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Sample records for hui qwb sf-6d

  1. Unchained Melody: Revisiting the Estimation of SF-6D Values

    Science.gov (United States)

    Craig, Benjamin M.

    2015-01-01

    Purpose In the original SF-6D valuation study, the analytical design inherited conventions that detrimentally affected its ability to predict values on a quality-adjusted life year (QALY) scale. Our objective is to estimate UK values for SF-6D states using the original data and multi-attribute utility (MAU) regression after addressing its limitations and to compare the revised SF-6D and EQ-5D value predictions. Methods Using the unaltered data (611 respondents, 3503 SG responses), the parameters of the original MAU model were re-estimated under 3 alternative error specifications, known as the instant, episodic, and angular random utility models. Value predictions on a QALY scale were compared to EQ-5D3L predictions using the 1996 Health Survey for England. Results Contrary to the original results, the revised SF-6D value predictions range below 0 QALYs (i.e., worse than death) and agree largely with EQ-5D predictions after adjusting for scale. Although a QALY is defined as a year in optimal health, the SF-6D sets a higher standard for optimal health than the EQ-5D-3L; therefore, it has larger units on a QALY scale by construction (20.9% more). Conclusions Much of the debate in health valuation has focused on differences between preference elicitation tasks, sampling, and instruments. After correcting errant econometric practices and adjusting for differences in QALY scale between the EQ-5D and SF-6D values, the revised predictions demonstrate convergent validity, making them more suitable for UK economic evaluations compared to original estimates. PMID:26359242

  2. Validation of the SF-6D Health State Utilities Measure in Lower Extremity Sarcoma

    Directory of Open Access Journals (Sweden)

    Kenneth R. Gundle

    2014-01-01

    Full Text Available Aim. Health state utilities measures are preference-weighted patient-reported outcome (PRO instruments that facilitate comparative effectiveness research. One such measure, the SF-6D, is generated from the Short Form 36 (SF-36. This report describes a psychometric evaluation of the SF-6D in a cross-sectional population of lower extremity sarcoma patients. Methods. Patients with lower extremity sarcoma from a prospective database who had completed the SF-36 and Toronto Extremity Salvage Score (TESS were eligible for inclusion. Computed SF-6D health states were given preference weights based on a prior valuation. The primary outcome was correlation between the SF-6D and TESS. Results. In 63 pairs of surveys in a lower extremity sarcoma population, the mean preference-weighted SF-6D score was 0.59 (95% CI 0.4–0.81. The distribution of SF-6D scores approximated a normal curve (skewness = 0.11. There was a positive correlation between the SF-6D and TESS (r=0.75, P<0.01. Respondents who reported walking aid use had lower SF-6D scores (0.53 versus 0.61, P=0.03. Five respondents underwent amputation, with lower SF-6D scores that approached significance (0.48 versus 0.6, P=0.06. Conclusions. The SF-6D health state utilities measure demonstrated convergent validity without evidence of ceiling or floor effects. The SF-6D is a health state utilities measure suitable for further research in sarcoma patients.

  3. Construct validity of SF-6D health state utility values in an employed population.

    Science.gov (United States)

    Baxter, Siyan; Sanderson, Kristy; Venn, Alison; Otahal, Petr; Palmer, Andrew J

    2015-04-01

    Health utility values permit cost utility analysis in workplace health promotion; however, utility measures of working populations have not been validated. To investigate construct validity of SF-6D health utility in a public service workforce. SF-12v2 Health Survey was administered to 3,408 randomly selected public service employees in Australia in 2010. SF-12 scores were converted to SF-6D health utility values. Associations and correlates of SF-6D with health, socio-demographic and work characteristics [comorbidities, body mass index (BMI), Kessler-10 psychological distress (K10), education, salary, effort-reward imbalance (ERI), absenteeism] were explored. Ceiling effects were analysed. Nationally representative employee SF-6D values from the Household, Income and Labour Dynamics in Australia (HILDA) survey (n = 11,234) were compared. All analyses were stratified by sex. Mean (SE) age was 45.7 (0.35) males; 44.5 (0.22) females. Females represented 72 % of the sample. Mean (SE) health utility 0.792 (0.004); 0.771 (0.003) was higher in males. SF-6D demonstrated both a significant inverse association (p negative correlations (female; male) with K10 (r = -0.63; r = -0.66), comorbidity count (r = -0.40; r = -0.33), ERI (r = -0.37; r = -0.34) and absenteeism (p imbalance and absenteeism are negatively associated with employee health. SF-6D is a valid measure of perceived health states in working populations.

  4. Estimating health state utility values for comorbid health conditions using SF-6D data.

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    Ara, Roberta; Brazier, John

    2011-01-01

    When health state utility values for comorbid health conditions are not available, data from cohorts with single conditions are used to estimate scores. The methods used can produce very different results and there is currently no consensus on which is the most appropriate approach. The objective of the current study was to compare the accuracy of five different methods within the same dataset. Data collected during five Welsh Health Surveys were subgrouped by health status. Mean short-form 6 dimension (SF-6D) scores for cohorts with a specific health condition were used to estimate mean SF-6D scores for cohorts with comorbid conditions using the additive, multiplicative, and minimum methods, the adjusted decrement estimator (ADE), and a linear regression model. The mean SF-6D for subgroups with comorbid health conditions ranged from 0.4648 to 0.6068. The linear model produced the most accurate scores for the comorbid health conditions with 88% of values accurate to within the minimum important difference for the SF-6D. The additive and minimum methods underestimated or overestimated the actual SF-6D scores respectively. The multiplicative and ADE methods both underestimated the majority of scores. However, both methods performed better when estimating scores smaller than 0.50. Although the range in actual health state utility values (HSUVs) was relatively small, our data covered the lower end of the index and the majority of previous research has involved actual HSUVs at the upper end of possible ranges. Although the linear model gave the most accurate results in our data, additional research is required to validate our findings. Copyright © 2011 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  5. Predicting SF-6D utility scores from the Oswestry disability index and numeric rating scales for back and leg pain.

    Science.gov (United States)

    Carreon, Leah Y; Glassman, Steven D; McDonough, Christine M; Rampersaud, Raja; Berven, Sigurd; Shainline, Michael

    2009-09-01

    Cross-sectional cohort. The purpose of this study is to provide a model to allow estimation of utility from the Short Form (SF)-6D using data from the Oswestry Disability Index (ODI), Back Pain Numeric Rating Scale (BPNRS), and the Leg Pain Numeric Rating Scale (LPNRS). Cost-utility analysis provides important information about the relative value of interventions and requires a measure of utility not often available from clinical trial data. The ODI and numeric rating scales for back (BPNRS) and leg pain (LPNRS), are widely used disease-specific measures for health-related quality of life in patients with lumbar degenerative disorders. The purpose of this study is to provide a model to allow estimation of utility from the SF-6D using data from the ODI, BPNRS, and the LPNRS. SF-36, ODI, BPNRS, and LPNRS were prospectively collected before surgery, at 12 and 24 months after surgery in 2640 patients undergoing lumbar fusion for degenerative disorders. Spearman correlation coefficients for paired observations from multiple time points between ODI, BPNRS, and LPNRS, and SF-6D utility scores were determined. Regression modeling was done to compute the SF-6D score from the ODI, BPNRS, and LPNRS. Using a separate, independent dataset of 2174 patients in which actual SF-6D and ODI scores were available, the SF-6D was estimated for each subject and compared to their actual SF-6D. In the development sample, the mean age was 52.5 +/- 15 years and 34% were male. In the validation sample, the mean age was 52.9 +/- 14.2 years and 44% were male. Correlations between the SF-6D and the ODI, BPNRS, and LPNRS were statistically significant (P < 0.0001) with correlation coefficients of 0.82, 0.78, and 0.72, respectively. The regression equation using ODI, BPNRS,and LPNRS to predict SF-6D had an R of 0.69 and a root mean square error of 0.076. The model using ODI alone had an R of 0.67 and a root mean square error of 0.078. The correlation coefficient between the observed and estimated

  6. Complications among colorectal cancer survivors: SF-6D preference-weighted quality of life scores.

    Science.gov (United States)

    Hornbrook, Mark C; Wendel, Christopher S; Coons, Stephen Joel; Grant, Marcia; Herrinton, Lisa J; Mohler, M Jane; Baldwin, Carol M; McMullen, Carmit K; Green, Sylvan B; Altschuler, Andrea; Rawl, Susan M; Krouse, Robert S

    2011-03-01

    Societal preference-weighted health-related quality of life (HRQOL) scores enable comparing multidimensional health states across diseases and treatments for research and policy. To assess the effects of living with a permanent intestinal stoma, compared with a major bowel resection, among colorectal cancer (CRC) survivors. Cross-sectional multivariate linear regression analysis to explain preference-weighted HRQOL scores. In all, 640 CRC survivors (≥ 5 years) from 3 group model health maintenance organizations; ostomates and nonostomates with colorectal resections for CRC were matched on gender, age (± 5 years), time since diagnosis, and tumor site (rectum vs. colon). SF-6D scoring system was applied to Medical Outcomes Study Short Form-36 version 2 (SF-36v2); City of Hope Quality of Life-Ostomy; and Charlson-Deyo comorbidity index. Survey of CRC survivors linked to respondents' clinical data extracted from health maintenance organization files. Response rate was 52%. Ostomates and nonostomates had similar sociodemographic characteristics. Mean SF-6D score was 0.69 for ostomates, compared with 0.73 for nonostomates (P ostomy after other factors were taken into account. Surgical complications, comorbidities, and metastatic disease lowered the preference-weighted HRQOL of CRC survivors with and without ostomies. Further research to understand and reduce late complications from CRC surgeries as well as associated depression is warranted.

  7. Understanding the relationship between the EQ-5D, SF-6D, HAQ and disease activity in inflammatory arthritis.

    LENUS (Irish Health Repository)

    Adams, Roisin

    2012-02-01

    BACKGROUND: The growth of economic analyses and in particular cost-utility analyses (CUA), which use the QALY as a measure of outcome, has heightened the interest in the methodologies used to calculate the QALY. The EQ-5D has produced quite different utility values from that of the SF-6D. This article seeks to understand these differences using a cohort of patients with inflammatory arthritis. OBJECTIVE: To examine the relationship between the disease-specific measure, Health Assessment Questionnaire (HAQ) disability index (DI) and the preference-based measures, SF-6D, EQ-5D and European League Against Arthritis (EULAR) Disease Activity Score (DAS) in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS: Patients with RA and PsA (n = 504) attending a tertiary rheumatology referral centre completed the HAQ, SF-6D and the EQ-5D before starting biological therapy and again 12 months later. The SF-36 was converted into a utility using the preference-based SF-6D. Clinical outcomes such as the DAS, joint counts and laboratory measures were also recorded. We calculated single index utility scores from the preference-based instruments using UK population norms. We used regression analysis to derive a mapping function and calculated utility scores from the HAQDI and the DAS 28. RESULTS: The mean utility observed at baseline for RA was 0.43 for the EQ-5D and 0.54 for the SF-6D and for PsA was 0.49 for the EQ-5D and 0.57 for the SF-6D. The utility gain demonstrated by the EQ-5D was over twice that of the SF-6D. The EQ-5D scored 17% of the RA group as less than 0 (state defined as worse than death); 7% of this group remained less than 0 at follow-up. The distribution of the utility estimates was similar for both RA and PsA. CONCLUSIONS: Our findings draw attention to the impact of states worse than death on the overall distribution for the EQ-5D derived utilities and how these impact on its use in practice. EQ-5D-derived QALY changes are over twice

  8. The relationship between SF-6D utility scores and lifestyle factors across three life stages: evidence from the Australian Longitudinal Study on Women's Health.

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    Kanesarajah, Jeeva; Waller, Michael; Whitty, Jennifer A; Mishra, Gita D

    2017-06-01

    To investigate how SF-6D utility scores change with age between generations of women and to quantify the relationship of SF-6D with lifestyle factors across life stages. Up to seven waves of self-reported, longitudinal data were drawn for the 1973-1978 (young, N = 13772), 1946-1951 (mid-age, N = 12792), 1921-1926 (older, N = 9972) cohorts from the Australian Longitudinal Study on Women's Health. Mixed effects models were employed for analysis. Young and mid-age women had similar average SF-6D scores at baseline (0.63-0.64), which remained consistent over the 16-year period. However, older women had lower scores at baseline at 0.57 which steadily declined over 15 years. Across cohorts, low education attainment, greater difficulty in managing income, obesity, physical inactivity, heavy smoking, no alcohol consumption, and increasing stress levels were associated with lower SF-6D scores. The magnitude of effect varied between cohorts. SF-6D scores were lower amongst young women with high-risk drinking behaviours than low-risk drinkers. Mid-age women, who were underweight, never married, or underwent surgical menopause also reported lower SF-6D scores. Older women who lived in remote areas, who were ex-smokers, or were underweight, reported lower SF-6D scores. The SF-6D utility score is sensitive to differences in lifestyle factors across adult life stages. Gradual loss of physical functioning may explain the steady decline in health for older women. Key factors associated with SF-6D include physical activity, body mass index, menopause status, smoking, alcohol use, and stress. Factors associated with poorer SF-6D scores vary in type and magnitude at different life stages.

  9. HUI2 and HUI3

    African Journals Online (AJOL)

    Keywords: Health utility index, HUI2, HUI3, Quality of life, Diabetes. Tropical ... in the form of Quality Adjusted Life Years. (QALYs) [5]. ... HUI3 specifically assesses happiness versus depression. .... medication, longer duration of diabetes and.

  10. Determining Health-Related Quality-of-Life Outcomes Using the SF-6D Following Total Hip Arthroplasty.

    Science.gov (United States)

    Elmallah, Randa K; Chughtai, Morad; Adib, Farshad; Bozic, Kevin J; Kurtz, Steven M; Mont, Michael A

    2017-03-15

    Following total hip arthroplasty, patients' perception of their postoperative improvement and health plays a large role in satisfaction with and success of the surgical procedure. The Short Form-6D (SF-6D) is a health-related quality-of-life measure that assigns numerical value to the perception of patients' own health. The purpose was to determine SF-6D values of patients after total hip arthroplasty, to determine whether score changes were clinically relevant, and to compare these with postoperative functional improvements. We evaluated 188 patients who underwent primary total hip arthroplasty at 7 institutions and who had a mean age of 69 years (range, 47 to 88 years) and a mean body mass index of 28.8 kg/m (range, 19.8 to 38.9 kg/m). The SF-6D values were obtained from patients' SF-36 scores, and clinical relevance of value changes was determined using effect size. Using previous research, effect sizes were considered small between 0.2 and 0.5, moderate between 0.6 to 0.8, and large at >0.8. Clinical correlation was assessed using the Lower-Extremity Activity Scale and Harris hip scores. Patients were assessed preoperatively and postoperatively at 6 months and 1, 2, 3, and 5 years. The SF-6D scores improved from preoperatively and achieved significance (p < 0.05) at all points. The effect size demonstrated good clinical relevance up to the latest follow-up: 1.27 at 6 months, 1.30 at 1 year, 1.07 at 2 years, 1.08 at 3 years, and 1.05 at 5 years. The Lower-Extremity Activity Scale improved at all follow-up points from preoperatively to 1.8 at 6 months, 2.0 at 1 year, 1.8 at 2 years, 1.5 at 3 years, and 1.6 points at 5 years. The Harris hip score improved to 38 points at 6 months, 40 points at 1 year, 38 points at 2 years, 39 points at 3 years, and 41 points at 5 years postoperatively. The improvements in the Lower-Extremity Activity Scale and the Harris hip score significantly positively correlated (p < 0.01) with the SF-6D scores at all time points. SF-6D scores

  11. A Head-to-Head Comparison of UK SF-6D and Thai and UK EQ-5D-5L Value Sets in Thai Patients with Chronic Diseases.

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    Sakthong, Phantipa; Munpan, Wipaporn

    2017-10-01

    Little was known about the head-to-head comparison of psychometric properties between SF-6D and EQ-5D-5L or the different value sets of EQ-5D-5L. Therefore, this study set out to compare the psychometric properties including agreement, convergent, and known-group validity between the SF-6D and the EQ-5D-5L using the real value sets from Thailand and the UK in patients with chronic diseases. 356 adults taking a medication for at least 3 months were identified from a university hospital in Bangkok, Thailand, between July 2014 and March 2015. Agreement was assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots. Convergent validity was evaluated using Spearman's rank correlation coefficients between SF-6D and EQ-5D-5L and EQ-VAS and SF-12v2. For known-groups validity, the Mann-Whitney U test and Kruskal-Wallis test were used to examine the associations between SF-6D and EQ-5D-5L and patient characteristics. Agreements between the SF-6D and the EQ-5D-5L using Thai and UK value sets were fair, with ICCs of 0.45 and 0.49, respectively. Bland-Altman plots showed that the majority of the SF-6D index scores were lower than the EQ-5D-5L index scores. Both the EQ-5D-5L value sets were more related to the EQ-VAS and physical health, while the SF-6D was more associated with mental health. Both EQ-5D-5L value sets were more sensitive than the SF-6D in discriminating patients with different levels of more known groups except for adverse drug reactions. The SF-6D and both EQ-5D-5L value sets appeared to be valid but sensitive to different outcomes in Thai patients with chronic diseases.

  12. Validation and comparison of EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) among stable angina patients

    OpenAIRE

    Wu, Jing; Han, Yuerong; Zhao, Fei-Li; Zhou, Jin; Chen, Zhijun; Sun, He

    2014-01-01

    Objectives Several preference-based health-related quality of life (HRQoL) instruments have been published and widely used in different populations. However no consensus has emerged regarding the most appropriate instrument in therapeutic area of stable angina. This study compared and validated the psychometric properties of two generic preference-based instruments, the EQ-5D and SF-6D, among Chinese stable angina patients. Methods Convergent validity of the EQ-5D and SF-6D was examined with ...

  13. Validation and comparison of EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) among stable angina patients.

    Science.gov (United States)

    Wu, Jing; Han, Yuerong; Zhao, Fei-Li; Zhou, Jin; Chen, Zhijun; Sun, He

    2014-10-25

    Several preference-based health-related quality of life (HRQoL) instruments have been published and widely used in different populations. However no consensus has emerged regarding the most appropriate instrument in therapeutic area of stable angina. This study compared and validated the psychometric properties of two generic preference-based instruments, the EQ-5D and SF-6D, among Chinese stable angina patients. Convergent validity of the EQ-5D and SF-6D was examined with eight a priori hypotheses from stable angina patients in conjunction with Seattle Angina Questionnaire (SAQ). Responsiveness was compared using the effect size (ES), relative efficiency (RE) and receiver operating characteristic (ROC) curves. Agreement between the EQ-5D and SF-6D was tested using intra-class correlation coefficient (ICC) and Bland-Altman plot. Factors affecting utility difference were explored with multiple linear regression analysis. In 411 patients (mean age 68.08 ± 11.35), mean utility scores (SD) were 0.78 (0.15) for the EQ-5D and 0.68 (0.12) for the SF-6D. Validity was demonstrated by the moderate to strong correlation coefficients (Range: 0.368-0.594, Pstable-angina-specific health status than the EQ-5D (ES: 0.426 to 1.126). RE suggested that the SF-6D (RE: 44.8 to 177.8%) was more efficient than the EQ-5D except for physical function. Poor agreement between them was observed with ICC (0.448, Pstable angina patients. The SF-6D may be a more effective tool with lower ceiling effect and greater sensitivity. Further study is needed to compare other properties, such as reliability and longitudinal response.

  14. Comparison of the SF6D, the EQ5D, and the oswestry disability index in patients with chronic low back pain and degenerative disc disease.

    Science.gov (United States)

    Johnsen, Lars G; Hellum, Christian; Nygaard, Oystein P; Storheim, Kjersti; Brox, Jens I; Rossvoll, Ivar; Leivseth, Gunnar; Grotle, Margreth

    2013-04-26

    The need for cost effectiveness analyses in randomized controlled trials that compare treatment options is increasing. The selection of the optimal utility measure is important, and a central question is whether the two most commonly used indexes - the EuroQuol 5D (EQ5D) and the Short Form 6D (SF6D) - can be used interchangeably. The aim of the present study was to compare change scores of the EQ5D and SF6D utility indexes in terms of some important measurement properties. The psychometric properties of the two utility indexes were compared to a disease-specific instrument, the Oswestry Disability Index (ODI), in the setting of a randomized controlled trial for degenerative disc disease. In a randomized controlled multicentre trial, 172 patients who had experienced low back pain for an average of 6 years were randomized to either treatment with an intensive back rehabilitation program or surgery to insert disc prostheses. Patients filled out the ODI, EQ5D, and SF-36 at baseline and two-year follow up. The utility indexes was compared with respect to measurement error, structural validity, criterion validity, responsiveness, and interpretability according to the COSMIN taxonomy. At follow up, 113 patients had change score values for all three instruments. The SF6D had better similarity with the disease-specific instrument (ODI) regarding sensitivity, specificity, and responsiveness. Measurement error was lower for the SF6D (0.056) compared to the EQ5D (0.155). The minimal important change score value was 0.031 for SF6D and 0.173 for EQ5D. The minimal detectable change score value at a 95% confidence level were 0.157 for SF6D and 0.429 for EQ5D, and the difference in mean change score values (SD) between them was 0.23 (0.29) and so exceeded the clinical significant change score value for both instruments. Analysis of psychometric properties indicated that the indexes are unidimensional when considered separately, but that they do not exactly measure the same

  15. Hui Wei | NREL

    Science.gov (United States)

    Hui Wei Photo of Hui Wei Hui Wei Researcher IV-Molecular Biology Hui.Wei@nrel.gov | 303-384-6620 consortia system. Additional Publications "In Situ Micro-Spectroscopic Investigation of Lignin in Molecular Biology (2012) "Tracking Dynamics of Biomass Composting by Monitoring the Changes in

  16. Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis.

    Science.gov (United States)

    Huppertz-Hauss, Gert; Aas, Eline; Lie Høivik, Marte; Langholz, Ebbe; Odes, Selwyn; Småstuen, Milada; Stockbrugger, Reinhold; Hoff, Geir; Moum, Bjørn; Bernklev, Tomm

    2016-01-01

    Background. The treatment of chronic inflammatory bowel disease (IBD) is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D) and the Euro QoL (EQ-5D), two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis. Clinical and demographic data were assessed, and the Short Form 36 (SF-36) was employed. Utility scores were obtained by calculating the SF-6D index values from the SF-36 data for comparison with the scores obtained with the EQ-5D questionnaire. Results. The SF-6D and EQ-5D provided good sensitivities for detecting disease activity-dependent utility differences. However, the single-measure intraclass correlation coefficient was 0.58, and the Bland-Altman plot indicated numerous values beyond the limits of agreement. Conclusions. There was poor agreement between the measures retrieved from the EQ-5D and the SF-6D utility instruments. Although both instruments may provide good sensitivity for the detection of disease activity-dependent utility differences, the instruments cannot be used interchangeably. Cost-utility analyses performed with only one utility instrument must be interpreted with caution.

  17. Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis

    Directory of Open Access Journals (Sweden)

    Gert Huppertz-Hauss

    2016-01-01

    Full Text Available Background. The treatment of chronic inflammatory bowel disease (IBD is costly, and limited resources call for analyses of the cost effectiveness of therapeutic interventions. The present study evaluated the equivalency of the Short Form 6D (SF-6D and the Euro QoL (EQ-5D, two preference-based HRQoL instruments that are broadly used in cost-effectiveness analyses, in an unselected IBD patient population. Methods. IBD patients from seven European countries were invited to a follow-up visit ten years after their initial diagnosis. Clinical and demographic data were assessed, and the Short Form 36 (SF-36 was employed. Utility scores were obtained by calculating the SF-6D index values from the SF-36 data for comparison with the scores obtained with the EQ-5D questionnaire. Results. The SF-6D and EQ-5D provided good sensitivities for detecting disease activity-dependent utility differences. However, the single-measure intraclass correlation coefficient was 0.58, and the Bland-Altman plot indicated numerous values beyond the limits of agreement. Conclusions. There was poor agreement between the measures retrieved from the EQ-5D and the SF-6D utility instruments. Although both instruments may provide good sensitivity for the detection of disease activity-dependent utility differences, the instruments cannot be used interchangeably. Cost-utility analyses performed with only one utility instrument must be interpreted with caution.

  18. A comparison of the sensitivity of EQ-5D, SF-6D and TTO utility values to changes in vision and perceived visual function in patients with primary open-angle glaucoma

    Directory of Open Access Journals (Sweden)

    Bozzani Fiammetta Maria

    2012-08-01

    Full Text Available Abstract Background Economic viability of treatments for primary open-angle glaucoma (POAG should be assessed objectively to prioritise health care interventions. This study aims to identify the methods for eliciting utility values (UVs most sensitive to differences in visual field and visual functioning in patients with POAG. As a secondary objective, the dimensions of generic health-related and vision-related quality of life most affected by progressive vision loss will be identified. Methods A total of 132 POAG patients were recruited. Three sets of utility values (EuroQoL EQ-5D, Short Form SF-6D, Time Trade Off and a measure of perceived visual functioning from the National Eye Institute Visual Function Questionnaire (VFQ-25 were elicited during face-to-face interviews. The sensitivity of UVs to differences in the binocular visual field, visual acuity and visual functioning measures was analysed using non-parametric statistical methods. Results Median utilities were similar across Integrated Visual Field score quartiles for EQ-5D (P = 0.08 whereas SF-6D and Time-Trade-Off UVs significantly decreased (p = 0.01 and p = 0.001, respectively. The VFQ-25 score varied across Integrated Visual Field and binocular visual acuity groups and was associated with all three UVs (P ≤ 0.001; most of its vision-specific sub-scales were associated with the vision markers. The most affected dimension was driving. A relationship with vision markers was found for the physical component of SF-36 and not for any dimension of EQ-5D. Conclusions The Time-Trade-Off was more sensitive than EQ-5D and SF-6D to changes in vision and visual functioning associated with glaucoma progression but could not measure quality of life changes in the mildest disease stages.

  19. Five preference-based indexes in cataract and heart failure patients were not equally responsive to change.

    Science.gov (United States)

    Kaplan, Robert M; Tally, Steven; Hays, Ron D; Feeny, David; Ganiats, Theodore G; Palta, Mari; Fryback, Dennis G

    2011-05-01

    To compare the responsiveness to clinical change of five widely used preference-based health-related quality-of-life indexes in two longitudinal cohorts. Five generic instruments were simultaneously administered to 376 adults undergoing cataract surgery and 160 adults in heart failure management programs. Patients were assessed at baseline and reevaluated after 1 and 6 months. The measures were the Short Form (SF)-6D (based on responses scored from SF-36v2), Self-Administered Quality of Well-being Scale (QWB-SA), the EuroQol-5D developed by the EuroQol Group, the Health Utilities Indexes Mark 2 (HUI2) and Mark 3 (HUI3). Cataract patients completed the National Eye Institute Visual Functioning Questionnaire-25, and heart failure patients completed the Minnesota Living with Heart Failure Questionnaire. Responsiveness was estimated by the standardized response mean. For cataract patients, mean changes between baseline and 1-month follow-up for the generic indices ranged from 0.00 (SF-6D) to 0.052 (HUI3) and were statistically significant for all indexes except the SF-6D. For heart failure patients, only the SF-6D showed significant change from baseline to 1 month, whereas only the QWB-SA change was significant between 1 and 6 months. Preference-based methods for measuring health outcomes are not equally responsive to change. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. [Summary of Hui prescriptions for treating cough].

    Science.gov (United States)

    Zhang, Wen-jin; Liu, Yue; Zhang, Xin-hui

    2015-02-01

    In this study, by using the method of literature research, 35 prescriptions related to asthma therapy has been screened out from Hui medicine through collecting the ancient and modern literature. A comparison of fragrant medicine between the name in Arab and Chinese herbal medicine is done. The countif function in Microsoft Excel 2007 is used to get the prescriptions of the drug on the frequency statistics, summarizing the common drugs of Hui medicine for asthma are Pinellia, almond, white sugar, walnut. According to the commonly used drugs, the pathogeny and treatment principle about Hui medicine for asthma is preliminarily inferred combining literature research and the related Hui medical theory. In this study, those prescriptions have been classified into 21 cases which are effective and can be used in medical therapy according to the relevant literatures with the development of the Hui people in their long process of formation of the unique diet culture, 14 useful and convenient Halal diet therapies are made up according to the indications, therapies, party name and composition. Halal diet and "medicine and food" herbs are preliminarily analyzed and summarized, which can be convenient for the people to reduce pains through the diet and improve health awareness.

  1. Standard error of measurement of 5 health utility indexes across the range of health for use in estimating reliability and responsiveness.

    Science.gov (United States)

    Palta, Mari; Chen, Han-Yang; Kaplan, Robert M; Feeny, David; Cherepanov, Dasha; Fryback, Dennis G

    2011-01-01

    Standard errors of measurement (SEMs) of health-related quality of life (HRQoL) indexes are not well characterized. SEM is needed to estimate responsiveness statistics, and is a component of reliability. To estimate the SEM of 5 HRQoL indexes. The National Health Measurement Study (NHMS) was a population-based survey. The Clinical Outcomes and Measurement of Health Study (COMHS) provided repeated measures. A total of 3844 randomly selected adults from the noninstitutionalized population aged 35 to 89 y in the contiguous United States and 265 cataract patients. The SF6-36v2™, QWB-SA, EQ-5D, HUI2, and HUI3 were included. An item-response theory approach captured joint variation in indexes into a composite construct of health (theta). The authors estimated 1) the test-retest standard deviation (SEM-TR) from COMHS, 2) the structural standard deviation (SEM-S) around theta from NHMS, and 3) reliability coefficients. SEM-TR was 0.068 (SF-6D), 0.087 (QWB-SA), 0.093 (EQ-5D), 0.100 (HUI2), and 0.134 (HUI3), whereas SEM-S was 0.071, 0.094, 0.084, 0.074, and 0.117, respectively. These yield reliability coefficients 0.66 (COMHS) and 0.71 (NHMS) for SF-6D, 0.59 and 0.64 for QWB-SA, 0.61 and 0.70 for EQ-5D, 0.64 and 0.80 for HUI2, and 0.75 and 0.77 for HUI3, respectively. The SEM varied across levels of health, especially for HUI2, HUI3, and EQ-5D, and was influenced by ceiling effects. Limitations. Repeated measures were 5 mo apart, and estimated theta contained measurement error. The 2 types of SEM are similar and substantial for all the indexes and vary across health.

  2. Gebruik van elektriciteit: Domotica: Huis van de toekomst: Klas 4 vwo (docentversie)

    NARCIS (Netherlands)

    van Buuren, O.; van der Lee, M.

    2009-01-01

    Deze module behandelt elektriciteit en automatisering in huis. We richten ons daarbij ook op het huis van de toekomst. Bij de elektriciteitsleer ligt de nadruk op het gebruik van elektriciteit in huis, bij de automatisering op intelligente systemen in huis.

  3. Gebruik van elektriciteit: Domotica: Huis van de toekomst: Klas 4 havo

    NARCIS (Netherlands)

    van Buuren, O.; van der Lee, M.

    2008-01-01

    Deze module behandelt elektriciteit en automatisering in huis. We richten ons daarbij ook op het huis van de toekomst. Bij de elektriciteitsleer ligt de nadruk op het gebruik van elektriciteit in huis, bij de automatisering op intelligente systemen in huis. Er komt een vervolg module domotica 2 als

  4. [Decipherment and annotation of some terms in the remnant scrolls of Hui hui yao fang (Huihui Formularies)].

    Science.gov (United States)

    Huang, Y; Wang, J

    2017-05-28

    The etymology of the terms in Hui hui yao fang ( Huihui Formularies ) is complicated. Their origin might be Arabian, Persian, or Sanskrit, or even the northern dialects of Han language during the Yuan and Ming Dynasties. There are obvious mistakes or indefinite decipherments and interpretations of the terms in Song Xian's Investigated Annotations of Huihui Formularies . There are also missing annotations for those transliterated terms. To tackle such defects, 12 such terms are deciphered and annotated here.

  5. La recherche alpine aujourd’hui

    Directory of Open Access Journals (Sweden)

    Jean-Jacques Brun

    2009-06-01

    Full Text Available Alpine research benefits from several international coordination networks, only one of which – ISCAR (the International Scientific Committee on Research in the Alps – works solely in the Alpine arc. The creation of ISCAR is a consequence of the input and involvement of various Alpine partners around the Alpine Convention. Alpine research now aims to promote an integrated vision of Alpine territories focusing on creating and maintaining spatial and temporal networks of sustainable relationships between humans and the other components of the ecosphere. It combines resource usage with conservation of the biological and cultural diversity that makes up the Alpine identity. This article aims to show: (1 how international Alpine research coordination is organised; (2 the role played by the Alpine Convention as a framework of reference for specifically Alpine research; and (3 the role that the ISCAR international commit-tee and the Interreg “Alpine Space” programmes play in uniting research around territorial challenges relating to biodiversity conservation and territorial development.La recherche sur les Alpes bénéficie de plusieurs réseaux de coordination internationaux dont un seul, le comité international recherche alpine (ISCAR, se consacre exclusivement à l’arc alpin. La création de l’ISCAR est une retombée de la mobilisation des divers partenaires alpins autour de la mise en place de la Convention alpine. Aujourd’hui, la recherche alpine vise à promouvoir une vision intégrée des territoires centrée sur la création et le maintien d’un réseau spatial et temporel de relations durables entre les hommes et les autres composantes de l’écosphère. Elle associe étroitement la mise en valeur des ressources et la conservation des diversités biologiques et culturelles qui constituent l’identité alpine. Cet article a pour ambition de montrer : (1 comment s’organise la coordination internationale des recherches sur les

  6. Evaluating the discriminatory power of EQ-5D, HUI2 and HUI3 in a US general population survey using Shannon's indices

    NARCIS (Netherlands)

    Janssen, Mathieu F. Bas; Birnie, Erwin; Bonsel, Gouke J.

    2007-01-01

    OBJECTIVES: To compare quantitatively the discriminatory power of the EQ-5D, HUI2 and HUI3 in terms of absolute and relative informativity, using Shannon's indices. METHODS: EQ-5D and HUI2/3 data completed by a sample of the general adult US population (N = 3,691) were used. Five dimensions allowed

  7. Standard error of measurement of five health utility indexes across the range of health for use in estimating reliability and responsiveness

    Science.gov (United States)

    Palta, Mari; Chen, Han-Yang; Kaplan, Robert M.; Feeny, David; Cherepanov, Dasha; Fryback, Dennis

    2011-01-01

    Background Standard errors of measurement (SEMs) of health related quality of life (HRQoL) indexes are not well characterized. SEM is needed to estimate responsiveness statistics and provides guidance on using indexes on the individual and group level. SEM is also a component of reliability. Purpose To estimate SEM of five HRQoL indexes. Design The National Health Measurement Study (NHMS) was a population based telephone survey. The Clinical Outcomes and Measurement of Health Study (COMHS) provided repeated measures 1 and 6 months post cataract surgery. Subjects 3844 randomly selected adults from the non-institutionalized population 35 to 89 years old in the contiguous United States and 265 cataract patients. Measurements The SF6-36v2™, QWB-SA, EQ-5D, HUI2 and HUI3 were included. An item-response theory (IRT) approach captured joint variation in indexes into a composite construct of health (theta). We estimated: (1) the test-retest standard deviation (SEM-TR) from COMHS, (2) the structural standard deviation (SEM-S) around the composite construct from NHMS and (3) corresponding reliability coefficients. Results SEM-TR was 0.068 (SF-6D), 0.087 (QWB-SA), 0.093 (EQ-5D), 0.100 (HUI2) and 0.134 (HUI3), while SEM-S was 0.071, 0.094, 0.084, 0.074 and 0.117, respectively. These translate into reliability coefficients for SF-6D: 0.66 (COMHS) and 0.71 (NHMS), for QWB: 0.59 and 0.64, for EQ-5D: 0.61 and 0.70 for HUI2: 0.64 and 0.80, and for HUI3: 0.75 and 0.77, respectively. The SEM varied considerably across levels of health, especially for HUI2, HUI3 and EQ-5D, and was strongly influenced by ceiling effects. Limitations Repeated measures were five months apart and estimated theta contain measurement error. Conclusions The two types of SEM are similar and substantial for all the indexes, and vary across the range of health. PMID:20935280

  8. Outcome Assessment for Cost-Utility Evaluations: SF-6D vs. EQ-5D

    DEFF Research Database (Denmark)

    Søgaard, Rikke; Christiansen, Terkel; Christensen, Finn Bjarke

    2010-01-01

    What was formerly known as medicine has now become health care, an amalgam of several disciplines, including health economics. The role of health economics is fairly straightforward, namely to facilitate priority-setting under the objective of maximizing population health. For that purpose, cost...

  9. Diabetes and quality of life: Comparing results from utility instruments and Diabetes-39.

    Science.gov (United States)

    Chen, Gang; Iezzi, Angelo; McKie, John; Khan, Munir A; Richardson, Jeff

    2015-08-01

    To compare the Diabetes-39 (D-39) with six multi-attribute utility (MAU) instruments (15D, AQoL-8D, EQ-5D, HUI3, QWB, and SF-6D), and to develop mapping algorithms which could be used to transform the D-39 scores into the MAU scores. Self-reported diabetes sufferers (N=924) and members of the healthy public (N=1760), aged 18 years and over, were recruited from 6 countries (Australia 18%, USA 18%, UK 17%, Canada 16%, Norway 16%, and Germany 15%). Apart from the QWB which was distributed normally, non-parametric rank tests were used to compare subgroup utilities and D-39 scores. Mapping algorithms were estimated using ordinary least squares (OLS) and generalised linear models (GLM). MAU instruments discriminated between diabetes patients and the healthy public; however, utilities varied between instruments. The 15D, SF-6D, AQoL-8D had the strongest correlations with the D-39. Except for the HUI3, there were significant differences by gender. Mapping algorithms based on the OLS estimator consistently gave better goodness-of-fit results. The mean absolute error (MAE) values ranged from 0.061 to 0.147, the root mean square error (RMSE) values 0.083 to 0.198, and the R-square statistics 0.428 and 0.610. Based on MAE and RMSE values the preferred mapping is D-39 into 15D. R-square statistics and the range of predicted utilities indicate the preferred mapping is D-39 into AQoL-8D. Utilities estimated from different MAU instruments differ significantly and the outcome of a study could depend upon the instrument used. The algorithms reported in this paper enable D-39 data to be mapped into utilities predicted from any of six instruments. This provides choice for those conducting cost-utility analyses. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Rehabilitation and reconstruction of Islamic Architectural Heritage in China: the example of the Ningxia Hui Autonomous Region

    OpenAIRE

    Huang Lijun; François N. Dubé

    2015-01-01

    The Ningxia Hui Autonomous Region, located in Northwestern China, has the highest concentration of Hui Muslims in China: around 34% of the local population is Hui Muslim. Following the anti-religious campaigns of the communist regime and the wide destruction of the Cultural Revolution, Hui Muslims began gradually to reclaim their Muslim heritage in the late 70's. A major aspect of the rediscovery of their Islamic heritage was the Rehabilitation and reconstruction of Islamic Architectural buil...

  11. Prognostic analysis and comparison of colon cancer in Han and Hui patients.

    Science.gov (United States)

    Zhang, Mei; Zhao, Qu-Chuan; Liu, Yan-Peng; Yang, Lei; Zhu, Hong-Ming; Chhetri, Jagadish K

    2014-05-07

    To investigate the relevant prognostic factors and their differences between colorectal cancer (CRC) patients of Chinese Han and Hui ethnicities in the Beijing region. A retrospective analysis of 880 patients diagnosed with CRC at Xuanwu Hospital, Capital Medical University between September 2001 and September 2011 was performed. Among the 880 patients, 398 and 482 were Hui and Han, respectively. Characteristics including sex, age, diet, tumor size, primary tumor site, Dukes' stage and degree of differentiation were analyzed for their influence on prognosis. Data on dietary structures were recorded through a questionnaire survey conducted during the patient's first visit, return visit or follow-up checkups. Among patients with colon cancer, the 5-year survival rate for patients of Hui ethnicity was lower than that for Han patients (P = 0.025). Six risk factors (age of onset, dietary structure, tumor size, Dukes' stage, location of cancer and degree of differentiation) in both Han and Hui patients were identified as prognostic factors (P dietary structure was a statistically significant factor, and diet varied significantly between the two ethnic groups. Dietary structure has a significant influence on colon cancer prognosis among Han and Hui patients with colon cancer in Beijing, which may cause a difference in their survival rates.

  12. Comparison of Genetic Variants in Cancer-Related Genes between Chinese Hui and Han Populations.

    Directory of Open Access Journals (Sweden)

    Chaoyong Tian

    Full Text Available The Chinese Hui population, as the second largest minority ethnic group in China, may have a different genetic background from Han people because of its unique demographic history. In this study, we aimed to identify genetic differences between Han and Hui Chinese from the Ningxia region of China by comparing eighteen single nucleotide polymorphisms in cancer-related genes.DNA samples were collected from 99 Hui and 145 Han people from the Ningxia Hui Autonomous Region in China, and SNPs were detected using an improved multiplex ligase detection reaction method. Genotyping data from six 1000 Genomes Project population samples (99 Utah residents with northern and western European ancestry (CEU, 107 Toscani in Italy (TSI, 108 Yoruba in Ibadan (YRI, 61 of African ancestry in the southwestern US (ASW, 103 Han Chinese in Beijing (CHB, and 104 Japanese in Tokyo (JPT were also included in this study. Differences in the distribution of alleles among the populations were assessed using χ2 tests, and FST was used to measure the degree of population differentiation.We found that the genetic diversity of many SNPs in cancer-related genes in the Hui Chinese in Ningxia was different from that in the Han Chinese in Ningxia. For example, the allele frequencies of four SNPs (rs13361707, rs2274223, rs465498, and rs753955 showed different genetic distributions (p0.000 between the Hui and Han populations.These results suggest that some SNPs associated with cancer-related genes vary among different Chinese ethnic groups. We suggest that population differences should be carefully considered in evaluating cancer risk and prognosis as well as the efficacy of cancer therapy.

  13. Proof and Pedagogy in Ancient China: Examples from Liu Hui's Commentary on "JIU ZHANG SUAN SHU".

    Science.gov (United States)

    Siu, Man-Keung

    1993-01-01

    Illustrates the pedagogical implications embodied in Liu Hui's discussion on the ancient Chinese mathematical classic "JIU ZHANG SUAN SHU" (Nine Chapters on the Mathematical Art) with respect to aspects of proof and, more generally, the role of proof in mathematics. Provides examples involving area and volume. (Contains 25 references.)…

  14. Investigation of natural radioactivity level of the waters in the Ningxia Hui Autonomous Region

    International Nuclear Information System (INIS)

    Jing Yupei; Wang Li; Tian Yi; Ai Xianyuan; Liang Ningbu

    1995-01-01

    This paper reports the investigation results of natural radioactivity level in river, lake, reservoir, spring, well and tap water in the Ningxia Hui Autonomous Region. There were totally 117 samples collected from 84 measuring points. The results show that the radioactivity level of varied water bodies of the region was within normal natural background

  15. Mapping chronic liver disease questionnaire scores onto SF-6D utility values in patients with primary sclerosing cholangitis

    DEFF Research Database (Denmark)

    Kalaitzakis, Evangelos; Benito de Valle, Maria; Rahman, Monira

    2016-01-01

    regression analyses were employed to devise a mapping function predicting utilities. This was validated in three random subsamples of the cohort and in a separate sample of PSC patients following liver transplantation. Adjusted R2 and root-mean-square error (RMSE) as well as Pearson’s r coefficients and mean...

  16. Drying characteristics of hui ink at 25 °C and 35 °C

    Science.gov (United States)

    Fu, Yang; Yao, Yao; Liu, Le; Wang, Fengwen; Yang, Shuyun

    2018-05-01

    Temperature and humidity are the main factors affecting the drying of Hui ink. For the experiment, fresh Hui ink billets from two big ink industries were selected. We tried to find the fast and efficient drying conditions of Hui ink and calculate effective diffusion coefficient by performing manual control of temperature and relative humidity (RH). Several dry kinetic models were fitted. A constant temperature incubator was utilized for temperature control, while humidification and dehumidification were implemented accordingly for RH control. Setups of 25 °C and 35 °C were designed, and a relative humidity of 60%, 65%, 70%, and 75% was applied for each temperature. The process of ink drying was recorded, and the drying effect of Hui ink was estimated through expert decision. The appropriate drying temperature and humidity of the Jinbuhuan(J) and Huangshansongyan(H) ink billets from Lao Hu Kai Wen Ink Industry are at (31.99 ± 1.41) °C and (55.84 ± 10.38)% RH, whereas those of the Songyantanhei(ST), Chunyouyan(CY), and Quansongyan(QS) ink billets from Ju Mo Tang Ink Industry are at (23.70 ± 2.19) °C and (60.56 ± 2.16)% RH or (34.56 ± 2.37) °C and (59.16 ± 6.38)% RH; Initial moisture content of Hui ink has great influence on the water loss in the drying process; The effective diffusion coefficient of the ink lump ranges from 8.41538E-07 to 1.95891E-06 m2·s-1, and increases mainly with the temperature's rising; Logarithmic model fits best of the chosen models.

  17. Rehabilitation and reconstruction of Islamic Architectural Heritage in China: the example of the Ningxia Hui Autonomous Region

    Directory of Open Access Journals (Sweden)

    Huang Lijun

    2015-06-01

    Full Text Available The Ningxia Hui Autonomous Region, located in Northwestern China, has the highest concentration of Hui Muslims in China: around 34% of the local population is Hui Muslim. Following the anti-religious campaigns of the communist regime and the wide destruction of the Cultural Revolution, Hui Muslims began gradually to reclaim their Muslim heritage in the late 70's. A major aspect of the rediscovery of their Islamic heritage was the Rehabilitation and reconstruction of Islamic Architectural buildings. As of today, Ningxia counts 4,500 mosques and other religious buildings. The present article seeks to introduce the architectural tendencies at play in this reconstruction, specifically the role of competing Arabic and Chinese influences.

  18. Measuring health-related quality of life in population-based studies of coronary heart disease: comparing six generic indexes and a disease-specific proxy score.

    Science.gov (United States)

    Garster, Noelle C; Palta, Mari; Sweitzer, Nancy K; Kaplan, Robert M; Fryback, Dennis G

    2009-11-01

    To compare HRQoL differences with CHD in generic indexes and a proxy CVD-specific score in a nationally representative sample of U.S. adults. The National Health Measurement Study, a cross-sectional random-digit-dialed telephone survey of adults aged 35-89, administered the EQ-5D, QWB-SA, HUI2, HUI3, SF-36v2 (yielding PCS, MCS, and SF-6D), and HALex. Analyses compared 3,350 without CHD (group 1), 265 with CHD not taking chest pain medication (group 2), and 218 with CHD currently taking chest pain medication (group 3), with and without adjustment for demographic variables and comorbidities. Data on 154 patients from heart failure clinics were used to construct a proxy score utilizing generic items probing CVD symptoms. Mean scores differed between CHD groups for all indexes with and without adjustment (P < 0.0001 for all except MCS P = 0.018). Unadjusted group 3 versus 1 differences were about three times larger than for group 2 versus 1. Standardized differences for the proxy score were similar to those for generic indexes, and were about 1.0 for all except MCS for group 3 versus 1. Generic indexes capture differences in HRQoL in population-based studies of CHD similarly to a score constructed from questions probing CVD-specific symptoms.

  19. Measuring health-related quality of life for child maltreatment: a systematic literature review

    Directory of Open Access Journals (Sweden)

    Prosser Lisa A

    2007-07-01

    Full Text Available Abstract Background Child maltreatment causes substantial morbidity and mortality in the U.S. Morbidity associated with child maltreatment can reduce health-related quality of life. Accurately measuring the reduction in quality of life associated with child maltreatment is essential to the economic evaluation of educational programs and interventions to reduce the incidence of child maltreatment. The objective of this study was to review the literature for existing approaches and instruments for measuring quality-of-life for child maltreatment outcomes. Methods We reviewed the current literature to identify current approaches to valuing child maltreatment outcomes for economic evaluations. We also reviewed available preference-based generic QOL instruments (EQ-5D, HUI, QWB, SF-6D for appropriateness in measuring change in quality of life due to child maltreatment. Results We did not identify any studies that directly evaluated quality-of-life in maltreated children. We identified 4 studies that evaluated quality of life for adult survivors of child maltreatment and 8 studies that measured quality-of-life for pediatric injury not related to child maltreatment. No study reported quality-of-life values for children younger than age 3. Currently available preference-based QOL instruments (EQ-5D, HUI, QWB, SF-6D have been developed primarily for adults with the exception of the Health Utilities Index. These instruments do not include many of the domains identified as being important in capturing changes in quality of life for child maltreatment, such as potential for growth and development or psychological sequelae specific to maltreatment. Conclusion Recommendations for valuing preference-based quality-of-life for child maltreatment will vary by developmental level and type of maltreatment. In the short-term, available multi-attribute utility instruments should be considered in the context of the type of child maltreatment being measured. However

  20. Association Study between Polycystic Ovarian Syndrome and the Susceptibility Genes Polymorphisms in Hui Chinese Women.

    Directory of Open Access Journals (Sweden)

    Lingxia Ha

    Full Text Available Polycystic ovary syndrome (PCOS is one of the most common endocrine-metabolic disorders. Evidence of familial aggregation analysis and different clinical traits among different regions and ethnicities indicated that the pathogenesis of PCOS is associated with multiple genetic and environmental factors. Our previous research had identified three susceptibility loci (rs2479106, DENND1A; rs13405728, LHCGR; rs13429458, THADA for PCOS in Han Chinese women. The overall aim of this study was to investigate the relationship between three susceptibility gene polymorphisms and PCOS in Hui ethnic women.151 patients with PCOS (case group and 99 healthy women (control group were recruited from the Reproductive Medicine Center of the General Hospital of Ningxia Medical University. Clinical data and serum hormone characteristics of case and control groups were collected and analyzed. The three susceptibility single-nucleotide polymorphisms have been replicated in both case and control groups. Gene polymorphisms were detected by direct sequencing after polymerase chain reaction.The Body Mass Index, LH, LH/FSH ratio and total testosterone were significantly elevated in PCOS patients compared to control group (P0.05.The present study suggested that the SNP rs13405728 in the LHCGR gene was associated with PCOS in Hui ethnic women, and its TT genotype characterized with higher level of TT, TG and LDL.

  1. Mapping MOS-HIV to HUI3 and EQ-5D-3L in Patients With HIV

    Directory of Open Access Journals (Sweden)

    Vilija R. Joyce MS

    2017-07-01

    Full Text Available Objectives: The Medical Outcomes Study HIV Health Survey (MOS-HIV is frequently used in HIV clinical trials; however, scores generated from the MOS-HIV are not suited for cost-effectiveness analyses as they do not assign utility values to health states. Our objective was to estimate and externally validate several mapping algorithms to predict Health Utilities Index Mark 3 (HUI3 and EQ-5D-3L utility values from the MOS-HIV. Methods: We developed and validated mapping algorithms using data from two HIV clinical trials. Data from the first trial (n = 367 formed the estimation data set for the HUI3 (4,610 observations and EQ-5D-3L (4,662 observations mapping algorithms; data from the second trial (n = 168 formed the HUI3 (1,135 observations and EQ-5D-3L (1,152 observations external validation data set. We compared ordinary least squares (OLS models of increasing complexity with the more flexible two-part, beta regression, and finite mixture models. We assessed model performance using mean absolute error (MAE and mean squared error (MSE. Results: The OLS model that used MOS-HIV dimension scores along with squared terms gave the best HUI3 predictions (mean observed 0.84; mean predicted 0.80; MAE 0.0961; the finite mixture model gave the best EQ-5D-3L predictions (mean observed 0.90; mean predicted 0.88; MAE 0.0567. All models produced higher prediction errors at the lower end of the HUI3 and EQ-5D-3L score ranges (<0.40. Conclusions: The proposed mapping algorithms can be used to predict HUI3 and EQ-5D-3L utility values from the MOS-HIV, although greater error may pose a problem in samples where a substantial proportion of patients are in poor health. These algorithms may be useful for estimating utility values from the MOS-HIV for cost-effectiveness studies when HUI3 or EQ-5D-3L data are not available.

  2. Measurement of utility.

    Science.gov (United States)

    Thavorncharoensap, Montarat

    2014-05-01

    The Quality Adjusted Life Year (QALY) is the most widely recommended health outcome measure for use in economic evaluations. The QALY gives a value to the effect of a given health intervention in terms of both quantity and quality. QALYs are calculated by multiplying the duration of time spent in a given health state, in years, by the quality of life weighted, known as utility. Utility can range from 0 (the worst health state-the equivalent of death) to 1 (the best health state-full health). This paper provides an overview of the various methods that can be used to measure utility and outlines the recommended protocol for measuring utility, as described in the Guidelines for Health Technology Assessment in Thailand (second edition). The recommendations are as follows: Wherever possible, primary data collection using EQ-5D-3L in patients using Thai value sets generated from the general public should be used. Where the EQ-5D-3L is considered inappropriate, other methods such as Standard gamble (SG), Time-trade-off (TTO), Visual analogue scale (VAS), Health Utilities Index (HUI), SF-6D, or Quality of well being (QWB) can be used. However, justification and full details on the chosen instrument should always be provided.

  3. Drought Adaptation in the Ningxia Hui Autonomous Region, China: Actions, Planning, Pathways and Barriers

    Directory of Open Access Journals (Sweden)

    Jianping Yang

    2015-11-01

    Full Text Available The Ningxia Hui Autonomous Region (NX region of Northwestern China is threatened by increased meteorological drought induced by climate change (CC and constraints on water supply from the Yellow River. Thus, the NX region is representative of attempts to adapt to CC and variability in China’s arid regions. Field visits, a questionnaire and in situ inspections were conducted in 2012–2014 to understand people’s perception and awareness of drought and its impact, particularly with respect to adaptation strategies. We mainly focused on drought adaptation actions and planning implemented at the government level under the double pressures of drought and allocation. We described a suitable adaptation pathway for socio-economic sustainable development and discussed existing adaptation barriers. Construction of modern efficient water-saving agriculture lies at the core of drought adaptation, with socio-economic sustainable development being the ultimate goal. To achieve this, policies and institutional, engineering, technological, structural and social initiatives and measures—classified into macro adaptation strategies and specific coping measures—are implemented. Adaptation often encounters obstacles, e.g., policy issues from household contract responsibility systems, funding difficulties of low-income farmers, traditional behavioral habits and low education and literacy levels among farmers. The adaptation pathway involves the construction of modern efficient water-saving agriculture. Agricultural water savings are then transferred to developed industries, which back-feed socio-economic sustainable development in the NX region.

  4. Marie Curie, les femmes et la science, d'hier à aujourd'hui - English

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Marie Curie, les femmes et la science, d'hier à aujourd'hui Conférence par Hélène Langevin-Joliot Avec la participation de l'Echo du Reculet de Thoiry. L'enregistrement et la liste d'attente sont déjà complets... Mais il n'est pas rare que des personnes réservent et ne viennent pas. Nous réassignerons les places libérées selon la règle "premier arrivé, premier inscrit". Nous envisageons la possibilité de faire un webcast de la conférence. Plus d'information bientôt. Hélène Langevin-Joliot, directrice de recherche émérite en physique nucléaire fondamentale au CNRS à Orsay, est aussi la fille de Frédéric et Irène Joliot-Curie (prix Nobel de chimie en 1935) et la petite-fille de Pierre Curie (prix Nobel de physique en 1903) et de Marie Curie (prix Nobel de physique en 1903 et prix Nobel de chimie en 1911). Hélène Langevin-Joliot nous parlera de sa vie scientifique, de l’histoire extraordinaire de sa famille et en particulier du rôle des ...

  5. Marie Curie, les femmes et la science, d'hier à aujourd'hui

    CERN Multimedia

    CERN. Geneva; Mariotti, Chiara; Vicinanza, Domenico

    2017-01-01

    Marie Curie, les femmes et la science, d'hier à aujourd'hui Conférence par Hélène Langevin-Joliot Avec la participation de l'Echo du Reculet de Thoiry. L'enregistrement et la liste d'attente sont déjà complets... Mais il n'est pas rare que des personnes réservent et ne viennent pas. Nous réassignerons les places libérées selon la règle "premier arrivé, premier inscrit". Au vu de la forte demande, la conférence sera également disponible en vidéoconférence : lien d'accès "webcast" disponible en bas de cette page. Hélène Langevin-Joliot, directrice de recherche émérite en physique nucléaire fondamentale au CNRS à Orsay, est aussi la fille de Frédéric et Irène Joliot-Curie (prix Nobel de chimie en 1935) et la petite-fille de Pierre Curie (prix Nobel de physique en 1903) et de Marie Curie (prix Nobel de physique en 1903 et prix Nobel de chimie en 1911). Hélène Langevin-Joliot nous parlera de sa vie scientifique, de l’histoire extraordinai...

  6. Appendix I1-2 to Wind HUI Initiative 1: Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    John Zack; Deborah Hanley; Dora Nakafuji

    2012-07-15

    This report is an appendix to the Hawaii WindHUI efforts to dev elop and operationalize short-term wind forecasting and wind ramp event forecasting capabilities. The report summarizes the WindNET field campaign deployment experiences and challenges. As part of the WindNET project on the Big Island of Hawaii, AWS Truepower (AWST) conducted a field campaign to assess the viability of deploying a network of monitoring systems to aid in local wind energy forecasting. The data provided at these monitoring locations, which were strategically placed around the Big Island of Hawaii based upon results from the Oahu Wind Integration and Transmission Study (OWITS) observational targeting study (Figure 1), provided predictive indicators for improving wind forecasts and developing responsive strategies for managing real-time, wind-related system events. The goal of the field campaign was to make measurements from a network of remote monitoring devices to improve 1- to 3-hour look ahead forecasts for wind facilities.

  7. [Carbon sequestration status of forest ecosystems in Ningxia Hui Autonomous Region].

    Science.gov (United States)

    Gao, Yang; Jin, Jing-Wei; Cheng, Ji-Min; Su, Ji-Shuai; Zhu, Ren-Bin; Ma, Zheng-Rui; Liu, Wei

    2014-03-01

    Based on the data of Ningxia Hui Autonomous Region forest resources inventory, field investigation and laboratory analysis, this paper studied the carbon sequestration status of forest ecosystems in Ningxia region, estimated the carbon density and storage of forest ecosystems, and analyzed their spatial distribution characteristics. The results showed that the biomass of each forest vegetation component was in the order of arbor layer (46.64 Mg x hm(-2)) > litterfall layer (7.34 Mg x hm(-2)) > fine root layer (6.67 Mg x hm(-2)) > shrub-grass layer (0.73 Mg x hm(-2)). Spruce (115.43 Mg x hm(-2)) and Pinus tabuliformis (94.55 Mg x hm(-2)) had higher vegetation biomasses per unit area than other tree species. Over-mature forest had the highest arbor carbon density among the forests with different ages. However, the young forest had the highest arbor carbon storage (1.90 Tg C) due to its widest planted area. Overall, the average carbon density of forest ecosystems in Ningxia region was 265.74 Mg C x hm(-2), and the carbon storage was 43.54 Tg C. Carbon density and storage of vegetation were 27.24 Mg C x hm(-2) and 4.46 Tg C, respectively. Carbon storage in the soil was 8.76 times of that in the vegetation. In the southern part of Ningxia region, the forest carbon storage was higher than in the northern part, where the low C storage was mainly related to the small forest area and young forest age structure. With the improvement of forest age structure and the further implementation of forestry ecoengineering, the forest ecosystems in Ningxia region would achieve a huge carbon sequestration potential.

  8. « Comment le sais-tu ? ». La paralepse, aujourd’hui

    Directory of Open Access Journals (Sweden)

    Frank Wagner

    2013-04-01

    Full Text Available À partir des définitions genettiennes de la paralepse (excès d’informations par rapport au code modal dominant, il s’agit de cerner les usages et les fonctions du procédé dans la littérature narrative d’aujourd’hui, en relation homo- ou hétérodiégétique, en régime fictionnel ou semi-fictionnel. Des exemples prélevés dans divers récits contemporains (de Roegiers, Toussaint, Carrère, Echenoz permettent de constater que la paralepse assure un renouvellement du soupçon à l’époque actuelle, en jouant un rôle de révélateur épistémologique. En effet, ce procédé narratif paradoxal engage une réflexion en acte sur la fiction, son perspectivisme, ses capacités de modélisation, et ses pouvoirs heuristiques.Based upon Gerard Genette’s definitions of paralepsis, (information exceeding that normally offered by the dominant mode of narrative focalisation, this article seeks to outline the uses and functions of the device in contemporary narrative literature, through its homo and heterodiegetic positioning in both fictional and semi-fictional texts. Examples taken from a variety of contemporary stories (Roegiers, Toussaint, Carrère, Echenoz allow us to see that paralepsis plays a role of epistemological indicator, facilitating a contemporary renewal of suspicion (le soupçon concerning narration. In fact, this paradoxical narrative device brings about a reflection upon fiction, its perspectivism, its modelling capabilities and heuristic capacities.

  9. Using Health Utility Index (HUI for Measuring the Impact on Health-Related Quality of Life (HRQL Among Individuals with Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Frank Mo

    2004-01-01

    Full Text Available Quality of life is an important indicator in assessing the burden of disease, especially for chronic conditions. The Health Utilities Index (HUI is a recently developed system for measuring the overall health status and health-related quality of life (HRQL of individuals, clinical groups, and general populations. Using the HUI (constructed based on eight attributes: vision, hearing, speech, mobility, dexterity, cognition, emotion, and pain/discomfort to measure the HRQL for chronic disease patients and to detect possible associations between HUI system and various chronic conditions, this study provides information to improve the management of chronic diseases.This study is of interest to data analysts, policy makers, and public health practitioners involved in descriptive clinical studies, clinical trials, program evaluation, population health planning, and assessments. Based on the Canadian Community Health Survey (CCHS for 2000–01, the HUI was used to measure the quality of life for individuals living with various chronic conditions (Alzheimer/other dementia, effects of stroke, urinary incontinence, arthritis/rheumatism, bowel disorder, cataracts, back problems, stomach/intestinal ulcers, emphysema/COPD, chronic bronchitis, epilepsy, heart disease, diabetes, migraine headaches, glaucoma, asthma, fibromyalgia, cancers, high blood pressure, multiple sclerosis, thyroid condition, and other remaining chronic diseases. Logistic Regression Model was employed to estimate the associations between the overall HUI scores and various chronic conditions. The HUI scores ranged from 0.00 (corresponding to a state close to death to 1.00 (corresponding to perfect health; negative scores reflect health states considered worse than death. The mean HUI score by sex and age group indicated the typical quality of life for persons with various chronic conditions. Logistic Regression results showed a strong relationship between low HUI scores (≤ 0.5 and 0.06

  10. A Novel Pharmacological Method to Study the Chinese Medicinal Formula Hua-Zheng-Hui-Sheng-Dan

    Directory of Open Access Journals (Sweden)

    Rui Cao

    2015-01-01

    Full Text Available Objectives. Hua-Zheng-Hui-Sheng-Dan (HZHSD was used as an experimental model to explore research methods of large formulae in traditional Chinese medicine (TCM using current molecular biology approaches. Materials and Methods. The trypan blue exclusion assay was used to determine cell viability and cell numbers. Flow cytometry was used to assess cell cycle distribution and apoptosis. The concentration of cyclin D1 was analyzed by enzyme-linked immunosorbent assay. The median effect principle was used in drug combination studies. An orthogonal experimental design was used to estimate the effects of each herb at different concentrations. The HeLa xenograft mouse model was used to compare the antitumor activity of drugs in vivo. Results. Among the 35 herbs that comprise HZHSD, Radix Rehmanniae Preparata (RRP, Caesalpinia sappan (CS, Evodia rutaecarpa (ER, Folium Artemisiae Argyi (FAA, Leonurus japonicus Houtt (LJH, Tumeric (Tu, Radix Paeoniae Alba (RPA, and Trogopterus Dung (TD effectively inhibited the proliferation of HeLa and SKOV3 cells. Only RRR had an effect on HeLa and SKOV3 cell viability. According to the median effect principle, Angelica sinensis (Oliv. (AS, Tabanus (Ta, and Pollen Typhae (PT, which were proven to have a significant synergistic inhibitory effect on the proliferation of HeLa cells, were added to the original eight positive herbs. The combination of RPA and AS had a synergistic effect on inducing cell cycle S phase arrest and decreasing intracellular cyclin D1 in HeLa cells. By orthogonal experimental design, LJH and Tu were considered unnecessary herbs. The small formula (SHZHSD consisted of RPA, AS, RRR, Ta., TD, PT, ER, CS, and FAA and was able to inhibit cell proliferation and induce cell apoptosis. The antitumor effects of HZHSD and SHZHSD were also compared in vivo. Conclusions. Through molecular biology approaches both in vitro and in vivo, research into single drugs, and analysis using the median effect principle

  11. Identification and phylogenetic analysis of a sheep pox virus isolated from the Ningxia Hui Autonomous Region of China.

    Science.gov (United States)

    Zhu, X L; Yang, F; Li, H X; Dou, Y X; Meng, X L; Li, H; Luo, X N; Cai, X P

    2013-05-14

    An outbreak of sheep pox was investigated in the Ningxia Hui Autonomous Region in China. Through immunofluorescence testing, isolated viruses, polymerase chain reaction identification, and electron microscopic examination, the isolated strain was identified as a sheep pox virus. The virus was identified through sequence and phylogenetic analysis of the P32 gene, open reading frame (ORF) 095, and ORF 103 genes. This study is the first to use the ORF 095 and ORF 103 genes as candidate genes for the analysis of sheep pox. The results showed that the ORF 095 and ORF 103 genes could be used for the genotyping of the sheep pox virus.

  12. Transaction Pattern Based on Secondary Clientelism, Business Ideology and Market Development: The case of lime market in Hui Town

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Secondary clientelism is a special exchange relationship derived from primary clientelism. The market with transactions dependent on the secondary clientelism would be”because of”erembeddedness”. Using the lime market in Hui Town as a case, this paper tries to explore why this kind of markets could achieve market order from the perspective of the interconnection of market structure and market culture. Analysis demonstrates that, the coupling induction of structural embeddedness and cultural embeddedness is the deeper mechanism for the market development. Although the new business ideology and transactional dependence on networks originate from market structural transitions, active construction and choice behaviors of the manufacturers still manifest great importance.

  13. Hawaii Utility Integration Initiatives to Enable Wind (Wind HUI) Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Dora Nakafuji; Lisa Dangelmaier; Chris Reynolds

    2012-07-15

    monitoring using PMU devices and enhanced grid analysis tools; and Initiative 3: Identifying grid automation and smart technology architecture retrofit/improvement opportunities following a systematic review approach, inclusive of increasing renewables and variable distributed generation. Each of the initiative was conducted in partnership with industry technology and equipment providers to facilitate utility deployment experiences inform decision making, assess supporting infrastructure cost considerations, showcase state of the technology, address integration hurdles with viable workarounds. For each initiative, a multi-phased approach was followed that included 1) investigative planning and review of existing state-of-the-art, 2) hands on deployment experiences and 3) process implementation considerations. Each phase of the approach allowed for mid-course corrections, process review and change to any equipment/devices to be used by the utilities. To help the island grids transform legacy infrastructure, the Wind HUI provided more systematic approaches and exposure with vendor/manufacturers, hand-on review and experience with the equipment not only from the initial planning stages but through to deployment and assessment of field performance of some of the new, remote sensing and high-resolution grid monitoring technologies. HELCO became one of the first utilities in the nation to install and operate a high resolution (WindNet) network of remote sensing devices such as radiometers and SODARs to enable a short-term ramp event forecasting capability. This utility-industry and federal government partnership produced new information on wind energy forecasting including new data additions to the NOAA MADIS database; addressed remote sensing technology performance and O&M (operations and maintenance) challenges; assessed legacy equipment compatibility issues and technology solutions; evaluated cyber-security concerns; and engaged in community outreach opportunities that will

  14. [Flipping moxibustion of Hui medicine combined with western medication for rheumatoid arthritis with cold dampness bi syndrome].

    Science.gov (United States)

    Wang, Shunji; Ye, Gaxi; Zhang, Yu; Guan, Shuting; Liu, Xiufen; Ren, Wenjing

    2017-10-12

    To compare the effects of flipping moxibustion of Hui medicine combined with western medication and simple western medication for rheumatoid arthritis with cold dampness bi syndrome. Eighty patients were randomly assigned into an observation group and a control group, 40 cases in each group. Oral methotrexate (1 time a week) and sulfasalazine (twice a day except the day for methotrexate) were used in the two groups. Patients in the observation group were treated with flipping moxibustion of Hui medicine, twice a week. The main acupoints were Shenshu (BL 23), Guanyuan (CV 4), Zusanli (ST 36), Yinlingquan (SP 9), and the matching acupoints were in the meridians related to the disease location. All the treatment was given for continuous 4 weeks. The TCM symptom score, visual analogue scale (VAS) score, blood sedimentation (ESR), rheumatoid factor (RF) and C-reactive protein (CRP) were observed before and after treatment. The effect was evaluated. The total effect rate in the observation group was 95.0% (38/40), which was better than 77.5% (31/40) in the control group ( P bi syndrome are better than simple western medication, which are safer and more effective.

  15. La république en Grande-Bretagne aujourd’hui : une idée anglaise

    Directory of Open Access Journals (Sweden)

    Antoine MIOCHE

    2003-10-01

    Full Text Available Il peut paraître y avoir un paradoxe à parler de république aujourd’hui en Grande-Bretagne en ceci que seule ou presque la Grande-Bretagne, de ce qui fut le vaste Empire britannique, est demeurée une monarchie. Des États-Unis à la Rhodésie, en passant par l’Inde et l’Irlande (à l’exception importante du nord de l’île, les anciens territoires britanniques ont opté majoritairement pour un régime parlementaire non monarchique, l’Australie, le Canada et la Nouvelle-Zélande étant d’intéressantes ...

  16. [Improvement of universal salt iodization program on the intelligence quotient among children in Linxia Hui Autonomous Prefecture of Gansu].

    Science.gov (United States)

    Cao, Yong-qin; Wang, Yan-ling; Zhu, Xiao-nan; Dou, Yu-gui; Li, Hong-bo; Sun, Wei; Zheng, Jing

    2012-09-01

    To assess the improvement of intelligence quotient through an Universal Salt Iodization Supply Program, among children. 3518 and 1611 children were selected from primary schools in Linxia Hui Autonomous Prefecture of Gansu in 2006 and 2010 respectively. Intelligence quotient (IQ) were measured by the revised Chinese Combined Raven Test-C2 (CRT-C2). In 2006, the average IQ of children aged 8-10 was 85.1, including 16.7% of them with IQ ≤ 69. The average IQ was between 80-90 in different counties and cities, with significant differences (P 0.05). The average IQ of children aged 8-10 in 2010 was 97.2 and 12 points higher than in 2006 (P 0.05), but in boys (98.8) and in girls (95.9) the difference was significant (P intelligence. However, the average IQ was still lower than the average level of the whole Gansu province in 2010.

  17. Business Ethics of The Hui Nationality & Its Contemporary Significance%回族的商业伦理思想及其当代意义

    Institute of Scientific and Technical Information of China (English)

    张晓华; 吕广文

    2012-01-01

      回族起源于唐宋时期阿拉伯地区的来华商人,是一个以商为本的民族。回族商人在长期的经济活动中形成了一套集法律、宗教、道德于一体的商业伦理思想,在这一独具特色思想的指导下,回民族的经济健康、有序地发展,民族不断繁荣强大。在今天的社会主义市场经济体制下,弘扬回族商业伦理思想,仍然具有十分重要的现实指导意义。%  The Hui Nationality originated from the Arabian merchants came to china in the Tang and Song Dynasties, it is a business-oriented nation. By the long-term economic activities, Hui merchants formed a set of business ethics incorporating the law, religion and morality. Under the guidance of this unique idea, Hui's economy achieves sound and orderly development, and their nation becomes more and more prosperous and powerful. In the context of today’s socialist market economic system, carrying forward the business ethics of the Hui Nationality sill has important practical and guiding significance.

  18. 回族独特法律意识成因初探%The Preliminary Study on the Hui Ethnicity Unique Legal Consciousness

    Institute of Scientific and Technical Information of China (English)

    高研秋

    2015-01-01

    As a special form of social consciousness ,legal consciousness is the general name of people’ s thinking about the law and legal phenomena ,concepts ,ideas ,knowledge and psychology .Contemporary Hui ethnicity legal consciousness ,which is a special awareness of the law ,is different from legal con‐sciousness of Han nationality . Based on the empirical investigation of contemporary Hui ethnicity students’ legal consciousness ,this paper obtained the following causes of Hui ethnicity legal conscious‐ness:the cultural core settled dow n from the formation of the Hui nationality ,w hich survived from the Han cultural identity and change with its own characteristics ;sharia law and ethics contained in Koran and hadith is a determining factor on the formation of Hui ethnicity legal consciousness ;mosque education is a special educational support and place for Hui people learning and passing on their religious law .%法律意识是社会意识的一个特殊形式,是人们关于法和法律现象的思想、理念、观点、知识和心理的总和。当代回族法律意识作为一种特殊群体的法律意识有别于汉族法律意识。本文在实证调查基础之上,得出了以下回族法律意识成因:回族族群的形成过程中,与汉文化的认同与变迁中沉淀下来的“融而不化”、“和而不同”的文化内核;《古兰经》、“圣训”蕴含的伊斯兰教法及道德规范对回族法律意识观的形成具有决定因素;回族群众具有特殊的教育载体及特殊的宗教法传习场所———“经堂”。

  19. Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People's Republic of China.

    Science.gov (United States)

    Yang, Yu Rong; Clements, Archie C A; Gray, Darren J; Atkinson, Jo-An M; Williams, Gail M; Barnes, Tamsin S; McManus, Donald P

    2012-07-24

    Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR), the People's Republic of China (PRC), has led to dramatic increases in deforestation and modified agricultural practices. In turn, this has resulted in many changes in the habitats for the definitive and intermediate hosts of both Echinococcus granulosus and E. multilocularis, which have increased the risks for transmission of both parasites, affecting echinococcosis prevalence and human disease. Ecological environmental changes due to anthropogenic activities and natural events drive Echinococcus transmission and NHAR provides a notable example illustrating how human activity can impact on a parasitic infection of major public health significance. It is very important to continually monitor these environmental (including climatic) factors that drive the distribution of Echinococcus spp. and their impact on transmission to humans because such information is necessary to formulate reliable future public health policy for echinococcosis control programs and to prevent disease spread.

  20. De middeleeuwse ambachtelijke wijk van Pamele (stad Oudenaarde, Oost-Vlaanderen). Het onderzoek in het Huis de Lalaing. 1. De pottenbakkersovens

    OpenAIRE

    De Groote, K.

    1994-01-01

    In april 1988 werd pottenbakkersafval aangetroffen bij graafwerken op de binnenkoer van het Huis de Lalaing te Oudenaarde. Dankzij de snelle tussenkomst van het stadsbestuur, en in het bijzonder van de toenmalige schepen van cultuur, Jean-Pierre Van der Meiren, werden de werken stilgelegd. Het bedreigde terrein, dat eigendom is van de stad, werd voor archeologisch onderzoek ter beschikking gesteld van het I.A.P.. De opgravingen werden voltooid in januari 1989

  1. Appendix I3-1 to Wind HUI Initiative 1: AWST-WindNET-Phase 1 Final Report

    Energy Technology Data Exchange (ETDEWEB)

    John Zack

    2012-07-15

    This report is an appendix to the Hawaii WindHUI efforts to develop and operationalize short-term wind forecasting and wind ramp event forecasting capabilities. The report summarizes the WindNET Phase 1 efforts on the Big Island of Hawaii and includes descriptions of modeling methodologies, use of field validation data, results and recommendations. The objective of the WindNET project was to investigate the improvement that could be obtained in short-term wind power forecasting for wind generation facilities operating on the island grids operated by Hawaiian Electric Companies through the use of atmospheric sensors deployed at targeted locations. WindNET is envisioned as a multiphase project that will address the short-term wind forecasting issues of all of the wind generation facilities on the all of the Hawaiian Electric Companies' island grid systems. The first phase of the WindNET effort (referred to as WindNET-1) was focused on the wind generation facilities on the Big Island of Hawaii. With complex terrain and marine environment, emphasis was on improving the 0 to 6 hour forecasts of wind power ramps and periods of wind variability, with a particular interest in the intra-hour (0-1 hour) look-ahead period. The WindNET project was built upon a foundation that was constructed with the results from a previously completed observation targeting study for the Big Island that was conducted as part of a project supported by the National Renewable Energy Laboratory (NREL) and interactions with the western utilities. The observational targeting study provided guidance on which variables to measure and at what locations to get the most improvement in forecast performance at a target forecast site. The recommendations of the observation targeting study were based on the application two techniques: (1) an objective method called ensemble sensitivity analysis (ESA) (Ancell and Hakim, 2007; Torn and Hakim, 2008; Zack et al, 2010); and (2) a subjective method based on a

  2. Comment on “Time-changed geometric fractional Brownian motion and option pricing with transaction costs” by Hui Gu et al.

    Science.gov (United States)

    Guo, Zhidong; Song, Yukun; Zhang, Yunliang

    2013-05-01

    The purpose of this comment is to point out the inappropriate assumption of “3αH>1” and two problems in the proof of “Theorem 3.1” in section 3 of the paper “Time-changed geometric fractional Brownian motion and option pricing with transaction costs” by Hui Gu et al. [H. Gu, J.R. Liang, Y. X. Zhang, Time-changed geometric fractional Brownian motion and option pricing with transaction costs, Physica A 391 (2012) 3971-3977]. Then we show the two problems will be solved under our new assumption.

  3. Le chamanisme, un projet d’étude scientifique aujourd’hui. À propos d’un article de H. Rydving

    OpenAIRE

    Stépanoff, Charles

    2013-01-01

    Dans son article « Le chamanisme aujourd’hui : constructions et déconstructions d’une illusion scientifique », Håkan Rydving entend démontrer le caractère inopérant et même néfaste des notions de « chamane » et « chamanisme » en anthropologie. Selon lui, leur emploi donne une illusion de familiarité qui nuit à la description circonstanciée du contexte social, historique et culturel des phénomènes étudiés. Il considère ainsi que : « la traduction de böö, noaidi, angakkoq, etc. par ‘chamane’ ca...

  4. Traduire encore Bertin aujourd'hui : pourquoi faire ? Les nouvelles faces cachées de la Sémiologie Graphique

    Science.gov (United States)

    Dhieb, Mohsen

    2018-05-01

    La « Sémiologie Graphique » de Bertin est un ouvrage majeur de la cartographie contemporaine. Cependant, dès sa parution en 1967, cet ouvrage a suscité autant d'intérêt que de méfiance : l'ouvrage n'était pas dans le « moule » de la littérature cartographique en vigueur. Pourtant, si plusieurs de ses principes et concepts fondateurs ont été adoptés, plusieurs autres ne sont pas bien passés ou n'ont pas été mis en pratique. Il y a comme un fossé entre certains énoncés théoriques de l'ouvrage et leur mise en pratique. Certaines affirmations de Bertin peuvent paraître obsolètes aujourd'hui à l'heure du numérique, comme la non prise en compte de l'aspect dynamique ou interactif de la carte. L'avènement récent des SIG, de la géomatique et des systèmes de Cartographie Assistée par Ordinateur a relégué les vieilles méthodes de traitement graphique de l'information au second rang. Dès lors pourquoi traduire encore aujourd'hui, à l'heure du numérique, la « Sémiologie Graphique » ? Justement, d'abord, parce que certains principes restent, en substance, peu connus ; plusieurs aspects demeurent encore à explorer ; certaines méthodes et techniques manuelles délaissées peuvent être revisitées et remises en marche grâce à la visualisation ; des innovations n'ont pas été expérimentées ou implémentées par les moyens numériques. Dans le monde arabe, peu de recherches se sont imprégnées de sémiologie graphique. Lors de la traduction de l'ouvrage en arabe, des points restés obscurs ont été décelés. Ce sont ces quelques idées et réflexions qui nous ont poussés à revivre cette formidable aventure.

  5. The role and significance of Luo Zhiyuan's Shu yi hui bian in the history of plague in Lingnan (south of the five ridges).

    Science.gov (United States)

    Li, H; Lai, W

    1999-04-01

    Being the earliest monograph on plague in China, Luo Zhiyuan's Shu yi hui bian, not included in the National Catalogue of TCM Books, include the following contents: personal idea on the etiology of plague; Luo's friend Wu Xuanchang' unpublished Shu yu zhi fa on the treatment and manifestations of plague; Luo's specific recipe for plague based on medified Wang Qingren's Jie du huo xue decoction based on Wang Qingrens yi lin gai cuo; therapy for critical cases; many therapies applied on Lingnan, including experimental recipes, external therapy, preventive methods, and preventing recurrence methods; Luo's special administrating methods, including persisting day-and-night method, immediate persisting method, single-dose persisting method, and double-dose persisting method. He also gave several cured case records. His book, featuring unique idea with good effect, was repeatedly printed and extensively distributed, exerting influence, more or less, on the plague monographs of later ages, and occupying important position in the history of plague on Lingnan and the whole country as well. His idea of "that poisons and static blood" in pathogenesis and therapeutic principle of antitoxicity and activating blood is coincided with the results of present day clinical and laboratory studies. His administration of medicines is heuristic to the therapy of critical cases with Chinese medicaments and to the recognition of pathogenesis, etiology, and treatment of modern plague as well as other diseases of similar etiology and pathognesis and is worth of further study.

  6. Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People’s Republic of China

    Science.gov (United States)

    2012-01-01

    Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR), the People’s Republic of China (PRC), has led to dramatic increases in deforestation and modified agricultural practices. In turn, this has resulted in many changes in the habitats for the definitive and intermediate hosts of both Echinococcus granulosus and E. multilocularis, which have increased the risks for transmission of both parasites, affecting echinococcosis prevalence and human disease. Ecological environmental changes due to anthropogenic activities and natural events drive Echinococcus transmission and NHAR provides a notable example illustrating how human activity can impact on a parasitic infection of major public health significance. It is very important to continually monitor these environmental (including climatic) factors that drive the distribution of Echinococcus spp. and their impact on transmission to humans because such information is necessary to formulate reliable future public health policy for echinococcosis control programs and to prevent disease spread. PMID:22827890

  7. Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People’s Republic of China

    Directory of Open Access Journals (Sweden)

    Yang Yu

    2012-07-01

    Full Text Available Abstract Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR, the People’s Republic of China (PRC, has led to dramatic increases in deforestation and modified agricultural practices. In turn, this has resulted in many changes in the habitats for the definitive and intermediate hosts of both Echinococcus granulosus and E. multilocularis, which have increased the risks for transmission of both parasites, affecting echinococcosis prevalence and human disease. Ecological environmental changes due to anthropogenic activities and natural events drive Echinococcus transmission and NHAR provides a notable example illustrating how human activity can impact on a parasitic infection of major public health significance. It is very important to continually monitor these environmental (including climatic factors that drive the distribution of Echinococcus spp. and their impact on transmission to humans because such information is necessary to formulate reliable future public health policy for echinococcosis control programs and to prevent disease spread.

  8. Study on the Coupling Process of Ecological Economic System of Desertification Control in the Ningxia Hui Autonomous Region%宁夏荒漠化治理生态经济系统耦合过程研究

    Institute of Scientific and Technical Information of China (English)

    朱海娟; 姚顺波

    2015-01-01

    通过建立生态社会经济综合评价指标体系和耦合模型,对宁夏地区实施荒漠化工程前后的耦合态势进行分析,研究表明,通过荒漠化治理工程的实施,宁夏地区的生态经济系统从消耗阶段发展到逐步协调的阶段,宁夏生态经济系统仍处于不断协调过程中,最后将形成良性的耦合态势。%By establishing eco -environmental and socio -economic comprehensive evaluation indices and coupling mode, the desertification control ecosystem’s coupling process in the Ningxia Hui was quantitatively evaluated.The results indica﹣ted the ecology -economic system in the Ningxia Hui had gone through the coupling processes of ecosystem system from e﹣conomic initial consumption to economic coordination.The current agriculture -ecology -economic system in the Ningxia Hui is still in the situation of coupling,and would have positive results eventually.

  9. Research on the evaluation method of rural hollowing based on RS and GIS technology: a case study of the Ningxia Hui autonomous region in China

    Science.gov (United States)

    Yin, Kai; Wen, MeiPing; Zhang, FeiFei; Yuan, Chao; Chen, Qiang; Zhang, Xiupeng

    2016-10-01

    With the acceleration of urbanization in China, most rural areas formed a widespread phenomenon, i.e., destitute village, labor population loss, land abandonment and rural hollowing. And it formed a unique hollow village problem in China finally. The governance of hollow village was the objective need of the development of economic and social development in rural area for Chinese government, and the research on the evaluation method of rural hollowing was the premise and basis of the hollow village governance. In this paper, several evaluation methods were used to evaluate the rural hollowing based on the survey data, land use data, social and economic development data. And these evaluation indexes were the transition of homesteads, the development intensity of rural residential areas, the per capita housing construction area, the residential population proportion in rural area, and the average annual electricity consumption, which can reflect the rural hollowing degree from the land, population, and economy point of view, respectively. After that, spatial analysis method of GIS was used to analyze the evaluation result for each index. Based on spatial raster data generated by Kriging interpolation, we carried out re-classification of all the results. Using the fuzzy clustering method, the rural hollowing degree in Ningxia area was reclassified based on the two spatial scales of county and village. The results showed that the rural hollowing pattern in the Ningxia Hui Autonomous Region had a spatial distribution characteristics that the rural hollowing degree was obvious high in the middle of the study area but was low around the study area. On a county scale, the specific performances of the serious rural hollowing were the higher degree of extensive land use, and the lower level of rural economic development and population transfer concentration. On a village scale, the main performances of the rural hollowing were the rural population loss and idle land. The

  10. Samen kom je er wel. Een afstudeerartikel over het Skejby halfway house: een huis waar delinquenten en studenten onder één dak wonen

    Directory of Open Access Journals (Sweden)

    Eline Broker

    2016-03-01

    Full Text Available Together you will get there. A graduation article on the Skejby halfway house: a house where delinquents and students live togetherThe Skejby house is unique and produces remarkable results. The recidivism percentage among its’ delinquent inhabitants is over 20% lower than in the halfway houses where only prisoners reside. The aim of Skejby is to ease the transition between imprisonment and reentry in society. The experiment, in which students and prisoners live together, originates from the idea that behavioral transformation is realized most effectively within a socially engaged group. The principal of collective responsibility is dominant in Skejby, resulting in a feeling of belonging to a group among the delinquents. In this group, the students serve as prosocial role models. Consequently, the standards and values that are picked up in prison are reshaped into much needed skills that are required for living a “regular” life in society. In contrast to the reintegration program in Skejby, the Dutch reintegration program mainly consists of one-to-one consultations between the delinquent and the probation officer. The reintegration thus does not take place in a group to which the delinquent can relate, while it is precisely this unique communal feeling of belonging that induces behavioral change in the prisoners. SAMENVATTING Samen kom je er wel. Een afstudeerartikel over het Skejby halfway house: een huis waar delinquenten en studenten onder één dak wonenHet Skejby house is uniek in zijn soort en boekt opmerkelijke resultaten: het recidivepercentage ligt ruim 20% lager dan bij halfway huizen waar alleen delinquenten wonen. Skejby heeft als doel om de overgang tussen gevangenis en samenleving zo klein mogelijk te maken. Het experiment, waarbij studenten en delinquenten samen wonen, komt voort uit het idee dat gedragsverandering het best bewerkstelligt wordt binnen een sociaal verbonden groep. In Skejby heerst het principe van

  11. Do generic utility measures capture what is important to the quality of life of people with multiple sclerosis?

    OpenAIRE

    Kuspinar, Ayse; Mayo, Nancy E

    2013-01-01

    Purpose The three most widely used utility measures are the Health Utilities Index Mark 2 and 3 (HUI2 and HUI3), the EuroQol-5D (EQ-5D) and the Short-Form-6D (SF-6D). In line with guidelines for economic evaluation from agencies such as the National Institute for Health and Clinical Excellence (NICE) and the Canadian Agency for Drugs and Technologies in Health (CADTH), these measures are currently being used to evaluate the cost-effectiveness of different interventions in MS. However, the cha...

  12. Comparison of direct and indirect methods of estimating health state utilities for resource allocation: review and empirical analysis.

    Science.gov (United States)

    Arnold, David; Girling, Alan; Stevens, Andrew; Lilford, Richard

    2009-07-22

    Utilities (values representing preferences) for healthcare priority setting are typically obtained indirectly by asking patients to fill in a quality of life questionnaire and then converting the results to a utility using population values. We compared such utilities with those obtained directly from patients or the public. Review of studies providing both a direct and indirect utility estimate. Papers reporting comparisons of utilities obtained directly (standard gamble or time tradeoff) or indirectly (European quality of life 5D [EQ-5D], short form 6D [SF-6D], or health utilities index [HUI]) from the same patient. PubMed and Tufts database of utilities. Sign test for paired comparisons between direct and indirect utilities; least squares regression to describe average relations between the different methods. Mean utility scores (or median if means unavailable) for each method, and differences in mean (median) scores between direct and indirect methods. We found 32 studies yielding 83 instances where direct and indirect methods could be compared for health states experienced by adults. The direct methods used were standard gamble in 57 cases and time trade off in 60(34 used both); the indirect methods were EQ-5D (67 cases), SF-6D (13), HUI-2 (5), and HUI-3 (37). Mean utility values were 0.81 (standard gamble) and 0.77 (time tradeoff) for the direct methods; for the indirect methods: 0.59(EQ-5D), 0.63 (SF-6D), 0.75 (HUI-2) and 0.68 (HUI-3). Direct methods of estimating utilities tend to result in higher health ratings than the more widely used indirect methods, and the difference can be substantial.Use of indirect methods could have important implications for decisions about resource allocation: for example, non-lifesaving treatments are relatively more favoured in comparison with lifesaving interventions than when using direct methods.

  13. The improvement and adaptation of the Hui nationality' s religion consciousness and social customs in the early Republic of China%民国初期回族宗教观念与社会习俗的改良与适应——以民国回族知识分子报刊文章为例

    Institute of Scientific and Technical Information of China (English)

    王晓霞

    2011-01-01

    民国初期的回族虽然在经济及社会发展方面仍在较低层次上徘徊,但在思想与文化方面却受到近世以来涌入中国的新思潮、新文化气象以及国内新文化运动的影响,出现了回族新文化运动的热潮,回族知识分子一方面以兴学校、办报刊觉醒民众,另一方面也对回族宗教与社会习俗进行反思与改革,要求回族在应对时代变化中实现自身的社会发展。宗教观念上大力提倡“理性”与“改良”意识,对一些闭塞与异化的宗教观念要求“正本清源”,力求“精义”;在回族社会生活习俗方面则更多地强调与新事物之间要“适应”与“协调”。%Although the Hui nationality' s social and economic development in the early Republic of China and is at a low level, their ideological and cultural are affected by the new ideas, the new culture atmosphere , the new culture movement pouring into modern China. The emergence of Hui nationality' s new culture movement appeared, the HUI intellectuals arouse people by establishing schools, publishing newspapers on one hand and ask the Hui nationality to realize the social self - development by reflecting and innovating from the social customs and the I-Iui nationality' s religious on the other. The consciousness of rationality and improvement are advocated in religious consciousness, and some closed and alienated religious consciousness has been reformed radically and aimed for essence. The adaptation and coordination for the new things are more emphasized in the Hui nationality' s social life and custom.

  14. Kalender uit Tweede Wereldoorlog kom huis toe

    African Journals Online (AJOL)

    Dit het higiene on- moontlik gemaak. As hulle voaraf geweet het dat hulle 'n maand daar sou deurbring, sou die mee- ste sekerlik al die eerste week omgekom het. Maar hulle het elke dag geglo dat hierdie mis- kien die laaste dag in die donker houthuis sou wees. En waar daar nog hoop is, is daar nog lewe. Altyd honger.

  15. Einstein today; Einstein aujourd'hui

    Energy Technology Data Exchange (ETDEWEB)

    Aspect, A.; Grangier, Ph. [Centre National de la Recherche Scientifique (CNRS), Lab. Charles Fabry de l' Institut d' Optique a Orsay, 91 - Orsay (France); Bouchet, F.R. [Institut d' Astrophysique de Paris, CNRS, 75 - Paris (France); Brunet, E.; Derrida, B. [Universite Pierre et Marie Curie, Ecole Normale Superieure, 75 - Paris (France); Cohen-Tannoudji, C. [Academie des Sciences, 75 - Paris (France); Dalibard, J.; Laloe, F. [Laboratoire Kastler Brossel. UMR 8552 (ENS, UPMC, CNRS), 75 - Paris (France); Damour, Th. [Institut des Hautes Etudes Scientifiques, 91 - Bures sur Yvette (France); Darrigol, O. [Centre National de la Recherche Scientifique (CNRS), Groupe Histoire des Sciences Rehseis, 75 - Paris (France); Pocholle, J.P. [Thales Research et Technology France, 91 - Palaiseau (France)

    2005-07-01

    The most important contributions of Einstein involve 5 fields of physics : the existence of quanta (light quanta, stimulated radiation emission and Bose-Einstein condensation), relativity, fluctuations (Brownian motion and thermodynamical fluctuations), the basis of quantum physics and cosmology (cosmological constant and the expansion of the universe). Diverse and renowned physicists have appreciated the development of modern physics from Einstein's ideas to the knowledge of today. This book is a collective book that gathers their work under 7 chapters: 1) 1905, a new beginning; 2) from the Einstein, Podolsky and Rosen's article to quantum information (cryptography and quantum computers); 3) the Bose-Einstein condensation in gases; 4) from stimulated emission to the today's lasers; 5) Brownian motion and the fluctuation-dissipation theory; 6) general relativity; and 7) cosmology. (A.C.)

  16. Slimmer netwerk gaat het huis uit

    NARCIS (Netherlands)

    Zevenbergen, R. van; Andel, T. van; Widlak, A.; Sigaloff, S.; Oeij, P.; Smout, J.; Stet, A.; Torre, W. van den; Popma, M.

    2015-01-01

    De afgelopen vier jaar hebben het minsterie van BZK, Kennisland, Kafkabrigade en TNO hard gewerkt aan Slimmernetwerk. Dit netwerk, van inmiddels ruim 4300 mensen op LinkedIn, was de thuisbasis voor een serie experimenten met ‘innovatie van onderop’ en interbestuurlijke samenwerking binnen de

  17. Variations autour de la tâche dans l'enseignement / apprentissage des langues aujourd'hui What kind of tasks are used for L2 teaching and learning today?

    Directory of Open Access Journals (Sweden)

    Elke Nissen

    2011-10-01

    Full Text Available Cet article se donne pour objectif d'identifier les types de tâches, et leurs dénominateurs communs, qui sont présentés aujourd'hui – où "l'approche par les tâches" est soutenue par le Conseil de l'Europe – aux apprenants. Il analyse pour cela les articles issus de deux numéros de revues et un ouvrage collectif récents. Il apparaît que la grande majorité des scénarios pédagogiques s'y inscrit dans la perspective actionnelle... du moins d'après la déclaration des auteurs, car leur définition de ce qu'est une tâche ne correspond pas toujours à celle du CECR. Pour le public visé, étudiants ou professionnels, on propose le plus souvent des mono-tâches, mais également des projets, ou encore des simulations avec un enchaînement de plusieurs tâches. Elles s'inscrivent généralement dans la (future réalité sociale des apprenants, mais certaines laissent également la place à des thèmes artistiques ou (interculturels. Contrairement à ce que l'on aurait pu attendre dans une démarche qui responsabilise l'apprenant, le recours à Internet n'est pas toujours systématique.At a time when action- and task-based learning is sustained by the European Council, this paper explores which types of tasks are given to second language learners today and what aspects these tasks have in common. The paper analyses two recent issues of scientific journals and one collective book. The analysis shows that the majority of pedagogical scenarios described in these texts claim to adopt an action- and task-based approach. However, in reality the way they define a task does not always correspond to the definition given by the European Framework of Reference for Languages. The described tasks are exclusively dedicated to higher and professional education; they are mostly single tasks, but they can also be projects and simulations including several successive tasks. They generally correspond to the learners' (future reality, with themes that are

  18. The impact of age-related macular degeneration on health status utility values.

    Science.gov (United States)

    Espallargues, Mireia; Czoski-Murray, Carolyn J; Bansback, Nicholas J; Carlton, Jill; Lewis, Grace M; Hughes, Lindsey A; Brand, Christopher S; Brazier, John E

    2005-11-01

    To estimate health status utility values in patients with age-related macular degeneration (ARMD) associated with visual impairments, by using preference-based measures of health. This was a cross-sectional study involving patients with unilateral or bilateral ARMD who attended a large teaching hospital. Patients underwent visual tests (near and distant visual acuity [VA] and contrast sensitivity [CS]) and completed health status questionnaires including the Index of Visual Function (VF)-14 and three preference-based measures (the Health Utilities Index Mark III [HUI-3], the EuroQoL Health Questionnaire [EQ-5D], and the Short Form 6D Health Status Questionnaire [SF-6D]) and the time tradeoff (TTO). The mean health status is presented for five groups, defined according to the VA in the better-seeing eye and for four CS groups. Two hundred nine patients were recruited with substantial loss of visual function as obtained by visual tests (mean decimal VA in the better-seeing eye: 0.2) and self-report (mean VF-14 score: 41.5). The mean (+/-SD) utilities were 0.34 +/- 0.28 for HUI-3, 0.66 +/- 0.14 for SF-6D, 0.72 +/- 0.22 for EQ-5D, and 0.64 +/- 0.31 for TTO. The HUI-3 had the highest correlation with VA and CS (0.40 and -0.34), followed by TTO (0.25 and -0.21). Across the VA and CS groups, only HUI3 and TTO had a significant linear trend (P preference-based measures used. The HUI-3 seems to be the instrument of choice for use in economic evaluations in which community data are needed. It may be more appropriate to base economic models on CS or some combination of CS and VA rather than on VA alone.

  19. Cost-effectiveness analysis of cochlear dose reduction by proton beam therapy for medulloblastoma in childhood

    International Nuclear Information System (INIS)

    Hirano, Emi; Kawabuchi, Koichi; Fuji, Hiroshi; Onoe, Tsuyoshi; Kumar, Vinay; Shirato, Hiroki

    2014-01-01

    The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after treatment with proton or X-ray radiotherapy. The risks of hearing loss were calculated on cochlear dose for each treatment. Three types of health-related quality of life (HRQOL) of EQ-5D, HUI3 and SF-6D were used for estimation of quality-adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) for proton beam therapy compared with X-ray radiotherapy was calculated for each HRQOL. Sensitivity analyses were performed to model uncertainty in these parameters. The ICER for EQ-5D, HUI3 and SF-6D were $21 716/QALY, $11 773/QALY, and $20 150/QALY, respectively. One-way sensitivity analyses found that the results were sensitive to discount rate, the risk of hearing loss after proton therapy, and costs of proton irradiation. Cost-effectiveness acceptability curve analysis revealed a 99% probability of proton therapy being cost effective at a societal willingness-to-pay value. Proton beam therapy with cochlear dose reduction improves health outcomes at a cost that is within the acceptable cost-effectiveness range from the payer's standpoint. (author)

  20. Do generic utility measures capture what is important to the quality of life of people with multiple sclerosis?

    Science.gov (United States)

    Kuspinar, Ayse; Mayo, Nancy E

    2013-04-25

    The three most widely used utility measures are the Health Utilities Index Mark 2 and 3 (HUI2 and HUI3), the EuroQol-5D (EQ-5D) and the Short-Form-6D (SF-6D). In line with guidelines for economic evaluation from agencies such as the National Institute for Health and Clinical Excellence (NICE) and the Canadian Agency for Drugs and Technologies in Health (CADTH), these measures are currently being used to evaluate the cost-effectiveness of different interventions in MS. However, the challenge of using such measures in people with a specific health condition, such as MS, is that they may not capture all of the domains that are impacted upon by the condition. If important domains are missing from the generic measures, the value derived will be higher than the real impact creating invalid comparisons across interventions and populations. Therefore, the objective of this study is to estimate the extent to which generic utility measures capture important domains that are affected by MS. The available study population consisted of men and women who had been registered after 1994 in three participating MS clinics in Greater Montreal, Quebec, Canada. Subjects were first interviewed on an individualized measure of quality of life (QOL) called the Patient Generated Index (PGI). The domains identified with the PGI were then classified and grouped together using the World Health Organization's International Classification of Functioning, Disability and Health (ICF), and mapped onto the HUI2, HUI3, EQ-5D and SF-6D. A total of 185 persons with MS were interviewed on the PGI. The sample was relatively young (mean age 43) and predominantly female. Both men and women had mild disability with a median Expanded Disability Status Scale (EDSS) score of 2. The top 10 domains that patients identified to be the most affected by their MS were, work (62%), fatigue (48%), sports (39%), social life (28%), relationships (23%), walking/mobility (22%), cognition (21%), balance (14%), housework (12

  1. Vreugde en verdriet in die huis van Jakob

    Directory of Open Access Journals (Sweden)

    Paul Krueger

    2008-01-01

    Full Text Available Happiness and lament in the house of Jacob The birth narrative in Genesis 29:31-30:24 is a coherent mini drama in its own right, although it is embedded in the patriarchal narratives and as such furnishes important background to the unfolding drama in Jacob's house. In this narrative, the reader is invited right into the intricate family relations of a dysfunctional polygamous marriage, where two rivals communicate with each other and their mutual husband by means of the names given at birth to their children and the children of their slave girls. This article focuses on the quest for happiness, which is evident in the births and name-giving in the house of Jacob. Although true happiness remains elusive, at the end both women receive their dues. God keeps a balance between the two contenders, but the birth of Rachel’s son calls for a resolution still to come. The text is thus left open ended.

  2. Vreugde en verdriet in die huis van Jakob

    African Journals Online (AJOL)

    p1243322

    the children of their slave girls. This article focuses on the quest for happiness, which is evident in the births and name-giving in the house of Jacob. Although true happiness remains elusive, at the end both women receive their dues. God keeps a balance between the two contenders, but the birth of Rachel's son calls for a.

  3. [Study on baking processing technology of hui medicine Aconitum flavum].

    Science.gov (United States)

    Fu, Xue-yan; Zhang, Bai-tong; Li, Ting-ting; Dong, Lin; Hao, Wen-jing; Yu, Liang

    2013-12-01

    To screen and optimize the processing technology of Aconitum flavum. The acute-toxicity, anti-inflammatory and analgesic experiments were used as indexes. Four processing methods, including decoction, streaming, baking and processing with Chebulae Fructus decoction, were compared to screen the optimum processing method for Aconitum flavum. The baking time was also optimized. The optimal baked technology was that 1-2 mm decoction pieces was baked at 105 degrees C for 3 hours. The baking method is proved to be the optimal processing method of Aconitum flavum. It is shown that this method is simple and stable.

  4. L'université aujourd'hui | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC at the World Conference of Science Journalists 2017. The 2017 World Conference of Science Journalists was an opportunity for the awardees to develop their skills and network with some of the most influential science journalists in the world. View moreIDRC at the World Conference of Science Journalists 2017.

  5. Art d’aujourd’hui – Patrimoine de demain

    Directory of Open Access Journals (Sweden)

    Marcel Stefanaggi

    2008-10-01

    Full Text Available C’est à Paris, à l’Institut National du Patrimoine (INP, et en partenariat avec cette Institution que se tiendront les 24-26 juin 2009 les 13e journées d’études de la SFIIC, sur le thème de la Conservation et restauration des œuvres contemporaines.PrésentationLes œuvres contemporaines présentent des caractères spécifiques, et ne peuvent pas être traitées comme des œuvres d’art « classiques » : leur finalité, souvent différente, les matériaux utilisés, étroitement liés à leur époque, l’utilis...

  6. Terrorisme maritime et piraterie d’aujourd’hui

    Directory of Open Access Journals (Sweden)

    Hugues Eudeline

    2009-09-01

    Full Text Available Hors temps de conflits armés, les actes de violence dans le domaine maritime sont essentiellement de deux sortes : la piraterie, pratiquée à des fins privées, et le terrorisme qui poursuit des objectifs politiques. Répondant à des logiques différentes, ces deux formes de violence constituent, indépendamment, des menaces pour les 50 000 navires marchands qui transportent plus de 90% du commerce mondial. Leur éventuelle collusion, si elle était de grande ampleur, pourrait avoir un effet multiplicateur entraînant des conséquences très importantes sur une économie mondiale fragilisée.L’environnement physique qu’elles partagent est propice aux activités illégales. La mer couvre 71% de la surface du globe et constitue un espace pour l’essentiel libre de toute emprise étatique et impossible à contrôler. Les nombreuses actions des pirates autour de l’Afrique malgré les réactions internationales le montrent à l’envi. En parallèle, la mouvance terrorisme islamiste développe une stratégie d’attaque de l’économie mondiale dont les flux maritimes constituent un des principaux piliers.Les liens des deux activités avec la criminalité les rapprochent également. Le terrorisme les entretient pour des raisons logistiques et financières, alors que la piraterie, avec les différents trafics, en est une composante maritime majeure.Cette proximité et une complémentarité des compétences nécessaires à leur pratique pourraient les rapprocher plus encore. Cette entente contre-nature permettrait d’associer les connaissances nautiques des pirates, marins expérimentés aux capacités de planification des terroristes.Apart from times of high intensity conflict, the two main forms of violence at sea are piracy, and maritime terrorism. If the former is perpetrated at private ends, the latter is politically motivated. Although addressing different ends, both activities are important threats for the 50,000 merchant vessels sailing the oceans and moving 90% of our world’s commerce. A piracy-terrorism nexus, if widely spread, could have lethal consequences for a weakened world economyBoth of them share a physical environment favorable to illegal activities. The oceans covering nearly three-quarters of the planet, freedom of the high seas make them impossible to control. Enduring piracy activities around Africa displays it at will. In parallel, Islamist terrorism implements its strategy targeting the world economy of which sea trade is one of the main pillars. Both activities are also closely linked to criminal activities: Terrorism for logistic purposes, while piracy is one of its main maritime components. Recognizing the close relationship between both activities, along with the complementarities of some specific skills could bring them even closer. Such an unnatural alliance could bring together the seamanship of pirates with the planning expertise of highly motivated terrorists.

  7. Improvement of universal salt iodization program on the intelligence quotient among children in Linxia Hui Autonomous Prefecture of Gansu%甘肃省临夏回族自治州2006年和2010年食盐加碘改善儿童智力评估

    Institute of Scientific and Technical Information of China (English)

    曹永琴; 王燕玲; 朱小南; 窦瑜贵; 李洪波; 孙玮; 郑菁

    2012-01-01

    Objective To assess the improvement of intelligence quotient through an Universal Salt Iodization Supply Program,among children.Methods 3518 and 1611 children were selected from primary schools in Linxia Hui Autonomous Prefecture of Gansu in 2006 and 2010respectively.Intelligence quotient (IQ) were measured by the revised Chinese Combined Raven Test C2 (CRT-C2).Results In 2006,the average IQ of children aged 8-10 was 85.1,including 16.7% of them with IQ≤69.The average IQ was between 80-90 in different counties and cities,with significant differences (P<0.05).The average IQs were 92.0,90.6 and 81.8 among 8,9 and 10 years old children respectively with 10 year old' s low than those 8 and 9 year olds (P<0.05).The average IQs of boys and girls were 84.5 and 85.6,but with no significant difference (P >0.05).The average IQ of children aged 8-10 in 2010 was 97.2 and 12 points higher than in 2006 (P<0.05),but 8 IQ points (P<0.05) less than the average level 105 from the overall of Gansu province.4.7% of the children having an IQ≤69.IQ of children from Linxia city and Yongjing county,were up to the theoretical level of 100,with an average IQ at around 95 in other counties.The average IQs between counties or cities showed significant differences.The IQ of 8,9 year olds and 10 year olds did not present significant difference (P>0.05),but in boys (98.8) and in girls (95.9) the difference was significant (P<0.05).Conclusion The average IQ was close to the theoretical level (100) with the gradual implementation of universal salt iodization program,showing that the iodized salt did play a key role on children's intelligence.However,the average IQ was still lower than the average level of the whole Gansu province in 2010.%目的 评估食盐加碘对学龄儿童的智力改善情况.方法 2006年和2010年均采用中国联合型瑞文测验第二次修订版(CRT-C2)对甘肃省临夏回族自治州(临夏州)8个县(市)3518名和1611名8~10岁

  8. 社会-生态系统视角下沙漠化逆转定量评价——以宁夏盐池县为例%Quantitative evaluation of desertification restoration based on the social-ecological system: A case study in Yanchi, Ningxia Hui Autonomous Region

    Institute of Scientific and Technical Information of China (English)

    侯彩霞; 周立华; 文岩; 赵敏敏; 陈勇

    2017-01-01

    The assessment of socio-ecological systems can reflect the effects of nature,social economics,and human activities on the ecological environment,which is helpful to understand the context of complex social-ecological systems.Desert areas are ideal for socio-ecological system assessments because the land cover of deserts seriously influences the improvement of the local ecological environment and social economy.Yanchi County in the Ningxia Hui Autonomous Region is a typical desertification area where the ecological environment is very fragile.The government has implemented the Grain for Green Project and a prohibited-grazing policy to suppress and reverse desertification since 2000,and these ecological policies have positive effects on ecological restoration of desert areas.Therefore,it is very important to control desertification and maintain the normal function of local social-ecological systems.In this paper,the social-ecological system disturbance in Yanchi County was analyzed to understand the changes of the local social-ecological system.The MODIS (Moderate resolution Imaging Spectrometer) normalized difference vegetation index (NDVI) data of the study region was applied to investigate the spatial distribution of the existing social-ecological system disturbance during 2000-2015.In addition,moving window computational algorithms were used to calculate social-ecological system disturbance intensity and connectivity at different spatial scales.The results showed that (1) the disturbance had different spatial distributions over different periods,and strong disturbances were mainly distributed in southern Yanchi County during 2000-2004,whereas strong disturbances were distributed in the northern and central areas during 2004-2008.Furthermore,strong disturbances were detected in three small areas:southeastern,central,and western Yanchi County during 2008-2012.Moreover,the proportion of strong disturbances in the North showed an increasing trend.Strong disturbances

  9. Common generic measures of health related quality of life in injured patients.

    Science.gov (United States)

    Shearer, David; Morshed, Saam

    2011-03-01

    The measurement of health-related quality of life (HRQOL) through generic outcome instruments is important for comparisons of populations across disease states and interventions. The growing number of questionnaires available has made selection and interpretation more difficult. Profile instruments such as the SF-36 and Sickness Impact Profile provide insight into various domains of health with established population norms. Preference-based measures, including the EQ-5D, Health Utilities Index, SF-6D, and QWB-SA are used to generate utility scores, which can be used for cost-effectiveness analysis and therefore have particular relevance in health policy. Both types of generic measures have been used in clinical trials in injured populations to assess the relative impact of interventions on quality-of-life. Comparisons of internal consistency and test-retest reliability across measures reveal minimal differences between instruments, and reported values are acceptable for group comparisons but insufficient for individual clinical use. There is a dearth of studies evaluating the validity of these measures in the trauma population, but available data suggest most of the available instruments are acceptable. Populations that may require special consideration are patients with head, spinal cord, and upper-extremity injuries. Practical issues to consider in selecting a questionnaire include time for completion, which ranges from less than 2 min for the EQ-5D to 20-30 min for the Sickness Impact Profile. Selection of the appropriate measure ultimately depends largely on the population to be studied and whether utility-estimation is desired. Copyright © 2010 Elsevier Ltd. All rights reserved.

  10. Comment peut-on lire Ivan Hadjiiski aujourd’hui ?

    Directory of Open Access Journals (Sweden)

    Svetla Koleva

    2010-06-01

    Full Text Available Présentation de deux textes d’Ivan Hadjiiski (1907-1944 : « Les racines historiques de nos traditions démocratiques » paru pour la première fois dans la Revue Philosophique/Filossofski pregled, 1937, 9/1 ; et « Traits atypiques du développement de notre société », paru dans Problèmes sociologiques/Sotziologitcheski problemi, 1986, n° 3, et publiés ici avec l’autorisation des tenants des droits d’auteur.How to read Ivan Hadjiiski today? Introduction to two Ivan Hajiisji’s textsPresentation of Ivan Hadjiiski’s two texts:"Historical roots of our democratic traditions", first published in Philosophical Journal/Filossofski pregled, 1937, 9/1, and "Atypical features of our society’s development" first published in Sociological Problems/Sotziologitcheski problemi, 1986, n° 3, which are published here with the kind authorization of copyright owners.¿Como se puede leer hoy Ivan Hadjiiski?Introducción y análisis de dos textos de Ivan Hadjiiski: "Las raíces históricas de nuestras tradiciones democráticas", publicado por primera vez en EstudioFilosófico/Filossofski pregled, 1937, 9/1, y "Aspectos inhabituales del desarrollo de la sociedad actual" publicado por primera vez en Problemas sociológicos/Sotziologitcheski problemi, 1986, n° 3, y aquí publicados con la amable autorización de los teniendos de los derechos de autor.

  11. Jane Eyre, Past and Present Jane Eyre, d’hier à aujourd’hui

    Directory of Open Access Journals (Sweden)

    Armelle Parey

    2009-10-01

    Full Text Available The present collection of articles along with a few additional contributions contains the proceedings of a conference held at the university of Caen Basse-Normandie, France in May 2004. Entitled “Jane Eyre, Past and Present”, its aim was to study the posterity of Charlotte Brontë’s novel and/or character since its publication in 1847. That two-thirds of the texts studied in this volume were published in the last decade of the twentieth century attests to the fact that rewriting has become a m...

  12. Infinite Dimensional Stochastic Analysis : in Honor of Hui-Hsiung Kuo

    CERN Document Server

    Sundar, Pushpa

    2008-01-01

    This volume contains current work at the frontiers of research in infinite dimensional stochastic analysis. It presents a carefully chosen collection of articles by experts to highlight the latest developments in white noise theory, infinite dimensional transforms, quantum probability, stochastic partial differential equations, and applications to mathematical finance. Included in this volume are expository papers which will help increase communication between researchers working in these areas. The tools and techniques presented here will be of great value to research mathematicians, graduate

  13. Gas market is today strategical; Le marche du gaz est aujourd'hui strategique

    Energy Technology Data Exchange (ETDEWEB)

    Darricarrere, Y.L. [Total, 92 - Courbevoie (France)

    2006-07-01

    The energy market, and in particular the gas market, is today seething with excitement. In France, in Europe and in the rest of the world, the energy stakes are in the center of preoccupations. This article is an interview of Y.L. Darricarrere, general director of the gas and electricity division of Total group, who explains his opinions about the opening of European and French energy markets, presents the ambitions of Total group on these markets, and comments some recent events of the European energy scene: concentration between gas and electric utilities, the Suez and Gaz de France (GdF) project of merger, the risks linked with the coming in of national companies from producing countries, like Gazprom and Sonatrach, on the European market, the restriction of access of foreign companies to hydrocarbon reserves in Russia and Latin America (come back of the 'energy nationalism'), Total's policy for anticipating the increase of the world energy demand and the depletion of fossil fuel reserves. (J.S.)

  14. Hui et al., Afr J Tradit Complement Altern Med. (2015) 12(2):103-113 ...

    African Journals Online (AJOL)

    Proff.Adewunmi

    ingredients of many formulations in Chinese medicine for the treatment of toothache. ... human premolars under various treatments including the desensitizing gel. ... Hypersensitive teeth has highly obviously increased numbers of tubules per ...

  15. Als de kat van huis is ... : zwerfkatten in Nederland: een inventarisatie

    NARCIS (Netherlands)

    Neijenhuis, F.; Niekerk, van T.G.C.M.

    2015-01-01

    Het doel van dit Wageningen UR Wetenschapswinkel-project is het inventariseren van de omvang van het zwerfkattenprobleem in Nederland, de karakteristieken van de problematiek, de betrokken stakeholders en de mogelijkheden voor aanpak van het zwerfkattenprobleem. Dit onderzoek is in opdracht van

  16. L'université aujourd'hui | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Depuis ses origines médiévales à nos jours, l'Université a joué un rôle important dans le développement et la transmission du savoir. Mais à la fin du XXe siècle, après 40 années d'expansion ininterrompue, l'institution de haut savoir subit partout des contraintes financières.

  17. China's Rangelands under Stress : A comparative study of pasture commons in the Ningxia Hui Autonomous Region

    NARCIS (Netherlands)

    Ho, P.P.S.

    2000-01-01

    China's economic reforms have exacerbated the problems of over-grazing and desertification in the country's pastoral areas. In order to deal with rangeland degradation, the Chinese government has resorted to nationalization, or semi-privatization. Since the implementation of rangeland policy has

  18. Astronomie spatiale infrarouge, aujourd’hui et demain = Infrared space astronomy, today and tomorrow

    CERN Document Server

    Lequeux, J; David, F

    2000-01-01

    This book brings together the lectures given at the Les Houches summer school "Infrared space astronomy, today and tomorrow". It gives a wide overview of infrared astronomy, a wavelength domain crucial for studies of the solar system, stars at the beginning and end of their lives, interstellar matter and galaxies at all distances. Recent developments in observational techniques have been tremendous. The first contributions give an introduction to the basic physical processes and methods of detection and data processing. They are followed by a series of lectures dealing with the wide variety of astronomical objects that can be seen in the infrared.

  19. Art d’aujourd’hui, patrimoine de demain. Conservation et restauration des œuvres contemporaines

    Directory of Open Access Journals (Sweden)

    Muriel Verbeeck-Boutin

    2009-10-01

    Full Text Available Paru, et c’est un tour de force, dans le temps même où débutait le colloque du même nom,  l’ouvrage met à disposition le texte des trente-neuf communications présentées à cette occasion. Les trois journées étaient consacrées à des thématiques diverses, illustrées par des orateurs venus de tous les horizons. La richesse des interventions et leur nombre ne nous permettront pas de nous arrêter à leur détail, et nous proposons ici une introduction, ainsi qu’un bref retour sur les échanges et disc...

  20. Het huis van ik : ideologie en theorie in het Nederlandse vormgevingsonderwijs

    NARCIS (Netherlands)

    Eijnde, Jeroen Nicolaas Maria van den

    2015-01-01

    The House of I. Ideology and Theory in the Netherlands' Design Education is based on the hypothesis that Dutch Art Academies, which since the emergence of (applied) art education have focused expressly on training the professional artist type - in stead of a focus on the dependent artist type (the

  1. Hui et al., Afr J Tradit Complement Altern Med. (2015) 12(2):103-113 ...

    African Journals Online (AJOL)

    Proff.Adewunmi

    Keywords: Traditional Chinese medicine; Bamboo salt; Dentin hypersensitivity; Thermosensitive gel; Scanning electron microscopy; Clinical trials .... (2013) in their double-blind randomized controlled trial to determine the effectiveness of a prophylaxis paste. ..... Mechanism of the phenomenon needed further research.

  2. Étudier la science-fiction en France aujourd’hui

    Directory of Open Access Journals (Sweden)

    Irène Langlet

    2012-10-01

    Full Text Available La science-fiction est une pratique intermédiatique reconnue dans la culture contemporaine mais discrète dans le monde universitaire. Ce contraste s’explique par l’histoire du genre et sa constitution progressive, dans notre pays, en « paralittérature », voire en « subculture ». Mais la situation évolue, grâce à des pratiques académiques en pleine recomposition disciplinaire, ainsi renouvellement des générations accentuant la porosité des barrières culturelles. Les perspectives qui peuvent en être tirées se déduisent de ce paysage complexe.

  3. Pascal (Yang Hui) triangles and power laws in the logistic map

    International Nuclear Information System (INIS)

    Velarde, Carlos; Robledo, Alberto

    2015-01-01

    We point out the joint occurrence of Pascal triangle patterns and power-law scaling in the standard logistic map, or more generally, in unimodal maps. It is known that these features are present in its two types of bifurcation cascades: period and chaotic-band doubling of attractors. Approximate Pascal triangles are exhibited by the sets of lengths of supercycle diameters and by the sets of widths of opening bands. Additionally, power-law scaling manifests along periodic attractor supercycle positions and chaotic band splitting points. Consequently, the attractor at the mutual accumulation point of the doubling cascades, the onset of chaos, displays both Gaussian and power-law distributions. Their combined existence implies both ordinary and exceptional statistical-mechanical descriptions of dynamical properties. (paper)

  4. Le probleme des valeurs a l'ecole française aujourd'hui

    Science.gov (United States)

    Legrand, Louis

    1995-01-01

    Since the 1960s the French public school system has virtually abandoned the attempt to teach moral values, leaving students morally disoriented. The author finds this situation profoundly unhealthy and argues that schools have a responsibility to help in developing the ability of pupils to make moral choices and act accordingly. He rejects the rationalist view that science makes traditional morality unnecessary. At the same time, he recognizes the moral value of the scientific respect of truth and objectivity. He argues for a form of moral education which would inculcate respect for different points of view, cultural norms and religious beliefs, and which would not shy away from addressing morally important issues such as drag abuse, violence, sexuality, social justice, poverty, racism and environmental pollution.

  5. Erratum to: Interpersonal discrimination and health-related quality of life among black and white men and women in the United States.

    Science.gov (United States)

    Sellers, Sherrill L; Cherepanov, Dasha; Hanmer, Janel; Fryback, Dennis G; Palta, Mari

    2013-08-01

    We assessed associations between discrimination and health-related quality of life among black and white men and women in the United States. We examined data from the National Health Measurement Study, a nationally representative sample of 3,648 adults aged 35-89 in the non-institutionalized US population. These data include self-reported lifetime and everyday discrimination as well as several health utility indexes (EQ-5D, HUI3, and SF-6D). Multiple regression was used to compute mean health utility scores adjusted for age, income, education, and chronic diseases for each race-by-gender subgroup. Black men and women reported more discrimination than white men and women. Health utility tended to be worse as reported discrimination increased. With a few exceptions, differences between mean health utility scores in the lowest and highest discrimination groups exceeded the 0.03 difference generally considered to be a clinically significant difference. Persons who experienced discrimination tended to score lower on health utility measures. The study also revealed a complex relationship between experiences of discrimination and race and gender. Because of these differential social and demographic relationships caution is urged when interpreting self-rated health measures in research, clinical, and policy settings.

  6. Interpersonal discrimination and health-related quality of life among black and white men and women in the United States.

    Science.gov (United States)

    Sellers, Sherrill; Cherepanav, Dasha; Hanmer, Janel; Fryback, Dennis G; Palta, Mari

    2013-08-01

    We assessed associations between discrimination and health-related quality of life among black and white men and women in the United States. We examined data from the National Health Measurement Study, a nationally representative sample of 3,648 adults aged 35-89 in the non-institutionalized US population. These data include self-reported lifetime and everyday discrimination as well as several health utility indexes (EQ-5D, HUI3, and SF-6D). Multiple regression was used to compute mean health utility scores adjusted for age, income, education, and chronic diseases for each race-by-gender subgroup. Black men and women reported more discrimination compared to white men and women. Health utility tended to be worse as reported discrimination increased. With a few exceptions, differences between mean health utility scores in the lowest and highest discrimination groups exceeded the 0.03 difference generally considered to be a clinically significant difference. Persons who experienced discrimination tended to score lower on health utility measures. The study also revealed a complex relationship between experiences of discrimination and race and gender. Because of these differential social and demographic relationships caution is urged when interpreting self-rated health measures in research, clinical, and policy settings.

  7. Penser les Balkans aujourd'hui : l’orientalisme, le balkanisme, et la question de la modernité

    Directory of Open Access Journals (Sweden)

    Vladimir Milisavljević

    2009-12-01

    Full Text Available This paper aims at investigating the positions of the Balkans in ourcontemporary world in its continuous change – for instance the rapidEuropeanization for the protection of a common inheritance of Balkancountries. Moreover, this historical heritage is sometimes presented as a simple burden that should be overcome: the name Balkan has negative connotations, being associated with violence or primitivism. The criticism of this type of derogatory discourse called « Balkanism » is built on the deconstruction of Orientalism as initiated in the 70’s by Edward Said. In this paper, we will analyze the various types of possible objections to this Balkan approach (the absence of a colonial past, the non-existence of a « Balkan » academic tradition, the Balkan preciseness as opposed to the Oriental vagueness, as well as their not purely « oriental », yet undetermined character. Furthermore I will present the arguments in favour of another way of interpreting the Balkans which consists in the understanding of thenarrower relation between European modernity and history.

  8. Europinė semiotika šiandien | Sémiotique européenne d’aujourd’hui

    Directory of Open Access Journals (Sweden)

    Kęstutis Nastopka

    2004-01-01

    Full Text Available Dans le champ sémiotique, deux approches épistémologiques se distinguent : sémiotique européenne et sémiotique américaine. La sémiotique européenne, issue de la théorie du signe linguistique de Ferdinand de Saussure, dans les années 1960 voit se former deux écoles indépendantes : celle de Paris (de Greimas et celle de Tartou-Moscou (de Lotman.La sémiotique dite « standard » de Greimas présente une théorie du discours envisagé comme un tout de signification. En comprenant la signification comme un processus, Greimas décrit les transformations des significations d’après le modèle du discours mythique élaboré par Vladimir Propp. Le monde est traité comme discontinu et composé d’oppositions. Dans les années 1980 l’école greimassienne passe de la sémiotique de faire à celle d’état, de la discontinuité à la continuité, de l’objet au sujet, de l’énoncé à l’énonciation. Dans la sémiotique des passions au centre du programme narratif se trouve une compétence modale du sujet. Ces derniers temps, parmi les héritiers de Greimas, à côté de la sémiotique tensive qui choisit un métalangage savant et des schématisations un peu arides, apparaît une sémiotique esthésique, issue de De l’imperfection de Greimas.Le concept de systèmes modelants secondaires est devenu une sorte d’emblème de l’école de Tartou. Ce terme détermine des structures communicatives différentes, organisées d’après le modèle des signes linguistiques. A la recherche d’un métalangage scientifique, commun aux diverses disciplines humaines, on s’oriente vers la linguistique structurale et la théorie de l’information. Autour de l’année 1980, dans la sémiotique de Lotman la conception du texte commeune manifestation de la langue est changée par celle du texte qui produit sa propre langue. Le texte est considéré non plus comme un systéme autonome, synchronique mais comme un énoncé, inséparable de la mémoire d’énonciation. De la description des systèmes modelants secondaires on se tourne vers la sémiotique de culture. Le bornage des frontières et la discontinuité sont traités comme des éléments essentiels de la sémiosphère, c’est-à-dire, de l’espace où se réalise la sémiosis.Dans l’article, c’est le choix épistémologique qui est considéré comme une pierre d’achoppement d’un accord entre la sémiotique européenne et celle américaine. Les uns comprennent la signification comme une certaine structure mentale (signifié ou comme un ensemble des traits sémantiques (intension, les autres la conçoivent comme un référent non-linguistique ou comme un ensemble des objets du monde extérieur (extension. La brèche entre l’intension et l’extension peut être remplie par l’instance de l’énonciation. Entre la perception et la signification s’intercale le langage comme une visée intentionnelle du monde. En examinant le rapport entre deux sémiotiques on a recours à l’ouvrage d’Umberto Eco Kant et l’ornithorynque et au roman Le secret du professeur Amfortas d’Eero Tarasti.

  9. L’insularité aujourd’hui : entre mythes et réalités

    Directory of Open Access Journals (Sweden)

    Thierry Nicolas

    2008-02-01

    Full Text Available De nombreuses études, dans des domaines variés (économie, statistiques, géographie…, s’attachent en effet à saisir les contraintes que fait peser la géographie sur la réussite économique des îles. Pour la plupart d’entre elles, l’insularité se présente comme une donnée négative qui génère une série de handicaps difficilement surmontables (exiguïté du territoire, faible peuplement, surcoûts, etc.. Cependant les perspectives de développement de ces territoires isolés en permanence par la mer, dotés de possibilités réduites en termes d’espace, de ressources naturelles ou humaines, ou de taille de marché, ne sont pas systématiquement vouées à l’échec.Numerous studies in various fields (economics, statistics, geography, etc., have attempted to define  the constraints posed by geographic reality on the economic success of the islands. For the most part , these studies present insularity as a handicap difficult to overcome  (limited territorial extent, sparse population, higher costs, etc.. Nevertheless the development prospects of these territories permanently isolated by the sea, with reduced opportunities in terms of space, natural resources or human, or market size, are not necessarily doomed to failure

  10. Think the future to act now; Penser l'avenir pour agir aujourd'hui

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The object of the club 'Energy, prospective and discussions', created in september 1998, is to provide the continuity of the engaged works in the commission 'Energy 2010-2020' and to understand the ideas evolution. The technical progress, the institutions, the shock of the societies and the cultures, of the nature, the world-wide, lead every day to forecasting, which are guidelines for the public decisions, more and more risky. This complexity analysis is needed for a long-dated energy policy. Thus the club analysed and compared the long-dated and international scenario; made the transfer of the information on the development concerning the energy and the environment; defined subjects of discussion; begun and managed scientific studies. This progress report presents the proceedings of the first year of the club. (A.L.B.)

  11. [Systematic review of health-related utilities in Spain: the case of mental health].

    Science.gov (United States)

    García-Pérez, Lidia; Aguiar-Ibáñez, Raquel; Pinilla-Domínguez, Pilar; Arvelo-Martín, Alejandro; Linertová, Renata; Rivero-Santana, Amado

    2014-01-01

    Currently, there is no registry of utility values for the Spanish population that could potentially be used in economic evaluations. Consequently, a systematic review of utilities or preferences for health states in the Spanish population was conducted. The results related to mental health are reported. A systematic review of the literature was conducted. The main databases searched were MEDLINE, CRD, Embase, PsycINFO, CINAHL, and Cochrane. The search strategy combined terms related to utilities and Spain. The inclusion criteria comprised the resident population in Spain, whether affected by any disease or not; the reported utilities had to be evaluated through a tool validated in Spain (i.e., EQ-5D, HUI, SF-6D) and/or following accepted techniques (e.g., time trade-off, standard gamble, or the visual analog scale). A narrative synthesis of articles was undertaken and the results related to mental health summarized. A total of 103 articles were finally included, from which 742 utility values were extracted. Sixty-nine utility values related to mental health and behavioral disorders were extracted from 12 studies. The most widely used tool was the E5-QD questionnaire. Most of the excluded articles evaluated quality of life but did not provide an estimation of utilities. This review adds value to research on utilities in Spain by gathering values to be included in economic evaluations, as well as by identifying research gaps in this field. The utility values related to mental health identified in this study are similar to those reported in international publications. Copyright © 2013 SESPAS. Published by Elsevier Espana. All rights reserved.

  12. Ancient engineering geology projects in China; A canal system in Ganzu province and trenches along the Great Wall in Ningxia Hui Autonomous Region

    Science.gov (United States)

    Wallace, R.E.; Bucknam, R.C.; Hanks, T.C.

    1994-01-01

    Two major construction projects of ancient times in China involved what today would be considered engineering geology. We describe an ancient canal system in Gaotai County, Gansu province that was possibly begun in the Han dynasty (206 BC-220 AD). The canal system heads at the Dasha River and extends northwestward for about 55 km to the City of Camels and Xusanwan village. Four parallel canals are present at the local site we examined. The canals were likely built primarily to transport water but may also have served as defensive military barriers. A second project involves trenches and berms along the north side of the Great Wall, clearly part of the Great Wall defensive system. This site is in Ningxia Autonomous Region near the town of Shizuishan. ?? 1994.

  13. Association of CYP1B1 Polymorphisms with Breast Cancer: A Case-Control Study in the Han Population in Ningxia Hui Autonomous Region, P. R. China

    Science.gov (United States)

    Jiao, Haiyan; Liu, Chunlian; Guo, Weidong; Peng, Liang; Chen, Yintao; Martin, Francis L.

    2010-01-01

    Studies investigating possible associations between cytochrome P4501B1 (CYP1B1) polymorphisms and breast cancer risk have been inconsistent. We set out to ascertain whether there might be an association between polymorphisms in exon 2 (codon 119, G→T) and exon 3 (codon 432, G→C) of CYP1B1 and breast cancer in a Chinese Han population in the rural region of Ningxia. Using an allele-specific polymerase chain reaction method and direct DNA sequencing, the presence or absence of the two CYP1B1 polymorphisms was investigated. Genotype and allele frequencies were analyzed in breast cancer cases (n = 152) and healthy age-matched controls (n = 156). The odds ratio (OR) of 119G→T or 432G→C in breast cancer cases and controls was 3.3 (95% CI: 1.28 to 8.28) and 2.8 (95% CI: 1.04 to 7.51), respectively. In addition, the OR for people with both polymorphisms (119T and 432C) was 4.69 (95% CI: 1.97 to 11.19). Our results suggest that certain polymorphisms in the CYP1B1 gene might increase risk for breast cancer among Han Chinese, perhaps because they influence the efficiency of CYP1B1 bio-transformation of oestrogens or pro-carcinogens into DNA-reactive electrophiles that may act as cancer-initiating agents. PMID:20212917

  14. Operational Colour Vision in the Modern Aviation Environment (la Vision des couleurs dans l’environnement aeronautique operationnel d’ aujourd hui)

    Science.gov (United States)

    2001-03-01

    recommended. The Nagel II is no longer in production . Advantages: test has a long and hallowed history that is well respected. Disadvantages: expensive...Illuminator (Catalog No. 1388R) from Richmond Products , 1021 Rogers Circle, Suite 6, Boca Raton FL, 33487-2894. Phones:1-800-448-4538 and 407-994-2112...III Antineoplastics Mercaptopurine II Vincristine II Antirheumatics Ibuprofen II Colours appear faded Indomethacin III Antispasmodics

  15. La loi francaise de 2004 sur les signes religieux ostentatoires dans l'école publique: Ses conséquences et son fonctionnement aujourd'hui

    OpenAIRE

    Fjermestad, Berit

    2011-01-01

    This thesis treats the consequences of the French law that was passed in 2004, stating that all religious and ostentatious signs in public schools are illegal. In order to make the consequences of this law clear, I have been interviewing teachers, headmasters and students in schools in Paris and its surrounding suburban areas. This is not a quantitative study, but rather a qualitative research. Because there are a limited number of interviewees, it is important to e...

  16. The Construction of Islamic Social-Cultural Space in a Mixed Community of Hui and Han---the Case of Nagu,Yunnan Province

    Institute of Scientific and Technical Information of China (English)

    Xue Ximing; Yang Xihao; Ma Chuang

    2015-01-01

    The cultural space of multi ethnic residential regions is always diverse and complicat-ed,and the conflicts and integration of multi cul-tures is the main driving force in the process of constructing cultural space. The structure of this kind of culture space is not always stable or un-changeable. On one hand,the nature of cultural space is that it will exhibit new changes following with a deepening of the degree of integration among various cultures,which in turn might play an ac-tive role on the self-renewal of the cultural space. On the other hand,the dramatic cultural conflict produced from cultural misunderstandings might split the former cultural space,especially if some of the ethnic religions or belief systems are misun-derstood. In this case,ethnic or religious conflicts will be unavoidable—and,this will further influ-ence the social stability of a multi-ethnic country or region. Hence,the research on the form and the mechanism for constructing the cultural space of a multi-ethnic residential community becomes very important.

  17. Améliorer votre efficacité techniques d'aujourd'hui pour en faire plus en moins de temps

    CERN Document Server

    Savoyat, Bruno

    2012-01-01

    Quels que soient votre fonction, votre métier ou votre mission dans l'entreprise, ce livre pragmatique peut vous ouvrir les chemins d'une nouvelle vie. Il a été conçu et écrit pour vous rendre service et pour vous aider à gagner en efficacité. Les meilleures pratiques y ont été retenues pour vous. Certaines sont utilisées avec succès par plus d'un million de personnes à travers le monde. Leur mise en oeuvre est simple pour un impact maximal sur votre productivité, sur la qualité de votre travail et sur la satisfaction que vous retirerez de votre quotidien professionnel. Les principes et les conseils d'efficacité décrits dans ce livre peuvent être appliqués seul comme en équipe, et être généralisés à l'ensemble d'une entreprise. Vous pouvez choisir de les découvrir par une lecture du début à la fin, qui vous permettra une révision systématique de votre manière de travailler et de votre potentiel de gains en efficacité. Mais vous pouvez également opter pour une découverte théma...

  18. Photovoltaics in Algeria, today's experiences and perspectives of tomorrow; Le photovoltaique en Algerie, experiences d'aujourd'hui et perspectives de demain

    Energy Technology Data Exchange (ETDEWEB)

    Sahouane, Mehdi

    2010-09-15

    The communication describes Algeria's experience in the use of photovoltaics, principal renewable energy type used in the country, through the electrification of around 900 homes in 18 villages. This realization represents one of the largest projects accomplished by public powers in this domain with an installed power of 453KWc, which corresponds to 20% of the solar power currently exploited. Actions for the development of renewable energy in terms of realizations and regulations are listed, explaining the energy policy of Algeria which has fixed its contribution to the national energy balance at a level of 5% for 2017. [French] La communication decrit l'experience de l'Algerie dans l'utilisation du photovoltaique, principal type d'energie renouvelable utilisee dans le pays, a travers l'electrification d'environs 900 foyers repartis sur 18 villages. Cette realisation represente l'un des plus grands projets accomplis par les pouvoirs publics dans ce domaine avec une puissance installee de 453 KWc ce qui correspond a 20% de la puissance solaire presentement exploitee. Les actions destinees au developpement des energies renouvelables en matiere de realisations et reglementation sont citees explicitant la politique energetique de l'Algerie qui se fixe un taux de contribution au bilan energetique national de 5% pour 2017.

  19. The current status of coal liquefaction technologies - Panorama 2008; La liquefaction du charbon: ou en est-on aujourd'hui? - Panorama 2008

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    In 2008, a first coal liquefaction unit to produce motor fuel (20,000 BPSD) will come on-stream in Shenhua, China (in the Ercos region of Inner Mongolia). Other, more ambitious projects have been announced in China for between now and 2020. Since oil production is expected to peak in the medium term, this technology may develop regionally in the next 20 years to cover ever-increasing demand for motor fuel.

  20. Verlies van (t)huis en haard. Het belang van verliesbegeleiding als onderdeel van de maatschappelijke begeleiding binnen het Vluchtelingenwerk, regio Utrecht

    NARCIS (Netherlands)

    Hoogenberk, Birgit

    2014-01-01

    Loss of home and house. The importance of loss counseling as a part of refugee social supportIn this article it is advocated that it is important that the implementation of loss counseling is part of social support for refugees, also called integrative eclectic working. Social support from

  1. Health-state utilities in a prisoner population: a cross-sectional survey

    Directory of Open Access Journals (Sweden)

    Levy Michael H

    2009-08-01

    Full Text Available Abstract Background Health-state utilities for prisoners have not been described. Methods We used data from a 1996 cross-sectional survey of Australian prisoners (n = 734. Respondent-level SF-36 data was transformed into utility scores by both the SF-6D and Nichol's method. Socio-demographic and clinical predictors of SF-6D utility were assessed in univariate analyses and a multivariate general linear model. Results The overall mean SF-6D utility was 0.725 (SD 0.119. When subdivided by various medical conditions, prisoner SF-6D utilities ranged from 0.620 for angina to 0.764 for those with none/mild depressive symptoms. Utilities derived by the Nichol's method were higher than SF-6D scores, often by more than 0.1. In multivariate analysis, significant independent predictors of worse utility included female gender, increasing age, increasing number of comorbidities and more severe depressive symptoms. Conclusion The utilities presented may prove useful for future economic and decision models evaluating prison-based health programs.

  2. A systematic literature review of health state utility values in head and neck cancer.

    Science.gov (United States)

    Meregaglia, Michela; Cairns, John

    2017-09-02

    Health state utility values (HSUVs) are essential parameters in model-based economic evaluations. This study systematically identifies HSUVs in head and neck cancer and provides guidance for selecting them from a growing body of health-related quality of life studies. We systematically reviewed the published literature by searching PubMed, EMBASE and The Cochrane Library using a pre-defined combination of keywords. The Tufts Cost-Effectiveness Analysis Registry and the School of Health and Related Research Health Utilities Database (ScHARRHUD) specifically containing health utilities were also queried, in addition to the Health Economics Research Centre database of mapping studies. Studies were considered for inclusion if reporting original HSUVs assessed using established techniques. The characteristics of each study including country, design, sample size, cancer subsite addressed and demographics of responders were summarized narratively using a data extraction form. Quality scoring and critical appraisal of the included studies were performed based on published recommendations. Of a total 1048 records identified by the search, 28 studies qualified for data extraction and 346 unique HSUVs were retrieved from them. HSUVs were estimated using direct methods (e.g. standard gamble; n = 10 studies), multi-attribute utility instruments (MAUIs; n = 13) and mapping techniques (n = 3); two studies adopted both direct and indirect approaches. Within the MAUIs, the EuroQol 5-dimension questionnaire (EQ-5D) was the most frequently used (n = 11), followed by the Health Utility Index Mark 3 (HUI3; n = 2), the 15D (n = 2) and the Short Form-Six Dimension (SF-6D; n = 1). Different methods and types of responders (i.e. patients, healthy subjects, clinical experts) influenced the magnitude of HSUVs for comparable health states. Only one mapping study developed an original algorithm using head and neck cancer data. The identified studies were considered

  3. Cost-effectiveness analyses of elective orthopaedic surgical procedures in patients with inflammatory arthropathies

    DEFF Research Database (Denmark)

    Osnes-Ringen, H.; Kvamme, M. K.; Sønbø Kristiansen, Ivar

    2011-01-01

    . The health benefit from surgery was subsequently translated into QALYs. The direct treatment costs in the first year were, for each patient, derived from the hospital's cost per patient accounting system (KOSPA). The costs per QALY were estimated and future costs and benefits were discounted at 4%. Results......Objective: To examine the costs per quality-adjusted life year (QALY) gained for surgical interventions in patients with inflammatory arthropathies, and to compare the costs per QALY gained for replacement versus non-replacement surgical interventions. Methods: In total, 248 patients [mean age 57......: Improvement in utility at 1-year follow-up was 0.10 with EQ-5D and 0.03 with SF-6D (p cost per QALY gained was EUR 5000 for hip replacement surgery (EUR18 600 using SF-6D) and EUR 10 500 (EUR 48 500 using SF-6D) for all replacement procedures. The 5-year cost per QALY was EUR 17...

  4. Quality of life in asthma patients

    OpenAIRE

    Lara Noronha Ferreira; Ulisses Brito; Pedro Lopes Ferreira

    2010-01-01

    In this paper we present a study whose main aim is the measurement of the Health Related Quality of Life (HRQoL) of patients with asthma and the presentation of a first draft of normative values as measured by the SF-6D for asthma patients. In addition, we investigate how far non-disease-specific HRQoL measures can distinguish groups in terms of sociodemographic characteristics.The Portuguese versions of the EQ-5D, SF-6D, AQLQ(S) and ACQ were administered using personal interviews to a repres...

  5. The SMPR from yesterday and today for the energy production; Les RPMP d'hier et d'aujourd'hui pour la production d'energie

    Energy Technology Data Exchange (ETDEWEB)

    Barre, B. [Cogema, Dir. R and D, 78 - Velizy Villacoublay (France)

    2002-07-01

    The historical aspects of the Small and Medium Power Reactors (SMPR) are presented. The little reactors often be used in domains where the economical aspects were not important. The fight between medium and big profits historically to the biggest reactors. (author)

  6. A particular light on todays and tomorrows urban energies: perceptions and views of the young generation; Un eclairage particulier sur les energies urbaines d`aujourd`hui et de demain: perceptions et regards des jeunes

    Energy Technology Data Exchange (ETDEWEB)

    Martin, V.; Strauss, N.; Jaladis, S.; Waroux, D.

    1995-12-31

    In the framework of prospective studies on the town of the future, an inquiry with questionnaire was carried out on a pool of 230 students from 5 schools of the western suburb of Paris (France) in order to have an idea about their representations of todays energies, about their consumption habits, their living attitudes and their transportation practices, and about their apprehension of these domains in the 15-20 forthcoming years. For the present day, they spontaneously make reference to the solar and nuclear energies but they do not make distinction between energy source and final energy. Environment is a major concern threw the pollution aspects and is positioned just behind the society themes (unemployment, AIDS, exclusion). They favour the electric power for the domestic uses. They have a rather pessimistic vision of the future of energy resources. According to their opinion, electric power, bio-fuels and solar energy will be the future energy sources for transportation systems, electricity will dominate the domestic uses and they will be reticent with respect to the domestic development of safety networks for goods and people. The cross-comparison between sexes and occupational branches reveals three groups: modernist, conservative and ecologist. (J.S.)

  7. A particular light on todays and tomorrows urban energies: perceptions and views of the young generation; Un eclairage particulier sur les energies urbaines d`aujourd`hui et de demain: perceptions et regards des jeunes

    Energy Technology Data Exchange (ETDEWEB)

    Martin, V; Strauss, N; Jaladis, S; Waroux, D

    1996-12-31

    In the framework of prospective studies on the town of the future, an inquiry with questionnaire was carried out on a pool of 230 students from 5 schools of the western suburb of Paris (France) in order to have an idea about their representations of todays energies, about their consumption habits, their living attitudes and their transportation practices, and about their apprehension of these domains in the 15-20 forthcoming years. For the present day, they spontaneously make reference to the solar and nuclear energies but they do not make distinction between energy source and final energy. Environment is a major concern threw the pollution aspects and is positioned just behind the society themes (unemployment, AIDS, exclusion). They favour the electric power for the domestic uses. They have a rather pessimistic vision of the future of energy resources. According to their opinion, electric power, bio-fuels and solar energy will be the future energy sources for transportation systems, electricity will dominate the domestic uses and they will be reticent with respect to the domestic development of safety networks for goods and people. The cross-comparison between sexes and occupational branches reveals three groups: modernist, conservative and ecologist. (J.S.)

  8. Un savoir thérapeutique hybride et mobile : éclairage sur la recherche médicale en médecine chinoise en Chine aujourd'hui

    OpenAIRE

    Micollier , Evelyne

    2011-01-01

    The issue of innovations in TCM (zhongyi) - the Chinese medicine integrated in the public health system promoted by the post-1949 Chinese government, is approached through the case-study of the ongoing biomedicalisation of TCM research and the use of 'evidence-based medicine' (EBM) through clinical trials. Three points will be discussed: the fi rst introduces a 'plural' medical context and a recent debate in China on the issue of pulling-out TCM from the public health-care system involving of...

  9. The impact of diabetes mellitus and other chronic medical conditions on health-related Quality of Life: Is the whole greater than the sum of its parts?

    Directory of Open Access Journals (Sweden)

    Fong Kok-Yong

    2005-01-01

    Full Text Available Abstract Background Diabetes mellitus (DM is an important public health concern, the impact of which is increased by the high prevalence of co-existing chronic medical conditions among subjects with DM. The aims of this study were therefore to (1 evaluate the impact of DM and co-existing chronic medical conditions on health-related quality of life (HRQoL (which could be additive, synergistic or subtractive; (2 to determine the extent to which the SF-6D (a single-index preference measure captures the multidimensional information provided by the SF-36 (a profile measure. Methods Using data from a cross-sectional, population-based survey of Chinese, Malay and Indians in Singapore, we developed 9 separate multiple linear regression models, with each SF-36 scale or SF-6D index score being the dependent variable for one model. The influence of DM and a second chronic medical condition (hypertension (HTN, heart disease (HD, musculoskeletal illnesses (MS and their interactions were studied after adjusting for the influence of potential confounding variables. Results Among 5,224 subjects, the prevalence of DM, HTN, HD and MS were 5.9%, 10.7%, 2.4% and 26.6% respectively. DM lowered SF-36 scores by more than 2 points on 3 SF-36 scales and lowered SF-6D scores by 0.03 points. Subjects with DM and HTN, DM and HD or DM and MS experienced further lowering of SF-36 scores exceeding 2 points on at least 6 scales and further lowering of SF-6D scores by 0.05, 0.08 and 0.10 points respectively. Generally, DM and co-existing medical conditions exerted additive effects on HRQoL, with the exception of DM and heart disease, where a subtractive effect was noted. SF-6D index scores generally reflected the patterns of influence of DM and chronic medical conditions on SF-36 scores. Conclusion DM and chronic medical conditions generally reduced HRQoL in this multiethnic general population in an additive, rather than synergistic or subtractive fashion. In this study, the SF

  10. Qualidade de vida em doentes com asma Quality of life in asthma patients

    OpenAIRE

    Lara Noronha Ferreira; Ulisses Brito; Pedro Lopes Ferreira

    2010-01-01

    Neste artigo é descrito um estudo, cujo objectivo é a medição da qualidade de vida relacionada com a saúde (QdVRS) de doentes com asma e a apresentação de uma primeira aproximação aos valores normativos, com base no SF-6D, para aquele tipo de doentes. Pretende-se ainda averiguar a capacidade de medidas genéricas de medição da QdVRS distinguirem grupos em termos de características sociodemográficas. Aplicaram-se, por entrevista pessoal, as versões portuguesas do EQ-5D, do SF-6D, do AQLQ(S) e d...

  11. Do modern total knee replacements offer better value for money? A health economic analysis.

    Science.gov (United States)

    Hamilton, David F; Clement, Nicholas D; Burnett, Richard; Patton, James T; Moran, Mathew; Howie, Colin R; Simpson, A H R W; Gaston, Paul

    2013-11-01

    Cost effectiveness is an increasingly important factor in today's healthcare environment, and selection of arthroplasty implant is not exempt from such concerns. Quality adjusted life years (QALYs) are the typical tool for this type of evaluation. Using this methodology, joint arthroplasty has been shown to be cost effective; however, studies directly comparing differing prostheses are lacking. Data was gathered in a single-centre prospective double-blind randomised controlled trial comparing the outcome of modern and traditional knee implants, using the Short Form 6 dimensional (SF-6D) score and quality adjusted life year (QALY) methodology. There was significant improvement in the SF-6D score for both groups at one year (p traditional design at one year (0.141 versus 0.143, p = 0.94). This difference resulted in the modern implant costing £298 less per QALY at one year. This study demonstrates that modern implant technology does not influence the cost-effectiveness of TKA using the SF-6D and QALY methodology. This type of analysis however assesses health status, and is not sensitive to joint specific function. Evolutionary design changes in implant technology are thus unlikely to influence QALY analysis following joint replacement, which has important implications for implant procurement.

  12. Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting.

    Directory of Open Access Journals (Sweden)

    Samantha L Eaton

    Full Text Available Western blotting has been a key technique for determining the relative expression of proteins within complex biological samples since the first publications in 1979. Recent developments in sensitive fluorescent labels, with truly quantifiable linear ranges and greater limits of detection, have allowed biologists to probe tissue specific pathways and processes with higher resolution than ever before. However, the application of quantitative Western blotting (QWB to a range of healthy tissues and those from degenerative models has highlighted a problem with significant consequences for quantitative protein analysis: how can researchers conduct comparative expression analyses when many of the commonly used reference proteins (e.g. loading controls are differentially expressed? Here we demonstrate that common controls, including actin and tubulin, are differentially expressed in tissues from a wide range of animal models of neurodegeneration. We highlight the prevalence of such alterations through examination of published "-omics" data, and demonstrate similar responses in sensitive QWB experiments. For example, QWB analysis of spinal cord from a murine model of Spinal Muscular Atrophy using an Odyssey scanner revealed that beta-actin expression was decreased by 19.3±2% compared to healthy littermate controls. Thus, normalising QWB data to β-actin in these circumstances could result in 'skewing' of all data by ∼20%. We further demonstrate that differential expression of commonly used loading controls was not restricted to the nervous system, but was also detectable across multiple tissues, including bone, fat and internal organs. Moreover, expression of these "control" proteins was not consistent between different portions of the same tissue, highlighting the importance of careful and consistent tissue sampling for QWB experiments. Finally, having illustrated the problem of selecting appropriate single protein loading controls, we demonstrate

  13. Assessing the empirical validity of alternative multi-attribute utility measures in the maternity context

    Directory of Open Access Journals (Sweden)

    Morrell Jane

    2009-05-01

    Full Text Available Abstract Background Multi-attribute utility measures are preference-based health-related quality of life measures that have been developed to inform economic evaluations of health care interventions. The objective of this study was to compare the empirical validity of two multi-attribute utility measures (EQ-5D and SF-6D based on hypothetical preferences in a large maternity population in England. Methods Women who participated in a randomised controlled trial of additional postnatal support provided by trained community support workers represented the study population for this investigation. The women were asked to complete the EQ-5D descriptive system (which defines health-related quality of life in terms of five dimensions: mobility, self care, usual activities, pain/discomfort and anxiety/depression and the SF-36 (which defines health-related quality of life, using 36 items, across eight dimensions: physical functioning, role limitations (physical, social functioning, bodily pain, general health, mental health, vitality and role limitations (emotional at six months postpartum. Their responses were converted into utility scores using the York A1 tariff set and the SF-6D utility algorithm, respectively. One-way analysis of variance was used to test the hypothetically-constructed preference rule that each set of utility scores differs significantly by self-reported health status (categorised as excellent, very good, good, fair or poor. The degree to which EQ-5D and SF-6D utility scores reflected alternative dichotomous configurations of self-reported health status and the Edinburgh Postnatal Depression Scale score was tested using the relative efficiency statistic and receiver operating characteristic (ROC curves. Results The mean utility score for the EQ-5D was 0.861 (95% CI: 0.844, 0.877, whilst the mean utility score for the SF-6D was 0.809 (95% CI: 0.796, 0.822, representing a mean difference in utility score of 0.052 (95% CI: 0.040, 0

  14. Web Usability Policies/Standards/Guidelines Do Not Influence Practices at ARL Academic Libraries. A Review of: Chen, Yu‐Hui, Carol Anne Germain and Huahai Yang. “An Exploration into the Practices of Library Web Usability in ARL Academic Libraries.” Journal of the American Society for Information Science and Technology 60.5 (2009: 953‐68.

    Directory of Open Access Journals (Sweden)

    Shandra Protzko

    2009-12-01

    Full Text Available Objective – To survey the current status of Web usability Policies/Standards/Guidelines (PSGs found in academic libraries of the Association of Research Libraries (ARL. Researchers sought to investigate whether PSGs are in place, the levels of difficulty surrounding implementation, the impact of PSGs on design, testing, and resource allocation, and the relationship between ARL ranking and usability practice or PSGs.Design – Survey.Setting – North America.Subjects – Academic libraries of the ARL.Methods – An 18‐question survey consisting of multiple choice, Likert scale, and open‐ended questions was sent to all 113 ARL libraries in November 2007. Survey recipients were selected as the person in charge of Web site usability by visiting library Web sites and phone inquiry. The survey was concluded in January 2008 with a response rate of 74% (84 institutions. The researchers used t‐test to detect any difference in ARL library ranking between libraries with and without PSGs. Pair‐wise t‐tests were conducted to identify gaps in difficulty implementing PSGs. In addition, they used Pearson’s Correlation to investigate any significant correlations between variables such as ARL rank and resource allocation.Main Results – Of the 84 respondents, 34 (40% have general library Web PSGs and 25 (30% have specific usability PSGs; 41 (49% have at least one type of in‐library PSG. Of the 43 (51% libraries that do not have PSGs, 30 (36% are at universities with institutional Web usability PSGs; 26 (87% follow those guidelines. There was no statistically significant relationship between ARL ranking and PSG status (see Table 1. The authors asked about difficulty in implementing PSGs. Of the 32 libraries responding to a question about general library Web PSGs, most had slight or moderate difficulty. Twenty‐three libraries with specific usability PSGs identified difficulty levels; some had no difficulty, but a majority had moderate difficulty. For the 26 libraries using institutional Web usability PSGs, most had no or slight difficulty. Pair‐wise t‐tests showed that library Web usability PSGs were significantly more difficult to implement than university Web usability PSGs. Enforcement/agreement issues were reported as the primary difficulty in implementing in‐library PSGs. Technical issues and ambiguity were obstacles at the institutional level. More than half of the 84 libraries have Web advisory committees and about one third have usability committees or Web usability subcommittees. Several libraries answered that they have none of these committees, but indicated that they have some sort of ad hoc committee or user study group to address usability issues. Of the 84 respondents, 71 (85% have conducted usability testing. Sixty‐two libraries (73.8% rated usability testing as important, very important, or extremely important: the rate given for the importance of usability testing did not correlate with ARL ranking. Cited most often in open ended questioningwere the importance of iterative testing, library wide buy‐in, and staff and resource availability. Main web pages were tested most frequently. Fifty‐three libraries (74.6% tested their lower level pages at least once. OPACs were tested the least often. The amount of testing was impacted neither by the existence of library Web PSGs nor usability PSGs. The top two testing methods were in‐person observation and think aloud protocol.Of the 84 libraries, 24 (28% reported having staff dedicated to Web usability issues; twenty full‐time staff and four part‐time staff. There was a weak association between ARL ranking and hours worked by dedicated staff; no association existed for regular staff who take on Web responsibilities. Fifty‐one (60% of libraries had regular staff whose duties included Web usability; forty‐six full‐time and five part‐time. Training did not correlate to amount of testing methods used. There was a weak link between ALR ranking and availability of resources and, the authors showed, more testing was done as resources increased. In response to a query about future Web usability plans, the focus was on usability testing and site redesign, with only three libraries planning to refine or establish usability PSGs.Conclusion – The authors hypothesized that “web usability PSGs would influence usability practice within libraries and other institutions” (953. The data show that PSGs do not influence practices. The authors conclude that there is no significant relationship between PSGs and testing practices or PSGs and the availability of resources. Likewise, ARL ranking had no effect on the establishment of usability PSGs. Most libraries are conducting usability testing, and there was a weak link between ARL ranking and availability of testing resources. Highlighted in the open‐ended questions is the lack of usability expertise among stakeholders. Workload, inadequate human resources, and lack of organizational cohesion are also cited as barriers to the adoption of Web usability PSGs. The authors speculate that Web professionals likely use their own working knowledge and internalized guidelines without having formal documentation. The authors further speculate that the difficulty related to creating mental models that adequately represent library tasks may hinder the use of formal usability PSGs. Additionally, libraries may not regard the lack of usability PSGs as a liability, especially in light of the lack of government mandates or standards. The authors recommend educational efforts for key players on the value of Web usability, support for hiring dedicated staff, and formal documentation to guide design practice. The authors plan to compare the collected PSGs in an upcoming project. Future research could focus on non‐ARL libraries, the relationship between PSGs and user experience, and Content Management System (CMS usability characteristics.

  15. Comparison of health-related quality of life and functional recovery measurement tools in out-of-hospital cardiac arrest survivors.

    Science.gov (United States)

    Andrew, Emily; Nehme, Ziad; Bernard, Stephen; Smith, Karen

    2016-10-01

    Although a number of validated health-related quality of life (HR-QOL) instruments exist for critical care populations, a standardised approach to assessing the HR-QOL of out-of-hospital cardiac arrest (OHCA) survivors has not been developed. We sought to compare the responses of 12-month OHCA survivors to three HR-QOL and functional recovery instruments, and assess instrument validity. The Victorian Ambulance Cardiac Arrest Registry invited 12-month OHCA survivors to participate in telephone follow-up between January 2011 and December 2015. Responders provided answers to the 12 Item Short Form Health Survey (SF-12), Three-Level EuroQol-5D (EQ-5D-3L) and the Glasgow Outcome Scale-Extended (GOSE). The SF-12 was also used to derive the SF-6D. Responses were used to assess the interpretability and construct validity of the instruments. A total of 1188 patients and proxies responded. Large ceiling effects were observed for the EQ-5D-3L (patients=46%, proxies=23%). Substantial variability was also observed in SF-6D responses for patients who reported full health according to the EQ-5D-3L. For patient responders, the strongest correlations were observed between the EQ-5D-3L index score and SF-6D (ρ=0.65, pGOSE outcome and lower or upper good recovery (pGOSE suggest that these may be useful measures of HR-QOL and functional recovery in OHCA survivors. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  16. Impact of recombinant TSH on quality of life in thyroid carcinoma patients undergoing remnant ablation or diagnostic whole body scanning

    International Nuclear Information System (INIS)

    Schroeder, Pamela R.; Ladenson, Paul W.; for the Members of the Thyrogen Trials

    2005-01-01

    Full text: Thyroid remnant ablation with 131 I is often necessary in the initial treatment of thyroid carcinoma. A recent study demonstrated that use of recombinant TSH (rh TSH) was equivalently effective to withdrawal from levothyroxine (L-T 4 ) for postoperative remnant ablation. Quality of life was also shown to be negatively impacted in patients withdrawn from L-T 4 , but not those maintained euthyroid and treated after rh TSH. In this study, we compare the impact of rh TSH on quality of life in patients undergoing remnant ablation versus those undergoing diagnostic whole body scanning (WBS) in a previous trial. Health-related quality of life was measured using the SF-36 survey, which consists of 8 domains describing the physical and mental functioning of patients and 2 physical and mental summary domains, in both trials at baseline on L-T 4 , after rh TSH while on L-T 4 and after L-T 4 withdrawal. Mean SF-36 scores declined from the rh TSH treatment versus L-T 4 withdrawal in both trials to a similar extent in all 8 domains and the 2 summary domains, as evidenced by overlapping 95% confidence intervals. Further SF-6D scores, which summarize all 8 domains in a single zero-to-one metric, were used to characterize the overall quality of life among patients in the two trials. The SF-6D scores for patients after rh TSH administration in the diagnostic and ablation trials were 0.803 and 0.714, respectively. In contrast, SF-6D scores for patients undergoing L-T 4 withdrawal in the diagnostic and ablation trials were 0.637 and 0.548, respectively (p 4 withdrawal both experience a comparable decrease in quality of life, which can be prevented by use of rh TSH in the euthyroid state. (author)

  17. The impact of a revised EQ-5D population scoring on preference-based utility scores in an inflammatory arthritis cohort.

    LENUS (Irish Health Repository)

    Adams, Roisin

    2012-02-01

    BACKGROUND AND OBJECTIVE: It is well established that there are problems with the EQ-5D. This is due to the original scoring methods used and how negative time trade-off (TTO) values were treated. A revised scoring method has been published. This article applies this to an inflammatory arthritis cohort. The objective is to examine the impact of a revised scoring system for the EQ-5D (UK) TTO on the utility estimates and in the case of rheumatoid arthritis, to explore the impact of using different utility metrics on the incremental cost-effectiveness ratio (ICER) results of an economic model. METHODS: A total of 504 patients with inflammatory arthritis were rescored using revised EQ-5D scoring, which uses an episodic random utility model to deal with negative TTO values. Differences in utility scores were compared and the new mapping coefficients were obtained. These were then used in an economic model to examine the impact on the ICER. RESULTS: In rheumatoid arthritis, the overall change is less for the revised EQ-5D scoring than with the original EQ-5D (TTO) but greater than the SF-6D: EQ-5D UK -0.22 (95% confidence interval [CI] -0.30 to -0.15), revised EQ-5D UK -0.16 (95% CI -0.21 to -0.10) and SF-6D -0.08 (95% CI -0.11 to -0.05). A similar trend is seen in the psoriatic arthritis group. The economic model produced different ICERs, when different utility measures were used; EQ-5D (TTO) euro42,402, SF-6D euro111,788, and revised EQ-5D (TTO) euro57,747. CONCLUSION: In the context of inflammatory arthritis, this article demonstrates that a revised scoring for EQ-5D may have a significant impact on utility estimates and on the output of the economic model.

  18. Health-related quality of life of Southern Chinese with chronic hepatitis B infection

    Directory of Open Access Journals (Sweden)

    Lam Elegance TP

    2009-06-01

    Full Text Available Abstract Background Few studies have evaluated the health-related quality of life (HRQOL of Southern Chinese with chronic hepatitis B (CHB infection. Aim To evaluate the HRQOL of Chinese patients at different stages of CHB infection and to find out factors associated with HRQOL. Methods 520 Chinese adult CHB patients of whom 156 were uncomplicated, 102 had impaired liver function, 139 had cirrhosis and 123 had hepatocellular carcinoma (HCC were interviewed with a structured questionnaire, the SF-36 Health Survey version 2 (SF-36v2, and the Chronic Liver Disease Questionnaire (CLDQ. The differences in SF-6D health preference values and SF-36v2 scores between each CHB group and Hong Kong population norms were assessed by t-test. ANOVA was used to compare the mean SF-6D health preference, SF-36v2 scores, and CLDQ scores among CHB groups. Multiple linear regressions were performed to identify determinants of HRQOL. Results CHB patients had significantly lower SF-36v2 scores than the population norm. The SF-6D values of CHB patients with uncomplicated disease, impaired liver function, HCC and cirrhosis were 0.755, 0.745, 0.720 and 0.701, respectively, all significantly lower than the population norm of 0.787. Advanced stage of CHB illness, anti-viral treatment, bilirubin level, psychological co-morbidity, younger age and female were associated with poorer HRQOL. Conclusion CHB infection had a negative impact on HRQOL. There was a progressive decrease in health preference values with CHB disease progression. The results can be used for the estimation of quality adjusted life years (QALYs for CHB patients in cost effectiveness or cost utility studies. Trial Registration http://www.hkclinicaltrials.com; HKCTR-151.

  19. Child health-related quality of life following neurocritical care for traumatic brain injury: an analysis of preference-weighted outcomes.

    Science.gov (United States)

    Tilford, John M; Aitken, Mary E; Goodman, Allen C; Fiser, Debra H; Killingsworth, Jeffrey B; Green, Jerril W; Adelson, P David

    2007-01-01

    Cost-effectiveness analysis relies on preference-weighted health outcome measures as they form the basis for quality adjusted life years. Studies of preference-weighted outcomes for children following traumatic brain injury are lacking. This study seeks to describe the preference-weighted health outcomes of children following a traumatic brain injury at 3- and 6-months following pediatric intensive care unit (ICU) discharge. Children aged 5-17 who required ICU admission and endotracheal intubation or mechanical ventilation. The Quality of Well-being (QWB) score was used to describe preference-weighted outcomes. Clinical measures from the intensive care unit stay were used to estimate risk of mortality. Risk of mortality, Glasgow coma scores, patient length of stay in the intensive care unit, and parent-reported items from the Child Health Questionnaire (CHQ) were used to test construct validity. Subject data were obtained from nine pediatric intensive care units with consent procedures approved by representative institutional review boards. Medical records containing clinical information from the ICU stay were abstracted by the study coordinating center. Caregivers of children were contacted by telephone for follow-up interviews at 3- and 6-months following ICU discharge. All interviews were conducted by telephone with the primary caregiver of the injured child. Preference score statistics are presented overall and in relation to characteristics of the patient and their ICU admission. A response rate of 59% was achieved for the 3-month interviews (N = 56) and 67% for the 6-month interviews (N = 65) for caregivers of children aged 5 years and above that consented to participate. Overall, QWB scores averaged 0.508 (95% CI: 0.454-0.562) at the 3-month interview and 0.582 (95% CI: 0.526-0.639) at the 6-month interview. For both interview periods, scores ranged from 0.093 to 1.0 on a 0-1 value scale, where 0 represents death and 1 represents perfect health. Specific

  20. Quality of life in asthma patients

    Directory of Open Access Journals (Sweden)

    Lara Noronha Ferreira

    2010-01-01

    Full Text Available In this paper we present a study whose main aim is the measurement of the Health Related Quality of Life (HRQoL of patients with asthma and the presentation of a first draft of normative values as measured by the SF-6D for asthma patients. In addition, we investigate how far non-disease-specific HRQoL measures can distinguish groups in terms of sociodemographic characteristics.The Portuguese versions of the EQ-5D, SF-6D, AQLQ(S and ACQ were administered using personal interviews to a representative sample of the Portuguese population with asthma.Most of the individuals did not report significant problems in the dimensions used, with the exception of the physical functioning, where individuals reported moderate limitations. The mean utility value was 0.86. Male gender, young, single, individuals with high educational attainment level, employed, individuals with high income and those residing in urban areas reported higher utility levels. As expected, those who were in a severe stadium of the disease reported lower mean utility levels than those who were in a less severe stadium of the disease. Normative values for the SF-6D were computed for patients with asthma by gender, age, marital status, educational attainment level, employment status, area of residence and average monthly net income.The preference-based measures used in this study distinguish patient groups with asthma in terms of socio-demographic groups. The normative values can be used in economic evaluation and clinical studies as they incorporate patients’ preferences and translate the value attributed to patients’ health state. Resumo: Neste artigo é descrito um estudo, cujo objectivo é a medição da qualidade de vida relacionada com a saúde (QdVRS de doentes com asma e a apresentação de uma primeira aproximação aos valores normativos, com base no SF-6D, para aquele tipo de doentes. Pretende-se ainda averiguar a capacidade de medidas gen

  1. Qualidade de vida em doentes com asma

    Directory of Open Access Journals (Sweden)

    Lara Noronha Ferreira

    2010-01-01

    Full Text Available Resumo: Neste artigo é descrito um estudo, cujo objectivo é a medição da qualidade de vida relacionada com a saúde (QdVRS de doentes com asma e a apresentação de uma primeira aproximação aos valores normativos, com base no SF-6D, para aquele tipo de doentes. Pretende-se ainda averiguar a capacidade de medidas genéricas de medição da QdVRS distinguirem grupos em termos de características sociodemográficas. Aplicaram-se, por entrevista pessoal, as versões portuguesas do EQ-5D, do SF-6D, do AQLQ(S e do ACQ a uma amostra representativa da população portuguesa com asma.A maioria dos indivíduos não apresentou problemas significativos nas dimensões medidas, excepto na função física, onde os indivíduos reportaram limitações moderadas. Em média, os inquiridos apresentam valores de utilidade de 0,86. Os homens, os mais jovens, os solteiros, os indivíduos com habilitações literárias mais elevadas, os empregados, os indivíduos com rendimentos mais elevados e aqueles que residiam em zonas urbanas foram os que reportaram níveis de utilidade mais elevados. Por outro lado, os indivíduos que se encontravam num estádio mais avançado da doença reportaram, como era de esperar, níveis médios de utilidade inferiores aos dos que se encontravam num estádio menos grave da doença. Foram obtidos valores normativos para o SF-6D para doentes com asma por género, grupo etário, estado civil, habilitações literárias, situação profissional, local de residência e rendimento médio mensal líquido.As medidas de utilidade baseadas em preferências utilizadas neste estudo discriminam adequadamente grupos de doentes com asma, de acordo com grupos sociodemográficos. Os valores normativos obtidos podem ser usados em estudos de avaliação económica e estudos clínicos, uma vez que incorporam as preferências dos doentes

  2. VALIDATION OF THE RUSSIAN VERSION OF A QUESTIONNAIRE FOR THE ASSESSMENT OF UTILITARIAN INDICES IN PEDIATRIC PRACTICE. STAGE II

    Directory of Open Access Journals (Sweden)

    I. V. Vinyarskaya

    2014-01-01

    Full Text Available Aim: To create the Russian-language version of the standardized international questionnaire Health Utilities Index (HUI applicable for children's age, on the basis of the relevant international requirements to linguistic ratification and validation of tools. Patients and methods: 427 children of the first and 233 children of the second health group have taken part in the research. Average age of patients made10.8 ± 4.6 years. Criteria validity of the HUI questionnaire was assessed by comparison of patients' answers who had the different health status, a convergent validity — by comparison of the HUI attributes with scales of the PedsQL questionnaire, reliability — by calculation of Cronbach's alfa and the analysis of correlations between questions of the HUI classification. Results: Between the first and second health group there were significant distinctions on each attribute of the HUI questionnaire (p < 0.001. Average value of a number of the reduced attributes significantly differed depending on the state of health of patients: the worse the state of health is, the higher number of limited attributes is (p < 0.05. Significant correlations between the scales estimating similar concepts on questionnaires HUI and PedsQL are established. In assessment of the reliability Cronbach's according to the HUI3 and HUI2 system made 0.79 and 0.8, respectively. Significantcorrelations between the questions estimating identical attributes (sight, hearing, speech, cognitive abilities are shown. The validity and reliability assessment executed for children with various state of health, allowed to assess all attributes of the HUI2 and HUI3 systems. The received results showed satisfactory psychometric properties of the new language version of a questionnaire. Conclusion: The offeredRussian version of the international questionnaire HUI is a validated tool for the development of utility coefficients for various chronic diseases in children, creation of the

  3. A review of preference-based measures for the assessment of quality of life in children and adolescents with cerebral palsy.

    Science.gov (United States)

    Mpundu-Kaambwa, Christine; Chen, Gang; Huynh, Elisabeth; Russo, Remo; Ratcliffe, Julie

    2018-03-22

    To examine the psychometric properties and suitability for use within the context of cerebral palsy research in children and adolescents of generic preference-based outcome measures (PROMs). Nine electronic databases were searched in this systematic review. The consensus-based standards for the selection of health measurement instruments (COSMIN) checklist were used to measure the psychometric properties of the PROMs. A meta-analysis was used to pool correlation coefficients for convergent validity using the Schmidt-Hunter method. Heterogeneity was assessed using the I-squared statistic (I 2 ). Four preference-based PROMs were identified from eight studies: Health Utilities Index-Mark 2 and 3 (HUI-2 and HUI-3, respectively), the Assessment Quality of Life-4 dimension (AQoL-4D) and the EuroQol-5 dimension 3 level (EQ-5D-3L). Only the HUI system was primarily developed for application with children/adolescents though health-state values for scoring the PROM were elicited from adults. The HUI-3 covered the most relevant constructs though it excludes important modules of health-related quality of life (HRQOL) such as activity limitations and participation restrictions. In terms of psychometric properties, evidence was presented for only five of COSMIN measurement properties: reliability (HUI3), measurement error (HUI-3), content validity (HUI-2 and HUI-3), Hypotheses testing (HUI-3 and AQoL-4D) and criterion validity (HUI-3). No papers reported on internal consistency, structural validity, cross-cultural validity or responsiveness of the preference-based measures in children and adolescents with cerebral palsy. This review highlights the dearth in studies using preference-based PROMs to measure HRQOL associated with cerebral palsy in children and adolescents. The HUI-3 demonstrated the strongest psychometric properties, though it does not cover all dimensions relevant to this population.

  4. Should We Stay or Should We Go Now? The Physical, Economic, Geopolitical, Social and Psychological Factors of Recovery from Catastrophic Disaster

    Science.gov (United States)

    2014-09-01

    Histoire d’aujourd’hui (Paris: Larousse, 2008). 54 Graham Evans and Jeffrey Newnham, The Penguin Dictionary of International Relations (London...Géopolitique: La Longue Histoire d’aujourd’hui. Paris: Larousse, 2008. Lammers, Cornelis Jacobus. Survey of Evacuation Problems and Disaster

  5. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Hua-Hsien Chiu1 Yi-Ting Tseng2 Hui-Pin Hsiao3 Hui-Hua Hsiao3. Department of Biotechnology, Fooyin University, Kaohsiung 831, Taiwan; School of Medical and Health Science, Fooyin University, Kaohsiung 831, Taiwan; Faculty of Medicine, College of Medicine, and Kaohsiung Medical University Hospital, Kaohsiung ...

  6. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. YU-HUI HOU. Articles written in Journal of Chemical Sciences. Volume 130 Issue 1 January 2018 pp 6. Efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents · DONG-JUN FU YU-HUI HOU SAI-YANG ZHANG ...

  7. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Hao-Hao Hui. Articles written in Journal of Chemical Sciences. Volume 120 Issue 3 May 2008 pp 347-351. Microwave-assisted efficient oxidation of internal alkynes to 1,2-diaryldiketones with DMSO/I2 · Min Chen Qin Zhao De-Bing She Ming-Yu Yang Hao-Hao Hui ...

  8. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. Hui Liang. Articles written in Sadhana. Volume 36 Issue 5 October 2011 pp 885-915. Current trends in multilingual speech processing · Hervé Bourlard John Dines Mathew Magimai-Doss Philip N Garner David Imseng Petr Motlicek Hui Liang Lakshmi Saheer Fabio Valente · More Details Abstract ...

  9. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. YAN HUI GENG. Articles written in Sadhana. Volume 43 Issue 3 March 2018 pp 34. Spectral element method for wave propagation on irregular domains · YAN HUI GENG GUO LIANG QIN JIA ZHONG ZHANG · More Details Abstract Fulltext PDF. A spectral element approximation of acoustic ...

  10. Sex and the City

    NARCIS (Netherlands)

    Scheen, L.M.

    2006-01-01

    Mian Mian pouring beer on Wei Hui’s head in a Shanghai bar; Wei Hui baring her breasts at a press conference; threats on the Internet – self-labelled Beauty Writers Mian Mian and Wei Hui fear no accusations in their public catfight over alleged plagiarism in turn-of-the-century Shanghai. The rivalry

  11. Tropical Journal of Pharmaceutical Research - Vol 17, No 5 (2018)

    African Journals Online (AJOL)

    Jun Lu, Hou-pan Song, Qin-hui Tuo, Qi-chang Zeng, Qin Wang, Ya-hui Huang, 809-815 ... Chemical composition and biological activities of n-butanol extract of ... Jude A. Udoye, Raymond I. Ozolua, Jude Nwokike, Jude Nwokike, 937-945 ...

  12. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Hui Shen. Articles written in Bulletin of Materials Science. Volume 30 Issue 2 April 2007 pp 101-104 Single Crystals. Piezoelectric properties of Sr3Ga2Ge4O14 single crystals · Anhua Wu Jiayue Xu Juan Zhou Hui Shen · More Details Abstract Fulltext PDF. A new piezoelectric ...

  13. The Health Utilities Index (HUI®: concepts, measurement properties and applications

    Directory of Open Access Journals (Sweden)

    Horsman John

    2003-10-01

    Full Text Available Abstract This is a review of the Health Utilities Index (HUI® multi-attribute health-status classification systems, and single- and multi-attribute utility scoring systems. HUI refers to both HUI Mark 2 (HUI2 and HUI Mark 3 (HUI3 instruments. The classification systems provide compact but comprehensive frameworks within which to describe health status. The multi-attribute utility functions provide all the information required to calculate single-summary scores of health-related quality of life (HRQL for each health state defined by the classification systems. The use of HUI in clinical studies for a wide variety of conditions in a large number of countries is illustrated. HUI provides comprehensive, reliable, responsive and valid measures of health status and HRQL for subjects in clinical studies. Utility scores of overall HRQL for patients are also used in cost-utility and cost-effectiveness analyses. Population norm data are available from numerous large general population surveys. The widespread use of HUI facilitates the interpretation of results and permits comparisons of disease and treatment outcomes, and comparisons of long-term sequelae at the local, national and international levels.

  14. Trauma in adolescents causes long-term marked deficits in quality of life: adolescent children do not recover preinjury quality of life or function up to two years postinjury compared to national norms.

    Science.gov (United States)

    Holbrook, Troy Lisa; Hoyt, David B; Coimbra, Raul; Potenza, Bruce; Sise, Michael J; Sack, Dan I; Anderson, John P

    2007-03-01

    Injury is a leading cause of death and preventable morbidity in adolescents. Little is known about long-term quality of life (QoL) outcomes in injured adolescents. The objectives of the present report are to describe long-term QoL outcomes and compare posttrauma QoL to national norms for QoL in uninjured adolescents from the National Health Interview Survey (NHIS). In all, 401 trauma patients aged 12 to 19 years were enrolled in the study. Enrollment criteria excluded spinal cord injury. QoL after trauma was measured using the Quality of Well-being (QWB) scale, a sensitive and well-validated functional index (range: 0 = death to 1.000 = optimum functioning). Patient outcomes were assessed at discharge, and 3, 6, 12, 18, and 24 months after discharge. NHIS data were based on 3 survey years and represent a population-based U.S. national random sample of uninjured adolescents. Major trauma in adolescents was associated with significant and marked deficits in QoL throughout the 24-month follow-up period, compared with NHIS norms for this age group. Compared with NHIS norms for QoL in uninjured adolescents aged 12 to 19 years (N = 81,216,835; QWB mean = 0.876), injured adolescents after major trauma had striking and significant QoL deficits beginning at 3-month follow-up (QWB mean = 0.694, p or=15 years) and female sex. Other significant risk factors for poor QoL outcomes were perceived threat to life, pedestrian struck mechanism, and Injury Severity Scores >16. Major trauma in adolescents is associated with significant and marked deficits in long-term QoL outcomes, compared with U.S. norms for healthy adolescents. Early identification and treatment of risk factors for poor long-term QoL outcomes must become an integral component of trauma care in mature trauma care systems.

  15. Sexual dysfunction after simultaneous pancreas-kidney transplantation

    DEFF Research Database (Denmark)

    Jürgensen, J S; Ulrich, C; Hörstrup, J H

    2008-01-01

    such as quality of life (QoL) have recently received increased attention among transplant recipients. However, the impact of erectile dysfunction on patient QoL has not been investigated in this high-risk group with a history of diabetes and uremia. We applied the International Index of Erectile Function (IIEF...... their sexual function to be worse than before, and 51% did not note any change. The QWB index was highest among the group of patients without erectile dysfunction, decreasing gradually but significantly with increasing severity. A direct impact of erectile dysfunction on QoL, as well as a confounding effect...

  16. Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.

    Directory of Open Access Journals (Sweden)

    Jing Wu

    Full Text Available OBJECTIVES: To compare health-related quality of life (HRQoL between patients with stable angina and the general population in China and to examine factors associated with HRQoL among patients with stable angina. METHODS: A cross-sectional HRQoL survey of stable angina patients recruited from 4 hospitals (n = 411 and the general population recruited from 3 Physical Examination Centers (n = 549 was conducted from July to December, 2011 in two large cities, Tianjin and Chengdu. HRQoL was assessed using the EQ-5D, EQ-VAS, and SF-6D instruments. The health status specific to patients with stable angina was assessed using the Seattle Angina Questionnaire (SAQ. Information on socio-demographic, clinical, and lifestyle factors were also collected. Nested regressions were performed to explore how these factors were associated with HRQoL in patients with stable angina. RESULTS: Compared with the general population (44.2 ± 10 years, 49.9% females, stable angina patients (68.1 ± 12 years, 50.4% females had significantly lower HRQoL scores in EQ-5D utility index (0.75 ± 0.19 vs. 0.90 ± 0.20, p<0.05, SF-6D utility index (0.68 ± 0.12 vs. 0.85 ± 0.11, p<0.05, and EQ-VAS (71.2 ± 12.3 vs. 83.9 ± 10.9, p<0.05. The differences remained (-0.05 for EQ-5D, -9.27 for EQ-VAS and -0.13 for SF-6D after controlling for socio-economic characteristics. SAQ scores showed that stable angina patients experienced impaired disease-specific health status, especially in angina stability (40.5 ± 34.6. Nested regressions indicated stable angina-specific health status explained most of the variation in HRQoL, among which disease perception, physical limitation, and angina stability were the strongest predictors. More physical exercise and better sleep were positively related with HRQoL. CONCLUSIONS: Compared to the general population, stable angina patients were associated with lower HRQoL and lower health utility scores, which were largely impacted by clinical symptoms

  17. The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study.

    Science.gov (United States)

    Papaioannou, A; Kennedy, C C; Ioannidis, G; Sawka, A; Hopman, W M; Pickard, L; Brown, J P; Josse, R G; Kaiser, S; Anastassiades, T; Goltzman, D; Papadimitropoulos, M; Tenenhouse, A; Prior, J C; Olszynski, W P; Adachi, J D

    2009-05-01

    Using prospective data from the Canadian Multicentre Osteoporosis Study (CaMos), we compared health utilities index (HUI) scores after 5 years of follow-up among participants (50 years and older) with and without incident clinical fractures. Incident fractures had a negative impact on HUI scores over time. This study examined change in health-related quality of life (HRQL) in those with and without incident clinical fractures as measured by the HUI. The study cohort was 4,820 women and 1,783 men (50 years and older) from the CaMos. The HUI was administered at baseline and year 5. Participants were sub-divided into incident fracture groups (hip, rib, spine, forearm, pelvis, other) and were compared with those without these fractures. The effects of both time and fracture type on HUI scores were examined in multivariable regression analyses. Men and women with hip fractures, compared to those without, had lower HUI measures that ranged from -0.05 to -0.25. Both women and men with spine fractures had significant deficits on the pain attributes (-0.07 to -0.12). In women, self-care (-0.06), mobility and ambulation (-0.05) were also negatively impacted. Women with rib fractures had deficits similar to women with spine fractures, and these effects persisted over time. In men, rib fractures did not significantly affect HUI scores. Pelvic and forearm fractures did not substantially influence HUI scores. The HUI was a sensitive measure of HRQL change over time. These results will inform economic analyses evaluating osteoporosis therapies.

  18. Transforaminal lumbar interbody fusion vs. posterolateral instrumented fusion

    DEFF Research Database (Denmark)

    Christensen, A; Høy, K; Bünger, C

    2014-01-01

    difference in either cost or effects although a tendency for the TLIF regimen being more costly on bed days (a,not sign2,554) and production loss (a,not sign1,915) was observed. The probability that TLIF would be cost-effective did not exceed 30 % for any threshold of willingness to pay per quality......Long-lasting low back pain is an increasing problem, and for some patients surgery is the final option for improvement. Several techniques for spinal fusion are available and the optimal technique remains uncertain. The objective of this study was to assess the cost-effectiveness and cost...... Index and SF-6D questionnaires. Conventional cost-effectiveness methodology was employed to estimate net benefit and to illustrate cost-effectiveness acceptability curves. The statistical analysis was based on means and bootstrapped confidence intervals. Results showed no statistically significant...

  19. Search for single production of vector-like quarks decaying into $Wb$ in $pp$ collisions at $\\sqrt{s} =$ 13 TeV with the ATLAS detector

    CERN Document Server

    The ATLAS collaboration

    2016-01-01

    A search for singly-produced vector-like quarks $Q$, where $Q$ can be either a $T$ quark with charge $2/3$ or a $Y$ quark with charge $4/3$, is performed in 3.2 $fb^{-1}$ of proton--proton collision data at a centre-of-mass energy of 13 TeV recorded with the ATLAS detector at the LHC. The analysis targets $Q \\to Wb$ decays where the $W$ boson decays leptonically. No significant excess over Standard Model backgrounds is observed and upper limits on the $Q \\to Wb$ cross-section times branching ratio are set as a function of the vector-like quark mass. For a $QWb$ coupling strength of $\\sqrt{(c_{\\mathrm{L}}^{Wb})^2 + (c_{\\mathrm{R}}^{Wb})^2 }=1/\\sqrt{2}$, the observed (expected) 95 % confidence level lower limit on the $Y$-quark mass is 1.44 TeV (1.45 TeV). The results are also interpreted as limits on the $QWb$ coupling strength and the mixing with the Standard Model sector for a singlet $T$ quark or a $Y$ quark from a $(B,Y)$ doublet. The smallest excluded coupling-strength values are obtained for vector-like ...

  20. Pyongyangi leedi Macbeth tõmbab niite Põhja-Koreas / Yuriko Koike

    Index Scriptorium Estoniae

    Koike, Yuriko

    2010-01-01

    Põhja-Korea liidri Kim Jong-il'i õest Kim Kyong-hui'st. Autori, Jaapani endise kaitseministri väitel on hakatud uskuma, et Kim Jong-il võib igal hetkel määrata just Kim Kyong-hui üleminekuaja valitsejaks, kes peab korraldama tema surma järel kolmanda põlvkonna Kimi võimuletuleku, kuid Kim Kyong-hui võib ise ihata saada Kim Jong-ili mantlipärijaks

  1. Measuring the impact of cataract surgery on generic and vision-specific quality of life.

    Science.gov (United States)

    Groessl, Erik J; Liu, Lin; Sklar, Marisa; Tally, Steven R; Kaplan, Robert M; Ganiats, Theodore G

    2013-08-01

    Cataracts are the leading cause of blindness worldwide and cause visual impairment for millions of adults in the United States. We compared the sensitivity of a vision-specific health-related quality of life (HRQOL) measure to that of multiple generic measures of HRQOL before and at 2 time points after cataract surgery. Participants completed 1 vision-specific and 5 generic quality of life measures before cataract surgery, and again 1 and 6 months after surgery. Random effects modeling was used to measure changes over the three assessment points. The NEI-VFQ25 total score and all 11 subscales showed significant improvements during the first interval (baseline and 1 month). During the second interval (1-6 months post-surgery), significant improvements were observed on the total score and 5 of 11 NEI-VFQ25 subscales. There were significant increases in HRQOL during the first interval on some preference-based generic HRQOL measures, though changes during the second interval were mostly non-significant. None of the SF-36v2™ or SF6D scales changed significantly between any of the assessment periods. The NEI-VFQ25 was sensitive to changes in vision-specific domains of QOL. Some preference-based generic HRQOL measures were also sensitive to change and showed convergence with the NEI-VFQ25, but the effects were small. The SF-36v2™ and SF-6D did not change in a similar manner, possibly reflecting a lack of vision-related content. Studies seeking to document both the vision-specific and generic HRQOL improvements of cataract surgery should consider these results when selecting measures.

  2. Sacroiliac joint pain: burden of disease

    Science.gov (United States)

    Cher, Daniel; Polly, David; Berven, Sigurd

    2014-01-01

    Objectives The sacroiliac joint (SIJ) is an important and significant cause of low back pain. We sought to quantify the burden of disease attributable to the SIJ. Methods The authors compared EuroQol 5D (EQ-5D) and Short Form (SF)-36-based health state utility values derived from the preoperative evaluation of patients with chronic SIJ pain participating in two prospective clinical trials of minimally invasive SIJ fusion versus patients participating in a nationally representative USA cross-sectional survey (National Health Measurement Study [NHMS]). Comparative analyses controlled for age, sex, and oversampling in NHMS. A utility percentile for each SIJ subject was calculated using NHMS as a reference cohort. Finally, SIJ health state utilities were compared with utilities for common medical conditions that were published in a national utility registry. Results SIJ patients (number [n]=198) had mean SF-6D and EQ-5D utility scores of 0.51 and 0.44, respectively. Values were significantly depressed (0.28 points for the SF-6D utility score and 0.43 points for EQ-5D; both P<0.0001) compared to NHMS controls. SIJ patients were in the lowest deciles for utility compared to the NHMS controls. The SIJ utility values were worse than those of many common, major medical conditions, and similar to those of other common preoperative orthopedic conditions. Conclusion Patients with SIJ pain presenting for minimally invasive surgical care have marked impairment in quality of life that is worse than in many chronic health conditions, and this is similar to other orthopedic conditions that are commonly treated surgically. SIJ utility values are in the lowest two deciles when compared to control populations. PMID:24748825

  3. Longitudinal beta regression models for analyzing health-related quality of life scores over time

    Directory of Open Access Journals (Sweden)

    Hunger Matthias

    2012-09-01

    Full Text Available Abstract Background Health-related quality of life (HRQL has become an increasingly important outcome parameter in clinical trials and epidemiological research. HRQL scores are typically bounded at both ends of the scale and often highly skewed. Several regression techniques have been proposed to model such data in cross-sectional studies, however, methods applicable in longitudinal research are less well researched. This study examined the use of beta regression models for analyzing longitudinal HRQL data using two empirical examples with distributional features typically encountered in practice. Methods We used SF-6D utility data from a German older age cohort study and stroke-specific HRQL data from a randomized controlled trial. We described the conceptual differences between mixed and marginal beta regression models and compared both models to the commonly used linear mixed model in terms of overall fit and predictive accuracy. Results At any measurement time, the beta distribution fitted the SF-6D utility data and stroke-specific HRQL data better than the normal distribution. The mixed beta model showed better likelihood-based fit statistics than the linear mixed model and respected the boundedness of the outcome variable. However, it tended to underestimate the true mean at the upper part of the distribution. Adjusted group means from marginal beta model and linear mixed model were nearly identical but differences could be observed with respect to standard errors. Conclusions Understanding the conceptual differences between mixed and marginal beta regression models is important for their proper use in the analysis of longitudinal HRQL data. Beta regression fits the typical distribution of HRQL data better than linear mixed models, however, if focus is on estimating group mean scores rather than making individual predictions, the two methods might not differ substantially.

  4. Health status has improved more in women than in men with rheumatoid arthritis from 1994 to 2009: results from the Oslo rheumatoid arthritis register.

    Science.gov (United States)

    Austad, C; Kvien, T K; Olsen, I C; Uhlig, T

    2015-01-01

    To examine changes in patient reported outcome measures (PROs) over 15 years in a representative population of patients with rheumatoid arthritis (RA), with a particular focus on gender differences. Patients in the Oslo RA register filled in questionnaires including the Modified Health Assessment Questionnaire (MHAQ), the Short-Form 36 (SF-36) with physical (PCS) and mental component summaries and derived utility (SF-6D), visual analogue scales (VAS) for pain, patient global assessment of disease (PtGA) and fatigue, and checklists of medication commonly used in the treatment of RA. Data were collected at five time points during a 15-year period from 1994. Mixed model analyses were used to analyse longitudinal changes in PROs from 1994 to 1996, 2001, 2004 and 2009. Data were available from 829-1025 RA patients at each time point. PROs were statistically significantly improved from 1994 to 2009 (MHAQ, SF-36 PCS, SF-6D, pain VAS, PtGA VAS and fatigue VAS; all p<0.001), and also with clinically important improvement. Men reported significantly better health status than women in 1994, but women improved significantly more than men over 15 years with a reduction of the gender gap in 2009. Antirheumatic medication was increasingly used over 15 years with no gender differences. RA patients reported statistically significantly improved health status for most PROs from 1994 to 2009. Women improved most, and although they still reported higher disease impact than men, the gender differences were small at the final data collection in 2009. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  5. Assessing utility where short measures are required: development of the short Assessment of Quality of Life-8 (AQoL-8) instrument.

    Science.gov (United States)

    Hawthorne, Graeme

    2009-09-01

    As researchers seek to include clinical outcomes, the health-related quality of life (HRQoL) of participants and meet economic evaluation demands, they are confronted with collecting disparate outcome data where parsimony is imperative. This study addressed this through construction of a short HRQoL measure, the Assessment of Quality of Life (AQoL)-8 from the original AQoL. Data from the AQoL validation database (N = 996) were reanalyzed using item response theory (IRT) to identify the least fitting items, which were removed. The standard AQoL scoring algorithm and weights were applied. Validity, reliability, and sensitivity tests were carried out using the 2004 South Australian Health Omnibus Survey (N = 3015), including direct comparisons with other short utility measures, the EQ5D and SF6D. The IRT analysis showed that the AQoL was a weak scale (Loevinger H = 0.36) but reliable (Mokken rho = 0.84). Removal of the four weakest items led to an 8-item instrument with two items per subscale, the AQoL-8. The AQoL-8 Loevinger H = 0.38 and Mokken rho = 0.80 suggested similar psychometric properties to the AQoL. It correlated (intraclass correlation coefficient) 0.95 (or 90% of shared variance) with the AQoL. The AQoL-8 was as sensitive to six common health conditions as the AQoL, EQ5D, and SF6D. The utility scores fall on the same life-death scale as those of the AQoL. Where parsimony is imperative, researchers may consider use of the AQoL-8 to collect participant self-report HRQoL data that is suitable for use either as reported outcomes or for the calculation of quality-adjusted life-years for cost-utility analysis.

  6. Exploring the Use of Cost-Benefit Analysis to Compare Pharmaceutical Treatments for Menorrhagia.

    Science.gov (United States)

    Sanghera, Sabina; Frew, Emma; Gupta, Janesh Kumar; Kai, Joe; Roberts, Tracy Elizabeth

    2015-09-01

    The extra-welfarist theoretical framework tends to focus on health-related quality of life, whilst the welfarist framework captures a wider notion of well-being. EQ-5D and SF-6D are commonly used to value outcomes in chronic conditions with episodic symptoms, such as heavy menstrual bleeding (clinically termed menorrhagia). Because of their narrow-health focus and the condition's periodic nature these measures may be unsuitable. A viable alternative measure is willingness to pay (WTP) from the welfarist framework. We explore the use of WTP in a preliminary cost-benefit analysis comparing pharmaceutical treatments for menorrhagia. A cost-benefit analysis was carried out based on an outcome of WTP. The analysis is based in the UK primary care setting over a 24-month time period, with a partial societal perspective. Ninety-nine women completed a WTP exercise from the ex-ante (pre-treatment/condition) perspective. Maximum average WTP values were elicited for two pharmaceutical treatments, levonorgestrel-releasing intrauterine system (LNG-IUS) and oral treatment. Cost data were offset against WTP and the net present value derived for treatment. Qualitative information explaining the WTP values was also collected. Oral treatment was indicated to be the most cost-beneficial intervention costing £107 less than LNG-IUS and generating £7 more benefits. The mean incremental net present value for oral treatment compared with LNG-IUS was £113. The use of the WTP approach was acceptable as very few protests and non-responses were observed. The preliminary cost-benefit analysis results recommend oral treatment as the first-line treatment for menorrhagia. The WTP approach is a feasible alternative to the conventional EQ-5D/SF-6D approaches and offers advantages by capturing benefits beyond health, which is particularly relevant in menorrhagia.

  7. Levonorgestrel-releasing intrauterine system vs. usual medical treatment for menorrhagia: an economic evaluation alongside a randomised controlled trial.

    Directory of Open Access Journals (Sweden)

    Sabina Sanghera

    Full Text Available OBJECTIVE: To undertake an economic evaluation alongside the largest randomised controlled trial comparing Levonorgestrel-releasing intrauterine device ('LNG-IUS' and usual medical treatment for women with menorrhagia in primary care; and compare the cost-effectiveness findings using two alternative measures of quality of life. METHODS: 571 women with menorrhagia from 63 UK centres were randomised between February 2005 and July 2009. Women were randomised to having a LNG-IUS fitted, or usual medical treatment, after discussing with their general practitioner their contraceptive needs or desire to avoid hormonal treatment. The treatment was specified prior to randomisation. For the economic evaluation we developed a state transition (Markov model with a 24 month follow-up. The model structure was informed by the trial women's pathway and clinical experts. The economic evaluation adopted a UK National Health Service perspective and was based on an outcome of incremental cost per Quality Adjusted Life Year (QALY estimated using both EQ-5D and SF-6D. RESULTS: Using EQ-5D, LNG-IUS was the most cost-effective treatment for menorrhagia. LNG-IUS costs £100 more than usual medical treatment but generated 0.07 more QALYs. The incremental cost-effectiveness ratio for LNG-IUS compared to usual medical treatment was £1600 per additional QALY. Using SF-6D, usual medical treatment was the most cost-effective treatment. Usual medical treatment was both less costly (£100 and generated 0.002 more QALYs. CONCLUSION: Impact on quality of life is the primary indicator of treatment success in menorrhagia. However, the most cost-effective treatment differs depending on the quality of life measure used to estimate the QALY. Under UK guidelines LNG-IUS would be the recommended treatment for menorrhagia. This study demonstrates that the appropriate valuation of outcomes in menorrhagia is crucial.

  8. The cost-effectiveness of group cognitive behavioral therapy compared with routine primary care for women with postnatal depression in the UK.

    Science.gov (United States)

    Stevenson, Matt D; Scope, Alison; Sutcliffe, Paul A

    2010-08-01

    To assess the cost-effectiveness of group cognitive behavior therapy (gCBT) in comparison with routine primary care for women with postnatal depression in the UK. Our analysis was based on a systematic literature review of the relative clinical effectiveness of gCBT compared with routine primary care and further reviews, supplemented with expert opinion of the likely cost of providing gCBT and the duration of comparative advantage for gCBT. Raw data were used to estimate a statistical relationship between changes in the Edinburgh Postnatal Depression Score (EPDS) values and changes in short-form six dimensions' (SF-6D) values. A mathematical model was constructed, and probabilistic sensitivity analyses were undertaken to estimate the mean cost per quality-adjusted life-year (QALY) and to evaluate the expected value of perfect information (EVPI). The mean cost per QALY from the stochastic analysis was estimated to be pound36,062; however, there was considerable uncertainty around this value. The EVPI was estimated to be greater than pound64 million; the key uncertainties were in the cost per woman of providing treatment and in the statistical relationship between changes in EPDS values and changes in SF-6D values. The expected value of perfect partial information for both of these parameters was in excess of pound25 million. Given the current information, the use of gCBT does not appear to be cost-effective; however, this decision is uncertain. The value of information analyses conducted indicates that further research to provide robust information on key parameters is needed and appears justified in cost-effective terms.

  9. Deriving common comorbidity indices from the MedDRA classification and exploring their performance on key outcomes in patients with rheumatoid arthritis.

    Science.gov (United States)

    Putrik, Polina; Ramiro, Sofia; Lie, Elisabeth; Michaud, Kaleb; Kvamme, Maria K; Keszei, Andras P; Kvien, Tore K; Uhlig, Till; Boonen, Annelies

    2018-03-01

    To develop algorithms for calculating the Rheumatic Diseases Comorbidity Index (RDCI), Charlson-Deyo Index (CDI) and Functional Comorbidity Index (FCI) from the Medical Dictionary for Regulatory Activities (MedDRA), and to assess how these MedDRA-derived indices predict clinical outcomes, utility and health resource utilization (HRU). Two independent researchers linked the preferred terms of the MedDRA classification into the conditions included in the RDCI, the CDI and the FCI. Next, using data from the Norwegian Register-DMARD study (a register of patients with inflammatory joint diseases treated with DMARDs), the explanatory value of these indices was studied in models adjusted for age, gender and DAS28. Model fit statistics were compared in generalized estimating equation (prediction of outcome over time) models using as outcomes: modified HAQ, HAQ, physical and mental component summary of SF-36, SF6D and non-RA related HRU. Among 4126 patients with RA [72% female, mean (s.d.) age 56 (14) years], median (interquartile range) of RDCI at baseline was 0.0 (1.0) [range 0-6], CDI 0.0 (0.0) [0-7] and FCI 0.0 (1.0) [0-6]. All the comorbidity indices were associated with each outcome, and differences in their performance were moderate. The RDCI and FCI performed better on clinical outcomes: modified HAQ and HAQ, hospitalization, physical and mental component summary, and SF6D. Any non-RA related HRU was best predicted by RDCI followed by CDI. An algorithm is now available to compute three commonly used comorbidity indices from MedDRA classification. Indices performed comparably well in predicting a variety of outcomes, with the CDI performing slightly worse when predicting outcomes reflecting functioning and health. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  10. Association between helplessness, disability, and disease activity with health-related quality of life among rheumatoid arthritis patients in a multiethnic Asian population.

    Science.gov (United States)

    Kwan, Yu Heng; Koh, Ee Tzun; Leong, Khai Pang; Wee, Hwee-Lin

    2014-08-01

    To investigate the association between helplessness, disability, and disease activity with health-related quality of life (HRQoL) in a multiethnic cohort of rheumatoid arthritis (RA) patients in Singapore. This cross-sectional study was conducted at Tan Tock Seng Hospital, Department of Rheumatology, Allergy and Immunology, from October 2010 to October 2011. All patients fulfilled the American College of Rheumatology 1987 criteria for RA. Socio-demographics, clinical, and patient-reported outcome (PRO) variables were collected. HRQoL outcomes were Short Form 36 (SF-36) physical and mental component summary (PCS and MCS) scores and Short Form 6 Dimensions (SF-6D) utilities. Stepwise multiple linear regression analyses were performed using HRQoL outcomes as dependent variables in separate models and with adjustment for helplessness (Rheumatology Attitudes Index, RAI), disability (Health Assessment Questionnaire, HAQ), and disease activity (Disease Activity in 28 joints) followed by socio-demographic, clinical, and PRO variables. Complete data were provided by 473 consenting subjects [mean (SD) age: 60.02 (11.04) years, 85 % female, 77 % Chinese]. After adjustment for all measured covariates, only RAI and HAQ scores remained significantly associated with SF-36 MCS (β: -0.9, p < 0.001; β: -7.0, p < 0.001) and SF-6D utilities (β: -0.005, p < 0.001; β: -0.081, p < 0.001), respectively, while only HAQ scores were significantly associated with SF-36 PCS (β: -7.7, p < 0.001). Interventions to address the sense of helplessness and to prevent or reduce disability could improve HRQoL of RA patients.

  11. Qualidade de vida em doentes com asma Quality of life in asthma patients

    Directory of Open Access Journals (Sweden)

    Lara Noronha Ferreira

    2010-01-01

    Full Text Available Neste artigo é descrito um estudo, cujo objectivo é a medição da qualidade de vida relacionada com a saúde (QdVRS de doentes com asma e a apresentação de uma primeira aproximação aos valores normativos, com base no SF-6D, para aquele tipo de doentes. Pretende-se ainda averiguar a capacidade de medidas genéricas de medição da QdVRS distinguirem grupos em termos de características sociodemográficas. Aplicaram-se, por entrevista pessoal, as versões portuguesas do EQ-5D, do SF-6D, do AQLQ(S e do ACQ a uma amostra representativa da população portuguesa com asma. A maioria dos indivíduos não apresentou problemas significativos nas dimensões medidas, excepto na função física, onde os indivíduos reportaram limitações moderadas. Em média, os inquiridos apresentam valores de utilidade de 0,86. Os homens, os mais jovens, os solteiros, os indivíduos com habilitações literárias mais elevadas, os empregados, os indivíduos com rendimentos mais elevados e aqueles que residiam em zonas urbanas foram os que reportaram níveis de utilidade mais elevados. Por outro lado, os indivíduos que se encontravam num estádio mais avançado da doença reportaram, como era de esperar, níveis médios de utilidade inferiores aos dos que se encontravam num estádio menos grave da doença. Foram obtidos valores normativos para o SF-6D para doentes com asma por género, grupo etário, estado civil, habilitações literárias, situação profissional, local de residência e rendimento médio mensal líquido. As medidas de utilidade baseadas em preferências utilizadas neste estudo discriminam adequadamente grupos de doentes com asma, de acordo com grupos sociodemográficos. Os valores normativos obtidos podem ser usados em estudos de avaliação económica e estudos clínicos, uma vez que incorporam as preferências dos doentes e traduzem a utilidade atribuída ao seu estado de saúde.In this paper we present a study whose main aim is the

  12. Koopia originaali ja camp'i vahel / Harry Liivrand

    Index Scriptorium Estoniae

    Liivrand, Harry, 1961-

    2001-01-01

    Brasiilia-ameerika fotograafi Vik Muniz'e (s. 1961 Brasiilias, elab USA-s) fotonäitus "Virtuoos, kellest sai fotograaf" Amsterdamis Huis Marseille's. Fotograaf reprodutseerib toiduainete, majapidamistarvete ja prahiga koopiaid kunstiteostest, mille hiljem pildistab

  13. Economics | Page 26 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les petites entreprises de pêche emploient aujourd'hui 50 des 51 millions ... Let us use these ideas to ensure that our reconstruction and development go ... Do regulations benefit the environment, and how do they affect industrial innovation?

  14. Virginia koolimõrvar oli tähelepandamatu / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    USA ajaloo ohvriterohkeima koolimõrva korraldas 23-aastane lõunakorealane Cho Seung-Hui, kes õppis Virginia tehnikaülikoolis. Lisad: Ohvriterohked koolitulistamised. Virginia tehnikaülikooli linnak

  15. The investigation of STEM Self-Efficacy and Professional ...

    African Journals Online (AJOL)

    Yi-hui Liu. Chung Hsiao Elementary School, Pingtung County, Taiwan ... STEM project-based learning, using social learning theory (SLT) and SCCT as the ..... platform can include media reports and videos about female engineer role models;.

  16. Pilk video homsesse päeva

    Index Scriptorium Estoniae

    2007-01-01

    Digivideo kipub uputama kogu internetti. Carnegie Melloni ülikooli IT-teadlase Hui Zhangi arvates võiksid päästerõngaks osutuda partnervõrgud. Artikkel üldpealkirja all: 10 tulevikutehnoloogiat 2007

  17. Thalassemia intermedia: An overview

    African Journals Online (AJOL)

    Rabah M. Shawky

    2012-04-25

    Apr 25, 2012 ... abnormalities occur due to massive expansion of erythroid bone marrow activity ..... [3] Savage D, Wood NAP, Bidwell JL, Fitches A, Old JM, Hui KM. Detection of b-thalassemia mutations using DNA heteroduplex generator ...

  18. Rembrandt Goethe kogust

    Index Scriptorium Estoniae

    1999-01-01

    Rembrandti majamuuseum Amsterdamis Rembrandt-Huis tähistab Johann Wolfgang von Goethe 250. sünniaastapäeva 18. juulini avatud 17. sajandi hollandi graafika väljapanekuga "Goethe ja Rembrandt. Joonistused Weimarist"

  19. Submicron Structures and Various Technology

    Science.gov (United States)

    1990-06-01

    Submitted by Professor Jonathan Allen Professor Daniel Kleppner !1! Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge, MA...Alberto Moel, Joyce E. Palmer, Samuel L. Park, Hui Meng Quek , John H.F. Scott-Thomas, Ghavam Shahidi, Siang-Chun The, Anthony Yen Undergraduate...substrates; and Kathleen Early, Reza A. Ghanbari, Yao-Ching Ku, periodic structures for x-ray optics, spectros- Alberto Moel, Hui Meng Quek , Dr. Mark L

  20. Imaging-based evaluation of liver function: comparison of {sup 99m}Tc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

    Energy Technology Data Exchange (ETDEWEB)

    Geisel, Dominik; Gebauer, Bernhard [Charite Campus Virchow-Klinikum, Department of Diagnostic and Interventional Radiology, Berlin (Germany); Luedemann, Lutz [Essen University Hospital, Department of Medical Physics, Essen (Germany); Froeling, Vera; Denecke, Timm [Charite Campus Virchow-Klinikum, Department of Diagnostic and Interventional Radiology, Berlin (Germany); Charite Campus Virchow-Klinikum, Department of Nuclear Medicine, Berlin (Germany); Malinowski, Maciej; Stockmann, Martin; Baron, Annekathrin; Seehofer, Daniel [Charite Campus Virchow-Klinikum, Department of General, Visceral and Thoracic Surgery, Berlin (Germany); Prasad, Vikas [Charite Campus Virchow-Klinikum, Department of Nuclear Medicine, Berlin (Germany)

    2015-05-01

    To compare Gd-EOB-enhanced MRI and {sup 99m}Tc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function. Fourteen patients underwent Gd-EOB-enhanced MRI and {sup 99m}Tc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T{sub max}, T{sub 1/2} and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL. Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r{sup 2} = 0.802, p = 0.001) and RE for LLL (r{sup 2} = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r{sup 2} = 0.560, p = 0.037) and RE for RLL (r{sup 2} = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r{sup 2} = 0.775, p = 0.002). Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and {sup 99m}Tc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function. (orig.)

  1. Cost Effectiveness of On-site versus Off-site Depression Collaborative Care in Rural Federally Qualified Health Centers

    Science.gov (United States)

    Pyne, Jeffrey M.; Fortney, John C.; Mouden, Sip; Lu, Liya; Hudson, Teresa J; Mittal, Dinesh

    2018-01-01

    Objective Collaborative care for depression is effective and cost-effective in primary care settings. However, there is minimal evidence to inform the choice of on-site versus off-site models. This study examined the cost-effectiveness of on-site practice-based collaborative care (PBCC) versus off-site telemedicine-based collaborative care (TBCC) for depression in Federally Qualified Health Centers (FQHCs). Methods Multi-site randomized pragmatic comparative cost-effectiveness trial. 19,285 patients were screened for depression, 14.8% (n=2,863) screened positive (PHQ9 ≥10) and 364 were enrolled. Telephone interview data were collected at baseline, 6-, 12-, and 18-months. Base case analysis used Arkansas FQHC healthcare costs and secondary analysis used national cost estimates. Effectiveness measures were depression-free days and quality-adjusted life years (QALYs) derived from depression-free days, Medical Outcomes Study SF-12, and Quality of Well Being scale (QWB). Nonparametric bootstrap with replacement methods were used to generate an empirical joint distribution of incremental costs and QALYs and acceptability curves. Results Mean base case FQHC incremental cost-effectiveness ratio (ICER) using depression-free days was $10.78/depression-free day. Mean base case ICERs using QALYs ranged from $14,754/QALY (depression-free day QALY) to $37,261/QALY (QWB QALY). Mean secondary national ICER using depression-free days was $8.43/depression-free day and using QALYs ranged from $11,532/QALY (depression-free day QALY) to $29,234/QALY (QWB QALY). Conclusions These results support the cost-effectiveness of the TBCC intervention in medically underserved primary care settings. Results can inform the decision about whether to insource (make) or outsource (buy) depression care management in the FQHC setting within the current context of Patient-Centered Medical Home, value-based purchasing, and potential bundled payments for depression care. The www.clinicaltrials.gov # for

  2. Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo.

    Science.gov (United States)

    Roux, Clémence; Saviane, Gaëlle; Pini, Jonathan; Belaïd, Nourhène; Dhib, Gihen; Voha, Christine; Ibáñez, Lidia; Boutin, Antoine; Mazure, Nathalie M; Wakkach, Abdelilah; Blin-Wakkach, Claudine; Rouleau, Matthieu

    2017-01-01

    Despite mesenchymal stromal cells (MSCs) are considered as a promising source of cells to modulate immune functions on cells from innate and adaptive immune systems, their clinical use remains restricted (few number, limited in vitro expansion, absence of a full phenotypic characterization, few insights on their in vivo fate). Standardized MSCs derived in vitro from human-induced pluripotent stem (huIPS) cells, remediating part of these issues, are considered as well as a valuable tool for therapeutic approaches, but their functions remained to be fully characterized. We generated multipotent MSCs derived from huiPS cells (huiPS-MSCs), and focusing on their immunosuppressive activity, we showed that human T-cell activation in coculture with huiPS-MSCs was significantly reduced. We also observed the generation of functional CD4 + FoxP3 + regulatory T (Treg) cells. Further tested in vivo in a model of human T-cell expansion in immune-deficient NSG mice, huiPS-MSCs immunosuppressive activity prevented the circulation and the accumulation of activated human T cells. Intracytoplasmic labeling of cytokines produced by the recovered T cells showed reduced percentages of human-differentiated T cells producing Th1 inflammatory cytokines. By contrast, T cells producing IL-10 and FoxP3 + -Treg cells, absent in non-treated animals, were detected in huiPS-MSCs treated mice. For the first time, these results highlight the immunosuppressive activity of the huiPS-MSCs on human T-cell stimulation with a concomitant generation of human Treg cells in vivo . They may favor the development of new tools and strategies based on the use of huiPS cells and their derivatives for the induction of immune tolerance.

  3. Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Clémence Roux

    2018-01-01

    Full Text Available Despite mesenchymal stromal cells (MSCs are considered as a promising source of cells to modulate immune functions on cells from innate and adaptive immune systems, their clinical use remains restricted (few number, limited in vitro expansion, absence of a full phenotypic characterization, few insights on their in vivo fate. Standardized MSCs derived in vitro from human-induced pluripotent stem (huIPS cells, remediating part of these issues, are considered as well as a valuable tool for therapeutic approaches, but their functions remained to be fully characterized. We generated multipotent MSCs derived from huiPS cells (huiPS-MSCs, and focusing on their immunosuppressive activity, we showed that human T-cell activation in coculture with huiPS-MSCs was significantly reduced. We also observed the generation of functional CD4+ FoxP3+ regulatory T (Treg cells. Further tested in vivo in a model of human T-cell expansion in immune-deficient NSG mice, huiPS-MSCs immunosuppressive activity prevented the circulation and the accumulation of activated human T cells. Intracytoplasmic labeling of cytokines produced by the recovered T cells showed reduced percentages of human-differentiated T cells producing Th1 inflammatory cytokines. By contrast, T cells producing IL-10 and FoxP3+-Treg cells, absent in non-treated animals, were detected in huiPS-MSCs treated mice. For the first time, these results highlight the immunosuppressive activity of the huiPS-MSCs on human T-cell stimulation with a concomitant generation of human Treg cells in vivo. They may favor the development of new tools and strategies based on the use of huiPS cells and their derivatives for the induction of immune tolerance.

  4. A parent-child dyad approach to the assessment of health status and health-related quality of life in children with asthma.

    Science.gov (United States)

    Ungar, Wendy J; Boydell, Katherine; Dell, Sharon; Feldman, Brian M; Marshall, Deborah; Willan, Andrew; Wright, James G

    2012-08-01

    Assessment of health state and health-related quality of life (HR-QOL) are limited by a child's age and cognitive ability. Parent-proxy reports are known to differ from children's reports. Simultaneous assessment using a parent-child dyad is an alternative approach. Our objective was to assess the validity, reliability and responsiveness of a parent-child dyad approach to utility and HR-QOL assessment of paediatric asthma health states. The setting was specialist care in a hospital-based asthma clinic. Participants were 91 girls and boys with asthma aged 8 to 17 years and 91 parents. The intervention employed was parent-child dyad administration of the Health Utilities Index (HUI) 2 and 3, the Pediatric Quality of Life Inventory™ (PedsQL™) Core and Asthma modules, and the Pediatric Asthma Quality of Life Questionnaire (PAQLQ). Questionnaires were administered by interview to children and parents separately and then together as a dyad to assess the child's health state. The dyad interview was repeated at the next clinic visit. Dyad-child agreement was measured by intra-class correlation (ICC) coefficient; Spearman correlations were used to assess convergent validity. Test-retest reliability was assessed in 28 children who remained clinically stable between visits with a two-way ICC coefficient. Responsiveness to change from baseline was assessed with Spearman coefficients in 30 children who demonstrated clinical change between visits. There was no significant agreement between parent and child for the HUI2 or HUI3 whereas agreement between dyad and child was 0.55 (95% confidence interval [CI] 0.36, 0.69) for the HUI2 and 0.74 (95% CI 0.61, 0.82) for the HUI3 overall. With respect to dyad performance characteristics, both HUI2 and HUI3 overall scores demonstrated moderate convergent validity with the generic PedsQL™ Core domains (range r = 0.30-0.52; p  0.4; p < 0.05) was observed for dyad HUI2 total score change over time as correlated with dyad

  5. Cadmium accumulation characteristics of low-cadmium rice (Oryza sativa L.) line and F1 hybrids grown in cadmium-contaminated soils.

    Science.gov (United States)

    Li, Kun; Yu, Haiying; Li, Tingxuan; Chen, Guangdeng; Huang, Fu

    2017-07-01

    Cadmium (Cd) pollution has threatened severely to food safety and human health. A pot experiment and a field experiment were conducted to investigate the difference of Cd accumulation between rice (Oryza sativa L.) lines and F 1 hybrids in Cd-contaminated soils. The adverse effect on biomass of rice lines was greater than that of F 1 hybrids under Cd treatments in the pot experiment. The variations of Cd concentration among rice cultivars in different organs were smaller in stem and leaf, but larger in root and ear. Average proportion of Cd in root of F 1 hybrids was 1.39, 1.39, and 1.16 times higher than those of rice lines at the treatment of 1, 2, and 4 mg Cd kg -1 soil, respectively. Cd concentrations in ear of F 1 hybrids were significantly lower than rice lines with the reduction from 29.24 to 50.59%. Cd concentrations in brown rice of all F 1 hybrids were less than 0.2 mg kg -1 at 1 mg Cd kg -1 soil, in which Lu98A/YaHui2816, 5406A/YaHui2816, and C268A/YaHui2816 could be screened out as cadmium-safe cultivars (CSCs) for being safe even at 2 mg Cd kg -1 soil. C268A/YaHui2816 showed the lowest Cd concentration in root among F 1 hybrids, while Lu98A/YaHui2816 and 5406A/YaHui2816 showed lower capability of Cd translocation from root to shoot under Cd exposure, which eventually caused the lower Cd accumulation in brown rice. The lower level of Cd translocation contributed to reducing the accumulation of Cd in brown rice had been validated by the field experiment. Thus, Lu98A/YaHui2816, 5406A/YaHui2816, and C268A/YaHui2816 could be considered as potential CSCs to cultivate in Cd-contaminated soils (<2 mg Cd kg -1 soil).

  6. AHP 40: Review: CHINA FROM EMPIRE TO NATION-STATE

    Directory of Open Access Journals (Sweden)

    Tristan G Brown

    2016-02-01

    Full Text Available Michael Gibbs Hill's excellent translation of the introduction to Wang Hui's four-volume opus, The Rise of Modern Chinese Thought 现代中 国思想的兴起 provides a substantial contribution to scholars of China and intellectual historians by bringing another of Wang Hui's critical works into English (for other such examples, see Wang and Huters 2003 and 2011. The task of translating could not have been easy, as Wang Hui frequently cites works from Chinese antiquity and translated texts from abroad, making Hill's results truly exceptional. The translation is accessible and painstakingly executed, with many important phrases explained for non-specialists alongside transliterated key terms. The Rise of Modern Chinese Thought demonstrates the need for translation work in the fields of area studies by making the important works of non-English speakers available to Anglophone audiences. As Zhang Yongle pointed out in his review on the work in toto, "It can safely be said that nothing comparable to Wang Hui's work has appeared in China since the late Qing-early Republican period" (Zhang 2010:71. Wang Hui, while exploring the links between China and its past through the country's rich intellectual traditions, manages to deftly discuss China in global terms and historical contexts. Hill's helpful introduction contextualizes Wang's writing style in the zeitgeist of the post Tiananmen period from 1990 to 2010. ...

  7. Sacroiliac joint pain: burden of disease

    Directory of Open Access Journals (Sweden)

    Cher D

    2014-04-01

    Full Text Available Daniel Cher,1 David Polly,2 Sigurd Berven31SI-BONE, Inc., San Jose, CA, USA; 2Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, USA; 3Department of Orthopedic Surgery, University of California San Francisco, San Francisco, CA, USAObjectives: The sacroiliac joint (SIJ is an important and significant cause of low back pain. We sought to quantify the burden of disease attributable to the SIJ.Methods: The authors compared EuroQol 5D (EQ-5D and Short Form (SF-36-based health state utility values derived from the preoperative evaluation of patients with chronic SIJ pain participating in two prospective clinical trials of minimally invasive SIJ fusion versus patients participating in a nationally representative USA cross-sectional survey (National Health Measurement Study [NHMS]. Comparative analyses controlled for age, sex, and oversampling in NHMS. A utility percentile for each SIJ subject was calculated using NHMS as a reference cohort. Finally, SIJ health state utilities were compared with utilities for common medical conditions that were published in a national utility registry.Results: SIJ patients (number [n]=198 had mean SF-6D and EQ-5D utility scores of 0.51 and 0.44, respectively. Values were significantly depressed (0.28 points for the SF-6D utility score and 0.43 points for EQ-5D; both P<0.0001 compared to NHMS controls. SIJ patients were in the lowest deciles for utility compared to the NHMS controls. The SIJ utility values were worse than those of many common, major medical conditions, and similar to those of other common preoperative orthopedic conditions.Conclusion: Patients with SIJ pain presenting for minimally invasive surgical care have marked impairment in quality of life that is worse than in many chronic health conditions, and this is similar to other orthopedic conditions that are commonly treated surgically. SIJ utility values are in the lowest two deciles when compared to control populations

  8. Measurement properties of ThyPRO short-form (ThyPRO-39) for use in Chinese patients with benign thyroid diseases.

    Science.gov (United States)

    Wong, Carlos K H; Choi, Edmond P H; Woo, Y C; Lang, Brian H H

    2018-04-18

    To evaluate the validity and reliability of a newly-translated Thyroid-specific Patient-Reported Outcome short-form (ThyPRO-39) instrument for ethnic-Chinese patients suffering from benign thyroid diseases. The translation and cross-cultural adaptation of the English ThyPRO-39 were performed using the double forward translation, reconciliation, single backward translation, and cognitive debriefing, followed by a panel review. Cross-sectional data of 308 patients with benign thyroid diseases were utilized for this psychometric evaluation of ThyPRO-39 instrument. Convergent validity between similar construct in the ThyPRO-39, SF-6D, and SF-12v2 was assessed using Spearman correlations. The internal construct validity was assessed by corrected item-total correlations. Sensitivity of the ThyPRO-39 domain scores was determined by performing known group comparisons by independent t test. The internal consistency reliability was assessed by Cronbach's alpha coefficient. Significant floor effects were observed in 9 out of 13 domains of the ThyPRO-39. The hypothesized correlations between similar constructs in the ThyPRO-39 and the SF-12v2 and SF-6D were generally observed, supporting convergent validity. The internal construct validity was supported in most items, except eight items in six scales. Scale score of hyperthyroid symptoms of the ThyPRO-39 was significantly higher in the group with Graves' disease or hyperthyroid disease than the group without Graves' disease nor hyperthyroid disease. Scale scores of eye symptoms and impaired daily life were significantly higher in the incidental group than the non-incidental group. For six domains (hyperthyroid symptoms, hypothyroid symptoms, eye symptoms, tiredness, depressivity, and emotional susceptibility), Cronbach's alpha did not reach the recommended standard of 0.7. This was the first psychometric study to translate and adapt the ThyPRO-39 instrument for non-Caucasian patients, and report its validity and reliability

  9. C-C4-02: Improving Survivorship Care for Long-Term Colorectal Cancer Survivors: Key Findings of a 5-Year Study

    Science.gov (United States)

    McMullen, Carmit K; Hornbrook, Mark C; Herrinton, Lisa J; Altschuler, Andrea; Grant, Marcia; Wendel, Christopher; Coons, Stephen Joel; Green, Sylvan B; Mohler, M Jane; Baldwin, Carol M; Ramirez, Michelle; Krouse, Robert S

    2010-01-01

    Aims: Understand the determinants of health related quality of life (HRQOL) and the lived experiences among colorectal cancer (CRC) survivors, and identify strategies to help maintain or enhance CRC survivors’ HRQOL. Methods: Mail survey and focus groups. Subjects were 283 ostomy and 392 anastomosis long-term CRC survivors within an HMO. Focus groups for subjects with ostomy were divided by gender and high and low HRQOL. Outcome measures were the modified City of Hope Quality of Life (mCOH-QOL)-Ostomy (abridged for anastomosis) and SF-36v2 questionnaires. The SF-6D scoring algorithm was used to calculate an overall HRQOL score from SF-36v2 data. Focus groups were conducted to explore ostomy-related barriers to effective self-care and adaptation strategies. Results: CRC survivors with an ostomy experienced multiple persistent HRQOL losses that differ between men and women. Women CRC survivors with ostomies, for example, reported more sleep disruption and fatigue than men. Living with an ostomy, co-morbidities, socioeconomic status, self-reported depression, and employment status were independent predictors of SF-6D scores. Among CRC survivors with ostomy, fistulas had important implications for HRQOL. Psychological wellbeing among CRC survivors was positively associated with income. Intestinal stomas significantly influenced spiritual HRQOL. Provision or withdrawal of a partners’ support affected both short- and long-term psychosocial adjustment of female CRC ostomy patients. Focus group participants identified dietary changes to control bowel output and odor, demands of coping and adjustment, and the time it took to accept the reality of daily living with an ostomy as significant challenges. Conclusions: The greatest challenges reported by CRC survivors confirmed the IOMs findings that survivorship is a distinct, chronic phase of cancer care, and that cancer effects are broad and pervasive. CRC survivors could benefit from dietary and behavioral interventions

  10. A comparison of the relationships between psychosocial factors, occupational strain, and work ability among 4 ethnic teacher groups in China.

    Science.gov (United States)

    Lian, Yulong; Xiao, Jing; Zhang, Chen; Guan, Suzhen; Li, Fuye; Ge, Hua; Liu, Jiwen

    2016-01-01

    The present study compared the level of occupational strain and work ability among Han, Hui, Uygur, Hui, and Kazakh teachers, and explored ethnic differences based on the associations of psychosocial factors at work, occupational strain, and work ability. A cross-sectional survey was conducted among 2,941 teachers in primary and secondary schools in Xinjiang Province, China. Psychosocial factors, occupational strain, and work ability were measured using the Occupation Stress Inventory-Revised Edition (OSI-R) and Work Ability Index. Han and Hui teachers experienced reduced work ability compared with Uygur and Kazakh teachers, and this finding was caused, in part, by exposure to psychosocial factors at work. The vocational and psychological strains caused by these factors play an important role in reduced work ability among all ethnic teacher groups. The findings indicate the importance of taking action to reduce occupational strain for promoting teachers' work ability in multiethnic workplaces.

  11. Adaptação, estabilidade e potencial produtivo de genótipos de Triticum durum L., irrigados por aspersão, no Estado de São Paulo Adaptability, stability and yield potential of Triticum durum L. genotypes under sprinkler irrigation in the State of São Paulo

    Directory of Open Access Journals (Sweden)

    João Carlos Felicio

    2005-01-01

    Full Text Available Avaliaram-se 17 linhagens e duas cultivares de Triticum durum L. tendo como testemunha a cultivar IAC 24 de T. aestivum L., em experimentos semeados em condições de irrigação por aspersão nas localidades de Votuporanga, Ribeirão Preto e Mococa, no período de 1998 a 2002, no Estado de São Paulo. Foram determinados os rendimentos de grãos e o comportamento de cada genótipo diante das variações ambientais. Análises de adaptação e estabilidade permitiram a identificação de genótipos com comportamento previsível a essas condições ambientais. Foram observados efeitos significativos para anos, locais e genótipos, destacando-se na média dos três locais quanto ao rendimento de grãos a linhagem de T. durum L. 11 (MEMOS"S"/YAV79/3/ SAPI"S"/TEAL"S"// HUI"S". O melhor rendimento de grãos foi observado em Ribeirão Preto e o pior em Votuporanga. Observou-se nas linhagens 9 e 11 (MEMOS"S"/YAV79/3/SAPI"S"/TEAL"S"//HUI"S, 12 e 19 (GYS"S"/3/ STN"S"// HUI"S"/SOMOS"S" e 3 (STN"S"/3/TEZ"S"/YAV79// HUI"S" adaptabilidade específica, portanto, responsivas ao emprego de alta tecnologia. A incidência da ferrugem-da- folha somente foi constatada na cultivar IAC 24 da espécie de T. aestivum.In order to evaluate Triticum durum L. genotypes having as control the T. aestivum L. cultivar IAC, 24 experiments were carried out, under sprinkler irrigation, at Votuporanga, Ribeirão Preto and Mococa locations, in the period 1998 to 2002, in the State of São Paulo. Grain yield and performance of each genotype in relation to the environment variation were evaluated. Adaptability and stability analysis were made identify genotypes with predictable performance in these environment conditions. Significant effects were observed for years, locations and genotypes. Considering the three locations, Triticum durum inbred line 11 (MEMOS"S"/YAV79/3/ SAPI"S"/TEAL"S"// HUI"S" presented the highest yield. The highest grain yields were observed in Ribeirão Preto and

  12. L'évolution des valeurs de soin humain : une analyse dialectique de la proposition d'humanisation de Watson à la lumière d'une perspective nietzschéenne

    OpenAIRE

    Krol, Pawel

    2014-01-01

    La pratique du soin infirmier d’aujourd’hui hérite d’une longue et complexe évolution de valeurs. Outre les valeurs traditionnellement humaines de soigner, la pratique infirmière d’aujourd’hui intègre aussi des valeurs qui façonnent notre monde moderne. Ainsi, nous retraçons d’abord l’évolution de quelques-unes des valeurs traditionnelles rattachées au soin humain conservées dans les pratiques infirmières. Puis, nous montrons que certaines valeurs traditionnelles de soin humain sont progressi...

  13. Ageing Mechanisms and Control. Specialists’ Meeting on Life Management Techniques for Ageing Air Vehicles (Les mecanismes vieillissants et le controle) (Reunions des specialistes des techniques de gestion du cycle de vie pour vehicules aeriens vieillissants)

    Science.gov (United States)

    2003-02-01

    Synthèse Aujourd’hui, les chefs militaires de l’ensemble des pays membres de l’OTAN constatent que leurs flottes d’aéronefs sont maintenues en exploitation...problems and, where possible, the investment required for attaining the needed capability. Thème Aujourd’hui, les chefs militaires de l’ensemble des pays...25.13091 identifies risk requirements and its companion Advisory Circular (AC 25.1309) interprets those requirements as the familiar 10-9 probability

  14. Vers une tarification plate dans le Rhône. Enjeux, limites et perspectives de la restructuration tarifaire sur les lignes régulières départementales

    OpenAIRE

    Peggy Durand

    2007-01-01

    Les questions de mobilité au sein des grands bassins de vie et entre les aires urbaines occupent aujourd'hui une place majeure dans les réflexions politiques, notamment à l'échelle départementale. La loi d'Orientation sur les Transports Intérieurs (LOTI) de 1982 a confirmé la compétence des Départements dans la planification et l'organisation des transports collectifs non-urbains de personnes (Art 29). Autorités organisatrices, ils ont aujourd'hui la charge de définir l'offre et les dispositi...

  15. Pataphysique de la menace.

    Directory of Open Access Journals (Sweden)

    Nicolas Tavaglione

    2008-04-01

    Full Text Available Alors qu’on la croyait morte il y a à peine vingt ans, la gauche radicale forme pourtant aujourd’hui une galaxie vive et bouillonnante. « De l’extrême-gauche classique à l’altermondialisation », comme l’écrit Philippe Raynaud, la scène politique française fourmille aujourd’hui d’acteurs nourrissant « l’ambition de définir une “autre politique” en rupture avec le consensus libéral ou avec les formes actuelles de la mondialisation » (Raynaud, 2006 ...

  16. Examining the incremental impact of long-standing health conditions on subjective well-being alongside the EQ-5D.

    Science.gov (United States)

    Wu, Mengjun; Brazier, John; Relton, Clare; Cooper, Cindy; Smith, Christine; Blackburn, Joanna

    2014-04-29

    Generic preference-based measures such as the EQ-5D and SF-6D have been criticised for being narrowly focused on a sub-set of dimensions of health. Our study aims to explore whether long-standing health conditions have an incremental impact on subjective well-being alongside the EQ-5D. Using data from the South Yorkshire Cohort study (N = 13,591) collected between 2010 and 2012 on the EQ-5D, long-standing health conditions (self-reported), and subjective well-being measure--life satisfaction using a response scale from 0 (completely dissatisfied) to 10 (completely satisfied), we employed generalised logit regression models. We assessed the impact of EQ-5D and long-standing health conditions together on life satisfaction by examining the size and significance of their estimated odds ratios. The EQ-5D had a significant association with life satisfaction, in which anxiety/depression and then self-care had the largest weights. Some long-standing health conditions were significant in some models, but most did not have an independent impact on life satisfaction. Overall, none of the health conditions had a consistent impact on life satisfaction alongside the EQ-5D. Out study suggests that the impact of long-standing health conditions on life satisfaction is adequately captured by the EQ-5D, although the findings are limited by reliance on self-reported conditions and a single item life satisfaction measure.

  17. Occupational stress is associated with impaired work ability and reduced quality of life in patients with chronic kidney failure.

    Science.gov (United States)

    Neri, Luca; Rocca Rey, Luisa A; Gallieni, Maurizio; Brancaccio, Diego; Cozzolino, Mario; Colombi, Antonio; Burroughs, Thomas E

    2009-05-01

    About 300,000 patients in the United States with Chronic Kidney Failure (CKF) are of working age, but up to 70% lose their job within the first year of renal replacement therapy .No study has examined how work ability and perceived health are influenced by the subjects' adjustment to their job. We assessed the association of occupational stress (Effort-Reward Imbalance, ERI),work ability (WAI) and health-related quality of life (QoL) in hemodialysis. 40 employed hemodialysis patients completed a self-administered questionnaire. Associations between ERI, short Form 12 (sF-12), short Form - 6 Dimensions (sF-6D), Kidney Disease QOL- 36 (KDQOL-36) and WAI were tested with partial Spearman's correlation adjusted for age, income, and comorbidity burden. Study subjects were mainly low-income (82%), african-american (73%), men (75%); 16 were manual laborers and 9 worked in the industrial sector. Study subjects reported low levels of Occupational Stress: ERI scores indicated an imbalance between Job Efforts and Rewards in only 3 subjects. Nevertheless, ERI scores were inversely and strongly associated with WAI (rho=-0.41, pworking. The causal relationship between Occupational stress, perceived health, and work ability should be further investigated. Occupational Health professionals and nephrologists should closely collaborate to meet the needs of occupationally active hemodialysis patients.

  18. A cost-utility analysis of psychoanalysis versus psychoanalytic psychotherapy.

    Science.gov (United States)

    Berghout, Caspar C; Zevalkink, Jolien; Hakkaart-van Roijen, Leona

    2010-01-01

    Despite the considerable and growing body of research about the clinical effectiveness of long-term psychoanalytic treatment, relatively little attention has been paid to economic evaluations, particularly with reference to the broader range of societal effects. In this cost-utility study, we examined the incremental cost-effectiveness ratio (ICER) of psychoanalysis versus psychoanalytic psychotherapy. Incremental costs and effects were estimated by means of cross-sectional measurements in a cohort design (psychoanalysis, n = 78; psychoanalytic psychotherapy, n = 104). Quality-adjusted life-years (QALYs) were estimated for each treatment strategy using the SF-6D. Total costs were calculated from a societal perspective (treatment costs plus other societal costs) and discounted at 4 percent. Psychoanalysis was more costly than psychoanalytic psychotherapy, but also more effective from a health-related quality of life perspective. The ICER--that is, the extra costs to gain one additional QALY by delivering psychoanalysis instead of psychoanalytic psychotherapy--was estimated at 52,384 euros per QALY gained. Our findings show that the cost-utility ratio of psychoanalysis relative to psychoanalytic psychotherapy is within an acceptable range. More research is needed to find out whether cost-utility ratios vary with different types of patients. We also encourage cost-utility analyses comparing psychoanalytic treatment to other forms of (long-term) treatment.

  19. North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A Second Year Assessment

    Science.gov (United States)

    2014-03-01

    Kim Kyong-hui was critically ill. Kim has a reported history of alcoholism and depression , which was exacerbated in the mid-2000s with her mari- tal...problems and the death of her daughter, Jang Kum-song, who com- mitted suicide in 2006. Some reports claim that she is also suffering from... teens , were

  20. Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects

    NARCIS (Netherlands)

    Peter T. Theunissen; Bruce Beyer; Sonia Beken

    2016-01-01

    And co-authors William J. Breslin, Gregg D. Cappon, Connie L. Chen, Gary Chmielewski, Luc de Schaepdrijver, Brian Enright, Jennifer E. Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M. Hoberman, Julia Y. Hui, Thomas B. Knudsen, Susan B. Laffan, Susan L. Makris, Matthew Martin, Mary Ellen McNerney,

  1. 读书(英文)

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    1 A Kaleidoscope of Chinese Culture《中华文化趣谈》Compiler:Zhang Yajun(Translated by Guo Hui) Publisher:Sinolingua Press This book introduces the important aspects of traditional Chinese culture,in 14 topics,including Chinese characters,numbers,animals, plants,colors,food,festivals,names and cross-cultural communication.

  2. Evaluation of effectiveness in a novel wound healing ointment ...

    African Journals Online (AJOL)

    Evaluation of effectiveness in a novel wound healing ointment-crocodile oil burn ointment. Hua-Liang Li, Yi-Tao Deng, Zi-Ran Zhang, Qi-Rui Fu, Ya-Hui Zheng, Xing-Mei Cao, Jing Nie, Li-Wen Fu, Li-Ping Chen, You-Xiong Xiong, Dong-Yan Shen, Qing-Xi Chen ...

  3. Multiple proteins of White spot syndrome virus involved in ...

    Indian Academy of Sciences (India)

    Author Affiliations. Jing-Yan Zhang1 2 Qing-Hui Liu1 Jie Huang1. Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, P. R. China; Shanghai Ocean University, 999 Hucheng Ring Road, Pudong, Shanghai, China ...

  4. Biisofraxidin on Apoptosis of Human Gastric Cancer BGC-823 Cells

    African Journals Online (AJOL)

    Wu et al. Trop J Pharm Res, October 2015; 14(10): 1803. Tropical Journal of Pharmaceutical Research ... Jian-Tao Wu1,2*, She-Min Lv1, Chun-Hui Lu1, Jun Gong1 and Jian-Bo An3 ..... Zhu AK, Zhou H, Xia JZ, Jin HC, Wang K, Yan J, Zuo JB,.

  5. Tropical Journal of Pharmaceutical Research - Vol 15, No 3 (2016)

    African Journals Online (AJOL)

    Wan Wu, Wei Chen, Qiong Jin, 447-451 ... Chung-Shih Chen, Mei-Lin Wang, Rosa Huang Liu, Shih-Pin Chen, Tsong-Ming Lu, Wei-Yu Tsai, Chien-Fu Huang, ... Yan-Qiong Li, Rui Hu, Li-Hui Zhong, Qian Sun, You-Ping Yan, 527-533.

  6. Turkse en Marokkaanse Nederlanders thuis

    NARCIS (Netherlands)

    Dibbits, H.; Horst, van der H.M.

    2007-01-01

    Veel Nederlanders hebben misschien een Turkse waterpijp of Marokkaanse theeglaasjes in huis, maar de meeste mensen hebben er geen idee van hoe het er bij Turkse en Marokkaanse Nederlanders thuis uitziet. Dit boek brengt hier verandering in. In twee rijk geïllustreerde en toegankelijk geschreven

  7. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Synthesis and bio-catalytic activity of isostructural cobalt(III)-phenanthroline complexes. Dhananjay Dey Arnab Basu Roy Anandan Ranjani Loganathan Gayathri Saravanan Chandraleka Dharumadurai Dhanasekaran Mohammad Abdulkader Akbarsha Chung-Yu Shen Hui-Lien Tsai Milan Maji Niranjan Kole Bhaskar ...

  8. Flore vasculaire rare et endemique de la peninsule de l'Edough ...

    African Journals Online (AJOL)

    sous le nom de« biodiversity hotspots» [2]. La flore du bassin mediterraneen est aujourd'hui tres serieusement menacee, en raison de la forte regression des milieux naturels sous l' action de l 'homme, mais aussi parce que cette region serait l'une des plus exposees aux changements climatiques globaux [3-5]. Cette flore ...

  9. N HERSIENING VAN DIE AFRIKAANSE VERTALING VAN DIE ...

    African Journals Online (AJOL)

    Test

    aangetoon het, 'n huis in Kapernaum gehad en hierdie geskiedenis speel in Kapernaum of daar digby af. Jesus en sy dissipele het namelik, volgens 6:35 geland by Gennesaret, net suid van Kapernaum Die gevolgtrekking word ondersteun deur Joh. 6:17 waarvolgens die dissi pele na die spysiging op Kapernaum gevaar ...

  10. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Haiyang Dai1 Changyong Zhan2 Hui Jiang2 Ningkang Huang2. Department of Technology and Physics, Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China; Key Laboratory of Radiation and Technology of Education Ministry of China, Institute of Nuclear Science and Technology, Sichuan University, ...

  11. High utility-itemset mining and privacy-preserving utility mining

    Directory of Open Access Journals (Sweden)

    Jerry Chun-Wei Lin

    2016-03-01

    Full Text Available In recent decades, high-utility itemset mining (HUIM has emerging a critical research topic since the quantity and profit factors are both concerned to mine the high-utility itemsets (HUIs. Generally, data mining is commonly used to discover interesting and useful knowledge from massive data. It may, however, lead to privacy threats if private or secure information (e.g., HUIs are published in the public place or misused. In this paper, we focus on the issues of HUIM and privacy-preserving utility mining (PPUM, and present two evolutionary algorithms to respectively mine HUIs and hide the sensitive high-utility itemsets in PPUM. Extensive experiments showed that the two proposed models for the applications of HUIM and PPUM can not only generate the high quality profitable itemsets according to the user-specified minimum utility threshold, but also enable the capability of privacy preserving for private or secure information (e.g., HUIs in real-word applications.

  12. In Pursuit of Islamic "Authenticity": Localizing Muslim Identity on China's Peripheries

    Directory of Open Access Journals (Sweden)

    Lesley Turnbull

    2014-09-01

    Full Text Available In this ethnographic sketch, I analyze the complex processes of Sino-Islamic identity formation by examining the variety and diversity of locally produced “authenticity,” situated within a global understanding of Islam. Even within a single province, among a single official minzu (nationality that People’s Republic of China propaganda, media, and scholarship often construct as a unified, static group, localized practices and processes of identity formation are remarkably diverse. This article investigates how trans/national discourses and practices of Islamic authenticity are localized within two specific field sites: the provincial capital of Kunming and the rural Muslim enclave of Shadian. For the purposes of this article, I focus primarily on how life is temporally and spatially structured, both in everyday practice and in imaginings of one’s place in history, modernity, the Muslim world, and the Chinese state. By setting out details of the daily lives of two Hui Muslim women, I aim to elucidate how temporal and spatial structures of life, which are tied to urban or rural location, reflect and shape local identity formation. I argue that as actors involved in their own self-production, Hui Muslims in Kunming and Shadian negotiated, appropriated, and contested both monolithic notions of Islam and the official state-propagated minzu classificatory system, producing their own versions of authentic Hui Muslim identities. What constituted authentic Hui Muslim identity depended to a great extent on the residence of the individual.

  13. Het Boschstraatkwartier-Oost circa 1900: wonen en werken onder de rook van Sphinx

    NARCIS (Netherlands)

    Drs. Thijs van Vugt

    2006-01-01

    De italiaanse historicus Gribaudi heeft enkele generaties arbeiders in Turijn in de eerste helft van de twintigste eeuw onderzocht. Hij analyseert onder andere de herkomst (terug tot het platteland) en verdere ontwikkeling van 48 families die in 1936 een huis bewonen in de arbeidersbuurt Madonna de

  14. A Home of Their Own

    NARCIS (Netherlands)

    M.H. Kwekkeboom; A.H. de Boer; C. van Campen; A. Dorrestein

    2006-01-01

    Original title: Een eigen huis... Not all people with a learning disability or long-term psychiatric problems live in an institution hidden away deep in the woods. Increasingly, they live in an ordinary house in an ordinary neighbourhood and lead an independent existence. The idea is that this

  15. Online in opkomst: eten kopen in de winkel wordt een keuze

    NARCIS (Netherlands)

    Haaster-de Winter, van M.A.

    2015-01-01

    Consumenten hoeven hun huis niet meer uit. Binnen een paar muisklikken zijn de boodschappen besteld. Dat kan relatief gemakkelijk. De online infrastructuur in Nederland is goed; de internetpenetratie is één van de hoogste binnen Europa (>90%). Het percentage mensen dat min of meer dagelijks het

  16. AcEST: DK962421 [AcEST

    Lifescience Database Archive (English)

    Full Text Available den, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J....t BLASTX 2.2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jing...hui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and

  17. AcEST: DK952372 [AcEST

    Lifescience Database Archive (English)

    Full Text Available den, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J....t BLASTX 2.2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jing...hui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and

  18. AcEST: BP920873 [AcEST

    Lifescience Database Archive (English)

    Full Text Available e: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, a...t BLASTX 2.2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jing...hui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), Gapped BLAST and

  19. Psychological Aspects of Geographical Moves. Homesickness and Acculturation Stress

    NARCIS (Netherlands)

    Tilburg, van Miranda; Vingerhoets, Ad

    2005-01-01

    'Het is de verdienste van dit boek dat op uitgebreide wijze aandacht wordt geschonken aan het feit dat lang niet iedereen zonder problemen huis en haard achterlaat. De samenstellers hebben gelijk dat hier sprake is van een onderbelicht probleem of wellicht zelfs een taboe.' Jan Spijker, Maandblad

  20. Miscellaneous information

    NARCIS (Netherlands)

    NN,

    1969-01-01

    Taiwan herbaceous flora (see Fl.Mal.Bull. 22, p. 1562). In 1968 Prof. Hui-Lin Li spent a considerable time in Taiwan discussing this project with Taiwan botanists and authorities. An agreement was finally reached among those who are to be actively participating and a plan of procedure and a budget

  1. Research Article

    African Journals Online (AJOL)

    1 janv. 2017 ... Département des sciences de l'eau, Université de Blida, 09000 Blida, Algérie. Received: 17 .... la superficie agricole de la plaine d'Ouakda était de 281 Ha [7]. Aujourd'hui cette ..... des engrais biologiques ou chimiques.

  2. Association between vitamin D receptor gene polymorphism (TaqI ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 94; Issue 3. Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. Hui-Ru Fan Li-Qun Lin Hao Ma Ying Li Chang-Hao Sun. Research Note Volume 94 Issue 3 September 2015 pp 473-478 ...

  3. AUTHOR INDEX

    Indian Academy of Sciences (India)

    microscopic techniques for imaging cell ... Q-switched Yb-doped photonic crystal fibre laser ... Classical simulations of heavy-ion fusion .... functionalized graphene ... Li Hui-Jia see Hu Ke. 571. Lin Huini. Finite-time synchronization of a class of.

  4. Anti-depressant effect of Paeonia lactiflora Pall extract in rats

    African Journals Online (AJOL)

    Anti-depressant effect of Paeonia lactiflora Pall extract in rats. Xiao-hui ... PLPE, at a dose ≥ 150 mg/kg significantly inhibited MAO A activity in rat whole brain in a dose-dependent manner .... (pH 7.4) upto a final volume of 1 ml. The reaction.

  5. DVD-d. Shrek Kolmas; Ma olen legend / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2008-01-01

    Lühiarvustused USA 2007.a. filmidele : animafilm "Shrek Kolmas" ("Shrek the Third", režissöörid Chris Miller, Raman Hui) ja ulmefilm "Ma olen legend" ("I Am Legend"; režissöör Francis Lawrence)

  6. Book Reviews.

    Science.gov (United States)

    Coates, Elizabeth; And Others

    1993-01-01

    Reviews three books: (1) "Jeux Populaires Traditionnels pour les Enfants d'aujourd'hui" (Traditional Popular Games for Today's Children) (Jacqueline Theriault and Denise Garon); "Early Childhood Education" (B. Persky and L. Golubchick, editors); and "Playing to Learn: The Young Child, Teacher and the Classroom" (Weininger and Daniel). (AC)

  7. Le point sur les indices du bien-être national | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    21 janv. 2011 ... Aujourd'hui, de nouveaux indices perfectionnés tracent un portrait plus fouillé de l'état ... des progrès sur le plan économique, mais beaucoup de citoyens ne profitent pas de .... Tobacco Marketing — It's All Smoke and Mirrors.

  8. Cultures et organisations

    NARCIS (Netherlands)

    Hofstede, G.; Hofstede, G.J.; Minkov, M.

    2010-01-01

    La coopération interculturelle, une question de survie Véritable atlas des valeurs culturelles, paru en 18 langues, Cultures et organisations est le fruit de plus de 40 ans de recherches menées dans plus de 100 pays. Il est aujourd'hui le livre de référence des chercheurs, universitaires et

  9. Dictionaries compiled with French and

    African Journals Online (AJOL)

    Information Technology

    constitue l'un des problèmes fondamentaux des lexicographes aujourd'hui. Quelle est la nature des .... first time by the Imprimerie de la Libre Lorraine in Metz (1930–1934). It is monoscopal, with ..... Python de Seba. Python sebae. Serval.

  10. Theoretical Construction of Freedom and Pluralism Education in Pastoral Areas

    Science.gov (United States)

    Zhao, Shuyan

    2009-01-01

    At beginning of the article, the author has a brief introduction of basic conditions in pastoral areas of Imperial Town, and interprets ethnic relations among Han, Tibetan, Mongolian, Yugur, Hui, Manchu and Tu mixed residence. After analysis of the internal and external factors that affect the specificity of pastoral education, the author…

  11. Ontwikkelingen in Foodservice : online en beleving creëren nieuwe kansen voor toeleveranciers van agf

    NARCIS (Netherlands)

    Splinter, G.M.; Haaster-de Winter, van M.A.

    2015-01-01

    Het voedsellandschap is in beweging. Een ontwikkeling met grote gevolgen voor “vers” en haar toeleveranciers. Voedsel is op steeds meer (verschillende) plaatsen te koop en wordt aangeboden door verschillende aanbieders. GroentenFruit Huis wil de groenten- en fruitsector versterken en de positie van

  12. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. Philip N Garner. Articles written in Sadhana. Volume 36 Issue 5 October 2011 pp 885-915. Current trends in multilingual speech processing · Hervé Bourlard John Dines Mathew Magimai-Doss Philip N Garner David Imseng Petr Motlicek Hui Liang Lakshmi Saheer Fabio Valente · More Details ...

  13. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Xing Hui Zhang1 Fu Long Zhang1 Zhi Yuan Geng2. College of Chemical Engineering, Gansu Lianhe University, Lanzhou 730010, P.R. China; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, P.R. China ...

  14. Le combat contre le tabagisme à l'échelle mondiale | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 janv. 2011 ... ... en effet d'adopter la toute première convention mondiale à porter sur un enjeu de la santé. ... Elle a désormais force de loi dans plus de 40 pays, dont le Canada. ... ce taux est passé de 1 % il y a dix ans à 5 % aujourd'hui.

  15. Publications | Page 2 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Documentaire sur des solutions locales qui permettent d'offrir plus de possibilités d'emploi aux femmes au Rwanda. Quand Nyirangaruye Dancilla a perdu son mari, elle s'est tournée vers la production de vin de banane pour ne pas se retrouver sans ressources. Aujourd'hui, les revenus de cette entreprise permettent à ...

  16. Publications | Page 6 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Documentaire sur des solutions locales qui permettent d'offrir plus de possibilités d'emploi aux femmes au Rwanda. Quand Nyirangaruye Dancilla a perdu son mari, elle s'est tournée vers la production de vin de banane pour ne pas se retrouver sans ressources. Aujourd'hui, les revenus de cette entreprise permettent à ...

  17. Reference: 197 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available bidopsis thaliana CAX2 cation transporter. 6 959-71 15821993 2004 Dec Plant molecular biology Cheng Ning-Hui|Hirschi Kendal D|Marshall Joy L|Morris Jay L|Pittman Jon K|Shigaki Toshiro

  18. Sensing of polymeric sensor-based rhodamine B derivative for metal ...

    Indian Academy of Sciences (India)

    TONG-MOU GENG1 XIE WANG1 FENG ZHU1 HUI JIANG1 YU WANG2. Collaborative Innovation Center for Petrochemical New Materials, Anhui Key Laboratory of Functional Coordination Compounds, School of Chemistry and Chemical Engineering, Anqing Normal University, Anqing 246011, People's Republic of China ...

  19. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Yan-Ze Peng1 E V Krishnan2 Hui Feng1. School of Mathematics and Statistics, Wuhan University, Wuhan 430072, People's Republic of China; Department of Mathematics and Statistics, Sultan Qaboos University, P.O. Box 36, Al-Khod 123, Muscat, Sultanate of Oman ...

  20. High-precision prostate cancer irradiation by clinical application of an offline patient setup verification procedure, using portal imaging

    NARCIS (Netherlands)

    Bel, A.; Vos, P. H.; Rodrigus, P. T.; Creutzberg, C. L.; Visser, A. G.; Stroom, J. C.; Lebesque, J. V.

    1996-01-01

    PURPOSE: To investigate in three institutions, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis [AvL]), Dr. Daniel den Hoed Cancer Center (DDHC), and Dr, Bernard Verbeeten Institute (BVI), how much the patient setup accuracy for irradiation of prostate cancer can be improved by an

  1. Energy diversification and renewable energies for the coming decade

    International Nuclear Information System (INIS)

    Plumejeaud, D.

    1999-01-01

    In the last issue of Gaz d'Aujourd'hui, the relation between energy and ethics during the next century was discussed. This article pursues this reflection, focusing on the problems raised by energy diversification through the use of renewable energies. It presents the main points raised during a meeting held on this topic. (author)

  2. Case note: EHRM (26692/05: C.A.S. en C.S. / Roemenië)

    NARCIS (Netherlands)

    de Graaf, J.H.

    2012-01-01

    In deze zaak staat de vraag centraal naar de vermeende schending van art. 3 en art. 8 EVRM. Klagers in deze zaak, inwoners van Roemenië, zijn vader en zoon. De feiten in deze zaak zijn als volgt. In januari 1998 wordt de zoon - dan zeven jaar oud - op weg van school naar huis gevolgd door een man,

  3. Recherche jusqu'ou ira le

    CERN Multimedia

    Jacob, F R

    2003-01-01

    Aujourd'hui, la puissance d'une nation s'evalue a son potentiel scientifique. C'est leur predominance en sciences qui a donne aux Etats-Unis leur superiorite dans de nombreux domaines: industriel, agricole, militaire, etc. Cette superiorite a debute a la fin de la seconde guerre mondiale" (2 pages).

  4. Association between vitamin D receptor gene polymorphism (TaqI)

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 94; Issue 3. Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. Hui-Ru Fan Li-Qun Lin Hao Ma Ying Li Chang-Hao Sun. Research Note Volume 94 Issue 3 September 2015 pp 473-478 ...

  5. Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle.

    Science.gov (United States)

    Martínez-Reyes, Inmaculada; Chandel, Navdeep S

    2017-12-05

    Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. High-precision prostate cancer irradiation by clinical application of an offline patient setup verification procedure, using portal imaging

    NARCIS (Netherlands)

    A. Bel (Arjan); P.H. Vos (Pieter); P. Rodrigus (Patrick); C.L. Creutzberg (Carien); A.G. Visser (Andries); J.Ch. Stroom (Joep); J.V. Lebesque (Joos)

    1996-01-01

    textabstractPurpose: To investigate in three institutions, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis [AvL]), Dr. Daniel den Hoed Cancer Center (DDHC), and Dr. Bernard Verbeeten Institute (BVI), how much the patient setup accuracy for irradiation of prostate cancer can be improved

  7. José Antonio Ocampo : l'inclusion sociale et économique est ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    14 oct. 2015 ... ... haut niveau aux Nations Unies et au sein du gouvernement colombien, notamment celui de ministre de l'Agriculture et du Développement rural, est aujourd'hui directeur du programme de développement économique et politique de la School of International and Public Affairs de la Columbia University.

  8. Collagen I-induced dendritic cells activation is regulated by TNF-α ...

    Indian Academy of Sciences (India)

    Barun Poudel1 2 Hyeon-Hui Ki1 Young-Mi Lee2 Dae-Ki Kim1. Department of Immunology and Institute of Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756, Korea; Department of Oriental Pharmacy, College of Pharmacy, Wonkwang Korean Medicines Research Institute, Wonkwang ...

  9. [Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2010-01-01

    Arvustus: Gao Jingyi. Han yu yu bei Ou yu yan : Han yu yu Wula'er yu yan ji Yin Ou yu yan tong yuan tan jiu = Chinese language and languages of northern Europe. Beijing : Zhongguo she hui ke xue chu ban she, 2008

  10. Targeting Breast Cancer Stem Cells in Triple-Negative Breast Cancer

    Science.gov (United States)

    2015-10-01

    atrophic endometrium in Brazil. Sao Paulo Med J 2011;129:320–4. 79. Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M, Hui CC, Clevers H...defining the molecular basis for resistance. Oncol Rep 2011;25:855–62. 138. Verdi J, Tan A, Shoae-Hassani A, Seifalian AM. Endometrial stem cells in

  11. Verification of the utility of molecular markers linked to the multiple ...

    African Journals Online (AJOL)

    GREGORY

    2010-08-30

    Aug 30, 2010 ... Feng Hui*, Wang Lili, Wei Peng, Liu Zhiyong, Li Chengyu, Wang Yugang, Ji Ruiqin and Zhang. Huaqing ..... Chin. Agric. Sci. Bull. 22: 377-379. Li CY, Feng H, Wei P, Wang LL, Zhang J, Yang HN, Jiang N (2009). Directional transfer of the genic multiple allele inherited male sterile line in Chinese cabbage.

  12. Overexpression of CFH gene in pterygiumv patients | Bang | Tropical ...

    African Journals Online (AJOL)

    Overexpression of CFH gene in pterygiumv patients. Man-Seok Bang, Chang Rae Rho, Bong-Hui Kang, Kyong Jin Cho, Chung-Hun Oh. Abstract. Purpose: To investigate the expression of complement factors in pterygium tissues compared to normal conjunctival samples, using next-generation RNA sequencing. Methods: ...

  13. WAN-MING LIU

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. WAN-MING LIU. Articles written in Sadhana. Volume 41 Issue 7 July 2016 pp 713-719. Integrated fleet assignment and aircraft routing based on delay propagation · WAN-MING LIU XING-HUI ZHU YAN-LONG QI · More Details Abstract Fulltext PDF. Airlines' expensive resources, especially aircraft ...

  14. Production and refining of Dacryodes edulis “native pear” seeds oil

    African Journals Online (AJOL)

    STORAGESEVER

    2008-05-02

    May 2, 2008 ... ml/g). Bleaching of 0.2% Na2CO3 degummed oil resulted in oil with peroxide value of 20 mgEq/Kg which ... Nigeria, Liberia, Cameroons and Zaire (Boungou, et al., .... Hui YJ Ed., John Wiley and Sons ... Robert Maxwell, pp.

  15. Les origines de l'alchimie

    CERN Document Server

    Berthelot, Marcellin

    2015-01-01

    Extrait :""Le monde est aujourd'hui sans mystère : la conception rationnelle prétend tout éclairer et tout comprendre ; elle s'efforce de donner de toute chose une explication positive et logique, et elle étend son déterminisme jusqu'au monde moral...""

  16. Résultats de recherche | Page 427 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Fatal Indifference : The G8, Africa, and Global Health. Le G8 (Allemagne, Angleterre, Canada, États-Unis, France, Italie, Japon, Russie et Union européenne) est aujourd'hui le principal vecteur politique de la mondialisation. Publication Date. 31 août 2004. Livres.

  17. Health | Page 23 | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le G8 (Allemagne, Angleterre, Canada, États-Unis, France, Italie, Japon, Russie et Union européenne) est aujourd'hui le principal vecteur politique de la mondialisation. Il est également la force politique qui soutient le plus fermement les institutions multilatérales façonnant la gouvernance économique mondiale.

  18. Les oligonucléotides synthétiques "antisens" (1re partie)

    OpenAIRE

    Cravador, A.

    1994-01-01

    Le sujet que nous abordons aujourd'hui est une illustration de l'évolution des approches chimiques qui visent à obtenir des molécules ayant des effets biologiques (par exemple dans la recherche de nouveaux médicaments), ou qui fonctionnent comme sonde (par exemple dans le diagnostic médical).

  19. Autonomy Level Specification for Intelligent Autonomous Vehicles

    Science.gov (United States)

    2003-09-01

    Autonomy Level Specification for Intelligent Autonomous Vehicles : Interim Progress Report Hui-Min Huang, Elena Messina, James Albus...Level Specification for Intelligent Autonomous Vehicles : Interim Progress Report 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  20. Résultats de recherche | Page 17 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    privé. Les régimes du monde entier ont connu des bouleversements négatifs au cours des dernières décennies : aujourd'hui, on compte près de deux milliards de personnes obèses ou présentant un surpoids, et les maladies non ...

  1. 182 L'erotisme Dans Uwaoma Et Le Beau Monde D'ifeoma ...

    African Journals Online (AJOL)

    Tracie1

    érotisme: Essai de définition. Il importe de mettre en ..... de son temps. Dans le monde d'aujourd'hui à la radio, à la télévision, dans les quotidiens, sur internet, dans les media sociaux tels que le facebook, le you-tube, le blackberry messenger ...

  2. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Synthesis and bio-catalytic activity of isostructural cobalt(III)-phenanthroline complexes · Dhananjay Dey Arnab Basu Roy Anandan Ranjani Loganathan Gayathri Saravanan Chandraleka Dharumadurai Dhanasekaran Mohammad Abdulkader Akbarsha Chung-Yu Shen Hui-Lien Tsai Milan Maji Niranjan Kole Bhaskar ...

  3. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 2037 ... Vol 14, No 11 (2015), Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii, Abstract PDF. Ling Zhang, Shu-gen Xu, Wei Liang, Jun Mei, Yue-ying Di, Hui-hua Lan, Yan Yang, Wei-wei Wang, Yuan-yuan Luo, Hou-zhao Wang.

  4. Tropical Journal of Pharmaceutical Research - Vol 14, No 11 (2015)

    African Journals Online (AJOL)

    Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Ling Zhang, Shu-gen Xu, Wei Liang, Jun Mei, Yue-ying Di, Hui-hua Lan, Yan Yang, ...

  5. Health-related quality of life before and after management in adults referred to otolaryngology: rospective national study

    Science.gov (United States)

    Swan, IRC; Guy, FH; Akeroyd, MA

    2012-01-01

    Objective An assessment of the effect of otolaryngological management on the health-related quality of life of patients. Design Application of the Health Utilities Index mark 3 (HUI-3) before and after treatment; application of the Glasgow Benefit Inventory (GBI) after treatment. Setting Six otolaryngological departments around Scotland. Participants A 9005 adult patients referred to outpatient clinics. Main outcome measures Complete HUI-3 data was collected from 4422 patients; complete GBI data from 4235; complete HUI-3 and GBI data from 3884. Results The overall change in health related quality of life from before to after management was just +0.02. In the majority of subgroups of data (classified by type of management) there was essentially no change in HUI-3 score. The major exceptions were those patients provided with a hearing aid (mean change 0.08) and those whose problem was managed surgically (mean change 0.04). The mean GBI score was 5.3 which is low. Those managed surgically reported a higher GBI score of 13.0. Conclusion We found that patients treated surgically or given a hearing aid reported a significant improvement in their health related quality of life after treatment in otolaryngology departments. In general, patients treated in other ways reported no significant improvement. We argue that future research should look carefully at patient groups where there is unexpectedly little benefit from current treatment methods and consider more effective methods of management. PMID:22212609

  6. African Journal of Traditional, Complementary and Alternative ...

    African Journals Online (AJOL)

    Diuretic and anti-diuretic bioactivity differences of the seed and shell extracts of Alpinia oxyphylla fruit · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Yong-hui Li, Yin-feng Tan, Na Wei, Jun-qing Zhang, 25-32 ...

  7. High-temperature thermoelectric properties of AgxYyCa2⋅ 8Co4O9 ...

    Indian Academy of Sciences (India)

    temperature thermoelectric properties of AgYCa2.8Co4O9 + ceramics. Youjin Zheng Hui Zhou Tengzhou Ma Guihong Zuo Hongtao Li Taichao Su Chunlei Wu Hailiang Huang Dan Wang Longcheng Yin. Volume 37 Issue 5 August 2014 pp 963- ...

  8. Een (Duits) eitje : afzet biologische pluimveehouderij 2005

    NARCIS (Netherlands)

    Werf, van der J.T.N.; Kijlstra, A.

    2005-01-01

    Het aantal biologische pluimveebedrijven in Nederland neemt snel toe. Veel van de grotere biologische bedrijven exporteren hun eieren via pakstations naar Duitsland. De rest van de bedrijven zet de eieren binnenlands af via pakstations en een deel verkoopt ze direct aan huis of via

  9. Het Fries als voorbeeldige taal - in alle stadia

    NARCIS (Netherlands)

    Versloot, A.P.

    2008-01-01

    ‘In ons Morfo-project proberen we de structuur van de Friese woordenschat bloot te leggen. We verbinden taalelementen die van dezelfde stam zijn afgeleid met elkaar: binnen én tussen de taalstadia. Een voorbeeld is het woord hûs, "huis". Dat zit in het woord útfanhûzje, "logeren", net zo goed als in

  10. Characters analysis of the Macadamia cv. Ikaika (333) germplasm ...

    African Journals Online (AJOL)

    ajl yemi

    2011-11-30

    Nov 30, 2011 ... germplasm resource. Liqing Du, Hui Zeng*, ... needed by human body, but is rich in mineral and vitamin as well. .... It was suggested that climate and orchard management are the main .... than that in South Africa at their 5th, 6th and 7th year respectively, but .... In Chan HT (Ed.), Handbook of tropical foods .

  11. Modeling Wind Wave Evolution from Deep to Shallow Water

    Science.gov (United States)

    2014-09-30

    W.H. Hui, 1979; Nonlinear energy transfer in narrow gravity wave spectrum. Proc. Roy. Soc. London A368, 239–265. Gagnaire-Renou, E., M. Benoit , and P...at the 2013 WISE meeting, Camp Springs, MA , USA. Smit P. B. and T. T. Janssen, 2013; The evolution of inhomogeneous wave statistics through a

  12. Is Best-Worst Scaling Suitable for Health State Valuation? A Comparison with Discrete Choice Experiments.

    Science.gov (United States)

    Krucien, Nicolas; Watson, Verity; Ryan, Mandy

    2017-12-01

    Health utility indices (HUIs) are widely used in economic evaluation. The best-worst scaling (BWS) method is being used to value dimensions of HUIs. However, little is known about the properties of this method. This paper investigates the validity of the BWS method to develop HUI, comparing it to another ordinal valuation method, the discrete choice experiment (DCE). Using a parametric approach, we find a low level of concordance between the two methods, with evidence of preference reversals. BWS responses are subject to decision biases, with significant effects on individuals' preferences. Non parametric tests indicate that BWS data has lower stability, monotonicity and continuity compared to DCE data, suggesting that the BWS provides lower quality data. As a consequence, for both theoretical and technical reasons, practitioners should be cautious both about using the BWS method to measure health-related preferences, and using HUI based on BWS data. Given existing evidence, it seems that the DCE method is a better method, at least because its limitations (and measurement properties) have been extensively researched. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  13. Draft Genome Sequence of Streptococcus agalactiae Serotype Ia Strain M19, a Multidrug-Resistant Isolate from a Cow with Bovine Mastitis

    OpenAIRE

    Yang, Feng; Li, Hongsheng; Zhang, Shidong; Wang, Xurong

    2016-01-01

    Streptococcus agalactiae is a major contagious pathogen causing bovine mastitis worldwide. We report here the draft sequence of S.?agalactiae Ia strain M19, a multidrug-resistant isolate from a bovine mastitis case in Ningxia Hui autonomous region, China.

  14. AGARD/SMP Review Damage Tolerance for Engine Structures. 3. Component Behaviour and Life Management

    Science.gov (United States)

    1990-06-01

    logistic and financial planning of engine overhauls and component replacements. Conclusions This workshop covers the critical technologies that relate the...veloppements trZs importants do la part des instituits et laboratoires do recherchos 2A-2 franqais, soutenus en celii par la SNECD1A. Aujourd’hui, ces mod&1es

  15. At Home in a Digital World

    NARCIS (Netherlands)

    Jos de Haan; Frank Huysmans; Jan Steyaert

    2002-01-01

    Original title: Van huis uit digitaal. Young people grow up surrounded by digital media. Particularly at home, but increasingly at school as well, they have access to computers, the Internet and digital technology as well as information carriers such as video games and CD-ROMs. Some young

  16. Veranderde levenslopen : Trends in relatie- en gezinsvorming, 1900-1970

    NARCIS (Netherlands)

    A.C. Liefbroer (Aart); P.A. Dykstra (Pearl)

    2001-01-01

    textabstractDe levensloop van de man of vrouw die in 1900 is geboren ziet er heel anders uit dan van iemand die geboren is in 1970. De laatste gaat eerder uit huis, trouwt later en veelal pas na een paar jaar samenwonen. Paren stellen het krijgen van kinderen uit en gaan ook gemakkelijker uit

  17. Effects of 90-day feeding of transgenic Bt rice TT51 on the reproductive system in male rats.

    Science.gov (United States)

    Wang, Er Hui; Yu, Zhou; Hu, Jing; Xu, Hai Bin

    2013-12-01

    Rice is a staple food crop; however, the threat of pests leads to a serious decline in its output and quality. The CryAb/CryAc gene, encodes a synthetic fusion Bacillus thuringiensis (Bt) crystal protein, was introduced into rice MingHui63 to produce insect-resistant rice TT51. This study was undertaken to investigate potential unintended effects of TT51 on the reproductive system in male rats. Male rats were treated with diets containing 60% of either TT51 or MingHui63 by weight, nutritionally balanced to an AIN93G diet, for 90days. An additional negative control group of rats were fed with a rice-based AIN93G diet. Body weights, food intake, hematology, serum chemistry, serum hormone levels, sperm parameters and relative organ/body weights were measured, and gross as well as microscopic pathology were examined. No diet-related significant differences in the values of response variables were observed between rats that were fed with diet containing transgenic TT51, MingHui63 and the control in this 90-day feeding study. In addition, necropsy and histopathology examination indicated no treatment-related changes. The results from the present study indicated that TT51 does not appear to exert any effect on the reproductive system in male rats compared with MingHui63 or the control. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. DNA damage and decrease of cellular oxidase activity in piglet ...

    African Journals Online (AJOL)

    DNA damage and decrease of cellular oxidase activity in piglet sertoli cells exposed to gossypol. Ming Zhang, Hui Yuan, Zuping He, Liyun Yuan, Jine Yi, Sijun Deng, Li Zhu, Chengzhi Guo, Yin Lu, Jing Wu, Lixin Wen, Qiang Wei, Liqun Xue ...

  19. 76 FR 46898 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2011-08-03

    ... SOCORRO-VALLEJO ANGELA MARIE DELEEDE ANTHONY G DESAI ANAND R DESPERT ALAIN FERNAND DIEMER INGRID H DINGER... VELLOSO FREIRE HENTSCH FLAVIA VELLOSO FREIRE HERRERA GUSTAVO A HERZ STEPHEN OLIVER HEURTEMATTE ELIZABETH... HOYES STEPHEN HSU CHIN CHI HSU MING YU HSU TSUI CHING HUANG KUO-WEI HUI KAM KWEI HUTCHINSON MARY JEANNE...

  20. Résultats de recherche | Page 440 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Democracy, Citizenship and Youth : Towards Social and Political Participation in Brazil. Quelle est la place des jeunes dans le monde complexe et en constante mutation d'aujourd'hui ... Digital Review of Asia Pacific 2009–2010. Publié tous les deux ans, cet ouvrage se veut un guide exhaustif de l'état de la pratique et des ...

  1. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. CHU-ZHAO LEI. Articles written in Journal of Genetics. Volume 89 Issue 2 August 2010 pp 233-236 Research Note. Two novel single nucleotide polymorphisms (SNPs) and 4-bp deletion mutation of RBP4 gene in Chinese cattle · Mou Wang Xinsheng Lai Hui Yu Juqiang Wang ...

  2. Santé | Page 2 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Obesity is a risk factor for many NCDs, including stroke, heart disease, hypertension, diabetes, and cancer. Read more about Addressing obesity in South Africa through taxation. Langue English. La Terre compte aujourd'hui le plus grand nombre de jeunes (entre 10 et 24 ans) de tous les temps. Malheureusement, la réalité ...

  3. State-of-the-art technologies of forest inventory and monitoring in Taiwan

    Science.gov (United States)

    Fong-Long Feng

    2000-01-01

    Ground surveys, remote sensing (RS), global positioning systems (GPS), geographic information systems (GIS), and permanent sampling plots (PSP) were used to inventory and monitor forests in the development of an ecosystem management plan for the island of Taiwan. While the entire island has been surveyed, this study concentrates on the Hui-Sun and Hsin-Hua Experimental...

  4. Huisverkoop van biologisch vlees : handboek

    NARCIS (Netherlands)

    Heijden, van der C.H.T.M.

    2005-01-01

    Voor biologische boeren die willen beginnen met de verkoop van biologisch vlees aan huis, is het 'Handboek Huisverkoop Biologisch Vlees' samengesteld. Het handboek bevat o.a. marketingtips en een overzicht van de wet- en regelgeving. Het is opgesteld door Wageningen UR in samenwerking met Biologica

  5. ABSCISIC ACID EFFECTS ON WATER AND PHOTOSYNTHETIC ...

    African Journals Online (AJOL)

    Bidai Y, Achour A and Belkhodja M

    1 mai 2016 ... Keywords: Phytohormone; drought; xerophyte; water status; ... induisent la synthèse de l'ABA, considéré aujourd'hui comme une hormone de stress [9, .... à α <0.05) et enfin de l'interaction " ABA x écotype x Durée" (F= 46,50 ...

  6. : tous les projets | Page 27 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les chaînes de valeur mondiales, qui constituent aujourd'hui la plus importante part du commerce mondial, se composent de producteurs et d'entreprises qui créent des biens comme entrants destinés à d'autres producteurs. Région: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, ...

  7. : tous les projets | Page 26 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les chaînes de valeur mondiales, qui constituent aujourd'hui la plus importante part du commerce mondial, se composent de producteurs et d'entreprises qui créent des biens comme entrants destinés à d'autres producteurs. Région: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, ...

  8. Vieillissement de la population : trouver un équilibre | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 mars 2012 ... Prenons pour exemple les Philippines. La population de ce pays est encore relativement jeune, mais elle commence à vieillir. Les personnes âgées représentent aujourd'hui 5 % de la population, mais cette proportion sera de 12 % d'ici 2040. Le gouvernement devra offrir un meilleur soutien à un nombre ...

  9. Laos : tous les projets | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les chaînes de valeur mondiales, qui constituent aujourd'hui la plus importante part du commerce mondial, se composent de producteurs et d'entreprises qui créent des biens comme entrants destinés à d'autres producteurs. Région: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, South Asia, Far East Asia, ...

  10. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. Ju Wei. Articles written in Journal of Earth System Science. Volume 125 Issue 5 July 2016 pp 1021-1031. Tectonic stress accumulation in Bohai–Zhangjiakou Seismotectonic Zone based on 3D visco-elastic modelling · Ju Wei Sun Weifeng Ma Xiaojing Jiang Hui.

  11. Mining microsatellite markers from public expressed sequence tag

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 91; Issue 3. Mining microsatellite markers from public expressed sequence tag sequences for genetic diversity analysis in pomegranate. Zai-Hai Jian Xin-She Liu Jian-Bin Hu Yan-Hui Chen Jian-Can Feng. Research Note Volume 91 Issue 3 December 2012 pp 353-358 ...

  12. Sublinear Space Algorithms for the Longest Common Substring Problem

    DEFF Research Database (Denmark)

    Kociumaka, Tomasz; Starikovskaya, Tatiana; Vildhøj, Hjalte Wedel

    2014-01-01

    Given m documents of total length n, we consider the problem of finding a longest string common to at least d ≥ 2 of the documents. This problem is known as the longest common substring (LCS) problem and has a classic O(n) space and O(n) time solution (Weiner [FOCS'73], Hui [CPM'92]). However...

  13. Topics in combinatorial pattern matching

    DEFF Research Database (Denmark)

    Vildhøj, Hjalte Wedel

    Problem. Given m documents of total length n, we consider the problem of finding a longest string common to at least d ≥ 2 of the documents. This problem is known as the longest common substring (LCS) problem and has a classic O(n) space and O(n) time solution (Weiner [FOCS’73], Hui [CPM’92]). However...

  14. Résultats de recherche | Page 428 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    humanité est de plus en plus tributaire des ressources marines et côtières. Les petites entreprises de pêche emploient aujourd'hui 50 des 51 millions de pêcheurs du monde, qui se trouvent pratiquement tous dans des pays en développement.

  15. Toe Elvis ophou sing. Juanita Aggenbach. Pretoria: Protea Boekhuis ...

    African Journals Online (AJOL)

    die Melanie oor wie se lewe dit hier gaan, grootword en die huis verlaat waar haar pa in sy besopenheid die meubels en haar ma verniel, is die perspektief op byvoorbeeld seks romanties versluierd en al die emo- sionele reaksies ondanks die grimmigheid daarvan gerusstellend eerder as skokkend openbarend.

  16. Sex differences in the relative contribution of social and clinical factors to the Health Utilities Index Mark 2 measure of health-related quality of life in older home care clients

    Directory of Open Access Journals (Sweden)

    Hogan David B

    2009-09-01

    Full Text Available Abstract Background The heterogeneity evident among home care clients highlights the need for greater understanding of the clinical and social determinants of multi-dimensional health-related quality of life (HRQL indices and of potential sex-differences in these determinants. We examined the relative contribution of social and clinical factors to HRQL among older home care clients and explored whether any of the observed associations varied by sex. Methods The Canadian-US sample included 514 clients. Self-reported HRQL was measured during in-home interviews (2002-04 using the Health Utilities Index Mark 2 (HUI2. Data on clients' sociodemographic, health and clinical characteristics were obtained with the Minimum Data Set for Home Care. The relative associations between clients' characteristics and HUI2 scores were examined using multivariable linear regression models. Results Women had a significantly lower mean HUI2 score than men (0.48, 95%CI 0.46-0.50 vs. 0.52, 0.49-0.55. Clients with distressed caregivers and poor self-rated health exhibited significantly lower HRQL scores after adjustment for a comprehensive list of clinical conditions. Several other factors remained statistically significant (arthritis, psychiatric illness, bladder incontinence, urinary tract infection or clinically important (reported loneliness, congestive heart failure, pressure ulcers correlates of lower HUI2 scores in adjusted analyses. These associations generally did not vary significantly by sex. Conclusion For females and males, HRQL scores were negatively associated with conditions predictive or indicative of disability and with markers of psychosocial stress. Despite sex differences in the prevalence of social and clinical factors likely to affect HRQL, few varied significantly by sex in their relative impact on HUI2 scores. Further exploration of differences in the relative importance of clinical and psychosocial well-being (e.g., loneliness to HRQL among

  17. Parental Perceptions of Quality of Life in Children on Long-Term Ventilation at Home as Compared to Enterostomy Tubes.

    Directory of Open Access Journals (Sweden)

    Brahim Redouane

    Full Text Available Health related quality of life (HRQL of children using medical technology at home is largely unknown. Our aim was to examine the HRQL in children on long-term ventilation at home (LTHV in comparison to a cohort using an enterostomy tube.Participants were divided into three groups: 1 LTHV without an enterostomy tube (LTHV cohort; 2 Enterostomy tube (GT cohort; 3 LTHV with an enterostomy tube (LTHV+GT cohort. Caregivers of children ≥ 5 years and followed at SickKids, Toronto, Canada, completed three questionnaires: Health Utilities Index 2/3 (HUI2/3, Caregiver Priorities Caregiver Health Index (CPCHILD, and the Paediatric Quality of Life Inventory (PedsQL. The primary outcome was the difference in utility (HUI2/3 scores between the cohorts.One hundred and nineteen children were enrolled; 47 in the LTHV cohort, 44 in the GT cohort, and 28 in the LTHV+GT cohort. In univariate analysis, HUI2 mean (SE scores were lowest for the GT cohort, 0.4 (0.04 followed by the LTHV+GT, 0.42 (0.05 and then the LTHV cohort, 0.7 (0.04, p = 0.001. A similar trend was seen for the HUI3 mean (SE scores: GT cohort, 0.1 (0.06, followed by the LTHV +GT cohort, 0.2 (0.08 and then the LTHV cohort, 0.5 (0.06, p = 0.0001. Technology cohort, nursing hours and the severity of health care needs predicted HRQL as measured by the HUI2/3.The HRQL of these children is low. Children on LTHV had higher HRQL than children using enterostomy tubes. Further work is needed to identify modifiable factors that can improve HRQL.

  18. Preventing Depression in Adults With Subthreshold Depression: Health-Economic Evaluation Alongside a Pragmatic Randomized Controlled Trial of a Web-Based Intervention.

    Science.gov (United States)

    Buntrock, Claudia; Berking, Matthias; Smit, Filip; Lehr, Dirk; Nobis, Stephanie; Riper, Heleen; Cuijpers, Pim; Ebert, David

    2017-01-04

    Psychological interventions for the prevention of depression might be a cost-effective way to reduce the burden associated with depressive disorders. To evaluate the cost-effectiveness of a Web-based guided self-help intervention to prevent major depressive disorder (MDD) in people with subthreshold depression (sD). A pragmatic randomized controlled trial was conducted with follow-up at 12 months. Participants were recruited from the general population via a large statutory health insurance company and an open access website. Participants were randomized to a Web-based guided self-help intervention (ie, cognitive-behavioral therapy and problem-solving therapy assisted by supervised graduate students or health care professionals) in addition to usual care or to usual care supplemented with Web-based psycho-education (enhanced usual care). Depression-free years (DFYs) were assessed by blinded diagnostic raters using the telephone-administered Structured Clinical Interview for DSM-IV Axis Disorders at 6- and 12-month follow-up, covering the period to the previous assessment. Costs were self-assessed through a questionnaire. Costs measured from a societal and health care perspective were related to DFYs and quality-adjusted life years (QALYs). In total, 406 participants were enrolled in the trial. The mean treatment duration was 5.84 (SD 4.37) weeks. On average, participants completed 4.93 of 6 sessions. Significantly more DFYs were gained in the intervention group (0.82 vs 0.70). Likewise, QALY health gains were in favor of the intervention, but only statistically significant when measured with the more sensitive SF-6D. The incremental per-participant costs were €136 (£116). Taking the health care perspective and assuming a willingness-to-pay of €20,000 (£17,000), the intervention's likelihood of being cost-effective was 99% for gaining a DFY and 64% or 99% for gaining an EQ-5D or a SF-6D QALY. Our study supports guidelines recommending Web-based treatment for s

  19. The Effect of a Patient-Provider Educational Intervention to Reduce At-Risk Drinking on Changes in Health and Health-Related Quality of Life Among Older Adults: The Project SHARE Study.

    Science.gov (United States)

    Barnes, Andrew J; Xu, Haiyong; Tseng, Chi-Hong; Ang, Alfonso; Tallen, Louise; Moore, Alison A; Marshall, Deborah C; Mirkin, Michelle; Ransohoff, Kurt; Duru, O Kenrik; Ettner, Susan L

    2016-01-01

    At-risk drinking, defined as alcohol use that is excessive or potentially harmful in combination with select comorbidities or medications, affects about 10% of older adults in the United States and is associated with higher mortality. The Project SHARE intervention, which uses patient and provider educational materials, physician counseling, and health educator support, was designed to reduce at-risk drinking among this vulnerable population. Although an earlier study showed that this intervention was successful in reducing rates of at-risk drinking, it is unknown whether these reductions translate into improved health and health-related quality of life (HRQL). The aim of this study was to examine changes in health and HRQL of older adult at-risk drinkers resulting from a patient-provider educational intervention. A randomized controlled trial to compare the health and HRQL outcomes of patients assigned to the Project SHARE intervention vs. care as usual at baseline, 6- and 12-months post assignment. Control patients received usual care, which may or may not have included alcohol counseling. Intervention group patients received a personalized patient report, educational materials on alcohol and aging, a brief provider intervention, and a telephone health educator intervention. Current drinkers 60years and older accessing primary care clinics around Santa Barbara, California (N=1049). Data were collected from patients using baseline, 6- and 12-month mail surveys. Health and HRQL measures included mental and physical component scores (MCS and PCS) based on the Short Form-12v2 (SF-12v2), the SF-6D, which is also based on the SF-12, and the Geriatric Depression Scale (GDS). Adjusted associations of treatment assignment with these outcomes were estimated using generalized least squares regressions with random provider effects. Regressions controlled for age group, sex, race/ethnicity, marital status, education, household income, home ownership and the baseline value of

  20. Search for single production of vector-like quarks decaying into $Wb$ in $pp$ collisions at $\\sqrt{s} =$ 8 TeV with the ATLAS detector

    CERN Document Server

    Aad, Georges; Abdallah, Jalal; Abdinov, Ovsat; Abeloos, Baptiste; Aben, Rosemarie; Abolins, Maris; AbouZeid, Ossama; Abramowicz, Halina; Abreu, Henso; Abreu, Ricardo; Abulaiti, Yiming; Acharya, Bobby Samir; Adamczyk, Leszek; Adams, David; Adelman, Jahred; Adomeit, Stefanie; Adye, Tim; Affolder, Tony; Agatonovic-Jovin, Tatjana; Agricola, Johannes; Aguilar-Saavedra, Juan Antonio; Ahlen, Steven; Ahmadov, Faig; Aielli, Giulio; Akerstedt, Henrik; Åkesson, Torsten Paul Ake; Akimov, Andrei; Alberghi, Gian Luigi; Albert, Justin; Albrand, Solveig; Alconada Verzini, Maria Josefina; Aleksa, Martin; Aleksandrov, Igor; Alexa, Calin; Alexander, Gideon; Alexopoulos, Theodoros; Alhroob, Muhammad; Alimonti, Gianluca; Alio, Lion; Alison, John; Alkire, Steven Patrick; Allbrooke, Benedict; Allen, Benjamin William; Allport, Phillip; Aloisio, Alberto; Alonso, Alejandro; Alonso, Francisco; Alpigiani, Cristiano; Alvarez Gonzalez, Barbara; Άlvarez Piqueras, Damián; Alviggi, Mariagrazia; Amadio, Brian Thomas; 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Cúth, Jakub; Cuthbert, Cameron; Czirr, Hendrik; Czodrowski, Patrick; D'Auria, Saverio; D'Onofrio, Monica; Da Cunha Sargedas De Sousa, Mario Jose; Da Via, Cinzia; Dabrowski, Wladyslaw; Dafinca, Alexandru; Dai, Tiesheng; Dale, Orjan; Dallaire, Frederick; Dallapiccola, Carlo; Dam, Mogens; Dandoy, Jeffrey Rogers; Dang, Nguyen Phuong; Daniells, Andrew Christopher; Danninger, Matthias; Dano Hoffmann, Maria; Dao, Valerio; Darbo, Giovanni; Darmora, Smita; Dassoulas, James; Dattagupta, Aparajita; Davey, Will; David, Claire; Davidek, Tomas; Davies, Eleanor; Davies, Merlin; Davison, Peter; Davygora, Yuriy; Dawe, Edmund; Dawson, Ian; Daya-Ishmukhametova, Rozmin; De, Kaushik; de Asmundis, Riccardo; De Benedetti, Abraham; De Castro, Stefano; De Cecco, Sandro; De Groot, Nicolo; de Jong, Paul; De la Torre, Hector; De Lorenzi, Francesco; De Pedis, Daniele; De Salvo, Alessandro; De Sanctis, Umberto; De Santo, Antonella; De Vivie De Regie, Jean-Baptiste; Dearnaley, William James; Debbe, Ramiro; Debenedetti, Chiara; Dedovich, Dmitri; Deigaard, Ingrid; Del Peso, Jose; Del Prete, Tarcisio; Delgove, David; Deliot, Frederic; Delitzsch, Chris Malena; Deliyergiyev, Maksym; Dell'Acqua, Andrea; Dell'Asta, Lidia; Dell'Orso, Mauro; Della Pietra, Massimo; della Volpe, Domenico; Delmastro, Marco; Delsart, Pierre-Antoine; Deluca, Carolina; DeMarco, David; Demers, Sarah; Demichev, Mikhail; Demilly, Aurelien; Denisov, Sergey; Denysiuk, Denys; Derendarz, Dominik; Derkaoui, Jamal Eddine; Derue, Frederic; Dervan, Paul; Desch, Klaus Kurt; Deterre, Cecile; Dette, Karola; Deviveiros, Pier-Olivier; Dewhurst, Alastair; Dhaliwal, Saminder; Di Ciaccio, Anna; Di Ciaccio, Lucia; Di Domenico, Antonio; Di Donato, Camilla; Di Girolamo, Alessandro; Di Girolamo, Beniamino; Di Mattia, Alessandro; Di Micco, Biagio; Di Nardo, Roberto; Di Simone, Andrea; Di Sipio, Riccardo; Di Valentino, David; Diaconu, Cristinel; Diamond, Miriam; Dias, Flavia; Diaz, Marco Aurelio; Diehl, Edward; Dietrich, Janet; Diglio, Sara; Dimitrievska, Aleksandra; Dingfelder, Jochen; Dita, Petre; Dita, Sanda; Dittus, Fridolin; Djama, Fares; Djobava, Tamar; Djuvsland, Julia Isabell; Barros do Vale, Maria Aline; Dobos, Daniel; Dobre, Monica; Doglioni, Caterina; Dohmae, Takeshi; Dolejsi, Jiri; Dolezal, Zdenek; Dolgoshein, Boris; Donadelli, Marisilvia; Donati, Simone; Dondero, Paolo; Donini, Julien; Dopke, Jens; Doria, Alessandra; Dova, Maria-Teresa; Doyle, Tony; Drechsler, Eric; Dris, Manolis; Du, Yanyan; Duarte-Campderros, Jorge; Dubreuil, Emmanuelle; Duchovni, Ehud; Duckeck, Guenter; Ducu, Otilia Anamaria; Duda, Dominik; Dudarev, Alexey; Duflot, Laurent; Duguid, Liam; Dührssen, Michael; Dunford, Monica; Duran Yildiz, Hatice; Düren, Michael; Durglishvili, Archil; Duschinger, Dirk; Dutta, Baishali; Dyndal, Mateusz; Eckardt, Christoph; Ecker, Katharina Maria; Edgar, Ryan Christopher; Edson, William; Edwards, Nicholas Charles; Eifert, Till; Eigen, Gerald; Einsweiler, Kevin; Ekelof, Tord; El Kacimi, Mohamed; Ellajosyula, Venugopal; Ellert, Mattias; Elles, Sabine; Ellinghaus, Frank; Elliot, Alison; Ellis, Nicolas; Elmsheuser, Johannes; Elsing, Markus; Emeliyanov, Dmitry; Enari, Yuji; Endner, Oliver Chris; Endo, Masaki; Ennis, Joseph Stanford; Erdmann, Johannes; Ereditato, Antonio; Ernis, Gunar; Ernst, Jesse; Ernst, Michael; Errede, Steven; Ertel, Eugen; Escalier, Marc; Esch, Hendrik; Escobar, Carlos; Esposito, Bellisario; Etienvre, Anne-Isabelle; Etzion, Erez; Evans, Hal; Ezhilov, Alexey; Fabbri, Laura; Facini, Gabriel; Fakhrutdinov, Rinat; Falciano, Speranza; Falla, Rebecca Jane; Faltova, Jana; Fang, Yaquan; Fanti, Marcello; Farbin, Amir; Farilla, Addolorata; Farina, Christian; Farooque, Trisha; Farrell, Steven; Farrington, Sinead; Farthouat, Philippe; Fassi, Farida; Fassnacht, Patrick; Fassouliotis, Dimitrios; Faucci Giannelli, Michele; Favareto, Andrea; Fayard, Louis; Fedin, Oleg; Fedorko, Wojciech; Feigl, Simon; Feligioni, Lorenzo; Feng, Cunfeng; Feng, Eric; Feng, Haolu; Fenyuk, Alexander; Feremenga, Last; Fernandez Martinez, Patricia; Fernandez Perez, Sonia; Ferrando, James; Ferrari, Arnaud; Ferrari, Pamela; Ferrari, Roberto; Ferreira de Lima, Danilo Enoque; Ferrer, Antonio; Ferrere, Didier; Ferretti, Claudio; Ferretto Parodi, Andrea; Fiedler, Frank; Filipčič, Andrej; Filipuzzi, Marco; Filthaut, Frank; Fincke-Keeler, Margret; Finelli, Kevin Daniel; Fiolhais, Miguel; Fiorini, Luca; Firan, Ana; Fischer, Adam; Fischer, Cora; Fischer, Julia; Fisher, Wade Cameron; Flaschel, Nils; Fleck, Ivor; Fleischmann, Philipp; Fletcher, Gareth Thomas; Fletcher, Gregory; Fletcher, Rob Roy MacGregor; Flick, Tobias; Floderus, Anders; Flores Castillo, Luis; Flowerdew, Michael; Forcolin, Giulio Tiziano; Formica, Andrea; Forti, Alessandra; Fournier, Daniel; Fox, Harald; Fracchia, Silvia; Francavilla, Paolo; Franchini, Matteo; Francis, David; Franconi, Laura; Franklin, Melissa; Frate, Meghan; Fraternali, Marco; Freeborn, David; Fressard-Batraneanu, Silvia; Friedrich, Felix; Froidevaux, Daniel; Frost, James; Fukunaga, Chikara; Fullana Torregrosa, Esteban; Fusayasu, Takahiro; Fuster, Juan; Gabaldon, Carolina; Gabizon, Ofir; Gabrielli, Alessandro; Gabrielli, Andrea; Gach, Grzegorz; Gadatsch, Stefan; Gadomski, Szymon; Gagliardi, Guido; Gagnon, Pauline; Galea, Cristina; Galhardo, Bruno; Gallas, Elizabeth; Gallop, Bruce; Gallus, Petr; Galster, Gorm Aske Gram Krohn; Gan, KK; Gao, Jun; Gao, Yanyan; Gao, Yongsheng; Garay Walls, Francisca; García, Carmen; García Navarro, José Enrique; Garcia-Sciveres, Maurice; Gardner, Robert; Garelli, Nicoletta; Garonne, Vincent; Gatti, Claudio; Gaudiello, Andrea; Gaudio, Gabriella; Gaur, Bakul; Gauthier, Lea; Gavrilenko, Igor; Gay, Colin; Gaycken, Goetz; Gazis, Evangelos; Gecse, Zoltan; Gee, Norman; Geich-Gimbel, Christoph; Geisler, Manuel Patrice; Gemme, Claudia; Genest, Marie-Hélène; Geng, Cong; Gentile, Simonetta; George, Simon; Gerbaudo, Davide; Gershon, Avi; Ghasemi, Sara; Ghazlane, Hamid; Giacobbe, Benedetto; Giagu, Stefano; Giannetti, Paola; Gibbard, Bruce; Gibson, Stephen; Gignac, Matthew; Gilchriese, Murdock; Gillam, Thomas; Gillberg, Dag; Gilles, Geoffrey; Gingrich, Douglas; Giokaris, Nikos; Giordani, MarioPaolo; Giorgi, Filippo Maria; Giorgi, Francesco Michelangelo; Giraud, Pierre-Francois; Giromini, Paolo; Giugni, Danilo; Giuliani, Claudia; Giulini, Maddalena; Gjelsten, Børge Kile; Gkaitatzis, Stamatios; Gkialas, Ioannis; Gkougkousis, Evangelos Leonidas; Gladilin, Leonid; Glasman, Claudia; Glatzer, Julian; Glaysher, Paul; Glazov, Alexandre; Goblirsch-Kolb, Maximilian; Goddard, Jack Robert; Godlewski, Jan; Goldfarb, Steven; Golling, Tobias; Golubkov, Dmitry; Gomes, Agostinho; Gonçalo, Ricardo; Goncalves Pinto Firmino Da Costa, Joao; Gonella, Laura; González de la Hoz, Santiago; Gonzalez Parra, Garoe; Gonzalez-Sevilla, Sergio; Goossens, Luc; Gorbounov, Petr Andreevich; Gordon, Howard; Gorelov, Igor; Gorini, Benedetto; Gorini, Edoardo; Gorišek, Andrej; Gornicki, Edward; Goshaw, Alfred; Gössling, Claus; Gostkin, Mikhail Ivanovitch; Goudet, Christophe Raymond; Goujdami, Driss; Goussiou, Anna; Govender, Nicolin; Gozani, Eitan; Graber, Lars; Grabowska-Bold, Iwona; Gradin, Per Olov Joakim; Grafström, Per; Gramling, Johanna; Gramstad, Eirik; Grancagnolo, Sergio; Gratchev, Vadim; Gray, Heather; Graziani, Enrico; Greenwood, Zeno Dixon; Grefe, Christian; Gregersen, Kristian; Gregor, Ingrid-Maria; Grenier, Philippe; Grevtsov, Kirill; Griffiths, Justin; Grillo, Alexander; Grimm, Kathryn; Grinstein, Sebastian; Gris, Philippe Luc Yves; Grivaz, Jean-Francois; Groh, Sabrina; Grohs, Johannes Philipp; Gross, Eilam; Grosse-Knetter, Joern; Grossi, Giulio Cornelio; Grout, Zara Jane; Guan, Liang; Guenther, Jaroslav; Guescini, Francesco; Guest, Daniel; Gueta, Orel; Guido, Elisa; Guillemin, Thibault; Guindon, Stefan; Gul, Umar; Gumpert, Christian; Guo, Jun; Guo, Yicheng; Gupta, Shaun; Gustavino, Giuliano; Gutierrez, Phillip; Gutierrez Ortiz, Nicolas Gilberto; Gutschow, Christian; Guyot, Claude; Gwenlan, Claire; Gwilliam, Carl; Haas, Andy; Haber, Carl; Hadavand, Haleh Khani; Haddad, Nacim; Hadef, Asma; Haefner, Petra; Hageböck, Stephan; Hajduk, Zbigniew; Hakobyan, Hrachya; Haleem, Mahsana; Haley, Joseph; Hall, David; Halladjian, Garabed; Hallewell, Gregory David; Hamacher, Klaus; Hamal, Petr; Hamano, Kenji; Hamilton, Andrew; Hamity, Guillermo Nicolas; Hamnett, Phillip George; Han, Liang; Hanagaki, Kazunori; Hanawa, Keita; Hance, Michael; Haney, Bijan; Hanke, Paul; Hanna, Remie; Hansen, Jørgen Beck; Hansen, Jorn Dines; Hansen, Maike Christina; Hansen, Peter Henrik; Hara, Kazuhiko; Hard, Andrew; Harenberg, Torsten; Hariri, Faten; Harkusha, Siarhei; Harrington, Robert; Harrison, Paul Fraser; Hartjes, Fred; Hasegawa, Makoto; Hasegawa, Yoji; Hasib, A; Hassani, Samira; Haug, Sigve; Hauser, Reiner; Hauswald, Lorenz; Havranek, Miroslav; Hawkes, Christopher; Hawkings, Richard John; Hawkins, Anthony David; Hayashi, Takayasu; Hayden, Daniel; Hays, Chris; Hays, Jonathan Michael; Hayward, Helen; Haywood, Stephen; Head, Simon; Heck, Tobias; Hedberg, Vincent; Heelan, Louise; Heim, Sarah; Heim, Timon; Heinemann, Beate; Heinrich, Lukas; Hejbal, Jiri; Helary, Louis; Hellman, Sten; Helsens, Clement; Henderson, James; Henderson, Robert; Heng, Yang; Henkelmann, Steffen; Henriques Correia, Ana Maria; Henrot-Versille, Sophie; Herbert, Geoffrey Henry; Hernández Jiménez, Yesenia; Herten, Gregor; Hertenberger, Ralf; Hervas, Luis; Hesketh, Gavin Grant; Hessey, Nigel; Hetherly, Jeffrey Wayne; Hickling, Robert; Higón-Rodriguez, Emilio; Hill, Ewan; Hill, John; Hiller, Karl Heinz; Hillier, Stephen; Hinchliffe, Ian; Hines, Elizabeth; Hinman, Rachel Reisner; Hirose, Minoru; Hirschbuehl, Dominic; Hobbs, John; Hod, Noam; Hodgkinson, Mark; Hodgson, Paul; Hoecker, Andreas; Hoeferkamp, Martin; Hoenig, Friedrich; Hohlfeld, Marc; Hohn, David; Holmes, Tova Ray; Homann, Michael; Hong, Tae Min; Hooberman, Benjamin Henry; Hopkins, Walter; Horii, Yasuyuki; Horton, Arthur James; Hostachy, Jean-Yves; Hou, Suen; Hoummada, Abdeslam; Howard, Jacob; Howarth, James; Hrabovsky, Miroslav; Hristova, Ivana; Hrivnac, Julius; Hryn'ova, Tetiana; Hrynevich, Aliaksei; Hsu, Catherine; Hsu, Pai-hsien Jennifer; Hsu, Shih-Chieh; Hu, Diedi; Hu, Qipeng; Huang, Yanping; Hubacek, Zdenek; Hubaut, Fabrice; Huegging, Fabian; Huffman, Todd Brian; Hughes, Emlyn; Hughes, Gareth; Huhtinen, Mika; Hülsing, Tobias Alexander; Huseynov, Nazim; Huston, Joey; Huth, John; Iacobucci, Giuseppe; Iakovidis, Georgios; Ibragimov, Iskander; Iconomidou-Fayard, Lydia; Ideal, Emma; Idrissi, Zineb; Iengo, Paolo; Igonkina, Olga; Iizawa, Tomoya; Ikegami, Yoichi; Ikeno, Masahiro; Ilchenko, Iurii; Iliadis, Dimitrios; Ilic, Nikolina; Ince, Tayfun; Introzzi, Gianluca; Ioannou, Pavlos; Iodice, Mauro; Iordanidou, Kalliopi; Ippolito, Valerio; Irles Quiles, Adrian; Isaksson, Charlie; Ishino, Masaya; Ishitsuka, Masaki; Ishmukhametov, Renat; Issever, Cigdem; Istin, Serhat; Iturbe Ponce, Julia Mariana; Iuppa, Roberto; Ivarsson, Jenny; Iwanski, Wieslaw; Iwasaki, Hiroyuki; Izen, Joseph; Izzo, Vincenzo; Jabbar, Samina; Jackson, Brett; Jackson, Matthew; Jackson, Paul; Jain, Vivek; Jakobi, Katharina Bianca; Jakobs, Karl; Jakobsen, Sune; Jakoubek, Tomas; Jamin, David Olivier; Jana, Dilip; Jansen, Eric; Jansky, Roland; Janssen, Jens; Janus, Michel; Jarlskog, Göran; Javadov, Namig; Javůrek, Tomáš; Jeanneau, Fabien; Jeanty, Laura; Jejelava, Juansher; Jeng, Geng-yuan; Jennens, David; Jenni, Peter; Jentzsch, Jennifer; Jeske, Carl; Jézéquel, Stéphane; Ji, Haoshuang; Jia, Jiangyong; Jiang, Hai; Jiang, Yi; Jiggins, Stephen; Jimenez Pena, Javier; Jin, Shan; Jinaru, Adam; Jinnouchi, Osamu; Johansson, Per; Johns, Kenneth; Johnson, William Joseph; Jon-And, Kerstin; Jones, Graham; Jones, Roger; Jones, Sarah; Jones, Tim; Jongmanns, Jan; Jorge, Pedro; Jovicevic, Jelena; Ju, Xiangyang; Juste Rozas, Aurelio; Köhler, Markus Konrad; Kaci, Mohammed; Kaczmarska, Anna; Kado, Marumi; Kagan, Harris; Kagan, Michael; Kahn, Sebastien Jonathan; Kajomovitz, Enrique; Kalderon, Charles William; Kaluza, Adam; Kama, Sami; Kamenshchikov, Andrey; Kanaya, Naoko; Kaneti, Steven; Kantserov, Vadim; Kanzaki, Junichi; Kaplan, Benjamin; Kaplan, Laser Seymour; Kapliy, Anton; Kar, Deepak; Karakostas, Konstantinos; Karamaoun, Andrew; Karastathis, Nikolaos; Kareem, Mohammad Jawad; Karentzos, Efstathios; Karnevskiy, Mikhail; Karpov, Sergey; Karpova, Zoya; Karthik, Krishnaiyengar; Kartvelishvili, Vakhtang; Karyukhin, Andrey; Kasahara, Kota; Kashif, Lashkar; Kass, Richard; Kastanas, Alex; Kataoka, Yousuke; Kato, Chikuma; Katre, Akshay; Katzy, Judith; Kawade, Kentaro; Kawagoe, Kiyotomo; Kawamoto, Tatsuo; Kawamura, Gen; Kazama, Shingo; Kazanin, Vassili; Keeler, Richard; Kehoe, Robert; Keller, John; Kempster, Jacob Julian; Keoshkerian, Houry; Kepka, Oldrich; Kerševan, Borut Paul; Kersten, Susanne; Keyes, Robert; Khalil-zada, Farkhad; Khandanyan, Hovhannes; Khanov, Alexander; Kharlamov, Alexey; Khoo, Teng Jian; Khovanskiy, Valery; Khramov, Evgeniy; Khubua, Jemal; Kido, Shogo; Kim, Hee Yeun; Kim, Shinhong; Kim, Young-Kee; Kimura, Naoki; Kind, Oliver Maria; King, Barry; King, Matthew; King, Samuel Burton; Kirk, Julie; Kiryunin, Andrey; Kishimoto, Tomoe; Kisielewska, Danuta; Kiss, Florian; Kiuchi, Kenji; Kivernyk, Oleh; Kladiva, Eduard; Klein, Matthew Henry; Klein, Max; Klein, Uta; Kleinknecht, Konrad; Klimek, Pawel; Klimentov, Alexei; Klingenberg, Reiner; Klinger, Joel Alexander; Klioutchnikova, Tatiana; Kluge, Eike-Erik; Kluit, Peter; Kluth, Stefan; Knapik, Joanna; Kneringer, Emmerich; Knoops, Edith; Knue, Andrea; Kobayashi, Aine; Kobayashi, Dai; Kobayashi, Tomio; Kobel, Michael; Kocian, Martin; Kodys, Peter; Koffas, Thomas; Koffeman, Els; Kogan, Lucy Anne; Kohlmann, Simon; Kohriki, Takashi; Koi, Tatsumi; Kolanoski, Hermann; Kolb, Mathis; Koletsou, Iro; Komar, Aston; Komori, Yuto; Kondo, Takahiko; Kondrashova, Nataliia; Köneke, Karsten; König, Adriaan; Kono, Takanori; Konoplich, Rostislav; Konstantinidis, Nikolaos; Kopeliansky, Revital; Koperny, Stefan; Köpke, Lutz; Kopp, Anna Katharina; Korcyl, Krzysztof; Kordas, Kostantinos; Korn, Andreas; Korol, Aleksandr; Korolkov, Ilya; Korolkova, Elena; Kortner, Oliver; Kortner, Sandra; Kosek, Tomas; Kostyukhin, Vadim; Kotov, Vladislav; Kotwal, Ashutosh; Kourkoumeli-Charalampidi, Athina; Kourkoumelis, Christine; Kouskoura, Vasiliki; Koutsman, Alex; Kowalewski, Robert Victor; Kowalski, Tadeusz; Kozanecki, Witold; Kozhin, Anatoly; Kramarenko, Viktor; Kramberger, Gregor; Krasnopevtsev, Dimitriy; Krasny, Mieczyslaw Witold; Krasznahorkay, Attila; Kraus, Jana; Kravchenko, Anton; Kretz, Moritz; Kretzschmar, Jan; Kreutzfeldt, Kristof; Krieger, Peter; Krizka, Karol; Kroeninger, Kevin; Kroha, Hubert; Kroll, Joe; Kroseberg, Juergen; Krstic, Jelena; Kruchonak, Uladzimir; Krüger, Hans; Krumnack, Nils; Kruse, Amanda; Kruse, Mark; Kruskal, Michael; Kubota, Takashi; Kucuk, Hilal; Kuday, Sinan; Kuechler, Jan Thomas; Kuehn, Susanne; Kugel, Andreas; Kuger, Fabian; Kuhl, Andrew; Kuhl, Thorsten; Kukhtin, Victor; Kukla, Romain; Kulchitsky, Yuri; Kuleshov, Sergey; Kuna, Marine; Kunigo, Takuto; Kupco, Alexander; Kurashige, Hisaya; Kurochkin, Yurii; Kus, Vlastimil; Kuwertz, Emma Sian; 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Leggett, Charles; Lehan, Allan; Lehmann Miotto, Giovanna; Lei, Xiaowen; Leight, William Axel; Leisos, Antonios; Leister, Andrew Gerard; Leite, Marco Aurelio Lisboa; Leitner, Rupert; Lellouch, Daniel; Lemmer, Boris; Leney, Katharine; Lenz, Tatjana; Lenzi, Bruno; Leone, Robert; Leone, Sandra; Leonidopoulos, Christos; Leontsinis, Stefanos; Leroy, Claude; Lester, Christopher; Levchenko, Mikhail; Levêque, Jessica; Levin, Daniel; Levinson, Lorne; Levy, Mark; Lewis, Adrian; Leyko, Agnieszka; Leyton, Michael; Li, Bing; Li, Haifeng; Li, Ho Ling; Li, Lei; Li, Liang; Li, Shu; Li, Xingguo; Li, Yichen; Liang, Zhijun; Liao, Hongbo; Liberti, Barbara; Liblong, Aaron; Lichard, Peter; Lie, Ki; Liebal, Jessica; Liebig, Wolfgang; Limbach, Christian; Limosani, Antonio; Lin, Simon; Lin, Tai-Hua; Lindquist, Brian Edward; Lipeles, Elliot; Lipniacka, Anna; Lisovyi, Mykhailo; Liss, Tony; Lissauer, David; Lister, Alison; Litke, Alan; Liu, Bo; Liu, Dong; Liu, Hao; Liu, Hongbin; Liu, Jian; Liu, Jianbei; Liu, Kun; Liu, Lulu; Liu, Miaoyuan; Liu, Minghui; Liu, Yanlin; Liu, Yanwen; Livan, Michele; Lleres, Annick; Llorente Merino, Javier; Lloyd, Stephen; Lo Sterzo, Francesco; Lobodzinska, Ewelina; Loch, Peter; Lockman, William; Loebinger, Fred; Loevschall-Jensen, Ask Emil; Loew, Kevin Michael; Loginov, Andrey; Lohse, Thomas; Lohwasser, Kristin; Lokajicek, Milos; Long, Brian Alexander; Long, Jonathan David; Long, Robin Eamonn; Looper, Kristina Anne; Lopes, Lourenco; Lopez Mateos, David; Lopez Paredes, Brais; Lopez Paz, Ivan; Lopez Solis, Alvaro; Lorenz, Jeanette; Lorenzo Martinez, Narei; Losada, Marta; Lösel, Philipp Jonathan; Lou, XinChou; Lounis, Abdenour; Love, Jeremy; Love, Peter; Lu, Haonan; Lu, Nan; Lubatti, Henry; Luci, Claudio; Lucotte, Arnaud; Luedtke, Christian; Luehring, Frederick; Lukas, Wolfgang; Luminari, Lamberto; Lundberg, Olof; Lund-Jensen, Bengt; Lynn, David; Lysak, Roman; Lytken, Else; Ma, Hong; Ma, Lian Liang; Maccarrone, Giovanni; Macchiolo, Anna; Macdonald, Calum Michael; Maček, Boštjan; Machado Miguens, Joana; Madaffari, Daniele; Madar, Romain; Maddocks, Harvey Jonathan; Mader, Wolfgang; Madsen, Alexander; Maeda, Junpei; Maeland, Steffen; Maeno, Tadashi; Maevskiy, Artem; Magradze, Erekle; Mahlstedt, Joern; Maiani, Camilla; Maidantchik, Carmen; Maier, Andreas Alexander; Maier, Thomas; Maio, Amélia; Majewski, Stephanie; Makida, Yasuhiro; Makovec, Nikola; Malaescu, Bogdan; Malecki, Pawel; Maleev, Victor; Malek, Fairouz; Mallik, Usha; Malon, David; Malone, Caitlin; Maltezos, Stavros; Malyshev, Vladimir; Malyukov, Sergei; Mamuzic, Judita; Mancini, Giada; Mandelli, Beatrice; Mandelli, Luciano; Mandić, Igor; Maneira, José; Manhaes de Andrade Filho, Luciano; Manjarres Ramos, Joany; Mann, Alexander; Mansoulie, Bruno; Mantifel, Rodger; Mantoani, Matteo; Manzoni, Stefano; Mapelli, Livio; March, Luis; Marchiori, Giovanni; Marcisovsky, Michal; Marjanovic, Marija; Marley, Daniel; Marroquim, Fernando; Marsden, Stephen Philip; Marshall, Zach; Marti, Lukas Fritz; Marti-Garcia, Salvador; Martin, Brian Thomas; Martin, Tim; Martin, Victoria Jane; Martin dit Latour, Bertrand; Martinez, Mario; Martin-Haugh, Stewart; Martoiu, Victor Sorin; Martyniuk, Alex; Marx, Marilyn; Marzano, Francesco; Marzin, Antoine; Masetti, Lucia; Mashimo, Tetsuro; Mashinistov, Ruslan; Masik, Jiri; Maslennikov, Alexey; Massa, Ignazio; Massa, Lorenzo; Mastrandrea, Paolo; Mastroberardino, Anna; Masubuchi, Tatsuya; Mättig, Peter; Mattmann, Johannes; Maurer, Julien; Maxfield, Stephen; Maximov, Dmitriy; Mazini, Rachid; Mazza, Simone Michele; Mc Fadden, Neil Christopher; Mc Goldrick, Garrin; Mc Kee, Shawn Patrick; McCarn, Allison; McCarthy, Robert; McCarthy, Tom; McFarlane, Kenneth; Mcfayden, Josh; Mchedlidze, Gvantsa; McMahon, Steve; McPherson, Robert; Medinnis, Michael; Meehan, Samuel; Mehlhase, Sascha; Mehta, Andrew; Meier, Karlheinz; Meineck, Christian; Meirose, Bernhard; Mellado Garcia, Bruce Rafael; Meloni, Federico; Mengarelli, Alberto; Menke, Sven; Meoni, Evelin; Mercurio, Kevin Michael; Mergelmeyer, Sebastian; Mermod, Philippe; Merola, Leonardo; Meroni, Chiara; Merritt, Frank; Messina, Andrea; Metcalfe, Jessica; Mete, Alaettin Serhan; Meyer, Carsten; Meyer, Christopher; Meyer, Jean-Pierre; Meyer, Jochen; Meyer Zu Theenhausen, Hanno; Middleton, Robin; Miglioranzi, Silvia; Mijović, Liza; Mikenberg, Giora; Mikestikova, Marcela; Mikuž, Marko; Milesi, Marco; Milic, Adriana; Miller, David; Mills, Corrinne; Milov, Alexander; Milstead, David; Minaenko, Andrey; Minami, Yuto; Minashvili, Irakli; Mincer, Allen; Mindur, Bartosz; Mineev, Mikhail; Ming, Yao; Mir, Lluisa-Maria; Mistry, Khilesh; Mitani, Takashi; Mitrevski, Jovan; Mitsou, Vasiliki A; Miucci, Antonio; Miyagawa, Paul; Mjörnmark, Jan-Ulf; Moa, Torbjoern; Mochizuki, Kazuya; Mohapatra, Soumya; Mohr, Wolfgang; Molander, Simon; Moles-Valls, Regina; Monden, Ryutaro; Mondragon, Matthew Craig; Mönig, Klaus; Monk, James; Monnier, Emmanuel; Montalbano, Alyssa; Montejo Berlingen, Javier; Monticelli, Fernando; Monzani, Simone; Moore, Roger; Morange, Nicolas; Moreno, Deywis; Moreno Llácer, María; Morettini, Paolo; Mori, Daniel; Mori, Tatsuya; Morii, Masahiro; Morinaga, Masahiro; Morisbak, Vanja; Moritz, Sebastian; Morley, Anthony Keith; Mornacchi, Giuseppe; Morris, John; Mortensen, Simon Stark; Morvaj, Ljiljana; Mosidze, Maia; Moss, Josh; Motohashi, Kazuki; Mount, Richard; Mountricha, Eleni; Mouraviev, Sergei; Moyse, Edward; Muanza, Steve; Mudd, Richard; Mueller, Felix; Mueller, James; Mueller, Ralph Soeren Peter; Mueller, Thibaut; Muenstermann, Daniel; Mullen, Paul; Mullier, Geoffrey; Munoz Sanchez, Francisca Javiela; Murillo Quijada, Javier Alberto; Murray, Bill; Musheghyan, Haykuhi; Myagkov, Alexey; Myska, Miroslav; Nachman, Benjamin Philip; Nackenhorst, Olaf; Nadal, Jordi; Nagai, Koichi; Nagai, Ryo; Nagai, Yoshikazu; Nagano, Kunihiro; Nagasaka, Yasushi; Nagata, Kazuki; Nagel, Martin; Nagy, Elemer; Nairz, Armin Michael; Nakahama, Yu; Nakamura, Koji; Nakamura, Tomoaki; Nakano, Itsuo; Namasivayam, Harisankar; Naranjo Garcia, Roger Felipe; Narayan, Rohin; Narrias Villar, Daniel Isaac; Naryshkin, Iouri; Naumann, Thomas; Navarro, Gabriela; Nayyar, Ruchika; Neal, Homer; Nechaeva, Polina; Neep, Thomas James; Nef, Pascal Daniel; Negri, Andrea; Negrini, Matteo; Nektarijevic, Snezana; Nellist, Clara; Nelson, Andrew; Nemecek, Stanislav; Nemethy, Peter; Nepomuceno, Andre Asevedo; Nessi, Marzio; Neubauer, Mark; Neumann, Manuel; Neves, Ricardo; Nevski, Pavel; Newman, Paul; Nguyen, Duong Hai; Nickerson, Richard; Nicolaidou, Rosy; Nicquevert, Bertrand; Nielsen, Jason; Nikiforov, Andriy; Nikolaenko, Vladimir; Nikolic-Audit, Irena; Nikolopoulos, Konstantinos; Nilsen, Jon Kerr; Nilsson, Paul; Ninomiya, Yoichi; Nisati, Aleandro; Nisius, Richard; Nobe, Takuya; Nodulman, Lawrence; Nomachi, Masaharu; Nomidis, Ioannis; Nooney, Tamsin; Norberg, Scarlet; Nordberg, Markus; Novgorodova, Olga; Nowak, Sebastian; Nozaki, Mitsuaki; Nozka, Libor; Ntekas, Konstantinos; Nurse, Emily; Nuti, Francesco; O'grady, Fionnbarr; O'Neil, Dugan; O'Shea, Val; Oakham, Gerald; Oberlack, Horst; Obermann, Theresa; Ocariz, Jose; Ochi, Atsuhiko; Ochoa, Ines; Ochoa-Ricoux, Juan Pedro; Oda, Susumu; Odaka, Shigeru; Ogren, Harold; Oh, Alexander; Oh, Seog; Ohm, Christian; Ohman, Henrik; Oide, Hideyuki; Okawa, Hideki; Okumura, Yasuyuki; Okuyama, Toyonobu; Olariu, Albert; Oleiro Seabra, Luis Filipe; Olivares Pino, Sebastian Andres; Oliveira Damazio, Denis; Olszewski, Andrzej; Olszowska, Jolanta; Onofre, António; Onogi, Kouta; Onyisi, Peter; Oram, Christopher; Oreglia, Mark; Oren, Yona; Orestano, Domizia; Orlando, Nicola; Orr, Robert; Osculati, Bianca; Ospanov, Rustem; Otero y Garzon, Gustavo; Otono, Hidetoshi; Ouchrif, Mohamed; Ould-Saada, Farid; Ouraou, Ahmimed; Oussoren, Koen Pieter; Ouyang, Qun; Ovcharova, Ana; Owen, Mark; Owen, Rhys Edward; Ozcan, Veysi Erkcan; Ozturk, Nurcan; Pachal, Katherine; Pacheco Pages, Andres; Padilla Aranda, Cristobal; Pagáčová, Martina; Pagan Griso, Simone; Paige, Frank; Pais, Preema; Pajchel, Katarina; Palacino, Gabriel; Palestini, Sandro; Palka, Marek; Pallin, Dominique; Palma, Alberto; Panagiotopoulou, Evgenia; Pandini, Carlo Enrico; Panduro Vazquez, William; Pani, Priscilla; Panitkin, Sergey; Pantea, Dan; Paolozzi, Lorenzo; Papadopoulou, Theodora; Papageorgiou, Konstantinos; Paramonov, Alexander; Paredes Hernandez, Daniela; Parker, Michael Andrew; Parker, Kerry Ann; Parodi, Fabrizio; Parsons, John; Parzefall, Ulrich; Pascuzzi, Vincent; Pasqualucci, Enrico; Passaggio, Stefano; Pastore, Fernanda; Pastore, Francesca; Pásztor, Gabriella; Pataraia, Sophio; Patel, Nikhul; Pater, Joleen; Pauly, Thilo; Pearce, James; Pearson, Benjamin; Pedersen, Lars Egholm; Pedersen, Maiken; Pedraza Lopez, Sebastian; Pedro, Rute; Peleganchuk, Sergey; Pelikan, Daniel; Penc, Ondrej; Peng, Cong; Peng, Haiping; Penning, Bjoern; Penwell, John; Perepelitsa, Dennis; Perez Codina, Estel; Perini, Laura; Pernegger, Heinz; Perrella, Sabrina; Peschke, Richard; Peshekhonov, Vladimir; Peters, Krisztian; Peters, Yvonne; Petersen, Brian; Petersen, Troels; Petit, Elisabeth; Petridis, Andreas; Petridou, Chariclia; Petroff, Pierre; Petrolo, Emilio; Petrucci, Fabrizio; Pettersson, Nora Emilia; Peyaud, Alan; Pezoa, Raquel; Phillips, Peter William; Piacquadio, Giacinto; Pianori, Elisabetta; Picazio, Attilio; Piccaro, Elisa; Piccinini, Maurizio; Pickering, Mark Andrew; Piegaia, Ricardo; Pilcher, James; Pilkington, Andrew; Pin, Arnaud Willy J; Pina, João Antonio; Pinamonti, Michele; Pinfold, James; Pingel, Almut; Pires, Sylvestre; Pirumov, Hayk; Pitt, Michael; Plazak, Lukas; Pleier, Marc-Andre; Pleskot, Vojtech; Plotnikova, Elena; Plucinski, Pawel; Pluth, Daniel; Poettgen, Ruth; Poggioli, Luc; Pohl, David-leon; Polesello, Giacomo; Poley, Anne-luise; Policicchio, Antonio; Polifka, Richard; Polini, Alessandro; Pollard, Christopher Samuel; Polychronakos, Venetios; Pommès, Kathy; Pontecorvo, Ludovico; Pope, Bernard; Popeneciu, Gabriel Alexandru; Popovic, Dragan; Poppleton, Alan; Pospisil, Stanislav; Potamianos, Karolos; Potrap, Igor; Potter, Christina; Potter, Christopher; Poulard, Gilbert; Poveda, Joaquin; Pozdnyakov, Valery; Pozo Astigarraga, Mikel Eukeni; Pralavorio, Pascal; Pranko, Aliaksandr; Prell, Soeren; Price, Darren; Price, Lawrence; Primavera, Margherita; Prince, Sebastien; Proissl, Manuel; Prokofiev, Kirill; Prokoshin, Fedor; Protopapadaki, Eftychia-sofia; Protopopescu, Serban; Proudfoot, James; Przybycien, Mariusz; Puddu, Daniele; Puldon, David; Purohit, Milind; Puzo, Patrick; Qian, Jianming; Qin, Gang; Qin, Yang; Quadt, Arnulf; Quarrie, David; Quayle, William; Queitsch-Maitland, Michaela; Quilty, Donnchadha; Raddum, Silje; Radeka, Veljko; Radescu, Voica; Radhakrishnan, Sooraj Krishnan; Radloff, Peter; Rados, Pere; Ragusa, Francesco; Rahal, Ghita; Rajagopalan, Srinivasan; Rammensee, Michael; Rangel-Smith, Camila; Rauscher, Felix; Rave, Stefan; Ravenscroft, Thomas; Raymond, Michel; Read, Alexander Lincoln; Readioff, Nathan Peter; Rebuzzi, Daniela; Redelbach, Andreas; Redlinger, George; Reece, Ryan; Reeves, Kendall; Rehnisch, Laura; Reichert, Joseph; Reisin, Hernan; Rembser, Christoph; Ren, Huan; Rescigno, Marco; Resconi, Silvia; Rezanova, Olga; Reznicek, Pavel; Rezvani, Reyhaneh; Richter, Robert; Richter, Stefan; Richter-Was, Elzbieta; Ricken, Oliver; Ridel, Melissa; Rieck, Patrick; Riegel, Christian Johann; Rieger, Julia; Rifki, Othmane; Rijssenbeek, Michael; Rimoldi, Adele; Rinaldi, Lorenzo; Ristić, Branislav; Ritsch, Elmar; Riu, Imma; Rizatdinova, Flera; Rizvi, Eram; Robertson, Steven; Robichaud-Veronneau, Andree; Robinson, Dave; Robinson, James; Robson, Aidan; Roda, Chiara; Rodina, Yulia; Rodriguez Perez, Andrea; Roe, Shaun; Rogan, Christopher Sean; Røhne, Ole; Romaniouk, Anatoli; Romano, Marino; Romano Saez, Silvestre Marino; Romero Adam, Elena; Rompotis, Nikolaos; Ronzani, Manfredi; Roos, Lydia; Ros, Eduardo; Rosati, Stefano; Rosbach, Kilian; Rose, Peyton; Rosenthal, Oliver; Rossetti, Valerio; Rossi, Elvira; Rossi, Leonardo Paolo; Rosten, Jonatan; Rosten, Rachel; Rotaru, Marina; Roth, Itamar; Rothberg, Joseph; Rousseau, David; Royon, Christophe; Rozanov, Alexandre; Rozen, Yoram; Ruan, Xifeng; Rubbo, Francesco; Rubinskiy, Igor; Rud, Viacheslav; Rudolph, Matthew Scott; Rühr, Frederik; Ruiz-Martinez, Aranzazu; Rurikova, Zuzana; Rusakovich, Nikolai; Ruschke, Alexander; Russell, Heather; Rutherfoord, John; Ruthmann, Nils; Ryabov, Yury; Rybar, Martin; Rybkin, Grigori; Ryder, Nick; Ryzhov, Andrey; Saavedra, Aldo; Sabato, Gabriele; Sacerdoti, Sabrina; Sadrozinski, Hartmut; Sadykov, Renat; Safai Tehrani, Francesco; Saha, Puja; Sahinsoy, Merve; Saimpert, Matthias; Saito, Tomoyuki; Sakamoto, Hiroshi; Sakurai, Yuki; Salamanna, Giuseppe; Salamon, Andrea; Salazar Loyola, Javier Esteban; Salek, David; Sales De Bruin, Pedro Henrique; Salihagic, Denis; Salnikov, Andrei; Salt, José; Salvatore, Daniela; Salvatore, Pasquale Fabrizio; Salvucci, Antonio; Salzburger, Andreas; Sammel, Dirk; Sampsonidis, Dimitrios; Sanchez, Arturo; Sánchez, Javier; Sanchez Martinez, Victoria; Sandaker, Heidi; Sandbach, Ruth Laura; Sander, Heinz Georg; Sanders, Michiel; Sandhoff, Marisa; Sandoval, Carlos; Sandstroem, Rikard; Sankey, Dave; Sannino, Mario; Sansoni, Andrea; Santoni, Claudio; Santonico, Rinaldo; Santos, Helena; Santoyo Castillo, Itzebelt; Sapp, Kevin; Sapronov, Andrey; Saraiva, João; Sarrazin, Bjorn; Sasaki, Osamu; Sasaki, Yuichi; Sato, Koji; Sauvage, Gilles; Sauvan, Emmanuel; Savage, Graham; Savard, Pierre; Sawyer, Craig; Sawyer, Lee; Saxon, James; Sbarra, Carla; Sbrizzi, Antonio; Scanlon, Tim; Scannicchio, Diana; Scarcella, Mark; Scarfone, Valerio; Schaarschmidt, Jana; Schacht, Peter; Schaefer, Douglas; Schaefer, Ralph; Schaeffer, Jan; Schaepe, Steffen; Schaetzel, Sebastian; Schäfer, Uli; Schaffer, Arthur; Schaile, Dorothee; Schamberger, R Dean; Scharf, Veit; Schegelsky, Valery; Scheirich, Daniel; Schernau, Michael; Schiavi, Carlo; Schillo, Christian; Schioppa, Marco; Schlenker, Stefan; Schmieden, Kristof; Schmitt, Christian; Schmitt, Sebastian; Schmitt, Stefan; Schmitz, Simon; Schneider, Basil; Schnellbach, Yan Jie; Schnoor, Ulrike; Schoeffel, Laurent; Schoening, Andre; Schoenrock, Bradley Daniel; Schopf, Elisabeth; Schorlemmer, Andre Lukas; Schott, Matthias; Schouten, Doug; Schovancova, Jaroslava; Schramm, Steven; Schreyer, Manuel; Schuh, Natascha; Schultens, Martin Johannes; Schultz-Coulon, Hans-Christian; Schulz, Holger; Schumacher, Markus; Schumm, Bruce; Schune, Philippe; Schwanenberger, Christian; Schwartzman, Ariel; Schwarz, Thomas Andrew; Schwegler, Philipp; Schweiger, Hansdieter; Schwemling, Philippe; Schwienhorst, Reinhard; Schwindling, Jerome; Schwindt, Thomas; Sciolla, Gabriella; Scuri, Fabrizio; Scutti, Federico; Searcy, Jacob; Seema, Pienpen; Seidel, Sally; Seiden, Abraham; Seifert, Frank; Seixas, José; Sekhniaidze, Givi; Sekhon, Karishma; Sekula, Stephen; Seliverstov, Dmitry; Semprini-Cesari, Nicola; Serfon, Cedric; Serin, Laurent; Serkin, Leonid; Sessa, Marco; Seuster, Rolf; Severini, Horst; Sfiligoj, Tina; Sforza, Federico; Sfyrla, Anna; Shabalina, Elizaveta; Shaikh, Nabila Wahab; Shan, Lianyou; Shang, Ruo-yu; Shank, James; Shapiro, Marjorie; Shatalov, Pavel; Shaw, Kate; Shaw, Savanna Marie; Shcherbakova, Anna; Shehu, Ciwake Yusufu; Sherwood, Peter; Shi, Liaoshan; Shimizu, Shima; Shimmin, Chase Owen; Shimojima, Makoto; Shiyakova, Mariya; Shmeleva, Alevtina; Shoaleh Saadi, Diane; Shochet, Mel; Shojaii, Seyedruhollah; Shrestha, Suyog; Shulga, Evgeny; Shupe, Michael; Sicho, Petr; Sidebo, Per Edvin; Sidiropoulou, Ourania; Sidorov, Dmitri; Sidoti, Antonio; Siegert, Frank; Sijacki, Djordje; Silva, José; Silverstein, Samuel; Simak, Vladislav; Simard, Olivier; Simic, Ljiljana; Simion, Stefan; Simioni, Eduard; Simmons, Brinick; Simon, Dorian; Simon, Manuel; Sinervo, Pekka; Sinev, Nikolai; Sioli, Maximiliano; Siragusa, Giovanni; Sivoklokov, Serguei; Sjölin, Jörgen; Sjursen, Therese; Skinner, Malcolm Bruce; Skottowe, Hugh Philip; Skubic, Patrick; Slater, Mark; Slavicek, Tomas; Slawinska, Magdalena; Sliwa, Krzysztof; Smakhtin, Vladimir; Smart, Ben; Smestad, Lillian; Smirnov, Sergei; Smirnov, Yury; Smirnova, Lidia; Smirnova, Oxana; Smith, Matthew; Smith, Russell; Smizanska, Maria; Smolek, Karel; Snesarev, Andrei; Snidero, Giacomo; Snyder, Scott; Sobie, Randall; Socher, Felix; Soffer, Abner; Soh, Dart-yin; Sokhrannyi, Grygorii; Solans Sanchez, Carlos; Solar, Michael; Soldatov, Evgeny; Soldevila, Urmila; Solodkov, Alexander; Soloshenko, Alexei; Solovyanov, Oleg; Solovyev, Victor; Sommer, Philip; Song, Hong Ye; Soni, Nitesh; Sood, Alexander; Sopczak, Andre; Sopko, Vit; Sorin, Veronica; Sosa, David; Sotiropoulou, Calliope Louisa; Soualah, Rachik; Soukharev, Andrey; South, David; Sowden, Benjamin; Spagnolo, Stefania; Spalla, Margherita; Spangenberg, Martin; Spanò, Francesco; Sperlich, Dennis; Spettel, Fabian; Spighi, Roberto; Spigo, Giancarlo; Spiller, Laurence Anthony; Spousta, Martin; St Denis, Richard Dante; Stabile, Alberto; Staerz, Steffen; Stahlman, Jonathan; Stamen, Rainer; Stamm, Soren; Stanecka, Ewa; Stanek, Robert; Stanescu, Cristian; Stanescu-Bellu, Madalina; Stanitzki, Marcel Michael; Stapnes, Steinar; Starchenko, Evgeny; Stark, Giordon; Stark, Jan; Staroba, Pavel; Starovoitov, Pavel; Staszewski, Rafal; Steinberg, Peter; Stelzer, Bernd; Stelzer, Harald Joerg; Stelzer-Chilton, Oliver; Stenzel, Hasko; Stewart, Graeme; Stillings, Jan Andre; Stockton, Mark; Stoebe, Michael; Stoicea, Gabriel; Stolte, Philipp; Stonjek, Stefan; Stradling, Alden; Straessner, Arno; Stramaglia, Maria Elena; Strandberg, Jonas; Strandberg, Sara; Strandlie, Are; Strauss, Michael; Strizenec, Pavol; Ströhmer, Raimund; Strom, David; Stroynowski, Ryszard; Strubig, Antonia; Stucci, Stefania Antonia; Stugu, Bjarne; Styles, Nicholas Adam; Su, Dong; Su, Jun; Subramaniam, Rajivalochan; Suchek, Stanislav; Sugaya, Yorihito; Suk, Michal; Sulin, Vladimir; Sultansoy, Saleh; Sumida, Toshi; Sun, Siyuan; Sun, Xiaohu; Sundermann, Jan Erik; Suruliz, Kerim; Susinno, Giancarlo; Sutton, Mark; Suzuki, Shota; Svatos, Michal; Swiatlowski, Maximilian; Sykora, Ivan; Sykora, Tomas; Ta, Duc; Taccini, Cecilia; Tackmann, Kerstin; Taenzer, Joe; Taffard, Anyes; Tafirout, Reda; Taiblum, Nimrod; Takai, Helio; Takashima, Ryuichi; Takeda, Hiroshi; Takeshita, Tohru; Takubo, Yosuke; Talby, Mossadek; Talyshev, Alexey; Tam, Jason; Tan, Kong Guan; Tanaka, Junichi; Tanaka, Reisaburo; Tanaka, Shuji; Tannenwald, Benjamin Bordy; Tapia Araya, Sebastian; Tapprogge, Stefan; Tarem, Shlomit; Tartarelli, Giuseppe Francesco; Tas, Petr; Tasevsky, Marek; Tashiro, Takuya; Tassi, Enrico; Tavares Delgado, Ademar; Tayalati, Yahya; Taylor, Aaron; Taylor, Geoffrey; Taylor, Pierre Thor Elliot; Taylor, Wendy; Teischinger, Florian Alfred; Teixeira-Dias, Pedro; Temming, Kim Katrin; Temple, Darren; Ten Kate, Herman; Teng, Ping-Kun; Teoh, Jia Jian; Tepel, Fabian-Phillipp; Terada, Susumu; Terashi, Koji; Terron, Juan; Terzo, Stefano; Testa, Marianna; Teuscher, Richard; Theveneaux-Pelzer, Timothée; Thomas, Juergen; Thomas-Wilsker, Joshuha; Thompson, Emily; Thompson, Paul; Thompson, Ray; Thompson, Stan; Thomsen, Lotte Ansgaard; Thomson, Evelyn; Thomson, Mark; Tibbetts, Mark James; Ticse Torres, Royer Edson; Tikhomirov, Vladimir; Tikhonov, Yury; Timoshenko, Sergey; Tiouchichine, Elodie; Tipton, Paul; Tisserant, Sylvain; Todome, Kazuki; Todorov, Theodore; Todorova-Nova, Sharka; Tojo, Junji; Tokár, Stanislav; Tokushuku, Katsuo; Tolley, Emma; Tomlinson, Lee; Tomoto, Makoto; Tompkins, Lauren; Toms, Konstantin; Tong, Baojia(Tony); Torrence, Eric; Torres, Heberth; Torró Pastor, Emma; Toth, Jozsef; Touchard, Francois; Tovey, Daniel; Trefzger, Thomas; Tremblet, Louis; Tricoli, Alessandro; Trigger, Isabel Marian; Trincaz-Duvoid, Sophie; Tripiana, Martin; Trischuk, William; Trocmé, Benjamin; Trofymov, Artur; Troncon, Clara; Trottier-McDonald, Michel; Trovatelli, Monica; Truong, Loan; Trzebinski, Maciej; Trzupek, Adam; Tseng, Jeffrey; Tsiareshka, Pavel; Tsipolitis, Georgios; Tsirintanis, Nikolaos; Tsiskaridze, Shota; Tsiskaridze, Vakhtang; Tskhadadze, Edisher; Tsui, Ka Ming; Tsukerman, Ilya; Tsulaia, Vakhtang; Tsuno, Soshi; Tsybychev, Dmitri; Tudorache, Alexandra; Tudorache, Valentina; Tuna, Alexander Naip; Tupputi, Salvatore; Turchikhin, Semen; Turecek, Daniel; Turgeman, Daniel; Turra, Ruggero; Turvey, Andrew John; Tuts, Michael; Tylmad, Maja; Tyndel, Mike; Ueda, Ikuo; Ueno, Ryuichi; Ughetto, Michael; Ukegawa, Fumihiko; Unal, Guillaume; Undrus, Alexander; Unel, Gokhan; Ungaro, Francesca; Unno, Yoshinobu; Unverdorben, Christopher; Urban, Jozef; Urquijo, Phillip; Urrejola, Pedro; Usai, Giulio; Usanova, Anna; Vacavant, Laurent; Vacek, Vaclav; Vachon, Brigitte; Valderanis, Chrysostomos; Valencic, Nika; Valentinetti, Sara; Valero, Alberto; Valery, Loic; Valkar, Stefan; Vallecorsa, Sofia; Valls Ferrer, Juan Antonio; Van Den Wollenberg, Wouter; Van Der Deijl, Pieter; van der Geer, Rogier; van der Graaf, Harry; van Eldik, Niels; van Gemmeren, Peter; Van Nieuwkoop, Jacobus; van Vulpen, Ivo; van Woerden, Marius Cornelis; Vanadia, Marco; Vandelli, Wainer; Vanguri, Rami; Vaniachine, Alexandre; Vardanyan, Gagik; Vari, Riccardo; Varnes, Erich; Varol, Tulin; Varouchas, Dimitris; Vartapetian, Armen; Varvell, Kevin; Vazeille, Francois; Vazquez Schroeder, Tamara; Veatch, Jason; Veloce, Laurelle Maria; Veloso, Filipe; Veneziano, Stefano; Ventura, Andrea; Venturi, Manuela; Venturi, Nicola; Venturini, Alessio; Vercesi, Valerio; Verducci, Monica; Verkerke, Wouter; Vermeulen, Jos; Vest, Anja; Vetterli, Michel; Viazlo, Oleksandr; Vichou, Irene; Vickey, Trevor; Vickey Boeriu, Oana Elena; Viehhauser, Georg; Viel, Simon; Vigne, Ralph; Villa, Mauro; Villaplana Perez, Miguel; Vilucchi, Elisabetta; Vincter, Manuella; Vinogradov, Vladimir; Vivarelli, Iacopo; Vlachos, Sotirios; Vladoiu, Dan; Vlasak, Michal; Vogel, Marcelo; Vokac, Petr; Volpi, Guido; Volpi, Matteo; von der Schmitt, Hans; von Toerne, Eckhard; Vorobel, Vit; Vorobev, Konstantin; Vos, Marcel; Voss, Rudiger; Vossebeld, Joost; Vranjes, Nenad; Vranjes Milosavljevic, Marija; Vrba, Vaclav; Vreeswijk, Marcel; Vuillermet, Raphael; Vukotic, Ilija; Vykydal, Zdenek; Wagner, Peter; Wagner, Wolfgang; Wahlberg, Hernan; Wahrmund, Sebastian; Wakabayashi, Jun; Walder, James; Walker, Rodney; Walkowiak, Wolfgang; Wallangen, Veronica; Wang, Chao; Wang, Chao; Wang, Fuquan; Wang, Haichen; Wang, Hulin; Wang, Jike; Wang, Jin; Wang, Kuhan; Wang, Rui; Wang, Song-Ming; Wang, Tan; Wang, Tingting; Wang, Xiaoxiao; Wanotayaroj, Chaowaroj; Warburton, Andreas; Ward, Patricia; Wardrope, David Robert; Washbrook, Andrew; Watkins, Peter; Watson, Alan; Watson, Ian; Watson, Miriam; Watts, Gordon; Watts, Stephen; Waugh, Ben; Webb, Samuel; Weber, Michele; Weber, Stefan Wolf; Webster, Jordan S; Weidberg, Anthony; Weinert, Benjamin; Weingarten, Jens; Weiser, Christian; Weits, Hartger; Wells, Phillippa; Wenaus, Torre; Wengler, Thorsten; Wenig, Siegfried; Wermes, Norbert; Werner, Matthias; Werner, Per; Wessels, Martin; Wetter, Jeffrey; Whalen, Kathleen; Wharton, Andrew Mark; White, Andrew; White, Martin; White, Ryan; White, Sebastian; Whiteson, Daniel; Wickens, Fred; Wiedenmann, Werner; Wielers, Monika; Wienemann, Peter; Wiglesworth, Craig; Wiik-Fuchs, Liv Antje Mari; Wildauer, Andreas; Wilkens, Henric George; Williams, Hugh; Williams, Sarah; Willis, Christopher; Willocq, Stephane; Wilson, John; Wingerter-Seez, Isabelle; Winklmeier, Frank; Winter, Benedict Tobias; Wittgen, Matthias; Wittkowski, Josephine; Wollstadt, Simon Jakob; Wolter, Marcin Wladyslaw; Wolters, Helmut; Wosiek, Barbara; Wotschack, Jorg; Woudstra, Martin; Wozniak, Krzysztof; Wu, Mengqing; Wu, Miles; Wu, Sau Lan; Wu, Xin; Wu, Yusheng; Wyatt, Terry Richard; Wynne, Benjamin; Xella, Stefania; Xu, Da; Xu, Lailin; Yabsley, Bruce; Yacoob, Sahal; Yakabe, Ryota; Yamaguchi, Daiki; Yamaguchi, Yohei; Yamamoto, Akira; Yamamoto, Shimpei; Yamanaka, Takashi; Yamauchi, Katsuya; Yamazaki, Yuji; Yan, Zhen; Yang, Haijun; Yang, Hongtao; Yang, Yi; Yang, Zongchang; Yao, Weiming; Yap, Yee Chinn; Yasu, Yoshiji; Yatsenko, Elena; Yau Wong, Kaven Henry; Ye, Jingbo; Ye, Shuwei; Yeletskikh, Ivan; Yen, Andy L; Yildirim, Eda; Yorita, Kohei; Yoshida, Rikutaro; Yoshihara, Keisuke; Young, Charles; Young, Christopher John; Youssef, Saul; Yu, David Ren-Hwa; Yu, Jaehoon; Yu, Jiaming; Yu, Jie; Yuan, Li; Yuen, Stephanie P; Yusuff, Imran; Zabinski, Bartlomiej; Zaidan, Remi; Zaitsev, Alexander; Zakharchuk, Nataliia; Zalieckas, Justas; Zaman, Aungshuman; Zambito, Stefano; Zanello, Lucia; Zanzi, Daniele; Zeitnitz, Christian; Zeman, Martin; Zemla, Andrzej; Zeng, Jian Cong; Zeng, Qi; Zengel, Keith; Zenin, Oleg; Ženiš, Tibor; Zerwas, Dirk; Zhang, Dongliang; Zhang, Fangzhou; Zhang, Guangyi; Zhang, Huijun; Zhang, Jinlong; Zhang, Lei; Zhang, Rui; Zhang, Ruiqi; Zhang, Xueyao; Zhang, Zhiqing; Zhao, Xiandong; Zhao, Yongke; Zhao, Zhengguo; Zhemchugov, Alexey; Zhong, Jiahang; Zhou, Bing; Zhou, Chen; Zhou, Lei; Zhou, Li; Zhou, Mingliang; Zhou, Ning; Zhu, Cheng Guang; Zhu, Hongbo; Zhu, Junjie; Zhu, Yingchun; Zhuang, Xuai; Zhukov, Konstantin; Zibell, Andre; Zieminska, Daria; Zimine, Nikolai; Zimmermann, Christoph; Zimmermann, Stephanie; Zinonos, Zinonas; Zinser, Markus; Ziolkowski, Michael; Živković, Lidija; Zobernig, Georg; Zoccoli, Antonio; zur Nedden, Martin; Zurzolo, Giovanni; Zwalinski, Lukasz

    2016-08-08

    A search for singly produced vector-like $Q$ quarks, where $Q$ can be either a $T$ quark with charge $+2/3$ or a $Y$ quark with charge $-4/3$, is performed in proton--proton collisions recorded with the ATLAS detector at the LHC. The dataset corresponds to an integrated luminosity of 20.3 fb$^{-1}$ and was produced with a centre-of-mass energy of $\\sqrt{s}=8$ TeV. This analysis targets $Q \\to Wb$ decays where the $W$ boson decays leptonically. A veto on massive large-radius jets is used to reject the dominant $t\\bar{t}$ background. The reconstructed $Q$-candidate mass, ranging from 0.4 to 1.2 TeV, is used in the search to discriminate signal from background processes. No significant deviation from the Standard Model expectation is observed, and limits are set on the $Q \\to Wb$ cross-section times branching ratio. The results are also interpreted as limits on the $QWb$ coupling and the mixing with the Standard Model sector for a singlet $T$ quark or a $Y$ quark from a doublet. $T$ quarks with masses below 0.95...

  1. Valuing avoided morbidity using meta-regression analysis: what can health status measures and QALYs tell us about WTP?

    Science.gov (United States)

    Van Houtven, George; Powers, John; Jessup, Amber; Yang, Jui-Chen

    2006-08-01

    Many economists argue that willingness-to-pay (WTP) measures are most appropriate for assessing the welfare effects of health changes. Nevertheless, the health evaluation literature is still dominated by studies estimating nonmonetary health status measures (HSMs), which are often used to assess changes in quality-adjusted life years (QALYs). Using meta-regression analysis, this paper combines results from both WTP and HSM studies applied to acute morbidity, and it tests whether a systematic relationship exists between HSM and WTP estimates. We analyze over 230 WTP estimates from 17 different studies and find evidence that QALY-based estimates of illness severity--as measured by the Quality of Well-Being (QWB) Scale--are significant factors in explaining variation in WTP, as are changes in the duration of illness and the average income and age of the study populations. In addition, we test and reject the assumption of a constant WTP per QALY gain. We also demonstrate how the estimated meta-regression equations can serve as benefit transfer functions for policy analysis. By specifying the change in duration and severity of the acute illness and the characteristics of the affected population, we apply the regression functions to predict average WTP per case avoided. Copyright 2006 John Wiley & Sons, Ltd.

  2. Willingness to pay for improved respiratory and cardiovascular health: a multiple-format, stated-preference approach.

    Science.gov (United States)

    Johnson, F R; Banzhaf, M R; Desvousges, W H

    2000-06-01

    This study uses stated-preference (SP) analysis to measure willingness to pay (WTP) to reduce acute episodes of respiratory and cardiovascular ill health. The SP survey employs a modified version of the health state descriptions used in the Quality of Well Being (QWB) Index. The four health state attributes are symptom, episode duration, activity restrictions and cost. Preferences are elicited using two different SP formats: graded-pair and discrete-choice. The different formats cause subjects to focus on different evaluation strategies. Combining two elicitation formats yields more valid and robust estimates than using only one approach. Estimates of indirect utility function parameters are obtained using advanced panel econometrics for each format separately and jointly. Socio-economic differences in health preferences are modelled by allowing the marginal utility of money relative to health attributes to vary across respondents. Because the joint model captures the combined preference information provided by both elicitation formats, these model estimates are used to calculate WTP. The results demonstrate the feasibility of estimating meaningful WTP values for policy-relevant respiratory and cardiac symptoms, even from subjects who never have personally experienced these conditions. Furthermore, because WTP estimates are for individual components of health improvements, estimates can be aggregated in various ways depending upon policy needs. Thus, using generic health attributes facilitates transferring WTP estimates for benefit-cost analysis of a variety of potential health interventions. Copyright 2000 John Wiley & Sons, Ltd.

  3. Search for single production of vector-like quarks decaying into Wb in pp collisions at √(s) = 8 TeV with the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Aad, G. [CPPM, Aix-Marseille Univ. et CNRS/IN2P3, Marseille (France); Abbott, B. [Oklahoma Univ., Norman, OK (United States). Homer L. Dodge Dept. of Physics and Astronomy; Abdallah, J. [Academia Sinica, Taipei (China). Inst. of Physics; Collaboration: ATLAS Collaboration; and others

    2016-08-15

    A search for singly produced vector-like Q quarks, where Q can be either a T quark with charge +2/3 or a Y quark with charge -4/3, is performed in proton-proton collisions recorded with the ATLAS detector at the LHC. The dataset corresponds to an integrated luminosity of 20.3 fb{sup -1} and was produced with a centre-of-mass energy of √(s) = 8 TeV. This analysis targets Q → Wb decays where the W boson decays leptonically. A veto on massive largeradius jets is used to reject the dominant t anti t background. The reconstructed Q-candidate mass, ranging from 0.4 to 1.2 TeV, is used in the search to discriminate signal from background processes. No significant deviation from the Standard Model expectation is observed, and limits are set on the Q → Wb cross-section times branching ratio. The results are also interpreted as limits on the QWb coupling and the mixing with the Standard Model sector for a singlet T quark or a Y quark from a doublet. T quarks with masses below 0.95 TeV are excluded at 95 % confidence level, assuming a unit coupling and a BR(T → Wb) = 0.5, whereas the expected limit is 1.10 TeV. (orig.)

  4. Health-related quality of life in persons with apparent treatment-resistant hypertension on at least four antihypertensives.

    Science.gov (United States)

    Carris, N W; Ghushchyan, V; Libby, A M; Smith, S M

    2016-03-01

    Little is known about the impact of treatment-resistant hypertension (TRH) on health-related quality of life (HrQoL). We aimed to compare HrQoL measures in adults with apparent TRH (aTRH) and non-resistant hypertension among nationally representative US Medical Expenditure Panel Survey data pooled from 2000 to 2011. Cohorts compared were adults with aTRH (⩾2 unique fills from ⩾4 antihypertensive classes during a year) versus non-resistant hypertension (those with hypertension not meeting the aTRH definition). Key outcomes were cohort differences in SF-12v2 physical component summary (PCS) and mental component summary (MCS) scores and disease-state utility using the SF-6D. Of 57 150 adults with hypertension, 2501 (4.4%) met criteria for aTRH. Persons with aTRH, compared with non-resistant hypertension, were older (mean, 68 vs 61 years), had a higher BMI (30.9 vs 29.7 kg m(-)(2)) and were more likely to be Black (20% vs 14%), but less likely to be female (46% vs 54%). Persons with aTRH, compared with non-resistant hypertension, had lower mean PCS scores (35.8 vs 43.2; Phypertension. In conclusion, aTRH was associated with substantially lower HrQoL in physical functioning and health utility, but not in mental functioning, compared with non-resistant hypertension. The multivariable-adjusted reduction in physical functioning was similar in magnitude to previous observations comparing hypertension with no hypertension.

  5. Does ancestry influence health-related quality of life in type 1 diabetes patients? A nationwide study in Brazil.

    Science.gov (United States)

    Santos, Deborah Conte; Pizarro, Marcela Haas; Barros, Bianca S V; de Melo, Laura G Nunes; Porto, Luis Cristovão; Silva, Dayse A; Gomes, Marilia Brito

    2018-04-01

    The aim of the present study was to evaluate the relationship between self-reported color/race and genomic ancestry with HRQoL of patients with type 1 diabetes in a highly admixed population. This was a nationwide, cross-sectional study conducted with 1760 patients with type 1 diabetes from 2011 to 2014 at public clinics in all five Brazilian geographical regions. Information on HRQoL was obtained from two self-completed questionnaires: Short Form-6 Dimensions (SF-6D) and EuroQol-5 Dimensions (EQ-5D) with a visual analogue scale (EQ-VAS). Genomic ancestry was assessed using a Multiplex PCR methodology. Utility scores generated from the questionnaires were analyzed with multivariate logistic regression models. We included 1698 patients. Those patients who self-reported as black had lower EQ-VAS scores compared to the patients who self-reported as white (67.46 ± 18.45; 72.37 ± 16.44, respectively, p = 0.02). In a linear regression model, each 1% increase in African ancestry resulted in a 9.5 point decrease in EQ-VAS score (p ancestry remained associated with lower EQ-VAS scores. A higher level of African ancestry implicates on lower quality of life even after adjustments for sociodemographic and diabetes-related data. Gender, physical activity and diabetes-related microvascular complications were strongly associated with low HRQoL in all three questionnaires used. This fact highlights the importance of social aspects when assessing quality of life, as well as the need for regular practice of physical activity and prevention of chronic complications to improve patients' quality of life.

  6. Health-related quality of life, work productivity, and indirect costs among patients with irritable bowel syndrome with diarrhea.

    Science.gov (United States)

    Buono, Jessica L; Carson, Robyn T; Flores, Natalia M

    2017-02-14

    Irritable bowel syndrome (IBS) affects 10-15% of adults in the US, and is associated with significant impairment in health-related quality of life (HRQoL); however, information specific to the diarrhea subtype (IBS-D) is lacking. We assessed the impact of IBS-D on HRQoL, work productivity, and daily activities, and the associated indirect costs, among a sample of the US population. Respondents (≥18 years) from the 2012 US National Health and Wellness Survey who reported an IBS-D diagnosis by a physician or symptoms consistent with Rome II criteria for IBS-D were identified as having IBS-D. Controls included respondents without IBS-D or inflammatory bowel disease. HRQoL was assessed via the Short Form 36 Health Survey version 2 questionnaire and summarized into Mental and Physical Component Summary (MCS; PCS) scores and a Short Form-6 dimension (SF-6D) utility score. Work and activity impairment were assessed via the Work Productivity and Activity Impairment Questionnaire: General Health version (WPAI:GH), which measures absenteeism, presenteeism, overall work productivity loss, and daily activity impairment. Indirect costs were calculated using unit cost data from the Bureau of Labor Statistics and variables from the WPAI:GH. Generalized linear models were used to examine differences in health outcomes between respondents with IBS-D and controls, controlling for demographic and health characteristics. In total, 66,491 respondents (1102 IBS-D; 65,389 controls) were analyzed. Mean age was 48.7 years; 50% were female. Compared with controls, the IBS-D cohort reported significantly lower HRQoL (mean MCS: 45.16 vs. 49.48; p work productivity loss (20.7% vs. 13.2%; p work and daily activities, and higher indirect costs, imposing a substantial burden on patients and employers. These findings suggest a significant unmet need exists for effective IBS-D treatments.

  7. Is dibotermin alfa a cost-effective substitute for autologous iliac crest bone graft in single level lumbar interbody spine fusion?

    Science.gov (United States)

    Svedbom, Axel; Paech, Daniel; Leonard, Catherine; Donnell, David; Song, Fujian; Boszcyk, Bronek; Rothenfluh, Dominique A; Lloyd, Andrew; Borgman, Benny

    2015-11-01

    To evaluate the cost-effectiveness of dibotermin alfa compared with autologous iliac crest bone graft (ICBG) for patients undergoing single level lumbar interbody spinal fusion in a UK hospital setting. An individual patient data (IPD) meta-analysis of six randomized controlled clinical trials and two single arm trials compared dibotermin alfa on an absorbable collagen implantation matrix (ACIM) (n = 456) and ICBG (n = 244) on resource use, re-operation rates, and SF-6D (Short form 6-dimension) health utility (total N = 700). Failure-related second surgery, operating time, post-operative hospital stay, and quality-adjusted life years (QALYs) derived from the IPD meta-analysis were included as inputs in an economic evaluation undertaken to assess the cost-effectiveness of dibotermin alfa/ACIM versus ICBG for patients undergoing single level lumbar interbody spinal fusion. A four year time horizon and the United Kingdom (UK) National Health Service (NHS) and Personal Social Services (PSS) perspective was adopted in the base case, with sensitivity analyses performed to gauge parameter uncertainty. In the base case analysis, patients treated using dibotermin alfa/ACIM (12 mg pack) accrued 0.055 incremental QALYs at an incremental cost of £ 737, compared with patients treated with ICBG. This resulted in an incremental cost-effectiveness ratio (ICER) of £ 13,523, indicating that at a willingness-to-pay threshold of £ 20,000, dibotermin alfa/ACIM is a cost-effective intervention relative to ICBG from the NHS and PSS perspective. In a UK hospital setting, dibotermin alfa/ACIM is a cost-effective substitute for ICBG for patients who require lumbar interbody arthrodesis.

  8. Cost utility analysis of reduced intensity hematopoietic stem cell transplantation in adolescence and young adult with severe thalassemia compared to hypertransfusion and iron chelation program.

    Science.gov (United States)

    Sruamsiri, Rosarin; Chaiyakunapruk, Nathorn; Pakakasama, Samart; Sirireung, Somtawin; Sripaiboonkij, Nintita; Bunworasate, Udomsak; Hongeng, Suradej

    2013-02-05

    Hematopoieticic stem cell transplantation is the only therapeutic option that can cure thalassemia disease. Reduced intensity hematopoietic stem cell transplantation (RI-HSCT) has demonstrated a high cure rate with minimal complications compared to other options. Because RI-HSCT is very costly, economic justification for its value is needed. This study aimed to estimate the cost-utility of RI-HSCT compared with blood transfusions combined with iron chelating therapy (BT-ICT) for adolescent and young adult with severe thalassemia in Thailand. A Markov model was used to estimate the relevant costs and health outcomes over the patients' lifetimes using a societal perspective. All future costs and outcomes were discounted at a rate of 3% per annum. The efficacy of RI-HSCT was based a clinical trial including a total of 18 thalassemia patients. Utility values were derived directly from all patients using EQ-5D and SF-6D. Primary outcomes of interest were lifetime costs, quality adjusted life-years (QALYs) gained, and the incremental cost-effectiveness ratio (ICER) in US ($) per QALY gained. One-way and probabilistic sensitivity analyses (PSA) were conducted to investigate the effect of parameter uncertainty. In base case analysis, the RI-HSCT group had a better clinical outcomes and higher lifetime costs. The incremental cost per QALY gained was US $3,236 per QALY. The acceptability curve showed that the probability of RI-HSCT being cost-effective was 71% at the willingness to pay of 1 time of Thai Gross domestic product per capita (GDP per capita), approximately US $4,210 per QALY gained. The most sensitive parameter was utility of severe thalassemia patients without cardiac complication patients. At a societal willingness to pay of 1 GDP per capita, RI-HSCT was a cost-effective treatment for adolescent and young adult with severe thalassemia in Thailand compared to BT-ICT.

  9. Cost utility analysis of reduced intensity hematopoietic stem cell transplantation in adolescence and young adult with severe thalassemia compared to hypertransfusion and iron chelation program

    Directory of Open Access Journals (Sweden)

    Sruamsiri Rosarin

    2013-02-01

    Full Text Available Abstract Background Hematopoieticic stem cell transplantation is the only therapeutic option that can cure thalassemia disease. Reduced intensity hematopoietic stem cell transplantation (RI-HSCT has demonstrated a high cure rate with minimal complications compared to other options. Because RI-HSCT is very costly, economic justification for its value is needed. This study aimed to estimate the cost-utility of RI-HSCT compared with blood transfusions combined with iron chelating therapy (BT-ICT for adolescent and young adult with severe thalassemia in Thailand. Methods A Markov model was used to estimate the relevant costs and health outcomes over the patients’ lifetimes using a societal perspective. All future costs and outcomes were discounted at a rate of 3% per annum. The efficacy of RI-HSCT was based a clinical trial including a total of 18 thalassemia patients. Utility values were derived directly from all patients using EQ-5D and SF-6D. Primary outcomes of interest were lifetime costs, quality adjusted life-years (QALYs gained, and the incremental cost-effectiveness ratio (ICER in US ($ per QALY gained. One-way and probabilistic sensitivity analyses (PSA were conducted to investigate the effect of parameter uncertainty. Results In base case analysis, the RI-HSCT group had a better clinical outcomes and higher lifetime costs. The incremental cost per QALY gained was US $ 3,236 per QALY. The acceptability curve showed that the probability of RI-HSCT being cost-effective was 71% at the willingness to pay of 1 time of Thai Gross domestic product per capita (GDP per capita, approximately US $ 4,210 per QALY gained. The most sensitive parameter was utility of severe thalassemia patients without cardiac complication patients. Conclusion At a societal willingness to pay of 1 GDP per capita, RI-HSCT was a cost-effective treatment for adolescent and young adult with severe thalassemia in Thailand compared to BT-ICT.

  10. Quality of life instruments for economic evaluations in health and social care for older people: a systematic review.

    Science.gov (United States)

    Makai, Peter; Brouwer, Werner B F; Koopmanschap, Marc A; Stolk, Elly A; Nieboer, Anna P

    2014-02-01

    Gaining health may not be the main goal of healthcare services aimed at older people, which may (also) seek to improve wellbeing. This emphasizes the need of finding appropriate outcome measures for economic evaluation of such services, particularly in long-term care, capturing more than only health-related quality of life (HrQol). This review assesses the usefulness of HrQol and wellbeing instruments for economic evaluations specifically aimed at older people, focusing on generic and preference-based questionnaires measuring wellbeing in particular. We systematically searched six databases and extracted instruments used to assess HrQol and wellbeing outcomes. Instruments were compared based on their usefulness for economic evaluation of services aimed at older people (dimensions measured, availability of utility scores, extent of validation). We identified 487 articles using 34 generic instruments: 22 wellbeing (two of which were preference-based) and 11 HrQol instruments. While standard HrQol instruments measure physical, social and psychological dimensions, wellbeing instruments contain additional dimensions such as purpose in life and achievement, security, and freedom. We found four promising wellbeing instruments for inclusion in economic evaluation: Ferrans and Powers QLI and the WHO-Qol OLD, ICECAP-O and the ASCOT. Ferrans and Powers QLI and the WHO-Qol OLD are widely validated but lack preference-weights while for ICECAP-O and the ASCOT preference-weights are available, but are less widely validated. Until preference-weights are available for the first two instruments, the ICECAP-O and the ASCOT currently appear to be the most useful instruments for economic evaluations in services aimed at older people. Their limitations are that (1) health dimensions may be captured only partially and (2) the instruments require further validation. Therefore, we currently recommend using the ICECAP-O or the ASCOT alongside the EQ-5D or SF-6D when evaluating interventions

  11. Cost-utility of a specific collaborative group intervention for patients with functional somatic syndromes.

    Science.gov (United States)

    Konnopka, Alexander; König, Hans-Helmut; Kaufmann, Claudia; Egger, Nina; Wild, Beate; Szecsenyi, Joachim; Herzog, Wolfgang; Schellberg, Dieter; Schaefert, Rainer

    2016-11-01

    Collaborative group intervention (CGI) in patients with functional somatic syndromes (FSS) has been shown to improve mental quality of life. To analyse incremental cost-utility of CGI compared to enhanced medical care in patients with FSS. An economic evaluation alongside a cluster-randomised controlled trial was performed. 35 general practitioners (GPs) recruited 300 FSS patients. Patients in the CGI arm were offered 10 group sessions within 3months and 2 booster sessions 6 and 12months after baseline. Costs were assessed via questionnaire. Quality adjusted life years (QALYs) were calculated using the SF-6D index, derived from the 36-item short-form health survey (SF-36). We calculated patients' net-monetary-benefit (NMB), estimated the treatment effect via regression, and generated cost-effectiveness acceptability curves. Using intention-to-treat analysis, total costs during the 12-month study period were 5777EUR in the intervention, and 6858EUR in the control group. Controlling for possible confounders, we found a small, but significant positive intervention effect on QALYs (+0.017; p=0.019) and an insignificant cost saving resulting from a cost-increase in the control group (-10.5%; p=0.278). NMB regression showed that the probability of CGI to be cost-effective was 69% for a willingness to pay (WTP) of 0EUR/QALY, increased to 92% for a WTP of 50,000EUR/QALY and reached the level of 95% at a WTP of 70,375EUR/QALY. Subgroup analyses yielded that CGI was only cost-effective in severe somatic symptom severity (PHQ-15≥15). CGI has a high probability to be a cost-effective treatment for FSS, in particular for patients with severe somatic symptom severity. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Investing in health: is social housing value for money? A cost-utility analysis.

    Science.gov (United States)

    Lawson, K D; Kearns, A; Petticrew, M; Fenwick, E A L

    2013-10-01

    There is a healthy public policy agenda investigating the health impacts of improving living conditions. However, there are few economic evaluations, to date, assessing value for money. We conducted the first cost-effectiveness analysis of a nationwide intervention transferring social and private tenants to new-build social housing, in Scotland. A quasi-experimental prospective study was undertaken involving 205 intervention households and 246 comparison households, over 2 years. A cost-utility analysis assessed the average cost per change in health utility (a single score summarising overall health-related quality of life), generated via the SF-6D algorithm. Construction costs for new builds were included. Analysis was conducted for all households, and by family, adult and elderly households; with estimates adjusted for baseline confounders. Outcomes were annuitised and discounted at 3.5%. The average discounted cost was £18, 708 per household, at a national programme cost of £ 28.4 million. The average change in health utility scores in the intervention group attributable to the intervention were +0.001 for all households, +0.001 for family households, -0.04 for adult households and -0.03 for elderly households. All estimates were statistically insignificant. At face value, the interventions were not value for money in health terms. However, because the policy rationale was the amenity provision of housing for disadvantaged groups, impacts extend beyond health and may be fully realised over the long term. Before making general value-for-money inferences, economic evaluation should attempt to estimate the full social value of interventions, model long-term impacts and explicitly incorporate equity considerations.

  13. Pharmacoeconomic Analysis of Pain Medications Used to Treat Adult Patients with Chronic Back Pain in the United States.

    Science.gov (United States)

    Shah, Drishti; Anupindi, Vamshi Ruthwik; Vaidya, Varun

    2016-12-01

    Chronic back pain is an extremely common health problem. The largest category for pain therapy costs includes nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids. However, there has been limited evidence outlining their effectiveness in terms of quality of life for the treatment of chronic back pain. The authors performed a comparative pharmacoeconomic analysis of chronic back pain patients using NSAIDs versus those using opioids alone or combination opioid analgesics. This pharmacoeconomic evaluation was conducted using the Medical Expenditure Panel Survey (MEPS). Adults ≥18 years with chronic back pain diagnosis were included in the study. Individuals using opioids were matched in 1:1 ratio with those using only NSAIDs using propensity scores. All direct medical costs were included, and utility scores from Short Form 6D (SF-6D) were used to calculate QALYs (quality-adjusted life years). Monte Carlo probabilistic simulation technique was employed to determine the cost-effectiveness acceptability curve. After matching, there were 1109 patients in each cohort. The total mean annual cost was found to be $6137.41 for NSAIDs and $8982.28 for opioids. The mean utility gain for NSAIDs was found to be 0.661, whereas for opioids it was 0.633. Probabilistic sensitivity analysis showed that at all willingness-to-pay thresholds, the probability of NSAIDs being cost-effective was higher than the probability of the opioids being cost-effective. The authors found NSAIDs to be a dominant strategy as compared with opioids. Considering the higher cost associated with opioids/combination opioid analgesics, it might be cost-effective if they are used in patients who did not respond to the NSAIDs.

  14. Intégration de données temps-réel issues de capteurs dans un entrepôt de données géo-décisionnel

    OpenAIRE

    Mathieu, Jean

    2011-01-01

    Nous avons pu, au cours des dernières années, assister à une augmentation du nombre de capteurs utilisés pour mesurer des phénomènes de plus en plus variés. En effet, nous pouvons aujourd'hui utiliser les capteurs pour mesurer un niveau d'eau, une position (GPS), une température et même le rythme cardiaque d'un individu. La grande diversité de capteurs fait d'eux aujourd'hui des outils par excellence en matière d'acquisition de données. En parallèle à cette effervescence, les outils d'analyse...

  15. Sodobni islamski preporod na Kitajskem: stari vzorci, novi trendi

    Directory of Open Access Journals (Sweden)

    Maja Veselič

    2010-12-01

    Full Text Available This article examines some of the most salient phenomena marking contemporary Islamic revival among the Hui, a Chinese ethno-religious minority, such as reforms of religious instruction, a growing Hui presence in the international centres of Islamic learning, a flourishing religious publishing and a continous increase in the numbers of pilgrims to Mecca. These developments are placed in the context of historical development of Islam in China, from the advent of first Muslims in the 7th century up until today. The author argues that the present-day revival should largely be seen as a continuation of the Islamic reformist efforts of the Republican era, which were concurrent with the projects of Chinese modernization and nation-building, but were sharply interrupted by the various political campaigns of the first few decades of the People's Republic of China.

  16. The genus Scaphidium Olivier in East China (Coleoptera, Staphylinidae, Scaphidiinae

    Directory of Open Access Journals (Sweden)

    Liang Tang

    2014-04-01

    Full Text Available A review of 21 species of Scaphidium Olivier from East China is presented, including 6 new species: S. jinmingi sp. n. (Zhejiang, Anhui, Chongqing, S. crypticum sp. n.(Zhejiang, Fujian, Jiangxi, Guangxi, S. varifasciatum sp. n. (Zhejiang, An’hui, S. robustum sp. n. (Fujian, Guizhou, Chongqing, Guangxi, Yunnan, S. connexum sp. n. (Zhejiang, Fujian, Guangxi, and S. bayibini sp. n. (An’hui. New province records for S. comes Löbl, S. grande Gestro, S. sauteri Miwa & Mitono, S. formosanum Pic, S. carinense Achard, S. sinense Pic, S. delatouchei Achard, S. biwenxuani He, Tang & Li, S. klapperichi Pic, S. stigmatinotum Löbl, S. wuyongxiangi He, Tang & Li, and S. direptum Tang & Li as well as some biological notes are reported. Habitus and diagnostic characters of all species are photographed and a key to Scaphidium species of East China is provided.

  17. Joaquín Sorolla pintor del Rey Alfonso XIII 

    Directory of Open Access Journals (Sweden)

    Jordane Fauvey

    2011-06-01

    Full Text Available « Aujourd’hui Sorolla intéresse », déclarait Florencio de Santa-Ana, directeur du Musée Sorolla de Madrid, à l’occasion de l’exposition Sorolla íntimo (2004. En effet, depuis les années 1980-90, le peintre des plages de Valence est à la mode. En témoignent la fréquence des expositions concernant directement son œuvre, ou encore le prix des toiles qui sont aujourd’hui les plus élevées du marché, juste derrière les chef-d’œuvres des impressionnistes français. Ces dernières années ont également...

  18. Introduction

    Directory of Open Access Journals (Sweden)

    Hamit Bozarslan

    2011-11-01

    Full Text Available Peut-on parler de l’Irak avec la distance critique consistant à taire sa colère de citoyen par rapport à l’horreur d’aujourd’hui et celle d’hier ? Celle d’aujourd’hui, car comment ne pas constater qu’à un embargo de plus de dix ans et à une occupation autant arrogante qu’imprudente fait désormais suite une violence multiforme détruisant la société irakienne dans ses fondements mêmes ? Et celle d’hier, car comment ne pas se souvenir que le régime renversé laissa derrière lui un pays dévasté pa...

  19. Market for domotics in the Netherlands. Major or minor?; Nederlandse domoticamarkt. In majeur of mineur?

    Energy Technology Data Exchange (ETDEWEB)

    Uythof, B. [Invenit, Domotica Platform Nederland, Amsterdam (Netherlands)

    2003-10-01

    A brief overview is given of new developments in the market for automation systems for houses (domotics), in particular the option to make use of broadband technology. [Dutch] De klassieke domoticasystemen, waarbij via bussystemen zaken als verwarming, verlichting en veiligheid worden geregeld, staan onder druk door wensen van consumenten. Zij willen af van het grote aantal netwerkjes met bijbehorende bedrading in huis. Ook zoekt deze groep naar een verdergaande integratie van diensten en producten in zijn woning. Uit buitenlands onderzoek blijkt dat deze consumenten al een bepaald voorzieningsniveau op internetgebied, zoals breedband, in huis hebben. De huidige breedbandtechniek maakt het mogelijk via een bussysteem, of zelfs draadloos, apparaten te bedienen en mee te communiceren. Toepassingen waar veel van wordt verwacht. Het is daarom zaak voor de 'klassieke' domotica om allianties aan te gaan met de moderne vormen van domotica- en breedbandontwikkelingen.

  20. Critique in action. To fight, to play, to break

    OpenAIRE

    Frère, Bruno

    2011-01-01

    Le communisme n'est plus, les grands mouvements critiques des années 70 auraient fait long feux et il n'y aurait plus d'espace aujourd'hui que pour l'adaptation au monde tel qu'il est. Les désaffiliés doivent être réinsérés, les migrants assimilés, les jeunes adaptés, les moins jeunes reformés. L'enjeu pour tout un chacun serait aujourd'hui d'augmenter son employabilité, d'assurer sa flexibilité et sa mobilité afin de s'assurer sinon un avenir, en tout cas un statuquo dans une société trans...

  1. Les chemins du savoir

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cathy Egan

    solutions africaines aux problèmes causés par les politiques d'ajustement structurel sévères imposées par les institutions financières internationales. Aujourd'hui, cet organisme à but non lucratif, se place au premier rang des organismes de recherche en économie en. « Quand la démocratie bat de l'aile dans un pays, tout.

  2. China’s Muslims: Separatism and Prospects for Ethnic Peace

    Science.gov (United States)

    2006-09-01

    white caps, halal food , and religious practices in order to maintain a successful combination of Chinese and Islamic life. Though Lipman would argue...expatriate communities. Instead, they have largely conformed to overseas Chinese communities with only a few identifying characteristics (such as halal ...standards of living.141 Under the new free market reforms, Hui living in Na Homestead operate 70 percent of the restaurants, food stands, and private

  3. Suivi de la femme enceinte seropositive au VIH a l'Hopital de be a ...

    African Journals Online (AJOL)

    Introduction: La situation épidémiologique du VIH/Sida est aujourd'hui très préoccupante dans tous les continents. Les efforts pour endiguer cette pandémie se font à travers un certain nombre de stratégies spécifiques dont la prévention de la transmission du VIH de la mère à l'enfant (PTME). Objectif: Analyser le suivi des ...

  4. Levitikus as agtergrond van Markus 5:25–34, geïnterpreteer in terme ...

    African Journals Online (AJOL)

    2 Feb 2011 ... is nie onrein nie, want dit is normaal dat daar mis sal wees daar waar koeie beweeg; dit is dus in plek. Wanneer hierdie ... mis voor in die huis, 'n plek voor waar dit nie hoort nie en dan is dit onrein. Onreinheid verwys ..... die shalom kan ervaar wat haar so lank ontneem was. kai. i;sqi u`gih.j avpo. th/j ma ...

  5. Sexospécificités | Page 215 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    alimentation et l'agriculture (FAO) estime que, sur près de 250 000 variétés végétales propres à la culture, on n'en cultive aujourd'hui qu'environ 7 000, soit moins de 3 %. Le non-usage mène à l'abandon et, éventuellement, à l'extinction. Read more ...

  6. Mangghuer Embroidery: A Vanishing Tradition

    OpenAIRE

    Aila Pullinen

    2015-01-01

    Aila Pullinen. 2015. Mangghuer Embroidery: A Vanishing Tradition IN Gerald Roche and CK Stuart (eds) Asian Highlands Perspectives 36: Mapping the Monguor, 178-188, 301-332. Visits were undertaken in the years 2001 and 2002 to Minhe Hui and Mangghuer (Tu) Autonomous County, Haidong Municipality, Qinghai Province, China to research and document Mangghuer embroidery. This research is summarized in terms of the history of Mangghuer embroidery, tools and materials, embroidery techniques, embr...

  7. PATHOGENIE COMPAREE DE QUELQUES SOUCHES DE ...

    African Journals Online (AJOL)

    AISA

    . Deux types d'inoculum du champignon (talc et vermiculite) ... prendre conscience de l'importance des dégâts provoqués par cette maladie. Aujourd'hui, la fusariose du ... Le matériel végétal est constitué de 4 variétés d'espèces maraîchères :.

  8. China Debates the Future Security Environment

    Science.gov (United States)

    2000-01-01

    Bike, Zhot~uo da qushi (China megatrends )( Belling: Hualing chubanshe, 1996). For warnings on the need to conceal increasing national power, see Ma...became Japan’s prime minister in 1957. Troop 731, which had engaged in biological warfare experiments, was exempted from trial. In March 1950, all...gongye chubanshe, 1998. Lu Hui. He hua sheng wuqi de h’shi yu weilai CFhe history and future of nuclear, chemical, and biological weapons). Beijing

  9. Seks korraks kõik: 15. PÖFF sai läbi, "Eesti film 100" ootab ees

    Index Scriptorium Estoniae

    2011-01-01

    15. Pimedate Ööde Filmifestivali võitjatest. Parim Euraasia film "Lihtne elu" (režissöör Ann Hui, Hiina), parim režissöör Lynne Ramsay "Me peame Kevinist rääkima" (Suurbritannia), parim meeesnäitleja Sven Nordin filmist "Norra pojad", parim naisnäitleja Deanie Ip filmist "Lihne elu". Elutööauhinnad said Rein Raamat, Rein Maran, Fridrik Thor Fridriksson ja Aleksandr Sokurov

  10. Võistluskavade parimad said eile pärjatud / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2011-01-01

    15. Pimedate Ööde Filmifestivali võitjatest. Parim Euraasia film "Lihtne elu" (režissöör Ann Hui, Hiina), parim režissöör Lynne Ramsay ("Me peame Kevinist rääkima", Suurbritannia). Balti filmide konkursil parim Eesti film "Surnuaiavahi tütar", parim operaator Mart Taniel ("Idioot", Eesti). Auhindade võitjad loetletud

  11. CRDI - Centre de recherches pour le développement international |

    International Development Research Centre (IDRC) Digital Library (Canada)

    Lire leurs observations. Nos experts font part de leurs réflexions sur les questions et les approches sur lesquelles se penchent les acteurs du développement international aujourd'hui, ainsi que sur le rôle de la recherche dans la mise au point de solutions. Image. Homme travaillant à l'intérieur d'un grand tube d'acier ...

  12. Using Linear Equating to Map PROMIS(®) Global Health Items and the PROMIS-29 V2.0 Profile Measure to the Health Utilities Index Mark 3.

    Science.gov (United States)

    Hays, Ron D; Revicki, Dennis A; Feeny, David; Fayers, Peter; Spritzer, Karen L; Cella, David

    2016-10-01

    Preference-based health-related quality of life (HR-QOL) scores are useful as outcome measures in clinical studies, for monitoring the health of populations, and for estimating quality-adjusted life-years. This was a secondary analysis of data collected in an internet survey as part of the Patient-Reported Outcomes Measurement Information System (PROMIS(®)) project. To estimate Health Utilities Index Mark 3 (HUI-3) preference scores, we used the ten PROMIS(®) global health items, the PROMIS-29 V2.0 single pain intensity item and seven multi-item scales (physical functioning, fatigue, pain interference, depressive symptoms, anxiety, ability to participate in social roles and activities, sleep disturbance), and the PROMIS-29 V2.0 items. Linear regression analyses were used to identify significant predictors, followed by simple linear equating to avoid regression to the mean. The regression models explained 48 % (global health items), 61 % (PROMIS-29 V2.0 scales), and 64 % (PROMIS-29 V2.0 items) of the variance in the HUI-3 preference score. Linear equated scores were similar to observed scores, although differences tended to be larger for older study participants. HUI-3 preference scores can be estimated from the PROMIS(®) global health items or PROMIS-29 V2.0. The estimated HUI-3 scores from the PROMIS(®) health measures can be used for economic applications and as a measure of overall HR-QOL in research.

  13. Étude économique des foyers domestiques par la technique d ...

    African Journals Online (AJOL)

    Les foyers font partie de la vie courante. Chaque ménage en utilise pour la cuisson de ses repas. Dans les pays en développement, la plupart des populations utilisent surtout des foyers à combustibles ligneux. Les effets négatifs sur l'environnement sont aujourd'hui bien connus : poches de désertification, érosion des sols, ...

  14. Annotated Bibliography of Publications from the US Navy’s Marine Mammal Program, Update. Revision A.

    Science.gov (United States)

    1985-07-01

    radio tags, and freeze branding. Hui, C. A. 1979 Undersea topography and distribution of dolphins of the genus Delphinus in the Southern California...Delphinapterus leucas. Sleep Research 3:85 (Abstract). Observed behavior consisted of active waking, quiet waking, and stereotypic circular swimming. The...behavior consisted of periods of unambiguous waking, stereotypic circular swimming with brief (20-30 sec) eye closure and other indications of sleep

  15. China’s Forbearance Has Limits: Chinese Threat and Retaliation Signaling and Its Implications for a Sino-American Military Confrontation

    Science.gov (United States)

    2013-04-01

    operate businesses and live on the mainland; communications and travel are now easier; cross-strait tourism is growing; academic contacts are increasing...People’s Daily COMMENTATOR ARTICLE on upholding “one- China principle” Xinhua Commentator on Lee Teng- hui “ doomed to be pinned on the pole of...illegal act that went against the will of the people”; any effort toward Taiwan independence “is doomed to fail” Xinhua reports failure of CSB

  16. Résultats de recherche | Page 164 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Encore aujourd'hui, la tribu continue de jouer un rôle de premier plan dans les structures sociales au Moyen-Orient, en particulier au Yémen, en Iraq et en Jordanie. Il existe en effet un lien étroit entre le politique et l'organisation tribale. Projet. Cybergouvernement à Fès, au Maroc. Dans la phase pilote du projet (no ...

  17. Le socle d'une œuvre, invisible mais essentiel

    OpenAIRE

    Huguenin, Daniel

    2015-01-01

    Tiré du site internet du blog des Musées d'art et d'histoire (http://blog.mahgeneve.ch): "Le support se faisant aujourd'hui le plus discret possible, voire invisible. Sa réalisation nécessite une étroite collaboration entre les différents acteurs d'une exposition car le socleur doit allier les besoins de la conservation et de la muséographie.".

  18. 1336-IJBCS-Article-Amani Michel Kouassi

    African Journals Online (AJOL)

    KODJIO NORBERT

    travaux dont les plus récents sont ceux de. Soro (2002), Lasm et al. (2008), Oga et al. (2009), Soro (2010) .... Le graphe de corrélation de la conductivité électrique (CE) en fonction de la somme des concentrations .... l'estimation des caractéristiques des gisements miniers, la géostatistique est aujourd'hui appliquée à ...

  19. (FLE) dans un environnement des TIC

    African Journals Online (AJOL)

    enseignement du français langue étrangères se sont succédées, les unes en rupture avec les précédentes et les autres comme une adaptation aux nouveaux besoins de la société. Aujourd'hui la réalité des TIC dans le domaine de ...

  20. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 36; Issue 4. Investigation of localization effect in GaN-rich InGaN alloys and modified band-tail model. Chuan-Zhen Zhao Bin Liu De-Yi Fu Hui Chen Ming Li Xiang-Qian Xiu Zi-Li Xie Shu-Lin Gu You-Dou Zheng. Volume 36 Issue 4 August 2013 pp 619-622 ...

  1. TIBETAN WOMEN'S DAILY LIFE: FIRE, FUEL, WATER COLLECTION, COOKING, AND CHILDCARE

    Directory of Open Access Journals (Sweden)

    Rdo rje don 'grub རྡོ་རྗེ་དོན་འགྲུབ། Duojieduanzhi 多杰端智

    2018-05-01

    Full Text Available The daily lives of Lha mtsho skyid, Klu mo, and Tshe thar skyid, Tibetan women living in impoverished A bo rgyud (Awubuju Tibetan Village, Gser gzhung (Jinyuan Township, Dpal lung (Hualong Hui Autonomous County, Mtsho shar (Haidong City, Mtsho sngon (Qinghai Province in May 2011 are described. Aspects of fuel collection, family relationships, food preparation, child care, schooling, water collection, and day-to-day anxieties are described, illustrating the reality of their daily existence.

  2. Rôle politique des tribus : une analyse du tribalisme, de l'islamisme ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Encore aujourd'hui, la tribu continue de jouer un rôle de premier plan dans les structures sociales au Moyen-Orient, en particulier au Yémen, en Iraq et en Jordanie. Il existe en effet un lien étroit entre le politique et l'organisation tribale. Au Yémen, par exemple, la tribu pose tout un défi à l'État, et il semble même parfois lui ...

  3. From columbine to virgínia tech: empirical based reflections about an expanding phenomenon / De columbine à virgínia tech: reflexões com base empírica sobre um fenômeno em expansão

    OpenAIRE

    Leonardo Conceição Guimarães; Francisco Dyonísio Cardoso Mendes; Timoteo Madaleno Vieira

    2009-01-01

    School shooting phenomenon has attracted attention throughout the world, especially after the Columbine massacre in April, 1999. In that event, 12 people died and about 30 were hurt. Some years later, in April 2007, Cho Seung-Hui carried out an even more impressive deed, shooting and killing 32 people at Virginia Polytechnic Institute and State University, USA. This article presents school shooting as a growing phenomenon that may happen anywhere and not just in the United States. A reflectio...

  4. Les Céphalopodes déroulés et l’irréversibilité de l’évolution

    NARCIS (Netherlands)

    Dollo, Louis

    1922-01-01

    1. — Nous en sommes exactement, aujourd’hui, avec l’Irréversibilite au même point qu’avec la Loi de la Récapitulation: les uns l’affirment absolument; les autres la nient absolument; d’autres, enfin, l’admettent sous conditions à déterminer. D’aucuns s’en servent sans cesse, mais sans se douter

  5. Genève explore le centre de l'univers le CERN nourrit les espoirs des physiciens

    CERN Multimedia

    Koller, A

    2004-01-01

    "Si Albert Einstein vivait encore, il emménagerait sans doute à Genève ou en France voisine, au moins pour les quinze prochaines années. Moins pour célébrer dès aujourd'hui les 50 ans du CERN que pour travailler dès 2007 avec le Large hadron Collder (LHC)"(1/2 page)

  6. Prévalence, facteurs associés et prédisposant au syndrome ...

    African Journals Online (AJOL)

    Introduction: Le syndrome métabolique est associé aux maladies cardiovasculaires. L'infection au VIH est devenue aujourd'hui une maladie chronique. L'objectif de cette étude est de déterminer la prévalence, les facteurs associés et prédisposant au syndrome métabolique chez les patients infectés par le VIH sous ...

  7. 1302-IJBCS-Article-Mathieu Gueye

    African Journals Online (AJOL)

    KODJIO NORBERT

    La constipation est une pathologie bien connue de la médecine traditionnelle africaine. Pour la traiter, on utilise à la fois les ressources naturelles aujourd'hui fortement menacées et les savoirs traditionnels. La technique des entretiens ouverts semi-structurés a été partout utilisée. Nous avons interrogé entre 2008 et 2010.

  8. 506-IJBCS-Article-Ines Edna deleke KOKO

    African Journals Online (AJOL)

    User

    INTRODUCTION. Au Bénin, comme dans la plupart des pays d'Afrique ou en voie de développement, les populations se soignent avec les plantes médicinales. Encore aujourd'hui, plus de 80% de la population ouest-africaine dépend de la médecine traditionnelle en cas de maladie. (Akerele, 1991, 1993 ; Sofowora, 1996 ...

  9. Là où compte chaque goutte de pluie – la gestion des risques ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    10 nov. 2011 ... Je consulte chaque jour notre pluviomètre et je prends des notes, dit-elle. Autrefois, les prévisions de la météo, c'était pour beaucoup d'entre nous comme un tambour qu'on entendait au loin, mais aujourd'hui on comprend bien le message. Ça nous aide à prédire la quantité de pluie que nous allons ...

  10. Une force venant du futur chercherait à saboter l'expérience du LHC...

    CERN Multimedia

    Scappaticci, Bruno

    2009-01-01

    "A quelques jours de la reprise de l'expérience du LHC, on ne parle plus de la menace d'un trou noir, mais deux physicines souteinnent aujourd'hui une tout autres hypothèse: la nature, depuis le futur, va continuer de contrarier les travaux du Cern, afin d'éviter à l'Homme de mettre le doigt là où il ne faut pas..." (1.5 pages)

  11. La maîtrise des sciences de l'environnement au Moyen-Orient ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 janv. 2011 ... En outre, Peter Johnson, ancien professeur de géographie à l'Université Carleton, aujourd'hui retraité, a consulté plusieurs personnes qui connaissent bien et la Jordanie et le Canada afin de tracer les grandes lignes du programme de maîtrise destiné à l'Université du Yarmouk. Ouvrir les portes aux ...

  12. Favoriser l'entrepreneuriat | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    10 avr. 2014 ... Pour comprendre les entrepreneurs d'aujourd'hui, il suffit de s'en remettre au Global Entrepreneurship Monitor (GEM). Lancé en 1999, le projet GEM constitue la plus longue étude sur l'entrepreneuriat au monde; elle s'appuie sur les travaux de plus de 300 chercheurs dans 99 pays. Dans ses enquêtes ...

  13. COmmunications and Networking with QUantum operationally Secure Technology for Maritime Deployment (CONQUEST)

    Science.gov (United States)

    2016-12-02

    in Computer Science, 4392:456–478, February 2007. arXiv:quant-ph/0608199. [15] Renato Renner, Nicolas Gisin, and Barbara Kraus. Information-theoretic...Letters 18, 1896-1898 (1993). [2] R. Nair, S. Guha, and Si-Hui Tan , ”Realizable receivers for discriminating arbitrary coherent-state waveforms and multi-copy quantum states near the quantum limit”, Phys. Rev. A 89, 032318 (2014).

  14. Response to Bile Salts in Clinical Strains of Acinetobacter baumannii Lacking the AdeABC Efflux Pump: Virulence Associated with Quorum Sensing

    Directory of Open Access Journals (Sweden)

    Maria López

    2017-05-01

    Full Text Available Introduction:Acinetobacter baumannii is an opportunistic nosocomial pathogen associated with multiple infections. This pathogen usually colonizes (first stage of microbial infection host tissues that are in contact with the external environment. As one of the sites of entry in human hosts is the gastrointestinal tract, the pathogen must be capable of tolerating bile salts. However, studies analyzing the molecular characteristics involved in the response to bile salts in clinical strains of A. baumannii are scarce.Material and Methods: Microbiological and transcriptional studies (arrays and RT-PCR in the response to bile salts were carried out in isogenic (A. baumanni ΔadeB ATCC 17978 and A. baumannii ΔadeL ATCC 17978 and clinical strains from clone ST79/PFGE-HUI-1 which is characterized by lacking the AdeABC efflux pump and by overexpression the AdeFGH efflux pump.Results and Discussion: In presence of bile salts, in addition to the glutamate/aspartate transporter were found overexpressed in A. baumannii ΔadeB ATCC 17978, the virulence factors (surface motility, biofilm, and Type VI Secretion System which are associated with activation of the Quorum Sensing system. Overexpression of these factors was confirmed in clinical strains of clone ST79/PFGE-HUI-1.Conclusions: This the first study about the adaptive response to bile salts investigating the molecular and microbiological characteristics in response to bile salts of an isogenic model of A. baumannii ATCC 17978 and clinical isolates of A. baumannii (clinical strains of ST79/PFGE-HUI-1 lacking the main RND efflux pump (AdeABC. Clinical isolates of A. baumannii lacking the AdeABC efflux pump (clone ST79/PFGE-HUI-1 displayed a new clinical profile (increased invasiveness possibly associated with the response to stress conditions (such as the presence of bile salts.

  15. Response to Bile Salts in Clinical Strains of Acinetobacter baumannii Lacking the AdeABC Efflux Pump: Virulence Associated with Quorum Sensing.

    Science.gov (United States)

    López, Maria; Blasco, Lucia; Gato, Eva; Perez, Astrid; Fernández-Garcia, Laura; Martínez-Martinez, Luis; Fernández-Cuenca, Felipe; Rodríguez-Baño, Jesús; Pascual, Alvaro; Bou, German; Tomás, Maria

    2017-01-01

    Introduction: Acinetobacter baumannii is an opportunistic nosocomial pathogen associated with multiple infections. This pathogen usually colonizes (first stage of microbial infection) host tissues that are in contact with the external environment. As one of the sites of entry in human hosts is the gastrointestinal tract, the pathogen must be capable of tolerating bile salts. However, studies analyzing the molecular characteristics involved in the response to bile salts in clinical strains of A. baumannii are scarce. Material and Methods: Microbiological and transcriptional studies (arrays and RT-PCR) in the response to bile salts were carried out in isogenic ( A. baumanni Δ adeB ATCC 17978 and A. baumannii Δ adeL ATCC 17978) and clinical strains from clone ST79/PFGE-HUI-1 which is characterized by lacking the AdeABC efflux pump and by overexpression the AdeFGH efflux pump. Results and Discussion: In presence of bile salts, in addition to the glutamate/aspartate transporter were found overexpressed in A. baumannii Δ adeB ATCC 17978, the virulence factors (surface motility, biofilm, and Type VI Secretion System) which are associated with activation of the Quorum Sensing system. Overexpression of these factors was confirmed in clinical strains of clone ST79/PFGE-HUI-1. Conclusions: This the first study about the adaptive response to bile salts investigating the molecular and microbiological characteristics in response to bile salts of an isogenic model of A. baumannii ATCC 17978 and clinical isolates of A. baumannii (clinical strains of ST79/PFGE-HUI-1) lacking the main RND efflux pump (AdeABC). Clinical isolates of A. baumannii lacking the AdeABC efflux pump (clone ST79/PFGE-HUI-1) displayed a new clinical profile (increased invasiveness) possibly associated with the response to stress conditions (such as the presence of bile salts).

  16. Des rebuts lucratifs : la réduction et l'utilisation des prises accessoires

    International Development Research Centre (IDRC) Digital Library (Canada)

    28 oct. 2010 ... Aujourd'hui, grâce à des recherches appuyées par le CRDI, la capture involontaire de poissons a diminué et davantage de prises accessoires sont transformées pour la consommation humaine. Il y a peu de temps, partout dans le monde, les pêcheurs commerciaux rejetaient à l'eau bon nombre des ...

  17. 489-IJBCS-Article-Toussaient Lougbegnon

    African Journals Online (AJOL)

    User

    effet, ces espèces auraient intégré les habitudes alimentaires de ces populations lors de la sécheresse des années 80 où les terres des basses vallées seules offraient des conditions propices à ces espèces. Aujourd'hui, la consommation de ces espèces se fait sans souvenir des conditions qui l'ont engendré ; ce qui de ce ...

  18. Virtual surgical planning and 3D printing in prosthetic orbital reconstruction with percutaneous implants: a technical case report

    OpenAIRE

    Huang, Yu-Hui; Seelaus, Rosemary; Zhao, Linping; Patel, Pravin K; Cohen, Mimis

    2016-01-01

    Yu-Hui Huang,1,2 Rosemary Seelaus,1,2 Linping Zhao,1,2 Pravin K Patel,1,2 Mimis Cohen1,2 1The Craniofacial Center, Department of Surgery, Division of Plastic & Reconstructive Surgery, University of Illinois Hospital & Health Sciences System, 2University of Illinois College of Medicine at Chicago, Chicago, IL, USA Abstract: Osseointegrated titanium implants to the cranial skeleton for retention of facial prostheses have proven to be a reliable replacement for adhesive systems. ...

  19. IDRC starts new work in ASEAN | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    4 août 2016 ... Transformer les chaînes de valeur en avantages sociaux en Asie du SudEst. Les chaînes de valeur mondiales, qui constituent aujourd'hui la plus importante part du commerce mondial, se composent de producteurs et d'entreprises qui créent des biens comme entrants destinés à.

  20. Comment les travaux de recherche subventionnés par le CRDI ont ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    25 oct. 2010 ... Une vision planétaire pour les petites entreprises d'Égypte. Autrefois ignorées et sous-évaluées, les petites entreprises sont aujourd'hui à l'avant-plan des préoccupations alors que l'Égypte prend des mesure. Voir davantageUne vision planétaire pour les petites entreprises d'Égypte ...

  1. Résultats de recherche | Page 438 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les pays en développement accusent encore aujourd'hui beaucoup de retard par rapport aux pays développés concernant l'usage généralisé des technologies de l'information, et en particulier la mise en place de systèmes de gouvernement électronique (. Publication Date. 29 avril 2014. Livres.

  2. Résultats de recherche | Page 66 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Parvenir à une réelle égalité entre les sexes en ce qui concerne la santé des adolescents. Le monde n'a jamais compté autant de jeunes (de 10 à 24 ans) ayant atteint l'âge de la reproduction qu'aujourd'hui. Perspectives. Environment CLIMATE CHANGE ADAPTATION Climate change Civil society ...

  3. Résultats de recherche | Page 441 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les pays en développement accusent encore aujourd'hui beaucoup de retard par rapport aux pays développés concernant l'usage généralisé des technologies de l'information, et en particulier la mise en place de systèmes de gouvernement électronique (. Publication Date. 29 avril 2014. Livres.

  4. Entretien avec Shafika Isaacs sur la transformation de l'éducation en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    4 févr. 2011 ... Aujourd'hui, beaucoup de gouvernements parlent de stratégies macroéconomiques ainsi que de stratégies de l'éducation et du perfectionnement des ressources humaines. Nous pensons qu'il faut tenir compte, dans l'élaboration de ces stratégies, du rôle que peuvent jouer les TIC dans l'amélioration de ...

  5. The construct validity of the health utilities index mark 3 in assessing health status in lung transplantation

    Directory of Open Access Journals (Sweden)

    Zuk Dalyce

    2010-09-01

    Full Text Available Abstract Purpose To assess the cross-sectional construct validity of the Health Utilities Index Mark 3 (HUI3 in lung transplantation. Methods Two hundred and thirteen patients (103 pre-transplant and 110 post-transplant with mean age 53 years old (SD 13 were recruited during a randomized controlled clinical trial at the out-patient clinic in a tertiary institution. At baseline, patients self-completed measures that included the HUI3, EuroQol EQ-5D, Hospital Anxiety and Depression Scale (HADS and socio-demographic questionnaire. Six-minute walk test scores and forced expiratory volume in 1 second data were collected from patient's medical records. A priori hypotheses were formulated by members of the transplant team about the expected degree of association between the measures. Correlation coefficients of Results Of the ninety predictions made, forty three were correct but in 31 the correlation was slightly lower than predicted and in 7 the correlations were much higher than predicted. In 48% of the cases, predicted and observed associations were in agreement. Predictions of associations were off by one category in 42% of the cases; in 10% of the cases the predictions were off by two categories. Conclusions This is the first study providing evidence of cross-sectional construct validity of HUI3 in lung transplantation. Results indicate that the HUI3 was able to capture the burden of lung disease before transplantation and that post-transplant patients enjoyed higher health-related quality of life than pre-transplant patients.

  6. Nouvelles de l'Italie sur la linguistique et l'education

    Directory of Open Access Journals (Sweden)

    Raffaele Simone

    1984-12-01

    Full Text Available L'auteur donne. des informations sur l'état actuel des débats concernant le développement du langage dans l'école italienne d'aujourd'hui, et prop6se U:ne "nouvelle" notion de linguistique appliquée, considérée en tant que confrontation de systèmes de sens, plutôt de systèmes de formes.

  7. 雲南回族における呪術的治療行為について― 呪術とモダニティ論を用いた整理

    OpenAIRE

    木村, 自

    2008-01-01

    This paper tries to clarify the field data concerning the healing practices of Hui or Chinese Muslims in a rural village in Yunnan province. Two points are significant for analyzing healing practices in the study of anthropology: first, interface between traditional healings and the modernization both of medicine and religion, and second, embracement of the otherness in the narratives of healings. Traditional healings have been marginalized from those two modernist discourses. In response to ...

  8. Managing Small-Scale Fisheries : Alternative Directions and Methods

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'humanité est de plus en plus tributaire des ressources marines et côtières. Les petites entreprises de pêche emploient aujourd'hui 50 des 51 millions de pêcheurs du monde, qui se trouvent pratiquement tous dans des pays en développement. Ensemble, ils produisent plus de la moitié des prises annuelles mondiales de ...

  9. UIE [)OO() VA~ GE~ER,L\\AL [)E LA

    African Journals Online (AJOL)

    op die leiding van hulle offisiere moes ver- trou, wat ook al mag gebeur. 48. Dit is beweer dat De la Rey, wat bewus was van Kemp se houding in verband met die aanval op Suidwes-Afrika, die woorde gebe- sig het omdat hy geweet het dat Kemp die kamp tot rebellie sou oproep.'o. De la Rey het die nag by Kemp aan huis.

  10. un_focus - Les semences du monde : L'amélioration participative ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sur près de 250 000 variétés végétales propres à la culture, on n'en cultive aujourd'hui qu'environ 7 000, soit moins de 3 %. ... fondamentales, de la conception des projets in situ aux droits des agriculteurs et des phytogénéticiens, et fait valoir l'importance de nouvelles lois et politiques à l'appui des objectifs énoncés.

  11. A facile method to prepare superparamagnetic iron oxide and hydrophobic drug-encapsulated biodegradable polyurethane nanoparticles

    OpenAIRE

    Cheng,Kuo-Wei; Hsu,Shan-hui

    2017-01-01

    Kuo-Wei Cheng, Shan-hui Hsu Institute of Polymer Science and Engineering, College of Engineering, National Taiwan University, Taipei, Taiwan, Republic of China Abstract: Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging, targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encaps...

  12. Paludisme et Agriculture au Kenya

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nancy Minogue

    Justus Mwangi n'ira pas travailler à la rizière aujourd'hui. Dans le miroitement du chaud soleil de midi, il reste plutôt à l'ombre d'un arbre à discuter du plus grave problème de santé qui frappe son village : le paludisme. « C'est une maladie handicapante parce qu'elle nous empêche de marcher. Elle provoque des maux de.

  13. Économie | Page 23 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Colour. #2C81B5. Le G8 (Allemagne, Angleterre, Canada, États-Unis, France, Italie, Japon, Russie et Union européenne) est aujourd'hui le principal vecteur politique de la mondialisation. Il est également la force politique qui soutient le plus fermement les institutions multilatérales façonnant la gouvernance économique ...

  14. ÉTUDE DE CAS – Côte d'Ivoire : De la forêt aux champs en Côte d ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 janv. 2011 ... Aujourd'hui, Buyo fait partie de la « nouvelle ceinture du café et du cacao » de la Côte d'Ivoire et est devenu un pôle d'attraction pour les immigrants. La plupart y viennent en quête de terres où s'adonner aux cultures marchandes. Certains trouvent du travail dans lesexploitations forestières ou dans les ...

  15. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    pp 85-91 Research Article. Cloning and study of adult-tissue-specific expression of Sox9 in Cyprinus carpio · Du Qi-Yan Wang Feng-Yu Hua Hui-Ying Chang Zhong-Jie · More Details Abstract Fulltext PDF. The Sox9 gene is one of the important transcription factors in the development of many tissues and organs, particularly ...

  16. Colloque international 11 et 12 mai 2007, Université de Lausanne - French version only

    CERN Document Server

    2007-01-01

    Hannah Arendt, 100e anniversaire (1906-2006) Pouvoir, Guerre, Pensée et Jugement politique au XXe et XXIe siècles, (re)lire l'oeuvre d'Hannah Arendt aujourd'hui Conférences plénières, ateliers, soirée publique, exposition, musique, venez nombreux Informations sur le thème du Colloque et inscription sur la page web http://www.unil.ch/arendtsuisse2007

  17. Atlas de la science et de l'innovation dans le monde musulman ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    À travers les âges, les érudits et les chercheurs du monde musulman ont été des chefs de file dans les domaines de la médecine, de l'astronomie et des mathématiques. Aujourd'hui toutefois, de nombreux pays comptant une forte population musulmane se classent au-dessous de la moyenne mondiale en ce qui concerne ...

  18. Caféiculture : il faut veiller au grain | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    31 janv. 2011 ... Dans les années 1960, les tentatives visant à éliminer le cercle vicieux de la pauvreté dans lequel les caféiculteurs se trouvaient piégés ont donné naissance au mouvement en faveur du commerce équitable. Aujourd'hui, quelque 800 000 producteurs de plus de 45 pays travaillent en fonction des normes ...

  19. Répercussions de la libéralisation du commerce des services sur le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Répercussions de la libéralisation du commerce des services sur le développement. La documentation économique a démontré l'importance du secteur des services dans le processus de croissance économique et de développement social. Le principal défi auquel sont confrontés aujourd'hui les pays en développement ...

  20. Fait et chiffres sur l'alimentation et la biodiversité | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    alimentation et l'agriculture (FAO) estime que, sur près de 250 000 variétés végétales propres à la culture, on n'en cultive aujourd'hui qu'environ 7 000, soit moins de 3 %. Le non-usage mène à l'abandon et, éventuellement, ...

  1. L'étude des dangers : contenu, limites et spécificités françaises

    OpenAIRE

    Farret , Régis

    2008-01-01

    National audience; Il ne s'agit pas aujourd'hui de présenter par le menu ce qu'est une étude de dangers, mais de prendre un peu de recul pour exposer la méthode d'analyse des risques qu'est l'étude de dangers et de montrer les particularités françaises avec un regard sur ce qui passe ailleurs en Europe.

  2. Agriculture urbaine : Rosario, en Argentine, récolte les fruits de ses ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    7 oct. 2010 ... C'est en cultivant leur propre potager que des milliers de familles de la ville de Rosario, en Argentine, sont parvenues à se nourrir tout au long de la crise économique qui a récemment frappé leur pays. La ville compte aujourd'hui plus de 800 jardins communautaires qui, en plus de nourrir quelque 40 000 ...

  3. Réduction de la malnutrition et retour à une diversité biologique et ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le défi. En Inde, beaucoup de personnes pauvres vivent dans des régions rurales fortement tributaires de l'agriculture. Or, la grande diversité des cultures traditionnellement pratiquées dans ces régions est aujourd'hui fréquemment mise à mal par les politiques gouvernementales, qui encouragent la culture du riz et du blé.

  4. Changing patient safety culture in China: a case study of an experimental Chinese hospital from a comparative perspective

    OpenAIRE

    Xu XP; Deng DN; Gu YH; Ng CS; Cai X; Xu J; Zhang XS; Ke DG; Yu QH; Chan CK

    2018-01-01

    Xiao Ping Xu,* Dong Ning Deng,* Yong Hong Gu, Chui Shan Ng, Xiao Cai, Jun Xu, Xin Shi Zhang, Dong Ge Ke, Qian Hui Yu, Chi Kuen Chan Clinical Service Department, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China *These authors contributed equally to this work Background: The World Health Organization highlights that patient safety interventions are not lacking but that the local context affects their successful implementation. Increasing att...

  5. Treatment decision-making among breast cancer patients in Malaysia

    OpenAIRE

    Nies YH; Islahudin F; Chong WW; Abdullah N; Ismail F; Ahmad Bustamam RS; Wong YF; Saladina JJ; Mohamed Shah N

    2017-01-01

    Yong Hui Nies,1 Farida Islahudin,1 Wei Wen Chong,1 Norlia Abdullah,2 Fuad Ismail,3 Ros Suzanna Ahmad Bustamam,4 Yoke Fui Wong,5 JJ Saladina,2 Noraida Mohamed Shah1 1Faculty of Pharmacy, 2Department of Surgery, 3Department of Radiotherapy and Oncology, Universiti Kebangsaan Malaysia Medical Centre, 4Department of Radiotherapy and Oncology, Hospital Kuala Lumpur, Kuala Lumpur, 5Department of Radiotherapy and Oncology, National Cancer Institute, Putrajaya, Malaysia Purpose: This study investig...

  6. Asie | CRDI - Centre de recherches pour le développement ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... défis agricoles, environnementaux, technologiques, sociaux et économiques de l'Asie. Grâce à nos investissements stratégiques, nous aidons les acteurs régionaux à participer plus efficacement à résolution des problèmes régionaux. Qu'en résulte-t-il ? Des dirigeants régionaux forts, pour aujourd'hui et pour demain.

  7. « Le Virgile de l’Amérique »

    Directory of Open Access Journals (Sweden)

    Bernard Vincent

    2006-03-01

    Full Text Available Paul Goodman (1911-1972 est une importante figure du paysage intellectuel des années 40 à 60. On lui doit des ouvrages sur de nombreux sujets, dont la Gestalt Therapy (1951, mais il est aujourd’hui surtout connu pour son analyse de la jeunesse des années 50 dans Growing Up Absurd (1960 et pour son roman-fresque The Empire City (1959.

  8. Epistemic craftwork, or when is good journalism bad public relations?

    OpenAIRE

    Srader, Doyle

    2009-01-01

    In April 2007, Seung-Hui Cho mailed a video, several photographs and a lengthy written document to NBC News while in the middle of his infamous shooting spree at Virginia Tech. NBC News president Steve Capus decided to air the footage, which unleashed a torrent of criticism from citizens, law enforcement, commentators, and even Capus' fellow news executives at the other networks. I examine the argumentative exchange between Capus and his colleagues for clues about the professional ideal and e...

  9. [Variation of CAG repeats in coding region of ATXN2 gene in different ethnic groups].

    Science.gov (United States)

    Chen, Xiao-Chen; Sun, Hao; Mi, Dong-Qing; Huang, Xiao-Qin; Lin, Ke-Qin; Yi, Wen; Yu, Liang; Shi, Lei; Shi, Li; Yang, Zhao-Qing; Chu, Jia-You

    2011-04-01

    Toinvestigate CAG repeats variation of ATXN2 gene coding region in six ethnic groups that live in comparatively different environments, to evaluate whether these variations are under positive selection, and to find factors driving selection effects, 291 unrelated healthy individuals were collected from six ethnic groups and their STR geneotyping was performed. The frequencies of alleles and genotypes were counted and thereby Slatkin's linearized Fst values were calculated. The UPGMA tree against this gene was constructed. The MDS analysis among these groups was carried out as well. The results from the linearized Fst values indicated that there were significant evolutionary differences of the STR in ATXN2 gene between Hui and Yi groups, but not among the other 4 groups. Further analysis was performed by combining our data with published data obtained from other groups. These results indicated that there were significant differences between Japanese and other groups including Hui, Hani, Yunnan Mongolian, and Inner Mongolian. Both Hui and Mongolian from Inner Mongolia were significantly different from Han. In conclusion, the six ethnic groups had their own distribution characterizations of allelic frequencies of ATXN2 STR, and the potential cause of frequency changes in rare alleles could be the consequence of positive selection.

  10. Comparing population health in the United States and Canada

    Directory of Open Access Journals (Sweden)

    Huguet Nathalie

    2010-04-01

    Full Text Available Abstract Background The objective of the paper is to compare population health in the United States (US and Canada. Although the two countries are very similar in many ways, there are potentially important differences in the levels of social and economic inequality and the organization and financing of and access to health care in the two countries. Methods Data are from the Joint Canada/United States Survey of Health 2002/03. The Health Utilities Index Mark 3 (HUI3 was used to measure overall health-related quality of life (HRQL. Mean HUI3 scores were compared, adjusting for major determinants of health, including body mass index, smoking, education, gender, race, and income. In addition, estimates of life expectancy were compared. Finally, mean HUI3 scores by age and gender and Canadian and US life tables were used to estimate health-adjusted life expectancy (HALE. Results Life expectancy in Canada is higher than in the US. For those Conclusions The population of Canada appears to be substantially healthier than the US population with respect to life expectancy, HRQL, and HALE. Factors that account for the difference may include access to health care over the full life span (universal health insurance and lower levels of social and economic inequality, especially among the elderly.

  11. Changes in quality of life into adulthood after very preterm birth and/or very low birth weight in the Netherlands

    Science.gov (United States)

    2013-01-01

    Background It is important to know the impact of Very Preterm (VP) birth or Very Low Birth Weight (VLBW). The purpose of this study is to evaluate changes in Health-Related Quality of Life (HRQoL) of adults born VP or with a VLBW, between age 19 and age 28. Methods The 1983 nationwide Dutch Project On Preterm and Small for gestational age infants (POPS) cohort of 1338 VP (gestational age LHS) and the WHOQoL-BREF. Multiple imputation was applied to correct for missing data and non-response. Results The mean HUI3 and LHS scores did not change significantly from age 19 to age 28. However, after multiple imputation, a significant, though not clinically relevant, increase of 0.02 on the overall HUI3 score was found. The mean HRQoL score measured with the HUI3 increased from 0.83 at age 19 to 0.85 at age 28. The lowest score on the WHOQoL was the psychological domain (74.4). Conclusions Overall, no important changes in HRQoL between age 19 and age 28 were found in the POPS cohort. Psychological and emotional problems stand out, from which recommendation for interventions could be derived. PMID:23531081

  12. Multiattribute health utility scoring for the computerized adaptive measure CAT-5D-QOL was developed and validated.

    Science.gov (United States)

    Kopec, Jacek A; Sayre, Eric C; Rogers, Pamela; Davis, Aileen M; Badley, Elizabeth M; Anis, Aslam H; Abrahamowicz, Michal; Russell, Lara; Rahman, Md Mushfiqur; Esdaile, John M

    2015-10-01

    The CAT-5D-QOL is a previously reported item response theory (IRT)-based computerized adaptive tool to measure five domains (attributes) of health-related quality of life. The objective of this study was to develop and validate a multiattribute health utility (MAHU) scoring method for this instrument. The MAHU scoring system was developed in two stages. In phase I, we obtained standard gamble (SG) utilities for 75 hypothetical health states in which only one domain varied (15 states per domain). In phase II, we obtained SG utilities for 256 multiattribute states. We fit a multiplicative regression model to predict SG utilities from the five IRT domain scores. The prediction model was constrained using data from phase I. We validated MAHU scores by comparing them with the Health Utilities Index Mark 3 (HUI3) and directly measured utilities and by assessing between-group discrimination. MAHU scores have a theoretical range from -0.842 to 1. In the validation study, the scores were, on average, higher than HUI3 utilities and lower than directly measured SG utilities. MAHU scores correlated strongly with the HUI3 (Spearman ρ = 0.78) and discriminated well between groups expected to differ in health status. Results reported here provide initial evidence supporting the validity of the MAHU scoring system for the CAT-5D-QOL. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Gd-EOB-DTPA-enhanced MRI for monitoring future liver remnant function after portal vein embolization and extended hemihepatectomy: A prospective trial

    Energy Technology Data Exchange (ETDEWEB)

    Geisel, Dominik; Raabe, Philip; Hamm, Bernd; Denecke, Timm [Charite Campus Virchow-Klinikum, Department of Diagnostic and Interventional Radiology, Berlin (Germany); Luedemann, Lutz [Essen University Hospital, Department of Medical Physics, Essen (Germany); Malinowski, Maciej; Stockmann, Martin; Seehofer, Daniel; Pratschke, Johann [Charite Campus Virchow-Klinikum, Department of General, Visceral and Transplantation Surgery, Berlin (Germany)

    2017-07-15

    To evaluate changes in liver function after right portal vein embolization (PVE) and extended right hemihepatectomy using gadolinium ethoxybenzyl-DTPA-enhanced (Gd-EOB-DTPA) MRI. In this prospective trial, 37 patients undergoing PVE were examined before and 14 and 28 days after PVE and 10 days after extended hemihepatectomy using Gd-EOB-DTPA-enhanced MRI. Lobar volume, kinetic growth rate (KGR), relative enhancement (RE) as well as hepatocellular uptake index (HUI) and fat signal fraction (FSF) were calculated for each lobe. RE of the left liver lobe (LLL) was steadily increasing after PVE and decreased to 0.48 ± 0.19 10 days after surgery, which is significantly lower than 14 days and 28 days post PVE (P < 0.05). KGR was 14.06 ± 9.82%/week for the period from PVE to 14 days after PVE. HUI of the LLL increased steadily after PVE and was significantly higher at both 14 and 28 days after PVE compared to pre PVE (P < 0.05). HUI of the residual liver after surgery was lower than before. Gd-EOB-DTPA-enhanced MRI may be used to monitor the functional increase in the FLR after PVE and to depict the intraoperative liver injury leading to a decrease in liver remnant function. (orig.)

  14. Developmental immunotoxicity is not associated with the consumption of transgenic Bt rice TT51 in rats.

    Science.gov (United States)

    Hu, Jing; Liang, Chunlai; Zhang, Xiaopeng; Zhang, Qiannan; Cui, Wenming; Yu, Zhou

    2018-04-01

    TT51 is a transgenic strain of Bt rice generated by fusing a synthetic CryAb/Ac gene into MingHui rice. In this study, rats from F0, F1, and F2 generations were fed a diet with 60% TT51 rice, MingHui rice, or nominal-origin rice. The study focused on developmental immunotoxicity in F1 and F2 offspring after long-term consumption of TT51. A wide range of immunological parameters was monitored in this two-generation study on reproductive toxicity. The experiments were performed on F1 and F2 offspring at postnatal days 21 and 42. No adverse clinical effects were observed in any of the experimental groups. In addition, histopathology observations and immunotoxicity tests, including hematological indicators, spleen lymphocyte subsets, natural killer cell activity, lymphoproliferative response, and plaque-forming cell assay, revealed no significant difference between the groups. These results indicated that developmental immunotoxicity was not associated with a diet of transgenic Bt rice TT51, compared to the parental MingHui rice. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. L'argument Einstein Podolsky Rosen (EPR) paradoxe, alternative et demonstration

    CERN Document Server

    Roussel, P

    2003-01-01

    En physique quantique, l'absence d'observation d'etats de superposition ne devrait etre une surprise pour personne, que les objets soient microscopiques ou macroscopiques. Cela n'en etait pas une pour Schroedinger. L'experience de pensee "du chat" parmi bien d'autres arguments le montre clairement. On ne doit pas aujourd'hui lui faire dire le contraire. L'article EPR (A.Einstein, B.Podolsky,N.Rosen, ecrit en 1935), qui est a l'origine de l'intervention de Schroedinger et du developpement d'une problematique qui se prolonge jusqu'a aujourd'hui, est analyse. Avec Schroedinger, Bohr, Wigner et jusqu'a aujourd'hui, la reponse a EPR a ete le recours renouvele a l'observateur finalement caracterise par sa conscience. Deux elements nouveaux sont apparus: d'une part un developpement experimental et theorique impressionnant avec l'optique quantique et les manipulations d'atomes, d'autre part la proposition du concept de decoherence susceptible d'expliquer le passage du microscopique au macroscopique et par la d'apport...

  16. Assessing the Quality of Life Using the Health Utilities Index Questionnaire in Children With Severe Persistent Asthma During the Treatment With Omalizumab

    Directory of Open Access Journals (Sweden)

    Leyla S. Namazova-Baranova

    2017-01-01

    Full Text Available Background. Quality of life (QoL is an important parameter that provides additional information about changes in health status. Objective. Our aim was to study the change in QoL of patients with severe persistent bronchial asthma (BA during the treatment with genetically engineered biological preparation (GIBP omalizumab in addition to daily background therapy. Methods. The QoL assessment was conducted using the Health Utilities Index Mark 3 and Mark 2 (HUI3, HUI2 questionnaires at two points (1st point and 2nd point — in 6 months in 47 children with severe BA at the age of 13 (7; 17 years, 72% of them are boys. At the same points, QoL was evaluated using the PAQLQ (S specialized pediatric questionnaire (Standardized Pediatric Asthma Quality of Life Questionnaire. Results. Depending on the duration of omalizumab therapy, all children were divided into 5 groups: 1st group — children who did not receive treatment with monoclonal antibodies at the 1st point; in 2, 3, 4, 5-th groups, the QoL assessment was performed on GIBP treatment for different time. In children of the 1st group whose QoL was evaluated before starting GIBP therapy and in 6 months, a statistically significant change in scores on the Health Utilities Index questionnaire was noted: the multi-attribute indices HUI2 and HUI3 improved, respectively, by 21.3 and 10.71% (p = 0.041 and 0.086. According to the HUI2 classification system, a significant improvement in the emotion attribute was revealed, which positively correlated with the overall indicator and the emotion indicator of the PAQLQ (S questionnaire. In the remaining groups, the indicators of the Health Utilities Index questionnaire did not change significantly. Conclusion. The study results showed that the dynamics of the quality of life in children with severe persistent BA is an important additional criterion in a comprehensive assessment of the efficacy of targeted bioengineering therapy. 

  17. [Secular trends of height among Chinese students aged 17 in 18 ethnic minorities from 1985 to 2010].

    Science.gov (United States)

    Song, Yi; Hu, Pei-jin; Zhang, Bing; Ma, Jun

    2015-06-18

    To analyze the secular trends of height among Chinese students aged 17 in different ethnic minorities from 1985 to 2010. A total of 18 Chinese ethnic minorities' students, including Mongolian, Hui, Uygur, Zhuang, Korean, Tibetan, Miao, Buyi, Dong, Bai, Tujia, Hani, Dai, Lisu, Wa, Nakhi, Tu and Qiang as subjects were sampled from the 1985, 1995, 2000, 2005 and 2010 Chinese National Surveys on Students' Constitution and Health. The heights of 17 years old people by gender in various ethnic minorities were analyzed and compared. From 1985 to 2010, the increments of adult heights increased significantly in many ethnic minorities' boys. In 2010, the average height of boys aged 17 years in each minority group was higher than 162 cm and was higher than 170 cm among boys from Hui, Mongolian and Korean groups. The ethnics with height growth rates of more than 2 cm per decade in boys were Hui (2.64 cm/decade) and Dong (2.05 cm/decade) and the ethnics with height growth rates of more than 1 cm per decade were Korean (1.99 cm/decade), Tibetan (1.90 cm/decade), Hani (1.80 cm/decade) and the other 9 minority groups. The average height of girls aged 17 years in each minority group was higher than 150 cm in 2010. The heights showed an upward trend in 15 minority groups, but with different degrees. The ethnics with height growth rates of more than 1 cm per decade were Hui (1.56 cm/decade) and Korean (1.29 cm/decade). The increments that were significant between 1985 and 2010 were Hui (3.89 cm), Korean (3.23 cm), Dong (2.35 cm) and the other 6 minority groups (Pminority groups during the past 25 years, but there was an obvious disequilibrium among various ethnic minorities. We should pay more attention to the minority groups with poor growth and give them more help. Meanwhile, we should also pay attention to the negative effects of the secular growth trend on those minority groups with fast increasing adult height.

  18. A comparison of doctors', parents' and children's reports of health states and health-related quality of life in children with chronic conditions.

    Science.gov (United States)

    Morrow, A M; Hayen, A; Quine, S; Scheinberg, A; Craig, J C

    2012-03-01

    Health-related quality of life is an important outcome. Self-report is the gold standard, but in the paediatric setting we often rely on proxy reporting. Our understanding of the differences between self- and proxy reports and the factors that influence them is limited. These differences can impact on treatment choices and the patient-doctor relationship. To evaluate differences between children's, parents' and doctors' perceptions of health states and health-related quality of life in children with chronic illness and explore factors which explain these differences. Consecutive families attending eligible clinics at a tertiary paediatric centre were invited to complete the Health Utilities Index (HUI) 23 questionnaire. Percentage agreement and kappas were calculated as a measure of the agreement between pairs. Chi-squared tests or Fisher's exact test, if appropriate, were performed to determine if there was an association between level of agreement and participant variables. Data were collected for 130 parent-doctor pairs, 59 child-parent pairs and 59 child-doctor pairs. Overall health-related quality of life scores did not differ between responders, but there was poorer agreement for subjective domains. Doctor-child agreement was lower than parent-child agreement. Children with a diagnosis of cerebral palsy or chronic neurological condition were more likely to have lower inter-rater agreement for both subjective and objective domains. On the HUI2, agreement was lower for parent-child pairs when the father was the respondent. For child-doctor pairs, an increased frequency of patient-doctor visits and doctors' seniority were predictors of poorer agreement on the HUI3 and HUI2 respectively. We identified factors associated with level of agreement for self- and proxy reporting on the HUI23. Parent-child agreement was higher than doctor-child agreement. Patients with significant pain or emotional distress and patients with a diagnosis of severe cerebral palsy or

  19. Airborne gamma-ray spectrometer and magnetometer survey, Peoria quadrangle (IL). Final report

    International Nuclear Information System (INIS)

    1981-01-01

    Twenty-three uranium anomalies meet the minimum statistical requirements as defined in Volume I. These anomalies are listed and are shown on the Uranium Anomaly Interpretation Map. Potassium (%K), equivalent Uranium (ppM eU), equivalent Thorium (ppM eTh), eU/eTh, eU/K, eTh/K, and magnetic pseudo-contour maps are presented in Appendix E. Stacked Profiles showing geologic strip maps along each flight-line, together with sensor data, and ancillary data are presented in Appendix F. All maps and profiles were prepared on a scale of 1:250,000, but have been reduced to 1:500,000 for presentation in Volume II. Anomalies No. 1 and No. 2, and No. 19 are over areas underlain by the Radnor Till member (Qti) of the Pleistocene Glasford formation. Anomalies No. 3 and No. 5 are over areas underlain by Pleistocene moraine and other deposits of the Fairgrange Till member (Qwf, Qwfm) of the Wedron formation. Anomaly No. 4 is over an area underlain by the Pleistocene Batestown Till member (Qwb) of the Wedron formation. Anomalies No. 6 and No. 7 are over areas underlain by the Delavan Till member (Qwd) of the Pleistocene Wedron formation. Anomalies No. 8 and No. 20 are over areas underlain by Pleistocene moraine deposits of the Yorkville Till member (Qwym) of the Wedron formation. Anomalies No. 9, No. 12, and No. 14 are over areas underlain by Pleistocene moraine deposits of the Snider Till member (Qwsm) of the Wedron formation. Anomalies No. 10, and No. 15 to No. 16 are over areas underlain by the Snider Till member (Qws) of the Wedron formation of Pleistocene age. Anomaly No. 11 is over an area underlain by the Pleistocene Snider Till member (Qws) of the Wedron formation and Cahokia Alluvium

  20. Insight and Treatment Outcomes in Schizophrenia: Post-hoc Analysis of a Long-term, Double-blind Study Comparing Lurasidone and Quetiapine XR.

    Science.gov (United States)

    Harvey, Philip D; Siu, Cynthia O; Loebel, Antony D

    2017-12-01

    Objective: The objective of this post-hoc analysis was to evaluate the effect of lurasidone and quetiapine extended-release (XR) on insight and judgment and assess the longitudinal relationships between improvement in insight and cognitive performance, functional capacity, quality of well-being, and depressive symptoms in patients with schizophrenia. Design: Clinically unstable patients with schizophrenia (N=488) were randomized to once-daily, fixed-dose treatment with lurasidone 80mg, lurasidone 160mg, quetiapine XR 600mg, or placebo, followed by a long-term, double-blind, flexible-dose continuation study involving these agents. Results: Significantly greater improvement in insight and judgment (assessed by the Positive and Negative Syndrome Scale G12 item) for the lurasidone and quetiapine XR groups, compared to the placebo group, was observed at Week 6. Over a subsequent six-month continuation period, the flexible dose lurasidone group showed significantly greater improvement in insight from acute phase baseline compared to the flexible-dose quetiapine XR group (QXR-QXR) (p=0.032). Improvement in insight was significantly correlated with improvement in cognition ( p =0.014), functional capacity (p=0.006, UPSA-B), quality of well-being ( p =0.033, QWB), and depressive symptoms ( p =0.05, Montgomery-Åsberg Depression Rating Scale [MADRS] score) across treatment groups and study periods. Conclusion: In this post-hoc analysis, flexibly dosed lurasidone 40 to 160mg/d was found to be associated with significantly greater improvement in insight compared to flexibly dosed quetiapine XR 200 to 800mg/d over long-term treatment in patients with schizophrenia. Across treatment groups, improvement in insight and judgment was significantly associated with improvement in cognition, functional capacity, quality of well-being, and depressive symptoms over time.

  1. Clinical correlates of health preference and generic health-related quality of life in patients with colorectal neoplasms.

    Directory of Open Access Journals (Sweden)

    Carlos K H Wong

    Full Text Available BACKGROUND: The aims of the study were to assess the health preference and health-related quality of life (HRQOL in patients with colorectal neoplasms (CRN, and to determine the clinical correlates that significantly influence the HRQOL of patients. METHODS: Five hundred and fifty-four CRN patients, inclusive of colorectal polyp or cancer, who attended the colorectal specialist outpatient clinic at Queen Mary Hospital in Hong Kong between October 2009 and July 2010, were included. Patients were interviewed with questionnaires on socio-demographic characteristics, and generic and health preference measures of HRQOL using the SF-12 and SF-6D Health Surveys, respectively. Clinical information on stage of disease at diagnosis, time since diagnosis, primary tumour site was extracted from electronic case record. Mean HRQOL and health preference scores of CRN patients were compared with age-sex matched controls from the Chinese general population using independent t-test. Multiple linear regression analyses were conducted to explore the associations of clinical characteristics with HRQOL measures with the adjustment of socio-demographic characteristics. RESULTS: Cross-sectional data of 515 eligible patients responded to the whole questionnaires were included in outcome analysis. In comparison with age-sex matched normative values, CRN patients reported comparable physical-related HRQOL but better mental-related HRQOL. Amongst CRN patients, time since diagnosis was positively associated with health preference score whilst patients with rectal neoplasms had lower health preference and physical-related HRQOL scores than those with sigmoid neoplasms. Health preference and HRQOL scores were significantly lower in patients with stage IV colorectal cancer than those with other less severe stages, indicating that progressive decline from low-risk polyp to stage IV colorectal cancer was observed in HRQOL scores. CONCLUSION: In CRN patients, a more advanced

  2. Effectiveness and Cost-Effectiveness of Occupation-Based Occupational Therapy Using the Aid for Decision Making in Occupation Choice (ADOC) for Older Residents: Pilot Cluster Randomized Controlled Trial

    Science.gov (United States)

    Nagayama, Hirofumi; Tomori, Kounosuke; Ohno, Kanta; Takahashi, Kayoko; Ogahara, Kakuya; Sawada, Tatsunori; Uezu, Sei; Nagatani, Ryutaro; Yamauchi, Keita

    2016-01-01

    Background Care-home residents are mostly inactive, have little interaction with staff, and are dependent on staff to engage in daily occupations. We recently developed an iPad application called the Aid for Decision-making in Occupation Choice (ADOC) to promote shared decision-making in activities and occupation-based goal setting by choosing from illustrations describing daily activities. This study aimed to evaluate if interventions based on occupation-based goal setting using the ADOC could focus on meaningful activities to improve quality of life and independent activities of daily living, with greater cost-effectiveness than an impairment-based approach as well as to evaluate the feasibility of conducting a large cluster, randomized controlled trial. Method In this single (assessor)-blind pilot cluster randomized controlled trial, the intervention group (ADOC group) received occupational therapy based on occupation-based goal setting using the ADOC, and the interventions were focused on meaningful occupations. The control group underwent an impairment-based approach focused on restoring capacities, without goal setting tools. In both groups, the 20-minute individualized intervention sessions were conducted twice a week for 4 months. Main Outcome Measures Short Form-36 (SF-36) score, SF-6D utility score, quality adjusted life years (QALY), Barthel Index, and total care cost. Results We randomized and analyzed 12 facilities (44 participants, 18.5% drop-out rate), with 6 facilities each allocated to the ADOC (n = 23) and control (n = 21) groups. After the 4-month intervention, the ADOC group had a significantly greater change in the BI score, with improved scores (P = 0.027, 95% CI 0.41 to 6.87, intracluster correlation coefficient = 0.14). No other outcome was significantly different. The incremental cost-effectiveness ratio, calculated using the change in BI score, was $63.1. Conclusion The results suggest that occupational therapy using the ADOC for older

  3. An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Martyn Lewis

    Full Text Available The TATE trial was a multicentre pragmatic randomized controlled trial of supplementing primary care management (PCM-consisting of a GP consultation followed by information and advice on exercises-with transcutaneous electrical nerve stimulation (TENS, to reduce pain intensity in patients with tennis elbow. This paper reports the health economic evaluation.Adults with new diagnosis of tennis elbow were recruited from 38 general practices in the UK, and randomly allocated to PCM (n = 120 or PCM plus TENS (n = 121. Outcomes included reduction in pain intensity and quality-adjusted-life-years (QALYs based on the EQ5D and SF6D. Two economic perspectives were evaluated: (i healthcare-inclusive of NHS and private health costs for the tennis elbow; (ii societal-healthcare costs plus productivity losses through work absenteeism. Mean outcome and cost differences between the groups were evaluated using a multiple imputed dataset as the base case evaluation, with uncertainty represented in cost-effectiveness planes and through probabilistic cost-effectiveness acceptability curves. Incremental healthcare cost was £33 (95%CI -40, 106 and societal cost £65 (95%CI -307, 176 for PCM plus TENS. Mean differences in outcome were: 0.11 (95%CI -0.13, 0.35 for change in pain (0-10 pain scale; -0.015 (95%CI -0.058, 0.029 for QALYEQ5D; 0.007 (95%CI -0.022, 0.035 for QALYSF6D (higher score differences denote greater benefit for PCM plus TENS. The ICER (incremental cost effectiveness ratio for the main evaluation of mean difference in societal cost (£ relative to mean difference in pain outcome was -582 (95%CI -8666, 8113. However, incremental ICERs show differences in cost-effectiveness of additional TENS, according to the outcome being evaluated.Our findings do not provide evidence for or against the cost-effectiveness of TENS as an adjunct to primary care management of tennis elbow.

  4. Economic and Health-Related Quality of Life Outcomes of Whiplash Associated Disorders.

    Science.gov (United States)

    Pink, Joshua; Petrou, Stavros; Williamson, Esther; Williams, Mark; Lamb, Sarah E

    2016-09-01

    This study examines the links between severity of whiplash associated disorder and costs and health outcomes. The study aims to estimate the economic costs and health-state utilities associated with disability levels and recovery trajectories after acute whiplash injury. Data used were from the Managing Injuries of the Neck Trial, which collected information on 3851 people over a 12-month period after acute whiplash injury. Effects of whiplash associated disorder severity on economic costs (measured from a societal perspective and separately from a health and personal social services perspective) were estimated using two-part regression models, comprising probability of incurring a cost and the total cost, given one was incurred. Effects on health-state utilities (measured using the EQ-5D and SF-6D) were estimated using ordinary least squares regression, and two-part models as for costs. There was a direct relationship between severity of disability after acute whiplash injury and economic costs. Between baseline and 4 months, average societal costs for those with no disability were £99.55 (UK£, 2009 prices), increasing to £668.53 for those with complete disability. Average societal costs for the whole sample were £234.15 over the first 4 months, decreasing to £127.51 between 8 and 12 months. Conversely, utility scores decreased with increased disability. The average EQ-5D utility score was 0.934 at 4 months for those with no disability, decreasing to 0.033 for those with complete disability. The average EQ-5D utility score for the whole sample increased from 0.587 immediately post-injury to 0.817 at 12 months. Relative costs and disutilities generated by the multivariate models are also presented by disability level and recovery trajectory. These results provide estimates of the costs and health-state utilities associated with disability levels and recovery trajectories after acute whiplash injury. They can be used to inform estimates of the cost

  5. A randomised controlled trial of CPAP versus non-invasive ventilation for initial treatment of obesity hypoventilation syndrome.

    Science.gov (United States)

    Howard, Mark E; Piper, Amanda J; Stevens, Bronwyn; Holland, Anne E; Yee, Brendon J; Dabscheck, Eli; Mortimer, Duncan; Burge, Angela T; Flunt, Daniel; Buchan, Catherine; Rautela, Linda; Sheers, Nicole; Hillman, David; Berlowitz, David J

    2017-05-01

    Obesity hypoventilation syndrome (OHS) is the most common indication for home ventilation, although the optimal therapy remains unclear, particularly for severe disease. We compared Bi-level and continuous positive airways pressure (Bi-level positive airway pressure (PAP); CPAP) for treatment of severe OHS. We conducted a multicentre, parallel, double-blind trial for initial treatment of OHS, with participants randomised to nocturnal Bi-level PAP or CPAP for 3 months. The primary outcome was frequency of treatment failure (hospital admission, persistent ventilatory failure or non-adherence); secondary outcomes included health-related quality of life (HRQoL) and sleepiness. Sixty participants were randomised; 57 completed follow-up and were included in analysis (mean age 53 years, body mass index 55 kg/m 2 , PaCO 2 60 mm Hg). There was no difference in treatment failure between groups (Bi-level PAP, 14.8% vs CPAP, 13.3%, p=0.87). Treatment adherence and wake PaCO 2 were similar after 3 months (5.3 hours/night Bi-level PAP, 5.0 hours/night CPAP, p=0.62; PaCO 2 44.2 and 45.9 mm Hg, respectively, p=0.60). Between-group differences in improvement in sleepiness (Epworth Sleepiness Scale 0.3 (95% CI -2.8, 3.4), p=0.86) and HRQoL (Short Form (SF)36-SF6d 0.025 (95% CI -0.039, 0.088), p=0.45) were not significant. Baseline severity of ventilatory failure (PaCO 2 ) was the only significant predictor of persistent ventilatory failure at 3 months (OR 2.3, p=0.03). In newly diagnosed severe OHS, Bi-level PAP and CPAP resulted in similar improvements in ventilatory failure, HRQoL and adherence. Baseline PaCO 2 predicted persistent ventilatory failure on treatment. Long-term studies are required to determine whether these treatments have different cost-effectiveness or impact on mortality. ACTRN12611000874910, results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  6. Factors associated with health-related quality of life of student pharmacists.

    Science.gov (United States)

    Payakachat, Nalin; Gubbins, Paul O; Ragland, Denise; Flowers, Schwanda K; Stowe, Cindy D

    2014-02-12

    To assess the health-related quality of life (HRQoL) of student pharmacists and explore factors related to HRQoL outcomes of student pharmacists in a doctor of pharmacy (PharmD) program at a public university. A survey instrument was administered to all student pharmacists in a PharmD program at a public university to evaluate differences and factors related to the HRQoL outcomes of first-year (P1), second-year (P2), third-year (P3), and fourth-year (P4) student pharmacists in the college. The survey instrument included attitudes and academic-related self-perception, a 12-item short form health survey, and personal information components. There were 304 students (68.6%) who completed the survey instrument. The average health state classification measure and mental health component scale (MCS-12) scores were significantly higher for P4 students when compared with the P1through P3 students. There was no difference observed in the physical component scale (PCS-12) scores among each of the 4 class years. Significant negative impact on HRQoL outcomes was observed in students with higher levels of confusion about how they should study (scale lack of regulation) and concern about not being negatively perceived by others (self-defeating ego orientation), while school satisfaction increased HRQoL outcomes (SF-6D, p<0.001; MCS-12, p=0.013). A greater desire to be judged capable (self-enhancing ego-orientation) and career satisfaction were positively associated with the PCS-12 scores (p<0.05). Factors associated with the HRQoL of student pharmacists were confusion regarding how to study, ego orientation, satisfaction with the chosen college of pharmacy, and career satisfaction. First-year through third-year student pharmacists had lower HRQoL as compared with P4 students and the US general population. Support programs may be helpful for students to maintain or improve their mental and overall health.

  7. Evaluation of a structured goal planning and tailored follow-up programme in rehabilitation for patients with rheumatic diseases: protocol for a pragmatic, stepped-wedge cluster randomized trial

    Science.gov (United States)

    2014-01-01

    Background Comprehensive rehabilitation, involving health professionals from various disciplines, is widely used as an adjunct to pharmacological and surgical treatment in people with rheumatic diseases. However, the evidence for the clinical- and cost-effectiveness of such interventions is limited, and the majority of those who receive rehabilitation are back to their initial health status six to 12 months after discharge. Methods/design To evaluate the goal attainment, health effects and cost-effectiveness of a new rehabilitation programme compared to current traditional rehabilitation programmes for people with rheumatic diseases, a stepped-wedge cluster randomized trial will be performed. Patients admitted for rehabilitation at six centres in the south-eastern part of Norway will be invited to participate. In the trial, six participating centres will switch from a control (current rehabilitation programme) to an intervention phase (the new rehabilitation programme) in a randomized order. Supported by recent research, the new programme will be a supplement to the existing programme at each centre, and will comprise four elements designed to enhance and support lifestyle changes introduced in the rehabilitation period: structured goal-planning, motivational interviewing, a self-help booklet and four follow-up telephone calls during the first five months following discharge. The primary outcome will be health-related quality of life and goal attainment, as measured by the Patient Generated Index directly before and after the rehabilitation stay, as well as after six and 12 months. Secondary outcomes will include self-reported pain, fatigue, a global assessment of disease activity and motivation for change (measured on 11-point numeric ratings scales), health-related quality of life as measured by the Short Form 36 Health Survey (SF-36) and utility assessed by the SF6D utility index. The main analysis will be on an intention to treat basis and will assess the

  8. Pain, health related quality of life and healthcare resource utilization in Spain.

    Science.gov (United States)

    Langley, Paul; Pérez Hernández, Concepción; Margarit Ferri, César; Ruiz Hidalgo, Domingo; Lubián López, Manuel

    2011-01-01

    The aim of this paper is to consider the relationship between the experience of pain, health related quality of life (HRQoL) and healthcare resource utilization in Spain. The analysis contrasts the contribution of pain severity and frequency of pain reported against respondents reporting no pain in the previous month. Data are from the 2010 National Health and Wellness Survey (NHWS) for Spain. Single equation generalized linear regression models are used to evaluate the association of pain with the physical and mental component scores of the SF-12 questionnaire as well as health utilities generated from the SF-6D. In addition, the role of pain is assessed in its association with self-reported healthcare provider visits, emergency room visits and hospitalizations in the previous 6 months. The results indicate that the experience of pain, notably severe and frequent pain, is substantial and is significantly associated with the SF-12 physical component scores, health utilities and all aspects of healthcare resource utilization, which far outweighs the role of demographic and socioeconomic variables, health risk factors (in particular body mass index) and the presence of comorbidities. In the case of severe daily pain, the marginal contribution of the SF-12 physical component score is a deficit of -17.86 compared to those reporting no pain (population average score 46.49), while persons who are morbidly obese report a deficit of only -6.63 compared to those who are normal weight. The corresponding association with health utilities is equally dramatic with a severe daily pain deficit of -0.186 compared to those reporting no pain (average population utility 0.71). The impact of pain on healthcare resource utilization is marked. Severe daily pain increases traditional provider visits by 208.8%, emergency room visits by 373.0% and hospitalizations by 348.5%. As an internet-based survey there is the possibility of bias towards those with internet access, although telephone

  9. Effect of personalised citizen assistance for social participation (APIC) on older adults' health and social participation: study protocol for a pragmatic multicentre randomised controlled trial (RCT).

    Science.gov (United States)

    Levasseur, Mélanie; Dubois, Marie-France; Filliatrault, Johanne; Vasiliadis, Helen-Maria; Lacasse-Bédard, Joanie; Tourigny, André; Levert, Marie-Josée; Gabaude, Catherine; Lefebvre, Hélène; Berger, Valérie; Eymard, Chantal

    2018-03-31

    The challenges of global ageing and the growing burden of chronic diseases require innovative interventions acting on health determinants like social participation. Many older adults do not have equitable opportunities to achieve full social participation, and interventions might underempower their personal and environmental resources and only reach a minority. To optimise current practices, the Accompagnement-citoyen Personnalisé d'Intégration Communautaire (APIC), an intervention demonstrated as being feasible and having positive impacts, needs further evaluation. A pragmatic multicentre, prospective, two-armed, randomised controlled trial will evaluate: (1) the short-term and long-term effects of the APIC on older adults' health, social participation, life satisfaction and healthcare services utilisation and (2) its cost-effectiveness. A total of 376 participants restricted in at least one instrumental activity of daily living and living in three large cities in the province of Quebec, Canada, will be randomly assigned to the experimental or control group using a centralised computer-generated random number sequence procedure. The experimental group will receive weekly 3-hour personalised stimulation sessions given by a trained volunteer over the first 12 months. Sessions will encourage empowerment, gradual mobilisation of personal and environmental resources and community integration. The control group will receive the publicly funded universal healthcare services available to all Quebecers. Over 2 years (baseline and 12, 18 and 24 months later), self-administered questionnaires will assess physical and mental health (primary outcome; version 2 of the 36-item Short-Form Health Survey, converted to SF-6D utility scores for quality-adjusted life years), social participation (Social Participation Scale) and life satisfaction (Life Satisfaction Index-Z). Healthcare services utilisation will be recorded and costs of each intervention calculated. The Research

  10. Application and measurement properties of EQ-5D to measure quality of life in patients with upper extremity orthopaedic disorders: a systematic literature review.

    Science.gov (United States)

    Grobet, Cécile; Marks, Miriam; Tecklenburg, Linda; Audigé, Laurent

    2018-04-13

    The EuroQol-5 Dimension (EQ-5D) is the most widely used generic instrument to measure quality of life (QoL), yet its application in upper extremity orthopaedics as well as its measurement properties remain largely undefined. We implemented a systematic literature review to provide an overview of the application of EQ-5D in patients with upper extremity disorders and analyse its measurement properties. We searched Medline, EMBASE, Cochrane and Scopus databases for clinical studies including orthopaedic patients with surgical interventions of the upper extremity who completed the EQ-5D. For all included studies, the use of EQ-5D and quantitative QoL data were described. Validation studies of EQ-5D were assessed according to COSMIN guidelines and standard measurement properties were examined. Twenty-three studies were included in the review, 19 of which investigated patients with an intervention carried out at the shoulder region. In 15 studies, EQ-5D assessed QoL as the primary outcome. Utility index scores in non-trauma patients generally improved postoperatively, whereas trauma patients did not regain their recalled pre-injury QoL levels. EQ-5D measurement properties were reported in three articles on proximal humerus fractures and carpal tunnel syndrome. Positive ratings were seen for construct validity (Spearman correlation coefficient ≥ 0.70 with the Short Form (SF)-12 or SF-6D health surveys) and reliability (intraclass correlation coefficient ≥ 0.77) with intermediate responsiveness (standardised response means: 0.5-0.9). However, ceiling effects were identified with 16-48% of the patients scoring the maximum QoL. The methodological quality of the three articles varied from fair to good. For surgical interventions of the upper extremity, EQ-5D was mostly applied to assess QoL as a primary outcome in patients with shoulder disorders. Investigations of the measurement properties were rare, but indicate good reliability and validity as well as

  11. The effectiveness of a training for patients with unexplained physical symptoms: protocol of a cognitive behavioral group training and randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Passchier Jan

    2009-07-01

    Full Text Available Abstract Background In primary care, up to 74% of physical symptoms is classified as unexplained. These symptoms can cause high levels of distress and healthcare utilization. Cognitive behavioral therapy has shown to be effective, but does not seem to be attractive to patients. An exception herein is a therapy based on the consequences model, which distinguishes itself by its labeling of psychosocial distress in terms of consequences rather than as causes of physical symptoms. In secondary care, 81% of the patients accepts this therapy, but in primary care the outcome is poor. We assume that positive outcome can also be reached in primary care, when the consequences model is modified and used bottom-up in an easily accessible group training, in which patients are relieved of being blamed for their symptoms. Our aim is to investigate the (cost-effectiveness of this training. Methods and design A randomized controlled trial is designed. One hundred patients are randomized to either the group training or the waiting list. Physicians in general practices and outpatients clinics of general hospitals refer patients. Referral leads to inclusion if patients are between 18 and 65 years old, understand Dutch, have no handicaps impeding participation and the principal DSM-IV-TR classification is undifferentiated somatoform disorder or chronic pain disorder. In contrast to other treatment effect studies, the co-morbidity of a personality disorder does not lead to exclusion. By this, we optimize the comparability between the study population and patients in daily practice enlarging the generalization possibilities. Also in contrast to other effect studies, we chose quality of life (SF-36 instead of physical symptoms as the primary outcome measure. The SF-6D is used to estimate Quality Adjusted Life Years (QALYs. Costs are measured with the Trimbos/iMTA Questionnaire for Costs associated with Psychiatric Illness. Measurements are scheduled at baseline, after

  12. Pharmacist-led management of chronic pain in primary care: costs and benefits in a pilot randomised controlled trial.

    Science.gov (United States)

    Neilson, Aileen R; Bruhn, Hanne; Bond, Christine M; Elliott, Alison M; Smith, Blair H; Hannaford, Philip C; Holland, Richard; Lee, Amanda J; Watson, Margaret; Wright, David; McNamee, Paul

    2015-04-01

    To explore differences in mean costs (from a UK National Health Service perspective) and effects of pharmacist-led management of chronic pain in primary care evaluated in a pilot randomised controlled trial (RCT), and to estimate optimal sample size for a definitive RCT. Regression analysis of costs and effects, using intention-to-treat and expected value of sample information analysis (EVSI). Six general practices: Grampian (3); East Anglia (3). 125 patients with complete resource use and short form-six-dimension questionnaire (SF-6D) data at baseline, 3 months and 6 months. Patients were randomised to either pharmacist medication review with face-to-face pharmacist prescribing or pharmacist medication review with feedback to general practitioner or treatment as usual (TAU). Differences in mean total costs and effects measured as quality-adjusted life years (QALYs) at 6 months and EVSI for sample size calculation. Unadjusted total mean costs per patient were £452 for prescribing (SD: £466), £570 for review (SD: £527) and £668 for TAU (SD: £1333). After controlling for baseline costs, the adjusted mean cost differences per patient relative to TAU were £77 for prescribing (95% CI -82 to 237) and £54 for review (95% CI -103 to 212). Unadjusted mean QALYs were 0.3213 for prescribing (SD: 0.0659), 0.3161 for review (SD: 0.0684) and 0.3079 for TAU (SD: 0.0606). Relative to TAU, the adjusted mean differences were 0.0069 for prescribing (95% CI -0.0091 to 0.0229) and 0.0097 for review (95% CI -0.0054 to 0.0248). The EVSI suggested the optimal future trial size was between 460 and 690, and between 540 and 780 patients per arm using a threshold of £30,000 and £20,000 per QALY gained, respectively. Compared with TAU, pharmacist-led interventions for chronic pain appear more costly and provide similar QALYs. However, these estimates are imprecise due to the small size of the pilot trial. The EVSI indicates that a larger trial is necessary to obtain more

  13. The 5-year cost-effectiveness of two-level anterior cervical discectomy and fusion or cervical disc replacement: a Markov analysis.

    Science.gov (United States)

    Overley, Samuel C; McAnany, Steven J; Brochin, Robert L; Kim, Jun S; Merrill, Robert K; Qureshi, Sheeraz A

    2018-01-01

    Anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (CDR) are both acceptable surgical options for the treatment of cervical myelopathy and radiculopathy. To date, there are limited economic analyses assessing the relative cost-effectiveness of two-level ACDF versus CDR. The purpose of this study was to determine the 5-year cost-effectiveness of two-level ACDF versus CDR. The study design is a secondary analysis of prospectively collected data. Patients in the Prestige cervical disc investigational device exemption (IDE) study who underwent either a two-level CDR or a two-level ACDF were included in the study. The outcome measures were cost and quality-adjusted life years (QALYs). A Markov state-transition model was used to evaluate data from the two-level Prestige cervical disc IDE study. Data from the 36-item Short Form Health Survey were converted into utilities using the short form (SF)-6D algorithm. Costs were calculated from the payer perspective. QALYs were used to represent effectiveness. A probabilistic sensitivity analysis (PSA) was performed using a Monte Carlo simulation. The base-case analysis, assuming a 40-year-old person who failed appropriate conservative care, generated a 5-year cost of $130,417 for CDR and $116,717 for ACDF. Cervical disc replacement and ACDF generated 3.45 and 3.23 QALYs, respectively. The incremental cost-effectiveness ratio (ICER) was calculated to be $62,337/QALY for CDR. The Monte Carlo simulation validated the base-case scenario. Cervical disc replacement had an average cost of $130,445 (confidence interval [CI]: $108,395-$152,761) with an average effectiveness of 3.46 (CI: 3.05-3.83). Anterior cervical discectomy and fusion had an average cost of $116,595 (CI: $95,439-$137,937) and an average effectiveness of 3.23 (CI: 2.84-3.59). The ICER was calculated at $62,133/QALY with respect to CDR. Using a $100,000/QALY willingness to pay (WTP), CDR is the more cost-effective strategy and would be selected

  14. Cost-effectiveness of cervical total disc replacement vs fusion for the treatment of 2-level symptomatic degenerative disc disease.

    Science.gov (United States)

    Ament, Jared D; Yang, Zhuo; Nunley, Pierce; Stone, Marcus B; Kim, Kee D

    2014-12-01

    Cervical total disc replacement (CTDR) was developed to treat cervical spondylosis, while preserving motion. While anterior cervical discectomy and fusion (ACDF) has been the standard of care for 2-level disease, a randomized clinical trial (RCT) suggested similar outcomes. Cost-effectiveness of this intervention has never been elucidated. To determine the cost-effectiveness of CTDR compared with ACDF. Data were derived from an RCT that followed up 330 patients over 24 months. The original RCT consisted of multi-institutional data including private and academic institutions. Using linear regression for the current study, health states were constructed based on the stratification of the Neck Disability Index and a visual analog scale. Data from the 12-item Short-Form Health Survey questionnaires were transformed into utilities values using the SF-6D mapping algorithm. Costs were calculated by extracting Diagnosis-Related Group codes from institutional billing data and then applying 2012 Medicare reimbursement rates. The costs of complications and return-to-work data were also calculated. A Markov model was built to evaluate quality-adjusted life-years (QALYs) for both treatment groups. The model adopted a third-party payer perspective and applied a 3% annual discount rate. Patients included in the original RCT had to be diagnosed as having radiculopathy or myeloradiculopathy at 2 contiguous levels from C3-C7 that was unresponsive to conservative treatment for at least 6 weeks or demonstrated progressive symptoms. Incremental cost-effectiveness ratio of CTDR compared with ACDF. A strong correlation (R2 = 0.6864; P sensitivity analysis, the incremental cost-effectiveness ratio value stays below the threshold of $50,000 per QALY in most scenarios (range, -$58,194 to $147,862 per QALY). The incremental cost-effectiveness ratio of CTDR compared with traditional ACDF is lower than the commonly accepted threshold of $50,000 per QALY. This remains true with varying input

  15. Cost Utility Analysis of the Cervical Artificial Disc vs Fusion for the Treatment of 2-Level Symptomatic Degenerative Disc Disease: 5-Year Follow-up.

    Science.gov (United States)

    Ament, Jared D; Yang, Zhuo; Nunley, Pierce; Stone, Marcus B; Lee, Darrin; Kim, Kee D

    2016-07-01

    The cervical total disc replacement (cTDR) was developed to treat cervical degenerative disc disease while preserving motion. Cost-effectiveness of this intervention was established by looking at 2-year follow-up, and this update reevaluates our analysis over 5 years. Data were derived from a randomized trial of 330 patients. Data from the 12-Item Short Form Health Survey were transformed into utilities by using the SF-6D algorithm. Costs were calculated by extracting diagnosis-related group codes and then applying 2014 Medicare reimbursement rates. A Markov model evaluated quality-adjusted life years (QALYs) for both treatment groups. Univariate and multivariate sensitivity analyses were conducted to test the stability of the model. The model adopted both societal and health system perspectives and applied a 3% annual discount rate. The cTDR costs $1687 more than anterior cervical discectomy and fusion (ACDF) over 5 years. In contrast, cTDR had $34 377 less productivity loss compared with ACDF. There was a significant difference in the return-to-work rate (81.6% compared with 65.4% for cTDR and ACDF, respectively; P = .029). From a societal perspective, the incremental cost-effective ratio (ICER) for cTDR was -$165 103 per QALY. From a health system perspective, the ICER for cTDR was $8518 per QALY. In the sensitivity analysis, the ICER for cTDR remained below the US willingness-to-pay threshold of $50 000 per QALY in all scenarios (-$225 816 per QALY to $22 071 per QALY). This study is the first to report the comparative cost-effectiveness of cTDR vs ACDF for 2-level degenerative disc disease at 5 years. The authors conclude that, because of the negative ICER, cTDR is the dominant modality. ACDF, anterior cervical discectomy and fusionAWP, average wholesale priceCE, cost-effectivenessCEA, cost-effectiveness analysisCPT, Current Procedural TerminologycTDR, cervical total disc replacementCUA, cost-utility analysisDDD, degenerative disc disease

  16. Epilepsy and its Impact on psychosocial outcomes in Canadian children: Data from the National Longitudinal Study of Children and Youth (NLSCY).

    Science.gov (United States)

    Prasad, A N; Corbett, B

    2016-12-01

    The purpose of this study was to use data from a population-based survey to evaluate the association between childhood epilepsy and social outcomes through tests of mathematics skills, and sense of general self-esteem (GSS). Using data from Cycles 1 to 8 of the National Longitudinal Survey of Children and Youth (NLSCY), Hierarchical linear modeling (HLM) was used to compare baseline math scores and changes in math scores and sense of general self esteem (GSS) over time in children with and without epilepsy. Scores of Health Utility Index (HUI) were factored into the analysis. Children with epilepsy do not significantly differ in their scaled math scores in comparison to their peers without epilepsy, at age 12; however, in the two level HLM model the children with epilepsy lagged behind the healthy comparison group in terms of their growth in acquiring knowledge in mathematics. Additionally, when children with epilepsy carry an added health impairment as measured by an imperfect health utility (HUI) score the group shows a slower rate of growth in their math scores over time. Self-esteem measures show variable effects in children with epilepsy alone, and those with added health impairments. The interaction with HUI scores shows a significant negative effect on self-esteem, when epilepsy is associated with added health impairment. The findings suggest that the population of Canadian children surveyed with epilepsy are vulnerable to poorer academic outcomes in mathematics in later years, and this problem is compounded further with the presence of other additional health impairments. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Outcomes at 7 years for babies who developed neonatal necrotising enterocolitis: the ORACLE Children Study.

    Science.gov (United States)

    Pike, Katie; Brocklehurst, Peter; Jones, David; Kenyon, Sarah; Salt, Alison; Taylor, David; Marlow, Neil

    2012-09-01

    Within the ORACLE Children Study Cohort, the authors have evaluated long-term consequences of the diagnosis of confirmed or suspected neonatal necrotising enterocolitis (NEC) at age of 7 years. Outcomes were assessed using a parental questionnaire, including the Health Utilities Index (HUI-3) to assess functional impairment, and specific medical and behavioural outcomes. Educational outcomes for children in England were explored using national standardised tests. Multiple logistic regression was used to explore independent associates of NEC within the cohort. The authors obtained data for 119 (77%) of 157 children following proven or suspected NEC and compared their outcomes with those of the remaining 6496 children. NEC was associated with an increase in risk of neonatal death (OR 14.6 (95% CI 10.4 to 20.6)). At 7 years, NEC conferred an increased risk of all grades of impairment. Adjusting for confounders, risks persisted for any HUI-3 defined functional impairment (adjusted OR 1.55 (1.05, 2.29)), particularly mild impairment (adjusted OR 1.61 (1.03, 2.53)) both in all NEC children and in those with proven NEC, which appeared to be independent. No behavioural or educational associations were confirmed. Following NEC, children were more likely to suffer bowel problems than non-NEC children (adjusted OR 3.96 (2.06, 7.61)). The ORACLE Children Study provided opportunity for the largest evaluation of school age outcome following neonatal NEC and demonstrates significant long-term consequences of both gut function (presence of stoma, admission for bowel problems and continuing medical care for gut-related problems) and motor, sensory and cognitive outcomes as measured using HUI-3.

  18. The health and quality of life outcomes among youth and young adults with cerebral palsy.

    Science.gov (United States)

    Young, Nancy L; Rochon, Trista G; McCormick, Anna; Law, Mary; Wedge, John H; Fehlings, Darcy

    2010-01-01

    Young NL, Rochon TG, McCormick A, Law M, Wedge JH, Fehlings D. The health and quality of life outcomes among youth and young adults with cerebral palsy. To describe the health and quality of life (QoL) of youth and young adults who have cerebral palsy (CP), and to assess the impact of 3 key factors (severity, age, and sex) on these outcomes. Cross-sectional survey. Participants were identified from 6 children's treatment centers in Ontario. The sample of participants (N=199) included youth (n=129; age, 13-17y) and adults (n=70; age, 23-33y) with a broad range of severity: 35% mild, 19% moderate, and 47% severe. Not applicable. Health Utilities Index (HUI(3)), Assessment of Quality of Life (AQoL), and Self-Rated Health (SRH). SRH was reported to be excellent or very good by 57% of youth and 46% of adults. Mean HUI(3) scores were .30 for youth and .31 for adults. Mean AQoL scores were .28 for youth and adults. Severity of CP in childhood predicted 55% of the variance in HUI(3) scores and 45% of the variance in AQoL scores. Age and sex were not significant predictors of health or QoL. The observed health and QoL scores were much lower than those previously reported in the literature. This is likely a result of the inclusion of those with severe CP. The scores for youth were similar to those for adults and suggest that health and QoL outcomes were relatively stable across the transition to adulthood. Youth and adults with CP have limited health status and will require health care support throughout their lives to help them optimize their well being. Longitudinal follow-up studies are essential to understand better the patterns of health in this population over time. Copyright (c) 2010 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  19. Collaboration de chercheurs québécois et béninois contre le sida ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 oct. 2010 ... Au Bénin, il y a 20 ans, l'épidémie de VIH/sida faisait rage, et le pays manquait de tout pour l'endiguer. Aujourd'hui, la guerre au sida n'est pas encore terminée, mais de nombreux combats ont été gagnés. Et cela, entre autres, grâce à la ténacité de chercheurs comme Michel Alary, rattaché au Centre ...

  20. Proceedings of the International Congress/Actes du 6eme Congres International (6th) Held in Nice, France on 5-9 July 1993: Noise as a Public Health Problem. Volume 3

    Science.gov (United States)

    1993-07-09

    connus dans le milieu du travail, les effets extra-auditifs, ceux qui nous intdressent aujourd’hui au premier chef , sont des effets qui apparaissent A...ne semble pas trop affectd par cc genre de charabia et d𔄀vidences, bien que des exc~s apparaissent de temps 4 autre. Ainsi, de nombreux chefs ...5). Some of the details are described in companion papers (Refs 6-9); this paper describes the study in broad terms. The main objective of the new

  1. Algues unicellulaires marines : composition et prospectives.- Xèmes journées européennes de cosmétologie : Produits marins et plantes en thérapeutique et cosmétologie, 27, 28 et 29 janvier 1986

    OpenAIRE

    Lassus, Patrick

    1986-01-01

    Le développement croissant des cultures intensives d'algues unicellulaires marines pour l'aquaculture pose aujourd'hui le problème non seulement de la valeur nutritive de ces organismes mais également des ouvertures possibles vers un marché plus spécialisé en pharmacologie et cosmétologie. En effet, tant au niveau des propriétés étonnantes de certains produits d'excrétions (hydrates de carbone, biotoxines, antibiotiques) que des constituants de base (en particulier lipides et aminoacides) ...

  2. Evaluation de la qualité de vie des personnes vivant avec le VIH à ...

    African Journals Online (AJOL)

    Contexte: Lorsqu'en 2000 le Cameroun fait le choix du traitement par antirétroviraux pour les PVVIH, la qualité de vie (QdV) n'est pas un enjeu de la prise en charge. La chronicisation du sida place aujourd'hui l'évaluation de qualité de vie des PVVIH au sein des défis de santé publique. L'objectif de cette étude était ...

  3. Les traces matérielles de la Carte du Ciel. Le cas des observatoires d'Alger et de Bordeaux.

    Science.gov (United States)

    Le Guet Tully, F.; Davoigneau, J.; Lamy, J.; de La Noë, J.; Rousseau, J.-M.; Sadsaoud, H.

    2008-06-01

    Le chapitre évoque les traces matérielles de la Carte du ciel subsistant dans les observatoires d'Alger et de Bordeaux. Les auteurs examinent d'abord l'opération d'inventaire du patrimoine astronomique entreprise à partir du milieu des années 1990. Ils examinent ensuite les éléments concrets constituant aujourd'hui le patrimoine de la Carte du Ciel : lunettes, abris, accessoires, laboratoires, réseaux, plaques de verre, registres, machines à mesurer les clichés, et cartes.

  4. ICONOMANIA

    OpenAIRE

    Ruffino, Paolo

    2017-01-01

    FRENCH L’exposition IconoMania questionne l’image d’aujourd’hui, ses formes et ses symboliques, à travers le champ expérimental des nouvelles technologies. Dans cette relation « art et science », l’exposition s’intéresse aux problématiques de transformation (innovation et information), de transmission (communication et médias), et de représentation (sociale individuelle et collective). Près de seize oeuvres seront exposées sous la verrière d'un ancien bâtiment industriel du XIXème au co...

  5. La vague déferlante du soja brésilien

    OpenAIRE

    Théry , Hervé

    2004-01-01

    http://mappemonde.mgm.fr/num2/articles; International audience; The Brazilian soybean production, which is amongst the first three in the world, moved more than 1 300 miles northwards in thirty years, causing serious difficulties to export the harvests.; La production de soja brésilienne, une des trois premières mondiales, s'est déplacée en trente ans de plus de 2 000 kilomètres vers le nord, ce qui pose aujourd'hui de sérieux problèmes d'écoulement de la récolte.

  6. CARLSON WAGONLIT

    CERN Multimedia

    CARLSON WAGONLIT

    2010-01-01

    BESOIN D'IDEES CADEAUX ? OFFREZ L'EVASION DANS UN BOX ! Des weekends à deux ou en famille et pour tous les goûts: escapades gourmandes, aventures/randonnées, sensations, séjours pittoresques, maisons d’hôte ou châteaux prestigieux, forfaits beauté & séjours bien-être … Les SMARTBOX sont dès aujourd’hui en vente dans notre agence de voyages ! Nos agents tourisme sont à votre disposition pour tous renseignements au 72 797 ou par email cern@carlsonwagonlit.ch Au plaisir de vous revoir dans notre agence.

  7. Le projet de développement au service de la sécurité alimentaire des consommateurs : pour une approche territoriale

    OpenAIRE

    Brégeot, Ghislain; Chéneau-Loquay, Annie

    2013-01-01

    6 pages; International audience; Aujourd'hui, une grande partie des interventions réalisées par les acteurs étrangers (ONG et autres acteurs associatifs, Organisations internationales, Coopérations bilatérales, collectivités territoriales) dans les pays en développement est réalisée sous forme d'aide à projet. Or, la mise en place de ces projets ne prend pas toujours en compte les objectifs "annexes" de lutte contre la pauvreté ou la sécurité alimentaire.

  8. 1648-IJBCS-Article-Dedjiho Comlam Achille

    African Journals Online (AJOL)

    hp

    l'appauvrissement de la diversité spécifique. (Dupré, 2002), provoquant donc un déséquilibre de la chaîne trophique d'un plan d'eau et peut entraîner des conséquences écologiques importantes. Ce phénomène est devenu aujourd'hui un problème environnemental généralisé. Dans lacs artificiels de Yamoussoukro (Côte.

  9. The Indonesian Reader. History, Culture, Politics, Tineke Hellwig & Eric Tagliacozzo (eds

    Directory of Open Access Journals (Sweden)

    Laurence Husson

    2010-12-01

    Full Text Available Ce livre s’adresse à toute personne désireuse de comprendre comment s’est construite l’Indonésie, pourquoi elle est ce qu’elle est aujourd’hui et ce vers quoi elle tend. Il est d’ailleurs regrettable que ce pays fasse trop souvent la une des journaux à l’occasion de catastrophes naturelles ou humaines (tremblements de terre, tsunami, éruptions volcaniques, coulées de boues, inondations, feux de forêts, épidémie de grippe aviaire, crashs aériens, attentats meurtriers, etc. alors que globaleme...

  10. Combustion of Solid Propellants (La Combustion des Propergols Solides)

    Science.gov (United States)

    1991-07-01

    the of ether and ethyl alcohol and removing objective of these lectures to give a this solvent. Instead of having a fibrous comprehensive understanding...do cetto esrne do Les propergols composites, A matrice confifrences une description tout A fait A polymarique charg~o pst, un oxydant at un jour des...rusa., De nouveaux souvant suppos6 qua la vitesa des gaz de oxydes de for ultrafirts mont aujourd’hui combustion est n~gligeable at qua d~velopps pour

  11. Patient-reported outcome 2 years after lung transplantation: does the underlying diagnosis matter?

    Directory of Open Access Journals (Sweden)

    Ghosh S

    2012-11-01

    Full Text Available Maria Jose Santana,1 David Feeny,2 Sunita Ghosh,3 Dale C Lien41Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; 2Kaiser Permanente Center for Health Research, Portland, OR, USA; 3Cross Cancer Center, University of Alberta, Edmonton, Alberta, Canada; 4University of Alberta Hospital, Edmonton, Alberta, CanadaPurpose: Transplantation has the potential to produce profound effects on survival and health-related quality of life (HRQL. The inclusion of the patient’s perspective may play an important role in the assessment of the effectiveness of lung transplantation. Patient perspectives are assessed by patient-reported outcome measures, including HRQL measures. We describe how patients’ HRQL among different diagnosis groups can be used by clinicians to monitor and evaluate the outcomes associated with transplantation.Methods: Consecutive lung transplant recipients attending the lung transplant outpatient clinic in a tertiary institution completed the 15-item Health Utilities Index (HUI questionnaire on a touchscreen computer. The results were available to clinicians at every patient visit. The HUI3 covers a range of severity and comorbidities in eight dimensions of health status. Overall HUI3 scores are on a scale in which dead = 0.00 and perfect health = 1.00; disability categories range from no disability = 1 to severe disability <0.70. Single-attribute and overall HUI3 scores were used to compare patients’ HRQL among different diagnosis groups. Random-effect models with time since transplant as a random variable and age, gender, underlying diagnoses, infections, and broncholitis obliterans syndrome as fixed variables were built to identify determinants of health status at 2-years posttransplantation.Results: Two hundred and fourteen lung transplant recipients of whom 61% were male with a mean age of 52 (19–75 years were included in the study. Chronic obstructive pulmonary disease and cystic fibrosis patients displayed

  12. Juliette Pattinson, Behind Enemy Lines: Gender, Passing and the Special Operations Executive in the Second World War

    OpenAIRE

    Capet, Antoine

    2016-01-01

    Les crécibistes qui s’intéressent au domaine baptisé War Studies (à ne pas confondre avec Military History, à la fois plus facile à saisir et plus aisé à traduire) savent qu’il est en pleine expansion dans les universités britanniques. Autrefois, le King’s College de Londres en avait le quasi monopole. Aujourd’hui, il existe des centres très actifs à Birmingham, Édimbourg et Glasgow. Indirectement, également, des dépôts d’archive comme Mass Observation à Brighton et des groupes de recherche d...

  13. Les Machines pour le Big Data : Vers une Informatique Quantique et Cognitive.

    OpenAIRE

    Teboul , Bruno; Amri , Taoufik

    2014-01-01

    Cet article est une analyse prospective sur les mutations technologiques qui affecteront l’informatique et ses machines dans un avenir proche afin de répondre aux grands défis soulevés par notre société du tout digital. Nous pensons que ces mutations seront à la fois « quantique » et « cognitive ». Nous étayerons notre analyse en revenant sur ce qui fonde encore aujourd’hui nos ordinateurs, à savoir une architecture vieille de plus d’un demi-siècle, qui est responsable des espoirs déchus de l...

  14. Exploring the experiences of older Chinese adults with comorbidities including diabetes: surmounting these challenges in order to live a normal life

    OpenAIRE

    Ho, Hsiu-Yu; Chen, Mei-Hui; Lou, Meei-Fang

    2018-01-01

    Hsiu-Yu Ho,1,2 Mei-Hui Chen,2,3 Meei-Fang Lou1 1School of Nursing, College of Medicine, National Taiwan University, 2Department of Nursing, Yuanpei University of Medical Technology, 3National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, Republic of China Background: Many people with diabetes have comorbidities, even multimorbidities, which have a far-reaching impact on the older adults, their family, and society. However, little is known of the experience of older adult...

  15. Amal comme l'espoir : Une coopérative d'huile d'argan a changé la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    1 nov. 2010 ... Ma vie a changé. J'étais condamnée à ne jamais sortir de la maison. Aujourd'hui, je gagne de l'argent et je peux envoyer mes enfants à l'école. » Ainsi parle une femme qui est revenue à la vie grâce à la coopérative exclusivement féminine de Tamanar. Dans la région d'Essaouira au Maroc, une ...

  16. Reporting guidelines for diagnostic accuracy studies that use Bayesian latent class models (STARD-BLCM)

    DEFF Research Database (Denmark)

    Kostoulas, Polychronis; Nielsen, Søren S.; Branscum, Adam J.

    2017-01-01

    of disease status (i.e., disease status is a latent variable). Statistical methods were introduced in this context by Hui and Walter and have been succesfully applied since then, with the majority of the work being carried out in a Bayesian framework. While STARD provides useful reporting guidelines...... for studies designed to estimate the accuracy of tests when disease status is known. The original STARD statement was initially published in seven journals, while an updated version — STARD2015 — has been recently released. More than 200 biomedical journals encourage its use in their instructions to authors...

  17. Hacking interdit découvrez les techniques des hackers pour mieux vous protéger

    CERN Document Server

    Gomez-Urbina, Alexandre

    2010-01-01

    Aujourd'hui, impossible de surfer sur Internet sans protection efficace ! Mais même avec des logiciels appropriés, nul n'est à l'abri du danger ! Virus, usurpations d'adresse IP, troyens, intrusions dans votre système, attaques par phishing : l'imagination des pirates est sans limite ! La seule solution est de vous protéger efficacement et pour cela, un moyen : connaître les techniques des hackers pour mieux déjouer leurs pièges ! Un internaute averti en vaut deux !

  18. AHP 21: Who is to Blame?

    Directory of Open Access Journals (Sweden)

    Klu rgyal 'bum ཀླུ་རྒྱལ་འབུམ།

    2012-12-01

    Full Text Available I was born in a rural village of Hualong Hui Autonomous County, Qinghai Province. I graduated from Qinghai Normal University in 2011 with a BA in English. The summer afternoon sun beat down so harshly that everyone underneath felt they were being boiled in a pot. That the sun's heat was destroying the annual crops was a universal complaint, though everyone knew muttering was futile. Only when clouds appeared would anything change. In time, everyone went about their business and complained about the heat less... ...

  19. Retour "écologique" sur la question des nitrates

    OpenAIRE

    Buson, Christian

    2012-01-01

    Un examen critique de la question des nitrates est proposé dans cet article, à la lumière des connaissances disponibles dans différentes disciplines. Au plan sanitaire, la norme sur l’eau potable établie depuis plusieurs décennies résulte d’une erreur ancienne aujourd’hui reconnue comme telle. Les nitrates n’engendrent aucun trouble sanitaire et les griefs tels que la méthémoglobinémie du nourrisson, ou le risque de cancer du à la formation de nitrosamines, qui les ont...

  20. Malnutrition et politiques agro-alimentaires en Bolivie

    OpenAIRE

    Franqueville, André; Laure, Joseph

    1988-01-01

    Sutout connue en Europe pour son instabilité politique, ses coups d'Etat incessants et, aujourd'hui, pour sa culture de la coca, la Bolivie est aussi, on le sait moins, le pays le plus pauvre d'Amérique du Sud comme en témoignent tous les indicateurs socio-économiques disponibles. Mais la malnutrition qui sévit dans ce pays et qui semble bien en voie d'aggravation, n'est nullement le produit d'une nature particulièrement ingrate, car Altiplano, Vallées et Oriente pourraient heureusement combi...

  1. Watershed : The Role of Fresh Water in the Israeli-Palestinian Conflict

    International Development Research Centre (IDRC) Digital Library (Canada)

    Watershed décrit la crise de l'eau à laquelle font face aujourd'hui Israël et les Territoires occupés de la Palestine – crise qui aura beaucoup d'effet sur la conception et la réussite des propositions de paix en cours. Les auteurs analysent la géopolitique de l'eau dans la région, l'importance économique, les problèmes ...

  2. Les interventions de santé maternelle et infantile : vers une meilleure prise en compte des besoins des populations en Afrique

    OpenAIRE

    Gautier, Lara; Moshabela, Mosa; De Allegri, Manuela

    2017-01-01

    International audience; Aujourd’hui, il est fréquent de lire qu’en santé mondiale, la question n’est plus de savoir ce qui fonctionne bien, mais de comprendre comment et pourquoi les interventions réussissent ou se soldent par un échec (De Chesnay et Anderson, 2015). Ce chapitre, qui expose l’état des connaissances sur les interventions en santé maternelle, néonatale et infantile dans neuf pays d’Afrique subsaharienne révèle toute la pertinence de cette phrase.En 2014, une recension des écrit...

  3. Ramas, familles, réseaux. Les supports sociaux de la diffusion de la santería cubaine (Cuba-Mexique)

    OpenAIRE

    Argyriadis, Kali

    2014-01-01

    Ramas, familles, réseaux. Les supports sociaux de la diffusion de la santería cubaine (Cuba-Mexique). La santería cubaine participe d’un processus de transnationalisation qui concerne l’ensemble des religions dites afro-américaines, présentes aujourd’hui en Afrique de l’Ouest, en Europe et sur tout le continent américain. Pour parvenir à cerner cet objet dans son ampleur, l’approche en termes de réseau semble a priori la plus opératoire. L’enquête ethnographique, quand elle concentre son atte...

  4. De columbine à virgínia tech: reflexões com base empírica sobre um fenômeno em expansão

    OpenAIRE

    Vieira,Timoteo Madaleno; Mendes,Francisco Dyonísio Cardoso; Guimarães,Leonardo Conceição

    2009-01-01

    O fenômeno conhecido como school shooting vem chamando a atenção do mundo, principalmente após a tragédia na Columbine High School, na cidade de Littleton, Colorado, nos Estados Unidos, em 1999. Posteriormente, em abril de 2007, o estudante Cho Seung-Hui protagonizou um massacre de proporções ainda maiores ao atirar contra estudantes do Virginia Polytechnic Institute and State University, matando 32 pessoas e se suicidando ao final. O presente artigo reflete sobre o fenômeno chamando a atençã...

  5. From columbine to virgínia tech: empirical based reflections about an expanding phenomenon

    OpenAIRE

    Vieira, Timoteo Madaleno; Mendes, Francisco Dyonísio Cardoso; Guimarães, Leonardo Conceição

    2009-01-01

    O fenômeno conhecido como school shooting vem chamando a atenção do mundo, principalmente após a tragédia na Columbine High School, na cidade de Littleton, Colorado, nos Estados Unidos, em 1999. Posteriormente, em abril de 2007, o estudante Cho Seung-Hui protagonizou um massacre de proporções ainda maiores ao atirar contra estudantes do Virginia Polytechnic Institute and State University, matando 32 pessoas e se suicidando ao final. O presente artigo reflete sobre o fenômeno chamando a atençã...

  6. Aide à la décision en agriculture et gestion des ressources naturelles : note introductive

    OpenAIRE

    Jallas , Eric; Crétenet , Michel

    2003-01-01

    International audience; L'aide à la décision n'a pas pour but de se substituer aux décideurs en leur proposant des solutions "toutes faites". Elle cherche plutôt à les éclairer et à les guider vers des décisions dont ils conservent la responsabilité. Dans le domaine agricole et dans celui de la gestion des ressources naturelles, il existe aujourd'hui de nombreux outils d'aide à la décision. Les systèmes experts utilisent une base de connaissances afin de fournir des solutions, équivalentes à ...

  7. Les origines de la philosophie analytique de la religion

    Directory of Open Access Journals (Sweden)

    Nicholas Wolterstorff

    2012-07-01

    Full Text Available Il y a soixante ans, il y avait peu de philosophie de la religion et à peu près rien en ce qui concerne la théologie philosophique ; aujourd’hui, la philosophie de la religion en général, et la théologie philosophique en particulier, prospèrent dans la tradition analytique de la philosophie. Mon but est d’expliquer pourquoi la situation actuelle est si différente de celle d’il y a soixante ans.

  8. Regards croisés d'un physicien et d'un dessinateur sur Einstein et la physique the recipe of the Universe

    CERN Multimedia

    CERN. Geneva

    2006-01-01

    Rencontre donnée par John Ellis et Fiami. Partez à la découverte de la physique avec un auteur de bande dessinée qui vous fera découvrir six étapes cruciales de l’histoire de la connaissance, en compagnie de son héros Albert Einstein. Après ce voyage littéraire, un physicien du CERN vous expliquera les enjeux de la physique aujourd’hui, plus de 100 ans après Einstein.

  9. Essai de caractérisation des phénomènes de stalking dans un contexte juridique et politique : radiogoniométrie et filature On characterization of stalking phenomena in a juridical and political context: radiogoniometry and tracking

    OpenAIRE

    Desurmont N.

    2010-01-01

    De nos jours il est devenu impossible d’étudier les filatures comme on les pratiquait avant la naissance de la triangulation et de la radiogoniométrie, les observations satellitaires, les communications radios, etc. En effet l’usage de la radiogoniométrie et de d’autres techniques par les services des renseignements généraux et les forces de l’ordre biaisent aujourd’hui fortement l’analyse des filatures de ces organes en ayant recours qu’à l’analyse topologique et la géocriminologie. Le prése...

  10. Loisir, tourisme et développement durable

    OpenAIRE

    Chazaud, Pierre

    2016-01-01

    Cet ouvrage coordonné par Olivier Bessy s’inscrit dans la structuration en cours d’un courant de recherche autour de la socio-géographie du sport, des loisirs et du tourisme, en envisageant l’impact de ces pratiques en matière de construction et de développement territorial. L’ensemble des contributions essaient de montrer comment aujourd’hui des territoires aussi différents que les territoires montagnards, océaniques, ruraux, en friche et insulaires, sont structurés, mis en valeur et dynamis...

  11. Tourisme durable en zone de montagne : définition et enjeux

    OpenAIRE

    ZEGHNI, Sylvain

    2014-01-01

    La montagne est depuis longtemps un territoire de tourisme. Paradoxalement, pendant longtemps, la France a connu un déficit d'exploitation touristique hivernale de son massif. Les plans neige des années 60 et 70 eurent pour ambition de rattraper ce retard et de faire de notre pays la première destination de sport d'hiver. Cette ambition ayant été atteinte, le tourisme hivernal en zone de montagne est aujourd'hui un puissant levier économique d'aménagement et de développement. Il n'en reste pa...

  12. Méditations autour de Socrate

    OpenAIRE

    Bergeron, Jean-François

    2017-01-01

    Socrate, aujourd’hui. Quelle pertinence ? Quelle utilité ? Que nous enseignerait-il ? De quoi nous libérerait-il ? Où nous mènerait-il ? Répondre à ces questions, indubitablement, c’est refaire le procès de Socrate, donner notre jugement sur ce dernier. Remarquons que, jour après jour, notre monde serait très près de condamner, comme les Athéniens de l’époque, le philosophe. Alors que nous nous imaginerions une distance infinie entre les contempteurs de Socrate et nous, notre parenté en est p...

  13. Das Erbe der Menschheit.

    OpenAIRE

    Joana Breidenbach; Pál Nyíri

    2005-01-01

    Le concept d’« héritage » est apparu avec les efforts des États-nations occidentaux modernes émergents, au 19 e siècle, pour apporter une signification nationale à leurs paysages et à leurs environnements construits. Aujourd’hui, cependant, certains des moteurs centraux de ce mouvement de l’héritage sont des acteurs globaux plutôt que nationaux. Le projet le plus prestigieux pour la promotion de l’idée d’« héritage global » est la liste de l’Héritage mondial de l’ Unesco . Que deviennent les ...

  14. Transformée de Fourier applications en RMN et IRM

    CERN Document Server

    Verdun, Francis R

    1995-01-01

    Les méthodes spectroscopiques de Résonance Magnétique Nucléaire et l'Imagerie par Résonance Magnétique ont aujourd'hui largement dépassé le seul cadre du laboratoire. Un nombre croissant de personnes est confronté à leur utilisation ou à l'interprétation des résultats délivrés. Or les interfaces entre l'appareil et l'utilisateur font appel à un traitement mathématique sophistiqué qu'il est souhaitable de comprendre.

  15. .net

    Directory of Open Access Journals (Sweden)

    Le Comité de Rédaction d' EspacesTemps.net

    2002-06-01

    Full Text Available EspacesTemps lance aujourd'hui deux objets différents : un site internet et, sur ce site, Le Journal . Il s'agit donc de bien plus, et, au fond, de tout autre chose qu'un simple outil de communication destiné à informer nos lecteurs de nos parutions. Ce n'est pas non plus la « mise en ligne » de nos numéros-papier. L'internet nous donne au contraire l'occasion de réaliser, dans de meilleures conditions, ce que nous avons tenté de faire depuis quelques ...

  16. Cas pratique : Restauration écologique de la dépression humide de Kerminihy (Erdeven, Morbihan : une collaboration efficace entre propriétaire, gestionnaire et scientifiques

    Directory of Open Access Journals (Sweden)

    ÉLOUARD, Emmanuelle

    2011-05-01

    Full Text Available Travailler aujourd’hui en faveur de la restauration et de la préservation des zones humides, c’est pérenniser l’utilisation des ressources et des services qui s’y rapportent. Voici comment l’expérience réussie du programme d’actions de restauration écologique de la zone humide de Kerminihy, fruit d’une collaboration efficace entre propriétaire, gestionnaire et scientifiques, a favorisé le maintien d’une richesse écologique à forte valeur patrimoniale.

  17. Organisation spatiale de l'île de Ténériffe

    Directory of Open Access Journals (Sweden)

    Erwann Jadé

    2000-12-01

    Full Text Available Ténériffe, archipel des Canaries, îles Fortunées ou Bienheureuses. Fragment d'Europe exilé au large de l'Afrique, aujourd'hui espace de récréation pour urbains stressés du quotidien. Une île qui présente de multiples facettes. Combien de Ténériffe? L'organisation de l'espace insulaire illustre un cas de ségrégation spatiale liée au tourisme.

  18. Photo-souvenir sur assiette.

    Directory of Open Access Journals (Sweden)

    Blandine Ripert

    2004-09-01

    Full Text Available Nous sommes à Ayuthaya, ancienne capitale du Siam qui tomba en 1767 après l’invasion birmane, ne laissant derrière elle que ruines de cette grande ville marchande qui attirait les commerçants de toute l’Asie mais aussi les Européens présents en Orient. Seuls les temples, bouddhistes, sont restés debout et ont traversé les siècles, attirant aujourd’hui de très nombreux touristes qui font fleurir un commerce tout aussi international qu’auparavant. Cet étal mobile propose au ...

  19. Constructing Singapore : Elitism, Ethnicity and the Nation-Building Project, Michael D. Barr & Zlatko Skrbis

    Directory of Open Access Journals (Sweden)

    Jean-Louis Margolin

    2010-12-01

    Full Text Available Michael Barr, seul ou en collaboration, est depuis une décennie l’un des auteurs les plus prolifiques et les plus reconnus sur la structuration politique et sociologique du Singapour contemporain. Longtemps attaché à l’université du Queensland (Brisbane, aujourd’hui à Flinders (Adelaide, il est assez représentatif de la nouvelle génération (singapourienne aussi bien qu’étrangère des spécialistes de la cité-état : fermement critique, et parfois même hyper-critique, elle n’en reconnaît pas m...

  20. Maintenir la continuité des collections à l'heure d'Internet : du catalogue de vente au site web de maison de vente

    OpenAIRE

    Jacquet , Françoise

    2014-01-01

    International audience; La Bibliothèque nationale de France conserve depuis des siècles une importante collection de catalogues de vente sur support papier. Cependant avec l’apparition d’Internet on assiste à une dématérialisation des données documentaires en art. Aujourd’hui les sites des maisons de vente offrent en ligne les adjudications des ventes, récentes ou archivées et certaines ventes sont désormais annoncées uniquement sur Internet. Ces informations qui ne se trouvent pas sur les ca...

  1. Territorialisation et enclaves littorales dans les îles de la Caraïbe

    Directory of Open Access Journals (Sweden)

    Michel Desse

    2008-04-01

    Full Text Available Les littoraux de la Caraïbe ont longtemps été considérés comme des espaces de l’envers, ouverts, libres, propriété de l’Etat donc de tous, opposables à la plantation qui hiérarchise la société, structure le paysage et identifie la richesse.Aujourd’hui, les littoraux constituent les centres fonctionnels des îles, annexés parfois privatisés, ils apparaissent fortement territorialisés. Les facteurs qui expliquent ces transformations sont multiples. Les îles connaissent une forte tertiairisation ...

  2. Behavioral activation for dementia caregivers: scheduling pleasant events and enhancing communications

    OpenAIRE

    Au, Alma; Gallagher-Thompson, Dolores; Wong, Meng-Kong; Leung, Jess; Chan, Wai-Chi; Chan, Chun Chung; Lu, Hui-Jing; Lai, Man Kin; Chan, Kevin

    2015-01-01

    Alma Au,1,2 Dolores Gallagher-Thompson,3 Meng-Kong Wong,4 Jess Leung,4 Wai-Chi Chan,5 Chun Chung Chan,6 Hui-Jing Lu,1 Man Kin Lai,1 Kevin Chan11Department of Applied Social Sciences, 2Institute of Active Aging, The Hong Kong Polytechnic University, Hong Kong, People’s Republic of China; 3Department of Psychiatry and Behavioral Sciences and Geriatric Education Centre, School of Medicine, Stanford University, Stanford, CA, USA; 4Department of Psychiatry, United Christian Hosp...

  3. Introduction à MATLAB

    OpenAIRE

    Zenou, Emmanuel

    2013-01-01

    Cette initiation à MatLab a pour objectif de se familiariser à un outil très utilisé par la communauté scientifique dans les laboratoires et dans l'industrie. Il a également pour objectif d'initier (pour ceux qui n'y ont jamais touché) à la programmation et à l'algorithmique, ce qui est indispensable à tout bon ingénieur aujourd'hui. En effet, beaucoup de notions introduites ici ne sont pas propres à MatLab mais à tout langage structuré comme le C/C++, le Java, etc.

  4. LA FINANCE ISLAMIQUE, DES FONDEMENTS AU SYSTÈME

    OpenAIRE

    Fatima Zahra ALIOUI; Zeyneb GUELLIL; Soufyane BADRAOUI

    2015-01-01

    Force est de constater aujourd’hui, que la finance basée sur les préceptes de l’Islam, à savoir la finance islamique, remet violemment en cause notre conception de la finance et de l’économie. Cette nouvelle finance, pour certains, de «toutes les vertus«éthiques» et anti-crise», ou simple attirail marketing pour d’autres, a au moins le mérite de faire parler d’elle! Associé finance et Islam, c’est faire le postulat qu’il existe une relation entre économie et religio...

  5. TABLE OF CINTENTS and ABSTRACTS reprinted from ACTA PHYSICA SINICA,Vol.50,No.6(2001)(in Chinese)

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@0000 GENERAL 0330 Conservation Laws of Relativistic Variable Mass Systems…………………………… Fang Jian-hui (1005) 0340 Simulation of Shock Waves Using a Lattice Boltz mann Equation Model …………………… Feng Shi-de, Michihisa Tsutahara (1010) 0365 Double-Wave Function of RLC Circuit After Quantization…………………… Long Chao-yun, Liu Bo (1014) 0420 The Nernst Theorem and Statistical Entropy of the Scalar field in Reissner-Nordstrom Geometry……………………Zhao Ren, Zhang Li-chun (1018)

  6. Graphene energy storage and conversion applications

    CERN Document Server

    Liu, Zhaoping

    2014-01-01

    Series PrefacePrefaceAuthorsGraphene Overview; Xufeng Zhou, Wei Wang, and Zhaoping LiuSynthesis of Graphene; Wei Wang, Hailiang Cao, Xufeng Zhou, and Zhaoping LiuApplications of Graphene in Lithium Ion Batteries; Xufeng Zhou and Zhaoping LiuApplications of Graphene in New-Concept Batteries; Xufeng Zhou and Zhaoping LiuApplications of Graphene in Supercapacitors; Chao Zheng, Xufeng Zhou, Hailiang Cao, and Zhaoping LiuApplications of Graphene in Solar Cells; Fuqiang Huang, Dongyun Wan, Hui Bi, and Tianquan LinApplications of Graphene in Fuel Cells; Xuejun Zhou, Jinli Qiao, and Yuyu LiuIndex.

  7. Eléments de théorie des graphes

    CERN Document Server

    Bretto, Alain; Hennecart, François

    2012-01-01

    Ce livre est une introduction d velopp e la th orie des graphes. Autour de cette th orie se d veloppe aujourd'hui l'un des domaines les plus f conds et les plus dynamiques des mah matiques et de l'informatique. La th orie des graphes permet de r pr senter un ensemble complexe d'objets en exprimant les relations entre les l ments: r seaux de communication, circuits lectriques, etc. Le livre pr sente le langage et les notions l mentaires de cette th orie, les diff rents types de graphes (bipartis, arbres, arborescences, graphes eul riens et hamiltoniens, etc.); il tudie les relations entre les g

  8. Re-ranking via User Feedback: Georgetown University at TREC 2015 DD Track

    Science.gov (United States)

    2015-11-20

    Re-ranking via User Feedback: Georgetown University at TREC 2015 DD Track Jiyun Luo and Hui Yang Department of Computer Science, Georgetown...involved in a search process, the user and the search engine. In TREC DD , the user is modeled by a simulator, called “jig”. The jig and the search engine...simulating user is provided by TREC 2015 DD Track organizer, and is called “jig”. There are 118 search topics in total. For each search topic, a short

  9. W-Band Technology and Techniques for Analog Millimeter-Wave Photonics

    Science.gov (United States)

    2015-08-19

    Chang and C. Liu, “1-100 GHz microwave photonic link technologies for next- generation WiFi and 5G wireless communications,” in IEEE Topical Meeting on...high- speed optical transmission,” Opt. Exp., vol. 14, no. 9, pp. 3767-3775, Apr. 2006. [17] R. S. Tucker, G. Eisenstein, and S. K. Korotky...Sept. 1990. [20] R. Hui, B. Zhu, R. Huang, C. T. Allen, K. R. Demarest, and D. Richards, “Subcarrier multiplexing for high- speed optical transmission

  10. Sexospécificités | Page 233 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Aujourd'hui, je gagne de l'argent et je peux envoyer mes enfants à l'école. » Ainsi parle une femme qui est revenue à la vie grâce à la coopérative exclusivement féminine de Tamanar. Dans la région d'Essaouira au Maroc, une cinquantaine de femmes ont, grâce à un savoir-faire ancestral, allié gestes de grand-mère mille ...

  11. Sociolinguistic aspects of language change in kabiye-french code ...

    African Journals Online (AJOL)

    Ce phénomène peut s'expliquer par le fait que la réussite à l'école, et par conséquent dans la vie sociale, dépend de la maîtrise du Français. La présente étude montre qu'aujourd'hui, le 'code-switching' kabiyè et français est devenu le moyen de communication le plus courant non seulement entre les scolarisés, mais ...

  12. Non disponible / Not available

    OpenAIRE

    Sonia , Assili

    2014-01-01

    Non disponible / Not available; Dans de nombreux pays développés, les patients cherchent des alternatives auxsoins dentaires devenus difficiles d’accès pour de multiples raisons. Parallèlement, lamondialisation n’épargne aucun secteur, si bien que nous assistons à la commercialisation dela santé. Le patient tend à devenir un consommateur de soins et le praticien un délivreur desoins. L’offre de soins à l’étranger et aujourd’hui dans des centres dentaires dits « low-cost »apparaissent comme un...

  13. Agir sur le gaspillage alimentaire

    OpenAIRE

    Jan, Sophie; Baron, Florence

    2016-01-01

    On estime aujourd'hui à 25% les pertes d'aliments post-récolte et en aval, en raison de leur altération par des microorganismes. L'étude menée ici illustre le risque d'altération engendré par une rupture dans la chaîne du froid, en prenant comme modèle un aliment liquide pasteurisé et réfrigéré, riche en nutriments et dont la température ne doit pas dépasser 4°C.

  14. Entrepreneurs, État et citoyenneté.Le cas de la Tunisie

    OpenAIRE

    Nabli, Rabah

    2013-01-01

    Aujourd’hui, de nombreux observateurs et chercheurs vigilants s’accordent à affirmer le caractère non parasitaire des entrepreneurs tunisiens, quelle que soit leur région d’origine. Mais une question continue d’être posée: pourrons-nous aussi affirmer avec la même certitude qu’en dépit de leurs faiblesses structurelles, les entrepreneurs tunisiens et surtout les plus jeunes d’entre eux, sont en voie de se constituer en une force sociale disposant d’un poids politique leur permettant de dicter...

  15. Glarus - Blanchiment

    OpenAIRE

    Fluck , Pierre

    2008-01-01

    Cette usine se trouve dans la vallée du Strengenbach, à l'écart de la ville (23 établissements au cours des XVIIIème et XIXème siècles). On pratiquait autour de cet établissement le blanchiment sur prés. A l'origine, elle s'appellait Caspar Vogel. En 1850, elle devint David Pabst. En 1855, un incendie ravagea les bâtiments. Nouvelle construction en 1863, pour devenir en 1864 : Speich, Pabst & Streiff. En 1869, la raison sociale est Streiff & Cie. Aujourd'hui : Bleicherei Streiff AG.

  16. Report of the European Energy Law Seminar 2010

    International Nuclear Information System (INIS)

    Beukenkamp, J.F.M.; Webbink, F.J.; Fenijn, A.W.C.; Klapwijk, C.L.

    2010-01-01

    The Annual European Energy Law Seminar was held on 12 and 13 April 2010 at the Grand Hotel Huis ter Duin in Noordwijk, the Netherlands. This article reports on the meeting. The presentations held on the first day addressed various aspects of the Third Energy Package such as the issues of unbundling and third party access, the establishment of a European network of regulators, the collaboration of regulators and the ongoing market integration. Day 2 addressed security of supply and climate protection and the required investments. An overview is also provided of recent developments in the EU competition legislation. [nl

  17. Penser les métropoles pour les « individus » ?

    Directory of Open Access Journals (Sweden)

    Marc Dumont

    2006-03-01

    Full Text Available Les instruments dont on dispose aujourd’hui pour décrire et expliquer les réalités métropolitaines contemporaines ne sont pas entièrement satisfaisants : ils ne permettent pas toujours d’identifier les vraies questions qui se présentent à ceux qui produisent la ville. Partant de ce constat, le sociologue Alain Bourdin synthétise dans son nouvel essai des réflexions issues de sa pratique de recherche et de dialogue avec le monde des institutions, pour y proposer une lecture de la ...

  18. Taxonomic study of Festuca L. subgenus Schedonorus (P. Beauv. Peterm. in Iran

    Directory of Open Access Journals (Sweden)

    Sayed Zabihollah Hosseini

    2013-11-01

    Full Text Available This study was based upon a taxonomic review of the subgenus Schedonorus in Iran. A collection of 30 specimens belonging to the herbaria: W, B and HUI (herbarium of the University of Isfahan were studied. Based on the results of this study, this subgenus included three species: Festuca arundinacea, F. gigantea and F. pratensis in Iran. Furthermore, this study showed that F. arundinacea, occured in this country with two subspecies: orientalis (Hack. Tzvelev and fenas (Lag. Arcang. with the greatest area of distribution compared to the other two species. Our examination of the type specimen of F. elatior subsp. pratensis var. elbursiana confirmed its synonymy with F. arundinacea.

  19. L'univers créativité cosmique et créativité artistique

    CERN Document Server

    Reeves, Hubert; Champion, Claire

    2016-01-01

    Avec le talent de vulgarisateur qu'on lui connaît, Hubert Reeves explique, en faisant d'habiles parallèles avec la créativité humaine, ce que l'on sait aujourd'hui de la création de l'Univers. Avec ses mots et ses idées simples, épurées comme des haïkus, Hubert Reeves arrive à faire comprendre l'infiniment complexe, tout en amenant ses lecteurs au bord du gouffre métaphysique.

  20. Editorial

    Directory of Open Access Journals (Sweden)

    Muriel Verbeeck-Boutin

    2007-10-01

    Full Text Available Version françaisePorter un projet comme un enfant en soi : la métaphore est facile, sans doute. Et pourtant ! Quelle autre image employer, pour évoquer ces quelques mois tout entiers consacrés à mûrir une idée, à la concrétiser et la mettre en œuvre, jusqu’à sa parution, aujourd’hui. Neuf mois à éveiller des enthousiasmes (ou trouver des gens pour partager le mien, susciter des collaborations, nouer des partenariats, mettre en œuvre une structure, dessiner une image, écrire, relire, corriger...

  1. Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant

    OpenAIRE

    Zhao,JiHui; Zhang,Qi-Bo; Liu,Bao; Piao,Xiang-Hua; Yan,Yu-Lu; Hu,Xiao-Ge; Zhou,Kuan; Zhang,Yong-Tai; Feng,Nian-Ping

    2017-01-01

    Ji-Hui Zhao,1,* Qi-Bo Zhang,1,* Bao Liu,2 Xiang-Hua Piao,1 Yu-Lu Yan,1 Xiao-Ge Hu,1 Kuan Zhou,1 Yong-Tai Zhang,1 Nian-Ping Feng1 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Anethesiology Department, Augusta University, Augusta, GA, USA *These authors contributed equally to this work Purpose: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a ...

  2. Etat des lieux et perspectives du pin sylvestre en Wallonie

    OpenAIRE

    Thibaut, K.; Colson, Vincent; Lecomte, H.; Claessens, Hugues

    2007-01-01

    Si le pin sylvestre fut l’un des pionniers de la reforestation de nos contrées, l’engouement qu’il suscita au XIXe siècle semble aujourd’hui bien retombé. À travers l’analyse de la ressource disponible et d’une rapide enquête auprès des cantonnements de la DNF, l’article propose un état des lieux de cette essence et discute de ses perspectives dans le contexte actuel.

  3. Un « Nouvel hygiénisme » ? Le bruit, l’odeur et l’émergence d’une new middle class

    Directory of Open Access Journals (Sweden)

    Laurent Matthey

    2005-10-01

    Full Text Available La tentation est grande aujourd’hui d’envisager un « Nouvel hygiénisme » qui façonnerait les espaces urbains et les corps. Cet article défend cependant l’hypothèse que ce qu’il est convenu d’appeler « Nouvel hygiénisme » est en fait un ensemble de pratiques sociales qui reposent sur la consommation ostentatoire et la distinction sociologique d’une classe sociale en ascension (la new middle class.

  4. Aménageurs et «reconversion cartographique»

    Directory of Open Access Journals (Sweden)

    Patrick POTTIER

    1991-03-01

    Full Text Available Aménageurs et urbanistes s’accordent à faire des Systèmes de Gestion de Bases de Données Géographiques l’outil de demain. Pourtant, de réelles difficultés freinent aujourd’hui leur développement. Ces difficultés ne pourront être surmontées qu’en envisageant une réflexion profonde sur l’information géographique et l’analyse spatiale.

  5. Malnutrition and child health in rural Rwanda: management of community based growth monitoring.

    OpenAIRE

    Ngirabega, Jean de Dieu

    2010-01-01

    En l’an 2000, les Nations Unies ont adopté les Objectifs du Millénaire pour le Développement avec comme premier objectif l’éradication de l’extrême pauvreté et de la faim. La relation synergique entre une bonne nutrition et le développement économique est aujourd’hui indiscutable. La malnutrition et la pauvreté sont deux problèmes interdépendants et qui partagent les mêmes causes. On estimait en 2008 que le retard de croissance staturale affectait 195 millions d’enfants de moins de cinq ans d...

  6. People who live for quality

    International Nuclear Information System (INIS)

    1995-03-01

    This book introduces the case of model of quality management. There are a lot of titles and people's example such as with dogged perseverance by Kang, Beom Sik in SK industry, come back to company which he submitted his resignation by Kim, Byeong Hui in Hyundai Heavy industries, I want to be the world best by Yeon, Sang Jin in Geum Ho industry, a good beginning is half the battle by Kwon, Bok Sik in KIA company, employee satisfaction is quality management by Hong, Sun Gyeom, in Dong Yang piston, and praying for all by Kim, Youn Ja in Lotte department store.

  7. 2140-IJBCS-Article-Koffi Marcelin Yao

    African Journals Online (AJOL)

    hp

    Mots clés : Métaux traces, matière organique, adsorption, désorption, Estuaire. INTRODUCTION. La contamination de l'atmosphère, de l'hydrosphère et des sédiments par les métaux lourds est aujourd'hui très préoccupant pour les pays développés et émergents. Les métaux lourds sont des éléments métalliques dont la.

  8. 空间 、 身体 、女权: 中国都市女性写作

    OpenAIRE

    Chan (陈颖), Shelley

    2009-01-01

    Chinese women have been continuous hits in mass media throughout the past decade. While names such as Mian Mian and Wei Hui have caught the attention of readers with their fin de siècle decadent writings, or , “genital writingd” as labeled by some critics, Mu Zimei, Zhuying Qingtong and Sister Lotus have excited netizens with their online sex diaries, hawking details of one-night stands, nude self-portraits, and pictures of flirtatious gestures respectively, which have caused far greater dist...

  9. Sport et éthique: enjeux et outils pour le marketing sportif - Sport and ethics: stakes and tools for marketing of sport

    OpenAIRE

    Emmanuel Bayle; Samuel Mercier

    2008-01-01

    (VF)Dans un contexte général d’une demande sociétale d’éthique, d’appel à la responsabilité sociale des entreprises et face aux attaques (dopage, violences, corruption…) que connaît aujourd’hui le mythe de l’éthique sportive, comment les organisations présentes dans le secteur du sport adaptent-elles leurs stratégies marketing ? Cet article propose une typologie des enjeux stratégiques de l’instrumentalisation de l’éthique sportive selon quatre types d’organisations. A partir de ce cadre conc...

  10. La prospective Agrimonde : une tentative d'allier prospective et recherche en France et à l'international

    Directory of Open Access Journals (Sweden)

    de LATTRE-GASQUET, Marie

    2017-03-01

    Full Text Available Nourrir le monde aujourd’hui et en 2050 est un enjeu majeur, et la recherche agricole peut y contribuer. Elle doit pour cela anticiper les changements possibles, identifier les enjeux et de nouvelles questions de recherche, et la prospective permet de le faire. Cet article détaille le lancement, le déroulement et la diffusion d’un exercice de prospective, Agrimonde, et analyse à partir de cet exemple le rôle de la prospective pour la recherche.

  11. Etude linguistique chez les Baráshi/Banyaambo du Rwanda

    African Journals Online (AJOL)

    User

    ont quitté le Nkóle et ont gagné le Mutára, puis le Mubarí qui est une large bande frontalière située au nord du lac Ihema jouxtant la région tanzanienne de Karágwe. Puis le mouvement s'est poursuivi vers le sud, ce qui explique donc la présence aujourd'hui d'une communauté Baráshi/Banyaambo au. Gisaká autour des ...

  12. La désacidification biologique des vins. Etat de la question, perspectives d'avenir

    Directory of Open Access Journals (Sweden)

    Aline Lonvaud-Funel

    1994-06-01

    Sa maîtrise passe par l'utilisation de levains bactériens, dont les plus récents sont ensemencés directement au vin après la fermentation alcoolique. Les résultats des recherches fondamentales sur l'enzyme malolactique permettent aujourd'hui d'envisager la construction de réacteurs enzymatiques et sans doute plus rapidement, le transfert de cette activité enzymatique chez les levures de vinification.

  13. Vorinostat-eluting poly(DL-lactide-co-glycolide) nanofiber-coated stent for inhibition of cholangiocarcinoma cells

    OpenAIRE

    Kwak TW; Lee HL; Song YH; Kim C; Kim JS; Seo SJ; Jeong YI; Kang DH

    2017-01-01

    Tae Won Kwak,1,* Hye Lim Lee,2,* Yeon Hui Song,2 Chan Kim,3 Jungsoo Kim,2 Sol-Ji Seo,2 Young-Il Jeong,2 Dae Hwan Kang2,4 1Medical Convergence Textile Center, Gyeongbuk, Republic of Korea; 2Biomedical Research Institute, Pusan National University Hospital, Pusan, Republic of Korea; 3Amogreentech Co. Ltd. Gyeonggi-do, Republic of Korea; 4Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Gyeongnam, Republic of Korea *These auth...

  14. Dynamique des populations du foreur des tiges du cacaoyer ...

    African Journals Online (AJOL)

    Objectif : Le foreur de tiges du cacaoyer, Eulophonotus myrmeleon Felder cause aujourd'hui d'énormes dégâts dans les cacaoyères ivoiriennes. La présente étude vise à déterminer les périodes de fortes attaques de ce déprédateur dans la région du Haut-Sassandra, la deuxième plus grande région de production de ...

  15. Integrated Ideas of a Life Warrior ~ An Interview with Leo Fong

    Directory of Open Access Journals (Sweden)

    Peter Hobart

    2012-07-01

    Full Text Available Mr. Leo Fong is the architect and founder of a system of martial arts known as Wei Kuen Do (man. Hui Quan Dao—the Way of the Integrated Fist. Leo Fong trained in a variety of Chinese disciplines, including Shaolin, Choy Lay Fut and Tiger Claw, and was a close associate of Bruce Lee. Over the course of his studies, Master Fong combined many of the aspects of Chinese martial arts with principles of western boxing, to produce his own, unique and devastating system of self-defense.

  16. Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China.

    Science.gov (United States)

    Zhang, Suhua; Bian, Yingnan; Li, Li; Sun, Kuan; Wang, Zheng; Zhao, Qi; Zha, Lagabaiyila; Cai, Jifeng; Gao, Yuzhen; Ji, Chaoneng; Li, Chengtao

    2015-12-04

    As a multi-ethnic country, China has some indigenous population groups which vary in culture and social customs, perhaps as a result of geographic isolation and different traditions. However, upon close interactions and intermarriage, admixture of different gene pools among these ethnic groups may occur. In order to gain more insight on the genetic background of X-Chromosome from these ethnic groups, a set of X-markers (18 X-STRs and 16 X-Indels) was genotyped in 5 main ethnic groups of China (HAN, HUI, Uygur, Mongolian, Tibetan). Twenty-three private alleles were detected in HAN, Uygur, Tibetan and Mongolian. Significant differences (p population differentiation of HUI and Uygur. However, the HAN, Tibetan and Mongolian ethnic groups were closely clustered. Eighteen X-Indels exhibited in general congruent phylogenetic signal and similar cluster among the 5 ethnic groups compared with 16 X-STRs. Aforementioned results proved the genetic polymorphism and potential of the 34 X-markers in the 5 ethnic groups.

  17. Development of a High Sensitivity Digital Cerenkov Viewing Device. Prototype Digital Cerenkov Viewing Device. Field test in Sweden

    International Nuclear Information System (INIS)

    Chen, J.D.; Gerwing, A.F.; Lewis, P.D.; Larsson, M.; Jansson, K.; Lindberg, B.; Sundkvist, E.; Ohlsson, M.

    2002-05-01

    The Swedish and Canadian Safeguards Support Programs have developed a prototype Digital Cerenkov Viewing Device (DCVD) to verify long-cooled spent fuel. The instrument consists of a camera system and a custom portable computer equipped with a liquid crystal and a wearable heads-up display. The camera was coupled to a hardware user interface (HUI) and was operated with a computer program designed to image spent fuel and store the images. Measurements were taken at the CLAB facility on pressurized-water reactor fuel and non-fuel assemblies, a number of boiling-water reactor fuel assemblies, and long-cooled Aagesta fuel assemblies. The camera head, attached to the HUI, a battery-operated computer carried in a backpack and the heads-up display were field tested for portability. The ergonomics of this system is presented in the report. For the examination of long-cooled spent fuel, the camera head was mounted on a bracket that rested on the railing of a moving bridge. The DCVD instrument is approximately 100 times higher in sensitivity than the Mark IVe CVD. The oldest fuel with the lowest burnup at the CLAB facility was positively verified. The measurement capability of this instrument greatly exceeds the verification criteria of 10,000 MWd/t U and 40 years cooling

  18. Approche historiographique des pratiques sportives au Cameroun

    Directory of Open Access Journals (Sweden)

    Biwole M. Claude Emmanuel Abolo

    2016-01-01

    En 50 ans d'indépendance, le sport camerounais a beaucoup évolué. De 11 en 1970, les fédérations sportives sont passées à plus de 40 aujourd'hui et les titres, trophées et médailles ne se comptent plus depuis lors. Le Cameroun est devenu progressivement une nation où le sport compte et où l'exploit sportif n'est plus méprisé, rejeté, voire vilipendé. Hier assimilés à des brutes épaisses, les sportifs sont aujourd'hui admirés et adulés. Finie l'image négative de marginaux qui leur collait au corps : finis les sous-entendus ridicules où ils étaient classés au bas de l'échelle sociale, juste bons pour bander les muscles et réaliser des performances. C'est cela la plus grande victoire du sport camerounais en 50 ans d'existence. Il a réussi à faire l'unanimité et les performances des sportifs devenues pour toute la nation un modèle, une référence et un réel motif de fierté.

  19. Survey on risk perception of radiation following an incident involving a stuck 60Co source in Henan Province, China

    International Nuclear Information System (INIS)

    Lei, C.; Sun, Q.; Cheng, X.; Zhang, Q.; Fu, Y.; Chu, C.; Zhao, Y.; Qin, W.; Su, X.

    2012-01-01

    In July 2009, an incident involving a stuck Co-60 source led hundreds of thousands of people to escape Qi County, Henan Province, China, although no medical or environmental consequences were related to the incident. To investigate knowledge about radiation, public risk-perception of radiation, and evaluation of the official response, a survey was conducted in Qi and Hui County (control). Face-to-face questionnaire interviews were conducted among three groups with different educational backgrounds. In total, 1340 valid questionnaires were collected from people interviewed. Knowledge about radiation was low in all groups in both counties, although knowledge in Qi County was higher than that in Hui County (control). More than 40 % respondents supported construction of nuclear power plants (NPPs) in China, while only a few supported constructing NPPs in their vicinity. The main reasons for the mass escape following the incident were assumed to be lack of knowledge about radiation, misinformation, the government's failure to disclose information in time and imitation of group behaviour. Over 60 % in Group I and II trusted the local government. About 64 % disapproved the response of the Qi County government. After the incident, the population in Qi County still knows little about radiation. Although people trust the government, they are dissatisfied with the response of the local government regarding the incident. (authors)

  20. Taiwan: um futuro formoso para a Ilha? Aspectos de segurança e política

    Directory of Open Access Journals (Sweden)

    Paulo A. Pereira Pinto

    2004-12-01

    Full Text Available A partir de declaração de Lee Teng-Hui, em 1999, de que existe "um Estado em cada margem do estreito", foi estabelecida nova cena de partida que dificulta a realização de um futuro formoso para a ilha de Taiwan. Em março de 2004, por ocasião de eleições para renovar sua liderança, os taiwaneses defrontaram-se com problemas de segurança e políticos, influenciados por poderosas forças externas, que contribuem para o clima de incerteza que se vive. Parece difícil crer que autoridades em Taipé sejam capazes do engenho e arte de exercitar a ambigüidade necessária para manter o "status quo".Lee Teng-Hui's 1999 statement that there is "one State on each side of the strait" established a new starting point that makes difficult the achievement of a rosy future for the island of Taiwan. In March 2004, as elections for renewing their leadership were taking place, the Taiwanese were confronted with security and political problems that were influenced by powerful external forces, which intensified the prevailing uncertainty. It seems difficult to believe that the authorities in Taipei possess the skill and the art for practicing the requisite ambiguity for maintaining the status quo on the island.