WorldWideScience

Sample records for huge search space

  1. Huge Casimir effect at finite temperature in electromagnetic Rindler space

    CERN Document Server

    Zhao, Tian-Ming

    2011-01-01

    We investigate the Casimir effect at finite temperature in electromagnetic Rindler space, and find the Casimir energy is proportional to $\\frac{T^4}{d^2}$ in the high temperature limit, where $T\\approx 27 ^\\circ\\mathrm{C}$ is the temperature and $d\\approx 100nm$ is a small cutoff. We propose to make metamaterials to mimic Rindler space and measure the predicted Casimir effect. Since the parameters of metamaterials we proposed are quite simple, this experiment would be easily implemented in laboratory.

  2. Huge Casimir effect at finite temperature in electromagnetic Rindler space

    Science.gov (United States)

    Zhao, Tian-Ming; Miao, Rong-Xin

    2011-12-01

    We investigate the Casimir effect at finite temperature in electromagnetic Rindler space, and find the Casimir energy is proportional to $\\frac{T^4}{d^2}$ in the high temperature limit, where $T\\approx 27 ^\\circ\\mathrm{C}$ is the temperature and $d\\approx 100nm$ is a small cutoff. We propose to make metamaterials to mimic Rindler space and measure the predicted Casimir effect. Since the parameters of metamaterials we proposed are quite simple, this experiment would be easily implemented in laboratory.

  3. Huge Casimir effect at finite temperature in electromagnetic Rindler space

    OpenAIRE

    Zhao, Tian-Ming; Miao, Rong-Xin

    2011-01-01

    We investigate the Casimir effect at finite temperature in electromagnetic Rindler space, and find the Casimir energy is proportional to $\\frac{T^4}{d^2}$ in the high temperature limit, where $T\\approx 27 ^\\circ\\mathrm{C}$ is the temperature and $d\\approx 100nm$ is a small cutoff. We propose to make metamaterials to mimic Rindler space and measure the predicted Casimir effect. Since the parameters of metamaterials we proposed are quite simple, this experiment would be easily implemented in la...

  4. Searching Fragment Spaces with feature trees.

    Science.gov (United States)

    Lessel, Uta; Wellenzohn, Bernd; Lilienthal, Markus; Claussen, Holger

    2009-02-01

    Virtual combinatorial chemistry easily produces billions of compounds, for which conventional virtual screening cannot be performed even with the fastest methods available. An efficient solution for such a scenario is the generation of Fragment Spaces, which encode huge numbers of virtual compounds by their fragments/reagents and rules of how to combine them. Similarity-based searches can be performed in such spaces without ever fully enumerating all virtual products. Here we describe the generation of a huge Fragment Space encoding about 5 * 10(11) compounds based on established in-house synthesis protocols for combinatorial libraries, i.e., we encode practically evaluated combinatorial chemistry protocols in a machine readable form, rendering them accessible to in silico search methods. We show how such searches in this Fragment Space can be integrated as a first step in an overall workflow. It reduces the extremely huge number of virtual products by several orders of magnitude so that the resulting list of molecules becomes more manageable for further more elaborated and time-consuming analysis steps. Results of a case study are presented and discussed, which lead to some general conclusions for an efficient expansion of the chemical space to be screened in pharmaceutical companies.

  5. Creating and Exploring Huge Parameter Spaces: Interactive Evolution as a Tool for Sound Generation

    DEFF Research Database (Denmark)

    Dahlstedt, Palle

    2001-01-01

    of huge synthesis parameter spaces, and presents a possibility for the sound artist to create new sound engines customized for this kind of creation and exploration – sound engines too complex to control in any other way. Different sound engines are presented, together with a discussion of compositional......In this paper, a program is presented that applies interactive evolution to sound generation, i.e., preferred individuals are repeatedly selected from a population of genetically bred sound objects, created with various synthesis and pattern generation algorithms. This simplifies aural exploration...

  6. Optimal Fungal Space Searching Algorithms.

    Science.gov (United States)

    Asenova, Elitsa; Lin, Hsin-Yu; Fu, Eileen; Nicolau, Dan V; Nicolau, Dan V

    2016-10-01

    Previous experiments have shown that fungi use an efficient natural algorithm for searching the space available for their growth in micro-confined networks, e.g., mazes. This natural "master" algorithm, which comprises two "slave" sub-algorithms, i.e., collision-induced branching and directional memory, has been shown to be more efficient than alternatives, with one, or the other, or both sub-algorithms turned off. In contrast, the present contribution compares the performance of the fungal natural algorithm against several standard artificial homologues. It was found that the space-searching fungal algorithm consistently outperforms uninformed algorithms, such as Depth-First-Search (DFS). Furthermore, while the natural algorithm is inferior to informed ones, such as A*, this under-performance does not importantly increase with the increase of the size of the maze. These findings suggest that a systematic effort of harvesting the natural space searching algorithms used by microorganisms is warranted and possibly overdue. These natural algorithms, if efficient, can be reverse-engineered for graph and tree search strategies.

  7. Pruning state spaces with extended beam search

    NARCIS (Netherlands)

    Dashti, M.T.; Wijs, A.J.

    2007-01-01

    This paper focuses on using beam search, a heuristic search algorithm, for pruning state spaces while generating. The original beam search is adapted to the state space generation setting and two new search variants are devised. The resulting framework encompasses some known algorithms, such as $A^*

  8. Search for Antimatter in Space

    CERN Multimedia

    2002-01-01

    PAMELA is a cosmic ray space experiment that will be installed on board of the Russian satellite Resurs-DK1 whose launch is scheduled at the end of 2002. The duration of the mission will be at least three years in a high latitude orbit at an altitude ranging between 350 and 600 Km. \\\\ The observational objectives of the PAMELA experiment are the measurement of the spectra of antiprotons, positrons, particles and nuclei in a wide range of energies, the search for antinuclei and the study of the cosmic ray fluxes during a portion of a solar cycle. The main scientific objectives can be schematically summarized as follows: \\\\ \\\\ a) measurement of the antiproton spectrum in the energy range 80 MeV-190 GeV;\\\\ b) measurement of the positron spectrum in the energy range 50 MeV-270 GeV;\\\\ c) search for antinuclei with a sensitivity of the order $10^{-8}$ in the $\\overline{He}/He$ ratio;\\\\ d) measurement of the nuclei spectra (from H to C) in the energy range 100 MeV/n - 200 GeV/n;\\\\ e) energy spectrum of the electroni...

  9. Space searches with a quantum robot

    Energy Technology Data Exchange (ETDEWEB)

    Benioff, P.

    2000-02-15

    Quantum robots are described as mobile quantum computers and ancillary systems that move in and interact with arbitrary environments. Their dynamics is given as tasks which consist of sequences of alternating computation and action phases. A task example is considered in which a quantum robot searches a space region to find the location of a system. The possibility that the search can be more efficient than a classical search is examined by considering use of Grover's Algorithm to process the search results. This is problematic for two reasons. One is the removal of entanglements generated by the (reversible) search process. The other is that (ignoring the entanglement problem), the search process in 2 dimensional space regions is no more efficient than a classical search. However quantum searches of higher dimensional space regions are more efficient than classical searches. Reasons why quantum robots are interesting independent of these results are briefly summarized.

  10. Space Searches with a Quantum Robot

    CERN Document Server

    Benioff, P

    2000-01-01

    Quantum robots are described as mobile quantum computers and ancillarysystems that move in and interact with arbitrary environments. Their dynamicsis given as tasks which consist of sequences of alternating computation andaction phases. A task example is considered in which a quantum robot searches aspace region to find the location of a system. The possibility that the searchcan be more efficient than a classical search is examined by considering use ofGrover's Algorithm to process the search results. For reversible searches thisis problematic for two reasons. One is the removal of entanglements generatedby the search process. The other is that even if the entanglement can beavoided, the search process in 2-D space regions is no more efficient than aclassical search. However, quantum searches of space regions with 3 or moredimensions are more efficient than classical searches. Reasons why quantumrobots are interesting independent of these results are briefly summarized.

  11. Search-Space Characterization for Real-time Heuristic Search

    OpenAIRE

    Huntley, Daniel; Bulitko, Vadim

    2013-01-01

    Recent real-time heuristic search algorithms have demonstrated outstanding performance in video-game pathfinding. However, their applications have been thus far limited to that domain. We proceed with the aim of facilitating wider applications of real-time search by fostering a greater understanding of the performance of recent algorithms. We first introduce eight algorithm-independent complexity measures for search spaces and correlate their values with algorithm performance. The complexity ...

  12. Space based microlensing planet searches

    Directory of Open Access Journals (Sweden)

    Tisserand Patrick

    2013-04-01

    Full Text Available The discovery of extra-solar planets is arguably the most exciting development in astrophysics during the past 15 years, rivalled only by the detection of dark energy. Two projects unite the communities of exoplanet scientists and cosmologists: the proposed ESA M class mission EUCLID and the large space mission WFIRST, top ranked by the Astronomy 2010 Decadal Survey report. The later states that: “Space-based microlensing is the optimal approach to providing a true statistical census of planetary systems in the Galaxy, over a range of likely semi-major axes”. They also add: “This census, combined with that made by the Kepler mission, will determine how common Earth-like planets are over a wide range of orbital parameters”. We will present a status report of the results obtained by microlensing on exoplanets and the new objectives of the next generation of ground based wide field imager networks. We will finally discuss the fantastic prospect offered by space based microlensing at the horizon 2020–2025.

  13. Combining search space partition and search Space partition and abstraction for LTL model checking

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The state space explosion problem is still the key obstacle for applying model checking to systems of industrial size.Abstraction-based methods have been particularly successful in this regard.This paper presents an approach based on refinement of search space partition and abstraction which combines these two techniques for reducing the complexity of model checking.The refinement depends on the representation of each portion of search space. Especially, search space can be refined stepwise to get a better reduction. As reported in the case study, the Integration of search space partition and abstraction improves the efficiencyof verification with respect to the requirement of memory and obtains significant advantage over the use of each of them in isolation.

  14. Similarity searching in large combinatorial chemistry spaces

    Science.gov (United States)

    Rarey, Matthias; Stahl, Martin

    2001-06-01

    We present a novel algorithm, called Ftrees-FS, for similarity searching in large chemistry spaces based on dynamic programming. Given a query compound, the algorithm generates sets of compounds from a given chemistry space that are similar to the query. The similarity search is based on the feature tree similarity measure representing molecules by tree structures. This descriptor allows handling combinatorial chemistry spaces as a whole instead of looking at subsets of enumerated compounds. Within few minutes of computing time, the algorithm is able to find the most similar compound in very large spaces as well as sets of compounds at an arbitrary similarity level. In addition, the diversity among the generated compounds can be controlled. A set of 17 000 fragments of known drugs, generated by the RECAP procedure from the World Drug Index, was used as the search chemistry space. These fragments can be combined to more than 1018 compounds of reasonable size. For validation, known antagonists/inhibitors of several targets including dopamine D4, histamine H1, and COX2 are used as queries. Comparison of the compounds created by Ftrees-FS to other known actives demonstrates the ability of the method to jump between structurally unrelated molecule classes.

  15. Colored Range Searching in Linear Space

    DEFF Research Database (Denmark)

    Grossi, Roberto; Vind, Søren Juhl

    2014-01-01

    In colored range searching, we are given a set of n colored points in d ≥ 2 dimensions to store, and want to support orthogonal range queries taking colors into account. In the colored range counting problem, a query must report the number of distinct colors found in the query range, while...... an answer to the colored range reporting problem must report the distinct colors in the query range. We give the first linear space data structure for both problems in two dimensions (d = 2) with o(n) worst case query time. We also give the first data structure obtaining almost-linear space usage and o...

  16. Spaced-based search coil magnetometers

    Science.gov (United States)

    Hospodarsky, George B.

    2016-12-01

    Search coil magnetometers are one of the primary tools used to study the magnetic component of low-frequency electromagnetic waves in space. Their relatively small size, mass, and power consumption, coupled with a good frequency range and sensitivity, make them ideal for spaceflight applications. The basic design of a search coil magnetometer consists of many thousands of turns of wire wound on a high permeability core. When a time-varying magnetic field passes through the coil, a time-varying voltage is induced due to Faraday's law of magnetic induction. The output of the coil is usually attached to a preamplifier, which amplifies the induced voltage and conditions the signal for transmission to the main electronics (usually a low-frequency radio receiver). Search coil magnetometers are usually used in conjunction with electric field antenna to measure electromagnetic plasma waves in the frequency range of a few hertz to a few tens of kilohertzs. Search coil magnetometers are used to determine the properties of waves, such as comparing the relative electric and magnetic field amplitudes of the waves, or to investigate wave propagation parameters, such as Poynting flux and wave normal vectors. On a spinning spacecraft, they are also sometimes used to determine the background magnetic field. This paper presents some of the basic design criteria of search coil magnetometers and discusses design characteristics of sensors flown on a number of spacecraft.

  17. Exoplanet Searches by Future Deep Space Missions

    Directory of Open Access Journals (Sweden)

    Maccone C.

    2011-02-01

    Full Text Available The search for exoplanets could benefit from gravitational lensing if we could get to 550 AU from the Sun and beyond. This is because the gravitational lens of the Sun would highly intensify there any weak electromagnetic wave reaching the solar system from distant planets in the Galaxy (see Maccone 2009. The gravitational lens of the Sun, however, has a drawback: the solar Corona. Electrons in the Corona make electromagnetic waves diverge and this pushes the focus out to distances higher than 550 AU. Jupiter is the second larger mass in the solar system after the Sun, but in this focal game not only the mass matters: rather, what really matters is the ratio between the radius of the body squared and the mass of the body. In this regard, Jupiter qualifies as the second best choice for a space mission, requiring the spacecraft to reach 6,077 AU. In this paper, we study the benefit of exoplanet searches by deep space missions.

  18. Exhaustive search system and method using space-filling curves

    Science.gov (United States)

    Spires, Shannon V.

    2003-10-21

    A search system and method for one agent or for multiple agents using a space-filling curve provides a way to control one or more agents to cover an area of any space of any dimensionality using an exhaustive search pattern. An example of the space-filling curve is a Hilbert curve. The search area can be a physical geography, a cyberspace search area, or an area searchable by computing resources. The search agent can be one or more physical agents, such as a robot, and can be software agents for searching cyberspace.

  19. Saccadic search performance: the effect of element spacing.

    Science.gov (United States)

    Vlaskamp, Björn N S; Over, Eelco A B; Hooge, Ignace Th C

    2005-11-01

    In a saccadic search task, we investigated whether spacing between elements affects search performance. Since it has been suggested in the literature that element spacing can affect the eye movement strategy in several ways, its effects on search time per element are hard to predict. In the first experiment, we varied the element spacing (3.4 degrees -7.1 degrees distance between elements) and target-distracter similarity. As expected, search time per element increased with target-distracter similarity. Decreasing element spacing decreased the search time per element. However, this effect was surprisingly small in comparison to the effect of varying target-distracter similarity. In a second experiment, we elaborated on this finding and decreased element spacing even further (between 0.8 degrees and 3.2 degrees). Here, we did not find an effect on search time per element for element spacings from 3.2 degrees to spacings as small as 1.5 degrees . It was only at distances smaller than 1.5 degrees that search time per element increased with decreasing element spacing. In order to explain the remarkable finding that search time per element was not affected for such a wide range of element spacings, we propose that irrespective of the spacing crowding kept the number of elements processed per fixation more or less constant.

  20. Search for complex organic molecules in space

    Science.gov (United States)

    Ohishi, Masatoshi

    2016-07-01

    It was 1969 when the first organic molecule in space, H2CO, was discovered. Since then many organic molecules were discovered by using the NRAO 11 m (upgraded later to 12 m), Nobeyama 45 m, IRAM 30 m, and other highly sensitive radio telescopes as a result of close collaboration between radio astronomers and microwave spectroscopists. It is noteworthy that many famous organic molecules such as CH3OH, C2H5OH, (CH3)2O and CH3NH2 were detected by 1975. Organic molecules were found in so-called hot cores where molecules were thought to form on cold dust surfaces and then to evaporate by the UV photons emitted from the central star. These days organic molecules are known to exist not only in hot cores but in hot corinos (a warm, compact molecular clump found in the inner envelope of a class 0 protostar) and even protoplanetary disks. As was described above, major organic molecules were known since 1970s. It was very natural that astronomers considered a relationship between organic molecules in space and the origin of life. Several astronomers challenged to detect glycine and other prebiotic molecules without success. ALMA is expected to detect such important materials to further consider the gexogenous deliveryh hypothesis. In this paper I summarize the history in searching for complex organic molecules together with difficulties in observing very weak signals from larger species. The awfully long list of references at the end of this article may be the most useful part for readers who want to feel the exciting discovery stories.

  1. Putting Continuous Metaheuristics to Work in Binary Search Spaces

    Directory of Open Access Journals (Sweden)

    Broderick Crawford

    2017-01-01

    Full Text Available In the real world, there are a number of optimization problems whose search space is restricted to take binary values; however, there are many continuous metaheuristics with good results in continuous search spaces. These algorithms must be adapted to solve binary problems. This paper surveys articles focused on the binarization of metaheuristics designed for continuous optimization.

  2. Minimizing the Integer Ambiguity Search Space for RTK

    Institute of Scientific and Technical Information of China (English)

    Yang Yun-chun; R. R. Hatch; R. T. Sharpe

    2003-01-01

    Differential GPS carrier phase measurements have much lower noise and multipath error than that of pseudorange measurements.The result is centimeter accuracy for Real-Time Kinematic (RTK).However, the measurement of the carrier phase has a constant unknown integer ambiguity. Several technical issues are related to solving the integer ambiguity correctly. They are: proper stochastic model, search space definition and initialization, search space reduction, state and standard deviation calculation, validation and rejection criteria for the unique and correct candidate. Search space reduction is critically important. It not only affects the ambiguity resolution speed, but also defines the ambiguity resolution success rate. The smaller the search space, the easier it is to find the unique and correct candidate set. The paper analyzes the integer ambiguity search space in its residual domain.The search space is minimized by: Analyzing the maximum independent integer ambiguity measurement set theoretically; Selecting the best initial measurement set that minimizes the search range of each satellite in the set and reduces the error effects from noise that may cause the wrong integer ambiguity solution for the remaining satellites not contained in the initial measurement set.Since the Residual Sensitive Matrix (S-Matrix) relates the integer ambiguity candidate set directly to post-fix residuals, it is not necessary to compute a fix for each candidate set thus making the integ erambiguity search process much more efficient. Also, minimizing the search space in the residual domain improves the search efficiency significantly and at the same time improves its reliability. Performance issues, such as recursive and weighted search techniques as well as methods for improving reliability, are also discussed in the article.

  3. Space-efficient parallel algorithms for combinatorial search problems

    DEFF Research Database (Denmark)

    Pietrcaprina, Andrea; Pucci, Geppino; Silvestri, Francesco;

    2015-01-01

    We present space-efficient parallel strategies for two fundamental combinatorial search problems, namely, backtrack search and branch-and-bound , both involving the visit of an n-node tree of height h under the assumption that a node can be accessed only through its father or its children. For both...... problems we propose efficient algorithms that run on a p-processor distributed-memory machine. For backtrack search, we give a deterministic algorithm running in O(n/p+hlogp) time, and a Las Vegas algorithm requiring optimal O(n/p+h) time, with high probability. Building on the backtrack search algorithm...

  4. Search for the Data of Space Debris Initial Distribution

    Science.gov (United States)

    Ping-Ping, Zhang; Bao-Jun, Pang

    Space debris environment model is one of the kernels of the research on space debris Space debris environment model is based on the data of space debris that is if we have the data of space debris orbit parameter we can determine the state of space debris distribution and then the spacecraft risk assessment can be executed Because numbers of small size space debris cannot be detected or observed we have not small size space debris data The short of small size space debris data leads to the engineering model inaccurate model needs to be updated while in the status of seriously short of data the model can not be updated in time In allusion to the problem of scarcity of data on the basis of modern computer arithmetic this paper is trying to search new data with old data and the results of the model is close to other engineering models Key words space debris data

  5. Novelty Search for Soft Robotic Space Exploration

    NARCIS (Netherlands)

    Methenitis, G.; Hennes, D.; Izzo, D.; Visser, A.

    2015-01-01

    The use of soft robots in future space exploration is still a far-fetched idea, but an attractive one. Soft robots are inherently compliant mechanisms that are well suited for locomotion on rough terrain as often faced in extra-planetary environments. Depending on the particular application and requ

  6. Novelty Search for Soft Robotic Space Exploration

    NARCIS (Netherlands)

    G. Methenitis (Georgios); D. Hennes; D. Izzo; A. Visser

    2015-01-01

    textabstractThe use of soft robots in future space exploration is still a far-fetched idea, but an attractive one. Soft robots are inherently compliant mechanisms that are well suited for locomotion on rough terrain as often faced in extra-planetary environments. Depending on the particular

  7. MANAGEMENT OF HUGE ENCEPHALOCELE

    Directory of Open Access Journals (Sweden)

    Rajeev

    2015-11-01

    Full Text Available Among all neural tube defects, encephalocele incidents are 1 in 5000 live births. (1 Newborn with encephalocele may be associated with other congenital malformations. Encephalocele patient’s management pose many challenge to neurosurgeon due to other associated anomalies that may present like ventriculocele, Dandy Walker and Arnold-Chiari malformation, and difficult positioning airway management to anaesthesiologist. We discuss a case of huge encephalocele and its management

  8. Exploration of Stellarator Configuration Space with Global Search Methods

    Energy Technology Data Exchange (ETDEWEB)

    H.E. Mynick; N. Pomphrey; S. Ethier

    2001-09-10

    An exploration of stellarator configuration space z for quasi-axisymmetric stellarator (QAS) designs is discussed, using methods which provide a more global view of that space. To this end, we have implemented a ''differential evolution'' (DE) search algorithm in an existing stellarator optimizer, which is much less prone to become trapped in local, suboptimal minima of the cost function chi than the local search methods used previously. This search algorithm is complemented by mapping studies of chi over z aimed at gaining insight into the results of the automated searches. We find that a wide range of the attractive QAS configurations previously found fall into a small number of classes, with each class corresponding to a basin of chi(z). We develop maps on which these earlier stellarators can be placed, the relations among them seen, and understanding gained into the physics differences between them. It is also found that, while still large, the region of z space containing practically realizable QAS configurations is much smaller than earlier supposed.

  9. Searching chemical space with the Bayesian Idea Generator.

    Science.gov (United States)

    van Hoorn, Willem P; Bell, Andrew S

    2009-10-01

    The Pfizer Global Virtual Library (PGVL) is defined as a set compounds that could be synthesized using validated protocols and monomers. However, it is too large (10(12) compounds) to search by brute-force methods for close analogues of a given input structure. In this paper the Bayesian Idea Generator is described which is based on a novel application of Bayesian statistics to narrow down the search space to a prioritized set of existing library arrays (the default is 16). For each of these libraries the 6 closest neighbors are retrieved from the existing compound file, resulting in a screenable hypothesis of 96 compounds. Using the Bayesian models for library space, the Pfizer file of singleton compounds has been mapped to library space and is optionally searched as well. The method is >99% accurate in retrieving known library provenance from an independent test set. The compounds retrieved strike a balance between similarity and diversity resulting in frequent scaffold hops. Four examples of how the Bayesian Idea Generator has been successfully used in drug discovery are provided. The methodology of the Bayesian Idea Generator can be used for any collection of compounds containing distinct clusters, and an example using compound vendor catalogues has been included.

  10. An ant colony algorithm on continuous searching space

    Science.gov (United States)

    Xie, Jing; Cai, Chao

    2015-12-01

    Ant colony algorithm is heuristic, bionic and parallel. Because of it is property of positive feedback, parallelism and simplicity to cooperate with other method, it is widely adopted in planning on discrete space. But it is still not good at planning on continuous space. After a basic introduction to the basic ant colony algorithm, we will propose an ant colony algorithm on continuous space. Our method makes use of the following three tricks. We search for the next nodes of the route according to fixed-step to guarantee the continuity of solution. When storing pheromone, it discretizes field of pheromone, clusters states and sums up the values of pheromone of these states. When updating pheromone, it makes good resolutions measured in relative score functions leave more pheromone, so that ant colony algorithm can find a sub-optimal solution in shorter time. The simulated experiment shows that our ant colony algorithm can find sub-optimal solution in relatively shorter time.

  11. Improved Maximum Entropy Method with an Extended Search Space

    CERN Document Server

    Rothkopf, Alexander

    2012-01-01

    We report on an improvement to the implementation of the Maximum Entropy Method (MEM). It amounts to departing from the search space obtained through a singular value decomposition (SVD) of the Kernel. Based on the shape of the SVD basis functions we argue that the MEM spectrum for given $N_\\tau$ data-points $D(\\tau)$ and prior information $m(\\omega)$ does not in general lie in this $N_\\tau$ dimensional singular subspace. Systematically extending the search basis will eventually recover the full search space and the correct extremum. We illustrate this idea through a mock data analysis inspired by actual lattice spectra, to show where our improvement becomes essential for the success of the MEM. To remedy the shortcomings of Bryan's SVD prescription we propose to use the real Fourier basis, which consists of trigonometric functions. Not only does our approach lead to more stable numerical behavior, as the SVD is not required for the determination of the basis functions, but also the resolution of the MEM beco...

  12. Subvoxel accurate graph search using non-Euclidean graph space.

    Directory of Open Access Journals (Sweden)

    Michael D Abràmoff

    Full Text Available Graph search is attractive for the quantitative analysis of volumetric medical images, and especially for layered tissues, because it allows globally optimal solutions in low-order polynomial time. However, because nodes of graphs typically encode evenly distributed voxels of the volume with arcs connecting orthogonally sampled voxels in Euclidean space, segmentation cannot achieve greater precision than a single unit, i.e. the distance between two adjoining nodes, and partial volume effects are ignored. We generalize the graph to non-Euclidean space by allowing non-equidistant spacing between nodes, so that subvoxel accurate segmentation is achievable. Because the number of nodes and edges in the graph remains the same, running time and memory use are similar, while all the advantages of graph search, including global optimality and computational efficiency, are retained. A deformation field calculated from the volume data adaptively changes regional node density so that node density varies with the inverse of the expected cost. We validated our approach using optical coherence tomography (OCT images of the retina and 3-D MR of the arterial wall, and achieved statistically significant increased accuracy. Our approach allows improved accuracy in volume data acquired with the same hardware, and also, preserved accuracy with lower resolution, more cost-effective, image acquisition equipment. The method is not limited to any specific imaging modality and readily extensible to higher dimensions.

  13. Fractional particle swarm optimization in multidimensional search space.

    Science.gov (United States)

    Kiranyaz, Serkan; Ince, Turker; Yildirim, Alper; Gabbouj, Moncef

    2010-04-01

    In this paper, we propose two novel techniques, which successfully address several major problems in the field of particle swarm optimization (PSO) and promise a significant breakthrough over complex multimodal optimization problems at high dimensions. The first one, which is the so-called multidimensional (MD) PSO, re-forms the native structure of swarm particles in such a way that they can make interdimensional passes with a dedicated dimensional PSO process. Therefore, in an MD search space, where the optimum dimension is unknown, swarm particles can seek both positional and dimensional optima. This eventually removes the necessity of setting a fixed dimension a priori, which is a common drawback for the family of swarm optimizers. Nevertheless, MD PSO is still susceptible to premature convergences due to lack of divergence. Among many PSO variants in the literature, none yields a robust solution, particularly over multimodal complex problems at high dimensions. To address this problem, we propose the fractional global best formation (FGBF) technique, which basically collects all the best dimensional components and fractionally creates an artificial global best (aGB) particle that has the potential to be a better "guide" than the PSO's native gbest particle. This way, the potential diversity that is present among the dimensions of swarm particles can be efficiently used within the aGB particle. We investigated both individual and mutual applications of the proposed techniques over the following two well-known domains: 1) nonlinear function minimization and 2) data clustering. An extensive set of experiments shows that in both application domains, MD PSO with FGBF exhibits an impressive speed gain and converges to the global optima at the true dimension regardless of the search space dimension, swarm size, and the complexity of the problem.

  14. Pylogeny: an open-source Python framework for phylogenetic tree reconstruction and search space heuristics

    OpenAIRE

    Alexander Safatli; Christian Blouin

    2015-01-01

    Summary. Pylogeny is a cross-platform library for the Python programming language that provides an object-oriented application programming interface for phylogenetic heuristic searches. Its primary function is to permit both heuristic search and analysis of the phylogenetic tree search space, as well as to enable the design of novel algorithms to search this space. To this end, the framework supports the structural manipulation of phylogenetic trees, in particular using rearrangement operator...

  15. Mutually beneficial relationship in optimization between search-space smoothing and stochastic search

    Science.gov (United States)

    Hasegawa, Manabu; Hiramatsu, Kotaro

    2013-10-01

    The effectiveness of the Metropolis algorithm (MA) (constant-temperature simulated annealing) in optimization by the method of search-space smoothing (SSS) (potential smoothing) is studied on two types of random traveling salesman problems. The optimization mechanism of this hybrid approach (MASSS) is investigated by analyzing the exploration dynamics observed in the rugged landscape of the cost function (energy surface). The results show that the MA can be successfully utilized as a local search algorithm in the SSS approach. It is also clarified that the optimization characteristics of these two constituent methods are improved in a mutually beneficial manner in the MASSS run. Specifically, the relaxation dynamics generated by employing the MA work effectively even in a smoothed landscape and more advantage is taken of the guiding function proposed in the idea of SSS; this mechanism operates in an adaptive manner in the de-smoothing process and therefore the MASSS method maintains its optimization function over a wider temperature range than the MA.

  16. Outdoor-indoor Space: Unified Modeling and Shortest Path Search

    DEFF Research Database (Denmark)

    Jensen, Søren Kejser; Nielsen, Jens Thomas Vejlby; Lu, Hua;

    2016-01-01

    Graph models are widely used for representing the topology of outdoor space (O-Space) and indoor space (I-Space). However, existing models neglect the intersection between O-Space and I-Space, only allowing for computations such as shortest path and nearest neighbor queries in either O-Space or I...

  17. Spacing affects some but not all visual searches: implications for theories of attention and crowding.

    Science.gov (United States)

    Reddy, Lavanya; VanRullen, Rufin

    2007-02-02

    We investigated the effect of varying interstimulus spacing on an upright among inverted face search and a red-green among green-red bisected disk search. Both tasks are classic examples of serial search; however, spacing affects them very differently: As spacing increased, face discrimination performance improved significantly, whereas performance on the bisected disks remained poor. (No effect of spacing was observed for either a red among green or an L among + search tasks, two classic examples of parallel search.) In a second experiment, we precued the target location so that attention was no longer a limiting factor: Both serial search tasks were now equally affected by spacing, a result we attribute to a more classical form of crowding. The observed spacing effect in visual search suggests that for certain tasks, serial search may result from local neuronal competition between target and distractors, soliciting attentional resources; in other cases, serial search must occur for another reason, for example, because an item-by-item, attention-mediated recognition must take place. We speculate that this distinction may be based on whether or not there exist neuronal populations tuned to the relevant target-distractor distinction, and we discuss the possible relations between this spacing effect in visual search and other forms of crowding.

  18. FAAST: Flow-space Assisted Alignment Search Tool

    Directory of Open Access Journals (Sweden)

    Persson Bengt

    2011-07-01

    Full Text Available Abstract Background High throughput pyrosequencing (454 sequencing is the major sequencing platform for producing long read high throughput data. While most other sequencing techniques produce reading errors mainly comparable with substitutions, pyrosequencing produce errors mainly comparable with gaps. These errors are less efficiently detected by most conventional alignment programs and may produce inaccurate alignments. Results We suggest a novel algorithm for calculating the optimal local alignment which utilises flowpeak information in order to improve alignment accuracy. Flowpeak information can be retained from a 454 sequencing run through interpretation of the binary SFF-file format. This novel algorithm has been implemented in a program named FAAST (Flow-space Assisted Alignment Search Tool. Conclusions We present and discuss the results of simulations that show that FAAST, through the use of the novel algorithm, can gain several percentage points of accuracy compared to Smith-Waterman-Gotoh alignments, depending on the 454 data quality. Furthermore, through an efficient multi-thread aware implementation, FAAST is able to perform these high quality alignments at high speed. The tool is available at http://www.ifm.liu.se/bioinfo/

  19. AN IMPROVED GENETIC ALGORITHM FOR SEARCHING OPTIMAL PARAMETERS IN n—DIMENSIONAL SPACE

    Institute of Scientific and Technical Information of China (English)

    TangBin; HuGuangrui

    2002-01-01

    An improved genetic algorithm for searching optimal parameters in n-dimensional space is presented,which encodes movement direction and distance and searches from coarse to precise.The algorithm can realize global optimization and improve the search efficiency,and can be applied effectively in industrial optimization ,data mining and pattern recognition.

  20. AN IMPROVED GENETIC ALGORITHM FOR SEARCHING OPTIMAL PARAMETERS IN n-DIMENSIONAL SPACE

    Institute of Scientific and Technical Information of China (English)

    Tang Bin; Hu Guangrui

    2002-01-01

    An improved genetic algorithm for searching optimal parameters in n-dimensional space is presented, which encodes movement direction and distance and searches from coarse to precise. The algorithm can realize global optimization and improve the search efficiency, and can be applied effectively in industrial optimization, data mining and pattern recognition.

  1. Huge music archives on mobile devices

    DEFF Research Database (Denmark)

    Blume, H.; Bischl, B.; Botteck, M.

    2011-01-01

    The availability of huge nonvolatile storage capacities such as flash memory allows large music archives to be maintained even in mobile devices. With the increase in size, manual organization of these archives and manual search for specific music becomes very inconvenient. Automated dynamic...... and difficult to tackle on mobile platforms. Against this background, we provided an overview of algorithms for music classification as well as their computation times and other hardware-related aspects, such as power consumption on various hardware architectures. For mobile platforms such as smartphones...

  2. Linking Search Space Structure, Run-Time Dynamics, and Problem Difficulty: A Step Toward Demystifying Tabu Search

    CERN Document Server

    Howe, A E; Whitley, L D; 10.1613/jair.1576

    2011-01-01

    Tabu search is one of the most effective heuristics for locating high-quality solutions to a diverse array of NP-hard combinatorial optimization problems. Despite the widespread success of tabu search, researchers have a poor understanding of many key theoretical aspects of this algorithm, including models of the high-level run-time dynamics and identification of those search space features that influence problem difficulty. We consider these questions in the context of the job-shop scheduling problem (JSP), a domain where tabu search algorithms have been shown to be remarkably effective. Previously, we demonstrated that the mean distance between random local optima and the nearest optimal solution is highly correlated with problem difficulty for a well-known tabu search algorithm for the JSP introduced by Taillard. In this paper, we discuss various shortcomings of this measure and develop a new model of problem difficulty that corrects these deficiencies. We show that Taillards algorithm can be modeled with ...

  3. Attention searches nonuniformly in space and in time

    OpenAIRE

    Dugué, Laura; Mclelland, Douglas; Lajous, Mathilde; Vanrullen, Rufin

    2015-01-01

    Visual search is one of the primary tools to study attention in experimental psychology, yet the spatiotemporal behavior of attention during search remains controversial: Does attention focus on one item at a time or several, or even all, items? We used an innovative methodology that relies on simple yet elegant mathematical reasoning and only assumes (like most other attentional studies) that attentional strength is reflected in behavioral performance. We provide evidence against a strict pa...

  4. Search Space Calculation to Improve Parameter Estimation of Excitation Control Systems

    Directory of Open Access Journals (Sweden)

    Andrés J. Saavedra-Montes

    2013-11-01

    Full Text Available A method to calculate the search space for each parameter in an excitation control system is presented in this paper. The calculated search space is intended to reduce the number of parameter solution sets that can be found by an estimation algorithm, reducing its processing time. The method considers a synchronous generator time constant range between 4s and 10s, an excitation control system performance index, a controller design technique, and the excitation control system model structure. When the obtained search space is used to estimate the parameters, less processing time is used by the algorithm. Also the estimated parameters are closer to the reference ones.

  5. An extended dual search space model of scientific discovery learning

    NARCIS (Netherlands)

    Joolingen, van Wouter R.; Jong, de Ton

    1997-01-01

    This article describes a theory of scientific discovery learning which is an extension of Klahr and Dunbar''s model of Scientific Discovery as Dual Search (SDDS) model. We present a model capable of describing and understanding scientific discovery learning in complex domains in terms of the SDDS fr

  6. Search Space Calculation to Improve Parameter Estimation of Excitation Control Systems

    OpenAIRE

    2013-01-01

    A method to calculate the search space for each parameter in an excitation control system is presented in this paper. The calculated search space is intended to reduce the number of parameter solution sets that can be found by an estimation algorithm, reducing its processing time. The method considers a synchronous generator time constant range between 4s and 10s, an excitation control system performance index, a controller design technique, and the excitation control system model structure. ...

  7. "Space of physics journals": in search of journals of quality

    CERN Document Server

    Katchanov, Yurij L

    2016-01-01

    This paper analyses the problem of scientific quality of physics journals. The main assumption is that the quality of a physics journal exists only in reference to other journals. Instead of constructing new indicators of scientific quality, we identify a physical journal with corresponding empirical distribution function of citations. From our relational point of view, the space of physics journals is only a system of differences between empirical distribution functions of citations. Using data from Web of Science Core Collection we consider the space of physics journals and the space of scientific publishers. The first provides an objective basis for the grouping of physics journals on the basis of a whole range of indicators (citation statistics, country, publisher, etc.). The second reveals the "competitors' triangle" of regional publishers, transnational publishers and professional physical societies. These findings have prompted us to advance the hypothesis that the structure of the space of physics jou...

  8. Optimization of a genetic algorithm for searching molecular conformer space

    Science.gov (United States)

    Brain, Zoe E.; Addicoat, Matthew A.

    2011-11-01

    We present two sets of tunings that are broadly applicable to conformer searches of isolated molecules using a genetic algorithm (GA). In order to find the most efficient tunings for the GA, a second GA - a meta-genetic algorithm - was used to tune the first genetic algorithm to reliably find the already known a priori correct answer with minimum computational resources. It is shown that these tunings are appropriate for a variety of molecules with different characteristics, and most importantly that the tunings are independent of the underlying model chemistry but that the tunings for rigid and relaxed surfaces differ slightly. It is shown that for the problem of molecular conformational search, the most efficient GA actually reduces to an evolutionary algorithm.

  9. Galaxies Collide to Create Hot, Huge Galaxy

    Science.gov (United States)

    2009-01-01

    This image of a pair of colliding galaxies called NGC 6240 shows them in a rare, short-lived phase of their evolution just before they merge into a single, larger galaxy. The prolonged, violent collision has drastically altered the appearance of both galaxies and created huge amounts of heat turning NGC 6240 into an 'infrared luminous' active galaxy. A rich variety of active galaxies, with different shapes, luminosities and radiation profiles exist. These galaxies may be related astronomers have suspected that they may represent an evolutionary sequence. By catching different galaxies in different stages of merging, a story emerges as one type of active galaxy changes into another. NGC 6240 provides an important 'missing link' in this process. This image was created from combined data from the infrared array camera of NASA's Spitzer Space Telescope at 3.6 and 8.0 microns (red) and visible light from NASA's Hubble Space Telescope (green and blue).

  10. Determining Frequentist Confidence Limits Using a Directed Parameter Space Search

    Science.gov (United States)

    Daniel, Scott F.; Connolly, Andrew J.; Schneider, Jeff

    2014-10-01

    We consider the problem of inferring constraints on a high-dimensional parameter space with a computationally expensive likelihood function. We propose a machine learning algorithm that maps out the Frequentist confidence limit on parameter space by intelligently targeting likelihood evaluations so as to quickly and accurately characterize the likelihood surface in both low- and high-likelihood regions. We compare our algorithm to Bayesian credible limits derived by the well-tested Markov Chain Monte Carlo (MCMC) algorithm using both multi-modal toy likelihood functions and the seven yr Wilkinson Microwave Anisotropy Probe cosmic microwave background likelihood function. We find that our algorithm correctly identifies the location, general size, and general shape of high-likelihood regions in parameter space while being more robust against multi-modality than MCMC.

  11. Down the Rabbit Hole: Robust Proximity Search in Sublinear Space

    CERN Document Server

    Har-Peled, Sariel

    2011-01-01

    For a set of n points in $\\Re^d$, and parameters k and {\\epsilon}, we present a data structure that answers (1 + {\\epsilon})-approximate k nearest neighbor queries in logarithmic time. Surprisingly, the space used by the data-structure is O(n/k), that is, the space used is sublinear in the input size if k is sufficiently large. Our approach provides a novel way to summarize geometric data, such that meaningful proximity queries on the data can be carried out using this sketch.

  12. Deep Space Detectives: Searching for Planets Suitable for Life

    Science.gov (United States)

    Pallant, Amy; Damelin, Daniel; Pryputniewicz, Sarah

    2013-01-01

    This article describes the High-Adventure Science curriculum unit "Is There Life in Space?" This free online investigation, developed by The Concord Consortium, helps students see how scientists use modern tools to locate planets around distant stars and explore the probability of finding extraterrestrial life. This innovative curriculum…

  13. Deep Space Detectives: Searching for Planets Suitable for Life

    Science.gov (United States)

    Pallant, Amy; Damelin, Daniel; Pryputniewicz, Sarah

    2013-01-01

    This article describes the High-Adventure Science curriculum unit "Is There Life in Space?" This free online investigation, developed by The Concord Consortium, helps students see how scientists use modern tools to locate planets around distant stars and explore the probability of finding extraterrestrial life. This innovative curriculum…

  14. Finite Line-transitive Linear Spaces: Theory and Search Strategies

    Institute of Scientific and Technical Information of China (English)

    Anton BETTEN; Anne DELANDTSHEER; Maska LAW; Alice C. NIEMEYER; Cheryl E. PRAEGER; Shenglin ZHOU

    2009-01-01

    The paper summarises existing theory and classifications for finite line-transitive linear spaces, develops the theory further, and organises it in a way that enables its effective application. The starting point is a theorem of Camina and the fifth author that identifies three kinds of line-transitive automorphism groups of linear spaces. In two of these cases the group may be imprimitive on points, that is, the group leaves invariant a nontrivial partition of the point set. In the first of these cases the group is almost simple with point-transitive simple socle, and may or may not be point-primitive, while in the second case the group has a non-trivial point-intransitive normal subgroup and hence is definitely point-imprimitive. The theory presented here focuses on point-imprimitive groups. As a non-trivial application a classification is given of the point-imprimitive, line-transitive groups, and the corresponding linear spaces, for which the greatest common divisor gcd(k, v - 1) ≤ 8, where v is the number of points, and k is the line size. Motivation for this classification comes from a result of Weidong Fang and Huiling Li in 1993, that there are only finitely many non-trivial point-imprimitive, line-transitive linear spaces for a given value of gcd(k, v- 1). The classification strengthens the classification by Camina and Mischke under the much stronger restriction k ≤ 8: no additional examples arise. The paper provides the backbone for future computer-based classifications of point-imprimitive, line-transitive linear spaces with small parameters. Several suggestions for further investigations are made.

  15. Parameter-space metric of semicoherent searches for continuous gravitational waves

    CERN Document Server

    Pletsch, Holger J

    2010-01-01

    Continuous gravitational-wave (CW) signals such as emitted by spinning neutron stars are an important target class for current detectors. However, the enormous computational demand prohibits fully-coherent broadband all-sky searches for prior unknown CW sources over wide ranges of parameter space and for year-long observation times. More efficient hierarchical "semicoherent" search strategies divide the data into segments much shorter than one year, which are analyzed coherently; then detection statistics from different segments are combined incoherently. To optimally perform the incoherent combination, understanding of the underlying parameter-space structure is requisite. This problem is addressed here by using new coordinates on the parameter space, which yield the first analytical parameter-space metric for the incoherent combination step. This semicoherent metric applies to broadband all-sky surveys (also embedding directed searches at fixed sky position) for isolated CW sources. Furthermore, the additio...

  16. Searching for recursively defined generic chemical patterns in nonenumerated fragment spaces.

    Science.gov (United States)

    Ehrlich, Hans-Christian; Henzler, Angela M; Rarey, Matthias

    2013-07-22

    Retrieving molecules with specific structural features is a fundamental requirement of today's molecular database technologies. Estimates claim the chemical space relevant for drug discovery to be around 10⁶⁰ molecules. This figure is many orders of magnitude larger than the amount of molecules conventional databases retain today and will store in the future. An elegant description of such a large chemical space is provided by the concept of fragment spaces. A fragment space comprises fragments that are molecules with open valences and describes rules how to connect these fragments to products. Due to the combinatorial nature of fragment spaces, a complete enumeration of its products is intractable. We present an algorithm to search fragment spaces for generic chemical patterns as present in the SMARTS chemical pattern language. Our method allows specification of the chemical surrounding of an atom in a query and, therefore, enables a chemically intuitive search. During the search, the costly enumeration of products is avoided. The result is a fragment space that exactly describes all possible molecules that contain the user-defined pattern. We evaluated the algorithm in three different drug development use-cases and performed a large scale statistical analysis with 738 SMARTS patterns on three public available fragment spaces. Our results show the ability of the algorithm to explore the chemical space around known active molecules, to analyze fragment spaces for the presence of likely toxic molecules, and to identify complex macromolecular structures under additional structural constraints. By searching the fragment space in its nonenumerated form, spaces covering up to 10¹⁹ molecules can be examined in times ranging between 47 s and 19 min depending on the complexity of the query pattern.

  17. On High Dimensional Searching Spaces and Learning Methods

    DEFF Research Database (Denmark)

    Yazdani, Hossein; Ortiz-Arroyo, Daniel; Choros, Kazimierz

    2017-01-01

    In data science, there are important parameters that affect the accuracy of the algorithms used. Some of these parameters are: the type of data objects, the membership assignments, and distance or similarity functions. In this chapter we describe different data types , membership functions...... , and similarity functions and discuss the pros and cons of using each of them. Conventional similarity functions evaluate objects in the vector space. Contrarily, Weighted Feature Distance (WFD) functions compare data objects in both feature and vector spaces, preventing the system from being affected by some...... dominant features. Traditional membership functions assign membership values to data objects but impose some restrictions. Bounded Fuzzy Possibilistic Method (BFPM) makes possible for data objects to participate fully or partially in several clusters or even in all clusters. BFPM introduces intervals...

  18. Federated Space-Time Query for Earth Science Data Using OpenSearch Conventions

    Science.gov (United States)

    Lynnes, C.; Beaumont, B.; Duerr, R. E.; Hua, H.

    2009-12-01

    The past decade has seen a burgeoning of remote sensing and Earth science data providers, as evidenced in the growth of the Earth Science Information Partner (ESIP) federation. At the same time, the need to combine diverse data sets to enable understanding of the Earth as a system has also grown. While the expansion of data providers is in general a boon to such studies, the diversity presents a challenge to finding useful data for a given study. Locating all the data files with aerosol information for a particular volcanic eruption, for example, may involve learning and using several different search tools to execute the requisite space-time queries. To address this issue, the ESIP federation is developing a federated space-time query framework, based on the OpenSearch convention (www.opensearch.org), with Geo and Time extensions. In this framework, data providers publish OpenSearch Description Documents that describe in a machine-readable form how to execute queries against the provider. The novelty of OpenSearch is that the space-time query interface becomes both machine callable and easy enough to integrate into the web browser's search box. This flexibility, together with a simple REST (HTTP-get) interface, should allow a variety of data providers to participate in the federated search framework, from large institutional data centers to individual scientists. The simple interface enables trivial querying of multiple data sources and participation in recursive-like federated searches--all using the same common OpenSearch interface. This simplicity also makes the construction of clients easy, as does existing OpenSearch client libraries in a variety of languages. Moreover, a number of clients and aggregation services already exist and OpenSearch is already supported by a number of web browsers such as Firefox and Internet Explorer.

  19. Teacher education physical education: In search of a hybrid space

    Directory of Open Access Journals (Sweden)

    Timothy Lynch

    2015-12-01

    Full Text Available It is argued that a learning environment underpinned by a strengths-based collaborative approach between universities and schools offers extended pre-service teacher learning opportunities and subsequently enhanced preparation. The term “hybrid space” describes the ideal environment of shared partnership where knowledge is jointly created, and consequently, as too is collaborative egalitarianism between stakeholders. This study investigates a possible “hybrid space” course within Physical Education Teacher Education (PETE in the UK. While much literature discusses the advantages of the “hybrid space” ideal across education disciplines, high-quality research into PETE hybrid spaces is limited, if not non-existent. Hence, the particular course was chosen for data collection as it advocates intricate connections with schools in the local community. Furthermore, the course was awarded “Outstanding” by the national regulatory authority, England and Wales Office for Standards in Education (Ofsted, one of the major reasons explicitly stated was for its community connections. A qualitative, interpretive study using a case study methodology was adopted to examine the successful primary PETE course. The findings offer insights into the ideal of hybrid spaces in PETE, which appear to benefit various stakeholders within communities. The study is significant as it assists teacher educators from around the world, challenged to rethink their connections between university courses and school field experiences through illustrating a highly successful example.

  20. Searching for fractal phenomena in multidimensional phase-spaces

    Science.gov (United States)

    Blažek, Mikuláš

    2000-07-01

    A unified point of view on the fractal analysis in d-dimensional phase-spaces is presented. It is applicable to the data coming from the counting experiments. Explicit expressions are formulated for the fundamental types of factorial moments characterizing the presence of the fractal phenomena, their number being given by (2 d+1 - 1), as well as for a variety of associated statistical moments; special attention is paid to two and three dimensions. In particular, it is found that scaling properties of the modified dispersion moments are directly related with the presence of empty bins in the corresponding distributions. As to the high-energy experiments, those expressions can be applied to the data presently available, e.g. from LEP, as well as to the data arising in the near future from heavy-ion collisions performed at the CERN collider and from the pp collisions observed at the Tevatron, Fermilab.

  1. Multi-robot searching with sparse binary cues and limited space perception

    Directory of Open Access Journals (Sweden)

    Siqi eZhang

    2015-05-01

    Full Text Available In this paper, we consider the problem of searching for a source that releases particles in a turbulent medium with searchers having binary sensors and limited space perception.To this aim, we extend an information-theoric strategy to multiple searchers and demonstrate its efficiency both in simulation and robotic experiments. The search time is found to decay as $1/n$ for $n$ cooperative robots as compared to $1/sqrt{n}$ for independent robots so that significant gains in the search time are obtained with a small number of robots, {it e.g.} $n=3$. Search efficiency results from pooling sensory information between robots to improve individual decision-making (three detections on average per searcher were sufficient to reach the source. The methods is robust to odometry errors and is thus relevant to robots searching in low visibility conditions, {it e.g.} firefighter robots exploring smoky environments.

  2. Formulation space search approach for the teacher/class timetabling problem

    Directory of Open Access Journals (Sweden)

    Kochetov Yuri

    2008-01-01

    Full Text Available We consider the well known NP-hard teacher/class timetabling problem. Variable neighborhood search and tabu search heuristics are developed based on idea of the Formulation Space Search approach. Two types of solution representation are used in the heuristics. For each representation we consider two families of neighborhoods. The first family uses swapping of time periods for teacher (class timetable. The second family bases on the idea of large Kernighan-Lin neighborhoods. Computation results for difficult random test instances show high efficiency of the proposed approach. .

  3. Composite Distance Transformation for Indexing and k-Nearest-Neighbor Searching in High-Dimensional Spaces

    Institute of Scientific and Technical Information of China (English)

    Yi Zhuang; Yue-Ting Zhuang; Fei Wu

    2007-01-01

    Due to the famous dimensionality curse problem, search in a high-dimensional space is considered as a "hard" problem. In this paper, a novel composite distance transformation method, which is called CDT, is proposed to support a fast k-nearest-neighbor (k-NN) search in high-dimensional spaces. In CDT, all (n) data points are first grouped into some clusters by a k-Means clustering algorithm. Then a composite distance key of each data point is computed. Finally, these index keys of such n data points are inserted by a partition-based B+-tree. Thus, given a query point, its k-NN search in high-dimensional spaces is transformed into the search in the single dimensional space with the aid of CDT index. Extensive performance studies are conducted to evaluate the effectiveness and efficiency of the proposed scheme. Our results showthat this method outperforms the state-of-the-art high-dimensional search techniques, such as the X-Tree, VA-file, iDistance and NB-Tree.

  4. Identification of Fuzzy Inference Systems by Means of a Multiobjective Opposition-Based Space Search Algorithm

    Directory of Open Access Journals (Sweden)

    Wei Huang

    2013-01-01

    Full Text Available We introduce a new category of fuzzy inference systems with the aid of a multiobjective opposition-based space search algorithm (MOSSA. The proposed MOSSA is essentially a multiobjective space search algorithm improved by using an opposition-based learning that employs a so-called opposite numbers mechanism to speed up the convergence of the optimization algorithm. In the identification of fuzzy inference system, the MOSSA is exploited to carry out the parametric identification of the fuzzy model as well as to realize its structural identification. Experimental results demonstrate the effectiveness of the proposed fuzzy models.

  5. Federated Space-Time Query for Earth Science Data Using OpenSearch Conventions

    Science.gov (United States)

    Lynnes, Chris; Beaumont, Bruce; Duerr, Ruth; Hua, Hook

    2009-01-01

    This slide presentation reviews a Space-time query system that has been developed to assist the user in finding Earth science data that fulfills the researchers needs. It reviews the reasons why finding Earth science data can be so difficult, and explains the workings of the Space-Time Query with OpenSearch and how this system can assist researchers in finding the required data, It also reviews the developments with client server systems.

  6. Pylogeny: an open-source Python framework for phylogenetic tree reconstruction and search space heuristics

    Directory of Open Access Journals (Sweden)

    Alexander Safatli

    2015-06-01

    Full Text Available Summary. Pylogeny is a cross-platform library for the Python programming language that provides an object-oriented application programming interface for phylogenetic heuristic searches. Its primary function is to permit both heuristic search and analysis of the phylogenetic tree search space, as well as to enable the design of novel algorithms to search this space. To this end, the framework supports the structural manipulation of phylogenetic trees, in particular using rearrangement operators such as NNI, SPR, and TBR, the scoring of trees using parsimony and likelihood methods, the construction of a tree search space graph, and the programmatic execution of a few existing heuristic programs. The library supports a range of common phylogenetic file formats and can be used for both nucleotide and protein data. Furthermore, it is also capable of supporting GPU likelihood calculation on nucleotide character data through the BEAGLE library.Availability. Existing development and source code is available for contribution and for download by the public from GitHub (http://github.com/AlexSafatli/Pylogeny. A stable release of this framework is available for download through PyPi (Python Package Index at http://pypi.python.org/pypi/pylogeny.

  7. Optimal Scheme for Search State Space and Scheduling on Multiprocessor Systems

    Science.gov (United States)

    Youness, Hassan A.; Sakanushi, Keishi; Takeuchi, Yoshinori; Salem, Ashraf; Wahdan, Abdel-Moneim; Imai, Masaharu

    A scheduling algorithm aims to minimize the overall execution time of the program by properly allocating and arranging the execution order of the tasks on the core processors such that the precedence constraints among the tasks are preserved. In this paper, we present a new scheduling algorithm by using geometry analysis of the Task Precedence Graph (TPG) based on A* search technique and uses a computationally efficient cost function for guiding the search with reduced complexity and pruning techniques to produce an optimal solution for the allocation/scheduling problem of a parallel application to parallel and multiprocessor architecture. The main goal of this work is to significantly reduce the search space and achieve the optimality or near optimal solution. We implemented the algorithm on general task graph problems that are processed on most of related search work and obtain the optimal scheduling with a small number of states. The proposed algorithm reduced the exhaustive search by at least 50% of search space. The viability and potential of the proposed algorithm is demonstrated by an illustrative example.

  8. Evolved finite state controller for hybrid system in reduced search space

    DEFF Research Database (Denmark)

    Dupuis, Jean-Francois; Fan, Zhun

    2009-01-01

    This paper presents an evolutionary methodology to automatically generate finite state automata (FSA) controllers to control hybrid systems. The proposed approach reduces the search space using an invariant analysis of the system. FSA controllers for a case study of two-tank system have been...

  9. Parameter-space metric of semicoherent searches for continuous gravitational waves

    Science.gov (United States)

    Pletsch, Holger J.

    2010-08-01

    Continuous gravitational-wave (CW) signals such as emitted by spinning neutron stars are an important target class for current detectors. However, the enormous computational demand prohibits fully coherent broadband all-sky searches for prior unknown CW sources over wide ranges of parameter space and for yearlong observation times. More efficient hierarchical “semicoherent” search strategies divide the data into segments much shorter than one year, which are analyzed coherently; then detection statistics from different segments are combined incoherently. To optimally perform the incoherent combination, understanding of the underlying parameter-space structure is requisite. This problem is addressed here by using new coordinates on the parameter space, which yield the first analytical parameter-space metric for the incoherent combination step. This semicoherent metric applies to broadband all-sky surveys (also embedding directed searches at fixed sky position) for isolated CW sources. Furthermore, the additional metric resolution attained through the combination of segments is studied. From the search parameters (sky position, frequency, and frequency derivatives), solely the metric resolution in the frequency derivatives is found to significantly increase with the number of segments.

  10. Intelligent Classification in Huge Heterogeneous Data Sets

    Science.gov (United States)

    2015-06-01

    INTELLIGENT CLASSIFICATION IN HUGE HETEROGENEOUS DATA SETS JUNE 2015 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED...To) JUL 2013 – APR 2015 4. TITLE AND SUBTITLE INTELLIGENT CLASSIFICATION IN HUGE HETEROGENEOUS DATA SETS 5a. CONTRACT NUMBER IN-HOUSE 5b. GRANT...signals and through data dimension reduction, and to develop and tailor algorithms for the extraction of intelligence from several huge heterogeneous

  11. Reduced Search Space Algorithm for Simultaneous Localization and Mapping in Mobile Robots

    Directory of Open Access Journals (Sweden)

    Hesam Omranpour

    2012-03-01

    Full Text Available In this paper, we propose a new algorithm for simultaneous localization and mapping in mobile robots which uses evolutionary algorithm and particle swarm optimization. The proposed method is based on both local and global heuristic search methods. In each step of robot movements, the local search is applied in the small search space of odometry errors to improve the map accuracy. A global search method is applied for loop closing. The proposed algorithm detects loops and closes them, detects and solves correspondence and avoids local extremums. With a proper representation of problem parameters in chromosome, the dimensionality of search space is reduced. The proposed algorithm utilizes occupancy grid and does not require land marks which are not available in most natural environments. A new fitness function is proposed that is computationally efficient and eliminates the need for complex statistical calculations as used in current approaches. Results of experiments on real datasets exhibit the superior performance of the proposed method compared to the current methods.

  12. Exhaustive geographic search with mobile robots along space-filling curves

    Energy Technology Data Exchange (ETDEWEB)

    Spires, S.V.; Goldsmith, S.Y.

    1998-03-01

    Swarms of mobile robots can be tasked with searching a geographic region for targets of interest, such as buried land mines. The authors assume that the individual robots are equipped with sensors tuned to the targets of interest, that these sensors have limited range, and that the robots can communicate with one another to enable cooperation. How can a swarm of cooperating sensate robots efficiently search a given geographic region for targets in the absence of a priori information about the target`s locations? Many of the obvious approaches are inefficient or lack robustness. One efficient approach is to have the robots traverse a space-filling curve. For many geographic search applications, this method is energy-frugal, highly robust, and provides guaranteed coverage in a finite time that decreases as the reciprocal of the number of robots sharing the search task. Furthermore, it minimizes the amount of robot-to-robot communication needed for the robots to organize their movements. This report presents some preliminary results from applying the Hilbert space-filling curve to geographic search by mobile robots.

  13. Results of a Hubble Space Telescope Search for Natural Satellites of Dwarf Planet 1 Ceres

    Science.gov (United States)

    DeMario, Benjamin; Schmidt, Britney E.; Mutchler, Maximilian J.; Li, Jian-Yang; McFadden, Lucy Ann; McLean, Brian; Russell, Christopher T.

    2016-10-01

    In order to prepare for the arrival of the Dawn spacecraft at Ceres, a search for satellites was undertaken by the Hubble Space Telescope (HST) to enhance the mission science return and to ensure spacecraft safety. Previous satellite searches from ground-based telescopes have detected no satellites within Ceres' Hill sphere down to a size of 3 km (Gehrels et al. 1987) and early HST investigations searched to a limit of 1-2 km (Bieryla et al. 2011). The Wide Field Camera 3 (WFC3) on board the HST was used to image Ceres between 14 April - 28 April 2014. These images cover approximately the inner third of Ceres' Hill sphere, where the Hill sphere is the region surrounding Ceres where stable satellite orbits are possible. We performed a deep search for possible companions orbiting Ceres. No natural companions were located down to a diameter of 48 meters, over most of the Hill sphere to a distance of 205,000 km (434 Ceres radii) from the surface of Ceres. It was impossible to search all the way to the surface of Ceres because of scattered light, but at a distance of 2865 km (five Ceres radii), the search limit was determined to be 925 meters. The absence of a satellite around Ceres could, in the future, support more refined theories about satellite formation or capture mechanisms in the solar system.

  14. ChemDB update--full-text search and virtual chemical space.

    Science.gov (United States)

    Chen, Jonathan H; Linstead, Erik; Swamidass, S Joshua; Wang, Dennis; Baldi, Pierre

    2007-09-01

    ChemDB is a chemical database containing nearly 5M commercially available small molecules, important for use as synthetic building blocks, probes in systems biology and as leads for the discovery of drugs and other useful compounds. The data is publicly available over the web for download and for targeted searches using a variety of powerful methods. The chemical data includes predicted or experimentally determined physicochemical properties, such as 3D structure, melting temperature and solubility. Recent developments include optimization of chemical structure (and substructure) retrieval algorithms, enabling full database searches in less than a second. A text-based search engine allows efficient searching of compounds based on over 65M annotations from over 150 vendors. When searching for chemicals by name, fuzzy text matching capabilities yield productive results even when the correct spelling of a chemical name is unknown, taking advantage of both systematic and common names. Finally, built in reaction models enable searches through virtual chemical space, consisting of hypothetical products readily synthesizable from the building blocks in ChemDB. ChemDB and Supplementary Materials are available at http://cdb.ics.uci.edu. Supplementary data are available at Bioinformatics online.

  15. The Surface Extraction from TIN based Search-space Minimization (SETSM) algorithm

    Science.gov (United States)

    Noh, Myoung-Jong; Howat, Ian M.

    2017-07-01

    Digital Elevation Models (DEMs) provide critical information for a wide range of scientific, navigational and engineering activities. Submeter resolution, stereoscopic satellite imagery with high geometric and radiometric quality, and wide spatial coverage are becoming increasingly accessible for generating stereo-photogrammetric DEMs. However, low contrast and repeatedly-textured surfaces, such as snow and glacial ice at high latitudes, and mountainous terrains challenge existing stereo-photogrammetric DEM generation techniques, particularly without a-priori information such as existing seed DEMs or the manual setting of terrain-specific parameters. To utilize these data for fully-automatic DEM extraction at a large scale, we developed the Surface Extraction from TIN-based Search-space Minimization (SETSM) algorithm. SETSM is fully automatic (i.e. no search parameter settings are needed) and uses only the sensor model Rational Polynomial Coefficients (RPCs). SETSM adopts a hierarchical, combined image- and object-space matching strategy utilizing weighted normalized cross-correlation with both original distorted and geometrically corrected images for overcoming ambiguities caused by foreshortening and occlusions. In addition, SETSM optimally minimizes search-spaces to extract optimal matches over problematic terrains by iteratively updating object surfaces within a Triangulated Irregular Network, and utilizes a geometric-constrained blunder and outlier detection in object space. We prove the ability of SETSM to mitigate typical stereo-photogrammetric matching problems over a range of challenging terrains. SETSM is the primary DEM generation software for the US National Science Foundation's ArcticDEM project.

  16. Bayesian Variable Selection via Particle Stochastic Search.

    Science.gov (United States)

    Shi, Minghui; Dunson, David B

    2011-02-01

    We focus on Bayesian variable selection in regression models. One challenge is to search the huge model space adequately, while identifying high posterior probability regions. In the past decades, the main focus has been on the use of Markov chain Monte Carlo (MCMC) algorithms for these purposes. In this article, we propose a new computational approach based on sequential Monte Carlo (SMC), which we refer to as particle stochastic search (PSS). We illustrate PSS through applications to linear regression and probit models.

  17. Implementation of Liouville space search algorithm on strongly dipolar coupled nuclear spins

    CERN Document Server

    Gopinath, T

    2009-01-01

    Liouville space search algorithm [Bruschweiler, Phys. Rev. Lett. {\\bf 85}, 4815(2000).] utilizes mixed initial states of the ensemble, and has been successfully implemented earlier in weakly coupled spins, in which a spin can be identified as a qubit. It has recently been demonstrated that n-strongly coupled spins can be collectively treated as an n-qubit system. Application of algorithms in such systems, requires new approaches using transition selective pulses rather than qubit selective pulses. This work develops a modified version of Liouville space search algorithm, which is applicable for strongly as well as weakly coupled spins. All the steps of the algorithm, can be implemented by using transition selective pulses. Experimental implementation is carried out on a strongly dipolar coupled four qubit system.

  18. HUBBLE SPIES HUGE CLUSTERS OF STARS FORMED

    Science.gov (United States)

    2002-01-01

    BY ANCIENT ENCOUNTER This stunningly beautiful image [right] taken with the NASA Hubble Space Telescope shows the heart of the prototypical starburst galaxy M82. The ongoing violent star formation due to an ancient encounter with its large galactic neighbor, M81, gives this galaxy its disturbed appearance. The smaller picture at upper left shows the entire galaxy. The image was taken in December 1994 by the Kitt Peak National Observatory's 0.9-meter telescope. Hubble's view is represented by the white outline in the center. In the Hubble image, taken by the Wide Field and Planetary Camera 2, the huge lanes of dust that crisscross M82's disk are another telltale sign of the flurry of star formation. Below the center and to the right, a strong galactic wind is spewing knotty filaments of hydrogen and nitrogen gas. More than 100 super star clusters -- very bright, compact groupings of about 100,000 stars -- are seen in this detailed Hubble picture as white dots sprinkled throughout M82's central region. The dark region just above the center of the picture is a huge dust cloud. A collaboration of European and American scientists used these clusters to date the ancient interaction between M82 and M81. About 600 million years ago, a region called 'M82 B' (the bright area just below and to the left of the central dust cloud) exploded with new stars. Scientists have discovered that this ancient starburst was triggered by the violent encounter with M81. M82 is a bright (eighth magnitude), nearby (12 million light-years from Earth) galaxy in the constellation Ursa Major (the Great Bear). The Hubble picture was taken Sept. 15, 1997. The natural-color composite was constructed from three Wide Field and Planetary Camera 2 exposures, which were combined in chromatic order: 4,250 seconds through a blue filter (428 nm); 2,800 seconds through a green filter (520 nm); and 2,200 seconds through a red (820 nm) filter. Credits for Hubble image: NASA, ESA, R. de Grijs (Institute of

  19. The Space Shuttle Decision: NASA's Search for a Reusable Space Vehicle

    Science.gov (United States)

    Heppenheimer, T. A.

    1999-01-01

    This significant new study of the decision to build the Space Shuttle explains the Shuttle's origins and early development. In addition to internal NASA discussions, this work details the debates in the late 1960s and early 1970s among policymakers in Congress, the Air Force, and the Office of Management and Budget over the roles and technical designs of the Shuttle. Examining the interplay of these organizations with sometimes conflicting goals, the author not only explains how the world's premier space launch vehicle came into being, but also how politics can interact with science, technology, national security, and economics in national government. The weighty policy decision to build the Shuttle represents the first component of the broader story: future NASA volumes will cover the Shuttle's development and operational histories.

  20. Efficient and accurate nearest neighbor and closest pair search in high-dimensional space

    KAUST Repository

    Tao, Yufei

    2010-07-01

    Nearest Neighbor (NN) search in high-dimensional space is an important problem in many applications. From the database perspective, a good solution needs to have two properties: (i) it can be easily incorporated in a relational database, and (ii) its query cost should increase sublinearly with the dataset size, regardless of the data and query distributions. Locality-Sensitive Hashing (LSH) is a well-known methodology fulfilling both requirements, but its current implementations either incur expensive space and query cost, or abandon its theoretical guarantee on the quality of query results. Motivated by this, we improve LSH by proposing an access method called the Locality-Sensitive B-tree (LSB-tree) to enable fast, accurate, high-dimensional NN search in relational databases. The combination of several LSB-trees forms a LSB-forest that has strong quality guarantees, but improves dramatically the efficiency of the previous LSH implementation having the same guarantees. In practice, the LSB-tree itself is also an effective index which consumes linear space, supports efficient updates, and provides accurate query results. In our experiments, the LSB-tree was faster than: (i) iDistance (a famous technique for exact NN search) by two orders ofmagnitude, and (ii) MedRank (a recent approximate method with nontrivial quality guarantees) by one order of magnitude, and meanwhile returned much better results. As a second step, we extend our LSB technique to solve another classic problem, called Closest Pair (CP) search, in high-dimensional space. The long-term challenge for this problem has been to achieve subquadratic running time at very high dimensionalities, which fails most of the existing solutions. We show that, using a LSB-forest, CP search can be accomplished in (worst-case) time significantly lower than the quadratic complexity, yet still ensuring very good quality. In practice, accurate answers can be found using just two LSB-trees, thus giving a substantial

  1. Integrating space and time in visual search: how the preview benefit is modulated by stereoscopic depth.

    Science.gov (United States)

    Dent, Kevin; Braithwaite, Jason J; He, Xun; Humphreys, Glyn W

    2012-07-15

    We examined visual search for letters that were distributed across both 3 dimensional space, and time. In Experiment 1, when participants had foreknowledge of the depth plane and time interval where targets could appear, search was more efficient if the items could be segmented either by depth or by time (with a 1000 ms preview), and there were increased benefits when the two cues (depth and time) were combined. In Experiments 2 and 3 the target depth plane was always unknown to the participant. In this case, depth cues alone did not facilitate search, though they continued to increase the preview benefit. In Experiment 4 new items in preview search could fall at the same depth as preview items or a new depth. There was a substantial cost to search if the target appeared at a previewed depth. Experiment 5 showed that this cost remained even when participants knew the target would appear at the old depth on 75% of trials. The results indicate that spatial (depth) and temporal cues combine to enhance visual segmentation and selection, and this is accomplished by inhibition of distractors in irrelevant depth planes.

  2. Learning Problem-Solving Rules as Search Through a Hypothesis Space.

    Science.gov (United States)

    Lee, Hee Seung; Betts, Shawn; Anderson, John R

    2016-07-01

    Learning to solve a class of problems can be characterized as a search through a space of hypotheses about the rules for solving these problems. A series of four experiments studied how different learning conditions affected the search among hypotheses about the solution rule for a simple computational problem. Experiment 1 showed that a problem property such as computational difficulty of the rules biased the search process and so affected learning. Experiment 2 examined the impact of examples as instructional tools and found that their effectiveness was determined by whether they uniquely pointed to the correct rule. Experiment 3 compared verbal directions with examples and found that both could guide search. The final experiment tried to improve learning by using more explicit verbal directions or by adding scaffolding to the example. While both manipulations improved learning, learning still took the form of a search through a hypothesis space of possible rules. We describe a model that embodies two assumptions: (1) the instruction can bias the rules participants hypothesize rather than directly be encoded into a rule; (2) participants do not have memory for past wrong hypotheses and are likely to retry them. These assumptions are realized in a Markov model that fits all the data by estimating two sets of probabilities. First, the learning condition induced one set of Start probabilities of trying various rules. Second, should this first hypothesis prove wrong, the learning condition induced a second set of Choice probabilities of considering various rules. These findings broaden our understanding of effective instruction and provide implications for instructional design.

  3. Similarity searching and scaffold hopping in synthetically accessible combinatorial chemistry spaces.

    Science.gov (United States)

    Boehm, Markus; Wu, Tong-Ying; Claussen, Holger; Lemmen, Christian

    2008-04-24

    Large collections of combinatorial libraries are an integral element in today's pharmaceutical industry. It is of great interest to perform similarity searches against all virtual compounds that are synthetically accessible by any such library. Here we describe the successful application of a new software tool CoLibri on 358 combinatorial libraries based on validated reaction protocols to create a single chemistry space containing over 10 (12) possible products. Similarity searching with FTrees-FS allows the systematic exploration of this space without the need to enumerate all product structures. The search result is a set of virtual hits which are synthetically accessible by one or more of the existing reaction protocols. Grouping these virtual hits by their synthetic protocols allows the rapid design and synthesis of multiple follow-up libraries. Such library ideas support hit-to-lead design efforts for tasks like follow-up from high-throughput screening hits or scaffold hopping from one hit to another attractive series.

  4. Target-distractor similarity has a larger impact on visual search in school-age children than spacing.

    Science.gov (United States)

    Huurneman, Bianca; Boonstra, F Nienke

    2015-01-22

    In typically developing children, crowding decreases with increasing age. The influence of target-distractor similarity with respect to orientation and element spacing on visual search performance was investigated in 29 school-age children with normal vision (4- to 6-year-olds [N = 16], 7- to 8-year-olds [N = 13]). Children were instructed to search for a target E among distractor Es (feature search: all flanking Es pointing right; conjunction search: flankers in three orientations). Orientation of the target was manipulated in four directions: right (target absent), left (inversed), up, and down (vertical). Spacing was varied in four steps: 0.04°, 0.5°, 1°, and 2°. During feature search, high target-distractor similarity had a stronger impact on performance than spacing: Orientation affected accuracy until spacing was 1°, and spacing only influenced accuracy for identifying inversed targets. Spatial analyses showed that orientation affected oculomotor strategy: Children made more fixations in the "inversed" target area (4.6) than the vertical target areas (1.8 and 1.9). Furthermore, age groups differed in fixation duration: 4- to 6-year-old children showed longer fixation durations than 7- to 8-year-olds at the two largest element spacings (p = 0.039 and p = 0.027). Conjunction search performance was unaffected by spacing. Four conclusions can be drawn from this study: (a) Target-distractor similarity governs visual search performance in school-age children, (b) children make more fixations in target areas when target-distractor similarity is high, (c) 4- to 6-year-olds show longer fixation durations than 7- to 8-year-olds at 1° and 2° element spacing, and (d) spacing affects feature but not conjunction search-a finding that might indicate top-down control ameliorates crowding in children.

  5. Outcome of Hepatectomy for Huge Hepatocellular Carcinoma.

    Science.gov (United States)

    Jo, Sungho

    2011-05-01

    In spite of the recent improved results of hepatectomy for huge hepatocellular carcinomas (HCC), the prognosis of patients with huge HCCs is still poor compared to that of patients with small HCCs. This study was performed to compare the results of hepatectomy between patients with huge HCCs and those with small HCCs, to identify the prognostic factors in patients with huge HCCs, and to determine the preoperative selection criteria. We retrospectively analyzed 51 patients who underwent hepatectomy, between July 1994 and February 2009 at Dankook University Hospital. Patients with HCC≥10 cm were classified in large (L) group and others were classified in small (S) group. The clinicopathological features, operative procedures, and postoperative outcome were compared between both groups and various prognostic factors were investigated in group L. Eleven patients were classified in group L. Tumor size, vascular invasion, and tumor stage were higher in group L. Postoperative morbidity was higher in group L, but mortality was not different between the groups. Disease-free survivals were significantly lower in group L than in group S (36.4%, and 24.2% vs. 72.0%, and 44.0% for 1- and 3-year), but overall survival rates were similar in both groups (45.5%, and 15.2% in group L vs. 60.3%, and 41.3% in group S for 3- and 5-year). Presence of satellite nodules was the only prognostic factor in multivariate analysis after surgery for huge HCC. Regardless of tumor size, huge HCCs deserve consideration for surgery in patients with preserved liver function. Furthermore, the effect of surgery could be maximized with appropriate selection criteria, such as huge HCC without satellite nodules.

  6. Fast Exact Search in Hamming Space With Multi-Index Hashing.

    Science.gov (United States)

    Norouzi, Mohammad; Punjani, Ali; Fleet, David J

    2014-06-01

    There is growing interest in representing image data and feature descriptors using compact binary codes for fast near neighbor search. Although binary codes are motivated by their use as direct indices (addresses) into a hash table, codes longer than 32 bits are not being used as such, as it was thought to be ineffective. We introduce a rigorous way to build multiple hash tables on binary code substrings that enables exact k-nearest neighbor search in Hamming space. The approach is storage efficient and straight-forward to implement. Theoretical analysis shows that the algorithm exhibits sub-linear run-time behavior for uniformly distributed codes. Empirical results show dramatic speedups over a linear scan baseline for datasets of up to one billion codes of 64, 128, or 256 bits.

  7. Joint DOA and time delay estimation method for space-time coherent distributed signals based on search

    Institute of Scientific and Technical Information of China (English)

    Qian Bin; Yang Wanlin; Wan Qun

    2007-01-01

    Under dense urban fading environment, performance of joint multi-path parameter estimation method based on traditional point signal model degrades seriously.In this paper, a new space and time signal model based on multipath distribution function is given after new space and time manifold is reconstructed.Then joint spacetime signal subspace is obtained by converting acquired channel from time domain to frequency domain .Then space and time spectrum is formulated by the space sub-matrix and time sub-matrix taken out of joint space-time signal subspace, and parameters are estimated by searching the minimum eigenvalues of the space matrix and the time matrix.Lastly, A space and time parameters matching process is performed by using the orthogonal property between joint noise subspace and the space-time manifold.In contrast with tradition MUSIC, the algorithm we present here only need two 1- dimension searching and was not sensitive to different distribution function.

  8. Modeling State Space Search Technique for a Real World Adversarial Problem Solving

    Directory of Open Access Journals (Sweden)

    Kester O. Omoregie

    2015-02-01

    Full Text Available In problem solving, there is a search for the appropriate solution. A state space is a problem domain consisting of the start state, the goal state and the operations that will necessitate the various moves from the start state to the goal state. Each move operation takes one away from the start state and closer to the goal state. In this work we have attempted implementing this concept in adversarial problem solving, which is a more complex problem space. We noted that real world adversarial problems vary in their types and complexities, and therefore solving an adversarial problem would depend on the nature of the adversarial problem itself. Specifically, we examined a real world case, "the prisoner's dilemma" which is a critical, mutually independent, decision making adversarial problem. We combined the idea of the Thagard's Theory of Explanatory Coherence (TEC with Bayes' theorem of conditional probability to construct the model of an opponent that includes the opponent's model of the agent. A further conversion of the model into a series of state space structures led us into the use of breadth-first search strategy to arrive at our decision goal.

  9. Searching for transition paths in multidimensional space with a fixed repulsive bias potential

    Science.gov (United States)

    Trushin, O. S.; Salo, P.; Ala-Nissila, T.; Ying, S. C.

    2004-01-01

    An efficient method for searching for transition paths in a multidimensional configuration space is proposed. It is based on using a fixed, locally repulsive bias potential, which forces the system to move from a given initial state to a different final state. This simple method is very effective in determining nearby configurations and possible transition paths for many-particle systems. Once the approximate transition paths are known, the corresponding activation energies can be computed using, e.g., the nudged elastic band method. The usefulness of the present method is demonstrated for both classical and quantum-mechanical systems.

  10. Self-Organized Resonance during Search of a Diverse Chemical Space

    Science.gov (United States)

    Kachman, Tal; Owen, Jeremy A.; England, Jeremy L.

    2017-07-01

    Recent studies of active matter have stimulated interest in the driven self-assembly of complex structures. Phenomenological modeling of particular examples has yielded insight, but general thermodynamic principles unifying the rich diversity of behaviors observed have been elusive. Here, we study the stochastic search of a toy chemical space by a collection of reacting Brownian particles subject to periodic forcing. We observe the emergence of an adaptive resonance in the system matched to the drive frequency, and show that the increased work absorption by these resonant structures is key to their stabilization. Our findings are consistent with a recently proposed thermodynamic mechanism for far-from-equilibrium self-organization.

  11. Search of wormholes in different dimensional non-commutative inspired space-time with lorentzian distribution

    CERN Document Server

    Bhar, Piyali

    2014-01-01

    In this paper we are interested to search whether wormhole solutions exists in different dimensional noncommutative inspired spacetime.It is well known that noncommutativity of the space is an outcome of the string theory and it replaced the usual point like object by a smeared object.Here we have chosen Lorentzian distribution as the density function in the noncommutative inspired spacetime.We have observed that the wormhole solution exists only in four and five dimension,however higher than five dimension no wormhole exists.

  12. The Antarctic Search for Meteorites: The Future of Space, on Earth Today - EVA Knowledge Capture Outbrief

    Science.gov (United States)

    Love, Stan

    2013-01-01

    NASA astronaut Stan Love shared his experiences with the Antarctic Search for Meteorites (ANSMET), an annual expedition to the southern continent to collect valuable samples for research in planetary science. ANSMET teams operate from isolated, remote field camps on the polar plateau, where windchill factors often reach -40 F. Several astronaut participants have noted ANSMET's similarity to a space mission. Some of the operational concepts, tools, and equipment employed by ANSMET teams may offer valuable insights to designers of future planetary surface exploration hardware.

  13. Connecting slow earthquakes to huge earthquakes.

    Science.gov (United States)

    Obara, Kazushige; Kato, Aitaro

    2016-07-15

    Slow earthquakes are characterized by a wide spectrum of fault slip behaviors and seismic radiation patterns that differ from those of traditional earthquakes. However, slow earthquakes and huge megathrust earthquakes can have common slip mechanisms and are located in neighboring regions of the seismogenic zone. The frequent occurrence of slow earthquakes may help to reveal the physics underlying megathrust events as useful analogs. Slow earthquakes may function as stress meters because of their high sensitivity to stress changes in the seismogenic zone. Episodic stress transfer to megathrust source faults leads to an increased probability of triggering huge earthquakes if the adjacent locked region is critically loaded. Careful and precise monitoring of slow earthquakes may provide new information on the likelihood of impending huge earthquakes.

  14. Connecting slow earthquakes to huge earthquakes

    Science.gov (United States)

    Obara, Kazushige; Kato, Aitaro

    2016-07-01

    Slow earthquakes are characterized by a wide spectrum of fault slip behaviors and seismic radiation patterns that differ from those of traditional earthquakes. However, slow earthquakes and huge megathrust earthquakes can have common slip mechanisms and are located in neighboring regions of the seismogenic zone. The frequent occurrence of slow earthquakes may help to reveal the physics underlying megathrust events as useful analogs. Slow earthquakes may function as stress meters because of their high sensitivity to stress changes in the seismogenic zone. Episodic stress transfer to megathrust source faults leads to an increased probability of triggering huge earthquakes if the adjacent locked region is critically loaded. Careful and precise monitoring of slow earthquakes may provide new information on the likelihood of impending huge earthquakes.

  15. Treatment strategies for huge central neurocytomas.

    Science.gov (United States)

    Xiong, Zhong-wei; Zhang, Jian-jian; Zhang, Ting-bao; Sun, Shou-jia; Wu, Xiao-lin; Wang, Hao; You, Chao; Wang, Yu; Zhang, Hua-qiu; Chen, Jin-cao

    2015-02-01

    Central neurocytomas (CNs), initially asymptomatic, sometimes become huge before detection. We described and analyzed the clinical, radiological, operational and outcome data of 13 cases of huge intraventricular CNs, and discussed the treatment strategies in this study. All huge CNs (n=13) in our study were located in bilateral lateral ventricle with diameter ≥5.0 cm and had a broad-based attachment to at least one side of the ventricle wall. All patients received craniotomy to remove the tumor through transcallosal or transcortical approach and CNs were of typical histologic and immunohistochemical features. Adjuvant therapies including conventional radiation therapy (RT) or gamma knife radiosurgery (GKRS) were also performed postoperatively. Transcallosal and transcortical approaches were used in 8 and 5 patients, respectively. Two patients died within one month after operation and 3 patients with gross total resection (GTR) were additionally given a decompressive craniectomy (DC) and/or ventriculoperitoneal shunt (VPS) as the salvage therapy. Six patients received GTR(+RT) and 7 patients received subtotal resection (STR)(+GKRS). Eight patients suffered serious complications such as hydrocephalus, paralysis and seizure after operation, and patients who underwent GTR showed worse functional outcome [less Karnofsky performance scale (KPS) scores] than those having STR(+GKRS) during the follow-up period. The clinical outcome of huge CNs seemed not to be favorable as that described in previous reports. Surgical resection for huge CNs should be meticulously considered to guarantee the maximum safety. Better results were achieved in STR(+GKRS) compared with GTR(+RT) for huge CNs, suggesting that STR(+GKRS) may be a better treatment choice. The recurrent or residual tumor can be treated with GKRS effectively.

  16. Exploration an the Search for Origins: A Vision for Ultraviolet-Optical-Infrared Space Astronomy

    Science.gov (United States)

    Dressler, Alan (Editor); Brown, Robert A.; Davidsen, Arthur F.; Ellis, Richard S.; Freedman, Wendy L.; Green, Richard F.; Hauser, Michael G.; Kirshner, Robert P.; Kulkarni, Shrinivas; Lilly, Simon J.; Margon, Bruce H.; Porco, Carolyn C.; Richstone, Douglas O.; Stockman, H. S.; Thronson, Harley A., Jr.; Tonry, John L.; Truran, James; Weiler, Edward J.

    1996-01-01

    Public support and enthusiasm for astronomy have been strong in the final decades of the twentieth century. Nowhere is this better demonstrated than with the Hubble Space Telescope (HCT), a grand endeavor, which is enabling astronomers to make giant strides in understanding our universe, our place in it, and our relation to it. The NASAs first infrared observatory, the Space Infrared Telescope Facility (SIRTF), promises to take the crucial next steps towards understanding the formation of stars and galaxies. Toward their completion, the HST and Beyond Committee identifies major goals, whose accomplishment will justify a commitment well into the next century: (1) the detailed study of the birth and evolution of normal galaxies such as the Milky Way; (2) the detection of Earth-like planets around other stars and the search for evidence of life on them; (3) NASA should develop a space observatory of aperture 4m or larger, optimized for imaging and spectroscopy over the wavelength range 1-5 microns; and (4) NASA should develop the capability for space interferometry.

  17. SiMPSON: Efficient Similarity Search in Metric Spaces over P2P Structured Overlay Networks

    Science.gov (United States)

    Vu, Quang Hieu; Lupu, Mihai; Wu, Sai

    Similarity search in metric spaces over centralized systems has been significantly studied in the database research community. However, not so much work has been done in the context of P2P networks. This paper introduces SiMPSON: a P2P system supporting similarity search in metric spaces. The aim is to answer queries faster and using less resources than existing systems. For this, each peer first clusters its own data using any off-the-shelf clustering algorithms. Then, the resulting clusters are mapped to one-dimensional values. Finally, these one-dimensional values are indexed into a structured P2P overlay. Our method slightly increases the indexing overhead, but allows us to greatly reduce the number of peers and messages involved in query processing: we trade a small amount of overhead in the data publishing process for a substantial reduction of costs in the querying phase. Based on this architecture, we propose algorithms for processing range and kNN queries. Extensive experimental results validate the claims of efficiency and effectiveness of SiMPSON.

  18. A Huge Ancient Schwannoma of the Epiglottis.

    Science.gov (United States)

    Lee, Dong Hoon; Kim, Jo Heon; Yoon, Tae Mi; Lee, Joon Kyoo; Lim, Sang Chul

    2016-03-01

    Ancient schwannoma of the epiglottis is extremely rare. The authors report the first case of a patient with a huge ancient schwannoma of the epiglottis. Clinicians should consider the possibility that ancient schwannoma may originate in the epiglottis mimicking the other more frequently observed lesions.

  19. A huge presacral Tarlov cyst. Case report.

    Science.gov (United States)

    Ishii, Kazuhiko; Yuzurihara, Masahito; Asamoto, Shunji; Doi, Hiroshi; Kubota, Motoo

    2007-08-01

    Perineural cysts have become a common incidental finding during lumbosacral magnetic resonance (MR) imaging. Only some of the symptomatic cysts warrant treatment. The authors describe the successful operative treatment of a patient with, to the best of their knowledge, the largest perineural cyst reported to date. A 29-year-old woman had been suffering from long-standing constipation and low-back pain. During an obstetric investigation for infertility, the clinician discovered a huge presacral cystic mass. Computed tomography myelography showed the lesion to be a huge Tarlov cyst arising from the left S-3 nerve root and compressing the ipsilateral S-2 nerve. The cyst was successfully treated by ligation of the cyst neck together with sectioning of the S-3 nerve root. Postoperative improvement in her symptoms and MR imaging findings were noted. Identification of the nerve root involved by the cyst wall, operative indication, operative procedure, and treatment of multiple cysts are important preoperative considerations.

  20. Searching for Possible Siblings of the Sun from a Common Cluster based on Stellar Space Velocities

    CERN Document Server

    Bobylev, V V; Myllari, A; Valtonen, M; 10.1134/S0320010811070011

    2011-01-01

    We propose a kinematic approach to searching for the stars that could be formed with the Sun in a common "parent" open cluster. The approach consists in preselecting suitable candidates by the closeness of their space velocities to the solar velocity and analyzing the parameters of their encounters with the solar orbit in the past in a time interval comparable to the lifetime of stars. We consider stars from the Hipparcos catalog with available radial velocities. The Galactic orbits of stars have been constructed in the Allen--Santillan potential by taking into account the perturbations from the spiral density wave. We show that two stars, HIP 87382 and HIP 47399, are of considerable interest in our problem. Their orbits oscillate near the solar orbit with an amplitude of about 250 pc; there are short-term close encounters to distances <10 pc. Both stars have an evolutionary status and metallicity similar to the solar ones.

  1. A fast approximate nearest neighbor search algorithm in the Hamming space.

    Science.gov (United States)

    Esmaeili, Mani Malek; Ward, Rabab Kreidieh; Fatourechi, Mehrdad

    2012-12-01

    A fast approximate nearest neighbor search algorithm for the (binary) Hamming space is proposed. The proposed Error Weighted Hashing (EWH) algorithm is up to 20 times faster than the popular locality sensitive hashing (LSH) algorithm and works well even for large nearest neighbor distances where LSH fails. EWH significantly reduces the number of candidate nearest neighbors by weighing them based on the difference between their hash vectors. EWH can be used for multimedia retrieval and copy detection systems that are based on binary fingerprinting. On a fingerprint database with more than 1,000 videos, for a specific detection accuracy, we demonstrate that EWH is more than 10 times faster than LSH. For the same retrieval time, we show that EWH has a significantly better detection accuracy with a 15 times lower error rate.

  2. Implications of LHC searches on SUSY particle spectra. The pMSSM parameter space with neutralino dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Arbey, A. [Universite de Lyon, Universite Lyon 1, Villeurbanne Cedex (France); CERN, Geneva 23 (Switzerland); Ecole Normale Superieure de Lyon, Observatoire de Lyon, CNRS, UMR5574 CRAL, Saint-Genis Laval Cedex (France); Battaglia, M. [CERN, Geneva 23 (Switzerland); University of California, Santa Cruz Institute of Particle Physics, Santa Cruz, CA (United States); Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Mahmoudi, F. [CERN, Geneva 23 (Switzerland); Clermont Universite, Universite Blaise Pascal, CNRS/IN2P3, LPC, BP 10448, Clermont-Ferrand (France)

    2012-01-15

    We study the implications of LHC searches on SUSY particle spectra using flat scans of the 19-parameter pMSSM phase space. We apply constraints from flavour physics, g{sub {mu}} -2, dark matter and earlier LEP and Tevatron searches. The sensitivity of the LHC SUSY searches with jets, leptons and missing energy is assessed by reproducing with fast simulation the recent CMS analyses after validation on benchmark points. We present results in terms of the fraction of pMSSM points compatible with all the constraints which are excluded by the LHC searches with 1 fb {sup -1} and 15 fb {sup -1} as a function of the mass of strongly and weakly interacting SUSY particles. We also discuss the suppression of Higgs production cross sections for the MSSM points not excluded and contrast the region of parameter space tested by the LHC data with the constraints from dark matter direct detection experiments. (orig.)

  3. Template-space metric for searches for gravitational waves from the inspiral, merger and ringdown of binary black holes

    CERN Document Server

    Kalaghatgi, Chinmay; Arun, K G

    2015-01-01

    Searches for gravitational waves (GWs) from binary black holes using interferometric GW detectors require the construction of template banks for performing matched filtering while analyzing the data. Placement of templates over the parameter space of binaries, as well as coincidence tests of GW triggers from multiple detectors make use of the definition of a metric over the space of gravitational waveforms. Although recent searches have employed waveform templates coherently describing the inspiral, merger and ringdown (IMR) of the coalescence, the metric used in the template banks and coincidence tests was derived from post-Newtonian inspiral waveforms. In this paper, we compute the template-space metric of the IMR waveform family IMRPhenomB over the parameter space of masses and the effective spin parameter. We also propose a coordinate system, which is a modified version of post-Newtonian chirp time coordinates, in which the metric is slowly varying over the parameter space. The match function analytically...

  4. Development and evaluation of a biomedical search engine using a predicate-based vector space model.

    Science.gov (United States)

    Kwak, Myungjae; Leroy, Gondy; Martinez, Jesse D; Harwell, Jeffrey

    2013-10-01

    Although biomedical information available in articles and patents is increasing exponentially, we continue to rely on the same information retrieval methods and use very few keywords to search millions of documents. We are developing a fundamentally different approach for finding much more precise and complete information with a single query using predicates instead of keywords for both query and document representation. Predicates are triples that are more complex datastructures than keywords and contain more structured information. To make optimal use of them, we developed a new predicate-based vector space model and query-document similarity function with adjusted tf-idf and boost function. Using a test bed of 107,367 PubMed abstracts, we evaluated the first essential function: retrieving information. Cancer researchers provided 20 realistic queries, for which the top 15 abstracts were retrieved using a predicate-based (new) and keyword-based (baseline) approach. Each abstract was evaluated, double-blind, by cancer researchers on a 0-5 point scale to calculate precision (0 versus higher) and relevance (0-5 score). Precision was significantly higher (psearching than keywords, laying the foundation for rich and sophisticated information search.

  5. A trust-based sensor allocation algorithm in cooperative space search problems

    Science.gov (United States)

    Shen, Dan; Chen, Genshe; Pham, Khanh; Blasch, Erik

    2011-06-01

    Sensor allocation is an important and challenging problem within the field of multi-agent systems. The sensor allocation problem involves deciding how to assign a number of targets or cells to a set of agents according to some allocation protocol. Generally, in order to make efficient allocations, we need to design mechanisms that consider both the task performers' costs for the service and the associated probability of success (POS). In our problem, the costs are the used sensor resource, and the POS is the target tracking performance. Usually, POS may be perceived differently by different agents because they typically have different standards or means of evaluating the performance of their counterparts (other sensors in the search and tracking problem). Given this, we turn to the notion of trust to capture such subjective perceptions. In our approach, we develop a trust model to construct a novel mechanism that motivates sensor agents to limit their greediness or selfishness. Then we model the sensor allocation optimization problem with trust-in-loop negotiation game and solve it using a sub-game perfect equilibrium. Numerical simulations are performed to demonstrate the trust-based sensor allocation algorithm in cooperative space situation awareness (SSA) search problems.

  6. From tiny microalgae to huge biorefineries

    OpenAIRE

    Gouveia, L.

    2014-01-01

    Microalgae are an emerging research field due to their high potential as a source of several biofuels in addition to the fact that they have a high-nutritional value and contain compounds that have health benefits. They are also highly used for water stream bioremediation and carbon dioxide mitigation. Therefore, the tiny microalgae could lead to a huge source of compounds and products, giving a good example of a real biorefinery approach. This work shows and presents examples of experimental...

  7. A rare clinic entity: Huge trichobezoar

    Directory of Open Access Journals (Sweden)

    Hidayatullah Hamidi, Dr, MD

    2016-01-01

    Conclusion: Trichobezoars should be suspected in young females with long standing upper abdominal masses; as the possibility of malignancy is not very common in this age group. While USG is inconclusive, trichobezoar can be accurately diagnosed with CT. In patient with huge trichobezoar, laparotomy can be performed firstly because of big size and location of mass, and psychiatric recommendation should be made to prevent relapse of this entity.

  8. Robot-assisted laparoscopic resection of a huge pelvic tumor: A case report.

    Science.gov (United States)

    Jia, Zhuomin; Lyu, Xiangjun; Xu, Yong; Leonardi, Rosario; Zhang, Xu

    2016-07-04

    The traditional open surgery, for the treatment of huge tumor in the narrow space of pelvic cavity and in close proximity to pelvic organs and neurovascular structures, is very difficult and challenging. We report a case of huge neurilemmoma operated using the robot-assisted laparoscopy. We used interventional pre-operation embolization to control blood supply of tumor because MRI showed the tumor had a sufficient blood supply.

  9. Searching the Sequence Space for Potent Aptamers Using SELEX in Silico.

    Science.gov (United States)

    Zhou, Qingtong; Xia, Xiaole; Luo, Zhaofeng; Liang, Haojun; Shakhnovich, Eugene

    2015-12-08

    To isolate functional nucleic acids that bind to defined targets with high affinity and specificity, which are known as aptamers, the systematic evolution of ligands by exponential enrichment (SELEX) methodology has emerged as the preferred approach. Here, we propose a computational approach, SELEX in silico, that allows the sequence space to be more thoroughly explored regarding binding of a certain target. Our approach consists of two steps: (i) secondary structure-based sequence screening, which aims to collect the sequences that can form a desired RNA motif as an enhanced initial library, followed by (ii) sequence enrichment regarding target binding by molecular dynamics simulation-based virtual screening. Our SELEX in silico method provided a practical computational solution to three key problems in aptamer sequence searching: design of nucleic acid libraries, knowledge of sequence enrichment, and identification of potent aptamers. Six potent theophylline-binding aptamers, which were isolated by SELEX in silico from a sequence space containing 4(13) sequences, were experimentally verified to bind theophylline with high affinity: Kd ranging from 0.16 to 0.52 μM, compared with the dissociation constant of the original aptamer-theophylline, 0.32 μM. These results demonstrate the significant potential of SELEX in silico as a new method for aptamer discovery and optimization.

  10. KDTREE 2: Fortran 95 and C++ software to efficiently search for near neighbors in a multi-dimensional Euclidean space

    OpenAIRE

    Kennel, Matthew B.

    2004-01-01

    Many data-based statistical algorithms require that one find \\textit{near or nearest neighbors} to a given vector among a set of points in that vector space, usually with Euclidean topology. The k-d data structure and search algorithms are the generalization of classical binary search trees to higher dimensional spaces, so that one may locate near neighbors to an example vector in $O(\\log N)$ time instead of the brute-force O(N) time, with $N$ being the size of the data base. KDTREE2 is a For...

  11. GeneLab Phase 2: Integrated Search Data Federation of Space Biology Experimental Data

    Science.gov (United States)

    Tran, P. B.; Berrios, D. C.; Gurram, M. M.; Hashim, J. C. M.; Raghunandan, S.; Lin, S. Y.; Le, T. Q.; Heher, D. M.; Thai, H. T.; Welch, J. D.; hide

    2016-01-01

    The GeneLab project is a science initiative to maximize the scientific return of omics data collected from spaceflight and from ground simulations of microgravity and radiation experiments, supported by a data system for a public bioinformatics repository and collaborative analysis tools for these data. The mission of GeneLab is to maximize the utilization of the valuable biological research resources aboard the ISS by collecting genomic, transcriptomic, proteomic and metabolomic (so-called omics) data to enable the exploration of the molecular network responses of terrestrial biology to space environments using a systems biology approach. All GeneLab data are made available to a worldwide network of researchers through its open-access data system. GeneLab is currently being developed by NASA to support Open Science biomedical research in order to enable the human exploration of space and improve life on earth. Open access to Phase 1 of the GeneLab Data Systems (GLDS) was implemented in April 2015. Download volumes have grown steadily, mirroring the growth in curated space biology research data sets (61 as of June 2016), now exceeding 10 TB/month, with over 10,000 file downloads since the start of Phase 1. For the period April 2015 to May 2016, most frequently downloaded were data from studies of Mus musculus (39) followed closely by Arabidopsis thaliana (30), with the remaining downloads roughly equally split across 12 other organisms (each 10 of total downloads). GLDS Phase 2 is focusing on interoperability, supporting data federation, including integrated search capabilities, of GLDS-housed data sets with external data sources, such as gene expression data from NIHNCBIs Gene Expression Omnibus (GEO), proteomic data from EBIs PRIDE system, and metagenomic data from Argonne National Laboratory's MG-RAST. GEO and MG-RAST employ specifications for investigation metadata that are different from those used by the GLDS and PRIDE (e.g., ISA-Tab). The GLDS Phase 2 system

  12. Laparoscopic Management of Huge Cervical Myoma.

    Science.gov (United States)

    Peker, Nuri; Gündoğan, Savaş; Şendağ, Fatih

    To demonstrate the feasibility of laparoscopic management of a huge cervical myoma. Step-by-step video demonstration of the surgical procedure (Canadian Task Force classification III-C). Uterine myoma is the most common benign neoplasm of the female reproductive tract, with an estimated incidence of 25% to 30% at reproductive age [1,2]. Patients generally have no symptoms; however, those with such symptoms as severe pelvic pain, heavy uterine bleeding, or infertility may be candidates for surgery. The traditional management is surgery; however, uterine artery embolization or hormonal therapy using a gonadotropin-releasing hormone agonist or a selective estrogen receptor modulator should be preferred as the medical approach. Surgical management should be performed via laparoscopy or laparotomy; however, the use of laparoscopic myomectomy is being debated for patients with huge myomas. Difficulties in the excision, removal, and repair of myometrial defects, increased operative time, and blood loss are factors keeping physicians away from laparoscopic myomectomy [1,2]. A 40-year-old gravida 0, para 0 woman was admitted to our clinic with complaints of chronic pelvic pain, dyspareunia, and infertility. Her health history was unremarkable. Ultrasonographic examination revealed a 14 × 10-cm myoma in the cervical region. On bimanual examination, an immobile solid mass originating from the uterine cervix and filling the pouch of Douglas was palpated. The patient was informed of the findings, and laparoscopic myomectomy was recommended because of her desire to preserve her fertility. Abdominopelvic examination revealed a huge myoma filling and enlarging the cervix. Myomectomy was performed using standard technique as described elsewhere. A transverse incision was made using a harmonic scalpel. The myoma was fixed with a corkscrew manipulator and enucleated. Once bleeding was controlled, the myoma bed was filled with Spongostan to prevent possible bleeding from leakage

  13. Space-related pharma-motifs for fast search of protein binding motifs and polypharmacological targets.

    Science.gov (United States)

    Chiu, Yi-Yuan; Lin, Chun-Yu; Lin, Chih-Ta; Hsu, Kai-Cheng; Chang, Li-Zen; Yang, Jinn-Moon

    2012-01-01

    To discover a compound inhibiting multiple proteins (i.e. polypharmacological targets) is a new paradigm for the complex diseases (e.g. cancers and diabetes). In general, the polypharmacological proteins often share similar local binding environments and motifs. As the exponential growth of the number of protein structures, to find the similar structural binding motifs (pharma-motifs) is an emergency task for drug discovery (e.g. side effects and new uses for old drugs) and protein functions. We have developed a Space-Related Pharmamotifs (called SRPmotif) method to recognize the binding motifs by searching against protein structure database. SRPmotif is able to recognize conserved binding environments containing spatially discontinuous pharma-motifs which are often short conserved peptides with specific physico-chemical properties for protein functions. Among 356 pharma-motifs, 56.5% interacting residues are highly conserved. Experimental results indicate that 81.1% and 92.7% polypharmacological targets of each protein-ligand complex are annotated with same biological process (BP) and molecular function (MF) terms, respectively, based on Gene Ontology (GO). Our experimental results show that the identified pharma-motifs often consist of key residues in functional (active) sites and play the key roles for protein functions. The SRPmotif is available at http://gemdock.life.nctu.edu.tw/SRP/. SRPmotif is able to identify similar pharma-interfaces and pharma-motifs sharing similar binding environments for polypharmacological targets by rapidly searching against the protein structure database. Pharma-motifs describe the conservations of binding environments for drug discovery and protein functions. Additionally, these pharma-motifs provide the clues for discovering new sequence-based motifs to predict protein functions from protein sequence databases. We believe that SRPmotif is useful for elucidating protein functions and drug discovery.

  14. Target-distractor similarity has a larger impact on visual search in school-age children than spacing

    NARCIS (Netherlands)

    Huurneman, B.; Boonstra, F.N.

    2015-01-01

    In typically developing children, crowding decreases with increasing age. The influence of target-distractor similarity with respect to orientation and element spacing on visual search performance was investigated in 29 school-age children with normal vision (4- to 6-year-olds [N = 16], 7- to 8-year

  15. An efficient implementation of maximum likelihood identification of LTI state-space models by local gradient search

    NARCIS (Netherlands)

    Bergboer, N.H; Verdult, V.; Verhaegen, M.H.G.

    2002-01-01

    We present a numerically efficient implementation of the nonlinear least squares and maximum likelihood identification of multivariable linear time-invariant (LTI) state-space models. This implementation is based on a local parameterization of the system and a gradient search in the resulting parame

  16. Laparoscopic Management of Huge Myoma Nascendi.

    Science.gov (United States)

    Peker, Nuri; Gündoğan, Savas; Şendağ, Fatih

    To demonstrate the feasibility of laparoscopic management of a huge myoma nascendi. Step-by-step video demonstration of the surgical procedure (Canadian Task Force classification III-C). Uterine myoma is the most common benign neoplasm of the female reproductive tract, with an estimated incidence of 25% to 30% at reproductive age [1,2]. Patients generally have no symptoms; however, those with such symptoms as severe pelvic pain, heavy uterine bleeding, or infertility may be candidates for surgery. The traditional management is surgery; however, uterine artery embolization or hormonal therapy using a gonadotropin-releasing hormone agonist or a selective estrogen receptor modulator should be preferred as the medical approach. Surgical management should be performed via laparoscopy or laparotomy; however, the use of laparoscopic myomectomy is being debated for patients with huge myomas. Difficulties in the excision, removal, and repair of myometrial defects, increased operative time, and blood loss are factors keeping physicians away from laparoscopic myomectomy [1,2]. A 35-year-old woman was admitted to our clinic with complaints of chronic pelvic pain and heavy menstrual bleeding. Her medical history included multiple hospitalizations for blood transfusions, along with a recently measured hemoglobin level of 9.5 g/dL and a hematocrit value of 29%. She had never been married and had no children. Pelvic ultrasonography revealed a 12 × 10-cm uterine myoma located on the posterior side of the corpus uteri and protruding through to the cervical channel. This was a huge intramural submucous myoma in close proximity to the endometrial cavity and spreading through the myometrium. On vaginal examination, the myoma was found to extend into the vagina through the cervical channel. Laparoscopic myomectomy was planned because of the patient's desire for fertility preservation. Abdominopelvic exploration revealed a huge myoma filling the posterior side of the corpus uteri and

  17. Hubble Space Telescope search for the transit of the Earth-mass exoplanet Alpha Centauri Bb

    CERN Document Server

    Demory, Brice-Olivier; Queloz, Didier; Seager, Sara; Gilliland, Ronald; Chaplin, William J; Proffitt, Charles; Gillon, Michael; Guenther, Maximilian N; Benneke, Bjoern; Dumusque, Xavier; Lovis, Christophe; Pepe, Francesco; Segransan, Damien; Triaud, Amaury; Udry, Stephane

    2015-01-01

    Results from exoplanet surveys indicate that small planets (super-Earth size and below) are abundant in our Galaxy. However, little is known about their interiors and atmospheres. There is therefore a need to find small planets transiting bright stars, which would enable a detailed characterisation of this population of objects. We present the results of a search for the transit of the Earth-mass exoplanet Alpha Centauri Bb with the Hubble Space Telescope (HST). We observed Alpha Centauri B twice in 2013 and 2014 for a total of 40 hours. We achieve a precision of 115 ppm per 6-s exposure time in a highly-saturated regime, which is found to be consistent across HST orbits. We rule out the transiting nature of Alpha Centauri Bb with the orbital parameters published in the literature at 96.6% confidence. We find in our data a single transit-like event that could be associated to another Earth-size planet in the system, on a longer period orbit. Our program demonstrates the ability of HST to obtain consistent, hi...

  18. Reducing a Knowledge-Base Search Space When Data Are Missing

    Science.gov (United States)

    James, Mark

    2007-01-01

    This software addresses the problem of how to efficiently execute a knowledge base in the presence of missing data. Computationally, this is an exponentially expensive operation that without heuristics generates a search space of 1 + 2n possible scenarios, where n is the number of rules in the knowledge base. Even for a knowledge base of the most modest size, say 16 rules, it would produce 65,537 possible scenarios. The purpose of this software is to reduce the complexity of this operation to a more manageable size. The problem that this system solves is to develop an automated approach that can reason in the presence of missing data. This is a meta-reasoning capability that repeatedly calls a diagnostic engine/model to provide prognoses and prognosis tracking. In the big picture, the scenario generator takes as its input the current state of a system, including probabilistic information from Data Forecasting. Using model-based reasoning techniques, it returns an ordered list of fault scenarios that could be generated from the current state, i.e., the plausible future failure modes of the system as it presently stands. The scenario generator models a Potential Fault Scenario (PFS) as a black box, the input of which is a set of states tagged with priorities and the output of which is one or more potential fault scenarios tagged by a confidence factor. The results from the system are used by a model-based diagnostician to predict the future health of the monitored system.

  19. Huge Tongue Lipoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Damghani

    2015-03-01

    Full Text Available Introduction: Lipomas are among the most common tumors of the human body. However, they are uncommon in the oral cavity and are observed as slow growing, painless, and asymptomatic yellowish submucosal masses. Surgical excision is the treatment of choice and recurrence is not expected.    Case Report: The case of a 30-year-old woman with a huge lipoma on the tip of her tongue since 3 years, is presented. She had difficulty with speech and mastication because the tongue tumor was filling the oral cavity. Clinical examination revealed a yellowish lesion, measuring 8 cm in maximum diameter, protruding from the lingual surface. The tumor was surgically excised with restoration of normal tongue function and histopathological examination of the tumor confirmed that it was a lipoma.   Conclusion:  Tongue lipoma is rarely seen and can be a cause of macroglossia. Surgical excision for lipoma is indicated for symptomatic relief and exclusion of associated malignancy.

  20. A rare clinic entity: Huge trichobezoar.

    Science.gov (United States)

    Hamidi, Hidayatullah; Muhammadi, Marzia; Saberi, Bismillah; Sarwari, Mohammad Arif

    2016-01-01

    Trichobezoar is a rare clinical entity in which a ball of hair amasses within the alimentary tract. It can either be found as isolated mass in the stomach or may extend into the intestine. Trichobezoars mostly occur in young females with psychiatric disorders such as trichophagia and trichotillomania. Authors present a giant trichobezoar in an 18year old female presented with complaints of upper abdominal mass, epigastric area pain, anorexia and weight loss. The patient underwent trans-abdominal ultrasonography (USG), Computed tomography (CT), upper gastrointestinal endoscopy and subsequently laparotomy. USG was inconclusive due to non-specific findings. It revealed a thick echogenic layer with posterior dirty shadowing extending from the left sub-diaphragmatic area to the right sub hepatic region obscuring the adjacent structures. Abdominal CT images revealed a huge, well defined, multi-layered, heterogeneous, solid appearing, non-enhancing mass lesion in the gastric lumen extending from the gastric fundus to the pyloric canal. An endoscopic attempt was performed for removal of this intraluminal mass, but due to its large size, and hard nature, the endoscopic removal was unsuccessful. Finally the large trichobezoar was removed with open laparotomy. Trichobezoars should be suspected in young females with long standing upper abdominal masses; as the possibility of malignancy is not very common in this age group. While USG is inconclusive, trichobezoar can be accurately diagnosed with CT. In patient with huge trichobezoar, laparotomy can be performed firstly because of big size and location of mass, and psychiatric recommendation should be made to prevent relapse of this entity. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  1. Metaheuristics-Assisted Combinatorial Screening of Eu(2+)-Doped Ca-Sr-Ba-Li-Mg-Al-Si-Ge-N Compositional Space in Search of a Narrow-Band Green Emitting Phosphor and Density Functional Theory Calculations.

    Science.gov (United States)

    Lee, Jin-Woong; Singh, Satendra Pal; Kim, Minseuk; Hong, Sung Un; Park, Woon Bae; Sohn, Kee-Sun

    2017-08-21

    A metaheuristics-based design would be of great help in relieving the enormous experimental burdens faced during the combinatorial screening of a huge, multidimensional search space, while providing the same effect as total enumeration. In order to tackle the high-throughput powder processing complications and to secure practical phosphors, metaheuristics, an elitism-reinforced nondominated sorting genetic algorithm (NSGA-II), was employed in this study. The NSGA-II iteration targeted two objective functions. The first was to search for a higher emission efficacy. The second was to search for narrow-band green color emissions. The NSGA-II iteration finally converged on BaLi2Al2Si2N6:Eu(2+) phosphors in the Eu(2+)-doped Ca-Sr-Ba-Li-Mg-Al-Si-Ge-N compositional search space. The BaLi2Al2Si2N6:Eu(2+) phosphor, which was synthesized with no human intervention via the assistance of NSGA-II, was a clear single phase and gave an acceptable luminescence. The BaLi2Al2Si2N6:Eu(2+) phosphor as well as all other phosphors that appeared during the NSGA-II iterations were examined in detail by employing powder X-ray diffraction-based Rietveld refinement, X-ray absorption near edge structure, density functional theory calculation, and time-resolved photoluminescence. The thermodynamic stability and the band structure plausibility were confirmed, and more importantly a novel approach to the energy transfer analysis was also introduced for BaLi2Al2Si2N6:Eu(2+) phosphors.

  2. Searching the Future for the Legal Regime of Space Activities: the Need for Unification of National Space Legislation' Provisions

    Science.gov (United States)

    Negoda, S. A.

    2002-01-01

    space activities. For the future legal regime of space activities it is vital to preserve the existed principles and main provisions of the international space law. related legislations are developing rapidly. They become serious instrument for legal regulation of space activities. those projects with a foreign party involvement. Quite often partners in international space projects agree to choice a domestic law of one of them. They do this for defining a certain organizational and/or contractual issue (disputes settlement, for example) of the project. that such practice will spread widely. could help to preserve the existed important provisions of international space law (responsibility of states for their national activities, for instance). development of international space private law. We believe that solely special laws and regulations of national legislations could not regulate modern space activities. Being more and more commercial, space activities are becoming a real part of "downed to Earth" commercial activities. Therefore, in many countries provisions of civil, commercial, investment and other branches of national law are applied to such activities. which could low possible risks of such activities and to control them. Such unification seems to be suitable in the following fields: 1)implementation of provisions of international space law in national space laws; 2)definition of unified terminology, accepted by national laws of all parties; 3)unification in national legislations of a certain standards (insurance rates and rules, for instance); 4)unification in national laws of issues related to liability (for instance, a mutual wave of liability in certain types of 5)implementation in national laws of unified rules and procedures of space-related commercial disputes settlement; 6)unification of mechanisms for protection of space-related intellectual property. unification of their provisions. Special attention is paid to provisions of private law

  3. Households moving within the rental sector: mental schemata and search spaces

    OpenAIRE

    S C Aitken

    1987-01-01

    This paper is a report on a simultaneous study of renter movers' mental schemata, their overt search behaviour, and the structure of a housing submarket. Past research suggests that the pattern of intraurban migration can be rationalised using a model based upon an individual's mental image of the city. The mental image both facilitates search, and acts as a behavioural constraint upon the resident when he or she is searching for new accommodation. However, cognitive mapping per se has been l...

  4. On the beam direction search space in computerized non-coplanar beam angle optimization for IMRT-prostate SBRT.

    Science.gov (United States)

    Rossi, Linda; Breedveld, Sebastiaan; Heijmen, Ben J M; Voet, Peter W J; Lanconelli, Nico; Aluwini, Shafak

    2012-09-01

    In a recent paper, we have published a new algorithm, designated 'iCycle', for fully automated multi-criterial optimization of beam angles and intensity profiles. In this study, we have used this algorithm to investigate the relationship between plan quality and the extent of the beam direction search space, i.e. the set of candidate beam directions that may be selected for generating an optimal plan. For a group of ten prostate cancer patients, optimal IMRT plans were made for stereotactic body radiation therapy (SBRT), mimicking high dose rate brachytherapy dosimetry. Plans were generated for five different beam direction input sets: a coplanar (CP) set and four non-coplanar (NCP) sets. For CP treatments, the search space consisted of 72 orientations (5° separations). The NCP CyberKnife (CK) space contained all directions available in the robotic CK treatment unit. The fully non-coplanar (F-NCP) set facilitated the highest possible degree of freedom in selecting optimal directions. CK(+) and CK(++) were subsets of F-NCP to investigate some aspects of the CK space. For each input set, plans were generated with up to 30 selected beam directions. Generated plans were clinically acceptable, according to an assessment of our clinicians. Convergence in plan quality occurred only after around 20 included beams. For individual patients, variations in PTV dose delivery between the five generated plans were minimal, as aimed for (average spread in V(95): 0.4%). This allowed plan comparisons based on organ at risk (OAR) doses, with the rectum considered most important. Plans generated with the NCP search spaces had improved OAR sparing compared to the CP search space, especially for the rectum. OAR sparing was best with the F-NCP, with reductions in rectum D(Mean), V(40Gy), V(60Gy) and D(2%) compared to CP of 25%, 35%, 37% and 8%, respectively. Reduced rectum sparing with the CK search space compared to F-NCP could be largely compensated by expanding CK with beams with

  5. The Attentional Fields of Visual Search in Simultanagnosia and Healthy Individuals: How Object and Space Attention Interact.

    Science.gov (United States)

    Khan, A Z; Prost-Lefebvre, M; Salemme, R; Blohm, G; Rossetti, Y; Tilikete, C; Pisella, L

    2016-03-01

    Simultanagnosia is a deficit in which patients are unable to perceive multiple objects simultaneously. To date, it remains disputed whether this deficit results from disrupted object or space perception. We asked both healthy participants as well as a patient with simultanagnosia to perform different visual search tasks of variable difficulty. We also modulated the number of objects (target and distracters) presented. For healthy participants, we found that each visual search task was performed with a specific "attentional field" depending on the difficulty of visual object processing but not on the number of objects falling within this "working space." This was demonstrated by measuring the cost in reaction times using different gaze-contingent visible window sizes. We found that bilateral damage to the superior parietal lobule impairs the spatial integration of separable features (within-object processing), shrinking the attentional field in which a target can be detected, but causing no deficit in processing multiple objects per se.

  6. Empirically extending the range of validity of parameter-space metrics for all-sky searches for gravitational-wave pulsars

    CERN Document Server

    Wette, Karl

    2016-01-01

    All-sky searches for gravitational-wave pulsars are generally limited in sensitivity by the finite availability of computing resources. Semicoherent searches are a common method of maximizing search sensitivity given a fixed computing budget. The work of Wette and Prix [Phys. Rev. D 88, 123005 (2013)] and Wette [Phys. Rev. D 92, 082003 (2015)] developed a semicoherent search method which uses metrics to construct the banks of pulsar signal templates needed to search the parameter space of interest. In this work we extend the range of validity of the parameter-space metrics using an empirically-derived relationship between the resolution (or mismatch) of the template banks and the mismatch of the overall search. This work has important consequences for the optimization of metric-based semicoherent searches at fixed computing cost.

  7. Umbilicoplasty in children with huge umbilical hernia

    Directory of Open Access Journals (Sweden)

    Akakpo-Numado Gamedzi Komlatsè

    2014-01-01

    Full Text Available Background: Huge umbilical hernias (HUH are voluminous umbilical hernia (UH that are frequent in black African children. Several surgical techniques are used in their treatment for umbilical reconstruction, but techniques using skin flaps provide better aesthetic results. In this study, we presented our technique of umbilicoplasty in HUH, and its results. Patients and Methods: It is a retrospective study on children treated for HUH, from January 2012 to December 2013. The UH was called HUH when its basis diameter (BD exceeds 3 cm. Every HUH was characterised by its height, BD and morphology. Our technique was a two lateral flaps technique; the flaps are symmetrical and drawn so as to reconstitute the different parts of the umbilicus. The results were appreciated with criteria, including the peripheral ring and the central depression of the neo-umbilicus. Results : Twelve children were concerned (7 boys and 5 girls. Their mean age was 5 years and 6 months. The mean BD was 5.6 cm (extremes 3 and 8 cm, and the mean height of the HUH was 7.45 cm (extremes 3 and 9 cm. All underwent umbilicoplasty. In early post-operative period, two children presented a transitory subcutaneous hematoma. Late complications were granulation tissue with two children, and cheloid scar with one. With a mean follow-up of 10 months, we had 10 excellent results and two fair results according to our criteria. Conclusion: Our two lateral flaps umbilicoplasty is well-adapted to HUH in children. It is simple and assures a satisfactory anatomical and cosmetic result.

  8. Hepatectomy for huge hepatocellular carcinoma: single institute's experience.

    Science.gov (United States)

    Yang, Lianyue; Xu, Jiangfeng; Ou, Dipeng; Wu, Wei; Zeng, Zhijun

    2013-09-01

    The surgical resection of huge hepatocellular carcinoma (HCC) is still controversial. This study was designed to introduce our experience of liver resection for huge HCC and evaluate the safety and outcomes of hepatectomy for huge HCC. A total of 258 hepatic resections for the patients with huge HCC were analysed retrospectively from December 2002 to December 2011. The operative outcomes were compared with 293 patients with HCC >5.0 cm but huge HCC group and HCC >5.0 cm but huge HCC group has significantly a more longer overall and disease-free survival time than nodular huge HCC (P = 0.026, P = 0.022). Univariate and multivariate analysis revealed that the types of tumour, vascular invasion, and UICC stage were independent prognostic factors for overall survival (P = 0.047, P = 0.037, P = 0.033). Hepatic resection can be performed safely for huge HCC with a low mortality and favorable survival outcomes. Solitary huge HCC has the better surgical outcomes than nodular huge HCC.

  9. Nearest Neighbor Search in the Metric Space of a Complex Network for Community Detection

    Directory of Open Access Journals (Sweden)

    Suman Saha

    2016-03-01

    Full Text Available The objective of this article is to bridge the gap between two important research directions: (1 nearest neighbor search, which is a fundamental computational tool for large data analysis; and (2 complex network analysis, which deals with large real graphs but is generally studied via graph theoretic analysis or spectral analysis. In this article, we have studied the nearest neighbor search problem in a complex network by the development of a suitable notion of nearness. The computation of efficient nearest neighbor search among the nodes of a complex network using the metric tree and locality sensitive hashing (LSH are also studied and experimented. For evaluation of the proposed nearest neighbor search in a complex network, we applied it to a network community detection problem. Experiments are performed to verify the usefulness of nearness measures for the complex networks, the role of metric tree and LSH to compute fast and approximate node nearness and the the efficiency of community detection using nearest neighbor search. We observed that nearest neighbor between network nodes is a very efficient tool to explore better the community structure of the real networks. Several efficient approximation schemes are very useful for large networks, which hardly made any degradation of results, whereas they save lot of computational times, and nearest neighbor based community detection approach is very competitive in terms of efficiency and time.

  10. The chemist as astronaut: searching for biologically useful space in the chemical universe.

    Science.gov (United States)

    Triggle, David J

    2009-08-01

    Chemical space whether defined by small molecules or large proteins is larger than can be usefully explored. One of the challenges of drug discovery is thus the definition of the overlap between chemical space, biologically useful space and pharmacological space and how this may be employed in the discovery of new small molecule drugs. Despite the decrease in drug discovery productivity in recent years there is no shortage of targets for small molecule intervention, including stroke, pain, neurodegenerative diseases, inflammation and bacterial and viral infections. Only an extremely small fraction of available chemical space has thus far been explored and it is likely that prior synthetic constraints and bias to existing frameworks and scaffolds have contributed to this. Several approaches are being employed to explore more fruitful paths to discovery. These include recognition that existing therapeutic entities already occupy validated pharmacological space and thus are good leads, the use of molecular fragments that permits a broader exploration of chemical space, and the role of templates that permit fragments to combine to generate active species. Finally, a new focus on natural product-like scaffolds from both synthetic methodologies and the genetic reengineering of biosynthetic pathways is likely to prove valuable. However the exploration of chemical space will alone not solve the current deficit in drug discovery productivity. It is necessary to recognize that cellular environments are not the dilute homogeneous solutions of many screening systems and that a more integrated systems approach will serve to maximize any success of chemical space exploration.

  11. Robotic resection of huge presacral tumors: case series and comparison with an open resection.

    Science.gov (United States)

    Oh, Jae Keun; Yang, Moon Sool; Yoon, Do Heum; Rha, Koon Ho; Kim, Keung Nyun; Yi, Seong; Ha, Yoon

    2014-06-01

    Clinical case series and analysis. The purpose of the present study is to evaluate the advantages and disadvantages of robotic presacral tumor resection compared with conventional open approach. Conventional open approach for huge presacral tumors in the retroperitoneal space often demands excessive hospitalization and poor cosmesis. Furthermore, narrow surgical field sometimes interrupt delicate procedures. Nine patients with huge (diameter >10 cm) presacral tumors underwent surgery. Five patients among them had robotic procedure and the others had open transperitoneal tumor resection. Operation time, blood loss, hospitalization, and complications were analyzed. Robotic presacral tumor resection showed shorter operation time, less bleeding, and shorter hospitalization. Moreover, there was no complication related to abdominal adhesion. Although robotic resection for presacral tumor still has limitations technically and economically, robotic resection for huge presacral tumors demonstrated advantages over open resection specifically for benign neurogenic tumors.

  12. Solar cells in space. (Latest citations from the EI Compendex*plus database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    The bibliography contains citations concerning development, current applications, and potential uses of solar cells in outer space. Topics include design considerations and systems descriptions and evaluations. The use of solar cells to generate energy for electrical power in space is discussed. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  13. Effects of Link Annotations on Search Performance in Layered and Unlayered Hierarchically Organized Information Spaces.

    Science.gov (United States)

    Fraser, Landon; Locatis, Craig

    2001-01-01

    Investigated the effects of link annotations on high school user search performance in Web hypertext environments having deep (layered) and shallow link structures. Results confirmed previous research that shallow link structures are better than deep (layered) link structures, and also showed that annotations had virtually no effect on search…

  14. The Space Stellar Photometry Mission COROT: Asteroseismology and Search for Extrasolar Planets

    Indian Academy of Sciences (India)

    Annie Baglin; Gerard Vauclair; Corot team

    2000-09-01

    The main scientific objectives, asteroseismology and search for extrasolar planets for the COROT photometric mission are presented, and its interest in terms of stellar variability. A description of the payload, details of the scientific program, the ground based preparatory observations and bibliography can be found at http://www.astrsp-mrs.fr/corot/pagecorot.html.

  15. Data Transformation Functions for Expanded Search Spaces in Geographic Sample Supervised Segment Generation

    Directory of Open Access Journals (Sweden)

    Christoff Fourie

    2014-04-01

    Full Text Available Sample supervised image analysis, in particular sample supervised segment generation, shows promise as a methodological avenue applicable within Geographic Object-Based Image Analysis (GEOBIA. Segmentation is acknowledged as a constituent component within typically expansive image analysis processes. A general extension to the basic formulation of an empirical discrepancy measure directed segmentation algorithm parameter tuning approach is proposed. An expanded search landscape is defined, consisting not only of the segmentation algorithm parameters, but also of low-level, parameterized image processing functions. Such higher dimensional search landscapes potentially allow for achieving better segmentation accuracies. The proposed method is tested with a range of low-level image transformation functions and two segmentation algorithms. The general effectiveness of such an approach is demonstrated compared to a variant only optimising segmentation algorithm parameters. Further, it is shown that the resultant search landscapes obtained from combining mid- and low-level image processing parameter domains, in our problem contexts, are sufficiently complex to warrant the use of population based stochastic search methods. Interdependencies of these two parameter domains are also demonstrated, necessitating simultaneous optimization.

  16. In search of "the white area": some notes on art in clinical space.

    Science.gov (United States)

    Molad, Gershon J

    2004-03-01

    Would you consider looking at two paintings instead of reading a more ritualized abstract? In the first painting, the poet W. B. Yeats shows passages from his autobiography to his friend, the poet and painter George Russell. Russell is appalled to read that there is hardly a single fact accurate: "If you show me the manuscript," he tells Yeats, "I will correct the facts." Yeats airily dismisses the offer: "Oh, I do not want accuracy. I only want a picturesque sentence" (Kiberd, 2003). The second painting is an image I cherish in my mind for years: a photo of the Teatro del Mondo (the theater of the world) created by Aldo Rossi, the late Italian architect, for the 1979 Venice Biennale. Built in the Venice tradition of floating theaters, Rossi created a theater on water, a raft tugged by a boat. Within the panoramic view of Venice, there is a "huge piece of carpentry," which looks like a stageset of a child's dream memory: some big connected play-cubes made of light brown wood on a metal grid of scaffolding, and a blue pointed tower. For Rossi, this theater goes beyond the context of Venice. It is like "the Marine buildings in Maine, the wonderful tall light houses--'the houses of the light'--that observe and are observed...[in a] Venetian method of construction...that seeks fantasy only in the real" (Rossi, 1979).

  17. Combining Static Analysis and Case-Based Search Space Partitioning for Reducing Peak Memory in Model Checking

    Institute of Scientific and Technical Information of China (English)

    ZHANG WenHui (张文辉)

    2003-01-01

    Memory is one of the critical resources in model checking. This paper discusses a strategy for reducing peak memory in model checking by case-based partitioning of the search space. This strategy combines model checking for verification of different cases and static analysis or expert judgment for guaranteeing the completeness of the cases. Description of the static analysis is based on using PROMELA as the modeling language. The strategy is applicable to a subset of models including models for verification of certain aspects of protocols.

  18. A search for new MRI criteria for dissemination in space in subjects with a clinically isolated syndrome

    DEFF Research Database (Denmark)

    Korteweg, T; Tintore, M; Uitdehaag, B M J;

    2009-01-01

    The International Panel on the Diagnosis of Multiple Sclerosis (MS) incorporated the Barkhof/Tintoré (B/T) magnetic resonance criteria into their diagnostic scheme to provide evidence of dissemination in space of central nervous system lesions, a prerequisite for diagnosing MS in patients who...... in a search for simpler and more sensitive criteria, while maintaining current specificity. The resulting models, all based on the presence of periventricular and deep white matter lesions, performed roughly in agreement with the B/T criteria, but were unable to provide higher diagnostic accuracy based...

  19. A New Hybrid MGBPSO-GSA Variant for Improving Function Optimization Solution in Search Space

    Directory of Open Access Journals (Sweden)

    Narinder Singh

    2017-03-01

    Full Text Available In this article, a newly hybrid nature-inspired approach (MGBPSO-GSA is developed with a combination of Mean Gbest Particle Swarm Optimization (MGBPSO and Gravitational Search Algorithm (GSA. The basic inspiration is to integrate the ability of exploitation in MGBPSO with the ability of exploration in GSA to synthesize the strength of both approaches. As a result, the presented approach has the automatic balance capability between local and global searching abilities. The performance of the hybrid approach is tested on a variety of classical functions, ie, unimodal, multimodal, and fixed-dimension multimodal functions. Furthermore, Iris data set, Heart data set, and economic dispatch problems are used to compare the hybrid approach with several metaheuristics. Experimental statistical solutions prove empirically that the new hybrid approach outperforms significantly a number of metaheuristics in terms of solution stability, solution quality, capability of local and global optimum, and convergence speed.

  20. Data Transformation Functions for Expanded Search Spaces in Geographic Sample Supervised Segment Generation

    OpenAIRE

    Christoff Fourie; Elisabeth Schoepfer

    2014-01-01

    Sample supervised image analysis, in particular sample supervised segment generation, shows promise as a methodological avenue applicable within Geographic Object-Based Image Analysis (GEOBIA). Segmentation is acknowledged as a constituent component within typically expansive image analysis processes. A general extension to the basic formulation of an empirical discrepancy measure directed segmentation algorithm parameter tuning approach is proposed. An expanded search landscape is defined, c...

  1. Combined constraints on the SUSY parameter space from $\\Delta$r and Higgs boson search

    CERN Document Server

    Chankowski, P H

    1994-01-01

    Abstract: Combining the constraints coming from the ~M_W ~measurements and the unsuccesful search for the Higgs boson at LEP we determine in the framework of MSSM the allowed mass regions for the lighter scalar partner of the top quark. For a heavy top quark particularily strong bounds are obtained for low values of ~\\tan\\beta\\equiv v_2/v_1 ~and light bottom squark.

  2. A naïve ontology for concepts of time and space for searching and learning

    Directory of Open Access Journals (Sweden)

    M. Miwa

    2007-01-01

    Full Text Available Introduction. In this paper, we propose a new approach for developing a naïve ontology as the basis for optimal information access interfaces for multimedia digital documents intended for novice users. Method. We try to elicit the knowledge structure of domain novices and patterns of its modification in their searching and learning processes by eye-tracker and showing eye-movements in the post-search interviews. Analysis. Recorded interview data were fully transcribed and coded using Atlas.ti and analysed following a bottom-up strategy of the constant-comparative technique. Results. We developed a taxonomy of knowledge modification which includes (1 adding, (2 correcting, (3 limiting, (4 relating, (5 specifying and (6 transforming. Conclusion. The taxonomy may be expanded and elaborated as the project progress and findings are expected to be incorporated into the design of the naïve ontology. The study results provided theoretical implications on knowledge building, methodological implications on data collection using eye-tracker and showing eye-movements in the post-search interviews and useful information on the design of information access interface for novices users.

  3. Optimization of Dynamically Generated SQL Queries for Tiny-Huge, Huge-Tiny Problem

    Directory of Open Access Journals (Sweden)

    Arjun K Sirohi

    2013-03-01

    Full Text Available In most new commercial business software applications like Customer Relationship Management, the datais stored in the database layer which is usually a Relational Database Management System (RDBMS likeOracle, DB2 UDB or SQL Server. To access data from these databases, Structured Query Language (SQLqueries are used that are generated dynamically at run time based on defined business models and businessrules. One such business rule is visibility- the capability of the application to restrict data access based onthe role and responsibility of the user logged in to the application. This is generally achieved by appendingsecurity predicates in the form of sub-queries to the main query based on the roles and responsibility of theuser. In some cases, the outer query may be more restrictive while in other cases, the security predicatesmay be more restrictive. This often results in a dilemma for the cost-based optimizer (CBO of the backenddatabase whether to drive from the outer query or drive from the security predicate sub-queries. Thisdilemma is sometimes called the “Tiny-Huge, Huge-Tiny” problem and results in serious performancedegradation by way of increased response times on the application User Interface (UI. This paperprovides a case study of a new approach to vastly reduce this CBO dilemma by a combination of denormalizedcolumns and re-writing of the security predicates’ sub-queries at run-time, thereby levelling theouter and security sub-queries. This approach results in more stable execution plans in the database andmuch better performance of such SQLs, effectively leading to higher performance and scalability of theapplication.

  4. The First Deep Space Cubesat Broadband IR Spectrometer, Lunarcubes, and the Search for Lunar Volatiles

    Science.gov (United States)

    Clark, P. E.; Malphrus, Ben; Reuter, Dennis; MacDowall, Robert; Folta, David; Hurford, Terry; Brambora, Cliff; Farrell, William

    2017-01-01

    BIRCHES is the compact broadband IR spectrometer of the Lunar Ice Cube mission. Lunar Ice Cube is one of 13 6U cubesats that will be deployed by EM1 in cislunar space, qualifying as lunarcubes. The LunarCube paradigm is a proposed approach for extending the affordable CubeSat standard to support access to deep space via cis-lunar/lunar missions. Because the lunar environment contains analogs of most solar system environments, the Moon is an ideal target for both testing critical deep space capabilities and understanding solar system formation and processes. Effectively, as developments are occurring in parallel, 13 prototype deep space cubesats are being flown for EM1. One useful outcome of this 'experiment' will be to determine to what extent it is possible to develop a lunarcube 'bus' with standardized interfaces to all subsystems using reasonable protocols for a variety of payloads. The lunar ice cube mission was developed as the test case in a GSFC R&D study to determine whether the cubesat paradigm could be applied to deep space, science requirements driven missions, and BIRCHES was its payload. JPL's Lunar Flashlight, and Arizona State University's LunaH-Map, both also EM1 lunar orbiters, will also be deployed from EM1 and provide complimentary observations to be used in understanding volatile dynamics in the same time frame.

  5. EEG/ERP adaptive noise canceller design with controlled search space (CSS) approach in cuckoo and other optimization algorithms.

    Science.gov (United States)

    Ahirwal, M K; Kumar, Anil; Singh, G K

    2013-01-01

    This paper explores the migration of adaptive filtering with swarm intelligence/evolutionary techniques employed in the field of electroencephalogram/event-related potential noise cancellation or extraction. A new approach is proposed in the form of controlled search space to stabilize the randomness of swarm intelligence techniques especially for the EEG signal. Swarm-based algorithms such as Particles Swarm Optimization, Artificial Bee Colony, and Cuckoo Optimization Algorithm with their variants are implemented to design optimized adaptive noise canceler. The proposed controlled search space technique is tested on each of the swarm intelligence techniques and is found to be more accurate and powerful. Adaptive noise canceler with traditional algorithms such as least-mean-square, normalized least-mean-square, and recursive least-mean-square algorithms are also implemented to compare the results. ERP signals such as simulated visual evoked potential, real visual evoked potential, and real sensorimotor evoked potential are used, due to their physiological importance in various EEG studies. Average computational time and shape measures of evolutionary techniques are observed 8.21E-01 sec and 1.73E-01, respectively. Though, traditional algorithms take negligible time consumption, but are unable to offer good shape preservation of ERP, noticed as average computational time and shape measure difference, 1.41E-02 sec and 2.60E+00, respectively.

  6. Eliminating Redundant Search Space on Backtracking for Forward Chaining Theorem Proving

    Institute of Scientific and Technical Information of China (English)

    Lifeng He; Yuyan Chao; Hidenori Itoh

    2003-01-01

    This paper introduces some improvements on the intelligent backtracking strategyfor forward chaining theorem proving. How to decide a minimal useful consequent atom set for a refutation derived at a node in a proof tree is discussed. In most cases, an unnecessary non-Horn clause used for forward chaining will be split only once. The increase of the search spaceby invoking unnecessary forward chaining clauses will be nearly linear, not exponential anymore.In this paper, the principle of the proposed method and its correctness are introduced. Moreover,some examples are provided to show that the proposed approach is powerful for forward chaining theorem proving.

  7. Critical point search from an extended parameter space of lattice QCD at finite temperature and density

    CERN Document Server

    Ejiri, Shinji; Yamada, Norikazu

    2016-01-01

    Aiming to understand the phase structure of lattice QCD at nonzero temperature and density, we study the phase transitions of QCD in an extended parameter space, where the number of flavor and quark masses are considered as parameters. Performing simulations of 2 flavor QCD and using the reweighting method, we investigate (2+Nf) flavor QCD at finite density, where two light flavors and Nf massive flavors exist. Calculating probability distribution functions, we determine the critical surface terminating first order phase transitions in the parameter space of the light quark mass, the heavy quark mass and the chemical potential. Through the study of the many flavor system, we discuss the phase structure of QCD at finite density.

  8. Searching For The Living Space Archetype%探寻居住空间的原型

    Institute of Scientific and Technical Information of China (English)

    陈翔; 郑嘉禧

    2016-01-01

    Basing on the archetype theory by Carl Jung and further comprehension of architecture archetype from the existing researches, the article traces back to primitive period of human nature when the concept of living space archetype had been shaped, influencing peoples’ ideas of living, hence introducing the idea and its importance of living space archetype.%以荣格的原型理论及已有学者对建筑原型分析理解为基础,探寻居住空间原型如何在原始时期开始形成并影响居住理念的发展,提出居住空间原型概念的存在及其重要性。

  9. RadioAstron and millimetron space observatories: Multiverse models and the search for life

    Science.gov (United States)

    Kardashev, N. S.

    2017-04-01

    The transition from the radio to the millimeter and submillimeter ranges is very promising for studies of galactic nuclei, as well as detailed studies of processes related to supermassive black holes, wormholes, and possible manifestations of multi-element Universe (Multiverse) models. This is shown by observations with the largest interferometer available—RadioAstron observatory—that will be used for the scientific program forMillimetron observatory. Observations have also shown the promise of this range for studies of the formation and evolution of planetary systems and searches for manifestations of intelligent life. This is caused by the requirements to use a large amount of condensedmatter and energy in large-scale technological activities. This range can also be used efficiently in the organisation of optimal channels for the transmission of information.

  10. Marine Microbial Mats and the Search for Evidence of Life in Deep Time and Space

    Science.gov (United States)

    Des Marais, David J.

    2011-01-01

    Cyanobacterial mats in extensive seawater evaporation ponds at Guerrero Negro, Baja California, Mexico, have been excellent subjects for microbial ecology research. The studies reviewed here have documented the steep and rapidly changing environmental gradients experienced by mat microorganisms and the very high rates of biogeochemical processes that they maintained. Recent genetic studies have revealed an enormous diversity of bacteria as well as the spatial distribution of Bacteria, Archaea and Eukarya. These findings, together with emerging insights into the intimate interactions between these diverse populations, have contributed substantially to our understanding of the origins, environmental impacts, and biosignatures of photosynthetic microbial mats. The biosignatures (preservable cells, sedimentary fabrics, organic compounds, minerals, stable isotope patterns, etc.) potentially can serve as indicators of past life on early Earth. They also can inform our search for evidence of any life on Mars. Mars exploration has revealed evidence of evaporite deposits and thermal spring deposits; similar deposits on Earth once hosted ancient microbial mat ecosystems.

  11. Searching for Bio-Precursors and Complex Organic Molecules in Space using the GBT

    Science.gov (United States)

    Cordiner, M.; Charnley, S.; Kisiel, Z.

    2012-01-01

    Using the latest microwave receiver technology, large organic molecules with abundances as low as approx. 10(exp -11) times that of molecular hydrogen are detectable in cold interstellar clouds via their rotational emission line spectra. We report new observations to search for complex molecules, including molecules of possible pre-biotic importance, using the newly-commissioned Kband focal plane array (KFPA) of the NRAO Robert C. Byrd Green Bank Telescope. Spectra are presented of the dense molecular cloud TMC-1, showing strict upper limits on the level of emission from nitrogen-bearing rings pyrimidine, quinoline and iso-quinoline, carbon-chain oxides C60, C70, HC60 and HC70, and the carbon-chain anion C4H-. The typical RMS brightness temperature noise levels we achieved are approx. 1 mK at around 20 GHz.

  12. A HUGE SILENT INTRACRANIA L HYDATID CYST IN AN ADULT MALE: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Sonal

    2015-04-01

    Full Text Available Hydatid disease of the brain is a rare parasitic infestation caused by larval stage of Echinococcus granulosus. It has an insidious onset with a slow rate of growth resulting in late diagnosis. Its occurence is rare in India, being endemic in Mediterranean countries and Middle East. We report a case of a huge, slow - growing, silent intracranial left parieto - temporo - occipital hydatid cyst in an 18 year old male presenting as a large cystic space occupying lesion.

  13. Scarless surgery for a huge liver cyst: A case report.

    Science.gov (United States)

    Kashiwagi, Hiroyuki; Kawachi, Jun; Isogai, Naoko; Ishii, Masanori; Miyake, Katsunori; Shimoyama, Rai; Fukai, Ryota; Ogino, Hidemitsu

    2017-09-01

    Symptomatic or complicated liver cysts sometimes require surgical intervention and laparoscopic fenestration is the definitive treatment for these cysts. We performed minimally invasive surgery, hybrid natural orifice transluminal endoscopic surgery (NOTES) without scarring, for a huge liver cyst. An 82-year-old female presented with a month-long history of right upper abdominal pain. We diagnosed her condition as a huge liver cyst by morphological studies. She denied any history of abdominal trauma. Her serum CEA and CA19-9 were normal and a serum echinococcus serologic test was negative. Laparoscopic fenestration, using a hybrid NOTES procedure via a transvaginal approach, was performed for a huge liver cyst because we anticipated difficulty with an umbilical approach, such as single incision laparoscopic surgery (SILS). Her post-operative course was uneventful and she was discharged from our hospital three days after surgery. Pain killers were not required during and after hospitalization. No recurrence of the liver cyst or bulging was detected by clinical examination two years later. A recent trend of laparoscopic procedure has been towards minimizing the number of incisions to achieve less invasiveness. This hybrid NOTES, with a small incision for abdominal access, along with vaginal access, enabled painless operation for a huge liver cyst. We report a huge liver cyst treated by hybrid NOTES. This approach is safe, less invasive, and may be the first choice for a huge liver cyst. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  14. Search for Space-Time Correlations from the Planck Scale with the Fermilab Holometer

    CERN Document Server

    Chou, Aaron S; Hogan, Craig; Kamai, Brittany; Kwon, Ohkyung; Lanza, Robert; McCuller, Lee; Meyer, Stephan S; Richardson, Jonathan; Stoughton, Chris; Tomlin, Raymond; Waldman, Samuel; Weiss, Rainer

    2015-01-01

    Measurements are reported of high frequency cross-spectra of signals from the Fermilab Holometer, a pair of co-located 39 m, high power Michelson interferometers. The instrument obtains differential position sensitivity to cross-correlated signals far exceeding any previous measurement in a broad frequency band extending to the 3.8 MHz inverse light crossing time of the apparatus. A model of universal exotic spatial shear correlations that matches the Planck scale holographic information bound of space-time position states is excluded to 4.6{\\sigma} significance.

  15. A search for new MRI criteria for dissemination in space in subjects with a clinically isolated syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Korteweg, T.; Barkhof, F. [VU University Medical Centre, Department of Radiology, De Boelelaan 1118, HV, Amsterdam (Netherlands); Tintore, M.; Montalban, X. [Hospital Vall d' Hebron, Department of Neuroimmunology, Barcelona (Spain); Uitdehaag, B.M.J. [VU University Medical Centre, Department of Clinical Epidemiology and Biostatistics, Amsterdam (Netherlands); VU University Medical Centre, Department of Neurology, Amsterdam (Netherlands); Knol, D.L. [VU University Medical Centre, Department of Clinical Epidemiology and Biostatistics, Amsterdam (Netherlands); Vrenken, H. [VU University Medical Centre, Department of Physics and Medical Technology, Amsterdam (Netherlands); Rovira, A. [Magnetic Resonance Unit, Department of Radiology, Barcelona (Spain); Frederiksen, J. [University of Copenhagen, The MS Clinic, Department of Neurology, Copenhagen (Denmark); Miller, D.H.; Fernando, K. [University College London, MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, London (United Kingdom); Filippi, M.; Agosta, F.; Rocca, M.A. [Scientific Institute and University Ospedale San Raffaele, Neuroimaging Research Unit, Department of Neurology, Milan (Italy); Fazekas, F.; Enzinger, C. [Medical University Graz, Department of Neurology, Graz (Austria); Parry, A. [University of Oxford, Department of Clinical Neurology, Oxford (United Kingdom); Polman, C.H. [VU University Medical Centre, Department of Neurology, Amsterdam (Netherlands)

    2009-09-15

    The International Panel on the Diagnosis of Multiple Sclerosis (MS) incorporated the Barkhof/Tintore (B/T) magnetic resonance criteria into their diagnostic scheme to provide evidence of dissemination in space of central nervous system lesions, a prerequisite for diagnosing MS in patients who present with clinically isolated syndromes (CIS). Although specific for MS, the B/T criteria were criticised for their low sensitivity and relative complexity in clinical use. We used lesion characteristics at onset from 349 CIS patients in logistic regression and recursive partitioning modelling in a search for simpler and more sensitive criteria, while maintaining current specificity. The resulting models, all based on the presence of periventricular and deep white matter lesions, performed roughly in agreement with the B/T criteria, but were unable to provide higher diagnostic accuracy based on information from a single scan. Apparently, findings from contrast-enhanced and follow-up magnetic resonance scans are needed to improve the diagnostic algorithm. (orig.)

  16. A New Approach to Reducing Search Space and Increasing Efficiency in Simulation Optimization Problems via the Fuzzy-DEA-BCC

    Directory of Open Access Journals (Sweden)

    Rafael de Carvalho Miranda

    2014-01-01

    Full Text Available The development of discrete-event simulation software was one of the most successful interfaces in operational research with computation. As a result, research has been focused on the development of new methods and algorithms with the purpose of increasing simulation optimization efficiency and reliability. This study aims to define optimum variation intervals for each decision variable through a proposed approach which combines the data envelopment analysis with the Fuzzy logic (Fuzzy-DEA-BCC, seeking to improve the decision-making units’ distinction in the face of uncertainty. In this study, Taguchi’s orthogonal arrays were used to generate the necessary quantity of DMUs, and the output variables were generated by the simulation. Two study objects were utilized as examples of mono- and multiobjective problems. Results confirmed the reliability and applicability of the proposed method, as it enabled a significant reduction in search space and computational demand when compared to conventional simulation optimization techniques.

  17. Space Shuttle main engine OPAD: The search for a hardware enhanced plume

    Science.gov (United States)

    Powers, W. T.; Cooper, A. E.; Wallace, Tim L.; Buntine, W. L.; Whitaker, K. W.

    1993-01-01

    The process of applying spectroscopy to the Space Shuttle Main Engine (SSME) for plume diagnostics, as it exists today, originated at Marshall Space Flight Center in Huntsville, Alabama, and its implementation was assured largely through the efforts of Sverdrup AEDC, in Tullahoma, Tennessee. This team continues to lead and guide efforts in the plume diagnostics arena. The process, Optical Plume Anomaly Detection (OPAD), formed the basis for various activities in the development of ground-based systems as well as the development of in-flight plume spectroscopy. OPAD currently provides and will continue to provide valuable information relative to future systems definitions, instrumentation development, code validation, and data diagnostic processing. OPAD is based on the detection of anomalous atomic and molecular species in the SSME plume using two complete, stand-alone optical spectrometers. To-date OPAD has acquired data on 44 test firings of the SSME at the Technology Test Bed (TTB) at MSFC. The purpose of this paper will be to provide an introduction to the OPAD system by discussing the process of obtaining data as well as the methods of examining and interpreting the data. It will encompass such issues as selection of instrumentation correlation of data to nominal engine operation, investigation of SSME component erosion via OPAD spectral data, necessity and benefits of plume seeding, application of artificial intelligence (AI) techniques to data analysis, and the present status of efforts to quantify specie erosion utilizing standard plume and chemistry codes as well as radiative models currently under development.

  18. Search of wormholes in different dimensional non-commutative inspired space-times with Lorentzian distribution

    Energy Technology Data Exchange (ETDEWEB)

    Bhar, Piyali; Rahaman, Farook [Jadavpur University, Department of Mathematics, Kolkata, West Bengal (India)

    2014-12-01

    In this paper we ask whether the wormhole solutions exist in different dimensional noncommutativity-inspired spacetimes. It is well known that the noncommutativity of the space is an outcome of string theory and it replaced the usual point-like object by a smeared object. Here we have chosen the Lorentzian distribution as the density function in the noncommutativity-inspired spacetime. We have observed that the wormhole solutions exist only in four and five dimensions; however, in higher than five dimensions no wormhole exists. For five dimensional spacetime, we get a wormhole for a restricted region. In the usual four dimensional spacetime, we get a stable wormhole which is asymptotically flat. (orig.)

  19. A search for free quarks in the micro gravity environment of the International Space Station

    Science.gov (United States)

    Hudspeth, Paul; Klingler, Robert

    2000-01-01

    Authors propose using the zero-gravity environment of the International Space Station to gather evidence for or against quark particles existing as free radicals in nature. Their proposed method is based on a micro gravity version of 1923 Nobel Prize winner Robert Millikan's oil drop method of determining the fundamental charge on a single electron. Although Millikan's original experiments were carried out in 1909, and showed that all electrical charge exists as whole integer multiples of the fundamental electron unit, Millikan observed and recorded in lab notebooks, the existence of a tiny oil droplet which had a +1/3 partial charge, which he dismissed as an error. Not until the 1960's did quark theory and Particle Accelerators show that protons and neutrons were actually composed of smaller particles called ``quarks'' which indeed bear unique fractional charges. Authors propose observing one millimeter or larger grounded metal spheres suspended in micro gravity between oppositely charged metal plates for telltale motion behavior caused by the fractional charge unique to the quark particle. The ability afforded by micro gravity to use test objects of much greater mass than that of oil droplets equates to being able to perform 100 million Millikan tests in a single run -more by far than the sum total of all the tests ever performed on earth. The significant breakthroughs in terms of deep space propulsion and energy production, hinging on the question of free quark existence, are noted. Preliminary results of basic experimental apparatus construction and testing aboard NASA KC-135 zero-gravity flights are reported, along with recommendations for future experiments. Authors note ideal nature of the experiment in terms of possible student interaction with astronauts and real-time exhibition of testing via the Internet. .

  20. Antimatter and Dark Matter Search in Space: BESS-Polar Results

    Science.gov (United States)

    Mitchell, John W.; Yamamoto, Akira

    2009-01-01

    The apex of the Balloon-borne Experiment with a Superconducting Spectrometer program was reached with the Antarctic flight of BESS-Polar II, during the 2007-2008 Austral Summer, that obtained 24.5 days of data on over 4.7 billion cosmic-ray events. The US-Japan BESS Collaboration uses elementary particle measurements to study the early Universe and provides fundamental data on the spectra of light cosmic-ray elements and isotopes. BESS measures the energy spectra of cosmic-ray antiprotons to investigate signatures of possible exotic sources, such as dark-matter candidates, and searches for heavier anti-nuclei that might reach Earth from antimatter domains formed during symmetry breaking processes in the early Universe. Since 1993, BESS has carried out eleven high-latitude balloon flights, two of long duration, that together have defined the study of antiprotons below about 4 GeV, provided standard references for light element and isotope spectra, and set the most sensitive limits on the existence of anti-deuterons and anti-helium, The BESS-Polar II flight took place at Solar Minimum, when the sensitivity of the low-energy antiproton measurements to a primary source is greatest. The rich BESS-Polar II dataset more than doubles the combined data from all earlier BESS flights and has 10-20 times the statistics of BESS data from the previous Solar Minimum. Here, we summarize the scientific results of BESS program, focusing on the results obtained using data from the long-duration flights of BESS-Polar I (2004) and BESS-Polar II.

  1. A Hubble Space Telescope Search for a Sub-Earth-Sized Exoplanet in the GJ 436 System

    CERN Document Server

    Stevenson, Kevin B; Fabrycky, Daniel; Kreidberg, Laura

    2014-01-01

    The detection of small planets orbiting nearby stars is an important step towards the identification of Earth twins. In previous work using the Spitzer Space Telescope, we found evidence to support at least one sub-Earth-sized exoplanet orbiting the nearby mid-M dwarf star GJ 436. As a follow up, here we used the Hubble Space Telescope to investigate the existence of one of these candidate planets, UCF-1.01, by searching for two transit signals as it passed in front of its host star. Interpretation of the data hinges critically on correctly modeling and removing the WFC3 instrument systematics from the light curves. Building on previous HST work, we demonstrate that WFC3 analyses need to explore the use of a quadratic function to fit a visit-long time-dependent systematic. This is important for establishing absolute transit and eclipse depths in the white light curves of all transiting systems. The work presented here exemplifies this point by putatively detecting the primary transit of UCF-1.01 with the use ...

  2. Firms navigating through innovation spaces: a conceptualization of how firms search and perceive technological, market and productive opportunities globally.

    Science.gov (United States)

    McKelvey, Maureen

    2016-01-01

    The main contribution of this paper is a theory-based conceptual framework of innovation spaces, and how firms must navigate through them to innovate. The concept of innovation systems - at the regional, sectoral and national levels - have been highly influential. Previous literature developing the concept of innovation systems has stressed the importance of institutions, networks and knowledge bases at the regional, sectoral and national levels. This paper primarily draws upon an evolutionary and Schumpeterian economics perspective, in the following three senses. The conceptualization of 'innnovation spaces' focuses upon how and why firm search for innovations is influenced the opportunities within certain geographical contexts. This means that the firm create opportunities and can span different context, but they are influence by the context in term of the access, flow and co-evolution of ideas, resources, technology, people and knowledge, which help stimulate business innovation in terms of products, process and services. The paper concludes with an agenda for future research and especially the need to focus on globalization as a process of intensifying linkages across the globe.

  3. Search for Cosmic-Ray Antiparticles with Balloon-borne and Space-borne Experiments

    CERN Document Server

    von Doetinchem, Ph

    2009-01-01

    This thesis discusses two different approaches for the measurement of cosmic-ray antiparticles in the GeV to TeV energy range. The first part of this thesis discusses the prospects of antiparticle flux measurements with the proposed PEBS detector. The project allots long duration balloon flights at one of Earth's poles at an altitude of 40 km. GEANT4 simulations were carried out which determine the atmospheric background and attenuation especially for antiparticles. The second part covers the AMS-02 experiment which will be installed in 2010 on the International Space Station at an altitude of about 400 km for about three years to measure cosmic rays without the influence of Earth's atmosphere. The present work focuses on the anticoincidence counter system (ACC). The ACC is needed to reduce the trigger rate during periods of high fluxes and to reject external particles crossing the tracker from the side or particles resulting from interactions within the detector which would otherwise disturb the clean charge...

  4. A search for FK Com candidates using Kepler Space Telescope observations: Analogs of HD 199178

    Science.gov (United States)

    Puzin, V. B.; Savanov, I. S.; Dmitrienko, E. S.

    2017-08-01

    Analysis of collected photometric observations obtained with the Kepler Space Telescope were used to select and study 33 objects with parameters corresponding to those of the FK Com starHD199178; these can be considered candidate stars of this type. In this final study, the four objects with the best light curves, which show the properties of their regular rotational modulation most clearly, were selected for detailed studies. The photometric analysis is based on all data currently available in the Kepler archive (covering almost four years). The rotational periods and estimated parameters of the objects' differential rotation are determined, and the longitudes of the dominant active regions on the surfaces found. For all four stars, the spot coverage is approximately 1% of the visible stellar surface area. The rotational periods and data on the stars'masses and radii fromtheMAST catalog are used to determine the rotation velocities projected onto the line of sight, which ranged from 12 to 21 km/s. Further studies will enable definite conclusions about how these stars are related to FK Com stars. If they are ultimately classified as FK Com stars, this will considerably increase the number of this rare type of star and the also number of rapidly rotating, single, late-type giants.

  5. Safety and efficacy of partial hepatectomy for huge (≥10 cm) hepatocellular carcinoma: A systematic review

    Science.gov (United States)

    Zhou, Yan-Ming; Li, Bin; Xu, Dong-Hui; Yang, Jia-Mei

    2011-01-01

    Summary Huge (≥10 cm) hepatocellular carcinoma (HCC) is not uncommon at clinical presentation, and the surgical outcomes of such tumors are poor. This systematic review aimed to assess the safety and efficacy of partial hepatectomy for huge HCC. We performed a search on Medline and PubMed databases for all relevant studies published prior to December 2009. After exclusions, 21 studies remained for appraisal and data extraction. All studies were classified as level-4 evidence. The median overall perioperative morbidity and mortality rates were 29.2% (range: 13.6–72%) and 3.5% (range: 0–18.2%), respectively. The overall median survival since the partial hepatectomy was 20.7 months (range: 10.1–32 months), with median 1-, 3- and 5-year survival of 60.7% (range: 41–72.2%), 34% (range: 0–60.3%) and 28.6% (range: 0–54%), respectively. The median disease-free survival since the partial hepatectomy was 11.3 months (range: 5.5–32months), with median 1-, 3- and 5-year disease-free survival rates of 48.7% (range: 32–65.4%), 27.5% (range: 14.1–49%) and 20.7% (range: 9.5–43%), respectively. Partial hepatectomy can be performed safely and is associated with long-term survival in a subset of patients with huge HCC, but the evidence of benefit is currently weak. PMID:21358616

  6. AsteroidFinder - The Space-Borne Telescope to Search for NEO Asteroids

    Science.gov (United States)

    Hartl, M.; Mosebach, H.; Schubert, J.; Michaelis, H.; Mottola, S.; Kührt, E.; Schindler, K.

    2010-10-01

    This paper presents the mission profile as well as the optical configuration of the space-borne AsteroidFinder telescope. Its main objective is to retrieve asteroids with orbits interior to the earth's orbit. The instrument requires high sensitivity to detect asteroids with a limiting magnitude of equal or larger than 18.5mag (V-Band) and astrometric accuracy of 1arcsec (1σ). This requires a telescope aperture greater than 400cm2, high image stability, detector with high quantum efficiency (peak > 90%) and very low noise, which is only limited by zodiacal background. The telescope will observe the sky between 30° and 60° in solar elongation. The telescope optics is based on a Cook type TMA. An effective 2°×2° field of view (FOV) is achieved by a fast F/3.4 telescope with near diffraction-limited performance. The absence of centre obscuration or spiders in combination with an accessible intermediate field plane and exit pupil allow for efficient stray light mitigation. Design drivers for the telescope are the required point spread function (PSF) values, an extremely efficient stray light suppression (due to the magnitude requirement mentioned above), the detector performance, and the overall optical and mechanical stability for all orientations of the satellite. To accommodate the passive thermal stabilization scheme and the necessary structural stability, the materials selection for the telescope main structure and the mirrors are of vital importance. A focal plane with four EMCCD detectors is envisaged. The EMCCD technology features shorter integration times, which is in favor regarding the pointing performance of the satellite. The launch of the mission is foreseen for the year 2013 with a subsequent mission lifetime of at least 1 year.

  7. A case of a huge gastroepiploic arterial aneurysm.

    Science.gov (United States)

    Ikeda, Hirokuni; Takeo, Masahiko; Mikami, Ryuuichi; Yamamoto, Mistuo

    2015-08-05

    An 85-year-old man complaining of vague abdominal discomfort was admitted to our hospital. A pulsatile 8 × 7-cm mass in the right upper abdomen was noticed on clinical examination. Computed tomography of the abdomen showed a huge arterial aneurysm in the right gastroepiploic artery, and the left gastroepiploic artery was meandering and expanding. An image diagnosis of gastroepiploic arterial aneurysm (GEAA) was made. Because of the huge size of the aneurysm and the predicted high risk of perforation, surgical intervention was planned. The aneurysm was identified in the greater curve and was found to adhere firmly to the transverse colon. Partial resection of the stomach, aneurysmectomy and partial resection of the transverse colon were performed. Clinically, splanchnic arterial aneurysms are rare. Among them, GEAA is especially rare. We report a rare case of a huge GEAA that was treated successfully by surgery. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2015.

  8. Successful Vaginal Delivery despite a Huge Ovarian Mucinous Cystadenoma Complicating Pregnancy: A Case Report

    Directory of Open Access Journals (Sweden)

    Dipak Mandi

    2013-12-01

    Full Text Available A 22-year-old patient with 9 months of amenorrhea and a huge abdominal swelling was admitted to our institution with an ultrasonography report of a multiloculated cystic space-occupying lesion, almost taking up the whole abdomen (probably of ovarian origin, along with a single live intrauterine fetus. She delivered vaginally a boy baby within 4 hours of admission without any maternal complication, but the baby had features of intrauterine growth restriction along with low birth weight. On the 8th postpartum day, the multiloculated cystic mass, which arose from the right ovary and weighed about 11 kg, was removed via laparotomy. A mucinous cystadenoma with no malignant cells in peritoneal washing was detected in histopathology examination. This report describes a rare case of a successful vaginal delivery despite a huge cystadenoma of the right ovary complicating the pregnancy.

  9. Air conditioning management of huge rooms; Gestion climatique des locaux de grande dimension

    Energy Technology Data Exchange (ETDEWEB)

    Guitton, P. [Electricite de France (EDF), 78 - Chatou (France); Izard, J.L. [Ecole d`Architecture de Marseille-Luminy, 13 - Marseille-Luminy (France); Wurtz, E. [La Rochelle Universite, 17 - La Rochelle, LEPTAB (France)] [and others

    1999-09-01

    This conference was organized by the section `air-conditioning engineering` of the French society of thermal engineers (SFT). This document comprises the abridged versions of the communications and deals with: air-conditioning using displacement: experience feedback on tertiary applications and development of a dimensioning tool, thermal response of linear atria, application of the zonal method to the description of the temperature field and flows pattern inside an auditorium, theoretical and experimental study of air renewal inside industrial rooms, management of huge rooms, design of new optimized buildings and use of the TAS software, can TRNSYS and Comis codes be used for huge spaces?, experimental study of the thermal-aeraulic conditions generated by a displacement air-conditioning device. (J.S.)

  10. Anaesthetic management in a case of huge plunging ranula.

    Science.gov (United States)

    Sheet, Jagabandhu; Mandal, Anamitra; Sengupta, Swapnadeep; Jana, Debaleena; Mukherji, Sudakshina; Swaika, Sarbari

    2014-01-01

    Plunging ranula is a rare form of mucous retention cyst arising from submandibular and sublingual salivary glands, which may occasionally become huge occupying the whole of the floor of the mouth and extending into the neck, thus, restricting the neck movement as well as disfiguring the normal airway anatomy. Without fiberoptic assistance, blind or retrograde nasal intubation remains valuable choices in this type of situation. Here, we present a case of successful management of airway by blind nasal intubation in a patient posted for excision of a huge plunging ranula.

  11. Huge Gastric Teratoma in an 8-Year Old Boy.

    Science.gov (United States)

    Sisodiya, Rajpal S; Ratan, Simmi K; Man, Parveen K

    2016-01-01

    Gastric teratoma is very rare tumor and usually presents in early infancy. An 8-year-old boy presented with a huge mass in abdomen extending from epigastrium to the pelvis. Ultrasound and CT scan of abdomen revealed a huge mass with solid and cystic components and internal calcifications. The preoperative diagnosis was a teratoma but not specifically gastric one. At operation, it was found to be gastric teratoma. The mass was excised completely with part of the stomach wall. The histopathology confirmed it to be mature gastric teratoma. The rarity of the teratoma with delayed presentation prompted us to report the case.

  12. Anaesthetic challenges in a patient presenting with huge neck teratoma

    Directory of Open Access Journals (Sweden)

    Gaurav Jain

    2013-01-01

    Full Text Available Paediatric airway management is a great challenge even for an experienced anaesthesiologist. Difficult airway in huge cervical teratoma further exaggerates the complexity. This case report is intended at describing the intubation difficulties that were confronted during the airway management of a three year old girl presenting with huge neck teratoma and respiratory distress. This patient was successfully intubated with uncuffed endotracheal tubes in second attempt under inhalational anaesthesia with halothane and spontaneous ventilation. This case exemplifies the importance of careful preoperative workup of an anticipated difficult airway in paediatric patients with neck swelling to minimize any perioperative complications.

  13. Huge pelvic mass secondary to wear debris causing ureteral obstruction.

    Science.gov (United States)

    Hananouchi, Takehito; Saito, Masanobu; Nakamura, Nobuo; Yamamoto, Tetsuya; Yonenobu, Kazuo

    2005-10-01

    We report an unusual granulomatous reaction of wear debris that produced a huge pelvic mass causing ureteral obstruction. A 72-year-old woman, who received a cemented total hip arthroplasty 30 years ago, was referred to the department of gynecology for examination of a pelvic mass. A computed tomography scan revealed a huge homogenous mass, measuring approximately 20 x 16 x 12 cm, including extensive osteolysis of the left pelvis around the acetabular component. Intravenous pyelogram revealed complete obstruction of the left ureter resulting in hydronephrosis of the left kidney. Histological examination from the biopsy specimen detected polyethylene wear debris in the mass.

  14. Anaesthetic management in a case of huge plunging ranula

    Science.gov (United States)

    Sheet, Jagabandhu; Mandal, Anamitra; Sengupta, Swapnadeep; Jana, Debaleena; Mukherji, Sudakshina; Swaika, Sarbari

    2014-01-01

    Plunging ranula is a rare form of mucous retention cyst arising from submandibular and sublingual salivary glands, which may occasionally become huge occupying the whole of the floor of the mouth and extending into the neck, thus, restricting the neck movement as well as disfiguring the normal airway anatomy. Without fiberoptic assistance, blind or retrograde nasal intubation remains valuable choices in this type of situation. Here, we present a case of successful management of airway by blind nasal intubation in a patient posted for excision of a huge plunging ranula. PMID:25886120

  15. Searching and Archiving : Exploring Online Search Behaviors of Researchers

    NARCIS (Netherlands)

    Vyas, D.M.; Groot, de S.; Veer, van der G.C.; Dainoff, M.J.

    2007-01-01

    Searching for relevant peer-reviewed material is an integral part of corporate and academic researchers. Researchers collect huge amount of information over the years and sometimes struggle organizing it. Based on a study with 30 academic researchers, we explore, in combination, different searching

  16. Imaging of huge lingual thyroid gland with goitre

    Energy Technology Data Exchange (ETDEWEB)

    Lee, C.C.; Chen, C.Y.; Chen, F.H.; Lee, G.W.; Hsiao, H.S. [Nat. Defense Medical Centre, Taipei (Taiwan, Province of China). Dept. of Diagnostic Radiol.; Zimmermann, R.A. [Department of Radiology, The Children`s Hospital of Philadelphia, 34th St. and Civic Blvd., Philadelphia, PA 19014 (United States)

    1998-05-01

    We present the CT and MRI findings in a 75-year-old woman with a huge pathologically proven lingual thyroid which underwent goitrous degeneration. CT and MRI showed a midline, tongue-based, exophytic mass with areas of necrosis and heterogeneous contrast enhancement, as seen in large goitres in the normal thyroid gland. (orig.) With 1 fig., 7 refs.

  17. Smart Cities as Support and Legacy of Huge Sport Events

    Directory of Open Access Journals (Sweden)

    TAURION, C.

    2012-12-01

    Full Text Available In this paper we discuss the concept of a smart city and the importance of huge Sport events as an incentive to the creation of the infrastructure necessary for the development of cities that provide quality of life for all its citizens using information technology.

  18. The big, large and huge case of state-building

    DEFF Research Database (Denmark)

    Harste, Gorm

      Using communication theory as point of departure, it is not evident how to study macro phenomena. Michel Foucault limited his studies to a non-Grand Theory when studying discursive events. At the same time, Charles Tilly wrote about Big Structures, Large Processes, Huge Comparisons when trying...

  19. [Experience of surgical treatment of huge mediastinal tumors].

    Science.gov (United States)

    Li, Yuanbo; Zhang, Yi; Xu, Qingsheng; Su, Lei; Zhi, Xiuyi; Wang, Ruotian; Qian, Kun; Hu, Mu; Liu, Lei

    2014-09-23

    The diagnosis and surgical treatment of 36 huge mediastinal tumors were summarized in order to evaluate the effect and safety of the operation. Thirty-six huge mediastinal tumor patients treated in our department from June 2006 to June 2013 were retrospective analyzed, of whom clinical manifestations, diagnosis, surgical treatment and prognosis were carefully collected. Twenty-three cases were men and 13 were women. The average age was 39.2 years old. The pathology turned out to be benign in 23 cases and malignant in 13 cases. Complete resection was achieved in 34 cases while palliative resection in 2 cases with no perioperative death. Six cases had developed postoperative complications but all recovered after active treatment. Patients who had been diagnosed with benign tumors were all alive after follow-up periods of 6 months to 7 years. Nine malignat tumor patients developed recurrence or metastasis, including seven deaths. Surgery played a vital role in the diagnosis and treatment of huge mediastinal tumors. Preoperative diagnosis, accurate surgical approach and careful operation were the key to successful treatment. Benign huge mediastinal tumors had excellent prognosis with surgery.

  20. A Huge Ovarian Dermoid Cyst: Successful Laparoscopic Total Excision.

    Science.gov (United States)

    Uyanikoglu, Hacer; Dusak, Abdurrahim

    2017-08-01

    Giant ovarian cysts, ≥15 cm in diameter, are quite rare in women of reproductive age. Here, we present a case of ovarian cyst with unusual presentation treated by laparoscopic surgery. On histology, mass was found to be mature cystic teratoma. The diagnostic and management challenges posed by this huge ovarian cyst were discussed in the light of the literature.

  1. Huge mediastinal liposarcoma resected by clamshell thoracotomy: a case report.

    Science.gov (United States)

    Toda, Michihito; Izumi, Nobuhiro; Tsukioka, Takuma; Komatsu, Hiroaki; Okada, Satoshi; Hara, Kantaro; Ito, Ryuichi; Shibata, Toshihiko; Nishiyama, Noritoshi

    2017-12-01

    Liposarcoma is the single most common soft tissue sarcoma. Because mediastinal liposarcomas often grow rapidly and frequently recur locally despite adjuvant chemotherapy and radiotherapy, they require complete excision. Therefore, the feasibility of achieving complete surgical excision must be carefully considered. We here report a case of a huge mediastinal liposarcoma resected via clamshell thoracotomy. A 64-year-old man presented with dyspnea on effort. Cardiomegaly had been diagnosed 6 years previously, but had been left untreated. A computed tomography scan showed a huge (36 cm diameter) anterior mediastinal tumor expanding into the pleural cavities bilaterally. The tumor comprised mostly fatty tissue but contained two solid areas. Echo-guided needle biopsies were performed and a diagnosis of an atypical lipomatous tumor was established by pathological examination of the biopsy samples. Surgical resection was performed via a clamshell incision, enabling en bloc resection of this huge tumor. Although there was no invasion of surrounding organs, the left brachiocephalic vein was resected because it was circumferentially surrounded by tumor and could not be preserved. The tumor weighed 3500 g. Pathologic examination of the resected tumor resulted in a diagnosis of a biphasic tumor comprising dedifferentiated liposarcoma and non-adipocytic sarcoma with necrotic areas. The patient remains free of recurrent tumor 20 months postoperatively. Clamshell incision provides an excellent surgical field and can be performed safely in patients with huge mediastinal liposarcomas.

  2. A Hubble space telescope search for a sub-Earth-sized exoplanet in the GJ 436 system

    Energy Technology Data Exchange (ETDEWEB)

    Stevenson, Kevin B. [NASA Sagan Fellow. (United States); Bean, Jacob L.; Fabrycky, Daniel; Kreidberg, Laura, E-mail: kbs@uchicago.edu [Department of Astronomy and Astrophysics, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States)

    2014-11-20

    The detection of small planets orbiting nearby stars is an important step toward the identification of Earth twins. In previous work using the Spitzer Space Telescope, we found evidence to support at least one sub-Earth-sized exoplanet orbiting the nearby mid-M dwarf star GJ 436. As a follow up, here we used the Hubble Space Telescope (HST) to investigate the existence of one of these candidate planets, UCF-1.01, by searching for two transit signals as it passed in front of its host star. Interpretation of the data hinges critically on correctly modeling and removing the Wide Field Camera 3 (WFC3) instrument systematics from the light curves. Building on previous HST work, we demonstrate that WFC3 analyses need to explore the use of a quadratic function to fit a visit-long time-dependent systematic. This is important for establishing absolute transit and eclipse depths in the white light curves of all transiting systems. The work presented here exemplifies this point by putatively detecting the primary transit of UCF-1.01 with the use of a linear trend. However, using a quadratic trend, we achieve a better fit to the white light curves and a reduced transit depth that is inconsistent with previous Spitzer measurements. Furthermore, quadratic trends with or without a transit model component produce comparable fits to the available data. Using extant WFC3 transit light curves for GJ 436b, we further validate the quadratic model component by achieving photon-limited model fit residuals and consistent transit depths over multiple epochs. We conclude that, when we fit for a quadratic trend, our new data contradict the prediction of a sub-Earth-sized planet orbiting GJ 436 with the size, period, and ephemeris posited from the Spitzer data by a margin of 3.1σ.

  3. Identification of Predictive Cis-Regulatory Elements Using a Discriminative Objective Function and a Dynamic Search Space.

    Science.gov (United States)

    Karnik, Rahul; Beer, Michael A

    2015-01-01

    The generation of genomic binding or accessibility data from massively parallel sequencing technologies such as ChIP-seq and DNase-seq continues to accelerate. Yet state-of-the-art computational approaches for the identification of DNA binding motifs often yield motifs of weak predictive power. Here we present a novel computational algorithm called MotifSpec, designed to find predictive motifs, in contrast to over-represented sequence elements. The key distinguishing feature of this algorithm is that it uses a dynamic search space and a learned threshold to find discriminative motifs in combination with the modeling of motifs using a full PWM (position weight matrix) rather than k-mer words or regular expressions. We demonstrate that our approach finds motifs corresponding to known binding specificities in several mammalian ChIP-seq datasets, and that our PWMs classify the ChIP-seq signals with accuracy comparable to, or marginally better than motifs from the best existing algorithms. In other datasets, our algorithm identifies novel motifs where other methods fail. Finally, we apply this algorithm to detect motifs from expression datasets in C. elegans using a dynamic expression similarity metric rather than fixed expression clusters, and find novel predictive motifs.

  4. The millimeter wave spectrum of methyl cyanate: a laboratory study and astronomical search in space ⋆,⋆⋆

    Science.gov (United States)

    Kolesniková, L.; Alonso, J. L.; Bermúdez, C.; Alonso, E. R.; Tercero, B.; Cernicharo, J.; Guillemin, J.-C.

    2016-01-01

    Aims The recent discovery of methyl isocyanate (CH3NCO) in Sgr B2(N) and Orion KL makes methyl cyanate (CH3OCN) a potential molecule in the interstellar medium. The aim of this work is to fulfill the first requirement for its unequivocal identification in space, i.e. the availability of transition frequencies with high accuracy. Methods The room-temperature rotational spectrum of methyl cyanate was recorded in the millimeter wave domain from 130 to 350 GHz. All rotational transitions revealed A-E splitting owing to methyl internal rotation and were globally analyzed using the ERHAM program. Results The data set for the ground torsional state of methyl cyanate exceeds 700 transitions within J″ = 10 – 35 and Ka″=0−13 and newly derived spectroscopic constants reproduce the spectrum close to the experimental uncertainty. Spectral features of methyl cyanate were then searched for in Orion KL, Sgr B2(N), B1-b, and TMC-1 molecular clouds. Upper limits to the column density of methyl cyanate are provided. PMID:27721514

  5. Identification of Predictive Cis-Regulatory Elements Using a Discriminative Objective Function and a Dynamic Search Space.

    Directory of Open Access Journals (Sweden)

    Rahul Karnik

    Full Text Available The generation of genomic binding or accessibility data from massively parallel sequencing technologies such as ChIP-seq and DNase-seq continues to accelerate. Yet state-of-the-art computational approaches for the identification of DNA binding motifs often yield motifs of weak predictive power. Here we present a novel computational algorithm called MotifSpec, designed to find predictive motifs, in contrast to over-represented sequence elements. The key distinguishing feature of this algorithm is that it uses a dynamic search space and a learned threshold to find discriminative motifs in combination with the modeling of motifs using a full PWM (position weight matrix rather than k-mer words or regular expressions. We demonstrate that our approach finds motifs corresponding to known binding specificities in several mammalian ChIP-seq datasets, and that our PWMs classify the ChIP-seq signals with accuracy comparable to, or marginally better than motifs from the best existing algorithms. In other datasets, our algorithm identifies novel motifs where other methods fail. Finally, we apply this algorithm to detect motifs from expression datasets in C. elegans using a dynamic expression similarity metric rather than fixed expression clusters, and find novel predictive motifs.

  6. Huge focal nodular hyperplasia presenting in a 6-year-old child: A case presentation.

    Science.gov (United States)

    Zhuang, Lin; Ni, Chuangye; Din, Wenbing; Zhang, Feng; Zhuang, Yi; Sun, Yawei; Xi, Dong

    2016-01-01

    Focal nodular hyperplasia (FNH) is a benign lesion of the liver which is usually found in healthy adults, however, FNH is rare in children, and comprises only 2% of all pediatric liver tumors. Herein, we report the case of a 6-year-old child (male) with a huge FNH which size is more than 10cm. This could be the biggest FNH among all children's FNH cases ever reported. A 6-year-old boy was found a hepatic space-occupying lesion two years ago. As the time went by, the lesion became bigger gradually. The last CT examination showed the size of the tumor to be 10.5×9.9cm in the right hepatic lobe. This child underwent surgical resection of the tumor which was confirmed as FNH (11×8×7cm) by pathology. FNH is a benign lesion of the liver, and it is characterized by hepatocyte hyperplasia and a central stellate scar. It is uncommon for FNH to be diagnosed in children. Such huge FNH (about 11cm) is extremely rare. Surgical operation may be the effective method to cure huge FNH. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  7. Search Analytics for Your Site

    CERN Document Server

    Rosenfeld, Louis

    2011-01-01

    Any organization that has a searchable web site or intranet is sitting on top of hugely valuable and usually under-exploited data: logs that capture what users are searching for, how often each query was searched, and how many results each query retrieved. Search queries are gold: they are real data that show us exactly what users are searching for in their own words. This book shows you how to use search analytics to carry on a conversation with your customers: listen to and understand their needs, and improve your content, navigation and search performance to meet those needs.

  8. Huge uterine-cervical diverticulum mimicking as a cyst

    Directory of Open Access Journals (Sweden)

    S Chufal

    2012-01-01

    Full Text Available Here we report an incidental huge uterine-cervical diverticulum from a total abdominal hysterectomy specimen in a perimenopausal woman who presented with acute abdominal pain. The diverticulum was mimicking with various cysts present in the lateral side of the female genital tract. Histopathological examination confirmed this to be a cervical diverticulum with communication to uterine cavity through two different openings. They can attain huge size if left ignored for long duration and present a diagnostic challenge to clinicians, radiologists, as well as pathologists because of its extreme rarity. Therefore, diverticula should also be included as a differential diagnosis. Its histopathological confirmation also highlights that diverticula can present as an acute abdomen, requiring early diagnosis with appropriate timely intervention. Immunohistochemistry CD 10 has also been used to differentiate it from a mesonephric cyst.

  9. Huge uterine-cervical diverticulum mimicking as a cyst.

    Science.gov (United States)

    Chufal, S; Thapliyal, Naveen; Gupta, Manoj; Pangtey, Nirmal

    2012-01-01

    Here we report an incidental huge uterine-cervical diverticulum from a total abdominal hysterectomy specimen in a perimenopausal woman who presented with acute abdominal pain. The diverticulum was mimicking with various cysts present in the lateral side of the female genital tract. Histopathological examination confirmed this to be a cervical diverticulum with communication to uterine cavity through two different openings. They can attain huge size if left ignored for long duration and present a diagnostic challenge to clinicians, radiologists, as well as pathologists because of its extreme rarity. Therefore, diverticula should also be included as a differential diagnosis. Its histopathological confirmation also highlights that diverticula can present as an acute abdomen, requiring early diagnosis with appropriate timely intervention. Immunohistochemistry CD 10 has also been used to differentiate it from a mesonephric cyst.

  10. A case of huge primary liposarcoma in the liver

    Institute of Scientific and Technical Information of China (English)

    Liang-Mou Kuo; Hong-Shiue Chou; Kun-Ming Chan; Ming-Chin Yu; Wei-Chen Lee

    2006-01-01

    Primary liver liposarcoma is a rare disease. Because of its rarity, the knowledge of the clinical course, management, and prognosis of primary liver liposarcoma are all limited for clinicians. A 61-year-old female patient who suffered from a huge primary liposarcoma in the central portion of the liver had the clinical presentations of fever, nausea, vomiting, jaundice, and body weight loss.The huge tumor was resected successfully. However,the tumor recurred repeatedly and she had repeated hepatectomies to remove the tumor. Thetumor became aggravating after repeated surgeries. Eventually, the patient had cervical spinal metastasis of liposarcoma and she survived for 26 months after liver liposarcoma was diagnosed. Although the tumor may become aggravating after repeated surgeries, repeated hepatectomies are still the best policy to achieve a long-term survival for the patients.

  11. Black Hole Firewalls Require Huge Energy of Measurement

    CERN Document Server

    Hotta, Masahiro; Funo, Ken

    2013-01-01

    The unitary moving mirror model is one of the best quantum systems for checking the reasoning of the firewall paradox in quantum black holes. The reasoning of Almheiri et al. inevitably raises a firewall paradox in the model. We resolve this paradox from the viewpoint of the energy cost of quantum measurements. No firewall with a deadly, huge energy flux appears, as long as the energy for the measurement is much smaller than the ultraviolet cutoff scale.

  12. Severe microphthalmos with cyst and unusually huge dermolipoma.

    Science.gov (United States)

    Li, Weidong; Zhang, Ping; Chen, Qiwen; Ye, Xuelian; Li, Jianqun; Yan, Jianhua

    2015-03-01

    The purpose of this study was to report an unusual case of severe microphthalmos, together with an orbital cyst and huge ocular surface dermolipoma. This is a clinical report relating clinical features as well as imaging and histopathologic findings, along with surgical management of the patient. A 5-month-old Chinese male infant was referred, with 2 large masses in the left eye that were present since birth. Ocular examination results revealed a complete absence of any eye structures in the left orbit. In its place were 2 large masses between the left upper and lower palpebral fissure. One was a 3 × 3 × 2.5-cm spherical red tumor with a smooth surface. The other was a large solid spherical tumor, 4 × 4 × 5 cm, covered with normal skin located in the temporal region and attached to the red mass by a pedicle. Orbital magnetic resonance imaging examination findings confirmed that no eye structures were present in the left orbit. However, a cystic lesion was found in the left orbit, with a low signal on T1-weighted imaging and high signal on T2-weighted imaging, and another huge spherical heterogeneous mass was located "outside" the left orbit. Anterior orbitotomy by conjunctival incision was performed under general anesthesia. A spherical cystic mass of 1.5 × 1.5 × 1.6 cm, a small eye of 0.7 × 0.7 × 0.6 cm, and a huge dermolipoma were removed completely. Pathologic examination results confirmed the diagnosis of severe microphthalmos, together with orbital dermoid cyst and dermolipoma. This rare case demonstrates that severe microphthalmos with a cyst may be completely covered by conjunctiva and associated with an unusually huge dermolipoma.

  13. Huge plastic bezoar: a rare cause of gastrointestinal obstruction.

    Science.gov (United States)

    Yaka, Mbarek; Ehirchiou, Abdelkader; Alkandry, Tariq Tajdin Sifeddine; Sair, Khalid

    2015-01-01

    Bezoars are rare causes of gastrointestinal obstruction. Basically, they are of four types: trichobezoars, phytobezoars, pharmacobezoars, and lactobezoars. Some rare types of bezoars are also known. In this article a unique case of plastic bezoars is presented. We describe a girl aged 14 years who ingested large amounts of plastic material used for knitting chairs and charpoys. The conglomerate of plastic threads, entrapped food material and other debris, formed a huge mass occupying the whole stomach and extended into small bowel.

  14. A Huge Cystic Retroperitoneal Lymphangioma Presenting with Back Pain

    Science.gov (United States)

    Kubachev, Kubach; Abdullaev, Elbrus; Babyshin, Valentin; Neronov, Dmitriy; Abdullaev, Abakar

    2016-01-01

    Retroperitoneal lymphangioma is a rare location and type of benign abdominal tumors. The clinical presentation of this rare disease is nonspecific, ranging from abdominal distention to sepsis. Here we present a 73-year-old female patient with 3-month history of back pain. USG and CT revealed a huge cystic mass which was surgically excised and appeared to be lymphangioma on histopathology. PMID:27843456

  15. Huge Left Atrium Accompanied by Normally Functioning Prosthetic Valve.

    Science.gov (United States)

    Sabzi, Feridoun

    2015-01-01

    Giant left atria are defined as those measuring larger than 8 cm and are typically found in patients who have rheumatic mitral valve disease with severe regurgitation. Enlargement of the left atrium may create compression of the surrounding structures such as the esophagus, pulmonary veins, respiratory tract, lung, inferior vena cava, recurrent laryngeal nerve, and thoracic vertebrae and lead to dysphagia, respiratory dysfunction, peripheral edema, hoarse voice, or back pain. However, a huge left atrium is usually associated with rheumatic mitral valve disease but is very rare in a normally functioning prosthetic mitral valve, as was the case in our patient. A 46-year-old woman with a past medical history of mitral valve replacement and chronic atrial fibrillation was admitted to our hospital with a chief complaint of cough and shortness of breath, worsened in the last month. Physical examination showed elevated jugular venous pressure, respiratory distress, cardiac cachexia, heart failure, hepatomegaly, and severe edema in the legs. Chest radiography revealed an inconceivably huge cardiac sell-out. Transthoracic echocardiography demonstrated a huge left atrium, associated with thrombosis, and normal function of the prosthetic mitral valve. Cardiac surgery with left atrial exploration for the extraction of the huge thrombosis and De Vega annuloplasty for tricuspid regurgitation were carried out. The postoperative course was eventful due to right ventricular failure and low cardiac output syndrome; and after two days, the patient expired with multiple organ failure. Thorough literature review showed that our case was the largest left atrium (20 × 22 cm) reported thus far in adults with a normal prosthetic mitral valve function.

  16. Huge Left Atrium Accompanied by Normally Function- ing Prosthetic Valve

    Directory of Open Access Journals (Sweden)

    Feridoun Sabzi

    2015-10-01

    Full Text Available Giant left atria are defined as those measuring larger than 8 cm and are typically found in patients who have rheumatic mitral valve disease with severe regurgitation. Enlargement of the left atrium may create compression of the surrounding structures such as the esophagus, pulmonary veins, respiratory tract, lung, inferior vena cava, recurrent laryngeal nerve, and thoracic vertebrae and lead to dysphagia, respiratory dysfunction, peripheral edema, hoarse voice, or back pain. However, a huge left atrium is usually associated with rheumatic mitral valve disease but is very rare in a normally functioning prosthetic mitral valve, as was the case in our patient. A 46-year-old woman with a past medical history of mitral valve replacement and chronic atrial fibrillation was admitted to our hospital with a chief complaint of cough and shortness of breath, worsened in the last month. Physical examination showed elevated jugular venous pressure, respiratory distress, cardiac cachexia, heart failure, hepatomegaly, and severe edema in the legs. Chest radiography revealed an inconceivably huge cardiac sell-out. Transthoracic echocardiography demonstrated a huge left atrium, associated with thrombosis, and normal function of the prosthetic mitral valve. Cardiac surgery with left atrial exploration for the extraction of the huge thrombosis and De Vega annuloplasty for tricuspid regurgitation were carried out. The postoperative course was eventful due to right ventricular failure and low cardiac output syndrome; and after two days, the patient expired with multiple organ failure. Thorough literature review showed that our case was the largest left atrium (20 × 22 cm reported thus far in adults with a normal prosthetic mitral valve function.

  17. Huge Nevus Lipomatosus Cutaneous Superficialis on Back: An Unusual Presentation.

    Science.gov (United States)

    Das, Dipti; Das, Anupam; Bandyopadhyay, Debabrata; Kumar, Dhiraj

    2015-01-01

    Nevus lipomatosus cutaneous superficialis (NLCS) is a benign dermatosis, histologically characterized by the presence of mature ectopic adipocytes in the dermis. We hereby report a case of a 10-year-old boy who presented with multiple huge swellings on the scapular regions and lower back. The lesions were surmounted by small papules, along with peau-d orange appearance at places. Histology showed features consistent with NLCS. The case is being reported for the unusual clinical presentation.

  18. Huge nevus lipomatosus cutaneous superficialis on back: An unusual presentation

    Directory of Open Access Journals (Sweden)

    Dipti Das

    2015-01-01

    Full Text Available Nevus lipomatosus cutaneous superficialis (NLCS is a benign dermatosis, histologically characterized by the presence of mature ectopic adipocytes in the dermis. We hereby report a case of a 10-year-old boy who presented with multiple huge swellings on the scapular regions and lower back. The lesions were surmounted by small papules, along with peau-d orange appearance at places. Histology showed features consistent with NLCS. The case is being reported for the unusual clinical presentation.

  19. Huge Intravascular Tumor Extending to the Heart: Leiomyomatosis

    Directory of Open Access Journals (Sweden)

    Suat Doganci

    2015-01-01

    Full Text Available Intravenous leiomyomatosis (IVL is a rare neoplasm characterized by histologically benign-looking smooth muscle cell tumor mass, which is growing within the intrauterine and extrauterine venous system. In this report we aimed to present an unusual case of IVL, which is originating from iliac vein and extended throughout to right cardiac chambers. A 49-year-old female patient, who was treated with warfarin sodium due to right iliac vein thrombosis, was admitted to our department with intermittent dyspnea, palpitation, and dizziness. Physical examination was almost normal except bilateral pretibial edema. On magnetic resonance venography, there was an intravenous mass, which is originated from right internal iliac vein and extended into the inferior vena cava. Transthoracic echocardiography and transesophageal echocardiography revealed a huge mass extending from the inferior vena cava through the right atrium, with obvious venous occlusion. Thoracic, abdominal, and pelvic MR showed an intravascular mass, which is concordant with leiomyomatosis. Surgery was performed through median sternotomy. A huge mass with 25-cm length and 186-gr weight was excised through right atrial oblique incision, on beating heart with cardiopulmonary bypass. Histopathologic assessment was compatible with IVL. Exact strategy for the surgical treatment of IVL is still controversial. We used one-stage approach, with complete resection of a huge IVL extending from right atrium to right iliac vein. In such cases, high recurrence rate is a significant problem; therefore it should be kept in mind.

  20. Multimodality treatment with radiotherapy for huge hepatocellular carcinoma.

    Science.gov (United States)

    Han, Hee Ji; Kim, Mi Sun; Cha, Jihye; Choi, Jin Sub; Han, Kwang Hyub; Seong, Jinsil

    2014-01-01

    For huge hepatocellular carcinoma (HCC), therapeutic decisions have varied from local therapy to systemic therapy, with radiotherapy (RT) playing only a palliative role. In this study, we investigated whether multimodality treatment involving RT could be effective in huge HCC. This study was performed in 116 patients with HCC >10 cm. The number of patients in stage II, III and IV was 12, 54 and 50, respectively. RT was given as a combined modality in most patients. The median dose was 45 Gy, with 1.8 Gy per fraction. The median overall survival (OS) and progression-free survival (PFS) were 14.8 and 6.5 months, respectively. The median infield PFS was not reached. Infield failure, outfield intrahepatic and extrahepatic failure were observed in 8.6, 18.1, and 12.1% of patients, respectively. For OS and PFS, number of tumors, initial alpha-fetoprotein (AFP) level, treatment response, percent AFP decrement, and hepatic resection were significant prognostic factors. Tumor characteristics and treatment response were significantly different between long-term survivors and the other patients. Although huge HCC presents an aggressive clinical course, multimodality approaches involving RT can offer an opportunity for prolonged survival. © 2014 S. Karger AG, Basel.

  1. Huge Intravascular Tumor Extending to the Heart: Leiomyomatosis.

    Science.gov (United States)

    Doganci, Suat; Kaya, Erkan; Kadan, Murat; Karabacak, Kubilay; Erol, Gökhan; Demirkilic, Ufuk

    2015-01-01

    Intravenous leiomyomatosis (IVL) is a rare neoplasm characterized by histologically benign-looking smooth muscle cell tumor mass, which is growing within the intrauterine and extrauterine venous system. In this report we aimed to present an unusual case of IVL, which is originating from iliac vein and extended throughout to right cardiac chambers. A 49-year-old female patient, who was treated with warfarin sodium due to right iliac vein thrombosis, was admitted to our department with intermittent dyspnea, palpitation, and dizziness. Physical examination was almost normal except bilateral pretibial edema. On magnetic resonance venography, there was an intravenous mass, which is originated from right internal iliac vein and extended into the inferior vena cava. Transthoracic echocardiography and transesophageal echocardiography revealed a huge mass extending from the inferior vena cava through the right atrium, with obvious venous occlusion. Thoracic, abdominal, and pelvic MR showed an intravascular mass, which is concordant with leiomyomatosis. Surgery was performed through median sternotomy. A huge mass with 25-cm length and 186-gr weight was excised through right atrial oblique incision, on beating heart with cardiopulmonary bypass. Histopathologic assessment was compatible with IVL. Exact strategy for the surgical treatment of IVL is still controversial. We used one-stage approach, with complete resection of a huge IVL extending from right atrium to right iliac vein. In such cases, high recurrence rate is a significant problem; therefore it should be kept in mind.

  2. Search for charginos and neutralinos in $e^+ e^-$ collisions at centre-of-mass energies near 183 GeV and constraints on the MSSM parameter space

    CERN Document Server

    Barate, R; Ghez, P; Goy, C; Jézéquel, S; Lees, J P; Martin, F; Merle, E; Minard, M N; Nief, J Y; Pietrzyk, B; Alemany, R; Casado, M P; Chmeissani, M; Crespo, J M; Delfino, M C; Fernández, E; Fernández-Bosman, M; Garrido, L; Graugès-Pous, E; Juste, A; Martínez, M; Merino, G; Miquel, R; Mir, L M; Morawitz, P; Pacheco, A; Park, I C; Pascual, A; Riu, I; Sánchez, F; Colaleo, A; Creanza, D; De Palma, M; Gelao, G; Iaselli, Giuseppe; Maggi, G; Maggi, M; Nuzzo, S; Ranieri, A; Raso, G; Ruggieri, F; Selvaggi, G; Silvestris, L; Tempesta, P; Tricomi, A; Zito, G; Huang, X; Lin, J; Ouyang, Q; Wang, T; Xie, Y; Xu, R; Xue, S; Zhang, J; Zhang, L; Zhao, W; Abbaneo, D; Becker, U; Boix, G; Cattaneo, M; Ciulli, V; Dissertori, G; Drevermann, H; Forty, Roger W; Frank, M; Gianotti, F; Halley, A W; Hansen, J B; Harvey, J; Janot, P; Jost, B; Lehraus, Ivan; Leroy, O; Loomis, C; Maley, P; Mato, P; Minten, Adolf G; Moutoussi, A; Ranjard, F; Rolandi, Luigi; Rousseau, D; Schlatter, W D; Schmitt, M; Schneider, O; Tejessy, W; Teubert, F; Tomalin, I R; Tournefier, E; Vreeswijk, M; Wright, A E; Ajaltouni, Ziad J; Badaud, F; Chazelle, G; Deschamps, O; Dessagne, S; Falvard, A; Ferdi, C; Gay, P; Guicheney, C; Henrard, P; Jousset, J; Michel, B; Monteil, S; Montret, J C; Pallin, D; Perret, P; Podlyski, F; Hansen, J D; Hansen, J R; Hansen, P H; Nilsson, B S; Rensch, B; Wäänänen, A; Daskalakis, G; Kyriakis, A; Markou, C; Simopoulou, Errietta; Vayaki, Anna; Blondel, A; Brient, J C; Machefert, F P; Rougé, A; Swynghedauw, M; Tanaka, R; Valassi, Andrea; Videau, H L; Focardi, E; Parrini, G; Zachariadou, K; Cavanaugh, R J; Corden, M; Georgiopoulos, C H; Antonelli, A; Bencivenni, G; Bologna, G; Bossi, F; Campana, P; Capon, G; Cerutti, F; Chiarella, V; Laurelli, P; Mannocchi, G; Murtas, F; Murtas, G P; Passalacqua, L; Pepé-Altarelli, M; Chalmers, M; Curtis, L; Lynch, J G; Negus, P; O'Shea, V; Räven, B; Raine, C; Smith, D; Teixeira-Dias, P; Thompson, A S; Ward, J J; Buchmüller, O L; Dhamotharan, S; Geweniger, C; Hanke, P; Hansper, G; Hepp, V; Kluge, E E; Putzer, A; Sommer, J; Tittel, K; Werner, S; Wunsch, M; Beuselinck, R; Binnie, David M; Cameron, W; Dornan, Peter J; Girone, M; Goodsir, S M; Marinelli, N; Martin, E B; Nash, J; Nowell, J; Sedgbeer, J K; Spagnolo, P; Thomson, E; Williams, M D; Ghete, V M; Girtler, P; Kneringer, E; Kuhn, D; Rudolph, G; Betteridge, A P; Bowdery, C K; Buck, P G; Colrain, P; Crawford, G; Ellis, G; Finch, A J; Foster, F; Hughes, G; Jones, R W L; Robertson, N A; Williams, M; Van Gemmeren, P; Giehl, I; Hölldorfer, F; Hoffmann, C; Jakobs, K; Kleinknecht, K; Kröcker, M; Nürnberger, H A; Quast, G; Renk, B; Rohne, E; Sander, H G; Schmeling, S; Wachsmuth, H W; Zeitnitz, C; Ziegler, T; Aubert, Jean-Jacques; Benchouk, C; Bonissent, A; Carr, J; Coyle, P; Ealet, A; Fouchez, D; Motsch, F; Payre, P; Talby, M; Thulasidas, M; Tilquin, A; Aleppo, M; Antonelli, M; Ragusa, F; Berlich, R; Büscher, V; Dietl, H; Ganis, G; Hüttmann, K; Lütjens, G; Mannert, C; Männer, W; Moser, H G; Schael, S; Settles, Ronald; Seywerd, H C J; Stenzel, H; Wiedenmann, W; Wolf, G; Boucrot, J; Callot, O; Chen, S; Davier, M; Duflot, L; Grivaz, J F; Heusse, P; Jacholkowska, A; Kado, M; Kim, D W; Lefrançois, J; Serin, L; Veillet, J J; Videau, I; De Vivie de Régie, J B; Zerwas, D; Azzurri, P; Bagliesi, G; Bettarini, S; Boccali, T; Bozzi, C; Calderini, G; Dell'Orso, R; Fantechi, R; Ferrante, I; Giassi, A; Gregorio, A; Ligabue, F; Lusiani, A; Marrocchesi, P S; Messineo, A; Palla, Fabrizio; Rizzo, G; Sanguinetti, G; Sciabà, A; Sguazzoni, G; Tenchini, Roberto; Vannini, C; Venturi, A; Verdini, P G; Blair, G A; Chambers, J T; Coles, J; Cowan, G D; Green, M G; Hutchcroft, D E; Jones, L T; Medcalf, T; Strong, J A; Von Wimmersperg-Töller, J H; Botterill, David R; Clifft, R W; Edgecock, T R; Norton, P R; Thompson, J C; Bloch-Devaux, B; Colas, P; Fabbro, B; Faïf, G; Lançon, E; Lemaire, M C; Locci, E; Pérez, P; Przysiezniak, H; Rander, J; Renardy, J F; Rosowsky, A; Trabelsi, A; Tuchming, B; Vallage, B; Black, S N; Dann, J H; Kim, H Y; Konstantinidis, N P; Litke, A M; McNeil, M A; Taylor, G; Booth, C N; Cartwright, S L; Combley, F; Hodgson, P N; Kelly, M S; Lehto, M H; Thompson, L F; Affholderbach, K; Böhrer, A; Brandt, S; Foss, J; Grupen, Claus; Misiejuk, A; Prange, G; Sieler, U; Smolik, L; Stephan, F; Giannini, G; Gobbo, B; Pütz, J; Rothberg, J E; Wasserbaech, S R; Williams, R W; Armstrong, S R; Charles, E; Elmer, P; Ferguson, D P S; Gao, Y; González, S; Greening, T C; Hayes, O J; Hu, H; Jin, S; Mamier, G; McNamara, P A; Nachtman, J M; Nielsen, J; Orejudos, W; Pan, Y B; Saadi, Y; Scott, I J; Vogt, M; Walsh, J; Wu Sau Lan; Wu, X; Zobernig, G

    1999-01-01

    Searches for charginos and neutralinos are performed with the data collected by the ALEPH detector at LEP at centre-of-mass energies near 183 GeV. In these searches, it is assumed that R-parity is conserved and that the lightest neutralino is the LSP. No evidence of a signal is observed in the 57 pb-1 accumulated, which excludes chargino and associated neutralino production up to the kinematic limit over large regions of the MSSM parameter space. Under the assumptions of common gaugino and common sfermion masses at the unification scale, the interplay between the chargino, neutralino and slepton exclusions allows a lower limit of 27 GeV/c2 to be set on the mass of the lightest neutralino. Tighter constraints on the MSSM parameter space are obtained using in addition exclusions in the Higgs sector. Finally, the results are interpreted within the framework of minimal supergravity.

  3. Recent advances in intelligent image search and video retrieval

    CERN Document Server

    2017-01-01

    This book initially reviews the major feature representation and extraction methods and effective learning and recognition approaches, which have broad applications in the context of intelligent image search and video retrieval. It subsequently presents novel methods, such as improved soft assignment coding, Inheritable Color Space (InCS) and the Generalized InCS framework, the sparse kernel manifold learner method, the efficient Support Vector Machine (eSVM), and the Scale-Invariant Feature Transform (SIFT) features in multiple color spaces. Lastly, the book presents clothing analysis for subject identification and retrieval, and performance evaluation methods of video analytics for traffic monitoring. Digital images and videos are proliferating at an amazing speed in the fields of science, engineering and technology, media and entertainment. With the huge accumulation of such data, keyword searches and manual annotation schemes may no longer be able to meet the practical demand for retrieving relevant conte...

  4. A HUBBLE SPACE TELESCOPE/COSMIC ORIGINS SPECTROGRAPH SEARCH FOR WARM-HOT BARYONS IN THE Mrk 421 SIGHT LINE

    Energy Technology Data Exchange (ETDEWEB)

    Danforth, Charles W.; Stocke, John T.; Keeney, Brian A.; Penton, Steven V.; Shull, J. Michael; Yao Yangsen; Green, James C., E-mail: danforth@colorado.edu [CASA, Department of Astrophysical and Planetary Sciences, University of Colorado, 389-UCB, Boulder, CO 80309 (United States)

    2011-12-10

    Thermally broadened Ly{alpha} absorbers (BLAs) offer an alternate method to using highly ionized metal absorbers (O VI, O VII, etc.) to probe the warm-hot intergalactic medium (WHIM, T = 10{sup 5}-10{sup 7} K). Until now, WHIM surveys via BLAs have been no less ambiguous than those via far-UV and X-ray metal-ion probes. Detecting these weak, broad features requires background sources with a well-characterized far-UV continuum and data of very high quality. However, a recent Hubble Space Telescope/Cosmic Origins Spectrograph (COS) observation of the z = 0.03 blazar Mrk 421 allows us to perform a metal-independent search for WHIM gas with unprecedented precision. The data have high signal-to-noise ratio (S/N Almost-Equal-To 50 per {approx}20 km s{sup -1} resolution element) and the smooth, power-law blazar spectrum allows a fully parametric continuum model. We analyze the Mrk 421 sight line for BLA absorbers, particularly for counterparts to the proposed O VII WHIM systems reported by Nicastro et al. based on Chandra/Low Energy Transmission Grating observations. We derive the Ly{alpha} profiles predicted by the X-ray observations. The S/N of the COS data is high (S/N Almost-Equal-To 25 pixel{sup -1}), but much higher S/N can be obtained by binning the data to widths characteristic of the expected BLA profiles. With this technique, we are sensitive to WHIM gas over a large (N{sub H}, T) parameter range in the Mrk 421 sight line. We rule out the claimed Nicastro et al. O VII detections at their nominal temperatures (T {approx} 1-2 Multiplication-Sign 10{sup 6} K) and metallicities (Z = 0.1 Z{sub Sun }) at {approx}> 2{sigma} level. However, WHIM gas at higher temperatures and/or higher metallicities is consistent with our COS non-detections.

  5. Analyzing huge pathology images with open source software.

    Science.gov (United States)

    Deroulers, Christophe; Ameisen, David; Badoual, Mathilde; Gerin, Chloé; Granier, Alexandre; Lartaud, Marc

    2013-06-06

    Digital pathology images are increasingly used both for diagnosis and research, because slide scanners are nowadays broadly available and because the quantitative study of these images yields new insights in systems biology. However, such virtual slides build up a technical challenge since the images occupy often several gigabytes and cannot be fully opened in a computer's memory. Moreover, there is no standard format. Therefore, most common open source tools such as ImageJ fail at treating them, and the others require expensive hardware while still being prohibitively slow. We have developed several cross-platform open source software tools to overcome these limitations. The NDPITools provide a way to transform microscopy images initially in the loosely supported NDPI format into one or several standard TIFF files, and to create mosaics (division of huge images into small ones, with or without overlap) in various TIFF and JPEG formats. They can be driven through ImageJ plugins. The LargeTIFFTools achieve similar functionality for huge TIFF images which do not fit into RAM. We test the performance of these tools on several digital slides and compare them, when applicable, to standard software. A statistical study of the cells in a tissue sample from an oligodendroglioma was performed on an average laptop computer to demonstrate the efficiency of the tools. Our open source software enables dealing with huge images with standard software on average computers. They are cross-platform, independent of proprietary libraries and very modular, allowing them to be used in other open source projects. They have excellent performance in terms of execution speed and RAM requirements. They open promising perspectives both to the clinician who wants to study a single slide and to the research team or data centre who do image analysis of many slides on a computer cluster. The virtual slide(s) for this article can be found here

  6. A NOVEL APPROACH FOR PATTERN ANALYSIS FROM HUGE DATAWAREHOUSE

    Directory of Open Access Journals (Sweden)

    BABITA

    2014-05-01

    Full Text Available Due to the tremendous growth of data and large databases, efficient extraction of required data has become a challenging task. This paper propose a novel approach for knowledge discovery from huge unlabeled temporal databases by employing a combination of HMM and K-means technique. We propose to recursively divide the entire database into clusters having similar characteristics, this process is repeated until we get the cluster’s where no further diversification is possible. Thereafter, the clusters are labeled for knowledge extraction for various purposes.

  7. A young woman with a huge paratubal cyst

    Directory of Open Access Journals (Sweden)

    Ceren Golbasi

    2016-09-01

    Full Text Available Paratubal cysts are asymptomatic embryological remnants. These cysts are usually diagnosed during adolescence and reproductive age. In general, their sizes are small but can be complicated by rupture, torsion, or hemorrhage. Paratubal cysts are often discovered fortuitously on routine ultrasound examination. We report a 19-year-old female patient who presented with irregular menses and abdominal pain. Ultrasound examination revealed a huge cystic mass at the right adnexial area. The diagnosis was confirmed as paratubal cyst during laporotomy and, hence, cystectomy and right salpingectomy were performed. [Cukurova Med J 2016; 41(3.000: 573-576

  8. Modeling huge sound sources in a room acoustical calculation program

    DEFF Research Database (Denmark)

    Christensen, Claus Lynge

    1999-01-01

    A room acoustical model capable of modeling point sources, line sources, and surface sources is presented. Line and surface sources are modeled using a special ray-tracing algorithm detecting the radiation pattern of the surfaces of the room. Point sources are modeled using a hybrid calculation...... method combining this ray-tracing method with image source modeling. With these three source types it is possible to model huge and complex sound sources in industrial environments. Compared to a calculation with only point sources, the use of extended sound sources is shown to improve the agreement...

  9. A huge renal capsular leiomyoma mimicking retroperitoneal sarcoma

    Directory of Open Access Journals (Sweden)

    Lal Anupam

    2009-01-01

    Full Text Available A huge left renal capsular leiomyoma mimicking retroperitoneal sarcoma presented in a patient as an abdominal mass. Computed tomography displayed a large heterogeneous retro-peritoneal mass in the left side of the abdomen with inferior and medial displacement as well as loss of fat plane with the left kidney. Surgical exploration revealed a capsulated mass that was tightly adherent to the left kidney; therefore, total tumor resection with radical left nephrectomy was performed. Histopathology ultimately confirmed the benign nature of the mass. This is the largest leiomyoma reported in literature to the best of our knowledge.

  10. Huge pyometra in a postmenopausal age: a diagnostic dilemma

    Directory of Open Access Journals (Sweden)

    Pramila Yadav

    2015-10-01

    Full Text Available Pyometra in postmenopausal women is an extremely rare disease that hardly responds to the usual treatment of antibiotics therapy. Our case presented as a postmenopausal woman with a huge pyometra. Pyometra drainage was done with great difficulty after a blind biopsy. Endometrial and cervical biopsy followed by endometrial curettage was done. An intrauterine foley's catheter was kept for seven days and Histopathological report was suggestive of squamous cell carcinoma of cervix. [Int J Reprod Contracept Obstet Gynecol 2015; 4(5.000: 1549-1551

  11. Severe progressive scoliosis due to huge subcutaneous cavernous hemangioma: A case report

    Directory of Open Access Journals (Sweden)

    Toyama Yoshiaki

    2011-03-01

    Full Text Available Abstract Cavernous hemangioma consists mainly of congenital vascular malformations present before birth and gradually increasing in size with skeletal growth. A small number of patients with cavernous hemangioma develop scoliosis, and surgical treatment for the scoliosis in such cases has not been reported to date. Here we report a 12-year-old male patient with severe progressive scoliosis due to a huge subcutaneous cavernous hemangioma, who underwent posterior correction and fusion surgery. Upon referral to our department, radiographs revealed a scoliosis of 85° at T6-L1 and a kyphosis of 58° at T4-T10. CT and MR images revealed a huge hemangioma extending from the subcutaneous region to the paraspinal muscles and the retroperitoneal space and invading the spinal canal. Posterior correction and fusion surgery using pedicle screws between T2 and L3 were performed. Massive hemorrhage from the hemangioma occurred during the surgery, with intraoperative blood loss reaching 2800 ml. The scoliosis was corrected to 59°, and the kyphosis to 45° after surgery. Seven hours after surgery, the patient suffered from hypovolemic shock and disseminated intravascular coagulation due to postoperative hemorrhage from the hemangioma. The patient developed sensory and conduction aphasia caused by cerebral hypoxia during the shock on the day of the surgery. At present, two years after the surgery, although the patient has completely recovered from the aphasia. This case illustrates that, in correction surgery for scoliosis due to huge subcutaneous cavernous hemangioma, intraoperative and postoperative intensive care for hemodynamics should be performed, since massive hemorrhage can occur during the postoperative period as well as the intraoperative period.

  12. Dynamic Grover search: applications in recommendation systems and optimization problems

    Science.gov (United States)

    Chakrabarty, Indranil; Khan, Shahzor; Singh, Vanshdeep

    2017-06-01

    In the recent years, we have seen that Grover search algorithm (Proceedings, 28th annual ACM symposium on the theory of computing, pp. 212-219, 1996) by using quantum parallelism has revolutionized the field of solving huge class of NP problems in comparisons to classical systems. In this work, we explore the idea of extending Grover search algorithm to approximate algorithms. Here we try to analyze the applicability of Grover search to process an unstructured database with a dynamic selection function in contrast to the static selection function used in the original work (Grover in Proceedings, 28th annual ACM symposium on the theory of computing, pp. 212-219, 1996). We show that this alteration facilitates us to extend the application of Grover search to the field of randomized search algorithms. Further, we use the dynamic Grover search algorithm to define the goals for a recommendation system based on which we propose a recommendation algorithm which uses binomial similarity distribution space giving us a quadratic speedup over traditional classical unstructured recommendation systems. Finally, we see how dynamic Grover search can be used to tackle a wide range of optimization problems where we improve complexity over existing optimization algorithms.

  13. Reduction in database search space by utilization of amino acid composition information from electron transfer dissociation and higher-energy collisional dissociation mass spectra.

    Science.gov (United States)

    Hansen, Thomas A; Kryuchkov, Fedor; Kjeldsen, Frank

    2012-08-07

    With high-mass accuracy and consecutively obtained electron transfer dissociation (ETD) and higher-energy collisional dissociation (HCD) tandem mass spectrometry (MS/MS), reliable (≥97%) and sensitive fragment ions have been extracted for identification of specific amino acid residues in peptide sequences. The analytical benefit of these specific amino acid composition (AAC) ions is to restrict the database search space and provide identification of peptides with higher confidence and reduced false negative rates. The 6706 uniquely identified peptide sequences determined with a conservative Mascot score of >30 were used to characterize the AAC ions. The loss of amino acid side chains (small neutral losses, SNLs) from the charge reduced peptide radical cations was studied using ETD. Complementary AAC information from HCD spectra was provided by immonium ions. From the ETD/HCD mass spectra, 5162 and 6720 reliable SNLs and immonium ions were successfully extracted, respectively. Automated application of the AAC information during database searching resulted in an average 3.5-fold higher confidence level of peptide identification. In addition, 4% and 28% more peptides were identified above the significance level in a standard and extended search space, respectively.

  14. Errors in Seismic Hazard Assessment are Creating Huge Human Losses

    Science.gov (United States)

    Bela, J.

    2015-12-01

    The current practice of representing earthquake hazards to the public based upon their perceived likelihood or probability of occurrence is proven now by the global record of actual earthquakes to be not only erroneous and unreliable, but also too deadly! Earthquake occurrence is sporadic and therefore assumptions of earthquake frequency and return-period are both not only misleading, but also categorically false. More than 700,000 people have now lost their lives (2000-2011), wherein 11 of the World's Deadliest Earthquakes have occurred in locations where probability-based seismic hazard assessments had predicted only low seismic low hazard. Unless seismic hazard assessment and the setting of minimum earthquake design safety standards for buildings and bridges are based on a more realistic deterministic recognition of "what can happen" rather than on what mathematical models suggest is "most likely to happen" such future huge human losses can only be expected to continue! The actual earthquake events that did occur were at or near the maximum potential-size event that either already had occurred in the past; or were geologically known to be possible. Haiti's M7 earthquake, 2010 (with > 222,000 fatalities) meant the dead could not even be buried with dignity. Japan's catastrophic Tohoku earthquake, 2011; a M9 Megathrust earthquake, unleashed a tsunami that not only obliterated coastal communities along the northern Japanese coast, but also claimed > 20,000 lives. This tsunami flooded nuclear reactors at Fukushima, causing 4 explosions and 3 reactors to melt down. But while this history of huge human losses due to erroneous and misleading seismic hazard estimates, despite its wrenching pain, cannot be unlived; if faced with courage and a more realistic deterministic estimate of "what is possible", it need not be lived again. An objective testing of the results of global probability based seismic hazard maps against real occurrences has never been done by the

  15. Distributed and parallel approach for handle and perform huge datasets

    Science.gov (United States)

    Konopko, Joanna

    2015-12-01

    Big Data refers to the dynamic, large and disparate volumes of data comes from many different sources (tools, machines, sensors, mobile devices) uncorrelated with each others. It requires new, innovative and scalable technology to collect, host and analytically process the vast amount of data. Proper architecture of the system that perform huge data sets is needed. In this paper, the comparison of distributed and parallel system architecture is presented on the example of MapReduce (MR) Hadoop platform and parallel database platform (DBMS). This paper also analyzes the problem of performing and handling valuable information from petabytes of data. The both paradigms: MapReduce and parallel DBMS are described and compared. The hybrid architecture approach is also proposed and could be used to solve the analyzed problem of storing and processing Big Data.

  16. Anaethetic management of a neonate with huge cystic hygroma.

    Directory of Open Access Journals (Sweden)

    Bindi Palkhiwala

    2013-01-01

    Full Text Available We discuss here the case of a 7 day old neonate with huge cystic hygroma on the left side of the neck invading the major vessels of neck, facial nerve, strap muscles and sternocleidomastoid. Anasethtic implications in this case were maintaining airway patency after induction, difficult intubation, risk perioperative dislodgement of tube and judgement of proper time for extubation. Following gaseous induction and adequate mask ventilation, patient was intubated with muscle relaxant. peroperatively to avoid accidental extubation, we choose to manually hold the ET tube after fixing it. At the end of relatively uneventful surgery, we could extubate the patient in OT. patient was shifted to NICU for observation. Post operatively on 3rd day, facial palsy was observed. Ptient was discharged on 21st day.

  17. Huge Intracanal lumbar Disc Herniation: a Review of Four Cases

    Directory of Open Access Journals (Sweden)

    Farzad Omidi-Kashani

    2016-01-01

    Full Text Available Lumbar disc herniation (LDH is the most common cause of sciatica and only in about 10% of the affected patients, surgical intervention is necessary. The side of the patient (the side of most prominent clinical complaints is usually consistent with the side of imaging (the side with most prominent disc herniation on imaging scans. In this case series, we presented our experience in four cases with huge intracanal LDH that a mismatch between the patient’s side and the imaging’s side was present. In these cases, for deciding to do the operation, the physicians need to rely more on clinical findings, but for deciding the side of discectomy, imaging characteristic (imaging side may be a more important criterion.

  18. A parallel solver for huge dense linear systems

    Science.gov (United States)

    Badia, J. M.; Movilla, J. L.; Climente, J. I.; Castillo, M.; Marqués, M.; Mayo, R.; Quintana-Ortí, E. S.; Planelles, J.

    2011-11-01

    HDSS (Huge Dense Linear System Solver) is a Fortran Application Programming Interface (API) to facilitate the parallel solution of very large dense systems to scientists and engineers. The API makes use of parallelism to yield an efficient solution of the systems on a wide range of parallel platforms, from clusters of processors to massively parallel multiprocessors. It exploits out-of-core strategies to leverage the secondary memory in order to solve huge linear systems O(100.000). The API is based on the parallel linear algebra library PLAPACK, and on its Out-Of-Core (OOC) extension POOCLAPACK. Both PLAPACK and POOCLAPACK use the Message Passing Interface (MPI) as the communication layer and BLAS to perform the local matrix operations. The API provides a friendly interface to the users, hiding almost all the technical aspects related to the parallel execution of the code and the use of the secondary memory to solve the systems. In particular, the API can automatically select the best way to store and solve the systems, depending of the dimension of the system, the number of processes and the main memory of the platform. Experimental results on several parallel platforms report high performance, reaching more than 1 TFLOP with 64 cores to solve a system with more than 200 000 equations and more than 10 000 right-hand side vectors. New version program summaryProgram title: Huge Dense System Solver (HDSS) Catalogue identifier: AEHU_v1_1 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEHU_v1_1.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 87 062 No. of bytes in distributed program, including test data, etc.: 1 069 110 Distribution format: tar.gz Programming language: Fortran90, C Computer: Parallel architectures: multiprocessors, computer clusters Operating system

  19. A huge glandular odontogenic cyst occurring at posterior mandible

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Gi Chung; Han, Won Jeong; Kim, Eun Kyung [Dankook University College of Medicine, Seoul (Korea, Republic of)

    2004-12-15

    The glandular odontogenic cyst is a rare lesion described in 1987. It generally occurs at anterior region of mandible in adults over the age of 40 and has a slight tendency to recur. Histopathologically, a cystic cavity lined by a nonkeratinized, stratified squamous, or cuboidal epithelium varying in thickness is found including a superficial layer with glandular or pseudoglandular structures. A 21-year-old male visited Dankook University Dental Hospital with a chief complaint of swelling of the left posterior mandible. Radiographically, a huge multilocular radiolucent lesion involving impacted 3rd molar at the posterior mandible was observed. Buccolingual cortical expansion with partial perforation of buccal cortical bone was also shown. Histopathologically, this lesion was lined by stratified squamous epithelium with glandular structures in areas of plaque-like thickening. The final diagnosis was made as a glandular odontogenic cyst.

  20. Does China's Huge External Surplus Imply an Undervalued Renminbi?

    Institute of Scientific and Technical Information of China (English)

    Anthony J. Makin

    2007-01-01

    A pegged exchange rate regime has been pivotal to China's export-led development strategy. However, its huge trade surpluses and massive build up of international reserves have been matched by large deficits for major trading partners, creating acute policy concerns abroad, especially in the USA. This paper provides a straightforward conceptual framework for interpreting the effect of China's exchange rate policy on its own trade balance and that of trading partners in the context of discrepant economic growth rates. It shows how pegging the exchange rate when output is outstripping expenditure induces China's trade surpluses and counterpart deficits for its trading partners. An important corollary is that given its strictly regulated capital account, China's persistently large surpluses imply a significantly undervalued renminbi, which should gradually become more flexible.

  1. Improved Scatter Search Using Cuckoo Search

    Directory of Open Access Journals (Sweden)

    Ahmed T.Sadiq Al-Obaidi

    2013-02-01

    Full Text Available The Scatter Search (SS is a deterministic strategy that has been applied successfully to some combinatorial and continuous optimization problems. Cuckoo Search (CS is heuristic search algorithm which is inspired by the reproduction strategy of cuckoos. This paper presents enhanced scatter search algorithm using CS algorithm. The improvement provides Scatter Search with random exploration for search space of problem and more of diversity and intensification for promising solutions. The original and improved Scatter Search has been tested on Traveling Salesman Problem. A computational experiment with benchmark instances is reported. The results demonstrate that the improved Scatter Search algorithms produce better performance than original Scatter Search algorithm. The improvement in the value of average fitness is 23.2% comparing with original SS. The developed algorithm has been compared with other algorithms for the same problem, and the result was competitive with some algorithm and insufficient with another.

  2. SU-E-T-647: Plan Quality in Computerized Non-Coplanar IMRT Beam Angle Optimization is Highly Dependent on the Extent of the Beam direction Search Space.

    Science.gov (United States)

    Voet, P; Rossi, L; Breedveld, S; Aluwini, S; Heijmen, B

    2012-06-01

    To investigate the relationship between plan quality and the extent of the beam direction search space in computerized beam angle selection for generating optimal (non-coplanar) IMRT plans for prostate SBRT with dose distributions simulating HDR brachytherapy. iCycle (1) was used to investigate the relationship between plan quality and the extent of the set of beam directions available for plan generation. For a group of 10 prostate patients, optimal plans were generated for 5 direction search spaces. For coplanar treatments (CP set), 72 orientations were available for selection (separation 5°). The fully non-coplanar set (F-NCP) included the CP directions plus 430 directions spread over the sphere. The CK set contained the directions available at the robotic Cyberknife unit. CK+ and CK++ were extensions of CK to investigate some of its characteristics. Generated plans were in accordance with our clinical SBRT protocol for Cyberknife treatment, delivering 4 fractions of 9.5 Gy. Adequate PTV coverage had the highest priority. Reduction of rectum dose was the highest OAR priority. The mean PTV coverage (V95) of all SBRT plans was 99% ï,± 0.9% (1 SD). F-NCP plans had most favorable OAR dose parameters, while for coplanar plans OAR doses were highest. Compared to coplanar treatment, rectum Dmean/V60 were 25% / 37% and 19% / 21% lower in F-NCP and CK plans. Higher rectum dose for the Cyberknife set compared to F-NCP was not caused by a lack of posterior beams for Cyberknife. For all search spaces, reduction in OAR dose only leveled off with > 20 beams in the plans (for CP, rectum V60 in 25 beam plans was reduced by 64% compared to 11 beams). In the non-coplanar set-ups, there was a preference for beams with a (large) lateral component. Plan quality clearly improved with the extent of the beam direction search space (coplanar worst), and the number of beam directions in the plan (25 clearly better than 11).(1) Breedveld S, Storchi P, Voet P, Heijmen B, Med Phys 2012

  3. A hybrid color space for skin detection using genetic algorithm heuristic search and principal component analysis technique.

    Directory of Open Access Journals (Sweden)

    Mahdi Maktabdar Oghaz

    Full Text Available Color is one of the most prominent features of an image and used in many skin and face detection applications. Color space transformation is widely used by researchers to improve face and skin detection performance. Despite the substantial research efforts in this area, choosing a proper color space in terms of skin and face classification performance which can address issues like illumination variations, various camera characteristics and diversity in skin color tones has remained an open issue. This research proposes a new three-dimensional hybrid color space termed SKN by employing the Genetic Algorithm heuristic and Principal Component Analysis to find the optimal representation of human skin color in over seventeen existing color spaces. Genetic Algorithm heuristic is used to find the optimal color component combination setup in terms of skin detection accuracy while the Principal Component Analysis projects the optimal Genetic Algorithm solution to a less complex dimension. Pixel wise skin detection was used to evaluate the performance of the proposed color space. We have employed four classifiers including Random Forest, Naïve Bayes, Support Vector Machine and Multilayer Perceptron in order to generate the human skin color predictive model. The proposed color space was compared to some existing color spaces and shows superior results in terms of pixel-wise skin detection accuracy. Experimental results show that by using Random Forest classifier, the proposed SKN color space obtained an average F-score and True Positive Rate of 0.953 and False Positive Rate of 0.0482 which outperformed the existing color spaces in terms of pixel wise skin detection accuracy. The results also indicate that among the classifiers used in this study, Random Forest is the most suitable classifier for pixel wise skin detection applications.

  4. A hybrid color space for skin detection using genetic algorithm heuristic search and principal component analysis technique.

    Science.gov (United States)

    Maktabdar Oghaz, Mahdi; Maarof, Mohd Aizaini; Zainal, Anazida; Rohani, Mohd Foad; Yaghoubyan, S Hadi

    2015-01-01

    Color is one of the most prominent features of an image and used in many skin and face detection applications. Color space transformation is widely used by researchers to improve face and skin detection performance. Despite the substantial research efforts in this area, choosing a proper color space in terms of skin and face classification performance which can address issues like illumination variations, various camera characteristics and diversity in skin color tones has remained an open issue. This research proposes a new three-dimensional hybrid color space termed SKN by employing the Genetic Algorithm heuristic and Principal Component Analysis to find the optimal representation of human skin color in over seventeen existing color spaces. Genetic Algorithm heuristic is used to find the optimal color component combination setup in terms of skin detection accuracy while the Principal Component Analysis projects the optimal Genetic Algorithm solution to a less complex dimension. Pixel wise skin detection was used to evaluate the performance of the proposed color space. We have employed four classifiers including Random Forest, Naïve Bayes, Support Vector Machine and Multilayer Perceptron in order to generate the human skin color predictive model. The proposed color space was compared to some existing color spaces and shows superior results in terms of pixel-wise skin detection accuracy. Experimental results show that by using Random Forest classifier, the proposed SKN color space obtained an average F-score and True Positive Rate of 0.953 and False Positive Rate of 0.0482 which outperformed the existing color spaces in terms of pixel wise skin detection accuracy. The results also indicate that among the classifiers used in this study, Random Forest is the most suitable classifier for pixel wise skin detection applications.

  5. Universal Space IP Transparent Proxy Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Communications applications are strategically moving toward Internet Protocol-based architectures and technologies. Despite IP's huge potential, (e.g. cost...

  6. PRS: PERSONNEL RECOMMENDATION SYSTEM FOR HUGE DATA ANALYSIS USING PORTER STEMMER

    Directory of Open Access Journals (Sweden)

    T N Chiranjeevi

    2016-04-01

    Full Text Available Personal recommendation system is one which gives better and preferential recommendation to the users to satisfy their personalized requirements such as practical applications like Webpage Preferences, Sport Videos preferences, Stock selection based on price, TV preferences, Hotel preferences, books, Mobile phones, CDs and various other products now use recommender systems. The existing Pearson Correlation Coefficient (PCC and item-based algorithm using PCC, are called as UPCC and IPCC respectively. These systems are mainly based on only the rating services and does not consider the user personal preferences, they simply just give the result based on the ratings. As the size of data increases it will give the recommendations based on the top rated services and it will miss out most of user preferences. These are main drawbacks in the existing system which will give same results to the users based on some evaluations and rankings or rating service, they will neglect the user preferences and necessities. To address this problem we propose a new approach called, Personnel Recommendation System (PRS for huge data analysis using Porter Stemmer to solve the above challenges. In the proposed system it provides a personalized service recommendation list to the users and recommends the most useful services to the users which will increase the accuracy and efficiency in searching better services. Particularly, a set of suggestions or keywords are provided to indicate user preferences and we used Collaborative Filtering and Porter Stemmer algorithm which gives a suitable recommendations to the users. In real, the broad experiments are conducted on the huge database which is available in real world, and outcome shows that our proposed personal recommender method extensively improves the precision and efficiency of service recommender system over the KASR method. In our approach mainly consider the user preferences so it will not miss out the any of the data

  7. Late Intervention-Related Complication - A Huge Subepicardial Hematoma.

    Science.gov (United States)

    Ko, Po-Yen; Chang, Chih-Ping; Yang, Chen-Chia; Lin, Jen-Jyh

    2013-05-01

    A 75-year-old man had a history of triple vessel coronary artery disease. In August 2009, he had undergone successful percutaneous coronary intervention to the left circumflex coronary artery (LCX) for management of an in-stent restenosis (ISR) lesion. However, in September 2010, he began experiencing recurrent episodes of exertional chest pain. Chest radiography showed the left cardiac border bulging upwards. Transthoracic echocardiography and chest computed tomography revealed a huge oval mass of about 10.4 cm × 7.9 cm × 8.6 cm, which showed calcification and was obliterating the LCX. Subsequent coronary angiography revealed significant instent restenosis, with extravasation of a small amount of contrast material at the stent location, suggesting that the coronary artery had ruptured. We implanted a polytetrafluoroethylene-covered stent to seal the coronary perforation and to release the occlusion. The patient was symptom-free and had an uneventful outcome until the 1-year follow up. Coronary artery perforation; Covered stent; Hematoma.

  8. A huge posteromedial mediastinal cyst complicated with vertebral dislodgment

    Directory of Open Access Journals (Sweden)

    Manoussaridis Jordan T

    2006-08-01

    Full Text Available Abstract Background Mediastinal cysts compromise almost 20% of all mediastinal masses with bronchogenic subtype accounting for 60% of all cystic lesions. Although compression of adjoining soft tissues is usual, spinal complications and neurological symptoms are outmost rare and tend to characterize almost exclusively the neuroenteric cysts. Case presentation A young patient with intermittent, dull pain in his back and free medical history presented in the orthopaedic department of our hospital. There, the initial clinical and radiologic evaluation revealed a mediastinal mass and the patient was referred to the thoracic surgery department for further exploration. The following computed tomography (CT and magnetic resonance imaging (MRI shown a huge mediastinal cyst compressing the T4-T6 vertebral bodies. The neurological symptoms of the patient were attributed to this specific pathology due to the complete agreement between the location of the cyst and the nervous rule area of the compressed thoracic vertebrae. Despite our strongly suggestions for surgery the patient denied any treatment. Conclusion In controversy with the common faith that the spine plays the role of the natural barrier to the further expansion of cystic lesions, our case clearly indicates that, exceptionally, mediastinal cysts may cause severe vertebral complications. Therefore, early excision should be considered especially in young patients or where close follow up is uncertain.

  9. A probabilistic algorithm for interactive huge genome comparison.

    Science.gov (United States)

    Courtois, P R; Moncany, M L

    1995-12-01

    We designed a new probabilistic algorithm, named PAGEC (probabilistic algorithm for genome comparison), which allowed a highly interactive study of long genomic strings. The comparison between two nucleic acid sequences is based on the creation of multiple index tables, which drastically reduces processing time for huge genomes, e.g. 13 min for a 4 Mb/4 Mb comparison. PAGEC lowered the need for memory when compared with other types of algorithm and took into account the low resolution of the final representation (paper or computer screen). Considering that standard printers permit a 300 d.p.i. resolution, the loss of computed information due to the probabilistic conception of the algorithm was not usually noticeable in the present study, mainly due to increased genomic sizes. Refinement was possible through an interactive zooming system, which enabled the visualization of the lexical base sequences of a considered part of both of the studied genomes. Biological examples of computation based on yeast and animal nucleic acid sequences presented in this paper reveal the flexibility of the PAGEC program, which is a valuable tool for genetic studies as it offers a solution to an important problem that will become even more important as time passes.

  10. Looking for Giant Earths in the HD 209458 System: A Search for Transits in MOST Space-based Photometry

    CERN Document Server

    Croll, B; Rowe, J F; Kuschnig, R; Walker, A; Gladman, B; Sasselov, D; Cameron, C; Walker, G A H; Lin, D N C; Günther, D B; Moffat, A F J; Rucinski, S M; Weiss, W W; Croll, Bryce; Matthews, Jaymie M.; Rowe, Jason F.; Kuschnig, Rainer; Walker, Andrew; Gladman, Brett; Sasselov, Dimitar; Cameron, Chris; Walker, Gordon A. H.; Lin, Douglas N. C.; Guenther, David B.; Moffat, Anthony F. J.; Rucinski, Slavek M.; Weiss, Werner W.

    2007-01-01

    We have made a comprehensive transit search for exoplanets down to about 2 Earth radii in the HD 209458 system, based on nearly uninterrupted broadband optical photometry obtained with the MOST (Microvariability and Oscillations of Stars) satellite, spanning 14 days in 2004 and 44 days in 2005. We have searched these data for limb-darkened transits at periods other than that of the known giant planet, from about 0.5 days to 2 weeks. Monte Carlo statistical tests of the data with synthetic transits inserted allow us to rule out additional close-in exoplanets with sizes ranging from about 0.20-0.36 RJ (Jupiter radii), or 2.2-4.0 RE (Earth radii) on orbits whose planes are near that of HD 209458b. These null results constrain theories that invoke lower mass planets in orbits similar to HD 209458b to explain its anomalously large radius, and those that predict "hot Earths" due to the inward migration of HD 209458b.

  11. Search for CP violation in the phase space of D0→π+π−π+π− decays

    Directory of Open Access Journals (Sweden)

    R. Aaij

    2017-06-01

    Full Text Available A search for time-integrated CP violation in the Cabibbo-suppressed decay D0→π+π−π+π− is performed using an unbinned, model-independent technique known as the energy test. This is the first application of the energy test in four-body decays. The search is performed for P-even CP asymmetries and, for the first time, is extended to probe the P-odd case. Using proton–proton collision data corresponding to an integrated luminosity of 3.0 fb−1 collected by the LHCb detector at centre-of-mass energies of s=7 TeV and 8 TeV, the world's best sensitivity to CP violation in this decay is obtained. The data are found to be consistent with the hypothesis of CP symmetry with a p-value of (4.6±0.5% in the P-even case, and marginally consistent with a p-value of (0.6±0.2% in the P-odd case, corresponding to a significance for CP non-conservation of 2.7 standard deviations.

  12. Looking for Super-Earths in the HD 189733 System: A Search for Transits in Most Space-Based Photometry

    CERN Document Server

    Croll, Bryce; Rowe, Jason F; Gladman, Brett; Miller-Ricci, Eliza; Sasselov, Dimitar; Walker, Gordon A H; Kuschnig, Rainer; Lin, Douglas N C; Guenther, David B; Moffat, Anthony F J; Rucinski, Slavek M; Weiss, Werner W

    2007-01-01

    We have made a comprehensive transit search for exoplanets down to ~1.5 - 2 Earth radii in the HD 189733 system, based on 21-days of nearly uninterrupted broadband optical photometry obtained with the MOST (Microvariability & Oscillations of STars) satellite in 2006. We have searched these data for realistic limb-darkened transits from exoplanets other than the known hot Jupiter, HD 189733b, with periods ranging from about 0.4 days to one week. Monte Carlo statistical tests of the data with synthetic transits inserted into the data-set allow us to rule out additional close-in exoplanets with sizes ranging from about 0.15 - 0.31 RJ (Jupiter radii), or 1.7 - 3.5 RE (Earth radii) on orbits whose planes are near that of HD 189733b. These null results constrain theories that invoke lower-mass hot Super-Earth and hot Neptune planets in orbits similar to HD 189733b due to the inward migration of this hot Jupiter. This work also illustrates the feasibility of discovering smaller transiting planets around chromosp...

  13. The next bit thing in physics is huge and costly

    CERN Multimedia

    Overbye, Dennis

    2007-01-01

    The price of exploring inner space went up. An international consortium of physicists proposed the next big thing in physics: the International Linear Collider and it would cost about $ 6.7 billion. (1 page)

  14. Ohya Large Holography Studio In A Huge Rock Cavern

    Science.gov (United States)

    Watanabe, K.; Hirosawa, A.; Morie, T.; Suzuki, M.; Yamashita, H.

    1988-01-01

    There is a great demand recently for a large size hologram, 2meters width for instance, in which a brand-new car, a life-size statue and sometimes a group of the them, or interior spaces could he taken. Especially, in the world of advertisement or art, there is a big demand for a large hologram. The larger hologram needs the larger space for its suitable holography. This is the report of a large underground studio built in Japan.

  15. MRI Verification of a Case of Huge Infantile Rhabdomyoma

    Science.gov (United States)

    Ramadani, Naser; Kreshnike, Kreshnike Dedushi; Muçaj, Sefedin; Kabashi, Serbeze; Hoxhaj, Astrit; Jerliu, Naim; Bejiçi, Ramush

    2016-01-01

    Introduction: Cardiac rhabdomyoma is type of benign myocardial tumor that is the most common fetal cardiac tumor. Cardiac rhabdomyomas are usually detected before birth or during the first year of life. They account for over 60% of all primary cardiac tumors. Case report: A 6 month old child with coughing and obstruction in breathing, was hospitalized in the Pediatric Clinic in UCCK, Pristine. The difficulty of breathing was heard and the pathological noise of the heart was noticed from the pediatrician. In the echo of the heart at the posterior and apico-lateral part of the left ventricle a tumoral mass was presented with the dimensions of 56 × 54 mm that forwarded the contractions of the left ventricle, the mass involved also the left ventricle wall and was not vascularized. The right ventricle was deformed and with the shifting of the SIV on the right the contractility was preserved. Aorta, the left arch and AP were normal with laminar circulation. The pericard was presented free. Radiography of thoracic organs was made; it resulted on cardiomegaly and significant bronchovascular drawing. It was completed with an MRI and it resulted on: Cardiomegaly due to large tumoral mass lesion (60×34 mm) involving lateral wall of left ventricle. It was isointense to the muscle on T1W images, markedly hyperintense on T2W images. There were a few septa or bant like hypointensities within lesion. On postcontrast study it showed avid enhancement. The left ventricle volume was decreased. Mild pericardial effusion was also noted. Surgical intervention was performed and it resulted on the histopathological aspect as a huge infantile rhadbomyoma. Conclusion: In most cases no treatment is required and these lesions regress spontaneously. Patients with left ventricular outflow tract obstruction or refractory arrhythmias respond well to surgical excision. Rhabdomyomas are frequently diagnosed by means of fetal echocardiography during the prenatal period. PMID:27147810

  16. Single-Path Sigma from a Huge Dataset in Taiwan

    Science.gov (United States)

    Sung, Chih-Hsuan; Lee, Chyi-Tyi

    2014-05-01

    Ground-motion variability, which was used in the probabilistic seismic hazard analysis (PSHA) in computing annual exceedence probability, is composed of random variability (aleatory uncertainty) and model uncertainty (epistemic uncertainty). Finding random variability of ground motions has become an important issue in PSHA, and only the random variability can be used in deriving the annual exceedence probability of ground-motion. Epistemic uncertainty will be put in the logic tree to estimate the total uncertainty of ground-motion. In the present study, we used about 18,859 records from 158 shallow earthquakes (Mw > 3.0, focal depth ≤ 35 km, each station has at least 20 records) form the Taiwan Strong-Motion Instrumentation Program (TSMIP) network to analyse the random variability of ground-motion. First, a new ground-motion attenuation model was established by using this huge data set. Second, the residuals from the median attenuation were analysed by direct observation on inter-event variability and site-specific variability. Finally, the single-path variability was found by a moving-window method on either single-earthquake residuals or single-station residuals. A variogram method was also used to find minimum variability for intra-event residuals and inter-event residuals, respectively. Results reveal that 90% of the single-path sigma σSP are ranging from 0.219 to 0.254 (ln unit) and are 58% to 64% smaller than the total sigma (σT =0.601). The single-site sigma (σSS) are also 39%-43% smaller. If we use only random variability (single-path sigma) in PSHA, then the resultant hazard level would be 28% and 25% lower than the traditional one (using total sigma) in 475-year and in 2475-year return period, respectively, in Taipei.

  17. Improving 3D spatial queries search: newfangled technique of space filling curves in 3D city modeling

    DEFF Research Database (Denmark)

    Uznir, U.; Anton, François; Suhaibah, A.

    2013-01-01

    web standards. However, these 3D city models consume much more storage compared to two dimensional (2D) spatial data. They involve extra geometrical and topological information together with semantic data. Without a proper spatial data clustering method and its corresponding spatial data access method......, retrieving portions of and especially searching these 3D city models, will not be done optimally. Even though current developments are based on an open data model allotted by the Open Geospatial Consortium (OGC) called CityGML, its XML-based structure makes it challenging to cluster the 3D urban objects...... modeling will improve data retrieval time by means of optimized 3D adjacency, nearest neighbor information and 3D indexing. The Hilbert mapping, which maps a subinterval of the [0, 1] interval to the corresponding portion of the d-dimensional Hilbert’s curve, preserves the Lebesgue measure and is Lipschitz...

  18. “I Am Human Too!” ‘Probeerruimte’ as Liminal Spaces in Search of Recognition

    Directory of Open Access Journals (Sweden)

    Fiona MacLeod Budge

    2016-11-01

    Full Text Available This paper explores the Dutch concept ‘probeerruimte’ in relation to the statement ‘human as a contested concept’, a highly relevant topic in disability studies. Probeerruimte encompasses the idea that people need space to ‘try things out’, a liminal space that facilitates personal development. It was conceived in a context where institutional practices exerted restrictive control over the lives of people with learning difficulties, denying them rights to self-determination and personal growth, rights that are integral to experiences of ‘being human’. The concept emerged about 20 years ago, and was revived during two studies conducted in 2014 and 2015.  The studies, commissioned by Disability Studies in Nederland (DSiN, explored perceptions of social inclusion. Study findings reveal the significance of associated concepts, inclusive of connectivity, citizenship, liminal spaces, and ‘risk taking’. Of critical importance is the need to challenge hegemonic practices that all too often disempower people with learning difficulties, remove their rights and, relegate their status to below citizenship. This paper addresses the relevance of probeerruimte for people with learning difficulties, from their perspectives, and examines how institutions can facilitate this process. Opinions from ‘all people’ involved in the conversation are used as data so as not to ‘label’ or make too strict a distinction between people with or without learning difficulties. The authors affirm the need to create probeerruimte to facilitate varied ways of existing. Ideally these ways of existing will promote opportunities for people with learning difficulties to engage in meaningful spaces, affirm their rights to citizenship and recognise their humanity.

  19. Spaces

    Directory of Open Access Journals (Sweden)

    Maziar Nekovee

    2010-01-01

    Full Text Available Cognitive radio is being intensively researched as the enabling technology for license-exempt access to the so-called TV White Spaces (TVWS, large portions of spectrum in the UHF/VHF bands which become available on a geographical basis after digital switchover. Both in the US, and more recently, in the UK the regulators have given conditional endorsement to this new mode of access. This paper reviews the state-of-the-art in technology, regulation, and standardisation of cognitive access to TVWS. It examines the spectrum opportunity and commercial use cases associated with this form of secondary access.

  20. Fidgety movements – tiny in appearance, but huge in impact

    Directory of Open Access Journals (Sweden)

    Christa Einspieler

    2016-06-01

    Full Text Available Abstract Objectives: To describe fidgety movements (FMs, i.e., the spontaneous movement pattern that typically occurs at 3–5 months after term age, and discuss its clinical relevance. Sources: A comprehensive literature search was performed using the following databases: MEDLINE/PubMed, CINAHL, The Cochrane Library, Science Direct, PsycINFO, and EMBASE. The search strategy included the MeSH terms and search strings (‘fidgety movement*’ OR [(‘general movement*’ AND (‘three month*’ OR (‘3 month*’], as well as studies published on the General Movements Trust website (www.general-movements-trust.info. Summary of the data: Virtually all infants develop normally if FMs are present and normal, even if their brain ultrasound findings and/or clinical histories indicate a disposition to later neurological deficits. Conversely, almost all infants who never develop FMs have a high risk for neurological deficits such as cerebral palsy, and for genetic disorders with a late onset. If FMs are normal but concurrent postural patterns are not age-adequate or the overall movement character is monotonous, cognitive and/or language skills at school age will be suboptimal. Abnormal FMs are unspecific and have a low predictive power, but occur exceedingly in infants later diagnosed with autism. Conclusions: Abnormal, absent, or sporadic FMs indicate an increased risk for later neurological dysfunction, whereas normal FMs are highly predictive of normal development, especially if they co-occur with other smooth and fluent movements. Early recognition of neurological signs facilitates early intervention. It is important to re-assure parents of infants with clinical risk factors that the neurological outcome will be adequate if FMs develop normally.

  1. Pulmonary hypertension with a huge thrombosis in main stem of pulmonary artery

    Institute of Scientific and Technical Information of China (English)

    杨萍; 曾红; 孟繁波; 赵林阳

    2001-01-01

    @@A huge thrombosis in the main stem of the pulmonary artery (PA) with pulmonary hypertension has rarely been reported. We present two cases diagnosed and treated in our hospital. One suffered from polyarteritis with a huge thrombus in PA revealed at autopsy. The second case had congenital heart disease of the patent artery duct; and the huge thrombus was found on echocardiogram and extirpated in surgery.

  2. Huge ascending aortic aneurysm with an intraluminal thrombus in an embolic event-free patient.

    Science.gov (United States)

    Parato, Vito Maurizio; Prifti, Edvin; Pezzuoli, Franco; Labanti, Benedetto; Baboci, Arben

    2015-03-01

    We present a case of an 87-year-old male patient with a huge ascending aortic aneurysm, filled by a huge thrombus most probably due to previous dissection. This finding was detected by two-dimensional transthoracic echocardiography and contrast-enhanced computed tomography (CT) angiography scan. The patient refused surgical treatment and was medically treated. Despite the huge and mobile intraluminal thrombus, the patient remained embolic event-free up to 6 years later, and this makes the case unique.

  3. Highly flexible nearest-neighbor-search associative memory with integrated k nearest neighbor classifier, configurable parallelism and dual-storage space

    Science.gov (United States)

    An, Fengwei; Mihara, Keisuke; Yamasaki, Shogo; Chen, Lei; Jürgen Mattausch, Hans

    2016-04-01

    VLSI-implementations are often applied to solve the high computational cost of pattern matching but have usually low flexibility for satisfying different target applications. In this paper, a digital word-parallel associative memory architecture for k nearest neighbor (KNN) search, which is one of the most basic algorithms in pattern recognition, is reported applying the squared Euclidean distance measure. The reported architecture features reconfigurable parallelism, dual-storage space to achieve a flexible number of reference vectors, and a dedicated majority vote circuit. Programmable switching circuits, located between vector components, enable scalability of the searching parallelism by configuring the reference feature-vector dimensionality. A pipelined storage with dual static-random-access-memory (SRAM) cells for each unit and an intermediate winner control circuit are designed to extend the applicability by improving the flexibility of the reference storage. A test chip in 180 nm CMOS technology, which has 32 rows, 4 elements in each row and 2-parallel 8-bit dual-components in each element, consumes altogether 61.4 mW and in particular only 11.9 mW during the reconfigurable KNN classification (at 45.58 MHz and 1.8 V).

  4. A search for transits of GJ 581\\lowercase{e} and characterization of the host star variability using MOST space telescope photometry

    CERN Document Server

    Dragomir, Diana; Kuschnig, Rainer; Rowe, Jason F; Gladman, Brett J; Guenther, David B; Moffat, Anthony F J; Rucinski, Slavek M; Sasselov, Dimitar; Weiss, Werner W

    2012-01-01

    The GJ 581 system has been amply studied since its discovery in 2005: the number of known planets in the system has increased and their orbital parameters are among the most precisely determined for radial velocity detected exoplanets. We have acquired MOST space-based photometry during 2007 and 2009, with the aims of measuring the stellar variability and searching for transits of GJ 581e, respectively. We quantify our sensitivity to shallow transit signals using Monte Carlo simulations, and perform a transit search within the 3$\\sigma$ transit windows corresponding to both the circular and Keplerian orbit ephemerides. Our analysis rules out transits for a planet with an orbital period of 3.15 days (GJ 581 e) having a radius larger than 1.62 $R_{\\oplus}$ (or a density lower than 2.39 g cm$^{-3}$ for an orbital inclination of 90$^{\\circ}$) to 2$\\sigma$ confidence. Thus, if the planet transits, we can exclude hydrogen, helium and water theoretical model compositions. The MOST photometry also allows us to rule o...

  5. Model independent search for new particles in two-dimensional mass space using events with missing energy, two jets and two leptons with the CMS detector

    CERN Document Server

    AUTHOR|(CDS)2080070; Hebbeker, Thomas

    2017-07-07

    The discovery of a new particle consistent with the standard model Higgs boson at the Large Hadron Collider in 2012 completed the standard model of particle physics (SM). Despite its remarkable success many questions remain unexplained. Numerous theoretical models, predicting the existence of new heavy particles, provide answers to these unresolved questions and are tested at high energy experiments such as the Compact Muon Solenoid (CMS) detector at the Large Hadron Collider (LHC). In this thesis a model independent search method for new particles in two-dimensional mass space in events with missing transverse energy is presented using 19.7 $\\mbox{fb}^{-1}$ of proton-proton collision data recorded by the CMS detector at a centre of mass energy $\\sqrt{s}$ = 8 TeV at the LHC. The analysis searches for signatures of pair-produced new heavy particles $\\mbox{T}^\\prime$ which decay further into unknown heavy particles $\\mbox{W}^\\prime$ and SM quarks $q$ ($\\mbox{T}^\\prime\\overline{\\mbox{T}^\\prime} \\rightarrow {...

  6. Efficacy of hepatic resection for huge (≥ 10 cm) hepatocellular carcinoma: good prognosis associated with the uninodular subtype.

    Science.gov (United States)

    Zhu, Shao-Liang; Chen, Jie; Li, Hang; Li, Le-Qun; Zhong, Jian-Hong

    2015-01-01

    The value of hepatic resection (HR) for huge hepatocellular carcinomas (HCC) (≥ 10 cm in diameter) remains controversial. The aim of this study is to evaluate the efficacy of hepatic resection (HR) for patients with huge HCC. A total of 739 patients with huge HCC (≥ 10 cm in diameter) (huge HCC group, n = 244) or small HCC (huge HCC were identified based on Cox regression analyses. The hospital mortality of these two groups were similar (P = 0.252). The 5-year OS of huge HCC group and small HCC group were 30.3% and 51.9%, respectively (P huge HCC had a significant higher 5-year OS (50.6%) than mutinodular huge HCC (26.9%) (P = 0.016). Multivariate analysis revealed that uninodular huge HCC and absence of PVTT independently predicted better OS for huge HCC patients. HR is a safe and effective approach for the treatment of huge HCC, especially for the uninodular subtype.

  7. Multiple Simulated Annealing-Molecular Dynamics (MSA-MD) for Conformational Space Search of Peptide and Miniprotein.

    Science.gov (United States)

    Hao, Ge-Fei; Xu, Wei-Fang; Yang, Sheng-Gang; Yang, Guang-Fu

    2015-10-23

    Protein and peptide structure predictions are of paramount importance for understanding their functions, as well as the interactions with other molecules. However, the use of molecular simulation techniques to directly predict the peptide structure from the primary amino acid sequence is always hindered by the rough topology of the conformational space and the limited simulation time scale. We developed here a new strategy, named Multiple Simulated Annealing-Molecular Dynamics (MSA-MD) to identify the native states of a peptide and miniprotein. A cluster of near native structures could be obtained by using the MSA-MD method, which turned out to be significantly more efficient in reaching the native structure compared to continuous MD and conventional SA-MD simulation.

  8. Huge pelvi-abdominal malignant inflammatory myofibroblastic tumor with rapid recurrence in a 14-year-old boy

    Institute of Scientific and Technical Information of China (English)

    Chia-Hsun; Lu; Hsuan-Ying; Huang; Han-Koo; Chen; Jiin-Haur; Chuang; Shu-Hang; Ng; Sheung-Fat; Ko

    2010-01-01

    Inflammatory myofibroblastic tumor(IMT) is an uncommon benign neoplasm with locally aggressive behavior but malignant change is rare.We report an unusual case of pelvic-abdominal inflammatory myofibroblastic tumor with malignant transformation in a 14-year-old boy presenting with abdominal pain and 9 kg body weight loss in one month.Computed tomography revealed a huge pelvi-abdominal mass(30 cm),possibly originating from the pelvic extraperitoneal space,protruding into the abdomen leading to upward displace...

  9. [Huge benign lung tumor in a female smoker].

    Science.gov (United States)

    Smati, B; Ismail, O; Boudaya, M S; Baccari, S; Djilani, H; Mestiri, T; El Mezni, F; Gharbi, L; Kilani, T

    2005-12-01

    Pulmonary sclerosing hemangioma is a rare, slow-growing, benign tumor. Its potential for progression and its histiogenesis remains controversial. A routine chest X-ray revealed a right abdominal mass in 41-year-old woman. Search for a cause was negative. The patient underwent posterolateral thoracotomy for tumorectomy. Intraoperative pathology analysis revealed the benign nature of the tumor. No complication was observed postoperatively. The final pathological conclusion was sclerosing hemangioma of the lung. Pulmonary sclerosing hemangioma is a parenchymal tumor of the lung. The latest immunohistochemical studies of this lesion suggest a pneumocyte origin. Prognosis is good, but extension to lymph nodes may occur. Surgery is always required for cure, and must be associated with lymph node dissection for large tumors.

  10. Efficient visualization of unsteady and huge scalar and vector fields

    Science.gov (United States)

    Vetter, Michael; Olbrich, Stephan

    2016-04-01

    The simulation of climate data tends to produce very large data sets, which hardly can be processed in classical post-processing visualization applications. Within the most traditional post-processing scenarios the visualization pipeline consisting of the processes data generation, visualization mapping and rendering is distributed into two parts over the network or separated via file transfer: the data generation on a supercomputer on the one hand and the other tasks on a special visualization system on the other hand. That way either temporary data sets with huge volume have to be transferred over the network, which leads to bandwidth bottlenecks and volume limitations. As an alternative all simulation and visualization processes are integrated in a monolithic application, where just 2D pixel data is stored, which reduces the user's possibilities for 3D interaction with visualization to frame skipping. Within the Climate Visualization Lab - as part of the Cluster of Excellence "Integrated Climate System Analysis and Prediction" (CliSAP at the University of Hamburg, in cooperation with the German Climate Computing Center (DKRZ) - we plan to integrate a different approach, which has been proven to be successful in former meteorology applications, e.g. PALM (Parallel Large Eddy Simulation Model). Our software framework DSVR is based on the separation of the process chain between the mapping and the rendering processes. We have developed a parallelized visualization library based on MPI and evaluated on various supercomputers. DSVR can be used to integrate the visualization into a parallel simulation model to support in-situ processing, resulting in a sequence of time-based geometric 3D objects which can be interactively rendered in a separate 3D viewer application. To meet the actual requirements (a) to visualize existing data sets, (b) to support more than rectilinear grids, and (c) to integrate in-situ processing in the ICON model, all based on our DSVR framework

  11. HUBBLE SPIES HUGE CLUSTERS OF STARS FORMED BY ANCIENT ENCOUNTER

    Science.gov (United States)

    2002-01-01

    NASA's Hubble Space Telescope snapped these two views of the heart of the galaxy M82. The image at left was taken in visible light; the picture at right, in infrared light. In the infrared view, the telescope's Near Infrared Camera and Multi-Object Spectrometer peered through thick dust lanes to find some of the galaxy's more than 100 super star clusters. The clusters are the larger pink and yellow dots scattered throughout the picture. They were formed during a violent collision with the galaxy M81 about 600 million years ago. The galaxy is 12 million light-years from Earth in the constellation Ursa Major. The pictures were taken Sept. 15, 1997. Credits: NASA, ESA, R. de Grijs (Institute of Astronomy, Cambridge, UK) NOTE TO EDITORS: For additional information, please contact Richard de Grijs, Institute of Astronomy, Cambridge University, Madingley Road, Cambridge CB3 0HA, UK, +44(0)1223-337528 (phone), +44(0)1223-337523 (fax), grijs@ast.cam.ac.uk (e-mail). The Space Telescope Science Institute (STScI) is operated by the Association of Universities for Research in Astronomy, Inc. (AURA), for NASA, under contract with the Goddard Space Flight Center, Greenbelt, MD. The Hubble Space Telescope is a project of international cooperation between NASA and the European Space Agency (ESA). This image is issued jointly by NASA and ESA. Electronic images, animation and additional information are available at: http://oposite.stsci.edu/pubinfo/pr/2001/08 and via links in http://oposite.stsci.edu/pubinfo/latest.html http://oposite.stsci.edu/pubinfo/pictures.html http://hubble.stsci.edu/go/news http://hubble.esa.int To receive STScI press releases electronically, send an Internet electronic mail message to public-request@stsci.edu. Leave the subject line blank, and type the word subscribe in the body of the message. The system will respond with a confirmation of the subscription, and you will receive new press releases as they are issued. Please subscribe using the email account

  12. A Novel Shrinking Search Space (SSS) Genetic Algorithm based approach to Security Constrained Optimal Power Flow%基于启发搜索空间遗传算法的安全控制最优潮流方法

    Institute of Scientific and Technical Information of China (English)

    Mithun M Bhasskar; Mohan Benerji; Sydulu M

    2011-01-01

    This paper proposes a new superior genetic algorithm with faster convergence applied to the Security constrained Optimal Power Flow problem. A novel Shrinking Search Space (SSS) technique is applied, which reduces the computational burden and affluence the search space every iteration is put forward. The proposed algorithm is compared with conventional techniques like Simple Genetic Algorithm (SGA) , Adaptive Genetic Algorithm (AGA) , Particle Swarm Technique (PSO) and Differential Evolution (DE) to prove its robustness. Case studies with and without (N - 1) contingency of a line outage are analyzed by proposed algorithm on a test bed of standard IEEE 30 bus system and it's found the proposed technique offers a promising prospect for optimization problems.

  13. The LiteBIRD Space Mission and the Search for Inflation at the Beginning of the Universe

    Science.gov (United States)

    Lee, Adrian T.

    2016-06-01

    Inflation is the leading theory to explain the first instant of the universe. The case for inflationis building, and now we may have the opportunity to observe the signature of gravitational waves from the inflation event embedded in the cosmic microwave background. If seen, these signals would confirm inflation, point to the correct model for inflation,and, given the high energies involved, teach us about fundamental physics such as quantum gravity and string theory. I will describe the LiteBIRD cosmic microwave background space mission which is currently in collaborative Phase A studies in both Japanand the U.S. LiteBIRD will use a 50 cm diameter telescope and a ~2000 detector focal plane cooled to 100 mK to probe degree and larger angular scales in polarization. It will measure the entire sky with ~2 microK*arcmin noise (150 GHz), and measure in 15 bands from 40 to 400 GHz to measure and subtract foregrounds. A rapidly spinning Half-Wave Plate will be used to rapidly “chop” between two polarization states. It will orbit at the second Lagrange point (L2).

  14. Quantum searching application in search based software engineering

    Science.gov (United States)

    Wu, Nan; Song, FangMin; Li, Xiangdong

    2013-05-01

    The Search Based Software Engineering (SBSE) is widely used in software engineering for identifying optimal solutions. However, there is no polynomial-time complexity solution used in the traditional algorithms for SBSE, and that causes the cost very high. In this paper, we analyze and compare several quantum search algorithms that could be applied for SBSE: quantum adiabatic evolution searching algorithm, fixed-point quantum search (FPQS), quantum walks, and a rapid modified Grover quantum searching method. The Grover's algorithm is thought as the best choice for a large-scaled unstructured data searching and theoretically it can be applicable to any search-space structure and any type of searching problems.

  15. Fibrous dysplasia of the rib presenting as a huge chest wall tumor: report of a case.

    Science.gov (United States)

    Chang, B S; Lee, S C; Harn, H J

    1994-07-01

    Fibrous dysplasia of the rib is not uncommon, but is rarely demonstrated as a huge chest wall mass with severe clinical symptoms. A 59-year-old patient, presenting with a huge, rapidly expanding chest wall tumor compressing the lung, liver and heart accompanied by chest pain and dyspnea, is reported. The tumor was success-fully excised by local radical resection.

  16. Huge van Bordeeus : een ridder van Karel de Grote op avontuur in het Oosten

    NARCIS (Netherlands)

    Lens, Maria Johanna

    2004-01-01

    'Huge van Bordeeus' is de dissertatie van Maria Lens. Hierin doet zij verslag van haar onderzoek naar de Middelnederlandse overlevering van een Franse tekst, 'Huon de Bordeaux', over de ridder Huge van Bordeeus. Deze veertiende-eeuwse ridder, leenman van Karel de Grote, moet de baard en vier tanden

  17. Stringent constraints on the dark matter annihilation cross section from subhalo searches with the Fermi Gamma-Ray Space Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Berlin, Asher; Hooper, Dan

    2014-01-01

    The dark matter halo of the Milky Way is predicted to contain a very large number of smaller subhalos. As a result of the dark matter annihilations taking place within such objects, the most nearby and massive subhalos could appear as point-like or spatially extended gamma-ray sources, without observable counterparts at other wavelengths. In this paper, we use the results of the Aquarius simulation to predict the distribution of nearby subhalos, and compare this to the characteristics of the unidentified gamma-ray sources observed by the Fermi Gamma-Ray Space Telescope. Focusing on the brightest high latitude sources, we use this comparison to derive limits on the dark matter annihilation cross section. For dark matter particles lighter than ~200 GeV, the resulting limits are the strongest obtained to date, being modestly more stringent than those derived from observations of dwarf galaxies or the Galactic Center. We also derive independent limits based on the lack of unidentified gamma-ray sources with discernible spatial extension, but these limits are a factor of ~2-10 weaker than those based on point-like subhalos. Lastly, we note that four of the ten brightest high-latitude sources exhibit a similar spectral shape, consistent with 30-60 GeV dark matter particles annihilating to b quarks with an annihilation cross section on the order of sigma v ~ (5-10) x 10^-27 cm^3/s, or 8-10 GeV dark matter particles annihilating to taus with sigma v ~ (2.0-2.5) x 10^-27 cm^3/s.

  18. The effects of task difficulty, novelty and the size of the search space on intrinsically motivated exploration

    Directory of Open Access Journals (Sweden)

    Adrien Fredj Baranes

    2014-10-01

    Full Text Available Devising efficient strategies for exploration in large open-ended spaces is one of the most difficult computational problems of intelligent organisms. Because the available rewards are ambiguous or unknown during the exploratory phase, subjects must act in intrinsically motivated fashion. However, a vast majority of behavioral and neural studies to date have focused on decision making in reward-based tasks, and the rules guiding intrinsically motivated exploration remain largely unknown. To examine this question we developed a paradigm for systematically testing the choices of human observers in a free play context. Adult subjects played a series of short computer games of variable difficulty, and freely choose which game they wished to sample without external guidance or physical rewards. Subjects performed the task in three distinct conditions where they sampled from a small or a large choice set (7 vs 64 possible levels of difficulty, and where they did or did not have the possibility to sample new games at a constant level of difficulty. We show that despite the absence of external constraints, the subjects spontaneously adopted a structured exploration strategy whereby they (1 started with easier games and progressed to more difficult games, (2 sampled the entire choice set including extremely difficult games that could not be learnt, (3 repeated moderately and high difficulty games much more frequently than was predicted by chance, and (4 had higher repetition rates and chose higher speeds if they could generate new sequences at a constant level of difficulty. The results suggest that intrinsically motivated exploration is shaped by several factors including task difficulty, novelty and the size of the choice set, and these come into play to serve two internal goals - maximize the subjects’ knowledge of the available tasks (exploring the limits of the task set, and maximize their competence (performance and skills across the task set.

  19. The effects of task difficulty, novelty and the size of the search space on intrinsically motivated exploration.

    Science.gov (United States)

    Baranes, Adrien F; Oudeyer, Pierre-Yves; Gottlieb, Jacqueline

    2014-01-01

    Devising efficient strategies for exploration in large open-ended spaces is one of the most difficult computational problems of intelligent organisms. Because the available rewards are ambiguous or unknown during the exploratory phase, subjects must act in intrinsically motivated fashion. However, a vast majority of behavioral and neural studies to date have focused on decision making in reward-based tasks, and the rules guiding intrinsically motivated exploration remain largely unknown. To examine this question we developed a paradigm for systematically testing the choices of human observers in a free play context. Adult subjects played a series of short computer games of variable difficulty, and freely choose which game they wished to sample without external guidance or physical rewards. Subjects performed the task in three distinct conditions where they sampled from a small or a large choice set (7 vs. 64 possible levels of difficulty), and where they did or did not have the possibility to sample new games at a constant level of difficulty. We show that despite the absence of external constraints, the subjects spontaneously adopted a structured exploration strategy whereby they (1) started with easier games and progressed to more difficult games, (2) sampled the entire choice set including extremely difficult games that could not be learnt, (3) repeated moderately and high difficulty games much more frequently than was predicted by chance, and (4) had higher repetition rates and chose higher speeds if they could generate new sequences at a constant level of difficulty. The results suggest that intrinsically motivated exploration is shaped by several factors including task difficulty, novelty and the size of the choice set, and these come into play to serve two internal goals-maximize the subjects' knowledge of the available tasks (exploring the limits of the task set), and maximize their competence (performance and skills) across the task set.

  20. Biochemical assessment of the hibernator skeletal muscle properties in search of a potential countermeasure against muscle atrophy in space microgravity

    Science.gov (United States)

    Lee, K.; Park, J. Y.; Gwag, T.; Yoo, W.; Choi, I.

    Mammalian skeletal muscle undergoes significant loss of mass and tension capacity during spaceflight or hindlimb suspension This is contrasted by observed features of hibernators in that muscle mass and contractility remain fairly unchanged during a prolonged period of dormancy In an effort of finding potential countermeasure against muscle atrophy in space microgravity we thereby investigated the biochemical properties of the pectoral muscle in a winter-hibernating bat Murina leucogaster Two-dimensional electrophoresis on overall muscle proteins and western blot analysis on heat shock proteins HSP 60 kD 70 kD and 90 kD were conducted to compare levels of myofiber proteins and the stress responsive chaperone molecules in winter-hibernation WH versus summer-active bats SA No seasonal difference was found in the ratio of muscle mass to body mass for the pectoral muscles confirming similar results in previous reports Among more than thirty proteins identified only 14 of the proteins showed significant reduction in the level for WH compared to SA The level of HSP60 and HSP90 in WH were 63 and 71 that in SA respectively P quad 0 05 whereas that of HSP70 was not different between the two groups However when the WH were forced to arouse for 40 min from hibernation the level of HSP70 increased 1 4-fold and 1 51-fold that of WH and SA respectively while the level of HSP90 increased 1 57-fold that of WH These results suggest that the levels of many key contractile and regulatory proteins were retained during

  1. Transarterial chemoembolization for huge hepatocellular carcinoma with diameter over ten centimeters: a large cohort study.

    Science.gov (United States)

    Xue, Tongchun; Le, Fan; Chen, Rongxin; Xie, Xiaoying; Zhang, Lan; Ge, Ningling; Chen, Yi; Wang, Yanhong; Zhang, Boheng; Ye, Shenglong; Ren, Zhenggang

    2015-03-01

    Patients with huge hepatocellular carcinoma >10 cm in diameter represent a special subgroup for treatment. To date, there are few data and little consensus on treatment strategies for huge hepatocellular carcinoma. In this study, we summarized the effects and safety of transarterial chemoembolization for huge hepatocellular carcinoma. A retrospective study was performed based on a large cohort of patients (n = 511) with huge hepatocellular carcinoma who underwent serial transarterial chemoembolization between January 2008 to December 2011 and were followed up until March 2013. We found median survival time was 6.5 months. On multivariate analysis, Child-Pugh class (A versus B) (p huge hepatocellular carcinoma and is recommended as a component of combination therapy. In addition, patients with good liver function and low alpha-fetoprotein levels may acquire greater survival benefits from transarterial chemoembolization.

  2. Huge New Telescope to Boost Hunt for Alien Life

    Institute of Scientific and Technical Information of China (English)

    Andrew; Quinn; 陈国凝

    2000-01-01

    微软公司的创始人之一Paul Allen和前微软公司的技术总监NathanMyhrvold慷慨出手,献出巨资,筹建大型的新望远镜Allen Telescope Array,对人类探索地球以外的智能生命助一臂之力。本文并未对两位捐助者歌功颂德,而对人类目前寻找地球以外的高级动物的探索作了详尽的介绍。许多信息鲜活感人。 人类探索地球外的高级动物的努力已经进行了四十余年,英语甚至收入了SETI(=search for extraterrestrial intelligence)这样的专用名词及其相应的组织。 以下两段文字值得注意: While the best scientific estimates tell us the probability of intelligent lifeelsewhere in the universe is fairly high, there is great uncertainty and somecontroversy in the calculation. One thing however, is beyond dispute. That is, if we don’t continuesupporting projects like the Allen Telescope Array, our chances of discovery willremain at zero. 预计在2005,Allen Telescope Array将投入使用。我们翘首盼望这一天的到来,更翘首盼望人类有朝一日能够发现人类并非茫茫宇宙之唯一,并能彻底揭开UFO一类的谜团。

  3. The Quest for Complex Molecules in Space. Searches for Cyanides Related to n-PROPYL Cyanide in SGR B2(N)

    Science.gov (United States)

    Müller, Holger S. P.; Schlemmer, S.; Belloche, A.; Menten, K. M.; Coutens, A.; Walters, A.; Grabow, J.-U.

    2011-06-01

    A molecular line survey was carried out with the IRAM 30 m telescope toward the prolific hot core Sgr B2(N) in order to explore its molecular complexity. The entire 3 mm range as well as selected regions at 2 and 1.3 mm were covered. Notable results include the detections of aminoacetonitrile, ethyl formate, n-propyl cyanide,^b and the singly substituted 13C isotopologs of vinyl cyanide. There exists a branched isomer of n-propyl cyanide: iso-propyl cyanide. A search for this isomer in our line survey required a laboratory spectroscopic investigation beforehand. Even though promising emission features have been found for this as well as other, related molecules, there are rather few uncontaminated lines. Overlap by other emission or some absorption features occurs frequently, and uncertainties about the position of the baseline also contribute to considering detections to be inconclusive. Nevertheless, the determination of upper limits or abundances among isomers and related molecules will help to constrain astrochemical pathways. We will present our results and discuss promising strategies to search for complex molecules in space. A. Belloche, K. M. Menten, C. Comito, H. S. P. Müller, P. Schilke, J. Ott, S. Thorwirth, C. Hieret, Astron. Astrophys. 482 (2008) 179. A. Belloche, R. T. Garrod, H. S. P. Müller, K. M. Menten, C. Comito, P. Schilke, Astron. Astrophys. 499 (2009), 215. H. S. P. Müller, A. Belloche, K. M. Menten, C. Comito, P. Schilke, J. Mol. Spectrosc. 251 (2008) 319. H. S. P. Müller, A. Coutens, A. Walters, J.-U. Grabow, S. Schlemmer, submitted to J. Mol. Spectrosc.

  4. Cystic Endometriosis in a Huge Degenerated Subserous Leiomyoma Mimicking Bilateral Multicystic Endometriomas in an Infertile Woman with Diminished Ovarian Reserve: A Rare Endometriotic Implantation.

    Science.gov (United States)

    Hatirnaz, Safak; Colak, Sabri; Reis, Abdulkadir

    2016-01-01

    Uterine leiomyomas are the most common pelvic tumor in women. Leiomyoma can show atypical locations and degenerations and may not be easily differentiated from adnexal masses. Uterine leiomyoma can undergo cystic degeneration and is said to be found in 4% of all types of degenerations. The commonest type of degeneration is hyaline seen in 60% of patients. Usually uterine leiomyoma does not present as clinical and radiological diagnostic challenge. However, when leiomyoma undergoes massive cystic degeneration they may become clinical and radiological diagnostic dilemmas. The MRI showed a huge cystic mass protruding up to the pelvis not differentiated from bilateral endometriomas and accompanying subserous myomas. Surgery revealed that the mass is not bilateral endometriomas but a huge pedunculated leiomyoma with cystic degeneration and cystic endometriosis. Endometriosis is a troubling gynecologic condition occurring in 10% to 15% of women of reproductive age and is associated with fertility problems. As a peritoneal disease, the locations of endometriotic lesions are predominantly the ovaries (96.4%), followed by the soft tissue (2.8%), gastrointestinal tract (0.3%), and urinary tract (0.2%) and other rare locations. The presented case is multiple sized cystic endometriosis (endometriomas) located in a huge pedunculated subserous leiomyoma in an infertile woman having a history of laparoscopic bilateral endometrioma surgery. Conclusion. To our knowledge, this is the first reported case for endometriotic cysts (endometriomas) located in a huge cystic degenerated leiomyoma. PubMed search revealed no report concerning endometriotic implantation in the leiomyomas.

  5. Detection of a huge explosion in the early Universe

    CERN Document Server

    Cusumano, G; Chincarini, G; Panaitescu, A; Burows, D N; La Parola, V; Sakamoto, T; Campana, S; Mineo, T; Tagliaferri, G; Angelini, L; Barthelemy, S; Beardmore, A P; Boyd, P T; Cominsky, L; Gronwall, C; Fenimore, E E; Gehrels, N; Giommi, P; Goad, M; Hurley, K; Kennea, J A; Mason, K O; Marshall, F; Mészáros, P; Nousek, J A; Osborne, J P; Palmer, D M; Roming, P W A; Wells, A; White, N E; Zhang, B

    2005-01-01

    Gamma-ray Bursts (GRBs) are bright flashes of high energy photons that can last from about 10 milliseconds to 10 minutes. Their origin and nature have puzzled the scientific community for about 25 years until 1997, when the first X-ray afterglows of long (> 2 s duration) bursts were detected and the first optical and radio counterparts were found. These measurements established that long GRBs are typically at high redshift (z 1.6) and are in sub-luminous star-forming host galaxies. They are likely produced in core-collapse explosions of a class of massive stars that give rise to highly relativistic jets (collapsar model). Internal inhomogeneities in the velocity field of the relativistic expanding flow lead to collisions between fast moving and slow moving fluid shells and to the formation of internal shock waves. These shocks are believed to produce the observed prompt emission in the form of irregularly shaped and spaced pulses of gamma-rays, each pulse corresponding to a distinct internal collision. The ex...

  6. Case of huge neurofibroma expanding extra- and intracranially through the enlarged jugular foramen. CT scan findings and surgical approach

    Energy Technology Data Exchange (ETDEWEB)

    Hanakita, Junya; Imataka, Kiyoharu; Handa, Hajime (Kyoto Univ. (Japan). Faculty of Medicine)

    1984-01-01

    The surgical approach to the jugular foramen has been considered to be very difficult and troublesome, because of the location in which important structures, such as the internal jugular vein, internal carotid artery and lower cranial nerves, converge in the narrow deep space. A case of huge neurofibroma, which extended from the tentorium cerebelli through the dilated jugular foramen to the level of the vertebral body of C/sub 3/ was presented. A 12-year-old girl was admitted with complaints of visual disturbance and palsy of the V-XII cranial nerves of the left side. Plain skull film showed prominent widening of the cranial sutures and enlargement of the sella turcica. Horizontal CT scan with contrast showed symmetrical ventricular dilatation and a heterogeneously enhanced mass, which was situated mainly in the left CP angle. Coronal CT scan with contrast revealed a huge mass and enlarged jugular foramen, through which the tumor extended to the level of the vertebral body of C/sub 3/. Occlusion of the sigmoid sinus and the internal jugular vein of the left side was noticed in the vertebral angiography. Two-stage approach, the first one for removal of the intracranial tumor and the second one for extracranial tumor, was performed for its huge tumor. Several authors have reported excellent surgical approaches for the tumors situated in the jugular foramen. By our approach, modifying Gardner's original one, a wide operative field was obtained to remove the tumor around the jugular foramen with success. Our approach for the jugular foramen was described with illustrations.

  7. Scalable partitioning and exploration of chemical spaces using geometric hashing.

    Science.gov (United States)

    Dutta, Debojyoti; Guha, Rajarshi; Jurs, Peter C; Chen, Ting

    2006-01-01

    Virtual screening (VS) has become a preferred tool to augment high-throughput screening(1) and determine new leads in the drug discovery process. The core of a VS informatics pipeline includes several data mining algorithms that work on huge databases of chemical compounds containing millions of molecular structures and their associated data. Thus, scaling traditional applications such as classification, partitioning, and outlier detection for huge chemical data sets without a significant loss in accuracy is very important. In this paper, we introduce a data mining framework built on top of a recently developed fast approximate nearest-neighbor-finding algorithm(2) called locality-sensitive hashing (LSH) that can be used to mine huge chemical spaces in a scalable fashion using very modest computational resources. The core LSH algorithm hashes chemical descriptors so that points close to each other in the descriptor space are also close to each other in the hashed space. Using this data structure, one can perform approximate nearest-neighbor searches very quickly, in sublinear time. We validate the accuracy and performance of our framework on three real data sets of sizes ranging from 4337 to 249 071 molecules. Results indicate that the identification of nearest neighbors using the LSH algorithm is at least 2 orders of magnitude faster than the traditional k-nearest-neighbor method and is over 94% accurate for most query parameters. Furthermore, when viewed as a data-partitioning procedure, the LSH algorithm lends itself to easy parallelization of nearest-neighbor classification or regression. We also apply our framework to detect outlying (diverse) compounds in a given chemical space; this algorithm is extremely rapid in determining whether a compound is located in a sparse region of chemical space or not, and it is quite accurate when compared to results obtained using principal-component-analysis-based heuristics.

  8. Huge hepatocellular carcinoma with multiple intrahepatic metastases: An aggressive multimodal treatment

    Directory of Open Access Journals (Sweden)

    Satoshi Yasuda

    2015-01-01

    Conclusion: Multimodal treatment involving hepatectomy and TACE might be a good treatment strategy for patients with huge HCC with multiple intrahepatic metastases if the tumors are localized in the liver without distant or peritoneal metastasis.

  9. LSTM: A Search Space Odyssey

    OpenAIRE

    Greff, Klaus; Srivastava, Rupesh Kumar; Koutník, Jan; Steunebrink, Bas R.; Schmidhuber, Jürgen

    2015-01-01

    Several variants of the Long Short-Term Memory (LSTM) architecture for recurrent neural networks have been proposed since its inception in 1995. In recent years, these networks have become the state-of-the-art models for a variety of machine learning problems. This has led to a renewed interest in understanding the role and utility of various computational components of typical LSTM variants. In this paper, we present the first large-scale analysis of eight LSTM variants on three representati...

  10. On Building a Search Interface Discovery System

    Science.gov (United States)

    Shestakov, Denis

    A huge portion of the Web known as the deep Web is accessible via search interfaces to myriads of databases on the Web. While relatively good approaches for querying the contents of web databases have been recently proposed, one cannot fully utilize them having most search interfaces unlocated. Thus, the automatic recognition of search interfaces to online databases is crucial for any application accessing the deep Web. This paper describes the architecture of the I-Crawler, a system for finding and classifying search interfaces. The I-Crawler is intentionally designed to be used in the deep web characterization surveys and for constructing directories of deep web resources.

  11. A huge ovarian mucinous cystadenoma causing virilization, preterm labor, and persistent supine hypotensive syndrome during pregnancy.

    Science.gov (United States)

    Kucur, Suna Kabil; Acar, Canan; Temizkan, Osman; Ozagari, Aysim; Gozukara, Ilay; Akyol, Atif

    2016-01-01

    Mucinous cystadenoma (MC) of the ovary is an unilateral, multilocular cystic benign epithelial tumor. Supposed to be hormone responsive, MC reaches huge sizes during pregnancy. Aortocaval compression is common during pregnancy, especially when the pregnant woman is in the supine position. However, the compression recovers with a change in position. The authors report the first case of a huge mucinous cystadenoma of the ovary complicating pregnancy and causing virilization, premature labor, and persistent supine hypotensive syndrome.

  12. WIMPs search at OTO Cosmo Observatory

    Science.gov (United States)

    Fushimi, K.; Ichihara, K.; Koori, N.; Nakayama, S.; Shichijo, Y.; Ogawa, I.; Yoshida, S.; Ajimura, S.; Hazama, R.; Ishikawa, Y.; Itamura, M.; Kishimoto, T.; Kunitomi, G.; Matsuoka, K.; Miyawaki, H.; Shiomi, S.; Suzuki, N.; Tanaka, Y.; Umehara, S.; Ejiri, H.; Kudomi, N.; Kume, K.; Takahisa, K.; Ohsumi, H.; Yanagida, Y.

    2003-03-01

    WIMPs dark matter and double beta decays has been studied at OTO Cosmo Observatory. The observatory has great advantages of small cosmic ray flux, small neutron flux and small radon density. The recent status of WIMPs search by huge NaI (ELEGANT V), large CaF2Eu) (ELEGANT VI) and high sesitive NaI detector are reported.

  13. Indirect and inclusive search for dark matter with AMS02 space spectrometer; Recherche indirecte et inclusive de matiere noire avec le spectrometre spatial AMS02

    Energy Technology Data Exchange (ETDEWEB)

    Brun, P

    2007-06-15

    AMS02 is a particle physics detector designed for 3 years of data collecting aboard the International Space Station. Equipped with a superconducting magnet, it will allow to measure gamma and cosmic ray fluxes in the GeV to TeV region with high particle identification capabilities. Its performance is based on the redundancy of measurements in specific sub-detectors: a Time-Of-Flight counter, a Transition Radiation Detector, a Silicon Tracker, a Ring Imaging Cherenkov counter and an Electromagnetic calorimeter (Ecal). The Ecal is studied in details, in particular with the qualification of a stand-alone trigger devoted to gamma ray astronomy. This system allows the increase of the AMS02 sensitivity to photons, and the improvement of the reconstruction of electromagnetic events. The analog part of the trigger system has been tested with test benches and with a beam at CERN. The in-orbit calibration of the Ecal is studied, it may proceed in two steps. First, the Ecal cells responses have to be equalized with minimum ionizing particles data. Then an absolute calibration can be performed with cosmic electrons. For both the relative and the absolute calibration, possible procedures are defined and realistic calibration times are estimated. The second part deals with the indirect searches for dark matter and the study of the AMS02 sensitivity. Dark matter stands for 84% of the Universe mass and could consist in new particles. Dark matter particles are expected to surround our Galaxy and annihilate in high density regions. These annihilations could become observable exotic primary cosmic ray sources. Searches for anomalous excesses in (p-bar, e{sup +}, D-bar) and {gamma} ray fluxes will be performed by AMS02. A numerical tool allowing us to perform predictions for these exotic fluxes within supersymmetry or extra-dimension is developed and is presented in details. Phenomenological studies regarding possible enhancements of these signals by over-dense regions of the halo

  14. Indirect and inclusive search for dark matter with AMS02 space spectrometer; Recherche indirecte et inclusive de matiere noire avec le spectrometre spatial AMS02

    Energy Technology Data Exchange (ETDEWEB)

    Brun, Pierre [Laboratoire d' Annecy-le-vieux de Physique des Particules, Chemin de Bellevue, BP 110, 74941 Annecy-le-Vieux Cedex (France)

    2007-07-01

    AMS02 is a particle physics detector designed for 3 years of data taking aboard the International Space Station. Equipped with a superconducting magnet, it will allow to measure gamma and cosmic ray fluxes in the GeV to TeV region with high particle identification capabilities. Its performance is based on the redundancy of measurements in specific sub-detectors: a Time-Of-Flight counter, a Transition Radiation Detector, a Silicon Tracker, a Ring Imaging Cherenkov counter and an Electromagnetic calorimeter (Ecal). The Ecal is studied in details, in particular with the qualification of a stand-alone trigger devoted to gamma ray astronomy. This system allows to increase the AMS02 sensitivity to photons, and to improve the reconstruction of electromagnetic events. The analog part of the trigger system has been tested with test benches and in-beam at CERN. The in-orbit calibration of the Ecal is studied, it may proceed in two steps. First, the Ecal cells responses have to be equalized with minimum ionizing particles data. Then an absolute calibration can be performed with cosmic electrons. For both the relative and the absolute calibration, possible procedures are defined and realistic calibration times are estimated. The second part deals with the indirect searches for dark matter and the study of the AMS02 sensitivity. Dark matter stands for 84% of the Universe mass and could consist in new particles. Dark matter particles are expected to surround our Galaxy and annihilate in high density regions. These annihilations could become observable exotic primary cosmic ray sources. Searches for anomalous excesses in (p-bar, e{sup +}, D-bar) and {gamma} ray fluxes will be performed by AMS02. A numerical tool allowing to perform predictions for these exotic fluxes within supersymmetry or extra-dimension is developed and is presented in details. Phenomenological studies regarding possible enhancements of these signals by over-dense regions of the halo have also been performed

  15. Professional Microsoft search fast search, Sharepoint search, and search server

    CERN Document Server

    Bennett, Mark; Kehoe, Miles; Voskresenskaya, Natalya

    2010-01-01

    Use Microsoft's latest search-based technology-FAST search-to plan, customize, and deploy your search solutionFAST is Microsoft's latest intelligent search-based technology that boasts robustness and an ability to integrate business intelligence with Search. This in-depth guide provides you with advanced coverage on FAST search and shows you how to use it to plan, customize, and deploy your search solution, with an emphasis on SharePoint 2010 and Internet-based search solutions.With a particular appeal for anyone responsible for implementing and managing enterprise search, this book presents t

  16. The HUGE formula (hematocrit, urea and gender): association with cardiovascular risk.

    Science.gov (United States)

    Robles, N R; Felix, F J; Fernandez-Berges, D; Perez-Castán, J; Zaro, M J; Lozano, L; Alvarez-Palacios, P; Garcia-Trigo, A; Tejero, V; Morcillo, Y; Hidalgo, A B

    2013-07-01

    To evaluate the relationship between chronic renal failure (CFR) defined through HUGE (hematocrit, urea and gender) formula score and the patient's cardiovascular risk measured through cardiovascular disease antecedents such as ischemic cardiopathy, cerebrovascular disease and peripheral arterial disease. The sample consisted of 2,831 subjects. Mean age was 51.2±14.7 years and 53.5% were female. Serum creatinine, urea, hematocrit and 24h proteinuria were analyzed. HUGE score was calculated from gender, urea and hematocrit. GFR was estimated from uncalibrated serum creatinine using the abbreviated Modification of Diet in Renal Disease equation (MDRD-4). UAE was measured in first morning urine sample. Using HUGE formula 2.2% (n = 61) of subjects had CRF. Of them, 12 (19.7%) had cardiovascular disease history. Among patients without CRF (n = 2770), 194 subjects had history of previous cardiovascular diseases (0.07%; p HUGE definition of CRF was 3.25 (p = 0.001, Mantel-Haenszel test). CFR was associated to higher pulse pressure (PP) and increased urinary albumin excretion. A significant cardiovascular risk was associated to the diagnosis of CRF through HUGE formula. This relation was closer than the obtained using MDRD estimated GFR in spite of a bigger sample. HUGE formula seems to be a useful tool for diagnosing CRF and evaluate the cardiovascular risk of these patients.

  17. The quest for complex molecules in space: Laboratory spectroscopy of n-butyl cyanide, n-C4H9CN, in the millimeter wave region and its astronomical search in Sagittarius B2(N)

    OpenAIRE

    Ordu, M. H.; Müller, H. S. P.; Walters, A.; Nuñez, M; Lewen, F.; Belloche, A.; Menten, K. M.; Schlemmer, S.

    2012-01-01

    The saturated n-propyl cyanide was recently detected in Sagittarius B2(N). The next larger unbranched alkyl cyanide is n-butyl cyanide. We provide accurate rest frequency predictions beyond the millimeter wave range to search for this molecule in the Galactic center source Sagittarius B2(N) and facilitate its detection in space. We investigated the laboratory rotational spectrum of $n$-butyl cyanide between 75 GHz and 348 GHz. We searched for emission lines produced by the molecule in our sen...

  18. Tag Based Audio Search Engine

    Directory of Open Access Journals (Sweden)

    Parameswaran Vellachu

    2012-03-01

    Full Text Available The volume of the music database is increasing day by day. Getting the required song as per the choice of the listener is a big challenge. Hence, it is really hard to manage this huge quantity, in terms of searching, filtering, through the music database. It is surprising to see that the audio and music industry still rely on very simplistic metadata to describe music files. However, while searching audio resource, an efficient "Tag Based Audio Search Engine" is necessary. The current research focuses on two aspects of the musical databases 1. Tag Based Semantic Annotation Generation using the tag based approach.2. An audio search engine, using which the user can retrieve the songs based on the users choice. The proposed method can be used to annotation and retrieve songs based on musical instruments used , mood of the song, theme of the song, singer, music director, artist, film director, instrument, genre or style and so on.

  19. Search Cloud

    Science.gov (United States)

    ... of this page: https://medlineplus.gov/cloud.html Search Cloud To use the sharing features on this ... of Top 110 zoster vaccine Share the MedlinePlus search cloud with your users by embedding our search ...

  20. Structure determination of symmetric homo-oligomers by a complete search of symmetry configuration space, using NMR restraints and van der Waals packing.

    Science.gov (United States)

    Potluri, Shobha; Yan, Anthony K; Chou, James J; Donald, Bruce R; Bailey-Kellogg, Chris

    2006-10-01

    Structural studies of symmetric homo-oligomers provide mechanistic insights into their roles in essential biological processes, including cell signaling and cellular regulation. This paper presents a novel algorithm for homo-oligomeric structure determination, given the subunit structure, that is both complete, in that it evaluates all possible conformations, and data-driven, in that it evaluates conformations separately for consistency with experimental data and for quality of packing. Completeness ensures that the algorithm does not miss the native conformation, and being data-driven enables it to assess the structural precision possible from data alone. Our algorithm performs a branch-and-bound search in the symmetry configuration space, the space of symmetry axis parameters (positions and orientations) defining all possible C(n) homo-oligomeric complexes for a given subunit structure. It eliminates those symmetry axes inconsistent with intersubunit nuclear Overhauser effect (NOE) distance restraints and then identifies conformations representing any consistent, well-packed structure to within a user-defined similarity level. For the human phospholamban pentamer in dodecylphosphocholine micelles, using the structure of one subunit determined from a subset of the experimental NMR data, our algorithm identifies a diverse set of complex structures consistent with the nine intersubunit NOE restraints. The distribution of determined structures provides an objective characterization of structural uncertainty: backbone RMSD to the previously determined structure ranges from 1.07 to 8.85 A, and variance in backbone atomic coordinates is an average of 12.32 A(2). Incorporating vdW packing reduces structural diversity to a maximum backbone RMSD of 6.24 A and an average backbone variance of 6.80 A(2). By comparing data consistency and packing quality under different assumptions of oligomeric number, our algorithm identifies the pentamer as the most likely oligomeric state

  1. Adaptive Large Neighbourhood Search

    DEFF Research Database (Denmark)

    Røpke, Stefan

    Large neighborhood search is a metaheuristic that has gained popularity in recent years. The heuristic repeatedly moves from solution to solution by first partially destroying the solution and then repairing it. The best solution observed during this search is presented as the final solution....... This tutorial introduces the large neighborhood search metaheuristic and the variant adaptive large neighborhood search that dynamically tunes parameters of the heuristic while it is running. Both heuristics belong to a broader class of heuristics that are searching a solution space using very large...... neighborhoods. The tutorial also present applications of the adaptive large neighborhood search, mostly related to vehicle routing problems for which the heuristic has been extremely successful. We discuss how the heuristic can be parallelized and thereby take advantage of modern desktop computers...

  2. Construction of customized sub-databases from NCBI-nr database for rapid annotation of huge metagenomic datasets using a combined BLAST and MEGAN approach

    OpenAIRE

    2013-01-01

    We developed a fast method to construct local sub-databases from the NCBI-nr database for the quick similarity search and annotation of huge metagenomic datasets based on BLAST-MEGAN approach. A three-step sub-database annotation pipeline (SAP) was further proposed to conduct the annotation in a much more time-efficient way which required far less computational capacity than the direct NCBI-nr database BLAST-MEGAN approach. The 1(st) BLAST of SAP was conducted using the original metagenomic d...

  3. Newtonian self-gravitating system in a relativistic huge void universe model

    Science.gov (United States)

    Nishikawa, Ryusuke; Nakao, Ken-ichi; Yoo, Chul-Moon

    2016-12-01

    We consider a test of the Copernican Principle through observations of the large-scale structures, and for this purpose we study the self-gravitating system in a relativistic huge void universe model which does not invoke the Copernican Principle. If we focus on the the weakly self-gravitating and slowly evolving system whose spatial extent is much smaller than the scale of the cosmological horizon in the homogeneous and isotropic background universe model, the cosmological Newtonian approximation is available. Also in the huge void universe model, the same kind of approximation as the cosmological Newtonian approximation is available for the analysis of the perturbations contained in a region whose spatial size is much smaller than the scale of the huge void: the effects of the huge void are taken into account in a perturbative manner by using the Fermi-normal coordinates. By using this approximation, we derive the equations of motion for the weakly self-gravitating perturbations whose elements have relative velocities much smaller than the speed of light, and show the derived equations can be significantly different from those in the homogeneous and isotropic universe model, due to the anisotropic volume expansion in the huge void. We linearize the derived equations of motion and solve them. The solutions show that the behaviors of linear density perturbations are very different from those in the homogeneous and isotropic universe model.

  4. Search Recipes

    Science.gov (United States)

    ... Tips A to Z Map Search Enter your search term 98 results • Advanced Search Everything News Videos e- ... usda.gov https://www.whatscooking.fns.usda.gov/search/solr-results/im_field_term_program/child-nutrition-cnp-163 We would like ...

  5. 反潜机采用阿基米德螺旋线搜潜问题研究%Track Spacing for an Archimedes Spiral Search by a Maritime Patrol Aircraft (MPA) in Anti-submarine Warfare (ASW) Operations

    Institute of Scientific and Technical Information of China (English)

    李海敏

    2014-01-01

    The ASW capabilities is very important.In this paper,according to the situation of the ASW, the recommended track spacing for an Archimedes spiral search in a datum search problem is studied. To find a recommended track spacing, three analytical approaches are explored. To find the best⁃fit parameters maximizing probability of detection and the best track interval, a simulation experiment with a NOLH ( Nearly Orthogonal Latin Hypercube) design is used, in order to provide tactical reference for the recommended track spacing for an Archimedes spiral search.%反潜机是重要的反潜力量,根据反潜机搜潜情况,建立了反潜飞机采用阿基米德螺旋线样式搜潜的数学模型和目标运动模型,讨论了螺旋线采用的三种轨迹间隔,通过仿真验证,确立了反潜机搜潜最优轨迹间隔,以达到提高发现目标潜艇概率、优化反潜效能的目的,为反潜飞机采用阿基米德巡逻线搜潜样式搜潜时提供战术参考。

  6. Search Patterns

    CERN Document Server

    Morville, Peter

    2010-01-01

    What people are saying about Search Patterns "Search Patterns is a delight to read -- very thoughtful and thought provoking. It's the most comprehensive survey of designing effective search experiences I've seen." --Irene Au, Director of User Experience, Google "I love this book! Thanks to Peter and Jeffery, I now know that search (yes, boring old yucky who cares search) is one of the coolest ways around of looking at the world." --Dan Roam, author, The Back of the Napkin (Portfolio Hardcover) "Search Patterns is a playful guide to the practical concerns of search interface design. It cont

  7. Colonic Angiodysplasia with a Huge Submucosal Hematoma in the Sigmoid Colon.

    Science.gov (United States)

    Shimizu, Takayuki; Koike, Daisuke; Nomura, Yukihiro; Ooe, Kenji

    2016-01-01

    Colonic angiodysplasia (AD) with bleeding as a comorbidity in the aging population is being increasingly reported. However, to our knowledge, there is no report on colonic AD accompanied by a huge hematoma. Herein, we report a case of colonic AD with a huge submucosal hematoma. A 75-year-old man with sudden melena was referred to our hospital. Helical computed tomographic angiography (CTA) revealed bleeding from the sigmoid colon. Additionally, colonoscopy showed a huge submucosal hematoma with bleeding in the sigmoid colon. As endoscopic hemostasis was difficult, sigmoidectomy was performed. The pathological diagnosis was colonic AD. The present case indicates that colonic AD should be considered in the differential diagnosis for melena. In addition, the case shows that helical CTA, which is a noninvasive imaging modality, is useful for the diagnosis of colonic AD and is as effective as colonoscopy and angiography for diagnosis.

  8. Giant pulmonary teratoma with huge splenic lymphangiomatosis: a very rare case.

    Science.gov (United States)

    Alsubaie, Hemail M; Alsubaie, Khaled M; Mahfouz, Mohammed Eid

    2017-09-01

    Teratomas are tumors composed of tissues derived from more than one germ cell line. They manifested with a great variety of clinical and radiological features. We report a case of a giant left hemithorax teratoma in a female with huge spleen tumor and review the relevant literature. A 38-year-old female with progressively aggravating dyspnea at rest from a mild trauma. Absent breath sounds on the left side. There was splenomegaly. Computed tomography scan revealed a huge mass (20 × 15 × 18 cm), containing elements of heterogeneous density in the left hemithorax. The spleen tumor was occupying most of the spleen without any other abdominal manifestations. The patient underwent left thoracotomy and laparoscopic splenectomy. Histopathological examination revealed a benign mature teratoma and cystic lymphangiomatosis of the spleen. To the best of our knowledge and after reviewing the available literature this is the first case of huge mature pulmonary teratoma with large cystic spleen lymphangiomatosis.

  9. Huge splenic epidermoid cyst with elevation of serum CA19-9 level.

    Science.gov (United States)

    Matsumoto, Sayo; Mori, Toshifumi; Miyoshi, Jinsei; Imoto, Yoshitaka; Shinomiya, Hirohiko; Wada, Satoshi; Nakao, Toshihiro; Shinohara, Hisamitsu; Yoshida, Sadahiro; Izumi, Keisuke; Okazaki, Jun; Muguruma, Naoki; Takayama, Tetsuji

    2015-01-01

    A 30-year-old female was referred to our hospital for further examination of liver dysfunction. A huge, soft mass was noted in her left upper quadrant on physical examination. Abdominal ultrasonography and computed tomography revealed a huge cystic tumor of 20 cm in the hilus of the spleen. Serum CA19-9 was 491 U/ml, and splenectomy was performed under suspicion of a malignant cystic tumor. The inner surface of the cyst was lined by squamous epithelial cells that were immunohistochemically positive for CA19-9. Serum CA19-9 level was normalized after the surgery. Our case of a very rare, huge epidermoid cyst of the spleen suggests that measurement of the serum CA19-9 level is useful for evaluating therapeutic efficacy of a splenic epidermoid cyst.

  10. Endovascular Treatment of a Huge Hepatic Artery Aneurysm by Coil Embolization Method: A Case Report.

    Science.gov (United States)

    Hemmati, Hossein; Karimian, Mehdi; Moradi, Habibollah; Farid Marandi, Kambiz; Haghdoost, Afrooz

    2015-07-01

    Hepatic artery aneurysms are rare but potentially life threatening. We describe a novel case of a successful endovascular coil embolization of a huge hepatic artery aneurysm. A 67-year-old woman presented with recent abdominal pain that had begun from 2 weeks before referring to our hospital. Sonographic and computerized tomographic (CT) findings revealed a huge hepatic artery aneurysm with 95 mm × 83 mm diameter. The patient underwent an endovascular technique. In aortic angiography, the celiac artery orifice and superior mesenteric artery were so narrow, so sonography was used in order to determine the exact position of the catheter in the celiac artery orifice. The aneurysm was thrombosed using coil embolization. Pulsation of the aneurysm immediately disappeared. Huge hepatic artery aneurysm can be safely treated using coil embolization.

  11. Collaborative treatment of huge intrathoracic meningoceles associated with neurofibromatosis type 1: a case report.

    Science.gov (United States)

    Cho, Deog Gon; Chang, Yong Jin; Cho, Kyu Do; Hong, Jae Taek

    2015-11-10

    An intrathoracic meningocele is a relatively rare disease, and it commonly accompanies neurofibromatosis type 1. Patients tend to have no symptom but if its size is too large and compresses a lung and neighboring organs, it needs shunt drainage or surgical resection. Herein, we present the case of a 52 year-old female patient with huge intrathoracic meningoceles associated with neurofibromatosis type 1, who has complained about chest discomfort and dyspnea at rest. As for a preliminary treatment, a neurosurgeon had performed a cystoperitoneal shunt, but the symptoms continued and the size of mass and the amount of pleural effusion did not change significantly. Therefore, the huge thoracic meningoceles were successfully treated through the thoracotomic approach in combination with lumbar puncture and cerebrospinal fluid drainage. It is reported that double huge intrathoracic meningoceles associated with neurofibromatosis type 1 was successfully treated by a shunting procedure followed by thoracotomic resection with collaboration of a neurosurgeon.

  12. ArraySearch: A Web-Based Genomic Search Engine.

    Science.gov (United States)

    Wilson, Tyler J; Ge, Steven X

    2012-01-01

    Recent advances in microarray technologies have resulted in a flood of genomics data. This large body of accumulated data could be used as a knowledge base to help researchers interpret new experimental data. ArraySearch finds statistical correlations between newly observed gene expression profiles and the huge source of well-characterized expression signatures deposited in the public domain. A search query of a list of genes will return experiments on which the genes are significantly up- or downregulated collectively. Searches can also be conducted using gene expression signatures from new experiments. This resource will empower biological researchers with a statistical method to explore expression data from their own research by comparing it with expression signatures from a large public archive.

  13. Huge Bilateral Paramesonephric Cysts in a 25 year old Nulliparous woman

    Science.gov (United States)

    Sagili, Haritha; Krishnan, Manikandan; Dasari, Papa

    2013-01-01

    Paraovarian cysts are uncommon adnexal masses which are usually asymptomatic. We describe a case of bilateral huge paramesonephric cysts in a nulliparous woman. A 25-year-old lady presented with abdominal distension for one year duration. Examination and imaging revealed large abdominopelvic cystic masses with no solid areas or septations. Intraoperatively there were huge bilateral paraovarian cysts which were excised. Histopathology revealed low cuboidal to ciliated columnar epithelium with no evidence of ovarian parenchyma suggestive of paramesonephric cyst. Paraovarian cyst should be included in the differential diagnosis of a cystic mass visualised on ultrasound. PMID:24392412

  14. Huge dissected ascending aorta associated with pseudo aneurysm and aortic coarctation feridoun.

    Science.gov (United States)

    Sabzi, Feridoun; Khosravi, Donya

    2015-07-01

    We report a unique case of chronic dissection of the ascending aorta complicated with huge and thrombotic pseudoaneurysm in a patient with coarctation of descending aorta. Preoperative investigations such as transesophageal echocardiography (TEE) confirmed the diagnosis of dissection. Intraoperative findings included a12 cm eccentric bulge of the right lateral side of dilated the ascending aorta filled with the clot and a circular shaped intimal tear communicating with an extended hematoma and dissection of the media layer. The rarity of the report is an association of the chronic dissection with huge pseudoaneurysm and coarctation. The patient underwent staged repair of an aneurysm and coarctation and had an uneventful postoperative recovery period.

  15. Object searching and operation of service robots in intelligent space%智能空间中的服务机器人物品搜寻与操作

    Institute of Scientific and Technical Information of China (English)

    薛英花; 田国会; 周风余; 李国栋; 尹建芹

    2012-01-01

    为了实现服务机器人在智能空间中以人为中心的主动服务,提出一个实现机器人在室内复杂环境中的物品搜寻与操作的完整的方案.该方案首先根据建立的射频识别(RFID)定向天线识别范围概率模型,利用Bayes规则实现RFID物品粗定位.然后运用设计的基于人工物标的多种类物品识别方法,并利用建立的机器人系统模型和获取的物品特征,实现快速高效的单目视觉定位.最后用设计的眼注视约束下的基于位置的视觉伺服系统,实现物品的抓取和运送等操作.基于此方案,设计并实现了一个服务机器人物品搜寻与操作系统,该系统既充分发挥了RFID在大范围远距离物品搜寻的优势,又有效利用了本体视觉提供的丰富信息,能准确识别室内多种类物品,定位精度高,稳定性好,并可在一定程度上解决遮挡问题.目前,该系统已成功地应用到智能空间的主动服务中,运行良好.%In this paper, complete object searching and operating scheme for a service robot in complex indoor environments is presented to realize its human-centered active service in an intelligent space. The scheme is described as below. Firstly, the rough localization for an object is realized using the probability model for radio frequency identification (RFID) antenna's recognition scope and the Bayes Rule. Then, with the aid of an artificial object mark based recognition approach for multi-type objects, the quick and efficient localization based on monocular vision is realized using the system model of robot and the object' s features. Finally, a position based visual servoing control law under eye-gaze constraint is used to realize object grasp and delivery. An object rearching and operating system was designed and implemented according the scheme. The system not only makes full use of the advantages of RFID in the field of object localization in a large scale, but also efficiently utilizes the rich

  16. Space space space

    CERN Document Server

    Trembach, Vera

    2014-01-01

    Space is an introduction to the mysteries of the Universe. Included are Task Cards for independent learning, Journal Word Cards for creative writing, and Hands-On Activities for reinforcing skills in Math and Language Arts. Space is a perfect introduction to further research of the Solar System.

  17. Endovascular repair for a huge vertebral artery pseudoaneurysm caused by Behcet's disease

    Institute of Scientific and Technical Information of China (English)

    DONG Zhi-hui; FU Wei-guo; GUO Da-qiao; XU Xin; CHEN Bin; JIANG Jun-hao; YANG Jue; SHI Zheng-yu; WANG Yu-qi

    2006-01-01

    @@ Behcet's disease (BD), a multisystem chronic autoimmune process of unknown etiology,usually leads to arterial impairment. Isolated case reports have described BD-related arterial dissections, pseudoaneurysms or aneurysms.1-4 Recently, we successfully treated a huge vertebral artery pseudoaneurysm (VAPA) in a patient with BD by stent-grafting with preservation of the affected vertebral artery.

  18. Unusual Huge Keratoacanthoma in Sites of in the Previous Split-Thickness Skin Grafted Area

    Directory of Open Access Journals (Sweden)

    Fatih Uygur

    2009-09-01

    Full Text Available Keratoacanthoma (KA is a fairly common keratinizing, squamous neoplasm. The exact etiology of KA is unknown. However, ultraviolet radiation, trauma, chemical carcinogens, viral infections, immunosuppression, genetic factors, radiation and thermal burns have been accused of pathogenesis. In here, we represent an unusual huge KA arising from the previous reconstructed with split-thickness skin graft on the dorsal foot.

  19. Constructing Optimal Coarse-Grained Sites of Huge Biomolecules by Fluctuation Maximization.

    Science.gov (United States)

    Li, Min; Zhang, John Zenghui; Xia, Fei

    2016-04-12

    Coarse-grained (CG) models are valuable tools for the study of functions of large biomolecules on large length and time scales. The definition of CG representations for huge biomolecules is always a formidable challenge. In this work, we propose a new method called fluctuation maximization coarse-graining (FM-CG) to construct the CG sites of biomolecules. The defined residual in FM-CG converges to a maximal value as the number of CG sites increases, allowing an optimal CG model to be rigorously defined on the basis of the maximum. More importantly, we developed a robust algorithm called stepwise local iterative optimization (SLIO) to accelerate the process of coarse-graining large biomolecules. By means of the efficient SLIO algorithm, the computational cost of coarse-graining large biomolecules is reduced to within the time scale of seconds, which is far lower than that of conventional simulated annealing. The coarse-graining of two huge systems, chaperonin GroEL and lengsin, indicates that our new methods can coarse-grain huge biomolecular systems with up to 10,000 residues within the time scale of minutes. The further parametrization of CG sites derived from FM-CG allows us to construct the corresponding CG models for studies of the functions of huge biomolecular systems.

  20. Anatomic trisegmentectomy: An alternative treatment for huge or multiple hepatocellular carcinoma of right liver.

    Science.gov (United States)

    Jia, Changku; Weng, Jie; Qin, Qifan; Chen, Youke; Huang, Xiaolong; Fu, Yu

    2017-04-01

    The patients with huge (≥10cm) or multiple hepatocellular carcinoma (HCC) in the right liver and insufficient size of the remnant left liver can not be performed an operation of right hemihepatectomy because of that liver failure will occur post operation. We designed anatomic trisegmentectomy in right liver to increase the ratio of future liver remnant volume (%FLRV), thus increasing resectability of huge or multiple HCC. Thirteen patients were analyzed by preoperative CT scan for liver and tumor volumetries. If the right hemihepatectomy was done, %FLRV would be at the range of 29.6%-37.5%. However, if trisegmentectomy was done, %FLRV would increase by an average of 14.0%. So patients will not undergo postoperative liver failure due to sufficient %FLRV. Therefore, we designed anatomic trisegmentectomy, with retention of segment 5 or segment 8, to increase %FLRV and increase the resectability for huge or multiple HCC. After trisegmentectomy, the inflow and outflow of remnant liver were maintained well. Severe complications and mortality were not happened post operation. Of the 13 patients, 10 survived up to now. Of the 10 living cases, postoperative lung metastasis was found in 2 and intrahepatic recurrence was found in 1. These 3 patients survive with tumor after comprehensive therapies including oral administration of Sorafenib. Compared to right hemihepatectomy, anatomic trisegmentectomy in right liver guarantees the maximum preservation of %FLRV to increase the resectability of huge or multiple HCC, thus improving the overall resection rate. Copyright © 2017. Published by Elsevier Masson SAS.

  1. Huge hepatocellular carcinoma with multiple intrahepatic metastases: An aggressive multimodal treatment.

    Science.gov (United States)

    Yasuda, Satoshi; Nomi, Takeo; Hokuto, Daisuke; Yamato, Ichiro; Obara, Shinsaku; Yamada, Takatsugu; Kanehiro, Hiromichi; Nakajima, Yoshiyuki

    2015-01-01

    Huge hepatocellular carcinoma (HCC) possesses a potential risk for spontaneous rupture, which leads to a life-threatening complication with a high mortality rate. In addition, a large HCC is frequently accompanied by intrahepatic metastases. We describe, the case of a 74-year-old woman with a huge extrahepatically expanding HCC with multiple intrahepatic metastases who was treated by liver resection with repeated transcatheter arterial chemoembolization (TACE). To prevent tumor rupture or bleeding, we performed right hepatectomy. After the operation, TACE was applied for multiple intrahepatic metastases in the remnant liver. Furthermore, the elevated protein induced vitamin K absence (PIVKA II) level had decreased to limits within the normal range. Three months after the first TACE, computed tomography revealed several recurrences in the liver. TACE was applied for the second and third time and the tumors were well controlled. Although, liver resection is occasionally performed for patients with huge HCC to avoid spontaneous tumor rupture, only surgical approach might not be sufficient for such advanced HCC. To achieve long-term survival, it is necessary to control the residual intrahepatic tumors. We could control multiple intrahepatic metastases with repeated TACEs after hepatectomy. Multimodal treatment involving hepatectomy and TACE might be a good treatment strategy for patients with huge HCC with multiple intrahepatic metastases if the tumors are localized in the liver without distant or peritoneal metastasis. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. Hepatic arterial infusion chemotherapy for patients with huge unresectable hepatocellular carcinoma.

    Science.gov (United States)

    Tsai, Wei-Lun; Lai, Kwok-Hung; Liang, Huei-Lung; Hsu, Ping-I; Chan, Hoi-Hung; Chen, Wen-Chi; Yu, Hsien-Chung; Tsay, Feng-Woei; Wang, Huay-Min; Tsai, Hung-Chih; Cheng, Jin-Shiung

    2014-01-01

    The optimal treatment for huge unresectable hepatocellular carcinoma (HCC) remains controversial. The outcome of transcatheter arterial chemoembolization (TACE) for patients huge unresectable HCC is generally poor and the survival benefit of TACE in these patients is unclear. The aim of the study is to compare the effect of hepatic arterial infusion chemotherapy (HAIC) versus symptomatic treatment in patients with huge unresectable HCC. Since 2000 to 2005, patients with huge (size >8 cm) unresectable HCC were enrolled. Fifty-eight patients received HAIC and 44 patients received symptomatic treatment. In the HAIC group, each patient received 2.4+1.4 (range: 1-6) courses of HAIC. Baseline characteristics and survival were compared between the HAIC and symptomatic treatment groups. The HAIC group and the symptomatic treatment group were similar in baseline characteristics and tumor stages. The overall survival rates at one and two years were 29% and 14% in the HAIC group and 7% and 5% in the symptomatic treatment group, respectively. The patients in the HAIC group had significantly better overall survival than the symptomatic treatment group (Phuge unresectable HCC.

  3. A Computational Method for Enabling Teaching-Learning Process in Huge Online Courses and Communities

    Science.gov (United States)

    Mora, Higinio; Ferrández, Antonio; Gil, David; Peral, Jesús

    2017-01-01

    Massive Open Online Courses and e-learning represent the future of the teaching-learning processes through the development of Information and Communication Technologies. They are the response to the new education needs of society. However, this future also presents many challenges such as the processing of online forums when a huge number of…

  4. A Huge Subcutaneous Hematoma in an Adult with Kasabach-Merritt Syndrome.

    Science.gov (United States)

    Wu, Kuan-Lin; Liao, Chiung-Ying; Chang, Chen-Kuang; Ho, Shang-Yun; Tyan, Yeu-Sheng; Huang, Yuan-Chun

    2017-06-19

    BACKGROUND Kasabach-Merritt syndrome is a potentially fatal disease that consists of hemangioma(s) with thrombocytopenia, microangiopathic hemolytic anemia, and coagulopathy. Extensive hemangiomatosis is rare. We present the radiological features and treatment strategy of a young adult suffering from Kasabach-Merritt syndrome with widespread hemangiomas and an infected huge hematoma in the right thigh. CASE REPORT A 33-year-old Taiwanese male presented with a painful 20-cm mass over his right thigh and gross hematuria for 2 days. Hemangiomatosis was bioptically proven in infancy and the patient was under regular follow-up. Physical examination revealed normal heart rate, respiratory rate, and body temperature. Multiple palpable lumps with brown and purple areas of skin over the neck, trunk, and right thigh were noted. Laboratory examinations revealed thrombocytopenia anemia and elevated fibrin degradation products. There were no signs of sepsis. Blood transfusion and steroid therapy were executed. Computed tomography showed a huge complicated subcutaneous hematoma in the right thigh. Drainage of the huge hematoma was performed and antibiotics were prescribed. After the local infection in the right thigh and the bleeding tendency were controlled, the patient was discharged in a stable condition two weeks later. CONCLUSIONS A huge infected hematoma and widespread hemangiomas are extremely rare complications of Kasabach-Merritt syndrome. There are no known treatment guidelines currently available. Our patient was successfully treated with steroids, drainage, and antibiotics.

  5. A Huge Ovarian Cyst in a Middle-Aged Iranian Female

    Directory of Open Access Journals (Sweden)

    Mohammad Kazem Moslemi

    2010-05-01

    Full Text Available A 38-year-old Iranian woman was found to have a huge ovarian cystic mass. Her presenting symptom was vague abdominal pain and severe abdominal distention. She underwent laparotomy and after surgical removal, the mass was found to be mucinous cystadenoma on histology.

  6. Huge right atrial myxoma causing fixed tricuspid stenosis with constitutional symptoms.

    Science.gov (United States)

    Kuralay, Erkan; Cingöz, Faruk; Günay, Celalettin; Demirkiliç, Ufuk; Tatar, Harun

    2003-01-01

    Nonspecific constitutional symptoms are reported mostly in patients with left-atrial myxomas, which occur five times as often as its right-atrial counterpart. We present huge right-atrial myxoma, which obstructs tricuspid orifice with nonspecific constitutional symptoms without any pulmonary embolism attack.

  7. Preserving stability of huge agriculture machines with internal mobilities: Application to a grape harvester

    OpenAIRE

    Dieumet, D.; Thuilot, B.; Lenain, R.; Berducat, M.

    2012-01-01

    International audience; This paper proposes an algorithm for estimating on-line the rollover risk of huge machine moving on natural ground. The approach is based on the reconstruction of lateral load transfer thanks to an observer, able to take into account terrain specificities (grip conditions and geometry). Capabilities are tested through experiments on a grape harvester.

  8. Enhancements to Constrained Novelty Search: Two-Population Novelty Search for Generating Game Content

    DEFF Research Database (Denmark)

    Liapis, Antonios; Yannakakis, Georgios N.; Togelius, Julian

    2013-01-01

    Novelty search is a recent algorithm geared to explore search spaces without regard to objectives; minimal criteria novelty search is a variant of this algorithm for constrained search spaces. For large search spaces with multiple constraints, however, it is hard to find a set of feasible...... individuals that is both large and diverse. In this paper, we present two new methods of novelty search for constrained spaces, Feasible-Infeasible Novelty Search and Feasible-Infeasible Dual Novelty Search. Both algorithms keep separate populations of feasible and infeasible individuals, inspired by the FI-2...... diverse sets of feasible strategy game maps than existing algorithms. However, the best algorithm is contingent on the particularities of the search space and the genetic operators used. It is also shown that the proposed enhancement of offspring boosting increases performance in all cases....

  9. Construction of customized sub-databases from NCBI-nr database for rapid annotation of huge metagenomic datasets using a combined BLAST and MEGAN approach.

    Science.gov (United States)

    Yu, Ke; Zhang, Tong

    2013-01-01

    We developed a fast method to construct local sub-databases from the NCBI-nr database for the quick similarity search and annotation of huge metagenomic datasets based on BLAST-MEGAN approach. A three-step sub-database annotation pipeline (SAP) was further proposed to conduct the annotation in a much more time-efficient way which required far less computational capacity than the direct NCBI-nr database BLAST-MEGAN approach. The 1(st) BLAST of SAP was conducted using the original metagenomic dataset against the constructed sub-database for a quick screening of candidate target sequences. Then, the candidate target sequences identified in the 1(st) BLAST were subjected to the 2(nd) BLAST against the whole NCBI-nr database. The BLAST results were finally annotated using MEGAN to filter out those mistakenly selected sequences in the 1(st) BLAST to guarantee the accuracy of the results. Based on the tests conducted in this study, SAP achieved a speedup of ~150-385 times at the BLAST e-value of 1e-5, compared to the direct BLAST against NCBI-nr database. The annotation results of SAP are exactly in agreement with those of the direct NCBI-nr database BLAST-MEGAN approach, which is very time-consuming and computationally intensive. Selecting rigorous thresholds (e.g. e-value of 1e-10) would further accelerate SAP process. The SAP pipeline may also be coupled with novel similarity search tools (e.g. RAPsearch) other than BLAST to achieve even faster annotation of huge metagenomic datasets. Above all, this sub-database construction method and SAP pipeline provides a new time-efficient and convenient annotation similarity search strategy for laboratories without access to high performance computing facilities. SAP also offers a solution to high performance computing facilities for the processing of more similarity search tasks.

  10. Personalized Search

    CERN Document Server

    AUTHOR|(SzGeCERN)749939

    2015-01-01

    As the volume of electronically available information grows, relevant items become harder to find. This work presents an approach to personalizing search results in scientific publication databases. This work focuses on re-ranking search results from existing search engines like Solr or ElasticSearch. This work also includes the development of Obelix, a new recommendation system used to re-rank search results. The project was proposed and performed at CERN, using the scientific publications available on the CERN Document Server (CDS). This work experiments with re-ranking using offline and online evaluation of users and documents in CDS. The experiments conclude that the personalized search result outperform both latest first and word similarity in terms of click position in the search result for global search in CDS.

  11. Search Combinators

    CERN Document Server

    Schrijvers, Tom; Wuille, Pieter; Samulowitz, Horst; Stuckey, Peter J

    2012-01-01

    The ability to model search in a constraint solver can be an essential asset for solving combinatorial problems. However, existing infrastructure for defining search heuristics is often inadequate. Either modeling capabilities are extremely limited or users are faced with a general-purpose programming language whose features are not tailored towards writing search heuristics. As a result, major improvements in performance may remain unexplored. This article introduces search combinators, a lightweight and solver-independent method that bridges the gap between a conceptually simple modeling language for search (high-level, functional and naturally compositional) and an efficient implementation (low-level, imperative and highly non-modular). By allowing the user to define application-tailored search strategies from a small set of primitives, search combinators effectively provide a rich domain-specific language (DSL) for modeling search to the user. Remarkably, this DSL comes at a low implementation cost to the...

  12. Relation Inclusive Search for Hindi Documents

    Directory of Open Access Journals (Sweden)

    Pooja Arora

    2013-08-01

    Full Text Available Information retrieval (IR techniques become a challenge to researchers due to huge growth of digital and information retrieval. As a wide variety of Hindi Data and Literature is now available on web, we have developed information retrieval system for Hindi documents. This paper presents a new searching technique that has promising results in terms of F-measure. Historically, there have been two major approaches to IR - keyword based search and concept based search. We have introduced new relation inclusive search which performs searching of documents using case role relation, spatial relation and temporal relation of query terms and gives results better than previously used approaches. In this method we have used new indexing technique which stores information about relation between terms along with its position. We have compared four types of searching: Keyword Based search without Relation Inclusive, Keyword Based search with Relation Inclusive, Concept Based search without Relation Inclusive and Concept Based search with Relation Inclusive. Our proposed searching method gave significant improvement in terms of F-measure. For experiments we have used Hindi document corpus, Gyannidhi from C-DAC. This technique effectively improves search performance for documents in English as well.

  13. Biliary obstruction due to a huge simple hepatic cyst treated with laparoscopic resection.

    Science.gov (United States)

    Kaneya, Yohei; Yoshida, Hiroshi; Matsutani, Takeshi; Hirakata, Atsushi; Matsushita, Akira; Suzuki, Seiji; Yokoyama, Tadashi; Maruyama, Hiroshi; Sasajima, Koji; Uchida, Eiji

    2011-01-01

    Most hepatic cysts are asymptomatic, but complications occasionally occur. We describe a patient with biliary obstruction due to a huge simple hepatic cyst treated with laparoscopic resection. A 60-year-old Japanese woman was admitted to our hospital because of a nontender mass in the right upper quadrant of the abdomen. Laboratory tests revealed the following: serum total bilirubin, 0.6 mg/dL; serum aspartate aminotransferase, 100 IU/L; serum alanine aminotransferase, 78 IU/L; serum alkaline phosphatase, 521 IU/L; and serum gamma glutamic transpeptidase, 298 IU/L. Abdominal computed tomography, ultrasonography, and magnetic resonance cholangiopancreatography revealed a huge hepatic cyst, 13 cm in diameter, at the hepatic hilum, accompanied by dilatation of the intrahepatic bile duct and obstruction of the common bile duct. We diagnosed biliary obstruction due to a huge hepatic cyst at the hepatic hilum, and laparoscopic surgery was performed. A huge hepatic cyst was seen at the hepatic hilum. After needle puncture of the huge cyst, the anterior wall of the cyst was unroofed, and cholecystectomy was done. Intraoperative cholangiography through a cystic duct revealed stenosis of the duct. Subsequent decapsulation of the cyst was performed in front of the common bile duct. After this procedure, cholangiography revealed that the stenosis of the common bile duct had resolved. Histopathological examination of the surgical specimen confirmed the hepatic cyst was benign. The postoperative course was uneventful, and the results of liver function tests normalized. The patient was discharged 7 days after operation. Computed tomography 3 months after operation revealed disappearance of the hepatic cyst and no dilatation of the intrahepatic bile duct.

  14. Visual search

    NARCIS (Netherlands)

    Toet, A.; Bijl, P.

    2003-01-01

    Visual search, with or without the aid of optical or electro-optical instruments, plays a significant role in various types of military and civilian operations (e.g., reconnaissance, surveillance, and search and rescue). Advance knowledge of human visual search and target acquisition performance is

  15. Research of Space Service File Digitization and Ful-text Search System%空间业务档案数字化与全文检索系统的研究

    Institute of Scientific and Technical Information of China (English)

    石会鹏; 丁鲜花; 刘国英

    2015-01-01

    本文基于OCR技术和全文检索服务器SOLR搭建了一个空间无线电业务档案数字化和全文检索系统,分别介绍了文档扫描识别、智能分析、状态管理和检索查询等功能模块,并分析了系统实现的关键技术.%This paper builds a space servicefi le digitization and full-text search system based on the OCR and full-text search server SOLR. The paper respectively introduces the functional modules such as scanned document recognition, intelligent analysis, state management and retrieval query, and analyses the key technical problems in realizing the system.

  16. Preventing Space Warfare

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The international community should join forces to avoid possible conflicts in space Military competition and conflict in outer space can be divided into three stages:militarization,wea- ponization and the space battle- field. Space militarization has become a thing of the past.Now,many countries are re- searching more advanced space weaponry technology,which means space weapon- ization is becoming a growing reality.The process of space competition is astonishingly

  17. PatchMatch Filter: Edge-Aware Filtering Meets Randomized Search for Visual Correspondence.

    Science.gov (United States)

    Lu, Jiangbo; Li, Yu; Yang, Hongsheng; Min, Dongbo; Eng, Weiyong; Do, Minh N

    2017-09-01

    Though many tasks in computer vision can be formulated elegantly as pixel-labeling problems, a typical challenge discouraging such a discrete formulation is often due to computational efficiency. Recent studies on fast cost volume filtering based on efficient edge-aware filters provide a fast alternative to solve discrete labeling problems, with the complexity independent of the support window size. However, these methods still have to step through the entire cost volume exhaustively, which makes the solution speed scale linearly with the label space size. When the label space is huge or even infinite, which is often the case for (subpixel-accurate) stereo and optical flow estimation, their computational complexity becomes quickly unacceptable. Developed to search approximate nearest neighbors rapidly, the PatchMatch method can significantly reduce the complexity dependency on the search space size. But, its pixel-wise randomized search and fragmented data access within the 3D cost volume seriously hinder the application of efficient cost slice filtering. This paper presents a generic and fast computational framework for general multi-labeling problems called PatchMatch Filter (PMF). We explore effective and efficient strategies to weave together these two fundamental techniques developed in isolation, i.e., PatchMatch-based randomized search and efficient edge-aware image filtering. By decompositing an image into compact superpixels, we also propose superpixel-based novel search strategies that generalize and improve the original PatchMatch method. Further motivated to improve the regularization strength, we propose a simple yet effective cross-scale consistency constraint, which handles labeling estimation for large low-textured regions more reliably than a single-scale PMF algorithm. Focusing on dense correspondence field estimation in this paper, we demonstrate PMF's applications in stereo and optical flow. Our PMF methods achieve top-tier correspondence

  18. Identifying Aspects for Web-Search Queries

    OpenAIRE

    Wu, Fei; Madhavan, Jayant; Halevy, Alon

    2014-01-01

    Many web-search queries serve as the beginning of an exploration of an unknown space of information, rather than looking for a specific web page. To answer such queries effec- tively, the search engine should attempt to organize the space of relevant information in a way that facilitates exploration. We describe the Aspector system that computes aspects for a given query. Each aspect is a set of search queries that together represent a distinct information need relevant to the original search...

  19. I-SG : Interactive Search Grouping - Search result grouping using Independent Component Analysis

    DEFF Research Database (Denmark)

    Lauritsen, Thomas; Kolenda, Thomas

    2002-01-01

    We present a computational simple and efficient approach to unsupervised grouping the search result from any search engine. Along with each group a set of keywords are found to annotate the contents. This approach leads to an interactive search trough a hierarchial structure that is build online....... It is the users task to improve the search, trough expanding the search query using the topic keywords representing the desired groups. In doing so the search engine limits the space of possible search results, virtually moving down in the search hierarchy, and so refines the search....

  20. Performances Evaluation of a Novel Hadoop and Spark Based System of Image Retrieval for Huge Collections

    Directory of Open Access Journals (Sweden)

    Luca Costantini

    2015-01-01

    Full Text Available A novel system of image retrieval, based on Hadoop and Spark, is presented. Managing and extracting information from Big Data is a challenging and fundamental task. For these reasons, the system is scalable and it is designed to be able to manage small collections of images as well as huge collections of images. Hadoop and Spark are based on the MapReduce framework, but they have different characteristics. The proposed system is designed to take advantage of these two technologies. The performances of the proposed system are evaluated and analysed in terms of computational cost in order to understand in which context it could be successfully used. The experimental results show that the proposed system is efficient for both small and huge collections.

  1. A New Pixels Flipping Method for Huge Watermarking Capacity of the Invoice Font Image

    Directory of Open Access Journals (Sweden)

    Li Li

    2014-01-01

    Full Text Available Invoice printing just has two-color printing, so invoice font image can be seen as binary image. To embed watermarks into invoice image, the pixels need to be flipped. The more huge the watermark is, the more the pixels need to be flipped. We proposed a new pixels flipping method in invoice image for huge watermarking capacity. The pixels flipping method includes one novel interpolation method for binary image, one flippable pixels evaluation mechanism, and one denoising method based on gravity center and chaos degree. The proposed interpolation method ensures that the invoice image keeps features well after scaling. The flippable pixels evaluation mechanism ensures that the pixels keep better connectivity and smoothness and the pattern has highest structural similarity after flipping. The proposed denoising method makes invoice font image smoother and fiter for human vision. Experiments show that the proposed flipping method not only keeps the invoice font structure well but also improves watermarking capacity.

  2. Huge mucinous cystadenoma of ovary, describing a young patient: case report

    Directory of Open Access Journals (Sweden)

    Soheila Aminimoghaddam

    2017-08-01

    Conclusion: Ovarian cysts in young women who are associated with elevated levels of tumor markers and ascites require careful evaluation. Management of ovarian cysts depends on patient's age, size of the cyst, and its histopathological nature. Conservative surgery such as ovarian cystectomy or salpingo-oophorectomy is adequate in mucinous tumors of ovary. Multiple frozen sections are very important to know the malignant variation of this tumor and helps accurate patient management. Surgical expertise is required to prevent complications in huge tumors has distorted the anatomy, so gynecologic oncologist plays a prominent role in management. In this case, beside of the huge tumor and massive ascites uterine and ovaries were preserved by gynecologist oncologist and patient is well up to now.

  3. Huge gastric diospyrobezoars successfully treated by oral intake and endoscopic injection of Coca-Cola.

    Science.gov (United States)

    Chung, Y W; Han, D S; Park, Y K; Son, B K; Paik, C H; Jeon, Y C; Sohn, J H

    2006-07-01

    A diospyrobezoar is a type of phytobezoar that is considered to be harder than any other types of phytobezoars. Here, we describe a new treatment modality, which effectively and easily disrupted huge gastric diospyrobezoars. A 41-year-old man with a history of diabetes mellitus was admitted with lower abdominal pain and vomiting. Upper gastrointestinal endoscopy revealed three huge, round diospyrobezoars in the stomach. He was made to drink two cans of Coca-Cola every 6 h. At endoscopy the next day, the bezoars were partially dissolved and turned to be softened. We performed direct endoscopic injection of Coca-Cola into each bezoar. At repeated endoscopy the next day, the bezoars were completely dissolved.

  4. Huge Neck Masses Causing Respiratory Distress in Neonates: Two Cases of Congenital Cervical Teratoma.

    Science.gov (United States)

    Gezer, Hasan Özkan; Oğuzkurt, Pelin; Temiz, Abdulkerim; Bolat, Filiz Aka; Hiçsönmez, Akgün

    2016-12-01

    Congenital cervical teratomas are rare and usually large enough to cause respiratory distress in the neonatal period. We present two cases of congenital huge cystic neck masses in which distinguishing cervical cystic hygroma and congenital cystic teratoma was not possible through radiologic imaging techniques. Experience with the first case, which was initially diagnosed and treated as cystic hygroma by injection sclerotherapy, led to early suspicion and surgery in the second case. The masses were excised completely and histopathologic diagnoses were congenital teratoma in both patients. Our aim is to review congenital huge neck masses causing respiratory distress in early neonatal life to highlight this dilemma briefly with these interesting cases. Copyright © 2014. Published by Elsevier B.V.

  5. Huge echinococcal cyst of the liver managed by hepatectomy: Report of two cases.

    Science.gov (United States)

    Pavlidis, Efstathios T; Symeonidis, Nikolaos; Psarras, Kyriakos; Pavlidis, Theodoros E

    2017-01-01

    Echinococcocal cysts are predominantly located in the right liver. They are usually solitary and asymptomatic, but large cysts can cause compression symptoms. We report two cases of huge (25cm and 20cm in diameter, respectively) echinococcal cysts located in the left liver, which presented as a large palpable mass causing compression symptoms. Diagnosis was established with CT scan showing a cystic mass with the characteristic daughter cysts and reactive layer (pericystic wall) consisting of fibrous connective tissue and calcifications. Both patients were treated radically with left hepatectomy and had uneventful postoperative course and no recurrence upon follow-up. The treatment of liver echinococcal cysts represent a unique surgical challenge. Even though conservative approaches are less technically demanding, the radical approach with resection has better outcome with less recurrences, when performed by experienced surgeons. Resection rather than drainage is the management of choice for such huge liver echinococcal cysts. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  6. The huge Package for High-dimensional Undirected Graph Estimation in R

    Science.gov (United States)

    Zhao, Tuo; Liu, Han; Roeder, Kathryn; Lafferty, John; Wasserman, Larry

    2015-01-01

    We describe an R package named huge which provides easy-to-use functions for estimating high dimensional undirected graphs from data. This package implements recent results in the literature, including Friedman et al. (2007), Liu et al. (2009, 2012) and Liu et al. (2010). Compared with the existing graph estimation package glasso, the huge package provides extra features: (1) instead of using Fortan, it is written in C, which makes the code more portable and easier to modify; (2) besides fitting Gaussian graphical models, it also provides functions for fitting high dimensional semiparametric Gaussian copula models; (3) more functions like data-dependent model selection, data generation and graph visualization; (4) a minor convergence problem of the graphical lasso algorithm is corrected; (5) the package allows the user to apply both lossless and lossy screening rules to scale up large-scale problems, making a tradeoff between computational and statistical efficiency. PMID:26834510

  7. Mitral valve regurgitation due to annular dilatation caused by a huge and floating left atrial myxoma.

    Science.gov (United States)

    Kaya, Mehmet; Ersoy, Burak; Yeniterzi, Mehmet

    2015-09-01

    We describe a case of mitral valve annular dilatation caused by a huge left atrial myxoma obstructing the mitral valve orifice. A 50-year-old man presenting with palpitation was found to have a huge left atrial myxoma protruding into the left ventricle during diastole, causing severe mitral regurgitation. The diagnosis was made with echocardiogram. Transoesophageal echocardiography revealed a solid mass of 75 × 55 mm. During operation, the myxoma was completely removed from its attachment in the atrium. We preferred to place a mechanical heart valve after an annuloplasty ring because of severely dilated mitral annulus and chordae elongation. The patient had an uneventful recovery. Our case suggests that immediate surgery, careful evaluation of mitral valve annulus preoperatively is recommended.

  8. [Resection of a Huge Gastrointestinal Stromal Tumor of the Stomach Following Neoadjuvant Chemotherapy with Imatinib].

    Science.gov (United States)

    Sato, Yoshihiro; Karasawa, Hideaki; Aoki, Takeshi; Imoto, Hirofumi; Tanaka, Naoki; Watanabe, Kazuhiro; Abe, Tomoya; Nagao, Munenori; Ohnuma, Shinobu; Musha, Hiroaki; Takahashi, Masanobu; Motoi, Fuyuhiko; Naitoh, Takeshi; Ishioka, Chikashi; Unno, Michiaki

    2016-11-01

    We report a case of a huge gastric gastrointestinal stromal tumor(GIST)that was safely resected followingpreoperative imatinib therapy. A 72-year-old woman was hospitalized with severe abdominal distension. Computed tomography revealed a 27×17 cm tumor in the left upper abdominal cavity. The patient was diagnosed with high risk GIST by EUS-FNA. We initiated preoperative adjuvant chemotherapy with imatinib to achieve a reduction of operative risks and functional preservation. After 6 months of chemotherapy, CT showed a reduction in the tumor size and the patient underwent partial gastrectomy and partial resection of the diaphragm. Histologically, most of the tumor cells were replaced by hyalinized collagen and viable cells were scattered only around the blood vessels. Neoadjuvant chemotherapy with imatinib has the potential to become an important therapeutic option for the treatment of huge GISTs.

  9. Huge mass in right side of the heart: A rare case report.

    Science.gov (United States)

    Ghasemi, Reza; Ghanei-Motlagh, Fahimeh; Nazari, Susan; Yaghubi, Mohsen

    2016-11-01

    The presence of primary intracardiac tumors are scarce, and most of them are myxomas. We reported, in this paper, a case with huge mass in the right side of the heart. A 45-year-old man, with a complaint of bilateral lower limbs edema and exertional dyspnea, was admitted to intensive cardiac care unit. Cardiac auscultation revealed soft grade systolic murmur without any evidence of "tumor plop." Echocardiography showed a huge mobile mass in right side of the heart that suggested myxoma. Our patient underwent cardiac surgery with excision of 13 cm mass. Histopathological study was confirmed the diagnosis of mass type. In this case report, it shows that in the differential diagnosis of right-sided heart failure, the right sided myxoma must be considered. The preferable approach in patient with cardiac myxomas is surgical excision to alleviate symptoms, early identification, and removal.

  10. Huge Dissected Ascending Aorta Associated with Pseudo Aneurysm and Aortic Coarctation Feridoun

    Directory of Open Access Journals (Sweden)

    Feridoun Sabzi

    2015-10-01

    Full Text Available We report a unique case of chronic dissection of the ascending aorta complicated with huge and thrombotic pseudoaneurysm in a patient with coarctation of descending aorta. Preoperative investigations such as transesophageal echocardiography (TEE confirmed the diagnosis of dissection. Intraoperative findings included a12 cm eccentric bulge of the right lateral side of dilated the ascending aorta filled with the clot and a circular shaped intimal tear communicating with an extended hematoma and dissection of the media layer. The rarity of the report is an association of the chronic dissection with huge pseudoaneurysm and coarctation. The patient underwent staged repair of an aneurysm and coarctation and had an uneventful postoperative recovery period.

  11. A new pixels flipping method for huge watermarking capacity of the invoice font image.

    Science.gov (United States)

    Li, Li; Hou, Qingzheng; Lu, Jianfeng; Xu, Qishuai; Dai, Junping; Mao, Xiaoyang; Chang, Chin-Chen

    2014-01-01

    Invoice printing just has two-color printing, so invoice font image can be seen as binary image. To embed watermarks into invoice image, the pixels need to be flipped. The more huge the watermark is, the more the pixels need to be flipped. We proposed a new pixels flipping method in invoice image for huge watermarking capacity. The pixels flipping method includes one novel interpolation method for binary image, one flippable pixels evaluation mechanism, and one denoising method based on gravity center and chaos degree. The proposed interpolation method ensures that the invoice image keeps features well after scaling. The flippable pixels evaluation mechanism ensures that the pixels keep better connectivity and smoothness and the pattern has highest structural similarity after flipping. The proposed denoising method makes invoice font image smoother and fiter for human vision. Experiments show that the proposed flipping method not only keeps the invoice font structure well but also improves watermarking capacity.

  12. Stochastic Huge-Resonance Caused by Coupling for a Globally Coupled Linear System

    Institute of Scientific and Technical Information of China (English)

    LI Jing-Hui

    2009-01-01

    In the paper, we investigate a globally coupled linear system with finite subunits subject to temporal periodic force and with multiplicative dichotomous noise.It is shown that, the global coupling among the subunits can hugely enhance the phenomenon of SR for the amplitude of the average mean field as the functions of the transition rate of the noise and that as the function of the frequency of the signal respectively.

  13. Therapeutic benefit of radiotherapy in huge (≥10 cm) unresectable hepatocellular carcinoma.

    Science.gov (United States)

    Kim, Kyung Hwan; Kim, Mi Sun; Chang, Jee Suk; Han, Kwang-Hyub; Kim, Do Young; Seong, Jinsil

    2014-05-01

    Huge (≥10 cm) hepatocellular carcinomas (HCCs) show dismal prognosis and only a limited number of cases are eligible for curative resection. We studied the therapeutic benefit of radiotherapy (RT) in patients with huge unresectable HCCs. Data from 283 patients with huge HCCs and preserved liver function who underwent non-surgical treatment from July 2001 to March 2012 were retrospectively reviewed. Patients were divided into 4 groups according to the initial treatment: Group A (N= 49), transarterial chemoembolization (TACE); Group B (N = 35), TACE + RT; Group C (N = 50), hepatic arterial infusion chemotherapy; and Group D (n = 149), concurrent chemoradiotherapy (CCRT). The median follow-up period was 27.8 months (range, 12.9-121.9 months). The median overall survival (OS) was longer in Groups B (15.3 months) and D (12.8 months) than in Groups A (7.5 months) and C (8.2 months; Group B vs. A, Bonferroni corrected P [P(c)] = 0.04; Group B vs. C, P(c) = 0.02; Group D vs. A, P(c) = 0.01; Group D vs. C, Pc = 0.006). Groups B and D also showed superior progression-free survival (PFS) and intrahepatic control than Groups A and C. In multivariate analysis, tumour multiplicity, serum alpha-foetoprotein level (≥200 ng/ml) and initial treatment were independent prognostic factors for OS and PFS. Patients with huge unresectable HCCs treated with RT, either as CCRT or in combination with TACE, showed excellent intrahepatic control and prolonged survival. RT could be considered a promising treatment modality in these patients. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. Interaction-induced huge magnetoresistance in a high mobility two-dimensional electron gas

    Energy Technology Data Exchange (ETDEWEB)

    Bockhorn, L.; Haug, R. J. [Institut für Festkörperphysik, Leibniz Universität Hannover, D-30167 Hannover (Germany); Gornyi, I. V. [Institut für Nanotechnologie, Karlsruher Institut of Technology, D-76021 Karlsruhe (Germany); Schuh, D. [Institut für Experimentelle und Angewandte Physik, Universität Regensburg, D-93053 Regensburg (Germany); Wegscheider, W. [ETH Zürich (Switzerland)

    2013-12-04

    A strong negative magnetoresistance is observed in a high-mobility two-dimensional electron gas in a GaAs/Al{sub 0.3}Ga{sub 0.7}As quantum well. We discuss that the negative magnetoresistance consists of a small peak induced by a combination of two types of disorder and a huge magnetoresistance explained by the interaction correction to the conductivity for mixed disorder.

  15. Lex-Partitioning: A New Option for BDD Search

    Directory of Open Access Journals (Sweden)

    Stefan Edelkamp

    2012-10-01

    Full Text Available For the exploration of large state spaces, symbolic search using binary decision diagrams (BDDs can save huge amounts of memory and computation time. State sets are represented and modified by accessing and manipulating their characteristic functions. BDD partitioning is used to compute the image as the disjunction of smaller subimages. In this paper, we propose a novel BDD partitioning option. The partitioning is lexicographical in the binary representation of the states contained in the set that is represented by a BDD and uniform with respect to the number of states represented. The motivation of controlling the state set sizes in the partitioning is to eventually bridge the gap between explicit and symbolic search. Let n be the size of the binary state vector. We propose an O(n ranking and unranking scheme that supports negated edges and operates on top of precomputed satcount values. For the uniform split of a BDD, we then use unranking to provide paths along which we partition the BDDs. In a shared BDD representation the efforts are O(n. The algorithms are fully integrated in the CUDD library and evaluated in strongly solving general game playing benchmarks.

  16. Post-renal acute renal failure due to a huge bladder stone.

    Science.gov (United States)

    Celik, Orcun; Suelozgen, Tufan; Budak, Salih; Ilbey, Yusuf Ozlem

    2014-06-30

    A 63-year old male was referred to our emergency unit due to acute renal failure. The level of serum renal function tests levels, blood urea nitrogen (BUN)/creatinine, were 63 mmol/L/848 μmol/L. CT (Computarised Tomography) scan showed a huge bladder stone (5 cm x 6 cm x 5 cm) with increased bladder wall thickness. Post-renal acute renal failure due to bilateral ureterohydronephrosis was diagnosed. The huge bladder stone was considered to be the cause of ureterohydronephrosis and renal failure. The patient was catheterised and received haemodialysis immediately. He received haemodialysis four times during ten days of hospitalization and the level of serum renal function tests levels (BUN/ creatinine) decreased 18 mmol/L/123 μmol/L. After improvement of renal function, we performed cystoscopy that demonstrated normal prostatic urethra and bladder neck and bilaterally normal ureteral orifices. Bladder wall was roughly trabeculated and Bladder outlet was completely obstructed by a huge bladder stone. After cystoscopy open, cystolithotomy was performed to remove calcium phosphate and magnesium ammonium phosphate stone weighing 200 g removed. Four days after operation the patient was discharged uneventfully and urethral catheter was removed on the seventh day. Post-renal acute renal failure due to large bladder stones is rare in literature. According to the our knowledge; early diagnosis of the stone avoid growth to large size and prevent renal failure.

  17. Modified concentric craniotomy for the removal of a huge calvarial metastatic tumor: technical note.

    Science.gov (United States)

    Kao, Ying; Yang, Shih-Hung; Kuo, Meng-Fai

    2016-02-01

    It is challenging for neurosurgeons to remove huge tumors involving the skull that may possibly invade the dura or intracranial neural tissue. In this situation, excision of the tumor may cause profound blood loss, unexpected opening of the dura, or neurological injury. We describe a technique of craniotomy in a pediatric patient to avoid surgical complications. A 15-year-old boy had a huge metastatic calvarial Ewing's sarcoma. We removed the tumor successfully with modified concentric craniotomy. First, two oval burr holes are made on both sides of the tumor. The inner craniotomy uses the internal margin of the oval holes, while the outer cut uses the outer margins. The skull bone in between the two craniotomies is removed easily in two pieces and the dura surrounding the tumor can be exposed early in the procedure. In this way, the huge skull tumor can be removed en bloc under direct vision to avoid unwanted complications. Minimal blood and bone loss can be achieved. Blood transfusion was not necessary during the surgery. The patient did not have new neurological symptoms and signs after surgery. The goal of the modified concentric craniotomy is to develop an accessible margin of the dura surrounding the bulky tumor in the early phase of surgery. Blood and bone loss can be reduced significantly.

  18. Intraoperative fluorescent cholangiography using indocyanine green for laparoscopic fenestration of nonparasitic huge liver cysts.

    Science.gov (United States)

    Kitajima, Toshihiro; Fujimoto, Yasuhiro; Hatano, Etsuro; Mitsunori, Yusuke; Tomiyama, Koji; Taura, Kojiro; Mizumoto, Masaki; Uemoto, Shinji

    2015-02-01

    Bile duct injury is one of the known serious complications of laparoscopic fenestration for nonparasitic liver cysts. Herein, we report the case of a huge liver cyst for which we performed laparoscopic fenestration using intraoperative fluorescent cholangiography with indocyanine green. A 71-year-old woman with abdominal distention was referred to our hospital. CT demonstrated a 17 × 11.5-cm simple cyst replacing the right lobe of the liver, so laparoscopic fenestration was performed. Although the biliary duct could not be detected because of compression by the huge cyst, fluorescent cholangiography with indocyanine green through endoscopic naso-biliary drainage tube clearly delineated the intrahepatic bile duct in the remaining cystic wall. The patient had no complications at 3 months after surgery. Fluorescent cholangiography using indocyanine green is a safe and effective procedure to avoid bile duct injury during laparoscopic fenestration, especially in patients with a huge liver cyst. © 2015 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Wiley Publishing Asia Pty Ltd.

  19. Efficacy of hepatic resection vs transarterial chemoembolization for solitary huge hepatocellular carcinoma.

    Science.gov (United States)

    Zhu, Shao-Liang; Zhong, Jian-Hong; Ke, Yang; Ma, Liang; You, Xue-Mei; Li, Le-Qun

    2015-08-28

    To compare the efficacy of hepatic resection (HR) and transarterial chemoembolization (TACE) for patients with solitary huge (≥ 10 cm) hepatocellular carcinoma (HCC). Records were retrospectively analyzed of 247 patients with solitary huge HCC, comprising 180 treated by HR and 67 by TACE. Long-term overall survival (OS) was compared between the two groups using the Kaplan-Meier method, and independent predictors of survival were identified by multivariate analysis. These analyses were performed using all patients in both groups and/or 61 pairs of propensity score-matched patients from the two groups. OS at 5 years was significantly higher in the HR group than the TACE group, across all patients (P = 0.002) and across propensity score-matched pairs (36.4% vs 18.2%, P = 0.039). The two groups showed similar postoperative mortality and morbidity. Multivariate analysis identified alpha-fetoprotein ≥ 400 ng/mL, presence of vascular invasion and TACE treatment as independent predictors of poor OS. Our findings suggest that HR can be safe and more effective than TACE for patients with solitary huge HCC.

  20. Huge Intramural Hematoma in a Thrombosed Middle Cerebral Artery Aneurysm: A Case Report.

    Science.gov (United States)

    Kim, Hak Jin; Lee, Sang Won; Lee, Tae Hong; Kim, Young Soo

    2015-09-01

    We describe a case of a huge intramural hematoma in a thrombosed middle cerebral artery aneurysm. A 47-year-old female patient with liver cirrhosis and thrombocytopenia presented to the neurosurgical unit with a 5-day history of headache and cognitive dysfunction. Magnetic resonance imaging and computed tomography of the brain showed a thrombosed aneurysm located in the right middle cerebral artery with a posteriorly located huge intramural hematoma mimicking an intracerebral hematoma. Imaging studies and cerebrospinal fluid analysis showed no evidence of subarachnoid hemorrhage. Angiography showed a partially thrombosed aneurysm at the origin of the right anterior temporal artery and an incidental aneurysm at the bifurcation of the right middle cerebral artery. Both aneurysms were embolized by coiling. After embolization, the thrombosed aneurysmal sac and intramural hematoma had decreased in size 4 days later and almost completely disappeared 8 months later. This is the first reported case of a nondissecting, nonfusiform aneurysm with a huge intramural hematoma, unlike that of a dissecting aneurysm.

  1. LHCb Exotica and Higgs searches

    CERN Multimedia

    Lucchesi, Donatella

    2016-01-01

    The unique phase space coverage and features of the LHCb detector at the LHC makes it an ideal environment to probe complementary New Physics parameter regions. In particular, recently developed jet tagging algorithms are ideal for searches involving $b$ and $c$ jets. This poster will review different jet-related exotica searches together with the efforts in the search for a Higgs boson decaying to a pair of heavy quarks.

  2. Variable Neighbourhood Search and Mathematical Programming for Just-in-Time Job-Shop Scheduling Problem

    Directory of Open Access Journals (Sweden)

    Sunxin Wang

    2014-01-01

    Full Text Available This paper presents a combination of variable neighbourhood search and mathematical programming to minimize the sum of earliness and tardiness penalty costs of all operations for just-in-time job-shop scheduling problem (JITJSSP. Unlike classical E/T scheduling problem with each job having its earliness or tardiness penalty cost, each operation in this paper has its earliness and tardiness penalties, which are paid if the operation is completed before or after its due date. Our hybrid algorithm combines (i a variable neighbourhood search procedure to explore the huge feasible solution spaces efficiently by alternating the swap and insertion neighbourhood structures and (ii a mathematical programming model to optimize the completion times of the operations for a given solution in each iteration procedure. Additionally, a threshold accepting mechanism is proposed to diversify the local search of variable neighbourhood search. Computational results on the 72 benchmark instances show that our algorithm can obtain the best known solution for 40 problems, and the best known solutions for 33 problems are updated.

  3. Searching the Higgs with the Neurochip TOTEM

    OpenAIRE

    Dusini, S.; Ferrari, F; Lazzizzera, I.; Sartori, A; Sidoti, A; Tecchiolli, G.

    1997-01-01

    We show that neural network classifiers can be helpful in discriminating Higgs production events from the huge background at LHC, assuming the case of a mass value $M_H \\sim 200$ GeV. We use the high performance neurochip TOTEM, trained by the Reactive Tabu Search algorithm (RTS), which could be used for on-line purposes. Two different sets of input variables are compared.

  4. Searching the Higgs with the Neurochip TOTEM

    CERN Document Server

    Dusini, S; Lazzizzera, I; Sartori, A; Sidoti, A; Tecchiolli, G P

    1998-01-01

    We show that neural network classifiers can be helpful in discriminating Higgs production events from the huge background at LHC, assuming the case of a mass value $M_H \\sim 200$ GeV. We use the high performance neurochip TOTEM, trained by the Reactive Tabu Search algorithm (RTS), which could be used for on-line purposes. Two different sets of input variables are compared.

  5. Searching the Higgs with the Neurochip TOTEM

    OpenAIRE

    Dusini, S.; Ferrari, F.; Lazzizzera, I.; SARTORI,A.; Sidoti, A.; Tecchiolli, G.

    1997-01-01

    We show that neural network classifiers can be helpful in discriminating Higgs production events from the huge background at LHC, assuming the case of a mass value $M_H \\sim 200$ GeV. We use the high performance neurochip TOTEM, trained by the Reactive Tabu Search algorithm (RTS), which could be used for on-line purposes. Two different sets of input variables are compared.

  6. Searching the Higgs with the neurochip TOTEM

    Science.gov (United States)

    Dusini, S.; Ferrari, F.; Lazzizzera, I.; Sartori, A.; Sidoti, A.; Tecchiolli, G.

    1998-06-01

    We show that neural network classifiers can be helpful in discriminating Higgs production events from the huge background at LHC, assuming the case of a mass value M H ˜ 200 GeV. We use the high performance neurochip TOTEM, trained by the Reactive Tabu Search algorithm (RTS), which could be used for on-line purposes. Two different sets of input variables are compared.

  7. Searching the Higgs with the neurochip TOTEM

    Energy Technology Data Exchange (ETDEWEB)

    Dusini, S.; Lazzizzera, I.; Sidoti, A. [Trento Univ. (Italy). Dipt. di Fisica]|[Istituto Nazionale di Fisica Nucleare, Padua (Italy); Ferrari, F. [Trento Univ. (Italy). Dipt. di Fisica]|[Paris-5 Univ., 75 (France). Lab. des Physique Theorique et Hautes Energies; Sartori, A.; Tecchiolli, G. [Istituto per la Ricerca Scientifica e Tecnologica, Trento (Italy)]|[Istituto Nazionale di Fisica Nucleare, Padua (Italy)

    1998-06-01

    We show that neural network classifiers can be helpful in discriminating Higgs production events from the huge background at LHC, assuming the case of a mass value M{sub H} {proportional_to} 200 GeV. We use the high performance neurochip TOTEM, trained by the Reactive Tabu Search algorithm (RTS), which could be used for on-line purposes. Two different sets of input variables are compared. (orig.). 17 refs.

  8. Semantic Search of Web Services

    Science.gov (United States)

    Hao, Ke

    2013-01-01

    This dissertation addresses semantic search of Web services using natural language processing. We first survey various existing approaches, focusing on the fact that the expensive costs of current semantic annotation frameworks result in limited use of semantic search for large scale applications. We then propose a vector space model based service…

  9. Semantic Search of Web Services

    Science.gov (United States)

    Hao, Ke

    2013-01-01

    This dissertation addresses semantic search of Web services using natural language processing. We first survey various existing approaches, focusing on the fact that the expensive costs of current semantic annotation frameworks result in limited use of semantic search for large scale applications. We then propose a vector space model based service…

  10. Search for lightly ionizing particles using CDMS-II data and fabrication of CDMS detectors with improved homogeneity in properties

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, Kunj Bihari [Texas A & M Univ., College Station, TX (United States)

    2013-12-01

    Fundamental particles are always observed to carry charges which are integral multiples of one-third charge of electron, e/3. While this is a well established experimental fact, the theoretical understanding for the charge quantization phenomenon is lacking. On the other hand, there exist numerous theoretical models that naturally allow for existence of particles with fractional electromagnetic charge. These particles, if existing, hint towards existence of physics beyond the standard model. Multiple high energy, optical, cosmological and astrophysical considerations restrict the allowable mass-charge parameter space for these fractional charges. Still, a huge unexplored region remains. The Cryogenic Dark Matter Search (CDMS-II), located at Soudan mines in northern Minnesota, employs germanium and silicon crystals to perform direct searches for a leading candidate to dark matter called Weakly Interacting Massive Particles (WIMPs). Alternately, the low detection threshold allows search for fractional electromagnetic-charged particles, or Lightly Ionizing Particles (LIPs), moving at relativistic speed. Background rejection is obtained by requiring that the magnitude and location of energy deposited in each detector be consistent with corresponding \\signatures" resulting from the passage of a fractionally charged particle. In this dissertation, the CDMS-II data is analyzed to search for LIPs, with an expected background of 0.078 0.078 events. No candidate events are observed, allowing exclusion of new parameter space for charges between e/6 and e/200.

  11. Recent highlights from SUSY searches at CMS

    CERN Document Server

    Rathjens, Denis

    2015-01-01

    The variety of searches shown ranges from an inclusive all-jet search for strong production of sparticles over a search employing $\\tilde{t}$-tagging techniques and a search for a di-leptonic mass edge, jets and ${E\\!\\!\\!\\!\\!/_{\\rm T}}$ to the first search for vector boson fusion (VBF) production of $\\tilde{\\tau}$ in a compressed mass-spectrum scenario. In summary, the large coverage of supersymmetric parameter space by the CMS collaboration is demonstrated.

  12. Faceted Search

    CERN Document Server

    Tunkelang, Daniel

    2009-01-01

    We live in an information age that requires us, more than ever, to represent, access, and use information. Over the last several decades, we have developed a modern science and technology for information retrieval, relentlessly pursuing the vision of a "memex" that Vannevar Bush proposed in his seminal article, "As We May Think." Faceted search plays a key role in this program. Faceted search addresses weaknesses of conventional search approaches and has emerged as a foundation for interactive information retrieval. User studies demonstrate that faceted search provides more

  13. Disaster Characteristics and Mitigation Measures of Huge Glacial Debris Flows along the Sichuan-Tibet Railway

    Science.gov (United States)

    Liu, Jinfeng; You, Yong; Zhang, Guangze; Wang, Dong; Chen, Jiangang; Chen, Huayong

    2017-04-01

    The Ranwu-Tongmai section of the Sichuan-Tibet Railway passes through the Palongzangbu River basin which locates in the southeast Qinghai-Tibetan Plateau. Due to widely distributed maritime glacier in this area, the huge glacier debris flows are very developed. Consequently, the disastrous glacier debris flows with huge scale (106-108 m3 for one debris flow event) and damage become one of the key influencing factors for the route alignment of the Sichuan-Tibet Railway. The research on disaster characteristics and mitigation measures of huge glacial debris flows in the study area were conducted by the remote sensing interpretation, field investigation, parameter calculation and numerical simulation. Firstly, the distribution of the glaciers, glacier lakes and glacier debris flows were identified and classified; and the disaster characteristics for the huge glacier debris flow were analyzed and summarized. Secondly, the dynamic parameters including the flood peak discharge, debris flow peak discharge, velocity, total volume of a single debris flow event were calculated. Based on the disaster characteristics and the spatial relation with the railway, some mitigation principles and measures were proposed. Finally, the Guxiang Gully, where a huge glacier debris flow with 2*108m3 in volume occurred in 1953, was selected as a typical case to analyze its disaster characteristics and mitigation measures. The interpretation results show that the glacier area is about 970 km2 which accounts for 19% of the total study area. 130 glacier lakes and 102 glacier debris flows were identified and classified. The Sichuan-Tibet Railway passes through 43 glacier debris flows in the study area. The specific disaster characteristics were analyzed and corresponding mitigation measures were proposed for the route selection of the railway. For the Guxiang Gully, a numerical simulation to simulate the deposition condition at the alluvial fan was conducted. the simulation results show that the

  14. Organic chemistry in space

    Science.gov (United States)

    Johnson, R. D.

    1977-01-01

    Organic cosmochemistry, organic materials in space exploration, and biochemistry of man in space are briefly surveyed. A model of Jupiter's atmosphere is considered, and the search for organic molecules in the solar system and in interstellar space is discussed. Materials and analytical techniques relevant to space exploration are indicated, and the blood and urine analyses performed on Skylab are described.

  15. On the Technological Improvement of Search Engines%试论搜索引擎的技术改进

    Institute of Scientific and Technical Information of China (English)

    赵丹群; 喀碧竹

    2003-01-01

    As a new and important tool for searching huge amount of information on the Web, search engine hasmade rapid progress in recent years. Meanwhile, it' s confronted with various problems. This article discusses the im-provement of search engines from 3 aspects, that is, changing the search mode, using the theory and knowledge of tradi-tional information retrieval and reinforcing post-processing of search results.

  16. Search for $CP$ violation in the phase space of $D^0\\rightarrow\\pi^+\\pi^-\\pi^+\\pi^-$ decays arXiv

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Archilli, Flavio; d'Argent, Philippe; Arnau Romeu, Joan; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Babuschkin, Igor; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baker, Sophie; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Baszczyk, Mateusz; Batozskaya, Varvara; Batsukh, Baasansuren; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Bellee, Violaine; Belloli, Nicoletta; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Betancourt, Christopher; Betti, Federico; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bezshyiko, Iaroslava; Bifani, Simone; Billoir, Pierre; Bird, Thomas; Birnkraut, Alex; Bitadze, Alexander; Bizzeti, Andrea; Blake, Thomas; Blanc, Frederic; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Boettcher, Thomas; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Bordyuzhin, Igor; Borgheresi, Alessio; Borghi, Silvia; Borisyak, Maxim; Borsato, Martino; Bossu, Francesco; Boubdir, Meriem; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Buchanan, Emma; Burr, Christopher; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel Hugo; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Chamont, David; Charles, Matthew; Charpentier, Philippe; Chatzikonstantinidis, Georgios; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chobanova, Veronika; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombs, George; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Costa Sobral, Cayo Mar; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Da Cunha Marinho, Franciole; Dall'Occo, Elena; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Aguiar Francisco, Oscar; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Serio, Marilisa; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Demmer, Moritz; Dendek, Adam; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Dijkstra, Hans; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Dungs, Kevin; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Déléage, Nicolas; Easo, Sajan; Ebert, Marcus; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Farley, Nathanael; Farry, Stephen; Fay, Robert; Fazzini, Davide; Ferguson, Dianne; Fernandez Prieto, Antonio; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fini, Rosa Anna; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fleuret, Frederic; Fohl, Klaus; Fontana, Marianna; Fontanelli, Flavio; Forshaw, Dean Charles; Forty, Roger; Franco Lima, Vinicius; Frank, Markus; Frei, Christoph; Fu, Jinlin; Furfaro, Emiliano; Färber, Christian; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garcia Martin, Luis Miguel; García Pardiñas, Julián; Garra Tico, Jordi; Garrido, Lluis; Garsed, Philip John; Gascon, David; Gaspar, Clara; Gavardi, Laura; Gazzoni, Giulio; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gizdov, Konstantin; Gligorov, Vladimir; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gorelov, Igor Vladimirovich; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Griffith, Peter; Grillo, Lucia; Gruberg Cazon, Barak Raimond; Grünberg, Oliver; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Göbel, Carla; Hadavizadeh, Thomas; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; Hatch, Mark; He, Jibo; Head, Timothy; Heister, Arno; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hombach, Christoph; Hopchev, P H; Hulsbergen, Wouter; Humair, Thibaud; Hushchyn, Mikhail; Hussain, Nazim; Hutchcroft, David; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jiang, Feng; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Kariuki, James Mwangi; Karodia, Sarah; Kecke, Matthieu; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khairullin, Egor; Khanji, Basem; Khurewathanakul, Chitsanu; Kirn, Thomas; Klaver, Suzanne; Klimaszewski, Konrad; Koliiev, Serhii; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Kosmyntseva, Alena; Kozachuk, Anastasiia; Kozeiha, Mohamad; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krokovny, Pavel; Kruse, Florian; Krzemien, Wojciech; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kurek, Krzysztof; Kvaratskheliya, Tengiz; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lanfranchi, Gaia; Langenbruch, Christoph; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Leflat, Alexander; Lefrançois, Jacques; Lefèvre, Regis; Lemaitre, Florian; Lemos Cid, Edgar; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Xuesong; Loh, David; Longstaff, Iain; Lopes, Jose; Lucchesi, Donatella; Lucio Martinez, Miriam; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Lusiani, Alberto; Lyu, Xiao-Rui; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Maltsev, Timofei; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Marks, Jörg; Martellotti, Giuseppe; Martin, Morgan; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massacrier, Laure Marie; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Melnychuk, Dmytro; Merk, Marcel; Merli, Andrea; Michielin, Emanuele; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Mogini, Andrea; Molina Rodriguez, Josue; Monroy, Ignacio Alberto; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Mulder, Mick; Mussini, Manuel; Müller, Dominik; Müller, Janine; Müller, Katharina; Müller, Vanessa; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nandi, Anita; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi Dung; Nguyen-Mau, Chung; Nieswand, Simon; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Oldeman, Rudolf; Onderwater, Gerco; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Pais, Preema Rennee; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parker, William; Parkes, Christopher; Passaleva, Giovanni; Pastore, Alessandra; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petrov, Aleksandr; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pikies, Malgorzata; Pinci, Davide; Pistone, Alessandro; Piucci, Alessio; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Pomery, Gabriela Johanna; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Poslavskii, Stanislav; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rama, Matteo; Ramos Pernas, Miguel; Rangel, Murilo; Raniuk, Iurii; Ratnikov, Fedor; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; dos Reis, Alberto; Remon Alepuz, Clara; Renaudin, Victor; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vicente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Rogozhnikov, Alexey; Roiser, Stefan; Rollings, Alexandra Paige; Romanovskiy, Vladimir; Romero Vidal, Antonio; Ronayne, John William; Rotondo, Marcello; Rudolph, Matthew Scott; Ruf, Thomas; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sadykhov, Elnur; Sagidova, Naylya; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schael, Stefan; Schellenberg, Margarete; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubert, Konstantin; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sergi, Antonino; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Siddi, Benedetto Gianluca; Silva Coutinho, Rafael; Silva de Oliveira, Luiz Gustavo; Simi, Gabriele; Simone, Saverio; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Eluned; Smith, Iwan Thomas; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Stefko, Pavol; Stefkova, Slavorima; Steinkamp, Olaf; Stemmle, Simon; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Syropoulos, Vasileios; Szczekowski, Marek; Szumlak, Tomasz; T'Jampens, Stephane; Tayduganov, Andrey; Tekampe, Tobias; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Eric; van Tilburg, Jeroen; Tilley, Matthew James; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Toriello, Francis; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Traill, Murdo; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tully, Alison; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valassi, Andrea; Valat, Sebastien; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vecchi, Stefania; van Veghel, Maarten; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Venkateswaran, Aravindhan; Vernet, Maxime; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Viemann, Harald; Vilasis-Cardona, Xavier; Vitti, Marcela; Volkov, Vladimir; Vollhardt, Achim; Voneki, Balazs; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Vázquez Sierra, Carlos; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wang, Jianchun; Ward, David; Wark, Heather Mckenzie; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wicht, Jean; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Williams, Timothy; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wraight, Kenneth; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yao, Yuezhe; Yin, Hang; Yu, Jiesheng; Yuan, Xuhao; Yushchenko, Oleg; Zarebski, Kristian Alexander; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhang, Yu; Zhelezov, Alexey; Zheng, Yangheng; Zhokhov, Anatoly; Zhu, Xianglei; Zhukov, Valery; Zucchelli, Stefano

    A search for time-integrated $CP$ violation in the Cabibbo-suppressed decay \\mbox{$D^0\\rightarrow\\pi^+\\pi^-\\pi^+\\pi^-$} is performed using an unbinned, model-independent technique known as the energy test. This is the first application of the energy test in four-body decays. The search is performed for $P$-even $CP$ asymmetries and, for the first time, is extended to probe the $P$-odd case. Using proton-proton collision data corresponding to an integrated luminosity of 3.0~fb$^{-1}$ collected by the LHCb detector at centre-of-mass energies of $\\sqrt{s}=$7~TeV and 8~TeV, the world's best sensitivity to $CP$ violation in this decay is obtained. The data are found to be consistent with the hypothesis of $CP$ symmetry with a $p$-value of $(4.6\\pm0.5)\\%$ in the $P$-even case, and marginally consistent with a $p$-value of $(0.6\\pm0.2)\\%$ in the $P$-odd case, corresponding to a significance for $CP$ non-conservation of 2.7 standard deviations.

  17. Direct policy search

    DEFF Research Database (Denmark)

    Heidrich-Meisner, V.; Igel, Christian

    2010-01-01

    process. Exploration is realized by stochastic perturbations, which can be applied at different levels. When considering direct policy search in the space of neural network policies, exploration can be applied on the synaptic level or on the level of neuronal activity. We propose neuroevolution strategies...... (NeuroESs) for direct policy search in RL. Learning using NeuroESs can be interpreted as modelling of extrinsic perturbations on the level of synaptic weights. In contrast, policy gradient methods (PGMs) can be regarded as intrinsic perturbation of neuronal activity. We compare these two approaches...

  18. Ontology-Based Search of Genomic Metadata.

    Science.gov (United States)

    Fernandez, Javier D; Lenzerini, Maurizio; Masseroli, Marco; Venco, Francesco; Ceri, Stefano

    2016-01-01

    The Encyclopedia of DNA Elements (ENCODE) is a huge and still expanding public repository of more than 4,000 experiments and 25,000 data files, assembled by a large international consortium since 2007; unknown biological knowledge can be extracted from these huge and largely unexplored data, leading to data-driven genomic, transcriptomic, and epigenomic discoveries. Yet, search of relevant datasets for knowledge discovery is limitedly supported: metadata describing ENCODE datasets are quite simple and incomplete, and not described by a coherent underlying ontology. Here, we show how to overcome this limitation, by adopting an ENCODE metadata searching approach which uses high-quality ontological knowledge and state-of-the-art indexing technologies. Specifically, we developed S.O.S. GeM (http://www.bioinformatics.deib.polimi.it/SOSGeM/), a system supporting effective semantic search and retrieval of ENCODE datasets. First, we constructed a Semantic Knowledge Base by starting with concepts extracted from ENCODE metadata, matched to and expanded on biomedical ontologies integrated in the well-established Unified Medical Language System. We prove that this inference method is sound and complete. Then, we leveraged the Semantic Knowledge Base to semantically search ENCODE data from arbitrary biologists' queries. This allows correctly finding more datasets than those extracted by a purely syntactic search, as supported by the other available systems. We empirically show the relevance of found datasets to the biologists' queries.

  19. baobabLUNA: the solution space of sorting by reversals.

    Science.gov (United States)

    Braga, Marília D V

    2009-07-15

    Computing the reversal distance and searching for an optimal sequence of reversals to transform a unichromosomal genome into another are useful algorithmic tools to analyse real evolutionary scenarios. Currently, these problems can be solved by at least two available softwares, the prominent of which are GRAPPA and GRIMM. However, the number of different optimal sequences is usually huge and taking only the distance and/or one example is often insufficient to do a proper analysis. Here, we offer an alternative and present baobabLUNA, a framework that contains an algorithm to give a compact representation of the whole space of solutions for the sorting by reversals problem. Compiled code implemented in Java is freely available for download at http://pbil.univ-lyon1.fr/software/luna/. Documentation with methodological background, technical aspects, download and setup instructions, interface description and tutorial are available at http://pbil.univ-lyon1.fr/software/luna/doc/luna-doc.pdf.

  20. High platelet counts increase metastatic risk in huge hepatocellular carcinoma undergoing transarterial chemoembolization.

    Science.gov (United States)

    Xue, Tong-Chun; Ge, Ning-Ling; Xu, Xin; Le, Fan; Zhang, Bo-Heng; Wang, Yan-Hong

    2016-09-01

    Accumulating evidence suggests platelets play critical roles in tumor metastasis. Moreover, the role of platelets in metastasis is partially correlated with inflammation. However, evidence regarding the contribution of platelets to hepatocellular carcinoma (HCC) metastasis is lacking. This study investigated the association between platelets and metastatic risk in HCC. We used huge HCC (diameter over 10 cm), a tumor subgroup with a strong inflammatory background, as a model to evaluate the potential predictive role of platelets and platelet-related biomarkers for metastasis in HCC patients undergoing transarterial chemoembolization. A logistic regression model was used to analyze risk factors for metastasis. Patients with huge HCC (n = 178) were enrolled, and 24.7% (44/178) of patients had remote metastases after treatment. Univariate analyses showed high platelet counts (P = 0.012), pretreatment platelet-to-lymphocyte ratios (pre-PLR) of 100 or more (P = 0.018) and post-PLR of 100 or more (P = 0.013) were potential risk factors for metastasis. Furthermore, multivariate analyses showed high platelet counts (odds ratio, 2.18; 95% confidence interval, 1.074-4.443; P = 0.031) and platelet-related biomarkers were independent risk factors for HCC metastasis. Particularly, the risk of metastasis in patients with high post-PLR values was significantly greater than patients with low post-PLR values. For tumor response and survival, patients with high platelet counts had faster disease progression (P = 0.002) and worse survival (P huge HCC undergoing chemoembolization, which supply clinical verification of the association between high platelet counts and HCC metastasis. © 2016 The Japan Society of Hepatology.

  1. The efficacy of stereotactic body radiation therapy on huge hepatocellular carcinoma unsuitable for other local modalities.

    Science.gov (United States)

    Que, Jenny Y; Lin, Li-Ching; Lin, Kuei-Li; Lin, Chia-Hui; Lin, Yu-Wei; Yang, Ching-Chieh

    2014-05-28

    To evaluate the safety and efficacy of Cyberknife stereotactic body radiation therapy (SBRT) and its effect on survival in patients with unresectable huge hepatocellular carcinoma (HCC) unsuitable of other standard treatment option. Between 2009 and 2011, 22 patients with unresectable huge HCC (≧10 cm) were treated with SBRT. dose ranged from 26 Gy to 40 Gy in five fractions. Overall survival (OS) and disease-progression free survival (DPFS) were determined by Kaplan-Meier analysis. Tumor response and toxicities were also assessed. After a median follow-up of 11.5 month (range 2-46 months). The objective response rate was achieved in 86.3% (complete response (CR): 22.7% and partial response (PR): 63.6%). The 1-yr. local control rate was 55.56%. The 1-year OS was 50% and median survival was 11 months (range 2-46 months). In univariate analysis, Child-Pugh stage (p = 0.0056) and SBRT dose (p = 0.0017) were significant factors for survival. However, in multivariate analysis, SBRT dose (p = 0.0072) was the most significant factor, while Child-Pugh stage of borderline significance. (p = 0.0514). Acute toxicities were mild and well tolerated. This study showed that SBRT can be delivered safely to huge HCC and achieved a substantial tumor regression and survival. The results suggest this technique should be considered a salvage treatment. However, local and regional recurrence remain the major cause of failure. Further studies of combination of SBRT and other treatment modalities may be reasonable.

  2. The big, large and huge case of state-building

    DEFF Research Database (Denmark)

    Harste, Gorm

      Using communication theory as point of departure, it is not evident how to study macro phenomena. Michel Foucault limited his studies to a non-Grand Theory when studying discursive events. At the same time, Charles Tilly wrote about Big Structures, Large Processes, Huge Comparisons when trying...... to establish a perspective on a macro phenomena as European state formation. With Luhmann's system theory, the claim is that there is no such contradiction between Grand evolution and particular semantic history. Passing through some classic studies of the historical establishment of interaction systems...

  3. The  Big, Large and Huge Case of State-Building

    DEFF Research Database (Denmark)

    Harste, Gorm

    2009-01-01

      Using communication theory as point of departure it is not evident how to study macro phenomena. Michel Foucault delimited his studies to a non-Grand Theory when he studied discursive events. At the same time Charles Tilly wrote about Big Structures, Large Processes, Huge Comparisons when he...... tried to establish a perspective on a macro phenomena as European state formation. With Luhmann's system theory, the claim is that there is no such contradiction between Grand evolution and particular semantic history. Passing through some classic studies of the historical establishment of interaction...

  4. Huge malignant phyllodes breast tumor: a real entity in a new era of early breast cancer.

    Science.gov (United States)

    Testori, Alberto; Meroni, Stefano; Errico, Valentina; Travaglini, Roberto; Voulaz, Emanuele; Alloisio, Marco

    2015-02-27

    Phyllodes tumor is an extremely rare tumor of the breast. It occurs in females in the third and fourth decades. The difficulty in distinguishing between phyllodes tumors and benign fibroadenoma may lead to misdiagnosis. Lymph node involvement is rarely described in phyllodes tumors; for this reason, sentinel node biopsy may be warranted. We present a case of a 33-year-old woman affected by huge tumor of the right breast with ulceration in the skin with a rapid tumor growth and with omolateral axillary metastasis.

  5. Huge Benign Ovarian Cystic Teratoma in a Patient with a History of Hansen's Disease.

    Science.gov (United States)

    Okonta, Patrick I; Mofon, Chukwuemeke

    2014-01-01

    Mature ovarian cystic teratomas are common benign ovarian neoplasm derived from germ cells. With increasing availability of ultrasound services even in developing countries, the diagnosis of benign ovarian tumour is made earlier and the size of the ovarian tumour at diagnosis is relatively small. It is unusual to find an ovarian cystic teratoma larger than 10 cm. We report a huge mature ovarian cystic teratoma in a multipara with a history of Hansen's disease. We conclude that, in circumstances where women have restricted access to health care, the unusual finding of mature ovarian cystic teratoma larger than 10 cm is possible due to delayed presentation for diagnosis and treatment.

  6. Huge capacity fiber-optic sensing network based on ultra-weak draw tower gratings

    Science.gov (United States)

    Yang, Minghong; Bai, Wei; Guo, Huiyong; Wen, Hongqiao; Yu, Haihu; Jiang, Desheng

    2016-03-01

    This paper reviews the work on huge capacity fiber-optic sensing network based on ultra-weak draw tower gratings developed at the National Engineering Laboratory for Fiber Optic Sensing Technology (NEL-FOST), Wuhan University of Technology, China. A versatile drawing tower grating sensor network based on ultra-weak fiber Bragg gratings (FBGs) is firstly proposed and demonstrated. The sensing network is interrogated with time- and wavelength-division multiplexing method, which is very promising for the large-scale sensing network.

  7. En bloc resection of huge cemento-ossifying fibroma of mandible: avoiding lower lip split incision.

    Science.gov (United States)

    Ayub, Tahera; Katpar, Shahjahan; Shafique, Salman; Mirza, Talat

    2011-05-01

    Cemento-ossifying Fibroma (COF) is an osteogenic benign neoplasm affecting the jaws and other craniofacial bones. It commonly presents as a progressively slow growing pathology, which can sometimes attain an enormous size, causing facial deformity. A case of a huge cemento-ossifying fibroma, appearing as a mandibular dumbell tumour in a male patient is documented, which caused massive bone destruction and deformity. It was surgically removed by performing en bloc resection of mandible avoiding the splitting of lower lip incision technique, thereby maintaining his normal facial appearance.

  8. Huge Intrathoracic Malignant Peripheral Nerve Sheath Tumor in an Adolescent with Neurofibromatosis Type 1

    Directory of Open Access Journals (Sweden)

    Jong Hyung Yoon

    2014-01-01

    Full Text Available Malignant peripheral nerve sheath tumor (MPNST is a rare soft tissue malignancy usually found in patients with neurofibromatosis type 1 (NF1 with a poor outcome. Although MPNST can be found in any part of the body including head and neck or extremities, intrathoracic MPNST with or without NF1 is uncommon, especially in children or adolescents. Reported herein is a case of huge intrathoracic MPNST in a 16-year-old girl with NF1, and a brief review of the literature.

  9. Huge gastric bezoar caused by honeycomb, an unusual complication of health faddism: a case report

    Science.gov (United States)

    Katsinelos, Panagiotis; Pilpilidis, Ioannis; Katsinelos, Taxiarchis; Lazaraki, Georgia; Fasoulas, Kostas; Zavos, Christos; Kountouras, Jannis

    2009-01-01

    We report a young healthy woman, who believed that the consumption of large amounts of honeycomb would lead to good health and who finally developed a huge gastric bezoar of hard consistency. The conventional endoscopic techniques failed to manage the bezoar. Using the combination of injection of hydrogen peroxide 3% solution inside the bezoar to induce disintegration and a special designed needle-knife sphincterotome (bezotome) we managed to remove the bezoar in fragments. To the best of our knowledge this is the first reported bezoar caused by honeycomb. PMID:19829904

  10. A huge chondromyxoid fibroma of the nasal cavity in a newborn baby.

    Science.gov (United States)

    Yoo, Young Tae; Park, Joo Hyun; Sunwoo, Woong Sang; Rhee, Chae-Seo

    2012-08-01

    Chondromyxoid fibroma is a rare benign tumor that usually occurs in the long bones. A 2-month newborn presented with huge masses in the both nasal cavities, which turned out to be chondromyxoid fibroma. The masses originated from both inferior turbinates. Total turbinectomy on the left side and submucosal mass excision on the right side were performed. No recurrence or new lesion was observed during the 2 years of follow up. We report here on a rare case of nasal cavity chondromyxoid fibroma in a neonate and we review the relevant literature.

  11. Totally laparoscopic gastrectomy for early gastric cancer accompanied by huge hiatal hernia: A case report.

    Science.gov (United States)

    Hagiwara, Chie; Yajima, Kazuhito; Iwasaki, Yoshiaki; Oohinata, Ryouki; Yuu, Ken; Ishiyama, Satoshi; Amaki, Misato; Nakano, Daisuke; Yamaguchi, Tatsuro; Matsumoto, Hiroshi; Takahashi, Keiichi

    2016-02-01

    We herein present a case in which we used a totally laparoscopic approach for early gastric cancer accompanied by a huge hiatal hernia. An 80-year-old Japanese woman was referred with a chief complaint of dysphagia. A clinical diagnosis of early gastric cancer, T1b (SM) N0M0, stage IA, accompanied by hiatal hernia, was made. Distal gastrectomy with D1 plus lymphadenectomy was carried out. After the gastrectomy, the hernial sac was excised and the hernial orifice was closed. Reconstruction using the Roux-en-Y method was selected. The postoperative course was uneventful and she was discharged on postoperative day 10.

  12. Huge aneurysm and coronary-cameral fistula from right coronary branch: First case.

    Science.gov (United States)

    Ahmad, Tanveer; Pasarad, Ashwini Kumar; Kishore, Kolkebaile Sadanand; Maheshwarappa, Nandakumar Neralakere

    2016-02-01

    Coronary-cameral fistulas are rare cardiovascular anomalies. A giant coronary artery aneurysm associated with a coronary-cameral fistula is a very rare condition, with an estimated prevalence of 0.02%. We report the case of middle-aged woman who presented with a huge extracardiac aneurysmal mass and a coronary-cameral fistula from a right coronary artery branch. It was successfully repaired by ligation and excision plus marsupialization of the aneurysm. We believe this is the first such a case reported in literature.

  13. Design of a superluminal ring laser gyroscope using multilayer optical coatings with huge group delay.

    Science.gov (United States)

    Qu, Tianliang; Yang, Kaiyong; Han, Xiang; Wu, Suyong; Huang, Yun; Luo, Hui

    2014-01-01

    We propose and analyze a superluminal ring laser gyroscope (RLG) using multilayer optical coatings with huge group delay (GD). This GD assisted superluminal RLG can measure the absolute rotation with a giant sensitivity-enhancement factor of ~10(3); while, the broadband FWHM of the enhancement factor can reach 20 MHz. This superluminal RLG is based on a traditional RLG with minimal re-engineering, and beneficial for miniaturization according to theoretical calculation. The idea of using GD coatings as a fast-light medium will shed lights on the design and application of fast-light sensors.

  14. ESR1 Gene Polymorphisms and Prostate Cancer Risk: A HuGE Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Yu-Mei Wang

    Full Text Available Many published data on the association between single nucleotide polymorphisms (SNPs in the ESR1 gene and prostate cancer susceptibility are inconclusive. The aim of this Human Genome Epidemiology (HuGE review and meta-analysis is to derive a more precise estimation of this relationship.A literature search of PubMed, Embase, Web of Science and Chinese Biomedical (CBM databases was conducted from their inception through July 1st, 2012. Crude odds ratios (ORs with 95% confidence intervals (CIs were calculated to assess the strength of association.Twelve case-control studies were included with a total 2,165 prostate cancer cases and 3,361 healthy controls. When all the eligible studies were pooled into the meta-analysis, ESR1 PvuII (C>T and XbaI (A>G polymorphisms showed no association with the risk of prostate cancer. However, in the stratified analyses based on ethnicity and country, the results indicated that ESR1 PvuII (C>T polymorphism was significantly associated with increased risk of prostate cancer among Asian populations, especially among Indian population; while ESR1 XbaI (A>G polymorphism may significantly increase the risk of prostate cancer among American population. Furthermore, we also performed a pooled analysis for all eligible case-control studies to explore the role of codon 10 (T>C, codon 325 (C>G, codon 594 (G>A and +261G>C polymorphisms in prostate cancer risk. Nevertheless, no significant associations between these polymorphisms and the risk of prostate cancer were observed.Results from the current meta-analysis indicate that ESR1 PvuII (C>T polymorphism may be a risk factor for prostate cancer among Asian populations, especially among Indian population; while ESR1 XbaI (A>G polymorphism may increase the risk of prostate cancer among American population.

  15. Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review

    Directory of Open Access Journals (Sweden)

    Jeong S

    2016-02-01

    Full Text Available Sohyun Jeong, Jae Hyun Kim, Myeong Gyu Kim, Nayoung Han, In-Wha Kim, Therasa Kim, Jung Mi Oh College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea Background: CASR gene appears to be involved in cancer biology and physiology. However, a number of studies investigating CASR polymorphisms and cancer risks have presented inconclusive results. Thus, a systematic review and a meta-analysis of the effect of CASR polymorphisms on several cancer risks were performed to suggest a statistical evidence for the association of CASR polymorphisms with cancer risks.Methods: MEDLINE, EMBASE, Web of Science, Scopus, and the HuGE databases were searched. Nineteen articles of case–control and cohort studies were included for the final analysis.Results: The colorectal cancer risk was reduced in proximal (odds ratio [OR] =0.679, P=0.001 and distal (OR =0.753, P=0.026 colon sites with GG genotype of CASR rs1042636 and increased in distal colon site (OR =1.418, P=0.039 with GG genotype of rs1801726 by additive genetic model. The rs17251221 demonstrated noticeable associations that carrying a homozygote variant increases breast and prostate cancer risk considerably.Conclusion: The significant association of CASR polymorphisms with several cancer risks was observed in this review. In particular, the act of CASR polymorphisms as a tumor suppressor or an oncogene differs by cancer site and can be the research target for tumorigenesis. Keywords: rs1042636, rs1801725, rs1801726, systematic review, colorectal cancer

  16. An intelligent method for geographic Web search

    Science.gov (United States)

    Mei, Kun; Yuan, Ying

    2008-10-01

    While the electronically available information in the World-Wide Web is explosively growing and thus increasing, the difficulty to find relevant information is also increasing for search engine user. In this paper we discuss how to constrain web queries geographically. A number of search queries are associated with geographical locations, either explicitly or implicitly. Accurately and effectively detecting the locations where search queries are truly about has huge potential impact on increasing search relevance, bringing better targeted search results, and improving search user satisfaction. Our approach focus on both in the way geographic information is extracted from the web and, as far as we can tell, in the way it is integrated into query processing. This paper gives an overview of a spatially aware search engine for semantic querying of web document. It also illustrates algorithms for extracting location from web documents and query requests using the location ontologies to encode and reason about formal semantics of geographic web search. Based on a real-world scenario of tourism guide search, the application of our approach shows that the geographic information retrieval can be efficiently supported.

  17. Minimally Invasive Anterior Decompression Technique without Instrumented Fusion for Huge Ossification of the Posterior Longitudinal Ligament in the Thoracic Spine: Technical Note And Literature Review.

    Science.gov (United States)

    Yu, Jae Won; Yun, Sang-O; Hsieh, Chang-Sheng; Lee, Sang-Ho

    2017-09-01

    Several surgical methods have been reported for treatment of ossification of the posterior longitudinal ligament (OPLL) in the thoracic spine. Despite rapid innovation of instruments and techniques for spinal surgery, the postoperative outcomes are not always favorable. This article reports a minimally invasive anterior decompression technique without instrumented fusion, which was modified from the conventional procedure. The authors present 2 cases of huge beak-type OPLL. Patients underwent minimally invasive anterior decompression without fusion. This method created a space on the ventral side of the OPLL without violating global thoracic spinal stability. Via this space, the OPLL and anterior lateral side of the dural sac can be seen and manipulated directly. Then, total removal of the OPLL was accomplished. No orthosis was needed. In this article, we share our key technique and concepts for treatment of huge thoracic OPLL. Case 1. 51-year-old female was referred to our hospital with right lower limb radiating pain and paresis. Thoracic OPLL at T6-7 had been identified at our hospital, and conservative treatment had been tried without success. Case 2. This 54-year-old female with a 6-month history of progressive gait disturbance and bilateral lower extremity radiating pain (right>left) was admitted to our institute. She also had hypoesthesia in both lower legs. Her symptoms had been gradually progressing. Computed tomography scans showed massive OPLL at the T9-10 level. Magnetic resonance imaging of the thoracolumbar spine demonstrated ventral bony masses with severe anterior compression of the spinal cord at the same level. We used this surgical method in 2 patients with a huge beaked-type OPLL in the thoracic level. Complete removal of the OPLL via anterior decompression without instrumented fusion was accomplished. The 1st case had no intraoperative or postoperative complications, and the 2nd case had 1 intraoperative complication (dural tear) and no

  18. Search for antimatter and dark matter and precision studies of cosmic ray fluxes on the International Space Station. AMS experiment. Results of four-year exposure

    Science.gov (United States)

    Galaktionov, Yu V.

    2017-04-01

    The results of cosmic rays studies obtained in the AMS experiment in 2011-2015 on the International Space Station are discussed. Research on the energy spectra of electrons and positrons at TeV energies and precision measurements of fluxes were performed. The growth of the positron fraction with energy was observed. Proton and helium spectra were also obtained. A review of theoretical models with possible explanations of the observed phenomena is presented.

  19. Long-term survival after surgical resection for huge hepatocellular carcinoma: comparison with transarterial chemoembolization after propensity score matching.

    Science.gov (United States)

    Min, Yang Won; Lee, Jun Hee; Gwak, Geum-Youn; Paik, Yong Han; Lee, Joon Hyoek; Rhee, Poong-Lyul; Koh, Kwang Cheol; Paik, Seung Woon; Yoo, Byung Chul; Choi, Moon Seok

    2014-05-01

    Surgical resection (SR) and transarterial chemoembolization (TACE) have been commonly applied for patients with huge hepatocellular carcinoma (HCC). However, optimal treatment has not been established. Between 2000 and 2009, 267 patients with huge HCC (≥ 10 cm) underwent TACE and 84 underwent SR as the first treatment. Propensity score matching generated a matched cohort composed of 152 patients. We investigated overall survival and possible prognostic factors. At baseline, the surgery group showed a tendency to have solitary tumor (72.6% vs 39.3%, P huge HCC. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  20. Autonomous search

    CERN Document Server

    Hamadi, Youssef; Saubion, Frédéric

    2012-01-01

    Autonomous combinatorial search (AS) represents a new field in combinatorial problem solving. Its major standpoint and originality is that it considers that problem solvers must be capable of self-improvement operations. This is the first book dedicated to AS.

  1. Dark matter searches at the LHC

    CERN Document Server

    Hong, Tae Min; The ATLAS collaboration

    2017-01-01

    We present a summary of the current status of searches for dark matter at the LHC from the ATLAS and CMS experiments. For various assumptions in the simplified parameter space, the LHC exclusions is complementary to direct detection results. Mono-object analyses in search of dark matter and various analyses searching for dark matter mediators are presented.

  2. A huge 6.2 kilogram uterine myoma coinciding with omental leiomyosarcoma: case report.

    Science.gov (United States)

    Ruan, C W; Lee, C L; Yen, C F; Wang, C J; Soong, Y K

    1999-12-01

    Surgery for massive abdominal tumors is both interesting and challenging. We present a case involving a multiple uterine myoma weighing 6.2 Kg which coincided with omental leiomyosarcoma. To our knowledge, this is the first report of this type of condition in the English literature. A 44-year-old nulliparous woman had suffered from abdominal pain for a long time. A huge abdominal mass was palpated on physical examination. Computed tomography scanning revealed a huge pelvic-abdominal mass with the possibility of small bowel loops invaded by the mass. A 6-cm omental mass was incidentally found during the subsequent hysterectomy procedure. Perforation of the urinary bladder occurred during the dissection of adhesion. Resection of the omental mass, wide wedge resection of the invaded small bowel, primary repair of the bladder, and hysterectomy were performed. The final pathologic diagnosis was uterine leiomyomata with omental leiomyosarcoma. The patient returned home on postoperative day 14 and was well at the 18-month follow-up examination. The challenge of these tumors lies in their proper diagnosis and surgical management. More case reports and follow-up studies are needed to confirm the efficacy of their management.

  3. Treatment of Huge Hepatocellular Carcinoma Using Cinobufacini Injection in Transarterial Chemoembolization: A Retrospective Study

    Directory of Open Access Journals (Sweden)

    Jun Dong

    2016-01-01

    Full Text Available The aim of this study is to examine the safety and efficacy of Cinobufacini injection in transarterial chemoembolization (TACE for treatment of huge hepatocellular carcinoma (HCC. Clinical data of 56 consecutive patients with HCC larger than 10 cm who had been treated with TACE between December 2010 and August 2014 were retrospectively analyzed. Among these patients, 31 belonged to the Cinobufacini group and 25 belonged to the epirubicin group. The clinical efficacy, survival time, and adverse events in patients in the two groups were compared. The objective response rate in the Cinobufacini group was significantly higher than that in the epirubicin group (53.6% versus 23.1%, P=0.022. The median survival time (10.6 versus 14.1 months, χ2=0.092, P=0.762 and the median time to progression (4.9 versus 5.7 months, χ2=0.097, P=0.756 were similar between the groups. The incidence rate of adverse events was lower in the Cinobufacini group than in the epirubicin group (P<0.05. The short-term clinical efficacy of Cinobufacini is better than that of epirubicin in TACE for treating huge HCC, while their long-term clinical efficacy is similar. However, lower incidence of adverse events was noted in TACE using Cinobufacini rather than epirubicin.

  4. Surgical resection of a huge cemento-ossifying fibroma in skull base by intraoral approach.

    Science.gov (United States)

    Cheng, Xiao-Bing; Li, Yun-Peng; Lei, De-Lin; Li, Xiao-Dong; Tian, Lei

    2011-03-01

    Cemento-ossifying fibroma, also known as ossifying fibroma, usually occurs in the mandible and less commonly in the maxilla. The huge example in the skull base is even rare. We present a case of a huge cemento-ossifying fibroma arising below the skull base of a 30-year-old woman patient. Radiologic investigations showed a giant, lobulated, heterogeneous calcified hard tissue mass, which is well circumscribed and is a mixture of radiolucent and radiopaque, situated at the rear of the right maxilla to the middle skull base. The tumor expands into the right maxillary sinus and the orbital cavity, fusing with the right maxilla at the maxillary tuberosity and blocking the bilateral choanas, which caused marked proptosis and blurred vision. The tumor was resected successfully by intraoral approach, and pathologic examination confirmed the lesion to be a cemento-ossifying fibroma. This case demonstrates that cemento-ossifying fibroma in the maxilla, not like in the mandible, may appear more aggressive because the extensive growth is unimpeded by anatomic obstacles and that the intraoral approach can be used to excise the tumor in the skull base.

  5. The technical research on the huge glazed brick from the relic of Nanyue Kingdom Palace

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    'Qin brick and Han tile' has a great worldwide reputation in the architectural history of China. According to the former archaeological materials, the big hollow brick is usually one meter long and thirty to forty centimeters wide, while the solid brick is generally much smaller. But in 1995, large scale vestiges and structures were unearthed at the center of Guangzhou's old district, from the relic of Nanyue Kingdom Palace, which was built some 2000 years ago during the Western-Han Dynasty, A great number of earthen structural members were discovered, especially the solid glazed bricks in various beautiful patterns with an astonishing thickness and size. Some of them are one meter square, more than 20 centimeters thick, and weight half a ton, which are named ‘Brick No.1 in the world' by excavators. People have shown great interest in how to make these huge glazed bricks at the ancient technical conditions, because it is very difficult to manufacture such huge bricks even with the modern technology. At the request of Guangdong Nanyue Kingdom Palace Museum, Shanghai Institute of Ceramics carried out systematical measurements and analysis on these bricks and studied the physical and chemical forming mechanisms from their chemical compositions, structure, and physical characteristics. Here the technical characteristics of the bricks are also discussed.

  6. The technical research on the huge glazed brick from the relic of Nanyue Kingdom Palace

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    ‘Qin brick and Han tile’ has a great worldwide reputation in the architectural history of China. According to the former archaeological materials, the big hollow brick is usually one meter long and thirty to forty centimeters wide, while the solid brick is generally much smaller. But in 1995, large scale vestiges and structures were un- earthed at the center of Guangzhou’s old district, from the relic of Nanyue Kingdom Palace, which was built some 2000 years ago during the Western-Han Dynasty. A great number of earthen structural members were discovered, especially the solid glazed bricks in various beautiful patterns with an astonishing thickness and size. Some of them are one meter square, more than 20 centimeters thick, and weight half a ton, which are named ‘Brick No.1 in the world’ by excavators. People have shown great interest in how to make these huge glazed bricks at the ancient tech- nical conditions, because it is very difficult to manufacture such huge bricks even with the modern technology. At the request of Guangdong Nanyue Kingdom Palace Museum, Shanghai Institute of Ceramics carried out systematical measurements and analysis on these bricks and studied the physical and chemical forming mechanisms from their chemical compositions, structure, and physical character- istics. Here the technical characteristics of the bricks are also discussed.

  7. Treatment of Huge Hepatocellular Carcinoma Using Cinobufacini Injection in Transarterial Chemoembolization: A Retrospective Study.

    Science.gov (United States)

    Dong, Jun; Zhai, Xiaofeng; Chen, Zhe; Liu, Qun; Ye, Hua; Chen, Wei; Ling, Changquan

    2016-01-01

    The aim of this study is to examine the safety and efficacy of Cinobufacini injection in transarterial chemoembolization (TACE) for treatment of huge hepatocellular carcinoma (HCC). Clinical data of 56 consecutive patients with HCC larger than 10 cm who had been treated with TACE between December 2010 and August 2014 were retrospectively analyzed. Among these patients, 31 belonged to the Cinobufacini group and 25 belonged to the epirubicin group. The clinical efficacy, survival time, and adverse events in patients in the two groups were compared. The objective response rate in the Cinobufacini group was significantly higher than that in the epirubicin group (53.6% versus 23.1%, P = 0.022). The median survival time (10.6 versus 14.1 months, χ (2) = 0.092, P = 0.762) and the median time to progression (4.9 versus 5.7 months, χ (2) = 0.097, P = 0.756) were similar between the groups. The incidence rate of adverse events was lower in the Cinobufacini group than in the epirubicin group (P huge HCC, while their long-term clinical efficacy is similar. However, lower incidence of adverse events was noted in TACE using Cinobufacini rather than epirubicin.

  8. Addressing huge spatial heterogeneity induced by virus infections in lentil breeding trials.

    Science.gov (United States)

    Kargiotidou, Anastasia; Vlachostergios, Dimitrios N; Tzantarmas, Constantinos; Mylonas, Ioannis; Foti, Chrysanthi; Menexes, George; Polidoros, Alexios; Tokatlidis, Ioannis S

    2016-12-01

    Spatial heterogeneity can have serious effects on the precision of field experimentation in plant breeding. In the present study the capacity of the honeycomb design (HD) to sample huge spatial heterogeneity was appraised. For this purpose, four trials were conducted each comprising a lentil landrace being screened for response to viruses. Huge spatial heterogeneity was reflected by the abnormally high values for coefficient of variation (CV) of single-plant yields, ranging 123-162 %. At a given field area, increasing the number of simulated entries was followed by declined effectiveness of the method, on account of the larger circular block implying greater intra-block heterogeneity; a hyperbolic increasing pattern of the top to bottom entry mean gap (TBG) indicated that a number of more than 100 replicates (number of plants per entry) is the crucial threshold to avoid significant deterioration of the sampling degree. Nevertheless, the honeycomb model kept dealing with variation better than the randomized complete block (RCB) pattern, thanks to the circular shape and standardized type of block that ensure the less possible extra heterogeneity with expanding the area of the block. Owing to the even and systematic entry allocation, breeders do not need to be concerned with the extra spatial heterogeneity that might induce the extra surface needed to expand the size of the block when many entries are considered. Instead, they could improve accuracy of comparisons with increasing the number of replicates (circular blocks) despite the concomitant greater overall spatial heterogeneity.

  9. Challenging the time complexity of exact subgraph isomorphism for huge and dense graphs with VF3.

    Science.gov (United States)

    Carletti, Vincenzo; Foggia, Pasquale; Saggese, Alessia; Vento, Mario

    2017-04-24

    Graph matching is essential in several fields that use structured information, such as biology, chemistry, social networks, knowledge management, document analysis and others. Except for special classes of graphs, graph matching has in the worst-case an exponential complexity; however, there are algorithms that show an acceptable execution time, as long as the graphs are not too large and not too dense. In this paper we introduce a novel subgraph isomorphism algorithm, VF3, particularly efficient in the challenging case of graphs with thousands of nodes and a high edge density. Its performance, both in terms of time and memory, has been assessed on a large dataset of 12700 random graphs with a size up to 10000 nodes, made publicly available. VF3 has been compared with four other state-of-the-art algorithms, and the huge experimentation required more than two years of processing time. The results confirm that VF3 definitely outperforms the other algorithms when the graphs become huge and dense, but also has a very good performance on smaller or sparser graphs.

  10. Strontium-89 therapy for the treatment of huge osseous metastases in prostate carcinoma: A case report.

    Science.gov (United States)

    Zhang, Wenjie; Zhao, Weiwei; Jia, Zhiyun; Deng, Houfu

    2013-02-01

    Prostate cancer is a growing public health problem. The palliation of pain in patients with painful bone metastases is of primary importance in the clinical management of advanced cancer. Internal therapy with radionuclides, which concentrate at sites of increased bone turnover, is used to control pain and improve quality of life as an alternative to conventional therapies. In the present study, we report the case of a 52-year-old male who had been diagnosed with prostate cancer. The patient presented with severe pain in multiple areas, but particularly in the right hip. A whole-body bone scan revealed that the right hip, ilium and ischium were covered with huge metastatic lesions. Treatment with radionuclide strontium-89 chloride ((89)Sr) resulted in a partial response which was confirmed by the successful relief of pain and other imaging modalities. No significant change in the leukocyte or thrombocyte levels was observed. The results of the present study indicate that systemic radionuclide therapy using (89)Sr is an effective, well-tolerated and safe palliative treatment in patients with huge osseous metastases in prostate carcinoma.

  11. Resection of Huge Liver Cancer Involving the Second Porta Hepatis:A Report of 55 Cases

    Institute of Scientific and Technical Information of China (English)

    CHENHan; WUMengchao; WANGYi; WEIGongtian; HULei

    2002-01-01

    Objective To investigate the possibility and surgical procedures for huge liver cancer involving the second porta hepatis.Methods 55 cases of huge liver cancer, with the diameter of 8-28 cm(mean 12.7 cm) were studied. Right subcostal or “rooftop” incision was made, the liver ligments were divided, good exposure of the tumor and access to retrohepatic inferior vena cava were achieved.Hepatectomies were completed under intermittent interruption of first porta hepatis. Occluding tape around vena cava was applied before liver resection if necessary.Results All tumors were successfully resected without death during operation.The longest survival time was now 4 years in one case. The 1-4 year postoperative survival rates were 63%,50%,50% and 30% respectively.Conclusion Young patients with solitary large liver tumor, which grows slowly over a long period on basis of non-cirrhotic or mild cirrhotic liver, should undergo an exploration in an attempt of resection irrespective of the image contraindication, provided that there is no extra-hepatic metastasis.

  12. [One case of huge cyst at the back end of nasal septum].

    Science.gov (United States)

    Zang, Jian; Liu, Qian; Jiang, Xuejun

    2014-04-01

    A male of 17 years old complained of bilateral nasal congestion with mouth breathing for half a year. The physical examination showed patency of bilateral nasal cavity. Nasopharyngeal fiberscope revealed a huge spherical smooth reddish mass at the nasopharyngeal posterior wall and the back-end of nasal cavity blocking the entire postnaris and contacting with bilateral tubal tori, the size of which is about 3.5 cm x 2.5 cm. The nasopharyngeal 3D-CT showed a low density cystic mass area in the nasopharynx with smooth edges, and the CT value is approximately 32.4 HU. No exact enhancement was observed. The cystic mass originated from and compressed the back end of nasal septum. A semicircular defect in the leading edge of clivus was observed, and the inferior wall of sphenoid sinus is compressed uplifted upwards. The nasopharyngeal MR showed that the nasopharyngeal lesion presented short T1 and long T2 signals with multiple small wall nodules around. Neither the lesion nor the peripheral nodules can be significantly enhanced by enhancement scan. After a nasal endoscopic surgery, the case was definitely diagnosed as nasal septum back-end huge cyst.

  13. [Development of domain specific search engines].

    Science.gov (United States)

    Takai, T; Tokunaga, M; Maeda, K; Kaminuma, T

    2000-01-01

    As cyber space exploding in a pace that nobody has ever imagined, it becomes very important to search cyber space efficiently and effectively. One solution to this problem is search engines. Already a lot of commercial search engines have been put on the market. However these search engines respond with such cumbersome results that domain specific experts can not tolerate. Using a dedicate hardware and a commercial software called OpenText, we have tried to develop several domain specific search engines. These engines are for our institute's Web contents, drugs, chemical safety, endocrine disruptors, and emergent response for chemical hazard. These engines have been on our Web site for testing.

  14. Biased Predecessor Search

    DEFF Research Database (Denmark)

    Bose, Prosenjit; Fagerberg, Rolf; Howat, John

    2016-01-01

    We consider the problem of performing predecessor searches in a bounded universe while achieving query times that depend on the distribution of queries. We obtain several data structures with various properties: in particular, we give data structures that achieve expected query times logarithmic...... in the entropy of the distribution of queries but with space bounded in terms of universe size, as well as data structures that use only linear space but with query times that are higher (but still sublinear) functions of the entropy. For these structures, the distribution is assumed to be known. We also...

  15. Model-based online optimisation of modern internal combustion engines. Part 2: Limits of the feasible search space; Modellbasierte Online-Optimierung moderner Verbrennungsmotoren. Teil 2: Grenzen des fahrbaren Suchraums

    Energy Technology Data Exchange (ETDEWEB)

    Knoedler, K.; Poland, J.; Zell, A. [Univ. Tuebingen (Germany). Lehrstuhl fuer Rechnerarchitektur; Fleischhauer, T.; Mitterer, A.; Ullmann, S. [BMW Group (Germany)

    2003-06-01

    The first part of this two-part article introduced the basis of the mbminimize algorithm, which was developed by the University of Tuebingen in cooperation with the BMW Group for the model-based online optimisation of internal combustion engines. This second part describes it extensions regarding the handling of engine limits such as knocking. The main focus is on the construction of special mathematical models for these limits that make it possible to successively and controllably restrict the search space. (orig.) [German] Der erste Teil dieses zweiteiligen Beitrags stellte die Basis des mbminimize-Algorithmus vor, der von der Universitaet Tuebingen in Zusammenarbeit mit der BMW Group zur modellbasierten Online-Optimierung von Verbrennungsmotoren entwickelt wurde. Der vorliegende Artikel beschreibt die Erweiterungen hinsichtlich der Behandlung von Motorlimits wie zum Beispiel Motorklopfen. Den Schwerpunkt stellen Modelle fuer Motorlimits dar, die es erlauben, den Suchraum sukzessive und kontrollierbar einzuschraenken. (orig.)

  16. Research of individuation search engine based on the improved vector space model%基于改进向量空间模型的个性化搜索引擎研究

    Institute of Scientific and Technical Information of China (English)

    姬睿

    2015-01-01

    研究移动搜索引擎中的个性化搜索服务。在用户兴趣建模的过程中,采用改进的向量空间模型,通过非线性函数处理特征项词频的方法,改进页面特征项权值的计算。改进的特征项权值计算公式。同时考虑标题中特征项的重要性,并利用非线性函数处理特征项出现的频率,使权值的计算更加准确。实验结果表明,改进后的用户兴趣模型使网页检索的查准率和召回率都有了较好的改善,有效地提高了搜索引擎的性能,能够满足用户的个性化需求。%T he personalized search service of mobile search engine is studied .T he improved vec‐tor space model is used in user interest modeling .And page feature item weight calculation is improved by processing word frequency of feature item with nonlinear function .Improved fea‐ture item weight calculation ,as well as the importance of the title of the feature items ,and the use of the frequency characteristics of the nonlinear function processing items make the calcula‐tion more accurate .Experimental results show that the improved user interest model makes web retrieval precise and recall rate improved ,effectively enhancing the performance of the search engine ;it is thus possible to meet the individual needs of users .

  17. Search for TeV-Antiprotons in Space from the Shadowing of Cosmic Rays by the Moon with the L3+C Detector

    CERN Document Server

    Xu, Yupeng

    2005-01-01

    A search for antiprotons in the primary cosmic ray flux has been performed by observing the Moon shadow with the muon data collected by the L3+C experiment at CERN during 1999 and 2000. The angular resolution of the detector and its dependences on the muon energy and zenith angle are obtained at the event level with a Monte Carlo simulation and the analysis of real double muon data using a maximum likelihood method. The Moon shadow effect is observed in three muon momentum bands > 100GeV/c, 65 - 100 GeV/c and 30 - 65 GeV/c with a significance of 7.0 cr, 5.8 cr and 5.2 cr respectively. Two dimensional maximum likelihood analyses are performed, both with binned data and unbinned data. The unbinned method gives a smaller uncertainty on the measurement of the antiproton to proton ratio. For a muon momentum cut at 70 GeV/c, the antiproton to proton ratio is measured to be -0.12 + 0.11 and an upper limit of this ratio is estimated to be 0.08 (at 90% confidence level) for primary energies in the range 0.8 TeV to 2.4...

  18. The HUGE formula (hematocrit, urea, gender) for screening for chronic kidney disease in elderly patients: a study of diagnostic accuracy.

    Science.gov (United States)

    Musso, Carlos G; de Los Rios, Eduardo; Vilas, Manuel; Terrasa, Sergio; Bratti, Griselda; Varela, Federico; Diez, Guillermo Rosa; Jauregui, Jose; Luna, Daniel

    2017-04-01

    Chronically reduced glomerular filtration rate (GFR) in old people does not always mean that they suffer from chronic kidney disease (CKD) since their GFR can just be reduced by aging. The HUGE equation has been recently described and validated in Spain for screening CKD without taking into account the patient's GFR value. This equation is based on patient's hematocrit, plasma urea levels and gender. The present study documented that the HUGE equation had and acceptable performance for screening CKD in elderly Argentine patients.

  19. 巨大阑尾黏液性囊腺瘤1例%1 case of huge appendiceal mucinous cystadenoma

    Institute of Scientific and Technical Information of China (English)

    王磊; 刘雯雯

    2016-01-01

    Huge appendiceal mucinous cystadenoma is rare in clinic,and the preoperative misdiagnosis rate is high.The data of 1 case of huge appendiceal mucinous cystadenoma was introduced in this paper.%巨大阑尾黏液性囊腺瘤临床较少见,术前误诊率高。本文对巨大阑尾黏液性囊腺瘤1例的病例资料进行介绍。

  20. Huge hepatocellular carcinoma greater than 10 cm in diameter worsens prognosis by causing distant recurrence after curative resection.

    Science.gov (United States)

    Wakayama, Kenji; Kamiyama, Toshiya; Yokoo, Hideki; Orimo, Tatsuya; Shimada, Shingo; Einama, Takahiro; Kamachi, Hirofumi; Taketomi, Akinobu

    2017-03-01

    This study aimed to evaluate the impact of huge (≥10 cm) hepatocellular carcinoma (HCC) to the recurrence pattern and the prognosis after hepatectomy. 574 patients who underwent hepatectomy by 17 surgeons (Open 536 and Laparoscopic 38) for HCC without major vascular invasion from 1990 to 2013 at single institute were retrospectively analyzed. Huge tumor, age, HCV, multiple tumors and microscopic portal invasion are independent risk factors for overall survival (OS), and huge tumor, ICGR15 ≥16%, multiple tumors, moderate/poor histology, microscopic portal invasion and a positive pathological margin are risk factors for relapse-free survival (RFS). The 5-year OS and RFS of patients with huge HCC (n = 53) (42.9 and 14.2%) were significantly worse than those of patients with HCC Huge tumor is an independent risk factor for initial extra-hepatic recurrence (Hazard ratio 7.86, P Huge HCC (≥10 cm) is an independent risk factor due to a high risk for initial extra-hepatic recurrence. Future systemic adjuvant therapy is needed for these patients. J. Surg. Oncol. 2017;115:324-329. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  1. $A$ searches

    CERN Document Server

    Beacham, James

    The Standard Model of particle physics encompasses three of the four known fundamental forces of nature, and has remarkably withstood all of the experimental tests of its predictions, a fact solidified by the discovery, in 2012, of the Higgs boson. However, it cannot be the complete picture. Many measurements have been made that hint at physics beyond the Standard Model, and the main task of the high- energy experimental physics community is to conduct searches for new physics in as many di↵erent places and regimes as possible. I present three searches for new phenomena in three di↵erent high-energy collider experiments, namely, a search for events with at least three photons in the final state, which is sensitive to an exotic decay of a Higgs boson into four photons via intermediate pseudoscalar particles, a, with ATLAS, at the Large Hadron Collider; a search for a dark photon, also known as an A0 , with APEX, at Thomas Je↵erson National Accelerator Facility; and a search for a Higgs decaying into four...

  2. Treatment of huge hypertensive putaminal hemorrhage by surgery and cerebrospinal fluid drainage.

    Science.gov (United States)

    Zhang, Hong-Tian; Xue, Sha; Li, Pei-Jian; Fu, Yan-Bin; Xu, Ru-Xiang

    2013-09-01

    There is limited information available regarding the treatment of huge hypertensive putaminal hemorrhage (HPH). This study aimed to evaluate our experience of 33 patients with huge HPH who were treated by open surgery (decompressive craniectomy and hematoma evacuation) and external cerebrospinal fluid (CSF) drainage. We reviewed the records of 33 consecutive patients admitted to our hospital with huge HPH (≥ 60 cm(3)). All patients were treated by decompressive craniectomy, hematoma evacuation, and CSF drainage. Data collected included age, gender, blood pressure at admission, Glasgow Coma Scale (GCS) score, intracranial hemorrhage (ICH) location, ICH volume, degree of midline shift, presence/absence of basal cistern obliteration at admission and before surgery, and presence/absence of intraventricular hemorrhage (IVH). Outcome was assessed by the Glasgow Outcome Scale score at 30 days after surgery. The median GCS score was 5.0 at admission, and improved to 8.0 at 1 week after surgery. The median ICH volume was 95 cm(3) before surgery and 4 cm(3) after surgery. IVH was observed in 93.9% of patients. The overall survival rate to discharge was 75.6% (25/33), including 15.1% (4/33) with good function, 36.4% (12/33) with disability, and 24.3% (8/33) in a vegetative state. The mortality rate was 24.3% (8/33). Patients with right-sided ICH had better outcomes than those with left-sided ICH. No patients with GCS score ≤ 6 and ICH volume ≥ 90cm(3) at admission achieved good postoperative function. Operative time was significantly shorter with hematoma evacuation via the transcortical approach than via the transsylvian approach (3.41 ± 0.75 h vs. 4.14 ± 0.59 h, Phuge HPH by decompressive craniectomy, hematoma evacuation, and CSF drainage is life-saving. Patients with GCS score 7-8, ICH volume 60-90 cm(3), and right-sided ICH may achieve good recovery. The transcortical approach appears to be more effective than the transsylvian approach for rapid decompression of

  3. Cosmic Ray Monitoring and Space Dangerous Phenomena, 1. Search of Features In Cosmic Rays What Can Be Used For Forecasting of Major Geomagnetic Storms

    Science.gov (United States)

    Dorman, L. I.; Pustil'Nik, L. A.; Sternlieb, A.; Zukerman, I. G.

    According to NOAA Space Weather Scales, geomagnetic storms of scales G5 (3- hour index of geomagnetic activity Kp=9), G4 (Kp=8) and G3 (Kp=7) are dangerous for people technology and health (influence on power systems, on spacecraft oper- ations, on HF radio-communications and others). To prevent these serious damages will be very important to forecast dangerous geomagnetic storms. In many papers it was shown that in principle for this forecasting can be used data on CR intensity and CR anisotropy changing before SC of major geomagnetic storms accompanied by sufficient Forbush-decreases (e.g., Dorman et al., 1995, 1999). In this paper we con- sider over 100 major geomagnetic storms and for each case we analyze hourly data of many NM for 8 days with SC in the 4-st day of 8-days period (that before SC we have at least 3 full days). We determine what part of major geomagnetic storms is accompanied CR intensity and CR anisotropy changing before SC, and what part of major geomagnetic storms does not show any features what can be used for forecast- ing. We estimate also how these parts depend from the index of geomagnetic activ- ity Kp. REFERENCES: Dorman L.I., et al. "Cosmic-ray forecasting features for big Forbush-decreases". Nuclear Physics B, Vol. 49A, pp. 136-144. (1995). L.I.Dorman, et al, "Cosmic ray Forbush-decrease as indicators of space dangerous phenomenon and possible use of cosmic ray data for their prediction", Proc. of 26-th Intern. Cos- mic Ray Conference, Salt Lake City, Vol. 6, p. 476-479, (1999).

  4. Huge pelvic parachordoma: fine needle aspiration cytology and histological differential diagnosis

    Directory of Open Access Journals (Sweden)

    Mona A. Kandil

    2012-10-01

    Full Text Available Parachordoma is an extremely rare soft tissue tumor of unknown lineage. Parachordoma develops most often on the extremities. Only 2 cases have been reported as pelvic parachordoma. A 46-year old Egyptian woman with a huge painful pelvic mass was found to have a parachordoma with ectopic pelvic right kidney. There is only one report in the literature of fine needle aspiration cytology in this setting. The microscopic picture of parachordoma is not new to pathologists but the gross picture of this rare tumor has not previously been published; not even in the World Health Organization classification of soft tissues tumors. Diagnosis was confirmed by immuno-histochemistry. The patient is in good clinical condition without any evidence of recurrence or metastasis after 84 months of follow up.

  5. Shape Memory and Huge Superelasticity in Ni–Mn–Ga Glass-Coated Fibers

    Directory of Open Access Journals (Sweden)

    Lei Shao

    2017-01-01

    Full Text Available Ni–Mn–Ga polycrystalline alloy fibers with diameters of 33 μm are reported to exhibit significantly improved ductility and huge superelastic and shape memory strains in comparison to conventional brittle bulk polycrystalline alloys. Particularly, the recoverable strain of the Ni54.9–Mn23.5–Ga21.6 fiber can be as high as 10% at 40 °C. Such optimized behavior has been achieved by a suitable fabrication process via a glass-coating melt spinning method. The superelastic properties at different temperatures and the shape memory effect of Ni54.9–Mn23.5–Ga21.6 fibers were investigated.

  6. Tiny grains give huge gains: nanocrystal-based signal amplification for biomolecule detection.

    Science.gov (United States)

    Tong, Sheng; Ren, Binbin; Zheng, Zhilan; Shen, Han; Bao, Gang

    2013-06-25

    Nanocrystals, despite their tiny sizes, contain thousands to millions of atoms. Here we show that the large number of atoms packed in each metallic nanocrystal can provide a huge gain in signal amplification for biomolecule detection. We have devised a highly sensitive, linear amplification scheme by integrating the dissolution of bound nanocrystals and metal-induced stoichiometric chromogenesis, and demonstrated that signal amplification is fully defined by the size and atom density of nanocrystals, which can be optimized through well-controlled nanocrystal synthesis. Further, the rich library of chromogenic reactions allows implementation of this scheme in various assay formats, as demonstrated by the iron oxide nanoparticle linked immunosorbent assay (ILISA) and blotting assay developed in this study. Our results indicate that, owing to the inherent simplicity, high sensitivity and repeatability, the nanocrystal based amplification scheme can significantly improve biomolecule quantification in both laboratory research and clinical diagnostics. This novel method adds a new dimension to current nanoparticle-based bioassays.

  7. Development of a huge varix following endovascular embolization for cerebellar arteriovenous malformation

    Energy Technology Data Exchange (ETDEWEB)

    Mineura, K.; Sasajima, H.; Itoh, Y.; Kowada, M. [Akita Univ. Hospital (Japan). Neurosurgical Service; Tomura, N. [Akita Univ. Hospital (Japan). Dept. of Radiology; Goto, K. [Iizuka Hospital, Fukuoka (Japan). Dept. of Interventional Neuroradiology

    1998-03-01

    We report on the case of a huge varix that developed after the endovascular embolization of a cerebellar arteriovenous malformation (AVM) with a single drainer. A 21-year-old male presented with trigeminal neuralgia which was caused by the dilated drainer of the AVM. A varix was found at the basal vein of Rosenthal 2 months after an initial stage of embolization with polyvinyl alcohol particles; it diminished after the surgical extirpation of the AVM. The varix formation might have been facilitated by the stenosis in the vein of Galen and by the dynamic changes that followed the embolization. This rare complication should be kept in mind when embolization is performed for AVMs with impaired venous outlets. (orig.).

  8. Huge spin-transfer torque in a magnetic tunnel junction by a superlattice barrier

    Science.gov (United States)

    Chen, C. H.; Tseng, P.; Ko, C. W.; Hsueh, W. J.

    2017-09-01

    Huge spin-transfer torque (STT) in a magnetic tunnel junction (MTJ) achieved by superlattice barrier composed of alternate layers of a nonmagnetic metal and an insulator is proposed. The magnitude of the STT depends on the number of cells in the superlattice barrier and the nonmagnetic metal layer's thickness. The result shows that the STT of the novel superlattice-barrier MTJ can reach values up to four orders of magnitude greater than those of traditional single-barrier stacks based on three cells superlattice by designing the nonmagnetic metal layer's thickness. In addition, the spin-transfer torque of the proposed MTJ can also be thousands of magnitude greater than those of traditional double-barrier MTJs.

  9. Unusual Large Sporadic Angiomyolipoma Co-existing with Huge Simple Renal Cyst

    Directory of Open Access Journals (Sweden)

    Sunil V Jagtap

    2011-07-01

    Full Text Available Renal Angiomyolipoma (AML is an unusual benign mesenchymal tumor with no malignant potential. It is composed of adipose tissue, smooth muscle and abnormal thick walled blood vessels. It can occur sporadically or may be associated with tuberous sclerosis. Sporadic angiomyolipoma (AML coexisting with simple renal cyst is extremely rare and only one case report is available in the literature. In our case, unique combination of sporadic AML along with simple renal cyst with huge size and weight was noted. To the best of our knowledge, ours is the second such case and first case from India. Due to its large size, complete nephrectomy was performed to avoid chances of rupture and retroperitoneal hemorrhage. Post-operative period was uneventful and the patient ahs been on regular follow-up.

  10. Bilateral ureteral complete obstruction with huge spontaneous urinoma formation in a patient with advanced bladder cancer.

    Science.gov (United States)

    Jou, Yeong-Chin; Shen, Cheng-Huang; Cheng, Ming-Chin; Lin, Chang-Te; Chen, Pi-Che

    2012-02-01

    Spontaneous rupture of the collecting system with extravasation of urine and urinoma formation is usually associated with urinary tract obstruction by a ureteral calculus. Tumor growth is an extremely rare cause of urinary extravasation. Here we report a case of bilateral obstructive uropathy with a huge spontaneous left retroperitoneal urinoma caused by advanced infiltrative transitional cell carcinoma of the urinary bladder. The point of leakage was located in the left renal pelvis. The urinary leakage ceased after percutaneous nephrostomy drainage, and the patient subsequently underwent radical cystoprostatectomy. Histopathology revealed a high-grade urothelial carcinoma of the urinary bladder with pelvic lymph node metastasis. The patient refused any adjuvant treatment and expired 6 months after the operation from disseminated metastasis from bladder cancer. Copyright © 2011. Published by Elsevier B.V.

  11. Bilateral ureteral complete obstruction with huge spontaneous urinoma formation in a patient with advanced bladder cancer

    Directory of Open Access Journals (Sweden)

    Yeong-Chin Jou

    2012-02-01

    Full Text Available Spontaneous rupture of the collecting system with extravasation of urine and urinoma formation is usually associated with urinary tract obstruction by a ureteral calculus. Tumor growth is an extremely rare cause of urinary extravasation. Here we report a case of bilateral obstructive uropathy with a huge spontaneous left retroperitoneal urinoma caused by advanced infiltrative transitional cell carcinoma of the urinary bladder. The point of leakage was located in the left renal pelvis. The urinary leakage ceased after percutaneous nephrostomy drainage, and the patient subsequently underwent radical cystoprostatectomy. Histopathology revealed a high-grade urothelial carcinoma of the urinary bladder with pelvic lymph node metastasis. The patient refused any adjuvant treatment and expired 6 months after the operation from disseminated metastasis from bladder cancer.

  12. Huge epithelial nonparasitic splenic cyst: A case report and a review of treatment methods.

    Science.gov (United States)

    Farhangi, Bahman; Farhangi, Arezo; Firouzjahi, Alireza; Jahed, Babak

    2016-01-01

    Splenic cysts are rare in all age groups and there are a few reports in the world literature. Primary cysts occur most frequently in children and young adults, comprising around 25% of all nonparasitic splenic cysts. Various techniques are suggested for the treatment of splenic cysts. In this case report, a huge epithelial splenic cyst in a 17-year-old female is presented and different treatment methods of splenic cysts are evaluated. A 17-year-old female presented with progressive abdominal mass in left upper quadrant associated with abdominal pain and food intolerance of duration of several months. There was no history of trauma. On physical examination, there was a huge mass located in the upper left side of abdomen. Computerized tomography scan revealed that a large cystic lesion had occupied the spleen with dimensions of 32x21xI5.6 cm. After patient preparation laparotomy was performed and complete cyst excision was done with splenectomy, patient was discharged after 2 days. This is a report of a case of epithelial splenic cyst of the spleen in a 17-year old female. The management of splenic cysts continues to evolve and the optimum treatment of patients with nonparasitic splenic cysts is controversial, as a principle preservation technique of the spleen with minimally invasive methods such as laparoscopy is preferred to splenectomy with the exception of very large cysts and when splenic hilum is involved in cyst wall. However, significant cyst recurrences were encountered with these techniques. Recently open partial splenectomy has been proposed as a safe and effective method in the management of NPSCs it ensures complete cyst removal, lack of cyst recurrence, and preservation of the spleen functions.

  13. Bioinspired oil strider floating at the oil/water interface supported by huge superoleophobic force.

    Science.gov (United States)

    Liu, Xueli; Gao, Jun; Xue, Zhongxin; Chen, Li; Lin, Ling; Jiang, Lei; Wang, Shutao

    2012-06-26

    Oil pollution to aquatic devices, especially to those oil-cleaning devices and equipment-repairing robots during oil spill accidents, has drawn great attention and remains an urgent problem to be resolved. Developing devices that can move freely in an oil/water system without contamination from oil has both scientific and practical importance. In nature, the insect water strider can float on water by utilizing the superhydrophobic supporting force received by its legs. Inspired by this unique floating phenomenon, in this article, we designed a model device named "oil strider" that could float stably at the oil/water interface without contamination by oil. The floating capability of the oil strider originated from the huge underwater superoleophobic supporting force its "legs" received. We prepared the micro/nanohierarchical structured copper-oxide-coated copper wires, acting as the artificial legs of oil strider, by a simple base-corrosion process. The surface structures and hydrophilic chemical components of the coatings on copper wires induced the huge superoleophobic force at the oil/water interface, to support the oil strider from sinking into the oil. Experimental results and theoretical analysis demonstrate that this supporting force is mainly composed of three parts: the buoyancy force, the curvature force, and the deformation force. We anticipate that this artificial oil strider will provide a guide for the design of smart aquatic devices that can move freely in an oil/water system with excellent oil repellent capability, and be helpful in practical situations such as oil handling and oil spill cleanup.

  14. Open Search Environments: The Free Alternative to Commercial Search Services

    Directory of Open Access Journals (Sweden)

    Adrian O'Riordan

    2014-06-01

    Full Text Available Open search systems present a free and less restricted alternative to commercial search services. This paper explores the space of open search technology looking in particular at the issue of interoperability. A description of current protocols and formats for engineering open search applications is presented. The suitability of these technologies and issues around their adoption and operation are discussed. This open search approach is especially proving a fitting choice in applications involving the harvesting of resources and information integration. Principal among the technological solutions are OpenSearch and SRU. OpenSearch and SRU implement a federated model to enable existing and new search engines and search clients communicate. Applications and instances where Opensearch and SRU can be combined are presented. Other relevant technologies such as OpenURL, Apache Solr, and OAI-PMH are also discussed. The deployment of these freely licensed open standards in digital library applications is now a genuine alternative to commercial or proprietary systems.

  15. Internet Search Engines

    OpenAIRE

    Fatmaa El Zahraa Mohamed Abdou

    2004-01-01

    A general study about the internet search engines, the study deals main 7 points; the differance between search engines and search directories, components of search engines, the percentage of sites covered by search engines, cataloging of sites, the needed time for sites appearance in search engines, search capabilities, and types of search engines.

  16. Internet Search Engines

    Directory of Open Access Journals (Sweden)

    Fatmaa El Zahraa Mohamed Abdou

    2004-09-01

    Full Text Available A general study about the internet search engines, the study deals main 7 points; the differance between search engines and search directories, components of search engines, the percentage of sites covered by search engines, cataloging of sites, the needed time for sites appearance in search engines, search capabilities, and types of search engines.

  17. The platelet-to-lymphocyte ratio predicts poor survival in patients with huge hepatocellular carcinoma that received transarterial chemoembolization.

    Science.gov (United States)

    Xue, Tong-Chun; Jia, Qing-An; Ge, Ning-Ling; Zhang, Bo-Heng; Wang, Yan-Hong; Ren, Zheng-Gang; Ye, Sheng-Long

    2015-08-01

    Inflammation is particularly strong in huge hepatocellular carcinoma (HCC). However, it is unclear whether the platelet-to-lymphocyte ratio (PLR), as an inflammatory-related marker, can predict survival of patients with huge HCC. In this study, we enrolled 291 patients with huge HCC (diameter over 10 cm) who were undergoing repeated transarterial chemoembolization (TACE) at our institute. The baseline PLR was calculated from complete serum blood counts before the first chemoembolization. We found that a baseline PLR cutoff value over 150 best predicted huge HCC survival. The 12, 24, and 36 months survival rates in the high PLR group (22.6, 8.1, and 4.1 %, respectively) were significantly lower than in the low PLR group (35.6, 22.4, and 14 %, respectively). Thus, a significant difference was found in overall survival (log-rank test, p huge HCC, a high baseline PLR is a useful predictor of poor survival in patients undergoing chemoembolization. Additional anti-inflammatory or anti-platelet treatments, in combination with TACE, may improve survival in HCC patients with high PLR.

  18. The value of a formula including haematocrit, blood urea and gender (HUGE) as a screening test for chronic renal insufficiency.

    Science.gov (United States)

    Alvarez-Gregori, J A; Robles, N R; Mena, C; Ardanuy, R; Jauregui, R; Macas-Nu Nunez, J F

    2011-06-01

    Despite increasing use in clinical practice, an estimated glomerular filtration rate value (eGFR) of HUGE formula. A formula including haematocrit , blood urea, and gender (HUGE), diagnoses CRI regardless of the variables of age, blood creatinine, creatinine clearance, or other eGFR. The HUGE formula is: L = 2.505458 - (0.264418 x Hematocrit) + (0.118100 x Urea) [+ 1.383960 if male]. If L is a negative number the individual does not have CRI; if L is a positive number, CRI is present. Our data demonstrate that the HUGE formula is more reliable than MDRD and CKD-EPI, particularly in persons aged over 70. Our HUGE screening formula offers a straightforward, easily available and inexpensive method for differentiating between CRI and eGFR < 60 ml/min/1.73 m2 that will prevent a considerable number of aged healthy persons, as much as 1.700.000 in Spain and 2.600.000 in U.K., to be excluded from clinical assays or treatments contraindicated in CRI.

  19. [COMBINED POSTERIOR AND ANTERIOR APPROACHES FOR RESECTION OF THORACOLUMBAR SPINAL HUGE DUMBBELL-SHAPED TUMOR].

    Science.gov (United States)

    Shi, Jiandang; Zhao, Chen; Ding, Huiqiang; Fu, Bin; Niu, Ningkui; Yue, Xuefeng; Yang, Zongqiang; He, Yin

    2016-02-01

    To investigate the surgical outcome of combined posterior and anterior approaches for the resection of thoracolumbar spinal canal huge dumbbell-shaped tumor. Between January 2009 and March 2015, 12 patients with thoracolumbar spinal canal huge dumbbell-shaped tumor were treated by posterior approach and anterolateral approach through diaphragmatic crura and thoracoabdominal incision for complete resection. There were 9 males and 3 females, with an average age of 45 years (range, 30-65 years). The disease duration was 8-64 weeks (mean, 12.7 weeks). The tumor was located at T(12), L1 in 6 cases, at L(1,2) in 5 cases, and at L(2,3) in 1 case. The tumor size ranged from 4.3 cm x 4.0 cm x 3.5 cm to 7.5 cm x 6.3 cm x 6.0 cm. According to tumor outside the spinal involvement scope and site and based on the typing of Eden, 5 cases were rated as type b, 2 cases as type d, 4 cases as type e, and 1 case as type f in the transverse direction; two segments were involved in 8 cases, and more than two segments in 4 cases. The degree of tumor excision, tumor recurrence, and the spine stability were observed during follow-up. The verbal rating scale (VRS) was used to evaluate pain improvement. The average surgical time was 170 minutes (range, 150-230 minutes); the average intraoperative blood loss was 350 mL (range, 270-600 mL). All incisions healed by first intention, and no thoracic cavity infection and other operation related complication occurred. Of 12 cases, 10 were histologically confirmed as schwannoma, and 2 as neurofibroma. The patients were followed up 6 months to 6 years (mean, 31 months). Neurological symptoms were significantly improved in all patients, without lower back soreness. The thoracolumbar X-ray film and MRI showed no tumor residue. No tumor recurrence, internal fixator loosening, scoliosis, and other complications were observed during follow-up. VRS at last follow-up was significantly improved to grade 0 (10 cases) or grade 1 (2 cases) from preoperative

  20. Partial reactivation of a huge deep-seated ancient rock slide: recognition, formation mechanism, and stability

    Science.gov (United States)

    Tang, Minggao; Xu, Qiang; Li, Yusheng; Huang, Runqiu; Rengers, Niek; Zhu, Xing

    2016-08-01

    About 18 years ago, a large-scale discontinuous layer in properties and colour was found in the new Fengjie town at the shore of the Three Gorges Reservoir area in China. There are many resettled residents and buildings on the sloping area, the safety of which is potentially affected by this layer, so it has become the focus of attention. Before this study started there were two viewpoints regarding the origin of this layer. One was that is was from a huge ancient slide and the other was that is was from a fault graben. In order to find out how it was formed and to be able to carry out a stability analysis of the slope the authors have carried out a research program, including geological field investigations and mapping, a deep drilling hole, a geotechnical centrifuge model test, and a simulation analysis. The results of the research led to the conclusion that the layer is the sliding plane of a huge deep-seated ancient rock slide, which we called the Sanmashan landslide. An important argument for the conclusion is the recognition of a regional compressive tectonic stress field in this area, which cannot lead to the formation of a fault graben because it needs a tensional tectonic stress field. Moreover, numerous unique geological features, sliding marks, and other relics of the ancient slide have been discovered in the field. The formation process of the ancient slide could be repeated in a large geotechnical centrifuge model test. The test shows that a deformation and failure process of "creep-crack-cut" has occurred. The type of the ancient slide can be classified as a "successive rotational rock slide". Finally, the role of seepage in the stability of the Sanmashan landslide has been analysed. Our final conclusions are that, during rainfall and filling-drawdown cycles in the Three Gorges Reservoir, the Sanmashan landslide as a whole is dormant and stable and the secondary landslides in the toe area of the slope are presently stable but can be reactivated. This

  1. Search for $\

    OpenAIRE

    Astier, P.; Autiero, D.; Baldisseri, A.; Baldo-Ceolin, M.; Banner, M.; Bassompierre, G.; Benslama, K.; Besson, N.; Bird, I.; Blumenfeld, B.; Bobisut, F.; J. Bouchez; Boyd, S.; A. Bueno; Bunyatov, S.

    2003-01-01

    Neutrinos; We present the results of a search for nu_mu → nu_e oscillations in the NOMAD experiment at Cern. The experiment looked for the appearance of nu_e in a predominantly nu_mu wide-band neutrino beam at the CERN SPS. No evidence for oscillations was found. The 90% confidence limits obtained are Delta m^2 ~ 10 eV^2.

  2. Search for $\

    CERN Document Server

    Astier, Pierre; Baldisseri, Alberto; Baldo-Ceolin, Massimilla; Banner, M; Bassompierre, Gabriel; Benslama, K; Besson, N; Bird, I; Blumenfeld, B; Bobisut, F; Bouchez, J; Boyd, S; Bueno, A G; Bunyatov, S A; Camilleri, L L; Cardini, A; Cattaneo, Paolo Walter; Cavasinni, V; Cervera-Villanueva, A; Challis, R C; Chukanov, A; Collazuol, G; Conforto, G; Conta, C; Contalbrigo, M; Cousins, R D; Daniels, D; De Santo, A; Degaudenzi, H M; Del Prete, T; Di Lella, L; Dignan, T; Dumarchez, J; Feldman, G J; Ferrari, A; Ferrari, R; Ferrère, D; Flaminio, Vincenzo; Fraternali, M; Gaillard, J M; Gangler, E; Geiser, A; Geppert, D; Gibin, D; Gninenko, S N; Godley, A; Gosset, J; Gouanère, M; Grant, A; Graziani, G; Guglielmi, A M; Gómez-Cadenas, J J; Gössling, C; Hagner, C; Hernando, J; Hong, T M; Hubbard, D B; Hurst, P; Hyett, N; Iacopini, E; Joseph, C L; Juget, F R; Kent, N; Kirsanov, M M; Klimov, O; Kokkonen, J; Kovzelev, A; Krasnoperov, A V; Kustov, D; La Rotonda, L; Lacaprara, S; Lachaud, C; Lakic, B; Lanza, A; Laveder, M; Letessier-Selvon, A A; Linssen, Lucie; Ljubicic, A; Long, J; Lupi, A; Lévy, J M; Marchionni, A; Martelli, F; Mendiburu, J P; Meyer, J P; Mezzetto, Mauro; Mishra, S R; Moorhead, G F; Méchain, X; Naumov, D V; Nefedov, Yu A; Nguyen-Mau, C; Nédélec, P; Orestano, D; Pastore, F; Peak, L S; Pennacchio, E; Pessard, H; Petti, R; Placci, A; Polesello, G; Pollmann, D; Polyarush, A Yu; Popov, B; Poulsen, C; Rebuffi, L; Renò, R; Rico, J; Riemann, P; Roda, C; Rubbia, André; Salvatore, F; Schahmaneche, K; Schmidt, B; Schmidt, T; Sconza, A; Sevior, M E; Shih, D; Sillou, D; Soler, F J P; Sozzi, G; Steele, D; Stiegler, U; Stipcevic, M; Stolarczyk, T; Tareb-Reyes, M; Taylor, G N; Tereshchenko, V V; Toropin, A N; Touchard, A M; Tovey, Stuart N; Tran, M T; Tsesmelis, E; Ulrichs, J; Vacavant, L; Valdata-Nappi, M; Valuev, V Yu; Vannucci, François; Varvell, K E; Veltri, M; Vercesi, V; Vidal-Sitjes, G; Vieira, J M; Vinogradova, T G; Weber, F V; Weisse, T; Wilson, F F; Winton, L J; Yabsley, B D; Zaccone, Henri; Zuber, K; Zuccon, P; do Couto e Silva, E

    2003-01-01

    We present the results of a search for nu_mu → nu_e oscillations in the NOMAD experiment at Cern. The experiment looked for the appearance of nu_e in a predominantly nu_mu wide-band neutrino beam at the CERN SPS. No evidence for oscillations was found. The 90% confidence limits obtained are Delta m^2 ~ 10 eV^2.

  3. Search for $\

    CERN Document Server

    Astier, Pierre; Baldisseri, Alberto; Baldo-Ceolin, Massimilla; Banner, M; Bassompierre, Gabriel; Benslama, K; Besson, N; Bird, I; Blumenfeld, B; Bobisut, F; Bouchez, J; Boyd, S; Bueno, A G; Bunyatov, S; Camilleri, L L; Cardini, A; Cattaneo, Paolo Walter; Cavasinni, V; Cervera-Villanueva, A; Challis, R C; Chukanov, A; Collazuol, G; Conforto, G; Conta, C; Contalbrigo, M; Cousins, R; Daniels, D; Degaudenzi, H M; Del Prete, T; De Santo, A; Dignan, T; Di Lella, L; do Couto e Silva, E; Dumarchez, J; Ellis, M; Feldman, G J; Ferrari, R; Ferrère, D; Flaminio, Vincenzo; Fraternali, M; Gaillard, J M; Gangler, E; Geiser, A; Geppert, D; Gibin, D; Gninenko, S N; Godley, A; Gómez-Cadenas, J J; Gosset, J; Gössling, C; Gouanère, M; Grant, A; Graziani, G; Guglielmi, A M; Hagner, C; Hernando, J A; Hubbard, D B; Hurst, P; Hyett, N; Iacopini, E; Joseph, C L; Juget, F R; Kent, N; Kirsanov, M M; Klimov, O; Kokkonen, J; Kovzelev, A; Krasnoperov, A V; Kustov, D; Lacaprara, S; Lachaud, C; Lakic, B; Lanza, A; La Rotonda, L; Laveder, M; Letessier-Selvon, A A; Lévy, J M; Linssen, Lucie; Ljubicic, A; Long, J; Lupi, A; Marchionni, A; Martelli, F; Méchain, X; Mendiburu, J P; Meyer, J P; Mezzetto, Mauro; Mishra, S R; Moorhead, G F; Naumov, D V; Nédélec, P; Nefedov, Yu A; Nguyen-Mau, C; Orestano, D; Pastore, F; Peak, L S; Pennacchio, E; Pessard, H; Petti, R; Placci, A; Polesello, G; Pollmann, D; Polyarush, A Yu; Popov, B; Poulsen, C; Rebuffi, L; Renò, R; Rico, J; Riemann, P; Roda, C; Rubbia, André; Salvatore, F; Schahmaneche, K; Schmidt, B; Schmidt, T; Sconza, A; Sevior, M E; Sillou, D; Soler, F J P; Sozzi, G; Steele, D; Stiegler, U; Stipcevic, M; Stolarczyk, T; Tareb-Reyes, M; Taylor, G; Tereshchenko, V V; Toropin, A N; Touchard, A M; Tovey, Stuart N; Tran, M T; Tsesmelis, E; Ulrichs, J; Vacavant, L; Valdata-Nappi, M; Valuev, V Y; Vannucci, François; Varvell, K E; Veltri, M; Vercesi, V; Vidal-Sitjes, G; Vieira, J M; Vinogradova, T G; Weber, F V; Weisse, T; Wilson, F F; Winton, L J; Yabsley, B D; Zaccone, Henri; Zuber, K; Zuccon, P

    2001-01-01

    We present the results of a search for nu(mu)-->nu(e) oscillations in the NOMAD experiment at CERN. The experiment looked for the appearance of nu(e) in a predominantly nu(mu) wide-band neutrino beam at the CERN SPS. No evidence for oscillations was found. The 90% confidence limits obtained are delta m^2 10 eV^2.

  4. Improved Degree Search Algorithms in Unstructured P2P Networks

    Directory of Open Access Journals (Sweden)

    Guole Liu

    2012-01-01

    Full Text Available Searching and retrieving the demanded correct information is one important problem in networks; especially, designing an efficient search algorithm is a key challenge in unstructured peer-to-peer (P2P networks. Breadth-first search (BFS and depth-first search (DFS are the current two typical search methods. BFS-based algorithms show the perfect performance in the aspect of search success rate of network resources, while bringing the huge search messages. On the contrary, DFS-based algorithms reduce the search message quantity and also cause the dropping of search success ratio. To address the problem that only one of performances is excellent, we propose two memory function degree search algorithms: memory function maximum degree algorithm (MD and memory function preference degree algorithm (PD. We study their performance including the search success rate and the search message quantity in different networks, which are scale-free networks, random graph networks, and small-world networks. Simulations show that the two performances are both excellent at the same time, and the performances are improved at least 10 times.

  5. Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma.

    Science.gov (United States)

    Nomiya, Takuma; Akamatsu, Hiroko; Harada, Mayumi; Ota, Ibuki; Hagiwara, Yasuhito; Ichikawa, Mayumi; Miwa, Misako; Kawashiro, Shouhei; Hagiwara, Motohisa; Chin, Masahiro; Hashizume, Eiji; Nemoto, Kenji

    2014-12-28

    A clinical trial of radiotherapy with modified simultaneous integrated boost (SIB) technique against huge tumors was conducted. A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this trial. The total dose of 77 Gy (equivalent dose in 2 Gy/fraction) and 64.5 Gy was delivered to the center of the tumor and the surrounding area respectively, and approximately 20% dose escalation was achieved with the modified SIB technique. The tumor with an initial maximum size of 15 cm disappeared 120 d after the start of the radiotherapy. Performance status of the patient improved from 4 to 0. Radiotherapy with modified SIB may be effective for patients with a huge tumor in terms of tumor shrinkage/disappearance, improvement of QOL, and prolongation of survival.

  6. MR-based truncation and attenuation correction in integrated PET/MR hybrid imaging using HUGE with continuous table motion.

    Science.gov (United States)

    Lindemann, Maike E; Oehmigen, Mark; Blumhagen, Jan O; Gratz, Marcel; Quick, Harald H

    2017-09-01

    The objective of this study was to introduce and evaluate a method for MR-based attenuation and truncation correction in phantom and patient measurements to improve PET quantification in PET/MR hybrid imaging. The fully MR-based method HUGE (B0 Homogenization using gradient enhancement) provides field-of-view extension in MR imaging, which can be used for truncation correction and improved PET quantification in PET/MR hybrid imaging. The HUGE method in this recent implementation is combined with continuously moving table data acquisition to provide a seamless nontruncated whole-body data set of the outer patient contours to complete the established standard MR-based Dixon-VIBE data for attenuation correction. The method was systematically evaluated in NEMA standard phantom experiments to investigate the impact of HUGE truncation correction on PET quantification. The method was then applied to 24 oncologic patients in whole-body PET/MR hybrid imaging. The impact of MR-based truncation correction with HUGE on PET data was compared to the impact of the established PET-based MLAA algorithm for contour detection. In phantom and in all patient measurements, the standard Dixon-VIBE attenuation correction data show geometric distortions and signal truncations at the edges of the MR imaging field-of-view. In contrast, the Dixon-VIBE-based attenuation correction data additionally extended by applying HUGE shows significantly less distortion and truncations and due to the continuously moving table acquisition robustly provides smooth outer contours of the patient arms. In the investigated patient cases, MLAA frequently showed an overestimation of arm volume and associated artifacts limiting contour detection. When applying HUGE, an average relative increase in SUVmean in patients' lesion of 4.2% and for MLAA of 4.6% were measured, when compared to standard Dixon-VIBE only. In specific lesions maximal differences in SUVmean up to 13% for HUGE and 14% for MLAA were measured

  7. Youth, Myspace, and the Interstitial Spaces of Becoming and Belonging

    Science.gov (United States)

    Macintosh, Lori; Bryson, Mary

    2008-01-01

    This essay provides a queer reading of MySpace (http://www.MySpace.com). The analysis engages how this hugely popular youth site, as exemplar of online peer-to-peer networking, might provide educators and researchers with an ideal location for asking good questions about queer relationalities within hyper-mediated spaces. Social networking sites…

  8. Understanding and classifying metabolite space and Metabolite-Likeness

    NARCIS (Netherlands)

    Peironcely, J.E.; Reijmers, T.; Coulier, L.; Bender, A.; Hankemeier, T.

    2011-01-01

    While the entirety of 'Chemical Space' is huge (and assumed to contain between 1063 and 10200 'small molecules'), distinct subsets of this space can nonetheless be defined according to certain structural parameters. An example of such a subspace is the chemical space spanned by endogenous metabolite

  9. The Asean Space Organization : legal aspects and feasibility

    NARCIS (Netherlands)

    Noichim, Chukeat

    2008-01-01

    In the 21st century, space activities increasingly affect global society, economy, technology, culture, and the environment. Many countries wish to develop space activities in order to obtain space benefits. However, a lot of them, especially developing countries, face huge obstacles such as lack of

  10. The Asean Space Organization : legal aspects and feasibility

    NARCIS (Netherlands)

    Noichim, Chukeat

    2008-01-01

    In the 21st century, space activities increasingly affect global society, economy, technology, culture, and the environment. Many countries wish to develop space activities in order to obtain space benefits. However, a lot of them, especially developing countries, face huge obstacles such as lack of

  11. Huge nanodielectric effects in polyimide/boron nitride nanocomposites revealed by the nanofiller size

    Science.gov (United States)

    Diaham, S.; Saysouk, F.; Locatelli, M.-L.; Lebey, T.

    2015-09-01

    The dielectric properties of polyimide/boron nitride (PI/BN) nanocomposite films are investigated as a function of the BN nanofiller size from 20 to 350 °C and at low filler content (1-2 vol.%). The role of the BN nanofiller size on the large reduction of the electrode polarization relaxation phenomenon due to ionic movements is reported. For the two smallest BN nanoparticles (95 nm and 35 nm), the permittivity, dielectric losses and dc conductivity are strongly attenuated above 200 °C by a factor of 10 to 1000 compared to neat PI. Thus, the dc conductivity at 350 °C is reduced from 4   ×   10-8 Ω-1 cm-1 for neat PI to 3   ×   10-11 Ω-1 cm-1 for PI/BN (35 nm). Moreover, a further decrease is obtained by functionalizing the nanofiller surface with a silane coupling agent which improves the grafting of PI chains on those latter nanoparticles. These results highlight the trapping efficiency in the interphase region introduced by the small BN nanofillers (<100 nm) and provides evidence as to the huge nanodielectric effects on the charge carrier transport controlled by the nanoparticle diameter. This finding should be of great importance for advanced high temperature electrical insulation in the future.

  12. Huge thermal conductivity enhancement in boron nitride – ethylene glycol nanofluids

    Energy Technology Data Exchange (ETDEWEB)

    Żyła, Gaweł, E-mail: gzyla@prz.edu.pl [Department of Physics and Medical Engineering, Rzeszow University of Technology, Rzeszow, 35-905 (Poland); Fal, Jacek; Traciak, Julian [Department of Physics and Medical Engineering, Rzeszow University of Technology, Rzeszow, 35-905 (Poland); Gizowska, Magdalena; Perkowski, Krzysztof [Department of Nanotechnology, Institute of Ceramics and Building Materials, Warsaw, 02-676 (Poland)

    2016-09-01

    Paper presents the results of experimental studies on thermophysical properties of boron nitride (BN) plate-like shaped particles in ethylene glycol (EG). Essentially, the studies were focused on the thermal conductivity of suspensions of these particles. Nanofluids were obtained with two-step method (by dispersing BN particles in ethylene glycol) and its’ thermal conductivity was analyzed at various mass concentrations, up to 20 wt. %. Thermal conductivity was measured in temperature range from 293.15 K to 338.15 K with 15 K step. The measurements of thermal conductivity of nanofluids were performed in the system based on a device using the transient line heat source method. Studies have shown that nanofluids’ thermal conductivity increases with increasing fraction of nanoparticles. The results of studies also presented that the thermal conductivity of nanofluids changes very slightly with the increase of temperature. - Highlights: • Huge thermal conductivity enhancement in BN-EG nanofluid was reported. • Thermal conductivity increase very slightly with increasing of the temperature. • Thermal conductivity increase linearly with volume concentration of particles.

  13. Synovial sarcoma presenting with huge mediastinal mass: a case report and review of literature

    Science.gov (United States)

    2013-01-01

    Background Synovial sarcoma presenting in the mediastinum is exceedingly rare. Furthermore, data addressing optimal therapy is limited. Herein we present a case where an attempt to downsize the tumor to a resectable state with chemotherapy was employed. Case presentation A 32 year female presented with massive pericardial effusion and unresectable huge mediastinal mass. Computed axial tomography scan - guided biopsy with adjunctive immunostains and molecular studies confirmed a diagnosis of synovial sarcoma. Following three cycles of combination Ifosfamide and doxorubicin chemotherapy, no response was demonstrated. The patient refused further therapy and had progression of her disease 4 months following the last cycle. Conclusion Synovial sarcoma presenting with unresectable mediastinal mass carry a poor prognosis. Up to the best of our knowledge there are only four previous reports where primary chemotherapy was employed, unfortunately; none of these cases had subsequent complete surgical resection. Identification of the best treatment strategy for patients with unresectable disease is warranted. Our case can be of benefit to medical oncologists and thoracic surgeons who might be faced with this unique and exceedingly rare clinical scenario. PMID:23800262

  14. Unexpected Huge Dimerization Ratio in One-Dimensional Carbon Atomic Chains.

    Science.gov (United States)

    Lin, Yung-Chang; Morishita, Shigeyuki; Koshino, Masanori; Yeh, Chao-Hui; Teng, Po-Yuan; Chiu, Po-Wen; Sawada, Hidetaka; Suenaga, Kazutomo

    2017-01-11

    Peierls theory predicted atomic distortion in one-dimensional (1D) crystal due to its intrinsic instability in 1930. Free-standing carbon atomic chains created in situ in transmission electron microscope (TEM)1-3 are an ideal example to experimentally observe the dimerization behavior of carbon atomic chain within a finite length. We report here a surprisingly huge distortion found in the free-standing carbon atomic chains at 773 K, which is 10 times larger than the value expected in the system. Such an abnormally distorted phase only dominates at the elevated temperatures, while two distinct phases, distorted and undistorted, coexist at lower or ambient temperatures. Atom-by-atom spectroscopy indeed shows considerable variations in the carbon 1s spectra at each atomic site but commonly observes a slightly downshifted π* peak, which proves its sp(1) bonding feature. These results suggest that the simple model, relaxed and straight, is not fully adequate to describe the realistic 1D structure, which is extremely sensitive to perturbations such as external force or boundary conditions.

  15. A Huge Capital Drop with Compression of Femoral Vessels Associated with Hip Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Tomoya Takasago

    2015-01-01

    Full Text Available A capital drop is a type of osteophyte at the inferomedial portion of the femoral head commonly observed in hip osteoarthritis (OA, secondary to developmental dysplasia. Capital drop itself is typically asymptomatic; however, symptoms can appear secondary to impinge against the acetabulum or to irritation of the surrounding tissues, such as nerves, vessels, and tendons. We present here a case of unilateral leg edema in a patient with hip OA, caused by a huge bone mass occurring at the inferomedial portion of the femoral head that compressed the femoral vessels. We diagnosed this bone mass as a capital drop secondary to hip OA after confirming that the mass occurred at least after the age of 63 years based on a previous X-ray. We performed early resection and total hip arthroplasty since the patient’s hip pain was due to both advanced hip OA and compression of the femoral vessels; moreover, we aimed to prevent venous thrombosis secondary to vascular compression considering the advanced age and the potent risk of thrombosis in the patient. A large capital drop should be considered as a cause of vascular compression in cases of unilateral leg edema in OA patients.

  16. Acute abdomen in early pregnancy caused by torsion of bilateral huge multiloculated ovarian cysts

    Directory of Open Access Journals (Sweden)

    Sathiyakala Rajendran

    2015-10-01

    Full Text Available The association of pregnancy and torsion of bilateral huge benign ovarian cyst is rare. We report a case of multigravida at 13 weeks of pregnancy presenting with acute onset of lower abdominal pain. Ultrasound revealed bilateral multiloculated ovarian cysts of size 10x10 cm on right side and 15x10cm on left side with evidence of torsion and a single live intrauterine fetus of gestational age 13 weeks 4 days. Emergency laparotomy was done with vaginal susten 200 mg as perioperative tocolysis. Intra operatively, uterus was enlarged to 14 weeks size. Both ovaries were replaced with multiloculated cysts of size 15x10 cm on left side and 10x10 cm on right side. Ovarian pedicle was found to be twisted once on right side and twice on left side. On right side, untwisting of pedicle was done and the ovarian cyst was punctured at multiple sites to drain the clear fluid. Biopsy was taken from the right ovarian cyst wall. On left side, ovariotomy was done. Histopathology revealed mucinous cyst adenoma of left ovary and multiple corpus luteum in right ovarian biopsy specimen. The patient was followed up with regular antenatal check-ups and ultrasound to rule out the recurrence of ovarian cyst on right side. The patient successfully delivered a term male baby at 39 weeks. [Int J Reprod Contracept Obstet Gynecol 2015; 4(5.000: 1598-1601

  17. Propranolol in Treatment of Huge and Complicated Infantile Hemangiomas in Egyptian Children

    Directory of Open Access Journals (Sweden)

    Basheir A. Hassan

    2014-01-01

    Full Text Available Background. Infantile hemangiomas (IHs are the most common benign tumours of infancy. Propranolol has recently been reported to be a highly effective treatment for IHs. This study aimed to evaluate the efficacy and side effects of propranolol for treatment of complicated cases of IHs. Patients and Methods. This prospective clinical study included 30 children with huge or complicated IHs; their ages ranged from 2 months to 1 year. They were treated by oral propranolol. Treatment outcomes were clinically evaluated. Results. Superficial cutaneous hemangiomas began to respond to propranolol therapy within one to two weeks after the onset of treatment. The mean treatment period that was needed for the occurrence of complete resolution was 9.4 months. Treatment with propranolol was well tolerated and had few side effects. No rebound growth of the tumors was noted when propranolol dosing stopped except in one case. Conclusion. Propranolol is a promising treatment for IHs without obvious side effects. However, further studies with longer follow-up periods are needed.

  18. Computational AstroStatistics Fast and Efficient Tools for Analysing Huge Astronomical Data Sources

    CERN Document Server

    Nichol, R C; Connolly, A J; Davies, S; Genovese, C; Hopkins, A M; Miller, C J; Moore, A W; Pelleg, D; Richards, G T; Schneider, J; Szapudi, I; Wasserman, L H

    2001-01-01

    I present here a review of past and present multi-disciplinary research of the Pittsburgh Computational AstroStatistics (PiCA) group. This group is dedicated to developing fast and efficient statistical algorithms for analysing huge astronomical data sources. I begin with a short review of multi-resolutional kd-trees which are the building blocks for many of our algorithms. For example, quick range queries and fast n-point correlation functions. I will present new results from the use of Mixture Models (Connolly et al. 2000) in density estimation of multi-color data from the Sloan Digital Sky Survey (SDSS). Specifically, the selection of quasars and the automated identification of X-ray sources. I will also present a brief overview of the False Discovery Rate (FDR) procedure (Miller et al. 2001a) and show how it has been used in the detection of ``Baryon Wiggles'' in the local galaxy power spectrum and source identification in radio data. Finally, I will look forward to new research on an automated Bayes Netw...

  19. Distributed data organization and parallel data retrieval methods for huge laser scanner point clouds

    Science.gov (United States)

    Hongchao, Ma; Wang, Zongyue

    2011-02-01

    This paper proposes a novel method for distributed data organization and parallel data retrieval from huge volume point clouds generated by airborne Light Detection and Ranging (LiDAR) technology under a cluster computing environment, in order to allow fast analysis, processing, and visualization of the point clouds within a given area. The proposed method is suitable for both grid and quadtree data structures. As for distribution strategy, cross distribution of the dataset would be more efficient than serial distribution in terms of non-redundant datasets, since a dataset is more uniformly distributed in the former arrangement. However, redundant datasets are necessary in order to meet the frequent need of input and output operations in multi-client scenarios: the first copy would be distributed by a cross distribution strategy while the second (and later) would be distributed by an iterated exchanging distribution strategy. Such a distribution strategy would distribute datasets more uniformly to each data server. In data retrieval, a greedy algorithm is used to allocate the query task to a data server, where the computing load is lightest if the data block needing to be retrieved is stored among multiple data servers. Experiments show that the method proposed in this paper can satisfy the demands of frequent and fast data query.

  20. New algorithms for radio pulsar search

    CERN Document Server

    Smith, Kendrick M

    2016-01-01

    The computational cost of searching for new pulsars is a limiting factor for upcoming radio telescopes such as SKA. We introduce four new algorithms: an optimal constant-period search, a coherent tree search which permits optimal searching with O(1) cost per model, a semicoherent search which combines information from coherent subsearches while preserving as much phase information as possible, and a hierarchical search which interpolates between the coherent and semicoherent limits. Taken together, these algorithms improve the computational cost of pulsar search by several orders of magnitude. In this paper, we consider the simple case of a constant-acceleration phase model, but our methods should generalize to more complex search spaces.

  1. Angiomyolipoma of the perinephric space: case report

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Ho Seob; Yoon, Seong Kuk; Lee, Jin Hwa; Kim, Chan sung; Oh, Jong Young; Shin, Tae Beom; Lee, Ki Nam; Nam, Kyung Jin; Kim, Dae Cheol [Dong a University College of Medicine, Busan (Korea, Republic of)

    2002-12-01

    Angiomyolipomas commonly originate from neral parenchyma but extremely rarely from perinephric space. We report a case of angiomyolipoma of the perinephric space confirmed by radical nephrectomy. A 13-year-old boy resented with left flank pain and abdominal distension, first experienced five months earlier. Ultrasonography and CT indicated that in the space surrounding the left kidney, a huge fat-containing mass with linear strands was present.

  2. A Survey on Web Search Results Personalization

    Directory of Open Access Journals (Sweden)

    Blessy Thomas

    2015-10-01

    Full Text Available  Web is a huge information repository covering almost every topic, in which a human user could be interested. As the size and richness of information on the web increases, diversity and complexity of the tasks users tries to perform also increases. With the overwhelming volume of information on the web, the task of finding relevant information related to a specific query or topic is becoming increasingly difficult. Now a day’s commonly used task on internet is web search. User gets variety of related information for their queries. To provide more relevant and effective results to user, Personalization technique is used. Personalized web search refer to search information that is tailored specifically to a person’s interests by incorporating information about query provided. Two general types of approaches to personalizing search results are modifying user’s query and re-ranking search results. Several personalized web search techniques based on web contents, web link structure, browsing history, user profiles and user queries. This paper is to represent survey on various techniques of personalization

  3. Autonomous Search

    CERN Document Server

    Hamadi, Youssef; Saubion, Frédéric

    2012-01-01

    Decades of innovations in combinatorial problem solving have produced better and more complex algorithms. These new methods are better since they can solve larger problems and address new application domains. They are also more complex which means that they are hard to reproduce and often harder to fine-tune to the peculiarities of a given problem. This last point has created a paradox where efficient tools are out of reach of practitioners. Autonomous search (AS) represents a new research field defined to precisely address the above challenge. Its major strength and originality consist in the

  4. Search in

    OpenAIRE

    Gaona Román, Alejandro

    2015-01-01

    "Search in" consiste en una instalación artística compuesta por escultura y video con un trasfondo conceptual sobre la identidad. Es una obra que invita al espectador a rodearla e introducirse en ella viéndose así como parte de la obra, al igual que el concepto de identidad puede vivirse desde la sensación del “yo” separado del mundo y a su vez desde el “yo” como parte de la sociedad. Nos hace viajar desde nuestros inicios como sociedad y seres conscientes hasta la actualidad, la era de las c...

  5. Beyond Spaces of Counselling

    DEFF Research Database (Denmark)

    Bank, Mads; Nissen, Morten

    2015-01-01

    The article articulates experiments with spatial constructions in two Danish social work agencies, basing on a) a sketchy genealogical reconstruction of conceptualisations and uses of space in social work and counselling; b) a search for theoretical resources to articulate new spaces, and c) data...... from a long-standing collaboration with the social workers. Beside the classical disciplinary and pastoral spaces, we find spaces of attunement, spaces of production, and public spaces as forms of spatialisations which might be taken as prototypical in attempts to develop social work and counselling....

  6. Comparing NEO Search Telescopes

    CERN Document Server

    Myhrvold, Nathan

    2015-01-01

    Multiple terrestrial and space-based telescopes have been proposed for detecting and tracking near-Earth objects (NEOs). Detailed simulations of the search performance of these systems have used complex computer codes that are not widely available, which hinders accurate cross- comparison of the proposals and obscures whether they have consistent assumptions. Moreover, some proposed instruments would survey infrared (IR) bands, whereas others would operate in the visible band, and differences among asteroid thermal and visible light models used in the simulations further complicate like-to-like comparisons. I use simple physical principles to estimate basic performance metrics for the ground-based Large Synoptic Survey Telescope and three space-based instruments - Sentinel, NEOCam, and a Cubesat constellation. The performance is measured against two different NEO distributions, the Bottke et al. distribution of general NEOs, and the Veres et al. distribution of earth impacting NEO. The results of the comparis...

  7. Endovascular Treatment of the Huge Dissecting Aneurysms Involving the Basilar Artery by the Internal Trapping Technique: Technical Note

    Directory of Open Access Journals (Sweden)

    Shi-Qing Mu

    2015-01-01

    Full Text Available Background: The endovascular strategy of the huge dissecting aneurysms involving the basilar artery (BA is controversial and challenging. This study was to investigate the clinical and angiographic outcomes of the treatment of the huge dissecting aneurysms involving the BA by the internal trapping (IT technique. Methods: We retrospectively studied 15 patients with the huge dissecting aneurysms involving the BA treated by the IT technique between September 2005 and September 2014 in Department of Interventional Neuroradiology of Beijing Tiantan Hospital. Clinical and angiographic data were reviewed and evaluated. Results: All patients were treated by the IT technique. That meant the dissecting artery and aneurysm segments were completed occlusion. After the procedure, the angiography demonstrated that all the dissecting artery and aneurysm segments were completed occlusion. Follow-up angiography was performed at 3-6 months or 12-18 months after the endovascular treatment (median 8 months, 14 patients had a good recovery. Re-canalization occurred in one patient whose aneurysm involved in bilateral vertebral arteries and the two third of the middle-lower BA. After the second treatment, the patient died by the ventricular tachycardia. Conclusions: The IT technique is a technically feasible and safe alternative for the treatment of BA dissecting aneurysms, but it is not necessarily the safest or most definitive treatment modality. The ideal treatment of the huge dissecting aneurysms involving the BA remains debatable and must be investigated on a case-by-case basis.

  8. Endovascular Treatment of the Huge Dissecting Aneurysms Involving the Basilar Artery by the Internal Trapping Technique: Technical Note

    Institute of Scientific and Technical Information of China (English)

    Shi-Qing Mu; Xin-Jian Yang; You-Xiang Li; Chu-Han Jiang; Zhong-Xue Wu

    2015-01-01

    Background:The endovascular strategy of the huge dissecting aneurysms involving the basilar artery (BA) is controversial and challenging.This study was to investigate the clinical and angiographic outcomes of the treatment of the huge dissecting aneurysms involving the BA by the internal trapping (IT) technique.Methods:We retrospectively studied 15 patients with the huge dissecting aneurysms involving the BA treated by the IT technique between September 2005 and September 2014 in Department of lnterventional Neuroradiology of Beijing Tiantan Hospital.Clinical and angiographic data were reviewed and evaluated.Results:All patients were treated by the IT technique.That meant the dissecting artery and aneurysm segments were completed occlusion.After the procedure,the angiography demonstrated that all the dissecting artery and aneurysm segments were completed occlusion.Follow-up angiography was performed at 3-6 months or 12-18 months after the endovascular treatment (median 8 months),14 patients had a good recovery.Re-canalization occurred in one patient whose aneurysm involved in bilateral vertebral arteries and the two third of the middle-lower BA.After the second treatment,the patient died by the ventricular tachycardia.Conclusions:The IT technique is a technically feasible and safe alternative for the treatment of BA dissecting aneurysms,but it is not necessarily the safest or most definitive treatment modality.The ideal treatment of the huge dissecting aneurysms involving the BA remains debatable and must be investigated on a case-by-case basis.

  9. Treating Huge Tear-Drop Fracture of Axis With Trapezoidal Bone: A Case Report and Literature Review.

    Science.gov (United States)

    Yang, Xiaobin; Zheng, Bolong; Hao, Dingjun; Liu, Benyin; Yan, Liang; He, Baorong

    2015-11-01

    Case report and review of relevant literature. To discuss the surgical strategies and clinical outcome of managing huge tear drop fracture of axis. Teardrop fracture of axis is rarely seen, especially the huge type. The surgical technique is demanding because of the special anatomical structure and difficulty with bone grafting. Moreover, the surgical approach is controversial in the literature. A 51-year-old male patient suffered from neck pain after falling from the bicycle, neck movement was limited with no neurological compromise. X-ray suggested huge tear-drop fracture of anterior-inferior corner of axis, narrowing of C2/3 intervertebral disc. Fusion with self-designed tricortical trapezoidal iliac bone was performed. Treating huge teardrop fracture of axis by anterior bone grafting with self-designed tricortical trapezoidal iliac bone is effective and stable. A 3-month follow-up showed fusion was achieved, upper cervical curvature was restored, and neck pain disappeared. Self-designed tricortical trapezoidal iliac bone provided adequate fusion area of bone grafting, restoring the normal intervertebral height and cervical alignment, and the midterm outcome is satisfactory. 5.

  10. Huge pseudomyxoma peritonei: Surgical strategies and procedures to employ to optimize the rate of complete cytoreductive surgery.

    Science.gov (United States)

    Benhaim, L; Honoré, C; Goéré, D; Delhorme, J-B; Elias, D

    2016-04-01

    Complete cytoreductive surgery (CCRS) plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is the best-known treatment for pseudomyxoma peritonei (PMP). In 30% of the cases, PMP realize a widespread involvement of the peritoneal cavity. In these extreme situations, we developed, devoted strategies to optimize the feasibility and safety of CCRS. This study describes the surgical resections required for CCRS and the consequent approaches that we propose to achieve CCRS. We defined "huge PMP" by a peritoneal cancer index (PCI) ≥ 28. Surgical procedures of patients operated on between 1994 and 2014 were retrospectively reviewed from a prospective database in a single institution. During this period, 311 patients were operated on and 247 (79%) underwent CCRS + HIPEC. Among them, 100 patients presented "huge" PMP and 54 patients underwent CCRS + HIPEC. In patients with "huge" PMP, the rate of CCRS + HIPEC was 25% before 2002 and reached 71% between 2011 and 2014. We identified 3 conditions for CCRS 1) to guaranty a sufficient length of residual small bowel 2) to preserve the left gastric vessels in order to preserve the superior third of the stomach 3) to ensure that the hepatic pedicle can be entirely cleared from its tumor involvement. None of the other peritonectomy procedures were decisional for CCRS. Our learning curve improved the selection and completion rate of CCRS + HIPEC for "huge PMP". Some anatomical and physiological prerequisites guarantee the feasibility and safety of such extensive surgeries. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Endovascular Treatment of the Huge Dissecting Aneurysms Involving the Basilar Artery by the Internal Trapping Technique: Technical Note.

    Science.gov (United States)

    Mu, Shi-Qing; Yang, Xin-Jian; Li, You-Xiang; Jiang, Chu-Han; Wu, Zhong-Xue

    2015-07-20

    The endovascular strategy of the huge dissecting aneurysms involving the basilar artery (BA) is controversial and challenging. This study was to investigate the clinical and angiographic outcomes of the treatment of the huge dissecting aneurysms involving the BA by the internal trapping (IT) technique. We retrospectively studied 15 patients with the huge dissecting aneurysms involving the BA treated by the IT technique between September 2005 and September 2014 in Department of Interventional Neuroradiology of Beijing Tiantan Hospital. Clinical and angiographic data were reviewed and evaluated. All patients were treated by the IT technique. That meant the dissecting artery and aneurysm segments were completed occlusion. After the procedure, the angiography demonstrated that all the dissecting artery and aneurysm segments were completed occlusion. Follow-up angiography was performed at 3-6 months or 12-18 months after the endovascular treatment (median 8 months), 14 patients had a good recovery. Re-canalization occurred in one patient whose aneurysm involved in bilateral vertebral arteries and the two third of the middle-lower BA. After the second treatment, the patient died by the ventricular tachycardia. The IT technique is a technically feasible and safe alternative for the treatment of BA dissecting aneurysms, but it is not necessarily the safest or most definitive treatment modality. The ideal treatment of the huge dissecting aneurysms involving the BA remains debatable and must be investigated on a case-by-case basis.

  12. Is hepatectomy for huge hepatocellular carcinoma (≥ 10 cm in diameter) safe and effective? A single-center experience.

    Science.gov (United States)

    Yang, Jian; Li, Chuan; Wen, Tian-Fu; Yan, Lu-Nan; Li, Bo; Wang, Wen-Tao; Yang, Jia-Yin; Xu, Ming-Qing

    2014-01-01

    This retrospective study aimed to validate the safety and effectiveness of hepatectomy for huge hepatocellular carcinoma (HCC). Data of patients who underwent hepatectomy for HCC between January 2006 and December 2012 were reviewed. The patients were divided into three groups: huge HCC(≥ 10 cm in diameter), large HCC(≥ 5 buthuge and large HCC groups were lower than that of the small HCC group (OS: 32.5% vs 36.3% vs 71.2%, p=0.000; DFS: 20.0% vs 24.8% vs 40.7%, p=0.039), but there was no difference between the huge and large HCC groups (OS: 32.5% vs 36.3%, p=0.667; DFS: 20.0% vs 24.8%, p=0.540). In multivariate analysis, five independent poor prognostic factors that affected OS were significantly associated with worse survival (phuge HCC is similar to that for large and small HCC; and this approach for huge HCC may achieve similar long-term survival and disease-free survival as for large HCC.

  13. Flume tests to study the initiation of huge debris flows after the Wenchuan earthquake in S-WChina

    NARCIS (Netherlands)

    Hu, Wei; Xu, Qiang; van Asch, Theo.W.J.; Zhua, X; Xu, Q.Q.

    2014-01-01

    In the Wenchuan area in the southwest of China, a huge amount of loose co-seismic landslide material was deposited on slopes during the Wenchuan earthquake of May 2008. These loose deposits formed the source material for rainfall-induced debris flows or shallow landslides in the years after the eart

  14. A drunken search in crystallization space.

    Science.gov (United States)

    Fazio, Vincent J; Peat, Thomas S; Newman, Janet

    2014-10-01

    The REMARK280 field of the Protein Data Bank is the richest open source of successful crystallization information. The REMARK280 field is optional and currently uncurated, so significant effort needs to be applied to extract reliable data. There are well over 15 000 crystallization conditions available commercially from 12 different vendors. After putting the PDB crystallization information and the commercial cocktail data into a consistent format, these data are used to extract information about the overlap between the two sets of crystallization conditions. An estimation is made as to which commercially available conditions are most appropriate for producing well diffracting crystals by looking at which commercial conditions are found unchanged (or almost unchanged) in the PDB. Further analyses include which commercial kits are the most appropriate for shotgun or more traditional approaches to crystallization screening. This analysis suggests that almost 40% of the crystallization conditions found currently in the PDB are identical or very similar to a commercial condition.

  15. Search for extra space dimensions with ATLAS

    Indian Academy of Sciences (India)

    Ambreesh Gupta; ATLAS Collaboration

    2004-03-01

    If extra spatial dimensions were to exist, they could provide a solution to the hierarchy problem. The studies done by the ATLAS Collaboration on the sensitivity of the detector to various extra dimension models are reported in this document.

  16. Multiple-Goal Heuristic Search

    CERN Document Server

    Davidov, D; 10.1613/jair.1940

    2011-01-01

    This paper presents a new framework for anytime heuristic search where the task is to achieve as many goals as possible within the allocated resources. We show the inadequacy of traditional distance-estimation heuristics for tasks of this type and present alternative heuristics that are more appropriate for multiple-goal search. In particular, we introduce the marginal-utility heuristic, which estimates the cost and the benefit of exploring a subtree below a search node. We developed two methods for online learning of the marginal-utility heuristic. One is based on local similarity of the partial marginal utility of sibling nodes, and the other generalizes marginal-utility over the state feature space. We apply our adaptive and non-adaptive multiple-goal search algorithms to several problems, including focused crawling, and show their superiority over existing methods.

  17. Four-Dimensional Golden Search

    Energy Technology Data Exchange (ETDEWEB)

    Fenimore, Edward E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-02-25

    The Golden search technique is a method to search a multiple-dimension space to find the minimum. It basically subdivides the possible ranges of parameters until it brackets, to within an arbitrarily small distance, the minimum. It has the advantages that (1) the function to be minimized can be non-linear, (2) it does not require derivatives of the function, (3) the convergence criterion does not depend on the magnitude of the function. Thus, if the function is a goodness of fit parameter such as chi-square, the convergence does not depend on the noise being correctly estimated or the function correctly following the chi-square statistic. And, (4) the convergence criterion does not depend on the shape of the function. Thus, long shallow surfaces can be searched without the problem of premature convergence. As with many methods, the Golden search technique can be confused by surfaces with multiple minima.

  18. A Domain Specific Ontology Based Semantic Web Search Engine

    CERN Document Server

    Mukhopadhyay, Debajyoti; Mukherjee, Sreemoyee; Bhattacharya, Jhilik; Kim, Young-Chon

    2011-01-01

    Since its emergence in the 1990s the World Wide Web (WWW) has rapidly evolved into a huge mine of global information and it is growing in size everyday. The presence of huge amount of resources on the Web thus poses a serious problem of accurate search. This is mainly because today's Web is a human-readable Web where information cannot be easily processed by machine. Highly sophisticated, efficient keyword based search engines that have evolved today have not been able to bridge this gap. So comes up the concept of the Semantic Web which is envisioned by Tim Berners-Lee as the Web of machine interpretable information to make a machine processable form for expressing information. Based on the semantic Web technologies we present in this paper the design methodology and development of a semantic Web search engine which provides exact search results for a domain specific search. This search engine is developed for an agricultural Website which hosts agricultural information about the state of West Bengal.

  19. Clinicopathological profile, airway management, and outcome in huge multinodular goiters: an institutional experience from an endemic goiter region.

    Science.gov (United States)

    Agarwal, Amit; Agarwal, Sudhi; Tewari, Prabhat; Gupta, Sushil; Chand, Gyan; Mishra, Anjali; Agarwal, Gaurav; Verma, A K; Mishra, S K

    2012-04-01

    Huge goiters are common in iodine-deficient endemic regions. They are of concern to the surgeons because of the anticipated risk of difficult dissection and increased chances of surgical complications. Similarly, they are of concern to the anesthesiologists because of anticipated intubation-related difficulties and post-thyroidectomy tracheomalacia. In the present study we aimed to present our experience of managing goiters based on their gross weight, highlighting their clinicopathological profile, perioperative airway-related difficulties, and management of surgical morbidity. Retrospective analysis of patients who underwent total thyroidectomy in the primary setting at our institute from 1995 to 2009 was carried out based on the gross gland weight. The patients were thus grouped into group A: ≤200 g; group B: 201 to ≤400 g; group C: 401 to ≤600 g; group D: >600 g. Group A (660 cases); group B (108 cases); group C (36 cases); and group D (9 cases) were included. As the goiter size increased, the mean duration of goiter, compressive symptoms, retrosternal extension (RSE), airway deformity, intubation difficulty, and tracheomalacia increased. The rate of tracheostomy, sternotomy, hemorrhage, visceral injury, and hospital stay was high with huge goiters. These features were more marked in malignant goiters compared to benign goiters. However, the postoperative complications were comparable in both of those groups. Long-standing huge goiters are common in iodine-deficient endemic areas. The majority of patients have symptomatic or clinicoradiological evidence of airway involvement. The incidence of RSE, airway deformity, intubation difficulty, and tracheomalacia is high with huge goiters. The surgery is technically demanding with greater associated chances of injury to native structures. Malignancy influences the presentation and outcome in smaller goiters. In centers with experienced endocrine surgeons and dedicated anesthetists, huge goiters can be

  20. JPL Small Body Database Search Engine

    Data.gov (United States)

    National Aeronautics and Space Administration — Use this search engine to generate custom tables of orbital and/or physical parameters for all asteroids and comets (or a specified sub-set) in our small-body...

  1. User Interactive Guided Search Design Environment Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Phoenix Integration's vision is to create an intuitive human-in-the-loop engineering design environment called Guided Search that leverages recent advances in...

  2. Search-Order Independent State Caching

    DEFF Research Database (Denmark)

    Evangelista, Sami; Kristensen, Lars Michael

    2009-01-01

    State caching is a memory reduction technique used by model checkers to alleviate the state explosion problem. It has traditionally been coupled with a depth-first search to ensure termination.We propose and experimentally evaluate an extension of the state caching method for general state...... exploring algorithms that are independent of the search order (i.e., search algorithms that partition the state space into closed (visited) states, open (to visit) states and unmet states)....

  3. Search-Order Independent State Caching

    DEFF Research Database (Denmark)

    Evangelista, Sami; Kristensen, Lars Michael

    2010-01-01

    State caching is a memory reduction technique used by model checkers to alleviate the state explosion problem. It has traditionally been coupled with a depth-first search to ensure termination.We propose and experimentally evaluate an extension of the state caching method for general state...... exploring algorithms that are independent of the search order (i.e., search algorithms that partition the state space into closed (visited) states, open (to visit) states and unmet states)....

  4. Optimization of web pages for search engines

    OpenAIRE

    Harej, Anže

    2011-01-01

    The thesis describes the most important elements of a Web Page and outside factors that affect Search Engine Optimization. The basic structure of a Web page, structure and functionality of a modern Search Engine is described at the beginning. The first section deals with the start of Search Engine Optimization, including planning, analysis of web space and the selection of the most important keywords for which the site will be optimized. The next section Web Page Optimization describes...

  5. Searching for Gluinos at the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Alwall, Johan; Le, My-Phuong; Lisanti, Mariangela; Wacker, Jay G.; /SLAC /Stanford U., Phys. Dept.

    2008-03-14

    This letter describes how to perform model-independent searches for new pair-produced color octet particles that each subsequently decay into two jets plus missing energy at the Tevatron. Current searches are not sensitive to all regions of parameter space because they employ CMSSM-motivated cuts. Optimizing the H{sub T} and E{sub T} cuts expands the sensitivity of searches for all kinematically allowed decays.

  6. Web Search Engines: Search Syntax and Features.

    Science.gov (United States)

    Ojala, Marydee

    2002-01-01

    Presents a chart that explains the search syntax, features, and commands used by the 12 most widely used general Web search engines. Discusses Web standardization, expanded types of content searched, size of databases, and search engines that include both simple and advanced versions. (LRW)

  7. Web Search Engines: Search Syntax and Features.

    Science.gov (United States)

    Ojala, Marydee

    2002-01-01

    Presents a chart that explains the search syntax, features, and commands used by the 12 most widely used general Web search engines. Discusses Web standardization, expanded types of content searched, size of databases, and search engines that include both simple and advanced versions. (LRW)

  8. Space biology research development

    Science.gov (United States)

    Bonting, Sjoerd L.

    1993-01-01

    The purpose of the Search for Extraterrestrial Intelligence (SETI) Institute is to conduct and promote research related activities regarding the search for extraterrestrial life, particularly intelligent life. Such research encompasses the broad discipline of 'Life in the Universe', including all scientific and technological aspects of astronomy and the planetary sciences, chemical evolution, the origin of life, biological evolution, and cultural evolution. The primary purpose was to provide funding for the Principal Investigator to collaborate with the personnel of the SETI Institute and the NASA-Ames Research center in order to plan and develop space biology research on and in connection with Space Station Freedom; to promote cooperation with the international partners in the space station; to conduct a study on the use of biosensors in space biology research and life support system operation; and to promote space biology research through the initiation of an annual publication 'Advances in Space Biology and Medicine'.

  9. Scuba Search : when selection meets innovation

    CERN Document Server

    Verel, Sébastien; Clergue, Manuel

    2007-01-01

    We proposed a new search heuristic using the scuba diving metaphor. This approach is based on the concept of evolvability and tends to exploit neutrality in fitness landscape. Despite the fact that natural evolution does not directly select for evolvability, the basic idea behind the scuba search heuristic is to explicitly push the evolvability to increase. The search process switches between two phases: Conquest-of-the-Waters and Invasion-of-the-Land. A comparative study of the new algorithm and standard local search heuristics on the NKq-landscapes has shown advantage and limit of the scuba search. To enlighten qualitative differences between neutral search processes, the space is changed into a connected graph to visualize the pathways that the search is likely to follow.

  10. Space Acquired Photography

    Science.gov (United States)

    ,

    2008-01-01

    Interested in a photograph of the first space walk by an American astronaut, or the first photograph from space of a solar eclipse? Or maybe your interest is in a specific geologic, oceanic, or meteorological phenomenon? The U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center is making photographs of the Earth taken from space available for search, download, and ordering. These photographs were taken by Gemini mission astronauts with handheld cameras or by the Large Format Camera that flew on space shuttle Challenger in October 1984. Space photographs are distributed by EROS only as high-resolution scanned or medium-resolution digital products.

  11. Search Engine For Ebook Portal

    Directory of Open Access Journals (Sweden)

    Prashant Kanade

    2015-08-01

    Full Text Available The purpose of this paper is to establish the textual analytics involved in developing a search engine for an ebook portal. We have extracted our dataset from Project Gutenberg using a robot harvester. Textual Analytics is used for efficient search retrieval. The entire dataset is represented using Vector Space Model where each document is a vector in the vector space. Further for computational purposes we represent our dataset in the form of a Term Frequency- Inverse Document Frequency tf-idf matrix. The first step involves obtaining the most coherent sequence of words of the search query entered. The entered query is processed using Front End algorithms this includes-Spell Checker Text Segmentation and Language Modeling. Back End processing includes Similarity Modeling Clustering Indexing and Retrieval. The relationship between documents and words is established using cosine similarity measured between the documents and words in Vector Space. Clustering performed is used to suggest books that are similar to the search query entered by the user. Lastly the Lucene Based Elasticsearch engine is used for indexing on the documents. This allows faster retrieval of data. Elasticsearch returns a dictionary and creates a tf-idf matrix. The processed query is compared with the dictionary obtained and tf-idf matrix is used to calculate the score for each match to give most relevant result.

  12. Electric dipole moment searches using the isotope 129-xenon

    Energy Technology Data Exchange (ETDEWEB)

    Kuchler, Florian

    2014-11-13

    Two new complementary experiments searching for a permanent electric dipole moment (EDM) of 129-xenon are presented. Besides demonstration of a sensitivity improvement by employing established methods and a highly sensitive SQUID detection system the progress towards a novel measurement approach is discussed. The new method introduces time-varying electric fields and a liquid hyper-polarized xenon sample with a potential improvement in sensitivity of three orders of magnitude. The search for EDMs is motivated by their symmetry-breaking nature. A non-zero EDM provides a new source of CP violation to solve the mystery of the huge excess of matter over anti-matter in our Universe.

  13. Strong Production SUSY Searches at ATLAS and CMS

    CERN Document Server

    Marshall, Z L

    2015-01-01

    The results of searches for strongly-produced supersymmetry at the Large Hadron Collider by the ATLAS and CMS collaborations are presented. Several of the historically strongest zero-and one-lepton final state searches have been updated to include multi-bin fits and combinations. In addition, new two-lepton final state search results are shown from CMS and ATLAS, which show 2.6 and 3.0 standard deviation excesses, respectively, above the standard model expectation, albeit in different regions of phase space. Both collaborations have also shown new searches that cover areas uncovered by previous searches, in both searches for light stops and searches for stealth supersymmetry.

  14. Algorithms, data structures, and numerics for likelihood-based phylogenetic inference of huge trees

    Directory of Open Access Journals (Sweden)

    Izquierdo-Carrasco Fernando

    2011-12-01

    Full Text Available Abstract Background The rapid accumulation of molecular sequence data, driven by novel wet-lab sequencing technologies, poses new challenges for large-scale maximum likelihood-based phylogenetic analyses on trees with more than 30,000 taxa and several genes. The three main computational challenges are: numerical stability, the scalability of search algorithms, and the high memory requirements for computing the likelihood. Results We introduce methods for solving these three key problems and provide respective proof-of-concept implementations in RAxML. The mechanisms presented here are not RAxML-specific and can thus be applied to any likelihood-based (Bayesian or maximum likelihood tree inference program. We develop a new search strategy that can reduce the time required for tree inferences by more than 50% while yielding equally good trees (in the statistical sense for well-chosen starting trees. We present an adaptation of the Subtree Equality Vector technique for phylogenomic datasets with missing data (already available in RAxML v728 that can reduce execution times and memory requirements by up to 50%. Finally, we discuss issues pertaining to the numerical stability of the Γ model of rate heterogeneity on very large trees and argue in favor of rate heterogeneity models that use a single rate or rate category for each site to resolve these problems. Conclusions We address three major issues pertaining to large scale tree reconstruction under maximum likelihood and propose respective solutions. Respective proof-of-concept/production-level implementations of our ideas are made available as open-source code.

  15. Climate change adaptation accounting for huge uncertainties in future projections - the case of urban drainage

    Science.gov (United States)

    Willems, Patrick

    2015-04-01

    Hydrological design parameters, which are currently used in the guidelines for the design of urban drainage systems (Willems et al., 2013) have been revised, taking the Flanders region of Belgium as case study. The revision involved extrapolation of the design rainfall statistics, taking into account the current knowledge on future climate change trends till 2100. Uncertainties in these trend projections have been assessed after statistically analysing and downscaling by a quantile perturbation tool based on a broad ensemble set of climate model simulation results (44 regional + 69 global control-scenario climate model run combinations for different greenhouse gas scenarios). The impact results of the climate scenarios were investigated as changes to rainfall intensity-duration-frequency (IDF) curves. Thereafter, the climate scenarios and related changes in rainfall statistics were transferred to changes in flood frequencies of sewer systems and overflow frequencies of storage facilities. This has been done based on conceptual urban drainage models. Also the change in storage capacity required to exceed a given overflow return period, has been calculated for a range of return periods and infiltration or throughflow rates. These results were used on the basis of the revision of the hydraulic design rules of urban drainage systems. One of the major challenges while formulating these policy guidelines was the consideration of the huge uncertainties in the future climate change projections and impact assessments; see also the difficulties and pitfalls reported by the IWA/IAHR Joint Committee on Urban Drainage - Working group on urban rainfall (Willems et al., 2012). We made use of the risk concept, and found it a very useful approach to deal with the high uncertainties. It involves an impact study of the different climate projections, or - for practical reasons - a reduced set of climate scenarios tailored for the specific type of impact considered (urban floods in our

  16. SUSY searches at the LHC Run2

    CERN Document Server

    Giordano, Ferdinando

    2016-01-01

    After a period of maintenance the LHC was restarted in 2015 delivering p-p collision at a new center of mass energy of 13 TeV, this new achievement by the machine opened the phase space of many searches for physics beyond the standard model (BSM). In this talk a summary of the LHC searches for supersymmetry (SUSY) pursued by the ATLAS and CMS collaborations is presented, covering a broad number of models and scenarios. Even at this early stage the new searches greatly extend the reach of the previous Run1 analyses limiting the phase space for natural SUSY to exist.

  17. Generalized topological spaces in evolutionary theory and combinatorial chemistry.

    Science.gov (United States)

    Stadler, Bärbel M R; Stadler, Peter F

    2002-01-01

    The search spaces in combinatorial chemistry as well as the sequence spaces underlying (molecular) evolution are conventionally thought of as graphs. Recombination, however, implies a nongraphical structure of the combinatorial search spaces. These structures, and their implications for search process itself, are heretofore not well understood in general. In this contribution we review a very general formalism from point set topology and discuss its application to combinatorial search spaces, fitness landscapes, evolutionary trajectories, and artificial chemistries.

  18. GHOSTX: A Fast Sequence Homology Search Tool for Functional Annotation of Metagenomic Data.

    Science.gov (United States)

    Suzuki, Shuji; Ishida, Takashi; Ohue, Masahito; Kakuta, Masanori; Akiyama, Yutaka

    2017-01-01

    Metagenomic analysis based on whole genome shotgun sequencing data requires fast protein sequence homology searches for predicting the function of proteins coded on metagenome short reads. However, huge amounts of sequence data cause even general homology search analyses using BLASTX to become difficult in terms of computational cost. GHOSTX is a sequence homology search tool specifically developed for functional annotation of metagenome sequences. The tool is more than 160 times faster than BLASTX and has sufficient search sensitivity for metagenomic analysis. Using this tool, user can perform functional annotation of metagenomic data within a short time and infer metabolic pathways within an environment.

  19. Huge Congenital Segmental Dilatation of the Sigmoid Colon in a Neonate: A "Rarity to Meet" and a "Challenge to Treat".

    Science.gov (United States)

    Kaiser, Margarita; Castellani, Christoph; Singer, Georg; Marterer, Robert; Ratschek, Manfred; Till, Holger

    2016-01-01

    Only ten cases of neonatal congenital segmental dilatation (CSD) of the colon have been described so far. We present a full-term female newborn with trisomy 21, ventricular septal defect, and gross abdominal distension. Plain abdominal radiographs revealed a huge cystic lesion occupying the left hemiabdomen. Upon laparotomy on day 4 a CSD of the distal sigmoid and proximal rectum was confirmed and resected. The proximal colon was exteriorized and the distal part closed as a Hartmann pouch. Histology confirmed a huge segmental dilatation of the sigmoid without dysganglionosis or pseudodiverticula, but normal intestinal architecture. After correction of the ventricular septal defect a low rectal end-to-end anastomosis could be performed at an age of 5 months. The postoperative course was uneventful. CSD of the sigmoid colon is extremely "rare to meet" and a "challenge to treat" in the newborn period, but clinical awareness of this entity prompts pediatric surgical success.

  20. Surgical technique for single-port laparoscopy in huge ovarian tumors: SW Kim's technique and comparison to laparotomy.

    Science.gov (United States)

    Kim, Jeong Sook; Lee, In Ok; Eoh, Kyung Jin; Chung, Young Shin; Lee, Inha; Lee, Jung-Yun; Nam, Eun Ji; Kim, Sunghoon; Kim, Young Tae; Kim, Sang Wun

    2017-03-01

    This study aimed to introduce a method to remove huge ovarian tumors (≥15 cm) intact with single-port laparoscopic surgery (SPLS) using SW Kim's technique and to compare the surgical outcomes with those of laparotomy. Medical records were retrospectively reviewed for patients who underwent either SPLS (n=21) with SW Kim's technique using a specially designed 30×30-cm(2)-sized 3XL LapBag or laparotomy (n=22) for a huge ovarian tumor from December 2008 to May 2016. Perioperative surgical outcomes were compared. In 19/21 (90.5%) patients, SPLS was successfully performed without any tumor spillage or conversion to multi-port laparoscopy or laparotomy. There was no significant difference in patient characteristics, including tumor diameter and total operation time, between both groups. The postoperative hospital stay was significantly shorter for the SPLS group than for the laparotomy group (median, 2 [1 to 5] vs. 4 [3 to 17] days; Phuge ovarian tumors.

  1. Light WIMP search in XMASS

    Energy Technology Data Exchange (ETDEWEB)

    Abe, K. [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Kavli Institute for the Physics and Matematics of the Universe, the University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Hieda, K. [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Hiraide, K. [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Kavli Institute for the Physics and Matematics of the Universe, the University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Hirano, S. [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Kishimoto, Y.; Kobayashi, K.; Moriyama, S. [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Kavli Institute for the Physics and Matematics of the Universe, the University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Nakagawa, K. [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Nakahata, M.; Ogawa, H. [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Kavli Institute for the Physics and Matematics of the Universe, the University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Oka, N. [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Sekiya, H., E-mail: sekiya@icrr.u-tokyo.ac.jp [Kamioka Observatory, Institute for Cosmic Ray Research, the University of Tokyo, Higashi-Mozumi, Kamioka, Hida, Gifu 506-1205 (Japan); Kavli Institute for the Physics and Matematics of the Universe, the University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); and others

    2013-02-12

    A search for light dark matter using low-threshold data from the single phase liquid xenon scintillation detector XMASS, has been conducted. Using the entire 835 kg inner volume as target, the analysis threshold can be lowered to 0.3 keVee (electron-equivalent) to search for light dark matter. With low-threshold data corresponding to a 5591.4 kg day exposure of the detector and without discriminating between nuclear-recoil and electronic events, XMASS excludes part of the parameter space favored by other experiments.

  2. Using tiltmeters for early warning of tsunamis, generated by huge submarine landslides. A case study for Spitsbergen.

    OpenAIRE

    Sascha Brune; Andrey Babeyko; Stephan V. Sobolev

    2007-01-01

    A submarine landslide west of Spitsbergen could induce a destructive tsunami in the North Atlantic. Here we suggest an effective tool for early warning of tsunamis generated by huge underwater landslides. The method is based on the fact that a displacement of ~1000 km3 of sediment produces a permanent and detectable deformation of earth's lithosphere. We numerically model the ground tilting imposed by the hypothetical Spitsbergen landslide. Virtual inclinometers, positioned at the three dist...

  3. Isolated huge aneurysm of the left main coronary artery in a 22-year-old patient with type 1 neurofibromatosis.

    Science.gov (United States)

    Pontailler, Margaux; Vilarem, Didier; Paul, Jean-François; Deleuze, Philippe H

    2015-03-01

    A 22-year-old patient with neurofibromatosis type 1 presented with acute chest pain. A computed tomography scan and coronary angiography revealed a partially thrombosed huge aneurysm of the left main coronary artery. Despite medical treatment, the patient's angina recurred. The patient underwent a coronary bypass grafting operation and surgical exclusion of the aneurysm. Postoperative imaging disclosed good permeability of the 3 coronary artery bypass grafts and complete thrombosis of the excluded aneurysm.

  4. The prostatic utricle cyst with huge calculus and hypospadias: A case report and a review of the literature

    OpenAIRE

    Wang, Weigang; WANG, YUANTAO; Zhu, Dechun; Yan, Pengfei; Dong, Biao; Zhou, Honglan

    2015-01-01

    Prostatic utricle cysts with calculus and hypospadias are rare. There are a few reported cases. We present a case of a prostatic utricle cyst with huge calculus in a 25-year-old male. He had a history of left cryptorchidism and surgery for penoscrotal hypospadias in his infancy. He was referred for frequent micturition, urgency of urination, urine pain, terminal hematuria, and dysuria. A computed tomography (CT) revealed a retrovesical cystic lesion of low density, showing a 5 × 5-cm calcific...

  5. Huge Left Ventricular Thrombus and Apical Ballooning associated with Recurrent Massive Strokes in a Septic Shock Patient

    Directory of Open Access Journals (Sweden)

    Hyun-Jung Lee

    2016-02-01

    Full Text Available The most feared complication of left ventricular thrombus (LVT is the occurrence of systemic thromboembolic events, especially in the brain. Herein, we report a patient with severe sepsis who suffered recurrent devastating embolic stroke. Transthoracic echocardiography revealed apical ballooning of the left ventricle with a huge LVT, which had not been observed in chest computed tomography before the stroke. This case emphasizes the importance of serial cardiac evaluation in patients with stroke and severe medical illness.

  6. Huge saphenous vein graft aneurysm presenting as non-ST elevation myocardial infarction and compressing the heart.

    Science.gov (United States)

    Zencir, Cemil; Akpek, Mahmut; Onay, Sevil; Selvi, Mithat

    2016-09-01

    Coronary artery bypass grafting (CABG) surgery maintains an important role in the treatment of coronary artery disease. The huge saphenous vein graft aneurysm (HSVGA) is rare and occurs as a late complication after CABG. Here, we reported a case of HSVGA presenting as non-ST elevation myocardial infarction. Copyright © 2015 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  7. Long-Term Outcome After Resection of Huge Hepatocellular Carcinoma ≥ 10 cm: Single-Institution Experience with 471 Patients.

    Science.gov (United States)

    Hwang, Shin; Lee, Young-Joo; Kim, Ki-Hun; Ahn, Chul-Soo; Moon, Deok-Bog; Ha, Tae-Yong; Song, Gi-Won; Jung, Dong-Hwan; Lee, Sung-Gyu

    2015-10-01

    Tumor recurrence is very common after resection of huge hepatocellular carcinoma (HCC). This study intended to evaluate early recurrence and long-term outcomes in patients with huge HCC ≥ 10 cm after primary resection and treatment of recurrence. Recurrence and survival outcomes were retrospectively evaluated in 471 patients with huge HCCs who underwent resection between January 2000 and April 2012. Mean tumor diameter was 13.6 ± 3.1 cm, with 93 % of patients having single tumors. Anatomic and R0 resection rates were 91.1 and 89.4 %, respectively. Perioperative mortality rate was 1.7 %. Tumor recurrence and patient survival rates were 62.2 and 69.2 % at 1 year and 76.0 and 35.5 % at 5 years, respectively. Of patients with recurrence, 92.5 % received specific treatment. Median patient survival period after initial intrahepatic recurrence was 16 months. Tumor volume did not affect recurrence or survival outcomes. Independent risk factors for tumor recurrence and patient survival were serum alpha-fetoprotein ≥ 100 ng/mL, hypermetabolic uptake on positron emission tomography, satellite nodules, and microvascular invasion. These four factors were used to develop a risk prediction model, in which 1-year HCC recurrence rates in patients with 0, 1, 2, 3, and 4 risk factors were 18.7, 30.3, 58.7, 79.0, and 92.1 %, respectively, and their 1-year patient survival rates were 100, 97.0, 75.5, 63.9, and 42.1 %, respectively. In patients with huge HCCs, hepatic resection with active recurrence treatment resulted in improved long-term survival. Our 4-factor risk prediction model appears to contribute to quantitative postoperative risk estimation for early HCC recurrence and patient survival in patients with HCC ≥ 10 cm.

  8. Imbalance in systemic inflammation and immune response following transarterial chemoembolization potentially increases metastatic risk in huge hepatocellular carcinoma.

    Science.gov (United States)

    Xue, Tong-Chun; Jia, Qing-An; Ge, Ning-Ling; Chen, Yi; Zhang, Bo-Heng; Ye, Sheng-Long

    2015-11-01

    Inflammation plays a critical role in tumor metastasis. However, few inflammation-related biomarkers are currently available to predict the risk of metastasis for advanced hepatocellular carcinoma (HCC). Using huge tumors (diameter >10 cm) as a model, we evaluated the potential risk of pre- and post-treatment inflammatory responses in the development of metastasis of HCC patients undergoing transarterial chemoembolization (TACE). A logistic regression model was used to analyze the risk factors. One hundred and sixty-five patients with huge HCC were enrolled in the study. Metastases were identified in 25.5% (42/165) patients by imaging evaluation post-TACE. Neutrophils increased, whereas lymphocytes decreased significantly post-TACE. Univariate analysis showed that high post-treatment neutrophil-to-lymphocyte ratio (NLR; p = 0.003), low post-treatment lymphocyte count (p = 0.047), and high baseline NLR (p = 0.100) were potential risk factors for metastasis. Further, multivariate analysis showed that high post-treatment NLR, but not pre-treatment NLR, was an independent risk factor for metastasis; this was confirmed by receiver operating characteristic curve analysis. Post-treatment NLR, however, had no correlation to tumor response and overall survival of patients. In conclusion, post-treatment NLR but not pre-treatment NLR independently increases the risk of metastasis in huge HCC. Our findings suggest the potential contribution of treatment-related inflammation to metastasis in advanced HCC.

  9. Totally inverted cervix due to a huge prolapsed cervical myoma simulating chronic non-puerperal uterine inversion.

    Science.gov (United States)

    Turhan, Nilgun; Simavli, Serap; Kaygusuz, Ikbal; Kasap, Burcu

    2014-01-01

    Inversion of the uterus is an extremely rare complication of the non-puerperal period and is commonly caused by benign submucous, especially fundal, leiomyomas. A case of a totally inverted cervix due to a prolapsed huge cervical leiomyoma mimicking chronic non-puerperal uterine inversion in a perimenopausal woman is presented. A 52-year-old perimenopausal woman was admitted to our clinic with an ulcerated, necrotic, infected and swollen prolapsed mass. Gynecologic history revealed that she was advised myomectomy because of her cervical myoma 2 years ago but she refused to have an operation as she believed that her positive thoughts would shrink the myoma. Presumed diagnosis before surgery was chronic non-puerperal uterine inversion. An intraoperative diagnosis was totally inverted cervix due to a huge cervical leiomyoma. Vaginal hysterectomy without adnexectomy, was performed. This is the first case in the literature which a totally inverted cervix due to a prolapsed huge cervical leiomyoma. Cervical fibroids can grow in perimenopausal period and in extremely rare cases can cause total cervical inversion. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  10. [Analysis of efficacy and prognostic factors of transarterial chemoembolization combined with multimodality therapy for huge hepatocellular carcinoma].

    Science.gov (United States)

    Chang, Zhongfei; Wang, Maoqiang; Liu, Fengyong; Duan, Feng; Wang, Zhijun; Song, Peng

    2014-01-01

    The aim of this study was to evaluate the efficacy, survival and prognosis of transarterial chemoembolization (TACE) alone and TACE in combination with multimodality therapy for huge hepatocellular carcinoma. A retrospective analysis was conducted in 115 patients with huge hepatocellular carcinoma treated in our hospital from August 2008 to January 2012. Among them, 72 patients were treated by TACE alone (TACE group) and 43 patients by TACE plus multimodality therapy (TACE-combined treatment group). Their clinicopathological data and survival were analyzed. The median follow-up of the 115 cases was 24 months (range 1-40 months). The 1-, 2-, and 3-year overall survival (OS) rates for the TACE group were 60.4,% 23.3% and 9.8%, respectively, and 39 months, 78.1%, 43.3% and 36.8%, respectively, for the combined treatment group (P 0.05 for all), while multimodality therapy, Child's grading, ECOG scores, distant metastasis, and portal vein tumor thrombus were significantly related to the overall survival. Moreover, the Cox multivariate survival analysis revealed that therapy and ECOG scores were independent prognostic indicators (P huge hepatocellular carcinoma. Multimodality therapy and ECOG scores are independent prognostic indicators for the patients.

  11. Query Recommendation by Coupling Personalization with Clustering for Search Engine

    Directory of Open Access Journals (Sweden)

    Dhiliphanrajkumar.Thambidurai

    2016-11-01

    Full Text Available In the present world internet and web search engines have become an important part in one’s day-today life. For a user query, more than few thousand web pages are retrieved but most of them are irrelevant. A major problem in search engine is that the user queries are usually short and ambiguous, and they are not sufficient to satisfy the precise user needs. Also listing more number of results according to user make them worry about searching the desired results and it takes large amount of time to search from the huge list of results. To overcome all the problems, an effective approach is developed by capturing the users’ click through and bookmarking data to provide personalized query recommendation. For retrieving the results, Google API is used. Experimental results show that the proposed method is providing better query recommendation results than the existing query suggestion methods.

  12. Personalized Search Based on Context-Centric Model

    Directory of Open Access Journals (Sweden)

    Mingyang Liu

    2013-07-01

    Full Text Available With the rapid development of the World Wide Web, huge amount of data has been growing exponentially in our daily life. Users will spend much more time on searching the information they really need than before. Even when they make the exactly same searching input, different users would have various goals. Otherwise, users commonly annotate the information resources or make search query according to their own behaviors. As a matter of fact, this process will bring fuzzy results and be time-consuming. Based on the above problems, we propose our methodology that to combine user’s context, users’ profile with users’ Folksonomies together to optimize personal search. At the end of this paper, we make an experiment to evaluate our methodology and from which we can conclude that our work performs better than other samples.

  13. Genetic risk factors for placental abruption: a HuGE review and meta-analysis.

    Science.gov (United States)

    Zdoukopoulos, Nikos; Zintzaras, Elias

    2008-03-01

    Although the precise pathophysiology that leads to placental abruption is unknown, there is evidence supporting a genetic etiology. We searched PubMed and systematically reviewed all case-control studies that investigated the association between genetic variants and placental abruption. Pooled genetic risks were estimated using fixed and random effects odds ratios. Twenty-two articles, examining a total of 14 gene polymorphisms were identified. Seven polymorphisms (F5 Arg506Gln, F5 Met385Thr, F2 G20210A, MTHFR A1298C, MTHFD1 Arg653Gln, NOS3 Glu298Asp, AGT Met235Thr) show significant association in individual studies. Six of the 7 (all except F5Met385Thr) were studied more than once and we therefore included them in our meta-analyses. A positive association under the dominant model was found for the F5 Arg506Gln and F2 G20210A polymorphisms. The random-effects odds ratio for the F5 Arg506Gln polymorphism was 3.4 (95% confidence interval = 1.4-8.3) and the fixed-effects odds ratio for the F2 G20210A polymorphism was 6.7 (3.2-13). Considering the multifactorial etiology of abruption and the relatively small numbers of studies and participants, this review provides only the first clues of possible genetic causes. Larger case-control studies that include gene-gene and gene-environment interactions may help to elucidate the genetics of placental abruption further.

  14. Foraging in Semantic Fields: How We Search Through Memory.

    Science.gov (United States)

    Hills, Thomas T; Todd, Peter M; Jones, Michael N

    2015-07-01

    When searching for concepts in memory--as in the verbal fluency task of naming all the animals one can think of--people appear to explore internal mental representations in much the same way that animals forage in physical space: searching locally within patches of information before transitioning globally between patches. However, the definition of the patches being searched in mental space is not well specified. Do we search by activating explicit predefined categories (e.g., pets) and recall items from within that category (categorical search), or do we activate and recall a connected sequence of individual items without using categorical information, with each item recalled leading to the retrieval of an associated item in a stream (associative search), or both? Using semantic representations in a search of associative memory framework and data from the animal fluency task, we tested competing hypotheses based on associative and categorical search models. Associative, but not categorical, patch transitions took longer to make than position-matched productions, suggesting that categorical transitions were not true transitions. There was also clear evidence of associative search even within categorical patch boundaries. Furthermore, most individuals' behavior was best explained by an associative search model without the addition of categorical information. Thus, our results support a search process that does not use categorical information, but for which patch boundaries shift with each recall and local search is well described by a random walk in semantic space, with switches to new regions of the semantic space when the current region is depleted.

  15. Progress control in iterated local search for nurse rostering

    NARCIS (Netherlands)

    Burke, E.K.; Curtois, T.; Fijn van Draat, L.; van Ommeren, Jan C.W.; Post, Gerhard F.

    2011-01-01

    This paper describes an approach in which a local search technique is alternated with a process which ‘jumps’ to another point in the search space. After each ‘jump’ a (time-intensive) local search is used to obtain a new local optimum. The focus of the paper is in monitoring the progress of this te

  16. Google Ajax Search API

    CERN Document Server

    Fitzgerald, Michael

    2007-01-01

    Use the Google Ajax Search API to integrateweb search, image search, localsearch, and other types of search intoyour web site by embedding a simple, dynamicsearch box to display search resultsin your own web pages using a fewlines of JavaScript. For those who do not want to write code,the search wizards and solutions builtwith the Google Ajax Search API generatecode to accomplish common taskslike adding local search results to a GoogleMaps API mashup, adding videosearch thumbnails to your web site, oradding a news reel with the latest up todate stories to your blog. More advanced users can

  17. A huge reservoir of ionized gas around the Milky Way: Accounting for the Missing Mass?

    CERN Document Server

    Gupta, A; Krongold, Y; Nicastro, F; Galeazzi, M

    2012-01-01

    Most of the baryons from galaxies have been "missing" and several studies have attempted to map the circumgalactic medium (CGM) of galaxies in their quest. Recent studies with the Hubble Space Telescope have shown that many galaxies contain a large reservoir of ionized gas with temperatures of about 10^5 K. Here we report on X-ray observations made with the Chandra X-ray Observatory probing an even hotter phase of the CGM of our Milky Way at about 10^6 K. We show that this phase of the CGM is massive, extending over a large region around the Milky Way, with a radius of over 100 kpc. The mass content of this phase is over ten billion solar masses, many times more than that in cooler gas phases and comparable to the total baryonic mass in the disk of the Galaxy. The missing mass of the Galaxy appears to be in this warm-hot gas phase.

  18. Mirador: A Simple, Fast Search Interface for Remote Sensing Data

    Science.gov (United States)

    Lynnes, Christopher; Strub, Richard; Seiler, Edward; Joshi, Talak; MacHarrie, Peter

    2008-01-01

    A major challenge for remote sensing science researchers is searching and acquiring relevant data files for their research projects based on content, space and time constraints. Several structured query (SQ) and hierarchical navigation (HN) search interfaces have been develop ed to satisfy this requirement, yet the dominant search engines in th e general domain are based on free-text search. The Goddard Earth Sci ences Data and Information Services Center has developed a free-text search interface named Mirador that supports space-time queries, inc luding a gazetteer and geophysical event gazetteer. In order to compe nsate for a slightly reduced search precision relative to SQ and HN t echniques, Mirador uses several search optimizations to return result s quickly. The quick response enables a more iterative search strateg y than is available with many SQ and HN techniques.

  19. Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study.

    Science.gov (United States)

    Zhong, Nan Bao; Lv, Guang Ming; Chen, Zhong Hua

    2014-09-01

    This study was conducted to evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) combined with transarterial chemoembolization (TACE) for huge (≥10 cm) hepatocellular carcinomas (HCCs). Between May, 2006 and December, 2012, 72 patients with huge HCCs were treated by SBRT following incomplete TACE. The median total dose of 35.6 Gy was delivered over 12-14 days with a fractional dose of 2.6-3.0 Gy and 6 fractions per week. The patients were classified into those with tumor encapsulation (group A, n=33) and those without tumor encapsulation (group B, n=39). The clinical outcomes of tumor response, overall cumulative survival and toxicities/complications were retrospectively analyzed. Among the 72 patients, CR, PR, SD and PD were achieved in 6 (8.3%), 51 (70.8%), 9 (12.5%) and 6 patients (8.3%), respectively, within a median follow-up of 18 months. The objective response rate was 79.1%. The overall cumulative 1-, 3- and 5-year survival rates and the median survival time were 38, 12 and 3% and 12.2 months, respectively. In group A, the overall cumulative 1-, 3- and 5-year survival rates were 56, 21 and 6%, respectively, with a median survival of 19 months; in group B, the overall cumulative 1-, 3- and 5-year survival rates were 23, 4 and 0%, respectively, with a median survival of 10.8 months (P=0.023). The treatment was well tolerated, with no severe radiation-induced liver disease and no reported > grade 3 toxicity. Tumor encapsulation was found to be a significant prognostic factor for survival. In conclusion, the combination of SBRT and TACE was shown to be a safe and effective treatment option for patients with unresectable huge HCC.

  20. HUBBLE REVEALS HUGE CRATER ON THE SURFACE OF THE ASTEROID VESTA

    Science.gov (United States)

    2002-01-01

    [left] A NASA Hubble Space Telescope image of the asteroid Vesta, taken in May 1996 when the asteroid was 110 million miles from Earth. The asymmetry of the asteroid and 'nub' and the south pole is suggestive that it suffered a large impact event. The image was digitally restored to yield an effective scale of six miles per pixel (picture element). [center] A color-encoded elevation map of Vesta clearly shows the giant 285- mile diameter impact basin and 'bull's-eye' central peak. The map was constructed from 78 Wide Field Planetary Camera 2 pictures. Surface topography was estimated by noting irregularities along the limb and at the terminator (day/night boundary) where shadows are enhanced by the low Sun angle. [right] A 3-D computer model of the asteroid Vesta synthesized from Hubble topographic data. The crater's 8-mile high central peak can clearly be seen near the pole. The surface texture on the model is artificial, and is not representative of the true brightness variations on the asteroid. Elevation features have not been exaggerated. Photo Credit: Ben Zellner (Georgia Southern University), Peter Thomas (Cornell University), NASA