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Sample records for hui-chen chou pi-hua

  1. An Survey of the Hui Chen You's Family During the Ming Dynasty%明朝回回人陈友家族考述

    Institute of Scientific and Technical Information of China (English)

    陈亮

    2012-01-01

    有明一代,涌现出一大批著名的回回军事家、政治家、外交家等等,他们对明朝的巩固与发展作出了巨大贡献和牺牲。"西域回回"陈友以出使起家,后因军功封为世爵,成为明朝回回人当中的标志性人物。对陈友个人及其家族成员的事迹考述,对研究明代回回人的历史活动以及历史作用有重要的价值。%During the Ming dynasty, there emerged many notable Hui militarists, politicians and diplomats who made a number of contributions at personal sacrifice in order to further the consolidation and development of the country. As a Serindia Hui, Chen You got his start from a career as a diplomat and was offered a marquis title on the basis of his military exploits. During the Ming Dynasty, he became an iconic figure amongst the Hui. Through this historical survey of Chen You and his family, we see the significant value he has with regard towards the histori- cal activity and influence of the Hui during the Ming dynasty.

  2. Chou-Yang model and PHI form factor

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem; Saleem, M.; Rafique, M.

    1988-03-01

    By using the deduced differential cross-section data for PHIp elastic scattering at 175 GeV/c in the Chou-Yang model, the PHI form factor has been computed and parametrized. Then in conjunction with the proton form factor this form factor is used in the pristine Chou-Yang model to obtain differential cross-section data at Fermilab energies. The theoretical results agree with the experimental measurements, endorsing the conjecture that the hadronic form factor of neutral particle is proportional to its magnetic form factor.

  3. Generalised Chou-Yang model and recent results

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem [International Centre for Theoretical Physics, Trieste (Italy); Rashid, H. [Punjab Univ., Lahore (Pakistan). Centre for High Energy Physics

    1996-12-31

    It is shown that most recent results of E710 and UA4/2 collaboration for the total cross section and {rho} together with earlier measurements give good agreement with measurements for the differential cross section at 546 and 1800 GeV within the framework of Generalised Chou-Yang model. These results are also compared with the predictions of other models. (author) 16 refs.

  4. Generalized Chou-Yang Model and Meson-Proton Elastic Scattering at High Energies

    Science.gov (United States)

    Saleem, Mohammad; Aleem, Fazal-E.; Rashid, Haris

    The various characteristics of meson-proton elastic scattering at high energies are explained by using the generalized Chou-Yang model which takes into consideration the anisotropic scattering of objects constituting pions(kaons) and protons. A new parametrization of the proton form factor consistent with the recent experimental data is proposed. It is then shown that all the data for meson-proton elastic scattering at 200 and 250 GeV/c are in agreement with theoretical computations. The physical picture of generalized Chou-Yang model which is based on multiple scattering theory is given in detail.

  5. Generalized Chou-Yang model and meson-proton elastic scattering at high energies

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Aleem, F.E.; Rashid, H.

    1989-01-01

    The various characteristics of meson-proton elastic scattering at high energies are explained by using the generalized Chou-Yang model which takes into consideration the anisotropic scattering of objects constituting pions(kaons) and protons. A new parametrization of the proton form factor consistent with the recent experimental data is proposed. It is then shown that all the data for meson-proton elastic scattering at 200 and 250 GeV/c are in agreement with theoretical computations. The physical picture of generalized Chou-Yang model which is based on multiple scattering theory is given in detail.

  6. Generalized Chou-Yang model for p(antip)p and. lambda. (anti. lambda. )p elastic scattering at high energies

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Fazal-E-Aleem; Azhar, I.A.

    1988-06-01

    The various characteristics of pp and antipp elastic scattering at high energies are explained by using the generalized Chou-Yang model which takes into consideration the anisotropic scattering of objects constituting colliding particles. The model is also used to extract the form factor and radius of the ..lambda.. particle.

  7. Spatial distribution of soil erosion and suspended sediment transport rate for Chou-Shui river basin

    Indian Academy of Sciences (India)

    Chin-Ping Lin; Ching-Nuo Chen; Yu-Min Wang; Chih-Heng Tsai; Chang-Tai Tsai

    2014-10-01

    In this study, a Physiographic Soil Erosion–Deposition Model (PSED) is applied for better management of a watershed. The PSED model can effectively evaluate the key parameters of watershed management: surface runoff discharge, suspended sediment transport rate, quantity of soil erosion, and spatial distribution of soil erosion and deposition. A basin usually contains multiple watersheds. These watersheds may have complex topography and heterogeneous physiographic properties. The PSED model, containing a physiographic rainfall-runoff model and a basin scale erosion–deposition model, can simulate the physical mechanism of the entire erosion process based on a detailed calculation of bed-load transportation, surface soil entrainment, and the deposition mechanism. With the assistance of Geographic Information Systems (GIS), the PSED model can handle and analyze extremely large hydrologic and physiographic datasets and simulate the physical erosion process without the need for simplification. We verified the PSED model using three typhoon events and 40 rainfall events. The application of PSED to Chou-Shui River basin shows that the PSED model can accurately estimate discharge hydrographs, suspended sediment transport rates, and sediment yield. Additionally, we obtained reasonable quantities of soil erosion as well as the spatial distribution of soil erosion and deposition. The results show that the PSED model is capable of calculating spatially distributed soil erosion and suspended sediment transport rates for a basin with multiple watersheds even if these watersheds have complex topography and heterogeneous physiographic properties.

  8. Dehydriding reaction kinetic mechanism of MgH2-Nb2O5 by Chou model

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Chou model was used to investigate the dehydriding reaction kinetic mechanism of MgH2-Nb2O5 hydrogen storage materials at 573 K.A new conception,"characteristic absorption/desorption time(yc)"was introduced to characterize the reaction rate.The fitting results show that for the hydrogen desorbing mechanism.the surface penetration iS the rate.controlling step.The mechanism remains the same even when the original particle size of Nb2O5 is before ball milling(BM)or when the BM time changes.And tc indicates that the desorption rate of MgH2-Nb2O5 will be faster than that of MgH2-Nb2O5 by BM.The dehydriding reaction rate of MgH2-Nb2O5(micro particle)BMed for 50 h is 4.76 times faster than that of the MgH2-Nb2O5(micro particle)BMed for 0.25 h,while the dehydriding reaction rate of MgH2-Nb2O5(nano particle)BMed for 50 h is only 1.1 8 times as that of the MgH2-Nb2O5 (nano particle)BMed for 0.25 h.The dehydriding reaction rate of the BMed MgH2-Nb2O5(nano particle)is 1-9 times faster than that of the BMed MgH2-Nb2O5(micro particle).

  9. Characterization and hepatoprotective effect of polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp.

    Science.gov (United States)

    Yue, Yuan; Wu, Shuangchan; Zhang, Huifang; Zhang, Xuyan; Niu, Yunhui; Cao, Xiaoqin; Huang, Fuwei; Ding, Hong

    2014-12-01

    The polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp (PWJS) is evaluated for the chemical composition, antioxidant activity and hepatoprotective effect. The characteristics of PWJS were determined by FT-IR spectral and HPLC analysis. The antioxidant activity was investigated using in vitro systems. An in vivo study of PWJS against CCl4 induced liver injury was also conducted. HPLC analysis showed that PWJS is an acidic heteropolysaccharide, rich in glucose (38.59%), arabinose (23.16%), galacturonic acid (17.64%) and galactose (10.44%). PWJS displayed strong antioxidant activity in vitro. In the in vivo study, PWJS treatment lowered the serum levels of ALT and AST in CCl4-intoxicated mice. Additionally, levels of antioxidant enzymes (SOD and CAT) and GSH were elevated in liver damage mice by PWJS intervention, while content of MDA was lessened. Meanwhile, PWJS reverses the suppression of Nrf2 nuclear translocation, and increases the protein expression of HO-1, GSTα and NQO1 in liver damage mice. Hematoxylin-eosin staining showed that the condition of liver damage was mitigated. This study demonstrates that PWJS reverses hepatotoxicity in CCl4-intoxicated mice through the mechanisms of antioxidant activity, as well as an augmentation of the Nrf2 pathway in liver tissue.

  10. Anti-pp,. cap alpha cap alpha. and p. cap alpha. elastic scattering at high energies and Chou-Yang conjecture

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Fazal-e-Aleem; Rifique, M.

    1987-03-01

    The recent experimental measurements for anti-pp and ..cap alpha cap alpha.. elastic scattering at high energies have shown that the Chou-Yang conjecture regarding the relationship between the electromagnetic and the hadronic form factor of a particle is only an approximation. A new ansatz has been proposed to obtain hadronic form factors of proton and the ..cap alpha..-particle. These form factors have been used to explain the various characteristics of anti-pp, ..cap alpha cap alpha.. and p..cap alpha.. elastic scattering at high energies.

  11. Siegen K.Chou's Military Psychological Practices and Thoughts During the War of Resistance Against Japan%抗战时期周先庚的军事心理学实践与思想

    Institute of Scientific and Technical Information of China (English)

    阎书昌; 陈晶; 张红梅

    2012-01-01

    周先庚在汉字心理学、教育心理学和工业心理学等多个领域做出了重要学术贡献或进行了开创性研究,但是他在抗日战争时期军事心理学领域的贡献至今未能获得心理学界的深入认识.周先庚自1943年末开始在国民党第五军中筹办军官心理测验所,从事军官心理测验工作.自1945年4月开始与主题统觉测验创始人默里合作从事伞兵选拔心理测评工作.在开展军事心理学实践的过程中,周先庚提出了“创造中国本位军事心理学”的主张.周先庚在与默里开展的军事心理学合作中建立了深厚的友谊.周先庚将心理学知识用于抗日军官、伞兵的选拔上,既体现了他的抗日精神,也体现了他的实践精神、开创精神和中国本位精神.%Siegen K. Chou (a.k.a. Zhou XianGeng), a modern Chinese psychologist, has made a lot of important contributions to the development of Chinese character psychology, educational psychology, industrial psychology etc. in China. However, Chou's contributions to the development of Chinese military psychology has never been recognized in the world of psychology in China. At the end of 1943, Chou was invited by Qiu Qingquan, a famous Kuomintang (KMT) general, to help set up an institute to do psychological testing to army officers. Since he accepted Qiu's invitation, Chou designed a draft plan for the institute, including planning procedure, nature and objectives, methodology, organization and propaganda, etc.. The series of work initiated the modern military psychology in China. For various reasons, although the institute had been prepared for a little more than 15 months, it didn't do any practical psychological testing. In March, 1945, Henry A. Murray came to China to take charge of recruiting pilot candidates for Chinese army. He invited Chou to join his assessment group. Chou learned Murray's testing methods systematically during their collaboration, and they had established

  12. Evidence of syntectonic tephrites with nepheline in the Sidi Saïd Maâchou Cambrian basin (coastal Meseta, Morocco; geodynamic implications

    Directory of Open Access Journals (Sweden)

    El Hatimi, N.

    2009-12-01

    Full Text Available Based on a combined structural, petrographic, and geochemical analysis, a new interpretation of the basic magmatism of Sidi Saïd Maâchou (coastal Meseta in two stages of emplacement is proposed. The first stage is characterized by transitional pyroclastic flows that have accompanied the opening of the West-Mesetian basin, during the Cambrian; the second stage is made of dykes of basalts, dolerites, and tephrites bearing nepheline. The emplacement of this undersaturated alkaline magma is associated to a sinistral submeridian shear zone which has been activated at the end of the Caledonian orogenesis, by a mantellic advection.

    Basée sur des critères structuraux, pétrographiques et géochimiques, une réinterprétation du magmatisme basique de Sidi Saîd Maâchou (meseta côtière en deux stades de mise en place est proposée. Le premier stade est caractérisé par des coulées pyroclastiques transitionnelles accompagnant l’ouverture du bassin ouest mésétien au Cambrien. Le second stade, de nature fissural, comprend des basaltes, dolérites et téphrites à néphéline spécifiques d’un magmatisme alcalin sous-saturé. La mise en place de ce dernier est associée à un couloir de cisaillement senestre subméridien activé à la fin de l’orogenèse calédonienne, engendrant un flux géothermique élevé.

  13. A Study on the Triangular Relationship among Later Chou Chi, Northern Wei and Liu Song Dynasty%论后仇池国与刘宋、北魏的三角关系

    Institute of Scientific and Technical Information of China (English)

    张士伟

    2014-01-01

    During the period of the Wei, Jin, Northern and Southern dynasties, Later Chou Chi Dynasty was founded by Yang Ding of Di nationality in the Southeast present Gansu Province. Since it was between two forces of Northern Wei and Liu Song Dynasty, in order to survive, Later Chou Chi Dynasty had to submit to them and be quick to switch sides. The purpose was to be the third party benefiting from the tussle and strengthening its own forces. Northern Wei and Liu Song Dynasty tried to co-opt Later Chou Chi Dynasty and implemented a Jimi policy on it in order to suppress each other. Faced with natural disasters, two wars were launched by Later Chou Chi Dynasty on Liu Song Dynasty but failed and led to the demise of the Dynasty.%魏晋南北朝时,氐族杨定建立的后仇池国位于今甘肃省东南部,处于北魏和刘宋两大势力的夹缝中。为了生存发展,后仇池国分别对这两大势力奉表称臣,过着朝秦暮楚的生活,其目的就是想东食西宿、左右逢源,趁机壮大自己的势力。北魏和刘宋为了相互钳制对方,也尽力拉拢后仇池国,对其实行羁縻政策,双方甚至为争夺仇池而大动干戈,进行了你死我活的斗争。为灾荒所逼,后仇池国两次对刘宋发动战争,结果招来灭顶之灾。

  14. 艺术传播与流行音乐--以周杰伦歌曲创作为例%Art Communication and Popular Music---A Study of Jay Chou ’ s Composition

    Institute of Scientific and Technical Information of China (English)

    邓晓红

    2013-01-01

    Popular music , as an important category of contemporary art , its communication means are totally different from the ones in traditional society .The effect of art communication in modern commercial society is not simply deter-mined by the level of art , but also influenced by communication means and communication skills .The popularity of Jay Chou ’ s composition is a classic case of the modern art .His success derives from his musical talent , sense of innovation , the ability of capturing young people ’ s emotional characteristics and appreciation habits and then integrating them into his creation .Meanwhile , Yang Junrong , his music broker ’ s excellent business operation is an indispensable factor to his success .%流行音乐作为当代艺术的一个重要门类,其传播方式和手段与传统社会大相径庭。现代商业社会的艺术传播,其效果不只是单纯由艺术水平来决定,而是由传播手段、传播方式与传播技巧等各种因素共同作用的结果。周杰伦歌曲创作的流行不失为现代艺术传播的经典案例。他的成功,除了他的音乐天赋之外,还在于他的创新意识,并善于体味和捕捉同时代年轻人的情感特点和欣赏习惯,将其融入自己的创作之中。同时其经纪人杨峻荣出色的商业运作,也是他获得巨大成功不可或缺的因素。

  15. 优质护理示范工程在临床中的应用%Clinical Application of High Quality Nursing Demonstration Project/HUANG Hui,CHEN Li,GUO Zi-yun.//Medical Innovation of China,2012,9(25):041-043

    Institute of Scientific and Technical Information of China (English)

    黄蕙; 陈丽; 郭子云

    2012-01-01

      目的:探讨创建优质护理示范病房的方法与成效.方法:先后确立6个科室为试点病房,从改变护理服务理念和护理工作模式,增强护理人力资源、加强基础护理、落实“护士床边工作制”、强化健康教育,评估护理服务效果,完善绩效考核制度等方面进行探索,创建和完善优质护理示范病房.结果:实施优质护理服务后,患者对护士工作满意度由90.88%上升到99.83%;呼叫率由66.85%下降到16.36%;陪护率及自聘护工率由97.56%下降到69.26%;患者对健康知识知晓率由82.36%上升到97.58%;护士自我满意度由79.08%提高到了93.02%;医生对护士工作的满意度由76.06%提高到了94.05%;无投诉率及护理并发症的发生.结论:通过创建优质护理示范病房,可以提高患者、家属、医护人员的满意度,提高整体护理质量,达到患者、社会和政府三满意.%  Objective: To explore the methods and effectiveness of creating high-quality care demonstration ward.Method:Has established six departments for the pilot unit to change the philosophy of care services and the mode of care,enhancing nursing human resources,strengthening basic care,the implementation of the nurse bedside working to strengthen health education,assess the effect of nursing services,and improve the performance appraisal system and other aspects to explore,create and improve quality care demonstration ward.Result:Patients after the implementation of the job satisfaction of nurses has increased by 90.88% to 99.83%;call rate down from 66.85% to 16.36%;accompanying rate and self-employed care workers decreased from 97.56% to 69.26%;patients health awareness rate increased from 82.36% to 97.58%;nurse self-satisfaction from 79.08% to 93.02%;doctor’s nurses work satisfaction increased from 76.06% to 94.05%;complaints and care the incidence of complications.Conclusion:By creating high-quality care demonstration wards so that patients,their families,medical staff satisfaction improved significantly improve the overall quality of care to patients,society and government three satisfaction.

  16. The Origins of "Exchange Indexing" and "Reindexing" --With a Study of Wang Chongmin' s Jiao Chou Tong Yi Tong Jie%“互著”、“别裁”起源时间考辨——读王重民先生《校雠通义通解》

    Institute of Scientific and Technical Information of China (English)

    李景文

    2012-01-01

    In regard to the origins of two bibliographic methods "exchange indexing" and "" reindexing'", there always exists many bifurcations. This paper intends to tease out the opinions existent in the academic circles, put special emphasis on anatomizing the inductions and analysis of Wang Chongmin in his book Jiao Chou Tong Yi Tong Jie, check and discern the historical context in which "exchange indexing" and "reindexing" came into being, and indicate the viewpoint that "exchange indexing" and "reindexing" originate from Lin Xin is unassailable.%指出关于“互著”、“别裁”这两种文献著录方法的起源问题,历来就有诸多分歧。梳理学界现存的种种观点,尤其是剖析王重民先生在《校雠通义通解》中的归纳与分析,考辨“互著”、“别裁”产生的历史背景,并指出两者起源于刘歆的观点是不容置疑的。

  17. On Physical Appearance and Comic Performances——Theatrical Forms of Jing and Chou Roles in Zaju of Yuan Dynasty%形貌与滑稽论略——兼说元杂剧净、丑脚色的表演形态

    Institute of Scientific and Technical Information of China (English)

    张本一

    2012-01-01

    The burlesque at the early stage is mainly performed by actors with unusual physical appear- ance, with the major form of humorous irony and satire. Since the Tang Dynasty, other types of comic performances have been created including the opera with songs and dances, stories of joining the army and those with acting officials. In the Song Dynasty, this kind of performances is enriched in both content and form, as a result of which zaju (poetic drama set to music) is produced with roles of fumo and fu- ring taking over the priority. The zaju of Yuan Dynasty absorbs the roles of fujing into ring (actors with painted faces) and chou (clowns), which are endowed with certain cultural connotations.%以形貌为滑稽的早期形式主要是谈谐,上古俳优常以特异之形貌微言讽谏;唐代开始,模情拟态的滑稽表演出现了滑稽歌舞戏、参军戏、假官戏、合生等艺术形式;宋代,此类滑稽表演的内容丰富,形式多样,形成了以副末、副净打调为主的宋杂剧艺术形态;副净又被元杂剧净、丑脚色所吸收,并赋予了特定的文化内涵。

  18. 影响公益众筹中项目筹款能力的一些相关因素--以众筹网为例%Some Related Factors Affecting the Ability to Raise Funds in the Crowdfunding of the Public Service---A Case Study of the ZhongChou Network

    Institute of Scientific and Technical Information of China (English)

    苟爱萍; 田江

    2016-01-01

    随着众筹融资和“互联网+”的发展,公益众筹开始兴起,文中通过爬虫软件获取了截至2016年6月22日众筹网所有成功结束的筹款项目的数据,通过数据分析发现了不同性质的公益项目在众筹过程中具有不同的优势,并且通过SPSS进行了数据间简单的相关性分析,发现了影响公益众筹能力的一些相关性因素和非相关因素,研究了项目信息的透明度,回报捐助的方式以及关注度对一个公益筹款项目的影响。%With the development of the Crowdfunding and“Internet plus”,the Crowdfunding of the public service begin to develop.This paper achieved all the datas of the successful public service projects in the ZhongChou network until June 22,2016 using the crawler software.Through the data analysis found that the different nature of the public service projects in the process of raising the fund has a different advantage,and through the simple correlation analysis using SPSS,found some related factors and non-related factors that affect the ability to raise fund in Crowdfunding of the public service,the influence of the transparency of project information,the way of return and the degree of concern on a public service project.

  19. Identification of immunoglobulins using Chou's pseudo amino acid composition with feature selection technique.

    Science.gov (United States)

    Tang, Hua; Chen, Wei; Lin, Hao

    2016-04-01

    Immunoglobulins, also called antibodies, are a group of cell surface proteins which are produced by the immune system in response to the presence of a foreign substance (called antigen). They play key roles in many medical, diagnostic and biotechnological applications. Correct identification of immunoglobulins is crucial to the comprehension of humoral immune function. With the avalanche of protein sequences identified in postgenomic age, it is highly desirable to develop computational methods to timely identify immunoglobulins. In view of this, we designed a predictor called "IGPred" by formulating protein sequences with the pseudo amino acid composition into which nine physiochemical properties of amino acids were incorporated. Jackknife cross-validated results showed that 96.3% of immunoglobulins and 97.5% of non-immunoglobulins can be correctly predicted, indicating that IGPred holds very high potential to become a useful tool for antibody analysis. For the convenience of most experimental scientists, a web-server for IGPred was established at http://lin.uestc.edu.cn/server/IGPred. We believe that the web-server will become a powerful tool to study immunoglobulins and to guide related experimental validations.

  20. Multi-kernel transfer learning based on Chou's PseAAC formulation for protein submitochondria localization.

    Science.gov (United States)

    Mei, Suyu

    2012-01-21

    Protein sub-organelle localization, e.g. submitochondria, seems more challenging than general protein subcellular localization, because the determination of protein's micro-level localization within organelle by fluorescent imaging technique would face up with more difficulties. Up to present, there are far few computational methods for protein submitochondria localization, and the existing sequence-based predictive models demonstrate moderate or unsatisfactory performance. Recent researches have demonstrated that gene ontology (GO) is a convincingly effective protein feature for protein subcellular localization. However, the GO information may not be available for novel proteins or sparsely annotated protein subfamilies. In allusion to the problem, we transfer the homology's GO information to the target protein and propose a multi-kernel transfer learning model for protein submitochondria localization (MK-TLM), which substantially extends our previously published work (gene ontology based transfer learning model for protein subcellular localization, GO-TLM). To reduce the risk of performance overestimation, we conduct a more comprehensive survey of the model performance in optimistic case, moderate case and pessimistic case according to the abundance of target protein's GO information. The experiments on submitochondria benchmark datasets show that MK-TLM significantly outperforms the baseline models, and demonstrates excellent performance for novel mitochondria proteins and those mitochondria proteins that belong to the subfamily we know little about.

  1. PECM: prediction of extracellular matrix proteins using the concept of Chou's pseudo amino acid composition.

    Science.gov (United States)

    Zhang, Jian; Sun, Pingping; Zhao, Xiaowei; Ma, Zhiqiang

    2014-12-21

    The extracellular matrix proteins (ECMs) are widely found in the tissues of multicellular organisms. They consist of various secreted proteins, mainly polysaccharides and glycoproteins. The ECMs involve the exchange of materials and information between resident cells and the external environment. Accurate identification of ECMs is a significant step in understanding the evolution of cancer as well as promises wide range of potential applications in therapeutic targets or diagnostic markers. In this paper, an accurate computational method named PECM is proposed for identifying ECMs. Here, we explore various sequence-derived discriminative features including evolutionary information, predicted secondary structure, and physicochemical properties. Rather than simply combining the features which may bring information redundancy and unwanted noises, we use Fisher-Markov selector and incremental feature selection approach to search the optimal feature subsets. Then, we train our model by the technique of support vector machine (SVM). PECM achieves good prediction performance with the ACC scores about 86% and 90% on testing and independent datasets, which are competitive with the state-of-the-art ECMs prediction tools. A web-server named PECM which implements the proposed approach is freely available at http://59.73.198.144:8088/PECM/.

  2. Pourquoi les Alamans ont échoué face aux Francs

    OpenAIRE

    Geuenich, Dieter

    2012-01-01

    L’article s’efforce de répondre à la question : pourquoi sont-ce les Francs qui ont repris l’héritage de l’Empire romain et non pas les Alamans? Pour quelles raisons, à l’époque de Clovis et de Théodoric, les Alamans n’ont-ils pas joué de rôle déterminant dans le rapport de forces des puissances qui s’efforcent alors de restructurer l’avenir de l’Europe? Doit-on attribuer ce fait à leur infériorité militaire qui scelle leur destin dans ce qu’on a appelé la « bataille décisive de Tolbiac »? Ad...

  3. Novel Technique for Safe Primary Trocar Insertion in Laparoscopy: Chou's Method

    Directory of Open Access Journals (Sweden)

    Pan-Hsin Chou

    2005-06-01

    Conclusion: The results with this novel method incorporating the unique concept of directly holding the fascia suggest it to be relatively safe, simple, and economic. The risk of major vascular injury was decreased to nil by this technique and the chance of visceral injury was also minimal.

  4. Insecticidal toxicities of carvacrol and thymol derived from Thymus vulgaris Lin. against Pochazia shantungensis Chou & Lu., newly recorded pest

    Science.gov (United States)

    Park, Jun-Hwan; Jeon, Ye-Jin; Lee, Chi-Hoon; Chung, Namhyun; Lee, Hoi-Seon

    2017-01-01

    The insecticidal toxicities of five essential oils against Pochazia shantungensis adults and nymphs, newly recorded pests, were evaluated. The LC50 values of Thymus vulgaris, Ruta graveolens, Citrus aurantium, Leptospermum petersonii and Achillea millefolium oils were recorded as 57.48, 84.44, 92.58, 113.26 and 125.78 mg/L, respectively, against P. shantungensis nymphs using the leaf dipping bioassay, and 75.80, 109.86, 113.26, 145.06 and 153.74 mg/L, respectively, against P. shantungensis adults using the spray bioassay method. Regarding volatile components identified in T. vulgaris oil, the LC50 values of carvacrol and thymol using the leaf dipping bioassay against P. shantungensis nymphs were 56.74 and 28.52 mg/L, respectively. The insecticidal action of T. vulgaris oil against P. shantungensis could be attributed to carvacrol and thymol. Based on the structure-toxicity relationship between thymol analogs and insecticidal toxicities against P. shantungensis nymphs similar to the LC50 values against P. shantungensis adults, the LC50 values of thymol, carvacrol, citral, 2-isopropylphenol, 3-isopropylphenol, and 4-isopropylphenol were 28.52, 56.74 and 89.12, 71.41, 82.49, and 111.28 mg/L, respectively. These results indicate that the insecticidal mode of action of thymol analogs may be largely attributed to the methyl functional group. Thymol analogues have promising potential as first-choice insecticides against P. shantungensis adults and nymphs.

  5. Drinking Water Quality Criterion - Based site Selection of Aquifer Storage and Recovery Scheme in Chou-Shui River Alluvial Fan

    Science.gov (United States)

    Huang, H. E.; Liang, C. P.; Jang, C. S.; Chen, J. S.

    2015-12-01

    Land subsidence due to groundwater exploitation is an urgent environmental problem in Choushui river alluvial fan in Taiwan. Aquifer storage and recovery (ASR), where excess surface water is injected into subsurface aquifers for later recovery, is one promising strategy for managing surplus water and may overcome water shortages. The performance of an ASR scheme is generally evaluated in terms of recovery efficiency, which is defined as percentage of water injected in to a system in an ASR site that fulfills the targeted water quality criterion. Site selection of an ASR scheme typically faces great challenges, due to the spatial variability of groundwater quality and hydrogeological condition. This study proposes a novel method for the ASR site selection based on drinking quality criterion. Simplified groundwater flow and contaminant transport model spatial distributions of the recovery efficiency with the help of the groundwater quality, hydrological condition, ASR operation. The results of this study may provide government administrator for establishing reliable ASR scheme.

  6. Simultaneously Identify Three Different Attributes of Proteins by Fusing their Three Different Modes of Chou's Pseudo Amino Acid Compositions.

    Science.gov (United States)

    Huang, Chao; Yuan, Jing-Qi

    2015-01-01

    Most published articles always applied a certain model or arithmetic to only a certain dataset. Considering the avalanche of biological data created in the post-genomic age, this type of research shows many shortcomings and inefficient characteristics, because it is always have difficulties to apply the same model to different datasets. So we proposed a multifunctional ensemble classifier which combines several individual classifiers. Each of them was trained in different parameter system. The final outcomes were combined through a weighted voting system. This classifier was conducted on several strictly constructed biological datasets. Based on the testing result from three different types of biological dataset, this new predictor can deal with more sweeping range of biological data, and receives more efficient and robust results in comparison with other published methods tentatively.

  7. Using the concept of Chou's pseudo amino acid composition to predict protein solubility: an approach with entropies in information theory.

    Science.gov (United States)

    Xiaohui, Niu; Nana, Li; Jingbo, Xia; Dingyan, Chen; Yuehua, Peng; Yang, Xiao; Weiquan, Wei; Dongming, Wang; Zengzhen, Wang

    2013-09-07

    Protein solubility plays a major role and has strong implication in the proteomics. Predicting the propensity of a protein to be soluble or to form inclusion body is a fundamental and not fairly resolved problem. In order to predict the protein solubility, almost 10,000 protein sequences were downloaded from NCBI. Then the sequences were eliminated for the high homologous similarity by CD-HIT. Thus, there were 5692 sequences remained. Based on protein sequences, amino acid and dipeptide compositions were generally extracted to predict protein solubility. In this study, the entropy in information theory was introduced as another predictive factor in the model. Experiments involving nine different feature vector combinations, including the above-mentioned three kinds of factors, were conducted with support vector machines (SVMs) as prediction engine. Each combination was evaluated by re-substitution test and 10-fold cross-validation test. According to the evaluation results, the accuracies and Matthew's Correlation Coefficient (MCC) values were boosted by the introduction of the entropy. The best combination was the one with amino acid, dipeptide compositions and their entropies. Its accuracy reached 90.34% and Matthew's Correlation Coefficient (MCC) value was 0.7494 in re-substitution test, while 88.12% and 0.7945 respectively for 10-fold cross-validation. In conclusion, the introduction of the entropy significantly improved the performance of the predictive method. Copyright © 2013. Published by Elsevier Ltd.

  8. Insecticidal toxicities of carvacrol and thymol derived from Thymus vulgaris Lin. against Pochazia shantungensis Chou & Lu., newly recorded pest

    Science.gov (United States)

    Park, Jun-Hwan; Jeon, Ye-Jin; Lee, Chi-Hoon; Chung, Namhyun; Lee, Hoi-Seon

    2017-01-01

    The insecticidal toxicities of five essential oils against Pochazia shantungensis adults and nymphs, newly recorded pests, were evaluated. The LC50 values of Thymus vulgaris, Ruta graveolens, Citrus aurantium, Leptospermum petersonii and Achillea millefolium oils were recorded as 57.48, 84.44, 92.58, 113.26 and 125.78 mg/L, respectively, against P. shantungensis nymphs using the leaf dipping bioassay, and 75.80, 109.86, 113.26, 145.06 and 153.74 mg/L, respectively, against P. shantungensis adults using the spray bioassay method. Regarding volatile components identified in T. vulgaris oil, the LC50 values of carvacrol and thymol using the leaf dipping bioassay against P. shantungensis nymphs were 56.74 and 28.52 mg/L, respectively. The insecticidal action of T. vulgaris oil against P. shantungensis could be attributed to carvacrol and thymol. Based on the structure-toxicity relationship between thymol analogs and insecticidal toxicities against P. shantungensis nymphs similar to the LC50 values against P. shantungensis adults, the LC50 values of thymol, carvacrol, citral, 2-isopropylphenol, 3-isopropylphenol, and 4-isopropylphenol were 28.52, 56.74 and 89.12, 71.41, 82.49, and 111.28 mg/L, respectively. These results indicate that the insecticidal mode of action of thymol analogs may be largely attributed to the methyl functional group. Thymol analogues have promising potential as first-choice insecticides against P. shantungensis adults and nymphs. PMID:28106093

  9. Predicting viral protein subcellular localization with Chou's pseudo amino acid composition and imbalance-weighted multi-label K-nearest neighbor algorithm.

    Science.gov (United States)

    Cao, Jun-Zhe; Liu, Wen-Qi; Gu, Hong

    2012-11-01

    Machine learning is a kind of reliable technology for automated subcellular localization of viral proteins within a host cell or virus-infected cell. One challenge is that the viral protein samples are not only with multiple location sites, but also class-imbalanced. The imbalanced dataset often decreases the prediction performance. In order to accomplish this challenge, this paper proposes a novel approach named imbalance-weighted multi-label K-nearest neighbor to predict viral protein subcellular location with multiple sites. The experimental results by jackknife test indicate that the presented algorithm achieves a better performance than the existing methods and has great potentials in protein science.

  10. Discriminating outer membrane proteins with Fuzzy K-nearest Neighbor algorithms based on the general form of Chou's PseAAC.

    Science.gov (United States)

    Hayat, Maqsood; Khan, Asifullah

    2012-04-01

    Outer membrane proteins (OMPs) play important roles in cell biology. In addition, OMPs are targeted by multiple drugs. The identification of OMPs from genomic sequences and successful prediction of their secondary and tertiary structures is a challenging task due to short membrane-spanning regions with high variation in properties. Therefore, an effective and accurate silico method for discrimination of OMPs from their primary sequences is needed. In this paper, we have analyzed the performance of various machine learning mechanisms for discriminating OMPs such as: Genetic Programming, K-nearest Neighbor, and Fuzzy K-nearest Neighbor (Fuzzy K-NN) in conjunction with discrete methods such as: Amino acid composition, Amphiphilic Pseudo amino acid composition, Split amino acid composition (SAAC), and hybrid versions of these methods. The performance of the classifiers is evaluated by two datasets using 5-fold crossvalidation. After the simulation, we have observed that Fuzzy K-NN using SAAC based-features makes it quite effective in discriminating OMPs. Fuzzy K-NN achieves the highest success rates of 99.00% accuracy for discriminating OMPs from non-OMPs and 98.77% and 98.28% accuracies from α-helix membrane and globular proteins, respectively on dataset1. While on dataset2, Fuzzy K-NN achieves 99.55%, 99.90%, and 99.81% accuracies for discriminating OMPs from non- OMPs, α-helix membrane, and globular proteins, respectively. It is observed that the classification performance of our proposed method is satisfactory and is better than the existing methods. Thus, it might be an effective tool for high throughput innovation of OMPs.

  11. Developmental toxicity assessment of medicinal mushroom Antrodia cinnamomea T.T. Chang et W.N. Chou (higher Basidiomycetes) submerged culture mycelium in rats.

    Science.gov (United States)

    Chen, Tai-I; Chen, Chiao-Wen; Lin, Ting-Wei; Wang, Di-Sheng; Chen, Chin-Chu

    2011-01-01

    Antrodia cinnamomea is a Taiwanese medicinal mushroom with high antioxidant and polysaccharide content. The objective of this study is to investigate developmental toxicity of A. cinnamomea in pregnant Sprague-Dawley rats. Animals were daily gavaged with A. cinnamomea mycelium at dosage levels of 0 (reverse osmosis water), 50, 150, and 500 mg/kg from gestation day (GD) 6 to 15. All dams were sacrificed on GD 20 and were subjected to cesarean section. Fetuses were examined for external, visceral, and skeletal abnormalities. All copulated females survived until the end of the study. No significant differences were recorded in body weight change, food consumption, and maternal gestational parameters. Only two fetal malformations were noted in 970 fetuses from the treatment groups. Some variations, such as enlarged fontanel, split sternebrae, absent sacral, absent caudal vertebral centra, absent thoracic centra, absent 13th-14th ribs, and fused ribs, were found during the skeletal examination, but no treatment-induced abnormalities occurred. No dose dependency was observed in any of the developmental variations. Overall observation of foetal malformations from rats given A. cinnamomea mycelium during pregnancy demonstrates that this material is not teratogenic at doses up to 500 mg/kg. It is concluded that A. cinnamomea BCRC 35398 mycelium has no teratogenic effects in female rats and is safe to be used as a functional food ingredient.

  12. Predict Gram-Positive and Gram-Negative Subcellular Localization via Incorporating Evolutionary Information and Physicochemical Features Into Chou's General PseAAC.

    Science.gov (United States)

    Sharma, Ronesh; Dehzangi, Abdollah; Lyons, James; Paliwal, Kuldip; Tsunoda, Tatsuhiko; Sharma, Alok

    2015-12-01

    In this study, we used structural and evolutionary based features to represent the sequences of gram-positive and gram-negative subcellular localizations. To do this, we proposed a normalization method to construct a normalize Position Specific Scoring Matrix (PSSM) using the information from original PSSM. To investigate the effectiveness of the proposed method we compute feature vectors from normalize PSSM and by applying support vector machine (SVM) and naïve Bayes classifier, respectively, we compared achieved results with the previously reported results. We also computed features from original PSSM and normalized PSSM and compared their results. The archived results show enhancement in gram-positive and gram-negative subcellular localizations. Evaluating localization for each feature, our results indicate that employing SVM and concatenating features (amino acid composition feature, Dubchak feature (physicochemical-based features), normalized PSSM based auto-covariance feature and normalized PSSM based bigram feature) have higher accuracy while employing naïve Bayes classifier with normalized PSSM based auto-covariance feature proves to have high sensitivity for both benchmarks. Our reported results in terms of overall locative accuracy is 84.8% and overall absolute accuracy is 85.16% for gram-positive dataset; and, for gram-negative dataset, overall locative accuracy is 85.4% and overall absolute accuracy is 86.3%.

  13. Proteomic analysis of differently cultured endemic medicinal mushroom Antrodia cinnamomea T.T. Chang et W.N. Chou from Taiwan.

    Science.gov (United States)

    Lin, Yan-Liang; Wen, Tuan-Nan; Chang, Shang-Tzen; Chu, Fang-Hua

    2011-01-01

    Antrodia cinnamomea is peculiar to Taiwan. It only grows on one host and is highly valued as an important component of several traditional Chinese medicines. In this study, the different protein expression profiles of artificially cultivated vegetative mycelium and wild-type basidiomatal fruiting bodies were compared and unique protein spots from wild-type basidiomatal fruiting body were investigated using 2D polyacrylamide gel electrophoresis and LC-MS/MS protein identification. Most of the wild-type proteins not seen in the artificially cultivated mycelium were associated to function in metabolism, cell stress, ROS scavenging, and cell growth. Several proteins from wild-type basidiomes, such as catalase, aryl-alcohol dehydrogenase, S-adenosyl-L-homocysteine hydrolase, intradiol dioxygenase, haloacid dyhydrogenase, alpha- and beta-form tubulin, prohibitin, septin, chaperone, and HSP90 ATPase, showed higher expression than those from artificially cultured mycelium at the mRNA level.

  14. Hobbes, les pirates et les corsaires. Le « Léviathan échoué » selon Carl Schmitt

    OpenAIRE

    Dominique Weber

    2005-01-01

    Parmi les nombreux problèmes que pose l’ouvrage de Carl Schmitt Le Léviathan dans la doctrine de l’État de Thomas Hobbes, il en est un, majeur, qui concerne l’utilisation de la « mythologie politique » pour expliquer la réalité ou les doctrines politiques. Il y a là, à n’en pas douter, l’expression de l’un des versants de l’irrationalisme de Schmitt. La thèse de l’auteur est très claire : parce que Hobbes ne possédait aucun « sens mythologique », il s’est trompé de monstre biblique, appelant ...

  15. Hobbes, les pirates et les corsaires. Le « Léviathan échoué » selon Carl Schmitt

    Directory of Open Access Journals (Sweden)

    Dominique Weber

    2005-04-01

    Full Text Available Parmi les nombreux problèmes que pose l’ouvrage de Carl Schmitt Le Léviathan dans la doctrine de l’État de Thomas Hobbes, il en est un, majeur, qui concerne l’utilisation de la « mythologie politique » pour expliquer la réalité ou les doctrines politiques. Il y a là, à n’en pas douter, l’expression de l’un des versants de l’irrationalisme de Schmitt. La thèse de l’auteur est très claire : parce que Hobbes ne possédait aucun « sens mythologique », il s’est trompé de monstre biblique, appelant Leviathan son traité consacré au pouvoir d’État, alors qu’il aurait dû l’appeler plus adéquatement Behemoth, manquant du coup la Meeresbild caractérisant l’Angleterre de son temps. La thèse peut paraître séduisante, elle s’appuie néanmoins sur un présupposé fort contestable, car Hobbes ne vise nullement à créer des mythes. Il s’agit donc d’interroger la théorisation hobbesienne de la piraterie, d’une part, et de la dissidence religieuse « sauvage », d’autre part, afin de montrer que le choix par Hobbes des monstres du Livre de Job est un choix rationnellement assumé.

  16. Accurate prediction of protein structural classes by incorporating predicted secondary structure information into the general form of Chou's pseudo amino acid composition.

    Science.gov (United States)

    Kong, Liang; Zhang, Lichao; Lv, Jinfeng

    2014-03-07

    Extracting good representation from protein sequence is fundamental for protein structural classes prediction tasks. In this paper, we propose a novel and powerful method to predict protein structural classes based on the predicted secondary structure information. At the feature extraction stage, a 13-dimensional feature vector is extracted to characterize general contents and spatial arrangements of the secondary structural elements of a given protein sequence. Specially, four segment-level features are designed to elevate discriminative ability for proteins from the α/β and α+β classes. After the features are extracted, a multi-class non-linear support vector machine classifier is used to implement protein structural classes prediction. We report extensive experiments comparing the proposed method to the state-of-the-art in protein structural classes prediction on three widely used low-similarity benchmark datasets: FC699, 1189 and 640. Our method achieves competitive performance on prediction accuracies, especially for the overall prediction accuracies which have exceeded the best reported results on all of the three datasets.

  17. Predict protein structural class for low-similarity sequences by evolutionary difference information into the general form of Chou's pseudo amino acid composition.

    Science.gov (United States)

    Zhang, Lichao; Zhao, Xiqiang; Kong, Liang

    2014-08-21

    Knowledge of protein structural class plays an important role in characterizing the overall folding type of a given protein. At present, it is still a challenge to extract sequence information solely using protein sequence for protein structural class prediction with low similarity sequence in the current computational biology. In this study, a novel sequence representation method is proposed based on position specific scoring matrix for protein structural class prediction. By defined evolutionary difference formula, varying length proteins are expressed as uniform dimensional vectors, which can represent evolutionary difference information between the adjacent residues of a given protein. To perform and evaluate the proposed method, support vector machine and jackknife tests are employed on three widely used datasets, 25PDB, 1189 and 640 datasets with sequence similarity lower than 25%, 40% and 25%, respectively. Comparison of our results with the previous methods shows that our method may provide a promising method to predict protein structural class especially for low-similarity sequences.

  18. Play the Role from Moliere's Chou(Clown) of Servant s Comics as in Pekin Opera%以京剧丑角演绎莫里哀喜剧中的仆人形象

    Institute of Scientific and Technical Information of China (English)

    曹凌燕

    2012-01-01

    丑角俗称“小花脸”,在传统京剧舞台上占有重要地位,有所谓“无丑不成戏”之说。今天,在以丑角为主的戏难得一见,甚至戏中丑角出场也越来越少的境况下,一出由福建京剧院演出的丑角戏《司卡班的诡计》亮相于8月30日的上海舞台,并以中法艺术家联合排演的形式引起关注。

  19. Multi-iPPseEvo: A Multi-label Classifier for Identifying Human Phosphorylated Proteins by Incorporating Evolutionary Information into Chou's General PseAAC via Grey System Theory.

    Science.gov (United States)

    Qiu, Wang-Ren; Zheng, Quan-Shu; Sun, Bi-Qian; Xiao, Xuan

    2017-03-01

    Predicting phosphorylation protein is a challenging problem, particularly when query proteins have multi-label features meaning that they may be phosphorylated at two or more different type amino acids. In fact, human protein usually be phosphorylated at serine, threonine and tyrosine. By introducing the "multi-label learning" approach, a novel predictor has been developed that can be used to deal with the systems containing both single- and multi-label phosphorylation protein. Here we proposed a predictor called Multi-iPPseEvo by (1) incorporating the protein sequence evolutionary information into the general pseudo amino acid composition (PseAAC) via the grey system theory, (2) balancing out the skewed training datasets by the asymmetric bootstrap approach, and (3) constructing an ensemble predictor by fusing an array of individual random forest classifiers thru a voting system. Rigorous cross-validations via a set of multi-label metrics indicate that the multi-label phosphorylation predictor is very promising and encouraging. The current approach represents a new strategy to deal with the multi-label biological problems, and the software is freely available for academic use at http://www.jci-bioinfo.cn/Multi-iPPseEvo.

  20. Evaluation de la contamination chimique et changement du régime alimentaire des marsouins communs (Phocoena phocoena) échoués au sud de la mer du Nord

    OpenAIRE

    Mahfouz, Celine

    2014-01-01

    The North Sea is heavily impacted by human activities such as overfishing and pollution. Due to their position as top predators in the ocean, marine mammals are becoming increasingly affected by anthropogenic activities. The large-scale surveys SCANS in 1994 and SCANS II in 2005 that were held in the North Sea to estimate the abundance of small cetaceans highlighted a major shift in the distribution of harbour porpoises (Phocoena phocoena) from the northern parts of the North Sea to its easte...

  1. A specimen of Paralycoptera Chang & Chou 1977 (Teleostei: Osteoglossoidei) from Hong Kong (China) with a potential Late Jurassic age that extends the temporal and geographical range of the genus.

    Science.gov (United States)

    Tse, Tze-Kei; Pittman, Michael; Chang, Mee-Mann

    2015-01-01

    We describe a Mesozoic fish Paralycoptera sp. (Teleostei: Osteoglossoidei), on the basis of a postcranial skeleton collected from the volcaniclastic mudstones of the Lai Chi Chong Formation of Hong Kong, China. The new finding-representing the city's first Mesozoic fish-extends the geographical distribution of Paralycoptera from eastern mainland China into Hong Kong, demonstrating a wider distribution than previously appreciated for this genus. A radiometric age for the Lai Chi Chong Formation of 146.6 ± 0.2 Ma implies a temporal range expansion for Paralycoptera of approximately 40 million years back from the Early Cretaceous (∼110 Ma). However, spores found in the Formation suggest an Early Cretaceous age that is consistent with the existing age assignment to Paralycoptera. We argue that the proposed temporal range extension is genuine because it is based on recent high precision radiometric age data, but given the discrepancies with the biostratigraphic ages further investigation is needed to confirm this. This study provides an important step towards revealing Hong Kong's Mesozoic vertebrate fauna and understanding its relationship to well-studied mainland Chinese ones.

  2. New results on the laser produced positrons using the TITAN and OMEGA EP lasers

    Science.gov (United States)

    Chen, Hui; Wilks, S.; Meyerhofer, D. D.; Beiersdorfer, P.; Dollar, F.; Falk, K.; Hazi, A.; Link, A.; Murphy, C. D.; Park, J.; Seely, J.; Szabo, C. I.; Shepherd, R.; Tommasini, R.; Welch, D.; Zulick, K.

    2010-11-01

    We performed new experiments and simulations on generating positrons with intense lasers [1]. A cone shaped positron jet is produced by irradiating a gold target with an intense picosecond duration laser pulse. The jet has ˜20 degree angular divergence and a quasi-monochromatic energy distribution with energy 4 to 20 MeV. The conversion efficiency from laser energy to positrons in the jet is ˜ 2x10-4. The positron angular and energy distributions are controlled by the laser and target conditions. The positron acceleration mechanism is identified experimentally as the sheath electric field on the rear surface of target. This talk will present the details of these new experimental and simulation results.[4pt] [1] Hui Chen, S. C. Wilks, D. D. Meyerhofer et al., PRL 105,015003 (2010)

  3. Type 1 insulin-like growth factor receptor monoclonal antibody (HX-1162 treatment for liver cancer

    Directory of Open Access Journals (Sweden)

    Chen XH

    2013-05-01

    Full Text Available Xue-Hui Chen, Zhi-Qiang Li, Hua Peng, Su-Mei Jin, Hui-Qing Fu, Tie-Chui Zhu, Xiao-Gang WengThe First Affiliated Hospital of Xinxiang Medical University, Weihui, People's Republic of ChinaAbstract: One of the most important molecules mediating the proliferation, growth, and metastasis of cancer cells is insulin-like growth factor (IGF, with its receptor IGF-R1. Here, we describe the potential of an IGF-1R monoclonal antibody, HX-1162, on liver cancer apoptosis in vitro and in vivo. We found that HX-1162 could induce the apoptosis of cultured liver cancer cells. Additionally, HX-1162 treatment inhibited the tumor growth after cancer cell grafting and enhanced the cell apoptosis inside the tumor tissue. We conclude that IGF-R1 targeting therapy provides a new avenue toward treating liver cancer.Keywords: IGF, IGF-R1, apoptosis, hepatocellular carcinoma

  4. Nuevos Miembros, Palabras del Académico José Félix Patiño Restrepo.

    Directory of Open Access Journals (Sweden)

    Jose Felix Patiño Restrepo

    2004-03-01

    Son numerosas las contribuciones de Quintero a la cirugía biliar. Una de especial significación es el manejo quirúrgico de las estenosis biliares benignas con la técnica de hepático-yeyunostomía en Y de Roux con asa subcutánea, descrita por Hao-Hui Chen. Con laboriosidad y gran honestidad intelectual, Quintero rescató para este autor del Colegio Médico de Pekín el debido crédito. Su serie de 75 casos operados con excelente resultado es una de las mayores en América Latina y tal vez en el mundo...

  5. Wave-Sediment Interaction in Muddy Environments: A Field Experiment

    Science.gov (United States)

    2009-01-01

    Liu, 1987), generalized Voigt solids (Jiang and Mehta, 1995; Jiang and Mehta, 1996), and non-Newtonian fluids (Chou et al., 1993; Foda et al., 1993...dissipation is significantly stronger (Gade, 1957; Chou et al., 1993; Foda et al., 1993). On the other hand, even under mildly energetic waves mud...state can change from consolidated to fluid over the duration of one storm (Chou et al., 1993; Foda et al., 1993; also deWitt, 1995). The similar

  6. C:\\Users\\AISA\\Desktop\\SORO S..xps

    African Journals Online (AJOL)

    AISA

    production de chou car pouvant réduire le nombre de pucerons et les larves de plusieurs autres insectes ... des résultats. Mots clés : Chou, Ergofito Defense, engrais organique, insecticide. ABSTRACT ..... Utilisation de biopesticides contre les ...

  7. Spectroscopy of positron annihilation gamma rays from laser-exited media

    Science.gov (United States)

    Szabo, C. I.; Feldman, U.; Seely, J.; Hudson, L.; Chen, Hui; Tommasini, R.; Hazi, A.; Shepherd, R.; Zulick, C.; Dollar, F.; Falk, K.; Murphy, C. D.

    2010-11-01

    Motivated by calculations for gamma ray yields and results of positron beam measurements from laser irradiated high Z targets [1], a Gamma-ray Crystal Spectrometer (GCS) was built by Artep Inc. and fielded at the Titan laser facility of LLNL. The spectrometer is equipped with heavy shielding around a cylindrically bent Ge crystal in a transmission geometry. The Bremsstrahlung continuum and the 511 keV annihilation gamma rays are dispersed by the Ge(440) crystal and detected by an image plate placed on the Rowland circle. The gamma rays originate inside the thick target material (1 to 3 mm Au disks) where positrons are produced in the intense field of the high energy (350 J) short pulse (10 ps) laser irradiation. In addition to the spectrometer, two different electronic detection systems also recorded the gamma ray spectra using the single hit per pixel technique. The first gamma ray spectra recorded with the crystal spectrometer and the electronic detectors will be reported. [4pt] [1] Hui Chen et al., PRL 105, 015003 (2010)

  8. Nanofluidic Pre-Concentration Devices for Enhancing the Detection Sensitivity and Selectivity of Biomarkers for Human Performance Monitoring

    Science.gov (United States)

    2012-12-01

    Polanco , V. Chaurey, C.F. Chou*, N.S. Swami*, “Nano-constriction device for rapid protein pre-concentration through balance of electrokinetic forces...23, 2569. (c) Basuray, S.; Chang, H.-C. Phys. Rev. E 2007, 75, 060501. (17) Chaurey, V.; Polanco , C.; Chou, C. F.; Swami, N. S. Biomicrofluidics...Chaurey, V., Lab Chip 2009, 9, 3212–3220. [13] Chaurey, V., Polanco , C. F., Chou, C.-F., Swami, N. S. Biomicrofluidics 2012, 6, 012806. [14] Swami, N

  9. Scrotal aggressive angiomyxoma mimicking inguinal hernia%类似腹股沟疝的阴囊入侵性血管粘液瘤

    Institute of Scientific and Technical Information of China (English)

    C. C. Wu; S.S.D.Yang; D.T.H. Chin; C.H. Hsieh; Y.M.Hsueh; Y. C.Tsai

    2007-01-01

    @@ Dear Sir, I am Dr Yao-Chou Tsai, from Department of Urology,Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei,Taiwan, China. I write to you to present a case report of scrotal aggressive angiomyxoma (AAM).

  10. An Atomic Clock with 10 (exp -18) Instability

    Science.gov (United States)

    2013-09-13

    Parker, Metrologia 47, 1 10 (2010). 6. T. Rosenband et al., Science 319, 1808 1812 (2008). 7. C. W. Chou, D. B. Hume , J. C. J. Koelemeij, D. J. Wineland...W. Chou, D. B. Hume , T. Rosenband, D. J. Wineland, Science 329, 1630 1633 (2010). 27. D. Kleppner, Phys. Today 59, 10 (2006). 28. S. Schiller et al...for financial support; D. Hume for experimental assistance; and T. Fortier and S. Diddams for femtosecond optical frequency comb measurements

  11. Initiation and Modification of Reaction by Energy Addition: Kinetic and Transport Phenomena

    Science.gov (United States)

    1993-10-01

    MODIFICATION OF REACTION BY ENERGY ADDITION: KINETIC AND TRANSPORT PHENOMENA by Francis E. Fendell and Mau-Song Chou Center for Propulsion Technology...TA - A2 L AUHOWAC - F49620-90-C-0070 Francis E. Fendell and Mau-Song Chou 7. PEMOS101IG ORGANIZATION NAME(S AND...a gaseous mixture is more pertinent for the supersonic-combustor applications of interest to the Air Force (compare Figs. 1 and 2) (Carrier, Fendell

  12. Modifications of Morphometrical and Physiological Parameters of Pepper Plants Grown on Artificial Nutrient Medium for Experiments in Spaceflight

    Science.gov (United States)

    Nechitailo, Galina S.

    2016-07-01

    MODIFICATIONS OF MORPHOMETRICAL AND PHYSIOLOGICAL PARAMETERS OF PEPPER PLANTS GROWN ON ARTIFICIAL NUTRIENT MEDIUM FOR EXPERIMENTS IN SPACEFLIGHT Lui Min*, Zhao Hui*, Chen Yu*, Lu Jinying*, Li Huasheng*, Sun Qiao*, Nechitajlo G.S.**, Glushchenko N.N.*** *Shenzhou Space Biotechnology Group, China Academy of Space Technology (CAST), **Emanuel Institute of Biochemical Physics of Russian Academy of Sciences (IBCP RAS) mail: spacemal@mail.ru ***V.L. Talrose Institute for Energy Problems of Chemical Physics of Russian Academy of Science (INEPCP RAS) mail: nnglu@ mail.ru In circumstances of space flights, long residence of the staff at space stations and space settlements an optimal engineering system of the life-support allowing to solve a number of technical and psychological problems for successful work and a life of cosmonauts, researchers, etc. is important and prime. In this respect it is necessary to consider growing plants on board of spacecraft as one of the units in a life-support system. It is feasible due to modern development of biotechnologies in growing plants allowing us to receive materials with new improved properties. Thus, a composition and ratio of components of nutrient medium can considerably influence on plants properties. We have developed the nutrient medium in which essential metals such as iron, zinc, copper were added in an electroneutral state in the form of nanoparticles instead of sulfates or other salts of the same metals. Such replacement is appropriate through unique nanoparticles properties: metal nanoparticles are less toxic than their corresponding ionic forms; nanoparticles produce a prolonged effect, serving as a depot for elements in an organism; nanoparticles introduced in biotic doses stimulate the metabolic processes of the organism; nanoparticles effect is multifunctional. Pepper strain LJ-king was used for growing on a nutrient medium with ferrous, zinc, copper nanoparticles in different concentrations. Pepper plants grown on

  13. Wave-Sediment Interaction in Muddy Environments: Subbottom Field Experiment

    Science.gov (United States)

    2012-09-30

    Berkeley, Doctoral thesis, 149p. Chou, H.-T., M.A. Foda , and J.R. Hunt (1993). Rheological response of cohesive sediments to oscillatory forcing”, In...dissipation by muddy seafloors, Geophys. Res. Lett. 35/7, L07611. Foda , A.M., J.R. Hunt, and H.-T. Chou (1993). A nonlinear model for the...fluidization of marine mud by waves, J. Geophys. Res. 98, 7039-7047. Foda M.A. and S.Y., Tzang (1994). Resonant fluidization of silty soil by water waves

  14. Effect of rehabilitation on a patient suffering from a tuberculous brain abscess with Gerstmann's syndrome: case report

    OpenAIRE

    Kuo CL; Lo SF; Liu CL; Chou CH; Chou LW

    2012-01-01

    Chih-Lan Kuo1, Sui-Foon Lo1,2, Chun-Lin Liu3, Chia-Hui Chou4, Li-Wei Chou1,2,5¹Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; ²School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 3Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan; 4Department of Infectious disease, China Medical University Hospital, Taichung, Taiwan; 5Department of Physical...

  15. Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells

    Directory of Open Access Journals (Sweden)

    Chen YH

    2013-07-01

    Full Text Available Ying-Hui Chen,1,2,* Jo-Yu Wang,3,* Bo-Syong Pan,3,4 Yi-Fen Mu,3 Meng-Shao Lai,3,4 Edmund Cheung So,5 Thian-Sze Wong,6 Bu-Miin Huang3,4 1Department of Anesthesia, Chi-Mei Medical Center, Liouying, 2Department of Nursing, Min-Hwei College of Health Care Management, 3Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, 4The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 5Department of Anesthesia, An Nan Hospital, China Medical University, Tainan, Taiwan; 6Department of Surgery, University of Hong Kong Medical Center, Faculty of Medicine, The University of Hong Kong, Hong Kong *Authors contributed equally to this work Purpose: The present study aims to investigate whether the combination treatment of cordycepin (an extracted pure compound from Cordyceps sinensis and cisplatin (a platinum-based chemotherapy drug has better apoptotic effect in head and neck squamous cell carcinoma (HNSCC. Methods: The apoptotic influences of cordycepin and/or cisplatin treatments to human OC3, OEC-M1, and FaDu HNSCC cells were investigated by morphological observations, viability assay, flow cytometry assay, and Western blotting methods. Results: Data showed that the cell death phenomenon increased as the dosage of cordycepin or cisplatin increased, and it appeared more in cordycepin plus cisplatin cotreatment among three cell lines. Cell survival rates significantly decreased as the dosage of cordycepin or cisplatin increased, and the better apoptotic effects were observed in cotreatment. Cell cycle analysis further demonstrated that percentages of subG1 cells in cordycepin or cisplatin treatments significantly increased, suggesting that cells underwent apoptosis, and cordycepin plus cisplatin induced many more subG1 cells. Furthermore, cordycepin or cisplatin induced caspase-8, caspase-9, caspase-3, and poly adenosine diphosphate-ribose polymerase protein cleavages, and stimulated c

  16. Use of vectors in sequence analysis.

    Science.gov (United States)

    Ishikawa, T; Yamamoto, K; Yoshikura, H

    1987-10-01

    Applications of the vector diagram, a new type of representation of protein structure, in homology search of various proteins including oncogene products are presented. The method takes account of various kinds of information concerning the properties of amino acids, such as Chou and Fasman's probability data. The method can detect conformational similarities of proteins which may not be detected by the conventional programs.

  17. Recommended Values of the Thermophysical Properties of Eight Alloys, Major Constituents and Their Oxides

    Science.gov (United States)

    1966-01-01

    911 132. 7239 133. 27635 134. 37902 135. 136. 137. 7689 27207 7602 417 NIOBIUM Brown, A., Zemansky , M.W. and Boorse, H.A., Phys. Rev...86 (1), 134-5, 1952. Brown, A., Zemansky , M.W. and Boorse, H.A., Phys. Rev., 92, 52-8, 1953. Chou, C. , White, D. and Johnston, H. L. , Phys

  18. Using a Radical-Derived Character E-Learning Platform to Increase Learner Knowledge of Chinese Characters

    Science.gov (United States)

    Chen, Hsueh-Chih; Hsu, Chih-Chun; Chang, Li-Yun; Lin, Yu-Chi; Chang, Kuo-En; Sung, Yao-Ting

    2013-01-01

    The present study is aimed at investigating the effect of a radical-derived Chinese character teaching strategy on enhancing Chinese as a Foreign Language (CFL) learners' Chinese orthographic awareness. An e-learning teaching platform, based on statistical data from the Chinese Orthography Database Explorer (Chen, Chang, Chou, Sung, & Chang,…

  19. A de Gaulle-Like Trip

    Science.gov (United States)

    Yang, Chen Ning

    2013-05-01

    Last night, President Nixon arrived in the People's Republic of China to talk with Chairman Mao Tse-tung and Premier Chou En-lai. What is likely to be achieved in these talks? There has been a lot of speculation on this subject for the last few months, but little consensus of opinion...

  20. Évaluation des niveaux de contamination en éléments traces ...

    African Journals Online (AJOL)

    SARAH

    30 juil. 2013 ... Évaluation de contamination en traces métalliques de Laitue et Chou dans la ... to limit or reduce the contamination of plants grown in the Gounti Yena valley. ..... polycyclic aromatic hydrocarbons on ryegrass exposed to ...

  1. The Development of an Automated Armor Data Base - Phase 1

    Science.gov (United States)

    1993-09-01

    success of this program task. ARL/XD Michael Castro Shun-Chin Chou Dennis Gosselin Robert Muldoon Joseph Prifti Karl Salomon Anthone Zarkades CSTA William ...ATTN: DTIC-FDAC 1 MIA/ CINDAS , Purdue University, 2595 Yeager Road, West Lafayette, IN 47905 Commander, Army Research Office, P.O. Box ’ 2211, Research

  2. Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics

    Science.gov (United States)

    2016-09-01

    mutant human non-small cell lung carcinoma cells. Cell Death Dis. 4, e814. Chou, T.-C. (2010). Drug combination studies and their synergy... gastric cancer cells. Mol. Cancer Ther. 8, 2526–2536.Cell Reports 14, 1–11, February 16, 2016 ª2016 The Authors 11

  3. Effets de doses croissantes des composts de fumiers de poules sur ...

    African Journals Online (AJOL)

    SARAH

    31 mai 2014 ... Mots Clés : Compost de fumiers de poules, engrais minéraux, Chou de Chine, sol acide, efficience .... raison d'une plantule par pot à la date du 29 mars. 2013. Le NPK ..... Jama B, Palm CA, Buresh RJ, Niang AI, Gachengo C,.

  4. Integrated DoD Voice and Data Networks and Ground Packet Radio Technology

    Science.gov (United States)

    1976-08-01

    also been well-studied. Several algorithms are found in the litera- ture [CHOU, 1973], ( ESAU , 1966], [WOO, 1973]. Typically, the algorithms solve...Data Communications Symposium, St. Peters- burg, Florida, November 13-15, 1973. ( ESAU , 1966] Esau , L.R. and K.C. Williams, "On Teleproces- sing

  5. Proton-proton elastic scattering at ultrahigh energies

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Shaukat, M.A.; Fazal-e-Aleem (University of the Punjab, Lahore (Pakistan). Dept. of Physics)

    1981-05-30

    The authors use a geometrical model of high-energy pp elastic scattering as proposed by Chou and Yong to analyse experimental data available at present and consider the predictions of the dipole pomeron model for pp elastic scattering at ultrahigh energies. Theoretical results for differential cross sections are compared with experimental data.

  6. Anisotropy function for pion-proton elastic scattering

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, Mohammad; Fazal-e-Aleem; Rashid, Haris

    1988-09-01

    By using the generalised Chou-Yang model and the experimental data on ..pi../sup -/p elastic scattering at 200 GeV/c, the anisotropy function which reflects the non-isotropic nature of elastic scattering is computed for the reaction ..pi../sup -/p -> ..pi../sup -/p.

  7. Meson-proton elastic scattering At 250 GeV/c

    Science.gov (United States)

    Saleem, Mohammad; Rashid, Haris; Aleem, Fazal-e.

    1988-01-01

    Very recent measurements of pi-+p and K+p elastic scattering at 250GeV/c have been explained by using the generalised Chou-Yang model. Dips are predicted to occur at -t=3.63 and 4.36(GeV/c)2 respectively.

  8. Anisotropy function for proton-proton elastic scattering

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, Mohammad; Fazal-e-Aleem; Azhar, I.A. (Punjab Univ., Lahore (Pakistan). Centre for High Energy Physics)

    1990-07-01

    By using the generalized Chou-Yang model and the experimental data on pp elastic scattering at 53 GeV, the anisotropy function which reflects the non-isotropic nature of elastic scattering is computed for the reaction pp{yields}pp. (author).

  9. Antiproton-proton elastic scattering at 1. 8 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem; Saleem, M. (Punjab Univ., Lahore (Pakistan). Centre for High Energy Physics); Yodh, G.B. (California Univ., Irvine, CA (USA). Dept. of Physics)

    1990-11-01

    The predictions, based on the generalized Chou-Yang model, are made for the most recent measurements of antiproton-proton elastic scattering at {radical}s = 1.8 TeV. These results have been compared with the recent theoretical predictions of various models. (author).

  10. Resolution of Low Back and Radicular Pain in a 40-year-old Male United States Navy Petty Officer after Collaborative Medical and Chiropractic Care

    Science.gov (United States)

    2009-12-08

    the low back, radiating into the right “hip” ( sacroiliac joint ), buttock, and leg and numbness in the lateral right foot. An examination was performed...2006;12(7):659-68. 12. Chou R, Qaseem A, Snow V, Casey D, Cross JH, Shekelle P, et al. Diagnosis and treatment of low back pain: a joint clinical

  11. Acoustic Analyses of the Singing Vibrato in Traditional Peking Opera.

    Science.gov (United States)

    Han, Qichao; Zhang, Ruifeng

    2017-01-16

    China's traditional Peking Opera has four standard categories of roles: Sheng, Dan, Jing, and Chou, the singing vibrato of each displaying a different auditory effect. The audio and respiratory signals were recorded for two performers of the Qing Yi role, one of the Jing role, one of the Chou role, one of the Lao Sheng role, one of the Xiao Sheng role, and one of the Lao Dan role. The recordings gained eventually consisted of 24 representative songs from six roles. The rates and extents of vibrato, fundamental frequency, and rib cage signals were analyzed. Two findings were obtained: (1) the classical opera singing vibratos of China and Western countries are acoustically different from each other; and (2) in Peking Opera, the singing vibratos of different roles show significant acoustic differences.

  12. Changes in Terrestrial Water Availability under Global Warming

    Science.gov (United States)

    Lan, C. W.; Lo, M. H.; Chou, C.

    2014-12-01

    Under global warming, the annual range of precipitation is widening (Chou and Lan, 2012; Chou et al., 2013) and the frequency of precipitation extreme events also increases. Due to nonlinear responses of land hydrological process to precipitation extremes, runoff can increase exponentially, and on the hard hand, soil water storage may decline. In addition, IPCC AR5 indicates that soil moisture decreases in most areas under the global warming scenario. In this study, we use NCAR Community Land Model version 4 (CLM4) to simulate changes in terrestrial available water (TAW, defined as the precipitation minus evaporation minus runoff, and then divided by the precipitation) under global warming. Preliminary results show that the TAW has clear seasonal variations. Compared to previous studies, which do not include the runoff in the calculations of the available water, our estimates on the TAW has much less available water in high latitudes through out the year, especially under extreme precipitation events.

  13. Electrokinetic Enrichment and Detection of Neuropeptide for Performance Monitor

    Science.gov (United States)

    2016-06-14

    pre- concentration in physiological media by electrokinetic force balance”, K.T. Liao, M. Tsegaye, V. Chaurey, C.F. Chou, N. Swami*. Electrophoresis... concentration within physiological media over that achieved through negative dielectrophoresis at nanoscale constriction gap devices, by utilizing an... concentration in physiological media by electrokinetic force balance”, Electrophoresis (2012), 33, 1958-1966. DOI: 10.1002/elps.201100707 (ii) V. Chaurey, A

  14. Geometrical Models and Hadronic Radii

    CERN Document Server

    Zahra, Sarwat; Fazal-e-Aleem,; Hussain, Talib; Zafar, Abrar Ahmad; Tahir, Sohail Afzal

    2015-01-01

    By using electromagnetic form factors predicted by Generalized Chou Yang model (GCYM), we compute rms radii of several hadrons with varying strangeness content such as (Pion, Proton, Phi, Lambda0, Sigma+, Sigma- and Omega-). The computed radii are found quite consistent with the results of other models and experiments, indicating excellent predicting power of GCYM. The results indicate that rms radii decrease with increase in strangeness content, separately for mesons and baryons.

  15. The Decision to Intervene. A Comparison of Soviet Interventions from 1953 to 1980

    Science.gov (United States)

    1980-06-01

    in February 1956, put Party dogmatists on the defensive and increased political discussion in Poland. In , f a speech by Anastas Mikoyan, Deputy...Congress in Peking, where he had had discussions with Mao Tse-Tung and Chou En-lai, and with Anastas Mikoyan, representing the Soviet Union. It seems...July, Anastas Mikoyan, of the Soviat Council of Ministers arrived in Budapest to look into the situation that had developed. He apparently had instruc

  16. Multiple Factors-Aware Diffusion in Social Networks

    Science.gov (United States)

    2015-05-22

    imbalance problem is encountered, i.e. skewed class dis- tribution. We use SMOTE[4], which doubles the size of the minority class , and then apply...Multiple Factors-Aware Diffusion in Social Networks Chung-Kuang Chou(B) and Ming-Syan Chen Department of Electrical Engineering, National Taiwan ...University, Taipei, Taiwan ckchou@arbor.ee.ntu.edu.tw, mschen@cc.ee.ntu.edu.tw Abstract. Information diffusion is a natural phenomenon that informa- tion

  17. Multifunctional Flexible Composites Based on Continuous Carbon Nanotube Fiber

    Science.gov (United States)

    2014-07-28

    1550 1 AFOSR FINAL REPORT Principal Investigator: Tsu-Wei Chou Pierre S. du Pont Chair of Engineering Department of Mechanical Engineering...form of an electrical resistance hysteresis loop (Fig. 1b). This loop becomes more pronounced at higher load cycles and indicates that, at the same...composite (18.4 MPa) [5]. After interfacial failure, some CNT bundles were pulled out from the epoxy layer, which indicates the infiltration of the resin

  18. Cryptanalysis and improvement of quantum secure communication network protocol with entangled photons for mobile communications

    Science.gov (United States)

    Gao, Gan

    2014-12-01

    Recently, a communication protocol called controlled bidirectional quantum secret direct communication for mobile networks was proposed by Chou et al (2014 Mobile Netw. Appl. 19 121). We study the security of the proposed communication protocol and find that it is not secure. The controller, Telecom Company, may eavesdrop secret messages from mobile devices without being detected. Finally, we give a possible improvement of the communication protocol.

  19. Mathematical Imaging and Modeling of Cortical Spreading Depression and Wound Healing

    Science.gov (United States)

    2015-02-05

    phase diagram that maps out when a retinal detachment is unstable, or is stable and will likely heal . We have begun to generalize this problem in two...Spreading Depression and W mmd Healing Sb. GRANT NUMBER Sc. PROGRAM ELEMENT NUMBER 611102 6. AUTHORS Sd. PROJECT NUMBER Tom Chou Se. TASK NUMBER...Spreading Depression and Wound Healing ." The research conducted under this grant represents advances made in image analysis, front tracking, modeling

  20. Resolved Sideband Spectroscopy for the Detection of Weak Optical Transitions

    Science.gov (United States)

    2013-08-01

    Kermit Murray, Kathy O’Neal, Paige x 12 Patterson, Robert Perlis, Erwin Poliakoff, Leonard Richardson, Kresimir Rupnik, David Sherrill, and Cathy...24Mg+,” Phys. Rev. Lett. 102, 013006 (2009). [33] T. Rosenband, P. O. Schmidt, D. B. Hume , W. M. Itano, T. M. Fortier, J. E. Stalnaker, K. Kim, S. A...2007). [34] T. Rosenband, D. B. Hume , P. O. Schmidt, C. W. Chou, A. Brusch, L. Lorini, W. H. Oskay, R. E. Drullinger, T. M. Fortier, J. E. Stalnaker

  1. Territorial Developments Based on Graffiti: a Statistical Mechanics Approach

    Science.gov (United States)

    2011-10-28

    public, since it is usually a sign of the presence of criminal gangs engaged in illegal or underground activities such as drug trafficking or extortion...and T. Chou, Chiral Molecule Adsorption on Helical Polymers, Phys. Rev. E 69 021805 (2003). [25] R. G. Edwards and A. D. Sokal, Generalization of the...Fagan, The Social Organization of Drug Use and Drug Dealing among Urban Gangs, Criminol. 27 633–670 (1989). [29] C. M. Fortuin, and P. W. Kasteleyn, On

  2. STUDY ON STRESS CONCENTRATIONS IN AN INTRAPLY HYBRID COMPOSITE SHEET

    Institute of Scientific and Technical Information of China (English)

    曾庆敦; 黄小清; 林雪慧

    2001-01-01

    A reasonably, simply and accurately modified shear-lag model was proposed.Based on the model, the stress redistributions due to the failure of some fibers in an intraply hybrid composite under tension were analyzed. The results show that the present calculating stress concentration factors very coincide with Fukuda and Chou' s results, thus verifying the reasonableness and correctness of the present model and methods.

  3. Polynitro Polycyclic Cage Compounds

    Science.gov (United States)

    1992-03-01

    AGENCY -U E ONLY Leave 0!anK) 2. REPORT DTE 3. REPORT TYPE AND DATES COVERED March 92. Interim Report 11/1/89 to 4/30/91 4. TITLE AND SUBTITLE S. FUNDING...Rearrangement of Substituted 3a- and 5a-Hydroxytricyclo[5.2.1.0 2 ,6 ] decadienes ," Tetrahedron Lett., Vol. 29, p. 4031, 1988. 11. Marchand, A. P. and Chou, T

  4. Feasibility Study: Hollow Plastic Spheres to Increase Hydraulic Fluid Compressibility

    Science.gov (United States)

    1982-07-01

    MICROMECHANICS FAILURE CRITERIA FOR COMPOSITES ; AUTHOR: GREESCZUK, LONCIN, B. 5. POISSON’S RATIO FOR RIGID PLASTIC FOAMS; AUTHOR: RINDE...S.A. Thuysbaert A.Stevens N4 Schwartz SPRL Schulmon Plastics SA Polytexco PVBA Polyform SA Plastiques Manufactures Plastimetal PVBA S.A...Plastics Corp. Plastiques GM Ltd. Rochevert, Inc. Polysar Limited, Kayson Plastics Div. Canlew Chemicals, Ltd. 4th Fl., 8-1, Hong Chou S. Rd., Sec. 1

  5. Conditional Autoregregressive Range (CARR) Based Volatility Spillover Index For the Eurozone Markets

    OpenAIRE

    Bayraci, Selcuk; Demiralay, Sercan

    2013-01-01

    : We examine the volatility spillovers among major Eurozone countries employing the Diebold and Yilmaz (2012) model with time-varying conditional ranges generated from conditional autoregressive range (CARR) model of Chou (2005). The empirical findings, based on a data set covering a fifteen year period (1998-2013), suggest a total volatility spillover index in a very high degree. 74.9% of total volatility in the Eurozone markets is attributed to spillover effects from other markets. Moreover...

  6. Proton-proton elastic scattering at ultrahigh energies

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Shaukat, M.A.; Fazal-e-Aleem (University of the Punjab, Lahore (Pakistan). Dept. of Physics)

    1981-05-30

    Recent experimental results on proton-proton elastic scattering at high energies are discussed in the context of the comments by Chou and Yang. There does not appear to be any tendency that the experimental results would agree with the predictions of the geometrical model even at ultrahigh energies. The angular distribution structure as described by using the dipole pomeron is consistent with the experimental data at presently available high energies and predicts results quite different from the geometrical model.

  7. Bibliography on Hot Isostatic Pressing (HIP) Technology

    Science.gov (United States)

    1992-11-01

    analysis Centers Program Management of Dr. Forrest R. Frank currently and Mr. Paul M. Klinefelter previously. MIAC is operated by the Center for...8217ered the history of HIPing. manufacturing systems, and studies of HIPing applications in the areas of castings, powder consolidation, and rejuvenation of...Beryllium as a Function of Strain Rate and Stress History Chou, S. C., Aronin. L. R., Kignam, J. F., Rainey, J. H. The Royal Society. London, UK Proc 4th

  8. Appendiceal pus in a hernia sac simulating strangulated femoral hernia: a case report

    OpenAIRE

    Hsiao, Tien-Fa; Chou,

    2011-01-01

    Tien-Fa Hsiao, Yenn-Hwei ChouDepartment of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwanAbstract: Acute appendicitis involving the hernia sac is infrequent but well-documented in medical literature. In most instances, it occurs within the right inguinal (Amyand’s hernia) or right femoral hernia (de Garengeot hernia). The diagnosis is always mistaken for incarcerated groin hernia. During surgery, the appendix itself, either perforated or strangulated, is most commonly...

  9. Applying model simulation and photochemical indicators to evaluate ozone sensitivity in southern Taiwan

    Institute of Scientific and Technical Information of China (English)

    Yen-Ping Peng1; Kang-Shin Chen2; Hsin-Kai Wang2; Chia-Hsiang Lai3; Ming-Hsun Lin4; Cheng-Haw Lee4

    2011-01-01

    Ozone sensitivity was investigated using CAMx simulations and photochemical indicator ratios at three sites (Pingtung City, ChaoChou Town, and Kenting Town) in Pingtung County in southern Taiwan during 2003 and 2004.The CAMx simulations compared fairly well with the hourly concentrations of ozone.Simulation results also showed that Pingtung City was mainly a volatile organic compounds (VOC)-sensitive regime, while Chao-Chou Town was either a VOC-sensitive or a NOx-sensitive regime, depending on the seasons.Measurements of three photochemical indicators (H202, HNO3, and NOy) were conducted, and simulated three transition ranges of H202/HNO3 (0.5-0.8), O3/HNO3 (10.3-16.2) and O3/NOy (5.7-10.8) were adopted to assess the ozone sensitive regime at the three sites.The results indicated that the three transition ranges yield consistent results with CAMx simulations at most times at Pingtung City.However, both VOC-sensitive and NOx-sensitive regimes were important at the rural site Chao-Chou Town.Kenting Town, a touring site at the southern end of Taiwan, was predominated by a NOx-sensitive regime in four seasons.

  10. Deuteron-deuteron elastic scattering at high energies

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem; Ali, S. (Univ. of the Punjab, Lahore (Pakistan))

    1991-04-01

    The eikonal picture which has theoretical foundations in some areas of physics has been successful in explaining various aspects of elastic scattering at high energies. Chou and Yang first proposed a preliminary version of the eikonal model for hadron-hadron elastic scattering. The model is based on geometrical considerations in which hadrons are treated as extended objects. Elastic scattering then results from the propagation of attenuated wave function. By assuming that at high energies the scattering amplitude is purely imaginary and that the hadronic matter distribution is proportional to the charge distribution on protons, Durand and Lipes studied high energy pp scattering on the basis of this prestine model. Later on, the model was extended to other elastic reactions. However, a survey of literature shows that it has been successful only in the diffraction peak region. It has been shown that the pristine Chou-Yange model can explain the differential cross section for deuteron-deuteron elastic scattering at {radical}s = 53 GeV in the diffraction peak region. In order to fit the large momentum transfer data, the generalized Chou-Yang model is used.

  11. Spectrum of corrosive esophageal injury after intentional paraquat or glyphosate-surfactant herbicide ingestion

    Directory of Open Access Journals (Sweden)

    Chen HH

    2013-08-01

    Full Text Available Hsiao-Hui Chen,1 Ja-Liang Lin,1 Wen-Hung Huang,1 Cheng-Hao Weng,1 Shen-Yang Lee,1 Ching-Wei Hsu,1 Kuan-Hsing Chen,1 I-Kuan Wang,2 Chih-Chia Liang,2 Chiz-Tzung Chang,2 Tzung-Hai Yen1 1Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan; 2Department of Nephrology, China Medical University Hospital and China Medical University, Taichung, Taiwan Background: Data on the spectrum of corrosive injury to the esophagus after paraquat or glyphosate-surfactant ingestion are sparse in the literature and confined to case studies and brief reports. Therefore, this study aimed to examine the clinical features, degrees of esophageal injury, and clinical outcomes after paraquat or glyphosate herbicide ingestion, and sought to determine what association, if any, may exist between these findings. Methods: We performed an observational study on 47 patients with paraquat or glyphosate ingestion who underwent endoscopic evaluation over a period of 11 years (2000–2011. Results: Corrosive esophageal injuries were classified as grade 1 in 14 (glyphosate-surfactant and three (paraquat, grade 2a in nine (glyphosate-surfactant and 18 (paraquat, and grade 2b in one (glyphosate-surfactant and two (paraquat patients. No patients had grade 0, 3a, or 3b esophageal injuries. Therefore, the severity of corrosive injury was more severe in the paraquat group (P = 0.005. After toxin ingestion, systemic toxicity occurred, with rapid development of systemic complications in many cases. Neurologic complications occurred more frequently in the glyphosate-surfactant group (29.2% versus 0%, P = 0.005, although respiratory failure (4.2% versus 34.8%, P = 0.008, hepatitis (12.5% versus 52.2%, P = 0.004, and renal failure (20.8% versus 52.2%, P = 0.025 developed more frequently in the paraquat group. Patients with glyphosate poisoning had shorter hospital stays than patients with paraquat poisoning (13.3 ± 15

  12. Astronomical Orientation of Pyramid Tombs in North China

    Science.gov (United States)

    Rusell Tiede, Vance

    2010-01-01

    Two ancient Chinese texts, the Chou Bei Suan Ching and Chou Li (Western Han Dynasty, ca. 100 BC), record that the Imperial Astronomer (Feng Hsian Shin) made solar observations to determine the solstices and equinoxes, and for determining the cardinal directions with a circle and gnomon. By combining the techniques of astro-archaeology (G. S. Hawkins, 1968) with both overhead imagery and ground survey, the present study seeks to link historical Chinese descriptions of astronomical phenomena with contemporary architectural orientation. In the process, several unexpected astronomical orientation patterns emerged which apparently do not appear in the surviving historical record. For example, at the imperial Western Han capital of Ch'ang-an (N 34° latitude), the diagonals of cardinally oriented square pyramid mounds (ling) align to zenith (+34° declination) and nadir (-34° declination) star rise and set points on the skyline. This is in accord with the Chou (Zhou) Dynasty's name of Chung-Kuo, meaning Central Country or Middle Kingdom. That is, the imperial capital is centered both politico-geographically with respect to its vassal states of the Eastern Yi, Southern Man, Western Rong, and Northern Di, as well as astro-geomantically regarding the color-coded Five Sacred Directions East-South-West-North-Zenith/Nadir in the Cosmos. Our ground survey also confirmed pyramid orientation to the lunar standstills (+28°, +18° and +5° declination) that we reported from overhead imagery in 1980 (155th AAS Meeting, HAD 18.CE.12, Lunar and Solar Alignments of Ancient Chinese Pyramids). Grateful acknowledgment is given to the Chinese Academy of Sciences for the invitation to conduct an astro-archaeological survey of the Wei-ho valley, Shensi (Shaanxi) Province.

  13. A family-oriented treatment program for youths with ketamine abuse and their caregivers: a pilot study in Taiwan

    OpenAIRE

    Wang LJ; Lu SF; Chou WJ; Chong MY; Wang YH; Hsieh YL; Lee YH; Chen C

    2015-01-01

    Liang-Jen Wang,1 Shing-Fang Lu,1 Wen-Jiun Chou,1 Mian-Yoon Chong,2 Yao-Hsing Wang,1 Yu-Lian Hsieh,1 Yi-Hsuan Lee,1 Ching Chen2 1Department of Child and Adolescent Psychiatry, 2Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Objective: The abuse of ketamine by youths has grown into a serious public health issue. However, a reliable and efficient treatment has still not been found for youths who abuse ketamine. ...

  14. Lumbar facet injection for the treatment of chronic piriformis myofascial pain syndrome: 52 case studies

    OpenAIRE

    Huang JT; Chen HY; Hong CZ; Lin MT; Chou LW; HS; Chen; Tsai CT; Chang WD

    2014-01-01

    Jen-Ting Huang,1 Han-Yu Chen,2 Chang-Zern Hong,2 Ming-Ta Lin,3 Li-Wei Chou,4,5 Hsin-Shui Chen,6,7 Chien-Tsung Tsai,8 Wen-Dien Chang9  1Department of Orthopedic Surgery, Taichung Veterans General Hospital, 2Department of Physical Therapy, Hung-Kuang University, Sha Lu, 3Kuan-Ta Rehabilitation and Pain Clinic, Taichung, Taiwan; 4Department of Physical Medicine and Rehabilitation, China Medical University Hospital, 5School of Chinese Medicine, College of Chinese Medicine, Chin...

  15. Chronic shoulder pain referred from thymic carcinoma: a case report and review of literature

    OpenAIRE

    Dee SW; Kao MJ; Hong CZ; Chou LW; Lew HL

    2012-01-01

    Shu-Wei Dee,1 Mu-Jung Kao,2,3 Chang-Zern Hong,4 Li-Wei Chou,1,5 Henry L Lew6,71Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, 2Department of Physical Medicine and Rehabilitation, Yangming Branch, Taipei City Hospital, Taipei, 3Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, 4Department of Physical Therapy, Hungkuang University, Taichung, 5School of Chinese Medicine, College of Chinese Medicine, C...

  16. Characterization of the alpha and beta subunits of casein kinase 2 by far-UV CD spectroscopy

    DEFF Research Database (Denmark)

    Issinger, O G; Brockel, C; Boldyreff, B;

    1992-01-01

    Although Chou-Fasman calculations of the secondary structure of recombinant casein kinase 2 subunits alpha and beta suggest they have a similar overall conformation, circular dichroism (CD) studies show that substantial differences in the conformation of the two subunits exist. In addition......, no changes in the far-UV CD spectrum of the alpha subunit are observed in the presence of casein or the synthetic decapeptide substrate RRRDDDSDDD. Furthermore, the alpha-helical structure of the alpha subunit (but not the beta subunit) can be increased in the presence of stoichiometric amounts of heparin...

  17. Anibamine and its Analogues as Novel Anti-Prostate Cancer Agents

    Science.gov (United States)

    2009-06-01

    structural studies of the CB1 cannabinoid receptor . J. Pept. Res. 2002, 60 (6), 348–56. (26) (a) Sirois, S.; Wei, D. Q.; Du, Q. S.; Chou, K. C. Virtual...Investigation of the impact of chemokine receptor CCR5 antagonist on prostate cancer cell growth and progression using M 12, PC-3, DU-145 and LNCa P... receptor CCR5, to further facilitate our next generation molecular design. This part of work has been published in the Journal of Che mical Informatics

  18. Ultra High Energy Density Cathodes with Carbon Nanotubes

    Science.gov (United States)

    2013-12-10

    34Enhanced Capacity and Rate Capability of Carbon Nanotube Based Anodes with Titanium Contacts for Lithium Ion Batteries," ACS Nano, vol. 4, pp. 6121- 6131...2010/10/26 2010. [2] S. L. Chou, et al., "Silicon/Single-Walled Carbon Nanotube Composite Paper as a Flexible Anode Material for Lithium Ion...AFRL-RV-PS- AFRL-RV-PS- TR-2013-0170 TR-2013-0170 ULTRA HIGH ENERGY DENSITY CATHODES WITH CARBON NANOTUBES Brian J. Landi, et al. Rochester

  19. Using Wave-Current Observation to Predict Bottom Sediment Processes on Muddy Beaches

    Science.gov (United States)

    2011-09-30

    hypothesized stages of bed evolution: (A) solid bed; (B) breaking of the bed matrix and water absorption (liquefaction/ fluidization /expansion); (C) bed erosion...Geophys. Res. Lett. 35/7, L07611. Foda, A.M., J.R. Hunt, and H.-T. Chou (1993). A nonlinear model for the fluidization of marine mud by waves, J...Geophys. Res. 98, 7039-7047. Foda M.A. and S.Y., Tzang (1994). Resonant fluidization of silty soil by water waves, J. Geophys. Res. 99(C10), 20463

  20. Mathematical Viscosity Models for Ternary Metallic and Silicate Melts

    Institute of Scientific and Technical Information of China (English)

    FU Yuan-kun; MENG Xian-min; GUO Han-jie

    2004-01-01

    The mathematical viscosity models for metallic melts were discussed. The experimental data of Ag-Au-Cu systems were used to verify the models based on Chou's general geometric thermodynamic model and the calculated results are consistent with the reported experimental data. A new model predicting the viscosity of multi-component silicate melts was established. The CaO-MnO-SiO2, CaO-FeO-SiO2 and FeO-MnO-SiO2 silicate slag systems were used to verify the model.

  1. Semi-transparent hadrons from multi-channel absorption effects

    CERN Document Server

    Fialkowski, K

    1976-01-01

    The absorption structure of diffractive dissociation is analyzed and the elastic and inelastic processes discussed simultaneously. This approach is motivated by their close interdependence and mutual influence. It is shown that the results differ significantly from the standard picture of elastic scattering. In particular, protons are shown to have very rich internal structure coupling both to 'black' and 'transparent' diffractive scattering eigenstates. Proton matter distribution may well be very different from that suggested by the analysis of Chou and Yang (1968). Finally, the indicated asymptotic behaviour is that of a 'grey' instead of a 'black' disc limit. (18 refs).

  2. Equivalent Activity Coefficient Phenomenon of Cerium Reacting with Lead or Bismuth in Ag, Cu and Zn Alloy

    Institute of Scientific and Technical Information of China (English)

    薛松柏; 钱乙余; 董健

    2002-01-01

    The relation between contents of cerium and impurity lead or bismuth to their activity coefficient in Ag, Cu and Zn-base alloy was calculated and analyzed by using the ternary system Chou model. The thermodynamic calculation results show that the "equivalent activity coefficient phenomenon" emerges among the activity coefficient of solute in a certain range of cerium (or at a certain point) for the Ce-Pb-X and Ce-Bi-X (X=Ag, Cu or Zn) ternary alloy system. Under this condition, the activity coefficient of solute has nothing to do with its own concentration. The preliminary theoretical analysis to this phenomenon was also made.

  3. Object-Oriented Database Access from Ada

    Science.gov (United States)

    1993-03-01

    programs’ sizes in Ada are larger than C’s. Strong type checking and the interface programs added overhead can probably explain this. 4.3 Problema ...Verdix Corporation. Verdix Ada Development System, 1991. BIB-2 Vita Lt Col Li Chou (ROCAF, Taiwan ) was born on 28 October 1957 in I-Lan, Taiwan ...Republic of China . He graduated from high school in I-Lan in June, 1975. He then entered the National Defense Medical Center from which he graduated in 1980

  4. Manufacturable Tri-Stack AlSb/InAs HEMT Low-Noise Amplifiers Using Wafer-Level-Packaging Technology for Light-Weight and Ultralow-Power Applications

    Science.gov (United States)

    2009-05-01

    CA, USA yeong-chang.chou@ngc.com J. B. Boos, B. R. Bennett, and N. A. Papanicolaou Naval Research Laboratory Washington DC, USA boos...introduce negative factors to affect RF yield and performance of power amplifiers, switches, and phase shifters. Figure 7 shows the on-wafer rf...Barsky, J. B. Boos, B. R. Bennett, J. L. Lee, N. A. Papanicolaou et al., “Metamorphic AlSb/InAs HEMTs for low-power, high-speed electronics,” the

  5. Hole Mobility Enhancement in In0.41Ga0.59Sb Quantum-Well Field-Effect Transistors

    Science.gov (United States)

    2011-01-01

    exponentially on VGS. 15 Therefore, for VGS−VT kT /q, IDsub h exp − qVGS − VT nkT , 1 where n is the ideality factor , k is the Boltzmann constant, T is...2009, 861. 2J. B. Boos, B. R. Bennett, N. A. Papanicolaou , M. G. Ancona, J. G. Champlain, R. Bass, and B. V. Shanabrook, Electron. Lett. 43, 834 2007...042104 2007. 10J. B. Boos, B. R. Bennett, N. A. Papanicolaou , M. G. Ancona, J. G. Champlain, Y.-C. Chou, M. D. Lange, J. M. Yang, R. Bass, D. Park

  6. Thermodynamic investigations on the component dependences of high-entropy alloys

    Science.gov (United States)

    Arslan, Huseyin; Dogan, Ali

    2016-12-01

    In the present research, a study on the thermodynamical properties of the quinary Co-Cu-Cr-Fe-Ni high-entropy alloys and ternary Ca-Sb-Yb is carried out by the models Kohler, Chou's general solution method (GSM) and Muggianu. The dependences of composition variation on thermodynamic properties, such as enthalpy of mixing of Co-Cu-Cr-Fe-Ni alloys in simple FCC phase are investigated at the temperatures 1273, 1373, and 1473 K. Moreover, a comparison between the results of the three models and those of other theoretical models shows good mutual agreement.

  7. Models to estimate viscosities of ternary metallic melts and their comparisons

    Institute of Scientific and Technical Information of China (English)

    王习东; 李文超

    2003-01-01

    Three models, based on Chou's general geometric thermodynamic model, to predict the viscosity of ternary metallic melts have been established. The calculation equations of the model have been deduced. The experimental viscosity data of Ag-Au-Cu systems were used to verify the models and the calculation results with the models are consistent with the reported experimental data. The advantages, requirement and applicability of the models have been analyzed and compared. The models have also been utilized to predict the viscosity of Ag-Sn-Cu system. The viscosity of the system was experimentally measured and the results are consistent with the calculated value of the models.

  8. Pattern recognition in speech and language processing

    CERN Document Server

    Chou, Wu

    2003-01-01

    Minimum Classification Error (MSE) Approach in Pattern Recognition, Wu ChouMinimum Bayes-Risk Methods in Automatic Speech Recognition, Vaibhava Goel and William ByrneA Decision Theoretic Formulation for Adaptive and Robust Automatic Speech Recognition, Qiang HuoSpeech Pattern Recognition Using Neural Networks, Shigeru KatagiriLarge Vocabulary Speech Recognition Based on Statistical Methods, Jean-Luc GauvainToward Spontaneous Speech Recognition and Understanding, Sadaoki FuruiSpeaker Authentication, Qi Li and Biing-Hwang JuangHMMs for Language Processing Problems, Ri

  9. Pseudomembranous colitis within radiotherapy field following concurrent chemoradiation therapy: a case report

    OpenAIRE

    2013-01-01

    Bing-Jie Shen,1 Shih-Chiang Lin,2 Pei-Wei Shueng,1,3 Yueh-Hung Chou,4 Li-Ming Tseng,5 Chen-Hsi Hsieh1,6,71Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Division of Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan; 3Department of Radiation Oncology, National Defense Medical Center, Taipei, Taiwan; 4Department of Anatomical Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan; 5...

  10. Effectively managing intractable central hyperthermia in a stroke patient by bromocriptine: a case report

    OpenAIRE

    2013-01-01

    Kuo-Wei Yu,1,* Yu-Hui Huang,2,3 Chien-Lin Lin,1,4,* Chang-Zern Hong,5 Li-Wei Chou1,41Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 3Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan; 4School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 5Department of Physical ...

  11. Thermodynamic Assessment of Interaction Relation between Lanthanum and Constituent Elements in Sn-Pb Alloy

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The interaction relation between lanthanum and the constituent elements of Sn-Pb alloy system was analyzed by using the thermodynamic models including Miedema formation energy model for binary system, Tanaka modification by excess entropy and the Chou geometric model for ternary system. The thermodynamic calculaton results show that lanthanum has higher affinity for Sn in the Sn-Pb system. This is an important foundation for the improvement of the metallurgical properties of Sn-Pb solder alloy by adding rare earth elements.

  12. Form factors of charged hadrons and quantum chromodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Saleem, M.; Fazal-e-Aleem; Rashid, H.; Azhar, I.A.; Rafique, M.

    1988-07-01

    A new parametrization G/sup New//sub p/ of the proton form factor is proposed. It is shown that this and the conventional parametrization G/sup V//sub ..pi../ = (1-t/m/sup 2//sub p/)/sup -1/ of the pion form factor are consistent with the experimental data wherever available, with lattice-QCD-based computations for small -t, and with perturbative QCD calculations for large -t. The hyperon form factors computed by using lattice QCD are also parametrized. The features of these form factors most relevant to the Chou-Yang Model are also discussed.

  13. Nucleas (hadron) nucleus elastic scattering and geometrical picture

    Energy Technology Data Exchange (ETDEWEB)

    Aleem F.; Ali, S.; Saleem, M. [Univ. of the Punjab, Lahore (Pakistan)

    1995-08-01

    A comprehensive explanation of nucleus-nucleus and hadron-nucleus elastic scattering is elusive ever since the measurements of these reactions were made. By proposing energy dependent hadronic form factors for deuteron and alpha, in analogy to that of the proton as suggested by Chou and Yang recently, the authors have fitted all the available data for alpha-alpha and deuteron-deuteron elastic scattering. In order to further verify the validity of the proposed form factor, they have also fitted the data for proton-alpha and proton-deuteron elastic scattering. It is concluded that the hadronic matter is expanding with an increase in energy. 30 refs., 11 figs.

  14. Modeling of Mud-Wave Interaction: Mud-Induced Wave Transport & Wave-Induced Mud Transport

    Science.gov (United States)

    2007-11-01

    seabed. This can be a fairly rapid process (i.e. of the order of tens of seconds, up to a few minutes at most, e.g. Foda and Zhang (1994); Lindenberg...response of cohesive sediments to water waves, PhD-dissertation, University of California, Berkeley, USA. Chou, H.-T., M.A. Foda and J.R. Hunt, 1993...Dingemans, M.W., 1997, Water wave propagation over uneven bottoms; Part I & II, World Scientific, Singapore. Foda , M.A. and S.-Y. Tzang, 1994

  15. Classical universe emerging from quantum cosmology without horizon and flatness problems

    Energy Technology Data Exchange (ETDEWEB)

    Fathi, M.; Jalalzadeh, S. [Shahid Beheshti University, Department of Physics, Tehran (Iran, Islamic Republic of); Moniz, P.V. [Centro de Matematica e Aplicacoes-UBI, Covilha (Portugal); Universidade da Beira Interior, Departmento de Fisica, Covilha (Portugal)

    2016-10-15

    We apply the complex de Broglie-Bohm formulation of quantum mechanics in Chou and Wyatt (Phys Rev A 76: 012115, 2007), Gozzi (Phys Lett B 165: 351, 1985), Bhalla et al. (Am J Phys 65: 1187, 1997) to a spatially closed homogeneous and isotropic early universe whose matter contents are radiation and dust perfect fluids. We then show that an expanding classical universe can emerge from an oscillating (with complex scale factor) quantum universe without singularity. Furthermore, the universe obtained in this process has no horizon or flatness problems. (orig.)

  16. Prediction of B Cell Epitope of DMRT Protein in Oreochromis niloticus%尼罗罗非鱼DMRT蛋白 B细胞表位的预测

    Institute of Scientific and Technical Information of China (English)

    杨东; 刘红艳; 张繁荣; 余来宁

    2008-01-01

    [Objective] The research aimed to predict the B cell epitope of DMRT protein in Oreochromis niloticus. [Method] The secondary structure of amino acid sequence of DMRT protein was revealed by Garnier-Robson, Chou-Fasman and Karplus-Schulz methods. The hydrophilicity plot, surface probability and antigenic index were obtained by Kyte-Doolittle, Emini and Jameson-Wolf methods, respectively. Based on the above results, the B cell epitopes for DMRT were predicted. [Result] Both the prediction results from Garnier-Robson, Chou-Fasman methods indicated that the α-helix centers of DMRT protein in O. niloticus were in the N terminal No. 31-56, 68-75, 110-116, 209-211 and 239-243; the β-sheet centers of DMRT protein in O. niloticus were in the N terminal No. 95-99, 177-183, 225-234 and 251-254. With the assistant of Kyte-Doolittle, Emini and Jameson-Wolf methods, the B cell epitopes for DMRT were located in or nearby the N terminal No. 13-16, 35-38, 47-54,84-93, 101-109, 127-156, 166-177 and 198-201. [Conclusion] These results are helpful for preparing the antibody of DMRT protein and revealing the sex determination mechanism of O. niloticus.

  17. Molecular Phylogenetic Analysis of the Main Lineages of Nymphalinae (Nymphalidae: Lepidoptera) Based on the Partial Mitochondrial COI Gene

    Institute of Scientific and Technical Information of China (English)

    ZHANG Min; CAO Tian-wen; ZHONG Yang; REN Zhu-mei; GUO Ya-ping; MA En-bo

    2008-01-01

    The phylogenetic relationships of the subfamily Nymphalinae (sensu Chou 1994) were analyzed based on 1488bp of mtDNA cytochrome oxidase subunit I (COI) gene sequence data obtained from 24 individuals, along with those of eight species obtained from GenBank. The base compositions of this COI fragment varied among the individuals as follows: T 39.9%, C 14.6%, A 32.2%, and G 13.4%, with a strong AT bias (72.1%), as usually found in insect mitochondrial genomes. The A+T contents of the third, second, and first codon positions of the COI fragments in this study was 92.4, 62.2, and 61.4%, respectively. The phylogenetic trees were reconstructed by neighbor-joining (NJ), maximum likelihood (ML), and Bayesian methods by using Byblia anvatara as outgroup. Phylogenetic analyses based on the COI gene sequence data created very similar topologies, which were producing trees with two main clades A and B, and five subclades. The data indicated that the tribes Nymphalini and Hypolimni (sensu Chou 1994) are not monophyletic groups, and the genus Junonia should be removed from Nymphalini to Hypolimni (=Junoniini). On the basis of the data, the Symbrenthia and Araschnia had a relative distant relationship with the rest of Nymphalini. The relationships of species in the Nymphalini were confirmed via the NJ, ML, and Bayesian methods, namely ((((Nymphalis+Kaniska)+Polygonia)+Aglais)+Vanessa)+(Symbrenthia+Araschnia). This investigation provides a little novel information for Chinese researches of butterflies.

  18. PCA for predicting quaternary structure of protein

    Institute of Scientific and Technical Information of China (English)

    Tong WANG; Hongbin SHEN; Lixiu YAO; Jie YANG; Kuochen CHOU

    2008-01-01

    The number and arrangement of subunits that form a protein are referred to as quaternary structure. Knowing the quaternary structure of an uncharacterized protein provides clues to finding its biological function and interaction process with other molecules in a biological system. With the explosion of protein sequences generated in the Post-Genomic Age, it is vital to develop an automated method to deal with such a challenge. To explore this prob-lem, we adopted an approach based on the pseudo position-specific score matrix (Pse-PSSM) descriptor, proposed by Chou and Shen, representing a protein sample. The Pse-PSSM descriptor is advantageous in that it can combine the evolution information and sequence-correlated informa-tion. However, incorporating all these effects into a descriptor may cause 'high dimension disaster'. To over-come such a problem, the fusion approach was adopted by Chou and Shen. A completely different approach, linear dimensionality reduction algorithm principal component analysis (PCA) is introduced to extract key features from the high-dimensional Pse-PSSM space. The obtained dimension-reduced descriptor vector is a compact repre-sentation of the original high dimensional vector. The jack-knife test results indicate that the dimensionality reduction approach is efficient in coping with complicated problems in biological systems, such as predicting the quaternary struc-ture of proteins.

  19. Thermodynamic calculation of intermetallic compounds in AZ91 alloy containing calcium

    Institute of Scientific and Technical Information of China (English)

    WU Yu-feng; DU Wen-bo; NIE Zuo-ren; CAO Lin-feng; ZUO Tie-yong

    2006-01-01

    Based on the Miedema model and Chou model, the activities of different solute components in Mg-Al-Zn, Mg-Ca-Zn and Mg-Al-Ca ternary systems were calculated. The results show that the variety of zinc content has little influence on the activity of Al or Ca, and the interaction of Zn and Al or Ca can be neglected when the mass fraction of Zn is lower than 2% in the AZ91 alloy containing calcium (noted as Mg-Al-Zn-Ca system). Therefore, the possible intermetallic compounds in the Mg-Al-Zn-Ca system can be predicted by directly calculating the Gibbs free energies of the reactions in Mg-Al-Ca system. The calculated Gibbs free energies in the Mg-Al-Ca system indicate that Al2Ca phase can take priority of depositing, which agrees with the experimental results in references. The consistency of calculation and experiment proves that the intermetallic compounds in the Mg-Al-Zn-Ca system can be predicted by the Miedema model and Chou model.

  20. Faults in Linux

    DEFF Research Database (Denmark)

    Palix, Nicolas Jean-Michel; Thomas, Gaël; Saha, Suman

    2011-01-01

    In 2001, Chou et al. published a study of faults found by applying a static analyzer to Linux versions 1.0 through 2.4.1. A major result of their work was that the drivers directory contained up to 7 times more of certain kinds of faults than other directories. This result inspired a number...... of development and research efforts on improving the reliability of driver code. Today Linux is used in a much wider range of environments, provides a much wider range of services, and has adopted a new development and release model. What has been the impact of these changes on code quality? Are drivers still...... a major problem? To answer these questions, we have transported the experiments of Chou et al. to Linux versions 2.6.0 to 2.6.33, released between late 2003 and early 2010. We find that Linux has more than doubled in size during this period, but that the number of faults per line of code has been...

  1. Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: experimental design and data analysis using the combination index method.

    Science.gov (United States)

    Zhang, Ning; Fu, Jia-Ning; Chou, Ting-Chao

    2016-01-01

    This brief article focuses on two aims: i) To investigate the in vitro pharmaco-dynamic interactions of combining synthetic potent microtubule targeting anticancer agent, Fludelone (FD) with cyto-protective agent, Panaxytriol (PXT) derived from Panax ginseng, and ii) To illustrate step-by-step operation for conducting two-drug combination in vitro using the combination index method, in terms of experimental design, data acquisition, computerized simulation and data interpretation. The Chou-Talalay method for drug combination is based on the median-effect equation, which provides the theoretical basis for the combination index (CI)-isobologram equation that allows quantitative determination of drug interactions, where CI1 indicates synergism, additive effect and antagonism, respectively. Based on these algorithms, computer software, CompySyn, is used for determining synergism and antagonism at all doses or effect levels simulated automatically. The use of Chou-Talalay's CI method in quantifying synergism or antagonism is increasing steadily during the past two decades, however, confusing questions and pitfalls were still frequently raised by insufficient understanding of the theory, especially reflected when researchers trying to use the computerized software to design and conduct experiments. In order to specifically address the confusions and to illustrate the practical features of this method, in this paper, a selected example is given based on our unpublished data regarding the combinational pharmacologic interactions of FD and PXT against the growth of breast cancer cell line MX-1. The step-by-step operation from experimental design to the real data analysis is illustrated. The results indicated that FD and PXT combination in vitro exerted synergistic effect when cell growth inhibition was greater than 45%, with CI ranged 0.836-0.609 for the fractional inhibition of Fa=0.50~0.90, as shown by the Fa-CI plot and by the isobologram. Thus, quantitative conclusion

  2. Google Scholar is not enough to be used alone for systematic reviews.

    Science.gov (United States)

    Giustini, Dean; Boulos, Maged N Kamel

    2013-01-01

    Google Scholar (GS) has been noted for its ability to search broadly for important references in the literature. Gehanno et al. recently examined GS in their study: 'Is Google scholar enough to be used alone for systematic reviews?' In this paper, we revisit this important question, and some of Gehanno et al.'s other findings in evaluating the academic search engine. The authors searched for a recent systematic review (SR) of comparable size to run search tests similar to those in Gehanno et al. We selected Chou et al. (2013) contacting the authors for a list of publications they found in their SR on social media in health. We queried GS for each of those 506 titles (in quotes "), one by one. When GS failed to retrieve a paper, or produced too many results, we used the allintitle: command to find papers with the same title. Google Scholar produced records for ~95% of the papers cited by Chou et al. (n=476/506). A few of the 30 papers that were not in GS were later retrieved via PubMed and even regular Google Search. But due to its different structure, we could not run searches in GS that were originally performed by Chou et al. in PubMed, Web of Science, Scopus and PsycINFO®. Identifying 506 papers in GS was an inefficient process, especially for papers using similar search terms. Has Google Scholar improved enough to be used alone in searching for systematic reviews? No. GS' constantly-changing content, algorithms and database structure make it a poor choice for systematic reviews. Looking for papers when you know their titles is a far different issue from discovering them initially. Further research is needed to determine when and how (and for what purposes) GS can be used alone. Google should provide details about GS' database coverage and improve its interface (e.g., with semantic search filters, stored searching, etc.). Perhaps then it will be an appropriate choice for systematic reviews.

  3. Contributions en faveur d'une meilleure personnalisation de la recherche d'informations - Applications à la tâche questions-réponses, à la recherche de documents audio et à l'accessibilité pour des personnes dyslexiques

    OpenAIRE

    Bellot, Patrice

    2008-01-01

    Dans un article récent sur les enjeux de la recherche d'informations, Belkin (2008) rappelle que la question de la personnalisation est annoncée comme majeure depuis une vingtaine d'années mais que la plupart des tentatives vers une étude systématique ont échoué. S'il n'est pas question de prétendre que les évaluations TREC Interactive puis TREC Hard et TREC ciQA, pour ne mentionner qu'elles, n'ont abouti à rien dans ce domaine, force est de constater que l'utilisateur n'intervient que très p...

  4. Réinventer la géodiversité

    Directory of Open Access Journals (Sweden)

    Denise Pumain

    1999-12-01

    Full Text Available L'année 1999 s'achève. Dans le passage des chiffres neuf aux chiffres ronds, il n'entre guère semble-t-il de frayeur millénariste, bogues informatiques exceptés ! Espérons que cette nouvelle ligne de changement de date nous épargnera, davantage que les malheureux passagers du navire échoué sur l'île du jour d'avant chez Umberto Eco. L'année écoulée laisse aux rivages de janvier une écume géographique de faits éclectiques, sur fond de mise en réseau - mise au pas planétaire, tant furent portée...

  5. The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture.

    Science.gov (United States)

    Del Rio, Beatriz; Redruello, Begoña; Linares, Daniel M; Ladero, Victor; Fernandez, Maria; Martin, Maria Cruz; Ruas-Madiedo, Patricia; Alvarez, Miguel A

    2017-03-01

    Tyramine and histamine are the biogenic amines (BA) most commonly found at high concentrations in food; they may even appear together at toxic concentrations. The present work examines, via real-time cell analysis, whether histamine and tyramine show synergistic toxicity towards intestinal cell cultures. Employing a constant equipotency ratio, their interaction was examined via the combination index (CI) method of Chou & Talalay. Co-treatment with tyramine and histamine was associated with a stronger cytotoxic effect than was treatment with either BA or on its own. Indeed, a synergistic interaction (CIhistamine, at concentrations below the legal limit, increases the cytotoxicity of tyramine at concentrations frequently reached in some foods. The synergistic cytotoxicity of tyramine and histamine should be taken into account when establishing legal limits designed to ensure consumer safety.

  6. The Orang Suku Laut of Riau, Indonesia

    DEFF Research Database (Denmark)

    Chou, Cynthia Gek Hua

    Land reform has been an indisputable part of Indonesian revolution. The consequent execution of development programmes for nation-building have provoked intense hostility over territorial rights. Global market forces in Indonesia have seen increasing flows of transnational investments, technology...... and resources that have resulted in great demand on sea and land spaces. In this momentum of change, several aspects of rural culture including indigenous populations, like the Orang Suku Laut (people of the sea) of Riau have been deemed by the state architects of development programmes to hinder progress...... the social assimilation of indigenous peoples as citizens, religious conversion and cultural identity. Cynthia Chou discusses how Indonesian nation-building development programmes have generated intense struggles over issues pertaining to territorial rights, social assimilation of indigenous peoples...

  7. Managing fatigue in patients with Parkinson's disease: a patient-focused perspective

    Directory of Open Access Journals (Sweden)

    Ridder A

    2016-07-01

    Full Text Available Andrew Ridder,1 Kelvin L Chou,1,2 1Department of Neurology, 2Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA Abstract: Fatigue, experienced as a significantly diminished energy level or an increased perception of effort disproportionate to attempted activities or general activity level, is being increasingly recognized as a common and disabling problem in patients with Parkinson’s disease. There are no commonly accepted criteria to diagnose fatigue in Parkinson’s disease and there is limited evidence regarding treatment of this symptom. This article reviews the current knowledge surrounding fatigue in Parkinson’s disease, including symptoms, epidemiology, diagnosis, and treatment, with a focus on the patient’s perspective. Keywords: Parkinson’s disease, fatigue, diagnosis, treatment

  8. Support vector machines for prediction of protein signal sequences and their cleavage sites.

    Science.gov (United States)

    Cai, Yu-Dong; Lin, Shuo-liang; Chou, Kuo-Chen

    2003-01-01

    Given a nascent protein sequence, how can one predict its signal peptide or "Zipcode" sequence? This is an important problem for scientists to use signal peptides as a vehicle to find new drugs or to reprogram cells for gene therapy (see, e.g. K.C. Chou, Current Protein and Peptide Science 2002;3:615-22). In this paper, support vector machines (SVMs), a new machine learning method, is applied to approach this problem. The overall rate of correct prediction for 1939 secretary proteins and 1440 nonsecretary proteins was over 91%. It has not escaped our attention that the new method may also serve as a useful tool for further investigating many unclear details regarding the molecular mechanism of the ZIP code protein-sorting system in cells. Copyright 2002 Elsevier Science Inc.

  9. Claude Morange, Una conspiración fallida y una Constitución nonnata (1819

    Directory of Open Access Journals (Sweden)

    Pierre Géal

    2008-04-01

    Full Text Available Pour qui ne serait pas familier du Sexenio absolutista, le sujet d’étude choisi ici par Claude Morange peut sembler de prime abord parfaitement anecdotique : à quoi bon s’intéresser à l’une des multiples conspirations qui échouèrent entre 1814 et 1820, et à un projet de constitution qui resta secret ? L’historien ne serait-il pas tombé ici dans les travers d’une vaine érudition en se consacrant à une question mineure ?Dès les premières pages, pourtant, le bien-fondé de cette enquête s’impose ...

  10. 永恒的和谐

    Institute of Scientific and Technical Information of China (English)

    李甜; 思齐

    2007-01-01

    位于美国密苏里州堪萨斯城中心的Nelson- Atkins艺术博物馆始建于1933年,它是世界知名的艺术殿堂,里面收藏着大量艺术珍品,如:Chiang Shen的群山图(12世纪)和Chou C(?)hen的北海图(16世纪)等。1999年,Nelson-Atkins艺术博物馆由世界著名建筑事务所Steven Holl担纲设计开始扩建,最终于今年6月落成了最后一幢新建筑。至此,包括雕塑园在内的新博物馆园区,占地总面积已达234.000平方英尺。

  11. 对《后汉书·延笃传》所载屈原庙遗迹的历史考察%The Historical Investigation on the Remains of Qu Yuan Temple in The History of the Later Han Dynasty·The Biography of Yan Du

    Institute of Scientific and Technical Information of China (English)

    钱征

    2015-01-01

    Qu Yuan Temple written in The History of the Later Han Dynasty·The Biography of Yan Du is the first time recorded in the official history. It is located in ancient Chou County, Pingdingshan City, Henan Province. In other words, the earliest remains of Quyuan Temple is in Lushan County Pingdingshan City, Henan Province.%《后汉书·延笃传》所记载的屈原庙,系正史所载最早的。其地域在今河南平顶山市。古犨县,在今鲁山县境内。也就是说,最早的屈原庙遗迹,在今河南省平顶山市鲁山县境内。

  12. Cryptanalysis and improvement of a quantum communication-based online shopping mechanism

    Science.gov (United States)

    Huang, Wei; Yang, Ying-Hui; Jia, Heng-Yue

    2015-06-01

    Recently, Chou et al. (Electron Commer Res 14:349-367, 2014) presented a novel controlled quantum secure direct communication protocol which can be used for online shopping. The authors claimed that their protocol was immune to the attacks from both external eavesdropper and internal betrayer. However, we find that this protocol is vulnerable to the attack from internal betrayer. In this paper, we analyze the security of this protocol to show that the controller in this protocol is able to eavesdrop the secret information of the sender (i.e., the customer's shopping information), which indicates that it cannot be used for secure online shopping as the authors expected. Accordingly, an improvement of this protocol, which could resist the controller's attack, is proposed. In addition, we present another protocol which is more appropriate for online shopping. Finally, a discussion about the difference in detail of the quantum secure direct communication process between regular quantum communications and online shopping is given.

  13. Improvement of the Blast Furnace Viscosity Prediction Model Based on Discrete Points Data

    Science.gov (United States)

    Guo, Hongwei; Zhu, Mengyi; Li, Xinyu; Guo, Jian; Du, Shen; Zhang, Jianliang

    2015-02-01

    Viscosity is considered to be a significant indicator of the metallurgical property of blast furnace slag. An improved model for viscosity prediction based on the Chou model was presented in this article. The updated model has optimized the selection strategy of distance algorithm and negative weights at the reference points. Therefore, the extensionality prediction disadvantage in the original model was ameliorated by this approach. The model prediction was compared with viscosity data of slags of compositions typical to BF operations obtained from a domestic steel plant. The results show that the approach can predict the viscosity with average error of 9.23 pct and mean standard deviation of 0.046 Pa s.

  14. MODEL IMPROVEMENT AND EXPERI-MENT VALIDATION OF PNEUMATIC ARTIFICIAL MUSCLES

    Institute of Scientific and Technical Information of China (English)

    Zhou Aiguo; Shi Guanglin; Zhong Tingxiu

    2004-01-01

    According to the deficiency of the present model of pneumatic artificial muscles (PAM), a serial model is built up based on the PAM's essential working principle with the elastic theory, it is validated by the quasi-static and dynamic experiment results, which are gained from two experiment systems.The experiment results and the simulation results illustrate that the serial model has made a great success compared with Chou's model, which can describe the force characteristics of PAM more precisely.A compensation item considering the braid's elasticity and the coulomb damp is attached to the serial model based on the analysis of the experiment results.The dynamic experiment proves that the viscous damp of the PAM could be ignored in order to simplify the model of PAM.Finally, an improved serial model of PAM is obtained.

  15. Taxonomic updates and descriptions of four new Lophopini planthopper species (Hemiptera, Fulgoroidea, Lophopidae from Yunnan province, South China

    Directory of Open Access Journals (Sweden)

    Menglin Wang

    2016-03-01

    Full Text Available Taxonomic updates and descriptions of four new species from Yunnan, China are provided: three new species in the genus Pitambara Distant, 1906: P. triremiprocta Wang & Soulier-Perkins, sp. nov., P. impudica Wang & Bourgoin, sp. nov., P. tricorne Wang & Wang, sp. nov., and one new species in the genus Serida Walker, 1857: Serida parenthesisflexuosa Wang & Soulier-Perkins, sp. nov. A new identification key to Pitambara species is provided, as well as to the species of the genus Lacusa Stål, 1862. Lacusa yunnanensis Chou & Huang, 1985 stat. rev. is not considered as a synonym of the species L. fuscofasciata (Stål, 1854 anymore and Lacusa orientalis (Liang, 2000 is transferred to the genus Acothrura Melichar, 1915 as Acothrura orientalis (Liang, 2000 comb. nov.

  16. Clément Dessy, Valérie Stiénon, dirs, (Bé)vues du futur. Les imaginaires visuels de la dystopie (1840-1940)

    OpenAIRE

    Clément, Jean-Louis

    2017-01-01

    Le renseignement n’est pas donné, mais il apparaît, à la lecture, que cet ouvrage pourrait être la publication des actes d’un colloque dont le thème est pionnier : l’étude des dystopies qui sont des utopies ayant échoué ainsi que l’écrit avec pertinence Laurent Bazin (p. 229). Les utopies présentent l’Avenir comme un horizon radieux ; les dystopies le dénoncent sur le mode apocalyptique, étant entendu que les deux directeurs de l’ouvrage entendent ce mot dans son acception triviale et non dan...

  17. New results for antiproton-proton elastic scattering and various theoretical models

    Energy Technology Data Exchange (ETDEWEB)

    Fazal-e-Aleem; Saleem, M. (Centre for High Energy Physics, Punjab University, Lahore-54590, Pakistan (PK)); Yodh, G.B. (Department of Physics, University of California-Irvine, Irvine, CA 92717 (USA))

    1991-07-01

    The most recent measurements of the ratio {rho} of the real and imaginary parts of the forward-scattering amplitudes at 0.546 TeV, the total and elastic differential cross sections at 0.546 and 1.8 TeV for proton-antiproton scattering, are compared to the predictions of the generalized Chou-Yang and other theoretical models. For 1.8 TeV, the presence or absence of the break near {minus}{ital t}{approx}0.15 (GeV/{ital c}){sup 2} and of the dip in the vicinity of 0.6 (GeV/{ital c}){sup 2} are also discussed in the light of various predictions. The possibility of a further rise of the ratio {rho} at 1.8 TeV is also probed.

  18. 曼氏血吸虫28kDa谷胱甘肽S-转移酶的有效抗原肽P141结构与活性研究%Studies on Structure and Activity of Effective Antigenic Peptide P141 of 28kDa Glutathione S-Transferase of Schistosoma Mansoni

    Institute of Scientific and Technical Information of China (English)

    许家喜; 秦致辉; 易有云; 蔡孟深

    1999-01-01

    以曼氏血吸虫28kDa谷胱甘肽S-转移酶的有效抗原肽P141为先导肽,通过分别改变在结构上、Chou-Fasman构象参数上和亲水性上相似的氨基酸残基设计并合成了4个类似物,通过ELISA法测定了它们对血吸虫表膜抗原多克隆抗体的抗原性,通过类似物与P141的活性比较讨论了构效关系.

  19. Analysis of the secondary structure of a protein's N-terminal

    Science.gov (United States)

    Floare, C. G.; Bogdan, M.; Horovitz, O.; Mocanu, A.; Tomoaia-Cotisel, M.

    2009-08-01

    The major protein component from aleurone cells of barley (Hordeum vulgare L.), PACB, is related to 7S globulins present in other cereals and to the vicilin-type 7S globulins of legumes and cotton seed. It contains 4 subunits of about 20, 25, 40 and 50 kDa molecular weights. The N-terminal sequence of 16 amino acids (over 260 atoms) in the protein was previously determined, and our aim is the prediction of its secondary structure. The empirical Chou-Fasman method was applied in an improved version as well as the empirical DSC method (discrimination of protein secondary structure class) with quite similar results. A molecular dynamics simulation was also performed, using the FF99SB forcefield within AMBER version 9.0. Solvation effects were incorporated using the Born model. The results are compared and a 3D model is proposed.

  20. Analysis of the secondary structure of a protein's N-terminal

    Energy Technology Data Exchange (ETDEWEB)

    Floare, C G; Bogdan, M [National Institute for R and D of Isotopic and Molecular Technologies, 65-103 Donath, 400293 Cluj-Napoca (Romania); Horovitz, O; Mocanu, A; Tomoaia-Cotisel, M, E-mail: calin.floare@itim-cj.r [Babes-Bolyai University, Faculty of Chemistry and Chemical Engineering, Department of Physical Chemistry, 11 Arany Janos, 400028 Cluj-Napoca (Romania)

    2009-08-01

    The major protein component from aleurone cells of barley (Hordeum vulgare L.), PACB, is related to 7S globulins present in other cereals and to the vicilin-type 7S globulins of legumes and cotton seed. It contains 4 subunits of about 20, 25, 40 and 50 kDa molecular weights. The N-terminal sequence of 16 amino acids (over 260 atoms) in the protein was previously determined, and our aim is the prediction of its secondary structure. The empirical Chou-Fasman method was applied in an improved version as well as the empirical DSC method (discrimination of protein secondary structure class) with quite similar results. A molecular dynamics simulation was also performed, using the FF99SB forcefield within AMBER version 9.0. Solvation effects were incorporated using the Born model. The results are compared and a 3D model is proposed.

  1. Acute macular edema following intracorporeal prostaglandin injection for erectile dysfunction

    Directory of Open Access Journals (Sweden)

    Asahi MG

    2015-07-01

    Full Text Available Masumi G Asahi, Calvin Chou, Ron P Gallemore Retina Macula Institute, Torrance, CA, USA Purpose: We aimed to describe the first case of macular edema following intracorporeal injection of alprostadil, a prostaglandin E1. Methods: This was a retrospective case report followed with optical coherence tomography, fundus photos, and fluorescein angiography images. Results: A patient developed bilateral cystoid macular edema following intracorporeal injection of alprostadil, a prostaglandin E1 for treatment of erectile dysfunction. The edema resolved following treatment with nonsteroidal anti-inflammatory drugs (NSAIDs and corticosteroids, with subsequent recovery in visual acuity. Discussion: Systemic prostaglandin administration can cause macular edema and vision loss, indicating that elevated systemic prostaglandin levels may affect visual function. This has potential implications for other systemic disorders and treatments that could affect macular function. Keywords: alprostadil, inflammation

  2. Le numérique, indispensable vecteur de la mobilité électrique ?

    OpenAIRE

    ESKENAZI, Manon; Pierre, Magali; Boutueil, Virginie; Escoffier, Caroline

    2016-01-01

    International audience; Dès les premiers temps de sa diffusion sur le marché de masse, la voiture fut considérée un symbole de modernité, vectrice d’innovations technologiques (Flonneau, 2003) et cette qualité contribua à son succès. A plusieurs reprises dans l’histoire de l’automobile, le véhicule électrique a échoué à s’imposer comme une innovation technologique désirable face à un véhicule thermique de plus en plus performant. Ces dernières années, il est redevenu un sujet d’intérêt pour l...

  3. Towards a model for protein production rates

    CERN Document Server

    Dong, J J; Zia, R K P

    2007-01-01

    In the process of translation, ribosomes read the genetic code on an mRNA and assemble the corresponding polypeptide chain. The ribosomes perform discrete directed motion which is well modeled by a totally asymmetric simple exclusion process (TASEP) with open boundaries. Using Monte Carlo simulations and a simple mean-field theory, we discuss the effect of one or two ``bottlenecks'' (i.e., slow codons) on the production rate of the final protein. Confirming and extending previous work by Chou and Lakatos, we find that the location and spacing of the slow codons can affect the production rate quite dramatically. In particular, we observe a novel ``edge'' effect, i.e., an interaction of a single slow codon with the system boundary. We focus in detail on ribosome density profiles and provide a simple explanation for the length scale which controls the range of these interactions.

  4. Towards a Model for Protein Production Rates

    Science.gov (United States)

    Dong, J. J.; Schmittmann, B.; Zia, R. K. P.

    2007-07-01

    In the process of translation, ribosomes read the genetic code on an mRNA and assemble the corresponding polypeptide chain. The ribosomes perform discrete directed motion which is well modeled by a totally asymmetric simple exclusion process (TASEP) with open boundaries. Using Monte Carlo simulations and a simple mean-field theory, we discuss the effect of one or two "bottlenecks" (i.e., slow codons) on the production rate of the final protein. Confirming and extending previous work by Chou and Lakatos, we find that the location and spacing of the slow codons can affect the production rate quite dramatically. In particular, we observe a novel "edge" effect, i.e., an interaction of a single slow codon with the system boundary. We focus in detail on ribosome density profiles and provide a simple explanation for the length scale which controls the range of these interactions.

  5. Screening among workers in a dockyard in the city of Varna

    Directory of Open Access Journals (Sweden)

    M. Milkov

    2011-03-01

    Full Text Available Hearing reduction and hearing loss are common among the industrial workers exposed to continuous and intensive occupational noise, although they are completely preventable. Hearing protection devices are more and more widely used in modern industry, however, they are not efficient enough. That is why preventive otorhinolaryngologic examinations should regularly been performed to enable the early diagnosis and timely treatment of this severe pathology. Several recent investigations deal with the damage of the medium and inner ear as well as of the hearing characteristics caused by intensive and longlasting industrial noise, especially in construction in the USA (Wu, et al., 1998; Edelson, et al., 2009, in dockyards (Sliwinska-Kowalska, et al., 2004; Zamyslowska-Szmytke, et al., 2007, in a liquefied petroleum gas cylinder infusion factory in Taiwan (Chang, et al., 2009, in a semiconductor factory (Chou, et al., 2009, in steel mills, lumber mills and marble shops in Brazil (Boger, et al., 2009, among truck drivers (Krishnamurti, 2009; Karimi, et al., 2010, etc. The combined harmful effects of workplace noise and various agents such as chemicals (Morata, et al., 1993; Sliwinska-Kowalska, et al., 2004; Sliwinska- Kowalska, et al., 2005 and heat (Singh, et al., 2010 are intensively studied, too. Binaurial hearing impairment caused by simultaneous exposure to occupational noise and cigarette smoke is proved, too (Mohammadi, et al., 2010. The role of shift-work on noise-induced hearing loss is emphasized (Borchgrevink, 2009; Chou, et al., 2009. The purpose of the present paper is to analyze the dynamics of hearing reduction of dockyard workers by twofold comprehensive screening examinations as a first step in a broad prevention programme.

  6. Combined Wavelet Video Coding and Error Control for Internet Streaming and Multicast

    Directory of Open Access Journals (Sweden)

    Tianli Chu

    2003-01-01

    Full Text Available This paper proposes an integrated approach to Internet video streaming and multicast (e.g., receiver-driven layered multicast (RLM by McCanne based on combined wavelet video coding and error control. We design a packetized wavelet video (PWV coder to facilitate its integration with error control. The PWV coder produces packetized layered bitstreams that are independent among layers while being embedded within each layer. Thus, a lost packet only renders the following packets in the same layer useless. Based on the PWV coder, we search for a multilayered error-control strategy that optimally trades off source and channel coding for each layer under a given transmission rate to mitigate the effects of packet loss. While both the PWV coder and the error-control strategy are new—the former incorporates embedded wavelet video coding and packetization and the latter extends the single-layered approach for RLM by Chou et al.—the main distinction of this paper lies in the seamless integration of the two parts. Theoretical analysis shows a gain of up to 1 dB on a channel with 20% packet loss using our combined approach over separate designs of the source coder and the error-control mechanism. This is also substantiated by our simulations with a gain of up to 0.6 dB. In addition, our simulations show a gain of up to 2.2 dB over previous results reported by Chou et al.

  7. Statistically significant dependence of the Xaa-Pro peptide bond conformation on secondary structure and amino acid sequence

    Directory of Open Access Journals (Sweden)

    Leitner Dietmar

    2005-04-01

    Full Text Available Abstract Background A reliable prediction of the Xaa-Pro peptide bond conformation would be a useful tool for many protein structure calculation methods. We have analyzed the Protein Data Bank and show that the combined use of sequential and structural information has a predictive value for the assessment of the cis versus trans peptide bond conformation of Xaa-Pro within proteins. For the analysis of the data sets different statistical methods such as the calculation of the Chou-Fasman parameters and occurrence matrices were used. Furthermore we analyzed the relationship between the relative solvent accessibility and the relative occurrence of prolines in the cis and in the trans conformation. Results One of the main results of the statistical investigations is the ranking of the secondary structure and sequence information with respect to the prediction of the Xaa-Pro peptide bond conformation. We observed a significant impact of secondary structure information on the occurrence of the Xaa-Pro peptide bond conformation, while the sequence information of amino acids neighboring proline is of little predictive value for the conformation of this bond. Conclusion In this work, we present an extensive analysis of the occurrence of the cis and trans proline conformation in proteins. Based on the data set, we derived patterns and rules for a possible prediction of the proline conformation. Upon adoption of the Chou-Fasman parameters, we are able to derive statistically relevant correlations between the secondary structure of amino acid fragments and the Xaa-Pro peptide bond conformation.

  8. Measurement of zinc activity in the ternary In–Zn–Sn alloys by EMF method

    Energy Technology Data Exchange (ETDEWEB)

    Behera, C.K., E-mail: ckbehera.met@itbhu.ac.in; Sonaye, A.

    2013-09-20

    Highlights: • Activity of zinc in the ternary In–Zn–Sn system has been measured in the temperature range 753–853 K by EMF method. • Isoactivity lines for zinc reflect the positive deviation from the ideality at 813 K. • The activity of indium in In–Sn binary system shows negative deviation from Raoult's law over entire range of composition. • Ternary excess molar free energies at 813 K are computed by Darken's treatment. • Calculated molar excess free energies for the ternary systems are compared with the Chou's theoretical model data. - Abstract: Activity of zinc in liquid In–Zn–Sn alloys has been measured by electrochemical technique based on molten salt electrolyte galvanic cell in the temperature range 753–853 K along three ternary sections of Zn{sub x}(In{sub y}Sn{sub 1−y}){sub 1−x} where y = 0.67, 0.50 and 0.33. The activity of indium in In–Sn binary alloys has also been measured by the same technique in the same temperature range. The activity of Zinc in In–Zn–Sn alloys shows positive deviation from the Raoult's law over entire range of composition. The activity of indium in In–Sn alloys shows negative deviations from ideality for entire composition. The excess molar free energies have been computed by the Darken's treatment of the ternary solutions using In–Sn binary data and ternary data in this study. Isoactivity curves at 813 K in the ternary In–Zn–Sn alloys were derived by combining the activity data of In–Zn and Sn–Zn alloys. The values of excess molar free energy in this study are in good agreement with those calculated from the general model calculation proposed by Chou.

  9. Effect of rehabilitation on a patient suffering from a tuberculous brain abscess with Gerstmann's syndrome: case report

    Directory of Open Access Journals (Sweden)

    Kuo CL

    2012-05-01

    Full Text Available Chih-Lan Kuo1, Sui-Foon Lo1,2, Chun-Lin Liu3, Chia-Hui Chou4, Li-Wei Chou1,2,5¹Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; ²School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 3Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan; 4Department of Infectious disease, China Medical University Hospital, Taichung, Taiwan; 5Department of Physical Therapy, China Medical University, Taichung, TaiwanAbstract: There are few reports in the literature of tuberculous brain abscess. Tuberculous brain abscess usually occurs in an immunocompromised host. Almost all previously documented cases have involved acquired immune deficiency syndrome. We encountered a 53-year-old right-handed immunocompetent male who was initially suspected of having a cerebrovascular accident due to acute-onset right hemiparesis and paresthesia. A tentative diagnosis of brain tumor versus brain abscess was made on imaging studies. The patient was finally diagnosed with a tuberculous brain abscess based upon deterioration on imaging and a positive tuberculosis culture. The tuberculous brain abscess was located in the left parietal lobe, which resulted in Gerstmann's syndrome and right-sided apraxia. Stereotactic surgery was performed. He was also given antituberculosis chemotherapy and comprehensive rehabilitation. Considerable improvement was noted after rehabilitation. The patient even returned to a normal life and work. Our case demonstrates that an aggressive intensive inpatient rehabilitation program combined with stereotactic surgery and effective antituberculosis therapy play an important role in improving the outcome for patients with tuberculous brain abscess, Gerstmann's syndrome, and right-sided apraxia.Keywords: tuberculous brain abscess, Gerstmann's syndrome, rehabilitation

  10. In combination with cisplatin to increase durg sensitivity of temozolomide-resistant glioblastoma multiforme cells%联合顺铂提高对替莫唑胺耐药的多形性胶质母细胞瘤细胞药物敏感性的研究

    Institute of Scientific and Technical Information of China (English)

    李晶波; 史恩红; 董裕翠; 金华; 任欢

    2013-01-01

    目的 探讨多形性胶质母细胞瘤(glioblastoma multiforme,GBM)细胞中O6甲基鸟嘌呤DNA甲基转移酶(O6 methylguanine-DNA-methyltransferase,MGMT)的甲基化状态在替莫唑胺(temozolomide,TMZ)耐药机制中的作用,并检测TMZ与周期非特异性化疗药顺铂(cisplatin,CDDP)联合应用对GBM细胞的增殖抑制效应.方法 将胶质瘤细胞系接种于DMEM培养基(含10%胎牛血清),MTT检测细胞增殖,甲基化特异性PCR(methylation specific polymerase chain reaction,MS-PCR)检测MGMT甲基化状态,Hoechst33342/PI检测凋亡,Chou-Talalay软件分析联合用药的机制.结果 U87MG细胞不具有MG-MT活性,无MGMT蛋白表达;T98G细胞具有MGMT活性,有MGMT蛋白表达;有MGMT活性的T98G细胞抵抗TMZ诱导的凋亡;MGMT抑制剂O6-BG提高了T98G细胞对TMZ敏感性;TMZ与CDDP联合用药效果在T98G细胞中更明显.结论 无MGMT活性的U87MG细胞对TMZ更敏感;有MGMT活性的T98G细胞对TMZ和CDDP的联合化疗更敏感.%Objective To investigate O6 methylguanine-DNA-methyltransferase(MGMT) meth-ylation status mediated temozolomide(TMZ) resistant and evaluate the anti-proliferation effect of TMZ in combination with cell cycle non-specific agent cisplatin (CDDP). Methods Glioblastoma multiforme to be inoculated in DMEM ( 10% fetal bovine serum). MTT assay was used to determine cell proliferation, methylation-specific polymerase chain reaction ( MS-PCR) was applied to detect the methylation status of MGMT gene, Hoechst 33342/PI fluorescent staining was employed to detect the apoptosis, and mechanism of combine medication was evaluated by Chou-Talalay method. Results MGMT was methylated in U87MG which not expressing MGMT protein while incompletely methylated in T98G which expressing MGMT protein. T98G was less sensitive to apoptosis induction following TMZ treatment, while 0 -BG improved the sensitivity of T98G cells to TMZ, and Chou-Talalay analysis showed that TMZ combination with CDDP was more

  11. No gynecologist in town: the gynecological care of women in rural Taiwan

    Directory of Open Access Journals (Sweden)

    Lai LJ

    2015-07-01

    Full Text Available Li-Jung Lai,1 Chia-Lin Chou,2 H Irene Su,3 Tzeng-Ji Chen,1,4 Li-Fang Chou,5 Yueh-Ching Chou,2,6,7 Shinn-Jang Hwang,1,8 Hann-Chin Yu9,10 1Department of Family Medicine, 2Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan; 3Department of Reproductive Medicine, University of California, San Diego, CA, USA; 4Institute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, 5Department of Public Finance, National Chengchi University, 6Department and Institute of Pharmacology, National Yang-Ming University, 7College of Pharmacy, Taipei Medical University, 8Department of Family Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 9Taipei Veterans General Hospital Hsinchu Branch, Hsinchu County, Taiwan; 10Department of Healthcare Management, Yuanpei University, Hsinchu, Taiwan Background: A shortage of gynecologists exists in many countries. Even within an affluent country, gynecological clinics might not be evenly distributed. The purpose of the study was to investigate the disparity in gynecological care between adult women living in towns with and without gynecologists in Taiwan.Methods: Data sources were the cohort datasets of the National Health Insurance Research Database, with claims data of 1 million beneficiaries in 2010. A woman’s residency was operationally inferred from the locations where she had most frequently visited physicians’ clinics or local community hospitals within the year.Results: In Taiwan, 145 (39.4% of 368 towns had no practicing gynecologist. Of 382,167 women with health care use in the datasets, 21,794 (5.7% lived in towns without a gynecologist. The overwhelming majority of these towns lay in sparsely populated, rural areas. During the year, 132,702 women (34.7% had sought medical help for gynecological diseases and 113,698 (29.8% had visited gynecologists for gynecological diseases. Women in towns without a gynecologist were less

  12. The Leipzig Ice Nucleation chamber Comparison (LINC): An overview of ice nucleation measurements observed with four on-line ice nucleation devices

    Science.gov (United States)

    Kohn, Monika; Wex, Heike; Grawe, Sarah; Hartmann, Susan; Hellner, Lisa; Herenz, Paul; Welti, André; Stratmann, Frank; Lohmann, Ulrike; Kanji, Zamin A.

    2016-04-01

    Mixed-phase clouds (MPCs) are found to be the most relevant cloud type leading to precipitation in mid-latitudes. The formation of ice crystals in MPCs is not completely understood. To estimate the effect of aerosol particles on the radiative properties of clouds and to describe ice nucleation in models, the specific properties of aerosol particles acting as ice nucleating particles (INPs) still need to be identified. A number of devices are able to measure INPs in the lab and in the field. However, methods can be very different and need to be tested under controlled conditions with respect to aerosol generation and properties in order to standardize measurement and data analysis approaches for subsequent ambient measurements. Here, we present an overview of the LINC campaign hosted at TROPOS in September 2015. We compare four ice nucleation devices: PINC (Portable Ice Nucleation Chamber, Chou et al., 2011) and SPIN (SPectrometer for Ice Nuclei) are operated in deposition nucleation and condensation freezing mode. LACIS (Leipzig Aerosol Cloud Interaction Simulator, Hartmann et al., 2011) and PIMCA (Portable Immersion Mode Cooling chamber) measure in the immersion freezing mode. PIMCA is used as a vertical extension to PINC and allows activation and droplet growth prior to exposure to the investigated ice nucleation temperature. Size-resolved measurements of multiple aerosol types were performed including pure mineral dust (K-feldspar, kaolinite) and biological particles (Birch pollen washing waters) as well as some of them after treatment with sulfuric or nitric acid prior to experiments. LACIS and PIMCA-PINC operated in the immersion freezing mode showed very good agreement in the measured frozen fraction (FF). For the comparison between PINC and SPIN, which were scanning relative humidity from below to above water vapor saturation, an agreement was found for the obtained INP concentration. However, some differences were observed, which may result from ice

  13. A PRELIMINARY ANNOTATED CHECKLIST OF THE PAPILIONIDAE OF LAOS WITH NOTES ON TAXONOMY, PHENOLOGY, DISTRIBUTION AND VARIATION (Lepidoptera, Papilionoidea

    Directory of Open Access Journals (Sweden)

    A.M. Cotton

    2006-10-01

    Full Text Available 63 Papilionid taxa of Laos are reported representing 60 biological species. Of these, the occurrence of Papilio elephenor is unproven, and that of Papilio krishna is refuted, leaving 58 species confirmed for Laos. Notes on their taxonomy, distribution, phenology and variation are given. The following synonymies or changes of status are herewith listed:Graphium antiphates itamputi is regarded as a separate subspecies from pompilius stat. rev.Papilio tamerlanus timur Ney, 1911 is a synonym of Papilio alebion mullah Alphéraky, 1897, syn. nov. The following combinations are therefore proposed for the collective species: Graphium mullah mullah (Alphéraky, 1897 comb. nov. applies to the Sichuan population; Graphium mullah chungianus (Murayama, 1961 comb. nov., for the Taiwanese subspecies; and Graphium mullah kooichii (Morita, 1996 comb. nov. for the Lao subspecies.The true type of Papilio arycles sphinx Fruhstorfer, 1899 is identified, and arycleoides Fruhstorfer, 1902 placed in synonymy, syn. nov.Teinopalpus imperialis bhumipoli Nakano & Sukkit, 1985, T. i. gerritesi Nakano, 1995, T. i. gillesi Turlin, 1991, and T. i. hakkaorum Schäffler 2004 are shown to be synonyms of Teinopalpus imperialis imperatrix de Nicéville, 1899, syn. nov.Atrophaneura varuna liziensis Zhao, 1997 is synonymized with A. varuna astorion (Westwood, 1842 syn. nov.The names elegans Chou et al., 2000, pulcher Chou et al., 2000 and longimacula Wang & Niu, 2002 are sunk as synonyms of Papilio bianor bianor syn. nov.Papilio bianor significans Fruhstorfer, 1902 is regarded as a valid subspecies (stat. rev. and the ranges of Papilio bianor gladiator Fruhstorfer, [1902] and ganesa Doubleday, 1842 are clarified.Papilio noblei de Nicéville, [1889] is shown to be monotypic, and haynei Tytler, 1926 is sunk as a synonym syn. nov.Papilio hipponous siamensis Godfrey, 1916 is synonymized with pitmani Elwes & de Nicéville, [1887] syn. nov.The taxon imitata Monastyrskii & Devyatkin, 2003

  14. WorldSID Dummy Head-Neck Biofidelity Response.

    Science.gov (United States)

    Been, Bernard; Philippens, Mat; de Lange, Ronald; van Ratingen, Michiel

    2004-11-01

    Accident studies indicate that serious neck injuries are generally infrequent in side crashes. However, given the rapid changes in side impact protection technology, such as side airbags and curtain systems, the nature of head-neck interactions is likely to change. Consequently, the newest generation of anthropomorphic test devices for side impact should provide realistic prediction of the head-neck kinematics and include meaningful measurements related to risk of head and neck injury. The WorldSID dummy has been assessed against a set of five test conditions that have been used to define biofidelity impact response targets. Three of the five test conditions are recommended by ISO TR9790 (ISO 1997), the NBDL 7.2 G, 6.9 m/s lateral sled impact reported by Ewing et al. (1977) and Wismans et al. (1986) , the Patrick and Chou lateral, 6.7 G 5.8 m/s (1976) and Tarriere lateral 12.2 g, 6,1 m/s sled impact (ISO 1997). Due to its expected loading environment, the dummy neck performance has also been evaluated for neck bending in frontal flexion and extension (Mertz and Patrick, 1971). The 5th test condition is the NBDL 45 degrees frontal-oblique sled test (Wismans 1986, Philippens 2004). The latter and two of the ISO TR9790 test conditions form the basis of the draft IHRA requirements for evaluating side impact dummy biomechanical responses. The paper reports on the findings of the assessment of the WorldSID pre-production dummy. The Mertz and Patrick OC moment-head angle corridor is used as supplemental requirement for frontal flexion-extension. The biofidelity requirements contain both kinematic and dynamic response targets. The neck has a good performance for NBDL lateral and Tarriere requirements, and the Mertz OC moment-flexion angle. The performance for the Patrick and Chou, the NBDL oblique test conditions and the Mertz OC moment extension angle are fair to marginal. The repeatability performance of the dummy was found to be good for all lateral and most oblique

  15. Effects of electroacupuncture on recent stroke inpatients with incomplete bladder emptying: a preliminary study

    Directory of Open Access Journals (Sweden)

    Yu KW

    2012-11-01

    Full Text Available Kuo-Wei Yu,1,* Chien-Lin Lin,1,2 Chun-Chuang Hung,3 Eric Chieh-Lung Chou,4 Yueh-Ling Hsieh,5 Te-Mao Li,2,3,* Li-Wei Chou1,2,61Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 2School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 3Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan; 4Department of Urology, China Medical University Hospital, Taichung, Taiwan; 5Department of Physical Therapy, China Medical University, Taichung, Taiwan; 6Acupuncture Research Center, China Medical University, Taichung, Taiwan*These authors contributed equally to this workBackground: Incomplete bladder emptying (IBE is defined as having a postvoid residual (PVR urine volume greater than 100 mL for 2 consecutive days. IBE is common in stroke patients and could necessitate indwelling or intermittent catheterization. The condition is correlated with urinary tract infections, which could impede rehabilitation progress and increase medical costs. Treatment for patients with IBE includes bladder retraining, biofeedback, medication, and botulinum toxin injection, but none of these interventions are completely effective.Methods: All patients with acute stroke who were admitted to the rehabilitation ward between August 2010 and April 2011 were included in the study and their PVR urine volume was checked. Electroacupuncture (EA; 1 Hz, 15 minutes was performed on the acupoints Sanyinjiao (SP6, Ciliao (BL32, and Pangguangshu (BL28 of stroke patients with IBE for a total of ten treatments (five times a week for 2 weeks. Bladder diaries, which included the spontaneous voiding and PVR urine volumes, were recorded during the course of treatment.Results: The presence of IBE was not related to sex, history of diabetes mellitus, stroke type (hemorrhagic or ischemic, or stroke location (P > 0.05. Among the 49 patients in the study, nine (18% had IBE

  16. 应用生物信息学分析大米过敏原RAG1的B细胞表位(英文)%Bioinformatics Analysis on B cell Epitopes of Rice Allergen RAG1

    Institute of Scientific and Technical Information of China (English)

    李燕芳; 何颖; 邹泽红

    2012-01-01

    [Objective] To predict the secondary structure and B cell epitopes of the rice major allergen RAG1. [Method] The amino acid sequence of rice allergen RAG1 was acquired from Expasy protein database. The secondary structure of RAG1 was predicted by DNAStar Protean software with Gamier-Robson program, Chou-Fasman program and Karplus-Schulz program; the B cell epitopes of RAG1 was predicted with the Kyte Doolittle hydrophilic program, Emini surface accessibility program and Jameson-Wolf antigenic index program. [Result] The predictions on secondary structure and B cell epitopes showed that the regions of 33-44, 119-129, 155-163 were the dominant B cell epitopes. [Conclusion] This study predicted the potential dominant B cell epitopes in rice allergen RAG1 by comprehensive use of multi-methods and multi-parameters, and provided a theoretical basis for further researches on identification, antigen modification and epitope vaccine design of RAG1 B cell epitopes.%[目的]预测大米主要过敏原RAG1的二级结构及B细胞表位。[方法]从Expasy蛋白质数据库中获得编码大米过敏原RAG1的氨基酸序列并以此氨基酸序列为基础,通过DNAStarProtean软件,采用Gamier-Robson方案、Chou-Fasman方案和Karplus-Schulz方案预测RAG1的二级结构,用Kyte-Doolittle亲水性方案、Emini表面可及性方案、Jameson-Wolf抗原性指数方案综合预测RAG1的B细胞表位。[结果]对大米过敏原RAG1的二级结构和B细胞表位预测的结果表明,第33~44、119~129、155~163区段可能是B细胞的优势表位。[结论]本研究综合应用多方法多参数预测大米过敏原RAG1潜在的B细胞优势表位,为RAG1B细胞表位的进一步鉴定及其抗原性改造、表位疫苗设计等研究提供了理论依据。

  17. Bioinformatics Analysis on B Cell Epitopes of Rice Allergen RAG1%应用生物信息学分析大米过敏原RAG1的B细胞表位

    Institute of Scientific and Technical Information of China (English)

    李燕芳; 何颖; 邹泽红

    2012-01-01

    [目的]预测大米主要过敏原RAG1的二级结构及B细胞表位.[方法]从Expasy蛋白质数据库中获得编码大米过敏原RAG1的氨基酸序列并以此氨基酸序列为基础,通过DNAStar Protean软件,采用Gamier-Robson方案、Chou-Fasman方案和Karplus-Schulz方案预测RAG1的二级结构,用Kyte-Doolittle亲水性方案、Emini表面可及性方案、Jameson-Wolf抗原性指数方案综合预测RAG1的B细胞表位.[结果]对大米过敏原RAG1的二级结构和B细胞表住预测的结果表明,第33 ~44、119 ~129、155~163区段可能是B细胞的优势表位.[结论]该研究综合应用多方法多参数预测大米过敏原RAG1潜在的B细胞优势表位,为RAG1 B细胞表位的进一步鉴定及其抗原性改造、表位疫苗设计等研究提供了理论依据.%[Objective] To predict secondary structure and B cell epilopes of the rice major allergen RAG1. [ Method ] The amino acid sequence of rice allergen RAG1 was acquired from Expasy protein database. The secondary structure of RAG1 was predicted by DNAStar Protean software with Gamier-Robson program, Chou-Fasman program and Karplus-Schulz program; the B cell epitopes of RAG1 was predicted with the Kyte-Doolittle hydrophilic program, Emini surface accessibility program and Jameson-Wolf antigenic index program. [ Result] The predictions on secondary structure and B cell epitopes showed that the regions of 33 -44, 119 - 129, 155 - 163 were the dominant B cell epitopes. [Conclusion] This study predicted the potential dominant B cell epitopes in rice allergen RAG1 by comprehensive use of multi-methods and multi-parameters, and provided a theoretical basis for further researches on identification, antigen modification and epitope vaccine design of RAG1 B cell epitopes.

  18. Influence of the geothermal fluid rheology in the large scale hydro-thermal circulation in Soultz-sous-Forêts reservoir.

    Science.gov (United States)

    Vallier, Bérénice; Magnenet, Vincent; Fond, Christophe; Schmittbuhl, Jean

    2017-04-01

    Many numerical models have been developed in deep geothermal reservoir engineering to interpret field measurements of the natural hydro-thermal circulations or to predict exploitation scenarios. They typically aim at analyzing the Thermo-Hydro-Mechanical and Chemical (THMC) coupling including complex rheologies of the rock matrix like thermo-poro-elasticity. Few approaches address in details the role of the fluid rheology and more specifically the non-linear sensitivity of the brine rheology with temperature and pressure. Here we use the finite element Code_Aster to solve the balance equations of a 2D THM model of the Soultz-sous-Forêts reservoir. The brine properties are assumed to depend on the fluid pressure and the temperature as in Magnenet et al. (2014). A sensitive parameter is the thermal dilatation of the brine that is assumed to depend quadratically with temperature as proposed by the experimental measurements of Rowe and Chou (1970). The rock matrix is homogenized at the scale of the equation resolution assuming to have a representative elementary volume of the fractured medium smaller than the mesh size. We still chose four main geological units to adjust the rock physic parameters at large scale: thermal conductivity, permeability, radioactive source production rate, elastic and Biot parameters. We obtain a three layer solution with a large hydro-thermal convection below the cover-basement transition. Interestingly, the geothermal gradient in the sedimentary layer is controlled by the radioactive production rate in the upper altered granite. The second part of the study deals with an inversion approach of the homogenized solid and fluid parameters at large scale using our direct THM model. The goal is to compare the large scale inverted estimates of the rock and brine properties with direct laboratory measurements on cores and discuss their upscaling in the context of a fractured network hydraulically active. Magnenet V., Fond C., Genter A. and

  19. Borehole data package for wells 299-W22-48, 299-W22-49, and 299-W22-50 at single-shell tank waste management Area S-SX

    Energy Technology Data Exchange (ETDEWEB)

    DG Horton; VG Johnson

    2000-05-18

    Three new Resource Conservation and Recovery Act (RCRA) groundwater monitoring wells were installed at the single-shell tank farm Waste Management Area (WMA) S-SX in October 1999 through February 2000 in fulfillment of Tri-Party Agreement (Ecology 1996) milestone M-24-41. The wells are 299-W22-48, 299-W22-49, and 299-W22-50. Well 299-W22-48 is located east of the southeast corner of 241-S tank farm and is a new downgradient well in the monitoring network. Well 299-W22-49 is located on the east side of the 241-SX tank farm, adjacent to well 299-W22-39, which it replaces in the monitoring network. Well 299-W22-50 is located at the southeast corner of the 241-SX tank farm and is a replacement for downgradient monitoring well 299-W22-46, which is going dry. The original assessment monitoring plan for WMA S-SX was issued in 1996 (Caggiano 1996). That plan was updated for the continued assessment at WMA S-SX in 1999 (Johnson and Chou 1999). The updated plan provides justification for the new wells. The new wells were constructed to the specifications and requirements described in Washington Administrative Code (WAC) 173-160 and WAC 173-303, the updated assessment plan for WMA S-SX (Johnson and Chou 1999), and the description of work for well drilling and construction. This document compiles information on the drilling and construction, well development, pump installation, and sediment and groundwater sampling applicable to the installation of wells 299-W22-48, 299-W22-49 and 299-W22-50. Appendix A contains the Well Summary Sheets (as-built diagrams), the Well Construction Summary Reports, and the geologist's logs. Appendix B contains results of laboratory analyses of the physical properties of sediment samples obtained during drilling. Appendix C contains borehole geophysical logs, and Appendix D contains the analytical results from groundwater samples obtained during well drilling and construction.

  20. Immersion freezing in concentrated solution droplets for a variety of ice nucleating particles

    Science.gov (United States)

    Wex, Heike; Kohn, Monika; Grawe, Sarah; Hartmann, Susan; Hellner, Lisa; Herenz, Paul; Welti, Andre; Lohmann, Ulrike; Kanji, Zamin; Stratmann, Frank

    2016-04-01

    The measurement campaign LINC (Leipzig Ice Nucleation counter Comparison) was conducted in September 2015, during which ice nucleation measurements as obtained with the following instruments were compared: - LACIS (Leipzig Aerosol Cloud Interaction Simulator, see e.g. Wex et al., 2014) - PIMCA-PINC (Portable Immersion Mode Cooling Chamber together with PINC) - PINC (Portable Ice Nucleation Chamber, Chou et al., 2011) - SPIN (SPectrometer for Ice Nuclei, Droplet Measurement Technologies) While LACIS and PIMCA-PINC measured immersion freezing, PINC and SPIN varied the super-saturation during the measurements and collected data also for relative humidities below 100% RHw. A suite of different types of ice nucleating particles were examined, where particles were generated from suspensions, subsequently dried and size selected. For the following samples, data for all four instruments are available: K-feldspar, K-feldspar treated with nitric acid, Fluka-kaolinite and birch pollen. Immersion freezing measurements by LACIS and PIMCA-PINC were in excellent agreement. Respective parameterizations from these measurement were used to model the ice nucleation behavior below water vapor saturation, assuming that the process can be described as immersion freezing in concentrated solutions. This is equivalent to simply including a concentration dependent freezing point depression in the immersion freezing parameterization, as introduced for coated kaolinite particles in Wex et al. (2014). Overall, measurements performed below water vapor saturation were reproduced by the model, and it will be discussed in detail, why deviations were observed in some cases. Acknowledgement: Part of this work was funded by the DFG Research Unit FOR 1525 INUIT, grant WE 4722/1-2. Literature: Chou, C., O. Stetzer, E. Weingartner, Z. Juranyi, Z. A. Kanji, and U. Lohmann (2011), Ice nuclei properties within a Saharan dust event at the Jungfraujoch in the Swiss Alps, Atmos. Chem. Phys., 11(10), 4725

  1. Miscanthus plants used as an alternative biofuel material. The basic studies on ecology and molecular evolution

    Energy Technology Data Exchange (ETDEWEB)

    Chou, Chang-Hung [Graduate Institute of Ecology and Evolutionary Biology, College of Life Sciences, China Medical University, Taichung 404 (China)

    2009-08-15

    Miscanthus Anderss, widely distributed in Asia and Pacific Islands, possesses 20 species. Of which 8 species and 1 variety were recorded in Chinese Mainland; 6 species and 1 variety found in Japan; 5 species and 3 varieties distributed in Taiwan; 3 species documented in the Philippines; and rest of species have been recorded in Jawa, eastern Himalaya, and Sikkim. The plant is a C{sub 4} perennial grass with high productivity of biomass. In the 19th and early 20th centuries in Taiwan, Miscanthus was a very important crop used for forage grass, clothing, and shelter, etc. The relatively high germination, and high yield of biomass made the plant available for people of Taiwan including aboriginal. The taxonomic study of Miscanthus plants was much done by several scientists, and its ecological study has been only taken by the present author since 1972. Chou and his associates paid a great attention to elucidate the mechanism of dominance of Miscanthus vegetation and found that allelopathy plays an important role. In addition, the population biology of Miscanthus taxa by using polyacrylamide gel electrophoreses technique to examine the patterns of peroxidase and esterase among populations (over 100) of Miscanthus in Taiwan were conducted. They also elucidated the phylogenetic relationship among species and varieties in Taiwan. Chou and Ueng proposed an evolutionary trend of Miscanthus species, indicating that the Miscanthus sinensis was assumed to be the origin of Miscanthus Anderss, which evolved to M. sinensis var. formosana, and M. sinensis var. flavidus, and M. sinensis var. transmorrisonensis, and Miscanthus floridulus was thought to be an out group of M. sinensis complex. Moreover, molecular phylogeny was attempted to clarify the population heterogeneity of M. sinensis complex, resulting in a substantial information. It would be available for making hybridization between Miscanthus species and its related species, such as Saccharum (sugar cane) spp. which is a

  2. Prediction of B Cell Epitopes,Synthesis And Development of Indirect ELISA for N Protein of Peste Des Petits Ruminants Virus%小反刍兽疫病毒N蛋白B细胞表位预测、合成及间接ELISA方法的建立

    Institute of Scientific and Technical Information of China (English)

    曾少灵; 李希强; 王红英; 杨俊兴; 花群义; 阮周曦; 唐金明; 廖立珊; 孙洁; 林庆燕; 吕建强; 叶奕优; 祝贺

    2015-01-01

    Based on the amino acid sequence and the analysis results of secondary structures such as α-he-lix,β-sheet and turn regions,etc,the B cell epitopes for N protein of peste des petits ruminants virus were predicted by methods of Gamier-Robson and Chou-Fasman.Four artificial peptides were designed,synthe-sized and used as coating antigens,by which the indirect ELISA of serum antibody test for peste des petits ruminants virus was developed.The comparison test on goat clinical serum samples was carried out.Com-pared with the imported standard competitive ELISA,the sensitivity and specificity of the developed indi-rect ELISA were 96.0% and 96.25%,and the coincidence rate of the two methods was 96.15%.So the developed indirect ELISA method coating with synthetic peptides is suitable for clinical application.%基于氨基酸序列和采用 Gamier-Robson和 Chou-Fasman等多种方法分析的α-螺旋、β-折叠和转角等二级结构结果,预测小反刍兽疫病毒 N 蛋白的 B 细胞抗原表位。设计4段多肽并进行人工合成,作为包被抗原建立小反刍兽疫血清抗体间接 ELISA 检测方法,用于检测小反刍兽疫山羊临床血清样品,以对预测的 B 细胞抗原表位进行验证。结果显示,研制的间接 ELISA 敏感性为96.0%,特异性为96.25%,与进口标准竞争 ELISA 试剂盒的符合率为96.15%。结果表明,研制的间接 ELISA 方法适用于小反刍兽疫临床血清抗体的检测。

  3. A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase.

    Directory of Open Access Journals (Sweden)

    Kenneth W Yip

    Full Text Available Uroporphyrinogen decarboxylase (UROD catalyzes the conversion of uroporphyrinogen to coproporphyrinogen during heme biosynthesis. This enzyme was recently identified as a potential anticancer target; its inhibition leads to an increase in reactive oxygen species, likely mediated by the Fenton reaction, thereby decreasing cancer cell viability and working in cooperation with radiation and/or cisplatin. Because there is no known chemical UROD inhibitor suitable for use in translational studies, we aimed to design, synthesize, and characterize such a compound. Initial in silico-based design and docking analyses identified a potential porphyrin analogue that was subsequently synthesized. This species, a porphodimethene (named PI-16, was found to inhibit UROD in an enzymatic assay (IC50 = 9.9 µM, but did not affect porphobilinogen deaminase (at 62.5 µM, thereby exhibiting specificity. In cellular assays, PI-16 reduced the viability of FaDu and ME-180 cancer cells with half maximal effective concentrations of 22.7 µM and 26.9 µM, respectively, and only minimally affected normal oral epithelial (NOE cells. PI-16 also combined effectively with radiation and cisplatin, with potent synergy being observed in the case of cisplatin in FaDu cells (Chou-Talalay combination index <1. This work presents the first known synthetic UROD inhibitor, and sets the foundation for the design, synthesis, and characterization of higher affinity and more effective UROD inhibitors.

  4. Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus.

    Science.gov (United States)

    Khurana, Ekta; Devane, Russell H; Dal Peraro, Matteo; Klein, Michael L

    2011-02-01

    The M2 protein of influenza A virus performs the crucial function of transporting protons to the interior of virions enclosed in the endosome. Adamantane drugs, amantadine (AMN) and rimantidine (RMN), block the proton conduction in some strains, and have been used for the treatment and prophylaxis of influenza A infections. The structures of the transmembrane (TM) region of M2 that have been solved in micelles using NMR (residues 23-60) (Schnell and Chou, 2008) and by X-ray crystallography (residues 22-46) (Stouffer et al., 2008) suggest different drug binding sites: external and internal for RMN and AMN, respectively. We have used molecular dynamics (MD) simulations to investigate the nature of the binding site and binding mode of adamantane drugs on the membrane-bound tetrameric M2-TM peptide bundles using as initial conformations the low-pH AMN-bound crystal structure, a high-pH model derived from the drug-free crystal structure, and the high-pH NMR structure. The MD simulations indicate that under both low- and high-pH conditions, AMN is stable inside the tetrameric bundle, spanning the region between residues Val27 to Gly34. At low pH the polar group of AMN is oriented toward the His37 gate, while under high-pH conditions its orientation exhibits large fluctuations. The present MD simulations also suggest that AMN and RMN molecules do not show strong affinity to the external binding sites.

  5. Wild jujube polysaccharides protect against experimental inflammatory bowel disease by enabling enhanced intestinal barrier function.

    Science.gov (United States)

    Yue, Yuan; Wu, Shuangchan; Li, Zhike; Li, Jian; Li, Xiaofei; Xiang, Jin; Ding, Hong

    2015-08-01

    Dietary polysaccharides provide various beneficial effects for our health. We investigated the protective effects of wild jujube (Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou) sarcocarp polysaccharides (WJPs) against experimental inflammatory bowel disease (IBD) by enabling enhanced intestinal barrier function. Colitis was induced in rats by the intrarectal administration of TNBS. We found that WJPs markedly ameliorated the colitis severity, including less weight loss, decreased disease activity index scores, and improved mucosal damage in colitis rats. Moreover, WJPs suppressed the inflammatory response via attenuation of TNF-α, IL-1β, IL-6 and MPO activity in colitis rats. And then, to determine the effect of WJPs on the intestinal barrier, we measured the effect of WJPs on the transepithelial electrical resistance (TER) and FITC-conjugated dextran permeability in Caco-2 cell stimulation with TNF-α. We further demonstrated that the alleviation of WJPs to colon injury was associated with barrier function by assembly of tight junction proteins. Moreover, the effect of WJPs on TER was eliminated by the specific inhibitor of AMPK. AMPK activity was also up-regulated by WJPs in Caco-2 cell stimulation with TNF-α and in colitis rats. This study demonstrates that WJPs protect against IBD by enabling enhanced intestinal barrier function involving the activation of AMPK.

  6. Chronic shoulder pain referred from thymic carcinoma: a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Dee SW

    2012-09-01

    Full Text Available Shu-Wei Dee,1 Mu-Jung Kao,2,3 Chang-Zern Hong,4 Li-Wei Chou,1,5 Henry L Lew6,71Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, 2Department of Physical Medicine and Rehabilitation, Yangming Branch, Taipei City Hospital, Taipei, 3Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, 4Department of Physical Therapy, Hungkuang University, Taichung, 5School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 6Defense and Veterans Brain Injury Center, Virginia Commonwealth University, Richmond, Virginia, 7University of Hawaii at Manoa, John A Burns School of Medicine, Honolulu, Hawaii, USAAbstract: We report a case of thymic carcinoma presenting as unilateral shoulder pain for 13 months. Before an accurate diagnosis was made, the patient received conservative treatment, cervical discectomies, and myofascial trigger point injection, none of which relieved his pain. When thymic carcinoma was eventually diagnosed, he received total resection of the tumor and the shoulder pain subsided completely. Thymic carcinoma is a rare carcinoma, and our review of the literature did not show shoulder pain as its initial presentation except for one case report. The purpose of this report is to document our clinical experience so that other physiatrists can include thymic carcinoma in their differential diagnosis of shoulder pain.Keywords: referred pain, shoulder pain, thymic carcinoma

  7. Imaging Prostate Cancer Invasion with Multi-Nuclear Magnetic Resonance Methods: The Metabolic Boyden Chamber

    Directory of Open Access Journals (Sweden)

    Ulrich Pilatus

    2000-05-01

    Full Text Available The physiological milieu within solid tumors can influence invasion and metastasis. To determine the impact of the physiological environment and cellular metabolism on cancer cell invasion, it is necessary to measure invasion during well-controlled modulation of the physiological environment. Recently, we demonstrated that magnetic resonance imaging can be used to monitor cancer cell invasion into a Matrigel layer [Artemov D, Pilatus U, Chou S, Mori N, Nelson JB, and Bhujwalla ZM. (1999. Dynamics of prostate cancer cell invasion studied in vitro by NMR microscopy. Mag Res Med 42, 277–282.]. Here we have developed an invasion assay (“Metabolic Boyden Chamber” that combines this capability with the properties of our isolated cell perfusion system. Long-term experiments can be performed to determine invasion as well as cellular metabolism under controlled environmental conditions. To characterize the assay, we performed experiments with prostate cancer cell lines preselected for different invasive characteristics. The results showed invasion into, and degradation of the Matrigel layer, by the highly invasive/metastatic line (MatLyLu, whereas no significant changes were observed for the less invasive/metastatic cell line (DU-145. With this assay, invasion and metabolism was measured dynamically, together with oxygen tensions within the cellular environment and within the Matrigel layer. Such a system can be used to identify physiological and metabolic characteristics that promote invasion, and evaluate therapeutic interventions to inhibit invasion.

  8. CONDENSATION OF 1,2-DIAMINES AND CARBOXYLICACIDS UNDER MICROWAVE IRRADIATION

    Institute of Scientific and Technical Information of China (English)

    MENG; Qing-hua(

    2001-01-01

    [1]Puntambekar N V, Jablokow A G, Sommer H J. Unified review of 3D model generation for reverse engineering[J]. Computer Integrated Manufacturing System,1994,7(4):259~268.[2]Chikofsky E J. Reverse engineering and design recovery: a taxonomy[J]. IEEE Software,1990,6(3):13~17.[3]Chou Hon-yue. Application of reverse engineering in die and mold manufacturing[A]. 3rd Int Conf on Mould & Die Technique in Asia[C]. Taibei, China,1995.753~764.[4]Dipl-Ing Thomas Haller. Rapid mould and die making using reverse engineering and rapid prototyping[A]. 3rd Int Conf on Mould & Die Technique in Asia[C]. Taibei, China,1995.739~752.[5]Abella R J, Daschbach J M. Reverse engineering industrial applications[J]. Computers Ind Engng,1994,26(2):381~385.[6]Chen Y D, Tang X J. Automatic digitization of freeform curves by coordinate measuring machines[J]. ASME PED,1992,62:113~125.[7]Antonie van Rensburg. Implementing IDEF techniques as simulation modeling specifications[J]. Computers Ind Engng,1994,29(1-4):467~571.[8]Eastma C M, Fereshetian N. Informaiton models for use in product design: a comparison[J]. Computer-Aided Design.1994,26(7):551~572.

  9. FORMING FREEFORM SURFACE SHEET METAL USINGINTEGRATED REVERSE ENGINEERING TECHNOLOGY

    Institute of Scientific and Technical Information of China (English)

    XING; Yuan(

    2001-01-01

    [1]Puntambekar N V, Jablokow A G, Sommer H J. Unified review of 3D model generation for reverse engineering[J]. Computer Integrated Manufacturing System,1994,7(4):259~268.[2]Chikofsky E J. Reverse engineering and design recovery: a taxonomy[J]. IEEE Software,1990,6(3):13~17.[3]Chou Hon-yue. Application of reverse engineering in die and mold manufacturing[A]. 3rd Int Conf on Mould & Die Technique in Asia[C]. Taibei, China,1995.753~764.[4]Dipl-Ing Thomas Haller. Rapid mould and die making using reverse engineering and rapid prototyping[A]. 3rd Int Conf on Mould & Die Technique in Asia[C]. Taibei, China,1995.739~752.[5]Abella R J, Daschbach J M. Reverse engineering industrial applications[J]. Computers Ind Engng,1994,26(2):381~385.[6]Chen Y D, Tang X J. Automatic digitization of freeform curves by coordinate measuring machines[J]. ASME PED,1992,62:113~125.[7]Antonie van Rensburg. Implementing IDEF techniques as simulation modeling specifications[J]. Computers Ind Engng,1994,29(1-4):467~571.[8]Eastma C M, Fereshetian N. Informaiton models for use in product design: a comparison[J]. Computer-Aided Design.1994,26(7):551~572.

  10. DYNAMIC LABELING BASED FPGA DELAY OPTIMIZATION ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    L; Zong-wei(

    2001-01-01

    [1]Puntambekar N V, Jablokow A G, Sommer H J. Unified review of 3D model generation for reverse engineering[J]. Computer Integrated Manufacturing System,1994,7(4):259~268.[2]Chikofsky E J. Reverse engineering and design recovery: a taxonomy[J]. IEEE Software,1990,6(3):13~17.[3]Chou Hon-yue. Application of reverse engineering in die and mold manufacturing[A]. 3rd Int Conf on Mould & Die Technique in Asia[C]. Taibei, China,1995.753~764.[4]Dipl-Ing Thomas Haller. Rapid mould and die making using reverse engineering and rapid prototyping[A]. 3rd Int Conf on Mould & Die Technique in Asia[C]. Taibei, China,1995.739~752.[5]Abella R J, Daschbach J M. Reverse engineering industrial applications[J]. Computers Ind Engng,1994,26(2):381~385.[6]Chen Y D, Tang X J. Automatic digitization of freeform curves by coordinate measuring machines[J]. ASME PED,1992,62:113~125.[7]Antonie van Rensburg. Implementing IDEF techniques as simulation modeling specifications[J]. Computers Ind Engng,1994,29(1-4):467~571.[8]Eastma C M, Fereshetian N. Informaiton models for use in product design: a comparison[J]. Computer-Aided Design.1994,26(7):551~572.

  11. Individual and combined effects of Aflatoxin B1, Deoxynivalenol and Zearalenone on HepG2 and RAW 264.7 cell lines.

    Science.gov (United States)

    Zhou, Hongyuan; George, Saji; Hay, Crystal; Lee, Joel; Qian, He; Sun, Xiulan

    2017-05-01

    To understand the combinatorial toxicity of mycotoxins, we measured the effects of individual, binary and tertiary combinations of Aflatoxin B1 (AFB1), Deoxynivalenol (DON) and Zearalenone (ZEN) on the cell viability and cellular perturbations of HepG2 and RAW 264.7 cells. The nature of mycotoxins interactions was assessed using mathematical modeling (Chou-Talalay). Mechanisms of cytotoxicity were studied using high content screening (HCS) that probed cytotoxicity responses, such as changes in intracellular reactive oxygen species (ROS), mitochondrial membrane potential (MMP), intracellular calcium ([Ca(2+)]i) flux, and cell membrane damage. Our results showed that individual cytotoxicity of mycotoxins in a decreasing order was DON>AFB1>ZEN. Varying combinations of mycotoxins at differing concentrations showed different types of interactions. Most of the mixtures showed increasing toxic effects-synergism and/or addition while antagonistic effects were observed with combination of AFB1+ZEN. Generally, combination of mycotoxins showed significantly increased intracellular ROS production and [Ca(2+)]i flux, and decreased MMP in both cell lines, showing that the synergistic and additive effects of mycotoxin combination originate from perturbations of multiple cellular functions. Additionally, this study demonstrated the applicability of HCS for gaining mechanistic understanding on the toxicity of individual as well as combinatorial mycotoxins, and also provided scientific bases for formulating regulatory policies. Copyright © 2017. Published by Elsevier Ltd.

  12. Summary of the Research on Wang Chuansong’ s Performing Arts%王传淞表演艺术研究述略

    Institute of Scientific and Technical Information of China (English)

    周立波

    2014-01-01

    The contribution of Wang Chuansong to kunqu opera, especially the stage performance of clown and fu-chou role plays a very important role for the development and inheritance of kunqu opera. The research on Wang Chuansong over half a century covers a wide range of areas, including the research on biographical information, stage performance and his school and origin of kunqu opera.%王传淞对昆剧艺术的贡献,特别是对昆剧丑行和副行舞台表演的贡献,为昆剧艺术的发展和传承起到了十分重要的作用。综观半个多世纪对王传淞的研究,所涉猎的领域十分广泛,既有对其生平资料的研究,也有对其舞台表演的研究,还有对其昆剧家门的研究。

  13. Analyse critique et dimensionnelle du concept de santéisation

    Directory of Open Access Journals (Sweden)

    Hélène Poliquin

    2015-01-01

    Full Text Available Devant les avancées biomédicales ainsi que l’accroissement des coûts en santé, les individus sont incités à redouter et prévenir les maladies en modifiant leurs comportements. De plus, la santé élevée au rang des vertus ou « la santéisation » s’inscrit au cœur des valeurs modernes néolibérales que sont l’autonomie, la responsabilisation et la performance. Dorénavant, la santé et les comportements de santé constituent des moyens privilégiés d’aspirer au bonheur, au bien-être et à l’accomplissement de soi d’autant plus que l’individu jouit d’un statut socioéconomique élevé. Néanmoins, la santéisation peut aussi contribuer à la stigmatisation et l’exclusion sociale en plus de renforcer le sentiment chez certains d’avoir échoué à être des citoyens responsables. Ce texte présente une analyse critique et dimensionnelle du concept de santéisation qui s’appuie, sur cadre théorique composé entre autres, de travaux de Foucault sur le gouvernement des vivants et de Taylor sur l’individu moderne.

  14. Haar-Wavelet-Based Just Noticeable Distortion Model for Transparent Watermark

    Directory of Open Access Journals (Sweden)

    Lu-Ting Ko

    2012-01-01

    Full Text Available Watermark transparency is required mainly for copyright protection. Based on the characteristics of human visual system, the just noticeable distortion (JND can be used to verify the transparency requirement. More specifically, any watermarks whose intensities are less than the JND values of an image can be added without degrading the visual quality. It takes extensive experimentations for an appropriate JND model. Motivated by the texture masking effect and the spatial masking effect, which are key factors of JND, Chou and Li (1995 proposed the well-known full-band JND model for the transparent watermark applications. In this paper, we propose a novel JND model based on discrete wavelet transform. Experimental results show that the performance of the proposed JND model is comparable to that of the full-band JND model. However, it has the advantage of saving a lot of computation time; the speed is about 6 times faster than that of the full-band JND model.

  15. Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation.

    Science.gov (United States)

    Brahmbhatt, Meera; Gundala, Sushma R; Asif, Ghazia; Shamsi, Shahab A; Aneja, Ritu

    2013-01-01

    Dietary phytochemicals offer nontoxic therapeutic management as well as chemopreventive intervention for slow-growing prostate cancers. However, the limited success of several single-agent clinical trials suggest a paradigm shift that the health benefits of fruits and vegetables are not ascribable to individual phytochemicals, rather may be ascribed to synergistic interactions among them. We recently reported growth-inhibiting and apoptosis-inducing properties of ginger extract (GE) in in vitro and in vivo prostate cancer models. Nevertheless, the nature of interactions among the constituent ginger biophenolics, viz. 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogoal, remains elusive. Here we show antiproliferative efficacy of the most-active GE biophenolics as single-agents and in binary combinations, and investigate the nature of their interactions using the Chou-Talalay combination index (CI) method. Our data demonstrate that binary combinations of ginger phytochemicals synergistically inhibit proliferation of PC-3 cells with CI values ranging from 0.03 to 0.88. To appreciate synergy among phytochemicals present in GE, the natural abundance of ginger biophenolics was quantitated using LC-UV/MS. Interestingly, combining GE with its constituents (in particular, 6-gingerol) resulted in significant augmentation of GE's antiproliferative activity. These data generate compelling grounds for further preclinical evaluation of GE alone and in combination with individual ginger biophenols for prostate cancer management.

  16. BRAF mutational analysis in ovarian tumors: recent perspectives

    Directory of Open Access Journals (Sweden)

    Wong KK

    2015-09-01

    Full Text Available Kwong-Kwok Wong,1 Ching-Chou Tsai,2 David M Gershenson11Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of ChinaAbstract: BRAF mutations are rare in ovarian cancer and mainly occur in indolent serous borderline tumors (SBTs, also known as serous tumors of low malignant potential or atypical proliferative serous tumors. The reported percentage of BRAF mutations in SBTs varies from 23% to 71%. Although a high percentage of stage II–IV SBTs with noninvasive implants have progressed to invasive low-grade serous carcinomas when patients were observed for 5 years or longer, BRAF mutations are rare in low-grade serous carcinomas as well as in invasive implants associated with SBTs. BRAF mutations in SBTs may prevent SBTs from progressing to invasive carcinomas. On the other hand, the reported percentage of BRAF mutations in mucinous carcinoma (20% is much higher than that of mucinous borderline tumor (5%. Further investigation of the role of BRAF mutations in SBTs and mucinous tumor will shed light on the molecular mechanism underlying the role of BRAF mutations in tumor progression in different cellular context and the clinical utility of BRAF mutations in SBTs as a biomarker of favorable prognosis.Keywords: BRAF V600E, ovarian cancer, COLD-PCR

  17. MemBrain: improving the accuracy of predicting transmembrane helices.

    Directory of Open Access Journals (Sweden)

    Hongbin Shen

    Full Text Available Prediction of transmembrane helices (TMH in alpha helical membrane proteins provides valuable information about the protein topology when the high resolution structures are not available. Many predictors have been developed based on either amino acid hydrophobicity scale or pure statistical approaches. While these predictors perform reasonably well in identifying the number of TMHs in a protein, they are generally inaccurate in predicting the ends of TMHs, or TMHs of unusual length. To improve the accuracy of TMH detection, we developed a machine-learning based predictor, MemBrain, which integrates a number of modern bioinformatics approaches including sequence representation by multiple sequence alignment matrix, the optimized evidence-theoretic K-nearest neighbor prediction algorithm, fusion of multiple prediction window sizes, and classification by dynamic threshold. MemBrain demonstrates an overall improvement of about 20% in prediction accuracy, particularly, in predicting the ends of TMHs and TMHs that are shorter than 15 residues. It also has the capability to detect N-terminal signal peptides. The MemBrain predictor is a useful sequence-based analysis tool for functional and structural characterization of helical membrane proteins; it is freely available at http://chou.med.harvard.edu/bioinf/MemBrain/.

  18. Detection of unsuspected colonic abnormalities using the pneumocolon technique during small bowel meal examination

    Energy Technology Data Exchange (ETDEWEB)

    Chou, S.; Skehan, S.J.; Brown, A.L.; Rawlinson, J.; Somers, S

    2000-06-01

    AIMS: The pneumocolon technique in small bowel meal examination is used to obtain double-contrast views of the distal ileum. The purpose of this study was to determine the proportion of cases in which an overhead pneumocolon radiograph demonstrated clinically relevant findings in the colon. METHODS: The overhead pneumocolon radiographs in 151 patients who underwent small bowel meals were evaluated retrospectively. A chart review was performed on those patients with positive colonic findings to determine if the suspected abnormalities affected patient management. RESULTS: Colonic abnormalities were identified in 34 of the 151 patients. One patient had a previously undiagnosed ascending colonic cancer; 17 had evidence of acute or chronic colitis; 13 had diverticulosis; one had a caecal polyp; one had an ileosigmoid fistula; one had a filling defect in the ascending colon. In 25 cases the colonic abnormality was visible only on the pneumocolon radiograph and not on the preceding single-contrast images. Management was altered by the colonic findings in seven cases. False-positive findings occurred in two cases. CONCLUSIONS: A routine overhead radiograph following use of the pneumocolon technique is a useful adjunct to small bowel meal examination as it can yield unsuspected and clinically significant colonic findings. Chou, S. (2000)

  19. ABSTRACTS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@CONCURRENT SESSION: FOOD AND WATERBORNE DISEASES      Chair  Prof. Liu Xiu-mei, Institute of Nutrition and Food Hygiene (CAPM), China   Co-chair   Dr. Jorgen Schlundt, World Health Organization, Switzerland   1530-1545 hrs Emerging Foodborne Disearse: An Evolving Public Health Challenge   Robert Baldwin, Center for Disease Control, USA   1545-1600 hrs Food Poisoning Typicality in Food Safety Vulnerable Area of Indonesia   Adil Basuki Abza, Bogor Agricultural University, Indonesia   1600-1615 hrs The Management of Food Poisoning in China   Li Tai-ran, Institute of Food Safety Control and Inspection, Ministry of Health, China   1615-1630 hrs Detection of Campylobacter Species Using a Fluorogenic Real-Time PCR Detection System   Hai-yan Wang, Bureau of Microbial Hazards, Health Canada, Canada   1630-1645 hrs An Overview on Bongkrekic Acid Food Poisoning   Liu Xiu-mei, Institute of Nutrition and Food Hygiene (CAPM), China   1645-1700 hrs Screening Procedure from Cattle Feces and the Prevalence of Escherichia coli O157 in Taiwan Dairy Cattle   Chin-Cheng Chou, Taiwan University, Taibei, China

  20. Benefits of Either Operative or Non-Operative Treatment for Perilunate Dislocation and Fracture Dislocations

    Directory of Open Access Journals (Sweden)

    Michael Rivlin

    2014-03-01

    Full Text Available Dear Editor We read the article by Bagheri et al with great interest (1. We found the study interesting and comprehensive as four groups of patients, including operative and nonoperative in either pure dislocation or fracture dislocation, were compared in terms of Mayo wrist score, Grip strength, range of motion and radiographic parameters. It seems that the results were comparable to studies by Capo, Chou, Laporte, Malovic, Kremer, Forli and Lutz (Table 1 (2-8. In the studies listed above, all the patients were treated by operative fixation and none of them reported any experience with non-operative treatment (2-8. Their operative results are almost similar to Bagheri’s operative results in which they demonstrated better outcomes in terms of motion and Mayo score than the non-operative counterpart. In the current study by Bagheri et al, non-operative treatment is also discussed, which has little literature support so far (1. We wonder what the indications were leading the patient and the surgeon electing nonoperative treatment versus operative intervention. Since the outcomes of non-operative care were comparable to the operative outcomes, weighing the benefits of non surgical management may be an area of further investigation.The authors didn’t describe the operative intervention in detail making comparisons with outer studies difficult. Therefore, we note the need to compare different operative techniques in the literature to figure out which provide the most optimal outcomes and expedite patients’ rehabilitation.

  1. Defeating the fear: new insights into the neurobiology of stress susceptibility.

    Science.gov (United States)

    Krishnan, Vaishnav

    2014-11-01

    The psychopathological impact of emotional stress on a specific individual varies markedly: while most escape the development of post-traumatic stress disorder and/or major depression, a select group of individuals demonstrate a vulnerability to succumb to these conditions. The past decade has witnessed an explosion in animal research into the underlying neurobiological mechanisms that govern both vulnerability and resilience to such stressors. In the May 2014 issue, Chou and colleagues employ the mouse social defeat model of chronic stress to demonstrate that defeated susceptible mice display an exaggerated conditioned fear response associated with more pronounced autonomic changes. These physiological alterations were found to be mediated via local increases in the levels of brain derived neurotrophic factor (BDNF) within the basolateral amygdala and could be inhibited by the systemic administration of a beta adrenergic antagonist. This mini-review critically examines this manuscript's new mechanistic insights in light of previous results employing similar approaches. The strengths and limitations of the social defeat model, as well as the relevance of these findings to neurologic illness are discussed briefly.

  2. Training set reduction methods for protein secondary structure prediction in single-sequence condition.

    Science.gov (United States)

    Aydin, Zafer; Altunbasak, Yucel; Pakatci, Isa Kemal; Erdogan, Hakan

    2007-01-01

    Orphan proteins are characterized by the lack of significant sequence similarity to database proteins. To infer the functional properties of the orphans, more elaborate techniques that utilize structural information are required. In this regard, the protein structure prediction gains considerable importance. Secondary structure prediction algorithms designed for orphan proteins (also known as single-sequence algorithms) cannot utilize multiple alignments or alignment profiles, which are derived from similar proteins. This is a limiting factor for the prediction accuracy. One way to improve the performance of a single-sequence algorithm is to perform re-training. In this approach, first, the models used by the algorithm are trained by a representative set of proteins and a secondary structure prediction is computed. Then, using a distance measure, the original training set is refined by removing proteins that are dissimilar to the given protein. This step is followed by the re-estimation of the model parameters and the prediction of the secondary structure. In this paper, we compare training set reduction methods that are used to re-train the hidden semi-Markov models employed by the IPSSP algorithm [1]. We found that the composition based reduction method has the highest performance compared to the alignment based and the Chou-Fasman based reduction methods. In addition, threshold-based reduction performed better than the reduction technique that selects the first 80% of the dataset proteins.

  3. Soft Skill Competencies, Hard Skill Competencies, and Intention to Become Entrepreneur of Vocational Graduates (P.119-132

    Directory of Open Access Journals (Sweden)

    Benedicta Prihatin Dwi Riyanti

    2017-02-01

    Full Text Available This study aimed to determine the effect of soft skill competencies and hard skill competencies to the intention to become entrepreneur in the vocational school graduates. Hard skill entrepreneurial competencies are competencies that are needed to running business. Meanwhile for soft skill competencies are competencies related to aspects of personality and cognitive style. Population in this research is vocational graduates in Jakarta and Jogjakarta. The sampling technique used is incidental sampling. We used measuring instruments as follow:  the intention to become entrepreneur of Shapero & Sokol (in Riyanti, 2009. soft skill competencies of Spencer & Spencer (1993 and hard skill competencies of Chou. Shen. Hsiou & Chen. 2010. The regression analysis of the 258 respondents showed significant effect of soft skill competencies (initiative. self-confidence and assertiveness to the intention to become entrepreneur in the vocational school graduates. There are significant effect hard skill competencies (human resources capability competency and production capability competency to the intention to be entrepreneur. Based on the results. we suggested that the learning process should be more emphasis on direct practice so that more competencies can be formed on vocational school graduates.Keywords: entrepreneur,competency,intention

  4. Soft Skill Competencies, Hard Skill Competencies, and Intention to Become Entrepreneur of Vocational Graduates

    Directory of Open Access Journals (Sweden)

    Benedicta Prihatin Dwi Riyanti

    2016-08-01

    Full Text Available This study aimed to determine the effect of soft skill competencies and hard skill competencies to the intention to become entrepreneur in the vocational school graduates. Hard skill entrepreneurial competencies are competencies that are needed to running business. Meanwhile for soft skill competencies are competencies related to aspects of personality and cognitive style. Population in this research is vocational graduates in Jakarta and Jogjakarta. The sampling technique used is incidental sampling. We used measuring instruments as follow: the intention to become entrepreneur of Shapero & Sokol (in Riyanti, 2009. soft skill competencies of Spencer & Spencer (1993 and hard skill competencies of Chou. Shen. Hsiou & Chen. 2010. The regression analysis of the 258 respondents showed significant effect of soft skill competencies (initiative. self-confidence and assertiveness to the intention to become entrepreneur in the vocational school graduates. There are significant effect hard skill competencies (human resources capability competency and production capability competency to the intention to be entrepreneur. Based on the results. we suggested that the learning process should be more emphasis on direct practice so that more competencies can be formed on vocational school graduates.

  5. Brain meningioma with initial manifestation similar to cervical radiculopathy: a case report

    Directory of Open Access Journals (Sweden)

    Huang YH

    2014-06-01

    Full Text Available Yu-Hsuan Huang,1,* Chang-Zern Hong,2,* Wei-Ting Wu,1 Kun-Ta Li,3 Li-Wei Chou1,4¹Department of Physical Medicine and Rehabilitation, China Medical University Hospital, 2Department of Physical Therapy, Hungkuang University, 3Department of Emergency Medicine, China Medical University Hospital, 4School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan*These authors contributed equally to this workAbstract: Meningiomas are the most common benign brain tumors, and are characterized by slow growth and a long asymptomatic period. Once the tumor becomes symptomatic, the various presentations may be related to the location and compression of adjacent structures. Meningioma is primarily treated through surgical intervention, and thus earlier diagnosis is likely to result in better prognosis. The symptoms of the meningioma may mimic other diseases, making precise diagnosis difficult, which will then delay treatment. We report a case of brain meningioma that showed initial signs and symptoms similar to cervical radiculopathy. The symptoms extended gradually, and the ultimate diagnosis of meningioma was confirmed based on brain-image studies. After brain-tumor excision, postoperation radiotherapy, and aggressive rehabilitation, the patient was able to perform better in daily activities.Keywords: hemiplegia, menigioma, paresthesia, radiculopathy, rehabilitation

  6. Morphological development and oxidation of elongated {beta}-SiAlON material

    Energy Technology Data Exchange (ETDEWEB)

    Hou Xinmei, E-mail: houxinmei@ustb.edu.c [Department of Physical Chemistry, School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Key Laboratory of Ecological and Recycle Metallurgy, Ministry of Education, Beijing 100083 (China); Yue Changsheng [Department of Physical Chemistry, School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Singh, Ankit Kumar [Department of Physical Chemistry, School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Department of Ceramic Engineering, Institute of Technology, Banaras Hindu University, Varanasi 221 005 (India); Zhang Mei; Chou Kuo-Chih [Department of Physical Chemistry, School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083 (China)

    2011-06-15

    Research highlights: {yields} Single phase {beta}-SiAlON whiskers and ribbons with z value of 1.6 have been prepared. {yields} The oxidation of the {beta}-SiAlON whiskers and ribbons in air has been investigated. {yields} A new kinetic theory has been used to deal with the experimental results with a good agreement. {yields} The characteristic oxidation time has been introduced for measuring the oxidation resistance. - Abstract: Elongated {beta}-SiAlON whiskers and ribbons have been synthesized at 1700 K under flowing nitrogen atmosphere. A series of experiments have been performed using thermogravimetry (TG) and thermal field emission scanning electron microscope (FE-SEM) to investigate its oxidation resistance. The results showed that the synthesized {beta}-SiAlON material possessed good oxidation resistance and the shape can be well kept up to 1373 K. Chou's model has been used to investigate the oxidation kinetics, from which it was concluded that {beta}-SiAlON in shape of ribbons has better oxidation resistance than that in shape of whisker from the view point of a new index of the characteristic oxidation time.

  7. Identification of marker compounds for Japanese Pharmacopoeia non-conforming jujube seeds from Myanmar.

    Science.gov (United States)

    Oshima, Naohiro; Zaima, Kazumasa; Kamakura, Hiroyuki; Hamato, Akane; Yamamoto, Yutaka; Kang, Dong Hyo; Yokokura, Tsuguo; Goda, Yukihiro; Hakamatsuka, Takashi; Maruyama, Takuro

    2015-01-01

    Jujube seed is a crude drug defined as the seed of Ziziphus jujuba Miller var. spinosa Hu ex H.F. Chou (Rhamnaceae) in the Japanese Pharmacopoeia (JP). Most of the jujube seed in the Japanese markets is imported from China, with the rest obtained from other Asian countries. Here we confirmed the botanical origins of jujube seeds from both China and Myanmar by a DNA sequencing analysis. We found that the botanical origins of the crude drugs from China and Myanmar were Z. jujuba and Z. mauritiana, respectively. Although the jujube seed from China conforms to the JP, that from Myanmar does not. A method for discriminating jujube seeds from China and Myanmar using a chemical approach is thus desirable, and here we sought to identify a compound specific to Z. jujuba. Jujuboside A (1) was identified as a compound specific to Z. jujuba. To establish a purity test of Jujube Seed in the JP against Z. mauritiana, we fractionated the extract of Z. mauritiana seeds and identified frangufoline (2) and oleanolic acid (4) as the marker compounds specific to Z. mauritiana. Thin-layer chromatography (TLC) and gas chromatography-mass spectrometry analyses revealed that the latter compound was useful for testing by TLC analysis. The established TLC conditions were as follows: chromatographic support, silica gel; developing solvent, n-hexane:EtOAc:HCOOH = 10:5:1; developing length, 7 cm; visualization, diluted sulfuric acid; R f value, 0.43 (oleanolic acid).

  8. Effectively managing intractable central hyperthermia in a stroke patient by bromocriptine: a case report

    Directory of Open Access Journals (Sweden)

    Yu KW

    2013-05-01

    Full Text Available Kuo-Wei Yu,1,* Yu-Hui Huang,2,3 Chien-Lin Lin,1,4,* Chang-Zern Hong,5 Li-Wei Chou1,41Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 3Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan; 4School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 5Department of Physical Therapy, Hungkuang University, Taichung, Taiwan*These authors contributed equally to this workAbstract: Central hyperthermia is characterized by a rapid onset, high temperature, marked temperature fluctuation, and poor response to antipyretics and antibiotics. Although poststroke central hyperthermia is common, prolonged instances are rare. We report a case of prolonged central fever after an intracranial hemorrhage. Before the accurate diagnosis and management of central fever, the patient underwent long-term antibiotic use that led to pseudomembranous colitis. Bromocriptine was used to treat the prolonged central hyperthermia, after which the fever did not exceed 39°C. A week later, the body temperature baseline was reduced to 37°C and a low-grade fever with minor temperature fluctuation occurred only a few times. No fever occurred in the month following the treatment. After the fever subsided, the patient could undergo an aggressive rehabilitation program.Keywords: bromocriptine, central hyperthermia, fever, stroke

  9. Composition dependences of thermodynamical properties associated with Pb-free ternary, quaternary, and quinary solder systems

    Science.gov (United States)

    Dogan, A.; Arslan, H.

    2016-05-01

    In the present study, Chou's General Solution Model (GSM) has been used to predict the enthalpy and partial enthalpies of mixing of the liquid Ag-In-Sn ternary, Ag-In-Sn-Zn quaternary, and Ag-Au-In-Sn-Zn quinary systems. These are of technical importance to optimize lead-free solder alloys, in selected cross-sections: x In/ x Sn = 0.5/0.5 (ternary), Au-In0.1-Sn0.8-Zn0.1, Ag-In0.1-Sn0.8-Zn0.1 (quaternary), and t = x Au/ x In = 1, x In = x Sn = x Zn (quinary) at 1173, 773, and 773 K, respectively. Moreover, the activity of In content in the ternary alloy system Ag-In-Sn has been calculated and its result is compared with that determined from the experiment, while the activities of Ag contents associated with the alloys mentioned above have been calculated. The other traditional models such as of Colinet, Kohler, Muggianu, Toop, and Hillert are also included in calculations. Comparing those calculated from the proposed GSM with those determined from experimental measurements, it is seen that this model becomes considerably realistic in computerization for estimating thermodynamic properties in multicomponent systems.

  10. Determinations of enthalpy and partial molar enthalpy in the alloys Bi–Cd–Ga–In–Zn, Bi–Cd–Ga–Zn and Au–Cu–Sn

    Energy Technology Data Exchange (ETDEWEB)

    Arslan, Hüseyin, E-mail: hseyin_arslan@yahoo.com

    2015-03-01

    In the present study, the relations of thermodynamic associated with Chou's general solution model (GSM), the models of Muggianu and Toop have been used in order to calculate the mixing enthalpy and partial molar mixing enthalpy of mixing of Bi–Cd–Ga–In–Zn, Bi–Cd–Ga–Zn with equimolar section at a temperature of 730 K and Au–Cu–Sn with the section x{sub Au}/x{sub Cu} = 1/1 on the entire molar fraction range as a function of alloy composition at a temperature of 900 K. Some negativities are reported in the selected alloys mentioned above, particularly at high temperatures for the human health as well as difficulties in experimental measurement and high costs. Moreover, aim of us is to close the current article gap seen in the literature. In order to close the current gap seen in the literature, the article on the thermodynamic properties of the Bi–Cd–Ga–In–Zn alloys are presented in this study. - Highlights: • Thermodynamic properties of alloys in the study in given conditions were treated. • The activity of Bi seen in all models shows greatly positive deviation from ideality. • The enthalpy of Sn shows small negative values in x{sub Au}/x{sub Cu} = 1 at 900 K. • The activity of Sn shows negative deviation from ideality in the same conditions.

  11. Screening Insecticide for Controlling Chilo Suppressalis and Cnaphalocrocis Medinalis In East of Hebei Rice Area%冀东稻区防治二化螟、稻纵卷叶螟的药剂筛选研究

    Institute of Scientific and Technical Information of China (English)

    韩民利; 邢春强; 张晓东; 祁开利; 曹连志

    2009-01-01

    2008年选择了四种杀虫剂进行了防治水稻二化螟、稻纵卷叶螟的田间药剂试验,结果显示:20%康宽(CoregenTM)150ml/hm2防效最好,其杀虫、保穗和保叶效果均超过95%,50%灵蛙1200ml/hm2、20%解千愁1350ml/hm2,15%阿维毒1800ml/hm2防治效果也较理想,其杀虫、保穗和保叶作用分别达90%左右,4种新型杀虫剂的防治效果显著优于常规药剂--90%杀虫单sp(900g/hm2)18%杀虫双(3000g/hm2),在试验剂量下,4种杀虫剂对水稻的正常生长无影响,安全性好.%Four different types of insecticides were steted on their controlling effects on Chllo suppressalis and Cnaphaloerocis medinalis .The results showed that 20% Coregen TM gave the best results and 50% Ling Wa EC ande 20% Jie qian chou EC and 15% A wei du also gave good effects. They all showed no damage on rice growth.

  12. Study on Stress Concentrations in an Intraply Hybrid Composite Sheet%层内混杂复合材料应力集中问题的研究

    Institute of Scientific and Technical Information of China (English)

    曾庆敦; 黄小清; 林雪慧

    2001-01-01

    提出了一种合理、简便、精确的修正的剪滞模型,基于此模型,分析了受拉伸的层内混杂复合材料中某些纤维断裂后的应力重分布,结果表明,求得的应力集中因子与Fukuda和Chou的结果相当接近,从而证实了本文模型和方法的合理性和正确性,%A reasonably, simply and accurately modified shear_lag model was proposed. Based on the model, the stress redistributions due to the failure of some fibers in an intraply hybrid composite under tension were analyzed. The results show that the present calculating stress concentration factors very coincide with Fukuda and Chou's results, thus verifying the reasonableness and correctness of the present model and methods.

  13. Essai sur le rôle d’une espèce végétale rustique pour un développement durable de la steppe algérienne

    Directory of Open Access Journals (Sweden)

    Benabdeli Khéloufi

    2006-07-01

    Full Text Available La steppe en Algérie est un espace stratégique en matière de lutte contre la désertification, il couvre plus de 20 millions d’hectares et connaît une dégradation importante. Différents programmes de protection et de réhabilitation de cet espace ont échoué et sont souvent à l’origine de l’aggravation de cette dégradation. Une synthèse sur les causes de cet échec permettront de proposer une nouvelle approche axée sur l’introduction d’une espèce végétale très rustique et dont l’impact écologique pourrait sauver la steppe.The steppe in Algeria is a strategic space as regards to the control of desertification, it covers more than 20 million hectares and knows an important degradation. Various programmes of protection and rehabilitation concerning this space failed and are at the origin of the aggravation of this degradation. A synthesis of the causes of this failure will make it possible to propose a new approach centered on the introduction of a very rustic plant species and whose ecological impact could save the steppe.

  14. In silico analysis and modeling of ACP-MIP–PilQ chimeric antigen from Neisseria meningitidis serogroup B

    Science.gov (United States)

    Gholami, Mehrdad; Salimi Chirani, Alireza; Moshiri, Mona; Sedighi, Mansour; Pournajaf, Abazar; Tohidfar, Masoud; Irajian, Gholamreza

    2015-01-01

    Background: Neisseria meningitidis, a life-threatening human pathogen with the potential to cause large epidemics, can be isolated from the nasopharynx of 5–15% of adults. The aim of the current study was to evaluate biophysical and biochemical properties and immunological aspects of chimeric acyl-carrier protein-macrophage infectivity potentiator protein-type IV pilus biogenesis protein antigen (ACP-MIP-PilQ) from N. meningitidis serogroup B strain. Methods: Biochemical properties and multiple alignments were predicted by appropriate web servers. Secondary molecular structures were predicted based on Chou and Fasman, Garnier-Osguthorpe-Robson, and Neural Network methods. Tertiary modeling elucidated conformational properties of the chimeric protein. Proteasome cleavage and transporter associated with antigen processing (TAP) binding sites, and T- and B-cell antigenic epitopes, were predicted using bioinformatic web servers. Results: Based on our in silico and immunoinformatics analyses, the ACP-MIP-PilQ protein (AMP) can induce high-level cross-strain bactericidal activity. In addition, several immune proteasomal cleavage sites were detected. The 22 epitopes associated with MHC class I and class II (DR) alleles were confirmed in the AMP. Thirty linear B-cell epitopes as antigenic regions were predicted from the full-length protein. Conclusion: All predicted properties of the AMP indicate it could be a good candidate for further immunological in vitro and in vivo studies. PMID:26989750

  15. Computational studies on LiP H isolated from Ganoderma lucidum GD88

    Directory of Open Access Journals (Sweden)

    Parambayil Nayana

    2015-01-01

    Full Text Available Ganoderma lucidum is a basidiomycete fungus that produces ligninase for the modification of lignin. Lignin peroxidase (LiP is a glycoprotein that acts on the recalcitrant cell wall component lignin. In the present study, the phylogenetic analysis of Ganoderma lucidum GD88 with the partial coding sequence (cds of other LiP isoforms was performed using MEGA6. After determination of the open reading frame, the +3 frame nucleotide sequence was converted to protein using the EMBOSS Transseq and the secondary structure was predicted using the Chou and Fasman Secondary Structure Prediction server (CFSSP. Protein modeling was also performed by SWISS-MODEL. The obtained result shows that the lipH partial cds of Ganoderma lucidum GD88 is homologous to the lipD gene of Phanerochaete chrysosporium. The secondary structure prediction result revealed that the percent content of the helix (67 is higher than the percent contents of sheet (53.4 and turns (13.6. According to the generated model, LiP H protein is a homodimer with chains A and B. The heme acts as a ligand and plays a major role in structure stabilization.

  16. Prediction of Secondary Structure and B Cell Epitope of GH Protein from Acipenser sinensis%中华鲟GH蛋白二级结构和B细胞抗原表位的预测

    Institute of Scientific and Technical Information of China (English)

    刘红艳; 杨东; 张繁荣; 余来宁

    2009-01-01

    [Objective] The aim was to predict the secondary structure and B cell epitope of growth hormone (GH) protein from Acipenser sinensis. [Method] With the amino acid sequence of GH protein from A.sinensis as the base, the secondary structure of GH protein from A.sinensis was predicted by the method of Garnier-Robson, Chou-Fasman and Karplus-Schulz, and its cell epitope was predicted by the method of Kyte-Doolittle, Emini and Jameson-Wolf. [Result] The sections of 18-23, 55-56, 67-73, 83-86, 112-114, 151-157 and 209-211 in the N terminal of GH protein molecule had softer structure and these sections could sway or fold to produce more complex tertiary structure. The sections of 19-23, 51-71, 84-95, 128-139, 164-176 and 189-196 in the N terminal of GH protein could be the epitope of B cell and there were flexible regions in these sections or near these sections of GH protein molecule. So the dominant regions could be in these sections or near these sections. [Conclusion] The research provided the basis for the preparation of monoclonal antibody of GH protein from A.sinensis and provided the reference for the discussion for the molecular regulation mechanism of A.sinensis.

  17. Chronic exposure to pulsed low-intensity microwaves is carcinogenic and tumorogenic

    Science.gov (United States)

    Lundquist, Marjorie

    2004-03-01

    To study health effects of lifetime exposure to low-intensity pulsed radiation >890 MHz, one controlled laboratory study of SPF* rats[1-3] and two of mice[4,5] were conducted, but only one[4] reported that its data showed an association between irradiation and cancer; reports of the other two studies minimized or denied such association. Critical review of these identified data evaluation errors; their correction enables a conclusion of microwave carcinogenicity from each study (the rat study also shows an association with endocrine-system primary malignancies and with a benign tumor of the adrenal medulla), enhancing the credibility of an epidemiological study[6] reporting a brain cancer risk for users of both analog and digital cellular phones. [1] J. Raloff. Science News 126(7):103(1984). [2] K. R. Foster & A. W. Guy. Sci Am 255(3):32-39(1986). [3] C.-K. Chou et al. Bioelectromagnetics 13:469-496(1992). [4] M. H. Repacholi et al. Radiat Res 147:631-640(1990)SPF\\. [5] T. D. Utteridge et al. Radiat Res 158:357-364(2002)non-SPF\\. [6] L. Hardell et al. Int J Oncol 22:399-407(2003). * SPF = specific-pathogen-free

  18. Borehole data package for well 299-W15-41 at single-shell tank waste management Area TX-TY

    Energy Technology Data Exchange (ETDEWEB)

    DG Horton; FN Hodges

    2000-06-01

    One new Resource Conservation and Recovery Act (RCRA) groundwater monitoring well was installed at the single-shell tank farm Waste Management Area (WMA) TX-TY during December 1999 and January 2000 in fulfillment of Tri-Party Agreement (Ecology 1996) milestone M-24-43. The well is 299-W15-41 and is located south of the 241-TX tank farm and south of 20th Street in the 200 West Area. A figure shows the locations of all wells in the WMA TX-TY monitoring network. The new well was constructed to the specifications and requirements described in Washington Administrative Code (WAC) 173-160 and WAC 173-303, the groundwater monitoring plan for WMA TX-TY (Caggiano and Goodwin 1991), the assessment plan for WMA TX-TY (Caggiano and Chou 1993), and the description of work for well drilling and installation. This document compiles information on the drilling and construction, well development, pump installation, and sediment testing applicable to well 299-W1 5-41. Appendix A contains the geologist's log, the Well Construction Summary Report, and Well Summary Sheet (as-built diagram) and Appendix B contains borehole geophysical logs. Additional documentation concerning well construction is on file with Bechtel Hanford, Inc., Richland, Washington.

  19. Synergistic Effect between Cisplatin and Sunitinib Malate on Human Urinary Bladder-Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Regina Arantes-Rodrigues

    2013-01-01

    Full Text Available The aim of this paper is to analyse sunitinib malate in vitro ability to enhance cisplatin cytotoxicity in T24, 5637, and HT1376 human urinary bladder-cancer cell lines. Cells were treated with cisplatin (3, 6, 13, and 18 μM and sunitinib malate (1, 2, 4, 6, and 20 μM, either in isolation or combined, over the course of 72 hours. 3-(4,5-Dimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide assay, acridine orange, and monodansylcadaverine staining and flow cytometry were performed. The combination index (CI was calculated based on the Chou and Talalay method. In isolation, cisplatin and sunitinib malate statistically (. Autophagy and apoptosis studies showed a greater incidence when the combined treatment was put into use. This hints at the possibility of a new combined therapeutic approach. If confirmed in vivo, this conjugation may provide a means of new perspectives in muscle-invasive urinary bladder cancer treatment.

  20. INTRODUCTION TO CHINESE MEDICAL LITERATURE.

    Science.gov (United States)

    KAN, L B

    1965-01-01

    The history of medicine in China is divided into four periods, from about 2700 B.C. to the present. Brief descriptions of standard works of these periods (e.g. Pèn-Ts'ao, Nei Ching, Nan Ching, Shang Han Lun, Ch'in K'ue Yao Lüeh, Chai I Ching, Chou Hou Pei Chi Fang, Mo Ching, Ming I Pieh Lu, Ch'ao Shih Pin Yüan, Chien Chin Yao Fang, Wai T'ai Pi Yao, Hsi Yüan Lu, Pèn-Ts'ao Kang-Mu, etc.) are given. The latter part of the paper deals with the state of modern medical research and literature in Mainland China, where equal emphasis is placed on the practice of both traditional Chinese and Western medicine in the treatment of diseases, thus resulting in a new era in Chinese medical history. This is based on the information obtainable in Hong Kong. Information about medical developments in Taiwan is readily available elsewhere and so has been omitted.

  1. Wind Resource Assessment in Europe Using Emergy

    CERN Document Server

    Paudel, Subodh; Martin, Viktoria; Lacarriere, Bruno; Corre, Olivier Le

    2015-01-01

    In context of increasing use of renewable sources, it is of importance to correctly evaluate the actual sustainability of their implementation. Emergy analysis is one of the possible methods useful for such an assessment. This work aims to demonstrate how the emergy approach can be used to assess the sustainability of wind energy resource in Europe. The Emergy Index of Sustainability (EIS) and the Emergy Yield Ratio (EYR) are used to analyze 90 stations of European regions for three types of wind turbines. To do so, the simplified Chou wind turbine model is used for different set of parameters as: nominal power and size of the wind turbines, and cut-in and cut-out wind speeds. Based on the calculation of the emergy indices, a mapping is proposed to identify the most appropriate locations for an implementation of wind turbines in European regions. The influence of the wind turbine type on the sustainability is also analyzed, in link with the local wind resource. Thus, it is concluded that the emergy sustainabi...

  2. Signal-CF: a subsite-coupled and window-fusing approach for predicting signal peptides.

    Science.gov (United States)

    Chou, Kuo-Chen; Shen, Hong-Bin

    2007-06-01

    We have developed an automated method for predicting signal peptide sequences and their cleavage sites in eukaryotic and bacterial protein sequences. It is a 2-layer predictor: the 1st-layer prediction engine is to identify a query protein as secretory or non-secretory; if it is secretory, the process will be automatically continued with the 2nd-layer prediction engine to further identify the cleavage site of its signal peptide. The new predictor is called Signal-CF, where C stands for "coupling" and F for "fusion", meaning that Signal-CF is formed by incorporating the subsite coupling effects along a protein sequence and by fusing the results derived from many width-different scaled windows through a voting system. Signal-CF is featured by high success prediction rates with short computational time, and hence is particularly useful for the analysis of large-scale datasets. Signal-CF is freely available as a web-server at http://chou.med.harvard.edu/bioinf/Signal-CF/ or http://202.120.37.186/bioinf/Signal-CF/.

  3. Optimal root profiles in water-limited ecosystems

    Science.gov (United States)

    Rudd, Keith; Albertson, John D.; Ferrari, Silvia

    2014-09-01

    The vertical distribution of roots in the soil is of central importance to the mass and energy exchange between the land and the atmosphere. It has been demonstrated that the vertical root profiles which maximize transpiration in numerical experiments reflect well the characteristics of root profiles observed in nature for water-limited ecosystems. Previous research has demonstrated how the optimal vertical root profile depends on both the mean annual precipitation (MAP) and the soil texture. Recently, in the climate literature, it has been suggested Chou et al. (2012) [5] that increased greenhouse forcing in the tropics can lead to a simultaneous decrease in the frequency and increase in the intensity of precipitation. In this paper we demonstrate how such a change in the statistical structure of rainfall, even with no change to MAP, requires deeper root distributions to maintain optimal water use. These results raise interesting questions for future studies of nutrient dynamics, the cost of additional below ground carbon allocation, and inter plant functional type competition.

  4. Antecedents dan Consequences dari Feedback-Seeking Orientation di Costa Crociere

    Directory of Open Access Journals (Sweden)

    Trias Septyoari Putranto

    2012-11-01

    Full Text Available Cruise ship, as a home away from home place, which has a perisable product with the complex activity from their employees, certainly should have a potential character to keep sustainable in the service industry. To keep it sustainable, the management should have a good relationship with their employees and customers. In this research, a good relationship with the employee can be created by a good motivation, leadership, and it has an effect with the feedback. This condition can be seen by the employees’ job satisfaction. The management can drive a conductive working condition to help generate a good service climate. The research was undertaken in a cruise ship service industry in Italy. The purpose of this study was to evaluate the effect of employees’ motivation and leadership of feedback-seeking orientation and their job satisfaction. Sample was collected from 100 respondents, the employees’, with simple random sampling method, questionnaire, and an interview with the management. The collected data was analyzed with path analysis which using the statistic program LISREL 8.7 for Windows, and the questionnaire was adopted from Paswan (2005 and Chou (2002. The findings suggest that motivation and leadership have a significant effect on feedback-seeking orientation. Besides, feedbackseeking orientation also has a significant effect on job satisfaction.

  5. Coprescription of Chinese herbal medicine and Western medication among female patients with breast cancer in Taiwan: analysis of national insurance claims

    Directory of Open Access Journals (Sweden)

    Wang BR

    2014-05-01

    Full Text Available Bih-Ru Wang,1,2,* Yuh-Lih Chang,1,2,* Tzeng-Ji Chen,3,4 Jen-Hwey Chiu,5,6 Jing Chong Wu,7 Min-Shan Wu,1 Chia-Lin Chou,1 Yueh-Ching Chou1,2,81Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan; 2Department and Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan; 3Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 4Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan; 5Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; 6Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 7Traditional Medicine Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 8College of Pharmacy, Taipei Medical University, Taipei, Taiwan*These authors contributed equally to this workBackground: Many female breast cancer (FBC patients take Chinese herbal medicine (CHM and Western medication (WM concurrently in Taiwan. Despite the possibility of interactions between the CHM and WM mentioned in previous studies, the pattern of these coprescriptions in FBC patients remains unclear. Hence, the aim of the present study is to investigate the utilization of coprescriptions of CHM and WM among the FBC patients in Taiwan.Methods: The study was a cross-sectional survey using the sampled cohort in 2009 obtained from the National Health Insurance Research Database in Taiwan. There were 3,507 FBC patients identified from the registry for catastrophic illness patients. Ambulatory visit records, corresponding prescriptions, and the data of beneficiaries belonging to the FBC patients were further extracted. A total of 1,086 FBC patients used CHM at least once. CHM and WM prescribed within any overlapping duration were defined as coprescriptions.Results: There were 868 (80.0% patients simultaneously receiving CHM and WM. A total of 4,927 CHM prescriptions and 6,358 WM

  6. Potential role of pre- and postnatal testosterone levels in attention-deficit/hyperactivity disorder: is there a sex difference?

    Directory of Open Access Journals (Sweden)

    Wang LJ

    2017-05-01

    Full Text Available Liang-Jen Wang,1,2 Miao-Chun Chou,1 Wen-Jiun Chou,1 Min-Jing Lee,1 Sheng-Yu Lee,3,4 Pao-Yen Lin,5 Yi-Hsuan Lee,1 Yi-Hsin Yang,6 Cheng-Fang Yen2,7 1Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 2Department of Psychiatry, School of Medicine, and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 3Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, 4Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, 5Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 6School of Pharmacy, Kaohsiung Medical University Hospital, 7Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Objective: Both prenatal testosterone (T exposure and postnatal T levels have been associated with developing neural circuitry and behavioral systems. This study examined the potential correlation between pre- and postnatal T levels and behavioral and neurocognitive profiles of children with attention-deficit/hyperactivity disorder (ADHD.Methods: Two hundred ADHD patients with a mean age of 8.7±2.0 years (158 boys and 42 girls were recruited. The ratio of the length of the right index finger (2D to that of the right ring finger (4D (2D/4D ratio served as a surrogate of prenatal T exposure, and postnatal T was determined using salivary T concentration. Behavioral symptoms were evaluated using the Swanson, Nolan, and Pelham – Version IV Scale for ADHD (SNAP-IV. Neurocognitive function was assessed using the Wechsler Intelligence Scale for Children – Fourth Edition (WISC-IV and Conners’ Continuous Performance Test (CPT.Results: Lower 2D/4D ratios were associated with comorbid disruptive behavior disorders (t=2.15, P=0.033 in all participants. Among the boys with ADHD, neither 2D/4D ratios nor salivary T levels

  7. Association of 5' end neuregulin-1 (NRG1) gene variation with subcortical medial frontal microstructure in humans.

    Science.gov (United States)

    Winterer, Georg; Konrad, Andreas; Vucurevic, Goran; Musso, Francesco; Stoeter, Peter; Dahmen, Norbert

    2008-04-01

    Animal data suggest that the gene neuregulin-1 (NRG1) is involved in neuronal myelination. A haplotype (deCODE) in the 5' end region of the gene was described to double the risk for schizophrenia in an Icelandic population (Stefansson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., Chou, T.T., Hjaltason, O., Birgisdottir, B., Jonsson, H., Gudnadottir, V.G., Gudmundsdottir, E., Bjornsson, A., Ingvarsson, B., Ingason, A., Sigfusson, S., Hardardottir, H., Harvey, R.P., Lai, D., Zhou, M., Brunner, D., Mutel, V., Gonzalo, A., Lemke, G., Sainz, J., Johannesson, G., Andresson, T., Gudbjartsson, D., Manolescu, A., Frigge, M.L., Gurney, M.E., Kong, A., Gulcher, J.R., Petursson, H., Stefansson, K. 2002. Neuregulin-1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71, 877-892). Of note, there is now increasing evidence of disturbed myelination in this illness--particularly in subcortical frontal lobe white matter (Konrad, A., Winterer, G. 2008. Disturbed structural connectivity in schizophrenia--primary factor in pathology or epiphenomenon? Schiz. Bull. [Electronic publication ahead of print]). Therefore, we investigated with diffusion tensor imaging (DTI) the impact of a tagging single nucleotide polymorphism (SNP) from the deCODE haplotype, i.e., SNP8NRG221533, on fractional anisotropy (FA), which reflects structural integrity of white matter. SNP8NRG221533 was selected because it gave the single best uncorrected association with schizophrenia in the original report by Stefansson et al. (Stefansson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., Chou, T.T., Hjaltason, O., Birgisdottir, B., Jonsson, H., Gudnadottir, V.G., Gudmundsdottir, E., Bjornsson, A., Ingvarsson, B., Ingason, A., Sigfusson, S., Hardardottir, H., Harvey, R.P., Lai, D., Zhou, M., Brunner, D., Mutel, V., Gonzalo, A

  8. Virtual screening for SARS-CoV protease based on KZ7088 pharmacophore points.

    Science.gov (United States)

    Sirois, Suzanne; Wei, Dong-Qing; Du, Qishi; Chou, Kuo-Chen

    2004-01-01

    Pharmacophore modeling can provide valuable insight into ligand-receptor interactions. It can also be used in 3D (dimensional) database searching for potentially finding biologically active compounds and providing new research ideas and directions for drug-discovery projects. To stimulate the structure-based drug design against SARS (severe acute respiratory syndrome), a pharmacophore search was conducted over 3.6 millions of compounds based on the atomic coordinates of the complex obtained by docking KZ7088 (a derivative of AG7088) to SARS CoV M(pro) (coronavirus main proteinase), as reportedly recently (Chou, K. C.; Wei, D. Q.; Zhong, W. Z. Biochem. Biophys. Res. Commun. 2003, 308, 148-151). It has been found that, of the 3.6 millions of compounds screened, 0.07% are with the score satisfying five of the six pharmacophore points. Moreover, each of the hit compounds has been evaluated for druggability according to 13 metrics based on physical, chemical, and structural properties. Of the 0.07% compounds thus retrieved, 17% have a perfect score of 1.0; while 23% with one druggable rule violation, 13% two violations, and 47% more than two violations. If the criterion for druggability is set at a maximum allowance of two rule violations, we obtain that only about 0.03% of the compounds screened are worthy of further tests by experiments. These findings will significantly narrow down the search scope for potential compounds, saving substantial time and money. Finally, the featured templates derived from the current study will also be very useful for guiding the design and synthesis of effective drugs for SARS therapy.

  9. Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803.

    Science.gov (United States)

    Zhang, Xiu-Zhen; Wang, Ling; Liu, Dong-Wu; Tang, Guang-Yan; Zhang, Hong-Yu

    2014-09-01

    This study aims at evaluating the anticancer effects of berberine hydrochloride (berberine) and d-limonene, alone and in combination, on human gastric carcinoma cell line MGC803 to determine whether berberine and d-limonene work synergistically and elucidate their mechanisms. MGC803 cells were treated with berberine and d-limonene, alone and in combination, for 24-48 h. The inhibitory effects of these drugs on growth were determined by MTT assay. The combination index and drug reduction index were calculated with the Chou-Talalay method based on the median-effect principle. Flow cytometry and laser scanning confocal microscopy were employed to evaluate the effects of both drugs on cell-cycle perturbation and apoptosis, generation of reactive oxygen species (ROS), mitochondrial membrane potential, and expression of Bcl-2 and caspase-3 in MGC803 cells. Berberine or d-limonene alone can inhibit the growth of MGC803 cells in a dose- and time-dependent manner. Berberine and d-limonene at a combination ratio of 1:4 exhibited a synergistic effect on anti-MGC803 cells. The two drugs distinctly induced intracellular ROS generation, reduced the mitochondrial transmembrane potential (ΔΨm), enhanced the expression of caspase-3, and decreased the expression of Bcl-2. The combination of berberine and d-limonene showed more remarkable effects compared with drugs used singly in MGC803 cells. The combination of berberine and d-limonene exerted synergistic anticancer effects on MGC803 cells by cell-cycle arrest, ROS production, and apoptosis induction through the mitochondria-mediated intrinsic pathway.

  10. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2011-12-01

    Full Text Available Esther Captain en Guno Jones, Oorlogserfgoed overzee: De erfenis van de Tweede Wereldoorlog in Aruba, Curaçao, Indonesië en Suriname (Fridus StijlenCynthia Chou, The Orang Suku Laut of Riau, Indonesia: The inalienable gift of territory (Timothy P. BarnardMarshall Clark, Maskulinitas: Culture, gender and politics inIndonesia (Will DerksMatthew Isaac Cohen, Performing otherness: Java and Bali on international stages, 1905-1952 (SuryadiMarleen Dieleman, Juliette Koning and Peter Post (eds, Chinese Indonesians and regime change (Dewi AnggraeniWim van den Doel, Zo ver de wereld strekt: De geschiedenis van Nederland overzee vanaf 1800 (Hans HägerdalMichael Feener and Terenjit Sevea (eds, Islamicconnections: Muslim societies in South and Southeast Asia (Michael LaffanR. Michael Feener, Muslim legal thought in Modern Indonesia (Stijn Cornelis van HuisZane Goebel, Language, migration, and identity: Neighbourhood talk in Indonesia (Sheri Lynn GibbingsLizzy van Leeuwen, Lost in mall: An ethnography of middle-class Jakarta in the 1990s (Andy FullerAlfred W. McCoy, Policing America’s empire: The United States, the Philippines, and the rise of the surveillance state (Florentino RodaoFrans H. Peters, Vervlogen verwachtingen: De teloorgang van Nieuw-Guinea in 1961-1962 (Jaap TimmerChristina Schwenkel, The American war in contemporary Vietnam: Transnational remembrance and representation (Hans HägerdalYeoh Seng Guan, Loh Wei Leng, Khoo Salma Nasution and Neil Khor, Penang and its region: The story of an Asian entrepôt (David Kloos

  11. The development of 8 inch roll-to-plate nanoimprint lithography (8-R2P-NIL) system

    Science.gov (United States)

    Lee, Lai Seng; Mohamed, Khairudin; Ooi, Su Guan

    2017-07-01

    Growth in semiconductor and integrated circuit industry was observed in the past decennium of years for industrial technology which followed Moore's law. The line width of nanostructure to be exposed was influenced by the essential technology of photolithography. Thus, it is crucial to have a low cost and high throughput manufacturing process for nanostructures. Nanoimprint Lithography technique invented by Stephen Y. Chou was considered as major nanolithography process to be used in future integrated circuit and integrated optics. The drawbacks of high imprint pressure, high imprint temperature, air bubbles formation, resist sticking to mold and low throughput of thermal nanoimprint lithography on silicon wafer have yet to be solved. Thus, the objectives of this work is to develop a high throughput, low imprint force, room temperature UV assisted 8 inch roll to plate nanoimprint lithography system capable of imprinting nanostructures on 200 mm silicon wafer using roller imprint with flexible mold. A piece of resist spin coated silicon wafer was placed onto vacuum chuck drives forward by a stepper motor. A quartz roller wrapped with a piece of transparent flexible mold was used as imprint roller. The imprinted nanostructures were cured by 10 W, 365 nm UV LED which situated inside the quartz roller. Heat generated by UV LED was dissipated by micro heat pipe. The flexible mold detaches from imprinted nanostructures in a 'line peeling' pattern and imprint pressure was measured by ultra-thin force sensors. This system has imprinting speed capability ranging from 0.19 mm/s to 5.65 mm/s, equivalent to imprinting capability of 3 to 20 pieces of 8 inch wafers per hour. Speed synchronization between imprint roller and vacuum chuck was achieved by controlling pulse rate supplied to stepper motor which drive the vacuum chuck. The speed different ranging from 2 nm/s to 98 nm/s is achievable. Vacuum chuck height was controlled by stepper motor with displacement of 5 nm/step.

  12. HT-FRTC: a fast radiative transfer code using kernel regression

    Science.gov (United States)

    Thelen, Jean-Claude; Havemann, Stephan; Lewis, Warren

    2016-09-01

    The HT-FRTC is a principal component based fast radiative transfer code that can be used across the electromagnetic spectrum from the microwave through to the ultraviolet to calculate transmittance, radiance and flux spectra. The principal components cover the spectrum at a very high spectral resolution, which allows very fast line-by-line, hyperspectral and broadband simulations for satellite-based, airborne and ground-based sensors. The principal components are derived during a code training phase from line-by-line simulations for a diverse set of atmosphere and surface conditions. The derived principal components are sensor independent, i.e. no extra training is required to include additional sensors. During the training phase we also derive the predictors which are required by the fast radiative transfer code to determine the principal component scores from the monochromatic radiances (or fluxes, transmittances). These predictors are calculated for each training profile at a small number of frequencies, which are selected by a k-means cluster algorithm during the training phase. Until recently the predictors were calculated using a linear regression. However, during a recent rewrite of the code the linear regression was replaced by a Gaussian Process (GP) regression which resulted in a significant increase in accuracy when compared to the linear regression. The HT-FRTC has been trained with a large variety of gases, surface properties and scatterers. Rayleigh scattering as well as scattering by frozen/liquid clouds, hydrometeors and aerosols have all been included. The scattering phase function can be fully accounted for by an integrated line-by-line version of the Edwards-Slingo spherical harmonics radiation code or approximately by a modification to the extinction (Chou scaling).

  13. Protein Primary Structure of the Vaccinia Virion at Increased Resolution

    Science.gov (United States)

    Ngo, Tuan; Mirzakhanyan, Yeva; Moussatche, Nissin; Gershon, Paul David

    2016-11-01

    Here we examine the protein covalent structure of the vaccinia virus virion. Within two virion preparations, >88% of the theoretical vaccinia virus-encoded proteome was detected with high confidence, including the first detection of products from 27 open reading frames (ORFs) previously designated "predicted," "uncharacterized," "inferred," or "hypothetical" polypeptides containing as few as 39 amino acids (aa) and six proteins whose detection required nontryptic proteolysis. We also detected the expression of four short ORFs, each of which was located within an ORF ("ORF-within-ORF"), including one not previously recognized or known to be expressed. Using quantitative mass spectrometry (MS), between 58 and 74 proteins were determined to be packaged. A total of 63 host proteins were also identified as candidates for packaging. Evidence is provided that some portion of virion proteins are "nicked" via a combination of endoproteolysis and concerted exoproteolysis in a manner, and at sites, independent of virus origin or laboratory procedures. The size of the characterized virion phosphoproteome was doubled from 189 (J. Matson, W. Chou, T. Ngo, and P. D. Gershon, Virology 452-453:310-323, 2014, doi:http://dx.doi.org/10.1016/j.virol.2014.01.012) to 396 confident, unique phosphorylation sites, 268 of which were within the packaged proteome. This included the unambiguous identification of phosphorylation "hot spots" within virion proteins. Using isotopically enriched ATP, 23 sites of intravirion kinase phosphorylation were detected within nine virion proteins, all at sites already partially occupied within the virion preparations. The clear phosphorylation of proteins RAP94 and RP19 was consistent with the roles of these proteins in intravirion early gene transcription. In a blind search for protein modifications, cysteine glutathionylation and O-linked glycosylation featured prominently. We provide evidence for the phosphoglycosylation of vaccinia virus proteins.

  14. Pseudomembranous colitis within radiotherapy field following concurrent chemoradiation therapy: a case report

    Directory of Open Access Journals (Sweden)

    Shen BJ

    2013-01-01

    Full Text Available Bing-Jie Shen,1 Shih-Chiang Lin,2 Pei-Wei Shueng,1,3 Yueh-Hung Chou,4 Li-Ming Tseng,5 Chen-Hsi Hsieh1,6,71Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Division of Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan; 3Department of Radiation Oncology, National Defense Medical Center, Taipei, Taiwan; 4Department of Anatomical Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan; 5Division of Colorectal Surgery, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan; 6Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 7Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, TaiwanAbstract: Development of nonantibiotic-associated pseudomembranous colitis has been reported in patients receiving chemotherapy. Herein, we report a case of a 70-year-old man with diabetes mellitus and hypertension who received concurrent chemoradiation therapy after surgery for stage III pT3N1M0 rectal cancer. After completion of the therapy, the patient presented with a 2-week history of intermittent watery diarrhea (seven to nine times per day. However, the patient was afebrile and laboratory examination revealed no evidence of leukocytosis. Computed tomography disclosed inflammation of the sigmoid colon, infiltrative changes around the anastomotic site, and edematous changes straddling the serosal surface. Colonoscopic examination revealed multiple whitish patches within the radiation field, a finding suggestive of pseudomembranous colitis. No concomitant antibiotics were used during the period of concurrent chemoradiation therapy. Empirical oral metronidazole (500 mg every 8 hours was administrated for 2 weeks. At the end of this treatment, stool culture was negative for Clostridium difficile. Physicians should be aware of the potential for the development of

  15. The Effect of Higher Resolution and Improved Formulation of Surface Fluxes, Cloudiness, and Other Physical Parameters on a Simple Simulated Monsoon System

    Science.gov (United States)

    Fang, Lie-Shieu

    1985-12-01

    Many general circulation modelers have identified the key factors influencing the Indian southwest monsoon. Although the land-sea distribution and moist adiabatic processes are diagnosed as being the key factors in generating the monsoon, the interrelationship of these processes was not properly clarified so far by the existing models. In the following study the simple Webster and Chou model was employed to diagnose important monsoon events or disturbances such as the shock (suddenness of the monsoon burst), onset vortex, organized precipitation cells etc. and to resolve the near equatorial disturbances that develop on the Southern Equatorial Trough (SET). A two degree resolution in stead of the original four degree resolution was adopted in this study. A noteworthy result of the HR (High Resolution) experiment is the generation of a shock signalling the onset of monsoon. The results of CS (climatologically derived surface winds) case show a weakening of the shock but a stronger development of westerlies at 750 mb agreeing better with observation. The precipitation in association with the onset in CS is less compared to HR but is prolonged. The CA (climatologically derived albedos) experiment affected the timing of the monsoon onset, reduced the intensity of the shock and developed less rainfall than HR. A combination of the CS and CA experiments eliminated the shock, advanced the monsoon onset and increased the rainfall over the land area. The SET experiment demonstrates that SET can influence the monsoon activity by decreasing rainfall particularly north of 25(DEGREES)N. This means that SET can initiate break conditions over northern India. The land-sea boundary experiments dealing with the movement of the land-sea boundary from 10(DEGREES)N to 30(DEGREES)N show that the timing of the monsoon onset is thus dependent on the land-sea distribution while the vigor is dependent on the air-sea exchange.

  16. Fragilité des projets d’élevage familiaux dans les exploitations de polyculture-élevage au Burkina Faso

    Directory of Open Access Journals (Sweden)

    Delma Barkwendé Jéthro

    2016-01-01

    Full Text Available Dans les exploitations de polyculture-élevage du Burkina Faso, les producteurs ont des difficultés à mettre en œuvre des projets d’élevage familiaux (PEF qui répondent à leurs attentes en termes de revenus et de services. La présente étude vise à rechercher et à expliquer les causes de ces faiblesses. L’étude a été réalisée dans l’Ouest du Burkina Faso sur des PEF concernant des bovins. Elle a permis de montrer que tous les producteurs avaient des idées de PEF en tête. Un suivi a été réalisé sur des PEF de bovins de trait, de bovins à l’engraissement et de vaches laitières durant les étapes de conception puis d’exécution des PEF. Il en ressort que la majorité des PEF ont échoué avant même leur mise en œuvre, par manque de réalisme et de préparation. Ceux mis en place présentaient d’importantes faiblesses dans la maîtrise de l’alimentation, ce qui diminuait leur rentabilité. Ce diagnostic a permis d’établir les principes d’une démarche de conception pas à pas des PEF impliquant fortement le producteur, lui permettant de mieux calibrer et de mieux préparer le PEF, et de mieux gérer l’alimentation des animaux durant la mise en œuvre du PEF.

  17. Healing of Achilles tendon partial tear following focused shockwave: a case report and literature review

    Directory of Open Access Journals (Sweden)

    Hsu YC

    2017-05-01

    Full Text Available Yu-Chun Hsu,1,* Wei-Ting Wu,2,* Ke-Vin Chang,2–4 Der-Sheng Han,2–4 Li-Wei Chou5–7 1Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, 2Department of Physical Medicine and Rehabilitation and Community and Geriatric Research Center, National Taiwan University Hospital, Bei-Hu Branch, 3National Taiwan University College of Medicine, 4Community and Geriatric Research Center, National Taiwan University Hospital, Bei-Hu Branch, Taipei, 5Department of Physical Medicine and Rehabilitation, China Medical University Hospital, 6Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, 7Department of Rehabilitation, Asia University Hospital, Taichung, Taiwan *These authors contributed equally to this work Abstract: Achilles tendinopathy is a common cause of posterior heel pain and can progress to partial tendon tear without adequate treatment. Effects of traditional treatments vary, and many recent reports focus on the use of extracorporeal shockwave therapy (ESWT for Achilles tendinopathy but not for Achilles tendon partial tear. Here, we report the case of a 64-year-old female suffering from severe left heel pain for half a year. All treatment and rehabilitation were less effective until ESWT was applied. Each course of focused shockwave therapy included 2500 shots with energy flux density from 0.142 mJ/mm2 to 0.341 mJ/mm2. The visual analog scale decreased from nine to one degree. High-resolution musculoskeletal ultrasonography was performed before and 1 month after the treatment, which revealed healing of the torn region and decrease in inflammation. ESWT had shown to be an alternative treatment for Achilles tendon partial tear under safety procedure and ultrasound observation. Keywords: focused shockwave, Achilles tendon, partial tear, ultrasonography

  18. Prise en charge de l’infection gonococcique chez les adultes et les jeunes

    Science.gov (United States)

    Pogany, Lisa; Romanowski, Barbara; Robinson, Joan; Gale-Rowe, Margaret; Latham-Carmanico, Cathy; Weir, Christine; Wong, Tom

    2015-01-01

    Résumé Objectif Présenter des recommandations sur la prise en charge de l’infection gonococcique chez les adultes et les jeunes. Qualité des données Les recommandations thérapeutiques des lignes directrices canadiennes sur les infections transmissibles sexuellement reposent sur une recherche documentaire de même que sur des catégories de recommandations et des niveaux de qualité de données déterminés par au moins 2 évaluateurs. Les recommandations ont été revues par des pairs et sont en instance d’approbation par le groupe de travail d’experts. Message principal Les nouvelles recommandations portant sur la prise en charge de l’infection gonococcique chez les adultes et les jeunes préconisent les cultures à titre d’outil diagnostique lorsqu’elles sont pratiques, le traitement par antibiothérapie combinée (ceftriaxone associée à l’azithromycine) et le signalement sans délai de tous les cas dont le traitement a échoué aux autorités de santé publique. Conclusion Si elles sont suivies, ces nouvelles recommandations pourraient réduire l’échec thérapeutique, contribuer à une surveillance plus étroite des tendances à la résistance de Neisseria gonorrhoeae aux antibiotiques et contribuer à prévenir la transmission de gonorrhée résistante à plusieurs médicaments.

  19. Enantiomeric quantification of (S)-(+)-methamphetamine in urine by an immunoaffinity column and liquid chromatography-electrospray-mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lua, Ahai C. [Department of Laboratory Medicine and Biotechnology and Graduate Institute of Medical Biotechnology, Tzu Chi University, 701, Chung Yang Road Section 3, Hualien, 970, Taiwan (China); Sutono, Yenny [Department of Laboratory Medicine and Biotechnology and Graduate Institute of Medical Biotechnology, Tzu Chi University, 701, Chung Yang Road Section 3, Hualien, 970, Taiwan (China); Chou, T.-Y. [Department of Laboratory Medicine and Biotechnology and Graduate Institute of Medical Biotechnology, Tzu Chi University, 701, Chung Yang Road Section 3, Hualien, 970, Taiwan (China)]. E-mail: cty@mail.tcu.edu.tw

    2006-08-18

    A method using an immunoaffinity column (IAC) and liquid chromatography-electrospray ionization mass spectrometry (LC/MS) for on-line detecting the presence of MA in the effluent was developed for the quantitative and enantiomeric determination of (S)-(+)-methamphetamine (D-MA) in urine. The IAC was made in our laboratory and utilized in the LC/MS to simultaneously extract and separate enantiomers of MA from urine samples. An aqueous ammonium acetate buffer was used as the mobile phase. Urine samples were spiked with racemic deuterated methamphetamine (MA-d{sub 14}) as internal standard (IS), filtered through a membrane, and injected into the LC/MS without any further pre-treatment. Protonated molecular ion of MA and MA-d{sub 14} (m/z 150 and 164) were isolated and further fragmented, the respective product ions, m/z 119 and 130, were collected for quantitative determination. This is an improvement of our previous method (A.C. Lua, Tsong-Yung Chou, J. Chromatogr. A 967 (2002) 191). In the previous method, MA was separated with HPLC, the efflux was fractionated and each fraction was either determined with an immunoassay or GC/MS. Monitoring of MA in the efflux is tedious and time consuming. Urine samples spiked with different concentrations of D-MA were measured by this method. A linear relationship exists in the 150-1050 ng/mL range, and the detection limit (defined as signal-to-noise ratio 3) of D-MA was determined to be 18 ng/mL. The linearity of the method for D-MA can be described by the equation (Y = 1.415 x 10{sup -3} X + 0.034, correlation coefficient: r {sup 2} = 0.999). Within run, accuracy and precision (n = 6, relative error: -7.2 to +4.0% and relative standard deviation: 3.8-9.3%) of the method are fairly good.

  20. Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors.

    Science.gov (United States)

    Lomonosova, Elena; Zlotnick, Adam; Tavis, John E

    2017-03-01

    Combination therapies are standard for management of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections; however, no such therapies are established for human hepatitis B virus (HBV). Recently, we identified several promising inhibitors of HBV RNase H (here simply RNase H) activity that have significant activity against viral replication in vitro Here, we investigated the in vitro antiviral efficacy of combinations of two RNase H inhibitors with the current anti-HBV drug nucleoside analog lamivudine, with HAP12, an experimental core protein allosteric modulator, and with each other. Anti-HBV activities of the compounds were tested in a HepG2-derived cell line by monitoring intracellular core particle DNA levels, and cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. The antiviral efficiencies of the drug combinations were evaluated using the median-effect equation derived from the mass-action law principle and combination index theorem of Chou and Talalay. We found that combinations of two RNase H inhibitors from different chemical classes were synergistic with lamivudine against HBV DNA synthesis. Significant synergism was also observed for the combination of the two RNase H inhibitors. Combinations of RNase H inhibitors with HAP12 had additive antiviral effects. Enhanced cytotoxicity was not observed in the combination experiments. Because of these synergistic and additive effects, the antiviral activity of combinations of RNase H inhibitors with drugs that act by two different mechanisms and with each other can be achieved by administering the compounds in combination at doses below the respective single drug doses. Copyright © 2017 American Society for Microbiology.

  1. Antiphospholipid syndrome presenting as progressive neuropsychiatric disorders: two case reports

    Directory of Open Access Journals (Sweden)

    Li CH

    2013-05-01

    Full Text Available Chien-Hsun Li,1–3 Mei-Chuan Chou,2,4 Ching-Kuan Liu,2,3 Chiou-Lian Lai2,31Department of Neurology, Fooyin University Hospital, Pingtung, Taiwan; 2Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 3Department of and Master’s Program in Neurology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 4Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, TaiwanAbstract: The antiphospholipid syndrome (APS is a rare form of autoimmune coagulopathy. In this syndrome, the most common neurologic abnormality is transient ischemic attack. This can be easily overlooked if a patient presents with progressive neuropsychiatric disorders, such as depression or dementia. We report two cases of young women, aged 35 and 22 years, presenting with progressive depression and mental decline over a certain period. The neuropsychological diagnoses of the two patients were, respectively, dementia with disinhibition and borderline dementia with depression. Brain magnetic resonance imaging showed multiple old infarcts with encephalomalacia in the former case, and only one cortical hemorrhagic infarction, over the right temporoparietal lobe, observed in the latter case. The outcomes of the two cases were also very different. Progressive neuropsychiatric disorders are increasingly observed in the young; therefore, APS and other autoimmune diseases should be considered during the differential diagnosis. Brain imaging examinations may prevent a delay in the detection of a structural lesion and facilitate the early intervention with good prognosis. Careful investigations by experts from different disciplines are always encouraged in complicated cases.Keywords: autoimmune disease, brain imaging, dementia, depression, cerebrovascular disease

  2. Quelle « perspective » entre Moscou et Saint-Pétersbourg ?

    Directory of Open Access Journals (Sweden)

    Dimitri Issaev

    2008-02-01

    Full Text Available La coexistence de deux capitales dans un même pays, même si elles se répartissent historiquement les périodes d’activité en tant que telles, entraîne des tensions et des rivalités qui ont des répercussions sur l’aménagement du territoire. Aujourd’hui, le gouvernement russe a lancé le projet hautement symbolique d’une autoroute reliant directement Moscou et Saint-Pétersbourg. Mais ce projet n’est pas nouveau : Pierre le Grand, en fondant Saint-Pétersbourg, l’avait déjà formulé. Qu’en est-il advenu ? Pourquoi, trois siècles plus tard, cette route est-elle toujours à l’état de projet ? Il existe des documents qui indiquent que l’effort de construction a été entreprise : textes officiels, cartes, témoignages, etc. L’objet de cet article est d’essayer de faire le point sur ce que l’on peut véritablement connaître de ce projet de Pierre le Grand : jusqu’où et jusqu’à quand a-t-il été mené ? Pourquoi a-t-il échoué, et quelles leçons le projet en cours peut-il en tirer ?

  3. Dual drug-loaded biofunctionalized amphiphilic chitosan nanoparticles: Enhanced synergy between cisplatin and demethoxycurcumin against multidrug-resistant stem-like lung cancer cells.

    Science.gov (United States)

    Huang, Wei-Ting; Larsson, Mikael; Lee, Yi-Chi; Liu, Dean-Mo; Chiou, Guang-Yuh

    2016-12-01

    Lung cancer kills more humans than any other cancer and multidrug resistance (MDR) in cancer stem-like cells (CSC) is emerging as a reason for failed treatments. One concept that addresses this root cause of treatment failure is the utilization of nanoparticles to simultaneously deliver dual drugs to cancer cells with synergistic performance, easy to envision - hard to achieve. (1) It is challenging to simultaneously load drugs of highly different physicochemical properties into one nanoparticle, (2) release kinetics may differ between drugs and (3) general requirements for biomedical nanoparticles apply. Here self-assembled nanoparticles of amphiphilic carboxymethyl-hexanoyl chitosan (CHC) were shown to present nano-microenvironments enabling simultaneous loading of hydrophilic and hydrophobic drugs. This was expanded into a dual-drug nano-delivery system to treat lung CSC. CHC nanoparticles were loaded/chemically modified with the anticancer drug cisplatin and the MDR-suppressing Chinese herbal extract demethoxycurcumin, followed by biofunctionalization with CD133 antibody for enhanced uptake by lung CSC, all in a feasible one-pot preparation. The nanoparticles were characterized with regard to chemistry, size, zeta potential and drug loading/release. Biofunctionalized and non-functionalized nanoparticles were investigated for uptake by lung CSC. Subsequently the cytotoxicity of single and dual drugs, free in solution or in nanoparticles, was evaluated against lung CSC at different doses. From the dose response at different concentrations the degree of synergy was determined through Chou-Talalay's Plot. The biofunctionalized nanoparticles promoted synergistic effects between the drugs and were highly effective against MDR lung CSC. The efficacy and feasible one-pot preparation suggests preclinical studies using relevant disease models to be justified. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/AKT signaling pathway

    Science.gov (United States)

    Zheng, Yuan-ting; Yang, Hui-ying; Li, Tao; Zhao, Bei; Shao, Teng-fei; Xiang, Xiao-qiang; Cai, Wei-min

    2015-01-01

    Aim: Blockade of EGFR by EGFR tyrosine kinase inhibitors such as erlotinib is insufficient for effective treatment of human pancreatic cancer due to independent activation of the Akt pathway, while amiloride, a potassium-sparing diuretic, has been found as a potential Akt inhibitor. The aim of this study was to investigate the anticancer effects of combined amiloride with erlotinib against human pancreatic cancer cells in vitro. Methods: Cell proliferation, colony formation, cell cycle and apoptosis were analyzed in 4 human pancreatic cancer cell lines Bxpc-3, PANC-1, Aspc-1 and CFPAC-1 treated with erlotinib or amiloride alone, or in their combination. The synergistic analysis for the effects of combinations of amiloride and erlotinib was performed using Chou-Talalay's combination index isobolographic method. Results: Amiloride (10, 30, and 100 μmol/L) concentration-dependently potentiated erlotinib-induced inhibition of cell proliferation and colony formation in the 4 pancreatic cancer cell lines. Isobolographic analysis confirmed that combinations of amiloride and erlotinib produced synergistic cytotoxic effects. Amiloride significantly potentiated erlotinib-induced G0/G1 cell-cycle arrest and apoptosis in Bxpc-3 and PANC-1 cells. Amiloride inhibited EGF-stimulated phorsphorylation of AKT, and significantly enhanced erlotinib-induced downregulation of phorsphorylation of EGFR, AKT, PI3K P85 and GSK 3β in Bxpc-3 and PANC-1 cells. Conclusion: Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/AKT signaling pathway. Treatment of pancreatic cancer patients with combination of erlotinib and amiloride merits further investigation. PMID:25864651

  5. Simultaneous silencing of ACSL4 and induction of GADD45B in hepatocellular carcinoma cells amplifies the synergistic therapeutic effect of aspirin and sorafenib.

    Science.gov (United States)

    Xia, Hongping; Lee, Kee Wah; Chen, Jianxiang; Kong, Shik Nie; Sekar, Karthik; Deivasigamani, Amudha; Seshachalam, Veerabrahma Pratap; Goh, Brian Kim Poh; Ooi, London Lucien; Hui, Kam M

    2017-01-01

    Sorafenib is currently the only US Food and Drug Administration (FDA)-approved molecular inhibitor for the systemic therapy of advanced hepatocellular carcinoma (HCC). Aspirin has been studied extensively as an anti-inflammation, cancer preventive and therapeutic agent. However, the potential synergistic therapeutic effects of sorafenib and aspirin on advanced HCC treatment have not been well studied. Drug combination studies and their synergy quantification were performed using the combination index method of Chou-Talalay. The synergistic therapeutic effects of sorafenib and aspirin were evaluated using an orthotopic mouse model of HCC and comprehensive gene profiling analyses were conducted to identify key factors mediating the synergistic therapeutic effects of sorafenib and aspirin. Sorafenib was determined to act synergistically on HCC cells with aspirin in vitro. Using Hep3B and HuH7 HCC cells, it was demonstrated that sorafenib and aspirin acted synergistically to induce apoptosis. Mechanistic studies demonstrated that combining sorafenib and aspirin yielded significant synergistically anti-tumor effects by simultaneously silencing ACSL4 and the induction of GADD45B expression in HCC cells both in vitro and in the orthotopic HCC xenograft mouse model. Importantly, clinical evidence has independently corroborated that survival of HCC patients expressing ACSL4(high)GADD45B(low) was significantly poorer compared to patients with ACSL4(low)GADD45B(high), thus demonstrating the potential clinical value of combining aspirin and sorafenib for HCC patients expressing ACSL4(high)GADD45B(low). In conclusion, sorafenib and aspirin provide synergistic therapeutic effects on HCC cells that are achieved through simultaneous silencing of ACSL4 and induction of GADD45B expression. Targeting HCC with ACSL4(high)GADD45B(low) expression with aspirin and sorafenib could provide potential synergistic therapeutic benefits.

  6. A comparison of complex sleep behaviors with two short-acting Z-hypnosedative drugs in nonpsychotic patients

    Directory of Open Access Journals (Sweden)

    Chen LF

    2013-08-01

    Full Text Available Li-Fen Chen,1 Ching-En Lin,1–3 Yu-Ching Chou,4 Wei-Chung Mao,1,5 Yi-Chyan Chen,1–3 Nian-Sheng Tzeng1,6 1Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City, Taiwan; 2Taipei Tzu Chi Hospital, The Buddhist Medical Foundation, Taipei, Taiwan; 3School of Medicine, Tzu Chi University, Hualien, Taiwan; 4School of Public Health, National Defense Medical Center, Taipei City, Taiwan; 5Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei City, Taiwan; 6Student Counseling Center, National Defense Medical Center, Taipei City, Taiwan Objective: Complex sleep behaviors (CSBs are classified as “parasomnias” in the International Classification of Sleep Disorders, Second Edition (ICSD-2. To realize the potential danger after taking two short-acting Z-hypnosedative drugs, we estimated the incidence of CSBs in nonpsychotic patients in Taiwan. Methods: Subjects (N = 1,220 using zolpidem or zopiclone were enrolled from the psychiatric outpatient clinics of a medical center in Taiwan over a 16-month period in 2006–2007. Subjects with zolpidem (N = 1,132 and subjects with zopiclone (N = 88 were analyzed. All subjects completed a questionnaire that included demographic data and complex sleep behaviors after taking hypnotics. Results: Among zolpidem and zopiclone users, 3.28% of patients reported incidents of somnambulism or amnesic sleep-related behavior problems. The incidence of CSBs with zolpidem and zopiclone were 3.27%, and 3.41%, respectively, which was significantly lower than other studies in Taiwan. Conclusion: These results serve as a reminder for clinicians to make inquiries regarding any unusual performance of parasomnic activities when prescribing zolpidem or zopiclone. Keywords: parasomnia, somnambulism, amnesic sleep-related behavior, sleepwalking, zolpidem, zopiclone

  7. Effectiveness of sensory processing strategies on activity level in inclusive preschool classrooms

    Directory of Open Access Journals (Sweden)

    Lin CL

    2012-10-01

    Full Text Available Chien-Lin Lin,1,2 Yu-Fan Min,3 Li-Wei Chou,1,2,* Chin-Kai Lin,4,* 1Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 2School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 3Faith, Hope and Love, Center for Children and Adults With Disabilities, Taichung, Taiwan; 4Program of Early Intervention, Department of Early Childhood Education, National Taichung University of Education, Taichung, Taiwan*These authors contributed equally to this workBackground: The purpose of this study was to investigate the effectiveness of sensory processing strategies in improving the activity level of children with sensory integration dysfunction.Methods: The study used a matching-only pretest–posttest control group design, which requires random matching of sensory integration dysfunction to the corresponding intervention group (n = 18 and control group (n = 18. The intervention group comprised 3–6-year-old children who received an 8-week school-day intervention during implementation of the theme curriculum.Results: The 8-week treatment significantly reduced the activity level and foot-swinging episodes in children with sensory integration dysfunction, and obtained a medium-effect size. However, the level of improvement in the control group did not show any statistically significant change.Conclusion: Sensory processing strategies could improve activity levels in children with sensory integration dysfunction. However, this study was unable to exclude a developmental effect. The social validity results show that sensory processing strategies can be integrated into the theme curriculum and improve activity levels in children.Keywords: activity level, preschool inclusive classroom, sensory integration dysfunction, sensory processing strategy

  8. In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other novel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line.

    Science.gov (United States)

    Kanzawa, F; Akiyama, Y; Saijo, N; Nishio, K

    2003-06-01

    Among numerous clinical regimens of combination chemotherapy, synergy has been observed to be particularly marked with combinations containing cisplatin (CDDP). However, the clinical use of CDDP has sometimes been limited by acquired resistance. The new-generation platinum drug, ZD0473, was synthesized with the aim of hindering the reaction of the drug with thiols, by the introduction of a 2-methylpyridine ligand. This enables the drug to exert antitumor activity against cisplatin-resistant cancer cells with elevated glutathione and/or metallothionein levels. The drug was also shown experimentally to overcome cisplatin resistance due to impaired drug accumulation, and enhanced DNA repair/tolerance to platinum-DNA adducts. We investigated the effects of combinations of ZD0473 with other anticancer drugs on the growth of a human small-cell lung cancer cell line (SBC-3). Six novel anticancer drugs were tested: docetaxel (TXT), paclitaxel (TXL), vinorelbine (VNB), irinotecan (CPT-11), gemcitabine (GEM) and pemetrexed (MTA). The growth inhibitory effect of the drugs was measured by MTT assay and the effects of the combination regimens were evaluated by the combination index analysis method developed by Chou and Talalay. Synergy was demonstrated for the combination regimens of ZD0473-GEM and ZD0473-TXL, while an additive effect was observed with combinations containing TXT, VNB, CPT-11 or MTA. In the case of the ZD0473-GEM combination, synergy was observed over a wide range of inhibition levels at dose ratios of 50:1, 100:1 and 250:1. The level of synergy was equivalent to that observed for combinations of CDDP-etoposide, CDDP-GEM and nedaplatin-CPT-11. The results suggest that the combination of ZD0473 with GEM merits further investigation in small cell lung cancer.

  9. Nuc-PLoc: a new web-server for predicting protein subnuclear localization by fusing PseAA composition and PsePSSM.

    Science.gov (United States)

    Shen, Hong-Bin; Chou, Kuo-Chen

    2007-11-01

    The life processes of an eukaryotic cell are guided by its nucleus. In addition to the genetic material, the cellular nucleus contains many proteins located at its different compartments, called subnuclear locations. Information of their localization in a nucleus is indispensable for the in-depth study of system biology because, in addition to helping determine their functions, it can provide illuminative insights of how and in what kind of microenvironments these subnuclear proteins are interacting with each other and with other molecules. Facing the deluge of protein sequences generated in the post-genomic age, we are challenged to develop an automated method for fast and effectively annotating the subnuclear locations of numerous newly found nuclear protein sequences. In view of this, a new classifier, called Nuc-PLoc, has been developed that can be used to identify nuclear proteins among the following nine subnuclear locations: (1) chromatin, (2) heterochromatin, (3) nuclear envelope, (4) nuclear matrix, (5) nuclear pore complex, (6) nuclear speckle, (7) nucleolus, (8) nucleoplasm and (9) nuclear promyelocytic leukaemia (PML) body. Nuc-PLoc is featured by an ensemble classifier formed by fusing the evolution information of a protein and its pseudo-amino acid composition. The overall jackknife cross-validation accuracy obtained by Nuc-PLoc is significantly higher than those by the existing methods on the same benchmark data set through the same testing procedure. As a user-friendly web-server, Nuc-PLoc is freely accessible to the public at http://chou.med.harvard.edu/bioinf/Nuc-PLoc.

  10. Alexa Irene Canady: the first African-American woman neurosurgeon.

    Science.gov (United States)

    McClelland, Shearwood

    2008-04-01

    The advances of the civil rights movement in the mid-20th century made it possible for many African Americans to have the opportunity to enter the distinguished field of neurosurgery, beginning in 1953 with Clarence S. Greene, Sr. This report details the career and exploits of the first African-American woman neurosurgeon, Alexa Irene Canady, MD. A comprehensive review of pertinent modern and historical records spanning the past century was performed. Born on November 7, 1950, in Lansing, MI, Canady received her MD from the University of Michigan in 1975, graduating with distinction and being elected into the Alpha Omega Alpha Honor Society. Training in neurosurgery under Dr. Shelley Chou from 1976-1981 at the University of Minnesota, she became the program's first female graduate. Following residency, she trained as a pediatric neurosurgery fellow at the Children's Hospital of Philadelphia. In 1984, Canady became the first African-American woman certified by the American Board of Neurological Surgery. She subsequently continued a long, distinguished career in pediatric neurosurgery, first at Henry Ford and later as chief of neurosurgery at Children's Hospital of Michigan before retiring in 2001. Among her many accolades, she was named 1993 Woman of the Year by the American Woman's Medical Association. Canady's diligence, perseverance and commitment enabled her to overcome tremendous odds to become the first African-American woman neurosurgeon, trained at the University of Minnesota. A true pioneer, her achievements have inspired many, opening the door for subsequent women and African Americans to enhance the field of neurosurgery.

  11. Performance of Goddard earth observing system GCM column radiation models under heterogeneous cloud conditions

    Science.gov (United States)

    Oreopoulos, L.; Chou, M.-D.; Khairoutdinov, M.; Barker, H. W.; Cahalan, R. F.

    2004-11-01

    We test the performance of the shortwave (SW) and longwave (LW) Column Radiation Models (CORAMs) of Chou and collaborators with heterogeneous cloud fields from a single-day global dataset produced by NCAR's Community Atmospheric Model (CAM) with a 2-D Cloud Resolving Model (CRM) installed in each column. The original SW version of the CORAM performs quite well compared to reference Independent Column Approximation (ICA) calculations for boundary fluxes (global error ˜4 W m -2 for reflected flux), largely due to the success of a combined overlap and cloud scaling parameterization scheme. The absolute magnitude of errors relative to ICA are even smaller (global error ˜2 W m -2 for outgoing flux) for the LW CORAM which applies similar overlap. The vertical distribution of heating and cooling within the atmosphere is also simulated quite well with daily averaged zonal errors always less than 0.3 K/day for SW and 0.6 K/day for LW heating (cooling) rates. The SW CORAM's performance improves by introducing a scheme that accounts for cloud inhomogeneity based on the Gamma Weighted Two Stream Approximation (GWTSA). These results suggest that previous studies demonstrating the inaccuracy of plane-parallel models may have unfairly focused on worst case scenarios, and that current radiative transfer algorithms in General Circulation Models (GCMs) may be more capable than previously thought in estimating realistic spatial and temporal averages of radiative fluxes, as long as they are provided with correct mean cloud profiles. However, even if the errors of our particular CORAMs are small, they seem to be systematic, and their impact can be fully assessed only with GCM climate simulations.

  12. Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents:Doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells

    Institute of Scientific and Technical Information of China (English)

    Khosit Pinmai; Sriharut Chunlaratthanabhorn; Chatri Ngamkitidechakul; Noppamas Soonthornchareon; Chariya Hahnvajanawong

    2008-01-01

    AIM:To examine the growth inhibitory effects of Phyllanthus emblica (P.emblica) and Terminalia belierica (T.bellerica) extracts on human hepatocellular carcinoma (HepG2),and lung carcinoma (A549) cells and their synergistic effect with doxorubicin or cisplatin.METHODS:HepG2 and A549 cells were treated with P.ernblica and T.bellerica extracts either alone or in combination with doxorubicin or cisplatin and effects on cell growth were determined using the sulforhodamine B (SRB) assay.The isobologram and combination index (CI) method of Chou-Talalay were used to evaluate interactions between plant extracts and drugs.RESULTS:P.ernblica and T.bellerica extracts demonstrated growth inhibitory activity,with a certain degree of selectivity against the two cancer cell linestested.Synergistic effects (CI<1) for P.emblica/doxorubicin or cisplatin at different dose levels weredemonstrated in A549 and HepG2 cells.The T.bellerica/cisplatin or doxorubicin also showed synergistic effects in A549 and HepG2 cells.In some instances,the combinations resulted in antagonistic effects.The dose reduction level was different and specific to each combination and cell line.CONCLUSION:The growth inhibitory activity of doxorubicin or cisplatin,as a single agent,may be modified by combinations of P.emblica or T.bellerica extracts and be synergistically enhanced in some cases.Depending on the combination ratio,the doses for each drug for a given degree of effect in the combination may be reduced.The mechanisms involved in this interaction between chemotherapeutic drugs and plant extracts remain unclear and should be further evaluated.

  13. Computational uncertainty principle in nonlinear ordinary differential equations

    Institute of Scientific and Technical Information of China (English)

    LI; Jianping

    2001-01-01

    [1]Li Jianping, Zeng Qingcun, Chou Jifan, Computational Uncertainty Principle in Nonlinear Ordinary Differential Equations I. Numerical Results, Science in China, Ser. E, 2000, 43(5): 449[2]Henrici, P., Discrete Variable Methods in Ordinary Differential Equations, New York: John Wiley, 1962, 1; 187.[3]Henrici, P., Error Propagation for Difference Methods, New York: John Whiley, 1963.[4]Gear, C. W., Numerical Initial Value Problems in Ordinary Differential Equations, Englewood Cliffs, NJ: Prentice-Hall, 1971, 1; 72.[5]Hairer, E., Nrsett, S. P., Wanner, G., Solving Ordinary Differential Equations I. Nonstiff Problems, 2nd ed., Berlin-Heidelberg-New York: Springer-Verlag, 1993, 130.[6]Stoer, J., Bulirsch, R., Introduction to Numerical Analysis, 2nd ed., Vol. 1, Berlin-Heidelberg-New York: Springer-Verlag (reprinted in China by Beijing Wold Publishing Corporation), 1998, 428.[7]Li Qingyang, Numerical Methods in Ordinary Differential Equations (Stiff Problems and Boundary Value Problems), in Chinese Beijing: Higher Education Press, 1991, 1.[8]Li Ronghua, Weng Guochen, Numerical Methods in Differential Equations (in Chinese), 3rd ed., Beijing: Higher Education Press, 1996, 1.[9]Dahlquist, G., Convergence and stability in the numerical integration of ordinary differential equations, Math. Scandinavica, 1956, 4: 33.[10]Dahlquist, G., 33 years of numerical instability, Part I, BIT, 1985, 25: 188.[11]Heisenberg, W., The Physical Principles of Quantum Theory, Chicago: University of Chicago Press, 1930.[12]McMurry, S. M., Quantum Mechanics, London: Addison-Wesley Longman Ltd (reprined in China by Beijing World Publishing Corporation), 1998.

  14. Polysaccharide from Sepia esculenta ink and cisplatin inhibit synergistically proliferation and metastasis of triple-negative breast cancer MDA-MB-231 cells

    Directory of Open Access Journals (Sweden)

    Hua-Zhong Liu

    2016-12-01

    Full Text Available Objective(s: This paper aims to investigate synergistic inhibition of polysaccharide from Sepia esculenta ink (SIP, a newly isolated marine polysaccharide in our laboratory, on breast cancer MDA-MB-231 cells exposed to cisplatin. Materials and Methods: Cell viability of MDA-MB-231 cells was determined by CCK 8 assay. Median-effect concentration was analyzed using Chou-Talalay method that was also subjected to determine cell inhibition ratio and combined index, as well as interaction between SIP and cisplatin. Proliferation and migration abilities were detected with plate colony formation assay and cell wound scratch assay, respectively. Expression of MMP-2 and MMP-9 proteins was measured with Western blot assay. Results: Data showed that SIP not only suppressed proliferation and migration of MDA-MB-231 cells, and expression of MMP-2 and MMP-9 proteins, also promoted inhibition of cisplatin on proliferation, migration and MMPs expression of MDA-MB-231 cells, which indicates synergy inhibition of drug combination of SIP and cisplatin on breast cancer cells. The median-effect concentrations of cisplatin and SIP were 4.9 and 1659.6 μg/ml, respectively. Whereas the concentration of combination drug was 158.5 μg/ml. The data indicated that drug combination can decrease dosages of the two single agents, especially the usual dosage of cisplatin. Conclusion: This research demonstrated that SIP repressed proliferation and metastasis of MDA-MB-231 cells and promoted anticancer effect of cisplatin on the breast cancer cells. The data suggested that SIP is a potential natural drug that can be used as an auxiliary medicine alongside chemotherapy in treating breast cancer.

  15. ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Eun Young Kim

    2017-04-01

    Full Text Available A subset of non-small cell lung cancer (NSCLC, which does not have a druggable driver mutation, is treated with platinum-based cytotoxic chemotherapy, but it develops resistance triggered by DNA damage responses. Here, we investigated the effect of activation of STAT3 by cisplatin on anti-apoptotic proteins and the effectiveness of a co-treatment with cisplatin and a BH3 mimetic, ABT-737. We analyzed the relationship between cisplatin and STAT3 pathway and effect of ABT-737, when combined with cisplatin in NSCLC cells and K-ras mutant mouse models. The synergism of this combination was evaluated by the Chou-Talalay Combination Index method. In vivo activity was evaluated by micro-CT. In NSCLC cells, there was a time and dose-dependent phosphorylation of SRC-JAK2-STAT3 by cisplatin, followed by increased expression of anti-apoptotic molecules. When the expression of the BCL-2 protein family members was evaluated in clinical samples, BCL-xL was most frequently overexpressed. Dominant negative STAT3 suppressed their expression, suggesting that STAT3 mediates cisplatin mediated overexpression of the anti-apoptotic molecules. ABT-737 displaced BCL-xL from mitochondria and induced oligomerization of BAK. ABT-737 itself showed cytotoxic effects and a combination of ABT-737 with cisplatin showed strong synergistic cytotoxicity. In a murine lung cancer model, co-treatment with ABT-737 and cisplatin induced significant tumor regression. These findings reveal a synergistic cytotoxic and anti-tumor activity of ABT-737 and cisplatin co-treatment in preclinical models, and suggest that clinical trials using this strategy may be beneficial in advanced NSCLC.

  16. MemType-2L: a web server for predicting membrane proteins and their types by incorporating evolution information through Pse-PSSM.

    Science.gov (United States)

    Chou, Kuo-Chen; Shen, Hong-Bin

    2007-08-24

    Given an uncharacterized protein sequence, how can we identify whether it is a membrane protein or not? If it is, which membrane protein type it belongs to? These questions are important because they are closely relevant to the biological function of the query protein and to its interaction process with other molecules in a biological system. Particularly, with the avalanche of protein sequences generated in the Post-Genomic Age and the relatively much slower progress in using biochemical experiments to determine their functions, it is highly desired to develop an automated method that can be used to help address these questions. In this study, a 2-layer predictor, called MemType-2L, has been developed: the 1st layer prediction engine is to identify a query protein as membrane or non-membrane; if it is a membrane protein, the process will be automatically continued with the 2nd-layer prediction engine to further identify its type among the following eight categories: (1) type I, (2) type II, (3) type III, (4) type IV, (5) multipass, (6) lipid-chain-anchored, (7) GPI-anchored, and (8) peripheral. MemType-2L is featured by incorporating the evolution information through representing the protein samples with the Pse-PSSM (Pseudo Position-Specific Score Matrix) vectors, and by containing an ensemble classifier formed by fusing many powerful individual OET-KNN (Optimized Evidence-Theoretic K-Nearest Neighbor) classifiers. The success rates obtained by MemType-2L on a new-constructed stringent dataset by both the jackknife test and the independent dataset test are quite high, indicating that MemType-2L may become a very useful high throughput tool. As a Web server, MemType-2L is freely accessible to the public at http://chou.med.harvard.edu/bioinf/MemType.

  17. Nucleoplasty for treating lumbar disk degenerative low back pain: an outcome prediction analysis

    Directory of Open Access Journals (Sweden)

    Liliang PC

    2016-10-01

    Full Text Available Po-Chou Liliang,1 Kang Lu,1 Cheng-Loong Liang,1 Ya-Wen Chen,2,3 Yu-Duan Tsai,1 Yuan-Kun Tu4 1Department of Neurosurgery, E-Da Hospital, 2Department of Nursing, I-Shou University, 3School of Nursing, Kaohsiung Medical University, 4Department of Orthopedic Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan Purpose: Nucleoplasty is a minimally invasive technique that is considered efficacious in alleviating lumbar disk degenerative low back pain (LBP. The efficacy of nucleoplasty and identified variables that can predict pain relief for nucleoplasty was reported. Patients and methods: Between December 2013 and November 2015, 47 nucleoplasty procedures on 47 lumbar disks in 31 consecutive patients were performed. The outcome was evaluated using a visual analog scale (VAS score. Improvements of ≥50% in VAS scores were considered substantial pain relief. The variables associated with pain relief after nucleoplasty included: 1 age; 2 sex; 3 body mass index; 4 hyperintensity zone at the rear of the disk; 5 hypointensity of the disk; 6 Modic changes of the end plates; 7 spinal instability pain; and 8 discography results. Results: Twenty-one patients (67.7% experienced substantial pain relief. The most common side effects following nucleoplasty were soreness at the needle puncture site (64.5%, numbness in the lower leg (12.9%, and increased intensity of back pain (9.7%. All side effects were transient. Multivariate analysis revealed that the discography results were the most critical predictor for substantial pain relief of nucleoplasty (P=0.03. The sensitivity and specificity of discography were 92.8% and 62.5%, respectively. Conclusion: Discography results could improve the success rate of nucleoplasty in the treatment of disk degenerative LBP. Keywords: low back pain, lumbar disk degenerative, nucleoplasty, discography 

  18. Prediction of the secondary structure and B cell epitope for the E protein of SARS coronavirus%SARS病毒基因组所编码的E蛋白的二级结构和B细胞表位预测

    Institute of Scientific and Technical Information of China (English)

    吕燕波; 万瑛; 吴玉章

    2003-01-01

    目的预测SARS病毒E蛋白的B细胞表位和二级结构.方法以SARS病毒基因组序列为基础,采用Gar-nier-Robson方法、Chou-Fasman方法和Karplus-Schultz方法预测E蛋白质的二级结构;用Kyte-Doolittle方案预测蛋白质的亲水性;用Emini方案预测蛋白质的表面可能性;用Jmeson-Wolf方案预测氨基酸的抗原性指数.综合评判,预测SARS病毒E蛋白的B细胞表位.结果在SARS病毒E蛋白N-端的第1~6、13~19、39~43、47~64区段和第73~76区段有β-折叠中心;第6~12区段和第67~69区段可能形成转角或无规则卷曲,是柔性区域.E蛋白N端第2~13区段和第61~74区段为B细胞优势表位区域.结论用多参数预测SARS病毒E蛋白的二级结构和B细胞表位,为实验方法探索SARS冠状病毒E蛋白的B细胞表位提供理论依据.

  19. Conformational origin of a difficult coupling in a human growth hormone releasing factor analog.

    Science.gov (United States)

    Deber, C M; Lutek, M K; Heimer, E P; Felix, A M

    1989-01-01

    During the solid-phase synthesis of the human growth hormone releasing factor (GRF) analog [Ala15, Leu27, Asn28] -GRF(1-32)-OH, incorporation of Boc-Gln16 was determined to be incomplete. While aggregation of growing resin-bound peptide chains with concomitant beta-sheet formation and "precipitation" has been proposed to account in general for such "difficult coupling," no feature of sequence in the Gln16 region of this GRF analog provided an immediate rationale for this result. We now report 500 MHz 1H NMR spectra of a series of resin-bound GRF segments surrounding the Gln16 position (19-32 through 14-32), swelled in dimethylsulfoxide-d6 solutions [GRF(14-32) = Leu14-Ala-Gln-Leu-Ser(Bzl)-Ala-Arg(Tos)-Lys(CIZ)-Leu- Leu-Gln-Asp(OcHex)-Ile-Leu-Asn-Arg(Tos)-Gln-Gln-Gly32-PAM resin]. While relatively sharp spectra are observed for GRF(19-32), components with resonances broadened by an order-of-magnitude appear in spectra of the 18-32 and 17-32 peptide-resin, and the entire spectrum of 16-32 is ill-resolved and highly broadened. Subsequent spectra sharpen again (15-32, 14-32). These combined synthesis/spectroscopic experimental results, in conjunction with predictive analyses using standard Chou-Fasman 2 degrees structure parameters, suggest that the completeness of the Gln16 coupling is hindered by formation of a specific, folded beta-sheet/beta-turn structure in GRF(16-32) (with the turn located at 18-21, "upstream" of the difficult coupling site), and accompanying aggregation of peptide chains. This analysis suggests that awareness of such potential beta-sheet/beta-turn sequences can guide analog choices, and/or facilitate pre-programming of synthesis steps in anticipation of problem couplings.

  20. 由"天"之意涵论儒家思想的宗教性%The Religious Character of Confucianism Meanings of Tian

    Institute of Scientific and Technical Information of China (English)

    贾继让

    2009-01-01

    In the thoughts of our ancestors, Tian had both of the natural and religious meanings.Howevr,after the Chou Dynasty, with the awakening of humanistic spirit,the two meanings of Tian increasingly separated.On the one hand ,the natural meaning emerged obviously and separated fron huaman beings; but more importantly, the religious meaning of Tian switched to the root of morality and therefore had the ontological meaning, but it still the ultimate linked with the the ultimate care for human beings and moral cultivation closely . Therefore, in comparison with the tradition of Western rationalism, we may discover that has both the religious and philosophical character.%在先民的思想世界中,"天"兼具自然性与宗教性,但是在周以后,随着人文精神的觉醒,"天"的这两种性质逐渐分离开来,一方面是其自然性凸现出来而与人相分离;但更重要的是"天"的宗教性的意涵转化成为人的道德的根源,因而具有了本体论的意味,但它与人的终极关怀和功夫修养仍然紧密联系.因此,通过与西方理性主义思想传统的比较,我们可以发现儒学同时具有宗教性与哲学性的特质.

  1. A Comparison of the Aesthetic Ideas between Chuang Chou’s Butterfly Dream and Ode to a Nightingale%比较《庄周梦蝶》和《夜莺颂》的美学思想

    Institute of Scientific and Technical Information of China (English)

    柯亚

    2015-01-01

    Chuang Chou’s Butterfly Dream is the masterpiece of Chinese great thinker Chuang Chou, while Ode to a Nightingale is the masterpieces of English Romantic poet Keats. Although they came from different cultural backgrounds, they signed similar⁃ly with emotion at different time. This paper attempts to explore the differences and similarities of the Aesthetic Ideas between the two famous works through three perspectives—reflections of beauty, theories, and images they used.%庄子和济慈分别作为伟大的思想家和诗人分别对中国和西方的文学发展作出了突出的贡献,《庄周梦蝶》和《夜莺颂》是他们的代表作。他们尽管来自不同的文化背景,却在不同的时空里发出了相似的感叹。该文将从对美的见解,作者本身的理论思想,作品中蕴含的感情以及他们所用的意象这四个方面对这两部作品进行美学思想的比较,进而分析两者的相似和不同。本文旨在通过多个角度更好地理解这两部作品的内涵,并对其它相关性的研究起到补充性说明的作用。

  2. Omega-3 Polyunsaturated Fatty Acids Enhance Cisplatin Efficacy in Gastric Cancer Cells by Inducing Apoptosis via ADORA1.

    Science.gov (United States)

    Sheng, Hong; Chen, Xuehua; Liu, Binya; Li, Pu; Cao, Weixin

    2016-01-01

    It has been suggested that administration of the omega-3 polyunsaturated fatty acids (ω-3 PUFAs), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), can alter the toxicity and/or activity of several anticancer drugs in in vitro and in vivo studies. Here, we investigated the ability of ω-3 PUFAs to potentiate the antineoplastic activity of cisplatin (CDDP) in gastric cancer cells. The increase in CDDP-induced growth inhibition was measured by the IC50 values obtained when the cells were incubated with CDDP alone or with CDDP plus DHA or EPA. DHA and EPA enhanced the growth-inhibition activity of increasing concentrations of CDDP. The interactions between CDDP and DHA or EPA at the cellular level were assessed through the combination index (CI) method of Chou-Talalay. The results demonstrated synergism between CDDP and DHA or EPA in MKN45 cells. Cell cycle analysis showed that the combination treatment increased G0/G1 phase and S phase arrest, and significantly increased the number of apoptotic cells. According to our previous study, ω -3 PUFAs induce apoptosis of gastric cells via ADORA1, a subtype of adenosine receptor functionally related to cell death. The ADORA1 mRNA and protein expression was higher in the combination treatment than in the individual treatments. Notable, when GC cells were pretreated with DPCPX, a selective ADORA1 antagonist, the combination treatment effect on apoptosis was significantly reduced. Our results suggest that ω-3 PUFAs enhance the antineoplastic effects of CDDP in gastric cancer cells, and the synergistic effect between ω-3 PUFAs and CDDP is partly dependent on activating the ADORA1-mediated apoptosis pathway.

  3. Absolute Proper Motions and Chemical Abundances of Stars Along the Sagittarius Trailing Tidal Tail

    Science.gov (United States)

    Carlin, Jeffrey L.; Majewski, S. R.; Casetti-Dinescu, D. I.; Patterson, R. J.

    2010-01-01

    We show results from our deep proper-motion survey of Kapteyn's Selected Areas (SAs; Casetti-Dinescu et al. 2006, AJ,132,2082), with a focus on fields that intersect the Sagittarius (Sgr) trailing tidal stream. Our data set, derived from matched, deep photographic plate pairs taken nearly 100 years apart, provides a unique window on the motions of stars in these SA fields. We find the signature of a common-motion population among our accurate proper motions of stars in five of these fields, as well as corresponding stellar excesses which are identified as stellar debris from the disrupted Sgr dwarf. Spectroscopic follow-up confirms that these stars are Sgr members, and the resultant radial velocities and spectroscopic parallaxes are combined with proper motions to derive full space motions of 30-100 tidal stream members per field. These kinematical data are compared to the predictions of the Law et al. (2009, ApJL,703,67) models of Sgr disruption, which have thus far reproduced most observed features of the Sgr stream, and have also constrained the triaxial shape of the Milky Way's dark matter halo. We also derive low-resolution spectroscopic abundances along this stretch of the Sgr stream, and explore the stream metallicity gradient reported by Chou et al. (2007, ApJ,670,346). Majewski et al. (2006, ApJL,627,25) showed that because the Sgr debris plane is nearly coincident with the Galactic X-Z Cartesian plane, proper motions in the portion of the Sgr trailing tail in our study almost entirely reflect the solar motion, and can be used to make a direct measurement of the rotation speed at the Solar circle (the "Local Standard of Rest") almost completely independent of the Sun's distance from the Galactic center. Here, we report our derived constraints on the solar motion from absolute proper motions of Sgr debris in our SA fields.

  4. Simultaneous, noninvasive, and transdermal extraction of urea and homocysteine by reverse iontophoresis

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    et al

    2011-02-01

    Full Text Available Congo Tak-Shing Ching1,2,3, Tzong-Ru Chou1, Tai-Ping Sun1,2, Shiow-Yuan Huang3, Hsiu-Li Shieh21Graduate Institute of Biomedicine and Biomedical Technology; 2Department of Electrical Engineering, National Chi Nan University, Nantou, Taiwan; 3Department of Photonics and Communication Engineering, Asia University, Taichung, Taiwan, Republic of ChinaBackground: Cardiovascular and kidney diseases are a global public health problem and impose a huge economic burden on health care services. Homocysteine, an amino acid, is associated with coronary heart disease, while urea is a harmful metabolic substance which can be used to reflect kidney function. Monitoring of these two substances is therefore very important. This in vitro study aimed to determine whether homocysteine is extractable transdermally and noninvasively, and whether homocysteine and urea can be extracted simultaneously by reverse iontophoresis.Methods: A diffusion cell incorporated with porcine skin was used for all experiments with the application of a direct current (dc and four different symmetrical biphasic direct currents (SBdc for 12 minutes via Ag/AgCl electrodes. The dc and the SBdc had a current density of 0.3 mA/cm2.Results: The SBdc has four different phase durations of 15 sec, 30 sec, 60 sec, and 180 sec. It was found that homocysteine can be transdermally extracted by reverse iontophoresis. Simultaneous extraction of homocysteine and urea by reverse iontophoresis is also possible.Conclusion: These results suggest that extraction of homocysteine and urea by SBdc are phase duration-dependent, and the optimum mode for simultaneous homocysteine and urea extraction is the SBdc with the phase duration of 60 sec.Keywords: reverse iontophoresis, homocysteine, urea, monitoring, noninvasive, transdermal

  5. Enhancement of tendon–bone healing via the combination of biodegradable collagen-loaded nanofibrous membranes and a three-dimensional printed bone-anchoring bolt

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    Chou YC

    2016-08-01

    Full Text Available Ying-Chao Chou,1,2 Wen-Lin Yeh,2 Chien-Lin Chao,1 Yung-Heng Hsu,1,2 Yi-Hsun Yu,1,2 Jan-Kan Chen,3 Shih-Jung Liu1,2 1Department of Mechanical Engineering, Chang Gung University, 2Department of Orthopedic Surgery, Chang Gung Memorial Hospital, 3Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan Abstract: A composite biodegradable polymeric model was developed to enhance tendon graft healing. This model included a biodegradable polylactide (PLA bolt as the bone anchor and a poly(D,L-lactide-co-glycolide (PLGA nanofibrous membrane embedded with collagen as a biomimic patch to promote tendon–bone interface integration. Degradation rate and compressive strength of the PLA bolt were measured after immersion in a buffer solution for 3 months. In vitro biochemical characteristics and the nanofibrous matrix were assessed using a water contact angle analyzer, pH meter, and tetrazolium reduction assay. In vivo efficacies of PLGA/collagen nanofibers and PLA bolts for tendon–bone healing were investigated on a rabbit bone tunnel model with histological and tendon pullout tests. The PLGA/collagen-blended nanofibrous membrane was a hydrophilic, stable, and biocompatible scaffold. The PLA bolt was durable for tendon–bone anchoring. Histology showed adequate biocompatibility of the PLA bolt on a medial cortex with progressive bone ingrowth and without tissue overreaction. PLGA nanofibers within the bone tunnel also decreased the tunnel enlargement phenomenon and enhanced tendon–bone integration. Composite polymers of the PLA bolt and PLGA/collagen nanofibrous membrane can effectively promote outcomes of tendon reconstruction in a rabbit model. The composite biodegradable polymeric system may be useful in humans for tendon reconstruction. Keywords: polylactide–polyglycolide nanofibers, PLGA, collagen, 3D printing, polylactide, PLA, bone-anchoring bolts, tendon healing

  6. Effective management of intractable neuropathic pain using an intrathecal morphine pump in a patient with acute transverse myelitis

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    Wu WT

    2013-07-01

    Full Text Available Wei-Ting Wu,1 Yu-Hui Huang,2,3 Der-Cherng Chen,4 Yu-Hsuan Huang,1 Li-Wei Chou1,5 1Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 3Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan; 4Center of Neuropsychiatry, Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan, 5School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, TaiwanAbstract: Transverse myelitis is a rare inflammatory myelopathy characterized by loss of motor and sensory function below the affected level of the spinal cord, and causes neurogenic bowel and bladder. Occasionally, it also causes neuropathic pain with spasticity. Traditional therapies for neuropathic pain are multiple, including multimodal analgesic regimens, antiepileptic or antidepressant medications, opioids, sympathetic blocks, and spinal cord stimulation. Persistent neuropathic pain can cause emotional distress by affecting sleep, work, recreation, and emotional well-being. Here we report the case of a patient suffering from intractable neuropathic pain following acute transverse myelitis that was not relieved by combinations of nonsteroidal anti-inflammatory, antiepileptic, antidepressant, and opioid medications, or by acupuncture. Implantation of an intrathecal morphine pump controlled the pain successfully without side effects, and enabled the patient to embark on intensive rehabilitation. The patient's muscle strength has improved significantly and the patient may soon be able to use a walker with minimal assistance.Keywords: intrathecal morphine pump, neuropathic pain, rehabilitation, transverse myelitis

  7. Designing inhibitors of M2 proton channel against H1N1 swine influenza virus.

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    Qi-Shi Du

    Full Text Available BACKGROUND: M2 proton channel of H1N1 influenza A virus is the target protein of anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The NMR structure of the M2 channel protein determined by Schnell and Chou (Nature, 2008, 451, 591-595 may help people to solve the drug-resistant problem and develop more powerful new drugs against H1N1 influenza virus. METHODOLOGY: Docking calculation is performed to build the complex structure between receptor M2 proton channel and ligands, including existing drugs amantadine and rimantadine, and two newly designed inhibitors. The computer-aided drug design methods are used to calculate the binding free energies, with the computational biology techniques to analyze the interactions between M2 proton channel and adamantine-based inhibitors. CONCLUSIONS: 1 The NMR structure of M2 proton channel provides a reliable structural basis for rational drug design against influenza virus. 2 The channel gating mechanism and the inhibiting mechanism of M2 proton channel, revealed by the NMR structure of M2 proton channel, provides the new ideas for channel inhibitor design. 3 The newly designed adamantane-based inhibitors based on the modeled structure of H1N1-M2 proton channel have two pharmacophore groups, which act like a "barrel hoop", holding two adjacent helices of the H1N1-M2 tetramer through the two pharmacophore groups outside the channel. 4 The inhibitors with such binding mechanism may overcome the drug resistance problem of influenza A virus to the adamantane-based drugs.

  8. Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1.

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    Jing-Fang Wang

    Full Text Available Human mitochondrial ornithine transporter-1 is reported in coupling with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH syndrome, which is a rare autosomal recessive disorder. For in-depth understanding of the molecular mechanism of the disease, it is crucially important to acquire the 3D structure of human mitochondrial ornithine transporter-1. Since no such structure is available in the current protein structure database, we have developed it via computational approaches based on the recent NMR structure of human mitochondrial uncoupling protein (Berardi MJ, Chou JJ, et al. Nature 2011, 476:109-113. Subsequently, we docked the ligand L-ornithine into the computational structure to search for the favorable binding mode. It was observed that the binding interaction for the most favorable binding mode is featured by six remarkable hydrogen bonds between the receptor and ligand, and that the most favorable binding mode shared the same ligand-binding site with most of the homologous mitochondrial carriers from different organisms, implying that the ligand-binding sites are quite conservative in the mitochondrial carriers family although their sequences similarity is very low with 20% or so. Moreover, according to our structural analysis, the relationship between the disease-causing mutations of human mitochondrial ornithine transporter-1 and the HHH syndrome can be classified into the following three categories: (i the mutation occurs in the pseudo-repeat regions so as to change the region of the protein closer to the mitochondrial matrix; (ii the mutation is directly affecting the substrate binding pocket so as to reduce the substrate binding affinity; (iii the mutation is located in the structural region closer to the intermembrane space that can significantly break the salt bridge networks of the protein. These findings may provide useful insights for in-depth understanding of the molecular mechanism of the HHH syndrome and

  9. Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1.

    Science.gov (United States)

    Wang, Jing-Fang; Chou, Kuo-Chen

    2012-01-01

    Human mitochondrial ornithine transporter-1 is reported in coupling with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, which is a rare autosomal recessive disorder. For in-depth understanding of the molecular mechanism of the disease, it is crucially important to acquire the 3D structure of human mitochondrial ornithine transporter-1. Since no such structure is available in the current protein structure database, we have developed it via computational approaches based on the recent NMR structure of human mitochondrial uncoupling protein (Berardi MJ, Chou JJ, et al. Nature 2011, 476:109-113). Subsequently, we docked the ligand L-ornithine into the computational structure to search for the favorable binding mode. It was observed that the binding interaction for the most favorable binding mode is featured by six remarkable hydrogen bonds between the receptor and ligand, and that the most favorable binding mode shared the same ligand-binding site with most of the homologous mitochondrial carriers from different organisms, implying that the ligand-binding sites are quite conservative in the mitochondrial carriers family although their sequences similarity is very low with 20% or so. Moreover, according to our structural analysis, the relationship between the disease-causing mutations of human mitochondrial ornithine transporter-1 and the HHH syndrome can be classified into the following three categories: (i) the mutation occurs in the pseudo-repeat regions so as to change the region of the protein closer to the mitochondrial matrix; (ii) the mutation is directly affecting the substrate binding pocket so as to reduce the substrate binding affinity; (iii) the mutation is located in the structural region closer to the intermembrane space that can significantly break the salt bridge networks of the protein. These findings may provide useful insights for in-depth understanding of the molecular mechanism of the HHH syndrome and developing effective

  10. Construct validity of the Depression and Somatic Symptoms Scale: evaluation by Mokken scale analysis

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    Chou YH

    2017-01-01

    Full Text Available Ya-Hsin Chou,1 Chin-Pang Lee,1,2 Chia-Yih Liu,1,2 Ching-I Hung1,2 1Department of Psychiatry, Chang-Gung Memorial Hospital at Linkou, 2School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan Objective: Previous studies of the Depression and Somatic Symptoms Scale (DSSS, a free scale, have been based on the classical test theory, and the construct validity and dimensionality of the DSSS are as yet uncertain. The aim of this study was to use Mokken scale analysis (MSA to assess the dimensionality of the DSSS.Methods: A sample of 214 psychiatric outpatients with mood and anxiety disorders were enrolled at a medical center in Taiwan (age: mean [SD] =38.3 [10.5] years; 63.1% female and asked to complete the DSSS. MSA was used to assess the dimensionality of the DSSS.Results: All 22 items of the DSSS formed a moderate unidimensional scale (Hs=0.403, supporting its construct validity. The DSSS was divided into 4 subscales (Hs ranged from 0.35 to 0.67, including a general somatic scale (GSS, melancholic scale (MS, muscular pain scale (MPS, and chest symptom scale (CSS. The GSS is a weak reliable Mokken scale; the other 3 scales are strong reliable Mokken scales.Conclusion: The DSSS is a psychometrically sound measure of depression and somatic symptoms in adult psychiatric outpatients with depression or anxiety. The summed score of the DSSS and its 4 subscales are valid statistics. Further research is required for replication of the 4 subscales of the DSSS. Keywords: depression, somatization, Mokken scale analysis, item response theory, construct validity

  11. Message sidedness in advertising: the moderating roles of need for cognition and time pressure in persuasion.

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    Kao, Danny Tengti

    2011-08-01

    Persuasion has been extensively researched for decades. Much of this research has focused on different message tactics and their effects on persuasion (e.g., Chang & Chou, 2008; Lafferty, 1999). This research aims to assess whether the persuasion of a specific type of message is influenced by need for cognition (NFC) and time pressure. The 336 undergraduates participated in a 2 (message sidedness: one-sided/two-sided) × 3 (time pressure: low/moderate/high) between-subjects design. Results indicate that two-sided messages tend to elicit more favorable ad attitudes than one-sided messages. As compared with low-NFC individuals, high-NFC individuals are likely to express more favorable ad attitudes, brand attitudes and purchase intention. Moderate time pressure tends to lead to more favorable ad attitudes than low time pressure and high time pressure. In addition, moderate time pressure is likely to elicit more favorable brand attitudes and purchase intentions than high time pressure, but does not elicit more favorable brand attitudes and purchase intentions than low time pressure. Furthermore, when high-NFC individuals are under low or moderate time pressure, two-sided messages are more persuasive than one-sided messages; however, message sidedness does not differentially affect the persuasion when high-NFC individuals are pressed for time. In contrast, one-sided messages are more persuasive than two-sided messages when low-NFC individuals are under low or high time pressure, and two-sided messages are more persuasive than one-sided messages when low-NFC individuals are under moderate time pressure.

  12. Polysaccharide from Sepia esculenta ink and cisplatin inhibit synergistically proliferation and metastasis of triple-negative breast cancer MDA-MB-231 cells.

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    Liu, Hua-Zhong; Xiao, Wei; Gu, Yi-Peng; Tao, Ye-Xing; Zhang, Da-Yan; Du, Hui; Shang, Jiang-Hua

    2016-12-01

    This paper aims to investigate synergistic inhibition of polysaccharide from Sepia esculenta ink (SIP), a newly isolated marine polysaccharide in our laboratory, on breast cancer MDA-MB-231 cells exposed to cisplatin. Cell viability of MDA-MB-231 cells was determined by CCK 8 assay. Median-effect concentration was analyzed using Chou-Talalay method that was also subjected to determine cell inhibition ratio and combined index, as well as interaction between SIP and cisplatin. Proliferation and migration abilities were detected with plate colony formation assay and cell wound scratch assay, respectively. Expression of MMP-2 and MMP-9 proteins was measured with Western blot assay. Data showed that SIP not only suppressed proliferation and migration of MDA-MB-231 cells, and expression of MMP-2 and MMP-9 proteins, also promoted inhibition of cisplatin on proliferation, migration and MMPs expression of MDA-MB-231 cells, which indicates synergy inhibition of drug combination of SIP and cisplatin on breast cancer cells. The median-effect concentrations of cisplatin and SIP were 4.9 and 1659.6 μg/ml, respectively. Whereas the concentration of combination drug was 158.5 μg/ml. The data indicated that drug combination can decrease dosages of the two single agents, especially the usual dosage of cisplatin. This research demonstrated that SIP repressed proliferation and metastasis of MDA-MB-231 cells and promoted anticancer effect of cisplatin on the breast cancer cells. The data suggested that SIP is a potential natural drug that can be used as an auxiliary medicine alongside chemotherapy in treating breast cancer.

  13. Enzymes/non-enzymes classification model complexity based on composition, sequence, 3D and topological indices.

    Science.gov (United States)

    Munteanu, Cristian Robert; González-Díaz, Humberto; Magalhães, Alexandre L

    2008-09-21

    The huge amount of new proteins that need a fast enzymatic activity characterization creates demands of protein QSAR theoretical models. The protein parameters that can be used for an enzyme/non-enzyme classification includes the simpler indices such as composition, sequence and connectivity, also called topological indices (TIs) and the computationally expensive 3D descriptors. A comparison of the 3D versus lower dimension indices has not been reported with respect to the power of discrimination of proteins according to enzyme action. A set of 966 proteins (enzymes and non-enzymes) whose structural characteristics are provided by PDB/DSSP files was analyzed with Python/Biopython scripts, STATISTICA and Weka. The list of indices includes, but it is not restricted to pure composition indices (residue fractions), DSSP secondary structure protein composition and 3D indices (surface and access). We also used mixed indices such as composition-sequence indices (Chou's pseudo-amino acid compositions or coupling numbers), 3D-composition (surface fractions) and DSSP secondary structure amino acid composition/propensities (obtained with our Prot-2S Web tool). In addition, we extend and test for the first time several classic TIs for the Randic's protein sequence Star graphs using our Sequence to Star Graph (S2SG) Python application. All the indices were processed with general discriminant analysis models (GDA), neural networks (NN) and machine learning (ML) methods and the results are presented versus complexity, average of Shannon's information entropy (Sh) and data/method type. This study compares for the first time all these classes of indices to assess the ratios between model accuracy and indices/model complexity in enzyme/non-enzyme discrimination. The use of different methods and complexity of data shows that one cannot establish a direct relation between the complexity and the accuracy of the model.

  14. Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity

    Science.gov (United States)

    Bedoya, Luis M.; Beltrán, Manuela; Obregón-Calderón, Patricia; García-Pérez, Javier; de la Torre, Humberto E.; González, Nuria; Pérez-Olmeda, Mayte; Auñón, David; Capa, Laura; Gómez-Acebo, Eduardo; Alcamí, José

    2016-01-01

    Objective: To investigate the toxicity and activity against HIV of 5-hydroxytyrosol as a potential microbicide. Design: The anti-HIV-1 activity of 5-hydroxytyrosol, a polyphenolic compound, was tested against wild-type HIV-1 and viral clones resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors and integrase inhibitors. In addition to its activity against founder viruses, different viral subtypes and potential synergy with tenofovir disoproxil fumarate, lamivudine and emtricitabine was also tested. 5-Hydroxytyrosol toxicity was evaluated in vivo in rabbit vaginal mucosa. Methods: We have cloned pol gene from drug-resistant HIV-1 isolated from infected patients and env gene from Fiebeg III/IV patients or A, C, D, E, F and G subtypes in the NL4.3-Ren backbone. 5-Hydroxytyrosol anti-HIV-1 activity was evaluated in infections of MT-2, U87-CCR5 or peripheral blood mononuclear cells preactivated with phytohemagglutinin + interleukin-2 with viruses obtained through 293T transfections. Inhibitory concentration 50% and cytotoxic concentration 50% were calculated. Synergy was analysed according to Chou and Talalay method. In-vivo toxicity was evaluated for 14 days in rabbit vaginal mucosa. Results: 5-Hydroxytyrosol inhibited HIV-1 infections of recombinant or wild-type viruses in all the target cells tested. Moreover, 5-hydroxytyrosol showed similar inhibitory concentration 50% values for infections with NRTIs, NNRTIs, protease inhibitors and INIs resistant viruses; founder viruses and all the subtypes tested. Combination of 5-hydroxytyrosol with tenofovir was found to be synergistic, whereas it was additive with lamivudine and emtricitabine. In-vivo toxicity of 5-hydroxytyrosol was very low even at the highest tested doses. Conclusion: 5-Hydroxytyrosol displayed a broad anti-HIV-1 activity in different cells systems in the absent of in-vivo toxicity, therefore supporting its

  15. Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells.

    Science.gov (United States)

    Soares, Daniele G; Machado, Miriana S; Rocca, Céline J; Poindessous, Virginie; Ouaret, Djamila; Sarasin, Alain; Galmarini, Carlos M; Henriques, João A P; Escargueil, Alexandre E; Larsen, Annette K

    2011-08-01

    PM01183 is a novel marine-derived covalent DNA binder in clinical development. PM01183 is structurally similar to trabectedin (yondelis, ecteinascidin-743) except for the C subunit, and this modification is accompanied by different pharmacokinetics in cancer patients. We here characterize the interaction of PM01183 with the nucleotide excision repair (NER) pathway in comparison with trabectedin. Our results show for the first time that although neither PM01183 nor trabectedin is repaired by NER, both compounds are able to interfere with the NER machinery thereby attenuating the repair of specific NER substrates. We further show that the NER activity is increased in 3 of 4 cellular models with acquired resistance to cisplatin or oxaliplatin, confirming the involvement of NER in the resistance to platinum derivatives. Importantly, both PM01183 and trabectedin show unchanged or even enhanced activity toward all 4 cisplatin- and oxaliplatin-resistant cell lines. We finally show that combinations of PM01183 and cisplatin were mostly synergistic toward both parental and cisplatin-resistant ovarian carcinoma cells as indicated by Chou and Talalay analysis. These data show that the C subunit of trabectedin can be subjected to at least some structural modifications without loss of activity or NER interaction. While PM01183 and trabectedin appear functionally similar in cellular models, it is likely that the differences in pharmacokinetics may allow different dosing and scheduling of PM01183 in the clinic that could lead to novel and/or increased antitumor activity. Taken together, our results provide a mechanistic basis to support clinical trials of PM01183 alone or in combination with cisplatin.

  16. TWO NEW SPECIES OF THE ORIENTAL PLANTHOPPER GENUS HEMISPHAERIUS SCHAUM (HEMIPTERA, ISSIDAE)%中国球瓢蜡蝉属二新种记述(半翅目,瓢蜡蝉科)

    Institute of Scientific and Technical Information of China (English)

    车艳丽; 张雅林; 王应伦

    2006-01-01

    1丽球瓢蜡蝉Hemisphaerius lysanias Fennah Gergithus esperauto Chou et Lu,1985:122,新异名观察标本:1♂(Gergitnus esperauto Chou et Lu的正模,原文记述为1♀,实际标本为雄虫),海南海口,1964-05-29,刘思孔采;1♂,海南岛保亭,1964-04-12,刘思孔采;1♂,海南马岭,1974-12-18,杨集昆采;2♂♂,海南尖峰岭,1981-01-6/8,陈振耀采;1♂,1♀,海南吊罗山,1983-05-23,张雅林采;1♂,海南岛尖峰岭,1983-05-26,张雅林采;3♂♂,2♀♀,海南琼中牙畜岭,2002-07-02,王培明采;21♂♂,7♀♀,海南定安县翰林,2002-07-26,王宗庆、车艳丽采;1♂,3♀♀,海南吊罗山,2002-08-16,王培明采;1♀,海南定安县岭口,2002-08-25,王宗庆、车艳丽采.2三瓣球瓢蜡蝉,新种Hemisphaerius trilobulus sp.nov.本种与H.tappanus Matsumura相似,但可从以下特征区分:1)前者前翅中域及边缘分别具有1斜条纹,条纹之间具有1个圆斑,后者翅近端部具2斜条纹;2)前者唇基端部具横带,后者唇基中央具2条纵带.正模♂,云南勐腊,1991-05-15,王应伦、彩万志采.副模:2♀♀,云南西双版纳勐仑,1974-04-21/30,周尧、袁锋、胡隐月采;2♂♂,3♀♀,云南西双版纳勐仑,1982-04-17/24,周静若、王素梅采;20♂♂,云南勐腊瑶区,1991-04-08/22,王应伦、彩万志采;10♀♀,云南勐腊瑶区,1991-05-07/11,王应伦、彩万志采.3双斑球瓢蜡蝉,新种Hemisphaerius bimaculatus sp.nov.本种与H.palaemon Fennah相近似,但可从以下特征区分:1)后翅仅为前翅的0.4倍,后者后翅为前翅的0.5;2)后足刺式6-10-2,后者6-9-2;3)额的端部具有2个浅色的斑,后者无.正模♂,福建天游,1982-06-27,张万池采.副模2♀♀,福建武夷宫,1982-06-26,齐石成采;1♀,福建戴云山,1984-07-30,崔志新采.%In the present paper, two new species, Hemisphaerius bimaculatus sp. nov. and Hemisphaerius trilobulus sp. nov.are described and illustrated, H. lysanius Fennah from Viemam is illustrated and found to be a senior

  17. A family-oriented treatment program for youths with ketamine abuse and their caregivers: a pilot study in Taiwan

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    Wang LJ

    2015-07-01

    Full Text Available Liang-Jen Wang,1 Shing-Fang Lu,1 Wen-Jiun Chou,1 Mian-Yoon Chong,2 Yao-Hsing Wang,1 Yu-Lian Hsieh,1 Yi-Hsuan Lee,1 Ching Chen2 1Department of Child and Adolescent Psychiatry, 2Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Objective: The abuse of ketamine by youths has grown into a serious public health issue. However, a reliable and efficient treatment has still not been found for youths who abuse ketamine. This pilot study investigated the effects of a family-oriented treatment program for ketamine-using youths and their caregivers.Methods: To carry out this study, 42 youths with ketamine use (mean age 16.6±1.1 years who were referred to take part in a 10-week treatment program based on motivational enhancement principles were selected, as were their principal caregivers (mean age 46.4±7.1 years, who were similarly referred to take part in a 10-week training program for parenting skills. The study had the youths complete the Chinese Craving Beliefs Questionnaire, the Adolescents’ Behavior problem Scale, and the Family APGAR both immediately before and after the program. Likewise, the youths’ caregivers completed the Family APGAR, the 12-item version of the Chinese Health Questionnaire, and the Parenting Stress Index.Results: Of the 42 youth–caregiver pairs that took part in this study, 37 (88% completed the 10-week program and both sets of assessments. After the treatment, the participating youths’ substance cravings declined (t=3.88, P<0.001, while family function, as perceived by the participating caregivers, significantly increased (t=2.22, P=0.033. The improvement in caregivers’ perceptions of family function were positively related to the improvement of the caregivers’ health status (r=-0.36, P=0.022.Conclusion: According to its results, this pilot study submits that family-oriented treatment programs may be considered a potentially effective

  18. Risk of breast cancer recurrence in patients receiving manual lymphatic drainage: a hospital-based cohort study

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    Hsiao PC

    2015-02-01

    Full Text Available Pei-Chi Hsiao,1,2 Jung-Tai Liu,3 Chien-Liang Lin,4 Willy Chou,1,2 Shiang-Ru Lu5 1Department of Physical Medicine and Rehabilitation, Chi-Mei Medical Center, Tainan, Taiwan; 2Department of Recreation and Health Care Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; 3Departments of Physical Medicine and Rehabilitation, Chi-Mei Medical Center Liouying Campus, Tainan, Taiwan; 4Department of Hematology and Oncology, Chi-Mei Medical Center Liouying Campus, Tainan, Taiwan; 5Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Background: This retrospective cohort study evaluated whether manual lymphatic drainage (MLD therapy increases the risk of recurrence of breast cancer. Methods: We analyzed 1,106 women who were diagnosed with stage 0­–3 breast cancer between 2007 and 2011 and experienced remission after surgery and adjuvant therapy. The patients were divided into two groups: group A (n=996, in which patients did not participate in any MLD therapy, regardless of whether they developed breast cancer-related lymphedema (BCRL after cancer treatment; and group B (n=110, in which patients participated in MLD therapy for BCRL. All patients were monitored until October 2013 to determine whether breast cancer recurrence developed, including local or regional recurrence and distant metastasis. Patients who developed cancer recurrence prior to MLD therapy were excluded from analysis. Risk factors associated with cancer recurrence were evaluated using Cox proportional hazards models. Results: During the monitoring period, 166 patients (15.0% developed cancer recurrence, including 154 (15.5% in group A and 12 (10.9% in group B. The median period from surgery to cancer recurrence was 1.85 (interquartile range 1.18–2.93 years. Independent risk factors for cancer recurrence were tumor histological grading of grade 3, high number (≥3 of axillary lymph node invasion, and a large tumor size (>5 cm. Factors

  19. GalNAc-transferase specificity prediction based on feature selection method.

    Science.gov (United States)

    Lu, Lin; Niu, Bing; Zhao, Jun; Liu, Liang; Lu, Wen-Cong; Liu, Xiao-Jun; Li, Yi-Xue; Cai, Yu-Dong

    2009-02-01

    GalNAc-transferase can catalyze the biosynthesis of O-linked oligosaccharides. The specificity of GalNAc-transferase is composed of nine amino acid residues denoted by R4, R3, R2, R1, R0, R1', R2', R3', R4'. To predict whether the reducing monosaccharide will be covalently linked to the central residue R0(Ser or Thr), a new method based on feature selection has been proposed in our work. 277 nonapeptides from reference [Chou KC. A sequence-coupled vector-projection model for predicting the specificity of GalNAc-transferase. Protein Sci 1995;4:1365-83] are chosen for training set. Each nonapeptide is represented by hundreds of amino acid properties collected by Amino Acid Index database (http://www.genome.jp/aaindex) and transformed into a numeric vector with 4554 features. The Maximum Relevance Minimum Redundancy (mRMR) method combining with Incremental Feature Selection (IFS) and Feature Forward Selection (FFS) are then applied for feature selection. Nearest Neighbor Algorithm (NNA) is used to build prediction models. The optimal model contains 54 features and its correct rate tested by Jackknife cross-validation test reaches 91.34%. Final feature analysis indicates that amino acid residues at position R3' play the most important role in the recognition of GalNAc-transferase specificity, which were confirmed by the experiments [Elhammer AP, Poorman RA, Brown E, Maggiora LL, Hoogerheide JG, Kezdy FJ. The specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase as inferred from a database of in vivo substrates and from the in vitro glycosylation of proteins and peptides. J Biol Chem 1993;268:10029-38; O'Connell BC, Hagen FK, Tabak LA. The influence of flanking sequence on the O-glycosylation of threonine in vitro. J Biol Chem 1992;267:25010-8; Yoshida A, Suzuki M, Ikenaga H, Takeuchi M. Discovery of the shortest sequence motif for high level mucin-type O-glycosylation. J Biol Chem 1997;272:16884-8]. Our method can be used as a tool for predicting O

  20. Adjunct effect of music therapy on cognition in Alzheimer’s disease in Taiwan: a pilot study

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    Li CH

    2015-02-01

    Full Text Available Chien-Hsun Li,1–3 Ching-Kuan Liu,2,3 Yuan-Han Yang,2–4 Mei-Chuan Chou,2,4 Chun-Hung Chen,2 Chiou-Lian Lai2,3 1Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 3Department of and Master’s Program in Neurology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 4Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan Purpose: Music therapy (MT reviews have found beneficial effects on behaviors and social interaction in Alzheimer’s disease (AD but inconsistent effects on cognition. The purpose of the study was to evaluate the adjunct effect of long-term and home-based MT in AD patients under pharmacological treatment. Patients and methods: Mild AD cases (clinical dementia rating =0.5~1 were consecutively recruited and voluntarily separated into an MT group or control group (CG for 6 months. Outcome assessments included Cognitive Abilities Screening Instrument (CASI, CASI-estimated mini-mental state examination, clinical dementia rating with sum of box scores, and neuropsychiatric inventory. The MT interventions were Mozart’s Sonata (KV 448 and Pachelbel’s Canon, listening with headphones for 30 minutes daily in the morning and before sleep, respectively. Results: Forty-one cases (MT versus CG number =20 versus 21 were analyzed. Adjusted differences of CASI-estimated mini-mental state examination and CASI after 6 months in the MT group were slightly less decreased than the CG without statistical significance. In further analysis of cognitive domains of CASI, the adjusted difference of abstraction domain in the MT group was significantly better than the CG. Conclusion: Although there were no apparent additional benefits of this MT on the global cognition and daily functioning in mild AD patients, it confirms the adjunct

  1. 试论明代折子戏在净脚演化中的作用

    Institute of Scientific and Technical Information of China (English)

    尤海燕

    2012-01-01

    In the Ming Dynasty legendary, the role of " Jing" contains rich meaning. The emergence of Zhezi Opera accelerates the differentiation of the role of "Jing" from other roles, especially the role of "Chou" (clown), in function as well as in content, and the role of "Jing" has gradually gained the attributes of straightforwardness and unconstrained boldness. Zhezi opera has rendered the transformation of the role of "Jing" from a supporting role in the full play to a leading actor in the specific excerpt, giving full play to the characteristics of the role and intensifying the characteristics in the repetition of performance. The development of Zhezi opera has promoted the subdivision of all roles, offering opportunities to exhibit their talent as the leading performers to the full extent role thus forming the distinctive characteristics of each type of role, and the evolvement of the role of "Jing" is an excellent example as such.%在明代传奇中,净的脚色内涵是非常丰富的。折子戏的出现,加速了净脚与其他脚色尤其是丑脚在职责、内涵上的分化,净脚逐渐形成以粗犷豪放为底色的行当特征。折子戏使净脚从全本中的配角成为本出的主角,最大程度地发挥本行当的特点,并在反复演出中强化这些特点。折子戏的发展促进了各种脚色的细分,让每种脚色都有作为主角尽情发挥的机会,从而形成了各自行当的鲜明特色,净脚的发展就是一个很好的例证。

  2. Family caregivers’ role implementation at different stages of dementia

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    Huang HL

    2015-01-01

    Full Text Available Huei-Ling Huang,1 Yea-Ing L Shyu,2,3 Min-Chi Chen,4 Chin-Chang Huang,5,6 Hung-Chou Kuo,5,6 Sien-Tsong Chen,5,6 Wen-Chuin Hsu6,71Department of Gerontological Care and Management, Chang Gung University of Science and Technology, Taoyuan, Taiwan; 2School of Nursing, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; 4Department of Public Health and Biostatistics Consulting Center, Chang Gung University, Taoyuan, Taiwan; 5Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 6School of Medicine, Chang Gung University, Taoyuan, Taiwan; 7Chang Gung Dementia Center, Taoyuan, TaiwanPurpose: The purpose of this study was to explore family caregivers’ role-implementation experiences at different stages of dementia.Patients and methods: For this cross-sectional, exploratory study, 176 dyads of family caregivers and their community-dwelling elderly relatives with dementia were recruited from the neurological clinics of a medical center in Taiwan. The Family Caregiving Inventory was used to assess family caregivers for caregiving activities, role strain, role preparation, and help from others at different stages of care receivers’ dementia.Results: Family caregivers’ caregiving activities were related to patients’ stages of dementia. For patients with mild dementia, caregivers provided more assistance in transportation and housekeeping. In addition to these two activities, family caregivers of patients with moderate dementia provided more assistance with mobility and protection. For patients with severe dementia, family caregivers provided more assistance with personal care, mobility and protection, transportation, and housekeeping. Overall, family caregivers reported having some preparation to provide care; the most difficult caregiving activity was identified as managing behavioral problems.Conclusion: This study’s results provide a knowledge base

  3. Ultrasound sonication with microbubbles disrupts blood vessels and enhances tumor treatments of anticancer nanodrug

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    Lin CY

    2012-04-01

    Full Text Available Chung-Yin Lin1*, Hsiao-Ching Tseng1*, Heng-Ruei Shiu1, Ming-Fang Wu2, Cheng-Ying Chou3, Win-Li Lin1,41Institute of Biomedical Engineering, 2Laboratory Animal Center, 3Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei, Taiwan; 4Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan*These authors contributed equally to this workAbstract: Ultrasound (US sonication with microbubbles (MBs has the potential to disrupt blood vessels and enhance the delivery of drugs into the sonicated tissues. In this study, mouse ear tumors were employed to investigate the therapeutic effects of US, MBs, and pegylated liposomal doxorubicin (PLD on tumors. Tumors started to receive treatments when they grew up to about 15 mm3 (early stage with injection of PLD 10 mg/kg, or up to 50 mm3 (medium stage with PLD 6 (or 4 mg/kg. Experiments included the control, PLD alone, PLD + MBs + US, US alone, and MBs + US groups. The procedure for the PLD + MBs + US group was that PLD was injected first, MB (SonoVue injection followed, and then US was immediately sonicated on the tumor. The results showed that: (1 US sonication with MBs was always able to produce a further hindrance to tumor growth for both early and medium-stage tumors; (2 for the medium-stage tumors, 6 mg/kg PLD alone was able to inhibit their growth, while it did not work for 4 mg/kg PLD alone; (3 with the application of MBs + US, 4 mg/kg PLD was able to inhibit the growth of medium-stage tumors; (4 for early stage tumors after the first treatment with a high dose of PLD alone (10 mg/kg, the tumor size still increased for several days and then decreased (a biphasic pattern; (5 MBs + US alone was able to hinder the growth of early stage tumors, but unable to hinder that of medium stage tumors. The results of histological examinations and blood perfusion measurements indicated that the application of MBs + US disrupts the tumor blood

  4. Mathematical modeling of postcoinfection with influenza A virus and Streptococcus pneumoniae, with implications for pneumonia and COPD-risk assessment

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    Cheng YH

    2017-07-01

    Full Text Available Yi-Hsien Cheng,1 Shu-Han You,2 Yi-Jun Lin,3 Szu-Chieh Chen,4,5 Wei-Yu Chen,6 Wei-Chun Chou,2 Nan-Hung Hsieh,7 Chung-Min Liao3 1Institute of Computational Comparative Medicine (ICCM, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA; 2National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, 3Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, 4Department of Public Health, 5Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, 6Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan; 7Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA Background: The interaction between influenza and pneumococcus is important for understanding how coinfection may exacerbate pneumonia. Secondary pneumococcal pneumonia associated with influenza infection is more likely to increase respiratory morbidity and mortality. This study aimed to assess exacerbated inflammatory effects posed by secondary pneumococcal pneumonia, given prior influenza infection. Materials and methods: A well-derived mathematical within-host dynamic model of coinfection with influenza A virus and Streptococcus pneumoniae (SP integrated with dose–response relationships composed of previously published mouse experimental data and clinical studies was implemented to study potentially exacerbated inflammatory responses in pneumonia based on a probabilistic approach. Results: We found that TNFα is likely to be the most sensitive biomarker reflecting inflammatory response during coinfection among three explored cytokines. We showed that the worst inflammatory effects would occur at day 7 SP coinfection, with risk probability of 50% (likely to develop severe

  5. Dilemma of prescribing aripiprazole under the Taiwan health insurance program: a descriptive study

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    Hsu YC

    2015-01-01

    Full Text Available Yi-Chien Hsu,1,2 Yu-Ching Chou,3 Hsin-An Chang,1,2,4 Yu-Chen Kao,1,2,5 San-Yuan Huang,1,2 Nian-Sheng Tzeng1,2,4 1Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan; 2School of Medicine, 3School of Public Health, 4Student Counseling Center, National Defense Medical Center, Taipei, Taiwan; 5Department of Psychiatry, Tri-Service General Hospital, Song-Shan Branch, Taipei, Taiwan Objectives: Refractory major depressive disorder (MDD is a serious problem leading to a heavy economic burden. Antipsychotic augmentation treatment with aripiprazole and quetiapine is approved for MDD patients and can achieve a high remission rate. This study aimed to examine how psychiatrists in Taiwan choose medications and how that choice is influenced by health insurance payments and administrative policy.Design: Descriptive study.Outcome measures: Eight questions about the choice of treatment strategy and atypical antipsychotics, and the reason to choose aripiprazole.Intervention: We designed an augmentation strategy questionnaire for psychiatrists whose patients had a poor response to antidepressants, and handed it out during the annual meeting of the Taiwanese Society of Psychiatry in October 2012. It included eight questions addressing the choice of treatment strategy and atypical antipsychotics, and the reason whether or not to choose aripiprazole as the augmentation antipsychotic.Results: Choosing antipsychotic augmentation therapy or switching to other antidepressant strategies for MDD patients with an inadequate response to antidepressants was common with a similar probability (76.1% vs 76.4%. The most frequently used antipsychotics were aripiprazole and quetiapine, however a substantial number of psychiatrists chose olanzapine, risperidone, and sulpiride. The major reason for not choosing aripiprazole was cost (52.1%, followed by insurance official policy audit and deletion in the claims review system (30.1%.Conclusion: The prescribing

  6. The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells.

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    Lotte M E Berghauser Pont

    Full Text Available A phase I/II trial for glioblastoma with the oncolytic adenovirus Delta24-RGD was recently completed. Delta24-RGD conditionally replicates in cells with a disrupted retinoblastoma-pathway and enters cells via αvβ3/5 integrins. Glioblastomas are differentially sensitive to Delta24-RGD. HDAC inhibitors (HDACi affect integrins and share common cell death pathways with Delta24-RGD. We studied the combination treatment effects of HDACi and Delta24-RGD in patient-derived glioblastoma stem-like cells (GSC, and we determined the most effective HDACi.SAHA, Valproic Acid, Scriptaid, MS275 and LBH589 were combined with Delta24-RGD in fourteen distinct GSCs. Synergy was determined by Chou Talalay method. Viral infection and replication were assessed using luciferase and GFP encoding vectors and hexon-titration assays. Coxsackie adenovirus receptor and αvβ3 integrin levels were determined by flow cytometry. Oncolysis and mechanisms of cell death were studied by viability, caspase-3/7, LDH and LC3B/p62, phospho-p70S6K. Toxicity was studied on normal human astrocytes. MGMT promotor methylation status, TCGA classification, Rb-pathway and integrin gene expression levels were assessed as markers of responsiveness.Scriptaid and LBH589 acted synergistically with Delta24-RGD in approximately 50% of the GSCs. Both drugs moderately increased αvβ3 integrin levels and viral infection in responding but not in non-responding GSCs. LBH589 moderately increased late viral gene expression, however, virus titration revealed diminished viral progeny production by both HDACi, Scriptaid augmented caspase-3/7 activity, LC3B conversion, p62 and phospho-p70S6K consumption, as well as LDH levels. LBH589 increased LDH and phospho-p70S6K consumption. Responsiveness correlated with expression of various Rb-pathway genes and integrins. Combination treatments induced limited toxicity to human astrocytes.LBH589 and Scriptaid combined with Delta24-RGD revealed synergistic anti

  7. Timing of antiretroviral therapy and TB treatment outcomes in patients with TB-HIV in Myanmar.

    Science.gov (United States)

    Thi, A M; Shewade, H D; Kyaw, N T T; Oo, M M; Aung, T K; Aung, S T; Oo, H N; Win, T; Harries, A D

    2016-06-21

    Contexte : Programme intégré de prise en charge du virus de l'immunodéficience humaine (VIH), Mandalay, Myanmar.Objectifs : Chez les patients atteints de tuberculose (TB) et VIH enrôlés entre 2011 et 2014, déterminer la date du début du traitement antirétroviral (TAR) en relation avec le traitement antituberculeux (ATT) et son association avec le résultat d'ATT.Schéma : Etude rétrospective de cohorte.Résultats : Sur 1708 patients TB-VIH, 1565 (92%) ont débuté l'ATT en premier et 143 (8%) ont commencé le TAR en premier. Le résultat du traitement a été manquant pour 226 patients qui n'ont pas été inclus. Chez les patients ayant débuté l'ATT en premier, le délai médian de mise en route du TAR a été de 8,6 semaines. L'initiation du TAR a été retardée d'un délai médian de 8 semaines chez 830 (53%) patients. Parmi ces patients, 7% ont eu un résultat médiocre, avec une anémie qui a constitué un facteur de risque indépendant. Chez les patients ayant débuté le TAR en premier, le délai médian de mise en route de l'ATT a été de 21,6 semaines. L'ATT a été initié au cours des 3 mois chez 56 (39%) patients. Le traitement a échoué chez 12% des patients et chez 20% de ceux qui ont débuté l'ATT dans les 3 mois. Les patients ayant des CD4 VIH et un suivi étroit de l'anémie et de l'immunosuppression sont recommandés afin d'améliorer encore le résultat du traitement de TB parmi les patients TB-VIH.

  8. Rhodiola crenulata- and Cordyceps sinensis-Based Supplement Boosts Aerobic Exercise Performance after Short-Term High Altitude Training

    Science.gov (United States)

    Chen, Chung-Yu; Hou, Chien-Wen; Bernard, Jeffrey R.; Chen, Chiu-Chou; Hung, Ta-Cheng; Cheng, Lu-Ling; Liao, Yi-Hung

    2014-01-01

    Abstract Chen, Chung-Yu, Chien-Wen Hou, Jeffrey R. Bernard, Chiu-Chou Chen, Ta-Cheng Hung, Lu-Ling Cheng, Yi-Hung Liao, and Chia-Hua Kuo. Rhodiola crenulata- and Cordyceps sinensis-based supplement boosts aerobic exercise performance after short-term high altitude training. High Alt Med Biol 15:371–379, 2014.—High altitude training is a widely used strategy for improving aerobic exercise performance. Both Rhodiola crenulata (R) and Cordyceps sinensis (C) supplements have been reported to improve exercise performance. However, it is not clear whether the provision of R and C during high altitude training could further enhance aerobic endurance capacity. In this study, we examined the effect of R and C based supplementation on aerobic exercise capacity following 2-week high altitude training. Alterations to autonomic nervous system activity, circulatory hormonal, and hematological profiles were investigated. Eighteen male subjects were divided into two groups: Placebo (n=9) and R/C supplementation (RC, n=9). Both groups received either RC (R: 1400 mg+C: 600 mg per day) or the placebo during a 2-week training period at an altitude of 2200 m. After 2 weeks of altitude training, compared with Placebo group, the exhaustive run time was markedly longer (Placebo: +2.2% vs. RC: +5.7%; p<0.05) and the decline of parasympathetic (PNS) activity was significantly prevented in RC group (Placebo: −51% vs. RC: −41%; p<0.05). Red blood cell, hematocrit, and hemoglobin levels were elevated in both groups to a comparable extent after high altitude training (p<0.05), whereas the erythropoietin (EPO) level remained higher in the Placebo group (∼48% above RC values; p<0.05). The provision of an RC supplement during altitude training provides greater training benefits in improving aerobic performance. This beneficial effect of RC treatment may result from better maintenance of PNS activity and accelerated physiological adaptations during high altitude training. PMID

  9. Eclipses and the Olympics

    Science.gov (United States)

    Pang, K. D.; Yau, K. K.

    2000-12-01

    Like returns of Halley's comet the Olympic games occur periodically, though not as regularly in antiquity. Dates were also imprecise due to the chaotic calendars in use. Reported sightings of comets and eclipses can be used with game dates to help fix ancient events. However some reported darkening of the sun, e.g., after Julius Caesar's murder in 44 BC, was due to volcanic eruptions. A red comet, visible in daylight, first appeared during the games that year. It was also seen from China and Korea (Pang, Sciences 31, 30). Phlegon's ``Olympiads" (2nd century) says that Christ's crucifixion was in the 4th year of the 202nd Olympiad (AD 29-33), when a total solar eclipse occurred in the 6th hour. Only the Nov. 24, AD 29 eclipse over Asia Minor can match that, and Joel's prophecy (Acts 2, 14-21) that ``the sun will be turned to darkness and moon to blood." However it conflicts with ``the first day of Passover," as recorded by Mathew, Mark and Luke, i.e., full moon in early spring. Humphreys and Waddington (Nature 306, 743) have suggested meteorological darkening and the April 3, AD 33 lunar eclipse instead. Schaefer has questioned the eclipse's visibility from Jerusalem (31.46N, 35.14E). The six computations he cited gave dissimilar answers due to the imprecise rates of the secular lunar acceleration, and lengthening of the day used (Q.Jl.R.astr.Soc. 31, 53). Lunar laser ranging has since fixed the former at -26"/cen2. Analysis of ancient Chinese solar eclipse records, e.g., the April 21, 899 BC and April 4, AD 368 ``double dawns" over Zheng, has given us a delta T (in sec) = 30t2, where t is centuries before 1800 (Pang, Yau and Chou, in ``Dynamics of Ice Age Earth: A Modern Perspective," 1998). Our computations show that the moon rose over Jerusalem, with 1/3 still in the umbra and the rest in penumbra. Holdover meteorological darkening with long absorption air mass could have help reddened the moon also. Finally the first ``eclipse season" (the Aug. 21 lunar, and

  10. The clinical outcomes of oldest old patients with tuberculosis treated by regimens containing rifampicin, isoniazid, and pyrazinamide

    Directory of Open Access Journals (Sweden)

    Lin HS

    2016-03-01

    Full Text Available Huang-Shen Lin,1,2 Chun-Wen Cheng,3 Ming-Shyan Lin,4 Yen-Li Chou,5 Pey-Jium Chang,2 Jing-Chi Lin,6 Jung-Jr Ye3 1Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chia-Yi, 2Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, 3Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, 4Division of Cardiology, Chang Gung Memorial Hospital, Yunlin, 5Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Chia-Yi, 6Division of Allergy and Immunology and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chia-Yi, Taiwan Objectives: To investigate the clinical characteristics, adverse drug reactions, and outcomes of the oldest old patients (aged ≥80 years with tuberculosis (TB treated with rifampicin, isoniazid, and pyrazinamide (RIP-containing regimens. Design: A retrospective chart review study. Setting: A 1,200-bed tertiary teaching hospital in southwest Taiwan. Participants: We conducted a retrospective observational study between January 1, 2005 and December 31, 2011. Seven hundred adult patients (aged ≥18 years with TB treated with RIP-containing anti-TB regimens were reviewed, including 161 oldest old patients. Outcome measures: Clinical outcomes included clinical responsiveness and microbiological eradication. Adverse outcomes included drug-induced hepatitis, and other symptoms included gastrointestinal upset (eg, abdominal pain, vomiting, diarrhea, or dyspepsia, skin rash, joint pain, and hyperuricemia. Results: Compared with the non-oldest old adult patients, the oldest old patients more frequently had hepatitis (P=0.014, gastrointestinal upset (P=0.029, and unfavorable outcomes (P<0.001. In a multivariate analysis, hepatitis during treatment (adjusted odds ratio

  11. Management and treatment outcomes of patients enrolled in MDR-TB treatment in Viet Nam.

    Science.gov (United States)

    Phuong, N T M; Nhung, N V; Hoa, N B; Thuy, H T; Takarinda, K C; Tayler-Smith, K; Harries, A D

    2016-03-21

    Contexte : La prise en charge de la tuberculose (TB) pharmacorésistante au Viet Nam a bénéficié d'une accélération considérable depuis 2009.Objectifs : Documenter le nombre annuel de patients enrôlés pour un traitement de TB multirésistante (TB-MDR) entre 2010 et 2014, et déterminer les caractéristiques et les résultats du traitement des patients qui l'out commencé entre 2010 et 2012.Schéma : Etude rétrospective de cohorte basée sur les rapports nationaux et les données du système national de données électroniques pour la TB pharmacorésistante.Résultats : Le nombre de patients enrôlés chaque année pour traitement de TB-MDR a augmenté de 97 en 2010 à 1522 en 2014. La majorité des patients étaient des hommes d'âge moyen qui avaient une atteinte pulmonaire et chez qui un protocole de retraitement avait échoué ; 77% d'entre eux avaient reçu au moins deux traitements de TB. De bons résultats (guérison et achèvement du traitement) ont été obtenus chez 73% des patients. Les résultats défavorables incluaient les sujets perdus de vue (12,5%), les décès (8%) et les échecs (6,3%). Avoir eu plus de deux traitements préalables et être positif pour le virus de l'immunodéficience humaine étaient associés à des résultats défavorables.Conclusion : Un nombre croissant de patients est traité pour TB-MDR chaque année dans le cadre du programme national de prise en charge au Viet Nam, avec de bons résultats. Cependant, il est nécessaire d'augmenter la détection des cas (actuellement seulement 30% des 5100 cas de TB-MDR estimés par an), de réduire la proportion de résultats défavorables et d'améliorer le suivi et l'évaluation.

  12. Turmeric and Chinese goldthread synergistically inhibit prostate cancer cell proliferation and NF-kB signaling

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    Yi Zhao

    2014-07-01

    Full Text Available Background: Pre-clinical studies using bioactive compounds from botanicals appear to offer some protection against cancer. Research using single bioactives contributes greatly to our understanding of their mechanism of action, but in vitro studies demand concentrations that are higher than achievable in humans (µM. However, maintaining these bioactives in the presence of other compounds originally derived from the food or extract of origin may synergistically lower the bioactive dose so translatability becomes feasible. The objective of this study was to determine if bio-efficacy of phytonutrients can be enhanced when used in combination even at doses that are ineffective for any compound when used in isolation. Methods: The anti-proliferative and molecular effects of herbs (turmeric and Chinese goldthread and their bioactives (curcumin and ar-turmerone, berberine and coptisine, respectively were determined in isolation and in combination. Using CWR22Rv1 and HEK293 cells, cell proliferation (as assessed by the MTT assay and NF-κB promoter activity (using a luciferase reporter construct were evaluated and synergy of action was assessed by the ChouTalalay method utilizing CompuSyn® software. Results: Turmeric and Chinese goldthread act synergistically (combination index<1 when inhibiting cell proliferation with all cell lines tested. The synergy of action of combinations of companion bioactives from the same herb (i.e., curcumin/ar-turmerone and berberine/coptisine and bioactives from different herbs (i.e., curcumin/berberine help to explain why turmeric and Chinese goldthread are more effective than their major bioactives in isolation. At the molecule level, curcumin+ar-turmerone and curcumin+coptisine synergistically attenuated TNFα- stimulated NF-κB promoter activity. Even compounds with poor efficacy become more biologically active in the presence of companion compounds. Importantly, the effects of combining any two bioactives or herbal

  13. a Zero-Order Picture of the Infrared Spectrum for the Methoxy Radical: Assignment of States

    Science.gov (United States)

    Johnson, Britta; Sibert, Edwin

    2016-06-01

    The ground tilde{X}^2E vibrations of the methoxy radical have intrigued both experimentalists and theorists alike due to the presence of a conical intersection at the C3v molecular geometry. This conical intersection causes methoxy's vibrational spectrum to be strongly influenced by Jahn-Teller vibronic coupling which leads to large amplitude vibrations and extensive mixing of the two lowest electronic states. This coupling combined with spin-orbit and Fermi couplings greatly complicates the assignments of states. Using the potential force field and calculated spectra of Nagesh and Sibert1,2, we assign quantum numbers to the infrared spectrum. When the zero-order states are the diabatic normal mode states, there is sufficient mode mixing that the normal mode quantum numbers are poor labels for the final states. We define a series of zero-order Hamiltonians which include additional coupling elements beyond the normal mode picture but still allow for the assignment of Jahn-Teller quantum numbers. In methoxy, the two lowest frequency e} modes, the bend (q_5) and the rock (q_6), are the modes with the strongest Jahn-Teller coupling. In general, a zero-order Hamiltonian which includes first-order Jahn-Teller coupling in q_6 is sufficient for most states of interest. Working in a representation which includes first-order Jahn-Teller coupling in q_6, we identify states in which additional coupling elements must be included; these couplings include first-order Jahn-Teller coupling in q_5, higher order Jahn-Teller coupling in q_5 and q_6, and, in the dueterated case, Jahn-Teller coupling which is modulated by the corresponding a modes. [^1] Nagesh, J.; Sibert, E. L. J. Phys. Chem. A 2012, 116, 3846-3855. Lee, Y.F.; Chou, W.T.; Johnson, B.A.; Tabor, D.P. ; Sibert, E.L.; Lee, Y.P. J. Mol. Spectrosc. 2015, 310, 57-67. Barckholtz, T. A.; Miller, T. A. Int. Revs. in Phys. Chem. 1998, 17, 435-524.

  14. Synergistic activity of troxacitabine (Troxatyl™ and gemcitabine in pancreatic cancer

    Directory of Open Access Journals (Sweden)

    Leblond Lorraine

    2007-07-01

    Full Text Available Abstract Background Gemcitabine, a deoxycytidine nucleoside analog, is the current standard chemotherapy used as first-line treatment for patients with locally advanced or metastatic cancer of the pancreas, and extends life survival by 5.7 months. Advanced pancreatic cancer thus remains a highly unmet medical need and new therapeutic agents are required for this patient population. Troxacitabine (Troxatyl™ is the first unnatural L-nucleoside analog to show potent preclinical antitumor activity and is currently under clinical investigation. Troxacitabine was recently evaluated as a first-line therapy in 54 patients with advanced adenocarcinoma of the pancreas and gave comparable overall results to those reported with gemcitabine in recently published randomized trials. Methods The human pancreatic adenocarcinoma cell lines, AsPC-1, Capan-2, MIA PaCa-2 and Panc-1, were exposed to troxacitabine or gemcitabine alone or in combination, for 72 h, and the effects on cell growth were determined by electronic particle counting. Synergistic efficacy was determined by the isobologram and combination-index methods of Chou and Talalay. Mechanistic studies addressed incorporation of troxacitabine into DNA and intracellular levels of troxacitabine and gemcitabine metabolites. For in vivo studies, we evaluated the effect of both drugs, alone and in combination, on the growth of established human pancreatic (AsPC-1 tumors implanted subcutaneously in nude mice. Statistical analysis was calculated by a one-way ANOVA with Dunnett as a post-test and the two-tailed unpaired t test using GraphPad prism software. Results Synergy, evaluated using the CalcuSyn Software, was observed in all four cell-lines at multiple drug concentrations resulting in combination indices under 0.7 at Fa of 0.5 (50% reduction of cell growth. The effects of drug exposures on troxacitabine and gemcitabine nucleotide pools were analyzed, and although gemcitabine reduced phosphorylation of

  15. 未来事件交易所%TRADING FUTURES

    Institute of Scientific and Technical Information of China (English)

    王咏琳

    2012-01-01

    台北当代艺术中心(TCAC)由一群艺术家、策展人、学院学者与社会文化工作者于2010年2月在台北的城中区一处老旧公寓筹划成立,除了筹办展览、艺术家短期驻村、规划表演,也策划各式各样议题性讲座,在即将解散的时刻,他们推出最后一个文件展览——"未来事件交易所",借此提问艺术的呈现与过程究竟创造了什么?也借由这样的命题去探讨在劳动、社会价值、消费甚至是欲望经济的交错中,特别在资本主义驱动艺术世界交易的状况下,%Over Taipei Contemporary Art Center's (TCAC) two-year pilot period, in addition to organizing exhibitions, performances, and hosting short-term residencies, the minds be- hind TCAC have curated a wide variety of lec- tures. Now, on the eve of its relocation, they mounted the last exhibition and conceptual interrogation to take place on TCAC's found- ing campus. In "Trading Futures," TCAC asks, "What is ultimately created in the pro- cess of artmaking?" as a point of departure for exploring the ways in which art--infixed in this massive system at the intersection of labor, social values, consumerism, and even an economy of desire, especially in the con- text of capitalist art exchanges--maintains its independent kinetic energy and sustains its role in reversing the situation within such a huge system. "Trading Futures," co-curated by Meiya Cheng and Pauline J. Yao, invites artists Heman Chong, Yu-Cheng Chou, Minja Gu, Hu Xiangqian, Kao Jun-honn, Lee Kit,

  16. Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics

    Directory of Open Access Journals (Sweden)

    Liu L

    2013-04-01

    Full Text Available Lei Liu,1 Ying Ma,2 Run-Ling Wang,2 Wei-Ren Xu,3 Shu-Qing Wang,2,5 Kuo-Chen Chou4,5 1PET/CT Center, General Hospital of Tianjin Medical University, Tianjin, People’s Republic of China; 2Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics, School of Pharmacy, Tianjin Medical University, Tianjin, People’s Republic of China; 3Tianjin Institute of Pharmaceutical Research (TIPR, Tianjin, People’s Republic of China; 4Center of Excellence in Genomic Medicine Research (CEGMR, King Abdulaziz University, Jeddah, Saudi Arabia; 5Gordon Life Science Institute, Belmont, MA, USA Abstract: The high prevalence of type 2 diabetes mellitus in the world as well as the increasing reports about the adverse side effects of the existing diabetes treatment drugs have made developing new and effective drugs against the disease a very high priority. In this study, we report ten novel compounds found by targeting peroxisome proliferator-activated receptors (PPARs using virtual screening and core hopping approaches. PPARs have drawn increasing attention for developing novel drugs to treat diabetes due to their unique functions in regulating glucose, lipid, and cholesterol metabolism. The reported compounds are featured with dual functions, and hence belong to the category of dual agonists. Compared with the single PPAR agonists, the dual PPAR agonists, formed by combining the lipid benefit of PPARα agonists (such as fibrates and the glycemic advantages of the PPARγ agonists (such as thiazolidinediones, are much more powerful in treating diabetes because they can enhance metabolic effects while minimizing the side effects. This was observed in the studies on molecular dynamics simulations, as well as on absorption, distribution, metabolism, and excretion, that these novel dual agonists not only possessed the same function as ragaglitazar (an investigational drug developed by Novo Nordisk for treating type

  17. Entre conservation et développement : les évolutions récentes de la politique européenne des pêches dans les régions ultrapériphériques de la Caraïbe Between conservation and development: recent developments in European fisheries policy in the outermost regions of the Caribbean

    Directory of Open Access Journals (Sweden)

    Pierre Angelelli

    2012-05-01

    Full Text Available L’Union Européenne opère actuellement la seconde révision de sa politique de la pêche depuis la création de celle-ci, en 1970. Instituée pour développer la pêche maritime et garantir un revenu aux pêcheurs, la politique commune de la pêche (PCP s’est orientée progressivement vers la protection des espèces et de l’environnement marin. Pour cela, elle a sacrifié une part importante du secteur productif, mais a échoué et, avec le déclin de la pêche en Europe, les régions ultrapériphériques de la Caraïbe (RUP-C ont gagné en importance relative dans ce domaine. Elles représentent aujourd’hui près de 30% de la flotte nationale et les fondements malthusiens de la PCP ne sont plus adaptés à leurs caractéristiques : ressources halieutiques, développement économique, emplois, sécurité des approvisionnements alimentaires, etc. La réforme actuellement en cours, qui devrait aboutir avant 2012, offre peut-être une alternative aux RUP-C permettant la mise en œuvre des mesures spécifiques en application de l’article 349 du Traité sur le Fonctionnement de l’Union Européenne.The European Union currently operates the second reform of its Common Fisheries Policy since its creation in 1970. Established to develop the fisheries and provide incomes for fishermen, the Common Fisheries Policy (CFP was directed gradually towards the protection of the species and the marine environment.To do this, it sacrificed a large part of the productive sector, but failed, and with the decline of fisheries in Europe, the outermost regions of the Caribbean gained relative importance in this field. They now account for nearly 30% of the national fleet and the Malthusians bases of the CFP are not suited any more to their characteristics: fisheries resources, economic development, jobs, security of food supply, etc. The ongoing reform, which should be in force before 2012, may offer an alternative to the outermost regions of the Caribbean

  18. Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells.

    Science.gov (United States)

    Klimaszewska-Wisniewska, Anna; Halas-Wisniewska, Marta; Tadrowski, Tadeusz; Gagat, Maciej; Grzanka, Dariusz; Grzanka, Alina

    2016-01-01

    The use of the dietary polyphenols as chemosensitizing agents to enhance the efficacy of conventional cytostatic drugs has recently gained the attention of scientists and clinicians as a plausible approach for overcoming the limitations of chemotherapy (e.g. drug resistance and cytotoxicity). The aim of this study was to investigate whether a naturally occurring diet-based flavonoid, fisetin, at physiologically attainable concentrations, could act synergistically with clinically achievable doses of paclitaxel to produce growth inhibitory and/or pro-death effects on A549 non-small cell lung cancer cells, and if it does, what mechanisms might be involved. The drug-drug interactions were analyzed based on the combination index method of Chou and Talalay and the data from MTT assays. To provide some insights into the mechanism underlying the synergistic action of fisetin and paclitaxel, selected morphological, biochemical and molecular parameters were examined, including the morphology of cell nuclei and mitotic spindles, the pattern of LC3-II immunostaining, the formation of autophagic vacuoles at the electron and fluorescence microscopic level, the disruption of cell membrane asymmetry/integrity, cell cycle progression and the expression level of LC3-II, Bax, Bcl-2 and caspase-3 mRNA. Here, we reported the first experimental evidence for the existence of synergism between fisetin and paclitaxel in the in vitro model of non-small cell lung cancer. This synergism was, at least partially, ascribed to the induction of mitotic catastrophe. The switch from the cytoprotective autophagy to the autophagic cell death was also implicated in the mechanism of the synergistic action of fisetin and paclitaxel in the A549 cells. In addition, we revealed that the synergism between fisetin and paclitaxel was cell line-specific as well as that fisetin synergizes with arsenic trioxide, but not with mitoxantrone and methotrexate in the A549 cells. Our results provide rationale for

  19. Experimental Realizations of Magnetic Topological Insulator and Topological Crystalline Insulator

    Science.gov (United States)

    Xu, Suyang

    2013-03-01

    . Gibson, R. Sankar, Y.J. Wang, T. Chang, H. Jeng, H. Lin, L.A. Wray, J.D. Denlinger, M. Leandersson, T. Balasubramanian, J. Sánchez-Barriga, O. Rader, G. Landolt, B. Slomski, J.H. Dil, F.C. Chou, E. Morosan, N. Samarth, R.J. Cava and M.Z. Hasan. This work is primarily supported by U.S. DOE grant DE-FG-02-05ER46200.

  20. Inversion of single-station teleseismic P-wave polarization-data for the velocity structure of Beijing area

    Institute of Scientific and Technical Information of China (English)

    LIU; Futian; (

    2001-01-01

    [1]Pavlis, G. L., Booker, J. R., Progressive multiple event location (PMEL), Bull. Seismol. Soc. Am., 1983, 73: 1753.[2]Dziewonski, A. M., Anderson, D. L., Travel times and station corrections for P-waves at teleseismic distances, J. Geophys. Res., 1983, 88: 3295.[3]Hu Ge, Menke, W., Formal inversion of laterally heterogeneous velocity structure from P-wave polarization data, Geophys. J. Int., 1992. 110: 63.[4]Menke, W., Lerner-Lam, A., Transition from linear to complex polarization in short period compressional waves, Bull. Seismol. Soc. Am., 1991, 81: 611.[5]Hu Ge, Menke, W., Rognvaldsson, S., A demonstration of the joint use of p-wave polarization and travel-time data in tomographic inversion: crustal velocity structure near the south Iceland Lowland network, Geophys. Res. Letters, 1993, 20(13): 1407.[6]Teng, J., Yao, H., Chou, H., Crustal structure in the Beijing-Tianjin-Tangshan-Zhangjiakou region, Acta Geophysica Sinica(in Chinese), 1979, 22(3): 218.[7]Shao, X., Zhang, J., Chen, X. et al., The results of deep sounding by using converted waves of earthquakes in the Beijing-Tianjin-Tangshan region, Seismology and Geology(in Chinese), 1980: 2(2): 12.[8]Wei, M., Shi, Z., Yin, X. et al., The basic configuration of crustal structure in North China region and its relation to the earthquakes from gravimetric date, Seismology and Geology(in Chinese), 1980, 2(2): 55.[9]Jin Anshu, Liu Futian, Sun Yongzhi, Three-dimensional P velocity structure of the crust and upper Mantle under Beijing region, Acta Geophysica Sinica(in Chinese), 1980, 23(2): 172.[10]Vidale, J.E., Complex polarization analysis of particle motion, Bull. Seismol. Soc. Am., 1986, 76: 1393.[11]Jurkevics, A., Polarization analysis of three-component array data, Bull, Seismol. Soc. Am., 1988, 78: 1725.[12]Park, J., Vernon, F. L., Lindberg, C.R., Frequency dependent polarization analysis of high-frequency seismograms, J. Geophys. Res., 1987, 92: 12664.[13

  1. Autoantibody profiling in systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Hsieh SC

    2013-08-01

    Full Text Available Song-Chou Hsieh,1 Chia-Li Yu1,2 1Department of Internal Medicine, 2Institute of Molecular Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Abstract: Systemic lupus erythematosus (SLE is an archetype of systemic autoimmune disease characterized by the production of a broad spectrum of autoantibodies. More than 100 autoantibodies have been found in the sera of patients with SLE, including antibodies against nuclear, cytoplasmic, surface-membrane, and extracellular antigens. There has been considerable debate as to whether these antinuclear autoantibodies (ANAs are merely biomarkers for disease or are responsible for organ/tissue damage in SLE. In recent years, sufficient evidence has supported the hypothesis that many ANAs, such as anti-double-stranded DNA (anti-dsDNA, antiribosomal P, anti-Sm, antiribonucleoprotein (anti-RNP, and even anti-Sjögren's syndrome (SS-B/La antibodies not only act against specific nuclear antigens but also cross-react with different surface-expressed cognate molecules. The binding of autoantibodies to the cell surface leads to their penetration into the cell's interior to elicit cellular damage. There are at least four conceivable routes for ANAs to penetrate the cytoplasm: (1 nonspecific Fcγ receptor-mediated uptake, (2 cell-surface caveolae-mediated endocytosis, (3 electrostatic interactions between positively charged amino acids of the complementarity-determining regions of the antibody molecule and the negatively charged surface membrane, and (4 the binding of the autoantibody with its cross-reactive cell surface-expressed cognate molecule, and its subsequent endocytosis into the cytoplasm. In this review, we discuss in detail the immunopathogenic mechanisms of the commonly encountered ANAs, such as anti-dsDNA, antiribosomal P, and anti-SSB/La, that are associated with lupus pathogenesis. Additionally, the detrimental thromboembolism-inducing anticardiolipin antibodies in patients with SLE

  2. Dental prophylaxis decreases the risk of acute myocardial infarction: a nationwide population-based study in Taiwan

    Directory of Open Access Journals (Sweden)

    Lee YL

    2015-01-01

    Full Text Available Ya-Ling Lee,1,2 Hsiao-Yun Hu,2,3 Pesus Chou,2 Dachen Chu2,4,5 1Department of Dentistry, Taipei City Hospital, 2Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, 3Department of Education and Research, Taipei City Hospital, 4Department of Health Care Management, National Taipei University of Nursing and Health Sciences, 5Department of Neurosurgery, Taipei City Hospital, Taipei, Taiwan Purpose: To investigate the association between periodontal disease (PD and acute ­myocardial infarction (AMI, and evaluate the effect of dental prophylaxis on the incidence rate (IR of AMI.Methods: The Longitudinal Health Insurance Database 2000 from the National Health Insurance program was used to identify 511,630 patients with PD and 208,713 without PD during 2000–2010. Subjects with PD were grouped according to treatment (dental prophylaxis, intensive treatment, and PD without treatment. The IRs of AMI during the 10-year follow-up period were compared among groups. Cox regression analysis adjusted for age, sex, socioeconomic status, residential urbanicity, and comorbidities was used to evaluate the effect of PD treatment on the incidence of AMI.Results: The IR of AMI among subjects without PD was 0.19%/year. Among those with PD, the IR of AMI was lowest in the dental prophylaxis group (0.11%/year, followed by the intensive treatment (0.28%/year and PD without treatment (0.31%/year; P<0.001 groups. Cox regression showed that the hazard ratio (HR for AMI was significantly lower in the dental prophylaxis group (HR =0.90, 95% confidence interval =0.86–0.95 and higher in the intensive treatment (HR =1.09, 95% confidence interval =1.03–1.15 and PD without treatment (HR =1.23, 95% confidence interval =1.13–1.35 groups than in subjects without PD.Conclusion: PD is associated with a higher risk of AMI, which can be reduced by dental prophylaxis to maintain periodontal health. Keywords: periodontal disease

  3. 基于神经网络集成方法预测膜蛋白类型%Prediction of Membrane Protein Types Based on Neural Network Ensemble Strategy

    Institute of Scientific and Technical Information of China (English)

    方海洋; 赵静; 汪益川; 宗福兴

    2013-01-01

    由Chou等人提出的预测膜蛋白分类的机器学习算法在近年来不断改进,使得预测膜蛋白类型的准确率越来越高。但是由于膜蛋白类分布不均衡而导致少数类的预测准确率非常低,使用神经网络集成方法能解决此问题。该方法中Bagging算法通过对多数类欠采样和少数类过采样来解决膜蛋白训练数据集不均衡问题。此外,用神经网络集成方法对已训练数据集和独立数据集进行分类测试,得出神经网络集成方法预测效果优于单个最好神经网络。该方法为解决蛋白质分类预测问题提供了一种新的策略,特别是训练数据集不均衡时,该方法的优势更加明显。%As a continuous effort to develop machine learning algorithms to predict membrane protein types that was initiated by Chou and Elrod,this study focuses on dealing with the problem of imbalanced training set of membrane protein types with the neural network ensemble. Bagging algorithm of the neural network ensemble has the advantage of dealing with imbalanced training set of membrane protein types by over-sampling minority classes and under-sampling majority classes. Furthermore,the perfor-mance of the neural network ensemble is found to be superior to the single best model from the results obtained through resubstitu-tion and independent dataset tests. The current approach represents a new strategy to deal with the problems of protein attribute pre-diction,especially when the training set is imbalanced,and hence is quite promising in the area of proteomics.

  4. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2005-01-01

    Full Text Available Peter Borschberg (ed., Iberians in the Singapore-Melaka area and adjacent regions (16th to 18th century (Syed Muhd Khairudin Aljunied Katharine L. Wiegele, Investing in miracles; El Shaddai and the transformation of popular Catholicism in the Philippines (Greg Bankoff Jean Gelman Taylor, Indonesia; Peoples and histories (Peter Boomgaard Clive Moore, New Guinea; Crossing boundaries and history (Harold Brookfield Nathan Porath, When the bird flies; Shamanic therapy and the maintenance of worldly boundaries among an indigenous people of Riau (Sumatra (Cynthia Chou and Martin Platt Paul van der Grijp, Identity and development; Tongan culture, agriculture, and the perenniality of the gift (H.J.M. Claessen Tim Bunnell, Malaysia, modernity and the multimedia super corridor; A critical geography of intelligent landscapes (Ben Derudder L. Fontijne, Guardians of the land in Kelimado; Louis Fontijne’s study of a colonial district in eastern Indonesia (Maribeth Erb Karl-Heinz Golzio, Geschichte Kambodschas; Das Land der Khmer von Angkor bis zur Gegenwart (Volker Grabowsky Emmanuel Poisson, Mandarins et subalternes au nord du Viêt Nam; Une bureaucracie à l’épreuve (1820-1918 (Martin Grossheim Generale Missiven van Gouverneurs-Generaal en Raden aan Heren XVII der Verenigde Oostindische Compagnie, Volume 10, 1737-1743 (Gerrit Knaap Aris Ananta and Evi Nurvidya Arifin (eds, International migration in Southeast Asia (Santo Koesoebjono Vladimir Braginsky, The comparative study of traditional Asian literatures; From reflective traditionalism to neo-traditionalism (G.L. Koster Fiona Kerlogue (ed., Performing objects; Museums, material culture and performance in Southeast Asia (Jennifer Lindsay Th.C. van der Meij, Puspakrema; A Javanese romance from Lombok (Julian Millie Robyn Maxwell, Sari to sarong; Five hundred years of Indian and Indonesian textile exchange -- Jasleen Dhamija, Woven magic; The affinity between

  5. Effects of primary caregiver participation in vestibular rehabilitation for unilateral neglect patients with right hemispheric stroke: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Dai CY

    2013-04-01

    Full Text Available Chin-Ying Dai,1,2 Yu-Hui Huang,3,4 Li-Wei Chou,5,6 Shiao-Chi Wu,7 Ray-Yau Wang,8 Li-Chan Lin9 1School of Nursing, National Yang Ming University, Taipei, Taiwan; 2Department of Nursing, Central Taiwan University of Science and Technology, Taichung, Taiwan; 3Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung, Taiwan; 4School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 5Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 6School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 7Institute of Health and Welfare Policy, National Yang-Ming University, Taipei, Taiwan; 8Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan; 9Institute of Clinical and Community Health Nursing, National Yang-Ming University, Taipei, Taiwan, Republic of China Introduction: The current study aims to investigate the effects of primary caregiver participation in vestibular rehabilitation (VR on improving the measures of neglect, activities of daily living (ADL, balance, and falls of unilateral neglect (UN patients. Methods: This study is a single-blind randomized controlled trial. Both experimental (n = 24 and control groups (n = 24 received conventional rehabilitation. The experimental group undertook VR for a month. During the first and second weeks, a registered nurse trained the experimental group in VR. The primary caregivers in the experimental group supervised and guided their patients in VR during the third and fourth weeks. The outcome measures were neglect, ADL, balance, and falls. Results: The two groups of UN patients showed a significant improvement in neglect, ADL, and balance over time. Based on the generalized estimating equations model, an interaction was observed between groups and times. Significant interactions were observed between the VR group

  6. An interactive game-based shoulder wheel system for rehabilitation

    Directory of Open Access Journals (Sweden)

    Chou LW

    2012-11-01

    Full Text Available Chun-Ming Chang,1,* Yen-Ching Chang,2,3 Hsiao-Yun Chang,4 Li-Wei Chou5,6,* 1Department of Applied Informatics and Multimedia, Asia University, Taichung, Taiwan; 2Department of Medical Informatics, Chung Shan Medical University, Taichung, Taiwan; 3Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan; 4Department of Biotechnology, Asia University, Taichung, Taiwan; 5Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 6School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan*These authors contributed equally to this workBackground: Increases in the aging population and in the number of accidents have resulted in more people suffering from physical impairments or disabilities. Rehabilitation therapy thus attracts greater attention as a means of helping patients recover and return to a normal life. With the extremely long and tedious nature of traditional rehabilitation, patients are reluctant to continue the entire process, thus the expected effects of the therapy cannot be obtained. Games are well known to help patients improve their concentration and shift their attention away from the discomfort of their injuries during rehabilitation. Thus, incorporating game technology into a rehabilitation program may be a promising approach.Methods: In this study, a gaming system used for shoulder rehabilitation was developed. The mechanical parts and electric circuits were integrated to mimic the functionalities of a shoulder wheel. Several games were also designed to suit the rehabilitation needs of the patients based on the age and gender differences among the individual users, enabling individuals to undergo the rehabilitation process by playing games. Two surveys were conducted to evaluate the satisfaction of the participants regarding the gaming system.Results: The results of the online survey among a larger population

  7. Sharing a bowl of tea.

    Science.gov (United States)

    Sen, S

    1993-06-01

    Soshitsu Sen's keynote speech before a symposium on population and the environment is summarized unofficially by the editorial staff. The instability of human thinking is given as the cause for the present destruction of the environment. In a visit to the His Majesty King of Sweden, Sen remarked that stabilizing human minds can be achieved within the tea ceremony through "serving tea heartily, receiving it with gratitude, and offering it to another." In this way, the spirit of concern for others can be practiced in everyday life and tranquility of mind reached. News broadcasts of starving parents and children as victims of civil war are disheartening. The Japanese people are not suffering such hunger, even though the economy has not been as robust as desired. The analogy is provided in the story by Chuang Chou about King Hun Dun and King Xiu and man's good intentions, which nonetheless destroy the earth. Japan has experienced forest and environmental destruction on the road to economic prosperity and satisfaction of self-interests. The advice on living in accord with nature is to appreciate each season for its own changes. For example, when it is the winter season, the complaint is about the cold and the desire is for spring; but when spring comes, the desire is for the cooler weather of fall. the ordinary way is to appreciate all seasons and is the best way of sustaining a healthy environment. In the garden of the tea hut, humans enter without their worldly title, position, and means; at the water basin, hands and mouth are cleansed, and entrance is made through a small hole into the hut much the same as emerging from the womb. Worldly matters are dispensed with and purity of thought is shared in the sharing of the bowl of green tea, saying "after you" to one another. Christianity and the Way of Tea share the same symbols of purification. The black tea bowl is in harmony with the green tea. Fatigue is relieved when gazing upon the color green; examples are given

  8. Role of physiotherapy and patient education in lymphedema control following breast cancer surgery

    Directory of Open Access Journals (Sweden)

    Lu SR

    2015-02-01

    Full Text Available Shiang-Ru Lu,1 Rong-Bin Hong,2 Willy Chou,3,4 Pei-Chi Hsiao3,4 1Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 2Departments of Physical Medicine and Rehabilitation, Chi-Mei Medical Center Liouying Campus, Tainan, Taiwan; 3Department of Physical Medicine and Rehabilitation, Chi-Mei Medical Center, Tainan, Taiwan; 4Department of Recreation and Health Care Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan Introduction: This retrospective cohort study evaluated whether education in combination with physiotherapy can reduce the risk of breast cancer-related lymphedema (BCRL. Methods: We analyzed 1,217 women diagnosed with unilateral breast cancer between January 2007 and December 2011 who underwent tumor resection and axillary lymph node dissection. The patients were divided into three groups: Group A (n=415, who received neither education nor physiotherapy postsurgery; Group B (n=672, who received an educational program on BCRL between Days 0 and 7 postsurgery; and Group C (n=130, who received an educational program on BCRL between Days 0 and 7 postsurgery, followed by a physiotherapy program. All patients were monitored until October 2013 to determine whether BCRL developed. BCRL risk factors were evaluated using Cox proportional hazards models. Results: During the follow-up, 188 patients (15.4% developed lymphedema, including 77 (18.6% in Group A, 101 (15.0% in Group B, and 10 (7.7% in Group C (P=0.010. The median period from surgery to lymphedema was 0.54 years (interquartile range =0.18–1.78. The independent risk factors for BCRL included positive axillary lymph node invasion, a higher (>20 number of dissected axillary lymph nodes, and having undergone radiation therapy, whereas receiving an educational program followed by physiotherapy was a protective factor against BCRL (hazard ratio =0.35, 95% confidence interval =0.18–0.67, P=0.002. Conclusion: Patient education that begins

  9. Effectiveness of a heel cup with an arch support insole on the standing balance of the elderly

    Directory of Open Access Journals (Sweden)

    Chen TH

    2014-02-01

    Full Text Available Tzu-Hsuan Chen,1,* Li-Wei Chou,2,3,* Mei-Wun Tsai,4 Ming-Jor Lo,5 Mu-Jung Kao4,5 1Department of Rehabilitation, Mackay Memorial Hospital, Hsinchu, Taiwan; 2Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan; 3School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 4Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan; 5Department of Rehabilitation, Yangming Branch, Taipei City Hospital, Taipei, Taiwan *These authors contributed equally to this paper Background: The use of insoles may enhance postural stability and prevent falls. The aim of this study was to design a new insole and to explore the effectiveness of the insole on the standing balance of the healthy elderly. Methods: The study was conducted at a community hospital. Patients older than 65 years at an outpatient clinic without abnormal gait patterns, lower limb deformities, or foot pain were enrolled. The participants were assigned to good- and poor-stability groups on the basis of the stability index (SI, using the Biodex® Balance System. A heel cup with an arch support insole was provided. Participants wore the insole for 8 weeks for a minimum of 4 hours/day. A static balance test for SI was performed at the initial meeting and 8 weeks after the assigned insoles were worn for each participant. Results: Five participants (10.0% of 50 total did not finish the study. There were 25 patients in the good-stability group and 20 in the poor-stability group. The SI, before and after intervention, was significantly different for all 45 participants (3.244±0.688 versus 3.064±0.671; P<0.001. The differences in SI before and after the intervention both in the good-stability group (2.764±0.546 versus 2.592±0.538 and the poor-stability group (3.845±0.188 versus 3.655±0.128 were statistically significant (P<0.001. No statistically significant

  10. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pharmacology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pharmacology”ABS 1. BABY SKIN CARE PRODUCTS • P. Doro, R. Abraham, D. Agoston, J. Balog, R.Z. CsomaABS 2. MATHEMATICAL MODELING TO PREDICT IN-HOSPITAL NATURAL WEIGHT CHANGES IN TERM NEONATES • S. Kasser, M. Wilbaux, C. De Angelis, H. Rickenbacher, N. Klarer, J.N. Van Den Anker, M. Pfister, S. WellmannABS 3. IMPROVING PARENTERAL NUTRITION IN THE NEONATE – A PRACTICAL GUIDELINE • H. Reigstad, D. Moster, I. Grønlie, A. BlystadABS 4. INVOLUTION OF RETINOPATHY OF PREMATURITY AND NEURODEVELOPMENTAL OUTCOME AFTER BEVACIZUMAB TREATMENT • Y.-S. Chang, P.-N. Tsao, C.-Y. Chen, H.-C. Chou, W.-S. Hsieh, P.-T. YehABS 5. RELATIONSHIP BETWEEN ADVERSE DRUG REACTIONS AND OFF-LABEL/UNLICENSED DRUG USE IN HOSPITALISED CHILDREN. EREMI STUDY • K.A. Nguyen, Y. Mimouni, A. Lajoinie, N. Paret, S. Malik, L. El-Amrani, L. Milliat-Guittard, C. Carcel, A. Portefaix, A.M. Schott, T. Vial, B. KassaiABS 6. A SYSTEMATIC REVIEW OF OFF-LABEL AND UNLICENSED DRUGS USE AND ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN • N. David, K.A. Nguyen, Y. Mimouni, A. Lajoinie, S. Malik, B. KassaiABS 7. EFFICACY AND SAFETY OF PROPOFOL SEDATION

  11. Book Reviews

    Directory of Open Access Journals (Sweden)

    Chanatip Kesavadhana

    2000-01-01

    Full Text Available - A.S. Baer, Philip Houghton, People of the Great Ocean; Aspects of human biology of the early Pacific. Cambridge: Cambridge University Press, 1996, x + 292 pp. - Greg Bankoff, Vicente L. Rafael, Figures of criminality in Indonesia, the Philippines, and colonial Vietnam. Ithaca, NY: Cornell University Southeast Asis Program, 1999, 258 pp. - Harold Brookfield, Donald Denoon, The Cambridge history of the Pacific Islanders. Cambridge: Cambridge University Press, 1997, xvi + 518 pp., Stewart Firth, Jocelyn Linnekin (eds. - Cynthia Chou, Shoma Munshi, Clifford Sather, The Bajau Laut; Adaptation, history, and fate in a maritime fishing society of south-eastern Sabah. Kuala Lumpur: Oxford University Press, 1997, xviii + 359 pp. - Cynthia Chou, Shoma Munshi, Krishna Sen, Gender and power in affluent Asia. London: Routledge, 1998, xiii + 323 pp., Maila Stivens (eds. - Freek Colombijn, Arne Kalland, Environmental movements in Asia. Richmond, Surrey: Curzon, 1998, xiii + 296 pp. [Nordic Institute of Asian Studies, Man and Nature in Asia Series 4.], Gerard Persoon (eds. - Kirsten W. Endres, Phan Huy Chu, Hai trinh chi luoc; Récit sommaire d’un voyage en mer (1833; Un émissaire Vietnamien à Batavia. Paris: EHESS, 1994, viii + 228 pp. [Cahier d’Archipel 25.] - Aone van Engelenhoven, Veronica Du Feu, Rapanui. London: Routledge, 1996, xv + 217 pp. [Routledge Descriptive Grammars.] - Fukui Hayao, Peter Boomgard, Paper landscapes; Explorations in the environmental history of Indonesia, 1997, vi + 424 pp. Leiden: KITLV Press. [Verhandelingen 178.], Freek Colombijn, David Henley (eds. - Volker Heeschen, J. Miedema, Texts from the oral tradition in the south-western Bird’s Head Peninsula of Irian Jaya; Teminabuan and hinterland. Leiden: DSALCUL, Jakarta: ISIR, 1995, vi + 98 pp. [Irian Jaya Source Materials 14.] - Volker Heeschen, J. Miedema, Texts from the oral tradition in the southern Bird’s Head Peninsula of Irian Jaya; Inanwatan-Berau, Arandai

  12. Immersion freezing by SnomaxTM particles: Comparison of results from different instruments

    Science.gov (United States)

    Wex, Heike; Stratmann, Frank; Rösch, Michael; Niedermeier, Dennis; Nilius, Björn; Möhler, Ottmar; Mitra, Subir K.; Koop, Thomas; Jantsch, Evelyn; Hiranuma, Naruki; Diehl, Karoline; Curtius, Joachim; Budke, Carsten; Boose, Yvonne; Augustin, Stefanie

    2014-05-01

    Within the DFG funded research unit INUIT (Ice Nucleation research UnIT, FOR 1525), an effort was made to compare results on immersion freezing from a suite of different instruments. Besides mineral dusts, SnomaxTM was picked as one of the substances that were examined by all participating groups. Here, the comparison of the results for SnomaxTM is presented. Every participating group used SnomaxTM from the same batch and, as far as possible, the same particle generation set-up. Instruments participating in the comparison were, in alphabetical order, an acoustic levitator (Diehl et al., 2009), AIDA (Connolly et al., 2009), BINARY (Budke et al., 2013), FINCH (Bundke et al., 2008), LACIS (Hartmann et al., 2011), PINC (Chou et al., 2011) and the Mainz vertical windtunnel (Diehl et al., 2011). Some of the instruments examined droplets directly produced from SnomaxTM suspensions, where the suspensions could have a wide range of concentrations. Other instruments used size segregated particles which were generated via atomization from a SnomaxTM suspension and subsequent drying, followed by size selection with a DMA (Differential Mobility Analyzer). These particles were then activated to droplets and cooled subsequently. For these, the number of ice nucleation active protein complexes present in the droplets depended on the original particle size (for details see e.g. Hartmann et al., 2013). Also, the different measurements spanned a range of different time scales. The shortest residence time of roughly 1 second was used for LACIS measurements, and the longest one was about 6 seconds used in the BINARY setup with a cooling rate of 1 K/min. All data were evaluated using two different approaches: 1) a time dependent approach following Classical Nucleation Theory which included the use of a contact angle distribution (see Niedermeier et al., 2014); 2) a singular approach using an active site density per mass (see Vali, 1971, Murray et al., 2012). Both approaches were found

  13. 沙蒿木蠹蛾生物学特性研究%Bionomics of the sand sagebrush carpenterworm, Holcocerus artemisiae (Lepidoptera: Cossidae)

    Institute of Scientific and Technical Information of China (English)

    王建伟; 骆有庆; 宗世祥

    2011-01-01

    沙蒿木蠹蛾Holcocerus artemisiae Chou et Hua是危害油蒿Artemisia ordosica Krasch和籽蒿A.sphaerocephala Krasch的重要钻蛀性害虫,以幼虫蛀食根部,导致寄主植物长势衰弱甚至死亡.为有效控制其危害,我们对该虫形态和生物学特征结合野外调查和室内饲养观察进行了研究.结果表明:在宁夏,该虫2年发生1代,以幼虫在被害油蒿根部越冬;老熟幼虫于5月中旬从受害根部钻出,在周围的沙土里结茧化蛹,蛹期平均19.5±3.5 d;成虫始见于6月初,终见于8月末,期间经历3次羽化高峰,分别为6,7,8月的上旬.成虫羽化主要在14:00-17:00,整个过程持续30~45 min;羽化当日即可交配,交配时间为20:00-21:00,高峰期为20:30左右;雄虫有2次交尾现象.雄虫寿命2~3 d,雌虫寿命1~3 d,极少4 d.雌雄性比约为1∶2.16.卵初见于6月中旬,初孵幼虫初见于6月下旬.幼虫常单独危害,且具有转移危害的习性,蛀食坑道不规则.5-9月,油蒿受害率为11%~44%,平均24%,株虫口密度为0.13头/株.幼虫对油蒿的树龄和地径有较明显的选择性,主要危害1~4年生、地径16~34mm的油蒿.沙蒿木蠹蛾生物学特征的系统研究为其控制措施的制定提供了科学依据.%The sand sagebrush carpenterworm, Holcocerus artemisiae Chou et Hua, is a severe pest of Artemisia ordosica and A.sphaerocephala, with the larval stages boring into the roots of the host plants.Morphological and biological characteristics of H.artemisiae in Ningxia were studied through field survey and laboratory breeding and observation.The results showed that a generation takes two years in fields of Ningxia.Larvae of all instars were found to overwinter in the host plant roots.Mature larvae begin to pupate in mid May in the soil around the base of plant stems, with the average pupal stage lasting 19.5 ±3.5 d.Moths emerge from the beginning of June to the end of August, with three peaks of eclosion observed in the early June

  14. DHA 联合5-FU 对人胃癌细胞增殖的抑制及线粒体呼吸链膜蛋白复合体的表达变化%The effect of combination of docosahexaenoic acid and 5-fluorouracil on the proliferation of human gastric cancer cell line AGS and the expression of mitochondrial respiratory membrane protein complexes

    Institute of Scientific and Technical Information of China (English)

    王曙逢; 赵志浩; 刘竹君; 高琨; 李幼芬

    2015-01-01

    Objective To investigate the inhibitory effects of docosahexaenoic acid (DHA)and 5-fluorouracil (5-FU)in combination on human gastric cancer cell line AGS in vitro .Methods Human gastric cancer line AGS was treated with different concentrations of DHA and 5-FU alone or in combination.The inhibition of cell proliferation was evaluated by MTT assay.Dose of median (IC50 )of drugs (alone or in combination)and the combination index (CI)were calculated using the median-effect equation and the combination index equation of Chou-Talalay.Flow cytometry was used to detect the cell cycle distribution.The expression of mitochondrial respiratory membrane protein complex in AGS cells was analyzed with Western blot.Results DHA and 5-FU alone or in combination could markedly suppress the proliferation of AGS in significantly time-dependent and dose-dependent manners (P <0.05).IC50 values with DHA or 5-FU administered for 24 h and 48 h were 5 1.60 μg/mL (DHA:24 h),34.82 μg/mL (DHA:48 h),45.90 μg/mL (5-FU:24 h),and 1 6.86 μg/mL (5-FU:48 h), respectively.DHA remarkably strengthened the inhibitory effect of 5-FU and decreased IC50 of 5-FU by 3.56 -2.1 5 folds.The combination of DHA and 5-FU showed synergism.Flow cytometry showed that AGS cells treated with DHA and 5-FU were arrested in G0/G1 phase and the proportion of AGS cells in G0/G1 phase increased compared with that in the control group,DHA group and 5-FU group,while the proportion of the cells in S phase decreased significantly (P < 0.05 ).Western blot showed after treatment with DHA and 5-FU for 48 h,the expression of mitochondrial respiratory membrane protein complex was significantly decreased compared with control group,DHA group and 5-FU group (P <0.05).Conclusion DHA could act synergistically with 5-FU in inhibiting the growth of gastric carcinoma cells,and meanwhile decrease the dose of 5-FU.The mechanism may be associated with cell cycle arrest in G0/G1 phase and interference in the energy metabolism of AGS cells

  15. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Lung and development”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    ñambres Rodríguez, A. Pino Vázquez, M. Brezmes Raposo, C. Fernández Garcia-Abril, C. Villa FranciscoABS 12. THE GESTATIONAL EFFECT OF ANTENATAL CORTICOSTEROIDS ON RESPIRATORY DISTRESS SYNDROME IN VERY LOW BIRTH WEIGHT INFANTS: A POPULATION BASED STUDY • S.Y. Liu, H.I. Yang, H.C. Chou, C.Y. Chen, W.S. Hsieh, K.I. Tsou, P.N. TsaoABS 13. PREECLAMPSIA AND THE RISK OF RESPIRATORY DISTRESS SYNDROME IN VLBW INFANTS: A POPULATION BASED STUDY • Y.H. Wen, H.I. Yang, W.S. Hsieh, H.C. Chou, C.Y. Chen, K.I. Tsou, P.N. TsaoABS 14. EFFECTIVENESS OF SINGLE DOSE SALBUTAMOL NEBULIZATION IN THE TREATMENT OF TRANSIENT TACHYPNEA OF THE NEWBORN: A DOUBLE BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL • M.L.B. Cruz, M.J.C. Racoma, V.O.M. Cloma-Rosales, M.V.J. CabahugABS 15. COMPARING THERAPEUTIC IMPACT OF BUBBLE CPAP WITH VARIABLE CPAP IN PREMATURE INFANT WITH RESPIRATORY DISTRESS • M. Noorishadkam, M.H. Lokzade, M. Eslami-Abrandabadi, E. Abbasi ShavaziABS 16. THE INCIDENCE OF RESPIRATORY MORBIDITY IN LATE PRETERM INFANT • G. Olariu, S. Olariu, M. TunescuABS 17. HYDROCORTISONE IN PRETERM INFANTS • C. Ramos-Navarro, M. Tomé-Perez, M. R. Ruiz-Gutierrez, S. Zeballos-Sarrato, N. Navarro-Patiño, I. Pescador-Chamorro, A. Rodriguez-De la Blanca, I. Marsinyach-Ross, M. Arriaga-Redondo, M. Sánchez-LunaABS 18. THE VALUE OF ULTRASOUND EXAMINATION IN PREDICTING CHRONIC LUNG DISEASE IN VLBW INFANTS UNDERGOING RESPIRATORY SUPPORT: PRELIMINARY RESULTS • S. Aversa, C. Zambelloni, R. Marzollo, V. Materia, F. Matina, G. ChiricoABS 19. RESPIRATORY DISTRESS OUTCOME AFTER SURFACTANT TREATMENT IN PREMATURE NEONATES OF LESS THAN 28 WEEKS OF GESTATION • M. Matyas1, L. Blaga, M. Hășmășanu, V. Obada, G. ZaharieABS 20. METABOLOMICS ANALYSIS ON THE BALF OF PRETERM INFANTS WITH A GESTATIONAL AGE LESS THAN 30 WEEKS TO IDENTIFY NEW BIOMARKERS OF BPD • F. Piersigilli, M. Syed, A. Dotta, C. Auriti, G. Salvatori, P. Vernocchi, E. Voss, T. Lam, V. BhandariABS 21. VENTILATOR-ASSOCIATED PNEUMONIA IN A NEONATAL

  16. Le national-populisme roumain aux portes de Bruxelles

    Directory of Open Access Journals (Sweden)

    Sorina Soare

    2005-09-01

    Full Text Available Le national-populisme marque visiblement le paysage politique roumain, mais c’est surtout le Parti de la Grande Roumanie, devenu récemment le Parti Populaire de la Grande Roumanie, qui réussit à s’assurer une constance électorale. Malgré ses résultats électoraux, son potentiel de coalition est complètement ignoré par tous les partis parlementaires roumains. D’ailleurs, le cordon sanitaire qui l’isole depuis 1996 assure indirectement la stabilité de la démocratie roumaine. Comment appréhender alors le national-populisme roumain ? L’article propose une interprétation socio-historique qui met en évidence le caractère caméléonesque du parti. Plusieurs éléments du discours du parti sont analysés par une grille d’analyse à trois niveaux : le discours populiste, la défense de la nation et le potentiel de rupture. En même temps, dans la perspective de l’élargissement de 2007, les conclusions de l’article portent sur les stratégies échouées de démantèlement de l’ostracisme national et international.El nacional-populismo marca de manera visible el panorama político rumano, pero es sobre todo el Partido de la Gran Rumania, convertido recientemente en el Partido Popular de la Gran Rumania, el que ha conseguido asegurarse una constancia electoral. A pesar de sus resultados electorales, su potencial para formar coalición ha sido ignorado completamente por los partidos parlamentarios rumanos. Por otro lado, el cordón sanitario que le aísla desde 1996, asegura de manera indirecta la estabilidad de la democracia rumana. ¿Cómo se puede temer pues el nacional-populismo rumano? El artículo propone una interpretación socio-histórica que pone en evidencia el carácter camaleónico del partido. En el se analizan otros elementos del discurso del partido a través de tres niveles: el discurso populista, la defensa de la nación y el potencial de ruptura. Al mismo tiempo, dentro de la perspectiva de ampliaci

  17. Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells

    Directory of Open Access Journals (Sweden)

    Lin JF

    2016-04-01

    Full Text Available Ji-Fan Lin,1 Yi-Chia Lin,2,3 Shan-Che Yang,1 Te-Fu Tsai,2,3 Hung-En Chen,2 Kuang-Yu Chou,2,3 Thomas I-Sheng Hwang2–4 1Central Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; 2Division of Urology, Department of Surgery, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; 3Division of Urology, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan; 4Department of Urology, Taipei Medical University, Taipei, Taiwan Background: Mammalian target of rapamycin (mTOR, involved in PI3K/AKT/mTOR pathway, is known to play a central role in regulating the growth of cancer cells. The PI3K/AKT/mTOR pathway enhances tumor survival and proliferation through suppressing autophagy, which sustains energy homeostasis by collecting and recycling cellular components under stress conditions. Conversely, inhibitors of the mTOR pathway such as RAD001 induce autophagy, leading to promotion of tumor survival and limited antitumor efficacy. We thus hypothesized that the use of autophagy inhibitor in combination with mTOR inhibition improves the cytotoxicity of mTOR inhibitors in bladder cancer.Materials and methods: The cytotoxicity of RT4, 5637, HT1376, and T24 human bladder cancer cells treated with RAD001 alone or combined with autophagy inhibitors (3-methyladenine (3-MA, bafilomycin A1 (Baf A1, chloroquine, or hydroxychloroquine was assessed using the WST-8 cell viability kit. The autophagy status in cells was analyzed by the detection of microtubule-associated light chain 3 form II (LC3-II, using immunofluorescent staining and Western blot. Acidic vesicular organelle (AVO formation in treated cells was determined by acridine orange vital staining. Inhibition of mTOR pathway by RAD001 was monitored by using a homemade quantitative polymerase chain reaction gene array, while phospho-mTOR was detected using Western blot. Induced apoptosis was determined by measurement of caspase 3/7 activity and DNA fragmentation in cells after

  18. Lumbar facet injection for the treatment of chronic piriformis myofascial pain syndrome: 52 case studies

    Directory of Open Access Journals (Sweden)

    Huang JT

    2014-08-01

    Full Text Available Jen-Ting Huang,1 Han-Yu Chen,2 Chang-Zern Hong,2 Ming-Ta Lin,3 Li-Wei Chou,4,5 Hsin-Shui Chen,6,7 Chien-Tsung Tsai,8 Wen-Dien Chang9  1Department of Orthopedic Surgery, Taichung Veterans General Hospital, 2Department of Physical Therapy, Hung-Kuang University, Sha Lu, 3Kuan-Ta Rehabilitation and Pain Clinic, Taichung, Taiwan; 4Department of Physical Medicine and Rehabilitation, China Medical University Hospital, 5School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; 6Department of Rehabilitation Medicine, Bei-Gang Hospital, School of Medicine, China Medical University, Yun-Lin, Taiwan; 7School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; 8Department of Rehabilitation Medicine, Da-Chien Hospital, Miao-Li City, Taiwan; 9Department of Sports Medicine, China Medical University, Taichung, Taiwan Background and aims: The aim of this study was to demonstrate the effectiveness of lumbar facet joint injection for piriformis myofascial pain syndrome. Methods: Fifty-two patients with chronic myofascial pain in the piriformis muscle each received a lumbar facet injection into the ipsilateral L5–S1 facet joint region, using the multiple insertion technique. Subjective pain intensity, trunk extension range, and lumbar facet signs were measured before, immediately after, and 2 weeks after injection. Thirty-six patients received follow-up for 6 months. Results: Immediately after the injection, 27 patients (51.9% had complete pain subsidence, 19 patients (36.5% had pain reduction to a tolerable level, and only 6 patients (11.5% had no pain relief to a tolerable level. Mean pain intensity was reduced from 7.4±0.9 to 1.6±2.1 after injection (P<0.01. This effectiveness lasted for 2 weeks in 49 patients (94.2%, and lasted for approximately 6 months in 35 (97.2% of 36 patients. The mean range of motion increased from 13.4±6.8 degrees to 22.1±6.0 degrees immediately

  19. COPD in Taiwan: a National Epidemiology Survey

    Directory of Open Access Journals (Sweden)

    Cheng SL

    2015-11-01

    Full Text Available Shih-Lung Cheng,1,2 Ming-Cheng Chan,3 Chin-Chou Wang,4 Ching-Hsiung Lin,5 Hao-Chien Wang,6 Jeng-Yuan Hsu,3 Liang-Wen Hang,7,8 Chee-Jen Chang,9 Diahn-Warng Perng,10,* Chong-Jen Yu6,* On behalf of the Taiwan COPD Consortium 1Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, 2Department of Chemical Engineering and Materials Science, Yuan Ze University, Chung-Li City, Taoyuan County, 3Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 4Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 5Division of Chest Medicine, Changhua Christian Hospital, Changhua City, Changhua County, 6Department of Internal Medicine, National Taiwan University Hospital, Taipei, 7Department of Pulmonary and Critical Care Medicine, Sleep Medicine Center, China Medical University Hospital, 8Department of Respiratory Therapy, College of Health Care, China Medical University, Taichung, 9Biostatistical Center for Clinical Research, Chang Gung Memorial Hospital, Linkou Branch, Guishan Township, Taoyuan County, 10Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Objectives: To determine the prevalence of COPD in Taiwan and to document the disease characteristics and associated risk factors.Methods: We conducted a random cross-sectional national survey of adults older than 40 years in Taiwan. Respiratory health screening questions identified subjects with diagnosed COPD or whose reported symptoms also fulfilled an epidemiological case definition; these were eligible to complete the survey, which also included indices of symptom severity and disability and questions on comorbidities, medical treatments, smoking habits, and occupations potentially harmful to respiratory health. Subjects with diagnosed COPD were subdivided by smoking status. Subjects who fulfilled the case definition

  20. Effects of a selective educational system on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan

    Directory of Open Access Journals (Sweden)

    Chen TY

    2015-03-01

    Full Text Available Tien-Yu Chen,1,2 Yu-Ching Chou,3 Nian-Sheng Tzeng,1,2,4 Hsin-An Chang,1,2,4 Shin-Chang Kuo,1,2,5 Pei-Yin Pan,1,2 Yi-Wei Yeh,1,2,5 Chin-Bin Yeh,1,2 Wei-Chung Mao1,2,6 1Department of Psychiatry, Tri-Service General Hospital, 2School of Medicine, National Defense Medical Center, 3School of Public Health, National Defense Medical Center, 4Student Counseling Center, National Defense Medical Center, 5Graduate Institute of Medical Sciences, National Defense Medical Center, 6Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Republic of China Objective: The aim of the study reported here was to clarify the effects of academic pressure on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan. Methods: This cross-sectional study enrolled 757 senior high school adolescents who were classified into four groups: Grade 1 (n=261, Grade 2 (n=228, Grade 3T (n=199; Grade 3 students who had another college entrance test to take, and Grade 3S (n=69; Grade 3 students who had succeeded in their college application. Fatigue, sleep quality, daytime sleepiness, and depression were assessed using the Chinese version of the Multidimensional Fatigue Symptom Inventory – Short Form, Pittsburgh Sleep Quality Index-Taiwan Form, the Chinese version of the Epworth Sleepiness Scale, and the Chinese version of the Beck Depression Inventory®-II (BDI-II, respectively. Results: Physical, emotional, and mental fatigue scores were all higher in higher-grade groups. The Grade 3T (test students had the worst fatigue severity, and the Grade 3S (success students had the least fatigue severity. More than half of the students (60.9% went to bed after 12 am, and they had on average 6.0 hours of sleep per night. More than 30% of the students in Grade 2 (37.3% and Grades 3T/S (30.2%/30.4% possibly had daily sleepiness problems. The students in Grade 3T had the worst BDI-II score (13.27±9.24, and the Grade 3S

  1. Reliability and validity of a dual-task test for skill proficiency in roundhouse kicks in elite taekwondo athletes

    Directory of Open Access Journals (Sweden)

    Chen CY

    2015-06-01

    Full Text Available Chung-Yu Chen,1 Jing Dai,2 I-Fan Chen,3 Kuei-Ming Chou,4 Chen-Kang Chang,5 1Department of Physical Education, 2Department of Sport Performance, National Taiwan University of Sport, Taichung, Taiwan; 3Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan; 4Department of Combat Sport, 5Sport Science Research Center, National Taiwan University of Sport, Taichung, Taiwan Abstract: The dual-task methodology, conducting two tasks simultaneously, may provide better validity than the traditional single-task tests in the environment that is closely related to real sport competitions. The purpose of this study is to determine the reliability and validity of a dual-task test that aims to measure the reaction time and skill proficiency in roundhouse kicks in elite and sub-elite taekwondo athletes. The dual-task results were compared to those in the single-task movements with various levels of complexity. The single-task movements A, B, and C were composed of one, three, and five roundhouse kicks, respectively. The dual-task movement D was composed of movement C and a push of a button in response to a light stimulus as the secondary task. The subjects were 12 elite and 12 sub-elite male taekwondo athletes. The test included four movements with five repeats of each movement in a randomized order. Each subject conducted the same test on two consecutive days. The intraclass correlation coefficient (ICC showed moderate-to-high correlation in the premotor time (ICC =0.439–0.634 in elite and ICC =0.681–0.824 in sub-elite, motor time (ICC =0.861–0.956 in elite and ICC =0.721–0.931 in sub-elite, and reaction time (ICC =0.692 in elite and ICC =0.676 in sub-elite in the secondary task in both groups. The elite athletes had significantly faster premotor time than their sub-elite counterparts in all the four movements (all P<0.05. The largest difference lies in the reaction time in the secondary task, in which the elite group

  2. PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells

    Directory of Open Access Journals (Sweden)

    Su WP

    2012-08-01

    Full Text Available Wen-Pin Su,1,2 Fong-Yu Cheng,3 Dar-Bin Shieh,3–6 Chen-Sheng Yeh,5–7 Wu-Chou Su1,2,81Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University; 2Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University; 3Institute of Oral Medicine, College of Medicine, National Cheng Kung University; 4Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University; 5Advanced Optoelectronic Technology Center; 6Center for Frontier Materials and Micro/Nano Science and Technology, and 7Department of Chemistry, National Cheng Kung University; 8Cancer Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Abstract: Background: Effective cancer chemotherapy remains an important issue in cancer treatment, and signal transducer and activator of transcription-3 (Stat3 activation leads to cellular resistance of anticancer agents. Polymers are ideal vectors to carry both chemotherapeutics and small interfering ribonucleic acid (siRNA to enhance antitumor efficacy. In this paper, poly(lactic-co-glycolic acid (PLGA nanoparticles loaded with paclitaxel and Stat3 siRNA were successfully synthesized, and their applications in cancer cells were investigated.Methods: Firstly, paclitaxel was enclosed by PLGA nanoparticles through solvent evaporation. They were then coated with cationic polyethylenimine polymer (PLGA-PEI-TAX, enabling it to carry Stat3 siRNA on its surface through electrostatic interactions (PLGA-PEI-TAX-S3SI. The size, zeta potential, deliver efficacy, and release profile of the PLGA nanocomplexes were characterized in vitro. The cellular uptake, intracellular nanoparticle trajectory, and subsequent cellular events were evaluated after treatment with various PLGA nanocomplexes in human lung cancer A549 cells and A549-derived paclitaxel

  3. On the formation and structure of rare-earth element complexes in aqueous solutions under hydrothermal conditions with new data on gadolinium aqua and chloro complexes

    Science.gov (United States)

    Mayanovic, Robert A.; Anderson, Alan J.; Bassett, William A.; Chou, I.-Ming

    2007-01-01

    Synchrotron X-ray spectroscopy experiments were made on the Gd(III) aqua and chloro complexes in low pH aqueous solutions at temperatures ranging from 25 to 500????C and at pressures up to 480??MPa using a hydrothermal diamond anvil cell. Analysis of fluorescence Gd L3-edge X-ray absorption fine structure (XAFS) spectra measured from a 0.006m Gd/0.16m HNO3 aqueous solution at temperatures up to 500????C and at pressures up to 260??MPa shows that the Gd-O distance of the Gd3+ aqua ion decreases steadily at a rate of ??? 0.007??A??/100????C whereas the number of coordinated H2O molecules decreases from 9.0 ?? 0.5 to 7.0 ?? 0.4. The loss of water molecules in the Gd3+ aqua ion inner hydration shell over this temperature range (a 22% reduction) is smaller than exhibited by the Yb3+ aqua ion (42% reduction) indicating that the former is significantly more stable than the later. We conjecture that the anomalous enrichment of Gd reported from measurement of REE concentrations in ocean waters may be attributed to the enhanced stability of the Gd3+ aqua ion relative to other REEs. Gd L3-edge XAFS measurements of 0.006m and 0.1m GdCl3 aqueous solutions at temperatures up to 500????C and pressures up to 480??MPa reveal that the onset of significant Gd3+-Cl- association occurs around 300????C. Partially-hydrated stepwise inner-sphere complexes most likely of the type Gd(H2O)??-nCln+3-n occur in the chloride solutions at higher temperatures, where ?? ??? 8 at 300????C decreasing slightly to an intermediate value between 7 and 8 upon approaching 500????C. This is the first direct evidence for the occurrence of partially-hydrated REE Gd (this study) and Yb [Mayanovic, R.A., Jayanetti, S., Anderson, A.J., Bassett, W.A., Chou, I-M., 2002a. The structure of Yb3+ aquo ion and chloro complexes in aqueous solutions at up to 500 ??C and 270 MPa. J. Phys. Chem. A 106, 6591-6599.] chloro complexes in hydrothermal solutions. The number of chlorides (n) of the partially-hydrated Gd

  4. Nanostructured Columns from Self-assembly of Complementary Molecular Components

    Institute of Scientific and Technical Information of China (English)

    YANG; Wen-sheng

    2001-01-01

    . Chem. , 96, 3 170(1992)[25]Mathias, J. P. , Simanek, E. E. , Zerkowski, J. A. , et al. , J. Am. Chem. Soc. , 116, 4 316(1994)[26]Ringsdorf, H. , Schlarb, B. , and Venzmer, J. , Angew. Chem. Int. Ed. Engl. , 27. 113(1988)[27]Hsu, C. S., Lin, J. H., Chou, L. R. et al., Macromolecules, 25, 7 126(1992)[28]Seto, C. T. , Mathias, J. P. , and Whitesides, G. M. , J. Am. Chem. Soc. , 115, 1 321(1993)[29]Hunter, C. A., Chem. Soc. Rev., 101(1994)[30]Beeson, J. C., Fitzgerald, L. J. , Gullucci, J. C., et al., J. Am. Chem. Soc. , 116, 4 621(1994)

  5. 网络成瘾者的行为冲动性——来自爱荷华赌博任务的证据%Internet Addicts' Behavior Impulsivity: Evidence from the Iowa Gambling Task

    Institute of Scientific and Technical Information of China (English)

    徐四华

    2012-01-01

    Internet addiction, defined as a maladaptive use of the Internet, is estimated to occur in 8-13% of college students (Chou, Condron, & Belland, 2005). It has become a serious mental health issue worldwide because addicts are impaired in various behavioral aspects including social interactions and academic performance (Morahan-Martin & Schumacher, 2000; Scherer, 1997; Young, 1998). Some researchers consider Internet addiction as a kind of behavioral addiction. However, there are few experimental studies on the cognitive functions of Internet addicts and limited data are available to compare Internet addicts with other addictive behaviors, such as drug abuse and pathological gambling. In the present study, we examined internet addicts' function of decision making. Two groups of participants, 42 Internet addicts (18~22 years old, 32 male, M = 19.79, SD = 1.14) and 42 controls (18~22 years old, 26 male, M = 19.71, SD = 1.13), were compared on the cognitive function and impulsivity by using a Chinese computerized versions of the IGT and Sensation Seeking Scale (SSS). In the IGT, subjects had to choose between four decks of cards. Unknown to the subjects, two piles offered larger short-term gains that are offset by greater risks of heavy losses, and hence were disadvantageous in the long run. The other two piles offered smaller short-term gains and a lower risk of loss that result in long-term maximization of the monetary payoff. The results of the present study showed that (1) compared with controls, sensation seeking of internet addicts was higher significantly, and internet addicts showed significantly higher scores on subscales of thrill and adventure seeking, disinhibition and boredom susceptibility, and they selected significantly less net decks in the Iowa Gambling Task. Furthermore, Internet addicts made no progress in selecting strategy along with the time course of the decision making. (2) reaction patterns for pure win-cards were consistent between

  6. Combined observations of a Bora event in the Adriatic Sea by means of ETA model and SAR data

    Science.gov (United States)

    Adamo, Maria; De Carolis, Giacomo; Morelli, Sandra; Rana, Fabio

    2013-04-01

    December 1992, Tellus, 48A, 357-367,1996. Lazić, L., Tošić, I.: A real data simulation of the Adriatic bora and the impact of mountain height on bora trajectories, Meteorol. Atmos. Phys., 66, 143-155, 1998. Mesinger F., Chou S.C., Gomes J.L., Jovic D., Bastos P., Bustamante J.F., Lazic L., Lyra A.A., Morelli S., Ristic I., Veljovic K.: An upgraded version of the Eta model, Meteorol Atmos Phys, 116, 63-79, 2012, DOI 10.1007/s00703-012-0182-z. Morelli, S., Berni, N.: On a bora event simulated by the Eta model, Meteorol. Atmos. Phys., 000, 1-12, 2002. Zecchetto S., De Biasio F.: Wavelet analysis applied to SAR images to detect atmospheric structures, Il Nuovo Cimento, 24, 81-88, 2001. Zecchetto S., De Biasio F.: A Wavelet Based Technique for Sea Wind Extraction from SAR Images, IEEE Trans. of Geoscience and Remote Sensing, 46, 10, 2983-2989, 2008.

  7. 奥朗德的困境--试析当前的法国政治生活

    Institute of Scientific and Technical Information of China (English)

    陈新丽; 冯传禄

    2013-01-01

    从奥朗德和执政党面临的局势看,法国似乎正陷入“不改革不行、改革即引发危机、而危机又反过来制擎改革”的泥潭。法国巴黎政治学院政治研究中心命名为“2013法国,全新的断裂”的调查研究数据显示:法国“民众对于政治生活的愤怒达到极致”。当前奥朗德的信任度现已下跌至30%,成为自1981年以来法国“最不受欢迎”的总统。经济困顿、社会问题重重、政治激荡,多重危机交互激励,令法国政治运行于高风险之下。法国的启示在于说明了国内经济停滞的危害性和经济发展重要性,改革势在必行,但改革需注意力度和处理好同民众的关系,而内政上的压力是无法通过外交行动来实现解除的。%A travers la situation à laquelle Hollande et son parti font face, la France semble être prise dans un bourbier où la France est dans l’obligation de se réformer, mais la réforme déclenche inévitablement la crise, qui peut à son tour restreindre la réforme. D’après l’enquête intitulée «France 2013: les nouvelles fractures» publiée sur le site du CEVIPOF, l’irritation vis-à-vis de la vie politique atteint des sommets. Hollande a échoué à redonner la confiance à la France, la confiance envers lui a chuté à trente pour cent, il est devenu, pour les Français depuis 1981, «le président le plus impopulaire ». Avec les difficultés économiques, les problèmes sociaux, l'agitation politique et l'interaction de multiples crises, la politique française est en situation de risque élevé. Tout cela révèle un fait, c’est que le développement est le premier mot et que la réforme est un impératif, mais la réforme doit prêter plus d’attention à de bonnes relations avec les habitants, et la pression sur les affaires intérieures ne peut pas être soulagée par une action diplomatique.

  8. Music therapy-induced changes in salivary cortisol level are predictive of cardiovascular mortality in patients under maintenance hemodialysis

    Directory of Open Access Journals (Sweden)

    Hou YC

    2017-02-01

    Full Text Available Yi-Chou Hou,1 Yen-Ju Lin,2 Kuo-Cheng Lu,1 Han-Sun Chiang,3 Chia-Chi Chang,4 Li-King Yang1 1Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 2Department of Nursing, Taipei Medical University, 3Graduate Institute of Basic Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, 4School of Gerontology Health Management, College of Nursing, Taipei Medical University, Taipei, Taiwan, Republic of China Background: Music therapy has been applied in hemodialysis (HD patients for relieving mental stress. Whether the stress-relieving effect by music therapy is predictive of clinical outcome in HD patients is still unclear.Methods: We recruited a convenience sample of 99 patients on maintenance HD and randomly assigned them to the experimental (n=49 or control (n=50 group. The experimental group received relaxing music therapy for 1 week, whereas the control group received no music therapy. In the experimental group, we compared cardiovascular mortality in the patients with and without cortisol changes.Results: The salivary cortisol level was lowered after 1 week of music therapy in the experimental group (−2.41±3.08 vs 1.66±2.11 pg/mL, P<0.05, as well as the frequency of the adverse reaction score (−3.35±5.76 vs −0.81±4.59, P<0.05, the severity of adverse reactions score (−1.93±2.73 vs 0.33±2.71, P<0.05, and hemodialysis stressor scale (HSS score (−6.00±4.68 vs −0.877±7.08, P<0.05. The difference in salivary cortisol correlated positively with HD stress score scales (r=0.231, P<0.05, systolic blood pressure (r=0.264, P<0.05, and respiratory rates (r=0.369, P<0.05 and negatively with finger temperature (r=−0.235, P<0.05 in the total study population. The 5-year cardiovascular survival in the experimental group was higher in patients whose salivary cortisol lowered by <0.6 pg/mL than that in patients whose salivary cortisol lowered by >0.6 pg/mL (83.8% vs

  9. Repeated vertebral augmentation for new vertebral compression fractures of postvertebral augmentation patients: a nationwide cohort study

    Directory of Open Access Journals (Sweden)

    Liang CL

    2015-03-01

    Full Text Available Cheng-Loong Liang,1 Hao-Kwan Wang,1 Fei-Kai Syu,2 Kuo-Wei Wang,1 Kang Lu,1 Po-Chou Liliang1 1Department of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan; 2Department of Pharmacy, China Medical University Hospital, Taichung City, Taiwan Purpose: Postvertebral augmentation vertebral compression fractures are common; repeated vertebral augmentation is usually performed for prompt pain relief. This study aimed to evaluate the incidence and risk factors of repeat vertebral augmentation.Methods: We performed a retrospective, nationwide, population-based longitudinal observation study, using the National Health Insurance Research Database (NHIRD of Taiwan. All patients who received vertebral augmentation for vertebral compression fractures were evaluated. The collected data included patient characteristics (demographics, comorbidities, and medication exposure and repeat vertebral augmentation. Kaplan–Meier and stratified Cox proportional hazard regressions were performed for analyses.Results: The overall incidence of repeat vertebral augmentation was 11.3% during the follow-up until 2010. Patients with the following characteristics were at greater risk for repeat vertebral augmentation: female sex (AOR=1.24; 95% confidence interval [CI]: 1.10–2.36, advanced age (AOR=1.60; 95% CI: 1.32–2.08, diabetes mellitus (AOR=4.31; 95% CI: 4.05–5.88, cerebrovascular disease (AOR=4.09; 95% CI: 3.44–5.76, dementia (AOR=1.97; 95% CI: 1.69–2.33, blindness or low vision (AOR=3.72; 95% CI: 2.32–3.95, hypertension (AOR=2.58; 95% CI: 2.35–3.47, and hyperlipidemia (AOR=2.09; 95% CI: 1.67–2.22. Patients taking calcium/ vitamin D (AOR=2.98; 95% CI: 1.83–3.93, bisphosphonates (AOR=2.11; 95% CI: 1.26–2.61, or calcitonin (AOR=4.59; 95% CI: 3.40–5.77 were less likely to undergo repeat vertebral augmentation; however, those taking steroids (AOR=7.28; 95% CI: 6.32–8.08, acetaminophen (AOR=3.54; 95% CI: 2.75–4.83, or nonsteroidal

  10. Physiologically based pharmacokinetic modeling of zinc oxide nanoparticles and zinc nitrate in mice

    Directory of Open Access Journals (Sweden)

    Chen WY

    2015-10-01

    Full Text Available Wei-Yu Chen,1 Yi-Hsien Cheng,2 Nan-Hung Hsieh,3 Bo-Chun Wu,2 Wei-Chun Chou,4 Chia-Chi Ho,4 Jen-Kun Chen,5 Chung-Min Liao,2,* Pinpin Lin4,* 1Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, 2Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, 3Institute of Labor, Occupational Safety and Health, Ministry of Labor, New Taipei City, 4National Institute of Environmental Health Sciences, 5Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Taiwan *These authors contributed equally to this work Abstract: Zinc oxide nanoparticles (ZnO NPs have been widely used in consumer products, therapeutic agents, and drug delivery systems. However, the fate and behavior of ZnO NPs in living organisms are not well described. The purpose of this study was to develop a physiologically based pharmacokinetic model to describe the dynamic interactions of 65ZnO NPs in mice. We estimated key physicochemical parameters of partition coefficients and excretion or elimination rates, based on our previously published data quantifying the biodistributions of 10 nm and 71 nm 65ZnO NPs and zinc nitrate (65Zn(NO32 in various mice tissues. The time-dependent partition coefficients and excretion or elimination rates were used to construct our physiologically based pharmacokinetic model. In general, tissue partition coefficients of 65ZnO NPs were greater than those of 65Zn(NO32, particularly the lung partition coefficient of 10 nm 65ZnO NPs. Sensitivity analysis revealed that 71 nm 65ZnO NPs and 65Zn(NO32 were sensitive to excretion and elimination rates in the liver and gastrointestinal tract. Although the partition coefficient of the brain was relative low, it increased time-dependently for 65ZnO NPs and 65Zn(NO32. The simulation of 65Zn(NO32 was well fitted with the experimental data. However, replacing partition coefficients of 65ZnO NPs with

  11. Ambient in-situ immersion freezing measurements - findings from the ZAMBIS 2014 field campaign for three ice nucleation techniques

    Science.gov (United States)

    Kohn, Monika; Atkinson, James D.; Lohmann, Ulrike; Kanji, Zamin A.

    2015-04-01

    well as a droplet freezing method on aerosol particles either collected in a suspension or on PM10-filters to obtain atmospheric IN concentrations based on the measured ambient aerosol. Investigation of physical properties (number and size distribution) and chemical composition as well as the meteorological conditions provide supplementary information that help to understand the nature of particles and air masses that contribute to immersion freezing. Acknowledgements We thank Hannes Wydler and Hansjörg Frei from ETH Zurich for their technical support. Furthermore, the authors want thank Franz Conen from the University of Basel for sharing equipment and training in the drop freezing experiment. References [1] Chou et al. (2011), Atmos. Chem. Phys., 11, 4725-4738. [2] Nicolet et al. (2010), Atmos. Chem. Phys., 10, 313-325. [3] Conen et al. (2012), Atmos. Meas. Tech., 5, 321-327. [4] Stopelli et al. (2014), Atmos. Meas. Tech., 7, 129-134.

  12. Motivation and Technology Use During Second-Language Study Abroad in the Digital Age

    Directory of Open Access Journals (Sweden)

    Aroline E. Seibert Hanson

    2016-12-01

    des participants (Gardner, 1985 ; Ushida, 2003 et leur maîtrise linguistique (Seibert Hanson et Carlson, 2014, et avons analysé qualitativement leurs réponses aux questions ouvertes posées au sujet de leurs objectifs et du choc culturel. Nous avons trouvé que des niveaux de motivation plus élevés étaient en corrélation avec de meilleures acquisitions linguistiques et avec moins d’usage de la technologie dans la langue maternelle (spécifiquement la technologie liée à l’Internet. Des niveaux de motivation plus bas étaient en corrélation avec un usage plus élevé de la technologie dans la langue maternelle, aussi bien que la perception d’avoir échoué à atteindre les objectifs de leur étude à l’étranger et de bien s’intégrer à la culture d’accueil.

  13. Clinical effectiveness, toxicity, and failure patterns of helical tomotherapy for postoperative oral cavity cancer patients

    Directory of Open Access Journals (Sweden)

    Hsieh CH

    2014-03-01

    Full Text Available Chen-Hsi Hsieh,1–3 Pei-Wei Shueng,1,4 Li-Ying Wang,5 Li-Jen Liao,6 Yu-Chin Lin,7 Ying-Shiung Kuo,8 Wu-Chia Lo,6 Chien-Fu Tseng,8 Hui-Ju Tien,1 Hsiu-Ling Chou,9,10 Yen-Ping Hsieh,11 Le-Jung Wu,1 Yu-Jen Chen3,12–14 1Department of Radiation Oncology, Far Eastern Memorial Hospital, 2Department of Medicine, 3Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, 4Department of Radiation Oncology, National Defense Medical Center, 5School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, 6Department of Otolaryngology, 7Division of Medical Oncology and Hematology, Department of Internal Medicine, 8Department of Dentistry and Oral Surgery, 9Department of Nursing, Far Eastern Memorial Hospital, 10Department of Nursing, Oriental Institute of Technology, Taipei, 11Department of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung, 12Department of Radiation Oncology, 13Department of Medical Research, Mackay Memorial Hospital, 14Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan Background: The outcome of postoperative high- and intermediate-risk oral cavity cancer (OCC patients receiving helical tomotherapy (HT remains limited. Materials and methods: Between November 2006 and November 2012, 53 postoperative high- and intermediate-risk OCC patients treated with HT were enrolled. Results: The 4-year locoregional, local, and regional control rates were 66%, 76.4%, and 94.3%, respectively. The 4-year locoregional control rates of oral tongue and buccal mucosa cancer were 88.3% and 37.1%, respectively (P=0.012. Eleven (20.8% patients experienced locoregional failure. In-field failure occurred in six of 53 (11.3% in the primary area and three of 53 (5.7% in the regional lymph-node area. No marginal failure was noted. Two of 53 (3.8% experienced out-of-field failure. The rates of grade 3 dermatitis

  14. Hypercitizenship and the Management of Genetic Diversity/Hyper-citoyenneté et gestion de la diversité génétique. La sociologie du droit et la bifurcation systemique principale entre la singularité du RING et l'âge néoféodale

    Directory of Open Access Journals (Sweden)

    Pitasi Andrea

    2011-12-01

    Full Text Available Cet essai se focalise sur la fonction allocative des systèmes judiciaires exercée pour attirer/rejeter des capitauxdifférents sur la base de leur propres procédures de création de règles juridiques et de lois. Cette fonction estaujourd’hui d’une importance fondamentale. En effet, le genre humain est avant tout une bifurcation évolutionniste etsystémique entre le concept heideggérien de Gegnet d’une convergence stratégique et extrêmement rapide (parexemple, la Singularité parmi la robotique, l’informatique, les nanotechnologies et la génétique (RINGs – qui est entrain de redessiner la vie humaine par rapport à ses styles et ses standards qualitatifs de vie et tout particulièrement auxdomaines de la santé et de l’environnement - et ce qu’on appelle le Scenario Néo-féodal (NS proposé par ceux quipensent que le Modèle Industriel a échoué et que le seul moyen de sauver le genre humain et son environnement seraitune espèce de voyage en arrière dans le temps pour proposer de nouveau le style de vie du Moyen-âge caractérisé par lalenteur et l’austérité. Cet essai examine la littérature internationale la plus récente et la plus influente concernante lesdeux alternatives de bifurcation et avance une modification potentielle de paradigme dans l’approche systémique afin dereformuler la carte conceptuelle du changement global à travers une épistémologie systémique de la sociologie du droit.AbstractThis essay is essentially theoretical and is focused on the allocative function of the legal systems to attract/rejectdifferent capitals according to their procedures to shape norms and laws. This function of the legal systems is pivotal inour times as humankind is before a systemic and evolutionary bifurcation between the heideggerian Gegnet of astrategic, high speed convergence (i.e. Singularity among robotics, informatics, nanotechonologies and genetics(RINGs - which is going to reshape the human life

  15. 奥利亚罗非鱼DMO和DMT蛋白二级结构和B细胞抗原表位的预测%Prediction of the Secondary Structure and B Cell Epitopes of DMO and DMT Protein in Oreochromis aureus

    Institute of Scientific and Technical Information of China (English)

    曹谨玲; 陈剑杰; 俞菊华; 吴婷婷

    2006-01-01

    以DMO和DMT氨基酸序列为基础,采用Garnier-Robson法、Chou-Fasman法和KarplusSchulz法预测蛋白质的二级结构;按Kyte-Doolittle法、Emini法和Jameson-Wolf法预测DMO和DMT蛋白的B细胞抗原表位.预测结果表明:在DMO蛋白N-端第80~112,144~147,193~194,251~255,260~269区段和279~283区段,DMT蛋白N-端61~86,98~105,140~146,239~241区段和第269~273区段,可能是α-螺旋中心;DMO蛋白N-端第59~61,69~70,148~150区段和383~390区段,DMT蛋白的N-端第125~129,207~213,255~264区段和第281~284区段,可能是β-折叠中心;在DMO蛋白分子N-端40~41,44~45,50~51,128~129,189~192,204~207,216~222,226~233,244~246,298~299区段和第323~326区段和DMT蛋白分子N-端第12~13,26~27,43~44,58~60,93~95,115~120,136~139区段和第149~151区段具有较柔软的结构,这些区段有可能进行一定幅度的摆动或折叠而形成较复杂的三级结构.DMO蛋白N-端第1~5,41~51,65~67,86~89,98~110,154~170,183~203,205~248,258~264,284~291,293~298,270~375,389~392,402~410区域和DMT蛋白N-端第1~9,17~28,77~84,114~123,131~139,157~184,196~207区域可能是B细胞表位优势区域.以蛋白质的二级结构预测作为辅助手段,用抗原指数,亲水性参数和可及性参数预测DMO和DMT蛋白的B细胞表位,为DMO和DMT蛋白单克隆抗体的制备提供了线索,为系统研究奥利亚罗非鱼DMO和DMT基因的性别调控机理提供参考.

  16. Circulating angiogenic factors in a pregnant woman on intensive hemodialysis: a case report.

    Science.gov (United States)

    Akbari, Ayub; Hladunewich, Michelle; Burns, Kevin; Moretti, Felipe; Arkoub, Rima Abou; Brown, Pierre; Hiremath, Swapnil

    2016-01-01

    Bien que peu probable, une grossesse chez les patientes sous dialyse chronique survient en de rares occasions. Dans ces cas très précis, l’hémodialyse intensive est considérée comme le traitement offrant les meilleures chances de survie pour l’enfant à naitre. Chez les patientes enceintes souffrant d’insuffisance rénale chronique, mais non dialysée, les facteurs antiangiogéniques circulants améliorent le pronostic de la grossesse. Les données sont toutefois limitées en ce qui concerne le cas de patientes enceintes sous dialyse. Nous discutons du cas d’une patiente avec un historique de néphrite interstitielle et dont la transplantation rénale a échoué après 8 ans en raison d’une glomérulite extra-membraneuse. Elle avait à ce moment entrepris une dialyse à raison de trois séances par semaine. La patiente est tombée enceinte six semaines après le début du traitement par dialyse et a dès lors été transférée au traitement par l’hémodialyse intensive. Le bébé, une fille de 2 012 kg en parfaite santé, est né par césarienne à 35 semaines de gestation, car la mère souffrait d’hypertension. Deux facteurs antiangiogéniques ; le facteur de croissance placentaire PIGF ainsi que la tyrosine kinase sFlt-1, ont été dosés à 32, 33 et 34 semaines de gestation de même qu’une, deux et trois semaines postpartum. Les taux mesurés se situaient à des niveaux attendus chez les patients souffrant d’insuffisance rénale chronique et n’indiquaient pas de prééclampsie. L’étude de ce cas particulier vient enrichir la documentation existante en regard de l’utilisation de l’hémodialyse intensive chez les patientes enceintes. Ce cas précis laisse croire qu’il est sécuritaire pour l’enfant à naitre d’amorcer une telle procédure dès les premières semaines de la grossesse chez une femme souffrant d’insuffisance rénale chronique. Ce cas montre également que dans ces conditions, les concentrations s

  17. Accessibility analysis in manufacturing processes using visibility cones

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    [1]Lozana-Prez,T.,Spatial planning: A configuration space approach,IEEE Transactions on Computers,1983,C-32(2): 108-120.[2]Chen,L L,Woo,T C.,Separating and intersecting spherical polygons: Computing machinability on three-,four-,and five-axis numerically controlled machines,ACM Transaction on Graphics,1993,12(4): 305-326.[3]Kweon,S.,Medeiros,D.J.,Part orientations for CMM inspection using dimensioned visibility maps,Computer-Aided Design,1998,30(9): 741-749.[4]Lim,C.P.,Menq,C.H.,CMM feature accessibility and path generation,International Journal of Production Research,1994,32(3): 597-618.[5]Chen,L.L.,Chou,S.Y.,Woo,T.C.,Parting directions for mould and die design,Computer-Aided Design,1993,25(12): 762-768.[6]Yin,Z.P.,Ding,H.,Xiong,Y.L.,Mouldability analysis for near-net-shape manufactured parts using freedom cones,International Journal of Advanced Manufacturing Technology,2000,16(3): 169-175.[7]Wilson,R.H.,On geometric assembly planning,Ph.D.Thesis,Stanford: Stanford University,1992.[8]Spyridl,A.J.,Automatic generation of high level inspection plans for coordinate measuring machines,PhD.Thesis,Los Angeles: University of Southern California,1994.[9]Woo,T.C.,Visibility maps and spherical algorithms,Computer Aided Design,1994,26(1): 6-16.[10]Xiong,Y.L.,Theory of point contacts restraint and qualitative analysis of robot grasping,Science in China,Series A,1994,37(5),629-640.[11]Ding,H.,Xiong,Y.L.,Computational manufacturing,In Intl.Conf.on Frontiers of Design and Manufacturing,2000.[12]Yin,Z.P.,Feature-based product modeling and accessibility analysis for virtual prototyping,Ph.D.Thesis,Wuhan: Huazhong University of Science and Technology,2000.[13]Zhang,H.S.,Effective Occlusion Culling for the Interactive Display of Arbitrary Models,Ph.D.Thesis,Asheville: University of North Carolina,1998.[14]Yin,Z.P.,Ding,H.,Xiong,Y.L.,Visibility theory and algorithms with application to manufacturing processes

  18. Factors associated with the prescription of inhaled corticosteroids in GOLD group A and B patients with COPD – subgroup analysis of the Taiwan obstructive lung disease cohort

    Directory of Open Access Journals (Sweden)

    Wei YF

    2015-09-01

    Full Text Available Yu-Feng Wei,1 Ping-Hung Kuo,2 Ying-Huang Tsai,3 Chi-Wei Tao,4 Shih-Lung Cheng,5,13 Chao-Hsien Lee,6 Yao-Kuang Wu,7 Ning-Hung Chen,8 Wu-Huei Hsu,9 Jeng-Yuan Hsu,10 Ming-Shian Lin,11 Chin-Chou Wang12 1Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; 2Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 3Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan; 4Department of Internal Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan; 5Division of Thoracic Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan; 6Division of Pulmonary and Critical Care Medicine, Mackay Memorial Hospital, Taipei, Taiwan; 7Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Taipei, Taiwan; 8Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan; 9Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University and China Medical University Hospital, Taichung, Taiwan; 10Division of Chest Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 11Division of Pulmonary and Critical Care Medicine, Chia-Yi Christian Hospital, Chiayi, Taiwan; 12Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 13Department of Chemical Engineering and Materials Science, Yuan-Ze University, Taoyuan, Taiwan Background and objective: The overprescription of inhaled corticosteroids (ICS in the current Global Initiative for Chronic Obstructive Lung Disease (GOLD group A and B patients with chronic obstructive pulmonary disease (COPD is not uncommon in clinical practice. The aim of this study was to explore the factors associated with the use of ICS in these patients. Methods: The Taiwan obstructive lung disease (TOLD study was a

  19. Specific detection of CD133-positive tumor cells with iron oxide nanoparticles labeling using noninvasive molecular magnetic resonance imaging

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    Chen YW

    2015-11-01

    Full Text Available Ya-Wen Chen,1,2 Gunn-Guang Liou,3 Huay-Ben Pan,4,5 Hui-Hwa Tseng,5,6 Yu-Ting Hung,4 Chen-Pin Chou4,5,7,8 1National Institute of Cancer Research, National Health Research Institutes, Miaoli, 2Graduate Institute of Basic Medical Science, China Medical University, Taichung, 3Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, 4Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, 5School of Medicine, National Yang-Ming University, Taipei, 6Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, 7Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, 8School of Medicine, National Defense Medical Center, Taipei, Taiwan Background: The use of ultrasmall superparamagnetic iron oxide (USPIO nanoparticles to visualize cells has been applied clinically, showing the potential for monitoring cells in vivo with magnetic resonance imaging (MRI. USPIO conjugated with anti-CD133 antibodies (USPIO-CD133 Ab that recognize the CD133 molecule, a cancer stem cell marker in a variety of cancers, was studied as a novel and potent agent for MRI contrast enhancement of tumor cells. Materials and methods: Anti-CD133 antibodies were used to conjugate with USPIO via interaction of streptavidin and biotin for in vivo labeling of CD133-positive cells in xenografted tumors and N-ethyl-N-nitrosourea (ENU-induced brain tumors. The specific binding of USPIO-CD133 Ab to CD133-positive tumor cells was subsequently detected by Prussian blue staining and MRI with T2-weighted, gradient echo and multiple echo recombined gradient echo images. In addition, the cellular toxicity of USPIO-CD133 Ab was determined by analyzing cell proliferation, apoptosis, and reactive oxygen species production. Results: USPIO-CD133 Ab specifically recognizes in vitro and labels CD133-positive cells, as validated using Prussian blue staining and MRI. The assays of cell proliferation, apoptosis, and

  20. Pemetrexed had significantly better clinical efficacy in patients with stage IV lung adenocarcinoma with susceptible EGFR mutations receiving platinum-based chemotherapy after developing resistance to the first-line gefitinib treatment

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    Yang CJ

    2016-03-01

    Full Text Available Chih-Jen Yang,1–4 Ming-Ju Tsai,2,4 Jen-Yu Hung,2,3 Ta-Chih Liu,3,5 Shah-Hwa Chou,3,6 Jui-Ying Lee,6 Jui-Sheng Hsu,3,7 Ying-Ming Tsai,1,2,4 Ming-Shyan Huang,2–4 Inn-Wen Chong2,3 1Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, 3Faculty of Medicine, College of Medicine, 4Graduate Institute of Medicine, College of Medicine, 5Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 6Division of Chest Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 7Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Background: Increased evidences show that epidermal growth factor receptor (EGFR-tyrosine kinase inhibitors such as gefitinib could prolong progression-free survival (PFS compared with cytotoxic chemotherapy for metastatic lung nonsquamous cell carcinoma harboring susceptible EGFR mutation, and gefitinib was served as the first-line therapy. However, acquired resistance is inevitable, but the salvage therapies are still unclear.Patients and methods: We designed a retrospective study of the salvage therapy and enrolled patients with stage IV lung adenocarcinoma who had mutated EGFR and developed an acquired resistance to the first-line gefitinib in two university-affiliated hospitals in Taiwan during June 2011 to December 2014. Age, sex, smoking history, EGFR gene mutation, performance statuses, response rate, PFS2 (the PFS in salvage therapy, and overall survival (OS2, the OS in salvage therapy were recorded.Results: Two hundred and nine patients with mutated EGFR and who took gefitinib as first-line therapy were identified in the period, and a total of 98 patients who had been treated with salvage therapy with cytotoxic chemotherapy or erlotinib were eligible for this

  1. La réinvention des routes incas : représentations et construction de la mémoire au Pérou (2001-2011 The Reinvention of the Inca Roads: Representations and Construction of Memory in Peru (2001-2011 La reinvención de las rutas incas: representaciones y construcción de la memoria en el Perú (2001-2011

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    Sébastien Jallade

    2012-05-01

    Full Text Available Le « Qhapaq Ñan » (chemin principal andin constitue un exemple éclairant d’institutionnalisation de la mémoire au Pérou, marqué par quatre facteurs : le rôle central dévolu aux scientifiques et aux organisations internationales favorise l’irruption de logiques de développement et de patrimonialisation ; l’État péruvien privilégie une représentation symbolique du territoire au profit d’un public de plus en plus globalisé; la « Marche pour la paix », une commémoration politique ancrée dans le contexte local, a été marquée par un succès populaire important, mais non relayé par les élites ; enfin les projets de tourisme soutenable fondés sur des objectifs de conservation et d’authenticité ont échoué à donner une réalité concrète à leurs propositions. Ces différentes stratégies n’ont jamais réussi à impliquer durablement les communautés riveraines, et ce malgré les objectifs affichés à l’origine. Elles témoignent des enjeux contradictoires de la représentation des Andes péruviennes dans le contexte d’un pays pluriculturel.The «Qhapaq Ñan» (main Andean road is a unprecedented example of institutionalization of memory in contemporary Peru, characterized by four aspects: the central role given to scientists and international organizations favors the emergence of patterns of development and heritage listing; the Peruvian State tends to stress a symbolic representation of territory for the benefit of a globalized audience; the «Peace march», a political initiative well grounded in the local context, was rewarded by significant popular success, but the elite did not follow it up; finally, sustainable tourism projects based on conservation and authenticity goals have failed to put their proposals in practice. The original objectives stressing participation of local communities were not achieved on a lasting basis. These findings underline conflicting issues of representation of the

  2. Sun Xi-miao in T he Biogr aphy of T he Avatamsaka - Sutra

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    LEE Hyun- Sook

    2005-12-01

    Full Text Available This paper aimed to introduce and examine the biography of Sun Xi-miao(孫思邈581-682 which I found in The Biography of The Avatamsaka-Sutra(華嚴經傳記, that Fazang(法藏643-712 wrote in 692 A.D. This document was neglected to understand Sun who was the famous medical writer of the collection of prescriptions, the Bei ji qian jin yao fang(備急千金要方. His life is rather well documented, because he has his own biographies in Jiu Tang shu and Xin Tang shu(新唐書 which cited from Da Tang sin yu(大唐新語, published in 807. But I found several new informations about Sun in The Biography of The Avatamsaka-Sutra, such as he use to be a military medicine in the troops of Li Yuan(李淵 who became the first emperor Kao Tsu(高祖 of Tang dynasty and treat Sun with great favour. This document let us know that the Bei ji qian jin yao fang(備急千金要方 was dedicated to Kao Tsu, known as published in 652 A.D. MY CONCLUSIONS ARE AS FOLLOWS: First, it was written by Fazang in 692 A.D, who was the real establisher of the fraternity of the Avatamsaka in China, for the purpose of encouraging to copy the Avatamsaka-Sutra(華嚴經. According to this biography, Sun made 750 copies to persuade the monks and the peoples, and that's the reason Fazang wrote his biography.Secondly, it was not conveyed to posterity, such as Sun was good looking, tall and use to be the medicine of Kao Tsu and dedicated his medical book to the first emperor. It might be left out for Tai Tsung(太宗's sake in the official records, who murdered his brother, the heir apparent to the throne and became the second emperor by himself. On the contrary, it was written in Da Tang sin yu, Jiu and Xin Tang shu that Sun made a prediction that his collection of prescriptions would help the holyman after 50 years from Xuan Di(宣帝578-579 of Northern Chou(北周 Dynasty. Holyman meant Tai Tsung. It shows that Sun's biographies in the Da Tang sin yu, Jiu and Xin Tang Shu were

  3. Poorer prognosis in Taiwanese female ever smokers with stage IV lung adenocarcinoma who were readministered a tyrosine kinase inhibitor

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    Yang CJ

    2016-03-01

    Full Text Available Chih-Jen Yang,1–4 Ming-Ju Tsai,2 Jen-Yu Hung,2,4 Ying-Ming Tsai,1–3 Jui-Ying Lee,5 Shah-Hwa Chou,5,6 Ta-Chih Liu,7,8 Mei-Chiou Shen,9 Ming-Shyan Huang,2,4,10 Inn-Wen Chong2,6 1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 4Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Division of Chest Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 6Department of Respiratory Care, College of Medicine, Kaohsiung Medical University, 7Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 8Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, 9Department of Pharmacy, Kaohsiung Medical University Hospital, 10Division of Geriatric Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Background: Readministering a second epidermal growth factor receptor (EGFR tyrosine kinase inhibitor (TKI in patients with lung adenocarcinoma with acquired resistance to an initial EGFR TKI is a common treatment strategy. However, the prognostic factors for the second EGFR TKI are still uncertain.  Patients and methods: In this retrospective study, we enrolled patients with stage IV lung adenocarcinoma diagnosed between June 2009 and October 2013 at two university-affiliated hospitals in Taiwan. Basic characteristics including age, sex, smoking status, performance status, EGFR mutation status, tumor response, and progression-free survival (PFS of the second

  4. Intelligence quotient discrepancy indicates levels of motor competence in preschool children at risk for developmental delays

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    Yu TY

    2016-02-01

    Full Text Available Tzu-Ying Yu,1 Kuan-Lin Chen,2,3 Willy Chou,4,5 Shu-Han Yang,4 Sheng-Chun Kung,4 Ya-Chen Lee,2 Li-Chen Tung4,6,7 1Department of Occupational Therapy, College of Medicine, I-Shou University, Kaohsiung, 2Department of Occupational Therapy, College of Medicine, National Cheng Kung University, Tainan, 3Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 4Department of Physical Medicine and Rehabilitation, Chi-Mei Medical Center, Tainan, 5Department of Recreation and Health Care Management, Cha Nan University of Pharmacy and Science, Tainan, 6School of Medicine, Kaohsiung Medical University, Kaohsiung, 7School of Medicine, Chung Shan Medical University, Taichung, Taiwan Purpose: This study aimed to establish 1 whether a group difference exists in the motor competence of preschool children at risk for developmental delays with intelligence quotient discrepancy (IQD; refers to difference between verbal intelligence quotient [VIQ] and performance intelligence quotient [PIQ] and 2 whether an association exists between IQD and motor competence.Methods: Children’s motor competence and IQD were determined with the motor subtests of the Comprehensive Developmental Inventory for Infants and Toddlers and Wechsler Preschool and Primary Scale of Intelligence™ – Fourth Edition. A total of 291 children were included in three groups: NON-IQD (n=213; IQD within 1 standard deviation [SD], VIQ>PIQ (n=39; VIQ>PIQ greater than 1 SD, and PIQ>VIQ (n=39; PIQ>VIQ greater than 1 SD.Results: The results of one-way analysis of variance indicated significant differences among the subgroups for the “Gross and fine motor” subdomains of the Comprehensive Developmental Inventory for Infants and Toddlers, especially on the subtests of “body-movement coordination” (F=3.87, P<0.05 and “visual-motor coordination” (F=6.90, P<0.05. Motor competence was significantly

  5. Identification of brassinosteroid responsive genes in Arabidopsis by cDNA array

    Institute of Scientific and Technical Information of China (English)

    HU; Yuxin; (

    2001-01-01

    cdc5+ homolog of a higher plant, Arabidopsis thaliana, Proc. Natl. Acad. Sci. USA, 1996, 93: 13371-13376.[15]Javerzat, J. P., Cranston, G., Allshire, R. C., Fission yeast genes which disrupt mitotic chromosome segregation when overexpressed, Nucl. Acids Res., 1996, 24: 4676-4683.[16]Dhaubhadel, S., Chaudhary, S., Dobinson, K. F. et al., Treatment with 24-epibrassinolide, a brassinosteroid, increases the basic thermotolerance of Brassica napus and tomato seedlings, Plant Mol. Biol., 1999, 40: 333-342.[17]Beato, M., Herrlich, P., Schytz, G., Steroid hormone receptors: many actors in search of a plot, Cell, 1995, 83: 153-156.[18]Chou, I. T., Gasser, C. S., Characterization of the cyclophilin gene family of Arabidopsis thaliana and physiologenetic analysis of known cyclophilin proteins, Plant Mol. Biol., 1997, 35: 873-892.[19]Sykes, K., Gething, M. J., Sambrook, J., Proline isomerases function during heat shock, Proc. Natl. Acad. Sci. USA, 1993, 90: 5853-5857.[20]Marivet, J., Frendo, P., Burkard, G., DNA sequence analysis of a cyclophilin gene from maize: developmental expression and regulation by salicylic acid, Mol. Gen. Genet., 1995, 247: 222-228.[21]Kagaya, Y., Ohmiya, K., Hattori, T., RAV1, a novel DNA-binding protein, binds to bipartite recognition sequence through two distinct DNA-binding domains uniquely found in higher plant, Nucleic Acids Res., 1999, 27: 470-478.[22]Neff, M. M., Nguyen, S. M., Malancharuvil, E. J. et al., BAS1: a gene regulating brassinosteroid levels and light responsiveness in Arabidopsis, Proc. Natl. Acad. Sci. USA, 1999, 96: 15316-15323.[23]Chory, J., Nagpal, P., Peto, C. A., Phenotypic and genetic analysis of det2, a new mutant that affects light-regulated seedling development in Arabidopsis, Plant Cell, 1991, 3: 445-459.[24]Papenbrock, J., Grafe, S., Kruse, E. et al., Mg2+-chelatase of tobacco: identification of a ChlD cDNA sequence encoding a third subunit, analysis of the interaction of the three

  6. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Brain & Development”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    -ACETYLCYSTEINE AMIDE (NACA REDUCES CELL DEATH AFTER EXPOSURE TO OXIDATIVE STRESS IN A PORCINE EPITHELIAL-LIKE EMBRYONIC EFN-R KIDNEY CELL LINE • T. Benterud, S. Manueldas, L. Pankratov, R. Solberg, A. Nordgren, O.D. Saugstad, L.O. BaumbuschABS 7. MELATONIN-INDUCED IMMUNE CELL RESPONSES IN INFANTS WITH NEONATAL ENCEPHALOPATHY PRE AND POST THERAPEUTIC HYPOTHERMIA TREATMENT • S. Aslam, V. McEneaney, R.W.G. Watson, A. O’Neill, E.J. MolloyABS 8. BLOOD PRESSURE DURING THE IMMEDIATE NEONATES TRANSITION: IS THE MIDDLE ARTERY PRESSURE (MAP RELEVANT FOR THE REGIONAL CEREBRAL OXYGENATION (crSO2? • N. Baik, B. Urlesberger, B. Schwaberger, G. Schmölzer, A. Avian, G. PichlerABS 9. BETWEEN 1993 AND 2012: EVOLUTION OF CEREBRAL PALSY IN PRETERM CHILDREN • M. Bickle Graz, J. Schneider, A.C. TruttmannABS 10. N-ACETYLCYSTEINE AMIDE (NACA MAY HAVE NEUROPROTECTIVE PROPERTIES AFTER PERINATAL ASPHYXIA • T. Benterud, L. Pankratov, R. Solberg, A. Nordgren, L.O. Baumbusch, O.D. SaugstadABS 11. BRAIN INTERSTITIAL PH CHANGES DURING THE SUBACUTE PHASE IN A NEWBORN PIGLET PERINATAL ASPHYXIA MODEL • J. Németh, G. Remzső, V. Tóth-Szűki, F. DomokiABS 12. NEUROPROTECTIVE EFFECT OF REMIFENTANIL ON EXCITOTOXIC-INDUCED BRAIN DAMAGE IN NEONATAL MICE • C. Chollat, F. Tourrel, M. Lecointre, Y. Ramdani, S. Marret, B. Gonzalez, S. JégouABS 13. THE SafeBoosC II TRIAL: REDUCING CEREBRAL HYPOXIA WITHOUT CHANGING EARLY BIOMARKERS OF BRAIN INJURY • A.M. Plomgaard, W. van Oeveren, T.H. Petersen, T. Alderliesten, T. Austin, F. van Bel, M. Benders, O. Claris, E. Dempsey, A. Franz, M. Fumagalli, C. Gluud, C. Hagmann, S. Hyttel-Soerensen, P. Lemmers, A. Pellicer, G. PicABS 14. PREDICTING WHITE MATTER DAMAGE BY EVALUATION OF THE LINEAR GROWTH RATE OF CORPUS CALLOSUM IN VERY LOW BIRTH WEIGHT INFANTS • H. Huang, C. Chen, H. Chou, P. Tsao, W. HsiehABS 15. REGIONAL AND DEVELOPMENTAL SCREENING OF BILIRUBIN TOXICITY: HIPPOCAMPUS IS THE MOST SENSIBLE REGION • M. Dal Ben, C. Tiribelli, S. GazzinABS 16. EFFICACY

  7. THE SEQUENCE OF PALEOENVIRONMENTAL CHANGES SINCE ABOUT 4KA B. P., RECORDED BY NIYA SECTION IN SOUTHERN MARGIN OF TARIM BASIN

    Institute of Scientific and Technical Information of China (English)

    ZHONG; Wei

    2001-01-01

    [1]CHEN Pan-qin. 1992. The Core Project of International Research of Global Changes (1) [M]. Beijing: Atmosphere Publishing House, 70. (in Chinese)[2]Committee of National Natural Science Foundation of China, 1995. Geography Science[M]. Beinjing: Science Press,105. (in Chinese)[3]HUMHREY J D, FERRING C R , 1994. Stable isotopic evidence for latest pleistocene and central Holocene climatic change in north Texas[J]. Quaternary Research, 41:200-213.[4]GUAN You-zhi, LI Zhi-zhong, 1994. The distribution of geochemical elementin and paleoclimate in the Holocene sediment, northern part of Taklimakan desert[J]. Arid Land Geography, 17(3): 19-26. (in Chinese)[5]LIJia-lin, 1988. Guide to Geochemstry[M]. Lanzhou: Lanzhou University Press, 88-92. (in Chinese)[6]LIU Yin-jun, 1984. Element Geochemistry[M]. Beijing: Science Press. (in Chinese)[7]OLDFIELD F, 1991. Environmental Magnetism-a personal prospective[J]. Quaternary Science Review, 10:73-85.[8]SUN Xiang-jun, DU Nai-qiu, WEN Chen-yu et al., 1994, Paleovegetation and paleoenvironment of Mamas Lake, Xinjiang,N. W. China, during the last 14000 years[J]. Quaternary Sciences, 3:239-247. (in Chinese)[9]WU Jin-lu, 1997. Composition of the stable authigenic isotope of carbonate of RM core and its paleoclimatic implication in Tibetan plateau[J]. Scientia Geographica Sinica, 17(1):18 - 22. (in Chinese)[10]YIN Ze-sheng, YANG Yi-chou, WANG Shou-chun, 1993.Holocence environmental changes and Human being' s civilization in arid northwestern China[A]. In: ZHANG Lan-sheng(ed. ). Research on Living Environmental Changes in China During Historic Period[C]. Beijing: Ocean Press,260-283. (in Chinese)[11]YAO Tan-dong, SHI Ya-feng, THOMPSON L G et al., 1992.Climatic changes of Holocene reflected in the ice core from Dunde[A]. In: SHI Ya-feng. The Climates and Environments of Holocenc Megathermal in China[C]. Beijing: China Ocean Press, 206-210. (in Chinese)[12]YAO Tan-dong, YANG Zhi-hong, JIAO

  8. ESTUDIO SOBRE LOS PROCESOS COLABORATIVOS DEL AULA EN ESCUELAS DEMOCRÁTICAS Y COLABORATIVAS: UN PLANTEAMIENTO PARA SU APLICACIÓN EN LA ENSEÑANZA DE LA GEOGRAFÍA

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    Juvenal Padrón Fragoso

    2005-12-01

    reflected in its internal processes that respond in the main to non current expositions that do not bear in mind the new realities - the globalization and the multiculturality - and its requirements. School is not far away fiom al1 this, on the contrary, its role across the curriculum in the reconstruction of a new cultural identity based on the principies of the cooperation and the incorporation is a challenge on which it is necessary to outline the bases of the new school. In this study we try to give to know the perception that the pro- fessorship has with regard to the cooperative dynamics in the centers as response to those new rea- lities and problems. KEY WORDS:School.Globalization, Socialization, Multiculturality, Curriculum, Incorporation, Collaborative professorship, Cooperative learning, Didactic methods, Scholastic culture, Democracy. RESUMÉ:L'école est soumise a de nouveaux problemes, conséquence d'un mode chaque fois plus glo- balisé. Celle-ci vit une grave crise dídentité qui implique des conséquences négatives dans ses objectifs et processus internes. Certaines expectatives sur le role de l'école ont échoué au cours du L'école n'est pas éloignée de tout cela, au contraire, son r6le, a travers de son plan d'étude, dans la reconstruction d'une nouvelle identité culturelle basée sur les principes de la coopération et de l'inclusion, est un défit sur lequel il faut profiler les bases de la nouvelle école. Dans cette étude, nous essayons de faire connaitre la perception du professorat en ce qui concerne les dynamiques coopératives dans les centres comme réponse a ces nouvelles réalités et problemes. MOTS CLE:École. Globalisé, Socialisation, Multiculture, Plan d'étude, Inclusion, Apprentissage coopératif, Professorat de collaboration, Méthodes didactiques, Culture scolaire, Démocratie. 

  9. The Accumulation, Specialization, and Characteristics of Management Theories%管理学说的积淀、分道及特色

    Institute of Scientific and Technical Information of China (English)

    张国有

    2012-01-01

    Management theories have gone through a process of long - term accumulation, divided into special- ized subfields, and developed the logic of its own. During the long period of accumulation, management theories grow, become specialized, compare, and gradually mature. According to current document, the earliest work in China regarding management is "Sunzi bingfa" ( Arts of War by Sunzi) written by Sun Wu 2500 years ago. This piece of work is a systematic comprehension of management as well as a logical presentation of management mecha- nism in military activities. The management theory from this work has profound influence and wide applications on activities in non - military fields. The essence of "Sunzi bingfa" is actually the way of management. In the 2500 - year development of management theories, "Sunzi bingfa" actually is a classical work, as it is the earliest written work, based on military affairs, and has produced a profound and far- reaching influence on management theories worldwide. After the masterpiece of "Sunzi bingfa", a lot of works involving management theories and practices came about in ancient China, among which "Zhouli" ( Rites of the Chou Dynasty ), " Guanzi" ( Works of Guanzi ), "Huozhi liezhuan" ( Biographies of money makers), "Mengxi bitan" ( A collection of miscellanea), and "Tiangong kaiwu" ( Exploitation of the works of nature) are representative. The insights from those works guided the way Chi- nese people managed in many fields, and exerted great impact on management practices for thousand years in Chi- na. Although China was highly developed in Han and Tang Dynasties, due to the constraints of language, geogra- phy, transforation, information, small- scale production mode, national condition, etc, Chinese management theo- ries hardly produced any worldwide impact. Since the 14th century, with Europe's Renaissance, sprout of capitalist productive relationship, concentration of factory production, as well as urban prosperity promoted

  10. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2004-04-01

    Full Text Available -Timothy P. Barnard, Cynthia Chou, Indonesian sea nomads; Money, magic, and fear of the Orang Suku Laut. London: RoutledgeCurzon, 2003, xii + 159 pp. -R.H. Barnes, Toos van Dijk, Gouden eiland in de Bandazee; Socio-kosmische ideeën op Marsela, Maluku Tenggara, Indonesië. Leiden: Onderzoekschool voor Aziatische, Afrikaanse en Amerindische studies (CNWS, Universiteit Leiden, 2000, 458 pp. [CNWS Publications 94.] -Andrew Beatty, Peter G. Riddell, Islam and the Malay-Indonesian world; Transmission and responses. Honolulu: University of Hawai'i Press, 2001, xvii + 349 pp. -Peter Boomgaard, Richard H. Grove ,El Niño - history and crisis; Studies from the Asia-Pacific region. Cambridge: White Horse Press, 2000, 230 pp., John Chappell (eds -Bernardita Reyes Churchill, Florentino Rodao, Franco y el imperio japonés; Imágenes y propaganda en tiempos de guerra. Barcelona: Plaza and Janés, 2002, 669 pp. -Matthew Cohen, Stuart Robson, The Kraton; Selected essays on Javanese courts. Translated by Rosemary Robson-McKillop. Leiden: KITLV Press, 2003, xxvi + 397 pp. [Translation series 28.] -Serge Dunis, Ben Finney, Sailing in the wake of the ancestors; Reviving Polynesian voyaging. Honolulu: Bishop Museum Press, 2003, 176 pp. [Legacy of excellence.] -Heleen Gall, Jan A. Somers, De VOC als volkenrechtelijke actor. Deventer: Gouda Quint, Rotterdam: Sanders Instituut, 2001, x + 350 pp. -David Henley, Harold Brookfield, Exploring agrodiversity. New York: Columbia University Press, 2001, xix + 348 pp. -David Hicks, Ernst van Veen ,A guide to the sources of the history of Dutch-Portuguese relations in Asia (1594-1797. With a foreword by Leonard Blussé. Leiden: Institute for the history of European expansion, 2001, iv + 378 pp. [Intercontinenta 24.], Daniël Klijn (eds -Nico Kaptein, Donald J. Porter, Managing politics and Islam in Indonesia. London: RoutledgeCurzon, 2002, xxi + 264 pp. -Victor T. King, Monica Janowski, The forest, source of life; The Kelabit of

  11. Wood textures in Jinman copper deposit in western Yunnan and their genetic implications

    Institute of Scientific and Technical Information of China (English)

    LIU; Jiajun

    2001-01-01

    [1]Shuai Dequan, On the biological textures of metallic minerals, Acta Mineralogica and Petrologica (in Chinese with Eng-lish abstract), 1985, 5(4): 80-84.[2]Shuai Dequan, On the Biological Fabrics of Metallic Minerals (in Chinese), Chengdu: Sichuan University Press, 1988, 70-76.[3]Picot, P., Johan, Z., Atlas of Ore Minerals (in German), 2nd ed., Amsterdam: B.R.G.M.Elsevier, 1980, 455.[4]Ramdohr, P., The Ore Minerals and Their Intergrodoths, 2nd ed., (English translation of the 4th edition, with additions and corrections by the authors), Vol. 2, Oxford: Pergamon Press, 1980, 164-1062.[5]Ramdohr, P., The Ore Minerals and Their Intergrodoths (in German), Berlin: Springer-Verlag, 1975.[6]Picot, P., Johan, Z., Atlas of Ore Minerals (Translation by Guiloux, J., Reviewed by Watkinson, D. H.), Amsterdam: B.R.G.M.Elsevier, 1982, 54.[7]Yan Wen, Li Chaoyang, Geochemical characteristics and hydrothermal sedimentary origin of a new type of copper depos-its, Geochimica (in Chinese with English abstract), 1997, 26(1): 55-63.[8]Shi Xingjian, Li Xingxue, Plant Fossils in China (in Chinese), Vol. 2, Beijing: Science Press, 1963, 341.[9]Ji Hongbing, Li Chaoyang, Geochemical characteristics and origin of ore-forming fluids in Jinman copper deposit, west-ern Yunnan, Acta Mineralogica Sinica (in Chinese with English abstract), 1998, 18(1): 28-37.[10]Zhuang Hanping, Ran Chongying, He Mingqing et al., Interactions between copper, salt and organic matter and the for-mation of sandstone-hosted copper deposits, Acta Geologica Sinica (in Chinese with English abstract), 1996, 70(2): 162-172.[11]Yang Yingxuan, Chou Dingmao, Kan Meiying et al., Precambrian Stratabound Copper Deposits in Xichang-Central Yun-nan (in Chinese), Chongqing: Chongqing Publishing House, 1988, 291-299.[12]Li Feng, Pu Weimin, Ran Chongying, Ore-forming material source of Jinman copper deposit in Lanping, western Yunnan, Bulletin of Kunming College of Technology (in Chinese

  12. Kinetics and rate-limiting mechanisms of dolomitedissolution at various CO2 partial pressures

    Institute of Scientific and Technical Information of China (English)

    LIU; Zaihua

    2001-01-01

    [1]Lund, K., Fogler, H. S., McCune, C. C., Acidization I. The dissolution of dolomite in hydrochloric acid, Chem. Eng.Sci., 1973.28: 691-700.[2]Herman, J. S., The dissolution kinetics of calcite, dolomite and dolomite rocks in carbon dioxide water system, PH. D.Thes., Pennsylvania State Univ., 1982.[3]Busenberg, E., Plummer, L. N., The kinetics of dissolution of dolomite in CO2-H2O systems at 1.5 to 65℃ and 0 to 1atm Pco2, Amer. Jour. Sci., 1982, 282: 45-78.[4]Chou, L., Garrels, R. M., Wollast, R., Comparative study of the kinetics and mechanisms of dissolution of carbonate minerals, Chem. Geol., 1989, 78: 269-282.[5]Liu, Z., Yuan, D., He, S. et al. Geochemical features of the geothermal CO2-water-carbonate rock system and analysis on its CO2 Sources, Science in China, Series D, 2000, 43(6): 569-576.[6]Shangguan, Z., Bai, C., Sun M., Mantle-derived magmatic gas releasing features at the Rehai area, Tengchong County,Yunnan Province, China, Science in China, Series D, 2000, 43(2): 132-140.[7]Dreybrodt, W., Lauckner, J., Liu, Z. et al., The kinetics of the reaction CO2+ H2O→H++ HCO3-as one of the rate limiting steps for the dissolution of calcite in the system H2O-CO2-CaCO3, Geochim. Cosmochim. Acta, 1996, 60:3375-3381.[8]Liu, Z., Dreybrodt, W., Dissolution kinetics of calcium carbonate minerals in H2O-CO2 solutions in turbulent flow: the roleof the diffusion boundary layer and the slow reaction H2O+CO2→H++HCO3-, Geochim. Cosmochim. Acta, 1997, 61:2879-2889.[9]Dreybrodt, W., Eisenlohr, L., Madry, B. et al., Precipitation kinetics of calcite in the system CaCO3-H2O-CO2: The conversion to CO2 by the slow process H++HCO3-~ CO2 + H2O as a rate limiting step, Geochim. Cosmochim. Acta, 1997,61: 3897-3904.[10]Dreybrodt, W., Buhmann, D., A mass transfer model for dissolution and precipitation of calcite from solutions in turbulent motion, Chem. Geol., 1991, 90: 107-122.[11]Dreybrodt, W., Processes in Karst Systems, Springer

  13. Atmospheric response to a realistic coastal polynya in Terra Nova Bay (Antarctica) simulated by ETA model.

    Science.gov (United States)

    Morelli, S.; Casini, G.; Parmiggiani, F.

    2009-04-01

    2006 both with and without the polynya (as derived by satellite image) included in the initial conditions. Results from these experiments will be presented. Simulations were performed with 50 layers in the vertical from sea surface to 25 hPa, with higher resolution near the bottom of the domain. Horizontal resolution was 0,125x0,125 transformed degrees (about 20kmx20km). Numerical simulations show that the polynya had significant effects on temperature, specific humidity, vertical velocity and horizontal wind speed throughout the boundary layer. The effects are found over and downwind the sea ice free area. The presence of polynya produced significant thermal modifications in atmosphere. Turbulent kinetic energy also responded to its presence and the low level wind speed changed over the open water area. References: Casini, G., Morelli, S. (2007) ‘Katabatic wind and Terra Nova Bay polynya: a study using two different versions of ETA model', Geophysical Research Abstract, vol. 9, 02656. De Carolis G., Morelli, S., Parmiggiani, F., and Casini G. (2006) ‘Terra Nova Bay polynya: a study by satellite microwave observations and Eta model simulations',Geophysical Research Abstract, vol. 8, 08433 Mesinger F., Jovic D., Sin Chan Chou, Gomes J.L., Bustamante J.F. (2006) ‘Wind forecast around the andes using the sloping discretization of the Eta coordinate', Proceedings of 8 ICSHMO, Foz do Iguacu, Brazil, 24-28 April 2006, INPE. Morelli S., Casini G., Parmiggiani F. (2007) ‘Wintertime katabatic event and polynya at Terra Nova Bay: a study by ETA simulations and AMSR-E images', Extended Abstract of 2nd Antarctic Meteorological Observation, Modeling and Forecasting (AMOMF) Workshop, June 2007. Morelli S., Casini G. (2008) ‘Antarctic katabatic winds and their interaction with a coastal polynya in Terra Nova Bay, studied by ETA model simulations and satellite images', Geophysical Research Abstract, vol. 10. Morelli S. (2008) ‘ETA Model simulation of winter katabatic

  14. CENOZOIC VOLCANISM AND GEOTHERMAL RESOURCES IN NORTHEAST CHINA

    Institute of Scientific and Technical Information of China (English)

    WANG; Xi-kui

    2001-01-01

    [1]CHEN Pan-qin. 1992. The Core Project of International Research of Global Changes (1) [M]. Beijing: Atmosphere Publishing House, 70. (in Chinese)[2]Committee of National Natural Science Foundation of China, 1995. Geography Science[M]. Beinjing: Science Press,105. (in Chinese)[3]HUMHREY J D, FERRING C R , 1994. Stable isotopic evidence for latest pleistocene and central Holocene climatic change in north Texas[J]. Quaternary Research, 41:200-213.[4]GUAN You-zhi, LI Zhi-zhong, 1994. The distribution of geochemical elementin and paleoclimate in the Holocene sediment, northern part of Taklimakan desert[J]. Arid Land Geography, 17(3): 19-26. (in Chinese)[5]LIJia-lin, 1988. Guide to Geochemstry[M]. Lanzhou: Lanzhou University Press, 88-92. (in Chinese)[6]LIU Yin-jun, 1984. Element Geochemistry[M]. Beijing: Science Press. (in Chinese)[7]OLDFIELD F, 1991. Environmental Magnetism-a personal prospective[J]. Quaternary Science Review, 10:73-85.[8]SUN Xiang-jun, DU Nai-qiu, WEN Chen-yu et al., 1994, Paleovegetation and paleoenvironment of Mamas Lake, Xinjiang,N. W. China, during the last 14000 years[J]. Quaternary Sciences, 3:239-247. (in Chinese)[9]WU Jin-lu, 1997. Composition of the stable authigenic isotope of carbonate of RM core and its paleoclimatic implication in Tibetan plateau[J]. Scientia Geographica Sinica, 17(1):18 - 22. (in Chinese)[10]YIN Ze-sheng, YANG Yi-chou, WANG Shou-chun, 1993.Holocence environmental changes and Human being' s civilization in arid northwestern China[A]. In: ZHANG Lan-sheng(ed. ). Research on Living Environmental Changes in China During Historic Period[C]. Beijing: Ocean Press,260-283. (in Chinese)[11]YAO Tan-dong, SHI Ya-feng, THOMPSON L G et al., 1992.Climatic changes of Holocene reflected in the ice core from Dunde[A]. In: SHI Ya-feng. The Climates and Environments of Holocenc Megathermal in China[C]. Beijing: China Ocean Press, 206-210. (in Chinese)[12]YAO Tan-dong, YANG Zhi-hong, JIAO

  15. Petrological, geochemical and isotopic characteristics of lignite and calcified lignite from mining area Pesje, Velenje Basin, Slovenia

    Science.gov (United States)

    Vrabec, Mirijam; Markič, Miloš; Vrabec, Marko; Jaćimović, Radojko; Kanduč, Tjaša

    2014-05-01

    energy dispersive X-ray spectroscopy at the Department of Ceramics at the Jožef Stefan Institute. Geochemical characteristics of major and trace elements indicate that the values of major and trace elements are comparable to world average coal (Zhang et al., 2004). Isotopic composition of carbon and isotopic composition of nitrogen of investigated samples indicate values from to -29.4o to -23.7o and 1.8o to 5.9o respectively. Lower value of isotopic composition of carbon indicates higher gelification (values up to -29.4) and higher value of isotopic composition of nitrogen (values up to 5.9) indicate higher mineralization. The results of SEM/EDXS microscopy revealed that in calcified lignite chemical composition of calcite prevails. Traces of diagenetic pyrite were also found, indicating localized anoxic conditions during sedimentation. Values of isotopic composition of CCaCO3 range from -2 to +13 and indicate temperature of precipitation from 17.3 to 35 deg C, which is similar to results obtained in previous studies (Kanduč et al., 2012). References Krantz, D.E., Williams, D.F., Jones, D.S., 1987: Ecological and paleoenvironmental information using stable isotope profiles from living and fossil mollusks. Palaeogeography, Palaeoclimatology, Palaeoecology 58, 249-266. Kanduč T., Markič M., Zavšek S., McIntosh J. 2012: carbon cycling in the Pliocene Velenje Coal Basin, Slovenia, inferred from stable carbon isotopes. International Journal of Coal Geology 89, 70-83. Jaćimović, R., Lazaru, A., Mihajlović, D., Ilić, R., Stafilov, T., 2002: Determination of major and trace elements in some minerals by k0-instrumental neutron activation analysis. Journal of Radioanalytical Nuclear Chemistry, 253, 427-434. McCrea, JM., 1950. On the isotopic chemistry of carbonates and a paleotemperature scale. Journal of Chemical Physics 18, 849. Ward C.R. (Ed.), 1984: Coal Geology and Coal Technology. Black-well, Oxford, 345 pp. Zhang J.Y., Zheng C.G., Ren D.Y., Chou C.L., Zheng R

  16. PGE geochemistry of Jiding ophiolite in Tibet and its constraint on mantle processes

    Institute of Scientific and Technical Information of China (English)

    XIA; Bin

    2001-01-01

    [1]Naldrett, A. J., Duke, J. M., Platinum mentals in magmatic sulfide ores, Science, 1980, 208:1417-1424.[2]Fleet. M. E.. Crocket, J. H., Lin, M. H. et al., Laboratory partitioning of platinum-group elements and gold with application to magmatic sulfide-PGE deposits, Lithos, 1999, 47: 127-142.[3]Lorand, J. P., Fractionation of PGE and gold in the upper mantle: adetailed study in Pyrenean orogenic lherzolites, J. Petrol., 1999.40:957 - 981.[4]Xu. Yigang, Orberger, B., Reeves, S. J., Differentiation of PGE of upper mantle: The evidence of Wangqing peridotite inclusions in Jilin Province, Science in China, Ser. D, 1998, 41(4): 354-361.[5]Chou, M. F., Sun, M., Keays, R. R. et al., Controls on platinum-group elemental distributions of podiform chromitites: A case study of high-Cr and high-Al chromiform Chinese orogenic belts, Geochim. Cosmochim. Acta, 1998, 62: 677-688.[6]Pattou, L., Lorand, J. L., Gros, M., Non-chondritic platinum-group element ratios in the earth's mantle, Nature, 1996, 379:712-715.[7]Yu, H. X., Xia, B., Mei. H. J. et al., The PGE distribution characteristics of mantle peridotites in the Dazhuka ophiolite,Tibet. China. Chinese Science Bulletin, 2000, 45(22): 2446-2452.[8]Xiao, X. C., The Xigaze ophiolite of southern Xizang (Tibet) and its relevant tectionic problems, in Sino-French Cooperative Investigation in Himalayas (in Chinese) (eds. Li, G. C., Mercier, J. L.), Beijing: Geological Publishing House, 1980,143-168.[9]Wang, X. B., Bao, P. S., Deng, W. M. el al., Ophiolite of Xizang (in Chinese), Beijing: Geological Publishing House, 1987,2-29.[10]Wang, X. B., Chao, Y. G., Zheng, H. X., The sequence of ophiolte and the evolution modern of Yarlung Zangbo River(Middle Segment), (eds. Li, G. C., Mercier, J. L.), Sino-French Cooperative Investigation in Himalayas (in Chinese), Beijing: Geological Publishing House, 1980, 115-143.[11]Xia, B., Wang, G. Q., Zhong, F. T. et al., Instruction for Ophiolite and

  17. « Mr Azn@r, parT »

    Directory of Open Access Journals (Sweden)

    Ludivine Thouverez

    2004-09-01

    Full Text Available Les attentats du 11 mars 2004 à Madrid ont illustré le divorce existant entre les médias et la société civile espagnole. En fonctionnant comme de simple courroies de transmission du discours gouvernemental (lequel souhaitait incriminer l'ETA pour ne pas perdre les élections, les médias ont échoué dans leur mission de rendre une information libre et plurielle de la res publica. Durant la crise, les NTIC, nouvelles technologies de l'information et de la communication, ont joué un rôle de contre-pouvoir médiatique et social. La communication horizontale permit aux opinions divergentes de pouvoir s'exprimer. En outre, les NTIC favorisèrent les mobilisations citoyennes de la veille des élections. L'alliance NTIC - civils peut-elle mettre fin à la manipulation de l'information ? Va-t-elle obliger les hommes politiques et les médias traditionnels à une plus grande transparence ? Va-t-elle révolutionner les pratiques démocratiques ? Le terrorisme et son traitement médiatique sont des sujets complexes. Ils sont basés sur des intérêts contraires et s'inscrivent dans un contexte sociopolitique qui conditionne le discours de la presse sur l'acte terroriste. Si les nouvelles technologies élargissent le champ de l'espace public, elles n'offrent guère de solutions quant aux problèmes que rencontrent les journalistes en cas de terrorisme.Los atentados del 11-M en Madrid evidenciaron un divorcio entre los medios de comunicación y la sociedad civil española. Al funcionar como meras correas de transmisión del discurso del poder político (el cual quería incriminar a ETA para no perder las elecciones los medias fallaron en su misión de transmitir una información libre y plural de la res publica. Durante la crisis, las NTIC, nuevas tecnologías de la información y de la comunicación actuaron como contrapoder social y mediático. La comunicación horizontal permitió que se pudieran expresar opiniones contrarias a las del gobierno

  18. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Neonatology and NICU clinical care and practices”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    Full Text Available Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Neonatology and NICU clinical care and practices”ABS 1. BILATERAL CLAVICLE FRACTURE: A RARE CAUSE OF PERSISTENT CRYING • P. Cruz, P. Mendes, M. Anselmo, L. GonçalvesABS 2. NEONATAL TRANSPORT DURATION AND SHORT-TERM OUTCOME IN VERY-LOW-GESTATIONAL-AGE NEONATES • A. Matic, M. Gavrilovic LatinovicABS 3. PEMPHIGOID GESTATIONIS – A RARE CASE IN TWIN PREGNANCY • L. Gonçalves, E. Scortenschi, P. Cruz, P. Mendes, M. AnselmoABS 4. DEVELOPMENT OF A CLINICIAN-REPORTED OUTCOME (ClinRO MEASURE TO ASSESS READINESS FOR DISCHARGE FROM NEONATAL CARE AMONG EXTREMELY PRETERM INFANTS • M. Turner, R. Ward, J. Higginson, I. Hansen-Pupp, M. Vanya, E. Flood, G. Quiggle, A. Tocoian, A. Mangili, N. Barton, S. SardaABS 5. THE EFFECT OF THYROID HORMONES ON NICU ADMISSION DUE TO TRANSIENT TACHYPNEA OF NEWBORN IN LATE PRETERM AND TERM INFANTS • T. Gursoy, S. Ercin, P. Kayiran, B. GurakanABS 6. IMPROVING THE QUALITY OF PROLONGED JAUNDICE WORK-UPS IN THE OUTPATIENT DEPARTMENT IN A TERTIARY NEONATAL CENTRE • C.M. Moore, J. O’Loughlin, B.C. HayesABS 7. SAVE THE DATE? CORRECT RECORDING OF DAY OF LIFE AND CORRECTED GESTATIONAL AGE IN NICU • C.M. Moore, A.F. El-KhuffashABS 8. PARENTS IN NICU: THE IMPORTANCE OF INTEGRATION BETWEEN THE CURE AND THE CARE • G. De Bernardo, M. Svelto, M. Giordano, D. SordinoABS 9. THE PREVALENCE OF HEREDITARY HEARING LOSS IN 41,152 NEWBORNS DURING THE PERIOD 2011-2015 • S.T. Hsu, C.C. Hung, Y.N. Su, C.Y. Chen, H.C. Chou, W.S. Hsieh, C.C. Wu, P.N. TsaoABS 10. DEFICIENCY OF MULTIPLE acyl-CoA DEHYDROGENASE OR GLUTARIC ACIDURIA TYPE II • M. Torres, L. Geronès, J. Herrero, M.C. Cèspedes, F. Camba, J.A. Arranz, M. del Toro, F. CastilloABS 11. TEN YEARS OF EXPERIENCE IN CARRIER SCREENING FOR SPINAL MUSCULAR ATROPHY IN TAIWAN • C.Y. Chuang, C.C. Hung, Y.N. Su, P.N. TsaoABS 12. REDUCING MEDICATION ERRORS ON THE

  19. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Epidemiology, perinatology and DOHaD”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    Full Text Available Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Epidemiology, perinatology and DOHaD”ABS 1. THE INFLUENCE OF MATERNAL PREGESTATIONAL OBESITY IN OFFSPRING. A NEW PUBLIC HEALTH PROBLEM • P. Priego, N. Sancho, I. Tofe, A. Torre, M.D. CañeteABS 2. UNPLANNED NEONATAL ADMISSION RATE AFTER ELECTIVE FAMILY CENTERED CAESAREAN SECTIONS • I.C. Narayen, E.E.M. Mulder, L.M. Freeman, J.J. Van Vonderen, K.E. Boers, A.B. Te PasABS 3. CESAREAN DELIVERY AMONG FOREIGN-BORN CHINESE AND US-BORN CHINESE WOMEN IN THE USA • T.A. Yen, M. Lahiff, N. Hosang, K. Harley, B. EskenaziABS 4. THE RELATION BETWEEN OUTDOOR AIR POLLUTION AND SUDDEN INFANT DEATH SYNDROME – A POPULATION-BASED CASE-CONTROL STUDY • Y.S. Chang, C.H. Liu, P.N. Tsao, P.S. ChenABS 5. LONGITUDINAL GROWTH OF TURKISH VERY LOW BIRTH WEIGHT INFANTS • S. Sancak, M. Hayran, T. Gursoy, F. OvalıABS 6. FETAL SONOGRAPHIC FINDINGS IN A CONFIRMED CASE OF BECKWITH-WIEDEMANN SYNDROME (BWS • M.D. Ordónez Díaz, M.A. Pino Gálvez, C. De la Cámara Morano, D. Trassierra Molina, M.P. Priego Ruiz, M.J. Párraga Quiles, A.B. López Marmol, J.L. Pérez Navero, M. Miño MoraABS 7. CORD BLOOD PENTRAXIN 3/CD36 IN FETAL MACROSOMIA • T. Boutsikou, K. Germanou, D.D. Briana, M. Boutsikou, N. Athanasopoulos, A. Marmarinos, D. Gourgiotis, A. Malamitsi-PuchnerABS 8. NEWBORN GENETIC SCREENING FOR CONGENITAL CENTRAL HYPOVENTILATION SYNDROME IN 41,152 NEWBORNS • P.C. Kuo, C.C. Hung, Y.N. Su, C.Y. Chen, H.C. Chou, W.S. Hsieh, P.N. TsaoABS 9. OFFSPRING OF DIABETIC MOTHER: THE IMPORTANCE OF MATERNAL GLYCEMIC CONTROL • M. Miñambres Rodríguez, A. Pino Vázquez, C. Villa Francisco, I. Sanz Fernández, M. Brezmes Raposo, L. C. Bermúdez BarrezuetaABS 10. PREVALENCE AND PRENATAL DIAGNOSIS OF CONGENITAL MALFORMATIONS IN A TERTIARY HOSPITAL • M.P. Priego Ruiz, M.D. Ordónez Díaz, M.V. Rodriguez Benitez, D. Trassierra Molina, L. Rueda García, J.L. P

  20. Un populisme de la misère : Haïti sous la présidence Aristide (1990-2004

    Directory of Open Access Journals (Sweden)

    Laurent Jalabert

    2005-09-01

    Full Text Available Elu en 1990 à l’issue d’un grand mouvement populaire en sa faveur en déclarant vouloir faire passer son pays de la « misère indigne à la pauvreté digne », Jean-Bertrand Aristide a quitté son pays en 2004, 3 ans après une réélection contestée, laissant Haïti dans une situation économique et sociale dégradée. Son exercice du pouvoir s’assimile à un « populisme moderne » qui s’est constitué lentement dans le contexte d’une transition démocratique incertaine. Populiste moderne, il utilise tous les moyens pour rester au pouvoir : corruption, milices de jeunes fanatisés, diabolisation des Etats occidentaux, exhortation du peuple… Il a aussi fait appel aux méthodes habituelles du leader populiste : encadrement de la société par la terreur, les médias, le parti, la fraude électorale, la corruption…. Son échec provient des limites de ses soutiens (milices armées incontrôlables, poids et rôle incertains des mafias de la drogue, division interne à son parti, faiblesse de la police, absence d’armée, isolement international. Dans ce contexte, malgré la terreur imposée aux intellectuels et à l’opposition, il n’a pas su empêcher la montée en puissance des mécontentements. Le peuple, manipulé, n’a plus cru en son Président dès les années 2002-2003. Porté par les masses des bidonvilles au pouvoir, Aristide n’a pas répondu à leur attente. Il s’est mis dans la peau d’un populiste sans imagination. Il a échoué dans tous les domaines, sombrant dans une démagogie et un discours sans prise sur l’opinion. Le régime d’Aristide ne fut qu’un populisme de misère, indigne, pour un peuple digne toujours en quête de démocratie.Jean-Bertrand Aristide había sido elegido presidente en 1990 merced a un gran movimiento popular a su favor, cuando declaraba querer llevar a su país « de la miseria indigna a la pobreza digna ». En el 2004, 3 años después de una reelección pol

  1. Avaluació de la qualitat docent i promoció del professorat. Legislació universitària espanyola: de la Llei de reforma universitària (1983 a la Llei orgànica d'universitats

    Directory of Open Access Journals (Sweden)

    Josep Carreras

    2005-01-01

    enseignement et de la recherche, ce qui impliqua la mise en place d’un ensemble de critères destinés à évaluer l’activité des professeurs. Cependant, sept ans après l’entrée en vigueur de la LRU, l’idée qu’il fallait modifi er le système de sélection des professeurs faisait déjà l’objet d’un large consensus. On était arrivé en effet à un tel degré d’endogamie que les concours de recrutement se résolvaient pratiquement toujours en faveur des candidats locaux, quels que soient les mérites des uns et des autres. Face à cette situation, le gouvernement socialiste de l’époque essaya à plusieurs reprises de modifi er la loi mais toutes les tentatives échouèrent faute de parvenir au consensus nécessaire au Parlement. C’est donc un gouvernement du Parti Populaire qui en 2002, grâce au soutien de sa majorité absolue et malgré les fortes protestations de l’opposition politique et des diverses représentations du monde universitaire, fi t voter une nouvelle Loi organique des Universités (LOU modifi ant sensiblement les mécanismes de recrutement des professeurs et impliquant une perte d’autonomie des universités espagnoles.Following the publication of the University Reform Act (Ley de Reforma Universitària - LRU in 1983, the complementary decrees that allowed the provision of numerous posts in the various teaching bodies, in accordance with the new criteria included in the Act, were also promulgated. In addition, complementary payments were esta blished as an incentive to the teaching and research of university lecturers, and consequently the universities started to apply procedures for the evaluation of teaching. However, seven years after the LRU was esta blished it was generally held that the system for selecting lecturers needed to be changed; above all because of the high degree of endogamy that had been allowed to develop, to the extent that it was usually the local candidates that were awarded the post regardless of merit. With

  2. The effectiveness of music on pain among preterm infants in the neonatal intensive care unit: a systematic review.

    Science.gov (United States)

    Pölkki, Tarja; Korhonen, Anne

    2012-01-01

    BA), and music as an auditory stimulus not exceed 75 dB in NICU. If earphones or other devices are used, sound sources should be kept at reasonable distances from the infant's ear, played for brief periods and at levels below 55 dB.Music listening can be initiated with or without the involvement of a music therapist. In this review, music can be implemented for premature infants by a music therapist or any health care providers and it will include both recorded and live music. Regardless of the type of music, several studies have investigated the short term effects of music on preterm infants, including the improvement in physiological outcomes (e.g. oxygen saturation, heart rate, respiratory rate, and blood pressure), as well as in behavioural state (e.g. crying, facial expression, body movements) and pain scores. For example, Chou et al. showed that premature infants receiving recorded music, that was the combination of womb sounds and the mother singing, with endotracheal suctioning had significantly higher oxygen saturation than when they did not receive music. Butt & Kisilewsky compared recorded music involving both the vocal and instrumental version of Brahms lullaby versus no music, and found that infants older than 31 weeks demonstrated significant reduction in heart rate, behavioral state and pain.In the study of Arnon et al. the infants receiving live music, compared with infants receiving recorded music or no music, had significantly reduced heart rate and behavioral scores during the post-intervention period. Live music comprised of a lullaby sang by the female voice with frame drum and an accompanying harp. The same music was played by a tape recorder. Live music showed significant benefits, whereas no statistically significant changes were found for the recorded music and control groups. Teckenberg-Jansson et al. indicated that music therapy combined with kangaroo care decreased the pulse, slowed down the respiration and increased the transcutaneous oxygen

  3. Out-of-Sequence Thrust in the Higher Himalaya- a Review & Possible Genesis

    Science.gov (United States)

    Mukherjee, S.; Koyi, H. A.; Talbot, C. J.

    2009-04-01

    : evidences from fission track dating. Earth Planetary Science Letters 179, 437-451. Mukherjee, S. 2007. Geodynamics, deformation and mathematical analysis of metamorphic belts of the NW Himalaya. Unpublished Ph.D. thesis. Indian Institute of Technology Roorkee. pp. 1-267. Searle, M.P., 1999. Extensional and compressional faults in the Everest-Lhotse massif, Khumbu Himalaya, Nepal. Journal of Geological Society, London, 156, 227-240. Swapp, S.M., Hollister, L.S., 1991. Inverted metamorphism within the Tibetan slab of Bhutan: evidence for a tectonically transported heat source. Canadian Mineralogist 29, 1019-1041. Vannay, J-C., Hodges, K.V., 1996. Tectonomorphic evolution of the Himalayan metamorphic core between the Annapurna and Dhaulagiri, central Nepal. Journal of Metamorphic Geology 14, 635-656. Wobus, C., Heimsath, A., Whipple, K., Hodges, K., 2005. Active out-of-sequence thrust faulting in the central Nepalese Himalaya. Nature 434, 1008-1011. Yin, A., Dubey, C.S., Kelty, T.K., Gehrels, G.E., Chou, C.Y., Grove, M., Lovera, O., 2006. Structural evolution of the Arunachal Himalaya and implications for asymmetric development Himalayan orogen. Current Science 90, 195-206.

  4. Efficacy and Safety of Intravenous Sodium Valproate in Convulsive Status Epilepticus in Children in Shahid Sadoughi Hospital

    Directory of Open Access Journals (Sweden)

    Razieh FALLAH

    2012-06-01

    ;29(1:51-64. Mikati MA. Status epilepticus. In: Kliegman RM, Stanton BF, Schor NF, St. Geme JW, Behrman RE. Nelson textbook of pediatrics. 19th ed. Philadelphia: Saunders; 2011. P. 2013-7. Nair PP, Kalita J, Misra UK. Status epilepticus: Why, what, and how. J Postgrad Med 2011;57(3:242-52. Saz EU, Karapinar B, Ozcetin M, Polat M, Tosun A, Serdaroglu G et al. Convulsive status epilepticus in children: etiology, treatment protocol and outcome. Seizure 2011;20(2:115-8. Nam SH, Lee BL, Lee CG, Yu HJ, Joo EY, Lee J et al. The role of ketogenic diet in the treatment of refractory status epilepticus. Epilepsia 2011;52(11:e181-4. Shiloh-Malawsky Y, Fan Z, Greenwood R, Tennison M. Successful treatment of childhood prolonged refractory status epilepticus with lacosamide. Seizure 2011;20(7:586-8. Abend NS, Monk HM, Licht DJ, Dlugos DJ. Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures. Pediatr Crit Care Med 2009;10(4:505-10. Chang YC, Lin JJ, Wang HS, Chou ML, Hung PC, Hsieh MY. Intravenous valproate for seizures in 137 Taiwanese children - valproate naive and non-naive. Acta Neurol Taiwan 2010;19(2:100-6. Wheless JW, Vazquez BR, Kanner AM, Ramsay RE, Morton L, Pellock JM. Rapid infusion with valproate sodium is well tolerated in patients with epilepsy. Neurology 2004;63(8:1507-8. Sofou K, Kristjánsdóttir R, Papachatzakis NE, Ahmadzadeh A, Uvebrant P. Management of prolonged seizures and status epilepticus in childhood: a systematic review. J Child Neurol 2009;24(8:918-26. Visudtibhan A, Bhudhisawadi K, Vaewpanich J, Chulavatnatol S, Kaojareon S. Pharmacokinetics and clinical application of intravenous valproate in Thai epileptic children. Brain Dev 2011;33(3:189-94. Kälviäinen R, Eriksson K, Parviainen I. Refractory generalised convulsive status epilepticus: a guide to treatment. CNS Drugs 2005;19(9:759-68. Arif H, Hirsch LJ. Treatment of status epilepticus. Semin Neurol 2008;28(3:342-54. Misra UK, Kalita J, Patel R. Sodium valproate

  5. The Clinical Features and Diagnosis of Canavan’s Disease: A Case Series of Iranian Patients

    Directory of Open Access Journals (Sweden)

    Parvaneh KARIMZADEH

    2014-12-01

    even with normal serum and urine N-acetylaspartic acid levels. ReferencesAdornato BT, O’Brien JS, Lampert PW, Roe TF, Neustein HB. Cerebral spongy degeneration of infancy. A biochemical and ultrastructural study of affected twins. Neurology 1972;22(2:202-10.Banker BQ, Robertson JT, Victor M. Spongy Degeneration of the Central Nervous System in Infancy. Neurology 1964; 14:981-1001.Chou SM, Waisman HA. Spongy Degeneration of the Central Nervous System: Case of Homocystinuria. Arch Pathol 1965; 79:357-63.Divry P, Vianey-Liaud C, Gay C, Macabeo V, Rapin F, Echenne B. N-acetylaspartic aciduria: report of three new cases in children with a neurological syndrome associating macrocephaly and leukodystrophy. J Inherit Metab Dis 1988; 11(3:307-8.Feigenbaum A, Moore R, Clarke J, Hewson S, Chitayat D, Ray PN, et al. Canavan disease: carrier-frequency determination in the Ashkenazi Jewish population and development of a novel molecular diagnostic assay. Am J Med Genet A 2004;124a(2:142-7.Hagenfeldt L, Bollgren I, Venizelos N. N-acetylaspartic aciduria due to aspartoacylase deficiency--a new aetiology of childhood leukodystrophy. J Inherit Metab Dis 1987; 10(2:135-41.Ishiyama G, Lopez I, Baloh RW, Ishiyama A. Canavan’s leukodystrophy is associated with defects in cochlear neurodevelopment and deafness. Neurology 2003; 60(10:1702-4.Janson CG, Kolodny EH, Zeng BJ, Raghavan S, Pastores G, Torres P, et al. Mild-onset presentation of Canavan’s disease associated with novel G212A point mutation in aspartoacylase gene. Ann Neurol 2006; 59(2:428-31.Kaul R, Gao GP, Aloya M, Balamurugan K, Petrosky A, Michals K, et al. Canavan disease: mutations among Jewish and non-Jewish patients. Am J Hum Genet 1994; 55(1:34-41.Kaul R, Gao GP, Balamurugan K, Matalon R. Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. Nat Genet 1993; 5(2:118-23.Kvittingen EA, Guldal G, Borsting S, Skalpe IO, Stokke O, Jellum E. N-acetylaspartic aciduria in a child with a

  6. Gouvernance de l’eau potable et dynamiques locales en zone rurale au Bénin

    Directory of Open Access Journals (Sweden)

    Bernard G. Hounmenou

    2006-05-01

    Full Text Available Dans la fourniture des services de base aux populations, les politiques publiques de plusieurs pays, en particulier celles des Pays en Voie de Développement (PED, ont connu ces dernières années une profonde mutation. Les changements les plus remarquables se rapportent à la remise en cause du service public gratuit. Outre la nécessité fondamentale pour les Etats d’assainir leurs économies, ces réformes visent à favoriser une participation des populations dans la conduite des opérations ayant pour objectif la satisfaction de leurs besoins. La question de la participation constitue actuellement un élément capital pour l’organisation des services au niveau communautaire. En effet, plusieurs expériences ont montré que les projets réalisés sans la participation des populations concernées ont échoué au moment de l’exécution ou, faute d’entretien, n’ont eu que des retombées éphémères (Banque Mondiale, 1994. Au Bénin, certaines opérations de développement, en particulier celles conduites dans le secteur de l’approvisionnement en eau potable des populations rurales, n’ont pas échappé à cette réalité. En effet, jusqu’à la fin des années 1980, plusieurs ouvrages d’approvisionnement en eau potable ont été construits par les pouvoirs publics, sans une réelle participation des communautés bénéficiaires en milieu rural béninois. Cette situation a occasionné un manque d’intérêt des populations, qui s’est exprimé par l’abandon des ouvrages en cas de panne, et le recours à l’utilisation de sources d’eau non potable. Pour y remédier, le Bénin a opté en 1992 pour une nouvelle stratégie nationale d’alimentation en eau potable. La stratégie a pour objectif l’implication des populations du monde rural dans tout le processus d’appropriation de l’alimentation en eau. Les principes fondamentaux de cette stratégie sont notamment, la décentralisation du processus de prise de d

  7. Avaluació de la qualitat docent i promoció de professorat universitari

    Directory of Open Access Journals (Sweden)

    Josep Carreras

    2004-01-01

    contenues dans ces trois textes avaient des éléments qui permettaient d’évaluer certains aspects de la qualité de l’enseignement des candidats; mais, pendant toute la période où ils ont été en vigueur, il n’y a pas eu à l’université de pratiques habituelles et généralisées quant à l’évaluation de l’enseignement supérieur. Ceci était dû aussi bien à la faible propension des professeurs du supérieur à être évalués qu’à la persistance du système des concours pour accéder à la situation d’enseignant, à vie. Au cours des premières années de la transition démocratique, diverses tentatives ont été faites pour promulguer une loi qui adapterait les structures et les fonctions des universités à la nouvelle réalité socio-politique du pays. Toutefois, elles ont toutes échoué par manque d’appui parlementaire, jusqu’à ce qu’en 1983 le gouvernement socialiste ait promulgué la Loi de réforme universitaire. Cette loi, qui a régi la vie de l’Université espagnole pendant presque vingt ans, a ouvert de nouvelles perspectives d’évaluation de la qualité de l’enseignement pour la sélection et la promotion du professorat.During the years of Francoism, the Spanish universities were regulated successively by three different acts: the Spanish Universities Act of 1943, the University Faculties and Lecturers Act of 1965, and the General Education Act of 1970. The procedures for selecting faculty members provided for in each of these included elements that permitted various aspects of the teaching quality of candidates to be evaluated; but throughout the period in which these laws were in force, there were no generally established practices for evaluating university lecturers, due to the reluctance among the faculty members to subject themselves to evaluation and to the persistence of the competitive examination system for acceding to a teaching post that was assured for life. During the early years of the transition to

  8. Cervical insufficiency and cervical cerclage.

    Science.gov (United States)

    Brown, Richard; Gagnon, Robert; Delisle, Marie-France; Gagnon, Robert; Bujold, Emmanuel; Basso, Melanie; Bos, Hayley; Brown, Richard; Cooper, Stephanie; Crane, Joan; Davies, Gregory; Gouin, Katy; Menticoglou, Savas; Mundle, William; Pylypjuk, Christy; Roggensack, Anne; Sanderson, Frank; Senikas, Vyta

    2013-12-01

    risque de l’insuffisance cervicale. L’exécution d’une anamnèse exhaustive au moment de l’évaluation initiale pourrait attirer l’attention des cliniciens sur des facteurs de risque s’étant manifestés au cours d’une première grossesse (ou grossesse probante). (III-B) 2. Les femmes qui connaissent une fausse couche au deuxième trimestre ou un accouchement prématuré précoce devraient par la suite faire l’objet d’une évaluation détaillée des facteurs de risque; une telle évaluation devrait également être menée chez les femmes qui ont connu ces complications dans le cadre d’une grossesse précédente. (III-B) 3. Chez les femmes qui présentent des antécédents d’insuffisance cervicale, une analyse d’urine (à des fins de mise en culture et pour la tenue d’une épreuve de sensibilité) et des mises en culture vaginales visant la vaginose bactérienne devraient être effectuées dans le cadre de la première consultation obstétricale, et toute infection ainsi mise au jour devrait être traitée. (I-A) 4. Les femmes qui ont déjà connu au moins trois fausses couches au deuxième trimestre ou accouchements extrêmement prématurés et chez qui aucune cause particulière autre qu’une insuffisance cervicale potentielle n’a été identifiée devraient se voir offrir un cerclage planifié (à 12 - 14 semaines de gestation). (I-A) 5. Dans le cas des femmes présentant des antécédents classiques d’insuffisance cervicale chez qui la mise en place précédente d’un cerclage vaginal a échoué, la mise en place d’un cerclage abdominal peut être envisagée en l’absence de facteurs atténuants additionnels. (II-3C) 6. Les femmes qui ont subi une trachélectomie devraient faire l’objet d’un cerclage abdominal. (II-3C) 7. La mise en place d’un cerclage d’urgence pourrait être envisagée chez les femmes dont le col présente une dilatation grossesse monofœtale qui présentent une possible insuffisance cervicale ou des ant

  9. Randomised Clinical Efficacy Trial of Topiramate and Nitrazepam in Treatment of Infantile Spasms

    Directory of Open Access Journals (Sweden)

    Razieh FALLAH

    2014-01-01

    . Topiramate slow dose titration: improved efficacy and tolerability. Pediatr Neurol 2004;31(5:349-52.Hsieh MY, Lin KL, Wang HS, Chou ML, Hung PC, Chang MY. Low-dose topiramate is effective in the treatment of infantile spasms. Chang Gung Med J 2006;29(3:291-6.Auvichayapat N, Tassniyom S, Treerotphon S, Auvichayapat P. Treatment of infantile spasms with sodium valproate followed by benzodiazepines. J Med Assoc Thai 2007;90(9:1809-14.Karvelas G, Lortie A, Scantlebury MH, Duy PT, Cossette P, Carmant L. A retrospective study on aetiology based outcome of infantile spasms. Seizure 2009;18(3:197-201.Chen CC, Chen TF, Lin HC, Oon PC, Wu HM, Wang PJ, et al. Estimation of prevalence and incidence of infantile spasms in Taiwan using capture–recapture method. Epilepsy Res 2004;58(1:37–42.Parisi P, Bombardieri R, Curatolo P. Current role of vigabatrin in infantile spasms. Eur J Paediatr Neurol 2007;11(6:331-6.Cvitanović-Sojat L, Gjergja R, Sabol Z, Hajnzić TF, Sojat T. Treatment of West syndrome. Acta Med Croatica 2005;59(1:19-29. (Full text in CroatianWatemberg N, Goldberg-Stern H, Ben-Zeev B, Berger I, Straussberg R, Kivity S, et al. Clinical experience with open-label topiramate use in infants younger than 2 years of age. J Child Neurol 2003;18(4:258-62.Grosso S, Franzoni E, Iannetti P, Incorpora G, Cardinali C, Toldo I, et al. Efficacy and safety of topiramate in refractory epilepsy of childhood: long-term follow-up study. J Child Neurol 2005;20(11:893-7.Capovilla G, Beccaria F, Montagnini A, Cusmai R, Franzoni E, Moscano F, et al. Short-term nonhormonal and nonsteroid treatment in West syndrome. Epilepsia 2003;44(8:1085-8.Chamberlain MC. Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome. J Child Neurol 1996;11(1:31-4.28. Hosain SA, Green NS, Solomon GE, Chutorian A. Nitrazepam for the treatment of Lennox-Gastaut syndrome. Pediatr Neurol 2003;28(1:16-9.Rintahaka PJ, Nakegawa JA, Shewmom DA, Kyynnem P, Shields WD. Incidence of death in patients with

  10. EDITORIAL: Focus on Micro- and Nanofluidics FOCUS ON MICRO- AND NANOFLUIDICS

    Science.gov (United States)

    Ajdari, Armand; Stone, Howard A.

    2009-07-01

    , simulation and theory, in this rapidly developing field. Focus on Micro- and Nanofluidics Contents The anti-lotus leaf effect in nanohydrodynamic bump arrays Keith Morton, Ophelia K C Tsui, Chih-Kuan Tung, James C Sturm, Stephen Y Chou and Robert Austin Transport in nanofluidic systems: a review of theory and applications W Sparreboom, A van den Berg and J C T Eijkel The effects of polymer molecular weight on filament thinning and drop breakup in microchannels P E Arratia, L-A Cramer, J P Gollub and D J Durian Mass transfer and interfacial properties in two-phase microchannel flows Jeffrey D Martin and Steven D Hudson Temporal response of an initially deflected PDMS channel Priyadarshi Panda, Kai P Yuet, Dhananjay Dendukuri, T Alan Hatton and Patrick S Doyle Gas-liquid two-phase flow patterns in rectangular polymeric microchannels: effect of surface wetting properties D Huh, C-H Kuo, J B Grotberg and S Takayama Mixing via thermocapillary generation of flow patterns inside a microfluidic drop María Luisa Cordero, Hans Olav Rolfsnes, Daniel R Burnham, Paul A Campbell, David McGloin and Charles N Baroud Pressure-driven DNA transport across an artificial nanotopography J T Del Bonis-O'Donnell, W Reisner and D Stein Eulerian indicators for predicting and optimizing mixing quality Rob Sturman and Stephen Wiggins Asymmetric flows over symmetric surfaces: capacitive coupling in induced-charge electro-osmosis T S Mansuripur, A J Pascall and T M Squires High-viscosity fluid threads in weakly diffusive microfluidic systems T Cubaud and T G Mason Interfacial mass transport in steady three-dimensional flows in microchannels Joseph D Kirtland, Corey R Siegel and Abraham D Stroock Active connectors for microfluidic drops on demand Jean-Christophe Galas, Denis Bartolo and Vincent Studer Electrokinetic control of sample splitting at a channel bifurcation using isotachophoresis Alexandre Persat and Juan G Santiago Differential inertial focusing of particles in curved low

  11. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Brain and development”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    Full Text Available Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Brain and development”ABS 1. CRITICAL CONDITION OF THE FETUS: RISK FACTORS AND PERINATAL OUTCOMES • E. Timokhina, A. Strizhakov, K. DerishABS 2. A MID-STUDY SAFETY CONTROL IN A HYPOTHERMIA PLUS MELATONIN CLINICAL TRIAL • A. Jerez-Calero, E. Fernandez-Marin, L. Serrano-López, AR. Gonzalez-Ramirez, J. Uberos-Fernandez, E. Narbona-LópezABS 3. EARLY PREDICTORS OF NEURODEVELOPMENTAL OUTCOME IN ASPHYXIATED INFANTS TREATED WITH SELECTIVE HEAD COOLING • C.Y. Chen, P.N. Tsao, H.C. Chou, W.S. HsiehABS 4. PRENATAL SURGERY OF MYELOMENINGOCELE: IS IT WORTH DOING? • H. Villalon, M. Pinto, S. Hosiasson, F. Rybertt, A. Fernandez, D. Tuma, L. Pizarro, C. SilvaABS 5. NEONATAL CEREBRAL SINOVENOUS THROMBOSIS: TWO CASES, TWO DIFFERENT GENE POLYMORPHISMS AND RISK FACTORS • O. Turan, D. Anuk Ince, L. Olcay, T. Sezer, K. Gulleroglu, Z.Y. Çelik, A. EcevitABS 6. DEVELOPMENT OF PREMATURE BORN CHILDREN – WHAT ABOUT LANGUAGE, READING AND WRITING? THE SPEECH AND LANGUAGE PATHOLOGIST’S VIEW • Z. Kolundžić, M. Lenček, A. Šimić Klarić, K. Pavičić DokozaABS 7. CHARACTERISTICS AND DISCHARGE OUTCOMES OF INFANTS UNDERGOING THERAPEUTIC HYPOTHERMIA IN AMERICAN NICUs • K. Ellsworth, M. Harris, M. Ellsworth, W. Carey, A. Spitzer, R. ClarkABS 8. PERINATAL STROKE: A LEADING CAUSE OF SEIZURES IN THE NEONATAL PERIOD. 4 YEAR EXPERIENCE IN A TERTIARY NEONATAL INTENSIVE CARE UNIT • P. Mikrou, S. Hands, E. Mawondo, S.V. Rasiah, M. BorooahABS 9. CARRIER SCREENING FOR FRAGILE X SYNDROME IN TAIWAN FROM 2013 TO 2015 • W.C. Yang, C.C. Hung, Y.N. Su, P.N. TsaoABS 10. LENTICULOSTRIATE VASCULOPATHY IN NEONATES: CASES SERIES REPORT • M.P. Priego-Ruiz, D. Trassierra-Molina, M.P. Jaraba-Caballero, M.D. Ordóñez-Díaz, I.M. Tofé-ValeraABS 11. CONGENITAL HYDROCEPHALUS SECONDARY TO ARACHNOID CYST: CASE REPORT • M.P. Priego-Ruiz, I.M. Tofé-Valera, N

  12. 索拉非尼联合5-氟尿嘧啶对人肝癌细胞株MHCCLM3增殖的抑制作用及其机制%Anti-proliferation effect of sorafenib in combination with 5-FU for hepatocellular carcinoma in vitro: antagonistic performance and mechanism

    Institute of Scientific and Technical Information of China (English)

    邓丽芬; 王艳红; 贾庆安; 任正刚; 沈沪佳; 孙晓静; 李璟寰

    2013-01-01

    Objective To investigate the anti-cancer efficacy and mechanism of sorafenib and 5-fluorouracil (5-FU) therapy in vitro using the HCC cell line MHCCLM3.Methods The effects of somfenib and 5-FU,alone or in combination,on the proliferation of MHCCLM3 cells were evaluated by cell viability assays.Combined-effects analyses were conducted according to the median-effect principle established by Chou and Talalay.Effects on cell cycle distributions were tested by flow cytometry and expression of proteins related to the RAF/MEK/ERK and STAT3 signaling pathways and cyclinD1 were tested by western blotting.Results Sorafenib and 5-FU alone or in combination displayed significant efficacy in inhibiting proliferation of the MHCCLM3 cells,with the following inhibition rates:somfenib:46.16% ± 2.52%,5-FU:28.67% ± 6.16%,and sorafenib + 5-FU:22.59% ± 6.89%.The somfenib + 5-FU combination did not provide better results than treatment with either drag alone.The combination index values of the sorafenib and 5-FU treatments were mainly greater than 1,indicating that the two agents induced antagonistic,instead of synergistic,effects on the MHCCLM3 cells.In addition,the MHCCLM3 cells were less semitive to 5-FU when administrated in combination with sorafenib,as evidenced by the half inhibitory concentration (IC50) significantly increasing from (102.86 ± 27.84) mg/L to (178.61 ± 20.73) mg/L (P =0.003).Sorafenib alone induced G1 phase arrest (increasing from 44.73% ± 1.63% to 65.80% ± 0.56%; P < 0.001) and significantly decreased the proportion of cells in S phase (decreasing from 46.63% ± 0.65% to 22.83% ± 1.75%; P < 0.01),as well as down-regulated cyclinD1 expression (0.57 ± 0.03-fold change vs.untreated control group; P < 0.01).5-FU alone up-regulated cyclinD1 expression (1.45 ± 0.12-fold change vs.untreated control group; P < 0.01).Moreover,somfenib alone significantly inhibited the RAF/MEK/ERK and STAT3 pathways,with the fold-changes of p

  13. Abnormal uterine bleeding in pre-menopausal women.

    Science.gov (United States)

    Singh, Sukhbir; Best, Carolyn; Dunn, Sheila; Leyland, Nicholas; Wolfman, Wendy Lynn; Leyland, Nicholas; Wolfman, Wendy; Allaire, Catherine; Awadalla, Alaa; Best, Carolyn; Dunn, Sheila; Heywood, Mark; Lemyre, Madeleine; Marcoux, Violaine; Menard, Chantal; Potestio, Frank; Rittenberg, David; Singh, Sukhbir

    2013-05-01

    administrés pendant la phase lutéale ne permettent pas une diminution efficace de la perte sanguine; ainsi, ils ne devraient pas être utilisés à titre de traitement visant particulièrement les saignements menstruels abondants. (I-E) 14. Le danazol et les agonistes de la GnRH permettront une diminution efficace des saignements menstruels, et pourraient être utilisés en présence de scénarios dans le cadre desquels l’utilisation d’autres traitements médicaux ou chirurgicaux a échoué ou est contre-indiquée. (I-C) 15. Les patientes qui prennent un agoniste de la GnRH pendant plus de six mois devraient se voir prescrire une hormonothérapie de compensation, lorsque celle-ci n’a pas déjà été mise en œuvre au début du traitement à l’agoniste de la GnRH. (I-A) 16. Le SIU à libération d’un progestatif donne lieu à l’obtention d’issues semblables à celles de l’ablation de l’endomètre chez les femmes qui présentent des saignements menstruels abondants; ainsi, son utilisation pourrait être prise en considération avant d’avoir recours à une intervention chirurgicale. (I-A) 17. Chez des candidates appropriées, les techniques d’ablation non hystéroscopiques devraient être les méthodes d’ablation à privilégier, et ce, en raison de leur efficacité et de leur innocuité supérieures, par comparaison avec les techniques hystéroscopiques. (I-A) 18. À l’exception des AINS, les mêmes agents médicaux qui sont utilisés pour assurer la prise en charge des saignements menstruels abondants chez les femmes présentant une coagulation normale peuvent être efficacement utilisés chez les femmes atteintes de troubles hémostatiques héréditaires. (II-1B) 19. Le recours à une approche multidisciplinaire constitue la meilleure façon d’assurer la prise en charge des femmes atteintes de troubles hémostatiques héréditaires qui connaissent des saignements menstruels considérablement abondants ou chez lesquelles le traitement m

  14. PREFACE: IARD 2010: The 7th Biennial Conference on Classical and Quantum Relativistic Dynamics of Particles and Fields

    Science.gov (United States)

    Horwitz, Lawrence; Hu, Bei-Lok; Lee, Da-Shin; Gill, Tepper; Land, Martin

    2011-12-01

    relativity. The opening session of IARD 2010 was held jointly with the closing seesion of the RQI-N workshop on relativistic quantum information that took place from 28-30 May. This joint meeting emphasized the importance of including dynamical models in relativistic quantum information theory, and of utilizing the perspective of quantum information in extracting results with strong implications for application in relativistic dynamics. Topics discussed at the conference and reported in this volume included investigations into problems in general relativity, relations between quantum field theory, cosmology and, in its statistical aspects, to the extraction of classical attributes of macroscopic quantum systems. There was also a very fundamental study by David R Finkelstein, of the stucture of spacetime itself, posing the possibility that the spacetime manifold emerges from an underlying quantum complex, composed of simplices with spin 1/2 and Fermi statistics, resulting in the regularization of the Standard Model and perhaps a regularized structure for quantum gravity. H T Cho and B L Hu study the vacuum expectation value of the stress energy tensor of a minimally coupled massless scalar field and its role as a source in the Einstein-Langevin equations of quantum gravity, governing the induced metric of fluctuations above the mean field dynamics of the semiclassical theory. C H Chou, B L Hu and Y Subasi study macroscopic quantum phenomena from the point of view of correlations, coupling and criticality, and explain how a macroscopic quantum system may, in this way, acquire classical attributes but still retain some quantum features. S Y Lin discusses a connection with quantum information science as one of the consequences of his work on local projective measurements on relativistic fields. In the field of cosmology, F H Ho and J M Nester study Poincaré gauge theory with a metric compatible connection to an independent dynamics associated with torsion and curvature. They

  15. El HTLV-I y la PET/HAM un modelo de investigación en virología y biología molecular

    Directory of Open Access Journals (Sweden)

    Felipe García Vallejo

    2004-03-01

    :641-648.

    4. CHÁVEZ M, DOMÍNGUEZ M C, BLANK A, QUINTANA M, EIZURU Y, GARCÍA VALLEJO F. Estudio de la reconstrucción de la evolución molecular de la infección actual por el virus linfotrópico humano tipo I en Colombia. Biomédica. 2004; 24: 20-32.

    5. SOTO L, GARCÍA-VALLEJO F, RENJIFO B, DOMÍNGUEZ M, VERGARA A, ESSEX M. Antibodies in gingival crevicular fluid in patients with tropical spastic paraparesis-HTLV- 1-associated myelopathy (TSP/HAM.Viral Immunology 1995; 8 :141-150.

    6. GARCÍA-VALLEJO F, SOTO L, RENJIFO B, CHOU K, DOMÍNGUEZ M C, ESSEX M.1995. Free human T-cell Leukemia virus type I (HTLV-I RNA templates in sera from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy is correlated with increased titers of IgM and IgA. J AIDS and Hum Retrovirol.10:83.

    7. GARCÍA-VALLEJO F, NARVÁEZ M, DOMÍNGUEZ MC, ZANINOVIC V. Anticuerpos para proteínas de astrositos humanos cultivados in vitro circulantes en el suero de individuos seropositivos para el HTLV-I. Rev. Asoc. Col. Cienc. Biol 2002; 14: 82-90.

    8. GARCÍA-VALLEJO F., TRUJILLO R., DOMÍNGUEZ M., ESSEX M. 1996. Molecular mimicry and its implications in the pathogenesis of TSP HTLV-I-Associated myelopathy. In HTLV. Truths and Questions (Ed. V. Zaninovic. Fundación MAR and COLCIENCIAS. pp. 96-104.

    9. RENJIFO B, SOTO L, GARCÍA-VALLEJO F, ESSEX M. Human T cell leukemia virus type I (HTLV-I molecular genotypes and

  16. PREFACE: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials

    Science.gov (United States)

    Sentein, Carole; Schuster, Frédéric; Tardif, François

    2011-07-01

    . Rochester, USA)David PUI (U. Minnesota, USA)Eric QUEMENEUR (CEA, FR)Robert SCHALLER (EPFL, CH)Carole SENTEIN (CEA, FR)Ken TAKEDA (U. Tokyo, JP)Louis TREPIED (MINEFE, FR)Jacques VENDEL (IRSN, FR)Olivier WITSCHGER (INRS, FR) List of Participants AGUY SCordouan, FR ALLEMAN LEcole des Mines de Douai, FR ALPER MUniv. California Berkeley, US ALVES O LUNICAMP, BR AMDAOUD MUniv. Joseph Fourier, FR AMODEO TINERIS, FR AMYOTTE PDalhousie Univ., CA ARAKELIAN M CFundacion Argentina de Nanotecnologia, AR ARZAMASTSEVA ETomsk Polytechnic Univ., RU ASCHBERGER KEuropean Commission-JRC, IT ASHTON AJPCS, GB ASIMAKOPOULOU ACERTH/CPER, GR AUBLANT J-MLNE, FR AUDE-GARCIA CCEA, FR AUFFAN MCEREGE, FR AUGER ACEA, FR BAEK MSeoul Woman's Univ., KR BAEZA AUniv. Paris 7 Diderot, FR BAGUET DCEA, FR BARONE FIstituto Superiore di Sanità, IT BAU SINRS, FR BELLEVILLE PCEA, FR BENAZET SSNPE-Matériaux Energétiques, FR BERGER L-MFraunhofer Institute, DE BERGES MDGUV-IFA, DE BERNARD CNIST, US BERNARD DARKEMA, FR BERNE PCEA, FR BERRET J-FUniv. Paris 7 Diderot, FR BIGORGNE ECNRS, FR BILLAT BPMS, FR BLOCH DCEA, FR BOGDANOVIC-GUILLON AFreelance journalist, FR BOIVIN DRESPIREX France, FR BOLAND SUniv. Paris 7 Diderot, FR BOMBARDIER PFAURE QEI, FR BORASCHI DInstitute of Biomedical Technologies, IT BOTTERO J-YCEREGE, FR BRADLEY JLux Research, US BREGOLI LVeneto Nanotech, IT BRIGNON J-MINERIS, FR BROCHOT CIRSN, FR BROUWER DTNO Quality of Life, NL BUDIMAN TTSE-Systems, DE CABOCHE JEcole des Mines de Douai, FR CALLET GCEA, FR CALOGINE DINERIS, FR CAPONIGRO ALoreal, FR CARRIERE MCEA, FR CASSETTE SThales Research & Technology, FR CHARPENTIER DINERIS, FR CHEN C-CTaiwan Univ., TW CHEN LHealth Canada, CA CHEVALLET MCEA, FR CHOI S-JSeoul Woman's Univ., KR CHOU C-CChung Cheng University, TW CHUNG H-ESeoul Woman's Univ., KR CIMPAN MUniv. Bergen, NO CIOBANU NTU Munich, DE CLARK KInstitute for Work and Health, CH CONJEAUD HUniv. Paris 7 Diderot, FR COSTA PEREIRA CNational Health Institute, PT CROOKS MTSI, GB CUPERTINO DC

  17. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pulmonology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    . Malhotra, K. Tan, G. Woodhead, C.A. Nold-Petry, M.F. NoldABS 40. PRENATAL THERAPY IMPROVES THE SURVIVAL OF PREMATURE INFANTS WITH CONGENITAL CHYLOTHORAX • C.J. Lee, P.N. Tsao, C.Y. Chen, W.S. Hsieh, H.C. ChouABS 41. REFERENCE RANGES OF LAMELLAR BODY COUNTS ON GASTRIC ASPIRATE IN HEALTHY TERM NEWBORNS • S. Arayici, G. Kadioglu Simsek, B. Say, N. Uras, M.Y. Oncel, E. Alyamac Dizdar, U. Buyukkagnici, S. Karahan, F.E. Canpolat, S.S. OguzABS 42. CORD BLOOD PENTRAXIN-3 LEVELS IN RESPIRATORY DISORDERS OF THE NEWBORN • M.O. Arslanoglu, E.C. Dinleyici, N. Tekin, T. Barsan Kaya, O. Aydemir, M.A. AksitABS 43. EVALUATION OF PHYSIOLOGICAL ADAPTATION OF THE LUNG TO POSTNATAL LIFE BY LUNG ULTRASOUND • M. Federici, M.G. Pattumelli, F. Feleppa, C. Gizzi, L. Massenzi, A.M. Giua, S. Sinibaldi, M. Massoud, P.V. FedericiABS 44. NON-INVASIVE MONITORING OF OXYGEN IN THE LUNGS OF NEWBORN INFANTS BY DIODE LASER • M. Larsson, P. Lundin, E. Krite Svanberg, J. Åkeson, K. Svanberg, S. Svanberg, S. Andersson-Engels, V. FellmanABS 45. CELLULAR AGING, MEASURED AS TELOMERE ATTRITION RATE, IS NOT ACCELERATED IN PRETERM INFANTS DURING THE FIRST 18 MONTHS OF LIFE • E. Henckel, Z. Haider, P. Kosma, C. Palme-Kilander, G. Roos, S. Degerman, K. BohlinABS 46. INHALED NITRIC OXIDE DECREASES MORTALITY IN INFANTS LESS THAN 28 WEEKS GESTATION FOLLOWING PRETERM PRELABOUR RUPTURE OF MEMBRANES • S. Pal, G.J. Belteki, G. Vass, T. Ibrahim, P. Clarke, Z. Molnar, Y. Singh, A.E. CurleyABS 47. PLASMA PRO-ENDOTHELIN-1 AND PRO-ATRIAL NATRIURETIC PEPTIDE AS EARLY BIOMARKERS FOR DEVELOPMENT OF BRONCHOPULMONARY DYSPLASIA IN VERY PRETERM INFANTS • R. Gerull, R. Neumann, M. Nelle, S. Schulzke, S. WellmannABS 48. TIMELY IN-HOSPITAL VACCINATION OF VLBW INFANTS REDUCES THE RATE OF BRONCHITIS AFTER DISCHARGE OF VLBW INFANTS • G. Stichtenoth, C. Härtel, E. Herting, W. Göpel; German Neonatal Network (GNNABS 49. A MURINE MODEL OF BRONCHOPULMONARY DYSPLASIA – PRELIMINARY RESULTS FROM WHOLE-GENOME mRNA EXPRESSION STUDY

  18. Prioritizing social and economic effects of sport places on Urban Environment (A case study: Yazd City

    Directory of Open Access Journals (Sweden)

    M. Soltanhosseini

    2013-01-01

    Sciences”, Samt Press, Tehran.Lai. W H, Chang P L, Chou. Y C (2010, “Fuzzy MCDM Approach to R&D Project Evaluation in Taiwan’s Public Sectors”, Journal of Technology Management in China, Vol. 5, No. 1, pp. 84-101. Macintyre. S, Ellaway. A, (1998, “Social and local variations in the use of urban neighborhoods: a case study in Glasgow”, Health & Place, Vol. 4, Issue. 1, pp. 91–94.Madrigal. R (2001, “Social Identity Effects in a Belief- Attitude-Intentions Hierarchy: Implications for Corporate Sponsorship”, Psychology and Marketing, Vol. 18, Issue. 2, pp. 145-165.Mohharamzade. M (2007, “Sport Organization Management”, 2nd Ed, University of Urmia.Momeni. M (2010, “New discussions in operation in research”, 1st Ed, University of Tehran. Opricovic. S& Tzeng. G H (2004, “Compromise Solution by MCDM Methods: A Comparative Analysis of VIKOR and TOPSIS”, European Journal of Operational Research, 156, pp. 445–455.Pascual. C, Regidor. E, Martinez. D, ElisaCalle. M, Dominguez. V (2009, “Socioeconomic environment, availability of sports facilities, and jogging, swimming and gym use”, Health & Place, Vol. 15, Issue 2, pp. 553–561.Pascual. C, Regidor. E, Astasio. P, Ortega. P, Navarro. P, Dominguez. V (2007, “The association of current and sustained area-based adverse socioeconomic environment with physical inactivity”, Social Science and Medicine, Vol. 65, Issue. 3, pp. 454–466.Physical Education organization (1995, “Technical Tenet of Iran’s Stadium (Study of Today Status”, Section 1, 1st Ed.Rosentraub. M S (2006, “The Local Context of a Sports Strategy for Economic Development”, Economic Development Quarterly, Vol. 20, Issue. 3, pp. 278-291.Sanderson. K, Harris. F, Russel. S (2000, “The economic Benefit of Sport: A Review”, Hong Kong sport development board, Business and Economic Research Ltd (Wellington, N.Z.Santo. CH A (2005, “The Economic Impact of Sports Stadiums: Recasting the Analysis in Context”, journal of urban