WorldWideScience

Sample records for hui-chen chou pi-hua

  1. Chou-Yang model and PHI form factor

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem; Saleem, M.; Rafique, M.

    1988-03-01

    By using the deduced differential cross-section data for PHIp elastic scattering at 175 GeV/c in the Chou-Yang model, the PHI form factor has been computed and parametrized. Then in conjunction with the proton form factor this form factor is used in the pristine Chou-Yang model to obtain differential cross-section data at Fermilab energies. The theoretical results agree with the experimental measurements, endorsing the conjecture that the hadronic form factor of neutral particle is proportional to its magnetic form factor.

  2. Generalised Chou-Yang model and recent results

    International Nuclear Information System (INIS)

    Fazal-e-Aleem; Rashid, H.

    1995-09-01

    It is shown that most recent results of E710 and UA4/2 collaboration for the total cross section and ρ together with earlier measurements give good agreement with measurements for the differential cross section at 546 and 1800 GeV the framework of Generalised Chou-Yang model. These results are also compared with the predictions of other models. (author). 16 refs, 2 figs

  3. Generalised Chou-Yang model and recent results

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem [International Centre for Theoretical Physics, Trieste (Italy); Rashid, H. [Punjab Univ., Lahore (Pakistan). Centre for High Energy Physics

    1996-12-31

    It is shown that most recent results of E710 and UA4/2 collaboration for the total cross section and {rho} together with earlier measurements give good agreement with measurements for the differential cross section at 546 and 1800 GeV within the framework of Generalised Chou-Yang model. These results are also compared with the predictions of other models. (author) 16 refs.

  4. Generalised Chou-Yang model and recent results

    International Nuclear Information System (INIS)

    Fazal-e-Aleem; Rashid, H.

    1996-01-01

    It is shown that most recent results of E710 and UA4/2 collaboration for the total cross section and ρ together with earlier measurements give good agreement with measurements for the differential cross section at 546 and 1800 GeV within the framework of Generalised Chou-Yang model. These results are also compared with the predictions of other models. (author)

  5. National Security Strategy: Examining Chou En Lai's Rapprochement with the United States

    National Research Council Canada - National Science Library

    Hartwick, Douglas A

    1993-01-01

    .... Relying on his diplomatic skill, pragmatism, and understanding of American and Soviet objectives, Chou engineered President Nixon's visit to China in February 1972 that was capped by the Shanghai Communique...

  6. Generalized Chou-Yang model for p(antip)p and. lambda. (anti. lambda. )p elastic scattering at high energies

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Fazal-E-Aleem; Azhar, I.A.

    1988-06-01

    The various characteristics of pp and antipp elastic scattering at high energies are explained by using the generalized Chou-Yang model which takes into consideration the anisotropic scattering of objects constituting colliding particles. The model is also used to extract the form factor and radius of the ..lambda.. particle.

  7. Wavelet images and Chou's pseudo amino acid composition for protein classification.

    Science.gov (United States)

    Nanni, Loris; Brahnam, Sheryl; Lumini, Alessandra

    2012-08-01

    The last decade has seen an explosion in the collection of protein data. To actualize the potential offered by this wealth of data, it is important to develop machine systems capable of classifying and extracting features from proteins. Reliable machine systems for protein classification offer many benefits, including the promise of finding novel drugs and vaccines. In developing our system, we analyze and compare several feature extraction methods used in protein classification that are based on the calculation of texture descriptors starting from a wavelet representation of the protein. We then feed these texture-based representations of the protein into an Adaboost ensemble of neural network or a support vector machine classifier. In addition, we perform experiments that combine our feature extraction methods with a standard method that is based on the Chou's pseudo amino acid composition. Using several datasets, we show that our best approach outperforms standard methods. The Matlab code of the proposed protein descriptors is available at http://bias.csr.unibo.it/nanni/wave.rar .

  8. Integrating Satellite Image Identification and River Routing Simulation into the Groundwater Simulation of Chou-Shui Basin

    Science.gov (United States)

    Yao, Y.; Yang, S.; Chen, Y.; Chang, L.; Chiang, C.; Huang, C.; Chen, J.

    2012-12-01

    Many groundwater simulation models have been developed for Chou-Shui River alluvial fan which is one of the most important groundwater areas in Taiwan. However, the exchange quantity between Chou-Shui River, the major river in this area, and the groundwater system itself is seldom studied. In this study, the exchange is evaluated using a river package (RIV) in the groundwater simulation model, MODFLOW 2000. Several critical parameters and variables used in RIV such as wet area and river level for each cell below the Chou-Shui River are respectively determined by satellite image identification and HEC-RAS simulation. The monthly average of river levels obtained from four stations include Chang-Yun Bridge, Xi-Bin Bridge, Chi-Chiang Bridge and Si-Jou Bridge during 2008 and the river cross-section measured on December 2007 are used in the construction of HEC-RAS model. Four FORMOSAT multispectral satellite images respectively obtained on January 2008, April 2008, July 2008, and November 2008 are used to identify the wet area of Chou-Shui River during different seasons. Integrating the simulation level provided by HEC-RAS and the identification result are used as the assignment of RIV. First, based on the simulation results of HEC-RAS, the water level differences between flooding period and draught period are 1.4 (m) and 2.0 (m) for Xi-Bin Bridge station (downstream) and Chang-Yun Bridge station (upstream) respectively. Second, based on the identified results, the wet areas for four seasons are 24, 24, 40 and 12 (km2) respectively. The variation range of areas in 2008 is huge that the area for winter is just 30% of the area for summer. Third, based on the simulation of MODFLOW 2000 and RIV, the exchange between the river and the groundwater system is 414 million cubic meters which contains 526 for recharge to river and 112 for discharging from river during 2008. The total recharge includes river exchange and recharge from non-river area is 2023 million cubic meters. The

  9. Prediction of protein structural classes by Chou's pseudo amino acid composition: approached using continuous wavelet transform and principal component analysis.

    Science.gov (United States)

    Li, Zhan-Chao; Zhou, Xi-Bin; Dai, Zong; Zou, Xiao-Yong

    2009-07-01

    A prior knowledge of protein structural classes can provide useful information about its overall structure, so it is very important for quick and accurate determination of protein structural class with computation method in protein science. One of the key for computation method is accurate protein sample representation. Here, based on the concept of Chou's pseudo-amino acid composition (AAC, Chou, Proteins: structure, function, and genetics, 43:246-255, 2001), a novel method of feature extraction that combined continuous wavelet transform (CWT) with principal component analysis (PCA) was introduced for the prediction of protein structural classes. Firstly, the digital signal was obtained by mapping each amino acid according to various physicochemical properties. Secondly, CWT was utilized to extract new feature vector based on wavelet power spectrum (WPS), which contains more abundant information of sequence order in frequency domain and time domain, and PCA was then used to reorganize the feature vector to decrease information redundancy and computational complexity. Finally, a pseudo-amino acid composition feature vector was further formed to represent primary sequence by coupling AAC vector with a set of new feature vector of WPS in an orthogonal space by PCA. As a showcase, the rigorous jackknife cross-validation test was performed on the working datasets. The results indicated that prediction quality has been improved, and the current approach of protein representation may serve as a useful complementary vehicle in classifying other attributes of proteins, such as enzyme family class, subcellular localization, membrane protein types and protein secondary structure, etc.

  10. Anti-pp,. cap alpha cap alpha. and p. cap alpha. elastic scattering at high energies and Chou-Yang conjecture

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Fazal-e-Aleem; Rifique, M.

    1987-03-01

    The recent experimental measurements for anti-pp and ..cap alpha cap alpha.. elastic scattering at high energies have shown that the Chou-Yang conjecture regarding the relationship between the electromagnetic and the hadronic form factor of a particle is only an approximation. A new ansatz has been proposed to obtain hadronic form factors of proton and the ..cap alpha..-particle. These form factors have been used to explain the various characteristics of anti-pp, ..cap alpha cap alpha.. and p..cap alpha.. elastic scattering at high energies.

  11. Analysis of p-bar p scattering at 31 GeV and 62 GeV by the Chou-Yang model

    International Nuclear Information System (INIS)

    Padua, A.B. de; Covolan, R.J.M.; Souza Paes, J.T. de

    1988-01-01

    The p-bar p scattering is analysed at 31 GeV and 62 GeV energies for momentum transfers in the range O 2 . The experimental (dσ/dt)p-bar p values were fitted using a pure imaginary written as a sum of exponentials, that is, a(s,t)=a(s,O) σ n i=l α i e βit . Using the parameters obtained we have calculated the absorption constant K p-bar p the form factor and the mean square radius of the p-bar matter distribuition by the Chou-Yang model. These calculations reveal a ''dip'' around -t approx.= 1.3 (GeV/c) 2 at 31 GeV and 62 GeV. (author) [pt

  12. GOASVM: a subcellular location predictor by incorporating term-frequency gene ontology into the general form of Chou's pseudo-amino acid composition.

    Science.gov (United States)

    Wan, Shibiao; Mak, Man-Wai; Kung, Sun-Yuan

    2013-04-21

    Prediction of protein subcellular localization is an important yet challenging problem. Recently, several computational methods based on Gene Ontology (GO) have been proposed to tackle this problem and have demonstrated superiority over methods based on other features. Existing GO-based methods, however, do not fully use the GO information. This paper proposes an efficient GO method called GOASVM that exploits the information from the GO term frequencies and distant homologs to represent a protein in the general form of Chou's pseudo-amino acid composition. The method first selects a subset of relevant GO terms to form a GO vector space. Then for each protein, the method uses the accession number (AC) of the protein or the ACs of its homologs to find the number of occurrences of the selected GO terms in the Gene Ontology annotation (GOA) database as a means to construct GO vectors for support vector machines (SVMs) classification. With the advantages of GO term frequencies and a new strategy to incorporate useful homologous information, GOASVM can achieve a prediction accuracy of 72.2% on a new independent test set comprising novel proteins that were added to Swiss-Prot six years later than the creation date of the training set. GOASVM and Supplementary materials are available online at http://bioinfo.eie.polyu.edu.hk/mGoaSvmServer/GOASVM.html. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. 影响公益众筹中项目筹款能力的一些相关因素--以众筹网为例%Some Related Factors Affecting the Ability to Raise Funds in the Crowdfunding of the Public Service---A Case Study of the ZhongChou Network

    Institute of Scientific and Technical Information of China (English)

    苟爱萍; 田江

    2016-01-01

    随着众筹融资和“互联网+”的发展,公益众筹开始兴起,文中通过爬虫软件获取了截至2016年6月22日众筹网所有成功结束的筹款项目的数据,通过数据分析发现了不同性质的公益项目在众筹过程中具有不同的优势,并且通过SPSS进行了数据间简单的相关性分析,发现了影响公益众筹能力的一些相关性因素和非相关因素,研究了项目信息的透明度,回报捐助的方式以及关注度对一个公益筹款项目的影响。%With the development of the Crowdfunding and“Internet plus”,the Crowdfunding of the public service begin to develop.This paper achieved all the datas of the successful public service projects in the ZhongChou network until June 22,2016 using the crawler software.Through the data analysis found that the different nature of the public service projects in the process of raising the fund has a different advantage,and through the simple correlation analysis using SPSS,found some related factors and non-related factors that affect the ability to raise fund in Crowdfunding of the public service,the influence of the transparency of project information,the way of return and the degree of concern on a public service project.

  14. Novel Technique for Safe Primary Trocar Insertion in Laparoscopy: Chou's Method

    Directory of Open Access Journals (Sweden)

    Pan-Hsin Chou

    2005-06-01

    Conclusion: The results with this novel method incorporating the unique concept of directly holding the fascia suggest it to be relatively safe, simple, and economic. The risk of major vascular injury was decreased to nil by this technique and the chance of visceral injury was also minimal.

  15. Prediction of Protein Submitochondrial Locations by Incorporating Dipeptide Composition into Chou's General Pseudo Amino Acid Composition.

    Science.gov (United States)

    Ahmad, Khurshid; Waris, Muhammad; Hayat, Maqsood

    2016-06-01

    Mitochondrion is the key organelle of eukaryotic cell, which provides energy for cellular activities. Submitochondrial locations of proteins play crucial role in understanding different biological processes such as energy metabolism, program cell death, and ionic homeostasis. Prediction of submitochondrial locations through conventional methods are expensive and time consuming because of the large number of protein sequences generated in the last few decades. Therefore, it is intensively desired to establish an automated model for identification of submitochondrial locations of proteins. In this regard, the current study is initiated to develop a fast, reliable, and accurate computational model. Various feature extraction methods such as dipeptide composition (DPC), Split Amino Acid Composition, and Composition and Translation were utilized. In order to overcome the issue of biasness, oversampling technique SMOTE was applied to balance the datasets. Several classification learners including K-Nearest Neighbor, Probabilistic Neural Network, and support vector machine (SVM) are used. Jackknife test is applied to assess the performance of classification algorithms using two benchmark datasets. Among various classification algorithms, SVM achieved the highest success rates in conjunction with the condensed feature space of DPC, which are 95.20 % accuracy on dataset SML3-317 and 95.11 % on dataset SML3-983. The empirical results revealed that our proposed model obtained the highest results so far in the literatures. It is anticipated that our proposed model might be useful for future studies.

  16. Mining microsatellite markers from public expressed sequence tag

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 91; Issue 3. Mining microsatellite markers from public expressed sequence tag sequences for genetic diversity analysis in pomegranate. Zai-Hai Jian Xin-She Liu Jian-Bin Hu Yan-Hui Chen Jian-Can Feng. Research Note Volume 91 Issue 3 December 2012 pp 353-358 ...

  17. Drinking Water Quality Criterion - Based site Selection of Aquifer Storage and Recovery Scheme in Chou-Shui River Alluvial Fan

    Science.gov (United States)

    Huang, H. E.; Liang, C. P.; Jang, C. S.; Chen, J. S.

    2015-12-01

    Land subsidence due to groundwater exploitation is an urgent environmental problem in Choushui river alluvial fan in Taiwan. Aquifer storage and recovery (ASR), where excess surface water is injected into subsurface aquifers for later recovery, is one promising strategy for managing surplus water and may overcome water shortages. The performance of an ASR scheme is generally evaluated in terms of recovery efficiency, which is defined as percentage of water injected in to a system in an ASR site that fulfills the targeted water quality criterion. Site selection of an ASR scheme typically faces great challenges, due to the spatial variability of groundwater quality and hydrogeological condition. This study proposes a novel method for the ASR site selection based on drinking quality criterion. Simplified groundwater flow and contaminant transport model spatial distributions of the recovery efficiency with the help of the groundwater quality, hydrological condition, ASR operation. The results of this study may provide government administrator for establishing reliable ASR scheme.

  18. Protein sequence analysis by incorporating modified chaos game and physicochemical properties into Chou's general pseudo amino acid composition.

    Science.gov (United States)

    Xu, Chunrui; Sun, Dandan; Liu, Shenghui; Zhang, Yusen

    2016-10-07

    In this contribution we introduced a novel graphical method to compare protein sequences. By mapping a protein sequence into 3D space based on codons and physicochemical properties of 20 amino acids, we are able to get a unique P-vector from the 3D curve. This approach is consistent with wobble theory of amino acids. We compute the distance between sequences by their P-vectors to measure similarities/dissimilarities among protein sequences. Finally, we use our method to analyze four datasets and get better results compared with previous approaches. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Prediction of citrullination sites by incorporating k-spaced amino acid pairs into Chou's general pseudo amino acid composition.

    Science.gov (United States)

    Ju, Zhe; Wang, Shi-Yun

    2018-04-22

    As one of the most important and common protein post-translational modifications, citrullination plays a key role in regulating various biological processes and is associated with several human diseases. The accurate identification of citrullination sites is crucial for elucidating the underlying molecular mechanisms of citrullination and designing drugs for related human diseases. In this study, a novel bioinformatics tool named CKSAAP_CitrSite is developed for the prediction of citrullination sites. With the assistance of support vector machine algorithm, the highlight of CKSAAP_CitrSite is to adopt the composition of k-spaced amino acid pairs surrounding a query site as input. As illustrated by 10-fold cross-validation, CKSAAP_CitrSite achieves a satisfactory performance with a Sensitivity of 77.59%, a Specificity of 95.26%, an Accuracy of 89.37% and a Matthew's correlation coefficient of 0.7566, which is much better than those of the existing prediction method. Feature analysis shows that the N-terminal space containing pairs may play an important role in the prediction of citrullination sites, and the arginines close to N-terminus tend to be citrullinated. The conclusions derived from this study could offer useful information for elucidating the molecular mechanisms of citrullination and related experimental validations. A user-friendly web-server for CKSAAP_CitrSite is available at 123.206.31.171/CKSAAP_CitrSite/. Copyright © 2017. Published by Elsevier B.V.

  20. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 36; Issue 4. Investigation of localization effect in GaN-rich InGaN alloys and modified band-tail model. Chuan-Zhen Zhao Bin Liu De-Yi Fu Hui Chen Ming Li Xiang-Qian Xiu Zi-Li Xie Shu-Lin Gu You-Dou Zheng. Volume 36 Issue 4 August 2013 pp 619-622 ...

  1. Hobbes, les pirates et les corsaires. Le « Léviathan échoué » selon Carl Schmitt

    Directory of Open Access Journals (Sweden)

    Dominique Weber

    2005-04-01

    Full Text Available Parmi les nombreux problèmes que pose l’ouvrage de Carl Schmitt Le Léviathan dans la doctrine de l’État de Thomas Hobbes, il en est un, majeur, qui concerne l’utilisation de la « mythologie politique » pour expliquer la réalité ou les doctrines politiques. Il y a là, à n’en pas douter, l’expression de l’un des versants de l’irrationalisme de Schmitt. La thèse de l’auteur est très claire : parce que Hobbes ne possédait aucun « sens mythologique », il s’est trompé de monstre biblique, appelant Leviathan son traité consacré au pouvoir d’État, alors qu’il aurait dû l’appeler plus adéquatement Behemoth, manquant du coup la Meeresbild caractérisant l’Angleterre de son temps. La thèse peut paraître séduisante, elle s’appuie néanmoins sur un présupposé fort contestable, car Hobbes ne vise nullement à créer des mythes. Il s’agit donc d’interroger la théorisation hobbesienne de la piraterie, d’une part, et de la dissidence religieuse « sauvage », d’autre part, afin de montrer que le choix par Hobbes des monstres du Livre de Job est un choix rationnellement assumé.

  2. Predict subcellular locations of singleplex and multiplex proteins by semi-supervised learning and dimension-reducing general mode of Chou's PseAAC.

    Science.gov (United States)

    Pacharawongsakda, Eakasit; Theeramunkong, Thanaruk

    2013-12-01

    Predicting protein subcellular location is one of major challenges in Bioinformatics area since such knowledge helps us understand protein functions and enables us to select the targeted proteins during drug discovery process. While many computational techniques have been proposed to improve predictive performance for protein subcellular location, they have several shortcomings. In this work, we propose a method to solve three main issues in such techniques; i) manipulation of multiplex proteins which may exist or move between multiple cellular compartments, ii) handling of high dimensionality in input and output spaces and iii) requirement of sufficient labeled data for model training. Towards these issues, this work presents a new computational method for predicting proteins which have either single or multiple locations. The proposed technique, namely iFLAST-CORE, incorporates the dimensionality reduction in the feature and label spaces with co-training paradigm for semi-supervised multi-label classification. For this purpose, the Singular Value Decomposition (SVD) is applied to transform the high-dimensional feature space and label space into the lower-dimensional spaces. After that, due to limitation of labeled data, the co-training regression makes use of unlabeled data by predicting the target values in the lower-dimensional spaces of unlabeled data. In the last step, the component of SVD is used to project labels in the lower-dimensional space back to those in the original space and an adaptive threshold is used to map a numeric value to a binary value for label determination. A set of experiments on viral proteins and gram-negative bacterial proteins evidence that our proposed method improve the classification performance in terms of various evaluation metrics such as Aiming (or Precision), Coverage (or Recall) and macro F-measure, compared to the traditional method that uses only labeled data.

  3. Identification of Heat Shock Protein families and J-protein types by incorporating Dipeptide Composition into Chou's general PseAAC.

    Science.gov (United States)

    Ahmad, Saeed; Kabir, Muhammad; Hayat, Maqsood

    2015-11-01

    Heat Shock Proteins (HSPs) are the substantial ingredients for cell growth and viability, which are found in all living organisms. HSPs manage the process of folding and unfolding of proteins, the quality of newly synthesized proteins and protecting cellular homeostatic processes from environmental stress. On the basis of functionality, HSPs are categorized into six major families namely: (i) HSP20 or sHSP (ii) HSP40 or J-proteins types (iii) HSP60 or GroEL/ES (iv) HSP70 (v) HSP90 and (vi) HSP100. Identification of HSPs family and sub-family through conventional approaches is expensive and laborious. It is therefore, highly desired to establish an automatic, robust and accurate computational method for prediction of HSPs quickly and reliably. Regard, a computational model is developed for the prediction of HSPs family. In this model, protein sequences are formulated using three discrete methods namely: Split Amino Acid Composition, Pseudo Amino Acid Composition, and Dipeptide Composition. Several learning algorithms are utilized to choice the best one for high throughput computational model. Leave one out test is applied to assess the performance of the proposed model. The empirical results showed that support vector machine achieved quite promising results using Dipeptide Composition feature space. The predicted outcomes of proposed model are 90.7% accuracy for HSPs dataset and 97.04% accuracy for J-protein types, which are higher than existing methods in the literature so far. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  4. An alignment-free method to find similarity among protein sequences via the general form of Chou's pseudo amino acid composition.

    Science.gov (United States)

    Gupta, M K; Niyogi, R; Misra, M

    2013-01-01

    In this paper, we propose a method to create the 60-dimensional feature vector for protein sequences via the general form of pseudo amino acid composition. The construction of the feature vector is based on the contents of amino acids, total distance of each amino acid from the first amino acid in the protein sequence and the distribution of 20 amino acids. The obtained cosine distance metric (also called the similarity matrix) is used to construct the phylogenetic tree by the neighbour joining method. In order to show the applicability of our approach, we tested it on three proteins: 1) ND5 protein sequences from nine species, 2) ND6 protein sequences from eight species, and 3) 50 coronavirus spike proteins. The results are in agreement with known history and the output from the multiple sequence alignment program ClustalW, which is widely used. We have also compared our phylogenetic results with six other recently proposed alignment-free methods. These comparisons show that our proposed method gives a more consistent biological relationship than the others. In addition, the time complexity is linear and space required is less as compared with other alignment-free methods that use graphical representation. It should be noted that the multiple sequence alignment method has exponential time complexity.

  5. Exploring the experiences of older Chinese adults with comorbidities including diabetes: surmounting these challenges in order to live a normal life

    OpenAIRE

    Ho, Hsiu-Yu; Chen, Mei-Hui; Lou, Meei-Fang

    2018-01-01

    Hsiu-Yu Ho,1,2 Mei-Hui Chen,2,3 Meei-Fang Lou1 1School of Nursing, College of Medicine, National Taiwan University, 2Department of Nursing, Yuanpei University of Medical Technology, 3National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, Republic of China Background: Many people with diabetes have comorbidities, even multimorbidities, which have a far-reaching impact on the older adults, their family, and society. However, little is known of the experience of older adult...

  6. Multi-iPPseEvo: A Multi-label Classifier for Identifying Human Phosphorylated Proteins by Incorporating Evolutionary Information into Chou's General PseAAC via Grey System Theory.

    Science.gov (United States)

    Qiu, Wang-Ren; Zheng, Quan-Shu; Sun, Bi-Qian; Xiao, Xuan

    2017-03-01

    Predicting phosphorylation protein is a challenging problem, particularly when query proteins have multi-label features meaning that they may be phosphorylated at two or more different type amino acids. In fact, human protein usually be phosphorylated at serine, threonine and tyrosine. By introducing the "multi-label learning" approach, a novel predictor has been developed that can be used to deal with the systems containing both single- and multi-label phosphorylation protein. Here we proposed a predictor called Multi-iPPseEvo by (1) incorporating the protein sequence evolutionary information into the general pseudo amino acid composition (PseAAC) via the grey system theory, (2) balancing out the skewed training datasets by the asymmetric bootstrap approach, and (3) constructing an ensemble predictor by fusing an array of individual random forest classifiers thru a voting system. Rigorous cross-validations via a set of multi-label metrics indicate that the multi-label phosphorylation predictor is very promising and encouraging. The current approach represents a new strategy to deal with the multi-label biological problems, and the software is freely available for academic use at http://www.jci-bioinfo.cn/Multi-iPPseEvo. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Nuevos Miembros, Palabras del Académico José Félix Patiño Restrepo.

    Directory of Open Access Journals (Sweden)

    Jose Felix Patiño Restrepo

    2004-03-01

    Son numerosas las contribuciones de Quintero a la cirugía biliar. Una de especial significación es el manejo quirúrgico de las estenosis biliares benignas con la técnica de hepático-yeyunostomía en Y de Roux con asa subcutánea, descrita por Hao-Hui Chen. Con laboriosidad y gran honestidad intelectual, Quintero rescató para este autor del Colegio Médico de Pekín el debido crédito. Su serie de 75 casos operados con excelente resultado es una de las mayores en América Latina y tal vez en el mundo...

  8. 2722-IJBCS-Article-Djomaha Edwige Sidoine

    African Journals Online (AJOL)

    hp

    Le but de ce travail a été d'étudier l'effet des insecticides, des variétés de chou et des dates de semis sur la teigne du chou à Dschang. Bacillus thuringiensis a été pulvérisé sur le chou pour contrôler les insectes. Deux insecticides conventionnels (Cyperdim 220 EC et Cypercal 100 EC) ont été utilisés comme produits.

  9. 75 FR 4509 - Uniform Criteria for State Observational Surveys of Seat Belt Use

    Science.gov (United States)

    2010-01-28

    ... statistical issues: Ms. Chou-Lin Chen, Chief, Mathematical Analysis Division, National Center for Statistics..., Washington, DC 20590. Telephone number: 202-366-1048; E- mail: Chou-Lin.Chen@dot.gov . For legal issues: Ms..., and reduce burden. E. Paperwork Reduction Act Under the Paperwork Reduction Act of 1995, a person is...

  10. An Analysis of an Ultra-High Speed Content-Addressable Database Retrieval System

    National Research Council Canada - National Science Library

    Costianes, Peter

    2001-01-01

    This work presents a model for assessing the performance of a paradigm and its implementation first proposed by Chou, Detofsky, and Louri entitled Multiwavelength Optical Content-Addressable Parallel Processor (MW-OCAPP...

  11. USAF Summer Research Program - 1995 Summer Faculty Research Program Final Reports, Volume 5A, Wright Laboratory

    Science.gov (United States)

    1995-12-01

    Certification. Oliver Wight Publications, Inc. Essex Junction. 1993. Ishikawa , Kaoru . (Translation by David J. Lu) What is Total Quality Control? The Japanese...approximation to the eight-harness satin weave (8H SW) is made, following the mosaic model ( Ishikawa and Chou, 1983) which treats woven composites as cross...K. W. and Bailey, J. E. (1978) Journal of Material Science, Vol. 13, pp. 195. Ishikawa , T. and Chou, T. W. (1983) One-dimensional micromechanical

  12. The Assessment of Military Multitasking Performance: Validation of a Dual Task and Multitask Protocol

    Science.gov (United States)

    2013-09-01

    31. 25. van Donkelaar P, Osternig L, Chou LS: Attentional and biomechanical deficits interact after mild traumatic brain injury. Exerc Sport Sci...to 5-second rush, dive to a prone position, combat rolling. Visual target selection through weapon scope, rapid lateral dodging and back pedaling ...M240. 70 van Donkelaar P, Osternig L, Chou LS. Attentional and biomechanical deficits interact after mild traumatic brain injury. Exerc Sport Sci Rev

  13. Geometrical scaling vs factorizable eikonal models

    CERN Document Server

    Kiang, D

    1975-01-01

    Among various theoretical explanations or interpretations for the experimental data on the differential cross-sections of elastic proton-proton scattering at CERN ISR, the following two seem to be most remarkable: A) the excellent agreement of the Chou-Yang model prediction of d sigma /dt with data at square root s=53 GeV, B) the general manifestation of geometrical scaling (GS). The paper confronts GS with eikonal models with factorizable opaqueness, with special emphasis on the Chou-Yang model. (12 refs).

  14. Exploring the experiences of older Chinese adults with comorbidities including diabetes: surmounting these challenges in order to live a normal life

    Directory of Open Access Journals (Sweden)

    Ho HY

    2018-01-01

    Full Text Available Hsiu-Yu Ho,1,2 Mei-Hui Chen,2,3 Meei-Fang Lou1 1School of Nursing, College of Medicine, National Taiwan University, 2Department of Nursing, Yuanpei University of Medical Technology, 3National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, Republic of China Background: Many people with diabetes have comorbidities, even multimorbidities, which have a far-reaching impact on the older adults, their family, and society. However, little is known of the experience of older adults living with comorbidities that include diabetes. Aim: The aim of this study was to explore the experience of older adults living with comorbidities including diabetes. Methods: A qualitative approach was employed. Data were collected from a selected field of 12 patients with diabetes mellitus in a medical center in northern Taiwan. The data were analyzed by Colaizzi’s phenomenological methodology, and four criteria of Lincoln and Guba were used to evaluate the rigor of the study. Results: The following 5 themes and 14 subthemes were derived: 1 expecting to heal or reduce the symptoms of the disease (trying to alleviate the distress of symptoms and trusting in health practitioners combining the use of Chinese and Western medicines; 2 comparing complex medical treatments (differences in physician practices and presentation, conditionally adhering to medical treatment, and partnering with medical professionals; 3 inconsistent information (inconsistent health information and inconsistent medical advice; 4 impacting on daily life (activities are limited and hobbies cannot be maintained and psychological distress; and 5 weighing the pros and cons (taking the initiative to deal with issues, limiting activity, adjusting mental outlook and pace of life, developing strategies for individual health regimens, and seeking support. Surmounting these challenges in order to live a normal life was explored. Conclusion: This study found that the experience of older adults

  15. Presurgical EEG-fMRI in a complex clinical case with seizure recurrence after epilepsy surgery

    Directory of Open Access Journals (Sweden)

    Zhang J

    2013-07-01

    Full Text Available Jing Zhang,1 Qingzhu Liu,2 Shanshan Mei,2 Xiaoming Zhang,2 Xiaofei Wang,2 Weifang Liu,1 Hui Chen,1 Hong Xia,1 Zhen Zhou,1 Yunlin Li2 1School of Biomedical Engineering, Capital Medical University, Beijing, People's Republic of China; 2Department of Functional Neurology and Neurosurgery, Beijing Haidian Hospital, Beijing, People's Republic of China Abstract: Epilepsy surgery has improved over the last decade, but non-seizure-free outcome remains at 10%–40% in temporal lobe epilepsy (TLE and 40%–60% in extratemporal lobe epilepsy (ETLE. This paper reports a complex multifocal case. With a normal magnetic resonance imaging (MRI result and nonlocalizing electroencephalography (EEG findings (bilateral TLE and ETLE, with more interictal epileptiform discharges [IEDs] in the right frontal and temporal regions, a presurgical EEG-functional MRI (fMRI was performed before the intraoperative intracranial EEG (icEEG monitoring (icEEG with right hemispheric coverage. Our previous EEG-fMRI analysis results (IEDs in the left hemisphere alone were contradictory to the EEG and icEEG findings (IEDs in the right frontal and temporal regions. Thus, the EEG-fMRI data were reanalyzed with newly identified IED onsets and different fMRI model options. The reanalyzed EEG-fMRI findings were largely concordant with those of EEG and icEEG, and the failure of our previous EEG-fMRI analysis may lie in the inaccurate identification of IEDs and wrong usage of model options. The right frontal and temporal regions were resected in surgery, and dual pathology (hippocampus sclerosis and focal cortical dysplasia in the extrahippocampal region was found. The patient became seizure-free for 3 months, but his seizures restarted after antiepileptic drugs (AEDs were stopped. The seizures were not well controlled after resuming AEDs. Postsurgical EEGs indicated that ictal spikes in the right frontal and temporal regions reduced, while those in the left hemisphere became prominent

  16. Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells

    Directory of Open Access Journals (Sweden)

    Chen YH

    2013-07-01

    Full Text Available Ying-Hui Chen,1,2,* Jo-Yu Wang,3,* Bo-Syong Pan,3,4 Yi-Fen Mu,3 Meng-Shao Lai,3,4 Edmund Cheung So,5 Thian-Sze Wong,6 Bu-Miin Huang3,4 1Department of Anesthesia, Chi-Mei Medical Center, Liouying, 2Department of Nursing, Min-Hwei College of Health Care Management, 3Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, 4The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 5Department of Anesthesia, An Nan Hospital, China Medical University, Tainan, Taiwan; 6Department of Surgery, University of Hong Kong Medical Center, Faculty of Medicine, The University of Hong Kong, Hong Kong *Authors contributed equally to this work Purpose: The present study aims to investigate whether the combination treatment of cordycepin (an extracted pure compound from Cordyceps sinensis and cisplatin (a platinum-based chemotherapy drug has better apoptotic effect in head and neck squamous cell carcinoma (HNSCC. Methods: The apoptotic influences of cordycepin and/or cisplatin treatments to human OC3, OEC-M1, and FaDu HNSCC cells were investigated by morphological observations, viability assay, flow cytometry assay, and Western blotting methods. Results: Data showed that the cell death phenomenon increased as the dosage of cordycepin or cisplatin increased, and it appeared more in cordycepin plus cisplatin cotreatment among three cell lines. Cell survival rates significantly decreased as the dosage of cordycepin or cisplatin increased, and the better apoptotic effects were observed in cotreatment. Cell cycle analysis further demonstrated that percentages of subG1 cells in cordycepin or cisplatin treatments significantly increased, suggesting that cells underwent apoptosis, and cordycepin plus cisplatin induced many more subG1 cells. Furthermore, cordycepin or cisplatin induced caspase-8, caspase-9, caspase-3, and poly adenosine diphosphate-ribose polymerase protein cleavages, and stimulated c

  17. Delivery of antagomiR204-conjugated gold nanoparticles from PLGA sheets and its implication in promoting osseointegration of titanium implant in type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Liu X

    2017-09-01

    Full Text Available Xiangwei Liu,1,* Naiwen Tan,1,* Yuchao Zhou,1 Hongbo Wei,1,* Shuai Ren,1 Fan Yu,2 Hui Chen,3 Chengming Jia,4 Guodong Yang,5 Yingliang Song1 1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, 2Department of Prosthodontics, School of Stomatology, 3Department of Plastic Surgery, Tangdu Hospital, 4Department of Traditional Chinese Medicine, Xijing Hospital, 5Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, China *These authors contributed equally to this work Abstract: Impaired osseointegration of the implant remains the big hurdle for dental implant therapy in diabetic patients. In this study, the authors first identified that miR204 was strikingly highly expressed in the bone mesenchymal stem cells (BMSCs of diabetic rats. Forced expression of miR204 repressed the osteogenic potential of BMSCs, while inhibition of miR204 significantly increased the osteogenic capacity. Moreover, the miR204 inhibitor was conjugated with gold nanoparticles (AuNP-antagomiR204 and dispersed them in the poly(lactic-co-glycolic acid (PLGA solution. The AuNP-antagomiR204 containing PLGA solution was applied for coating the surface of titanium implant. Electron microscope revealed that an ultrathin sheet was formed on the surface of the implant, and the AuNPs were evenly dispersed in the coated PLGA sheet. Cellular experiments revealed that these encapsulated AuNP-antagomiR204 were able to be released from the PLGA sheet and uptaken by adherent BMSCs. In vivo animal study further confirmed that the AuNP-antagomiR204 released from PLGA sheet promoted osseointegration, as revealed by microcomputerized tomography (microCT reconstruction and histological assay. Taken together, this study established that miR204 misexpression accounted for the deficient

  18. Use of vectors in sequence analysis.

    Science.gov (United States)

    Ishikawa, T; Yamamoto, K; Yoshikura, H

    1987-10-01

    Applications of the vector diagram, a new type of representation of protein structure, in homology search of various proteins including oncogene products are presented. The method takes account of various kinds of information concerning the properties of amino acids, such as Chou and Fasman's probability data. The method can detect conformational similarities of proteins which may not be detected by the conventional programs.

  19. Reciprocal Tutoring: Design with Cognitive Load Sharing

    Science.gov (United States)

    Chou, Chih-Yueh; Chan, Tak-Wai

    2016-01-01

    "Reciprocal tutoring," as reported in "Exploring the design of computer supports for reciprocal tutoring" (Chan and Chou 1997), has extended the meaning and scope of "intelligent tutoring" originally implemented in stand alone computers. This research is a follow-up to our studies on a "learning companion…

  20. An Atomic Clock with 10 (exp -18) Instability

    Science.gov (United States)

    2013-09-13

    of the lattice la sers, eliminating residual Doppler effects from me chanical vibrations of the apparatus correlated with the experimental cycle, and...Parker, Metrologia 47, 1 10 (2010). 6. T. Rosenband et al., Science 319, 1808 1812 (2008). 7. C. W. Chou, D. B. Hume, J. C. J. Koelemeij, D. J. Wineland

  1. EFFICACITE DE L'HYDROXYDE DE CUIVRE CONTRE LA ...

    African Journals Online (AJOL)

    Repository Agriculture : 70081962. Idrissou-Touré M. 2014. Test d'efficacité du fongi- cide « IDEFIX 40 WP hydroxyde de cuivre. 65,6 g/100 g » contre la nervation noire du chou causée par Xanthomonas campestris pv. campestris. Mémoire de. Master professionnel en Sciences et. Techniques de Production Végétale, Uni-.

  2. Comments on "Geometrical features of the shielded fixed pole Pomeron at very high energies"

    CERN Document Server

    Fujisaki, H

    1975-01-01

    A recently proposed generalisation of the Chou Yang droplet model (see Fujisaki and Tsukahera, ibid., vol. 53, p.161, of 1975) succeeded in giving a good explanation of all pp elastic data available of CERN ISR. The geometrical features of both elastic and inelastic overlap functions in the model are examined. (3 refs).

  3. Le CRDI en Bolivie

    International Development Research Centre (IDRC) Digital Library (Canada)

    à un accord avaient échoué. En 2009 ... à la coopération entre les pays et à la gestion concertée ... scientifique, la quantité d'eau que chacun des ... internationale (CRDI et Agence canadienne ... politiques agroalimentaires et des structures.

  4. Univariate and Multivariate Specification Search Indices in Covariance Structure Modeling.

    Science.gov (United States)

    Hutchinson, Susan R.

    1993-01-01

    Simulated population data were used to compare relative performances of the modification index and C. Chou and P. M. Bentler's Lagrange multiplier test (a multivariate generalization of a modification index) for four levels of model misspecification. Both indices failed to recover the true model except at the lowest level of misspecification. (SLD)

  5. Research Article Special Issue

    African Journals Online (AJOL)

    2017-10-05

    Oct 5, 2017 ... ... control systems, dynamic systems and time-series prediction [3-7]. ..... MATLAB 7.11 running on a Core i5, 2.6GHz CPU with 4G RAM ..... [7] Dong F, Lei X, Chou W. A dynamic model and control method for a two-axis ...

  6. PATTERNS OF SEVEN AND COMPLICATED MALARIA IN CHILDREN

    African Journals Online (AJOL)

    GB

    found registered in the delivery logbook, their card number documented in the delivery logbook was used as an initial entry to access their chart (where the detailed ..... Eclampsia Trial. Lancet, 1995; 345: 1455–63. 25. Duley L, Henderson-Smart DJ, Walker GJ,. Chou D. Magnesium sulphate versus diazepam for eclampsia.

  7. Structural and Functional Studies on the Fusion and Attachment Envelope Glycoproteins of Nipah Virus and Hendra Virus

    Science.gov (United States)

    2003-01-01

    including measles virus (MeV), mumps virus, Sendai virus (SeV), Newcastle disease virus (NDV), rinderpest virus, canine distemper virus (CDV), human...Institute of Health, Bethesda, MD. Hut 102, MT2, MT4, and CEM human T cell lines were provided by Chou-Zen Giam, USUHS, Bethesda, MD. The human osteosarcoma

  8. Antiproton-proton elastic scattering at 1.8 TeV

    International Nuclear Information System (INIS)

    Fazal-e-Aleem; Saleem, M.; Yodh, G.B.

    1990-01-01

    The predictions, based on the generalized Chou-Yang model, are made for the most recent measurements of antiproton-proton elastic scattering at √s = 1.8 TeV. These results have been compared with the recent theoretical predictions of various models. (author)

  9. Anisotropy function for pion-proton elastic scattering

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, Mohammad; Fazal-e-Aleem; Rashid, Haris

    1988-09-01

    By using the generalised Chou-Yang model and the experimental data on ..pi../sup -/p elastic scattering at 200 GeV/c, the anisotropy function which reflects the non-isotropic nature of elastic scattering is computed for the reaction ..pi../sup -/p -> ..pi../sup -/p.

  10. Proton-proton elastic scattering at ultrahigh energies

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Shaukat, M.A.; Fazal-e-Aleem (University of the Punjab, Lahore (Pakistan). Dept. of Physics)

    1981-05-30

    The authors use a geometrical model of high-energy pp elastic scattering as proposed by Chou and Yong to analyse experimental data available at present and consider the predictions of the dipole pomeron model for pp elastic scattering at ultrahigh energies. Theoretical results for differential cross sections are compared with experimental data.

  11. Anisotropy function for proton-proton elastic scattering

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, Mohammad; Fazal-e-Aleem; Azhar, I.A. (Punjab Univ., Lahore (Pakistan). Centre for High Energy Physics)

    1990-07-01

    By using the generalized Chou-Yang model and the experimental data on pp elastic scattering at 53 GeV, the anisotropy function which reflects the non-isotropic nature of elastic scattering is computed for the reaction pp{yields}pp. (author).

  12. Anisotropy function for proton-proton elastic scattering

    International Nuclear Information System (INIS)

    Saleem, Mohammad; Fazal-e-Aleem; Azhar, I.A.

    1990-01-01

    By using the generalized Chou-Yang model and the experimental data on pp elastic scattering at 53 GeV, the anisotropy function which reflects the non-isotropic nature of elastic scattering is computed for the reaction pp→pp. (author)

  13. Antiproton-proton elastic scattering at 1. 8 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem; Saleem, M. (Punjab Univ., Lahore (Pakistan). Centre for High Energy Physics); Yodh, G.B. (California Univ., Irvine, CA (USA). Dept. of Physics)

    1990-11-01

    The predictions, based on the generalized Chou-Yang model, are made for the most recent measurements of antiproton-proton elastic scattering at {radical}s = 1.8 TeV. These results have been compared with the recent theoretical predictions of various models. (author).

  14. Anisotropy function for pion-proton elastic scattering

    International Nuclear Information System (INIS)

    Saleem, Mohammad; Fazal-e-Aleem; Rashid, Haris

    1988-01-01

    By using the generalised Chou-Yang model and the experimental data on π - p elastic scattering at 200 GeV/c, the anisotropy function which reflects the non-isotropic nature of elastic scattering is computed for the reaction π - p → π - p. (author)

  15. Fulltext PDF

    Indian Academy of Sciences (India)

    LiNbO3 crystal; semiconductor optical amplifier; optical logic gates; add and drop multi- plexer. ... Frequency-encoded NOT, OR and NOR logic operations ..... [13] M H Chou, I Brener, M M Fejer, E E Chaban and S B Christman, IEEE Photon.

  16. 194 Évaluation de l'efficacité de l'insecticide Tricel 480 EC ...

    African Journals Online (AJOL)

    PR BOKO

    phytosanitaires par les agriculteurs, induit l'apparition de populations résistantes de ravageurs tel que. Plutellaxylostella [4], des risques sanitaires importants tels que les résidus de pesticides et de nitrates dans les produits alimentaires et les sols [5]. Parmi ces cultures maraichères, le chou fait partie des plus attaquées par ...

  17. Breast Cancer and Early Onset Childhood Obesity: Cell Specific Gene Expression in Mammary Epithelia and Adipocytes

    Science.gov (United States)

    2007-07-01

    G, Lee AV, McCarty M, Van Horn K, Chu O, Chou YC, Yang J, Guzman RC, Nandi S, Talamantes F. Growth and characterization of N-methyl-N- nitrosourea ...G, Lee AV, McCarty M, et al. Growth and characteriza- tion of N-methyl-N- nitrosourea -induced mammary tumors in intact and ovariectomized rats

  18. On the absence of multiple dips in diffraction of high energy hadrons

    International Nuclear Information System (INIS)

    Malecki; Michalec, M.; Pallotta, M.

    1997-07-01

    An unorthodox insight into the structure of the geometrical Chou-Yang model explains the experimentally observed paradox of elastic diffraction of high energy hadrons without multiple dips. It is pointed out that the shadow scattering, away from the forward peak, is governed by small values of the coupling strength

  19. 77 FR 51106 - Request for Comments on a Renewal Information Collection

    Science.gov (United States)

    2012-08-23

    ... Paperwork Reduction Act of 1995 (44 U.S.C. 3501 et seq.), this notice announces that the Information... technology. Authority: The Paperwork Reduction Act of 1995; 44 U.S.C. chapter 35, as amended; and 49 CFR 1.48. Issued in Washington, DC, on July 25, 2012. Chou-Lin Chen, Office Director, Office of Traffic Records and...

  20. Using a Radical-Derived Character E-Learning Platform to Increase Learner Knowledge of Chinese Characters

    Science.gov (United States)

    Chen, Hsueh-Chih; Hsu, Chih-Chun; Chang, Li-Yun; Lin, Yu-Chi; Chang, Kuo-En; Sung, Yao-Ting

    2013-01-01

    The present study is aimed at investigating the effect of a radical-derived Chinese character teaching strategy on enhancing Chinese as a Foreign Language (CFL) learners' Chinese orthographic awareness. An e-learning teaching platform, based on statistical data from the Chinese Orthography Database Explorer (Chen, Chang, Chou, Sung, & Chang,…

  1. A Numerical Study of Cavitation Inception in Complex Flow Fields

    Science.gov (United States)

    2007-12-01

    report describes DYNAFLOW’s efforts over the past three years to develop and apply innovative methods to study and model the cavitation inception in...Marjollet, Fréchou, D., Fruman, D.H., Karimi, A., Kueny, J.L., Michel, J.M., La Cavitation. Mécanismes Physiques et Aspects Industrielles

  2. Research in Electronics - JSEP (Joint Services Electronics Program)

    Science.gov (United States)

    1982-04-01

    Laboratory Lexington, MA, May 1, 1981, P.L. Kelley, H. Fetterman * P. Tannenbaum, R. Osgood EGG Inc. Salem. MA, May 1, 1981, S. Goldberg. S. Friedman Los...Helvajian Thomas Fischer Michael Stuke Joseph Catanzarite Delroy Baugh Frough Shokoohi Thomas Watson Fanao Kong David Sumida Jim-Son Chou Julio

  3. Sleep apnea leading to Parkinson’s disease – an important association

    Directory of Open Access Journals (Sweden)

    Shafqat MN

    2017-06-01

    Full Text Available Muhammad Nabeel Shafqat,1 Muhammad Aadil,2 Maria Shoaib3 1Department of Medicine, University of Medical Sciences “Serafin Ruiz de Zarate” Villa Clara (UCMVC, Villa Clara, Cuba; 2Department of Psychiatry, Rush University Medical Center, Chicago, IL, USA; 3Department of Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan We read with great interest the recently published article “Sleep apnea and the subsequent risk of Parkinson disease: a 3-year nationwide population-based study” by Chou et al.1 The study is a step forward in understanding the underlying pathophysiology of Parkinson’s disease, the authors have deduced sleep apnea as one of the possible risk factors. View the original paper by Chou and colleagues.

  4. Acoustic Analyses of the Singing Vibrato in Traditional Peking Opera.

    Science.gov (United States)

    Han, Qichao; Zhang, Ruifeng

    2017-07-01

    China's traditional Peking Opera has four standard categories of roles: Sheng, Dan, Jing, and Chou, the singing vibrato of each displaying a different auditory effect. The audio and respiratory signals were recorded for two performers of the Qing Yi role, one of the Jing role, one of the Chou role, one of the Lao Sheng role, one of the Xiao Sheng role, and one of the Lao Dan role. The recordings gained eventually consisted of 24 representative songs from six roles. The rates and extents of vibrato, fundamental frequency, and rib cage signals were analyzed. Two findings were obtained: (1) the classical opera singing vibratos of China and Western countries are acoustically different from each other; and (2) in Peking Opera, the singing vibratos of different roles show significant acoustic differences. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  5. Stabilizing Protein Effects on the Pressure Sensitivity of Fluorescent Gold Nanoclusters

    Science.gov (United States)

    2016-01-13

    affected by the environment of the stabilizing protein, allowing these hybrid systems to act as sensors in many applications.2,9,14–19 This has led...Biosens Bioelectron. 2012;32:297–299. 8. Joseph D, Geckeler KE. Synthesis of highly fluorescent gold nanoclusters using egg white proteins. Colloids Surf...Chang HW, Chien YC, Hsiao JK, Cheng JT, Chou PT. Insulin -directed synthesis of fluorescent gold nanoclusters: preservation of insulin bioactivity and

  6. Psychopathological Processes Involved in Social Comparison, Depression, and Envy on Facebook

    OpenAIRE

    Aurel Pera

    2018-01-01

    Is Facebook utilization beneficial or detrimental for psychological well-being? I draw on outstanding research (e.g., Chou and Edge, 2012; Lin and Utz, 2015; Appel et al., 2016; Ehrenreich and Underwood, 2016; Vogel and Rose, 2016; Hu et al., 2017) to substantiate that examining other individuals’ positively presented material on Facebook may have detrimental consequences. Increasing comparisons on Facebook may generate feelings of envy, the latter being a significant process determining the ...

  7. Cryptanalysis and improvement of quantum secure communication network protocol with entangled photons for mobile communications

    International Nuclear Information System (INIS)

    Gao, Gan

    2014-01-01

    Recently, a communication protocol called controlled bidirectional quantum secret direct communication for mobile networks was proposed by Chou et al (2014 Mobile Netw. Appl. 19 121). We study the security of the proposed communication protocol and find that it is not secure. The controller, Telecom Company, may eavesdrop secret messages from mobile devices without being detected. Finally, we give a possible improvement of the communication protocol. (paper)

  8. Biofiltration as a Viable Alternative for Air Pollution Control at Department of Defense Surface Coating Facilities

    Science.gov (United States)

    2007-03-01

    Bacteria, fungi , algae, protozoa and viral organisms are all present in compost. The presence of these microorganisms precludes the need for their...effectiveness of cow and pig manure, wheat bran, and bagasse (fibrous material extracted from the juice of crushed stalks of sugar cane) (Chou and...countless types of microorganisms known to exist; those associated with biodegradation typically appear as either bacteria, fungi , or algae. For

  9. Single-Pilot Workload Management in Entry-Level Jets

    Science.gov (United States)

    2013-09-01

    attention among them in an intricate dance commonly referred to as multitasking or concurrent task management (Chou, Madhaven, & Funk, 1996; Hoover & Russ...if they were interested in participating. One hundred one pilots responded and were sent, via email , a copy of the NASA Informed Consent form and...comfortable multitasking and dividing their attention between things such as talking to ATC and mak- ing power adjustments during the descent. All seven of

  10. China: A Country Study.

    Science.gov (United States)

    1980-09-01

    matter if the cat is black or white; as long as it catches mice , it is a good cat." Alc’ng with the de-emphasis of ideology, CCI’ policies of pragma...The natives were discriminated against socially and politically. All important cen- tral and regional posts were monopolized by Mongols, who also...where they monopolized the foreign trade at the Chinese port of Guangzhou (Kuang-chou, or Canton). Soon the Spaniards arrived, followed by the

  11. Proton-proton elastic scattering at ultrahigh energies

    International Nuclear Information System (INIS)

    Saleem, M.; Shaukat, M.A.; Fazal-e-Aleem

    1981-01-01

    Recent experimental results on proton-proton elastic scattering at high energies are discussed in the context of the comments by Chou and Yang. There does not appear to be any tendency that the experimental results would agree with the predictions of the geometrical model even at ultrahigh energies. The angular distribution structure as described by using the dipole pomeron is consistent with the experimental data at presently available high energies and predicts results quite different from the geometrical model. (author)

  12. Proton-proton elastic scattering at ultrahigh energies

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Shaukat, M.A.; Fazal-e-Aleem (University of the Punjab, Lahore (Pakistan). Dept. of Physics)

    1981-05-30

    Recent experimental results on proton-proton elastic scattering at high energies are discussed in the context of the comments by Chou and Yang. There does not appear to be any tendency that the experimental results would agree with the predictions of the geometrical model even at ultrahigh energies. The angular distribution structure as described by using the dipole pomeron is consistent with the experimental data at presently available high energies and predicts results quite different from the geometrical model.

  13. An introduction to presheaves with transfers and motivic cohomology

    Energy Technology Data Exchange (ETDEWEB)

    Biglari, Shahram [Abdus Salam International Centre for Theoretical Physics, Trieste (Italy)

    2001-08-01

    The construction of motivic cohomology theories has generated a lot of new research activities in algebraic geometry in the last years. In this work some preliminary ideas of schemes and morphisms, some homological algebra in abelian categories and Grothendieck topologies are given.The connection between Milnor and Quillen K-theory of fields is defined as well as the motivic cohomology and Bloch's higher Chou groups.

  14. Biomedical Studies with the Free Electron Laser

    Science.gov (United States)

    1989-05-15

    and Berns. Mi. W. User pitotora- 26. Kestel. D.. And Chou. T. C. Tumer -localizing components of the ptirph% rin diation therapy of cancer following... cancer , (2) laser tissue interactions for the study of atherosclerosis, (3) pulsed laser effects on the eye, (4) laser application in genetic...these studies. Please refer to the appropriate article/abstract for further detail. 1. Dye plus laser photosensitization of cancer . Significant

  15. Santé visuelle en Tanzanie : Une huile essentielle | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    25 nov. 2016 ... Maïs, manioc et légumineuses; voilà les aliments principaux dans les campagnes de la Tanzanie. La viande est peu disponible pour les ruraux et ne cherchez pas au marché local des carottes, du chou frisé ou des courges ! Or, les produits animaux – particulièrement les abats –, les légumes verts et les ...

  16. An introduction to presheaves with transfers and motivic cohomology

    International Nuclear Information System (INIS)

    Biglari, Shahram

    2001-08-01

    The construction of motivic cohomology theories has generated a lot of new research activities in algebraic geometry in the last years. In this work some preliminary ideas of schemes and morphisms, some homological algebra in abelian categories and Grothendieck topologies are given.The connection between Milnor and Quillen K-theory of fields is defined as well as the motivic cohomology and Bloch's higher Chou groups

  17. STIR: Tailored Interfaces for High Strength Composites Across Strain Rates

    Science.gov (United States)

    2013-09-02

    matrices. Fibers have been functionalized by several processes including nitration ,8 metalation,13,14 organic solvent treatment15 and plasma...Chou “Carbon nanotube/carbon fiber hybrid multiscale composites”. J. Appl. Phys., Vol. 91, No. 9, pp 60346037, 2002. 4 Y. Lin, G. Ehlert and H...M. Itkis and R. Haddon “ Multiscale carbon nanotube-carbon fiber reinforcement for advanced epoxy composites”. Langmuir, Vol. 23, No. 7, pp 3970-3974

  18. The Three Wars of Lt. Gen. George E. Stratemeyer. His Korean War Diary

    Science.gov (United States)

    1999-01-01

    Craigies) that it would land tomorrow, 11 July at 1100 hours at Haneda.96 Annalee will meet them on my behalf complete with flowers and our offer of...At 1530 hours Colonel Lei107 (spelling ?) from Taiwan dropped in with General Banfill. He brought some pineapples from General Chou and greetings from...foreign service tour and be rotated only in accor- dance with FEAF policy. A recommendation for the Legion of Merit for Colonel Jennings is now in your

  19. Deuteron-deuteron elastic scattering at high energies

    International Nuclear Information System (INIS)

    Fazal-e-Aleem; Ali, S.

    1991-01-01

    The eikonal picture which has theoretical foundations in some areas of physics has been successful in explaining various aspects of elastic scattering at high energies. Chou and Yang first proposed a preliminary version of the eikonal model for hadron-hadron elastic scattering. The model is based on geometrical considerations in which hadrons are treated as extended objects. Elastic scattering then results from the propagation of attenuated wave function. By assuming that at high energies the scattering amplitude is purely imaginary and that the hadronic matter distribution is proportional to the charge distribution on protons, Durand and Lipes studied high energy pp scattering on the basis of this prestine model. Later on, the model was extended to other elastic reactions. However, a survey of literature shows that it has been successful only in the diffraction peak region. It has been shown that the pristine Chou-Yange model can explain the differential cross section for deuteron-deuteron elastic scattering at √s = 53 GeV in the diffraction peak region. In order to fit the large momentum transfer data, the generalized Chou-Yang model is used

  20. Borehole Data Package for 216-U-12 Crib Well 299-W22-79

    International Nuclear Information System (INIS)

    DG Horton; BA Williams

    1999-01-01

    One new Resource Conservation and Recovery Act (RCRA) groundwater monitoring well was installed at the 216-U-12 crib in September 1998 in support of Tri-Parly Agreement (Ecology 1996) milestone M-24-36. The new well is 299-W22-79 and is a downgradient well in the groundwater monitoring network. There are a total of six wells in the groundwater monitoring network for the 216-U-12 crib and their locations are shown on Figure 1. The groundwater assessment monitoring plan for the 216-U-12 crib (Chou and Williams 1993) describes the hydrogeology of the 200 West Area and the 216-U-12 crib area. An Interim Change Notice to the assessment plan provides justification for the well (Chou and Williams 1997). The new well was constructed to the specifications and requirements described in Washington Administrative Code (WAC) 173-160, and WAC-173-303, and in Chou and Williams (1997). This document compiles information on the drilling and construction, well development and permanent pump installation applicable to well 299-W22-79. Appendix A contains the geologist's log, the Well Construction Summary Report, and Well Summary Sheet (as-built diagram). Additional documentation concerning well construction is on file with Bechtel Hanford, Inc., Richland, Washington. English units are used in this report because they are used by drillers to measure and report depths and well construction details. The conversion is made by multiplying feet by 0.3048 to obtain meters; or multiplying inches by 2.54 to obtain centimeters

  1. Classical universe emerging from quantum cosmology without horizon and flatness problems

    Energy Technology Data Exchange (ETDEWEB)

    Fathi, M.; Jalalzadeh, S. [Shahid Beheshti University, Department of Physics, Tehran (Iran, Islamic Republic of); Moniz, P.V. [Centro de Matematica e Aplicacoes-UBI, Covilha (Portugal); Universidade da Beira Interior, Departmento de Fisica, Covilha (Portugal)

    2016-10-15

    We apply the complex de Broglie-Bohm formulation of quantum mechanics in Chou and Wyatt (Phys Rev A 76: 012115, 2007), Gozzi (Phys Lett B 165: 351, 1985), Bhalla et al. (Am J Phys 65: 1187, 1997) to a spatially closed homogeneous and isotropic early universe whose matter contents are radiation and dust perfect fluids. We then show that an expanding classical universe can emerge from an oscillating (with complex scale factor) quantum universe without singularity. Furthermore, the universe obtained in this process has no horizon or flatness problems. (orig.)

  2. Elemental analysis of ancient Chinese bronze artifacts with external-beam PIXE

    International Nuclear Information System (INIS)

    Lin, E.K.; Yu, Y.C.; Wang, C.W.; Shen, C.T.; Huang, Y.M.; Wu, S.C.; Hsieh, C.H.

    1992-01-01

    External-beam PIXE has been applied for the determination of the elemental composition of ancient Chinese bronze artifacts. Characteristic x-ray spectra from the samples bombarded with protons of 3 MeV have been measured with a HPGe detector. At each sample three spots were irradiated per run. Results of measurements on three fragments of bronze drinking vessels and helmet of Chinese ancient Chou and Shang dynasties (17th-8th century B.C.) are presented. To check the analytical method, we have also made measurements on the elemental composition of some modern coins. The results are discussed. (author)

  3. Four new species of the genus Mongoliana Distant (Hemiptera: Fulgoromorpha: Issidae) from southern China.

    Science.gov (United States)

    Meng, Rui; Wang, Yinglun; Qin, Daozheng

    2016-01-05

    Four new species in the planthopper genus Mongoliana Distant from southern China (Hemiptera: Fulgoromorpha: Issidae) are reported. Three of them, M. bistriata sp. nov., M. latistriata sp. nov. and M. albimaculata sp. nov., are described and illustrated; the fourth new one, M. arcuata sp. nov., is briefly described for M. triangularis Chen, Zhang & Chang which was a misidentification of M. triangularis Che, Wang & Chou. M. recurrens (Butler, 1875) is re-described and remarks for its current status is given. A key to all known species of Mongoliana is provided. The distribution and morphological peculiarities of the genus are briefly discussed.

  4. Description of a new genus, Galgoria gen. nov. (Hemiptera: Cicadidae: Cicadinae: Leptopsaltriini: Leptopsaltriina).

    Science.gov (United States)

    Lee, Young June

    2016-05-10

    A new cicada genus, Galgoria gen. nov., is described with Tanna herzbergi Schmidt, 1932 (from southern China) as its type species, which is placed in the subtribe Leptopsaltriina Moulton, 1923 of the tribe Leptopsaltriini Moulton, 1923 in the subfamily Cicadinae Latreille, 1802 (Hemiptera: Cicadidae). Tanna herzbergi Schmidt, 1932 is transferred from Tanna Distant, 1905 to Galgoria gen. nov. to become Galgoria herzbergi (Schmidt, 1932) comb. nov. Tanna apicalis Chen, 1940 syn. nov. and Tanna pseudocalis Lei & Chou, 1997 syn. nov. are synonymized here with Galgoria herzbergi (Schmidt, 1932) comb. nov.

  5. Pseudomembranous colitis within radiotherapy field following concurrent chemoradiation therapy: a case report

    OpenAIRE

    Hsieh, Chen-Hsi; Shen,Bing-Jie; Lin,Shih-Chiang; Shueng,Pei-Wei; Tseng,Li-Ming; Chou,

    2013-01-01

    Bing-Jie Shen,1 Shih-Chiang Lin,2 Pei-Wei Shueng,1,3 Yueh-Hung Chou,4 Li-Ming Tseng,5 Chen-Hsi Hsieh1,6,71Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Division of Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan; 3Department of Radiation Oncology, National Defense Medical Center, Taipei, Taiwan; 4Department of Anatomical Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan; 5...

  6. Go home, gay boy! Or, why do Singaporean gay men prefer to "go home" and not "come out"?

    Science.gov (United States)

    Tan, Chris K K

    2011-01-01

    Anglo-American ontologies posit that gay men should come out to match their outer selves with their inner ones. In Confucianized Singapore, however, gay men refrain from coming out to their parents to avoid shaming their families. Instead, they couch their homosexuality in kinship terms and "go home" with their boyfriends (Chou, 2000). "Going home" gains familial acceptance, but it does not challenge mainstream discourses of homosexuality. By examining how Singaporean gay men negotiate their sexuality with their families, I question the validity of coming out and going home as both ontological discourses and strategies.

  7. Effect of conformational propensity of peptide antigens in their interaction with MHC class II molecules. Failure to document the importance of regular secondary structures

    DEFF Research Database (Denmark)

    Sette, A; Lamont, A; Buus, S

    1989-01-01

    the binding capacity, but no correlation was found between their effect and their alpha-helical, beta-sheet, or beta-turn conformational propensity as calculated by the Chou and Fasman algorithm. In summary, all the data presented herein suggest that, at least in the case of OVA 323-336 and IAd......, the propensity of the antigen molecule to form secondary structures such as alpha-helices, beta-sheets, or beta-turns does not correlate with its capacity to bind MHC molecules....

  8. Characterization of the alpha and beta subunits of casein kinase 2 by far-UV CD spectroscopy

    DEFF Research Database (Denmark)

    Issinger, O G; Brockel, C; Boldyreff, B

    1992-01-01

    Although Chou-Fasman calculations of the secondary structure of recombinant casein kinase 2 subunits alpha and beta suggest they have a similar overall conformation, circular dichroism (CD) studies show that substantial differences in the conformation of the two subunits exist. In addition......, no changes in the far-UV CD spectrum of the alpha subunit are observed in the presence of casein or the synthetic decapeptide substrate RRRDDDSDDD. Furthermore, the alpha-helical structure of the alpha subunit (but not the beta subunit) can be increased in the presence of stoichiometric amounts of heparin...

  9. Elemental analysis of ancient Chinese bronze artifacts with external-beam PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Lin, E.K.; Yu, Y.C.; Wang, C.W.; Shen, C.T.; Huang, Y.M.; Wu, S.C.; Hsieh, C.H. [Academia Sinica, Taipei, TW (China). Inst. of Physics

    1992-12-31

    External-beam PIXE has been applied for the determination of the elemental composition of ancient Chinese bronze artifacts. Characteristic x-ray spectra from the samples bombarded with protons of 3 MeV have been measured with a HPGe detector. At each sample three spots were irradiated per run. Results of measurements on three fragments of bronze drinking vessels and helmet of Chinese ancient Chou and Shang dynasties (17th-8th century B.C.) are presented. To check the analytical method, we have also made measurements on the elemental composition of some modern coins. The results are discussed. (author).

  10. Music therapy-induced changes in salivary cortisol level are predictive of cardiovascular mortality in patients under maintenance hemodialysis

    OpenAIRE

    Hou, Yi-Chou; Lin, Yen-Ju; Lu, Kuo-Cheng; Chiang, Han-Sun; Chang, Chia-Chi; Yang, Li-King

    2017-01-01

    Yi-Chou Hou,1 Yen-Ju Lin,2 Kuo-Cheng Lu,1 Han-Sun Chiang,3 Chia-Chi Chang,4 Li-King Yang1 1Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 2Department of Nursing, Taipei Medical University, 3Graduate Institute of Basic Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, 4School of Gerontology Health Management, College of Nursing, Taipei Medical University, Taipei, Taiwan, Republic of China Background:...

  11. Targeting Signal Transducers and Activators of Transcription-3 (STAT3) as a Novel Strategy in Sensitizing Breast Cancer to EGFR-Targeted Therapy

    Science.gov (United States)

    2009-06-01

    Figure 4A). Using the Median-effect analysis (Chou and Talalay 1984) that computes combination index (CI), we determined whether AG490 and Iressa...H3578T cells were subjected Median-effect analysis to derive CI that indicates synergistic effect (CIə), additive effect (CI=1) and antagonistic effect...Wrzeszczynska, G. Devgan, Y. Zhao, R. G. Pestell , C. Albanese, and J. E. Darnell, Jr. 1999. Stat3 as an oncogene. Cell 98 (3):295-303. Chan, K. S., S. Sano, K

  12. Hadronic inelastic cross sections from analyses of the elastic channel

    International Nuclear Information System (INIS)

    Beggio, P.C.; Martini, A.F.; Menon, M.J.

    1997-01-01

    We present a comparative analysis of the Inelastic Overlap Functions predicted by three models for elastic scattering: Chou and Yang, Henzi and Valin and Martini and Menon. The results are also compared with two model independent extractions (Amaldi-Schubert and Carvalho-Menon). We then calculate the predictions for the corresponding integrated inelastic cross-sections from the three models and compare the results with the experimental data on pp and pp scattering available above 10 GeV. Similarities and differences between all modes predictions are presented and discussed. (author)

  13. The role of socio-cognitive variables in predicting learning satisfaction in smart schools

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Firoozi

    2017-03-01

    Full Text Available The present study aimed to investigate the role of Socio-Cognitive variables in predicting learning satisfaction in Smart Schools. The population was all the primary school students studying in smart schools in the city of Shiraz in the school year 2014-2015. The sample, randomly chosen through multi-stage cluster sampling, was 383 primary school students studying in smart schools in Shiraz. The instruments were the Computer Self-Efficiency Questionnaire developed by Torkzadeh (2003, Performance Expectation Questionnaire developed by Compeau and Higgins (1995, System Functionality and Content Feature Questionnaire developed by Pituch and Lee (2006, Interaction Questionnaire developed by Johnston, Killion and Oomen (2005, Learning Climate Questionnaire developed by Chou` and Liu (2005 and Learning Satisfaction Questionnaire developed by Chou and Liu (2005. In order to determine the possible relationship between variables and to predict the changes in the degree of satisfaction, we made use of correlational procedures and step-wise regression analysis. The results indicated that all the socio-cognitive variables have a positive and significant correlation with learning satisfaction. Out of the socio-cognitive variables in question, Computer Self-Efficiency, Performance Expectation and Learning Climate significantly explained 53% of the variance of learning satisfaction.

  14. The Role of Socio-Cognitive Variables in Predicting Learning Satisfaction in Smart Schools

    Directory of Open Access Journals (Sweden)

    Mohammad Reza FIROOZI

    2017-03-01

    Full Text Available The present study aimed to investigate the role of Socio-Cognitive variables in predicting learning satisfaction in Smart Schools. The population was all the primary school students studying in smart schools in the city of Shiraz in the school year 2014-2015. The sample, randomly chosen through multi-stage cluster sampling, was 383 primary school students studying in smart schools in Shiraz. The instruments were the Computer Self-Efficiency Questionnaire developed by Torkzadeh (2003, Performance Expectation Questionnaire developed by Compeau and Higgins (1995, System Functionality and Content Feature Questionnaire developed by Pituch and Lee (2006, Interaction Questionnaire developed by Johnston, Killion and Oomen (2005, Learning Climate Questionnaire developed by Chou` and Liu (2005 and Learning Satisfaction Questionnaire developed by Chou and Liu (2005. In order to determine the possible relationship between variables and to predict the changes in the degree of satisfaction, we made use of correlational procedures and step-wise regression analysis. The results indicated that all the socio-cognitive variables have a positive and significant correlation with learning satisfaction. Out of the socio-cognitive variables in question, Computer Self-Efficiency, Performance Expectation and Learning Climate significantly explained 53% of the variance of learning satisfaction.

  15. The approach of pp and pp-bar elastic scattering to ''asymptopia''

    International Nuclear Information System (INIS)

    Block, M.M.; Cahn, R.N.

    1985-01-01

    The authors study a gray disk model that reproduces these values of σ/sub tot/ and B. As an example, the impact parameter representations for these two models at √s = 40 TeV are shown. The corresponding elastic differential cross sections are shown. They note that when the diffraction minima are filled in by the contribution of the real amplitude (rho not equal to 0), the difference between the disk and the Chou-Yang model is small and would be hard to detect experimentally. In essence, at the SSC energy the Chou-Yang model has already gone over to a grey disk, with a negative curvature parameter, C = 1/2 (d/sup 2/(iota n d σ/dt)/dt/sup 2//sub t=0/. In contrast, at the SPS Collider energy, where C > 0, the differential cross sections are substantially different in the two models. If they define C = 0 as the onset of asymptopia for elastic scattering, they find this will occur near the Tevatron Collider energy, √s = 2 TeV

  16. Faults in Linux

    DEFF Research Database (Denmark)

    Palix, Nicolas Jean-Michel; Thomas, Gaël; Saha, Suman

    2011-01-01

    In 2001, Chou et al. published a study of faults found by applying a static analyzer to Linux versions 1.0 through 2.4.1. A major result of their work was that the drivers directory contained up to 7 times more of certain kinds of faults than other directories. This result inspired a number...... of development and research efforts on improving the reliability of driver code. Today Linux is used in a much wider range of environments, provides a much wider range of services, and has adopted a new development and release model. What has been the impact of these changes on code quality? Are drivers still...... a major problem? To answer these questions, we have transported the experiments of Chou et al. to Linux versions 2.6.0 to 2.6.33, released between late 2003 and early 2010. We find that Linux has more than doubled in size during this period, but that the number of faults per line of code has been...

  17. Recent progress in computational approaches to studying the M2 proton channel and its implication to drug design against influenza viruses.

    Science.gov (United States)

    Du, Qi-Shi; Huang, Ri-Bo

    2012-05-01

    For quite a long period of time in history, many intense efforts have been made to determine the 3D (three-dimensional) structure of the M2 proton channel. The reason why the M2 proton channel has attracted so many attentions is because (1) it is the key for really understanding the life cycle of influenza viruses, and (2) it is indispensable for conducting rational drug design against the flu viruses. Recently, the long-sough 3D structures of the M2 proton channels for both influenza A and B viruses were consecutively successfully determined by the high-resolution NMR spectroscopy (Schnell J.R. and Chou, J.J., Nature, 2008, 451: 591-595; Wang, J., Pielak, R.M., McClintock, M.A., and Chou, J.J., Nature Structural & Molecular Biology, 2009,16: 1267-1271). Such a milestone work has provided a solid structural basis for in-depth understanding the action mechanism of the M2 channel and rationally designing effective drugs against influenza viruses. This review is devoted to, with the focus on the M2 proton channel of influenza A, addressing a series of relevant problems, such as how to correctly understand the novel allosteric inhibition mechanism inferred from the NMR structure that is completely different from the traditional view, what the possible impacts are to the previous functional studies in this area, and what kind of new strategy can be stimulated for drug development against influenza.

  18. Google Scholar is not enough to be used alone for systematic reviews.

    Science.gov (United States)

    Giustini, Dean; Boulos, Maged N Kamel

    2013-01-01

    Google Scholar (GS) has been noted for its ability to search broadly for important references in the literature. Gehanno et al. recently examined GS in their study: 'Is Google scholar enough to be used alone for systematic reviews?' In this paper, we revisit this important question, and some of Gehanno et al.'s other findings in evaluating the academic search engine. The authors searched for a recent systematic review (SR) of comparable size to run search tests similar to those in Gehanno et al. We selected Chou et al. (2013) contacting the authors for a list of publications they found in their SR on social media in health. We queried GS for each of those 506 titles (in quotes "), one by one. When GS failed to retrieve a paper, or produced too many results, we used the allintitle: command to find papers with the same title. Google Scholar produced records for ~95% of the papers cited by Chou et al. (n=476/506). A few of the 30 papers that were not in GS were later retrieved via PubMed and even regular Google Search. But due to its different structure, we could not run searches in GS that were originally performed by Chou et al. in PubMed, Web of Science, Scopus and PsycINFO®. Identifying 506 papers in GS was an inefficient process, especially for papers using similar search terms. Has Google Scholar improved enough to be used alone in searching for systematic reviews? No. GS' constantly-changing content, algorithms and database structure make it a poor choice for systematic reviews. Looking for papers when you know their titles is a far different issue from discovering them initially. Further research is needed to determine when and how (and for what purposes) GS can be used alone. Google should provide details about GS' database coverage and improve its interface (e.g., with semantic search filters, stored searching, etc.). Perhaps then it will be an appropriate choice for systematic reviews.

  19. Heat transfer study under supercritical pressure conditions

    International Nuclear Information System (INIS)

    Yamashita, Tohru; Yoshida, Suguru; Mori, Hideo; Morooka, Shinichi; Komita, Hideo; Nishida, Kouji

    2003-01-01

    Experiments were performed on heat transfer and pressure drop of a supercritical pressure fluid flowing upward in a uniformly heated vertical tube of a small diameter, using HCFC22 as a test fluid. Following results were obtained. (1) Characteristics of the heat transfer are similar to those for the tubes of large diameter. (2) The effect of tube diameter on the heat transfer was seen for a 'normal heat transfer, but not for a 'deteriorated' heat transfer. (3) The limit heat flux for the occurrence of deterioration in heat transfer becomes larger with smaller diameter tube. (4) The Watts and Chou correlation has the best prediction performance for the present data in the 'normal' heat transfer region. (5) Frictional pressure drop becomes smaller than that for an isothermal flow in the region near the pseudocritical point, and this reduction was more remarkable for the deteriorated' heat transfer. (author)

  20. p-barp elastic scattering at high energies

    International Nuclear Information System (INIS)

    Padua, A.B. de.

    1986-01-01

    The p-bar p elastic scattering is analysed in the energy range 9.78 pp werefitted under the hypothesis of a pure imaginary amplitude and writted as a sum of exponentials, that is, a(s,t) = a(s,O) Σ n i=l α i exp β i t. Using the parameters a(s,O), α i and β i we obtained the absorption constante K- pp , the form factor and the mean square radius of the - p matter distribution by the Chou-Yang model. These calculations reveal a dip around -t ≅ 1.3 (GeV/c) 2 at 31 and 62 GeV. (author) [pt

  1. Prediction of beta-turns with learning machines.

    Science.gov (United States)

    Cai, Yu-Dong; Liu, Xiao-Jun; Li, Yi-Xue; Xu, Xue-biao; Chou, Kuo-Chen

    2003-05-01

    The support vector machine approach was introduced to predict the beta-turns in proteins. The overall self-consistency rate by the re-substitution test for the training or learning dataset reached 100%. Both the training dataset and independent testing dataset were taken from Chou [J. Pept. Res. 49 (1997) 120]. The success prediction rates by the jackknife test for the beta-turn subset of 455 tetrapeptides and non-beta-turn subset of 3807 tetrapeptides in the training dataset were 58.1 and 98.4%, respectively. The success rates with the independent dataset test for the beta-turn subset of 110 tetrapeptides and non-beta-turn subset of 30,231 tetrapeptides were 69.1 and 97.3%, respectively. The results obtained from this study support the conclusion that the residue-coupled effect along a tetrapeptide is important for the formation of a beta-turn.

  2. A simple radioactivity assay for measurement of methionine adenosyltransferase activity by aqueous chromatography

    International Nuclear Information System (INIS)

    Oeztuerk, M.; Lemonnier, F.; Cresteil, D.; Lemonnier, A.

    1983-01-01

    Methionine adenosyltransferase (ATP:L-methionine S-adenosyltransferase, EC 2.5.1.6) catalyzes the formation of S-adenosyl-L-methionine from ATP and L-methionine. Methionine metabolism is very important in human pathology. Methionine adenosyltransferase deficiency has recently been shown to be a specific enzymatic defect, whereas certain other diseases have only been associated with non-specific deficiencies of methionine adenosyltransferase. These different reasons explain the existence of numerous reports concerning the determination of hepatic methionine adenosyltransferase and of its isozymic forms, found in different tissues in man and rat. On the basis of the work of Chou and Lombardini, the authors report a rapid, sensitive technique using aqueous chromatography with phosphocellulose ion exchange paper to separate the S-adenosyl L-[methyl- 14 C]methionine from L-[methyl- 14 C]methionine. (Auth.)

  3. Integral enthalpy of mixing of the liquid ternary Au-Cu-Sn system

    International Nuclear Information System (INIS)

    Knott, S.; Li, Z.; Mikula, A.

    2008-01-01

    The integral enthalpy of mixing of the ternary Au-Cu-Sn has been determined with a Calvet type calorimeter at 6 different cross sections at 1273 K. The substitutional solution model of Redlich-Kister-Muggianu was used for a least square fit of the experimental data in order to get an analytical expression for the integral enthalpy of mixing. The ternary extrapolation models of Kohler, Muggianu and Toop were used to calculate the integral enthalpy of mixing and to compare measured and extrapolated values. Additional calculations of the integral enthalpy of mixing using the Chou model have been performed. With the calculated data, the iso-enthalpy lines have been determined using the Redlich-Kister-Muggianu model. A comparison of the data has been made

  4. Les territoires perdus de l'arabisme : Un siècle d'irrédentisme arabe

    OpenAIRE

    Gonzalez-Quijano , Yves

    2016-01-01

    International audience; Alors que les guerres et les contre-révolutions ravagent la région, que reste-t-il du "monde arabe" ? La question des frontières héritées des accords Sykes-Picot a été un enjeu central dans la définition d'un projet unitaire pour la région. A l'image du destin du premier Etat arabe moderne, "l'idée arabe" non seulement a échoué à se doter d'un territoire, mais a vu, de surcroît, tomber l'une après l'autre nombre de ses capitales les plus prestigieuses tandis que certai...

  5. Managing fatigue in patients with Parkinson's disease: a patient-focused perspective

    Directory of Open Access Journals (Sweden)

    Ridder A

    2016-07-01

    Full Text Available Andrew Ridder,1 Kelvin L Chou,1,2 1Department of Neurology, 2Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA Abstract: Fatigue, experienced as a significantly diminished energy level or an increased perception of effort disproportionate to attempted activities or general activity level, is being increasingly recognized as a common and disabling problem in patients with Parkinson’s disease. There are no commonly accepted criteria to diagnose fatigue in Parkinson’s disease and there is limited evidence regarding treatment of this symptom. This article reviews the current knowledge surrounding fatigue in Parkinson’s disease, including symptoms, epidemiology, diagnosis, and treatment, with a focus on the patient’s perspective. Keywords: Parkinson’s disease, fatigue, diagnosis, treatment

  6. An efficient method for computing the absorption of solar radiation by water vapor

    Science.gov (United States)

    Chou, M.-D.; Arking, A.

    1981-01-01

    Chou and Arking (1980) have developed a fast but accurate method for computing the IR cooling rate due to water vapor. Using a similar approach, the considered investigation develops a method for computing the heating rates due to the absorption of solar radiation by water vapor in the wavelength range from 4 to 8.3 micrometers. The validity of the method is verified by comparison with line-by-line calculations. An outline is provided of an efficient method for transmittance and flux computations based upon actual line parameters. High speed is achieved by employing a one-parameter scaling approximation to convert an inhomogeneous path into an equivalent homogeneous path at suitably chosen reference conditions.

  7. Réinventer la géodiversité

    Directory of Open Access Journals (Sweden)

    Denise Pumain

    1999-12-01

    Full Text Available L'année 1999 s'achève. Dans le passage des chiffres neuf aux chiffres ronds, il n'entre guère semble-t-il de frayeur millénariste, bogues informatiques exceptés ! Espérons que cette nouvelle ligne de changement de date nous épargnera, davantage que les malheureux passagers du navire échoué sur l'île du jour d'avant chez Umberto Eco. L'année écoulée laisse aux rivages de janvier une écume géographique de faits éclectiques, sur fond de mise en réseau - mise au pas planétaire, tant furent portée...

  8. Report of the transition crossing mini-workshop

    International Nuclear Information System (INIS)

    Martin, P.; Chou, W.

    1996-07-01

    This was the first in a series of mini-workshops on high intensity, high brightness hadron beams. Twenty five people from CERN, KEK, BNL, Fermilab and University of Houston attended the workshop. The first day was a plenary session with nine presentations. On the second day, three working groups (WG) were formed: WG-I was on theory, simulation and measurements, led by J.P. Riunaud (CERN) and P.L. Colestock (Fermilab); WG-II was on γ t -jump systems, led by T. Roser (BNL) and W. Chou (Fermilab); WG-III was on new schemes, led by Y. Mori (KEK) and J. Griffin (Fermilab). Each group gave a presentation at the final plenary session. The summaries from the three working groups are included in this report. During the workshop, P. Martin gave a guided tour to the Main Injector tunnel, which is under construction at Fermilab

  9. New results for antiproton-proton elastic scattering and various theoretical models

    International Nuclear Information System (INIS)

    Fazal-e-Aleem; Saleem, M.; Yodh, G.B.

    1991-01-01

    The most recent measurements of the ratio ρ of the real and imaginary parts of the forward-scattering amplitudes at 0.546 TeV, the total and elastic differential cross sections at 0.546 and 1.8 TeV for proton-antiproton scattering, are compared to the predictions of the generalized Chou-Yang and other theoretical models. For 1.8 TeV, the presence or absence of the break near -t∼0.15 (GeV/c) 2 and of the dip in the vicinity of 0.6 (GeV/c) 2 are also discussed in the light of various predictions. The possibility of a further rise of the ratio ρ at 1.8 TeV is also probed

  10. Atmospheric solar heating rate in the water vapor bands

    Science.gov (United States)

    Chou, Ming-Dah

    1986-01-01

    The total absorption of solar radiation by water vapor in clear atmospheres is parameterized as a simple function of the scaled water vapor amount. For applications to cloudy and hazy atmospheres, the flux-weighted k-distribution functions are computed for individual absorption bands and for the total near-infrared region. The parameterization is based upon monochromatic calculations and follows essentially the scaling approximation of Chou and Arking, but the effect of temperature variation with height is taken into account in order to enhance the accuracy. Furthermore, the spectral range is extended to cover the two weak bands centered at 0.72 and 0.82 micron. Comparisons with monochromatic calculations show that the atmospheric heating rate and the surface radiation can be accurately computed from the parameterization. Comparisons are also made with other parameterizations. It is found that the absorption of solar radiation can be computed reasonably well using the Goody band model and the Curtis-Godson approximation.

  11. Cryptanalysis and improvement of a quantum communication-based online shopping mechanism

    Science.gov (United States)

    Huang, Wei; Yang, Ying-Hui; Jia, Heng-Yue

    2015-06-01

    Recently, Chou et al. (Electron Commer Res 14:349-367, 2014) presented a novel controlled quantum secure direct communication protocol which can be used for online shopping. The authors claimed that their protocol was immune to the attacks from both external eavesdropper and internal betrayer. However, we find that this protocol is vulnerable to the attack from internal betrayer. In this paper, we analyze the security of this protocol to show that the controller in this protocol is able to eavesdrop the secret information of the sender (i.e., the customer's shopping information), which indicates that it cannot be used for secure online shopping as the authors expected. Accordingly, an improvement of this protocol, which could resist the controller's attack, is proposed. In addition, we present another protocol which is more appropriate for online shopping. Finally, a discussion about the difference in detail of the quantum secure direct communication process between regular quantum communications and online shopping is given.

  12. The Orang Suku Laut of Riau, Indonesia

    DEFF Research Database (Denmark)

    Chou, Cynthia Gek Hua

    and resources that have resulted in great demand on sea and land spaces. In this momentum of change, several aspects of rural culture including indigenous populations, like the Orang Suku Laut (people of the sea) of Riau have been deemed by the state architects of development programmes to hinder progress......Land reform has been an indisputable part of Indonesian revolution. The consequent execution of development programmes for nation-building have provoked intense hostility over territorial rights. Global market forces in Indonesia have seen increasing flows of transnational investments, technology...... the social assimilation of indigenous peoples as citizens, religious conversion and cultural identity. Cynthia Chou discusses how Indonesian nation-building development programmes have generated intense struggles over issues pertaining to territorial rights, social assimilation of indigenous peoples...

  13. Bringing holistic treatments to the attention of medicine: acupuncture as an effective poststroke rehabilitation tool.

    Science.gov (United States)

    Farmer, Cecilia

    2015-04-01

    This article reviews 3 studies that explore the effects of acupuncture on poststroke patients suffering from chronic stroke symptoms. The 3 studies selected strive to show how acupuncture can be a safe, noninvasive, and cost-effect rehabilitation tool useful in adjunct with traditional rehabilitation. Chou et al (2009), Hopwood et al (2008), and Wayne et al (2005) all studied acupuncture's effects on quality of life. Additionally, both Hopwood et al and Wayne et al studied acupuncture's effects on mobility and activities of daily living. While the frequency, duration, and length of the entire treatment varied by study, overall, the results of all 3 studies suggest that acupuncture increases quality of life and improves mobility and activities of daily living. © The Author(s) 2014.

  14. The approach of panti p and pp elastic scattering to 'asymptopia'

    International Nuclear Information System (INIS)

    Block, M.M.; Cahn, R.N.

    1984-01-01

    We have previously made a model-free analysis of the t=0 amplitude for panti p and pp elastic scattering using data in the energy region 5 2 [log(dsigmasub(n)/dt)]/dt 2 at t=0, is a sensitive indicator of this transition to 'asymptopia', being positive at ISR energies, going through zero near √s=2TeV (the tevatron collider), and becoming very negative at √s=40 TeV (the SSC), where the predictions for the Chou-Yang model are hardly distinguishable from those for a sharp disk, after the diffraction have been filled in by the contribution of the real part. (orig.)

  15. A computer graphics program system for protein structure representation.

    Science.gov (United States)

    Ross, A M; Golub, E E

    1988-01-01

    We have developed a computer graphics program system for the schematic representation of several protein secondary structure analysis algorithms. The programs calculate the probability of occurrence of alpha-helix, beta-sheet and beta-turns by the method of Chou and Fasman and assign unique predicted structure to each residue using a novel conflict resolution algorithm based on maximum likelihood. A detailed structure map containing secondary structure, hydrophobicity, sequence identity, sequence numbering and the location of putative N-linked glycosylation sites is then produced. In addition, helical wheel diagrams and hydrophobic moment calculations can be performed to further analyze the properties of selected regions of the sequence. As they require only structure specification as input, the graphics programs can easily be adapted for use with other secondary structure prediction schemes. The use of these programs to analyze protein structure-function relationships is described and evaluated. PMID:2832829

  16. Screening among workers in a dockyard in the city of Varna

    Directory of Open Access Journals (Sweden)

    M. Milkov

    2011-03-01

    Full Text Available Hearing reduction and hearing loss are common among the industrial workers exposed to continuous and intensive occupational noise, although they are completely preventable. Hearing protection devices are more and more widely used in modern industry, however, they are not efficient enough. That is why preventive otorhinolaryngologic examinations should regularly been performed to enable the early diagnosis and timely treatment of this severe pathology. Several recent investigations deal with the damage of the medium and inner ear as well as of the hearing characteristics caused by intensive and longlasting industrial noise, especially in construction in the USA (Wu, et al., 1998; Edelson, et al., 2009, in dockyards (Sliwinska-Kowalska, et al., 2004; Zamyslowska-Szmytke, et al., 2007, in a liquefied petroleum gas cylinder infusion factory in Taiwan (Chang, et al., 2009, in a semiconductor factory (Chou, et al., 2009, in steel mills, lumber mills and marble shops in Brazil (Boger, et al., 2009, among truck drivers (Krishnamurti, 2009; Karimi, et al., 2010, etc. The combined harmful effects of workplace noise and various agents such as chemicals (Morata, et al., 1993; Sliwinska-Kowalska, et al., 2004; Sliwinska- Kowalska, et al., 2005 and heat (Singh, et al., 2010 are intensively studied, too. Binaurial hearing impairment caused by simultaneous exposure to occupational noise and cigarette smoke is proved, too (Mohammadi, et al., 2010. The role of shift-work on noise-induced hearing loss is emphasized (Borchgrevink, 2009; Chou, et al., 2009. The purpose of the present paper is to analyze the dynamics of hearing reduction of dockyard workers by twofold comprehensive screening examinations as a first step in a broad prevention programme.

  17. Statistically significant dependence of the Xaa-Pro peptide bond conformation on secondary structure and amino acid sequence

    Directory of Open Access Journals (Sweden)

    Leitner Dietmar

    2005-04-01

    Full Text Available Abstract Background A reliable prediction of the Xaa-Pro peptide bond conformation would be a useful tool for many protein structure calculation methods. We have analyzed the Protein Data Bank and show that the combined use of sequential and structural information has a predictive value for the assessment of the cis versus trans peptide bond conformation of Xaa-Pro within proteins. For the analysis of the data sets different statistical methods such as the calculation of the Chou-Fasman parameters and occurrence matrices were used. Furthermore we analyzed the relationship between the relative solvent accessibility and the relative occurrence of prolines in the cis and in the trans conformation. Results One of the main results of the statistical investigations is the ranking of the secondary structure and sequence information with respect to the prediction of the Xaa-Pro peptide bond conformation. We observed a significant impact of secondary structure information on the occurrence of the Xaa-Pro peptide bond conformation, while the sequence information of amino acids neighboring proline is of little predictive value for the conformation of this bond. Conclusion In this work, we present an extensive analysis of the occurrence of the cis and trans proline conformation in proteins. Based on the data set, we derived patterns and rules for a possible prediction of the proline conformation. Upon adoption of the Chou-Fasman parameters, we are able to derive statistically relevant correlations between the secondary structure of amino acid fragments and the Xaa-Pro peptide bond conformation.

  18. Guidelines warfare over interventional techniques: is there a lack of discourse or straw man?

    Science.gov (United States)

    Manchikanti, Laxmaiah; Benyamin, Ramsin M; Falco, Frank J E; Caraway, David L; Datta, Sukdeb; Hirsch, Joshua A

    2012-01-01

    Guideline development seems to have lost some of its grounding as a medical science. At their best, guidelines should be a constructive response to assist practicing physicians in applying the exponentially expanding body of medical knowledge. In fact, guideline development seems to be evolving into a cottage industry with multiple, frequently discordant guidance on the same subject. Evidence Based Medicine does not always provide for conclusive opinions. With competing interests of payers, practitioners, health policy makers, and third parties benefiting from development of the guidelines as cost saving measures, guideline preparation has been described as based on pre-possession, vagary, rationalization, or congeniality of conclusion. Beyond legitimate differences in opinions regarding the evidence that could yield different guidelines there are potentials for conflicts of interest and various other issues play a major role in guideline development. As is always the case, conflicts of interest in guideline preparation must be evaluated and considered. Following the development of American Pain Society (APS) guidelines there has been an uproar in interventional pain management communities on various issues related to not only the evidence synthesis, but conflicts of interest. A recent manuscript published by Chou et al, in addition to previous publications, appears to have limited clinician involvement in the development of APS guidelines, and demonstrates some of these challenges clearly. This manuscript illustrates the deficiencies of Chou et al's criticisms, and demonstrates their significant conflicts of interest, and use a lack of appropriate evaluations in interventional pain management as a straw man to support their argument. Further, this review will attempt to demonstrate that excessive focus on this straw man has inhibited critique of what we believe to be flaws in the approach.  

  19. Effect of rehabilitation on a patient suffering from a tuberculous brain abscess with Gerstmann's syndrome: case report

    Directory of Open Access Journals (Sweden)

    Kuo CL

    2012-05-01

    Full Text Available Chih-Lan Kuo1, Sui-Foon Lo1,2, Chun-Lin Liu3, Chia-Hui Chou4, Li-Wei Chou1,2,5¹Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; ²School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 3Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan; 4Department of Infectious disease, China Medical University Hospital, Taichung, Taiwan; 5Department of Physical Therapy, China Medical University, Taichung, TaiwanAbstract: There are few reports in the literature of tuberculous brain abscess. Tuberculous brain abscess usually occurs in an immunocompromised host. Almost all previously documented cases have involved acquired immune deficiency syndrome. We encountered a 53-year-old right-handed immunocompetent male who was initially suspected of having a cerebrovascular accident due to acute-onset right hemiparesis and paresthesia. A tentative diagnosis of brain tumor versus brain abscess was made on imaging studies. The patient was finally diagnosed with a tuberculous brain abscess based upon deterioration on imaging and a positive tuberculosis culture. The tuberculous brain abscess was located in the left parietal lobe, which resulted in Gerstmann's syndrome and right-sided apraxia. Stereotactic surgery was performed. He was also given antituberculosis chemotherapy and comprehensive rehabilitation. Considerable improvement was noted after rehabilitation. The patient even returned to a normal life and work. Our case demonstrates that an aggressive intensive inpatient rehabilitation program combined with stereotactic surgery and effective antituberculosis therapy play an important role in improving the outcome for patients with tuberculous brain abscess, Gerstmann's syndrome, and right-sided apraxia.Keywords: tuberculous brain abscess, Gerstmann's syndrome, rehabilitation

  20. Water Vapor Transport Over the Tropical Oceans During ENSO as Diagnosed from TRMM and SSM/I Data

    Science.gov (United States)

    Robertson, Franklin R.; Smith, Eric A.; Sohn, Byung-Ju

    2000-01-01

    Traditionally, large-scale water vapor transport [div Q] has been derived directly from circulation statistics in which transport processes are often depicted by mean and eddy motions. Thus detailed and accurate calculations of moisture transport terms over the globe are required. Notably, the lack of systematically spaced conventional measurements of meteorological variables over oceans has hindered understanding of the distribution and transport of water vapor. This motivates the use of indirect calculation methods in which horizontal divergence of water vapor is balanced by the evaporation minus precipitation, assuming the rate of changes of precipitable water and condensates is small over a sufficiently long time period. In order to obtain the water vapor transport, we need evaporation rate minus precipitation (E-P). Focussing on the differences in water vapor transport between El Nino and La Nina periods and their influences on atmospheric circulations, we study January, February, and March of 1998 and 1999 periods which represent El Nino and La Nina respectively. SSM/I-derived precipitation and evaporation rate from SSM/I wind and total precipitable water, in conjunction with NCEP SST and surface air temperature, are used for the calculation of the transport potential function. For the retrieval of evaporation we use a stability-dependent aerodynamic bulk scheme developed by Chou (1993). It was tested against aircraft covariance fluxes measured during cold air outbreaks over the North Atlantic Ocean. Chou et al. (1997) reported that the SSM/I retrieved latent heat flux over the western Pacific warm pool area were found to be comparable with daily mean fluxes of a ship measurements during TOGA/COARE.

  1. Revision of the Agathidinae (Hymenoptera, Braconidae) of Vietnam, with the description of forty-two new species and three new genera

    Science.gov (United States)

    van Achterberg, Cornelis; Long, Khuat Dang

    2010-01-01

    Abstract The species of seventeen genera of Agathidinae (Braconidae) from Vietnam are revised: Agathis Latreille, 1804, Bassus Fabricius, 1804; Biroia Szépligeti, 1900; Braunsia Kriechbaumer, 1894; Camptothlipsis Enderlein, 1920; Coccygidium de Saussure, 1892; Coronagathis gen. n. (type species: Coronagathis cornifera sp. n.); Cremnops Foerster, 1862; Disophrys Foerster, 1862; Earinus Wesmael, 1837; Euagathis Szépligeti, 1900; Gyragathis gen. n. (type species: Gyragathis quyi sp. n.), Gyrochus Enderlein, 1920; Lytopylus Foerster, 1862; Therophilus Wesmael, 1837; Troticus Brullé, 1846, and Zelodia gen. n. (type species: Zelomorpha varipes van Achterberg & Maetô, 1990). Keys to the Vietnamese species are given. Sixty-five species are recognised, of which twelve species are newly recorded for Vietnam: Bassus albifasciatus (Watanabe, 1934), Coccygidium angostura (Bhat & Gupta, 1977), Cremnops atricornis (Smith, 1874), stat. n., Disophrys erythrocephala Cameron, 1900, Gyrochus yunnanensis Wang, 1984, Lytopylus romani (Shestakov, 1940), comb. n., Therophilus festivus (Muesebeck, 1953), comb. n., Therophilus javanus (Bhat & Gupta, 1977), comb. n., Therophilus lienhuachihensis (Chou & Sharkey, 1989), comb. n., Therophilus marshi (Bhat & Gupta, 1977), comb. n., Zelodia absoluta (Chen & Yang, 1998), comb. n. and Zelodia longidorsata (Bhat & Gupta, 1977), comb. n. Forty-two species are new to science: Agathis citrinisoma sp. n., Bassus albobasalis sp. n., Bassus albozonatus sp. n., Biroia soror sp. n., Braunsia bicolorata sp. n., Braunsia devriesi sp. n., Braunsia maculifera sp. n., Braunsia nigrapiculata sp. n., Braunsia pumatica sp. n., Camptothlipsis hanoiensis sp. n., Coronagathis cornifera sp. n., Earinus aurantius sp. n., Earinus brevistigmus sp. n., Euagathis flavosoma sp. n., Disophrys maculifera sp. n., Disophrys quymanhi sp. n., Disophrys rhinoides sp. n., Gyragathis quyi sp. n., Therophilus annuliferus sp. n., Therophilus cattienensis sp. n., Therophilus

  2. No gynecologist in town: the gynecological care of women in rural Taiwan

    Directory of Open Access Journals (Sweden)

    Lai LJ

    2015-07-01

    Full Text Available Li-Jung Lai,1 Chia-Lin Chou,2 H Irene Su,3 Tzeng-Ji Chen,1,4 Li-Fang Chou,5 Yueh-Ching Chou,2,6,7 Shinn-Jang Hwang,1,8 Hann-Chin Yu9,10 1Department of Family Medicine, 2Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan; 3Department of Reproductive Medicine, University of California, San Diego, CA, USA; 4Institute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, 5Department of Public Finance, National Chengchi University, 6Department and Institute of Pharmacology, National Yang-Ming University, 7College of Pharmacy, Taipei Medical University, 8Department of Family Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 9Taipei Veterans General Hospital Hsinchu Branch, Hsinchu County, Taiwan; 10Department of Healthcare Management, Yuanpei University, Hsinchu, Taiwan Background: A shortage of gynecologists exists in many countries. Even within an affluent country, gynecological clinics might not be evenly distributed. The purpose of the study was to investigate the disparity in gynecological care between adult women living in towns with and without gynecologists in Taiwan.Methods: Data sources were the cohort datasets of the National Health Insurance Research Database, with claims data of 1 million beneficiaries in 2010. A woman’s residency was operationally inferred from the locations where she had most frequently visited physicians’ clinics or local community hospitals within the year.Results: In Taiwan, 145 (39.4% of 368 towns had no practicing gynecologist. Of 382,167 women with health care use in the datasets, 21,794 (5.7% lived in towns without a gynecologist. The overwhelming majority of these towns lay in sparsely populated, rural areas. During the year, 132,702 women (34.7% had sought medical help for gynecological diseases and 113,698 (29.8% had visited gynecologists for gynecological diseases. Women in towns without a gynecologist were less

  3. Effects of electroacupuncture on recent stroke inpatients with incomplete bladder emptying: a preliminary study

    Directory of Open Access Journals (Sweden)

    Yu KW

    2012-11-01

    Full Text Available Kuo-Wei Yu,1,* Chien-Lin Lin,1,2 Chun-Chuang Hung,3 Eric Chieh-Lung Chou,4 Yueh-Ling Hsieh,5 Te-Mao Li,2,3,* Li-Wei Chou1,2,61Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 2School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 3Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan; 4Department of Urology, China Medical University Hospital, Taichung, Taiwan; 5Department of Physical Therapy, China Medical University, Taichung, Taiwan; 6Acupuncture Research Center, China Medical University, Taichung, Taiwan*These authors contributed equally to this workBackground: Incomplete bladder emptying (IBE is defined as having a postvoid residual (PVR urine volume greater than 100 mL for 2 consecutive days. IBE is common in stroke patients and could necessitate indwelling or intermittent catheterization. The condition is correlated with urinary tract infections, which could impede rehabilitation progress and increase medical costs. Treatment for patients with IBE includes bladder retraining, biofeedback, medication, and botulinum toxin injection, but none of these interventions are completely effective.Methods: All patients with acute stroke who were admitted to the rehabilitation ward between August 2010 and April 2011 were included in the study and their PVR urine volume was checked. Electroacupuncture (EA; 1 Hz, 15 minutes was performed on the acupoints Sanyinjiao (SP6, Ciliao (BL32, and Pangguangshu (BL28 of stroke patients with IBE for a total of ten treatments (five times a week for 2 weeks. Bladder diaries, which included the spontaneous voiding and PVR urine volumes, were recorded during the course of treatment.Results: The presence of IBE was not related to sex, history of diabetes mellitus, stroke type (hemorrhagic or ischemic, or stroke location (P > 0.05. Among the 49 patients in the study, nine (18% had IBE

  4. The Leipzig Ice Nucleation chamber Comparison (LINC): An overview of ice nucleation measurements observed with four on-line ice nucleation devices

    Science.gov (United States)

    Kohn, Monika; Wex, Heike; Grawe, Sarah; Hartmann, Susan; Hellner, Lisa; Herenz, Paul; Welti, André; Stratmann, Frank; Lohmann, Ulrike; Kanji, Zamin A.

    2016-04-01

    Mixed-phase clouds (MPCs) are found to be the most relevant cloud type leading to precipitation in mid-latitudes. The formation of ice crystals in MPCs is not completely understood. To estimate the effect of aerosol particles on the radiative properties of clouds and to describe ice nucleation in models, the specific properties of aerosol particles acting as ice nucleating particles (INPs) still need to be identified. A number of devices are able to measure INPs in the lab and in the field. However, methods can be very different and need to be tested under controlled conditions with respect to aerosol generation and properties in order to standardize measurement and data analysis approaches for subsequent ambient measurements. Here, we present an overview of the LINC campaign hosted at TROPOS in September 2015. We compare four ice nucleation devices: PINC (Portable Ice Nucleation Chamber, Chou et al., 2011) and SPIN (SPectrometer for Ice Nuclei) are operated in deposition nucleation and condensation freezing mode. LACIS (Leipzig Aerosol Cloud Interaction Simulator, Hartmann et al., 2011) and PIMCA (Portable Immersion Mode Cooling chamber) measure in the immersion freezing mode. PIMCA is used as a vertical extension to PINC and allows activation and droplet growth prior to exposure to the investigated ice nucleation temperature. Size-resolved measurements of multiple aerosol types were performed including pure mineral dust (K-feldspar, kaolinite) and biological particles (Birch pollen washing waters) as well as some of them after treatment with sulfuric or nitric acid prior to experiments. LACIS and PIMCA-PINC operated in the immersion freezing mode showed very good agreement in the measured frozen fraction (FF). For the comparison between PINC and SPIN, which were scanning relative humidity from below to above water vapor saturation, an agreement was found for the obtained INP concentration. However, some differences were observed, which may result from ice

  5. Borehole data package for wells 299-W22-48, 299-W22-49, and 299-W22-50 at single-shell tank waste management Area S-SX

    International Nuclear Information System (INIS)

    Horton, D.G.; Johnson, V.G.

    2000-01-01

    Three new Resource Conservation and Recovery Act (RCRA) groundwater monitoring wells were installed at the single-shell tank farm Waste Management Area (WMA) S-SX in October 1999 through February 2000 in fulfillment of Tri-Party Agreement (Ecology 1996) milestone M-24-41. The wells are 299-W22-48, 299-W22-49, and 299-W22-50. Well 299-W22-48 is located east of the southeast corner of 241-S tank farm and is a new downgradient well in the monitoring network. Well 299-W22-49 is located on the east side of the 241-SX tank farm, adjacent to well 299-W22-39, which it replaces in the monitoring network. Well 299-W22-50 is located at the southeast corner of the 241-SX tank farm and is a replacement for downgradient monitoring well 299-W22-46, which is going dry. The original assessment monitoring plan for WMA S-SX was issued in 1996 (Caggiano 1996). That plan was updated for the continued assessment at WMA S-SX in 1999 (Johnson and Chou 1999). The updated plan provides justification for the new wells. The new wells were constructed to the specifications and requirements described in Washington Administrative Code (WAC) 173-160 and WAC 173-303, the updated assessment plan for WMA S-SX (Johnson and Chou 1999), and the description of work for well drilling and construction. This document compiles information on the drilling and construction, well development, pump installation, and sediment and groundwater sampling applicable to the installation of wells 299-W22-48, 299-W22-49 and 299-W22-50. Appendix A contains the Well Summary Sheets (as-built diagrams), the Well Construction Summary Reports, and the geologist's logs. Appendix B contains results of laboratory analyses of the physical properties of sediment samples obtained during drilling. Appendix C contains borehole geophysical logs, and Appendix D contains the analytical results from groundwater samples obtained during well drilling and construction

  6. A PRELIMINARY ANNOTATED CHECKLIST OF THE PAPILIONIDAE OF LAOS WITH NOTES ON TAXONOMY, PHENOLOGY, DISTRIBUTION AND VARIATION (Lepidoptera, Papilionoidea

    Directory of Open Access Journals (Sweden)

    A.M. Cotton

    2006-10-01

    Full Text Available 63 Papilionid taxa of Laos are reported representing 60 biological species. Of these, the occurrence of Papilio elephenor is unproven, and that of Papilio krishna is refuted, leaving 58 species confirmed for Laos. Notes on their taxonomy, distribution, phenology and variation are given. The following synonymies or changes of status are herewith listed:Graphium antiphates itamputi is regarded as a separate subspecies from pompilius stat. rev.Papilio tamerlanus timur Ney, 1911 is a synonym of Papilio alebion mullah Alphéraky, 1897, syn. nov. The following combinations are therefore proposed for the collective species: Graphium mullah mullah (Alphéraky, 1897 comb. nov. applies to the Sichuan population; Graphium mullah chungianus (Murayama, 1961 comb. nov., for the Taiwanese subspecies; and Graphium mullah kooichii (Morita, 1996 comb. nov. for the Lao subspecies.The true type of Papilio arycles sphinx Fruhstorfer, 1899 is identified, and arycleoides Fruhstorfer, 1902 placed in synonymy, syn. nov.Teinopalpus imperialis bhumipoli Nakano & Sukkit, 1985, T. i. gerritesi Nakano, 1995, T. i. gillesi Turlin, 1991, and T. i. hakkaorum Schäffler 2004 are shown to be synonyms of Teinopalpus imperialis imperatrix de Nicéville, 1899, syn. nov.Atrophaneura varuna liziensis Zhao, 1997 is synonymized with A. varuna astorion (Westwood, 1842 syn. nov.The names elegans Chou et al., 2000, pulcher Chou et al., 2000 and longimacula Wang & Niu, 2002 are sunk as synonyms of Papilio bianor bianor syn. nov.Papilio bianor significans Fruhstorfer, 1902 is regarded as a valid subspecies (stat. rev. and the ranges of Papilio bianor gladiator Fruhstorfer, [1902] and ganesa Doubleday, 1842 are clarified.Papilio noblei de Nicéville, [1889] is shown to be monotypic, and haynei Tytler, 1926 is sunk as a synonym syn. nov.Papilio hipponous siamensis Godfrey, 1916 is synonymized with pitmani Elwes & de Nicéville, [1887] syn. nov.The taxon imitata Monastyrskii & Devyatkin, 2003

  7. Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

    Directory of Open Access Journals (Sweden)

    Chou PS

    2017-03-01

    Full Text Available Ping-Song Chou,1 Chiou-Lian Lai,1–3 Yii-Her Chou,4,5,* Wei-Pin Chang6,* 1Department of Neurology, Kaohsiung Medical University Hospital, 2Department of Neurology, Faculty of Medicine, College of Medicine, 3Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, 4Department of Urology, Faculty of Medicine, College of Medicine, 5Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 6School of Health Care Administration, Taipei Medical University, Taipei City, Taiwan *These authors contributed equally to this work Purpose: Sleep apnea (SA-induced chronic intermittent hypoxia increases oxidative stress and inflammation, which may contribute to the pathophysiology of Parkinson’s disease (PD. This study evaluated the risk of PD following SA diagnosis.Patients and methods: This was a 3-year nationwide population-based matched cohort study using claims data from the National Health Insurance Research Database (NHIRD, Taiwan. We analyzed 1,944 patients diagnosed as having SA between 1997 and 2005 and a matched cohort of 9,720 non-SA patients from the NHIRD. Patients with a history of PD were excluded. Each patient was followed up for 3 years to evaluate subsequent PD development.Results: Of the 11,664 patients, 17 (0.9% and 38 (0.4% from the SA and matched non-SA cohorts, respectively, were subsequently diagnosed as having PD during follow-up. After adjustments for potential confounders, the SA cohort had a 1.85-fold higher risk of PD than the non-SA cohort (95% confidence interval [CI] =1.02–3.35; P=0.042. After age and sex stratification, PD development was independently associated with SA only in men (adjusted hazard ratio [HR], 2.26; 95% CI =1.11–4.63; P<0.05 and in patients aged ≥60 years (adjusted HR, 1.93; 95% CI =1.01–3.71; P<0.05.Conclusion: Our study suggests that patients with SA are at an increased longitudinal risk of PD. Furthermore, age and male sex are independently

  8. Miscanthus plants used as an alternative biofuel material. The basic studies on ecology and molecular evolution

    Energy Technology Data Exchange (ETDEWEB)

    Chou, Chang-Hung [Graduate Institute of Ecology and Evolutionary Biology, College of Life Sciences, China Medical University, Taichung 404 (China)

    2009-08-15

    Miscanthus Anderss, widely distributed in Asia and Pacific Islands, possesses 20 species. Of which 8 species and 1 variety were recorded in Chinese Mainland; 6 species and 1 variety found in Japan; 5 species and 3 varieties distributed in Taiwan; 3 species documented in the Philippines; and rest of species have been recorded in Jawa, eastern Himalaya, and Sikkim. The plant is a C{sub 4} perennial grass with high productivity of biomass. In the 19th and early 20th centuries in Taiwan, Miscanthus was a very important crop used for forage grass, clothing, and shelter, etc. The relatively high germination, and high yield of biomass made the plant available for people of Taiwan including aboriginal. The taxonomic study of Miscanthus plants was much done by several scientists, and its ecological study has been only taken by the present author since 1972. Chou and his associates paid a great attention to elucidate the mechanism of dominance of Miscanthus vegetation and found that allelopathy plays an important role. In addition, the population biology of Miscanthus taxa by using polyacrylamide gel electrophoreses technique to examine the patterns of peroxidase and esterase among populations (over 100) of Miscanthus in Taiwan were conducted. They also elucidated the phylogenetic relationship among species and varieties in Taiwan. Chou and Ueng proposed an evolutionary trend of Miscanthus species, indicating that the Miscanthus sinensis was assumed to be the origin of Miscanthus Anderss, which evolved to M. sinensis var. formosana, and M. sinensis var. flavidus, and M. sinensis var. transmorrisonensis, and Miscanthus floridulus was thought to be an out group of M. sinensis complex. Moreover, molecular phylogeny was attempted to clarify the population heterogeneity of M. sinensis complex, resulting in a substantial information. It would be available for making hybridization between Miscanthus species and its related species, such as Saccharum (sugar cane) spp. which is a

  9. Borehole data package for wells 299-W22-48, 299-W22-49, and 299-W22-50 at single-shell tank waste management Area S-SX

    Energy Technology Data Exchange (ETDEWEB)

    DG Horton; VG Johnson

    2000-05-18

    Three new Resource Conservation and Recovery Act (RCRA) groundwater monitoring wells were installed at the single-shell tank farm Waste Management Area (WMA) S-SX in October 1999 through February 2000 in fulfillment of Tri-Party Agreement (Ecology 1996) milestone M-24-41. The wells are 299-W22-48, 299-W22-49, and 299-W22-50. Well 299-W22-48 is located east of the southeast corner of 241-S tank farm and is a new downgradient well in the monitoring network. Well 299-W22-49 is located on the east side of the 241-SX tank farm, adjacent to well 299-W22-39, which it replaces in the monitoring network. Well 299-W22-50 is located at the southeast corner of the 241-SX tank farm and is a replacement for downgradient monitoring well 299-W22-46, which is going dry. The original assessment monitoring plan for WMA S-SX was issued in 1996 (Caggiano 1996). That plan was updated for the continued assessment at WMA S-SX in 1999 (Johnson and Chou 1999). The updated plan provides justification for the new wells. The new wells were constructed to the specifications and requirements described in Washington Administrative Code (WAC) 173-160 and WAC 173-303, the updated assessment plan for WMA S-SX (Johnson and Chou 1999), and the description of work for well drilling and construction. This document compiles information on the drilling and construction, well development, pump installation, and sediment and groundwater sampling applicable to the installation of wells 299-W22-48, 299-W22-49 and 299-W22-50. Appendix A contains the Well Summary Sheets (as-built diagrams), the Well Construction Summary Reports, and the geologist's logs. Appendix B contains results of laboratory analyses of the physical properties of sediment samples obtained during drilling. Appendix C contains borehole geophysical logs, and Appendix D contains the analytical results from groundwater samples obtained during well drilling and construction.

  10. Impact picture and internal matter motion for elastic scattering

    International Nuclear Information System (INIS)

    Bourrely, C.; Soffer, J.; Wu, T.T.

    1978-01-01

    Since four-dimensional relativistic quantum field theories have all the desirable properties such as particle production, unitarity, and analyticity, they provide a useful way to gain theoretical knowledge not only for weak and electromagnetic processes but also for strong interactions. For the dynamics of strong interactions, because of the necessity of understanding all orders of perturbation theory, the simplest case is the high energy limit. After a brief review of the general features of elastic scattering in field theories, the need of developing a phenomenology in order to make contact with present and future experimental data is discussed. Such a phenomenology must satisfy the dual requirement of, on the one hand, giving an accurate description of hadronic experimental data at high energies and, on the other hand, having the s → infinity behavior obtained from field theories. Recent improvements on such a phenomenology are emphasized, and include better parametrization and proper Regge background and spin effects. In particular, the spin of the proton is taken into account by using the concept of hadronic matter current of Chou and Yang. In addition to the total and differential cross sections for ISABELLE energies, predictions are obtained for both polarization and R parameters for proton--proton elastic scattering. Sore theoretical problems for the future are outlined

  11. Nanoimprint lithography for microfluidics manufacturing

    Science.gov (United States)

    Kreindl, Gerald; Matthias, Thorsten

    2013-12-01

    The history of imprint technology as lithography method for pattern replication can be traced back to 1970's but the most significant progress has been made by the research group of S. Chou in the 1990's. Since then, it has become a popular technique with a rapidly growing interest from both research and industrial sides and a variety of new approaches have been proposed along the mainstream scientific advances. Nanoimprint lithography (NIL) is a novel method for the fabrication of micro/nanometer scale patterns with low cost, high throughput and high resolution. Unlike traditional optical lithographic approaches, which create pattern through the use of photons or electrons to modify the chemical and physical properties of the resist, NIL relies on direct mechanical deformation of the resist and can therefore achieve resolutions beyond the limitations set by light diffraction or beam scattering that are encountered in conventional lithographic techniques. The ability to fabricate structures from the micro- to the nanoscale with high precision in a wide variety of materials is of crucial importance to the advancement of micro- and nanotechnology and the biotech- sciences as a whole and will be discussed in this paper. Nanoimprinting can not only create resist patterns, as in lithography, but can also imprint functional device structures in various polymers, which can lead to a wide range of applications in electronics, photonics, data storage, and biotechnology.

  12. Essai sur le rôle d’une espèce végétale rustique pour un développement durable de la steppe algérienne

    Directory of Open Access Journals (Sweden)

    Benabdeli Khéloufi

    2006-07-01

    Full Text Available La steppe en Algérie est un espace stratégique en matière de lutte contre la désertification, il couvre plus de 20 millions d’hectares et connaît une dégradation importante. Différents programmes de protection et de réhabilitation de cet espace ont échoué et sont souvent à l’origine de l’aggravation de cette dégradation. Une synthèse sur les causes de cet échec permettront de proposer une nouvelle approche axée sur l’introduction d’une espèce végétale très rustique et dont l’impact écologique pourrait sauver la steppe.The steppe in Algeria is a strategic space as regards to the control of desertification, it covers more than 20 million hectares and knows an important degradation. Various programmes of protection and rehabilitation concerning this space failed and are at the origin of the aggravation of this degradation. A synthesis of the causes of this failure will make it possible to propose a new approach centered on the introduction of a very rustic plant species and whose ecological impact could save the steppe.

  13. Detection of unsuspected colonic abnormalities using the pneumocolon technique during small bowel meal examination

    International Nuclear Information System (INIS)

    Chou, S.; Skehan, S.J.; Brown, A.L.; Rawlinson, J.; Somers, S.

    2000-01-01

    AIMS: The pneumocolon technique in small bowel meal examination is used to obtain double-contrast views of the distal ileum. The purpose of this study was to determine the proportion of cases in which an overhead pneumocolon radiograph demonstrated clinically relevant findings in the colon. METHODS: The overhead pneumocolon radiographs in 151 patients who underwent small bowel meals were evaluated retrospectively. A chart review was performed on those patients with positive colonic findings to determine if the suspected abnormalities affected patient management. RESULTS: Colonic abnormalities were identified in 34 of the 151 patients. One patient had a previously undiagnosed ascending colonic cancer; 17 had evidence of acute or chronic colitis; 13 had diverticulosis; one had a caecal polyp; one had an ileosigmoid fistula; one had a filling defect in the ascending colon. In 25 cases the colonic abnormality was visible only on the pneumocolon radiograph and not on the preceding single-contrast images. Management was altered by the colonic findings in seven cases. False-positive findings occurred in two cases. CONCLUSIONS: A routine overhead radiograph following use of the pneumocolon technique is a useful adjunct to small bowel meal examination as it can yield unsuspected and clinically significant colonic findings. Chou, S. (2000)

  14. Complete heat transfer solutions of an insulated regular polygonal pipe by using a PWTR model

    International Nuclear Information System (INIS)

    Wong, K.-L.; Chou, H.-M.; Li, Y.-H.

    2004-01-01

    The heat transfer characteristics for insulated long regular polygonal (including circular) pipes are analyzed by using the same PWRT model in the present study as that used by Chou and Wong previously [Energy Convers. Manage. 44 (4) (2003) 629]. The thermal resistance of the inner convection term and the pipe conduction term in the heat transfer rate are not neglected in the present study. Thus, the complete heat transfer solution will be obtained. The present results can be applied more extensively to practical situations, such as heat exchangers. The results of the critical thickness t cr and the neutral thickness t e are independent of the values of J (generated by the combined effect of the inner convection term and the pipe conduction term). However, the heat transfer rates are dependent on the values of J. The present study shows that the thermal resistance of the inner convection term and the pipe conduction term cannot be neglected in the heat transfer equation in situations of low to medium inner convection coefficients h i and/or low to medium pipe conductivities K, especially in situations with large pipe sizes or/and great outer convection coefficients h 0

  15. Investigation into adamantane-based M2 inhibitors with FB-QSAR.

    Science.gov (United States)

    Wei, Hang; Wang, Cheng-Hua; Du, Qi-Shi; Meng, Jianzong; Chou, Kuo-Chen

    2009-07-01

    Because of their high resistance rate to the existing drugs, influenza A viruses have become a threat to human beings. It is known that the replication of influenza A viruses needs a pH-gated proton channel, the so-called M2 channel. Therefore, to develop effective drugs against influenza A, the most logic strategy is to inhibit the M2 channel. Recently, the atomic structure of the M2 channel was determined by NMR spectroscopy (Schnell, J.R. and Chou, J.J., Nature, 2008, 451, 591-595). The high-resolution NMR structure has provided a solid basis for structure-based drug design approaches. In this study, a benchmark dataset has been constructed that contains 34 newly-developed adamantane-based M2 inhibitors and covers considerable structural diversities and wide range of bioactivities. Based on these compounds, an in-depth analysis was performed with the newly developed fragment-based quantitative structure-activity relationship (FB-QSAR) algorithm. The results thus obtained provide useful insights for dealing with the drug-resistant problem and designing effective adamantane-based antiflu drugs.

  16. Fast method to compute scattering by a buried object under a randomly rough surface: PILE combined with FB-SA.

    Science.gov (United States)

    Bourlier, Christophe; Kubické, Gildas; Déchamps, Nicolas

    2008-04-01

    A fast, exact numerical method based on the method of moments (MM) is developed to calculate the scattering from an object below a randomly rough surface. Déchamps et al. [J. Opt. Soc. Am. A23, 359 (2006)] have recently developed the PILE (propagation-inside-layer expansion) method for a stack of two one-dimensional rough interfaces separating homogeneous media. From the inversion of the impedance matrix by block (in which two impedance matrices of each interface and two coupling matrices are involved), this method allows one to calculate separately and exactly the multiple-scattering contributions inside the layer in which the inverses of the impedance matrices of each interface are involved. Our purpose here is to apply this method for an object below a rough surface. In addition, to invert a matrix of large size, the forward-backward spectral acceleration (FB-SA) approach of complexity O(N) (N is the number of unknowns on the interface) proposed by Chou and Johnson [Radio Sci.33, 1277 (1998)] is applied. The new method, PILE combined with FB-SA, is tested on perfectly conducting circular and elliptic cylinders located below a dielectric rough interface obeying a Gaussian process with Gaussian and exponential height autocorrelation functions.

  17. Accurate prediction of subcellular location of apoptosis proteins combining Chou’s PseAAC and PsePSSM based on wavelet denoising

    Science.gov (United States)

    Chen, Cheng; Chen, Rui-Xin; Wang, Lei; Wang, Ming-Hui; Zhang, Yan

    2017-01-01

    Apoptosis proteins subcellular localization information are very important for understanding the mechanism of programmed cell death and the development of drugs. The prediction of subcellular localization of an apoptosis protein is still a challenging task because the prediction of apoptosis proteins subcellular localization can help to understand their function and the role of metabolic processes. In this paper, we propose a novel method for protein subcellular localization prediction. Firstly, the features of the protein sequence are extracted by combining Chou's pseudo amino acid composition (PseAAC) and pseudo-position specific scoring matrix (PsePSSM), then the feature information of the extracted is denoised by two-dimensional (2-D) wavelet denoising. Finally, the optimal feature vectors are input to the SVM classifier to predict subcellular location of apoptosis proteins. Quite promising predictions are obtained using the jackknife test on three widely used datasets and compared with other state-of-the-art methods. The results indicate that the method proposed in this paper can remarkably improve the prediction accuracy of apoptosis protein subcellular localization, which will be a supplementary tool for future proteomics research. PMID:29296195

  18. Determinations of enthalpy and partial molar enthalpy in the alloys Bi–Cd–Ga–In–Zn, Bi–Cd–Ga–Zn and Au–Cu–Sn

    International Nuclear Information System (INIS)

    Arslan, Hüseyin

    2015-01-01

    In the present study, the relations of thermodynamic associated with Chou's general solution model (GSM), the models of Muggianu and Toop have been used in order to calculate the mixing enthalpy and partial molar mixing enthalpy of mixing of Bi–Cd–Ga–In–Zn, Bi–Cd–Ga–Zn with equimolar section at a temperature of 730 K and Au–Cu–Sn with the section x Au /x Cu = 1/1 on the entire molar fraction range as a function of alloy composition at a temperature of 900 K. Some negativities are reported in the selected alloys mentioned above, particularly at high temperatures for the human health as well as difficulties in experimental measurement and high costs. Moreover, aim of us is to close the current article gap seen in the literature. In order to close the current gap seen in the literature, the article on the thermodynamic properties of the Bi–Cd–Ga–In–Zn alloys are presented in this study. - Highlights: • Thermodynamic properties of alloys in the study in given conditions were treated. • The activity of Bi seen in all models shows greatly positive deviation from ideality. • The enthalpy of Sn shows small negative values in x Au /x Cu = 1 at 900 K. • The activity of Sn shows negative deviation from ideality in the same conditions

  19. Soft Skill Competencies, Hard Skill Competencies, and Intention to Become Entrepreneur of Vocational Graduates (P.119-132

    Directory of Open Access Journals (Sweden)

    Benedicta Prihatin Dwi Riyanti

    2017-02-01

    Full Text Available This study aimed to determine the effect of soft skill competencies and hard skill competencies to the intention to become entrepreneur in the vocational school graduates. Hard skill entrepreneurial competencies are competencies that are needed to running business. Meanwhile for soft skill competencies are competencies related to aspects of personality and cognitive style. Population in this research is vocational graduates in Jakarta and Jogjakarta. The sampling technique used is incidental sampling. We used measuring instruments as follow:  the intention to become entrepreneur of Shapero & Sokol (in Riyanti, 2009. soft skill competencies of Spencer & Spencer (1993 and hard skill competencies of Chou. Shen. Hsiou & Chen. 2010. The regression analysis of the 258 respondents showed significant effect of soft skill competencies (initiative. self-confidence and assertiveness to the intention to become entrepreneur in the vocational school graduates. There are significant effect hard skill competencies (human resources capability competency and production capability competency to the intention to be entrepreneur. Based on the results. we suggested that the learning process should be more emphasis on direct practice so that more competencies can be formed on vocational school graduates.Keywords: entrepreneur,competency,intention

  20. Soft Skill Competencies, Hard Skill Competencies, and Intention to Become Entrepreneur of Vocational Graduates

    Directory of Open Access Journals (Sweden)

    Benedicta Prihatin Dwi Riyanti

    2016-08-01

    Full Text Available This study aimed to determine the effect of soft skill competencies and hard skill competencies to the intention to become entrepreneur in the vocational school graduates. Hard skill entrepreneurial competencies are competencies that are needed to running business. Meanwhile for soft skill competencies are competencies related to aspects of personality and cognitive style. Population in this research is vocational graduates in Jakarta and Jogjakarta. The sampling technique used is incidental sampling. We used measuring instruments as follow: the intention to become entrepreneur of Shapero & Sokol (in Riyanti, 2009. soft skill competencies of Spencer & Spencer (1993 and hard skill competencies of Chou. Shen. Hsiou & Chen. 2010. The regression analysis of the 258 respondents showed significant effect of soft skill competencies (initiative. self-confidence and assertiveness to the intention to become entrepreneur in the vocational school graduates. There are significant effect hard skill competencies (human resources capability competency and production capability competency to the intention to be entrepreneur. Based on the results. we suggested that the learning process should be more emphasis on direct practice so that more competencies can be formed on vocational school graduates.

  1. Analysis of long-lived particle decays with the MATHUSLA detector

    Science.gov (United States)

    Curtin, David; Peskin, Michael E.

    2018-01-01

    The MATHUSLA detector is a simple large-volume tracking detector to be located on the surface above one of the general-purpose experiments at the Large Hadron Collider. This detector was proposed in [J. P. Chou, D. Curtin, and H. J. Lubatti, Phys. Lett. B 767, 29 (2017), 10.1016/j.physletb.2017.01.043] to detect exotic, neutral, long-lived particles that might be produced in high-energy proton-proton collisions. In this paper, we consider the use of the limited information that MATHULSA would provide on the decay products of the long-lived particle. For the case in which the long-lived particle is pair-produced in Higgs boson decays, we show that it is possible to measure the mass of this particle and determine the dominant decay mode with less than 100 observed events. We discuss the ability of MATHUSLA to distinguish the production mode of the long-lived particle and to determine its mass and spin in more general cases.

  2. Imaging Prostate Cancer Invasion with Multi-Nuclear Magnetic Resonance Methods: The Metabolic Boyden Chamber

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    Ulrich Pilatus

    2000-05-01

    Full Text Available The physiological milieu within solid tumors can influence invasion and metastasis. To determine the impact of the physiological environment and cellular metabolism on cancer cell invasion, it is necessary to measure invasion during well-controlled modulation of the physiological environment. Recently, we demonstrated that magnetic resonance imaging can be used to monitor cancer cell invasion into a Matrigel layer [Artemov D, Pilatus U, Chou S, Mori N, Nelson JB, and Bhujwalla ZM. (1999. Dynamics of prostate cancer cell invasion studied in vitro by NMR microscopy. Mag Res Med 42, 277–282.]. Here we have developed an invasion assay (“Metabolic Boyden Chamber” that combines this capability with the properties of our isolated cell perfusion system. Long-term experiments can be performed to determine invasion as well as cellular metabolism under controlled environmental conditions. To characterize the assay, we performed experiments with prostate cancer cell lines preselected for different invasive characteristics. The results showed invasion into, and degradation of the Matrigel layer, by the highly invasive/metastatic line (MatLyLu, whereas no significant changes were observed for the less invasive/metastatic cell line (DU-145. With this assay, invasion and metabolism was measured dynamically, together with oxygen tensions within the cellular environment and within the Matrigel layer. Such a system can be used to identify physiological and metabolic characteristics that promote invasion, and evaluate therapeutic interventions to inhibit invasion.

  3. Cytotoxic effects of the newly-developed chemotherapeutic agents 17-AAG in combination with oxaliplatin and capecitabine in colorectal cancer cell lines.

    Science.gov (United States)

    Mohammadian, Mahshid; Zeynali, Shima; Azarbaijani, Anahita Fathi; Khadem Ansari, Mohammad Hassan; Kheradmand, Fatemeh

    2017-12-01

    The use of heat shock protein 90 inhibitors like 17-allylamino-17-demethoxy-geldanamycin (17-AAG) has been recently introduced as an attractive anticancer therapy. It has been shown that 17-AAG may potentiate the inhibitory effects of some classical anticolorectal cancer (CRC) agents. In this study, two panels of colorectal carcinoma cell lines were used to evaluate the effects of 17-AAG in combination with capecitabine and oxaliplatin as double and triple combination therapies on the proliferation of CRC cell lines. HT-29 and all HCT-116 cell lines were seeded in culture media in the presence of different doses of the mentioned drugs in single, double, and triple combinations. Water-soluble tetrazolium-1 (WST-1) assay was used to investigate cell proliferation 24 h after treatments. Then, dose-response curves were plotted using WST-1outputs, and IC 50 values were determined. For double and triple combinations respectively 0.5 × IC 50 and 0.25 × IC 50 were used. Data was analyzed with the software CompuSyn. Drug interactions were analyzed using Chou-Talalay method to calculate the combination index (CI).The data revealed that 17-AAG shows a potent synergistic interaction (CI 1) in HT-29 and a synergistic effect (CI AAG with oxaliplatin or capecitabine might be effective against HCT-116 and HT-29 cell lines. However, in triple combinations, positive results were seen only against HCT-116. Further investigation is suggested to confirm the effectiveness of these combinations in clinical trials.

  4. In vitro testing of drug combinations employing nilotinib and alkylating agents with regard to pretransplant conditioning treatment of advanced-phase chronic myeloid leukemia.

    Science.gov (United States)

    Radujkovic, Aleksandar; Luft, Thomas; Dreger, Peter; Ho, Anthony D; Jens Zeller, W; Fruehauf, Stefan; Topaly, Julian

    2014-08-01

    The prognosis of patients with advanced-phase chronic myeloid leukemia (CML) remains dismal despite the availability of targeted therapies and allogeneic stem cell transplantation (allo-SCT). Increasing the antileukemic efficacy of the pretransplant conditioning regimen may be a strategy to increase remission rates and duration. We therefore investigated the antiproliferative effects of nilotinib in combination with drugs that are usually used for conditioning: the alkylating agents mafosfamide, treosulfan, and busulfan. Drug combinations were tested in vitro in different imatinib-sensitive and imatinib-resistant BCR-ABL-positive cell lines. A tetrazolium-based MTT assay was used for the assessment and quantification of growth inhibition after exposure to alkylating agents alone or to combinations with nilotinib. Drug interaction was analyzed using the median-effect method of Chou and Talalay, and combination index (CI) values were calculated according to the classic isobologram equation. Treatment of imatinib-sensitive, BCR-ABL-positive K562 and LAMA84 cells with nilotinib in combination with mafosfamide, treosulfan, or busulfan resulted in synergistic (CI 1) effects, respectively. In imatinib-resistant K562-R and LAMA84-R cells, all applied drug combinations were synergistic (CI conditioning regimens for allo-SCT in advanced-phase CML.

  5. The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells

    Science.gov (United States)

    Wei, Ning; Chu, Edward; Wu, Shao-yu; Wipf, Peter; Schmitz, John C.

    2015-01-01

    Metastatic colorectal cancer (mCRC) remains a major public health problem, and diagnosis of metastatic disease is usually associated with poor prognosis. The multi-kinase inhibitor regorafenib was approved in 2013 in the U.S. for the treatment of mCRC patients who progressed after standard therapies. However, the clinical efficacy of regorafenib is quite limited. One potential strategy to improve mCRC therapy is to combine agents that target key cellular signaling pathways, which may lead to synergistic enhancement of antitumor efficacy and overcome cellular drug resistance. Protein kinase D (PKD), a family of serine/threonine kinases, mediates key signaling pathways implicated in multiple cellular processes. Herein, we evaluated the combination of regorafenib with a PKD inhibitor in several human CRC cells. Using the Chou-Talalay model, the combination index values for this combination treatment demonstrated synergistic effects on inhibition of cell proliferation and clonal formation. This drug combination resulted in induction of apoptosis as determined by flow cytometry, increased PARP cleavage, and decreased activation of the anti-apoptotic protein HSP27. This combination also yielded enhanced inhibition of ERK, AKT, and NF-κB signaling. Taken together, PKD inhibition in combination with regorafenib appears to be a promising strategy for the treatment of mCRC. PMID:25544765

  6. Computational studies on LiP H isolated from Ganoderma lucidum GD88

    Directory of Open Access Journals (Sweden)

    Parambayil Nayana

    2015-01-01

    Full Text Available Ganoderma lucidum is a basidiomycete fungus that produces ligninase for the modification of lignin. Lignin peroxidase (LiP is a glycoprotein that acts on the recalcitrant cell wall component lignin. In the present study, the phylogenetic analysis of Ganoderma lucidum GD88 with the partial coding sequence (cds of other LiP isoforms was performed using MEGA6. After determination of the open reading frame, the +3 frame nucleotide sequence was converted to protein using the EMBOSS Transseq and the secondary structure was predicted using the Chou and Fasman Secondary Structure Prediction server (CFSSP. Protein modeling was also performed by SWISS-MODEL. The obtained result shows that the lipH partial cds of Ganoderma lucidum GD88 is homologous to the lipD gene of Phanerochaete chrysosporium. The secondary structure prediction result revealed that the percent content of the helix (67 is higher than the percent contents of sheet (53.4 and turns (13.6. According to the generated model, LiP H protein is a homodimer with chains A and B. The heme acts as a ligand and plays a major role in structure stabilization.

  7. Thermoresponsive nanocomposite gel for local drug delivery to suppress the growth of glioma by inducing autophagy.

    Science.gov (United States)

    Ding, Li; Wang, Qi; Shen, Ming; Sun, Ying; Zhang, Xiangyu; Huang, Can; Chen, Jianhua; Li, Rongxin; Duan, Yourong

    2017-07-03

    Although the treatments of malignant glioma include surgery, radiotherapy and chemotherapy by oral drug administration, the prognosis of patients with glioma remains very poor. We developed a polyethylene glycol-dipalmitoylphosphatidyle- thanoiamine (mPEG-DPPE) calcium phosphate nanoparticles (NPs) injectable thermoresponsive hydrogel (nanocomposite gel) that could provide a sustained and local delivery of paclitaxel (PTX) and temozolomide (TMZ). In addition, the proportion of PTX and TMZ for the optimal synergistic antiglioma effect on C6 cells was determined to be 1:100 (w/w) by the Chou and Talalay method. Our results clearly indicated that the autophagy induced by PTX:TMZ NPs plays an important role in regulating tumor cell death, while autophagy inhibition dramatically reverses the antitumor effect of PTX:TMZ NPs, suggesting that antiproliferative autophagy occurs in response to PTX:TMZ NPs treatment. The antitumor efficacy of the PTX:TMZ NP-loaded gel was evaluated in situ using C6 tumor-bearing rats, and the PTX:TMZ NP-loaded gel exhibited superior antitumor performance. The antitumor effects of the nanocomposite gel in vivo were shown to correlate with autophagic cell death in this study. The in vivo results further confirmed the advantages of such a strategy. The present study may provide evidence supporting the development of nanomedicine for potential clinical application.

  8. Chinese energy demand falls back

    Energy Technology Data Exchange (ETDEWEB)

    Smil, V.

    1977-10-01

    China's growth in energy demand and production declined in 1976, partly because of difficulty of sustaining a rapid 5.4 percent growth and partly because of the disruptions caused by a major earthquake and the deaths of Mao Tse-Tung and Chou En-Lai. The earthquake, which damaged all mines, the power station, refineries, and transportation lines in the Tangshan area, has had serious economic consequences. The failure to back up a growing coal industry with adequate investments and mechanization was recognized in 1975 and prompted a 10-year modernization program. Progress has been made with new mine shafts, pulverizing equipment, and the use of small mines for local industries. Oil and gas production increased after the discovery of new fields and the use of new technology in the hydrocarbon industries. Ports and terminal facilities to handle large tankers will increase China's oil export traffic. Electricity generation increased with new power facilities, although China's dependence on human and animal power is still a major factor. Changes in energy consumption patterns are developing, but industry still represents 50 percent and transportation less than 10 percent. (DCK)

  9. pLoc-mPlant: predict subcellular localization of multi-location plant proteins by incorporating the optimal GO information into general PseAAC.

    Science.gov (United States)

    Cheng, Xiang; Xiao, Xuan; Chou, Kuo-Chen

    2017-08-22

    One of the fundamental goals in cellular biochemistry is to identify the functions of proteins in the context of compartments that organize them in the cellular environment. To realize this, it is indispensable to develop an automated method for fast and accurate identification of the subcellular locations of uncharacterized proteins. The current study is focused on plant protein subcellular location prediction based on the sequence information alone. Although considerable efforts have been made in this regard, the problem is far from being solved yet. Most of the existing methods can be used to deal with single-location proteins only. Actually, proteins with multi-locations may have some special biological functions. This kind of multiplex protein is particularly important for both basic research and drug design. Using the multi-label theory, we present a new predictor called "pLoc-mPlant" by extracting the optimal GO (Gene Ontology) information into the Chou's general PseAAC (Pseudo Amino Acid Composition). Rigorous cross-validation on the same stringent benchmark dataset indicated that the proposed pLoc-mPlant predictor is remarkably superior to iLoc-Plant, the state-of-the-art method for predicting plant protein subcellular localization. To maximize the convenience of most experimental scientists, a user-friendly web-server for the new predictor has been established at , by which users can easily get their desired results without the need to go through the complicated mathematics involved.

  10. Antecedents dan Consequences dari Feedback-Seeking Orientation di Costa Crociere

    Directory of Open Access Journals (Sweden)

    Trias Septyoari Putranto

    2012-11-01

    Full Text Available Cruise ship, as a home away from home place, which has a perisable product with the complex activity from their employees, certainly should have a potential character to keep sustainable in the service industry. To keep it sustainable, the management should have a good relationship with their employees and customers. In this research, a good relationship with the employee can be created by a good motivation, leadership, and it has an effect with the feedback. This condition can be seen by the employees’ job satisfaction. The management can drive a conductive working condition to help generate a good service climate. The research was undertaken in a cruise ship service industry in Italy. The purpose of this study was to evaluate the effect of employees’ motivation and leadership of feedback-seeking orientation and their job satisfaction. Sample was collected from 100 respondents, the employees’, with simple random sampling method, questionnaire, and an interview with the management. The collected data was analyzed with path analysis which using the statistic program LISREL 8.7 for Windows, and the questionnaire was adopted from Paswan (2005 and Chou (2002. The findings suggest that motivation and leadership have a significant effect on feedback-seeking orientation. Besides, feedbackseeking orientation also has a significant effect on job satisfaction.

  11. RBSURFpred: Modeling protein accessible surface area in real and binary space using regularized and optimized regression.

    Science.gov (United States)

    Tarafder, Sumit; Toukir Ahmed, Md; Iqbal, Sumaiya; Tamjidul Hoque, Md; Sohel Rahman, M

    2018-03-14

    Accessible surface area (ASA) of a protein residue is an effective feature for protein structure prediction, binding region identification, fold recognition problems etc. Improving the prediction of ASA by the application of effective feature variables is a challenging but explorable task to consider, specially in the field of machine learning. Among the existing predictors of ASA, REGAd 3 p is a highly accurate ASA predictor which is based on regularized exact regression with polynomial kernel of degree 3. In this work, we present a new predictor RBSURFpred, which extends REGAd 3 p on several dimensions by incorporating 58 physicochemical, evolutionary and structural properties into 9-tuple peptides via Chou's general PseAAC, which allowed us to obtain higher accuracies in predicting both real-valued and binary ASA. We have compared RBSURFpred for both real and binary space predictions with state-of-the-art predictors, such as REGAd 3 p and SPIDER2. We also have carried out a rigorous analysis of the performance of RBSURFpred in terms of different amino acids and their properties, and also with biologically relevant case-studies. The performance of RBSURFpred establishes itself as a useful tool for the community. Copyright © 2018 Elsevier Ltd. All rights reserved.

  12. Topical difluprednate for the treatment of Harada’s disease

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    Onishi SM

    2015-01-01

    Full Text Available Spencer M Onishi, Masumi G Asahi, Calvin Chou, Ron P Gallemore Retina Macula Institute, Torrance, CA, USA Purpose: To describe the use of topical difluprednate for treatment of patients who presented with Harada’s disease.Methods: Retrospective case series of patients managed with topical difluprednate alone at the onset of the diagnosis. The patients were followed with optical coherence tomography (OCT and fluorescein angiography.Results: In our three cases, complete resolution of the exudative detachments with improvement in visual acuity was achieved in each case. Central macular thickness was reduced by a mean of 365±222 µm. Initial loading dose was one drop every hour while awake, followed by a variable tapering regimen. Leakage on fluorescein angiography and exudative detachments on OCT both responded to treatment with difluprednate. In two of the three cases, the patients recovered vision to 20/20, and the third case recovered to 20/25. Steroid-induced glaucoma was observed and managed with one to two glaucoma drops as needed.Conclusion: Difluprednate is effective for managing ocular manifestations of Harada’s disease. Further studies of this drug for the management of noninfectious posterior uveitis are warranted. Keywords: serous retinal detachment, noninfectious posterior uveitis, steroid

  13. [Evaluate drug interaction of multi-components in Morus alba leaves based on α-glucosidase inhibitory activity].

    Science.gov (United States)

    Ji, Tao; Su, Shu-Lan; Guo, Sheng; Qian, Da-Wei; Ouyang, Zhen; Duan, Jin-Ao

    2016-06-01

    Column chromatography was used for enrichment and separation of flavonoids, alkaloids and polysaccharides from the extracts of Morus alba leaves; glucose oxidase method was used with sucrose as the substrate to evaluate the multi-components of M. alba leaves in α-glucosidase inhibitory models; isobole method, Chou-Talalay combination index analysis and isobolographic analysis were used to evaluate the interaction effects and dose-effect characteristics of two components, providing scientific basis for revealing the hpyerglycemic mechanism of M. alba leaves. The components analysis showed that flavonoid content was 5.3%; organic phenolic acids content was 10.8%; DNJ content was 39.4%; and polysaccharide content was 18.9%. Activity evaluation results demonstrated that flavonoids, alkaloids and polysaccharides of M. alba leaves had significant inhibitory effects on α-glucosidase, and the inhibitory rate was increased with the increasing concentration. Alkaloids showed most significant inhibitory effects among these three components. Both compatibility of alkaloids and flavonoids, and the compatibility of alkaloids and polysaccharides demonstrated synergistic effects, but the compatibility of flavonoids and polysaccharides showed no obvious synergistic effects. The results have confirmed the interaction of multi-components from M. alba leaves to regulate blood sugar, and provided scientific basis for revealing hpyerglycemic effectiveness and mechanism of the multi-components from M. alba leaves. Copyright© by the Chinese Pharmaceutical Association.

  14. New Insights in Routine Procedure for Mathematical Evaluation of in vitro Cytotoxicity Data from Cancer Cell Lines

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    Maya M. Zaharieva

    2018-06-01

    Full Text Available In oncopharmacology, the common procedure to evaluate median-effect concentrations (IC50 on experimental data is based on the use of well-established kinetic models representing inhibition effects of drugs on human cancer cell lines. Several widespread software programs, such as GraphPad Prism and CompuSyn offer possibilities for calculation of IC50 through the model of Chou. In recent study, we analyzed the results from those two software programs and compared them with the non-linear programming procedure written by us in the MAPLE symbolic software. The last evaluated IC50 more precisely and the correlation coefficient R value was better in all trails. We demonstrated the efficiency of non-linear programming procedures in examples of two cancer cell lines treated with three different drugs. The response surface analysis showed the potential of the applied kinetic model. As a result, we were able to define better the IC50 values and to use them in planning further experiments in human cancer cell lines related to single drug influence and drug-drug interference.

  15. A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase.

    Directory of Open Access Journals (Sweden)

    Kenneth W Yip

    Full Text Available Uroporphyrinogen decarboxylase (UROD catalyzes the conversion of uroporphyrinogen to coproporphyrinogen during heme biosynthesis. This enzyme was recently identified as a potential anticancer target; its inhibition leads to an increase in reactive oxygen species, likely mediated by the Fenton reaction, thereby decreasing cancer cell viability and working in cooperation with radiation and/or cisplatin. Because there is no known chemical UROD inhibitor suitable for use in translational studies, we aimed to design, synthesize, and characterize such a compound. Initial in silico-based design and docking analyses identified a potential porphyrin analogue that was subsequently synthesized. This species, a porphodimethene (named PI-16, was found to inhibit UROD in an enzymatic assay (IC50 = 9.9 µM, but did not affect porphobilinogen deaminase (at 62.5 µM, thereby exhibiting specificity. In cellular assays, PI-16 reduced the viability of FaDu and ME-180 cancer cells with half maximal effective concentrations of 22.7 µM and 26.9 µM, respectively, and only minimally affected normal oral epithelial (NOE cells. PI-16 also combined effectively with radiation and cisplatin, with potent synergy being observed in the case of cisplatin in FaDu cells (Chou-Talalay combination index <1. This work presents the first known synthetic UROD inhibitor, and sets the foundation for the design, synthesis, and characterization of higher affinity and more effective UROD inhibitors.

  16. Review of the clavatus group of the lanternfly genus Pyrops (Hemiptera: Fulgoromorpha: Fulgoridae

    Directory of Open Access Journals (Sweden)

    Jérôme Constant

    2017-03-01

    Full Text Available The clavatus group of Pyrops Spinola, 1839 is reviewed and redefined. The new combination Pyrops atroalbus (Distant, 1918 comb. nov. is proposed, as atroalbus is reinstated as a full species from status of subspecies of Pyrops watanabei (Matsumura, 1913. Pyrops nigripennis (Chou & Wang, 1985 and Pyrops clavatus mizunumai (Sato & Nagai, 1994 are proposed as junior synonyms of P. clavatus (Westwood, 1839. The Philippine species P. polillensis (Baker, 1925 is removed from the group and not attributed to any of the currently defined species groups. Hence, the clavatus group is restricted to continental Southeast Asia and Taiwan and contains three species: P. atroalbus comb. nov., P. clavatus and P. watanabei. A key to the species of the group and illustrations of the male genitalia are provided. The intraspecific colour variation in the group is discussed and illustrated. The genus Pyrops is removed from the subfamily Fulgorinae and not attributed to any of the currently defined subfamilies of Fulgoridae.

  17. Brain meningioma with initial manifestation similar to cervical radiculopathy: a case report

    Directory of Open Access Journals (Sweden)

    Huang YH

    2014-06-01

    Full Text Available Yu-Hsuan Huang,1,* Chang-Zern Hong,2,* Wei-Ting Wu,1 Kun-Ta Li,3 Li-Wei Chou1,4¹Department of Physical Medicine and Rehabilitation, China Medical University Hospital, 2Department of Physical Therapy, Hungkuang University, 3Department of Emergency Medicine, China Medical University Hospital, 4School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan*These authors contributed equally to this workAbstract: Meningiomas are the most common benign brain tumors, and are characterized by slow growth and a long asymptomatic period. Once the tumor becomes symptomatic, the various presentations may be related to the location and compression of adjacent structures. Meningioma is primarily treated through surgical intervention, and thus earlier diagnosis is likely to result in better prognosis. The symptoms of the meningioma may mimic other diseases, making precise diagnosis difficult, which will then delay treatment. We report a case of brain meningioma that showed initial signs and symptoms similar to cervical radiculopathy. The symptoms extended gradually, and the ultimate diagnosis of meningioma was confirmed based on brain-image studies. After brain-tumor excision, postoperation radiotherapy, and aggressive rehabilitation, the patient was able to perform better in daily activities.Keywords: hemiplegia, menigioma, paresthesia, radiculopathy, rehabilitation

  18. Structure and conformational changes of crotamine

    International Nuclear Information System (INIS)

    Beltran, J.R.; Mascarenhas, Y.P.; Cid, H.; Craievich, A.F.; Laure, C.J.

    1983-01-01

    The secondary structure of crotamine is predicted by the simultaneous use of the statistical method of Chou and Fasman and the method of hydrofobicity profiles resulting in 19% of helix- and 45% of β-structures, in agreement both with previous results obtained from ORD and laser spectroscopy. It allows for the three disulphide bridges and is consistent with a long ellipsoidal shape for the molecule. From SAXS curves measured at several concentrations the radius of gyration, volume and surface of the molecule are obtained. The knowledge of these parameters enables one to conclude that the overall shape of the crotamine molecule can be described by a prolate (long) ellipsoide of semi-axis a, a and νa with ν = 2.3, in agreement with the above prediction. The radius of gyration of crotamine is also determined as a function of pH. An important change found for pH values from 9.5 to 12.5 is atributed to a dominant effect of molecular aggregation. (Author) [pt

  19. Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation

    Science.gov (United States)

    Brahmbhatt, Meera; Gundala, Sushma R.; Asif, Ghazia; Shamsi, Shahab A; Aneja, Ritu

    2014-01-01

    Dietary phytochemicals offer non-toxic therapeutic management as well as chemopreventive intervention for slow-growing prostate cancers. However, the limited success of several single-agent clinical trials suggest a paradigm shift that the health benefits of fruits and vegetables are not ascribable due to individual phytochemicals rather may be ascribed to but to synergistic interactions among them. We recently reported growth-inhibiting and apoptosis-inducing properties of ginger extract (GE) in in vitro and in vivo prostate cancer models. Nevertheless, the nature of interactions among the constituent ginger biophenolics, viz. 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogoal, remains elusive. Here we show antiproliferative efficacy of the most-active GE biophenolics as single-agents and in binary combinations, and investigate the nature of their interactions using the Chou-Talalay combination-index (CI) method. Our data demonstrate that binary combinations of ginger phytochemicals synergistically inhibit proliferation of PC-3 cells with CI values ranging from 0.03-0.88. To appreciate synergy among phytochemicals present in GE, the natural abundance of ginger biophenolics was quantitated using LC-UV/MS. Interestingly, combining GE with its constituents (in particular, 6-gingerol) resulted in significant augmentation of GE’s antiproliferative activity. These data generate compelling grounds for further preclinical evaluation of GE alone and in combination with individual ginger biophenols for prostate cancer management. PMID:23441614

  20. An in-depth analysis of the biological functional studies based on the NMR M2 channel structure of influenza A virus

    International Nuclear Information System (INIS)

    Huang Ribo; Du Qishi; Wang Chenghua; Chou, K.-C.

    2008-01-01

    The long-sought three-dimensional structure of the M2 proton channel of influenza A virus was successfully determined recently by the high-resolution NMR [J.R. Schnell, J.J. Chou, Structure and mechanism of the M2 proton channel of influenza A virus, Nature 451 (2008) 591-595]. Such a milestone work has provided a solid structural basis for studying drug-resistance problems. However, the action mechanism revealed from the NMR structure is completely different from the traditional view and hence prone to be misinterpreted as 'conflicting' with some previous biological functional studies. To clarify this kind of confusion, an in-depth analysis was performed for these functional studies, particularly for the mutations D44N, D44A and N44D on position 44, and the mutations on positions 27-38. The analyzed results have provided not only compelling evidences to further validate the NMR structure but also very useful clues for dealing with the drug-resistance problems and developing new effective drugs against H5N1 avian influenza virus, an impending threat to human beings.

  1. Statistical evaluation of effluent monitoring data for the 200 Area Treated Effluent Disposal Facility

    International Nuclear Information System (INIS)

    Chou, C.J.; Johnson, V.G.

    2000-01-01

    The 200 Area Treated Effluent Disposal Facility (TEDF) consists of a pair of infiltration basins that receive wastewater originating from the 200 West and 200 East Areas of the Hanford Site. TEDF has been in operation since 1995 and is regulated by State Waste Discharge Permit ST 4502 (Ecology 1995) under the authority of Chapter 90.48 Revised Code of Washington (RCW) and Washington Administrative Code (WAC) Chapter 173-216. The permit stipulates monitoring requirements for effluent (or end-of-pipe) discharges and groundwater monitoring for TEDF. Groundwater monitoring began in 1992 prior to TEDF construction. Routine effluent monitoring in accordance with the permit requirements began in late April 1995 when the facility began operations. The State Waste Discharge Permit ST 4502 included a special permit condition (S.6). This condition specified a statistical study of the variability of permitted constituents in the effluent from TEDF during its first year of operation. The study was designed to (1) demonstrate compliance with the waste discharge permit; (2) determine the variability of all constituents in the effluent that have enforcement limits, early warning values, and monitoring requirements (WHC 1995); and (3) determine if concentrations of permitted constituents vary with season. Additional and more frequent sampling was conducted for the effluent variability study. Statistical evaluation results were provided in Chou and Johnson (1996). Parts of the original first year sampling and analysis plan (WHC 1995) were continued with routine monitoring required up to the present time

  2. A Nanomechanical Approach on the Measurement of the Elastic Properties of Epoxy Reinforced Carbon Nanotube Nanocomposites

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    G. Mansour

    2013-09-01

    Full Text Available The mechanical behavior of nanocomposite materials with multiwallcarbon nanotube ( MWCNT reinforcements is investigated in the present paper. Epoxy nanocomposites with different weight percentages of carbon nanotubes have been characterized following tensile tests and nanoindentations. The objective of this work was to investigate the efficiency of the reinforcement provided by nanotubes and to examine the agreement between the mechanical properties of the epoxynanocomposites obtained via a macroscale and nanoscale experimentalmethods. Higher increase in modulus was accomplished at weight fraction of nanotube reinforcement of 1 %. The modulus as measured by the tensile tests differed an average of 18% with the results obtained from the nanoindentations, however by utilizing a proper calibration method the resulting data were corrected to only a 3% difference. The modulus results obtained from the experiments were compared with the Halpin - Tsai model and with the Thostenson - Chou model accounting for the outer layer interactions of the nanotube with the hosting matrix. A relatively good agreement was found between the models and the experiments.

  3. Mussel glue protein has an open conformation.

    Science.gov (United States)

    Williams, T; Marumo, K; Waite, J H; Henkens, R W

    1989-03-01

    Both native glue protein from marine mussels and a synthetic nonhydroxylated analog were analyzed by far-uv CD under a variety of conditions. Analysis of the CD spectra using various models strongly suggest a primarily random coil structure for both forms of the protein, a fact also supported by the absence of spectral change for the glue protein upon dilution into 6 M guanidine hydrochloride. The nonhydroxylated analog, which consists of 20 repeats of the peptide sequence Ala-Lys-Pro-Ser-Tyr-Pro-Pro-Thr-Tyr-Lys, was further characterized by enzyme modification using mushroom tyrosinase. Enzymatic hydroxylation of tyrosines was found to be best fit by a model containing two rate constants, 5.6 (+/- 0.6) X 10(-3) and 7.2 (+/- 0.3) X 10(-2) min-1. At equilibrium, HPLC analysis of digests showed nearly 100% conversion of Tyr-9 and only 15 to 35% conversion of Tyr-5. The Chou and Fasman rules for predicting structure were applied to the repeat sequence listed above. The rules predict the absence of alpha helix and beta pleated sheets in the structure of this peptide. On the other hand, beta turns are predicted to be present with Tyr-5 being in the region of highest probability. These data suggest that the protein in solution has only a small amount of secondary structure.

  4. Borehole data package for well 299-W15-41 at single-shell tank waste management Area TX-TY

    International Nuclear Information System (INIS)

    Horton, D.G.; Hodges, F.N.

    2000-01-01

    One new Resource Conservation and Recovery Act (RCRA) groundwater monitoring well was installed at the single-shell tank farm Waste Management Area (WMA) TX-TY during December 1999 and January 2000 in fulfillment of Tri-Party Agreement (Ecology 1996) milestone M-24-43. The well is 299-W15-41 and is located south of the 241-TX tank farm and south of 20th Street in the 200 West Area. A figure shows the locations of all wells in the WMA TX-TY monitoring network. The new well was constructed to the specifications and requirements described in Washington Administrative Code (WAC) 173-160 and WAC 173-303, the groundwater monitoring plan for WMA TX-TY (Caggiano and Goodwin 1991), the assessment plan for WMA TX-TY (Caggiano and Chou 1993), and the description of work for well drilling and installation. This document compiles information on the drilling and construction, well development, pump installation, and sediment testing applicable to well 299-W1 5-41. Appendix A contains the geologist's log, the Well Construction Summary Report, and Well Summary Sheet (as-built diagram) and Appendix B contains borehole geophysical logs. Additional documentation concerning well construction is on file with Bechtel Hanford, Inc., Richland, Washington

  5. Synergistic antifungal effect of chitosan-stabilized selenium nanoparticles synthesized by pulsed laser ablation in liquids against Candida albicans biofilms.

    Science.gov (United States)

    Lara, Humberto H; Guisbiers, Gregory; Mendoza, Jonathan; Mimun, Lawrence C; Vincent, Brandy A; Lopez-Ribot, Jose L; Nash, Kelly L

    2018-01-01

    Candida albicans is a major opportunistic fungal pathogen. One of the most important virulence factors that contribute to the pathogenesis of candidiasis is its ability to form biofilms. A key characteristic of Candida biofilms is their resistance to antifungal agents. Due to significant morbidity and mortality rates related to biofilm-associated drug resistance, there is an urgency to develop novel nanotechnology-based approaches preventing biofilm-related infections. In this study, we report, for the first time, the synthesis of selenium nanoparticles by irradiating selenium pellets by nanosecond pulsed laser ablation in liquid chitosan as a capping agent. Synergy of the fungicidal effect of selenium nanoparticles and chitosan was quantified by the combination index theorem of Chou-Talalay. This drug combination resulted in a potent fungicidal effect against a preformed C. albicans biofilm in a dose-response manner. By advanced electron microscopy techniques, we documented the adhesive and permeabilizing properties of chitosan, therefore allowing selenium nanoparticles to enter as the cell wall of the yeast became disrupted and distorted. Most importantly, we demonstrated a potent quantitative synergistic effect when compounds such as selenium and chitosan are combined. These chitosan-stabilized selenium nanoparticles could be used for ex vivo applications such as sterilizers for surfaces and biomedical devices.

  6. Climate Change Impacts on the Potential Distribution of Eogystia hippophaecolus in China.

    Science.gov (United States)

    Li, Xue; Ge, Xuezhen; Chen, Linghong; Zhang, Linjing; Wang, Tao; Shixiang, Zong

    2018-05-28

    Seabuckthorn carpenter moth, Eogystia hippophaecolus (Hua, Chou, Fang, & Chen, 1990), is the most important boring pest of sea buckthorn (Hippophae rhamnoides L.) in the northwest of China. It is responsible for the death of large areas of H. rhamnoides forest, seriously affecting the ecological environment and economic development in northwestern China. To clarify the potential distribution of E. hippophaecolus in China, the present study used the CLIMEX 4.0.0 model to project the potential distribution of the pest using historical climate data (1981-2010) and simulated future climate data (2011-2100) for China. Under historical climate condition, E. hippophaecolus would be found to be distributed mainly between 27° N - 51° N and 74° E - 134° E, with favorable and highly favorable habitats accounting for 35.2% of the total potential distribution. Under future climate conditions, E. hippophaecolus would be distributed mainly between 27° N - 53° N and 74° E - 134° E, with the possibility of moving in a northwest direction. Under these conditions, the proportion of the total area providing a favorable and highly favorable habitat may decrease to about 33%. These results will help to identify the impact of climate change on the potential distribution of E. hippophaecolus, thereby providing a theoretical basis for monitoring and early forecasting of pest outbreaks. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  7. Association of 5' end neuregulin-1 (NRG1) gene variation with subcortical medial frontal microstructure in humans.

    Science.gov (United States)

    Winterer, Georg; Konrad, Andreas; Vucurevic, Goran; Musso, Francesco; Stoeter, Peter; Dahmen, Norbert

    2008-04-01

    Animal data suggest that the gene neuregulin-1 (NRG1) is involved in neuronal myelination. A haplotype (deCODE) in the 5' end region of the gene was described to double the risk for schizophrenia in an Icelandic population (Stefansson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., Chou, T.T., Hjaltason, O., Birgisdottir, B., Jonsson, H., Gudnadottir, V.G., Gudmundsdottir, E., Bjornsson, A., Ingvarsson, B., Ingason, A., Sigfusson, S., Hardardottir, H., Harvey, R.P., Lai, D., Zhou, M., Brunner, D., Mutel, V., Gonzalo, A., Lemke, G., Sainz, J., Johannesson, G., Andresson, T., Gudbjartsson, D., Manolescu, A., Frigge, M.L., Gurney, M.E., Kong, A., Gulcher, J.R., Petursson, H., Stefansson, K. 2002. Neuregulin-1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71, 877-892). Of note, there is now increasing evidence of disturbed myelination in this illness--particularly in subcortical frontal lobe white matter (Konrad, A., Winterer, G. 2008. Disturbed structural connectivity in schizophrenia--primary factor in pathology or epiphenomenon? Schiz. Bull. [Electronic publication ahead of print]). Therefore, we investigated with diffusion tensor imaging (DTI) the impact of a tagging single nucleotide polymorphism (SNP) from the deCODE haplotype, i.e., SNP8NRG221533, on fractional anisotropy (FA), which reflects structural integrity of white matter. SNP8NRG221533 was selected because it gave the single best uncorrected association with schizophrenia in the original report by Stefansson et al. (Stefansson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., Chou, T.T., Hjaltason, O., Birgisdottir, B., Jonsson, H., Gudnadottir, V.G., Gudmundsdottir, E., Bjornsson, A., Ingvarsson, B., Ingason, A., Sigfusson, S., Hardardottir, H., Harvey, R.P., Lai, D., Zhou, M., Brunner, D., Mutel, V., Gonzalo, A

  8. Determination of Hydrogen Diffusion Coefficients in Fused Silica From 23 to 250°C Using Raman Spectroscopy

    Science.gov (United States)

    Shang, L.; Chou, I.; Lu, W.; Burruss, R. C.

    2008-12-01

    The oxygen buffer technique is routinely used in experimental studies of redox sensitive geochemical reactions at elevated pressures (P) and temperatures (T). However, this technique is limited to T above about 400°C due to the low permeability of sample containers (Pt or Ag-Pd alloys) to hydrogen at lower T. Preliminary results of Chou et al. (Geochim. Cosmochim. Acta, 2008, doi:10.1016/j.gca.2008.07.030) indicate that the use of fused silica capillary (FSC) container may extend this technique to lower T. In this study, hydrogen diffusion coefficients (D) in FSC were determined from 23 to 250°C by measuring the loss of hydrogen from the FSC containers (0.3 mm OD, 0.1 mm ID, and ~10 mm long) with Raman spectroscopy using CO2 as an internal standard. First, CO2 was loaded cryogenically in a FSC capsule (Chou et al., ibid.). The capsule was then inserted in a protective ceramic tube, sealed in a gold capsule containing Fe powder and water, and heated at 300°C under 100 MPa of Ar external P in a cold-seal pressure vessel for several days allowing H2 to diffuse into the capsule. After quench, the Raman spectra were collected and the initial relative concentration of hydrogen in the silica capsule was derived from the peak height ratios between H2 (near 587 cm-1) and CO2 (near 1387 cm- 1). The sample capsule was then heated at a fixed T at one atmosphere to let H2 diffuse out of the capsule, and the changes of hydrogen concentration were monitored by Raman spectroscopy after quench. This process was repeated with different heating durations at 23 (room T), 50, 102, 157, 200, and 250°C. The values of D (in cm2s-1) in FSC were obtained by fitting the observed changes of hydrogen concentration to an equation based on Fick's second law. Our results can be represented by: Ln D (±0.14) = (-39810/RT) - 9.5491 (r2 = 0.9985) where R is the gas constant, and T in Kelvin. The slope corresponds to an activation energy of 39.81 kJ/mol. Our D values are about a half order of

  9. Potential role of pre- and postnatal testosterone levels in attention-deficit/hyperactivity disorder: is there a sex difference?

    Directory of Open Access Journals (Sweden)

    Wang LJ

    2017-05-01

    Full Text Available Liang-Jen Wang,1,2 Miao-Chun Chou,1 Wen-Jiun Chou,1 Min-Jing Lee,1 Sheng-Yu Lee,3,4 Pao-Yen Lin,5 Yi-Hsuan Lee,1 Yi-Hsin Yang,6 Cheng-Fang Yen2,7 1Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 2Department of Psychiatry, School of Medicine, and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 3Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, 4Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, 5Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 6School of Pharmacy, Kaohsiung Medical University Hospital, 7Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Objective: Both prenatal testosterone (T exposure and postnatal T levels have been associated with developing neural circuitry and behavioral systems. This study examined the potential correlation between pre- and postnatal T levels and behavioral and neurocognitive profiles of children with attention-deficit/hyperactivity disorder (ADHD.Methods: Two hundred ADHD patients with a mean age of 8.7±2.0 years (158 boys and 42 girls were recruited. The ratio of the length of the right index finger (2D to that of the right ring finger (4D (2D/4D ratio served as a surrogate of prenatal T exposure, and postnatal T was determined using salivary T concentration. Behavioral symptoms were evaluated using the Swanson, Nolan, and Pelham – Version IV Scale for ADHD (SNAP-IV. Neurocognitive function was assessed using the Wechsler Intelligence Scale for Children – Fourth Edition (WISC-IV and Conners’ Continuous Performance Test (CPT.Results: Lower 2D/4D ratios were associated with comorbid disruptive behavior disorders (t=2.15, P=0.033 in all participants. Among the boys with ADHD, neither 2D/4D ratios nor salivary T levels

  10. Message sidedness in advertising: the moderating roles of need for cognition and time pressure in persuasion.

    Science.gov (United States)

    Kao, Danny Tengti

    2011-08-01

    Persuasion has been extensively researched for decades. Much of this research has focused on different message tactics and their effects on persuasion (e.g., Chang & Chou, 2008; Lafferty, 1999). This research aims to assess whether the persuasion of a specific type of message is influenced by need for cognition (NFC) and time pressure. The 336 undergraduates participated in a 2 (message sidedness: one-sided/two-sided) × 3 (time pressure: low/moderate/high) between-subjects design. Results indicate that two-sided messages tend to elicit more favorable ad attitudes than one-sided messages. As compared with low-NFC individuals, high-NFC individuals are likely to express more favorable ad attitudes, brand attitudes and purchase intention. Moderate time pressure tends to lead to more favorable ad attitudes than low time pressure and high time pressure. In addition, moderate time pressure is likely to elicit more favorable brand attitudes and purchase intentions than high time pressure, but does not elicit more favorable brand attitudes and purchase intentions than low time pressure. Furthermore, when high-NFC individuals are under low or moderate time pressure, two-sided messages are more persuasive than one-sided messages; however, message sidedness does not differentially affect the persuasion when high-NFC individuals are pressed for time. In contrast, one-sided messages are more persuasive than two-sided messages when low-NFC individuals are under low or high time pressure, and two-sided messages are more persuasive than one-sided messages when low-NFC individuals are under moderate time pressure. © 2011 The Author. Scandinavian Journal of Psychology © 2011 The Scandinavian Psychological Associations.

  11. A comparison of complex sleep behaviors with two short-acting Z-hypnosedative drugs in nonpsychotic patients

    Directory of Open Access Journals (Sweden)

    Chen LF

    2013-08-01

    Full Text Available Li-Fen Chen,1 Ching-En Lin,1–3 Yu-Ching Chou,4 Wei-Chung Mao,1,5 Yi-Chyan Chen,1–3 Nian-Sheng Tzeng1,6 1Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City, Taiwan; 2Taipei Tzu Chi Hospital, The Buddhist Medical Foundation, Taipei, Taiwan; 3School of Medicine, Tzu Chi University, Hualien, Taiwan; 4School of Public Health, National Defense Medical Center, Taipei City, Taiwan; 5Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei City, Taiwan; 6Student Counseling Center, National Defense Medical Center, Taipei City, Taiwan Objective: Complex sleep behaviors (CSBs are classified as “parasomnias” in the International Classification of Sleep Disorders, Second Edition (ICSD-2. To realize the potential danger after taking two short-acting Z-hypnosedative drugs, we estimated the incidence of CSBs in nonpsychotic patients in Taiwan. Methods: Subjects (N = 1,220 using zolpidem or zopiclone were enrolled from the psychiatric outpatient clinics of a medical center in Taiwan over a 16-month period in 2006–2007. Subjects with zolpidem (N = 1,132 and subjects with zopiclone (N = 88 were analyzed. All subjects completed a questionnaire that included demographic data and complex sleep behaviors after taking hypnotics. Results: Among zolpidem and zopiclone users, 3.28% of patients reported incidents of somnambulism or amnesic sleep-related behavior problems. The incidence of CSBs with zolpidem and zopiclone were 3.27%, and 3.41%, respectively, which was significantly lower than other studies in Taiwan. Conclusion: These results serve as a reminder for clinicians to make inquiries regarding any unusual performance of parasomnic activities when prescribing zolpidem or zopiclone. Keywords: parasomnia, somnambulism, amnesic sleep-related behavior, sleepwalking, zolpidem, zopiclone

  12. Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells.

    Science.gov (United States)

    Grabinski, Nicole; Ewald, Florian

    2014-12-01

    Ibrutinib (formerly PCI-32765) is a specific, irreversible, and potent inhibitor of Burton's tyrosine kinase (BTK) developed for the treatment of several forms of blood cancer. It is now an FDA-approved drug marketed under the name Imbruvica(TM) (Pharmacyclics, Inc.) and successfully used as an orally administered second-line drug in the treatment of mantle cell lymphoma. Since BTK is predominantly expressed in hematopoietic cells, the sensitivity of solid tumor cells to Ibrutinib has not been analyzed. In this study, we determined the effect of Ibrutinib on breast cancer cells. We demonstrate that Ibrutinib efficiently reduces the phosphorylation of the receptor tyrosine kinases ErbB1, ErbB2 and ErbB3, thereby suppressing AKT and MAPK signaling in ErbB2-positive (ErbB2+) breast cancer cell lines. Treatment with Ibrutinib significantly reduced the viability of ErbB2+ cell lines with IC50 values at nanomolar concentrations, suggesting therapeutic potential of Ibrutinib in breast cancer. Combined treatment with Ibrutinib and the dual PI3K/mTOR inhibitor BEZ235 synergistically reduces cell viability of ErbB2+ breast cancer cells. Combination indices below 0.25 at 50% inhibition of cell viability were determined by the Chou-Talalay method. Therefore, the combination of Ibrutinib and canonical PI3K pathway inhibitors could be a new and effective approach in the treatment of breast cancer with activated ErbB receptors. Ibrutinib could thus become a valuable component of targeted therapy in aggressive ErbB2+ breast cancer.

  13. Density functional theory study of hydrogenation mechanism in Fe-doped Mg(0 0 0 1) surface

    International Nuclear Information System (INIS)

    Wu Guangxin; Zhang Jieyu; Wu Yongquan; Li Qian; Chou Kuochih; Bao Xinhua

    2009-01-01

    Using density functional theory (DFT) in combination with nudged elastic band (NEB) method, the dissociative chemisorptions and diffusion processes of hydrogen on both pure and Fe-doped Mg(0 0 0 1) surfaces are studied. Firstly, the dissociation pathway of H 2 and the relative barrier were investigated. The calculated dissociation barrier (1.08 eV) of hydrogen molecule on a pure Mg(0 0 0 1) surface is in good agreement with comparable experimental and theoretical studies. For the Fe-doped Mg(0 0 0 1) surface, the activated barrier decreases to 0.101 eV due to the strong interaction between the s orbital of H and the d orbital of Fe. Then, the diffusion processes of atomic hydrogen on pure and Fe-doped Mg(0 0 0 1) are presented. The obtained diffusion barrier to the first subsurface is 0.45 eV and 0.98 eV, respectively. Finally, Chou method was used to investigate the hydrogen sorption kinetic mechanism of pure MgH 2 and Mg mixed with 5 at.% Fe atoms composites. The obtained activation energies are 0.87 ± 0.02 and 0.31 ± 0.01 eV for H 2 dissociation on the pure surface and H atom diffusion in Fe-doped Mg surfaces, respectively. It suggests that the rate-controlling step is dissociation of H 2 on the pure Mg surface while it is diffusion of H atom in the Fe-doped Mg surface. And both of fitting data are matching well with our calculation results.

  14. Simultaneous silencing of ACSL4 and induction of GADD45B in hepatocellular carcinoma cells amplifies the synergistic therapeutic effect of aspirin and sorafenib

    Science.gov (United States)

    Xia, Hongping; Lee, Kee Wah; Chen, Jianxiang; Kong, Shik Nie; Sekar, Karthik; Deivasigamani, Amudha; Seshachalam, Veerabrahma Pratap; Goh, Brian Kim Poh; Ooi, London Lucien; Hui, Kam M

    2017-01-01

    Sorafenib is currently the only US Food and Drug Administration (FDA)-approved molecular inhibitor for the systemic therapy of advanced hepatocellular carcinoma (HCC). Aspirin has been studied extensively as an anti-inflammation, cancer preventive and therapeutic agent. However, the potential synergistic therapeutic effects of sorafenib and aspirin on advanced HCC treatment have not been well studied. Drug combination studies and their synergy quantification were performed using the combination index method of Chou-Talalay. The synergistic therapeutic effects of sorafenib and aspirin were evaluated using an orthotopic mouse model of HCC and comprehensive gene profiling analyses were conducted to identify key factors mediating the synergistic therapeutic effects of sorafenib and aspirin. Sorafenib was determined to act synergistically on HCC cells with aspirin in vitro. Using Hep3B and HuH7 HCC cells, it was demonstrated that sorafenib and aspirin acted synergistically to induce apoptosis. Mechanistic studies demonstrated that combining sorafenib and aspirin yielded significant synergistically anti-tumor effects by simultaneously silencing ACSL4 and the induction of GADD45B expression in HCC cells both in vitro and in the orthotopic HCC xenograft mouse model. Importantly, clinical evidence has independently corroborated that survival of HCC patients expressing ACSL4highGADD45Blow was significantly poorer compared to patients with ACSL4lowGADD45Bhigh, thus demonstrating the potential clinical value of combining aspirin and sorafenib for HCC patients expressing ACSL4highGADD45Blow. In conclusion, sorafenib and aspirin provide synergistic therapeutic effects on HCC cells that are achieved through simultaneous silencing of ACSL4 and induction of GADD45B expression. Targeting HCC with ACSL4highGADD45Blow expression with aspirin and sorafenib could provide potential synergistic therapeutic benefits. PMID:28900541

  15. Enhancement of tendon–bone healing via the combination of biodegradable collagen-loaded nanofibrous membranes and a three-dimensional printed bone-anchoring bolt

    Directory of Open Access Journals (Sweden)

    Chou YC

    2016-08-01

    Full Text Available Ying-Chao Chou,1,2 Wen-Lin Yeh,2 Chien-Lin Chao,1 Yung-Heng Hsu,1,2 Yi-Hsun Yu,1,2 Jan-Kan Chen,3 Shih-Jung Liu1,2 1Department of Mechanical Engineering, Chang Gung University, 2Department of Orthopedic Surgery, Chang Gung Memorial Hospital, 3Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan Abstract: A composite biodegradable polymeric model was developed to enhance tendon graft healing. This model included a biodegradable polylactide (PLA bolt as the bone anchor and a poly(D,L-lactide-co-glycolide (PLGA nanofibrous membrane embedded with collagen as a biomimic patch to promote tendon–bone interface integration. Degradation rate and compressive strength of the PLA bolt were measured after immersion in a buffer solution for 3 months. In vitro biochemical characteristics and the nanofibrous matrix were assessed using a water contact angle analyzer, pH meter, and tetrazolium reduction assay. In vivo efficacies of PLGA/collagen nanofibers and PLA bolts for tendon–bone healing were investigated on a rabbit bone tunnel model with histological and tendon pullout tests. The PLGA/collagen-blended nanofibrous membrane was a hydrophilic, stable, and biocompatible scaffold. The PLA bolt was durable for tendon–bone anchoring. Histology showed adequate biocompatibility of the PLA bolt on a medial cortex with progressive bone ingrowth and without tissue overreaction. PLGA nanofibers within the bone tunnel also decreased the tunnel enlargement phenomenon and enhanced tendon–bone integration. Composite polymers of the PLA bolt and PLGA/collagen nanofibrous membrane can effectively promote outcomes of tendon reconstruction in a rabbit model. The composite biodegradable polymeric system may be useful in humans for tendon reconstruction. Keywords: polylactide–polyglycolide nanofibers, PLGA, collagen, 3D printing, polylactide, PLA, bone-anchoring bolts, tendon healing

  16. Simulations of cloudy hyperspectral infrared radiances using the HT-FRTC, a fast PC-based multipurpose radiative transfer code

    Science.gov (United States)

    Havemann, S.; Aumann, H. H.; Desouza-Machado, S. G.

    2017-12-01

    The HT-FRTC uses principal components which cover the spectrum at a very high spectral resolution allowing very fast line-by-line-like, hyperspectral and broadband simulations for satellite-based, airborne and ground-based sensors. Using data from IASI and from the Airborne Research Interferometer Evaluation System (ARIES) on board the FAAM BAE 146 aircraft, variational retrievals in principal component space with HT-FRTC as forward model have demonstrated that valuable information on temperature and humidity profiles and on the cirrus cloud properties can be obtained simultaneously. The NASA/JPL/UMBC cloudy RTM inter-comparison project has been working on a global dataset consisting of 7377 AIRS spectra. Initial simulations with HT-FRTC for this dataset have been promising. A next step taken here is to investigate how sensitive the results are with respect to different assumptions in the cloud modelling. One aspect of this is to study how assumptions about the microphysical and related optical properties of liquid/ice clouds impact the statistics of the agreement between model and observations. The other aspect is about the cloud overlap scheme. Different schemes have been tested (maximum, random, maximum random). As the computational cost increases linearly with the number of cloud columns, it will be investigated if there is an optimal number of columns beyond which there is little additional benefit to be gained. During daytime the high wave number channels of AIRS are affected by solar radiation. With full scattering calculations using a monochromatic version of the Edwards-Slingo radiation code the HT-FRTC can model solar radiation reasonably well, but full scattering calculations are relatively expensive. Pure Chou scaling on the other hand can not properly describe scattering of solar radiation by clouds and requires additional refinements.

  17. Nucleoplasty for treating lumbar disk degenerative low back pain: an outcome prediction analysis

    Directory of Open Access Journals (Sweden)

    Liliang PC

    2016-10-01

    Full Text Available Po-Chou Liliang,1 Kang Lu,1 Cheng-Loong Liang,1 Ya-Wen Chen,2,3 Yu-Duan Tsai,1 Yuan-Kun Tu4 1Department of Neurosurgery, E-Da Hospital, 2Department of Nursing, I-Shou University, 3School of Nursing, Kaohsiung Medical University, 4Department of Orthopedic Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan Purpose: Nucleoplasty is a minimally invasive technique that is considered efficacious in alleviating lumbar disk degenerative low back pain (LBP. The efficacy of nucleoplasty and identified variables that can predict pain relief for nucleoplasty was reported. Patients and methods: Between December 2013 and November 2015, 47 nucleoplasty procedures on 47 lumbar disks in 31 consecutive patients were performed. The outcome was evaluated using a visual analog scale (VAS score. Improvements of ≥50% in VAS scores were considered substantial pain relief. The variables associated with pain relief after nucleoplasty included: 1 age; 2 sex; 3 body mass index; 4 hyperintensity zone at the rear of the disk; 5 hypointensity of the disk; 6 Modic changes of the end plates; 7 spinal instability pain; and 8 discography results. Results: Twenty-one patients (67.7% experienced substantial pain relief. The most common side effects following nucleoplasty were soreness at the needle puncture site (64.5%, numbness in the lower leg (12.9%, and increased intensity of back pain (9.7%. All side effects were transient. Multivariate analysis revealed that the discography results were the most critical predictor for substantial pain relief of nucleoplasty (P=0.03. The sensitivity and specificity of discography were 92.8% and 62.5%, respectively. Conclusion: Discography results could improve the success rate of nucleoplasty in the treatment of disk degenerative LBP. Keywords: low back pain, lumbar disk degenerative, nucleoplasty, discography 

  18. Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1.

    Directory of Open Access Journals (Sweden)

    Jing-Fang Wang

    Full Text Available Human mitochondrial ornithine transporter-1 is reported in coupling with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH syndrome, which is a rare autosomal recessive disorder. For in-depth understanding of the molecular mechanism of the disease, it is crucially important to acquire the 3D structure of human mitochondrial ornithine transporter-1. Since no such structure is available in the current protein structure database, we have developed it via computational approaches based on the recent NMR structure of human mitochondrial uncoupling protein (Berardi MJ, Chou JJ, et al. Nature 2011, 476:109-113. Subsequently, we docked the ligand L-ornithine into the computational structure to search for the favorable binding mode. It was observed that the binding interaction for the most favorable binding mode is featured by six remarkable hydrogen bonds between the receptor and ligand, and that the most favorable binding mode shared the same ligand-binding site with most of the homologous mitochondrial carriers from different organisms, implying that the ligand-binding sites are quite conservative in the mitochondrial carriers family although their sequences similarity is very low with 20% or so. Moreover, according to our structural analysis, the relationship between the disease-causing mutations of human mitochondrial ornithine transporter-1 and the HHH syndrome can be classified into the following three categories: (i the mutation occurs in the pseudo-repeat regions so as to change the region of the protein closer to the mitochondrial matrix; (ii the mutation is directly affecting the substrate binding pocket so as to reduce the substrate binding affinity; (iii the mutation is located in the structural region closer to the intermembrane space that can significantly break the salt bridge networks of the protein. These findings may provide useful insights for in-depth understanding of the molecular mechanism of the HHH syndrome and

  19. Pseudomembranous colitis within radiotherapy field following concurrent chemoradiation therapy: a case report

    Directory of Open Access Journals (Sweden)

    Shen BJ

    2013-01-01

    Full Text Available Bing-Jie Shen,1 Shih-Chiang Lin,2 Pei-Wei Shueng,1,3 Yueh-Hung Chou,4 Li-Ming Tseng,5 Chen-Hsi Hsieh1,6,71Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Division of Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan; 3Department of Radiation Oncology, National Defense Medical Center, Taipei, Taiwan; 4Department of Anatomical Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan; 5Division of Colorectal Surgery, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan; 6Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 7Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, TaiwanAbstract: Development of nonantibiotic-associated pseudomembranous colitis has been reported in patients receiving chemotherapy. Herein, we report a case of a 70-year-old man with diabetes mellitus and hypertension who received concurrent chemoradiation therapy after surgery for stage III pT3N1M0 rectal cancer. After completion of the therapy, the patient presented with a 2-week history of intermittent watery diarrhea (seven to nine times per day. However, the patient was afebrile and laboratory examination revealed no evidence of leukocytosis. Computed tomography disclosed inflammation of the sigmoid colon, infiltrative changes around the anastomotic site, and edematous changes straddling the serosal surface. Colonoscopic examination revealed multiple whitish patches within the radiation field, a finding suggestive of pseudomembranous colitis. No concomitant antibiotics were used during the period of concurrent chemoradiation therapy. Empirical oral metronidazole (500 mg every 8 hours was administrated for 2 weeks. At the end of this treatment, stool culture was negative for Clostridium difficile. Physicians should be aware of the potential for the development of

  20. Révolution : mode d'emploi

    Directory of Open Access Journals (Sweden)

    Marie Camberlin

    2001-09-01

    Full Text Available Pourquoi, en 1948 d'abord, en 1955 ensuite, les tentatives du mouvement des " Yéménites Libres " fondé par Muhammad al-Zubayrî et Ahmad Nu'mân de mettre un terme à l'absolutisme et à l'immobilisme de l'imamat zaydite ont-elles échoué à capitaliser un mécontentement populaire qui était pourtant manifeste ? Pourquoi l'imam Ahmad est-il parvenu à mobiliser avec tant de facilité les masses rurales (des tribus contre le programme de l'intelligentsia éclairée ? Derrière l'inventaire lucide des "erreurs des Libres" que dresse al-Zubayrî, résident certaines péripéties révélatrices des résistances à la modernisation politique au Yémen.Muhammad Mahmûd al-Zubayrî and the mistakes of the Free Yemeni MovementWhy have the attempts of the Free Yemeni movement, founded by Muhammad Mahmûd al-Zubayrî and AΩmad al-Nu'mân to put an end to the absolutism and standstill of the Zaydi Imamate, failed to capitalize on the manifest popular discontent in 1948 and 1955 ? Why did Imam Ahmad manage so easily to gather the tribal rural masses against the project of an enlightened intelligentsia ? This article assesses the mistakes of the Free Yemeni movement as seen by Muhammad al-Zubayrî and relates a number of episodes that reveal some of the resistance to political modernization in Yemen at the time.

  1. Simultaneous, noninvasive, and transdermal extraction of urea and homocysteine by reverse iontophoresis

    Directory of Open Access Journals (Sweden)

    et al

    2011-02-01

    Full Text Available Congo Tak-Shing Ching1,2,3, Tzong-Ru Chou1, Tai-Ping Sun1,2, Shiow-Yuan Huang3, Hsiu-Li Shieh21Graduate Institute of Biomedicine and Biomedical Technology; 2Department of Electrical Engineering, National Chi Nan University, Nantou, Taiwan; 3Department of Photonics and Communication Engineering, Asia University, Taichung, Taiwan, Republic of ChinaBackground: Cardiovascular and kidney diseases are a global public health problem and impose a huge economic burden on health care services. Homocysteine, an amino acid, is associated with coronary heart disease, while urea is a harmful metabolic substance which can be used to reflect kidney function. Monitoring of these two substances is therefore very important. This in vitro study aimed to determine whether homocysteine is extractable transdermally and noninvasively, and whether homocysteine and urea can be extracted simultaneously by reverse iontophoresis.Methods: A diffusion cell incorporated with porcine skin was used for all experiments with the application of a direct current (dc and four different symmetrical biphasic direct currents (SBdc for 12 minutes via Ag/AgCl electrodes. The dc and the SBdc had a current density of 0.3 mA/cm2.Results: The SBdc has four different phase durations of 15 sec, 30 sec, 60 sec, and 180 sec. It was found that homocysteine can be transdermally extracted by reverse iontophoresis. Simultaneous extraction of homocysteine and urea by reverse iontophoresis is also possible.Conclusion: These results suggest that extraction of homocysteine and urea by SBdc are phase duration-dependent, and the optimum mode for simultaneous homocysteine and urea extraction is the SBdc with the phase duration of 60 sec.Keywords: reverse iontophoresis, homocysteine, urea, monitoring, noninvasive, transdermal

  2. Photochemistry and photophysics of the amino and imino tautomers of 1-methylcytosine: tautomerisation as a side product of the radiationless decay.

    Science.gov (United States)

    Li, Quansong; Blancafort, Lluís

    2013-08-01

    The photochemistry and photophysics of the amino-oxo (AO) and imino-oxo (IO) tautomers of 1-methylcytosine are investigated with ab initio calculations, using the CASPT2//CASSCF approach. Our aim is to rationalize recent experimental results which show that the AO tautomer has an excited state lifetime of about 1 ps, similar to cytosine (J.-W. Ho, H.-C. Yen, W.-K. Chou, C.-N. Weng, L.-H. Cheng, H.-Q. Shi, S.-H. Lai and P.-Y. Cheng, J. Phys. Chem. A, 2011, 115, 8406-8418), and that irradiation with wavelengths shorter than 308 nm induces the AO→IO tautomerization (I. Reva, M. J. Nowak, L. Lapinski and R. Fausto, J. Phys. Chem. B, 2012, 116, 5703-5710). For the canonical AO tautomer we find two analogous decay mechanisms to those described previously for cytosine, involving a conical intersection of ethylenic type and one where the amino group is bent out of plane. Decay through these intersections provides an unreactive return path to the AO ground state species. More importantly, we have identified new decay paths that lead from the two intersections to the trans-IO tautomer, without a barrier. These paths provide the possibility of forming the IO tautomer, presumably in small yields, as a side product of the radiationless decay. Thus, we have established for the first time computationally the mechanism of the UV-induced tautomerization, which is compatible with the well-established decay mechanism for cytosine. For the IO tautomer, we also find a mechanism for the excited state interconversion of the cis and trans forms and for efficient radiationless decay through a conical intersection where the imino group is perpendicular to the ring and bent out of the plane. These results are likely to be valid also for cytosine.

  3. Prise en charge de l’infection gonococcique chez les adultes et les jeunes

    Science.gov (United States)

    Pogany, Lisa; Romanowski, Barbara; Robinson, Joan; Gale-Rowe, Margaret; Latham-Carmanico, Cathy; Weir, Christine; Wong, Tom

    2015-01-01

    Résumé Objectif Présenter des recommandations sur la prise en charge de l’infection gonococcique chez les adultes et les jeunes. Qualité des données Les recommandations thérapeutiques des lignes directrices canadiennes sur les infections transmissibles sexuellement reposent sur une recherche documentaire de même que sur des catégories de recommandations et des niveaux de qualité de données déterminés par au moins 2 évaluateurs. Les recommandations ont été revues par des pairs et sont en instance d’approbation par le groupe de travail d’experts. Message principal Les nouvelles recommandations portant sur la prise en charge de l’infection gonococcique chez les adultes et les jeunes préconisent les cultures à titre d’outil diagnostique lorsqu’elles sont pratiques, le traitement par antibiothérapie combinée (ceftriaxone associée à l’azithromycine) et le signalement sans délai de tous les cas dont le traitement a échoué aux autorités de santé publique. Conclusion Si elles sont suivies, ces nouvelles recommandations pourraient réduire l’échec thérapeutique, contribuer à une surveillance plus étroite des tendances à la résistance de Neisseria gonorrhoeae aux antibiotiques et contribuer à prévenir la transmission de gonorrhée résistante à plusieurs médicaments.

  4. Enantiomeric quantification of (S)-(+)-methamphetamine in urine by an immunoaffinity column and liquid chromatography-electrospray-mass spectrometry

    International Nuclear Information System (INIS)

    Lua, Ahai C.; Sutono, Yenny; Chou, T.-Y.

    2006-01-01

    A method using an immunoaffinity column (IAC) and liquid chromatography-electrospray ionization mass spectrometry (LC/MS) for on-line detecting the presence of MA in the effluent was developed for the quantitative and enantiomeric determination of (S)-(+)-methamphetamine (D-MA) in urine. The IAC was made in our laboratory and utilized in the LC/MS to simultaneously extract and separate enantiomers of MA from urine samples. An aqueous ammonium acetate buffer was used as the mobile phase. Urine samples were spiked with racemic deuterated methamphetamine (MA-d 14 ) as internal standard (IS), filtered through a membrane, and injected into the LC/MS without any further pre-treatment. Protonated molecular ion of MA and MA-d 14 (m/z 150 and 164) were isolated and further fragmented, the respective product ions, m/z 119 and 130, were collected for quantitative determination. This is an improvement of our previous method (A.C. Lua, Tsong-Yung Chou, J. Chromatogr. A 967 (2002) 191). In the previous method, MA was separated with HPLC, the efflux was fractionated and each fraction was either determined with an immunoassay or GC/MS. Monitoring of MA in the efflux is tedious and time consuming. Urine samples spiked with different concentrations of D-MA were measured by this method. A linear relationship exists in the 150-1050 ng/mL range, and the detection limit (defined as signal-to-noise ratio 3) of D-MA was determined to be 18 ng/mL. The linearity of the method for D-MA can be described by the equation (Y = 1.415 x 10 -3 X + 0.034, correlation coefficient: r 2 = 0.999). Within run, accuracy and precision (n = 6, relative error: -7.2 to +4.0% and relative standard deviation: 3.8-9.3%) of the method are fairly good

  5. Enantiomeric quantification of (S)-(+)-methamphetamine in urine by an immunoaffinity column and liquid chromatography-electrospray-mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lua, Ahai C. [Department of Laboratory Medicine and Biotechnology and Graduate Institute of Medical Biotechnology, Tzu Chi University, 701, Chung Yang Road Section 3, Hualien, 970, Taiwan (China); Sutono, Yenny [Department of Laboratory Medicine and Biotechnology and Graduate Institute of Medical Biotechnology, Tzu Chi University, 701, Chung Yang Road Section 3, Hualien, 970, Taiwan (China); Chou, T.-Y. [Department of Laboratory Medicine and Biotechnology and Graduate Institute of Medical Biotechnology, Tzu Chi University, 701, Chung Yang Road Section 3, Hualien, 970, Taiwan (China)]. E-mail: cty@mail.tcu.edu.tw

    2006-08-18

    A method using an immunoaffinity column (IAC) and liquid chromatography-electrospray ionization mass spectrometry (LC/MS) for on-line detecting the presence of MA in the effluent was developed for the quantitative and enantiomeric determination of (S)-(+)-methamphetamine (D-MA) in urine. The IAC was made in our laboratory and utilized in the LC/MS to simultaneously extract and separate enantiomers of MA from urine samples. An aqueous ammonium acetate buffer was used as the mobile phase. Urine samples were spiked with racemic deuterated methamphetamine (MA-d{sub 14}) as internal standard (IS), filtered through a membrane, and injected into the LC/MS without any further pre-treatment. Protonated molecular ion of MA and MA-d{sub 14} (m/z 150 and 164) were isolated and further fragmented, the respective product ions, m/z 119 and 130, were collected for quantitative determination. This is an improvement of our previous method (A.C. Lua, Tsong-Yung Chou, J. Chromatogr. A 967 (2002) 191). In the previous method, MA was separated with HPLC, the efflux was fractionated and each fraction was either determined with an immunoassay or GC/MS. Monitoring of MA in the efflux is tedious and time consuming. Urine samples spiked with different concentrations of D-MA were measured by this method. A linear relationship exists in the 150-1050 ng/mL range, and the detection limit (defined as signal-to-noise ratio 3) of D-MA was determined to be 18 ng/mL. The linearity of the method for D-MA can be described by the equation (Y = 1.415 x 10{sup -3} X + 0.034, correlation coefficient: r {sup 2} = 0.999). Within run, accuracy and precision (n = 6, relative error: -7.2 to +4.0% and relative standard deviation: 3.8-9.3%) of the method are fairly good.

  6. Biodegradable drug-eluting nanofiber-enveloped implants for sustained release of high bactericidal concentrations of vancomycin and ceftazidime: in vitro and in vivo studies

    Directory of Open Access Journals (Sweden)

    Hsu YH

    2014-09-01

    Full Text Available Yung-Heng Hsu,1,2 Dave Wei-Chih Chen,1 Chun-Der Tai,3 Ying-Chao Chou,1,2 Shih-Jung Liu,2 Steve Wen-Neng Ueng,1 Err-Cheng Chan4 1Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Guishan Township, 2Department of Mechanical Engineering, Chang Gung University, Guishan Township, 3Graduate Institute of Medical Mechatronics, Chang Gung University, Guishan Township, 4School of Medical Technology, Chang Gung University, Guishan Township, Taiwan Abstract: We developed biodegradable drug-eluting nanofiber-enveloped implants that provided sustained release of vancomycin and ceftazidime. To prepare the biodegradable nanofibrous membranes, poly(D,L-lactide-co-glycolide and the antibiotics were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. They were electrospun into biodegradable drug-eluting membranes, which were then enveloped on the surface of stainless plates. An elution method and a high-performance liquid chromatography assay were employed to characterize the in vivo and in vitro release rates of the antibiotics from the nanofiber-enveloped plates. The results showed that the biodegradable nanofiber-enveloped plates released high concentrations of vancomycin and ceftazidime (well above the minimum inhibitory concentration for more than 3 and 8 weeks in vitro and in vivo, respectively. A bacterial inhibition test was carried out to determine the relative activity of the released antibiotics. The bioactivity ranged from 25% to 100%. In addition, the serum creatinine level remained within the normal range, suggesting that the high vancomycin concentration did not affect renal function. By adopting the electrospinning technique, we will be able to manufacture biodegradable drug-eluting implants for the long-term drug delivery of different antibiotics. Keywords: biodegradable nanofiber-enveloped plates, electrospinning, antibiotics, release characteristics

  7. Automatic Monitoring System Design and Failure Probability Analysis for River Dikes on Steep Channel

    Science.gov (United States)

    Chang, Yin-Lung; Lin, Yi-Jun; Tung, Yeou-Koung

    2017-04-01

    The purposes of this study includes: (1) design an automatic monitoring system for river dike; and (2) develop a framework which enables the determination of dike failure probabilities for various failure modes during a rainstorm. The historical dike failure data collected in this study indicate that most dikes in Taiwan collapsed under the 20-years return period discharge, which means the probability of dike failure is much higher than that of overtopping. We installed the dike monitoring system on the Chiu-She Dike which located on the middle stream of Dajia River, Taiwan. The system includes: (1) vertical distributed pore water pressure sensors in front of and behind the dike; (2) Time Domain Reflectometry (TDR) to measure the displacement of dike; (3) wireless floating device to measure the scouring depth at the toe of dike; and (4) water level gauge. The monitoring system recorded the variation of pore pressure inside the Chiu-She Dike and the scouring depth during Typhoon Megi. The recorded data showed that the highest groundwater level insides the dike occurred 15 hours after the peak discharge. We developed a framework which accounts for the uncertainties from return period discharge, Manning's n, scouring depth, soil cohesion, and friction angle and enables the determination of dike failure probabilities for various failure modes such as overtopping, surface erosion, mass failure, toe sliding and overturning. The framework was applied to Chiu-She, Feng-Chou, and Ke-Chuang Dikes on Dajia River. The results indicate that the toe sliding or overturning has the highest probability than other failure modes. Furthermore, the overall failure probability (integrate different failure modes) reaches 50% under 10-years return period flood which agrees with the historical failure data for the study reaches.

  8. Hepatitis C virus inhibitor synergism suggests multistep interactions between heat-shock protein 90 and hepatitis C virus replication

    Science.gov (United States)

    Kubota, Naoko; Nomoto, Masataka; Hwang, Gi-Wook; Watanabe, Toshihiko; Kohara, Michinori; Wakita, Takaji; Naganuma, Akira; Kuge, Shusuke

    2016-01-01

    AIM: To address the effect of heat-shock protein 90 (HSP90) inhibitors on the release of the hepatitis C virus (HCV), a cell culture-derived HCV (JFH1/HCVcc) from Huh-7 cells was examined. METHODS: We quantified both the intracellular and extracellular (culture medium) levels of the components (RNA and core) of JFH-1/HCVcc. The intracellular HCV RNA and core levels were determined after the JFH1/HCVcc-infected Huh-7 cells were treated with radicicol for 36 h. The extracellular HCV RNA and core protein levels were determined from the medium of the last 24 h of radicicol treatment. To determine the possible role of the HSP90 inhibitor in HCV release, we examined the effect of a combined application of low doses of the HSP90 inhibitor radicicol and the RNA replication inhibitors cyclosporin A (CsA) or interferon. Finally, we statistically examined the combined effect of radicicol and CsA using the combination index (CI) and graphical representation proposed by Chou and Talalay. RESULTS: We found that the HSP90 inhibitors had greater inhibitory effects on the HCV RNA and core protein levels measured in the medium than inside the cells. This inhibitory effect was observed in the presence of a low level of a known RNA replication inhibitor (CsA or interferon-α). Treating the cells with a combination of radicicol and cyclosporin A for 24 h resulted in significant synergy (CI < 1) that affected the release of both the viral RNA and the core protein. CONCLUSION: In addition to having an inhibitory effect on RNA replication, HSP90 inhibitors may interfere with an HCV replication step that occurs after the synthesis of viral RNA, such as assembly and release. PMID:26925202

  9. Wafer plane inspection for advanced reticle defects

    Science.gov (United States)

    Nagpal, Rajesh; Ghadiali, Firoz; Kim, Jun; Huang, Tracy; Pang, Song

    2008-05-01

    Readiness of new mask defect inspection technology is one of the key enablers for insertion & transition of the next generation technology from development into production. High volume production in mask shops and wafer fabs demands a reticle inspection system with superior sensitivity complemented by a low false defect rate to ensure fast turnaround of reticle repair and defect disposition (W. Chou et al 2007). Wafer Plane Inspection (WPI) is a novel approach to mask defect inspection, complementing the high resolution inspection capabilities of the TeraScanHR defect inspection system. WPI is accomplished by using the high resolution mask images to construct a physical mask model (D. Pettibone et al 1999). This mask model is then used to create the mask image in the wafer aerial plane. A threshold model is applied to enhance the inspectability of printing defects. WPI can eliminate the mask restrictions imposed on OPC solutions by inspection tool limitations in the past. Historically, minimum image restrictions were required to avoid nuisance inspection stops and/or subsequent loss of sensitivity to defects. WPI has the potential to eliminate these limitations by moving the mask defect inspections to the wafer plane. This paper outlines Wafer Plane Inspection technology, and explores the application of this technology to advanced reticle inspection. A total of twelve representative critical layers were inspected using WPI die-to-die mode. The results from scanning these advanced reticles have shown that applying WPI with a pixel size of 90nm (WPI P90) captures all the defects of interest (DOI) with low false defect detection rates. In validating CD predictions, the delta CDs from WPI are compared against Aerial Imaging Measurement System (AIMS), where a good correlation is established between WPI and AIMSTM.

  10. Accessing ns-μs side chain dynamics in ubiquitin with methyl RDCs

    International Nuclear Information System (INIS)

    Fares, Christophe; Lakomek, Nils-Alexander; Walter, Korvin F. A.; Frank, Benedikt T. C.; Meiler, Jens; Becker, Stefan; Griesinger, Christian

    2009-01-01

    This study presents the first application of the model-free analysis (MFA) (Meiler in J Am Chem Soc 123:6098-6107, 2001; Lakomek in J Biomol NMR 34:101-115, 2006) to methyl group RDCs measured in 13 different alignment media in order to describe their supra-τ c dynamics in ubiquitin. Our results indicate that methyl groups vary from rigid to very mobile with good correlation to residue type, distance to backbone and solvent exposure, and that considerable additional dynamics are effective at rates slower than the correlation time τ c . In fact, the average amplitude of motion expressed in terms of order parameters S 2 associated with the supra-τ c window brings evidence to the existence of fluctuations contributing as much additional mobility as those already present in the faster ps-ns time scale measured from relaxation data. Comparison to previous results on ubiquitin demonstrates that the RDC-derived order parameters are dominated both by rotameric interconversions and faster libration-type motions around equilibrium positions. They match best with those derived from a combined J-coupling and residual dipolar coupling approach (Chou in J Am Chem Soc 125:8959-8966, 2003) taking backbone motion into account. In order to appreciate the dynamic scale of side chains over the entire protein, the methyl group order parameters are compared to existing dynamic ensembles of ubiquitin. Of those recently published, the broadest one, namely the EROS ensemble (Lange in Science 320:1471-1475, 2008), fits the collection of methyl group order parameters presented here best. Last, we used the MFA-derived averaged spherical harmonics to perform highly-parameterized rotameric searches of the side chains conformation and find expanded rotamer distributions with excellent fit to our data. These rotamer distributions suggest the presence of concerted motions along the side chains

  11. Cetuximab-conjugated iron oxide nanoparticles for cancer imaging and therapy

    Directory of Open Access Journals (Sweden)

    Tseng SH

    2015-05-01

    Full Text Available Shih-Heng Tseng,1,2 Min-Yuan Chou,2 I-Ming Chu1 1Department of Chemical Engineering, National Tsing Hua University, 2Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan Abstract: We have developed a theranostic nanoparticle, ie, cet-PEG-dexSPIONs, by conjugation of the anti-epidermal growth factor receptor (EGFR monoclonal antibody, cetuximab, to dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs via periodate oxidation. Approximately 31 antibody molecules were conjugated to each nanoparticle. Cet-PEG-dexSPIONs specifically bind to EGFR-expressing tumor cells and enhance image contrast on magnetic resonance imaging. Cet-PEG-dexSPION-treated A431 cells showed significant inhibition of epidermal growth factor-induced EGFR phosphorylation and enhancement of EGFR internalization and degradation. In addition, a significant increase in apoptosis was detected in EGFR-overexpressing cell lines, A431 and 32D/EGFR, after 24 hours of incubation at 37°C with cet-PEG-dexSPIONs compared with cetuximab alone. The antibody-dependent cell-mediated cytotoxicity of cetuximab was observed in cet-PEG-dexSPIONs. The results demonstrated that cet-PEG-dexSPIONs retained the therapeutic effect of cetuximab in addition to having the ability to target and image EGFR-expressing tumors. Cet-PEG-dexSPIONs represent a promising targeted magnetic probe for early detection and treatment of EGFR-expressing tumor cells. Keywords: epidermal growth factor receptor, cetuximab, superparamagnetic iron oxide nanoparticle, magnetic resonance imaging, sodium periodate, polyethylene glycol

  12. Effectiveness of sensory processing strategies on activity level in inclusive preschool classrooms

    Directory of Open Access Journals (Sweden)

    Lin CL

    2012-10-01

    Full Text Available Chien-Lin Lin,1,2 Yu-Fan Min,3 Li-Wei Chou,1,2,* Chin-Kai Lin,4,* 1Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 2School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 3Faith, Hope and Love, Center for Children and Adults With Disabilities, Taichung, Taiwan; 4Program of Early Intervention, Department of Early Childhood Education, National Taichung University of Education, Taichung, Taiwan*These authors contributed equally to this workBackground: The purpose of this study was to investigate the effectiveness of sensory processing strategies in improving the activity level of children with sensory integration dysfunction.Methods: The study used a matching-only pretest–posttest control group design, which requires random matching of sensory integration dysfunction to the corresponding intervention group (n = 18 and control group (n = 18. The intervention group comprised 3–6-year-old children who received an 8-week school-day intervention during implementation of the theme curriculum.Results: The 8-week treatment significantly reduced the activity level and foot-swinging episodes in children with sensory integration dysfunction, and obtained a medium-effect size. However, the level of improvement in the control group did not show any statistically significant change.Conclusion: Sensory processing strategies could improve activity levels in children with sensory integration dysfunction. However, this study was unable to exclude a developmental effect. The social validity results show that sensory processing strategies can be integrated into the theme curriculum and improve activity levels in children.Keywords: activity level, preschool inclusive classroom, sensory integration dysfunction, sensory processing strategy

  13. Quantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells.

    Science.gov (United States)

    Khafif, A; Schantz, S P; Chou, T C; Edelstein, D; Sacks, P G

    1998-03-01

    An in vitro model for oral cancer was used to examine the growth inhibitory effects of chemopreventive agents when used singly and in combination. The model consists of primary cultures of normal oral epithelial cells, newly established cell lines derived from dysplastic leukoplakia and squamous cell carcinoma. Two naturally occurring substances, (-)-epigallocatechin-3-gallate (EGCG) from green tea and curcumin from the spice turmeric were tested. Cells were treated singly and in combination and effects on growth determined in 5-day growth assays and by cell cycle analysis. Effective dose 50s and the combination index were calculated with the computerized Chou-Talalay method which is based on the median-effect principle. Agents were shown to differ in their inhibitory potency. EGCG was less effective with cell progression; the cancer cells were more resistant than normal or dysplastic cells. In contrast, curcumin was equally effective regardless of the cell type tested. Cell cycle analysis indicated that EGCG blocked cells in G1, whereas curcumin blocked cells in S/G2M. The combination of both agents showed synergistic interactions in growth inhibition and increased sigmoidicity (steepness) of the dose-effect curves, a response that was dose and cell type dependent. Combinations allowed for a dose reduction of 4.4-8.5-fold for EGCG and 2.2-2.8-fold for curcumin at ED50s as indicated by the dose reduction index (DRI). Even greater DRI values were observed above ED50 levels. Our results demonstrate that this model which includes normal, premalignant and malignant oral cells can be used to analyse the relative potential of various chemopreventive agents. Two such naturally-occurring agents, EGCG and curcumin, were noted to inhibit growth by different mechanisms, a factor which may account for their demonstrable interactive synergistic effect.

  14. Predicting protein subnuclear location with optimized evidence-theoretic K-nearest classifier and pseudo amino acid composition

    International Nuclear Information System (INIS)

    Shen Hongbin; Chou Kuochen

    2005-01-01

    The nucleus is the brain of eukaryotic cells that guides the life processes of the cell by issuing key instructions. For in-depth understanding of the biochemical process of the nucleus, the knowledge of localization of nuclear proteins is very important. With the avalanche of protein sequences generated in the post-genomic era, it is highly desired to develop an automated method for fast annotating the subnuclear locations for numerous newly found nuclear protein sequences so as to be able to timely utilize them for basic research and drug discovery. In view of this, a novel approach is developed for predicting the protein subnuclear location. It is featured by introducing a powerful classifier, the optimized evidence-theoretic K-nearest classifier, and using the pseudo amino acid composition [K.C. Chou, PROTEINS: Structure, Function, and Genetics, 43 (2001) 246], which can incorporate a considerable amount of sequence-order effects, to represent protein samples. As a demonstration, identifications were performed for 370 nuclear proteins among the following 9 subnuclear locations: (1) Cajal body, (2) chromatin, (3) heterochromatin, (4) nuclear diffuse, (5) nuclear pore, (6) nuclear speckle, (7) nucleolus, (8) PcG body, and (9) PML body. The overall success rates thus obtained by both the re-substitution test and jackknife cross-validation test are significantly higher than those by existing classifiers on the same working dataset. It is anticipated that the powerful approach may also become a useful high throughput vehicle to bridge the huge gap occurring in the post-genomic era between the number of gene sequences in databases and the number of gene products that have been functionally characterized. The OET-KNN classifier will be available at www.pami.sjtu.edu.cn/people/hbshen

  15. A Nine-Year Follow-up Study of Sleep Patterns and Mortality in Community-Dwelling Older Adults in Taiwan

    Science.gov (United States)

    Chen, Hsi-Chung; Su, Tung-Ping; Chou, Pesus

    2013-01-01

    Study Objectives: To simultaneously explore the associations between mortality and insomnia, sleep duration, and the use of hypnotics in older adults. Design: A fixed cohort study. Setting: A community in Shih-Pai area, Taipei, Taiwan. Participants: A total of 4,064 participants over the age of 65 completed the study. Intervention: N/A. Measurements and Results: Insomnia was classified using an exclusionary hierarchical algorithm, which categorized insomnia as “no insomnia,” “subjective poor sleep quality,” “Pittsburgh Sleep Quality Index > 5 insomnia,” “1-month insomnia disorder,” and “6-month insomnia disorder.” The main outcome variables were 9-year all-cause mortality rates. In the all-cause mortality analyses, when hypnotic use, depressive symptoms and total sleep time were excluded from a proportional hazards regression model, subjects with “Pittsburgh Sleep Quality Index > 5 insomnia” had a higher mortality risk (HR: 1.21, 95% CI: 1.01-1.45). In the full model, frequent hypnotic use and long sleep duration predicted higher mortality rates. However, the increased mortality risk for subjects with “Pittsburgh Sleep Quality Index > 5 insomnia” was not observed in the full model. On the contrary, individuals with a 6-month DSM-IV insomnia disorder had a lower risk for premature death (HR: 0.64, 95% CI: 0.43-0.96). Conclusions: Long sleep duration and frequent hypnotics use predicted an increased mortality risk within a community-dwelling sample of older adults. The association between insomnia and mortality was affected by insomnia definition and other parameters related to sleep patterns. Citation: Chen HC; Su TP; Chou P. A nine-year follow-up study of sleep patterns and mortality in community-dwelling older adults in Taiwan. SLEEP 2013;36(8):1187-1198. PMID:23904679

  16. Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803.

    Science.gov (United States)

    Zhang, Xiu-Zhen; Wang, Ling; Liu, Dong-Wu; Tang, Guang-Yan; Zhang, Hong-Yu

    2014-09-01

    This study aims at evaluating the anticancer effects of berberine hydrochloride (berberine) and d-limonene, alone and in combination, on human gastric carcinoma cell line MGC803 to determine whether berberine and d-limonene work synergistically and elucidate their mechanisms. MGC803 cells were treated with berberine and d-limonene, alone and in combination, for 24-48 h. The inhibitory effects of these drugs on growth were determined by MTT assay. The combination index and drug reduction index were calculated with the Chou-Talalay method based on the median-effect principle. Flow cytometry and laser scanning confocal microscopy were employed to evaluate the effects of both drugs on cell-cycle perturbation and apoptosis, generation of reactive oxygen species (ROS), mitochondrial membrane potential, and expression of Bcl-2 and caspase-3 in MGC803 cells. Berberine or d-limonene alone can inhibit the growth of MGC803 cells in a dose- and time-dependent manner. Berberine and d-limonene at a combination ratio of 1:4 exhibited a synergistic effect on anti-MGC803 cells. The two drugs distinctly induced intracellular ROS generation, reduced the mitochondrial transmembrane potential (ΔΨm), enhanced the expression of caspase-3, and decreased the expression of Bcl-2. The combination of berberine and d-limonene showed more remarkable effects compared with drugs used singly in MGC803 cells. The combination of berberine and d-limonene exerted synergistic anticancer effects on MGC803 cells by cell-cycle arrest, ROS production, and apoptosis induction through the mitochondria-mediated intrinsic pathway.

  17. Healing of Achilles tendon partial tear following focused shockwave: a case report and literature review

    Directory of Open Access Journals (Sweden)

    Hsu YC

    2017-05-01

    Full Text Available Yu-Chun Hsu,1,* Wei-Ting Wu,2,* Ke-Vin Chang,2–4 Der-Sheng Han,2–4 Li-Wei Chou5–7 1Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, 2Department of Physical Medicine and Rehabilitation and Community and Geriatric Research Center, National Taiwan University Hospital, Bei-Hu Branch, 3National Taiwan University College of Medicine, 4Community and Geriatric Research Center, National Taiwan University Hospital, Bei-Hu Branch, Taipei, 5Department of Physical Medicine and Rehabilitation, China Medical University Hospital, 6Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, 7Department of Rehabilitation, Asia University Hospital, Taichung, Taiwan *These authors contributed equally to this work Abstract: Achilles tendinopathy is a common cause of posterior heel pain and can progress to partial tendon tear without adequate treatment. Effects of traditional treatments vary, and many recent reports focus on the use of extracorporeal shockwave therapy (ESWT for Achilles tendinopathy but not for Achilles tendon partial tear. Here, we report the case of a 64-year-old female suffering from severe left heel pain for half a year. All treatment and rehabilitation were less effective until ESWT was applied. Each course of focused shockwave therapy included 2500 shots with energy flux density from 0.142 mJ/mm2 to 0.341 mJ/mm2. The visual analog scale decreased from nine to one degree. High-resolution musculoskeletal ultrasonography was performed before and 1 month after the treatment, which revealed healing of the torn region and decrease in inflammation. ESWT had shown to be an alternative treatment for Achilles tendon partial tear under safety procedure and ultrasound observation. Keywords: focused shockwave, Achilles tendon, partial tear, ultrasonography

  18. Meteoritic Constraints on Models of the Solar Nebula: The Abundances of Moderately Volatile Elements

    Science.gov (United States)

    Cassen, Patrick; Cuzzi, Jeff (Technical Monitor)

    1994-01-01

    The "moderately volatile" elements are those which condense (or evaporate) in the temperature range 650 - 1350 K, as a mix of material with solar abundances is cooled (or heated) tinder equilibrium conditions. Their relative abundances in chondritic meteorites are solar (or "cosmic", as defined by the composition of Cl meteorites) to within a factor of several, but vary within that range in a way that correlates remarkably well with condensation temperature, independent of chemical affinity. It has been argued that this correlation reflects a systematically selective process which favored the accretion of refractory material over volatile material from a cooling nebula. Wasson and Chou (Meteoritics 9, 69-94, 1974, and Wasson and co-authors in subsequent papers) suggested that condensation and settling of solids contemporaneously with the cooling and removal of nebular gas could produce the observed abundance patterns, but a quantitative model has been lacking. We show that the abundance patterns of the moderately volatile elements in chondritic meteorites can be produced, in some degree of quantitative detail, by models of the solar nebula that are designed to conform to observations of T Tauri stars and the global conservation laws. For example, even if the local surface density of the nebula is not decreasing, condensation and accretion of solids from radially inflowing gas in a cooling nebula can result in depletions of volatiles, relative to refractories, like those observed, The details of the calculated abundance patterns depend on (but are not especially sensitive to) model parameters, and can exhibit the variations that distinguish the meteorite classes. Thus it appears that nebula characteristics such as cooling rates, radial flow velocities, and particle accumulation rates can be quantitatively constrained by demanding that they conform to meteoritic data; and the models, in turn, can produce testable hypotheses regarding the time and location of the

  19. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2011-12-01

    Full Text Available Esther Captain en Guno Jones, Oorlogserfgoed overzee: De erfenis van de Tweede Wereldoorlog in Aruba, Curaçao, Indonesië en Suriname (Fridus StijlenCynthia Chou, The Orang Suku Laut of Riau, Indonesia: The inalienable gift of territory (Timothy P. BarnardMarshall Clark, Maskulinitas: Culture, gender and politics inIndonesia (Will DerksMatthew Isaac Cohen, Performing otherness: Java and Bali on international stages, 1905-1952 (SuryadiMarleen Dieleman, Juliette Koning and Peter Post (eds, Chinese Indonesians and regime change (Dewi AnggraeniWim van den Doel, Zo ver de wereld strekt: De geschiedenis van Nederland overzee vanaf 1800 (Hans HägerdalMichael Feener and Terenjit Sevea (eds, Islamicconnections: Muslim societies in South and Southeast Asia (Michael LaffanR. Michael Feener, Muslim legal thought in Modern Indonesia (Stijn Cornelis van HuisZane Goebel, Language, migration, and identity: Neighbourhood talk in Indonesia (Sheri Lynn GibbingsLizzy van Leeuwen, Lost in mall: An ethnography of middle-class Jakarta in the 1990s (Andy FullerAlfred W. McCoy, Policing America’s empire: The United States, the Philippines, and the rise of the surveillance state (Florentino RodaoFrans H. Peters, Vervlogen verwachtingen: De teloorgang van Nieuw-Guinea in 1961-1962 (Jaap TimmerChristina Schwenkel, The American war in contemporary Vietnam: Transnational remembrance and representation (Hans HägerdalYeoh Seng Guan, Loh Wei Leng, Khoo Salma Nasution and Neil Khor, Penang and its region: The story of an Asian entrepôt (David Kloos

  20. Ovarian carcinoma glyco-antigen targeted by human IgM antibody.

    Directory of Open Access Journals (Sweden)

    Yi Chen

    Full Text Available Epithelial Ovarian Cancer (EOC cells expression of a novel carbohydrate antigen was defined using a human VH4-34 encoded IgM monoclonal antibody (mAb216. MAb216 binds to a poly N-acetyllactosamine epitope expressed on B cells and kills normal and malignant B cells in vitro and in vivo. EOC patient ascites and EOC cell lines were used to study the anti tumor effect of mAb216. Various assays were used to characterize the epitope and demonstrate antibody-mediated binding and cytotoxicity in EOC. Drug and antibody combination effects were determined by calculating the combination index values using the Chou and Talalay method. MAb216 displays direct antibody mediated cytotoxicity on a population of human EOC tumor and ascites samples and EOC cell lines, which express high amounts of poly N-acetyllactosamine epitope, carried by CD147/CD98. Eighty four percent of patient samples, including platin resistant, had a tumor population that bound the monoclonal antibody. The binding pattern of mAb216 and mechanism of cytotoxicity was similar to that seen on normal and malignant B cells with unique general membrane disruption and "pore" formation. In vitro incubation with mAb216 and cisplatin enhanced killing of OVCAR3 cell line. In EOC cell lines percent cytotoxicity correlated with percent expression of epitope. Although in vitro data shows specific EOC cytotoxicity, for possible treatment of EOC MAb216 would need to be evaluated in a clinical trial with or without chemotherapy.

  1. Protolichesterinic acid enhances doxorubicin-induced apoptosis in HeLa cells in vitro.

    Science.gov (United States)

    Brisdelli, Fabrizia; Perilli, Mariagrazia; Sellitri, Doriana; Bellio, Pierangelo; Bozzi, Argante; Amicosante, Gianfranco; Nicoletti, Marcello; Piovano, Marisa; Celenza, Giuseppe

    2016-08-01

    The aim of this study was to investigate the effect of protolichesterinic acid, a lichen secondary metabolite, on anti-proliferative activity of doxorubicin in three human cancer cell lines, HeLa, SH-SY5Y and K562 cells. The data obtained from MTT assays, performed on cells treated with protolichesterinic acid and doxorubicin alone and in combination, were analysed by the median-effect method as proposed by Chou and Talalay and the Bliss independence model. Apoptosis rate was evaluated by fluorescence microscopy, caspase-3, 8 and 9 activities were detected by spectrofluorimetric analysis and protein expression of Bim, Bid, Bax and Mcl-2 was analysed by Western blotting. The interaction of protolichesterinic acid with thioesterase domain of human fatty acid synthase (hFAS) was investigated by a molecular docking study. The in vitro activity of doxorubicin against HeLa cancer cell line, but not against SH-SY5Y and K562 cells, was synergically increased by protolichesterinic acid. The increased cytotoxicity caused by protolichesterinic acid in HeLa cells was due to a pro-apoptotic effect and was associated to caspase-3, 8 and 9 activation. The simultaneous treatment for 24h with protolichesterinic acid plus doxorubicin caused an increase of Bim protein expression and the appearance of cleaved form of Bid protein. The molecular modelling analysis showed that protolichesterinic acid seemed to behave as a competitive inhibitor of hFAS. These results suggest that protolichesterinic acid could be envisaged as an useful tool against certain types of tumor cells in combination with anticancer drugs. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. The development of 8 inch roll-to-plate nanoimprint lithography (8-R2P-NIL) system

    Science.gov (United States)

    Lee, Lai Seng; Mohamed, Khairudin; Ooi, Su Guan

    2017-07-01

    Growth in semiconductor and integrated circuit industry was observed in the past decennium of years for industrial technology which followed Moore's law. The line width of nanostructure to be exposed was influenced by the essential technology of photolithography. Thus, it is crucial to have a low cost and high throughput manufacturing process for nanostructures. Nanoimprint Lithography technique invented by Stephen Y. Chou was considered as major nanolithography process to be used in future integrated circuit and integrated optics. The drawbacks of high imprint pressure, high imprint temperature, air bubbles formation, resist sticking to mold and low throughput of thermal nanoimprint lithography on silicon wafer have yet to be solved. Thus, the objectives of this work is to develop a high throughput, low imprint force, room temperature UV assisted 8 inch roll to plate nanoimprint lithography system capable of imprinting nanostructures on 200 mm silicon wafer using roller imprint with flexible mold. A piece of resist spin coated silicon wafer was placed onto vacuum chuck drives forward by a stepper motor. A quartz roller wrapped with a piece of transparent flexible mold was used as imprint roller. The imprinted nanostructures were cured by 10 W, 365 nm UV LED which situated inside the quartz roller. Heat generated by UV LED was dissipated by micro heat pipe. The flexible mold detaches from imprinted nanostructures in a 'line peeling' pattern and imprint pressure was measured by ultra-thin force sensors. This system has imprinting speed capability ranging from 0.19 mm/s to 5.65 mm/s, equivalent to imprinting capability of 3 to 20 pieces of 8 inch wafers per hour. Speed synchronization between imprint roller and vacuum chuck was achieved by controlling pulse rate supplied to stepper motor which drive the vacuum chuck. The speed different ranging from 2 nm/s to 98 nm/s is achievable. Vacuum chuck height was controlled by stepper motor with displacement of 5 nm/step.

  3. Reactivation of estrogen receptor α by vorinostat sensitizes mesenchymal-like triple-negative breast cancer to aminoflavone, a ligand of the aryl hydrocarbon receptor.

    Science.gov (United States)

    Stark, Karri; Burger, Angelika; Wu, Jianmei; Shelton, Phillip; Polin, Lisa; Li, Jing

    2013-01-01

    Aminoflavone (AF) acts as a ligand of the aryl hydrocarbon receptor (AhR). Expression of estrogen receptor α (ERα) and AhR-mediated transcriptional induction of CYP1A1 can sensitize breast cancer cells to AF. The objective of this study was to investigate the combined antitumor effect of AF and the histone deacetylase inhibitor vorinostat for treating mesenchymal-like triple-negative breast cancer (TNBC) as well as the underlying mechanisms of such treatment. In vitro antiproliferative activity of AFP464 (AF prodrug) in breast cancer cell lines was evaluated by MTS assay. In vitro, the combined effect of AFP464 and vorinostat on cell proliferation was assessed by the Chou-Talalay method. In vivo, antitumor activity of AFP464, given alone and in combination with vorinostat, was studied using TNBC xenograft models. Knockdown of ERα was performed using specific, small-interfering RNA. Western blot, quantitative RT-PCR, immunofluorescence, and immunohistochemical staining were performed to study the mechanisms underlying the combined antitumor effect. Luminal and basal A subtype breast cancer cell lines were sensitive to AFP464, whereas basal B subtype or mesenchymal-like TNBC cells were resistant. Vorinostat sensitized mesenchymal-like TNBC MDA-MB-231 and Hs578T cells to AFP464. It also potentiated the antitumor activity of AFP464 in a xenograft model using MDA-MB-231 cells. In vitro and in vivo mechanistic studies suggested that vorinostat reactivated ERα expression and restored AhR-mediated transcriptional induction of CYP1A1. The response of breast cancer cells to AF or AFP464 was associated with their gene expression profile. Vorinostat sensitized mesenchymal-like TNBC to AF, at least in part, by reactivating ERα expression and restoring the responsiveness of AhR to AF.

  4. Psychopathological Processes Involved in Social Comparison, Depression, and Envy on Facebook

    Directory of Open Access Journals (Sweden)

    Aurel Pera

    2018-01-01

    Full Text Available Is Facebook utilization beneficial or detrimental for psychological well-being? I draw on outstanding research (e.g., Chou and Edge, 2012; Lin and Utz, 2015; Appel et al., 2016; Ehrenreich and Underwood, 2016; Vogel and Rose, 2016; Hu et al., 2017 to substantiate that examining other individuals’ positively presented material on Facebook may have detrimental consequences. Increasing comparisons on Facebook may generate feelings of envy, the latter being a significant process determining the effect of growing social comparison on psychological well-being. To date, there is an increasing body of literature investigating the psychological consequences of Facebook usage, the function of relationship closeness in producing the feelings of contentment and envy, the impacts of exposure to positive content on Facebook, the link between envy and depression on Facebook, and the function of tie strength in expecting the emotional results of browsing Facebook. I am specifically interested in how previous research explored the consequences of Facebook use on psychological outcomes, the moderating function of envy in the link between Facebook use and reduced affective wellbeing, the psychological results of non-interactive Facebook conduct, and the role of relationship closeness in anticipating user’s contentment and envy after inspecting a post. A synthesis of the extant literature suggests that inspecting other individuals’ positive news on Facebook brings about contentment through emotional contagion, whereas negative news causes discomfort as a consequence of mood contagion, the transmissible effect being more powerful when the news is associated with a strong tie. The outcomes of this research back the argument that self-confidence and dispositional envy are instrumental in producing Facebook envy. These findings highlight that the emotional results of browsing Facebook are considerably affected by the substance of the comment, the personal

  5. Psychopathological Processes Involved in Social Comparison, Depression, and Envy on Facebook.

    Science.gov (United States)

    Pera, Aurel

    2018-01-01

    Is Facebook utilization beneficial or detrimental for psychological well-being? I draw on outstanding research (e.g., Chou and Edge, 2012; Lin and Utz, 2015; Appel et al., 2016; Ehrenreich and Underwood, 2016; Vogel and Rose, 2016; Hu et al., 2017) to substantiate that examining other individuals' positively presented material on Facebook may have detrimental consequences. Increasing comparisons on Facebook may generate feelings of envy, the latter being a significant process determining the effect of growing social comparison on psychological well-being. To date, there is an increasing body of literature investigating the psychological consequences of Facebook usage, the function of relationship closeness in producing the feelings of contentment and envy, the impacts of exposure to positive content on Facebook, the link between envy and depression on Facebook, and the function of tie strength in expecting the emotional results of browsing Facebook. I am specifically interested in how previous research explored the consequences of Facebook use on psychological outcomes, the moderating function of envy in the link between Facebook use and reduced affective wellbeing, the psychological results of non-interactive Facebook conduct, and the role of relationship closeness in anticipating user's contentment and envy after inspecting a post. A synthesis of the extant literature suggests that inspecting other individuals' positive news on Facebook brings about contentment through emotional contagion, whereas negative news causes discomfort as a consequence of mood contagion, the transmissible effect being more powerful when the news is associated with a strong tie. The outcomes of this research back the argument that self-confidence and dispositional envy are instrumental in producing Facebook envy. These findings highlight that the emotional results of browsing Facebook are considerably affected by the substance of the comment, the personal attributes of the Facebook user

  6. A family-oriented treatment program for youths with ketamine abuse and their caregivers: a pilot study in Taiwan

    Directory of Open Access Journals (Sweden)

    Wang LJ

    2015-07-01

    Full Text Available Liang-Jen Wang,1 Shing-Fang Lu,1 Wen-Jiun Chou,1 Mian-Yoon Chong,2 Yao-Hsing Wang,1 Yu-Lian Hsieh,1 Yi-Hsuan Lee,1 Ching Chen2 1Department of Child and Adolescent Psychiatry, 2Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Objective: The abuse of ketamine by youths has grown into a serious public health issue. However, a reliable and efficient treatment has still not been found for youths who abuse ketamine. This pilot study investigated the effects of a family-oriented treatment program for ketamine-using youths and their caregivers.Methods: To carry out this study, 42 youths with ketamine use (mean age 16.6±1.1 years who were referred to take part in a 10-week treatment program based on motivational enhancement principles were selected, as were their principal caregivers (mean age 46.4±7.1 years, who were similarly referred to take part in a 10-week training program for parenting skills. The study had the youths complete the Chinese Craving Beliefs Questionnaire, the Adolescents’ Behavior problem Scale, and the Family APGAR both immediately before and after the program. Likewise, the youths’ caregivers completed the Family APGAR, the 12-item version of the Chinese Health Questionnaire, and the Parenting Stress Index.Results: Of the 42 youth–caregiver pairs that took part in this study, 37 (88% completed the 10-week program and both sets of assessments. After the treatment, the participating youths’ substance cravings declined (t=3.88, P<0.001, while family function, as perceived by the participating caregivers, significantly increased (t=2.22, P=0.033. The improvement in caregivers’ perceptions of family function were positively related to the improvement of the caregivers’ health status (r=-0.36, P=0.022.Conclusion: According to its results, this pilot study submits that family-oriented treatment programs may be considered a potentially effective

  7. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2005-01-01

    Full Text Available Peter Borschberg (ed., Iberians in the Singapore-Melaka area and adjacent regions (16th to 18th century (Syed Muhd Khairudin Aljunied Katharine L. Wiegele, Investing in miracles; El Shaddai and the transformation of popular Catholicism in the Philippines (Greg Bankoff Jean Gelman Taylor, Indonesia; Peoples and histories (Peter Boomgaard Clive Moore, New Guinea; Crossing boundaries and history (Harold Brookfield Nathan Porath, When the bird flies; Shamanic therapy and the maintenance of worldly boundaries among an indigenous people of Riau (Sumatra (Cynthia Chou and Martin Platt Paul van der Grijp, Identity and development; Tongan culture, agriculture, and the perenniality of the gift (H.J.M. Claessen Tim Bunnell, Malaysia, modernity and the multimedia super corridor; A critical geography of intelligent landscapes (Ben Derudder L. Fontijne, Guardians of the land in Kelimado; Louis Fontijne’s study of a colonial district in eastern Indonesia (Maribeth Erb Karl-Heinz Golzio, Geschichte Kambodschas; Das Land der Khmer von Angkor bis zur Gegenwart (Volker Grabowsky Emmanuel Poisson, Mandarins et subalternes au nord du Viêt Nam; Une bureaucracie à l’épreuve (1820-1918 (Martin Grossheim Generale Missiven van Gouverneurs-Generaal en Raden aan Heren XVII der Verenigde Oostindische Compagnie, Volume 10, 1737-1743 (Gerrit Knaap Aris Ananta and Evi Nurvidya Arifin (eds, International migration in Southeast Asia (Santo Koesoebjono Vladimir Braginsky, The comparative study of traditional Asian literatures; From reflective traditionalism to neo-traditionalism (G.L. Koster Fiona Kerlogue (ed., Performing objects; Museums, material culture and performance in Southeast Asia (Jennifer Lindsay Th.C. van der Meij, Puspakrema; A Javanese romance from Lombok (Julian Millie Robyn Maxwell, Sari to sarong; Five hundred years of Indian and Indonesian textile exchange -- Jasleen Dhamija, Woven magic; The affinity between

  8. Synergistic activity of troxacitabine (Troxatyl™ and gemcitabine in pancreatic cancer

    Directory of Open Access Journals (Sweden)

    Leblond Lorraine

    2007-07-01

    Full Text Available Abstract Background Gemcitabine, a deoxycytidine nucleoside analog, is the current standard chemotherapy used as first-line treatment for patients with locally advanced or metastatic cancer of the pancreas, and extends life survival by 5.7 months. Advanced pancreatic cancer thus remains a highly unmet medical need and new therapeutic agents are required for this patient population. Troxacitabine (Troxatyl™ is the first unnatural L-nucleoside analog to show potent preclinical antitumor activity and is currently under clinical investigation. Troxacitabine was recently evaluated as a first-line therapy in 54 patients with advanced adenocarcinoma of the pancreas and gave comparable overall results to those reported with gemcitabine in recently published randomized trials. Methods The human pancreatic adenocarcinoma cell lines, AsPC-1, Capan-2, MIA PaCa-2 and Panc-1, were exposed to troxacitabine or gemcitabine alone or in combination, for 72 h, and the effects on cell growth were determined by electronic particle counting. Synergistic efficacy was determined by the isobologram and combination-index methods of Chou and Talalay. Mechanistic studies addressed incorporation of troxacitabine into DNA and intracellular levels of troxacitabine and gemcitabine metabolites. For in vivo studies, we evaluated the effect of both drugs, alone and in combination, on the growth of established human pancreatic (AsPC-1 tumors implanted subcutaneously in nude mice. Statistical analysis was calculated by a one-way ANOVA with Dunnett as a post-test and the two-tailed unpaired t test using GraphPad prism software. Results Synergy, evaluated using the CalcuSyn Software, was observed in all four cell-lines at multiple drug concentrations resulting in combination indices under 0.7 at Fa of 0.5 (50% reduction of cell growth. The effects of drug exposures on troxacitabine and gemcitabine nucleotide pools were analyzed, and although gemcitabine reduced phosphorylation of

  9. Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer

    International Nuclear Information System (INIS)

    Damaraju, Vijaya L; Bouffard, David Y; Wong, Clarence KW; Clarke, Marilyn L; Mackey, John R; Leblond, Lorraine; Cass, Carol E; Grey, Mike; Gourdeau, Henriette

    2007-01-01

    Gemcitabine, a deoxycytidine nucleoside analog, is the current standard chemotherapy used as first-line treatment for patients with locally advanced or metastatic cancer of the pancreas, and extends life survival by 5.7 months. Advanced pancreatic cancer thus remains a highly unmet medical need and new therapeutic agents are required for this patient population. Troxacitabine (Troxatyl™) is the first unnatural L-nucleoside analog to show potent preclinical antitumor activity and is currently under clinical investigation. Troxacitabine was recently evaluated as a first-line therapy in 54 patients with advanced adenocarcinoma of the pancreas and gave comparable overall results to those reported with gemcitabine in recently published randomized trials. The human pancreatic adenocarcinoma cell lines, AsPC-1, Capan-2, MIA PaCa-2 and Panc-1, were exposed to troxacitabine or gemcitabine alone or in combination, for 72 h, and the effects on cell growth were determined by electronic particle counting. Synergistic efficacy was determined by the isobologram and combination-index methods of Chou and Talalay. Mechanistic studies addressed incorporation of troxacitabine into DNA and intracellular levels of troxacitabine and gemcitabine metabolites. For in vivo studies, we evaluated the effect of both drugs, alone and in combination, on the growth of established human pancreatic (AsPC-1) tumors implanted subcutaneously in nude mice. Statistical analysis was calculated by a one-way ANOVA with Dunnett as a post-test and the two-tailed unpaired t test using GraphPad prism software. Synergy, evaluated using the CalcuSyn Software, was observed in all four cell-lines at multiple drug concentrations resulting in combination indices under 0.7 at Fa of 0.5 (50% reduction of cell growth). The effects of drug exposures on troxacitabine and gemcitabine nucleotide pools were analyzed, and although gemcitabine reduced phosphorylation of troxacitabine when cells were exposed at equal drug

  10. The Use of Benzodiazepine Receptor Agonists and Risk of Respiratory Failure in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Case-Control Study

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    Chen, Su-Jung; Yeh, Chiu-Mei; Chao, Tze-Fan; Liu, Chia-Jen; Wang, Kang-Ling; Chen, Tzeng-Ji; Chou, Pesus; Wang, Fu-Der

    2015-01-01

    Study Objectives: Insomnia is prevalent in patients with chronic obstructive pulmonary disease (COPD), and benzodiazepine receptor agonists (BZRAs) are the most commonly used drugs despite their adverse effects on respiratory function. The aim of this study was to investigate whether the use of BZRAs was associated with an increased risk of respiratory failure (RF) in COPD patients. Design: Matched case-control study. Setting: National Health Insurance Research Database (NHIRD) in Taiwan. Participants: The case group consisted of 2,434 COPD patients with RF, and the control group consisted of 2,434 COPD patients without RF, matched for age, sex, and date of enrollment. Measurements and Results: Exposure to BZRAs during the 180-day period preceding the index date was analyzed and compared in the case and control groups. Conditional logistic regression was performed, and the use of BZRAs was associated with an increased risk of RF (adjusted odds ratio [aOR] 1.56, 95% confidence interval [CI] 1.14–2.13). In subgroup analysis, we found that the benzodiazepine (BZD) users had a higher risk of RF (aOR 1.58, 95% CI 1.14–2.20), whereas the risk in non-benzodiazepine (non-BZD) users was insignificant (aOR 0.85, 95% CI 0.51–1.44). A greater than 2-fold increase in risk was found in those who received two or more kinds of BZRAs and those using a combination of BZD and non-BZD medications. Conclusions: The use of benzodiazepine receptor agonists was a significant risk factor for respiratory failure in patients with chronic obstructive pulmonary disease (COPD). Compared to benzodiazepine, the prescription of non-benzodiazepine may be safer for the management of insomnia in COPD patients. Citation: Chen SJ, Yeh CM, Chao TF, Liu CJ, Wang KL, Chen TJ, Chou P, Wang FD. The use of benzodiazepine receptor agonists and risk of respiratory failure in patients with chronic obstructive pulmonary disease: a nationwide population-based case-control study. SLEEP 2015;38(7):1045–1050

  11. Adjunct effect of music therapy on cognition in Alzheimer’s disease in Taiwan: a pilot study

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    Li CH

    2015-02-01

    Full Text Available Chien-Hsun Li,1–3 Ching-Kuan Liu,2,3 Yuan-Han Yang,2–4 Mei-Chuan Chou,2,4 Chun-Hung Chen,2 Chiou-Lian Lai2,3 1Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 3Department of and Master’s Program in Neurology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 4Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan Purpose: Music therapy (MT reviews have found beneficial effects on behaviors and social interaction in Alzheimer’s disease (AD but inconsistent effects on cognition. The purpose of the study was to evaluate the adjunct effect of long-term and home-based MT in AD patients under pharmacological treatment. Patients and methods: Mild AD cases (clinical dementia rating =0.5~1 were consecutively recruited and voluntarily separated into an MT group or control group (CG for 6 months. Outcome assessments included Cognitive Abilities Screening Instrument (CASI, CASI-estimated mini-mental state examination, clinical dementia rating with sum of box scores, and neuropsychiatric inventory. The MT interventions were Mozart’s Sonata (KV 448 and Pachelbel’s Canon, listening with headphones for 30 minutes daily in the morning and before sleep, respectively. Results: Forty-one cases (MT versus CG number =20 versus 21 were analyzed. Adjusted differences of CASI-estimated mini-mental state examination and CASI after 6 months in the MT group were slightly less decreased than the CG without statistical significance. In further analysis of cognitive domains of CASI, the adjusted difference of abstraction domain in the MT group was significantly better than the CG. Conclusion: Although there were no apparent additional benefits of this MT on the global cognition and daily functioning in mild AD patients, it confirms the adjunct

  12. Evolution in Intensity and Frequency of Extreme Events of Precipitation in Northeast Region and Brazilian Amazon in XXI Century

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    Fonseca, P. M.; Veiga, J. A.; Correia, F. S.; Brito, A. L.

    2013-05-01

    The aim of this research was evaluate changes in frequency and intensity of extreme events of precipitation in Brazilian Amazon and Northeast Region, doubling CO2 concentration in agreement of IPCC A2 emissions scenarios (Nakicenovic et al., 2001). For this evaluation was used ETA model (Chou et al., 2011), forced with CCSM3 Global model data (Meehl, 2006) to run 4 experiments, only for January, February and March: 1980-1990, 2000-2010, 2040-2050 and 2090-2100. Using the first decade as reference (1980-1990), was evaluated changes occurred in following decades, with a methodology to classify extremes events adapted from Frich (2002) and Gao (2006). Higher was the class, more intense is the event. An increase of 25% was observed in total precipitation in Brazilian Amazon for the end of XXI century and 12% for extreme events type 1, 9% for events type 2 and 10% for type 3. By the other hand, a 17% decrease of precipitation in Brazilian Northeast was observed, and a pronounced decay of 24% and 15% in extreme events contribution type 1 and 2 to total amount of precipitation, respectively. The difference between total normal type events was positive in this three decades compared with reference decade 1980-1990, varying positively from 4 to 6 thousand events included in normality by decade, these events was decreased in your majority of Class 1 events, which presented a decay of at least 3.500 events by each decade. This suggests an intensification of extreme events, considering that the amount of precipitation by class increased, and the number of events by class decreased. To Northeast region, an increasing in 9% of contribution to events type 3 class was observed, as well as in the frequency of this type of events (about of 700 more events). Major decreasing in number of classes extreme events occur in 2000-2010, to classes 1 and 3, with 7,2 and 5,6%, and by the end of century in class 3, with 4,5%. For the three analyzed decades a total decrease of 8.400 events was

  13. Entre conservation et développement : les évolutions récentes de la politique européenne des pêches dans les régions ultrapériphériques de la Caraïbe Between conservation and development: recent developments in European fisheries policy in the outermost regions of the Caribbean

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    Pierre Angelelli

    2012-05-01

    Full Text Available L’Union Européenne opère actuellement la seconde révision de sa politique de la pêche depuis la création de celle-ci, en 1970. Instituée pour développer la pêche maritime et garantir un revenu aux pêcheurs, la politique commune de la pêche (PCP s’est orientée progressivement vers la protection des espèces et de l’environnement marin. Pour cela, elle a sacrifié une part importante du secteur productif, mais a échoué et, avec le déclin de la pêche en Europe, les régions ultrapériphériques de la Caraïbe (RUP-C ont gagné en importance relative dans ce domaine. Elles représentent aujourd’hui près de 30% de la flotte nationale et les fondements malthusiens de la PCP ne sont plus adaptés à leurs caractéristiques : ressources halieutiques, développement économique, emplois, sécurité des approvisionnements alimentaires, etc. La réforme actuellement en cours, qui devrait aboutir avant 2012, offre peut-être une alternative aux RUP-C permettant la mise en œuvre des mesures spécifiques en application de l’article 349 du Traité sur le Fonctionnement de l’Union Européenne.The European Union currently operates the second reform of its Common Fisheries Policy since its creation in 1970. Established to develop the fisheries and provide incomes for fishermen, the Common Fisheries Policy (CFP was directed gradually towards the protection of the species and the marine environment.To do this, it sacrificed a large part of the productive sector, but failed, and with the decline of fisheries in Europe, the outermost regions of the Caribbean gained relative importance in this field. They now account for nearly 30% of the national fleet and the Malthusians bases of the CFP are not suited any more to their characteristics: fisheries resources, economic development, jobs, security of food supply, etc. The ongoing reform, which should be in force before 2012, may offer an alternative to the outermost regions of the Caribbean

  14. Theory of synergistic effects: Hill-type response surfaces as 'null-interaction' models for mixtures.

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    Schindler, Michael

    2017-08-02

    The classification of effects caused by mixtures of agents as synergistic, antagonistic or additive depends critically on the reference model of 'null interaction'. Two main approaches are currently in use, the Additive Dose (ADM) or concentration addition (CA) and the Multiplicative Survival (MSM) or independent action (IA) models. We compare several response surface models to a newly developed Hill response surface, obtained by solving a logistic partial differential equation (PDE). Assuming that a mixture of chemicals with individual Hill-type dose-response curves can be described by an n-dimensional logistic function, Hill's differential equation for pure agents is replaced by a PDE for mixtures whose solution provides Hill surfaces as 'null-interaction' models and relies neither on Bliss independence or Loewe additivity nor uses Chou's unified general theory. An n-dimensional logistic PDE decribing the Hill-type response of n-component mixtures is solved. Appropriate boundary conditions ensure the correct asymptotic behaviour. Mathematica 11 (Wolfram, Mathematica Version 11.0, 2016) is used for the mathematics and graphics presented in this article. The Hill response surface ansatz can be applied to mixtures of compounds with arbitrary Hill parameters. Restrictions which are required when deriving analytical expressions for response surfaces from other principles, are unnecessary. Many approaches based on Loewe additivity turn out be special cases of the Hill approach whose increased flexibility permits a better description of 'null-effect' responses. Missing sham-compliance of Bliss IA, known as Colby's model in agrochemistry, leads to incompatibility with the Hill surface ansatz. Examples of binary and ternary mixtures illustrate the differences between the approaches. For Hill-slopes close to one and doses below the half-maximum effect doses MSM (Colby, Bliss, Finney, Abbott) predicts synergistic effects where the Hill model indicates 'null

  15. The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells.

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    Lotte M E Berghauser Pont

    Full Text Available A phase I/II trial for glioblastoma with the oncolytic adenovirus Delta24-RGD was recently completed. Delta24-RGD conditionally replicates in cells with a disrupted retinoblastoma-pathway and enters cells via αvβ3/5 integrins. Glioblastomas are differentially sensitive to Delta24-RGD. HDAC inhibitors (HDACi affect integrins and share common cell death pathways with Delta24-RGD. We studied the combination treatment effects of HDACi and Delta24-RGD in patient-derived glioblastoma stem-like cells (GSC, and we determined the most effective HDACi.SAHA, Valproic Acid, Scriptaid, MS275 and LBH589 were combined with Delta24-RGD in fourteen distinct GSCs. Synergy was determined by Chou Talalay method. Viral infection and replication were assessed using luciferase and GFP encoding vectors and hexon-titration assays. Coxsackie adenovirus receptor and αvβ3 integrin levels were determined by flow cytometry. Oncolysis and mechanisms of cell death were studied by viability, caspase-3/7, LDH and LC3B/p62, phospho-p70S6K. Toxicity was studied on normal human astrocytes. MGMT promotor methylation status, TCGA classification, Rb-pathway and integrin gene expression levels were assessed as markers of responsiveness.Scriptaid and LBH589 acted synergistically with Delta24-RGD in approximately 50% of the GSCs. Both drugs moderately increased αvβ3 integrin levels and viral infection in responding but not in non-responding GSCs. LBH589 moderately increased late viral gene expression, however, virus titration revealed diminished viral progeny production by both HDACi, Scriptaid augmented caspase-3/7 activity, LC3B conversion, p62 and phospho-p70S6K consumption, as well as LDH levels. LBH589 increased LDH and phospho-p70S6K consumption. Responsiveness correlated with expression of various Rb-pathway genes and integrins. Combination treatments induced limited toxicity to human astrocytes.LBH589 and Scriptaid combined with Delta24-RGD revealed synergistic anti

  16. Ultrasound sonication with microbubbles disrupts blood vessels and enhances tumor treatments of anticancer nanodrug

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    Lin CY

    2012-04-01

    Full Text Available Chung-Yin Lin1*, Hsiao-Ching Tseng1*, Heng-Ruei Shiu1, Ming-Fang Wu2, Cheng-Ying Chou3, Win-Li Lin1,41Institute of Biomedical Engineering, 2Laboratory Animal Center, 3Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei, Taiwan; 4Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan*These authors contributed equally to this workAbstract: Ultrasound (US sonication with microbubbles (MBs has the potential to disrupt blood vessels and enhance the delivery of drugs into the sonicated tissues. In this study, mouse ear tumors were employed to investigate the therapeutic effects of US, MBs, and pegylated liposomal doxorubicin (PLD on tumors. Tumors started to receive treatments when they grew up to about 15 mm3 (early stage with injection of PLD 10 mg/kg, or up to 50 mm3 (medium stage with PLD 6 (or 4 mg/kg. Experiments included the control, PLD alone, PLD + MBs + US, US alone, and MBs + US groups. The procedure for the PLD + MBs + US group was that PLD was injected first, MB (SonoVue injection followed, and then US was immediately sonicated on the tumor. The results showed that: (1 US sonication with MBs was always able to produce a further hindrance to tumor growth for both early and medium-stage tumors; (2 for the medium-stage tumors, 6 mg/kg PLD alone was able to inhibit their growth, while it did not work for 4 mg/kg PLD alone; (3 with the application of MBs + US, 4 mg/kg PLD was able to inhibit the growth of medium-stage tumors; (4 for early stage tumors after the first treatment with a high dose of PLD alone (10 mg/kg, the tumor size still increased for several days and then decreased (a biphasic pattern; (5 MBs + US alone was able to hinder the growth of early stage tumors, but unable to hinder that of medium stage tumors. The results of histological examinations and blood perfusion measurements indicated that the application of MBs + US disrupts the tumor blood

  17. An interactive game-based shoulder wheel system for rehabilitation

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    Chou LW

    2012-11-01

    Full Text Available Chun-Ming Chang,1,* Yen-Ching Chang,2,3 Hsiao-Yun Chang,4 Li-Wei Chou5,6,* 1Department of Applied Informatics and Multimedia, Asia University, Taichung, Taiwan; 2Department of Medical Informatics, Chung Shan Medical University, Taichung, Taiwan; 3Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan; 4Department of Biotechnology, Asia University, Taichung, Taiwan; 5Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 6School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan*These authors contributed equally to this workBackground: Increases in the aging population and in the number of accidents have resulted in more people suffering from physical impairments or disabilities. Rehabilitation therapy thus attracts greater attention as a means of helping patients recover and return to a normal life. With the extremely long and tedious nature of traditional rehabilitation, patients are reluctant to continue the entire process, thus the expected effects of the therapy cannot be obtained. Games are well known to help patients improve their concentration and shift their attention away from the discomfort of their injuries during rehabilitation. Thus, incorporating game technology into a rehabilitation program may be a promising approach.Methods: In this study, a gaming system used for shoulder rehabilitation was developed. The mechanical parts and electric circuits were integrated to mimic the functionalities of a shoulder wheel. Several games were also designed to suit the rehabilitation needs of the patients based on the age and gender differences among the individual users, enabling individuals to undergo the rehabilitation process by playing games. Two surveys were conducted to evaluate the satisfaction of the participants regarding the gaming system.Results: The results of the online survey among a larger population

  18. People with low back pain perceive needs for non-biomedical services in workplace, financial, social and household domains: a systematic review

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    Louisa Chou

    2018-04-01

    Full Text Available Question: What needs of non-biomedical services are perceived by people with low back pain? Design: Systematic review of qualitative and quantitative studies examining perceived needs of non-biomedical services for low back pain, identified through searching of MEDLINE, EMBASE, CINAHL and PsycINFO (1990 to 2016. Participants: Adults with low back pain of any duration. Data extraction and analysis: Descriptive data regarding study design and methodology were extracted. The preferences, expectations and satisfaction with non-biomedical services reported by people with low back pain were identified and categorised within areas of perceived need. Results: Twenty studies (19 qualitative and one quantitative involving 522 unique participants (total pool of 590 were included in this systematic review. Four areas emerged. Workplace: people with low back pain experience pressure to return to work despite difficulties with the demands of their occupation. They want their employers to be informed about low back pain and they desire workplace accommodations. Financial: people with low back pain want financial support, but have concerns about the inefficiencies of compensation systems and the stigma associated with financial remuneration. Social: people with low back pain report feeling disconnected from social networks and want back-specific social support. Household: people with low back pain report difficulties with household duties; however, there are few data regarding their need for auxiliary devices and domestic help. Conclusion: People with low back pain identified work place, financial and social pressures, and difficulties with household duties as areas of need beyond their healthcare requirements that affect their ability to comply with management of their condition. Consideration of such needs may inform physiotherapists, the wider health system, social networks and the workplace to provide more relevant and effective services. [Chou L, Cicuttini

  19. Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro

    International Nuclear Information System (INIS)

    Trendowski, Matthew; Christen, Timothy D.; Acquafondata, Christopher; Fondy, Thomas P.

    2015-01-01

    Although the actin cytoskeleton is vital for carcinogenesis and subsequent pathology, no microfilament-directed agent has been approved for cancer chemotherapy. One of the most studied classes of microfilament-directed agents has been the cytochalasins, mycotoxins known to disrupt the formation of actin polymers. In the present study, we sought to determine the effects of cytochalasin congeners toward human drug sensitive and multidrug resistant cell lines. SKOV3 human ovarian carcinoma and several multidrug resistant derivatives were tested for sensitivity against a panel of nine cytochalasin congeners, as well as three clinically approved chemotherapeutic agents (doxorubicin, paclitaxel, and vinblastine). In addition, verapamil, a calcium ion channel blocker known to reverse P-glycoprotein (P-gp) mediated drug resistance, was used in combination with multiple cytochalasin congeners to determine whether drug sensitivity could be increased. While multidrug resistant SKVLB1 had increased drug tolerance (was more resistant) to most cytochalasin congeners in comparison to drug sensitive SKOV3, the level of resistance was 10 to 1000-fold less for the cytochalasins than for any of the clinically approved agents. While cytochalasins did not appear to alter the expression of ATP binding cassette (ABC) transporters, several cytochalasins appeared to inhibit the activity of ABC transporter-mediated efflux of rhodamine 123 (Rh123), suggesting that these congeners do have affinity for drug efflux pumps. Cytochalasins also appeared to significantly decrease the F/G-actin ratio in both drug sensitive and drug resistant cells, indicative of marked microfilament inhibition. The cytotoxicity of most cytochalasin congeners could be increased with the addition of verapamil, and the drug sensitivity of resistant SKVLB1 to the clinically approved antineoplastic agents could be increased with the addition of cytochalasins. As assessed by isobolographic analysis and Chou

  20. Psychopathological Processes Involved in Social Comparison, Depression, and Envy on Facebook

    Science.gov (United States)

    Pera, Aurel

    2018-01-01

    Is Facebook utilization beneficial or detrimental for psychological well-being? I draw on outstanding research (e.g., Chou and Edge, 2012; Lin and Utz, 2015; Appel et al., 2016; Ehrenreich and Underwood, 2016; Vogel and Rose, 2016; Hu et al., 2017) to substantiate that examining other individuals’ positively presented material on Facebook may have detrimental consequences. Increasing comparisons on Facebook may generate feelings of envy, the latter being a significant process determining the effect of growing social comparison on psychological well-being. To date, there is an increasing body of literature investigating the psychological consequences of Facebook usage, the function of relationship closeness in producing the feelings of contentment and envy, the impacts of exposure to positive content on Facebook, the link between envy and depression on Facebook, and the function of tie strength in expecting the emotional results of browsing Facebook. I am specifically interested in how previous research explored the consequences of Facebook use on psychological outcomes, the moderating function of envy in the link between Facebook use and reduced affective wellbeing, the psychological results of non-interactive Facebook conduct, and the role of relationship closeness in anticipating user’s contentment and envy after inspecting a post. A synthesis of the extant literature suggests that inspecting other individuals’ positive news on Facebook brings about contentment through emotional contagion, whereas negative news causes discomfort as a consequence of mood contagion, the transmissible effect being more powerful when the news is associated with a strong tie. The outcomes of this research back the argument that self-confidence and dispositional envy are instrumental in producing Facebook envy. These findings highlight that the emotional results of browsing Facebook are considerably affected by the substance of the comment, the personal attributes of the Facebook

  1. Response to dexamethasone is glucose-sensitive in multiple myeloma cell lines

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    Turturro Francesco

    2011-09-01

    Full Text Available Abstract Background Hyperglycemia is among the major side effects of dexamethasone (DEX. Glucose or glucocorticoid (GC regulates the expression of thioredoxin-interacting protein (TXNIP that controls the production of reactive oxygen species (ROS through the modulation of thioredoxin (TRX activity. Methods Multiple myeloma (MM cells were grown in 5 or 20 mM/L glucose with or without 25 μM DEX. Semiquantitative reverse transcription-PCR (RT-PCR was used to assess TXNIP RNA expression in response to glucose and DEX. ROS were detected by 5-6-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate (CM-H2DCFDA. TRX activity was assayed by the insulin disulfide-reducing assay. Proliferation was evaluated using CellTiter96 reagent with 490-nm absorbtion and used to calculate the DEX IC50 in 20 mM/L glucose using the Chou's dose effect equation. Results TXNIP RNA level responded to glucose or DEX with the same order of magnitude ARH77 > NCIH929 > U266B1 in these cells. MC/CAR cells were resistant to the regulation. ROS level increased concurrently with reduced TRX activity. Surprisingly glucose increased TRX activity in MC/CAR cells keeping ROS level low. DEX and glucose were lacking the expected additive effect on TXNIP RNA regulation when used concurrently in sensitive cells. ROS level was significantly lower when DEX was used in conditions of hyperglycemia in ARH77/NCIH9292 cells but not in U266B1 cells. Dex-IC50 increased 10-fold when the dose response effect of DEX was evaluated with glucose in ARH && and MC/Car cells Conclusions Our study shows for the first time that glucose or DEX regulates important components of ROS production through TXNIP modulation or direct interference with TRX activity in MM cells. We show that glucose modulates the activity of DEX through ROS regualtion in MM cells. A better understanding of these pathways may help in improving the efficacy and reducing the toxicity of DEX, a drug still highly used in the treatment of

  2. Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells.

    Science.gov (United States)

    Klimaszewska-Wisniewska, Anna; Halas-Wisniewska, Marta; Tadrowski, Tadeusz; Gagat, Maciej; Grzanka, Dariusz; Grzanka, Alina

    2016-01-01

    The use of the dietary polyphenols as chemosensitizing agents to enhance the efficacy of conventional cytostatic drugs has recently gained the attention of scientists and clinicians as a plausible approach for overcoming the limitations of chemotherapy (e.g. drug resistance and cytotoxicity). The aim of this study was to investigate whether a naturally occurring diet-based flavonoid, fisetin, at physiologically attainable concentrations, could act synergistically with clinically achievable doses of paclitaxel to produce growth inhibitory and/or pro-death effects on A549 non-small cell lung cancer cells, and if it does, what mechanisms might be involved. The drug-drug interactions were analyzed based on the combination index method of Chou and Talalay and the data from MTT assays. To provide some insights into the mechanism underlying the synergistic action of fisetin and paclitaxel, selected morphological, biochemical and molecular parameters were examined, including the morphology of cell nuclei and mitotic spindles, the pattern of LC3-II immunostaining, the formation of autophagic vacuoles at the electron and fluorescence microscopic level, the disruption of cell membrane asymmetry/integrity, cell cycle progression and the expression level of LC3-II, Bax, Bcl-2 and caspase-3 mRNA. Here, we reported the first experimental evidence for the existence of synergism between fisetin and paclitaxel in the in vitro model of non-small cell lung cancer. This synergism was, at least partially, ascribed to the induction of mitotic catastrophe. The switch from the cytoprotective autophagy to the autophagic cell death was also implicated in the mechanism of the synergistic action of fisetin and paclitaxel in the A549 cells. In addition, we revealed that the synergism between fisetin and paclitaxel was cell line-specific as well as that fisetin synergizes with arsenic trioxide, but not with mitoxantrone and methotrexate in the A549 cells. Our results provide rationale for

  3. Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells

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    Coffey Matthew C

    2009-07-01

    Full Text Available Abstract Background Reovirus type 3 Dearing strain (ReoT3D has an inherent propensity to preferentially infect and destroy cancer cells. The oncolytic activity of ReoT3D as a single agent has been demonstrated in vitro and in vivo against various cancers, including colon, pancreatic, ovarian and breast cancers. Its human safety and potential efficacy are currently being investigated in early clinical trials. In this study, we investigated the in vitro combination effects of ReoT3D and chemotherapeutic agents against human non-small cell lung cancer (NSCLC. Results ReoT3D alone exerted significant cytolytic activity in 7 of 9 NSCLC cell lines examined, with the 50% effective dose, defined as the initial virus dose to achieve 50% cell killing after 48 hours of infection, ranging from 1.46 ± 0.12 ~2.68 ± 0.25 (mean ± SD log10 pfu/cell. Chou-Talalay analysis of the combination of ReoT3D with cisplatin, gemcitabine, or vinblastine demonstrated strong synergistic effects on cell killing, but only in cell lines that were sensitive to these compounds. In contrast, the combination of ReoT3D and paclitaxel was invariably synergistic in all cell lines tested, regardless of their levels of sensitivity to either agent. Treatment of NSCLC cell lines with the ReoT3D-paclitaxel combination resulted in increased poly (ADP-ribose polymerase cleavage and caspase activity compared to single therapy, indicating enhanced apoptosis induction in dually treated NSCLC cells. NSCLC cells treated with the ReoT3D-paclitaxel combination showed increased proportions of mitotic and apoptotic cells, and a more pronounced level of caspase-3 activation was demonstrated in mitotically arrested cells. Conclusion These data suggest that the oncolytic activity of ReoT3D can be potentiated by taxanes and other chemotherapeutic agents, and that the ReoT3D-taxane combination most effectively achieves synergy through accelerated apoptosis triggered by prolonged mitotic arrest.

  4. Role of resilience and social support in alleviating depression in patients receiving maintenance hemodialysis

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    Liu YM

    2018-03-01

    Full Text Available Yueh-Min Liu,1 Hong-Jer Chang,2 Ru-Hwa Wang,3 Li-King Yang,4 Kuo-Cheng Lu,4 Yi-Chou Hou4 1Department of Nursing, Ching Kuo Institute of Management and Health, Taiwan; 2Graduate Institute of Long-Term Care, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan; 3Department of Nursing, Fu-Jen Catholic University, New Taipei City, Taiwan; 4Division of Nephrology, Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan Background: Patients who undergo hemodialysis encounter challenges including role changes, physical degeneration, and difficulty in performing activities of daily living (ADLs and self-care. These challenges deteriorate their physiological and psychosocial conditions, resulting in depression. High resilience (RES and social support can alleviate stress and depression. This study evaluated the importance of RES and social support in managing depression in elderly patients undergoing maintenance hemodialysis (HD. Patients and methods: In this descriptive, correlational study, 194 older patients undergoing HD were enrolled from the HD centers of three hospitals in northern Taiwan. The Barthel ADL Index, RES scale, Inventory of Socially Supportive Behavior, and Beck Depression Inventory-II were used. Hierarchical regression analysis was applied to evaluate the interaction of RES and social support with illness severity, demographics, and ADLs. Results: Of the total participants, 45.9% experienced depressive symptoms. Demographic analysis showed that men and those with high educational level and income and financial independence had less depression (p<0.01. Patients with a higher Barthel Index (n=103, RES scale (n=33, and social support (n=113 showed less depressive symptoms (p<0.01. We found a significant negative correlation between depressive symptoms and social support (r=-0.506, p<0.01 and RES (r=-0.743, p<0.01. Hierarchical regression analysis showed

  5. Effects of primary caregiver participation in vestibular rehabilitation for unilateral neglect patients with right hemispheric stroke: a randomized controlled trial

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    Dai CY

    2013-04-01

    Full Text Available Chin-Ying Dai,1,2 Yu-Hui Huang,3,4 Li-Wei Chou,5,6 Shiao-Chi Wu,7 Ray-Yau Wang,8 Li-Chan Lin9 1School of Nursing, National Yang Ming University, Taipei, Taiwan; 2Department of Nursing, Central Taiwan University of Science and Technology, Taichung, Taiwan; 3Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan; 4School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 5Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 6School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 7Institute of Health and Welfare Policy, National Yang-Ming University, Taipei, Taiwan; 8Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan; 9Institute of Clinical and Community Health Nursing, National Yang-Ming University, Taipei, Taiwan, Republic of China Introduction: The current study aims to investigate the effects of primary caregiver participation in vestibular rehabilitation (VR on improving the measures of neglect, activities of daily living (ADL, balance, and falls of unilateral neglect (UN patients. Methods: This study is a single-blind randomized controlled trial. Both experimental (n = 24 and control groups (n = 24 received conventional rehabilitation. The experimental group undertook VR for a month. During the first and second weeks, a registered nurse trained the experimental group in VR. The primary caregivers in the experimental group supervised and guided their patients in VR during the third and fourth weeks. The outcome measures were neglect, ADL, balance, and falls. Results: The two groups of UN patients showed a significant improvement in neglect, ADL, and balance over time. Based on the generalized estimating equations model, an interaction was observed between groups and times. Significant interactions were observed between the VR group

  6. Development of an in vitro chemo-radiation response assay for cervical carcinoma.

    Science.gov (United States)

    Monk, Bradley J; Burger, Robert A; Parker, Ricardo; Radany, Eric H; Redpath, Leslie; Fruehauf, John P

    2002-11-01

    To determine if synergistic effects of radiation (RT) and chemotherapy (chemo) on human cervical carcinoma cell lines and fresh tumor explants could be determined using an in vitro assay. In vitro radiation response was determined for 4 cell lines and 26 fresh tumor explants in an agar-based assay. Cells were exposed to increasing doses of RT with or without cisplatin (CDDP), carmustine (BCNU), buthionine sulfoximine (BSO), or paclitaxel (Tax). Cell suspensions were cultured for 5 days, with [(3)H]thymidine added on day 3 and proliferation was measured. Results were reported as the fraction of proliferation compared to control (FC). For each combination of irradiation and drug, synergy was tested using the Chou analysis, where a combination index (CI) value of >0.7 indicated cross-resistance. RT dose-dependent proliferation inhibition was observed for 2 of the 4 cell lines, and for all but 1 of the fresh specimens. Significant heterogeneity of tumor response to RT was seen. Four specimens that were 1 standard deviation below the median FC response after exposure to 300 cGy were classified as extremely radiation resistant. Twenty-one tumors were evaluated for synergistic response using the combination of chemo and RT with a median FC of 0.27 (+/-0.27) for 6.0 Gy of RT alone, 0.22 (+/-0.21) for CDDP alone, and 0.05 (+/-0.08) for the combination. A CI of 0.35 and an R value of 0.09 demonstrated synergy between chemo and RT without cross-resistance. Similar synergy without cross-resistance was found for RT in combination with BCNU, BSO, and TAX. Heterogeneous RT dose-response relationships in the in vitro assay were demonstrated. Explants were more sensitive to RT than cell lines. Unlike cell lines, fresh tumor cells consistently displayed synergy with RT and chemo. The synergy between RT and BSO suggests that glutathione depletion may enhance the effect of RT. The assay was feasible for examining fresh tumors and may be an important tool for studying RT or drug

  7. Pulsed radiofrequency treatment of articular branches of femoral and obturator nerves for chronic hip pain

    Directory of Open Access Journals (Sweden)

    Chye CL

    2015-03-01

    Full Text Available Cien-Leong Chye,1 Cheng-Loong Liang,1 Kang Lu,1 Ya-Wen Chen,2,3 Po-Chou Liliang1 1Department of Neurosurgery, E-Da Hospital, I-Shou University, 2Department of Nursing, I-Shou University, 3School of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan Purpose: Chronic hip pain is a common symptom experienced by many people. Often, surgery is not an option for patients with multiple comorbidities, and conventional drugs either have many side effects or are ineffective. Pulsed radiofrequency (PRF is a new method in the treatment of pain. We attempt to compare the efficacy of PRF relative to conservative management for chronic hip pain.Patients and methods: Between August 2011 and July 2013, 29 patients with chronic hip pain were divided into two groups (PRF and conservative treatment according to consent or refusal to undergo PRF procedure. Fifteen patients received PRF of the articular branches of the femoral and obturator nerves, and 14 patients received conservative treatment. Visual analog scale (VAS, Oxford hip scores (OHS, and pain medications were used for outcome measurement before treatment and at 1 week, 4 weeks, and 12 weeks after treatment.Results: At 1 week, 4 weeks, and 12 weeks after treatment initiation, improvements in VAS were significantly greater with PRF. Improvements in OHS were significantly greater in the PRF group at 1 week, 4 weeks, and 12 weeks. Patients in the PRF group also used less pain medications. Eight subjects in the conservative treatment group switched to the PRF group after 12 weeks, and six of them had >50% improvement.Conclusion: When compared with conservative treatment, PRF of the articular branches of the femoral and obturator nerves offers greater pain relief for chronic hip pain and can augment physical functioning. Keywords: pulsed radiofrequency, obturator and femoral nerves, hip joint pain, osteoar­thritis

  8. Infrastructure sufficiency in meeting water demand under climate-induced socio-hydrological transition in the urbanizing Capibaribe River basin - Brazil

    Science.gov (United States)

    Ribeiro Neto, A.; Scott, C. A.; Lima, E. A.; Montenegro, S. M. G. L.; Cirilo, J. A.

    2014-09-01

    Water availability for a range of human uses will increasingly be affected by climate change, especially in the arid and semiarid tropics. The main objective of this study is to evaluate the infrastructure sufficiency in meeting water demand under climate-induced socio-hydrological transition in the Capibaribe River basin (CRB). The basin has experienced spatial and sectoral (agriculture-to-urban) reconfiguration of water demands. Human settlements that were once dispersed, relying on intermittent sources of surface water, are now larger and more spatially concentrated, which increases water-scarcity effects. Based on the application of linked hydrologic and water-resources models using precipitation and temperature projections of the IPCC SRES (Special Report: Emissions Scenarios) A1B scenario, a reduction in rainfall of 26.0% translated to streamflow reduction of 60.0%. We used simulations from four members of the HadCM3 (UK Met Office Hadley Centre) perturbed physics ensemble, in which a single model structure is used and perturbations are introduced to the physical parameterization schemes in the model (Chou et al., 2012). We considered that the change of the water availability in the basin in the future scenarios must drive the water management and the development of adaptation strategies that will manage the water demand. Several adaptive responses are considered, including water-loss reductions, wastewater collection and reuse, and rainwater collection cisterns, which together have potential to reduce future water demand by 23.0%. This study demonstrates the vulnerabilities of the infrastructure system during socio-hydrological transition in response to hydroclimatic and demand variabilities in the CRB and also indicates the differential spatial impacts and vulnerability of multiple uses of water to changes over time. The simulations showed that the measures proposed and the water from interbasin transfer project of the São Francisco River had a positive

  9. People with low back pain perceive needs for non-biomedical services in workplace, financial, social and household domains: a systematic review.

    Science.gov (United States)

    Chou, Louisa; Cicuttini, Flavia M; Urquhart, Donna M; Anthony, Shane N; Sullivan, Kaye; Seneviwickrama, Maheeka; Briggs, Andrew M; Wluka, Anita E

    2018-04-01

    What needs of non-biomedical services are perceived by people with low back pain? Systematic review of qualitative and quantitative studies examining perceived needs of non-biomedical services for low back pain, identified through searching of MEDLINE, EMBASE, CINAHL and PsycINFO (1990 to 2016). Adults with low back pain of any duration. Descriptive data regarding study design and methodology were extracted. The preferences, expectations and satisfaction with non-biomedical services reported by people with low back pain were identified and categorised within areas of perceived need. Twenty studies (19 qualitative and one quantitative) involving 522 unique participants (total pool of 590) were included in this systematic review. Four areas emerged. Workplace: people with low back pain experience pressure to return to work despite difficulties with the demands of their occupation. They want their employers to be informed about low back pain and they desire workplace accommodations. Financial: people with low back pain want financial support, but have concerns about the inefficiencies of compensation systems and the stigma associated with financial remuneration. Social: people with low back pain report feeling disconnected from social networks and want back-specific social support. Household: people with low back pain report difficulties with household duties; however, there are few data regarding their need for auxiliary devices and domestic help. People with low back pain identified work place, financial and social pressures, and difficulties with household duties as areas of need beyond their healthcare requirements that affect their ability to comply with management of their condition. Consideration of such needs may inform physiotherapists, the wider health system, social networks and the workplace to provide more relevant and effective services. [Chou L, Cicuttini FM, Urquhart DM, Anthony SN, Sullivan K, Seneviwickrama M, Briggs AM, Wluka AE (2018) People with

  10. Dilemma of prescribing aripiprazole under the Taiwan health insurance program: a descriptive study

    Directory of Open Access Journals (Sweden)

    Hsu YC

    2015-01-01

    Full Text Available Yi-Chien Hsu,1,2 Yu-Ching Chou,3 Hsin-An Chang,1,2,4 Yu-Chen Kao,1,2,5 San-Yuan Huang,1,2 Nian-Sheng Tzeng1,2,4 1Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan; 2School of Medicine, 3School of Public Health, 4Student Counseling Center, National Defense Medical Center, Taipei, Taiwan; 5Department of Psychiatry, Tri-Service General Hospital, Song-Shan Branch, Taipei, Taiwan Objectives: Refractory major depressive disorder (MDD is a serious problem leading to a heavy economic burden. Antipsychotic augmentation treatment with aripiprazole and quetiapine is approved for MDD patients and can achieve a high remission rate. This study aimed to examine how psychiatrists in Taiwan choose medications and how that choice is influenced by health insurance payments and administrative policy.Design: Descriptive study.Outcome measures: Eight questions about the choice of treatment strategy and atypical antipsychotics, and the reason to choose aripiprazole.Intervention: We designed an augmentation strategy questionnaire for psychiatrists whose patients had a poor response to antidepressants, and handed it out during the annual meeting of the Taiwanese Society of Psychiatry in October 2012. It included eight questions addressing the choice of treatment strategy and atypical antipsychotics, and the reason whether or not to choose aripiprazole as the augmentation antipsychotic.Results: Choosing antipsychotic augmentation therapy or switching to other antidepressant strategies for MDD patients with an inadequate response to antidepressants was common with a similar probability (76.1% vs 76.4%. The most frequently used antipsychotics were aripiprazole and quetiapine, however a substantial number of psychiatrists chose olanzapine, risperidone, and sulpiride. The major reason for not choosing aripiprazole was cost (52.1%, followed by insurance official policy audit and deletion in the claims review system (30.1%.Conclusion: The prescribing

  11. Eclipses and the Olympics

    Science.gov (United States)

    Pang, K. D.; Yau, K. K.

    2000-12-01

    Like returns of Halley's comet the Olympic games occur periodically, though not as regularly in antiquity. Dates were also imprecise due to the chaotic calendars in use. Reported sightings of comets and eclipses can be used with game dates to help fix ancient events. However some reported darkening of the sun, e.g., after Julius Caesar's murder in 44 BC, was due to volcanic eruptions. A red comet, visible in daylight, first appeared during the games that year. It was also seen from China and Korea (Pang, Sciences 31, 30). Phlegon's ``Olympiads" (2nd century) says that Christ's crucifixion was in the 4th year of the 202nd Olympiad (AD 29-33), when a total solar eclipse occurred in the 6th hour. Only the Nov. 24, AD 29 eclipse over Asia Minor can match that, and Joel's prophecy (Acts 2, 14-21) that ``the sun will be turned to darkness and moon to blood." However it conflicts with ``the first day of Passover," as recorded by Mathew, Mark and Luke, i.e., full moon in early spring. Humphreys and Waddington (Nature 306, 743) have suggested meteorological darkening and the April 3, AD 33 lunar eclipse instead. Schaefer has questioned the eclipse's visibility from Jerusalem (31.46N, 35.14E). The six computations he cited gave dissimilar answers due to the imprecise rates of the secular lunar acceleration, and lengthening of the day used (Q.Jl.R.astr.Soc. 31, 53). Lunar laser ranging has since fixed the former at -26"/cen2. Analysis of ancient Chinese solar eclipse records, e.g., the April 21, 899 BC and April 4, AD 368 ``double dawns" over Zheng, has given us a delta T (in sec) = 30t2, where t is centuries before 1800 (Pang, Yau and Chou, in ``Dynamics of Ice Age Earth: A Modern Perspective," 1998). Our computations show that the moon rose over Jerusalem, with 1/3 still in the umbra and the rest in penumbra. Holdover meteorological darkening with long absorption air mass could have help reddened the moon also. Finally the first ``eclipse season" (the Aug. 21 lunar, and

  12. A Basis Function Approach to Simulate Storm Surge Events for Coastal Flood Risk Assessment

    Science.gov (United States)

    Wu, Wenyan; Westra, Seth; Leonard, Michael

    2017-04-01

    Storm surge is a significant contributor to flooding in coastal and estuarine regions, especially when it coincides with other flood producing mechanisms, such as extreme rainfall. Therefore, storm surge has always been a research focus in coastal flood risk assessment. Often numerical models have been developed to understand storm surge events for risk assessment (Kumagai et al. 2016; Li et al. 2016; Zhang et al. 2016) (Bastidas et al. 2016; Bilskie et al. 2016; Dalledonne and Mayerle 2016; Haigh et al. 2014; Kodaira et al. 2016; Lapetina and Sheng 2015), and assess how these events may change or evolve in the future (Izuru et al. 2015; Oey and Chou 2016). However, numeric models often require a lot of input information and difficulties arise when there are not sufficient data available (Madsen et al. 2015). Alternative, statistical methods have been used to forecast storm surge based on historical data (Hashemi et al. 2016; Kim et al. 2016) or to examine the long term trend in the change of storm surge events, especially under climate change (Balaguru et al. 2016; Oh et al. 2016; Rueda et al. 2016). In these studies, often the peak of surge events is used, which result in the loss of dynamic information within a tidal cycle or surge event (i.e. a time series of storm surge values). In this study, we propose an alternative basis function (BF) based approach to examine the different attributes (e.g. peak and durations) of storm surge events using historical data. Two simple two-parameter BFs were used: the exponential function and the triangular function. High quality hourly storm surge record from 15 tide gauges around Australia were examined. It was found that there are significantly location and seasonal variability in the peak and duration of storm surge events, which provides additional insights in coastal flood risk. In addition, the simple form of these BFs allows fast simulation of storm surge events and minimises the complexity of joint probability

  13. Nucleophosmin (NPM1) gene variants in Egyptian patients with acute myeloid leukemia

    International Nuclear Information System (INIS)

    Ibrahim, G.H.

    2012-01-01

    To the editor Kassem et al. [1] described a novel mutational deletion [del 1178 (A)] in the 30 untranslated region of NPM1 gene detected in a heterozygous form in seven de novo acute myeloid leukemia (AML) patients of their study population. The described nucleotide deletion is an NPM1 gene polymorphism recorded in db SNP database (rs34351976; g28027: Genbank accession number NG 0 16018.1) (http://www.ncbi.nlm.nih.gov/projects/SNP/) and was described previously by Do hner et al. [2] and Chou et al. [3]. This variant accounted for 60-70% of AML patients with normal karyotype [2]. The putative deletion was also identified in healthy volunteers and persisted at complete remission and also at relapse of AML patients [3]. This deletion had no effect on the predicted amino acid sequence and is not in linkage disequilibrium with any previously identified NPM1 mutations [2,3]. Analysis of RNA folding at the region surrounding the rs34351976 in the presence or absence of the deletion using Mfold analysis software (http://www.mfold.rna.albany.edu) revealed no RNA folding change that may alter RNA splicing and subsequently gene expression. Furthermore, splicing motifs analysis using Human Splicing Finder software version 2.4.1 showed that the presence of the deletion does not abolish any recognition site of exonic or intronic enhancers or silencer motifs. In general, it seems that the impact of NMP1 polymorphisms on the molecular pathogenesis of AML is not clear yet and needs further investigation. Kassem et al. [1] describes the molecular aspect of de novo AML in the Egyptian population. The previously known NPM1 mutations mentioned in their study are less frequent compared to the figures recorded worldwide. Moreover, the authors wondered whether the NPM1 variants identified in their patients may confer a better outcome of AML. According to the previously mentioned data, one can speculate that the presence of NPM1 gene polymorphism (rs34351976) should not be mistaken as

  14. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pharmacology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pharmacology”ABS 1. BABY SKIN CARE PRODUCTS • P. Doro, R. Abraham, D. Agoston, J. Balog, R.Z. CsomaABS 2. MATHEMATICAL MODELING TO PREDICT IN-HOSPITAL NATURAL WEIGHT CHANGES IN TERM NEONATES • S. Kasser, M. Wilbaux, C. De Angelis, H. Rickenbacher, N. Klarer, J.N. Van Den Anker, M. Pfister, S. WellmannABS 3. IMPROVING PARENTERAL NUTRITION IN THE NEONATE – A PRACTICAL GUIDELINE • H. Reigstad, D. Moster, I. Grønlie, A. BlystadABS 4. INVOLUTION OF RETINOPATHY OF PREMATURITY AND NEURODEVELOPMENTAL OUTCOME AFTER BEVACIZUMAB TREATMENT • Y.-S. Chang, P.-N. Tsao, C.-Y. Chen, H.-C. Chou, W.-S. Hsieh, P.-T. YehABS 5. RELATIONSHIP BETWEEN ADVERSE DRUG REACTIONS AND OFF-LABEL/UNLICENSED DRUG USE IN HOSPITALISED CHILDREN. EREMI STUDY • K.A. Nguyen, Y. Mimouni, A. Lajoinie, N. Paret, S. Malik, L. El-Amrani, L. Milliat-Guittard, C. Carcel, A. Portefaix, A.M. Schott, T. Vial, B. KassaiABS 6. A SYSTEMATIC REVIEW OF OFF-LABEL AND UNLICENSED DRUGS USE AND ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN • N. David, K.A. Nguyen, Y. Mimouni, A. Lajoinie, S. Malik, B. KassaiABS 7. EFFICACY AND SAFETY OF PROPOFOL SEDATION

  15. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Lung and development”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    ñambres Rodríguez, A. Pino Vázquez, M. Brezmes Raposo, C. Fernández Garcia-Abril, C. Villa FranciscoABS 12. THE GESTATIONAL EFFECT OF ANTENATAL CORTICOSTEROIDS ON RESPIRATORY DISTRESS SYNDROME IN VERY LOW BIRTH WEIGHT INFANTS: A POPULATION BASED STUDY • S.Y. Liu, H.I. Yang, H.C. Chou, C.Y. Chen, W.S. Hsieh, K.I. Tsou, P.N. TsaoABS 13. PREECLAMPSIA AND THE RISK OF RESPIRATORY DISTRESS SYNDROME IN VLBW INFANTS: A POPULATION BASED STUDY • Y.H. Wen, H.I. Yang, W.S. Hsieh, H.C. Chou, C.Y. Chen, K.I. Tsou, P.N. TsaoABS 14. EFFECTIVENESS OF SINGLE DOSE SALBUTAMOL NEBULIZATION IN THE TREATMENT OF TRANSIENT TACHYPNEA OF THE NEWBORN: A DOUBLE BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL • M.L.B. Cruz, M.J.C. Racoma, V.O.M. Cloma-Rosales, M.V.J. CabahugABS 15. COMPARING THERAPEUTIC IMPACT OF BUBBLE CPAP WITH VARIABLE CPAP IN PREMATURE INFANT WITH RESPIRATORY DISTRESS • M. Noorishadkam, M.H. Lokzade, M. Eslami-Abrandabadi, E. Abbasi ShavaziABS 16. THE INCIDENCE OF RESPIRATORY MORBIDITY IN LATE PRETERM INFANT • G. Olariu, S. Olariu, M. TunescuABS 17. HYDROCORTISONE IN PRETERM INFANTS • C. Ramos-Navarro, M. Tomé-Perez, M. R. Ruiz-Gutierrez, S. Zeballos-Sarrato, N. Navarro-Patiño, I. Pescador-Chamorro, A. Rodriguez-De la Blanca, I. Marsinyach-Ross, M. Arriaga-Redondo, M. Sánchez-LunaABS 18. THE VALUE OF ULTRASOUND EXAMINATION IN PREDICTING CHRONIC LUNG DISEASE IN VLBW INFANTS UNDERGOING RESPIRATORY SUPPORT: PRELIMINARY RESULTS • S. Aversa, C. Zambelloni, R. Marzollo, V. Materia, F. Matina, G. ChiricoABS 19. RESPIRATORY DISTRESS OUTCOME AFTER SURFACTANT TREATMENT IN PREMATURE NEONATES OF LESS THAN 28 WEEKS OF GESTATION • M. Matyas1, L. Blaga, M. Hășmășanu, V. Obada, G. ZaharieABS 20. METABOLOMICS ANALYSIS ON THE BALF OF PRETERM INFANTS WITH A GESTATIONAL AGE LESS THAN 30 WEEKS TO IDENTIFY NEW BIOMARKERS OF BPD • F. Piersigilli, M. Syed, A. Dotta, C. Auriti, G. Salvatori, P. Vernocchi, E. Voss, T. Lam, V. BhandariABS 21. VENTILATOR-ASSOCIATED PNEUMONIA IN A NEONATAL

  16. Book Reviews

    Directory of Open Access Journals (Sweden)

    Chanatip Kesavadhana

    2000-01-01

    Full Text Available - A.S. Baer, Philip Houghton, People of the Great Ocean; Aspects of human biology of the early Pacific. Cambridge: Cambridge University Press, 1996, x + 292 pp. - Greg Bankoff, Vicente L. Rafael, Figures of criminality in Indonesia, the Philippines, and colonial Vietnam. Ithaca, NY: Cornell University Southeast Asis Program, 1999, 258 pp. - Harold Brookfield, Donald Denoon, The Cambridge history of the Pacific Islanders. Cambridge: Cambridge University Press, 1997, xvi + 518 pp., Stewart Firth, Jocelyn Linnekin (eds. - Cynthia Chou, Shoma Munshi, Clifford Sather, The Bajau Laut; Adaptation, history, and fate in a maritime fishing society of south-eastern Sabah. Kuala Lumpur: Oxford University Press, 1997, xviii + 359 pp. - Cynthia Chou, Shoma Munshi, Krishna Sen, Gender and power in affluent Asia. London: Routledge, 1998, xiii + 323 pp., Maila Stivens (eds. - Freek Colombijn, Arne Kalland, Environmental movements in Asia. Richmond, Surrey: Curzon, 1998, xiii + 296 pp. [Nordic Institute of Asian Studies, Man and Nature in Asia Series 4.], Gerard Persoon (eds. - Kirsten W. Endres, Phan Huy Chu, Hai trinh chi luoc; Récit sommaire d’un voyage en mer (1833; Un émissaire Vietnamien à Batavia. Paris: EHESS, 1994, viii + 228 pp. [Cahier d’Archipel 25.] - Aone van Engelenhoven, Veronica Du Feu, Rapanui. London: Routledge, 1996, xv + 217 pp. [Routledge Descriptive Grammars.] - Fukui Hayao, Peter Boomgard, Paper landscapes; Explorations in the environmental history of Indonesia, 1997, vi + 424 pp. Leiden: KITLV Press. [Verhandelingen 178.], Freek Colombijn, David Henley (eds. - Volker Heeschen, J. Miedema, Texts from the oral tradition in the south-western Bird’s Head Peninsula of Irian Jaya; Teminabuan and hinterland. Leiden: DSALCUL, Jakarta: ISIR, 1995, vi + 98 pp. [Irian Jaya Source Materials 14.] - Volker Heeschen, J. Miedema, Texts from the oral tradition in the southern Bird’s Head Peninsula of Irian Jaya; Inanwatan-Berau, Arandai

  17. Immersion freezing by SnomaxTM particles: Comparison of results from different instruments

    Science.gov (United States)

    Wex, Heike; Stratmann, Frank; Rösch, Michael; Niedermeier, Dennis; Nilius, Björn; Möhler, Ottmar; Mitra, Subir K.; Koop, Thomas; Jantsch, Evelyn; Hiranuma, Naruki; Diehl, Karoline; Curtius, Joachim; Budke, Carsten; Boose, Yvonne; Augustin, Stefanie

    2014-05-01

    Within the DFG funded research unit INUIT (Ice Nucleation research UnIT, FOR 1525), an effort was made to compare results on immersion freezing from a suite of different instruments. Besides mineral dusts, SnomaxTM was picked as one of the substances that were examined by all participating groups. Here, the comparison of the results for SnomaxTM is presented. Every participating group used SnomaxTM from the same batch and, as far as possible, the same particle generation set-up. Instruments participating in the comparison were, in alphabetical order, an acoustic levitator (Diehl et al., 2009), AIDA (Connolly et al., 2009), BINARY (Budke et al., 2013), FINCH (Bundke et al., 2008), LACIS (Hartmann et al., 2011), PINC (Chou et al., 2011) and the Mainz vertical windtunnel (Diehl et al., 2011). Some of the instruments examined droplets directly produced from SnomaxTM suspensions, where the suspensions could have a wide range of concentrations. Other instruments used size segregated particles which were generated via atomization from a SnomaxTM suspension and subsequent drying, followed by size selection with a DMA (Differential Mobility Analyzer). These particles were then activated to droplets and cooled subsequently. For these, the number of ice nucleation active protein complexes present in the droplets depended on the original particle size (for details see e.g. Hartmann et al., 2013). Also, the different measurements spanned a range of different time scales. The shortest residence time of roughly 1 second was used for LACIS measurements, and the longest one was about 6 seconds used in the BINARY setup with a cooling rate of 1 K/min. All data were evaluated using two different approaches: 1) a time dependent approach following Classical Nucleation Theory which included the use of a contact angle distribution (see Niedermeier et al., 2014); 2) a singular approach using an active site density per mass (see Vali, 1971, Murray et al., 2012). Both approaches were found

  18. Applications of High Intensity Proton Accelerators

    Science.gov (United States)

    Raja, Rajendran; Mishra, Shekhar

    2010-06-01

    Superconducting radiofrequency linac development at Fermilab / S. D. Holmes -- Rare muon decay experiments / Y. Kuno -- Rare kaon decays / D. Bryman -- Muon collider / R. B. Palmer -- Neutrino factories / S. Geer -- ADS and its potential / J.-P. Revol -- ADS history in the USA / R. L. Sheffield and E. J. Pitcher -- Accelerator driven transmutation of waste: high power accelerator for the European ADS demonstrator / J. L. Biarrotte and T. Junquera -- Myrrha, technology development for the realisation of ADS in EU: current status & prospects for realisation / R. Fernandez ... [et al.] -- High intensity proton beam production with cyclotrons / J. Grillenberger and M. Seidel -- FFAG for high intensity proton accelerator / Y. Mori -- Kaon yields for 2 to 8 GeV proton beams / K. K. Gudima, N. V. Mokhov and S. I. Striganov -- Pion yield studies for proton driver beams of 2-8 GeV kinetic energy for stopped muon and low-energy muon decay experiments / S. I. Striganov -- J-Parc accelerator status and future plans / H. Kobayashi -- Simulation and verification of DPA in materials / N. V. Mokhov, I. L. Rakhno and S. I. Striganov -- Performance and operational experience of the CNGS facility / E. Gschwendtner -- Particle physics enabled with super-conducting RF technology - summary of working group 1 / D. Jaffe and R. Tschirhart -- Proton beam requirements for a neutrino factory and muon collider / M. S. Zisman -- Proton bunching options / R. B. Palmer -- CW SRF H linac as a proton driver for muon colliders and neutrino factories / M. Popovic, C. M. Ankenbrandt and R. P. Johnson -- Rapid cycling synchrotron option for Project X / W. Chou -- Linac-based proton driver for a neutrino factory / R. Garoby ... [et al.] -- Pion production for neutrino factories and muon colliders / N. V. Mokhov ... [et al.] -- Proton bunch compression strategies / V. Lebedev -- Accelerator test facility for muon collider and neutrino factory R&D / V. Shiltsev -- The superconducting RF linac for muon

  19. Predictive factors warrant screening for obstructive sleep apnea in COPD: a Taiwan National Survey

    Directory of Open Access Journals (Sweden)

    Hang LW

    2016-03-01

    Full Text Available Liang-Wen Hang,1,2 Jeng-Yuan Hsu,3 Chee-Jen Chang,4 Hao-Chien Wang,5,6 Shih-Lung Cheng,7,8 Ching-Hsiung Lin,9 Ming-Cheng Chan,3 Chin-Chou Wang,10 Diahn-Warng Perng,11 Chong-Jen Yu5,6 On behalf of the Taiwan COPD Consortium 1Department of Respiratory Therapy, College of Health Care, China Medical University, 2Sleep Medicine Center, Department of Pulmonary and Critical Care Medicine, China Medical University Hospital, 3Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 4Biostatistical Center for Clinical Research, Chang Gung Memorial Hospital, Linkou Branch, Guishan Township, Taoyuan County, 5Department of Internal Medicine, National Taiwan University Hospital, 6Department of Internal Medicine, National Taiwan University, College of Medicine, Taipei, 7Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, 8Department of Chemical Engineering and Materials Science, Yuan Ze University, Chung-Li City, Taoyuan County, 9Division of Chest Medicine, Changhua Christian Hospital, Changhua City, Changhua County, 10Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 11Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China Background and objectives: COPD and obstructive sleep apnea (OSA share similar pathological processes and cardiovascular sequelae. Coexisting OSA in COPD – “overlap syndrome” – has worse prognosis than either condition alone, and appropriate treatment improves survival. Our objectives were to ascertain the frequency at which COPD coexists with the risk of OSA in Taiwan and to compare the risk factors, COPD symptoms, and life quality metrics between COPD subgroups with versus without risk of OSA. Methods: We conducted a random cross-sectional national telephone survey of adults >40 years old in Taiwan. Participants fulfilling an epidemiological case definition of COPD completed a

  20. Le national-populisme roumain aux portes de Bruxelles

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    Sorina Soare

    2005-09-01

    Full Text Available Le national-populisme marque visiblement le paysage politique roumain, mais c’est surtout le Parti de la Grande Roumanie, devenu récemment le Parti Populaire de la Grande Roumanie, qui réussit à s’assurer une constance électorale. Malgré ses résultats électoraux, son potentiel de coalition est complètement ignoré par tous les partis parlementaires roumains. D’ailleurs, le cordon sanitaire qui l’isole depuis 1996 assure indirectement la stabilité de la démocratie roumaine. Comment appréhender alors le national-populisme roumain ? L’article propose une interprétation socio-historique qui met en évidence le caractère caméléonesque du parti. Plusieurs éléments du discours du parti sont analysés par une grille d’analyse à trois niveaux : le discours populiste, la défense de la nation et le potentiel de rupture. En même temps, dans la perspective de l’élargissement de 2007, les conclusions de l’article portent sur les stratégies échouées de démantèlement de l’ostracisme national et international.El nacional-populismo marca de manera visible el panorama político rumano, pero es sobre todo el Partido de la Gran Rumania, convertido recientemente en el Partido Popular de la Gran Rumania, el que ha conseguido asegurarse una constancia electoral. A pesar de sus resultados electorales, su potencial para formar coalición ha sido ignorado completamente por los partidos parlamentarios rumanos. Por otro lado, el cordón sanitario que le aísla desde 1996, asegura de manera indirecta la estabilidad de la democracia rumana. ¿Cómo se puede temer pues el nacional-populismo rumano? El artículo propone una interpretación socio-histórica que pone en evidencia el carácter camaleónico del partido. En el se analizan otros elementos del discurso del partido a través de tres niveles: el discurso populista, la defensa de la nación y el potencial de ruptura. Al mismo tiempo, dentro de la perspectiva de ampliaci

  1. Effects of a selective educational system on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan

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    Chen TY

    2015-03-01

    Full Text Available Tien-Yu Chen,1,2 Yu-Ching Chou,3 Nian-Sheng Tzeng,1,2,4 Hsin-An Chang,1,2,4 Shin-Chang Kuo,1,2,5 Pei-Yin Pan,1,2 Yi-Wei Yeh,1,2,5 Chin-Bin Yeh,1,2 Wei-Chung Mao1,2,6 1Department of Psychiatry, Tri-Service General Hospital, 2School of Medicine, National Defense Medical Center, 3School of Public Health, National Defense Medical Center, 4Student Counseling Center, National Defense Medical Center, 5Graduate Institute of Medical Sciences, National Defense Medical Center, 6Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Republic of China Objective: The aim of the study reported here was to clarify the effects of academic pressure on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan. Methods: This cross-sectional study enrolled 757 senior high school adolescents who were classified into four groups: Grade 1 (n=261, Grade 2 (n=228, Grade 3T (n=199; Grade 3 students who had another college entrance test to take, and Grade 3S (n=69; Grade 3 students who had succeeded in their college application. Fatigue, sleep quality, daytime sleepiness, and depression were assessed using the Chinese version of the Multidimensional Fatigue Symptom Inventory – Short Form, Pittsburgh Sleep Quality Index-Taiwan Form, the Chinese version of the Epworth Sleepiness Scale, and the Chinese version of the Beck Depression Inventory®-II (BDI-II, respectively. Results: Physical, emotional, and mental fatigue scores were all higher in higher-grade groups. The Grade 3T (test students had the worst fatigue severity, and the Grade 3S (success students had the least fatigue severity. More than half of the students (60.9% went to bed after 12 am, and they had on average 6.0 hours of sleep per night. More than 30% of the students in Grade 2 (37.3% and Grades 3T/S (30.2%/30.4% possibly had daily sleepiness problems. The students in Grade 3T had the worst BDI-II score (13.27±9.24, and the Grade 3S

  2. Comparison of anterior decompression and fusion versus laminoplasty in the treatment of multilevel cervical ossification of the posterior longitudinal ligament: a systematic review and meta-analysis

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    Liu W

    2016-04-01

    Full Text Available Weijun Liu,1,* Ling Hu,2,* Po-Hsin Chou,3 Ming Liu,1 Wusheng Kan,1 Junwen Wang1 1Department of Orthopedics, Pu Ai Hospital, Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Anesthesiology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Orthopedics & Traumatology, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC *These authors contributed equally to this work Purpose: A meta-analysis was conducted to evaluate the clinical outcomes, complications, reoperation rates, and late neurological deterioration between anterior decompression and fusion (ADF and laminoplasty (LAMP in the treatment of multilevel cervical ossification of the posterior longitudinal ligament (OPLL. Methods: All related studies published up to August 2015 were acquired by searching PubMed and EMBASE. Exclusion criteria were case reports, revision surgeries, combined anterior and posterior surgeries, the other posterior approaches including laminectomy or laminectomy and instrumented fusion, non-English studies, and studies with quality assessment scores of <7. The main end points including Japanese Orthopedic Association (JOA score, recovery rate of JOA, cervical lordosis, complication rate, reoperation rate, and late neurological deterioration were analyzed. All available data was analyzed using RevMan 5.2.0 and Stata 12.0. Results: A total of seven studies were included in the meta-analysis. The mean surgical level of ADF was 3.1, and the mean preoperative occupation ratios of ADF and LAMP group were 55.9% and 51.9%, respectively. No statistical difference was observed with regard to preoperative occupation ratio and preoperative JOA score. Although LAMP group had a higher preoperative cervical lordosis than ADF group (P<0.05, weighted mean difference [WMD

  3. Clinical effectiveness, toxicity, and failure patterns of helical tomotherapy for postoperative oral cavity cancer patients

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    Hsieh CH

    2014-03-01

    Full Text Available Chen-Hsi Hsieh,1–3 Pei-Wei Shueng,1,4 Li-Ying Wang,5 Li-Jen Liao,6 Yu-Chin Lin,7 Ying-Shiung Kuo,8 Wu-Chia Lo,6 Chien-Fu Tseng,8 Hui-Ju Tien,1 Hsiu-Ling Chou,9,10 Yen-Ping Hsieh,11 Le-Jung Wu,1 Yu-Jen Chen3,12–14 1Department of Radiation Oncology, Far Eastern Memorial Hospital, 2Department of Medicine, 3Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, 4Department of Radiation Oncology, National Defense Medical Center, 5School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, 6Department of Otolaryngology, 7Division of Medical Oncology and Hematology, Department of Internal Medicine, 8Department of Dentistry and Oral Surgery, 9Department of Nursing, Far Eastern Memorial Hospital, 10Department of Nursing, Oriental Institute of Technology, Taipei, 11Department of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung, 12Department of Radiation Oncology, 13Department of Medical Research, Mackay Memorial Hospital, 14Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan Background: The outcome of postoperative high- and intermediate-risk oral cavity cancer (OCC patients receiving helical tomotherapy (HT remains limited. Materials and methods: Between November 2006 and November 2012, 53 postoperative high- and intermediate-risk OCC patients treated with HT were enrolled. Results: The 4-year locoregional, local, and regional control rates were 66%, 76.4%, and 94.3%, respectively. The 4-year locoregional control rates of oral tongue and buccal mucosa cancer were 88.3% and 37.1%, respectively (P=0.012. Eleven (20.8% patients experienced locoregional failure. In-field failure occurred in six of 53 (11.3% in the primary area and three of 53 (5.7% in the regional lymph-node area. No marginal failure was noted. Two of 53 (3.8% experienced out-of-field failure. The rates of grade 3 dermatitis

  4. Hypercitizenship and the Management of Genetic Diversity/Hyper-citoyenneté et gestion de la diversité génétique. La sociologie du droit et la bifurcation systemique principale entre la singularité du RING et l'âge néoféodale

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    Pitasi Andrea

    2011-12-01

    Full Text Available Cet essai se focalise sur la fonction allocative des systèmes judiciaires exercée pour attirer/rejeter des capitauxdifférents sur la base de leur propres procédures de création de règles juridiques et de lois. Cette fonction estaujourd’hui d’une importance fondamentale. En effet, le genre humain est avant tout une bifurcation évolutionniste etsystémique entre le concept heideggérien de Gegnet d’une convergence stratégique et extrêmement rapide (parexemple, la Singularité parmi la robotique, l’informatique, les nanotechnologies et la génétique (RINGs – qui est entrain de redessiner la vie humaine par rapport à ses styles et ses standards qualitatifs de vie et tout particulièrement auxdomaines de la santé et de l’environnement - et ce qu’on appelle le Scenario Néo-féodal (NS proposé par ceux quipensent que le Modèle Industriel a échoué et que le seul moyen de sauver le genre humain et son environnement seraitune espèce de voyage en arrière dans le temps pour proposer de nouveau le style de vie du Moyen-âge caractérisé par lalenteur et l’austérité. Cet essai examine la littérature internationale la plus récente et la plus influente concernante lesdeux alternatives de bifurcation et avance une modification potentielle de paradigme dans l’approche systémique afin dereformuler la carte conceptuelle du changement global à travers une épistémologie systémique de la sociologie du droit.AbstractThis essay is essentially theoretical and is focused on the allocative function of the legal systems to attract/rejectdifferent capitals according to their procedures to shape norms and laws. This function of the legal systems is pivotal inour times as humankind is before a systemic and evolutionary bifurcation between the heideggerian Gegnet of astrategic, high speed convergence (i.e. Singularity among robotics, informatics, nanotechonologies and genetics(RINGs - which is going to reshape the human life

  5. Repeated vertebral augmentation for new vertebral compression fractures of postvertebral augmentation patients: a nationwide cohort study

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    Liang CL

    2015-03-01

    Full Text Available Cheng-Loong Liang,1 Hao-Kwan Wang,1 Fei-Kai Syu,2 Kuo-Wei Wang,1 Kang Lu,1 Po-Chou Liliang1 1Department of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan; 2Department of Pharmacy, China Medical University Hospital, Taichung City, Taiwan Purpose: Postvertebral augmentation vertebral compression fractures are common; repeated vertebral augmentation is usually performed for prompt pain relief. This study aimed to evaluate the incidence and risk factors of repeat vertebral augmentation.Methods: We performed a retrospective, nationwide, population-based longitudinal observation study, using the National Health Insurance Research Database (NHIRD of Taiwan. All patients who received vertebral augmentation for vertebral compression fractures were evaluated. The collected data included patient characteristics (demographics, comorbidities, and medication exposure and repeat vertebral augmentation. Kaplan–Meier and stratified Cox proportional hazard regressions were performed for analyses.Results: The overall incidence of repeat vertebral augmentation was 11.3% during the follow-up until 2010. Patients with the following characteristics were at greater risk for repeat vertebral augmentation: female sex (AOR=1.24; 95% confidence interval [CI]: 1.10–2.36, advanced age (AOR=1.60; 95% CI: 1.32–2.08, diabetes mellitus (AOR=4.31; 95% CI: 4.05–5.88, cerebrovascular disease (AOR=4.09; 95% CI: 3.44–5.76, dementia (AOR=1.97; 95% CI: 1.69–2.33, blindness or low vision (AOR=3.72; 95% CI: 2.32–3.95, hypertension (AOR=2.58; 95% CI: 2.35–3.47, and hyperlipidemia (AOR=2.09; 95% CI: 1.67–2.22. Patients taking calcium/ vitamin D (AOR=2.98; 95% CI: 1.83–3.93, bisphosphonates (AOR=2.11; 95% CI: 1.26–2.61, or calcitonin (AOR=4.59; 95% CI: 3.40–5.77 were less likely to undergo repeat vertebral augmentation; however, those taking steroids (AOR=7.28; 95% CI: 6.32–8.08, acetaminophen (AOR=3.54; 95% CI: 2.75–4.83, or nonsteroidal

  6. Music therapy-induced changes in salivary cortisol level are predictive of cardiovascular mortality in patients under maintenance hemodialysis

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    Hou YC

    2017-02-01

    Full Text Available Yi-Chou Hou,1 Yen-Ju Lin,2 Kuo-Cheng Lu,1 Han-Sun Chiang,3 Chia-Chi Chang,4 Li-King Yang1 1Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 2Department of Nursing, Taipei Medical University, 3Graduate Institute of Basic Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, 4School of Gerontology Health Management, College of Nursing, Taipei Medical University, Taipei, Taiwan, Republic of China Background: Music therapy has been applied in hemodialysis (HD patients for relieving mental stress. Whether the stress-relieving effect by music therapy is predictive of clinical outcome in HD patients is still unclear.Methods: We recruited a convenience sample of 99 patients on maintenance HD and randomly assigned them to the experimental (n=49 or control (n=50 group. The experimental group received relaxing music therapy for 1 week, whereas the control group received no music therapy. In the experimental group, we compared cardiovascular mortality in the patients with and without cortisol changes.Results: The salivary cortisol level was lowered after 1 week of music therapy in the experimental group (−2.41±3.08 vs 1.66±2.11 pg/mL, P<0.05, as well as the frequency of the adverse reaction score (−3.35±5.76 vs −0.81±4.59, P<0.05, the severity of adverse reactions score (−1.93±2.73 vs 0.33±2.71, P<0.05, and hemodialysis stressor scale (HSS score (−6.00±4.68 vs −0.877±7.08, P<0.05. The difference in salivary cortisol correlated positively with HD stress score scales (r=0.231, P<0.05, systolic blood pressure (r=0.264, P<0.05, and respiratory rates (r=0.369, P<0.05 and negatively with finger temperature (r=−0.235, P<0.05 in the total study population. The 5-year cardiovascular survival in the experimental group was higher in patients whose salivary cortisol lowered by <0.6 pg/mL than that in patients whose salivary cortisol lowered by >0.6 pg/mL (83.8% vs

  7. La réinvention des routes incas : représentations et construction de la mémoire au Pérou (2001-2011 The Reinvention of the Inca Roads: Representations and Construction of Memory in Peru (2001-2011 La reinvención de las rutas incas: representaciones y construcción de la memoria en el Perú (2001-2011

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    Sébastien Jallade

    2012-05-01

    Full Text Available Le « Qhapaq Ñan » (chemin principal andin constitue un exemple éclairant d’institutionnalisation de la mémoire au Pérou, marqué par quatre facteurs : le rôle central dévolu aux scientifiques et aux organisations internationales favorise l’irruption de logiques de développement et de patrimonialisation ; l’État péruvien privilégie une représentation symbolique du territoire au profit d’un public de plus en plus globalisé; la « Marche pour la paix », une commémoration politique ancrée dans le contexte local, a été marquée par un succès populaire important, mais non relayé par les élites ; enfin les projets de tourisme soutenable fondés sur des objectifs de conservation et d’authenticité ont échoué à donner une réalité concrète à leurs propositions. Ces différentes stratégies n’ont jamais réussi à impliquer durablement les communautés riveraines, et ce malgré les objectifs affichés à l’origine. Elles témoignent des enjeux contradictoires de la représentation des Andes péruviennes dans le contexte d’un pays pluriculturel.The «Qhapaq Ñan» (main Andean road is a unprecedented example of institutionalization of memory in contemporary Peru, characterized by four aspects: the central role given to scientists and international organizations favors the emergence of patterns of development and heritage listing; the Peruvian State tends to stress a symbolic representation of territory for the benefit of a globalized audience; the «Peace march», a political initiative well grounded in the local context, was rewarded by significant popular success, but the elite did not follow it up; finally, sustainable tourism projects based on conservation and authenticity goals have failed to put their proposals in practice. The original objectives stressing participation of local communities were not achieved on a lasting basis. These findings underline conflicting issues of representation of the

  8. Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

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    Lin JF

    2017-05-01

    Full Text Available Ji-Fan Lin,1 Yi-Chia Lin,2 Te-Fu Tsai,2,3 Hung-En Chen,2 Kuang-Yu Chou,2,3 Thomas I-Sheng Hwang2–4 1Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 2Division of Urology, School of Medicine, Fu-Jen Catholic University, New Taipei, 3Division of Urology, Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, 4Department of Urology, Taipei Medical University, Taipei, Taiwan Purpose: Cisplatin-based chemotherapy is the first line treatment for several cancers including bladder cancer (BC. Autophagy induction has been implied to contribute to cisplatin resistance in ovarian cancer; and a high basal level of autophagy has been demonstrated in human bladder tumors. Therefore, it is reasonable to speculate that autophagy may account for the failure of cisplatin single treatment in BC. This study investigated whether cisplatin induces autophagy and the mechanism involved using human BC cell lines.Materials and methods: Human BC cells (5637 and T24 were used in this study. Cell viability was detected using water soluble tetrazolium-8 reagents. Autophagy induction was detected by monitoring the levels of light chain 3 (LC3-II and p62 by Western blot, LC3-positive puncta formation by immunofluorescence, and direct observation of the autophagolysosome (AL formation by transmission electron microscopy. Inhibitors including bafilomycin A1 (Baf A1, chloroquine (CQ, and shRNA-based lentivirus against autophagy-related genes (ATG7 and ATG12 were utilized. Apoptosis level was detected by caspase 3/7 activity and DNA fragmentation.Results: Cisplatin decreased cell viability and induced apoptosis of 5637 and T24 cells in a dose- and time-dependent manner. The increased LC3-II accumulation, p62 clearance, the number of LC3-positive puncta, and ALs in cisplatin-treated cells suggested that cisplatin indeed induces autophagy. Inhibition of cisplatin-induced autophagy using Baf A1, CQ, or ATG7/ATG12 shRNAs significantly enhanced cytotoxicity of

  9. IQ discrepancy differentiates levels of fine motor skills and their relationship in children with autism spectrum disorders

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    Yu TY

    2018-02-01

    Full Text Available Tzu-Ying Yu,1 Willy Chou,2,3 Julie Chi Chow,4 Chien-Ho Lin,5 Li-Chen Tung,2,6 Kuan-Lin Chen7,8 1Department of Occupational Therapy, College of Medicine, I-Shou University, Kaohsiung, 2Department of Physical Medicine and Rehabilitation, Chi-Mei Medical Center, 3Department of Recreation and Health Care Management, Cha Nan University of Pharmacy and Science, 4Department of Pediatrics, 5Department of Psychiatry, Chi Mei Medical Center, Tainan, 6Department of Physical Medicine and Rehabilitation, Da Chien General Hospital, Miaoli, 7Department of Occupational Therapy, College of Medicine, National Cheng Kung University, 8Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, Tainan, Taiwan Purpose: We investigated 1 the impact of differences in intelligence quotient discrepancy (IQD on motor skills of preschool-aged children with autism spectrum disorders (ASD; 2 the relationships between IQD and motor skills in preschool-aged children with ASD. Methods: A total of 127 ASD preschool-aged children were divided into three groups according to the size of the IQD: IQD within 1 standard deviation (1SD; EVENIQ; n=81, discrepantly higher verbal intelligence quotient (VIQ; n=22; VIQ>performance intelligence quotient [PIQ] above 1SD [≥15 points], and discrepantly higher PIQ (n=24; PIQ>VIQ above 1SD [≥15 points]. Children’s IQD and motor skills were determined with the Wechsler Preschool and Primary Scale of Intelligence™ – Fourth Edition and the motor subtests of the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT, respectively. Results: One-way analysis of variance revealed significant group differences for the fine motor domain of the CDIIT and the visual–motor coordination subtest (F=3.37–4.38, p<0.05. Children with discrepantly higher PIQ were associated with better fine motor skills than were children with even IQD and those with discrepantly higher VIQ, and vice versa. IQD (PIQ

  10. Intelligence quotient discrepancy indicates levels of motor competence in preschool children at risk for developmental delays

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    Yu TY

    2016-02-01

    Full Text Available Tzu-Ying Yu,1 Kuan-Lin Chen,2,3 Willy Chou,4,5 Shu-Han Yang,4 Sheng-Chun Kung,4 Ya-Chen Lee,2 Li-Chen Tung4,6,7 1Department of Occupational Therapy, College of Medicine, I-Shou University, Kaohsiung, 2Department of Occupational Therapy, College of Medicine, National Cheng Kung University, Tainan, 3Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 4Department of Physical Medicine and Rehabilitation, Chi-Mei Medical Center, Tainan, 5Department of Recreation and Health Care Management, Cha Nan University of Pharmacy and Science, Tainan, 6School of Medicine, Kaohsiung Medical University, Kaohsiung, 7School of Medicine, Chung Shan Medical University, Taichung, Taiwan Purpose: This study aimed to establish 1 whether a group difference exists in the motor competence of preschool children at risk for developmental delays with intelligence quotient discrepancy (IQD; refers to difference between verbal intelligence quotient [VIQ] and performance intelligence quotient [PIQ] and 2 whether an association exists between IQD and motor competence.Methods: Children’s motor competence and IQD were determined with the motor subtests of the Comprehensive Developmental Inventory for Infants and Toddlers and Wechsler Preschool and Primary Scale of Intelligence™ – Fourth Edition. A total of 291 children were included in three groups: NON-IQD (n=213; IQD within 1 standard deviation [SD], VIQ>PIQ (n=39; VIQ>PIQ greater than 1 SD, and PIQ>VIQ (n=39; PIQ>VIQ greater than 1 SD.Results: The results of one-way analysis of variance indicated significant differences among the subgroups for the “Gross and fine motor” subdomains of the Comprehensive Developmental Inventory for Infants and Toddlers, especially on the subtests of “body-movement coordination” (F=3.87, P<0.05 and “visual-motor coordination” (F=6.90, P<0.05. Motor competence was significantly

  11. COPD in Taiwan: a National Epidemiology Survey

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    Cheng SL

    2015-11-01

    Full Text Available Shih-Lung Cheng,1,2 Ming-Cheng Chan,3 Chin-Chou Wang,4 Ching-Hsiung Lin,5 Hao-Chien Wang,6 Jeng-Yuan Hsu,3 Liang-Wen Hang,7,8 Chee-Jen Chang,9 Diahn-Warng Perng,10,* Chong-Jen Yu6,* On behalf of the Taiwan COPD Consortium 1Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, 2Department of Chemical Engineering and Materials Science, Yuan Ze University, Chung-Li City, Taoyuan County, 3Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 4Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 5Division of Chest Medicine, Changhua Christian Hospital, Changhua City, Changhua County, 6Department of Internal Medicine, National Taiwan University Hospital, Taipei, 7Department of Pulmonary and Critical Care Medicine, Sleep Medicine Center, China Medical University Hospital, 8Department of Respiratory Therapy, College of Health Care, China Medical University, Taichung, 9Biostatistical Center for Clinical Research, Chang Gung Memorial Hospital, Linkou Branch, Guishan Township, Taoyuan County, 10Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Objectives: To determine the prevalence of COPD in Taiwan and to document the disease characteristics and associated risk factors.Methods: We conducted a random cross-sectional national survey of adults older than 40 years in Taiwan. Respiratory health screening questions identified subjects with diagnosed COPD or whose reported symptoms also fulfilled an epidemiological case definition; these were eligible to complete the survey, which also included indices of symptom severity and disability and questions on comorbidities, medical treatments, smoking habits, and occupations potentially harmful to respiratory health. Subjects with diagnosed COPD were subdivided by smoking status. Subjects who fulfilled the case definition

  12. « Mr Azn@r, parT »

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    Ludivine Thouverez

    2004-09-01

    Full Text Available Les attentats du 11 mars 2004 à Madrid ont illustré le divorce existant entre les médias et la société civile espagnole. En fonctionnant comme de simple courroies de transmission du discours gouvernemental (lequel souhaitait incriminer l'ETA pour ne pas perdre les élections, les médias ont échoué dans leur mission de rendre une information libre et plurielle de la res publica. Durant la crise, les NTIC, nouvelles technologies de l'information et de la communication, ont joué un rôle de contre-pouvoir médiatique et social. La communication horizontale permit aux opinions divergentes de pouvoir s'exprimer. En outre, les NTIC favorisèrent les mobilisations citoyennes de la veille des élections. L'alliance NTIC - civils peut-elle mettre fin à la manipulation de l'information ? Va-t-elle obliger les hommes politiques et les médias traditionnels à une plus grande transparence ? Va-t-elle révolutionner les pratiques démocratiques ? Le terrorisme et son traitement médiatique sont des sujets complexes. Ils sont basés sur des intérêts contraires et s'inscrivent dans un contexte sociopolitique qui conditionne le discours de la presse sur l'acte terroriste. Si les nouvelles technologies élargissent le champ de l'espace public, elles n'offrent guère de solutions quant aux problèmes que rencontrent les journalistes en cas de terrorisme.Los atentados del 11-M en Madrid evidenciaron un divorcio entre los medios de comunicación y la sociedad civil española. Al funcionar como meras correas de transmisión del discurso del poder político (el cual quería incriminar a ETA para no perder las elecciones los medias fallaron en su misión de transmitir una información libre y plural de la res publica. Durante la crisis, las NTIC, nuevas tecnologías de la información y de la comunicación actuaron como contrapoder social y mediático. La comunicación horizontal permitió que se pudieran expresar opiniones contrarias a las del gobierno

  13. Petrological, geochemical and isotopic characteristics of lignite and calcified lignite from mining area Pesje, Velenje Basin, Slovenia

    Science.gov (United States)

    Vrabec, Mirijam; Markič, Miloš; Vrabec, Marko; Jaćimović, Radojko; Kanduč, Tjaša

    2014-05-01

    energy dispersive X-ray spectroscopy at the Department of Ceramics at the Jožef Stefan Institute. Geochemical characteristics of major and trace elements indicate that the values of major and trace elements are comparable to world average coal (Zhang et al., 2004). Isotopic composition of carbon and isotopic composition of nitrogen of investigated samples indicate values from to -29.4o to -23.7o and 1.8o to 5.9o respectively. Lower value of isotopic composition of carbon indicates higher gelification (values up to -29.4) and higher value of isotopic composition of nitrogen (values up to 5.9) indicate higher mineralization. The results of SEM/EDXS microscopy revealed that in calcified lignite chemical composition of calcite prevails. Traces of diagenetic pyrite were also found, indicating localized anoxic conditions during sedimentation. Values of isotopic composition of CCaCO3 range from -2 to +13 and indicate temperature of precipitation from 17.3 to 35 deg C, which is similar to results obtained in previous studies (Kanduč et al., 2012). References Krantz, D.E., Williams, D.F., Jones, D.S., 1987: Ecological and paleoenvironmental information using stable isotope profiles from living and fossil mollusks. Palaeogeography, Palaeoclimatology, Palaeoecology 58, 249-266. Kanduč T., Markič M., Zavšek S., McIntosh J. 2012: carbon cycling in the Pliocene Velenje Coal Basin, Slovenia, inferred from stable carbon isotopes. International Journal of Coal Geology 89, 70-83. Jaćimović, R., Lazaru, A., Mihajlović, D., Ilić, R., Stafilov, T., 2002: Determination of major and trace elements in some minerals by k0-instrumental neutron activation analysis. Journal of Radioanalytical Nuclear Chemistry, 253, 427-434. McCrea, JM., 1950. On the isotopic chemistry of carbonates and a paleotemperature scale. Journal of Chemical Physics 18, 849. Ward C.R. (Ed.), 1984: Coal Geology and Coal Technology. Black-well, Oxford, 345 pp. Zhang J.Y., Zheng C.G., Ren D.Y., Chou C.L., Zheng R

  14. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Neonatology and NICU clinical care and practices”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    Full Text Available Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Neonatology and NICU clinical care and practices”ABS 1. BILATERAL CLAVICLE FRACTURE: A RARE CAUSE OF PERSISTENT CRYING • P. Cruz, P. Mendes, M. Anselmo, L. GonçalvesABS 2. NEONATAL TRANSPORT DURATION AND SHORT-TERM OUTCOME IN VERY-LOW-GESTATIONAL-AGE NEONATES • A. Matic, M. Gavrilovic LatinovicABS 3. PEMPHIGOID GESTATIONIS – A RARE CASE IN TWIN PREGNANCY • L. Gonçalves, E. Scortenschi, P. Cruz, P. Mendes, M. AnselmoABS 4. DEVELOPMENT OF A CLINICIAN-REPORTED OUTCOME (ClinRO MEASURE TO ASSESS READINESS FOR DISCHARGE FROM NEONATAL CARE AMONG EXTREMELY PRETERM INFANTS • M. Turner, R. Ward, J. Higginson, I. Hansen-Pupp, M. Vanya, E. Flood, G. Quiggle, A. Tocoian, A. Mangili, N. Barton, S. SardaABS 5. THE EFFECT OF THYROID HORMONES ON NICU ADMISSION DUE TO TRANSIENT TACHYPNEA OF NEWBORN IN LATE PRETERM AND TERM INFANTS • T. Gursoy, S. Ercin, P. Kayiran, B. GurakanABS 6. IMPROVING THE QUALITY OF PROLONGED JAUNDICE WORK-UPS IN THE OUTPATIENT DEPARTMENT IN A TERTIARY NEONATAL CENTRE • C.M. Moore, J. O’Loughlin, B.C. HayesABS 7. SAVE THE DATE? CORRECT RECORDING OF DAY OF LIFE AND CORRECTED GESTATIONAL AGE IN NICU • C.M. Moore, A.F. El-KhuffashABS 8. PARENTS IN NICU: THE IMPORTANCE OF INTEGRATION BETWEEN THE CURE AND THE CARE • G. De Bernardo, M. Svelto, M. Giordano, D. SordinoABS 9. THE PREVALENCE OF HEREDITARY HEARING LOSS IN 41,152 NEWBORNS DURING THE PERIOD 2011-2015 • S.T. Hsu, C.C. Hung, Y.N. Su, C.Y. Chen, H.C. Chou, W.S. Hsieh, C.C. Wu, P.N. TsaoABS 10. DEFICIENCY OF MULTIPLE acyl-CoA DEHYDROGENASE OR GLUTARIC ACIDURIA TYPE II • M. Torres, L. Geronès, J. Herrero, M.C. Cèspedes, F. Camba, J.A. Arranz, M. del Toro, F. CastilloABS 11. TEN YEARS OF EXPERIENCE IN CARRIER SCREENING FOR SPINAL MUSCULAR ATROPHY IN TAIWAN • C.Y. Chuang, C.C. Hung, Y.N. Su, P.N. TsaoABS 12. REDUCING MEDICATION ERRORS ON THE

  15. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2004-04-01

    Full Text Available -Timothy P. Barnard, Cynthia Chou, Indonesian sea nomads; Money, magic, and fear of the Orang Suku Laut. London: RoutledgeCurzon, 2003, xii + 159 pp. -R.H. Barnes, Toos van Dijk, Gouden eiland in de Bandazee; Socio-kosmische ideeën op Marsela, Maluku Tenggara, Indonesië. Leiden: Onderzoekschool voor Aziatische, Afrikaanse en Amerindische studies (CNWS, Universiteit Leiden, 2000, 458 pp. [CNWS Publications 94.] -Andrew Beatty, Peter G. Riddell, Islam and the Malay-Indonesian world; Transmission and responses. Honolulu: University of Hawai'i Press, 2001, xvii + 349 pp. -Peter Boomgaard, Richard H. Grove ,El Niño - history and crisis; Studies from the Asia-Pacific region. Cambridge: White Horse Press, 2000, 230 pp., John Chappell (eds -Bernardita Reyes Churchill, Florentino Rodao, Franco y el imperio japonés; Imágenes y propaganda en tiempos de guerra. Barcelona: Plaza and Janés, 2002, 669 pp. -Matthew Cohen, Stuart Robson, The Kraton; Selected essays on Javanese courts. Translated by Rosemary Robson-McKillop. Leiden: KITLV Press, 2003, xxvi + 397 pp. [Translation series 28.] -Serge Dunis, Ben Finney, Sailing in the wake of the ancestors; Reviving Polynesian voyaging. Honolulu: Bishop Museum Press, 2003, 176 pp. [Legacy of excellence.] -Heleen Gall, Jan A. Somers, De VOC als volkenrechtelijke actor. Deventer: Gouda Quint, Rotterdam: Sanders Instituut, 2001, x + 350 pp. -David Henley, Harold Brookfield, Exploring agrodiversity. New York: Columbia University Press, 2001, xix + 348 pp. -David Hicks, Ernst van Veen ,A guide to the sources of the history of Dutch-Portuguese relations in Asia (1594-1797. With a foreword by Leonard Blussé. Leiden: Institute for the history of European expansion, 2001, iv + 378 pp. [Intercontinenta 24.], Daniël Klijn (eds -Nico Kaptein, Donald J. Porter, Managing politics and Islam in Indonesia. London: RoutledgeCurzon, 2002, xxi + 264 pp. -Victor T. King, Monica Janowski, The forest, source of life; The Kelabit of

  16. Illicit Drug Use, Illicit Drug Use Disorders, and Drug Overdose Deaths in Metropolitan and Nonmetropolitan Areas - United States.

    Science.gov (United States)

    Mack, Karin A; Jones, Christopher M; Ballesteros, Michael F

    2017-10-20

    small metropolitan or nonmetropolitan areas throughout the study period. Notably, past-month use of illicit drugs declined over the study period for the youngest respondents (aged 12-17 years). The prevalence of past-year illicit drug use disorders among persons using illicit drugs in the past year varied by metropolitan/nonmetropolitan status and changed over time. Across both metropolitan and nonmetropolitan areas, the prevalence of past-year illicit drug use disorders declined during 2003-2014. In 2015, approximately six times as many drug overdose deaths occurred in metropolitan areas than occurred in nonmetropolitan areas (metropolitan: 45,059; nonmetropolitan: 7,345). Drug overdose death rates (per 100,000 population) for metropolitan areas were higher than in nonmetropolitan areas in 1999 (6.4 versus 4.0), however, the rates converged in 2004, and by 2015, the nonmetropolitan rate (17.0) was slightly higher than the metropolitan rate (16.2). Drug use and subsequent overdoses continue to be a critical and complicated public health challenge across metropolitan/nonmetropolitan areas. The decline in illicit drug use by youth and the lower prevalence of illicit drug use disorders in rural areas during 2012-2014 are encouraging signs. However, the increasing rate of drug overdose deaths in rural areas, which surpassed rates in urban areas, is cause for concern. Understanding the differences between metropolitan and nonmetropolitan areas in drug use, drug use disorders, and drug overdose deaths can help public health professionals to identify, monitor, and prioritize responses. Consideration of where persons live and where they die from overdose could enhance specific overdose prevention interventions, such as training on naloxone administration or rescue breathing. Educating prescribers on CDC's guideline for prescribing opioids for chronic pain (Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain-United States, 2016. MMWR Recomm Rep

  17. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Epidemiology, perinatology and DOHaD”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    Full Text Available Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Epidemiology, perinatology and DOHaD”ABS 1. THE INFLUENCE OF MATERNAL PREGESTATIONAL OBESITY IN OFFSPRING. A NEW PUBLIC HEALTH PROBLEM • P. Priego, N. Sancho, I. Tofe, A. Torre, M.D. CañeteABS 2. UNPLANNED NEONATAL ADMISSION RATE AFTER ELECTIVE FAMILY CENTERED CAESAREAN SECTIONS • I.C. Narayen, E.E.M. Mulder, L.M. Freeman, J.J. Van Vonderen, K.E. Boers, A.B. Te PasABS 3. CESAREAN DELIVERY AMONG FOREIGN-BORN CHINESE AND US-BORN CHINESE WOMEN IN THE USA • T.A. Yen, M. Lahiff, N. Hosang, K. Harley, B. EskenaziABS 4. THE RELATION BETWEEN OUTDOOR AIR POLLUTION AND SUDDEN INFANT DEATH SYNDROME – A POPULATION-BASED CASE-CONTROL STUDY • Y.S. Chang, C.H. Liu, P.N. Tsao, P.S. ChenABS 5. LONGITUDINAL GROWTH OF TURKISH VERY LOW BIRTH WEIGHT INFANTS • S. Sancak, M. Hayran, T. Gursoy, F. OvalıABS 6. FETAL SONOGRAPHIC FINDINGS IN A CONFIRMED CASE OF BECKWITH-WIEDEMANN SYNDROME (BWS • M.D. Ordónez Díaz, M.A. Pino Gálvez, C. De la Cámara Morano, D. Trassierra Molina, M.P. Priego Ruiz, M.J. Párraga Quiles, A.B. López Marmol, J.L. Pérez Navero, M. Miño MoraABS 7. CORD BLOOD PENTRAXIN 3/CD36 IN FETAL MACROSOMIA • T. Boutsikou, K. Germanou, D.D. Briana, M. Boutsikou, N. Athanasopoulos, A. Marmarinos, D. Gourgiotis, A. Malamitsi-PuchnerABS 8. NEWBORN GENETIC SCREENING FOR CONGENITAL CENTRAL HYPOVENTILATION SYNDROME IN 41,152 NEWBORNS • P.C. Kuo, C.C. Hung, Y.N. Su, C.Y. Chen, H.C. Chou, W.S. Hsieh, P.N. TsaoABS 9. OFFSPRING OF DIABETIC MOTHER: THE IMPORTANCE OF MATERNAL GLYCEMIC CONTROL • M. Miñambres Rodríguez, A. Pino Vázquez, C. Villa Francisco, I. Sanz Fernández, M. Brezmes Raposo, L. C. Bermúdez BarrezuetaABS 10. PREVALENCE AND PRENATAL DIAGNOSIS OF CONGENITAL MALFORMATIONS IN A TERTIARY HOSPITAL • M.P. Priego Ruiz, M.D. Ordónez Díaz, M.V. Rodriguez Benitez, D. Trassierra Molina, L. Rueda García, J.L. P

  18. INTRODUCTION: Anticipated changes in the global atmospheric water cycle

    Science.gov (United States)

    Allan, Richard P.; Liepert, Beate G.

    2010-06-01

    intensification of precipitation (O'Gorman and Schneider 2009) and analysis of observed and simulated changes in extreme rainfall for Europe (Lenderink and van Mijgaard 2008) and over tropical oceans by Allan et al (2010) appear to corroborate this. Radiative absorption by water vapour (Previdi 2010, Stephens and Ellis 2008) also provides a thermodynamic feedback on the water cycle, and explains why climate model projections of global precipitation and evaporation of around 1-3% K-1 are muted with respect to the expected 7% K-1 increases in low-level moisture. Climate models achieve dynamical responses through reductions in strength of the Walker circulation (Vecchi et al 2006) and small yet systematic changes in the atmospheric boundary layer over the ocean that modify evaporation (Richter and Xie 2008). A further consequence is anticipated sub-tropical drying (Neelin et al 2006, Chou et al 2007); Allan et al (2010) confirm a decline in dry sub-tropical precipitation while the wet regions become wetter both in model simulations and satellite-based observations. Discrepancies between observed and climate model simulated hydrological response to warming (Wentz et al 2007, Yu and Weller 2007) are of immediate concern in understanding and predicting future responses. Over decadal time-scales it is important to establish whether such discrepancies relate to the observing system, climate modeling deficiencies, or are a statistical artifact of the brevity of the satellite records (Liepert and Previdi 2009). Techniques for extracting information on century-scale changes in precipitation are emerging (Smith et al 2009) but are also subject to severe limitations. Past decadal-scale changes in the water cycle may be further influenced by regionally and temporally varying forcings and resulting feedbacks which must be represented realistically by models (Andrews et al 2009). The radiative impact of aerosols and their indirect effects on clouds and precipitation (Liepert et al 2004) provide

  19. ESTUDIO SOBRE LOS PROCESOS COLABORATIVOS DEL AULA EN ESCUELAS DEMOCRÁTICAS Y COLABORATIVAS: UN PLANTEAMIENTO PARA SU APLICACIÓN EN LA ENSEÑANZA DE LA GEOGRAFÍA

    Directory of Open Access Journals (Sweden)

    Juvenal Padrón Fragoso

    2005-12-01

    reflected in its internal processes that respond in the main to non current expositions that do not bear in mind the new realities - the globalization and the multiculturality - and its requirements. School is not far away fiom al1 this, on the contrary, its role across the curriculum in the reconstruction of a new cultural identity based on the principies of the cooperation and the incorporation is a challenge on which it is necessary to outline the bases of the new school. In this study we try to give to know the perception that the pro- fessorship has with regard to the cooperative dynamics in the centers as response to those new rea- lities and problems. KEY WORDS:School.Globalization, Socialization, Multiculturality, Curriculum, Incorporation, Collaborative professorship, Cooperative learning, Didactic methods, Scholastic culture, Democracy. RESUMÉ:L'école est soumise a de nouveaux problemes, conséquence d'un mode chaque fois plus glo- balisé. Celle-ci vit une grave crise dídentité qui implique des conséquences négatives dans ses objectifs et processus internes. Certaines expectatives sur le role de l'école ont échoué au cours du L'école n'est pas éloignée de tout cela, au contraire, son r6le, a travers de son plan d'étude, dans la reconstruction d'une nouvelle identité culturelle basée sur les principes de la coopération et de l'inclusion, est un défit sur lequel il faut profiler les bases de la nouvelle école. Dans cette étude, nous essayons de faire connaitre la perception du professorat en ce qui concerne les dynamiques coopératives dans les centres comme réponse a ces nouvelles réalités et problemes. MOTS CLE:École. Globalisé, Socialisation, Multiculture, Plan d'étude, Inclusion, Apprentissage coopératif, Professorat de collaboration, Méthodes didactiques, Culture scolaire, Démocratie. 

  20. EDITORIAL: Focus on Micro- and Nanofluidics FOCUS ON MICRO- AND NANOFLUIDICS

    Science.gov (United States)

    Ajdari, Armand; Stone, Howard A.

    2009-07-01

    , simulation and theory, in this rapidly developing field. Focus on Micro- and Nanofluidics Contents The anti-lotus leaf effect in nanohydrodynamic bump arrays Keith Morton, Ophelia K C Tsui, Chih-Kuan Tung, James C Sturm, Stephen Y Chou and Robert Austin Transport in nanofluidic systems: a review of theory and applications W Sparreboom, A van den Berg and J C T Eijkel The effects of polymer molecular weight on filament thinning and drop breakup in microchannels P E Arratia, L-A Cramer, J P Gollub and D J Durian Mass transfer and interfacial properties in two-phase microchannel flows Jeffrey D Martin and Steven D Hudson Temporal response of an initially deflected PDMS channel Priyadarshi Panda, Kai P Yuet, Dhananjay Dendukuri, T Alan Hatton and Patrick S Doyle Gas-liquid two-phase flow patterns in rectangular polymeric microchannels: effect of surface wetting properties D Huh, C-H Kuo, J B Grotberg and S Takayama Mixing via thermocapillary generation of flow patterns inside a microfluidic drop María Luisa Cordero, Hans Olav Rolfsnes, Daniel R Burnham, Paul A Campbell, David McGloin and Charles N Baroud Pressure-driven DNA transport across an artificial nanotopography J T Del Bonis-O'Donnell, W Reisner and D Stein Eulerian indicators for predicting and optimizing mixing quality Rob Sturman and Stephen Wiggins Asymmetric flows over symmetric surfaces: capacitive coupling in induced-charge electro-osmosis T S Mansuripur, A J Pascall and T M Squires High-viscosity fluid threads in weakly diffusive microfluidic systems T Cubaud and T G Mason Interfacial mass transport in steady three-dimensional flows in microchannels Joseph D Kirtland, Corey R Siegel and Abraham D Stroock Active connectors for microfluidic drops on demand Jean-Christophe Galas, Denis Bartolo and Vincent Studer Electrokinetic control of sample splitting at a channel bifurcation using isotachophoresis Alexandre Persat and Juan G Santiago Differential inertial focusing of particles in curved low

  1. Gouvernance de l’eau potable et dynamiques locales en zone rurale au Bénin

    Directory of Open Access Journals (Sweden)

    Bernard G. Hounmenou

    2006-05-01

    Full Text Available Dans la fourniture des services de base aux populations, les politiques publiques de plusieurs pays, en particulier celles des Pays en Voie de Développement (PED, ont connu ces dernières années une profonde mutation. Les changements les plus remarquables se rapportent à la remise en cause du service public gratuit. Outre la nécessité fondamentale pour les Etats d’assainir leurs économies, ces réformes visent à favoriser une participation des populations dans la conduite des opérations ayant pour objectif la satisfaction de leurs besoins. La question de la participation constitue actuellement un élément capital pour l’organisation des services au niveau communautaire. En effet, plusieurs expériences ont montré que les projets réalisés sans la participation des populations concernées ont échoué au moment de l’exécution ou, faute d’entretien, n’ont eu que des retombées éphémères (Banque Mondiale, 1994. Au Bénin, certaines opérations de développement, en particulier celles conduites dans le secteur de l’approvisionnement en eau potable des populations rurales, n’ont pas échappé à cette réalité. En effet, jusqu’à la fin des années 1980, plusieurs ouvrages d’approvisionnement en eau potable ont été construits par les pouvoirs publics, sans une réelle participation des communautés bénéficiaires en milieu rural béninois. Cette situation a occasionné un manque d’intérêt des populations, qui s’est exprimé par l’abandon des ouvrages en cas de panne, et le recours à l’utilisation de sources d’eau non potable. Pour y remédier, le Bénin a opté en 1992 pour une nouvelle stratégie nationale d’alimentation en eau potable. La stratégie a pour objectif l’implication des populations du monde rural dans tout le processus d’appropriation de l’alimentation en eau. Les principes fondamentaux de cette stratégie sont notamment, la décentralisation du processus de prise de d

  2. Un populisme de la misère : Haïti sous la présidence Aristide (1990-2004

    Directory of Open Access Journals (Sweden)

    Laurent Jalabert

    2005-09-01

    Full Text Available Elu en 1990 à l’issue d’un grand mouvement populaire en sa faveur en déclarant vouloir faire passer son pays de la « misère indigne à la pauvreté digne », Jean-Bertrand Aristide a quitté son pays en 2004, 3 ans après une réélection contestée, laissant Haïti dans une situation économique et sociale dégradée. Son exercice du pouvoir s’assimile à un « populisme moderne » qui s’est constitué lentement dans le contexte d’une transition démocratique incertaine. Populiste moderne, il utilise tous les moyens pour rester au pouvoir : corruption, milices de jeunes fanatisés, diabolisation des Etats occidentaux, exhortation du peuple… Il a aussi fait appel aux méthodes habituelles du leader populiste : encadrement de la société par la terreur, les médias, le parti, la fraude électorale, la corruption…. Son échec provient des limites de ses soutiens (milices armées incontrôlables, poids et rôle incertains des mafias de la drogue, division interne à son parti, faiblesse de la police, absence d’armée, isolement international. Dans ce contexte, malgré la terreur imposée aux intellectuels et à l’opposition, il n’a pas su empêcher la montée en puissance des mécontentements. Le peuple, manipulé, n’a plus cru en son Président dès les années 2002-2003. Porté par les masses des bidonvilles au pouvoir, Aristide n’a pas répondu à leur attente. Il s’est mis dans la peau d’un populiste sans imagination. Il a échoué dans tous les domaines, sombrant dans une démagogie et un discours sans prise sur l’opinion. Le régime d’Aristide ne fut qu’un populisme de misère, indigne, pour un peuple digne toujours en quête de démocratie.Jean-Bertrand Aristide había sido elegido presidente en 1990 merced a un gran movimiento popular a su favor, cuando declaraba querer llevar a su país « de la miseria indigna a la pobreza digna ». En el 2004, 3 años después de una reelección pol

  3. The effectiveness of music on pain among preterm infants in the neonatal intensive care unit: a systematic review.

    Science.gov (United States)

    Pölkki, Tarja; Korhonen, Anne

    BA), and music as an auditory stimulus not exceed 75 dB in NICU. If earphones or other devices are used, sound sources should be kept at reasonable distances from the infant's ear, played for brief periods and at levels below 55 dB.Music listening can be initiated with or without the involvement of a music therapist. In this review, music can be implemented for premature infants by a music therapist or any health care providers and it will include both recorded and live music. Regardless of the type of music, several studies have investigated the short term effects of music on preterm infants, including the improvement in physiological outcomes (e.g. oxygen saturation, heart rate, respiratory rate, and blood pressure), as well as in behavioural state (e.g. crying, facial expression, body movements) and pain scores. For example, Chou et al. showed that premature infants receiving recorded music, that was the combination of womb sounds and the mother singing, with endotracheal suctioning had significantly higher oxygen saturation than when they did not receive music. Butt & Kisilewsky compared recorded music involving both the vocal and instrumental version of Brahms lullaby versus no music, and found that infants older than 31 weeks demonstrated significant reduction in heart rate, behavioral state and pain.In the study of Arnon et al. the infants receiving live music, compared with infants receiving recorded music or no music, had significantly reduced heart rate and behavioral scores during the post-intervention period. Live music comprised of a lullaby sang by the female voice with frame drum and an accompanying harp. The same music was played by a tape recorder. Live music showed significant benefits, whereas no statistically significant changes were found for the recorded music and control groups. Teckenberg-Jansson et al. indicated that music therapy combined with kangaroo care decreased the pulse, slowed down the respiration and increased the transcutaneous oxygen

  4. Is immediate imaging important in managing low back pain?

    Science.gov (United States)

    Andersen, J C

    2011-01-01

    Chou R, Fu R, Carrino JA, Deyo RA. Imaging strategies for low-back pain: systematic review and meta-analysis. Lancet. 2009;373(9662):463-472. In patients with low back pain (LBP) who do not have indications of a serious underlying condition, does routine, immediate lumbar imaging result in improved patient outcomes when compared with clinical care without immediate imaging? Studies were identified by searching MEDLINE (1966 through first week of August 2008) and the Cochrane Central Register of Controlled Trials (third quarter of 2008). The reference lists of identified studies were manually reviewed for additional citations. The search terms spine, low-back pain, diagnostic imaging, and randomized controlled trials were used in both databases. The complete search strategy was made available as an online supplement. The search criteria were applied to the articles obtained from the electronic searches and the subsequent manual searches with no language restrictions. This systematic review and meta-analysis included randomized, controlled trials that compared immediate, routine lumbar imaging (or routine provision of imaging findings) with usual clinical care without immediate lumbar imaging (or not routinely providing results of imaging) for LBP without indications of serious underlying conditions. Data extraction and assessment of study quality were well described. The trials assessed one or more of the following outcomes: pain, function, mental health, quality of life, patient satisfaction, and overall patient-reported improvement. Two reviewers independently appraised citations considered potentially relevant, with disagreements between reviewers resolved by consensus. Two independent reviewers abstracted data from the trials and assessed quality with modified Cochrane Back Review Group criteria. The criterion for blinding of patients and providers was excluded because of lack of applicability to imaging studies. In addition, the criterion of co

  5. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Brain and development”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    Full Text Available Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Brain and development”ABS 1. CRITICAL CONDITION OF THE FETUS: RISK FACTORS AND PERINATAL OUTCOMES • E. Timokhina, A. Strizhakov, K. DerishABS 2. A MID-STUDY SAFETY CONTROL IN A HYPOTHERMIA PLUS MELATONIN CLINICAL TRIAL • A. Jerez-Calero, E. Fernandez-Marin, L. Serrano-López, AR. Gonzalez-Ramirez, J. Uberos-Fernandez, E. Narbona-LópezABS 3. EARLY PREDICTORS OF NEURODEVELOPMENTAL OUTCOME IN ASPHYXIATED INFANTS TREATED WITH SELECTIVE HEAD COOLING • C.Y. Chen, P.N. Tsao, H.C. Chou, W.S. HsiehABS 4. PRENATAL SURGERY OF MYELOMENINGOCELE: IS IT WORTH DOING? • H. Villalon, M. Pinto, S. Hosiasson, F. Rybertt, A. Fernandez, D. Tuma, L. Pizarro, C. SilvaABS 5. NEONATAL CEREBRAL SINOVENOUS THROMBOSIS: TWO CASES, TWO DIFFERENT GENE POLYMORPHISMS AND RISK FACTORS • O. Turan, D. Anuk Ince, L. Olcay, T. Sezer, K. Gulleroglu, Z.Y. Çelik, A. EcevitABS 6. DEVELOPMENT OF PREMATURE BORN CHILDREN – WHAT ABOUT LANGUAGE, READING AND WRITING? THE SPEECH AND LANGUAGE PATHOLOGIST’S VIEW • Z. Kolundžić, M. Lenček, A. Šimić Klarić, K. Pavičić DokozaABS 7. CHARACTERISTICS AND DISCHARGE OUTCOMES OF INFANTS UNDERGOING THERAPEUTIC HYPOTHERMIA IN AMERICAN NICUs • K. Ellsworth, M. Harris, M. Ellsworth, W. Carey, A. Spitzer, R. ClarkABS 8. PERINATAL STROKE: A LEADING CAUSE OF SEIZURES IN THE NEONATAL PERIOD. 4 YEAR EXPERIENCE IN A TERTIARY NEONATAL INTENSIVE CARE UNIT • P. Mikrou, S. Hands, E. Mawondo, S.V. Rasiah, M. BorooahABS 9. CARRIER SCREENING FOR FRAGILE X SYNDROME IN TAIWAN FROM 2013 TO 2015 • W.C. Yang, C.C. Hung, Y.N. Su, P.N. TsaoABS 10. LENTICULOSTRIATE VASCULOPATHY IN NEONATES: CASES SERIES REPORT • M.P. Priego-Ruiz, D. Trassierra-Molina, M.P. Jaraba-Caballero, M.D. Ordóñez-Díaz, I.M. Tofé-ValeraABS 11. CONGENITAL HYDROCEPHALUS SECONDARY TO ARACHNOID CYST: CASE REPORT • M.P. Priego-Ruiz, I.M. Tofé-Valera, N

  6. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Brain & Development”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    -ACETYLCYSTEINE AMIDE (NACA REDUCES CELL DEATH AFTER EXPOSURE TO OXIDATIVE STRESS IN A PORCINE EPITHELIAL-LIKE EMBRYONIC EFN-R KIDNEY CELL LINE • T. Benterud, S. Manueldas, L. Pankratov, R. Solberg, A. Nordgren, O.D. Saugstad, L.O. BaumbuschABS 7. MELATONIN-INDUCED IMMUNE CELL RESPONSES IN INFANTS WITH NEONATAL ENCEPHALOPATHY PRE AND POST THERAPEUTIC HYPOTHERMIA TREATMENT • S. Aslam, V. McEneaney, R.W.G. Watson, A. O’Neill, E.J. MolloyABS 8. BLOOD PRESSURE DURING THE IMMEDIATE NEONATES TRANSITION: IS THE MIDDLE ARTERY PRESSURE (MAP RELEVANT FOR THE REGIONAL CEREBRAL OXYGENATION (crSO2? • N. Baik, B. Urlesberger, B. Schwaberger, G. Schmölzer, A. Avian, G. PichlerABS 9. BETWEEN 1993 AND 2012: EVOLUTION OF CEREBRAL PALSY IN PRETERM CHILDREN • M. Bickle Graz, J. Schneider, A.C. TruttmannABS 10. N-ACETYLCYSTEINE AMIDE (NACA MAY HAVE NEUROPROTECTIVE PROPERTIES AFTER PERINATAL ASPHYXIA • T. Benterud, L. Pankratov, R. Solberg, A. Nordgren, L.O. Baumbusch, O.D. SaugstadABS 11. BRAIN INTERSTITIAL PH CHANGES DURING THE SUBACUTE PHASE IN A NEWBORN PIGLET PERINATAL ASPHYXIA MODEL • J. Németh, G. Remzső, V. Tóth-Szűki, F. DomokiABS 12. NEUROPROTECTIVE EFFECT OF REMIFENTANIL ON EXCITOTOXIC-INDUCED BRAIN DAMAGE IN NEONATAL MICE • C. Chollat, F. Tourrel, M. Lecointre, Y. Ramdani, S. Marret, B. Gonzalez, S. JégouABS 13. THE SafeBoosC II TRIAL: REDUCING CEREBRAL HYPOXIA WITHOUT CHANGING EARLY BIOMARKERS OF BRAIN INJURY • A.M. Plomgaard, W. van Oeveren, T.H. Petersen, T. Alderliesten, T. Austin, F. van Bel, M. Benders, O. Claris, E. Dempsey, A. Franz, M. Fumagalli, C. Gluud, C. Hagmann, S. Hyttel-Soerensen, P. Lemmers, A. Pellicer, G. PicABS 14. PREDICTING WHITE MATTER DAMAGE BY EVALUATION OF THE LINEAR GROWTH RATE OF CORPUS CALLOSUM IN VERY LOW BIRTH WEIGHT INFANTS • H. Huang, C. Chen, H. Chou, P. Tsao, W. HsiehABS 15. REGIONAL AND DEVELOPMENTAL SCREENING OF BILIRUBIN TOXICITY: HIPPOCAMPUS IS THE MOST SENSIBLE REGION • M. Dal Ben, C. Tiribelli, S. GazzinABS 16. EFFICACY

  7. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pulmonology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    . Malhotra, K. Tan, G. Woodhead, C.A. Nold-Petry, M.F. NoldABS 40. PRENATAL THERAPY IMPROVES THE SURVIVAL OF PREMATURE INFANTS WITH CONGENITAL CHYLOTHORAX • C.J. Lee, P.N. Tsao, C.Y. Chen, W.S. Hsieh, H.C. ChouABS 41. REFERENCE RANGES OF LAMELLAR BODY COUNTS ON GASTRIC ASPIRATE IN HEALTHY TERM NEWBORNS • S. Arayici, G. Kadioglu Simsek, B. Say, N. Uras, M.Y. Oncel, E. Alyamac Dizdar, U. Buyukkagnici, S. Karahan, F.E. Canpolat, S.S. OguzABS 42. CORD BLOOD PENTRAXIN-3 LEVELS IN RESPIRATORY DISORDERS OF THE NEWBORN • M.O. Arslanoglu, E.C. Dinleyici, N. Tekin, T. Barsan Kaya, O. Aydemir, M.A. AksitABS 43. EVALUATION OF PHYSIOLOGICAL ADAPTATION OF THE LUNG TO POSTNATAL LIFE BY LUNG ULTRASOUND • M. Federici, M.G. Pattumelli, F. Feleppa, C. Gizzi, L. Massenzi, A.M. Giua, S. Sinibaldi, M. Massoud, P.V. FedericiABS 44. NON-INVASIVE MONITORING OF OXYGEN IN THE LUNGS OF NEWBORN INFANTS BY DIODE LASER • M. Larsson, P. Lundin, E. Krite Svanberg, J. Åkeson, K. Svanberg, S. Svanberg, S. Andersson-Engels, V. FellmanABS 45. CELLULAR AGING, MEASURED AS TELOMERE ATTRITION RATE, IS NOT ACCELERATED IN PRETERM INFANTS DURING THE FIRST 18 MONTHS OF LIFE • E. Henckel, Z. Haider, P. Kosma, C. Palme-Kilander, G. Roos, S. Degerman, K. BohlinABS 46. INHALED NITRIC OXIDE DECREASES MORTALITY IN INFANTS LESS THAN 28 WEEKS GESTATION FOLLOWING PRETERM PRELABOUR RUPTURE OF MEMBRANES • S. Pal, G.J. Belteki, G. Vass, T. Ibrahim, P. Clarke, Z. Molnar, Y. Singh, A.E. CurleyABS 47. PLASMA PRO-ENDOTHELIN-1 AND PRO-ATRIAL NATRIURETIC PEPTIDE AS EARLY BIOMARKERS FOR DEVELOPMENT OF BRONCHOPULMONARY DYSPLASIA IN VERY PRETERM INFANTS • R. Gerull, R. Neumann, M. Nelle, S. Schulzke, S. WellmannABS 48. TIMELY IN-HOSPITAL VACCINATION OF VLBW INFANTS REDUCES THE RATE OF BRONCHITIS AFTER DISCHARGE OF VLBW INFANTS • G. Stichtenoth, C. Härtel, E. Herting, W. Göpel; German Neonatal Network (GNNABS 49. A MURINE MODEL OF BRONCHOPULMONARY DYSPLASIA – PRELIMINARY RESULTS FROM WHOLE-GENOME mRNA EXPRESSION STUDY

  8. PREFACE: IARD 2010: The 7th Biennial Conference on Classical and Quantum Relativistic Dynamics of Particles and Fields

    Science.gov (United States)

    Horwitz, Lawrence; Hu, Bei-Lok; Lee, Da-Shin; Gill, Tepper; Land, Martin

    2011-12-01

    relativity. The opening session of IARD 2010 was held jointly with the closing seesion of the RQI-N workshop on relativistic quantum information that took place from 28-30 May. This joint meeting emphasized the importance of including dynamical models in relativistic quantum information theory, and of utilizing the perspective of quantum information in extracting results with strong implications for application in relativistic dynamics. Topics discussed at the conference and reported in this volume included investigations into problems in general relativity, relations between quantum field theory, cosmology and, in its statistical aspects, to the extraction of classical attributes of macroscopic quantum systems. There was also a very fundamental study by David R Finkelstein, of the stucture of spacetime itself, posing the possibility that the spacetime manifold emerges from an underlying quantum complex, composed of simplices with spin 1/2 and Fermi statistics, resulting in the regularization of the Standard Model and perhaps a regularized structure for quantum gravity. H T Cho and B L Hu study the vacuum expectation value of the stress energy tensor of a minimally coupled massless scalar field and its role as a source in the Einstein-Langevin equations of quantum gravity, governing the induced metric of fluctuations above the mean field dynamics of the semiclassical theory. C H Chou, B L Hu and Y Subasi study macroscopic quantum phenomena from the point of view of correlations, coupling and criticality, and explain how a macroscopic quantum system may, in this way, acquire classical attributes but still retain some quantum features. S Y Lin discusses a connection with quantum information science as one of the consequences of his work on local projective measurements on relativistic fields. In the field of cosmology, F H Ho and J M Nester study Poincaré gauge theory with a metric compatible connection to an independent dynamics associated with torsion and curvature. They

  9. El HTLV-I y la PET/HAM un modelo de investigación en virología y biología molecular

    Directory of Open Access Journals (Sweden)

    Felipe García Vallejo

    2004-03-01

    :641-648.

    4. CHÁVEZ M, DOMÍNGUEZ M C, BLANK A, QUINTANA M, EIZURU Y, GARCÍA VALLEJO F. Estudio de la reconstrucción de la evolución molecular de la infección actual por el virus linfotrópico humano tipo I en Colombia. Biomédica. 2004; 24: 20-32.

    5. SOTO L, GARCÍA-VALLEJO F, RENJIFO B, DOMÍNGUEZ M, VERGARA A, ESSEX M. Antibodies in gingival crevicular fluid in patients with tropical spastic paraparesis-HTLV- 1-associated myelopathy (TSP/HAM.Viral Immunology 1995; 8 :141-150.

    6. GARCÍA-VALLEJO F, SOTO L, RENJIFO B, CHOU K, DOMÍNGUEZ M C, ESSEX M.1995. Free human T-cell Leukemia virus type I (HTLV-I RNA templates in sera from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy is correlated with increased titers of IgM and IgA. J AIDS and Hum Retrovirol.10:83.

    7. GARCÍA-VALLEJO F, NARVÁEZ M, DOMÍNGUEZ MC, ZANINOVIC V. Anticuerpos para proteínas de astrositos humanos cultivados in vitro circulantes en el suero de individuos seropositivos para el HTLV-I. Rev. Asoc. Col. Cienc. Biol 2002; 14: 82-90.

    8. GARCÍA-VALLEJO F., TRUJILLO R., DOMÍNGUEZ M., ESSEX M. 1996. Molecular mimicry and its implications in the pathogenesis of TSP HTLV-I-Associated myelopathy. In HTLV. Truths and Questions (Ed. V. Zaninovic. Fundación MAR and COLCIENCIAS. pp. 96-104.

    9. RENJIFO B, SOTO L, GARCÍA-VALLEJO F, ESSEX M. Human T cell leukemia virus type I (HTLV-I molecular genotypes and

  10. PREFACE: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials

    Science.gov (United States)

    Sentein, Carole; Schuster, Frédéric; Tardif, François

    2011-07-01

    . Rochester, USA)David PUI (U. Minnesota, USA)Eric QUEMENEUR (CEA, FR)Robert SCHALLER (EPFL, CH)Carole SENTEIN (CEA, FR)Ken TAKEDA (U. Tokyo, JP)Louis TREPIED (MINEFE, FR)Jacques VENDEL (IRSN, FR)Olivier WITSCHGER (INRS, FR) List of Participants AGUY SCordouan, FR ALLEMAN LEcole des Mines de Douai, FR ALPER MUniv. California Berkeley, US ALVES O LUNICAMP, BR AMDAOUD MUniv. Joseph Fourier, FR AMODEO TINERIS, FR AMYOTTE PDalhousie Univ., CA ARAKELIAN M CFundacion Argentina de Nanotecnologia, AR ARZAMASTSEVA ETomsk Polytechnic Univ., RU ASCHBERGER KEuropean Commission-JRC, IT ASHTON AJPCS, GB ASIMAKOPOULOU ACERTH/CPER, GR AUBLANT J-MLNE, FR AUDE-GARCIA CCEA, FR AUFFAN MCEREGE, FR AUGER ACEA, FR BAEK MSeoul Woman's Univ., KR BAEZA AUniv. Paris 7 Diderot, FR BAGUET DCEA, FR BARONE FIstituto Superiore di Sanità, IT BAU SINRS, FR BELLEVILLE PCEA, FR BENAZET SSNPE-Matériaux Energétiques, FR BERGER L-MFraunhofer Institute, DE BERGES MDGUV-IFA, DE BERNARD CNIST, US BERNARD DARKEMA, FR BERNE PCEA, FR BERRET J-FUniv. Paris 7 Diderot, FR BIGORGNE ECNRS, FR BILLAT BPMS, FR BLOCH DCEA, FR BOGDANOVIC-GUILLON AFreelance journalist, FR BOIVIN DRESPIREX France, FR BOLAND SUniv. Paris 7 Diderot, FR BOMBARDIER PFAURE QEI, FR BORASCHI DInstitute of Biomedical Technologies, IT BOTTERO J-YCEREGE, FR BRADLEY JLux Research, US BREGOLI LVeneto Nanotech, IT BRIGNON J-MINERIS, FR BROCHOT CIRSN, FR BROUWER DTNO Quality of Life, NL BUDIMAN TTSE-Systems, DE CABOCHE JEcole des Mines de Douai, FR CALLET GCEA, FR CALOGINE DINERIS, FR CAPONIGRO ALoreal, FR CARRIERE MCEA, FR CASSETTE SThales Research & Technology, FR CHARPENTIER DINERIS, FR CHEN C-CTaiwan Univ., TW CHEN LHealth Canada, CA CHEVALLET MCEA, FR CHOI S-JSeoul Woman's Univ., KR CHOU C-CChung Cheng University, TW CHUNG H-ESeoul Woman's Univ., KR CIMPAN MUniv. Bergen, NO CIOBANU NTU Munich, DE CLARK KInstitute for Work and Health, CH CONJEAUD HUniv. Paris 7 Diderot, FR COSTA PEREIRA CNational Health Institute, PT CROOKS MTSI, GB CUPERTINO DC

  11. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Pulmonology, Neonatal Respiratory Support, Resuscitation"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    INFANTS • W.A. Gonçalves-Ferri, F.P. Martins-Celini, G.H. Seribeli, E. Sacramento, C. Calixto, M. Bertoldi, D.C. AragonABS 8. CHARACTERIZATION OF PORACTANT ALFA AND BUDESONIDE EXTEMPORANEOUS COM­BINATION FOR SAFE AND EFFECTIVE INTRA­TRACHEAL ADMINISTRATION • F. Ricci, C. Catozzi, F. Ravanetti, F. D’Aló, N. Machidani, E. Sgarbi, V. Di Lallo, F. Saccani, M. Pertile, A. Cacchioli, P. Puccini, S. Catinella, G. Villetti, M. Civelli, F. Amadei, G. Aquino, F.F. Stellari, B. Pioselli, F. SalomoneABS 9. LENGTH OF MECHANICAL VENTILATION AND CLINICAL FEATURES AT BIRTH IN PREMA­TURE INFANTS • A.M. Nakato, R.P.G.V.C. Silva, N. Rosario FilhoABS 10. CONGENITAL LOBAR EMPHYSEMA MIS­DIAG­NOSED AS PNEUMOTHORAX • I. Bakalli, E. Kola, R. Lluka, E. Celaj, D. Sala, I. Gjeta, S. SallabandaABS 11. SECRETORY PHOSPHOLIPASE A2 AND IN­FLAMMATION PROFILE IN PRETERM BABIES WITH RDS RECEIVING ONE OR MULTIPLE SURFACTANT DOSES • S. Shankar-Aguilera, C. Fitting, L. Vedovelli, V. Dell’Orto, V.P. Carnielli, L. Touqui, D. De Luca, M. SimonatoABS 12. SURFACTANT ADMINISTRATION AND NON-INVASIVE VENTILATION IN SURFACTANT DEFICIENCY NEWBORN PIGLETS • C. Rey-Santano, V. Mielgo, M. Gomez-Solaetxe, F. Ricci, F. Bianco, F. Salomone, B. Loureiro, J. López-de-HerediaABS 13. THE EFFECT OF MINIMALLY INVASIVE SURFACTANT THERAPY ON DIAPHRAGMATIC ACTIVITY • C.G. de Waal, G.J. Hutten, F.H.C. de Jongh, A.H.L.C. van KaamABS 14. RELIABILITY AND ACCURACY OF PULSE OXIMETRY TO DETERMINE SaO2 AND PaO2 IN PRETERM INFANTS • D. Wackernagel, M. Blennow, A. HellströmABS 15. CAN WE ASSESS THE SEVERITY OF NEONATAL RESPIRATORY DISTRESS BY ULTRASOUND? A COMPARISON OF THREE METHODS • F. Raimondi, F. Migliaro, L. Verdoliva, D. Gragnaniello, G. Poggi, C. Sansone, R. Kosova, L. CapassoABS 16. MATERNAL PREECLAMPSIA AND THE RISK OF RESPIRATORY DISTRESS SYNDROME IN VLBW INFANTS • T.A. Yen, Y.H. Wen, H.I. Yang, W.S. Hsieh, H.C. Chou, C.Y. Chen, K.I. Tsou, P.N. TsaoABS 17. EFFECT OF COMMERCIALLY AVAILABLE SUR