tracheo-bronchoscopy is mandatory in assessing the definite diagnosis of tracheo-bronchial lesion. Occasionally, an abnormal course of a mainstem bronchus or a &apos;&apos;fallen lung&apos;&apos; sign, featuring a collapsed lung in a dependent position, hanging on the hilum only by its vascular attachments, may allow for CT diagnosis of a blunt traumatic bronchial injury. (orig.)

A model-independent &apos;&apos;general search&apos;&apos; for new physics with the ATLAS detector at LHC

Energy Technology Data Exchange (ETDEWEB)

Bianchi, Riccardo Maria

2014-03-18

The LHC particle collider accelerates bunches of protons at energies never reached before, thus opening a completely new landscape of new physics. In this scenario the number of possible physics processes and signatures becomes virtually infinite, making the setup of dedicated analyses impossible. Moreover there are regions of the phase-space where signals of new physics are not very likely to be found, or where suitable theoretical models are missing, and it is important to be able to reveal new processes from such regions as well. At the time this Thesis was started, no model-independent analysis had been set for the ATLAS experiment at LHC. The goal of this work was then to conceive and develop a new model-independent &apos;&apos;General Search&apos;&apos; for ATLAS, and to explore its possibilities. The new analysis has been then implemented and run over the first data which have been collected by the ATLAS experiment at a centre-of-mass energy of 7 TeV. This work presents the motivation of the data analysis, describes its implementation and shows the results. The data have shown a very good agreement with the Standard Model expectation and no evidence of new physics has been observed. Nevertheless, an efficient strategy and methodology for a new model-independent &apos;&apos;General Search&apos;&apos; have been defined and they are ready to be used in a next version of this analysis, over a larger set of experimental data. During this work, a new innovative software framework has been also conceived and developed to ease the implementation of physics analysis code using Computer-Aided- Software-Engineering (CASE) principles. The framework has been successfully used to analyze the very first LHC data, and then it has been transformed into an open-source modular framework for HEP data analysis, and presented at Physics and Computer Science international conferences.

Graves&apos; ophthalmopathy and {sup 1}31{sup I} therapy

Energy Technology Data Exchange (ETDEWEB)

Marcocci, C.; Bartalena, L.; Tanda, M.L.; Manetti, L.; Dell' Unto, E.; Mazzi, B.; Rocchi, R.; Barbesino, G.; Pinchera, A. [Pisa Univ. of Pisa, Pisa (Italy). Dept. of Endocrinology and Metabolism

1999-12-01

Graves&apos; ophthalmopathy is an autoimmune process initiated and maintained by antigen(s) shared by the thyroid and the orbit. A matter of argument concerns the choice of the method of treatment for Graves&apos; hyperthyroidism when clinically evident ophthalmopathy is present. Restoration of euthyroidism appears to be beneficial for ophthalmopathy. On the other hand the continuing disease activity associated with the recurrence of hyperthyroidism appears to adversely affect the course of ophthalmopathy. For these reasons it is our opinion that in patients with Graves&apos; hyperthyroidism and ophthalmopathy the permanent control of thyroid hyper function by ablation of thyroid tissue should be obtained by radioiodine therapy or thyroidectomy. The rationale for an ablative strategy is the following: (i) permanent control of hyperthyroidism avoids exacerbations of eye disease associated with recurrence of hyperthyroidism; (ii) hypothyroidism, which follows thyroid tissue ablation, should be regarded as a therapeutic end point rather than as an undesirable result; (iii) ablation of thyroid tissue may result in the removal of both the thyroid-orbit cross-reacting antigen(s) and the major source of thyroid-auto reactive lymphocytes. The relationship between radioiodine therapy and the course of GO is a matter of controversy, and some authors have suggested that radioiodine administration ma be associated with a worsening of preexisting ophthalmopathy. This was not observed when radioiodine treatment was associated with a 3-month oral course of prednisone. The development or progression of GO after radioiodine therapy might be due to the release of thyroid antigens following radiation injury and to subsequent exacerbations of autoimmune reactions directed towards antigens shared by the thyroid and the orbit. The view that radioiodine therapy may be associated with a progression of ophthalmopathy is not shared by some authors who claim that the apparent link between

&apos;&apos;Wie alles sich zum Ganzen webt&apos;&apos;: on a new orientation for the concept of matter, based on relations between quantum physics and cosmology

Energy Technology Data Exchange (ETDEWEB)

Goernitz, T. [Inst. fuer Didaktik der Physik, J.W.Goethe-Univ., Frankfurt/Main (Germany)

2007-07-01

It is common sense between physicists that in the beginning the cosmos is in a narrow relationship to quantum phenomena. Because of the universal validity of quantum theory this relation remains significant in the whole cosmic evolution. Whereas a classical approach is sufficient for the description of many phenomena it is no more useful at last for the case of the ground state of a system. This holds also for the cosmos. The black holes are that part of physics where quantum theory and gravitational theory come into close contact. There a Gedankenexperiment becomes possible that clarifies the fundamental role of abstract quantum information. We give it a new name (Protyposis) because it must be imagined without emitter, receiver and moreover without any concrete meaning. This meaning-free abstract quantum information is defined by means of black holes and cosmology. Protyposis enables a new conception for &apos;'matter'&apos; and makes possible to overcome the problems of the &apos;'Lego-world-view'&apos;, which result from the attempt to find the &apos;&apos;simple and therefore basic concepts&apos;&apos; in the range of spatial smallness. Matter can be understood now as &apos;&apos;formed and condensed quantum information&apos;&apos;. But on a first view it is nothing to see from its character of being information, as like matter does not appear as &apos;&apos;pure motion&apos;&apos;, what it is also because of E=mc{sup 2}. (orig.)

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.

Science.gov (United States)

Lane-Donovan, Courtney; Herz, Joachim

2017-06-01

The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role this receptor family plays in the CNS. Surprisingly, it was discovered that two LDLR family members, ApoE receptor 2 (Apoer2) and VLDL receptor (Vldlr), play key roles in brain development and adult synaptic plasticity, primarily by mediating Reelin signaling. This review focuses on Apoer2 and Vldlr signaling in the CNS and its role in human disease. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

Molecular imaging of inflammation in the ApoE -/- mouse model of atherosclerosis with IodoDPA

International Nuclear Information System (INIS)

Foss, Catherine A.; Bedja, Djahida; Mease, Ronnie C.; Wang, Haofan; Kass, David A.; Chatterjee, Subroto; Pomper, Martin G.

2015-01-01

Background: Atherosclerosis is a common and serious vascular disease predisposing individuals to myocardial infarction and stroke. Intravascular plaques, the pathologic lesions of atherosclerosis, are largely composed of cholesterol-laden luminal macrophage-rich infiltrates within a fibrous cap. The ability to detect those macrophages non-invasively within the aorta, carotid artery and other vessels would allow physicians to determine plaque burden, aiding management of patients with atherosclerosis. Methods and results: We previously developed a low-molecular-weight imaging agent, [ 125 I]iodo-DPA-713 (iodoDPA), which selectively targets macrophages. Here we use it to detect both intravascular macrophages and macrophage infiltrates within the myocardium in the ApoE -/- mouse model of atherosclerosis using single photon emission computed tomography (SPECT). SPECT data were confirmed by echocardiography, near-infrared fluorescence imaging and histology. SPECT images showed focal uptake of radiotracer at the aortic root in all ApoE -/- mice, while the age-matched controls were nearly devoid of radiotracer uptake. Focal radiotracer uptake along the descending aorta and within the myocardium was also observed in affected animals. Conclusions: IodoDPA is a promising new imaging agent for atherosclerosis, with specificity for the macrophage component of the lesions involved. - Highlights: • [ 125 I]iodoDPA SPECT detects atherosclerotic plaques in ApoE -/- mice with high contrast. • Plaques are detected in ApoE -/- mice regardless of diet with iodoDPA. • iodoDPA has very low uptake in healthy tissue including healthy TSPO + tissues at 24 h

Financial and tax risks at implementation of &apos;&apos;Chayanda- Lensk&apos;&apos; section of &apos;&apos;Sila Sibiri&apos;&apos; gas transportation system construction project

International Nuclear Information System (INIS)

Sharf, I V; Chukhareva, N V; Kuznetsova, L P

2014-01-01

High social and economic importance of large-scale projects on gasification of East Siberian regions of Russia and diversifying gas exports poses the problem of complex risk analysis of the project. This article discusses the various types of risks that could significantly affect the timing of the implementation and effectiveness of the project for the construction of the first line of &apos;&apos;Sila Sibiri&apos;&apos;, the &apos;'Chayanda-Lensk'&apos; section. Special attention is paid to financial and tax aspects of the project. Graphically presented analysis of the dynamics of financial indicators reflect certain periods of effectiveness in implementing the project. Authors also discuss the possible causes and consequences of risks

Detection of a new &apos;nematic-like&apos; phase in liquid crystal-amphiphile mixture by differential scanning calorimetry

Energy Technology Data Exchange (ETDEWEB)

Dan, Kaustabh, E-mail: kaustabhdan@gmail.com; Roy, Madhusudan, E-mail: kaustabhdan@gmail.com; Datta, Alokmay, E-mail: kaustabhdan@gmail.com [Surface Physics and Materials Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar Block, Sector 1, Kolkata-700064 (India)

2014-04-24

Differential Scanning Calorimetry (DSC) studies on phase transitions of the pure liquid crystalline material N-4-methoxybenzylidene-4-butylaniline (MBBA) and mixtures of MBBA and the amphiphile Stearic Acid (StA) show significant changes in the behavior of mixture from pure MBBA, as regards the nematic-isotropic (N-I) transition temperature (T{sub c}) and other thermodynamic parameters like enthalpy, specific heat and activation energy with concentration of StA. In particular, the convexity of the Arrhenius plot in pure MBBA vanishes with StA concentration pointing to the formation of a new, perhaps &apos;nematic-like&apos;, phase in the mixtures.

Simulating human behavior for national security human interactions.

Energy Technology Data Exchange (ETDEWEB)

Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

2007-01-01

This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the &apos;&apos;Simulating Human Behavior for National Security Human Interactions&apos;&apos; project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

MID-INFRARED HIGH-CONTRAST IMAGING OF HD 114174 B: AN APPARENT AGE DISCREPANCY IN A &apos;'SIRIUS-LIKE'&apos; BINARY SYSTEM

Energy Technology Data Exchange (ETDEWEB)

Matthews, Christopher T.; Crepp, Justin R. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Skemer, Andrew; Hinz, Philip M.; Bailey, Vanessa P.; Defrere, Denis; Leisenring, Jarron [Department of Astronomy, University of Arizona, 993 N. Cherry Ave, Tucson, AZ 85721 (United States); Gianninas, Alexandros; Kilic, Mukremin [Department of Physics and Astronomy, University of Oklahoma, Norman, OK 73019 (United States); Skrutskie, Michael [Department of Astronomy, University of Virginia, Charlottesville, VA 22904 (United States); Esposito, Simone; Puglisi, Alfio [Istituto Nazionale di Astrofisica, Osservatorio Astrofisico di Arcetri Largo E. Fermi I-550125 Firenze (Italy)

2014-03-10

We present new observations of the faint &apos;'Sirius-like'&apos; companion discovered to orbit HD 114174. Previous attempts to image HD 114174 B at mid-infrared wavelengths using NIRC2 at Keck have resulted in a non-detection. Our new L&apos;-band observations taken with the Large Binocular Telescope and L/M-band InfraRed Camera recover the companion (ΔL = 10.15 ± 0.15 mag, ρ = 0.&apos;&apos;675 ± 0.&apos;&apos;016) with a high signal-to-noise ratio (10σ). This measurement represents the deepest L&apos; high-contrast imaging detection at subarcsecond separations to date, including extrasolar planets. We confirm that HD 114174 B has near-infrared colors consistent with the interpretation of a cool white dwarf (WD; J – L&apos; = 0.76 ± 0.19 mag, K – L&apos; = 0.64 ± 0.20). New model fits to the object&apos;s spectral energy distribution indicate a temperature T {sub eff} = 4260 ± 360 K, surface gravity log g = 7.94 ± 0.03, a cooling age t{sub c} ≈ 7.8 Gyr, and mass M = 0.54 ± 0.01 M {sub ☉}. We find that the cooling ages given by theoretical atmospheric models do not agree with the age of HD 114174 A derived from both isochronological and gyrochronological analyses. We speculate on possible scenarios to explain the apparent age discrepancy between the primary and secondary. HD 114174 B is a nearby benchmark WD that will ultimately enable a dynamical mass estimate through continued Doppler and astrometric monitoring. Efforts to characterize its physical properties in detail will test theoretical atmospheric models and improve our understanding of WD evolution, cooling, and progenitor masses.

A supramolecular &apos;'Double-cable'&apos; structure with a 129{sub 44} helix in a columnar porphyrin-C{sub 60} dyad and its application in polymer solar cells

Energy Technology Data Exchange (ETDEWEB)

Wang, Chien-Lung [College of Polymer Science and Polymer Engineering, The University of Akron, Akron, OH (United States); Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan (China); Zhang, Wen-Bin; Sun, Hao-Jan; Van Horn, Ryan M.; Kulkarni, Rahul R.; Tsai, Chi-Chun; Gong, Xiong; Cheng, Stephen Z.D. [College of Polymer Science and Polymer Engineering, The University of Akron, Akron, OH (United States); Hsu, Chain-Shu [Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan (China); Lotz, Bernard [Institut Charles Sadron, Strasbourg (France)

2012-11-15

A novel porphyrin-C{sub 60} dyad (PCD1) is designed and synthesized to investigate and manipulate the supramolecular structure where geometrically isotropic [such as [60]fullerene (C{sub 60})] and anisotropic [such as porphyrin (Por)] units coexist. It is observed that PCD1 possesses an enantiomeric phase behavior. The melting temperature of the stable PCD1 thermotropic phase is 160 C with a latent heat ({Delta}H) of 18.5 kJ mol{sup -1}. The phase formation is majorly driven by the cooperative intermolecular Por-Por and C{sub 60}-C{sub 60} interactions. Structural analysis reveals that this stable phase possesses a supramolecular &apos;'double-cable'&apos; structure with one p-type Por core columnar channel and three helical n-type C{sub 60} peripheral channels. These &apos;'double-cable'&apos; columns further pack into a hexagonal lattice with a = b = 4.65 nm, c = 41.3 nm, {alpha} = {beta} = 90 , and {gamma} = 120 . The column repeat unit is determined to possess a 129{sub 44} helix. With both donor (D; Pro) and acceptor (A; C{sub 60}) units having their own connecting channels as well as the large D/A interface within the supramolecular &apos;'double-cable'&apos; structure, PCD1 has photogenerated carriers with longer lifetimes compared to the conventional electron acceptor [6,6]-phenyl-C{sub 61}-butyric acid methyl ester. A phase-separated columnar morphology is observed in a bulk-heterojunction (BHJ) material made by the physical blend of a low band-gap conjugated polymer, poly[2,6-(4,4-bis-(2-ethylhexyl)-4H-cyclopenta [2,1-b;3,4-b&apos;]-dithiophene)-alt-4,7-(2,1,3-benzothia-diazole)] (PCPDTBT), and PCD1. With a specific phase structure in the solid state and in the blend, PCD1 is shown to be a promising candidate as a new electron acceptor in high performance BHJ polymer solar cells. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Development of a phoswich detector for neutron dose rate measurements in the Earth&apos;s atmosphere

Energy Technology Data Exchange (ETDEWEB)

Doensdorf, Esther Miriam

2014-04-30

The Earth is constantly exposed to a stream of energetic particles from outer space. Through the interaction of this radiation with the Earth&apos;s magnetosphere and atmosphere a complex radiation field is formed which varies with the location inside the Earth&apos;s atmosphere. This radiation field consists of charged and uncharged particles leading to the constant exposure of human beings to radiation. As this ionizing radiation can be harmful for humans, it is necessary to perform dose rate measurements in different altitudes in the Earth&apos;s atmosphere. Due to their higher biological effectiveness the exposure to neutrons is more harmful than the exposure to γ-rays and charged particles, which is why the determination of neutron dose rates is the focus of this work. In this work the prototype of a Phoswich detector called PING (Phoswich Instrument for Neutrons and Gammas) is developed to determine dose rates caused by neutrons in the Earth&apos;s atmosphere and to distinguish these from γ-rays. The instrument is composed of two different scintillators optically coupled to each other and read out by one common photomultiplier tube. The scintillator package consists of an inner plastic scintillator made of the material BC-412 and a surrounding anti-coincidence made of sodium doped caesium iodide (CsI(Na)). In this work the instrument is calibrated, tested and flown and a procedure for a pulse shape analysis for this instrument is developed. With this analysis it is possible to distinguish pulses from the plastic scintillator and pulses from the CsI(Na). The pulses from the plastic scintillator are mainly due to the interaction of neutrons but there is an energy-dependent contribution of γ-rays to these events. Measurements performed on board an airplane show that the dose rates measured with the developed detector are in the same order of magnitude as results of other instruments. During measurements on board stratospheric balloons the altitude dependence

Switzerland as Europe&apos;s &apos;'battery'&apos;. Wishful dream or reality?

International Nuclear Information System (INIS)

Kammer, Adrian; Zurmuehle, Damian; Salzmann, Michael; Baumgartner, Raphael; Mignone, Domenico

2015-01-01

There are plans for Swiss pumped hydrostorage systems to absorb large quantities of excess electricity from European wind and solar power generation. Model-based analyses have shown however that &apos;'Europe&apos;s battery&apos;&apos;, as Switzerland would like to see itself, will not be needed until the middle of this century. Even if all extension projects currently in progress should be completed, Switzerland will not have sufficient pump capacity or import capacity to absorb large amounts of excess electricity. Furthermore, the primary means of making storage capacity available for import electricity would be to reduce reservoir power plant capacity. In view of all this Switzerland&apos;s hopes for a role as a major European electricity storage provider appear somewhat exaggerated even in the long-term perspective.

&apos;Minergie&apos; as an opportunity for trade; &apos;Minergie&apos; als Chance fuer das Gewerbe

Energy Technology Data Exchange (ETDEWEB)

Graf, R.; Buergi, H.; Hotz, R.

2000-07-01

This collection of short articles is dedicated to the promotion of the Swiss &apos;Minergie&apos; building standard, covering the following points: &apos;Minergie&apos; - a standard for the future; well-insulated and air-tight - two of the three main &apos;Minergie&apos; requirements; solar collectors as a &apos;Minergie&apos; component; radiators for low-energy-consumption buildings; hot water from the sun on six out of seven days; the &apos;Minergie&apos; module as a factor for success; the &apos;Habitus&apos; ventilation unit - a new Swiss product. The first contribution introduces the &apos;Minergie&apos; Standard. Its application in the building and building technical services trades offers from considerable advantages and opportunities for profit. The Standard, which aims to increase the comfort and reduce the energy consumption of buildings, is introduced and the basic principles involved, including energy usage figures, are discussed. A second contribution describes two of the three main requirements for reaching the &apos;Minergie&apos; Standard, air-tightness and good thermal insulation. The main advantage of the standard - a higher level of comfort - is emphasised and an example is given. The third short article takes a look at the use of thermal solar collectors as a source of heat in &apos;Minergie&apos; buildings. A solution involving a combined solar heating and hot-water supply is discussed. The fourth contribution discusses the use of low-temperature radiators in &apos;Minergie&apos; buildings. Examples are given of heat requirements calculation and the factors involved in dimensioning the radiators are discussed. A fifth article describes a commercially available compact solar hot-water system and discusses questions of solar fraction. Returning to basic aspects, the sixth contribution introduces a labelling system for the various components of a &apos;Minergie&apos; building - such as ventilation units, insulation material, radiators, boilers etc

Thermal management of a &apos;'BC'&apos; size molicel

Energy Technology Data Exchange (ETDEWEB)

Fouchard, D.; Ruggier, L.; Taylor, B.J.

1987-05-01

The &apos;'BC'&apos; size MOLICEL using the rechargeable system Li/MoS/sub 2/ has already been shown to have performance characteristics appropriate for use in an electric vehicle battery. The cell design, based on the results of thermal modelling studies, has been modified to provide for improved removal of waste heat resulting from planned high power discharge or from accidental electrical abuse. Experimental verification of the various interfacial thermal impedances was done and an appropriate heat sink specified to use air cooling for the final rejection stage. Fully instrumented 45 Ah test cells were built using a design in which waste heat was caused to flow axially in the aluminum foils forming the cathode current collector. The bottom ends of these foils were thermally integrated to the cell can bottom which had air cooling fins attached externally. Two fully charged cells of this special design were subjected to sustained short circuit whilst being cooled on their fins only with air at 25 km/h. Neither cell experienced any excessive heat built-up and no safety hazard occurred. The results show that thermal management of this type of battery can readily be done using a simple cell design modification and requiring minimum complexity for heat disposal to the environment. The system does not impose any extraordinary constraints on electric vehicle design and it would also be feasible to duct warm air from the battery heat exchanger to provide passenger compartment heating. 17 figs., 7 tabs.

Validation of two fluoro-analogues of N,N-dimethyl-2-(2&apos;-amino-4&apos;-hydroxymethyl-phenylthio)benzylamine as serotonin transporter imaging agents using microPET

Energy Technology Data Exchange (ETDEWEB)

Jarkas, Nachwa; Voll, Ronald J.; Williams, Larry [Department of Radiology, Emory CSI, WWHC, Atlanta, GA 30329 (United States); Goodman, Mark M., E-mail: mgoodma@emory.ed [Department of Radiology, Emory CSI, WWHC, Atlanta, GA 30329 (United States)

2010-07-15

Introduction: Carbon-11 (C-11) N,N-dimethyl-2-(2&apos;-amino-4&apos;-hydroxymethyl-phenylthio)benzylamine ([{sup 11}C]HOMADAM) has been reported as highly specific and selective positron emission tomography (PET) radiotracer showing fast kinetics for the human brain serotonin transporter (SERT). In our continued effort to develop appropriate PET SERT radioligand that can be labeled with either C-11 or fluorine-18 (F-18), two new C-11 labeled analogues of HOMADAM, [{sup 11}C]-N,N-dimethyl-2-(2&apos;-amino-5&apos;-fluoro-4&apos;-hydroxymethyl-phenylthio) benzylamine ([{sup 11}C]-(2)) and [{sup 11}C]-N,N-dimethyl-2-(2&apos;-amino-4-fluoro-4&apos;-hydroxymethyl-phenylthio) benzylamine ([{sup 11}C]-(3)) have been synthesized and evaluated along the previously reported [{sup 11}C]-N,N-dimethyl-2-(2&apos;-amino-5-fluoro-4&apos;-hydroxymethyl-phenylthio) benzylamine ([{sup 11}C]-(1)). Methods: The in vitro competitive binding assays were performed in cells transfected with human SERT (hSERT), human dopamine transporter (hDAT), and human norepinephrine transporter (hNET). [{sup 11}C]-(2) and [{sup 11}C]-(3) were prepared by methylation of their monomethylbenzylamine precursors 13 and 22 with cyclotron produced [{sup 11}C]iodomethane ([{sup 11}C]CH{sub 3}I), respectively. Uptake and kinetics of [{sup 11}C]-(2) and [{sup 11}C]-(3) in the brain regions of interest were determined in anesthetized rhesus monkeys using Concorde microPET P4. Results: 2 and 3 displayed moderate and high affinity for the SERT with Kis (SERT) = 5.45 and 1.10 nM (vs [{sup 3}H]citalopram), respectively. After High Performance Liquid Chromatography (HPLC) purification, [{sup 11}C]-(2) and [{sup 11}C]-(3) were obtained in 23 and 9% radiochemical yield (RCY) and log Ps{sub 7.4} of 1.77 and 1.91, respectively. The microPET images of [{sup 11}C]-(2) and [{sup 11}C]-(3) showed clear localization in the monkey brain regions rich in SERT with midbrain to cerebellum ratios of 1.75 and 3.86 at 85 min post

A dorico order of architecture in Europe: &apos;&apos;At Lusitania... que mare attenticum spectrat...; A ordem dorica da arquitectura no nascer da Europa at Lusitania que Mare Atlanticum Speciat

Energy Technology Data Exchange (ETDEWEB)

Simoes, V.

2004-07-01

Investigating the Enigmatic Tower of Centum Celas, in it, the Precepts of the Doric Order of the Greek Architecture: the Pentagram, of the Divine Proportion, (the golden number: ? = 1,618); the Thermic Comfort of the Veranda Porch;. Near Centum Celas I discovered a primitive Greek Temple of same period (C. VI cent, B. C.), in the Lusitanian Gold and Tin Route Archetypes of the Patrimony of Human Childhood. In my opinion, our historians and archiologists have paid little attention to the migrations of what I call the Si(self) Arian of the Euro-Asian steppes, to the Neolithic&apos;s Communities of the Middle East and which was by them baptised Iberia. However the Si (self) Ariano turns European, with a man mutation, with the Greek thalassocracy, from Asian Troya to Occident Troia, where the Tagus flows into the sea. (Author)

Economies of scale versus economies of density in the electricity distribution. A quantitative analysis; Economie di scala versus economie di densita&apos; nella distribuzione elettrica. Un&apos;analisi quantitativa

Energy Technology Data Exchange (ETDEWEB)

Gulli' , F. [IEFE, Universita' Bocconi, Milan (Italy)

2000-06-01

The aim of this article is to analyse the costs of the electricity distribution in Italy. The case examined (Enel&apos;s distribution activity) is particularly interesting. In fact the specific organization of Enel allows to separate the effects of firm scale from the influence of the customers territorial concentration (territorial density). On this subject, the results of the econometric analysis shows that density economics are more important than scale economics. [Italian] L&apos;obiettivo di questo articolo e&apos; analizzare i costi nell&apos;attivita&apos; di distribuzione elettrica in Italia. Il caso esaminato, la distribuzione dell&apos;Enel, e&apos; a questo proposito particolarmente interessante, grazie alla specifica organizzazione dell&apos;Enel che prevede la presenza di centri di gestione gerarchicamente separati. E&apos; stato cosi&apos; possibile distinguere nettamente fra effetti dovuti alla scala produttiva ed effetti connessi alla concentrazione territoriale dell&apos;utenza (effetti di densita&apos;). Il modello econometrico costruito sui dati dell&apos;Enel ha, al riguardo, permesso di verificare che le economie di densita&apos; sono piu&apos; importanti di quelle di scala.