Replicated population divergence caused by localized coevolution? A test of three hypotheses in the red crossbill-lodgepole pine system.

Science.gov (United States)

Edelaar, P; Benkman, C W

2006-09-01

Several lines of evidence support the hypothesis that local populations of red crossbills (Loxia curvirostra complex) enter into a predator-prey arms race with lodgepole pine (Pinus contorta latifolia) in the absence of competing pine squirrels (Tamiasciurus hudsonicus). Nevertheless, the alternative hypotheses that neutral evolution or factors other than squirrels have caused crossbill population differentiation have not been thoroughly tested. We compared crossbill and pine cone morphology between island populations where squirrels are absent or present, and mainland sites where squirrels are present, in order to distinguish among these hypotheses. All comparisons supported an effect of squirrel absence, not island status, on crossbill and cone morphology. Hence our results provide further evidence that strong localized coevolutionary interactions in a geographic mosaic have driven adaptive population differentiation. In addition, vocal differentiation of crossbills was related to the absence of squirrels, but not to island status. As morphological and vocal differentiation is correlated with reproductive isolation in crossbills, the geographic mosaic of coevolution also seems to promote ecological speciation.

Reproductive phenology of a food-hoarding mast-seed consumer: resource- and density-dependent benefits of early breeding in red squirrels.

Science.gov (United States)

Williams, Cory T; Lane, Jeffrey E; Humphries, Murray M; McAdam, Andrew G; Boutin, Stan

2014-03-01

The production of offspring by vertebrates is often timed to coincide with the annual peak in resource availability. However, capital breeders can extend the energetic benefits of a resource pulse by storing food or fat, thus relaxing the need for synchrony between energy supply and demand. Food-hoarding red squirrels (Tamiasciurus hudsonicus) breeding in the boreal forest are reliant on cones from a masting conifer for their nutrition, yet lactation is typically completed before the annual crop of cones is available for consumption such that peaks in energy supply and demand are not synchronized. We investigated the phenological response of red squirrels to annual variation in environmental conditions over a 20-year span and examined how intra- and inter-annual variation in the timing of reproduction affected offspring recruitment. Reproductive phenology was strongly affected by past resource availability with offspring born earlier in years following large cone crops, presumably because this affected the amount of capital available for reproduction. Early breeders had higher offspring survival and were more likely to renest following early litter loss when population density was high, perhaps because late-born offspring are less competitive in obtaining a territory when vacancies are limited. Early breeders were also more likely to renest after successfully weaning their first litter, but renesting predominantly occurred during mast years. Because of their increased propensity to renest and the higher survival rates of their offspring, early breeders contribute more recruits to the population but the advantage of early breeding depends on population density and resource availability.

Powassan Virus: Persistence of Virus Activity During 1966

Science.gov (United States)

McLean, Donald M.; Cobb, Cathron; Gooderham, Susan E.; Smart, Carol A.; Wilson, A. G.; Wilson, W. E.

1967-01-01

Powassan virus isolations were achieved from three of 60 pools of Ixodes cookei ticks removed from 286 groundhogs (Marmota monax) which were collected some 200 miles north of Toronto between May 5 and September 5, 1966. Virus yields per pool of one to 11 ticks ranged from 102.5 to 106.0 TCD50 for primary swine kidney tissue cultures, and positive pools were collected on June 24, July 15 and August 10. Powassan neutralizing antibodies were detected by mouse inoculation tests in 143 of 362 animals including 127 of 286 groundhogs, 14 of 45 red squirrels (Tamiasciurus hudsonicus) and two of 31 other forest mammals. The monthly prevalence of antibody in the current season's groundhogs increased from 0 to 25% with the progression of summer, but in older animals the incidence remained between 38 and 62% throughout the season. These results substantiate earlier findings which pointed towards the maintenance of Powassan virus in nature by a cycle involving groundhogs and squirrels as reservoirs, with ticks as vectors, from which human infections occurred tangentially. PMID:6019677

Responsibility and Responsiveness

DEFF Research Database (Denmark)

Nissen, Ulrik Becker

2011-01-01

The debate on the role and identity of Christian social ethics in liberal democracy touches upon the question about the relationship between universality and speci-ficity. Rather than argue for the difference between these approaches, it can be argued that they are to be understood in a different......The debate on the role and identity of Christian social ethics in liberal democracy touches upon the question about the relationship between universality and speci-ficity. Rather than argue for the difference between these approaches, it can be argued that they are to be understood...... contemporary positions of communicative ethics, H. Richard Niebuhr’s understanding of responsibility as responsiveness, and Dietrich Bonhoeffer’s Christological concept of responsibility in a constructive dialogue with each other, the article has attempted to outline main tenets of a responsive concept...

Ecological consequences of mountain pine beetle outbreaks for wildlife in western North American forests

Science.gov (United States)

Saab, Victoria A.; Latif, Quresh S.; Rowland, Mary M.; Johnson, Tracey N.; Chalfoun, Anna D.; Buskirk, Steven W.; Heyward, Joslin E.; Dresser, Matthew A.

2014-01-01

outbreaks on red squirrels (Tamiasciurus hudsonicus). However, there is evidence that red squirrels can persist after an outbreak under some conditions, e.g., when nonhost tree species are present. For small mammal species associated with forest understories, responses may be most pronounced during the postepidemic period (>6 years after the peak of beetle-induced tree mortality) when snags fall to produce coarse woody debris. Postoutbreak salvage logging studies (n = 6) reported results that lacked consensus. Postoutbreak salvage logging may have an impact on fewer wildlife species than postfire salvage logging, probably because only host-specific tree species are removed after beetle outbreaks.

Relational responsibilities in responsive evaluation

NARCIS (Netherlands)

Visse, M.A.; Abma, T.A.; Widdershoven, G.A.M.

2012-01-01

This article explores how we can enhance our understanding of the moral responsibilities in daily, plural practices of responsive evaluation. It introduces an interpretive framework for understanding the moral aspects of evaluation practice. The framework supports responsive evaluators to better

Hidden Markov Item Response Theory Models for Responses and Response Times.

Science.gov (United States)

Molenaar, Dylan; Oberski, Daniel; Vermunt, Jeroen; De Boeck, Paul

2016-01-01

Current approaches to model responses and response times to psychometric tests solely focus on between-subject differences in speed and ability. Within subjects, speed and ability are assumed to be constants. Violations of this assumption are generally absorbed in the residual of the model. As a result, within-subject departures from the between-subject speed and ability level remain undetected. These departures may be of interest to the researcher as they reflect differences in the response processes adopted on the items of a test. In this article, we propose a dynamic approach for responses and response times based on hidden Markov modeling to account for within-subject differences in responses and response times. A simulation study is conducted to demonstrate acceptable parameter recovery and acceptable performance of various fit indices in distinguishing between different models. In addition, both a confirmatory and an exploratory application are presented to demonstrate the practical value of the modeling approach.

Response moderation models for conditional dependence between response time and response accuracy.

Science.gov (United States)

Bolsinova, Maria; Tijmstra, Jesper; Molenaar, Dylan

2017-05-01

It is becoming more feasible and common to register response times in the application of psychometric tests. Researchers thus have the opportunity to jointly model response accuracy and response time, which provides users with more relevant information. The most common choice is to use the hierarchical model (van der Linden, 2007, Psychometrika, 72, 287), which assumes conditional independence between response time and accuracy, given a person's speed and ability. However, this assumption may be violated in practice if, for example, persons vary their speed or differ in their response strategies, leading to conditional dependence between response time and accuracy and confounding measurement. We propose six nested hierarchical models for response time and accuracy that allow for conditional dependence, and discuss their relationship to existing models. Unlike existing approaches, the proposed hierarchical models allow for various forms of conditional dependence in the model and allow the effect of continuous residual response time on response accuracy to be item-specific, person-specific, or both. Estimation procedures for the models are proposed, as well as two information criteria that can be used for model selection. Parameter recovery and usefulness of the information criteria are investigated using simulation, indicating that the procedure works well and is likely to select the appropriate model. Two empirical applications are discussed to illustrate the different types of conditional dependence that may occur in practice and how these can be captured using the proposed hierarchical models. © 2016 The British Psychological Society.

DNA damage response pathway in radioadaptive response.

Science.gov (United States)

Sasaki, Masao S; Ejima, Yosuke; Tachibana, Akira; Yamada, Toshiko; Ishizaki, Kanji; Shimizu, Takashi; Nomura, Taisei

2002-07-25

Radioadaptive response is a biological defense mechanism in which low-dose ionizing irradiation elicits cellular resistance to the genotoxic effects of subsequent irradiation. However, its molecular mechanism remains largely unknown. We previously demonstrated that the dose recognition and adaptive response could be mediated by a feedback signaling pathway involving protein kinase C (PKC), p38 mitogen activated protein kinase (p38MAPK) and phospholipase C (PLC). Further, to elucidate the downstream effector pathway, we studied the X-ray-induced adaptive response in cultured mouse and human cells with different genetic background relevant to the DNA damage response pathway, such as deficiencies in TP53, DNA-PKcs, ATM and FANCA genes. The results showed that p53 protein played a key role in the adaptive response while DNA-PKcs, ATM and FANCA were not responsible. Wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), mimicked the priming irradiation in that the inhibitor alone rendered the cells resistant against the induction of chromosome aberrations and apoptosis by the subsequent X-ray irradiation. The adaptive response, whether it was afforded by low-dose X-rays or wortmannin, occurred in parallel with the reduction of apoptotic cell death by challenging doses. The inhibitor of p38MAPK which blocks the adaptive response did not suppress apoptosis. These observations indicate that the adaptive response and apoptotic cell death constitute a complementary defense system via life-or-death decisions. The p53 has a pivotal role in channeling the radiation-induced DNA double-strand breaks (DSBs) into an adaptive legitimate repair pathway, where the signals are integrated into p53 by a circuitous PKC-p38MAPK-PLC damage sensing pathway, and hence turning off the signals to an alternative pathway to illegitimate repair and apoptosis. A possible molecular mechanism of adaptive response to low-dose ionizing irradiation has been discussed in relation to

Corporate Responsibility

DEFF Research Database (Denmark)

Waddock, Sandra; Rasche, Andreas

2015-01-01

We define and discuss the concept of corporate responsibility. We suggest that corporate responsibility has some unique characteristics, which makes it different from earlier conceptions of corporate social responsibility. Our discussion further shows commonalities and differences between corporate...... responsibility and related concepts, such as corporate citizenship and business ethics. We also outline some ways in which corporations have implemented corporate responsibility in practice....

Self-Responsibility and Responsibility for Others

Directory of Open Access Journals (Sweden)

Philip Buckley

2016-09-01

Full Text Available Because of the transcendent nature of the experience of my own self, responsibility for myself necessarily leads to responsibility for others. The aim of this paper is to approach this experience of the transcendence of the self and to show how it relates to a new sense of responsibility which transcends the self through a number of stages. First, the author outlines what might be called the "standard" view of authenticity in Husserl and how this particular view yields a certain view of responsibility as the ability to answer completely for "who" one is and "what" one does. Second, this standard view is challenged with another reading of the "self" in Husserl – one that emphasizes a necessary and productive division within the self. Thus, the author suggests that it is this second view of the self which is developed by Heidegger. Third, he demonstrates how this different view of the "authentic" self, that is inextricably linked to a "loss" of self, leads to a radically distinct view of responsibility for oneself, and for others.

Corporate Responsibility

OpenAIRE

World Bank

2004-01-01

Appeals to corporate responsibility often simply take for granted that businesses have ethical responsibilities that go beyond just respecting the law. This paper addresses arguments to the effect that businesses have no such responsibilities. The interesting claim is not that businesses have no ethical responsibility at all but that their primal responsibility is to increase their profits. The extent to which there is reason to take such arguments seriously delineates the limits of corporate...

Responsibility for what? Fairness and individual responsibility

OpenAIRE

Cappelen, Alexander Wright; Sørensen, Erik Øiolf; Tungodden, Bertil

2010-01-01

-This is the author's version of the article: "Responsibility for what? Fairness and individual responsibility", European Economic Review, Volume 54, Issue 3, April 2010, Pages 429–441. What should individuals be held responsible for? This is a fundamental question in much of the contemporary debate on distributive justice. Different fairness ideals, such as strict egalitarianism, and different versions of equal opportunity ethics and libertarianism give different answers to this question....

Responsible geographies and geographies of response

DEFF Research Database (Denmark)

Grindsted, Thomas Skou

This dissertation engages with Danish University geographers at work and their explication of the role of geography in shaping socio-environmental debates in an era of the anthropocene. Situating sustainability concepts in a historygeographical context the dissertation examines responses and resp......This dissertation engages with Danish University geographers at work and their explication of the role of geography in shaping socio-environmental debates in an era of the anthropocene. Situating sustainability concepts in a historygeographical context the dissertation examines responses...... in higher education literature. The methodological framework is based on the social nature approach that tangles these quite distinct epistemological communities by consulting the socio-natures produced. It is concluded that though geographers find sustainability themes important to geography......, sustainability is more often implicit than it is explicit. This produces a number of dilemmas and contradictions since geographers both seek to distance themselves from produced politics while at the same time elucidating them. Geographies of response and responsibilities address the battleground over...

Responsible drinking

Science.gov (United States)

Alcohol use disorder - responsible drinking; Drinking alcohol responsibly; Drinking in moderation; Alcoholism - responsible drinking ... 2016. National Institute on Alcohol Abuse and Alcoholism. Alcohol use disorder. www.niaaa.nih.gov/alcohol-health/overview-alcohol- ...

A role for habitat area in the geographic mosaic of coevolution between red crossbills and lodgepole pine.

Science.gov (United States)

Siepielski, A M; Benkman, C W

2005-07-01

Understanding how resource abundance limits adaptive evolution and influences species interactions is an important step towards developing insight into the role of microevolutionary processes in establishing macroevolutionary patterns. We examined how variation in resource abundance (forest area of lodgepole pine Pinus contorta ssp. latifolia) influenced patterns of co-adaptation and coevolution between red crossbill (Loxia curvirostra complex) and lodgepole pine populations. First, we found that crossbill abundance increased logarithmically as forest area increased in mountain ranges lacking a preemptive competitor (pine squirrels Tamiasciurus hudsonicus). Second, seed defences against predation by crossbills increased with increases in crossbill density, suggesting that seed defences have likely evolved in proportion to the intensity of selection that crossbills exert. Third, the average bill size of crossbill populations increased with increasing seed defences, which implies that crossbill offenses increased with increases in seed defences. The large bill size on the largest range is the result of coevolution with lodgepole pine with this crossbill population perhaps speciating. Local adaptation of crossbill populations on smaller ranges, however, is more likely the result of resident crossbills representing a subset of the potential colonists (phenotypic sorting) than of local evolution. In the smallest range, migration and possibly more frequent extinction likely impede local adaptation and may result in maladaptation.

Technology and responsibility

International Nuclear Information System (INIS)

Zimmerli, W.C.

1987-01-01

Philosophical reflections on the concepts of responsibility and type of responsibility are presented and discussed with regard to the developments of technology. The author states that neither the relationship between liability and responsibility has changed, nor the structure of responsibility. Any individual still is responsible for his actions and their consequences. What has changed, however, is the former restriction to the concept of internal responsibility and the overlapping of acting subject and responsible subject. (DG) [de

Responsibility navigator

NARCIS (Netherlands)

Kuhlmann, Stefan; Edler, Jakob; Ordonez Matamoros, Hector Gonzalo; Randles, Sally; Walhout, Bart; Walhout, Bart; Gough, Clair; Lindner, Ralf; Lindner, Ralf; Kuhlmann, Stefan; Randles, Sally; Bedsted, Bjorn; Gorgoni, Guido; Griessler, Erich; Loconto, Allison; Mejlgaard, Niels

2016-01-01

Research and innovation activities need to become more responsive to societal challenges and concerns. The Responsibility Navigator, developed in the Res-AGorA project, supports decision-makers to govern such activities towards more conscious responsibility. What is considered “responsible” will

Playful hyper responsibility

DEFF Research Database (Denmark)

Knudsen, Hanne; Andersen, Niels Åkerstrøm

2014-01-01

Over the past 10–15 years, state-funded schools have begun to require parents to assume an undefined and infinite personal responsibility. In this article, we investigate how schools organize responsibility games to respond to this challenge and how these games affect the concept of responsibility....... We point to a dislocation in the way parents are assigned responsibility, because the definition of responsibility is not only a question of formulating rules or providing advice. We argue that what emerges is a kind of playful hyper responsibility that identifies responsibility as the participation...

Query responses

Directory of Open Access Journals (Sweden)

Paweł Łupkowski

2017-05-01

Full Text Available In this article we consider the phenomenon of answering a query with a query. Although such answers are common, no large scale, corpus-based characterization exists, with the exception of clarification requests. After briefly reviewing different theoretical approaches on this subject, we present a corpus study of query responses in the British National Corpus and develop a taxonomy for query responses. We point at a variety of response categories that have not been formalized in previous dialogue work, particularly those relevant to adversarial interaction. We show that different response categories have significantly different rates of subsequent answer provision. We provide a formal analysis of the response categories in the framework of KoS.

Caregiver Responsiveness to the Family Bereavement Program: What predicts responsiveness? What does responsiveness predict?

OpenAIRE

Schoenfelder, Erin N.; Sandler, Irwin N.; Millsap, Roger E.; Wolchik, Sharlene A.; Berkel, Cady; Ayers, Timothy S.

2013-01-01

The study developed a multi-dimensional measure to assess participant responsiveness to a preventive intervention, and applied this measure to study how participant baseline characteristics predict responsiveness and how responsiveness predicts program outcomes. The study was conducted with caregivers who participated in the parenting-focused component of the Family Bereavement Program (FBP), a prevention program for families that have experienced parental death. The sample consisted of 89 ca...

Optimal Responsible Investment

DEFF Research Database (Denmark)

Jessen, Pernille

The paper studies retail Socially Responsible Investment and portfolio allocation. It extends conventional portfolio theory by allowing for a personal value based investment decision. When preferences for responsibility enter the framework for mean-variance analysis, it yields an optimal...... responsible investment model. An example of index investing illustrates the theory. Results show that it is crucial for the responsible investor to consider portfolio risk, expected return, and responsibility simultaneously in order to obtain an optimal portfolio. The model enables responsible investors...

Responsible nations

DEFF Research Database (Denmark)

Lippert-Rasmussen, Kasper

2009-01-01

In National Responsibility and Global Justice, David Miller defends the view that a member of a nation can be collectively responsible for an outcome despite the fact that: (i) she did not control it; (ii) she actively opposed those of her nation's policies that produced the outcome; and (iii......) actively opposing the relevant policy was costly for her. I argue that Miller's arguments in favor of this strong externalist view about responsibility and control are insufficient. Specifically, I show that Miller's two models of synchronic collective responsibility*the like-minded group model...

Dissociating stimulus-stimulus and response-response effects in the Stroop task

OpenAIRE

Schmidt, James; Cheesman, J

2005-01-01

The separate semantic and response competition interactions between colour and word processing in a manual Stroop task were evaluated by comparing three trial types. Identity trials are both semantically compatible and response compatible (e.g., BLUE in the colour blue), different response trials are both semantically incompatible and response incompatible (e.g., BLUE in the colour green, where blue and green have different response keys), and same response trials are semantically incompatibl...

Response Mixture Modeling: Accounting for Heterogeneity in Item Characteristics across Response Times.

Science.gov (United States)

Molenaar, Dylan; de Boeck, Paul

2018-06-01

In item response theory modeling of responses and response times, it is commonly assumed that the item responses have the same characteristics across the response times. However, heterogeneity might arise in the data if subjects resort to different response processes when solving the test items. These differences may be within-subject effects, that is, a subject might use a certain process on some of the items and a different process with different item characteristics on the other items. If the probability of using one process over the other process depends on the subject's response time, within-subject heterogeneity of the item characteristics across the response times arises. In this paper, the method of response mixture modeling is presented to account for such heterogeneity. Contrary to traditional mixture modeling where the full response vectors are classified, response mixture modeling involves classification of the individual elements in the response vector. In a simulation study, the response mixture model is shown to be viable in terms of parameter recovery. In addition, the response mixture model is applied to a real dataset to illustrate its use in investigating within-subject heterogeneity in the item characteristics across response times.

PENGARUH PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY TERHADAP EARNING RESPONSE COEFFICIENT

Directory of Open Access Journals (Sweden)

MI Mitha Dwi Restuti

2012-03-01

Full Text Available Tujuan penelitian ini adalah untuk mengetahui pengaruh negatif pengungkapan Corporate Sosial Responsibility (CSR disclosure terhadap Earning Response Coefficient (ERC. Alat analisis yang digunakan dalam penelitian ini menggunakan metode analisis regresi berganda.Sampel yang digunakan adalah sebanyak 150 perusahaan yang terdaftar pada Bursa Efek Indonesia pada tahun 2010. Berdasarkan hasil penelitian ditemukan bahwa pengungkapan Corporate Social Responsibility tidak berpengaruh terhadap Earning Response Coefficient (ERC. Hal ini dapat dikatakan bahwa investor belum memperhatikan informasi-informasi sosial yang diungkapkan dalam laporan tahunan perusahaan sebagai informasi yang dapat mempengaruhi investor dalam melakukan keputusan investasi. Investor masih mengganggap informasi laba lebih bermanfaat dalam menilai perusahaan dan dianggap lebih mampu memberikan informasi untuk mendapatkan return saham yang diharapkan oleh investor dibandingkan dengan informasi sosial yang diungkapkan oleh perusahaan.The purpose of this study is to determine the negative effect of Corporate Social Responsibility disclosure (CSR disclosure of Earnings Response Coefficient (ERC. Multiple regressions were used to analyze the data. The samples were 150 companies listed on the Indonesia Stock Exchange in 2010. Based on the research, the result was the disclosures of Corporate Social Responsibility did not influence Earning Response Coefficient (ECR. It can be said that investors did not pay attention to social information that was disclosed in the company’s annual report as information that could affect investors in making investment decisions. Investor did not consider sosial information; they only consider profit information to assess the company value and their investment return

Optimal Responsible Investment

DEFF Research Database (Denmark)

Jessen, Pernille

Numerous institutions are now engaged in Socially Responsible Investment or have signed the "UN Principles for Responsible Investment". Retail investors, however, are still lacking behind. This is peculiar since the sector constitutes key stakeholders in environmental, social and governmental...... standards. This paper considers optimal responsible investment for a small retail investor. It extends conventional portfolio theory by allowing for a personal-value based investment decision. Preferences for responsibility are defined in the framework of mean-variance analysis and an optimal responsible...... investment model identified. Implications of the altered investment problem are investigated when the dynamics between portfolio risk, expected return and responsibility is considered. Relying on the definition of a responsible investor, it is shown how superior investment opportunities can emerge when...

Spill response exercises and lessons learned : a response organization's perspective

International Nuclear Information System (INIS)

Taylor, E.; Green, M.

2001-01-01

In the past five years, Burrard Clean Operations (BCO) has demonstrated its' oil spill response capabilities through different types of exercises. Such exercises are necessary for certification of Response Organizations in Canada. The exercises can be performed through actual response to spills or through simulated situations. Both can provide an opportunity to practice different levels of response to a range of conditions in various settings. They also provide the opportunity to focus on specific themes that can be part of a response and to identify areas for improvement in response actions. They also make it possible to interface with government agencies, industry and others that participate in spill responses. The exercise program for BCO is aimed at maintaining certification and to assist the Canadian Coast Guard. The exercises broaden the lessons learned and set a course for future enhancement to spill readiness should a real incident occur. The goals of the exercise program are to provide real time drills that show the operational capability of a representative sample of BCO equipment, management and trained spill responders. The response functions of the BCO exercise program are: notification, response organization activation, contractor activation, situation analysis, strategy development for marine oil spill response, site safety, equipment deployment, containment, recovery, shoreline assessment, cleanup, communications, decontamination, logistics, and financial management. The BCO experience has led to the basic conclusions that there is a need to vary the exercise design and format and that there is a need to implement follow-up actions provided during exercise evaluations. 7 refs., 3 tabs

Seismic response of structures by the response spectrum method

International Nuclear Information System (INIS)

Hadjian, A.H.

1981-01-01

The problems of the acceleration profile at the lower elevations of cantilever structures and the response of relatively rigid structures are explored. It is shown that the use of the conventional methods for the above problems provide very approximate results. An alternate combination of the modal responses is proposed that not only resolves the above problems but also provides better estimates of response for the complete range of structure frequencies. The procedure treats the relative and rigid body responses separately and then appropriately combines the two results. For the rigid range of frequencies (fundamental frequencies greater than about 2 Hz), the proposed procedure does not encounter any numerical difficulties because of the additive nature of the component responses; however, the application of the proposed procedure for very flexible structures causes accuracy problems since the rigid body effects tend to be subtractive from the flexural response of about equal magnitude. For this latter class of problems, the conventional approach of modal combination provides adequate results and avoids the above mentioned numerical difficulties. (orig.)

Responsibility without Guilt: A Youngian Approach to Responsibility for Global Injustice

OpenAIRE

McKeown, M. C.

2015-01-01

What responsibilities do individuals have in relation to global injustice? Iris Young argues that all agents “connected” to global structural injustice bear political responsibility, rather than moral responsibility; the difference being that political responsibility is non-blameworthy, shared and forward-looking, whereas moral responsibility entails blameworthiness, isolates particular agents for censure and is backward-looking. Thus, individuals are not guilty of wrongdoing but they bear re...

Response

Science.gov (United States)

Higgins, Chris

2012-01-01

This article presents the author's response to the reviews of his book, "The Good Life of Teaching: An Ethics of Professional Practice." He begins by highlighting some of the main concerns of his book. He then offers a brief response, doing his best to address the main criticisms of his argument and noting where the four reviewers (Charlene…

Playful Hyper Responsibility: Toward a Dislocation of Parents' Responsibility?

Science.gov (United States)

Knudsen, Hanne; Andersen, Niels Åkerstrøm

2014-01-01

Over the past 10-15?years, state-funded schools have begun to require parents to assume an undefined and infinite personal responsibility. In this article, we investigate how schools organize responsibility games to respond to this challenge and how these games affect the concept of responsibility. We point to a dislocation in the way parents are…

A randomised trial and economic evaluation of the effect of response mode on response rate, response bias, and item non-response in a survey of doctors

Directory of Open Access Journals (Sweden)

Witt Julia

2011-09-01

Full Text Available Abstract Background Surveys of doctors are an important data collection method in health services research. Ways to improve response rates, minimise survey response bias and item non-response, within a given budget, have not previously been addressed in the same study. The aim of this paper is to compare the effects and costs of three different modes of survey administration in a national survey of doctors. Methods A stratified random sample of 4.9% (2,702/54,160 of doctors undertaking clinical practice was drawn from a national directory of all doctors in Australia. Stratification was by four doctor types: general practitioners, specialists, specialists-in-training, and hospital non-specialists, and by six rural/remote categories. A three-arm parallel trial design with equal randomisation across arms was used. Doctors were randomly allocated to: online questionnaire (902; simultaneous mixed mode (a paper questionnaire and login details sent together (900; or, sequential mixed mode (online followed by a paper questionnaire with the reminder (900. Analysis was by intention to treat, as within each primary mode, doctors could choose either paper or online. Primary outcome measures were response rate, survey response bias, item non-response, and cost. Results The online mode had a response rate 12.95%, followed by the simultaneous mixed mode with 19.7%, and the sequential mixed mode with 20.7%. After adjusting for observed differences between the groups, the online mode had a 7 percentage point lower response rate compared to the simultaneous mixed mode, and a 7.7 percentage point lower response rate compared to sequential mixed mode. The difference in response rate between the sequential and simultaneous modes was not statistically significant. Both mixed modes showed evidence of response bias, whilst the characteristics of online respondents were similar to the population. However, the online mode had a higher rate of item non-response compared

10 CFR 851.20 - Management responsibilities and worker rights and responsibilities.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Management responsibilities and worker rights and... Program Requirements § 851.20 Management responsibilities and worker rights and responsibilities. (a... workers of their rights and responsibility by appropriate means, including posting the DOE-designated...

Bleaching response of coral species in the context of assemblage response

Science.gov (United States)

Swain, Timothy D.; DuBois, Emily; Goldberg, Scott J.; Backman, Vadim; Marcelino, Luisa A.

2017-06-01

Caribbean coral reefs are declining due to a mosaic of local and global stresses, including climate change-induced thermal stress. Species and assemblage responses differ due to factors that are not easily identifiable or quantifiable. We calculated a novel species-specific metric of coral bleaching response, taxon- α and - β, which relates the response of a species to that of its assemblages for 16 species over 18 assemblages. By contextualizing species responses within the response of their assemblages, the effects of environmental factors are removed and intrinsic differences among taxa are revealed. Most corals experience either a saturation response, overly sensitive to weak stress ( α > 0) but under-responsive compared to assemblage bleaching ( β bleaching ( β > 1). This metric may help reveal key factors of bleaching susceptibility and identify species as targets for conservation.

Biological response modifiers

Energy Technology Data Exchange (ETDEWEB)

Weller, R.E.

1991-10-01

Much of what used to be called immunotherapy is now included in the term biological response modifiers. Biological response modifiers (BRMs) are defined as those agents or approaches that modify the relationship between the tumor and host by modifying the host's biological response to tumor cells with resultant therapeutic effects.'' Most of the early work with BRMs centered around observations of spontaneous tumor regression and the association of tumor regression with concurrent bacterial infections. The BRM can modify the host response in the following ways: Increase the host's antitumor responses through augmentation and/or restoration of effector mechanisms or mediators of the host's defense or decrease the deleterious component by the host's reaction; Increase the host's defenses by the administration of natural biologics (or the synthetic derivatives thereof) as effectors or mediators of an antitumor response; Augment the host's response to modified tumor cells or vaccines, which might stimulate a greater response by the host or increase tumor-cell sensitivity to an existing response; Decrease the transformation and/or increase differentiation (maturation) of tumor cells; or Increase the ability of the host to tolerate damage by cytotoxic modalities of cancer treatment.

Towards the comparative ecotoxicology of bees: the response-response relationship

Directory of Open Access Journals (Sweden)

Cresswell, James E.

2012-10-01

Full Text Available Background: When an ecological system is exposed to an anthropogenic toxin, each species has an idiosyncratic sensitivity, but it is reasonable to expect some generality in response, especially among related species such as bees. If two species are similarly sensitive to a toxin their dose-response relationships will be similar. We propose a method to facilitate comparison between dose-response relationships, namely the response-response relationship, which can be applied to any biomarkers whose responses to the same pollutant are measured across a similar range of doses. We apply the method to bumble bees (Bombus terrestris and honey bees (Apis mellifera exposed to a dietary pesticide, imidacloprid, and we investigate both lethal and sublethal biomarkers.Results: We found cross-species similarity in dose-dependent responses, but only in certain sublethal biomarkers. In honey bees, sublethal biomarkers were more sensitive than mortality. In bumble bees, fecundity was the most sensitive biomarker.Conclusion: Our results provisionally suggest the existence of cross-species generalities. The greater sensitivity of sublethal biomarkers than mortality suggests that testing protocols which are overly focussed on mortality may underestimate the ecological impacts of toxic pollutants.

The business value of demand response for balance responsible parties

OpenAIRE

Jonsson, Mattias

2014-01-01

By using IT-solutions, the flexibility on the demand side in the electrical systems could be increased. This is called demand response and is part of the larger concept called smart grids. Previous work in this area has concerned the utilization of demand response by grid owners. In this thesis the focus will instead be shifted towards the electrical companies that have balance responsibility, and how they could use demand response in order to make profits. By investigating electrical applian...

Drivers of Organizational Responsiveness: Experiences of a Military Crisis Response Organization

Directory of Open Access Journals (Sweden)

Erik De Waard

2013-08-01

Full Text Available The topic of organizational responsiveness – where organizations need to flexibly react to strategic and operational demands simultaneously – has been under-explored in strategic management research. Our study was initiated to shed more light on this topic, primarily by studying an organization specifically designed to handle crises. By definition, crisis response organizations have to be prepared to react to unpredictable events. Moreover, the volatility of the crisis situation itself requires a high degree of flexibility to get or keep the situation under control. The study hypothesizes modular organizing and organizational sensing to be key drivers of organizational responsiveness. Empirically, we examine the effect these two variables have on the responsiveness of the Netherlands armed forces for crisis response deployment. Findings indicate that modular organizing and organizational sensing are drivers of responsiveness. In addition, our study uncovered the importance of an organization’s level of system decomposition to responsiveness. A high degree of system granularity can lead to a predominantly inward focus whereas organizational responsiveness calls for a strong external orientation.

Can responses to basic non-numerical visual features explain neural numerosity responses?

Science.gov (United States)

Harvey, Ben M; Dumoulin, Serge O

2017-04-01

Humans and many animals can distinguish between stimuli that differ in numerosity, the number of objects in a set. Human and macaque parietal lobes contain neurons that respond to changes in stimulus numerosity. However, basic non-numerical visual features can affect neural responses to and perception of numerosity, and visual features often co-vary with numerosity. Therefore, it is debated whether numerosity or co-varying low-level visual features underlie neural and behavioral responses to numerosity. To test the hypothesis that non-numerical visual features underlie neural numerosity responses in a human parietal numerosity map, we analyze responses to a group of numerosity stimulus configurations that have the same numerosity progression but vary considerably in their non-numerical visual features. Using ultra-high-field (7T) fMRI, we measure responses to these stimulus configurations in an area of posterior parietal cortex whose responses are believed to reflect numerosity-selective activity. We describe an fMRI analysis method to distinguish between alternative models of neural response functions, following a population receptive field (pRF) modeling approach. For each stimulus configuration, we first quantify the relationships between numerosity and several non-numerical visual features that have been proposed to underlie performance in numerosity discrimination tasks. We then determine how well responses to these non-numerical visual features predict the observed fMRI responses, and compare this to the predictions of responses to numerosity. We demonstrate that a numerosity response model predicts observed responses more accurately than models of responses to simple non-numerical visual features. As such, neural responses in cognitive processing need not reflect simpler properties of early sensory inputs. Copyright © 2017 Elsevier Inc. All rights reserved.

Responsive self-preservation: Towards an anthropological concept of responsiveness

Directory of Open Access Journals (Sweden)

Kasper Lysemose

2013-12-01

Full Text Available The aim of this paper is to catch up with a conjecture designated by the term ‘responsive self-preservation’. This term appears neither strikingly beautiful nor intuitively understandable. Obviously it is a convoluted terminus technicus in need of conceptual clarification. The reasons for introducing it should therefore be good. That this is the case cannot be guaranteed from the outset. What can be offered here is a substitution of good reasons with high ambitions: the concept of ‘responsive self-preservation’ is designed to illuminate the conditio humana. In all brevity the claim is that human beings are responsive beings. This means that they do not just exist. In order to do so, they must respond to their existence. On the one hand the inner drive and utmost aspiration in human responsiveness therefore lies in self-preservation. On the other hand self-preservation is thoroughly transformed when embedded into human responsiveness. The article will thus use the concept of responsiveness and the concept of self-preservation to mutually clarify each other – in order to open the possibilities and avoid the pitfalls in each of them. In doing so, it aspires to intervene in contemporary philosophical anthropology.

Computer incident response and forensics team management conducting a successful incident response

CERN Document Server

Johnson, Leighton

2013-01-01

Computer Incident Response and Forensics Team Management provides security professionals with a complete handbook of computer incident response from the perspective of forensics team management. This unique approach teaches readers the concepts and principles they need to conduct a successful incident response investigation, ensuring that proven policies and procedures are established and followed by all team members. Leighton R. Johnson III describes the processes within an incident response event and shows the crucial importance of skillful forensics team management, including when and where the transition to forensics investigation should occur during an incident response event. The book also provides discussions of key incident response components. Provides readers with a complete handbook on computer incident response from the perspective of forensics team management Identify the key steps to completing a successful computer incident response investigation Defines the qualities necessary to become a succ...

Responsibility and Capacities

DEFF Research Database (Denmark)

Ryberg, Jesper

2014-01-01

That responsible moral agency presupposes certain mental capacities, constitutes a widely accepted view among theorists. Moreover, it is often assumed that degrees in the development of the relevant capacities co-vary with degrees of responsibility. In this article it is argued that, the move from...... the view that responsibility requires certain mental capacities to the position that degrees of responsibility co-vary with degrees of the development of the mental capacities, is premature....

National Response Team

Science.gov (United States)

Response planning and coordination (not direct response itself) is accomplished at the federal level through the U.S. National Response Team (NRT), an interagency group co-chaired by EPA and U.S. Coast Guard. NRT distributes information, plans, and trains.

A Bivariate Generalized Linear Item Response Theory Modeling Framework to the Analysis of Responses and Response Times.

Science.gov (United States)

Molenaar, Dylan; Tuerlinckx, Francis; van der Maas, Han L J

2015-01-01

A generalized linear modeling framework to the analysis of responses and response times is outlined. In this framework, referred to as bivariate generalized linear item response theory (B-GLIRT), separate generalized linear measurement models are specified for the responses and the response times that are subsequently linked by cross-relations. The cross-relations can take various forms. Here, we focus on cross-relations with a linear or interaction term for ability tests, and cross-relations with a curvilinear term for personality tests. In addition, we discuss how popular existing models from the psychometric literature are special cases in the B-GLIRT framework depending on restrictions in the cross-relation. This allows us to compare existing models conceptually and empirically. We discuss various extensions of the traditional models motivated by practical problems. We also illustrate the applicability of our approach using various real data examples, including data on personality and cognitive ability.

Spatiotemporal Dynamics of Fire in Whitebark Pine Stands on two Mountains in the Lolo National Forest, Montana, USA.

Science.gov (United States)

Larson, E. R.; Grissino-Mayer, H. D.

2004-12-01

Whitebark pine (Pinus albicaulis) is a long-lived tree species that exists throughout high elevation and treeline forest communities of western North America. It is the foundation of a diminishing ecosystem that supports Clark's nutcrackers (Nucifraga columbiana), red squirrels (Tamiasciurus hudsonicus), grizzly bears (Ursus arctos), and black bears (U. americana). Several factors are directly linked to the decline of the whitebark pine ecosystem: mortality from recent and widespread mountain pine beetle (Dendroctonus ponderosae) outbreaks, infestation by the invasive white pine blister rust (Cronartium ribicola, an exotic fungal canker that weakens and eventually kills white pines), and fire suppression that may have altered the historic fire regime and enabled fire-intolerant tree species to encroach upon whitebark pine stands. The synergistic effects of these factors have led to a dramatic decline in whitebark pine communities throughout its native range, and in response land managers and conservationists have called for research to better understand the ecological dynamics of this little studied ecosystem. My research uses dendrochronology to investigate the fire history of whitebark pine stands on three mountains in the Lolo National Forest, Montana, via fire-scar and age structure analyses. I present here the results from the fire-scar analyses from Morrell Mountain where I obtained 40 cross sections from dead and down whitebark pines. Individual tree mean fire return intervals (MFRI) range from 33 to 119 years, with a stand MFRI of 49 years that includes fire scars dating to the 16th century. Fire events scarred multiple trees in AD 1754, 1796, and 1843, indicating a mixed-severity fire regime. The majority of the samples recorded a frost event in AD 1601, perhaps evidence of the AD 1600 eruption of Mt. Huaynapatina in the Peruvian Andes. My research not only provides an historical framework for land managers, but also provides an opportunity to examine long

Competing responsibly

NARCIS (Netherlands)

Jeurissen, R.J.M.; Ven, van de B.W.

2005-01-01

In this paper we examine the effects of different competitive conditions on the determination and evaluation of strategies of corporate social responsibility (CSR). Although the mainstream of current thinking in business ethics recognizes that a firm should invest in social responsibility, the

Biological Responses to Materials

Science.gov (United States)

Anderson, James M.

2001-08-01

All materials intended for application in humans as biomaterials, medical devices, or prostheses undergo tissue responses when implanted into living tissue. This review first describes fundamental aspects of tissue responses to materials, which are commonly described as the tissue response continuum. These actions involve fundamental aspects of tissue responses including injury, inflammatory and wound healing responses, foreign body reactions, and fibrous encapsulation of the biomaterial, medical device, or prosthesis. The second part of this review describes the in vivo evaluation of tissue responses to biomaterials, medical devices, and prostheses to determine intended performance characteristics and safety or biocompatibility considerations. While fundamental aspects of tissue responses to materials are important from research and development perspectives, the in vivo evaluation of tissue responses to these materials is important for performance, safety, and regulatory reasons.

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

International Nuclear Information System (INIS)

Calabrese, Edward J.; Bachmann, Kenneth A.; Bailer, A. John; Bolger, P. Michael; Borak, Jonathan; Cai, Lu; Cedergreen, Nina; Cherian, M. George; Chiueh, Chuang C.; Clarkson, Thomas W.; Cook, Ralph R.; Diamond, David M.; Doolittle, David J.; Dorato, Michael A.; Duke, Stephen O.; Feinendegen, Ludwig; Gardner, Donald E.; Hart, Ronald W.; Hastings, Kenneth L.; Hayes, A. Wallace; Hoffmann, George R.; Ives, John A.; Jaworowski, Zbigniew; Johnson, Thomas E.; Jonas, Wayne B.; Kaminski, Norbert E.; Keller, John G.; Klaunig, James E.; Knudsen, Thomas B.; Kozumbo, Walter J.; Lettieri, Teresa; Liu, Shu-Zheng; Maisseu, Andre; Maynard, Kenneth I.; Masoro, Edward J.; McClellan, Roger O.; Mehendale, Harihara M.; Mothersill, Carmel; Newlin, David B.; Nigg, Herbert N.; Oehme, Frederick W.; Phalen, Robert F.; Philbert, Martin A.; Rattan, Suresh I.S.; Riviere, Jim E.; Rodricks, Joseph; Sapolsky, Robert M.; Scott, Bobby R.; Seymour, Colin; Sinclair, David A.; Smith-Sonneborn, Joan; Snow, Elizabeth T.; Spear, Linda; Stevenson, Donald E.; Thomas, Yolene; Tubiana, Maurice; Williams, Gary M.; Mattson, Mark P.

2007-01-01

Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines

Rapid response systems.

Science.gov (United States)

Lyons, Patrick G; Edelson, Dana P; Churpek, Matthew M

2018-07-01

Rapid response systems are commonly employed by hospitals to identify and respond to deteriorating patients outside of the intensive care unit. Controversy exists about the benefits of rapid response systems. We aimed to review the current state of the rapid response literature, including evolving aspects of afferent (risk detection) and efferent (intervention) arms, outcome measurement, process improvement, and implementation. Articles written in English and published in PubMed. Rapid response systems are heterogeneous, with important differences among afferent and efferent arms. Clinically meaningful outcomes may include unexpected mortality, in-hospital cardiac arrest, length of stay, cost, and processes of care at end of life. Both positive and negative interventional studies have been published, although the two largest randomized trials involving rapid response systems - the Medical Early Response and Intervention Trial (MERIT) and the Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients (EPOCH) trial - did not find a mortality benefit with these systems, albeit with important limitations. Advances in monitoring technologies, risk assessment strategies, and behavioral ergonomics may offer opportunities for improvement. Rapid responses may improve some meaningful outcomes, although these findings remain controversial. These systems may also improve care for patients at the end of life. Rapid response systems are expected to continue evolving with novel developments in monitoring technologies, risk prediction informatics, and work in human factors. Copyright © 2018 Elsevier B.V. All rights reserved.

Response Strategies and Response Styles in Cross-Cultural Surveys

NARCIS (Netherlands)

Morren, M.H.; Gelissen, J.P.T.M.; Vermunt, J.K.

2012-01-01

This article addresses the following research questions: Do respondents participating in cross-cultural surveys differ in their response style when responding to attitude statements? If so, are characteristics of the response process associated with their ethnicity and generation of immigration? To

Host response to biomaterials the impact of host response on biomaterial selection

CERN Document Server

Badylak, Stephen F

2015-01-01

Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fiel

Gaming industry employees' responses to responsible gambling training: a public health imperative.

Science.gov (United States)

LaPlante, Debi A; Gray, Heather M; LaBrie, Richard A; Kleschinsky, John H; Shaffer, Howard J

2012-06-01

Gaming industry employees work in settings that create personal health risks. They also have direct contact with customers who might engage in multiple risky activities (e.g., drinking, smoking, and gambling) and might need to facilitate help-seeking by patrons or co-workers who experience problems. Consequently, the empirical examination of the processes and procedures designed to prepare employees for such complex situations is a public health imperative. In the current study we describe an evaluation of the Casino, Inc. Play Responsibly responsible gaming program. We surveyed 217 employees prior to and 1 month after (n = 116) they completed a multimedia driven responsible gambling training program. We observed that employees improved their knowledge of responsible gambling concepts from baseline to follow-up. The Play Responsibly program was more successful in providing new knowledge than it was in correcting mistaken beliefs that existed prior to training. We conclude, generally, that Play Responsibly is associated with increases in employees' responsible gambling knowledge.

Risk and response

Energy Technology Data Exchange (ETDEWEB)

Warner, F W

1980-12-01

A discussion of nuclear power and public acceptability can quite properly begin with a general consideration of the nature of response to risk. Response follows perception and builds up from individual through group response to the judgement of society expressed in governmental decisions on what is acceptable. The subject is analysed in some detail, with examples.

Risk and response

Energy Technology Data Exchange (ETDEWEB)

Warner, F [Cremer and Warner (UK)

1981-01-01

A discussion of nuclear power and public acceptability can quite properly begin with a general consideration of the nature of response to risk. Response follows perception, and builds up from the individual through group response to the judgement of society expressed in governmental decisions on what is acceptable. Various types of risk, and public reaction, are discussed.

Societal response to nanotechnology: converging technologies–converging societal response research?

International Nuclear Information System (INIS)

Ronteltap, Amber; Fischer, Arnout R. H.; Tobi, Hilde

2011-01-01

Nanotechnology is an emerging technology particularly vulnerable to societal unrest, which may hinder its further development. With the increasing convergence of several technological domains in the field of nanotechnology, so too could convergence of social science methods help to anticipate societal response. This paper systematically reviews the current state of convergence in societal response research by first sketching the predominant approaches to previous new technologies, followed by an analysis of current research into societal response to nanotechnology. A set of 107 papers on previous new technologies shows that rational actor models have played an important role in the study of societal response to technology, in particular in the field of information technology and the geographic region of Asia. Biotechnology and nuclear power have, in contrast, more often been investigated through risk perception and other affective determinants, particularly in Europe and the USA. A set of 42 papers on societal response to nanotechnology shows similarities to research in biotechnology, as it also builds on affective variables such as risk perception. Although there is a tendency to extend the rational models with affective variables, convergence in social science approaches to response to new technologies still has a long way to go. The challenge for researchers of societal response to technologies is to converge to some shared principles by taking up the best parts from the rational actor models dominant in information technology, whilst integrating non-rational constructs from biotechnology research. The introduction of nanotechnology gives a unique opportunity to do so.

Neutron response study

International Nuclear Information System (INIS)

Endres, G.W.R.; Fix, J.J.; Thorson, M.R.; Nichols, L.L.

1981-01-01

Neutron response of the albedo type dosimeter is strongly dependent on the energy of the incident neutrons as well as the moderating material on the backside of the dosimeter. This study characterizes the response of the Hanford dosimeter for a variety of neutron energies for both a water and Rando phantom (a simulated human body consisting of an actual human skeleton with plastic for body muscles and certain organs). The Hanford dosimeter response to neutrons of different energies is typical of albedo type dosimeters. An approximate two orders of magnitude difference in response is observed between neutron energies of 100 keV and 10 MeV. Methods were described to compensate for the difference in dosimeter response between a laboratory neutron spectrum and the different spectra encountered at various facilities in the field. Generally, substantial field support is necessary for accurate neutron dosimetry

Response to intravenous fentanyl infusion predicts subsequent response to transdermal fentanyl.

Science.gov (United States)

Hayashi, Norihito; Kanai, Akifumi; Suzuki, Asaha; Nagahara, Yuki; Okamoto, Hirotsugu

2016-04-01

Prediction of the response to transdermal fentanyl (FENtd) before its use for chronic pain is desirable. We tested the hypothesis that the response to intravenous fentanyl infusion (FENiv) can predict the response to FENtd, including the analgesic and adverse effects. The study subjects were 70 consecutive patients with chronic pain. The response to fentanyl at 0.1 mg diluted in 50 ml of physiological saline and infused over 30 min was tested. This was followed by treatment with FENtd (Durotep MT patch 2.1 mg) at a dose of 12.5 µg/h for 2 weeks. Pain intensity before and after FENiv and 2 weeks after FENtd, and the response to treatment, were assessed by the numerical rating scale (NRS), clinical global impression-improvement scale (CGI-I), satisfaction scale (SS), and adverse effects. The NRS score decreased significantly from 7 (4-9) [median (range)] at baseline to 3 (0-8) after FENiv (p 0.04, each). The analgesic and side effects after intravenous fentanyl infusion can be used to predict the response to short-term transdermal treatment with fentanyl.

Responsive web design workflow

OpenAIRE

LAAK, TIMO

2013-01-01

Responsive Web Design Workflow is a literature review about Responsive Web Design, a web standards based modern web design paradigm. The goals of this research were to define what responsive web design is, determine its importance in building modern websites and describe a workflow for responsive web design projects. Responsive web design is a paradigm to create adaptive websites, which respond to the properties of the media that is used to render them. The three key elements of responsi...

The Value of Response Times in Item Response Modeling

Science.gov (United States)

Molenaar, Dylan

2015-01-01

A new and very interesting approach to the analysis of responses and response times is proposed by Goldhammer (this issue). In his approach, differences in the speed-ability compromise within respondents are considered to confound the differences in ability between respondents. These confounding effects of speed on the inferences about ability can…

Radiological evaluation of tumor response in oncological studies (tumor response evaluation)

International Nuclear Information System (INIS)

Gebauer, B.; Riess, H.

2011-01-01

Purpose: Radiological-morphological response evaluation plays a major role in oncological therapy and studies for approval. Specific criteria have been developed for some tumor entities and chemotherapeutics. Application, limitations and definitions of the most frequently used criteria for tumor response evaluation will be presented. Materials and Methods: Review based on a selective literature research. Results: In clinical oncological therapy studies, WHO and RECIST are the most frequently used criteria to evaluate morphological therapy response. RECIST criteria have been modified recently, especially with respect to the evaluation of lymph nodes, and were published as RECIST 1.1 in 2009. All criteria were originally developed and defined to review clinical multicenter trials for approval. Using these criteria in a clinical situation, certain limitations have to be considered. To evaluate response, a baseline scan before therapy start is mandatory. Special tumor response criteria have been defined for some certain tumor entities. Oncologists and radiologists should define in advance which criteria are used before starting therapy. Conclusion: The use of defined criteria is very important in oncology response evaluation. In-depth knowledge of the criteria and their limits is required for correct usage. (orig.)

Electrodermal Response in Gaming

Directory of Open Access Journals (Sweden)

J. Christopher Westland

2011-01-01

Full Text Available Steady improvements in technologies that measure human emotional response offer new possibilities for making computer games more immersive. This paper reviews the history of designs a particular branch of affective technologies that acquire electrodermal response readings from human subjects. Electrodermal response meters have gone through continual improvements to better measure these nervous responses, but still fall short of the capabilities of today's technology. Electrodermal response traditionally have been labor intensive. Protocols and transcription of subject responses were recorded on separate documents, forcing constant shifts of attention between scripts, electrodermal measuring devices and of observations and subject responses. These problems can be resolved by collecting more information and integrating it in a computer interface that is, by adding relevant sensors in addition to the basic electrodermal resistance reading to untangle (1 body resistance; (2 skin resistance; (3 grip movements; other (4 factors affecting the neural processing for regulation of the body. A device that solves these problems is presented and discussed. It is argued that the electrodermal response datastreams can be enriched through the use of added sensors and a digital acquisition and processing of information, which should further experimentation and use of the technology.

Social Responsibility Instruments

Directory of Open Access Journals (Sweden)

Katarzyna Mizera

2008-09-01

Full Text Available Responsible business notion is more and more present in Polish economy, however the results of the research carried out in Polish business still shows a low level of CRS idea knowledge, especially in small and medium companies. Although responsible business notion is generally known, its details, ways of preparing strategy, instruments and what is more its benefits are still narrowly spread. Many business people face the lack of knowledge and information, which on one hand make it easier to spread and deepen wrong stereotypes connected with this notion and on the other hand make business people unwilling to implement CRS in their companies. The subjects of this article are examples of instruments which are responsible for realization of social responsibility strategy.

When the ball is in the female's court: How the scramble-competition mating system of the North American red squirrel has shaped male physiology and testosterone dynamics.

Science.gov (United States)

Boonstra, Rudy; Dušek, Adam; Lane, Jeffrey E; Boutin, Stan

2017-10-01

Male reproductive success in most mammals is determined by their success in direct inter-male competition through aggression and conflict, resulting in female-defense mating systems being predominant. This is linked to male testosterone levels and its dynamics. However, in certain environments, a scramble-competition mating system has evolved, where female reproductive behavior takes precedence and male testosterone dynamics are unlikely to be related to inter-male competition. We studied the North American red squirrel (Tamiasciurus hudsonicus), a species with a well-established scramble-competition system. Using an ACTH hormonal challenge protocol as a proxy for competitive interactions, we compared the testosterone dynamics in breeding males in late winter with that in nonbreeding males in late spring in the Yukon. To gain an integrated picture of their physiological state, we also assessed changes in their stress response, body mass, energy mobilization, and indices of immune function. Testosterone levels at the base bleed were high in breeding males (2.72ng/mL) and virtually absent in non-breeding males (0.04ng/mL). Breeding males were in better condition (heavier body mass, higher hematocrit, and higher erythrocytes), had higher indices of immune function (neutrophil:lymphocyte ratio), but a similar ability to mobilize energy (glucose) compared with non-breeding males. Though total cortisol was higher in non-breeding males, free cortisol was twice as high in breeding males as their corticosteroid binding globulin levels were half as high. In response to the ACTH challenge, testosterone levels in breeding males declined 49% over the first hour and increased 36% over the next hour; in non-breeding males levels showed no change. Free cortisol increased only modestly (26% in breeding males; 23% in non-breeding males). Glucose levels changed similarly in breeding and nonbreeding males, declining for the first 30min and then increasing for the next 60min. Thus

Population responses in V1 encode different figures by response amplitude.

Science.gov (United States)

Gilad, Ariel; Slovin, Hamutal

2015-04-22

The visual system simultaneously segregates between several objects presented in a visual scene. The neural code for encoding different objects or figures is not well understood. To study this question, we trained two monkeys to discriminate whether two elongated bars are either separate, thus generating two different figures, or connected, thus generating a single figure. Using voltage-sensitive dyes, we imaged at high spatial and temporal resolution V1 population responses evoked by the two bars, while keeping their local attributes similar among the two conditions. In the separate condition, unlike the connected condition, the population response to one bar is enhanced, whereas the response to the other is simultaneously suppressed. The response to the background remained unchanged between the two conditions. This divergent pattern developed ∼200 ms poststimulus onset and could discriminate well between the separate and connected single trials. The stimulus separation saliency and behavioral report were highly correlated with the differential response to the bars. In addition, the proximity and/or the specific location of the connectors seemed to have only a weak effect on this late activity pattern, further supporting the involvement of top-down influences. Additional neural codes were less informative about the separate and connected conditions, with much less consistency and discriminability compared with a response amplitude code. We suggest that V1 is involved in the encoding of each figure by different neuronal response amplitude, which can mediate their segregation and perception. Copyright © 2015 the authors 0270-6474/15/356335-15$15.00/0.

Frequency Response Analysis Tool

Energy Technology Data Exchange (ETDEWEB)

Etingov, Pavel V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kosterev, Dmitry [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dai, T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2014-12-01

Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

Marine oil spill response organizations

International Nuclear Information System (INIS)

Hendry, C.

1997-01-01

The obligations under the law relative to the prevention of marine oil spills and the type of emergency plans needed to mitigate any adverse effects caused by a marine oil spill were discussed. The organizational structure, spill response resources and operational management capabilities of Canada's newly created Response Organizations (ROs) were described. The overall range of oil spill response services that the RO provides to the domestic oil handling, oil transportation and the international shipping industries were reviewed. Amendments to the Canada Shipping Act which require that certain ships and oil handling facilities take oil spill preparedness and response measures, including having an arrangement with an RO certified by the Canadian Coast Guard, were outlined. Canadians now benefit from five ROs established to provide coast-to-coast oil spill response coverage. These include the Western Canada Marine Response Corporation, the Canadian Marine Response Management Corporation, the Great Lakes Response Corporation, the Eastern Canada Response Corporation and the Atlantic Emergency Response Team Ltd. ROs have the expertise necessary to organize and manage marine oil spill response services. They can provide equipment, personnel and operational management for the containment, recovery and cleanup of oil spilled on water

Procedure for determining the SSE response from the OBE response

International Nuclear Information System (INIS)

Curreri, J.

1985-01-01

Regulatory Guide 1.61 specifies the damping that should be used for all modes that are considered in an elastic spectral or time history dynamic seismic analysis of Seismic Category I components. Table 1 of R.G 1.61 specifies damping values for dynamic analysis for two different earthquakes, the Safe Shutdown Earthquake and the Operating Basis Earthquake. The guide specifies that ''...if the maximum stresses due to static, seismic and other dynamic loading are significantly lower than the yield stresses and 1/2 yield stress for SSE and 1/2 SSE respectively, in any structure a component damping values lower than those specified in Table 1 ....should be used .... to avoid underestimating the amplitude of vibration of dynamic stress.'' The guide requires that the appropiate damping values be used which reflect the state of stress that will be experienced by the equipment. In applying these values to the response of equipment, to an OBE and to an SSE, the selected damping should result in a dynamic response for the SSE that is greater than the response due to the OBE, all other factors being equal. The purpose of the statement in the guide is to note that at higher stress levels, the higher damping values could be used, but at lower stress levels, the lower values of damping should be used. Current procedures that are used in implementing R.G. 1.61 frequently result in an OBE response that is greater than the SSE response. This is because the higher damping under the SSE is used at all stress levels, low as well as high. This is obviously not the intent of the Regulatory Guide. A procedure has been developed which derives an expression relating the SSE response to the OBE response. Two factors are involved in the equation. The first involves the damping ratios for the SSE and OBE events and the second is the ratio between the levels of the OBE and SSE

Geospatial Information Response Team

Science.gov (United States)

Witt, Emitt C.

2010-01-01

Extreme emergency events of national significance that include manmade and natural disasters seem to have become more frequent during the past two decades. The Nation is becoming more resilient to these emergencies through better preparedness, reduced duplication, and establishing better communications so every response and recovery effort saves lives and mitigates the long-term social and economic impacts on the Nation. The National Response Framework (NRF) (http://www.fema.gov/NRF) was developed to provide the guiding principles that enable all response partners to prepare for and provide a unified national response to disasters and emergencies. The NRF provides five key principles for better preparation, coordination, and response: 1) engaged partnerships, 2) a tiered response, 3) scalable, flexible, and adaptable operations, 4) unity of effort, and 5) readiness to act. The NRF also describes how communities, tribes, States, Federal Government, privatesector, and non-governmental partners apply these principles for a coordinated, effective national response. The U.S. Geological Survey (USGS) has adopted the NRF doctrine by establishing several earth-sciences, discipline-level teams to ensure that USGS science, data, and individual expertise are readily available during emergencies. The Geospatial Information Response Team (GIRT) is one of these teams. The USGS established the GIRT to facilitate the effective collection, storage, and dissemination of geospatial data information and products during an emergency. The GIRT ensures that timely geospatial data are available for use by emergency responders, land and resource managers, and for scientific analysis. In an emergency and response capacity, the GIRT is responsible for establishing procedures for geospatial data acquisition, processing, and archiving; discovery, access, and delivery of data; anticipating geospatial needs; and providing coordinated products and services utilizing the USGS' exceptional pool of

Conflicts during response selection affect response programming: reactions toward the source of stimulation.

Science.gov (United States)

Buetti, Simona; Kerzel, Dirk

2009-06-01

In the Simon effect, participants make a left or right keypress in response to a nonspatial attribute (e.g., color) that is presented on the left or right. Reaction times (RTs) increase when the response activated by the irrelevant stimulus location and the response retrieved by instruction are in conflict. The authors measured RTs and movement parameters (MPs) of pointing responses in a typical Simon task. Their results show that the trajectories veer toward the imperative stimulus. This bias decreased as RTs increased. The authors suggest that the time course of trajectory deviations reflects the resolution of the response conflict over time. Further, time pressure did not affect the size of the Simon effect in MPs or its time course, but strongly reduced the Simon effect in RTs. In contrast, response selection before the onset of a go signal on the left or right did not affect the Simon effect in RTs, but reduced the Simon effect in MPs and reversed the time course. The authors speculate about independent Simon effects associated with response selection and programming. (c) 2009 APA, all rights reserved.

A Comparison of Response Rate, Response Time, and Costs of Mail and Electronic Surveys.

Science.gov (United States)

Shannon, David M.; Bradshaw, Carol C.

2002-01-01

Compared response rates, response time, and costs of mail and electronic surveys using a sample of 377 college faculty members. Mail surveys yielded a higher response rate and a lower rate of undeliverable surveys, but response time was longer and costs were higher than for electronic surveys. (SLD)

Oil spill response plan

International Nuclear Information System (INIS)

1999-08-01

The plan outlined in this document specifies the actions that the Canadian Wildlife Service Atlantic Region is mandated to take in the event of an oil spill, or on discovering oiled migratory birds in terrestrial, fresh water, marine and inter-tidal habitats. In addition to describing the role and responsibilities of the Canadian Wildlife Service, the document also describes response plans of other agencies for dealing with all wildlife species affected by oil spills. Reporting paths, the lead agency concept, shared responsibilities with other Canadian Wildlife Service regional offices, provincial agencies, Heritage Canada, non-government wildlife response agencies, oil spill response organizations, and international organizations are outlined. An overview of the reporting and communications process is also provided

Responsible tourism

Directory of Open Access Journals (Sweden)

Birkaš E.

2012-01-01

Full Text Available Realising tourism in the context of responsibility is a problem of historical-social and economic time-space continuum; the problem of possibility of temporal unification of these parts. The study aims to emphasize that the essence of problem can only be understood in the depth of a general problematic of tourism, as a question of temporalisation of historical-social space, which, however, leads to a grand question of today: does the human activity which creates temporalised spaces have its own gravitational direction? Ad deliberandum. The study proposes the viewpoint that the context of responsibility requires overcoming the dimension of interpretation where the subject is understood as an ultimate human-singularity and a perfect match of responsibility with a dominant and current form of temporalisation of time suggests a paradigm of participating consciousness, the consciousness of unity, which, in Berdyaev's words, is never logical, but existential. The study, on the basis of a meticulous studying of a new narrative of tourism, primarily due to volume restrictions does not go beyond presenting the key attributes of this ever-expanding understanding of tourism - with a demonstration of a concrete practice - but all this with an emphasis that qualification of the actors' activities is possible only along the lines of a previous consideration of comprehension of structure of space and time - along the revalorisation of a motivational horison (Anzenbacher, A 1987, 264.p. and also the very term of responsibility and freedom. Responsibility can only then become an orientation of tourist activities, if the primary focus is set on re-comprehension (revalorisation of civilisational legacies in a timeless perspective.

Stimuli-Responsive Polymeric Nanoparticles.

Science.gov (United States)

Liu, Xiaolin; Yang, Ying; Urban, Marek W

2017-07-01

There is increasing evidence that stimuli-responsive nanomaterials have become significantly critical components of modern materials design and technological developments. Recent advances in synthesis and fabrication of stimuli-responsive polymeric nanoparticles with built-in stimuli-responsive components (Part A) and surface modifications of functional nanoparticles that facilitate responsiveness (Part B) are outlined here. The synthesis and construction of stimuli-responsive spherical, core-shell, concentric, hollow, Janus, gibbous/inverse gibbous, and cocklebur morphologies are discussed in Part A, with the focus on shape, color, or size changes resulting from external stimuli. Although inorganic/metallic nanoparticles exhibit many useful properties, including thermal or electrical conductivity, catalytic activity, or magnetic properties, their assemblies and formation of higher order constructs are often enhanced by surface modifications. Section B focuses on selected surface reactions that lead to responsiveness achieved by decorating nanoparticles with stimuli-responsive polymers. Although grafting-to and grafting-from dominate these synthetic efforts, there are opportunities for developing novel synthetic approaches facilitating controllable recognition, signaling, or sequential responses. Many nanotechnologies utilize a combination of organic and inorganic phases to produce ceramic or metallic nanoparticles. One can envision the development of new properties by combining inorganic (metals, metal oxides) and organic (polymer) phases into one nanoparticle designated as "ceramers" (inorganics) and "metamers" (metallic). © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Socially Response-Able Mathematics Education: Implications of an Ethical Approach

Science.gov (United States)

Atweh, Bill; Brady, Kate

2009-01-01

This paper discusses an approach to mathematics education based on the concept of ethical responsibility. It argues that an ethical approach to mathematics teaching lays the theoretical foundations for social justice concerns in the discipline. The paper develops a particular understanding of ethical responsibility based on the writings of Emanuel…

Drones and Responsibility

DEFF Research Database (Denmark)

How does the use of military drones affect the legal, political, and moral responsibility of different actors involved in their deployment and design? This volume offers a fresh contribution to the ethics of drone warfare by providing, for the first time, a systematic interdisciplinary discussion...... of different responsibility issues raised by military drones. The book discusses four main sets of questions: First, from a legal point of view, we analyse the ways in which the use of drones makes the attribution of criminal responsibility to individuals for war crimes more complicated and what adjustments...... may be required in international criminal law and in military practices to avoid ’responsibility gaps’ in warfare. From a moral and political perspective, the volume looks at the conditions under which the use of military drones by states is impermissible, permissible, or even obligatory and what...

Emergency response strategies

International Nuclear Information System (INIS)

Carrilo, D.; Dias de la Cruz, F.

1984-01-01

In the present study is estimated, on the basis of a release category (PWR4) and several accident scenarios previously set up, the emergency response efficacy obtained in the application of different response strategies on each of the above mentioned scenarios. The studied strategies contemplate the following protective measures: evacuation, shelter and relocation. The radiological response has been obtained by means of CRAC2 (Calculation of Reactor Accident Consequences) code, and calculated in terms of absorbed dose equivalent (Whole body and thyroid), as well as early and latent biological effects. (author)

On being responsible

DEFF Research Database (Denmark)

Davies, Sarah Rachael; Glerup, Cecilie; Horst, Maja

2014-01-01

as to enable innovation. To call for responsibility has, indeed, become somewhat trite. In this essay we take not the normative demand for responsibility, but its operationalisation, as our analytical focus, arguing that it is important not to underestimate the term’s practical flexibility and discursive...... multiplicity. To illustrate this point we consider firstly the range of ways in which ‘responsibility’ is articulated within the literature on higher education and sociology of science; and, secondly, how notions of responsible development are understood, and acted upon, in two different US sites: an academic...

Excessive biologic response to IFNβ is associated with poor treatment response in patients with multiple sclerosis.

Directory of Open Access Journals (Sweden)

Richard A Rudick

Full Text Available BACKGROUND: Interferon-beta (IFNβ is used to inhibit disease activity in multiple sclerosis (MS, but its mechanisms of action are incompletely understood, individual treatment response varies, and biological markers predicting response to treatment have yet to be identified. METHODS: The relationship between the molecular response to IFNβ and treatment response was determined in 85 patients using a longitudinal design in which treatment effect was categorized by brain magnetic resonance imaging as good (n = 70 or poor response (n = 15. Molecular response was quantified using a customized cDNA macroarray assay for 166 IFN-regulated genes (IRGs. RESULTS: The molecular response to IFNβ differed significantly between patients in the pattern and number of regulated genes. The molecular response was strikingly stable for individuals for as long as 24 months, however, suggesting an individual 'IFN response fingerprint'. Unexpectedly, patients with poor response showed an exaggerated molecular response. IRG induction ratios demonstrated an exaggerated molecular response at both the first and 6-month IFNβ injections. CONCLUSION: MS patients exhibit individually unique but temporally stable biological responses to IFNβ. Poor treatment response is not explained by the duration of biological effects or the specific genes induced. Rather, individuals with poor treatment response have a generally exaggerated biological response to type 1 IFN injections. We hypothesize that the molecular response to type I IFN identifies a pathogenetically distinct subset of MS patients whose disease is driven in part by innate immunity. The findings suggest a strategy for biologically based, rational use of IFNβ for individual MS patients.

Enhancing response coordination through the assessment of response network structural dynamics.

Directory of Open Access Journals (Sweden)

Alireza Abbasi

Full Text Available Preparing for intensifying threats of emergencies in unexpected, dangerous, and serious natural or man-made events, and consequent management of the situation, is highly demanding in terms of coordinating the personnel and resources to support human lives and the environment. This necessitates prompt action to manage the uncertainties and risks imposed by such extreme events, which requires collaborative operation among different stakeholders (i.e., the personnel from both the state and local communities. This research aims to find a way to enhance the coordination of multi-organizational response operations. To do so, this manuscript investigates the role of participants in the formed coordination response network and also the emergence and temporal dynamics of the network. By analyzing an inter-personal response coordination operation to an extreme bushfire event, the networks' and participants' structural change is evaluated during the evolution of the operation network over four time durations. The results reveal that the coordination response network becomes more decentralized over time due to the high volume of communication required to exchange information. New emerging communication structures often do not fit the developed plans, which stress the need for coordination by feedback in addition to by plan. In addition, we find that the participant's brokering role in the response operation network identifies a formal and informal coordination role. This is useful for comparison of network structures to examine whether what really happens during response operations complies with the initial policy.

Discord of response

International Nuclear Information System (INIS)

Roga, W; Illuminati, F; Giampaolo, S M

2014-01-01

The presence of quantum correlations in a quantum state is related to the state's response to local unitary perturbations. Such a response is quantified by the distance between the unperturbed and perturbed states, minimized with respect to suitably identified sets of local unitary operations. In order to be a bona fide measure of quantum correlations, the distance function must be chosen among those that are contractive under completely positive and trace preserving (CPTP) maps. The most relevant instances of such physically well-behaved metrics include the trace, the Bures, and the Hellinger distance. To each of these metrics one can associate the corresponding discord of response, namely the trace, or Hellinger, or Bures minimum distance from the set of unitarily perturbed states. All these three discords of response satisfy the basic axioms for a proper measure of quantum correlations. In the present work we focus in particular on the Bures distance, which enjoys the unique property of being both Riemannian and contractive under CPTP maps, and admits important operational interpretations in terms of state distinguishability. We compute analytically the Bures discord of response for two-qubit states with maximally mixed marginals and we compare it with the corresponding Bures geometric discord, namely the geometric measure of quantum correlations defined as the Bures distance from the set of classical-quantum states. Finally, we investigate and identify the maximally quantum correlated two-qubit states according to the Bures discord of response. These states exhibit a remarkable nonlinear dependence on the global state purity. (paper)

Applying Item Response Theory Methods to Examine the Impact of Different Response Formats

Science.gov (United States)

Hohensinn, Christine; Kubinger, Klaus D.

2011-01-01

In aptitude and achievement tests, different response formats are usually used. A fundamental distinction must be made between the class of multiple-choice formats and the constructed response formats. Previous studies have examined the impact of different response formats applying traditional statistical approaches, but these influences can also…

Predicting the response of olfactory sensory neurons to odor mixtures from single odor response

Science.gov (United States)

Marasco, Addolorata; de Paris, Alessandro; Migliore, Michele

2016-04-01

The response of olfactory receptor neurons to odor mixtures is not well understood. Here, using experimental constraints, we investigate the mathematical structure of the odor response space and its consequences. The analysis suggests that the odor response space is 3-dimensional, and predicts that the dose-response curve of an odor receptor can be obtained, in most cases, from three primary components with specific properties. This opens the way to an objective procedure to obtain specific olfactory receptor responses by manipulating mixtures in a mathematically predictable manner. This result is general and applies, independently of the number of odor components, to any olfactory sensory neuron type with a response curve that can be represented as a sigmoidal function of the odor concentration.

Response Surface Methodology

NARCIS (Netherlands)

Kleijnen, Jack P.C.

2014-01-01

Abstract: This chapter first summarizes Response Surface Methodology (RSM), which started with Box and Wilson’s article in 1951 on RSM for real, non-simulated systems. RSM is a stepwise heuristic that uses first-order polynomials to approximate the response surface locally. An estimated polynomial

Item Response Data Analysis Using Stata Item Response Theory Package

Science.gov (United States)

Yang, Ji Seung; Zheng, Xiaying

2018-01-01

The purpose of this article is to introduce and review the capability and performance of the Stata item response theory (IRT) package that is available from Stata v.14, 2015. Using a simulated data set and a publicly available item response data set extracted from Programme of International Student Assessment, we review the IRT package from…

Understanding the Relation between Attitude Involvement and Response Latitude Using Item Response Theory

Science.gov (United States)

Lake, Christopher J.; Withrow, Scott; Zickar, Michael J.; Wood, Nicole L.; Dalal, Dev K.; Bochinski, Joseph

2013-01-01

Adapting the original latitude of acceptance concept to Likert-type surveys, response latitudes are defined as the range of graded response options a person is willing to endorse. Response latitudes were expected to relate to attitude involvement such that high involvement was linked to narrow latitudes (the result of selective, careful…

A semi-parametric within-subject mixture approach to the analyses of responses and response times.

Science.gov (United States)

Molenaar, Dylan; Bolsinova, Maria; Vermunt, Jeroen K

2018-05-01

In item response theory, modelling the item response times in addition to the item responses may improve the detection of possible between- and within-subject differences in the process that resulted in the responses. For instance, if respondents rely on rapid guessing on some items but not on all, the joint distribution of the responses and response times will be a multivariate within-subject mixture distribution. Suitable parametric methods to detect these within-subject differences have been proposed. In these approaches, a distribution needs to be assumed for the within-class response times. In this paper, it is demonstrated that these parametric within-subject approaches may produce false positives and biased parameter estimates if the assumption concerning the response time distribution is violated. A semi-parametric approach is proposed which resorts to categorized response times. This approach is shown to hardly produce false positives and parameter bias. In addition, the semi-parametric approach results in approximately the same power as the parametric approach. © 2017 The British Psychological Society.

Coupled multiple-response versus free-response conceptual assessment: An example from upper-division physics

Directory of Open Access Journals (Sweden)

Bethany R. Wilcox

2014-10-01

Full Text Available Free-response research-based assessments, like the Colorado Upper-division Electrostatics Diagnostic (CUE, provide rich, fine-grained information about students’ reasoning. However, because of the difficulties inherent in scoring these assessments, the majority of the large-scale conceptual assessments in physics are multiple choice. To increase the scalability and usability of the CUE, we set out to create a new version of the assessment that preserves the insights afforded by a free-response format while exploiting the logistical advantages of a multiple-choice assessment. We used our extensive database of responses to the free-response CUE to construct distractors for a new version where students can select multiple responses and receive partial credit based on the accuracy and consistency of their selections. Here, we describe the development of this modified CUE format, which we call coupled multiple response (CMR, and present data from direct comparisons of both versions. We find that the two formats have the same average score and perform similarly on multiple measures of validity and reliability, suggesting that the new version is a potentially viable alternative to the original CUE for the purpose of large-scale research-based assessment. We also compare the details of student responses on each of the two versions. While the CMR version does not capture the full scope of potential student responses, nearly three-quarters of our students’ responses to the free-response version contained one or more elements that matched options provided on the CMR version.

Pathological responses to terrorism.

Science.gov (United States)

Yehuda, Rachel; Bryant, Richard; Marmar, Charles; Zohar, Joseph

2005-10-01

Many important gains have been made in understanding PTSD and other responses to trauma as a result of neuroscience-based observations. Yet there are many gaps in our knowledge that currently impede our ability to predict those who will develop pathologic responses. Such knowledge is essential for developing appropriate strategies for mounting a mental health response in the aftermath of terrorism and for facilitating the recovery of individuals and society. This paper reviews clinical and biological studies that have led to an identification of pathologic responses following psychological trauma, including terrorism, and highlights areas of future-research. It is important to not only determine risk factors for the development of short- and long-term mental health responses to terrorism, but also apply these risk factors to the prediction of such responses on an individual level. It is also critical to consider the full spectrum of responses to terrorism, as well as the interplay between biological and psychological variables that contribute to these responses. Finally, it is essential to remove the barriers to collecting data in the aftermath of trauma by creating a culture of education in which the academic community can communicate to the public what is and is not known so that survivors of trauma and terrorism will understand the value of their participation in research to the generation of useful knowledge, and by maintaining the acquisition of knowledge as a priority for the government and those involved in the immediate delivery of services in the aftermath of large-scale disaster or trauma.

Selective responsiveness: Online public demands and government responsiveness in authoritarian China.

Science.gov (United States)

Su, Zheng; Meng, Tianguang

2016-09-01

The widespread use of information and communication technology (ICT) has reshaped the public sphere in the digital era, making online forums a new channel for political participation. Using big data analytics of full records of citizen-government interactions from 2008 to early 2014 on a nationwide political forum, we find that authoritarian China is considerably responsive to citizens' demands with a rapid growth of response rate; however, government responsiveness is highly selective, conditioning on actors' social identities and the policy domains of their online demands. Results from logistic and duration models suggest that requests which made by local citizens, expressed collectively, focused on the single task issue, and are closely related to economic growth are more likely to be responded to. These strategies adopted by Chinese provincial leaders reveal the scope and selectivity of authoritarian responsiveness. Copyright © 2016 Elsevier Inc. All rights reserved.

Social responsibility and SOE restructuring

Institute of Scientific and Technical Information of China (English)

沈志渔; 刘兴国; 周小虎

2009-01-01

SOE social responsibility has undergone three stages of evolution.In essence,corporate social responsibility includes social obligations and social expectations.Public attention to SOE social responsibility issues has affected the thinking surrounding SOE restructuring,including the promulgating of objectives and methods.Based on corporate social responsibility,SOE managers must set up a perfect SOE social responsibility system and strengthen supervisory mechanisms;in respect to corporate governance models,SOEs should undertake reform for the corporate citizen governance model.

Aligning Responsible Business Practices

DEFF Research Database (Denmark)

Weller, Angeli E.

2017-01-01

This article offers an in-depth case study of a global high tech manufacturer that aligned its ethics and compliance, corporate social responsibility, and sustainability practices. Few large companies organize their responsible business practices this way, despite conceptual relevance and calls t...... and managers interested in understanding how responsible business practices may be collectively organized.......This article offers an in-depth case study of a global high tech manufacturer that aligned its ethics and compliance, corporate social responsibility, and sustainability practices. Few large companies organize their responsible business practices this way, despite conceptual relevance and calls...... to manage them comprehensively. A communities of practice theoretical lens suggests that intentional effort would be needed to bridge meaning between the relevant managers and practices in order to achieve alignment. The findings call attention to the important role played by employees who broker...

Orosensory responsiveness and alcohol behaviour.

Science.gov (United States)

Thibodeau, Margaret; Bajec, Martha; Pickering, Gary

2017-08-01

Consumption of alcoholic beverages is widespread through much of the world, and significantly impacts human health and well-being. We sought to determine the contribution of orosensation ('taste') to several alcohol intake measures by examining general responsiveness to taste and somatosensory stimuli in a convenience sample of 435 adults recruited from six cohorts. Each cohort was divided into quantiles based on their responsiveness to sweet, sour, bitter, salty, umami, metallic, and astringent stimuli, and the resulting quantiles pooled for analysis (Kruskal-Wallis ANOVA). Responsiveness to bitter and astringent stimuli was associated in a non-linear fashion with intake of all alcoholic beverage types, with the highest consumption observed in middle quantiles. Sourness responsiveness tended to be inversely associated with all measures of alcohol consumption. Regardless of sensation, the most responsive quantiles tended to drink less, although sweetness showed little relationship between responsiveness and intake. For wine, increased umami and metallic responsiveness tended to predict lower total consumption and frequency. A limited examination of individuals who abstain from all alcohol indicated a tendency toward higher responsiveness than alcohol consumers to sweetness, sourness, bitterness, and saltiness (biserial correlation), suggesting that broadly-tuned orosensory responsiveness may be protective against alcohol use and possibly misuse. Overall, these findings confirm the importance of orosensory responsiveness in mediating consumption of alcohol, and indicate areas for further research. Copyright © 2017. Published by Elsevier Inc.

Instant responsive web design

CERN Document Server

Simmons, Cory

2013-01-01

A step-by-step tutorial approach which will teach the readers what responsive web design is and how it is used in designing a responsive web page.If you are a web-designer looking to expand your skill set by learning the quickly growing industry standard of responsive web design, this book is ideal for you. Knowledge of CSS is assumed.

Smoking and immunomodulators do not influence the response or duration of response to infliximab in Crohn's disease.

Science.gov (United States)

Fefferman, David S; Lodhavia, Parag J; Alsahli, Mazen; Falchuk, Kenneth R; Peppercorn, Mark A; Shah, Samir A; Farrell, Richard J

2004-07-01

Clinical predictors for infliximab response are still unknown. Identifying predictors of response to infliximab in Crohn's disease may improve our selection of patients. Two hundred patients with luminal (61%) or fistulous (39%) Crohn's disease and at least 6 months of follow-up following a total of 416 infliximab infusions were evaluated. Clinical response and duration of response were the primary endpoints. Patients with fistulous disease had a higher response rate (83% versus 70%, P = 0.044) and a significantly longer duration of response compared with patients with luminal disease (17.4 versus 10.1 wks, P = 0.017). For luminal disease, nonsmokers and smokers had similar response rates (74% versus 64%, P = 0.5) and similar durations of response (9.4 wks versus 8.4 wks P = 0.6) while patients taking concurrent immunomodulators had similar response rates compared with those not taking immunomodulators (74% versus 71%, P = 0.9) and similar durations of response (10.4 wks versus 10.6 wks, P = 0.9). For fistulous disease, response rates (89% versus 83% P = 0.9) and duration of response (16.9 wks versus 10.1 wks, P = 0.10) were similar between nonsmokers and smokers and concurrent immunomodulators had no effect on response (89% versus 86%, P = 0.9) or duration of response (19.8 wks versus 15.4 wks, P = 0.46). Multivariable analysis confirmed that neither smoking, corticosteroids, immunomodulator therapy, gender, age, age of disease onset, disease duration, nor luminal disease location significantly influenced response or duration of response. Patients with fistulous disease had a higher response rate and a significantly longer duration of response compared with patients with luminal disease. However, among patients with luminal or fistulous disease, neither smoking nor immunomodulators had any effect on response or duration of response.

Stress Responses in Staphylococcus aureus

DEFF Research Database (Denmark)

Frees, Dorte; Ingmer, Hanne

2016-01-01

stress responses allowing it to sense and adapt to its very different niches. The stress responses often involve dramatic cellular reprogramming, and the technological advances provided by the access to whole genome sequences have let to an unprecedented insight into the global reorganization of gene...... and protein expression following stress-exposure. Characterization of global gene responses has been very helpful both in identifying regulators sensing specific environmental stress signals and overlaps between different stress responses. In this chapter we review the recent progress in our understanding...... of the specific and general S. aureusstress responses, with a special emphasis on how stress responses contribute to virulence and antibiotic resistance in this important human pathogen....

An overview of the Environmental Response Team's air surveillance procedures at emergency response activities

Energy Technology Data Exchange (ETDEWEB)

Turpin, R.D.; Campagna, P.R. (U.S. Environmental Protection Agency, Edison, NJ (USA))

The Safety and Air Surveillance Section of the United States Environmental Protection Agency's Environmental Response Team responds to emergency air releases such as tire fires and explosions. The air surveillance equipment and procedures used by the organization are described, and case studies demonstrating the various emergency response activities are presented. Air response activities include emergency air responses, occupational and human health air responses and remedial air responses. Monitoring and sampling equipment includes photoionization detectors, combustible gas meters, real-time aerosol monitors, personal sampling pumps, and high flow pumps. Case histories presented include disposal of dioxane from a cotton plant, response to oil well fires in Kuwait, disposal of high pressure cylinders in American Samoa, and response to hurricane Hugo. 3 refs., 1 tab.

State Responsibility in Peacekeeping
The effect of responsibility on future contributions

Directory of Open Access Journals (Sweden)

Nina Mileva

2016-01-01

Full Text Available While the law on state responsibility is a well-developed field in international law, the potential for responsibility on the part of the state as a result of events taking place during peacekeeping missions is a fairly novel phenomenon. Internationally, claims in this field have been brought before the European Court of Human Rights and the International Court of Justice. National courts, on the other hand, have heard a total of six cases on the matter, in Belgium, the UK, and the Netherlands, all eventually apportioning responsibility to the state. This paper explores the effect that the potential for responsibility, as manifested in the outcomes of these recent cases, may have on state behaviour with respect to its future contributions to peacekeeping. The paper combines an exploration of the relevant adjudged cases with views collected from experts and academia in order to formulate three hypotheses on the effect of the potential for responsibility on future state behaviour. These hypotheses are then applied to the example of the Netherlands in the aftermath of a series of decisions finding it responsible for events taking place during its involvement in peacekeeping in Bosnia and Herzegovina in the 1990s. Due to the recent timing of the cases, the paper concludes with preliminary findings on each of the hypotheses, thereby opening the door to future research on the topic.

Dose-response curves from incomplete data

International Nuclear Information System (INIS)

Groer, P.G.

1978-01-01

Frequently many different responses occur in populations (animal or human) exposed to ionizing radiation. To obtain a dose-response curve, the exposed population is first divided into sub-groups whose members received the same radiation dose. To estimate the response, the fraction of subjects in each sub-group that showed the particular response of interest is determined. These fractions are plotted against dose to give the dose-response curve. This procedure of plotting the fractions versus the radiation dose is not the correct way to estimate the time distribution for a particular response at the different dose levels. Other observed responses competed for the individuals in the exposed population and therefore prevented manifestation of the complete information on the response-time distribution for one specific response. Such data are called incomplete in the statistical literature. A procedure is described which uses the by now classical Kaplan-Meier estimator, to establish dose-response curves from incomplete data under the assumption that the different observed responses are statistically independent. It is demonstrated that there is insufficient information in the observed survival functions to estimate the time distribution for one particular response if the assumption of independence is dropped. In addition, it is not possible to determine from the data (i.e. type of response and when it occurred) whether or not the different response-time distributions are independent. However, it is possible to give sharp bounds between which the response has to lie. This implies that for incomplete data, only a 'dose-response band' can be established if independence of the competing responses cannot be assumed. Examples are given using actual data to illustrate the estimation procedures

Using Culturally Responsive Stories in Mathematics: Responses from the Target Audience

Science.gov (United States)

Corp, Amy

2017-01-01

This study examined how Black students responded to the utilization of culturally responsive stories in their mathematics class. All students in the two classes participated in mathematics lessons that began with an African American story (culturally responsive to this population), followed by mathematical discussion and concluded with solving…

Seasonal, spatial, and maternal effects on gut microbiome in wild red squirrels.

Science.gov (United States)

Ren, Tiantian; Boutin, Stan; Humphries, Murray M; Dantzer, Ben; Gorrell, Jamieson C; Coltman, David W; McAdam, Andrew G; Wu, Martin

2017-12-21

Our understanding of gut microbiota has been limited primarily to findings from human and laboratory animals, but what shapes the gut microbiota in nature remains largely unknown. To fill this gap, we conducted a comprehensive study of gut microbiota of a well-studied North American red squirrel (Tamiasciurus hudsonicus) population. Red squirrels are territorial, solitary, and live in a highly seasonal environment and therefore represent a very attractive system to study factors that drive the temporal and spatial dynamics of gut microbiota. For the first time, this study revealed significant spatial patterns of gut microbiota within a host population, suggesting limited dispersal could play a role in shaping and maintaining the structure of gut microbial communities. We also found a remarkable seasonal rhythm in red squirrel's gut microbial composition manifested by a tradeoff between relative abundance of two genera Oscillospira and Corpococcus and clearly associated with seasonal variation in diet availability. Our results show that in nature, environmental factors exert a much stronger influence on gut microbiota than host-associated factors including age and sex. Despite strong environmental effects, we found clear evidence of individuality and maternal effects, but host genetics did not seem to be a significant driver of the gut microbial communities in red squirrels. Taken together, the results of this study emphasize the importance of external ecological factors rather than host attributes in driving temporal and spatial patterns of gut microbiota in natural environment.

Predicting the response of olfactory sensory neurons to odor mixtures from single odor response

OpenAIRE

Marasco, Addolorata; De Paris, Alessandro; Migliore, Michele

2016-01-01

The response of olfactory receptor neurons to odor mixtures is not well understood. Here, using experimental constraints, we investigate the mathematical structure of the odor response space and its consequences. The analysis suggests that the odor response space is 3-dimensional, and predicts that the dose-response curve of an odor receptor can be obtained, in most cases, from three primary components with specific properties. This opens the way to an objective procedure to obtain specific o...

Fitting Diffusion Item Response Theory Models for Responses and Response Times Using the R Package diffIRT

Directory of Open Access Journals (Sweden)

Dylan Molenaar

2015-08-01

Full Text Available In the psychometric literature, item response theory models have been proposed that explicitly take the decision process underlying the responses of subjects to psychometric test items into account. Application of these models is however hampered by the absence of general and flexible software to fit these models. In this paper, we present diffIRT, an R package that can be used to fit item response theory models that are based on a diffusion process. We discuss parameter estimation and model fit assessment, show the viability of the package in a simulation study, and illustrate the use of the package with two datasets pertaining to extraversion and mental rotation. In addition, we illustrate how the package can be used to fit the traditional diffusion model (as it has been originally developed in experimental psychology to data.

Radio-adaptive response

International Nuclear Information System (INIS)

Ikushima, T.

1992-01-01

An adaptive response to radiation stress was found as a suppressed induction of chromosomal damage including micronuclei and sister chromatid exchanges in cultured Chinese hamster V79 cells pre-exposed to very low doses of ionizing radiations. The mechanism underlying this novel chromosomal response, called 'radio-adaptive response (RAR)' has been studied progressively. The following results were obtained in recent experiments. 1. Low doses of β-rays from tritiated water (HTO) as well as tritium-thymidine can cause RAR. 2. Thermal neutrons, a high LET radiation, can not act as tritium β-rays or γ-rays. 3. The RAR expression is suppressed not only by the treatment with an inhibitor of protein synthesis but also by RNA synthesis inhibition. 4. Several proteins are newly synthesized concurrently with the RAR expression after the adapting doses, viewed by two-dimensional electrophoresis of cellular proteins. These results suggests that the RAR might be a cellular stress response to a signal produced preferentially by very low doses of low LET radiation under restricted conditions, accompany the inducible specific gene expression. (author)

Biomolecule-Responsive Hydrogels in Medicine.

Science.gov (United States)

Sharifzadeh, Ghorbanali; Hosseinkhani, Hossein

2017-12-01

Recent advances and applications of biomolecule-responsive hydrogels, namely, glucose-responsive hydrogels, protein-responsive hydrogels, and nucleic-acid-responsive hydrogels are highlighted. However, achieving the ultimate purpose of using biomolecule-responsive hydrogels in preclinical and clinical areas is still at the very early stage and calls for more novel designing concepts and advance ideas. On the way toward the real/clinical application of biomolecule-responsive hydrogels, plenty of factors should be extensively studied and examined under both in vitro and in vivo conditions. For example, biocompatibility, biointegration, and toxicity of biomolecule-responsive hydrogels should be carefully evaluated. From the living body's point of view, biocompatibility is seriously depended on the interactions at the tissue/polymer interface. These interactions are influenced by physical nature, chemical structure, surface properties, and degradation of the materials. In addition, the developments of advanced hydrogels with tunable biological and mechanical properties which cause no/low side effects are of great importance. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Structural building response review

International Nuclear Information System (INIS)

1980-01-01

The integrity of a nuclear power plant during a postulated seismic event is required to protect the public against radiation. Therefore, a detailed set of seismic analyses of various structures and equipment is performed while designing a nuclear power plant. This report describes the structural response analysis method, including the structural model, soil-structure interaction as it relates to structural models, methods for seismic structural analysis, numerical integration methods, methods for non-seismic response analysis approaches for various response combinations, structural damping values, nonlinear response, uncertainties in structural properties, and structural response analysis using random properties. The report describes the state-of-the-art in these areas for nuclear power plants. It also details the past studies made at Sargent and Lundy to evaluate different alternatives and the conclusions reached for the specific purposes that those studies were intended. These results were incorporated here because they fall into the general scope of this report. The scope of the present task does not include performing new calculations

In response to community violence: coping strategies and involuntary stress responses among Latino adolescents.

Science.gov (United States)

Epstein-Ngo, Quyen; Maurizi, Laura K; Bregman, Allyson; Ceballo, Rosario

2013-01-01

Among poor, urban adolescents, high rates of community violence are a pressing public health concern. This study relies on a contextual framework of stress and coping to investigate how coping strategies and involuntary stress responses may both mediate and moderate the relation between exposure to community violence and psychological well-being. Our sample consists of 223 ninth grade Latino adolescents from poor, urban families. In response to community violence, these adolescents reported using an array of coping strategies as well as experiencing a number of involuntary stress responses; the most frequent coping responses were turning to religion and seeking social support. Hierarchical regression analyses demonstrated that involuntary stress responses mediated the relations between both witnessing or being victimized by violence and poorer psychological functioning, while coping strategies moderated these relations. These findings suggest that the negative psychological effects of exposure to community violence may, in part, be explained by involuntary stress responses, while religious-based coping may serve as a protective factor.

Exacting Responses: Lack of Endocrine Cephalic Phase Responses Upon Oro-Sensory Exposure

Directory of Open Access Journals (Sweden)

Marlou P. Lasschuijt

2018-06-01

Full Text Available Oro-sensory exposure (OSE to food plays an important role in the regulation of food intake. One proposed underlying mechanism is the occurrence of cephalic phase responses (CPRs. CPRs include the pre-digestive endocrine responses induced by food-related sensory input. Yet, whether OSE duration or sweetness intensity affects CPRs is unknown. The objective of this study was to determine the independent and interactive effects of oro-sensory duration (chewing and stimulation intensity (sweetness on endocrine CPRs and satiation. Eighteen males (22 ± 2 years, BMI 22 ± 2 kg/m2 participated in a 2 × 2 randomized study with a control condition. Each session participants performed modified sham feeding (MSF with one of the four gel-based model foods. During the control session no MSF was performed. Model foods differed in chewing duration (hard or soft texture and sweetness (low or high intensity. During each session, eight blood samples were collected up till 25 min after MSF onset. Subsequently, food intake from an ad libitum lunch was measured. No typical CPR was found for insulin, pancreatic polypeptide (PP, and ghrelin. However, the overall PP response was 1.1 times greater for the hard sweet MSF condition compared to control (p = 0.02. Overall ghrelin responses were 1.1 times greater for the hard model food compared to the soft model food conditions (p = 0.003. These differences in endocrine response were not associated with differences in food intake at the subsequent meal. Exploratory sub-analysis of the responsive insulin curves showed that after 2.5 min of MSF the hard texture model foods insulin concentrations were 1.2 greater compared to the soft texture. These findings indicate that texture hardness and sweetness increase the overall PP response and that MSF on hard texture increases the overall ghrelin response compared to soft texture model foods. However, MSF on model foods does not lead to a typical CPR

Responsibility and climate change

OpenAIRE

Jamieson, Dale

2015-01-01

Ibegin by providing some background to conceptions of responsibility. I note the extent of disagreement in this area, the diverse and cross-cutting distinctions that are deployed, and the relative neglect of some important problems. These facts make it difficult to attribute responsibility for climate change, but so do some features of climate change itself which I go on to illuminate. Attributions of responsibility are often contested sites because such attributions are fundamentally pragmat...

Response capabilities of the National Guard: a focus on domestic disaster medical response.

Science.gov (United States)

Bochicchio, Daniel

2010-01-01

The National Guard has a 373-year history of responding to the nation's call to duty for service both at home and abroad (The National Guard Bureau Web site: Available at http://www.ngb.army.mil/default. aspx.). The National Guard (NG) is a constitutionally unique organization (United States Constitution, US Government Printing Office Web site: Available at http://www.gpoaccess.gov/constitution/index.html.). Today's Guard conducts domestic disaster response and civilian assistance missions on a daily basis. Yet, the NG's role, mission, and capabilities are not well-known or understood. The National Response Framework (NRF) places significant responsibility on the local and state disaster planners (Department of Homeland Security: National Response Framework. US Department of Homeland Security, Washington, DC, January 2008). The public health professionals are an integral component of the disaster planning community. It is critical that the public health community be knowledgeable of types and capabilities of all the response assets at their disposal.

THE IMPACTS OF PHILANTHROPY RESPONSIBILITY AND ETHICAL RESPONSIBILITY TOWARD CUSTOMER PURCHASE BEHAVIOR AND CUSTOMER LOYALTY

Directory of Open Access Journals (Sweden)

Kurniawati Chrisjatmiko

2018-02-01

Full Text Available The purpose of this research is to analyze the impact of philanthropy responsibility and ethical responsibility towards customer purchase behavior and customer loyalty on fast food restaurants. The research was conducted by using quantitative research design and hypothetical testing to explore philanthropic responsibility, ethical responsibility, customer purchase behavior, and customer loyalty variables. Samples were taken from 186 respondents of employee population in Jakarta. Structural equation modeling was used in order to test the proposed hypotheses. Research result showed the positive and significant impact of philanthropic responsibility towards customer purchase behavior. On contrary, there was no positive ethical responsibility impact found towards customer purchase behavior. These findings are supported by the fact that the majority of consumers purchased fast food base on impulsive buying and not driven by the fast food restaurants ethically responsible behavior. However, the research does show a positive and significant impact of customer purchase behavior on customer loyalty. Further research recommendation should be taken from more respondents in a broader population area. Companies are suggested to approach a strategic and relevant caused-related marketing and caused promotions in relation to philanthropy responsibility to increase customer purchase behavior.

Comparison of LMFBR piping response obtained using response spectrum and time history methods

International Nuclear Information System (INIS)

Hulbert, G.M.

1981-04-01

The dynamic response to a seismic event is calculated for a piping system using a response spectrum analysis method and two time history analysis methods. The results from the analytical methods are compared to identify causes for the differences between the sets of analytical results. Comparative methods are also presented which help to gain confidence in the accuracy of the analytical methods in predicting piping system structure response during seismic events

Relationships among Sensory Responsiveness, Anxiety, and Ritual Behaviors in Children with and without Atypical Sensory Responsiveness.

Science.gov (United States)

Bart, Orit; Bar-Shalita, Tami; Mansour, Hanin; Dar, Reuven

2017-08-01

To explore relationships between sensory responsiveness, anxiety, and ritual behaviors in boys with typical and atypical sensory responsiveness. Forty-eight boys, ages 5-9 participated in the study (28 boys with atypical sensory responsiveness and 20 controls). Atypical sensory responsiveness was defined as a score of ≤154 on the Short Sensory Profile. Parents completed the Sensory Profile, the Screen for Child Anxiety Related Emotional Disorders, and the Childhood Routines Inventory. Children with atypical sensory responsiveness had significantly higher levels of anxiety and a higher frequency of ritual behaviors than controls. Atypical sensory responsiveness was significantly related to both anxiety and ritual behaviors, with anxiety mediating the relationship between sensory modulation and ritual behaviors. The findings elucidate the potential consequences of atypical sensory responsiveness and could support the notion that ritual behaviors develop as a coping mechanism in response to anxiety stemming from primary difficulty in modulating sensory input.

The duration of response inhibition in the stop-signal paradigm varies with response force

NARCIS (Netherlands)

van den Wildenberg, W.P.M.; van Boxtel, G.J.M.; van der Molen, M.

2003-01-01

In a previous study, we have found that the speed of stopping a response is delayed when response readiness is reduced by cuing the probability of no-go trials [Acta Psychol. 111 (2002) 155]. Other investigators observed that responses are more forceful when the probability to respond is low than

Global business, global responsibilities : Corporate social responsibility orientations within a multinational bank

NARCIS (Netherlands)

van den Heuvel, G.G.A.; Soeters, J.M.M.L.; Goessling, T.

2014-01-01

This study examines the effects of culture, gender, and function on orientation toward corporate social responsibility (CSR) among 416 employees of an international financial service organization. The main objective of the study is to investigate the variation of corporate social responsibility

THE IMPACTS OF PHILANTHROPY RESPONSIBILITY AND ETHICAL RESPONSIBILITY TOWARD CUSTOMER PURCHASE BEHAVIOR AND CUSTOMER LOYALTY

OpenAIRE

Kurniawati Chrisjatmiko; Danthy Margareth

2018-01-01

The purpose of this research is to analyze the impact of philanthropy responsibility and ethical responsibility towards customer purchase behavior and customer loyalty on fast food restaurants. The research was conducted by using quantitative research design and hypothetical testing to explore philanthropic responsibility, ethical responsibility, customer purchase behavior, and customer loyalty variables. Samples were taken from 186 respondents of employee population in Jakarta. Structural eq...

Demand response in energy markets

International Nuclear Information System (INIS)

Skytte, K.; Birk Mortensen, J.

2004-11-01

Improving the ability of energy demand to respond to wholesale prices during critical periods of the spot market can reduce the total costs of reliably meeting demand, and the level and volatility of the prices. This fact has lead to a growing interest in the short-run demand response. There has especially been a growing interest in the electricity market where peak-load periods with high spot prices and occasional local blackouts have recently been seen. Market concentration at the supply side can result in even higher peak-load prices. Demand response by shifting demand from peak to base-load periods can counteract the market power in the peak-load. However, demand response has so far been modest since the current short-term price elasticity seems to be small. This is also the case for related markets, for example, green certificates where the demand is determined as a percentage of the power demand, or for heat and natural gas markets. This raises a number of interesting research issues: 1) Demand response in different energy markets, 2) Estimation of price elasticity and flexibility, 3) Stimulation of demand response, 4) Regulation, policy and modelling aspects, 5) Demand response and market power at the supply side, 6) Energy security of supply, 7) Demand response in forward, spot, ancillary service, balance and capacity markets, 8) Demand response in deviated markets, e.g., emission, futures, and green certificate markets, 9) Value of increased demand response, 10) Flexible households. (BA)

Hormonal modulation of the heat shock response: insights from fish with divergent cortisol stress responses

DEFF Research Database (Denmark)

LeBlanc, Sacha; Höglund, Erik; Gilmour, Kathleen M.

2012-01-01

shock response, we capitalized on two lines of rainbow trout specifically bred for their high (HR) and low (LR) cortisol response to stress. We predicted that LR fish, with a low cortisol but high catecholamine response to stress, would induce higher levels of HSPs after acute heat stress than HR trout....... We found that HR fish have significantly higher increases in both catecholamines and cortisol compared with LR fish, and LR fish had no appreciable stress hormone response to heat shock. This unexpected finding prevented further interpretation of the hormonal modulation of the heat shock response...

Personal Responsibility and Lifestyle Diseases

DEFF Research Database (Denmark)

Andersen, Martin Marchman; Nielsen, Morten Ebbe Juul

2016-01-01

What does it take for an individual to be personally responsible for behaviors that lead to increased risk of disease? We examine three approaches to responsibility that cover the most important aspects of the discussion of responsibility and spell out what it takes, according to each of them......, to be responsible for behaviors leading to increased risk of disease. We show that only what we call the causal approach can adequately accommodate widely shared intuitions to the effect that certain causal influences—such as genetic make-up or certain social circumstances—diminish, or undermine personal...... risk of disease rests on premises so shaky that personal responsibility is probably impossible....

Consumers' physiological and verbal responses towards product packages: Could these responses anticipate product choices?

Science.gov (United States)

Vila-López, Natalia; Küster-Boluda, Inés

2018-03-03

Today, it is a priority to predict what consumers will choose at the point of sale where there are more and more competing brands. But what kind of consumers' information can be used for that purpose? This paper compares the power of physiological responses (unconscious responses) and self-report/verbal responses (conscious responses) towards product packages, as a means of predicting product choices. To this end, six different packaging designs were created by combining three different colors (blue, red and black) and two different messages (simple and reinforced). Eighty-three young consumers were exposed to each of the six designs. In one phase of our investigation, unconscious electrodermal activity (EDA) for each participant and each packaging type was recorded. In another phase, conscious verbal opinions for each packaging type were collected in a questionnaire. Our results show that the blue packaging with a reinforced message was most often selected. For this packaging consumers' electrodermal values (unconscious responses) were lower, and verbal opinions (conscious responses) were higher. Thus, both data sets could be used to anticipate product choice. However, for the other five packages, only unconscious responses were related to product choices. In contrast, higher opinions in a questionnaire did not correspond to selection of packages. Copyright © 2018. Published by Elsevier Inc.

Non-response to (statin) therapy

DEFF Research Database (Denmark)

Trompet, S; Postmus, I; Slagboom, P E

2016-01-01

PURPOSE: In pharmacogenetic research, genetic variation in non-responders and high responders is compared with the aim to identify the genetic loci responsible for this variation in response. However, an important question is whether the non-responders are truly biologically non-responsive......-responders from the analysis. RESULTS: Non-responders to statin therapy were younger (p = 0.001), more often smoked (p levels (p ... that non-adherence is investigated instead of non-responsiveness....

Modularization and Response Curve Engineering of a Naringenin-Responsive Transcriptional Biosensor.

Science.gov (United States)

De Paepe, Brecht; Maertens, Jo; Vanholme, Bartel; De Mey, Marjan

2018-05-18

To monitor the intra- and extracellular environment of micro-organisms and to adapt their metabolic processes accordingly, scientists are reprogramming nature's myriad of transcriptional regulatory systems into transcriptional biosensors, which are able to detect small molecules and, in response, express specific output signals of choice. However, the naturally occurring response curve, the key characteristic of biosensor circuits, is typically not in line with the requirements for real-life biosensor applications. In this contribution, a natural LysR-type naringenin-responsive biosensor circuit is developed and characterized with Escherichia coli as host organism. Subsequently, this biosensor is dissected into a clearly defined detector and effector module without loss of functionality, and the influence of the expression levels of both modules on the biosensor response characteristics is investigated. Two collections of ten unique synthetic biosensors each are generated. Each collection demonstrates a unique diversity of response curve characteristics spanning a 128-fold change in dynamic and 2.5-fold change in operational ranges and 3-fold change in levels of Noise, fit for a wide range of applications, such as adaptive laboratory evolution, dynamic pathway control and high-throughput screening methods. The established biosensor engineering concepts, and the developed biosensor collections themselves, are of use for the future development and customization of biosensors in general, for the multitude of biosensor applications and as a compelling alternative for the commonly used LacI-, TetR- and AraC-based inducible circuits.

Corporate responses to stakeholder activism

DEFF Research Database (Denmark)

Uldam, Julie; Krause Hansen, Hans

2017-01-01

Corporations are increasingly expected to act responsibly. The purpose of this paper is to examine two types of corporate responses to these expectations: overt and covert responses. Specifically, it examines oil companies’ involvement in multi-stakeholder initiatives and sponsorships (overt...

A heteroscedastic generalized linear model with a non-normal speed factor for responses and response times.

Science.gov (United States)

Molenaar, Dylan; Bolsinova, Maria

2017-05-01

In generalized linear modelling of responses and response times, the observed response time variables are commonly transformed to make their distribution approximately normal. A normal distribution for the transformed response times is desirable as it justifies the linearity and homoscedasticity assumptions in the underlying linear model. Past research has, however, shown that the transformed response times are not always normal. Models have been developed to accommodate this violation. In the present study, we propose a modelling approach for responses and response times to test and model non-normality in the transformed response times. Most importantly, we distinguish between non-normality due to heteroscedastic residual variances, and non-normality due to a skewed speed factor. In a simulation study, we establish parameter recovery and the power to separate both effects. In addition, we apply the model to a real data set. © 2017 The Authors. British Journal of Mathematical and Statistical Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

What Does It Mean To Be Responsible? Addressing the Missing Responsibility Dimension in Ethical Leadership

OpenAIRE

Voegtlin Christian

2016-01-01

International audience; This paper extends research on ethical leadership by proposing a responsibility orientation for leaders. Responsible leadership is based on the concept of leaders who are not isolated from the environment, who critically evaluate prevailing norms, are forward-looking, share responsibility, and aim to solve problems collectively. Adding such a responsibility orientation helps to address critical issues that persist in research on ethical leadership. The paper discusses ...

Who is More Responsible? Preparatory Class Students’ Perceptions of Responsibility

OpenAIRE

Cesur, Kürşat; Ertaş, Abdullah

2014-01-01

 The main aim of this study is to explore learners’ perceptions of their own responsibility in learning English. The question of whether our learners in Canakkale Onsekiz Mart University (hereafter COMU) Compulsory and Voluntary English Language Prep Classes are responsible enough for their own learning or not is the main focus of this study. Whether some variables like gender, the type of the prep class education (compulsory or voluntary) and the students’ departments will affect their perce...

Overlearned responses hinder S-R binding.

Science.gov (United States)

Moeller, Birte; Frings, Christian

2017-01-01

Two mechanisms that are important for human action control are the integration of individual action plans (see Hommel, Müsseler, Aschersleben, & Prinz, 2001) and the automatization of overlearned actions to familiar stimuli (see Logan, 1988). In the present study, we analyzed the influence of automatization on action plan integration. Integration with pronunciation responses were compared for response incompatible word and nonword stimuli. Stimulus-response binding effects were observed for nonwords. In contrast, words that automatically triggered an overlearned pronunciation response were not integrated with pronunciation of a different word. That is, automatized response retrieval hindered binding effects regarding the retrieving stimulus and a new response. The results are a first indication of the way that binding and learning processes interact, and might also be a first step to understanding the more complex interdependency of the processes responsible for stimulus-response binding in action control and stimulus-response associations in learning research. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Responses in large-scale structure

Energy Technology Data Exchange (ETDEWEB)

Barreira, Alexandre; Schmidt, Fabian, E-mail: barreira@MPA-Garching.MPG.DE, E-mail: fabians@MPA-Garching.MPG.DE [Max-Planck-Institut für Astrophysik, Karl-Schwarzschild-Str. 1, 85741 Garching (Germany)

2017-06-01

We introduce a rigorous definition of general power-spectrum responses as resummed vertices with two hard and n soft momenta in cosmological perturbation theory. These responses measure the impact of long-wavelength perturbations on the local small-scale power spectrum. The kinematic structure of the responses (i.e., their angular dependence) can be decomposed unambiguously through a ''bias'' expansion of the local power spectrum, with a fixed number of physical response coefficients , which are only a function of the hard wavenumber k . Further, the responses up to n -th order completely describe the ( n +2)-point function in the squeezed limit, i.e. with two hard and n soft modes, which one can use to derive the response coefficients. This generalizes previous results, which relate the angle-averaged squeezed limit to isotropic response coefficients. We derive the complete expression of first- and second-order responses at leading order in perturbation theory, and present extrapolations to nonlinear scales based on simulation measurements of the isotropic response coefficients. As an application, we use these results to predict the non-Gaussian part of the angle-averaged matter power spectrum covariance Cov{sup NG}{sub ℓ=0}( k {sub 1}, k {sub 2}), in the limit where one of the modes, say k {sub 2}, is much smaller than the other. Without any free parameters, our model results are in very good agreement with simulations for k {sub 2} ∼< 0.06 h Mpc{sup −1}, and for any k {sub 1} ∼> 2 k {sub 2}. The well-defined kinematic structure of the power spectrum response also permits a quick evaluation of the angular dependence of the covariance matrix. While we focus on the matter density field, the formalism presented here can be generalized to generic tracers such as galaxies.

Responses in large-scale structure

Science.gov (United States)

Barreira, Alexandre; Schmidt, Fabian

2017-06-01

We introduce a rigorous definition of general power-spectrum responses as resummed vertices with two hard and n soft momenta in cosmological perturbation theory. These responses measure the impact of long-wavelength perturbations on the local small-scale power spectrum. The kinematic structure of the responses (i.e., their angular dependence) can be decomposed unambiguously through a ``bias'' expansion of the local power spectrum, with a fixed number of physical response coefficients, which are only a function of the hard wavenumber k. Further, the responses up to n-th order completely describe the (n+2)-point function in the squeezed limit, i.e. with two hard and n soft modes, which one can use to derive the response coefficients. This generalizes previous results, which relate the angle-averaged squeezed limit to isotropic response coefficients. We derive the complete expression of first- and second-order responses at leading order in perturbation theory, and present extrapolations to nonlinear scales based on simulation measurements of the isotropic response coefficients. As an application, we use these results to predict the non-Gaussian part of the angle-averaged matter power spectrum covariance CovNGl=0(k1,k2), in the limit where one of the modes, say k2, is much smaller than the other. Without any free parameters, our model results are in very good agreement with simulations for k2 lesssim 0.06 h Mpc-1, and for any k1 gtrsim 2k2. The well-defined kinematic structure of the power spectrum response also permits a quick evaluation of the angular dependence of the covariance matrix. While we focus on the matter density field, the formalism presented here can be generalized to generic tracers such as galaxies.

A simplified multisupport response spectrum method

Science.gov (United States)

Ye, Jihong; Zhang, Zhiqiang; Liu, Xianming

2012-03-01

A simplified multisupport response spectrum method is presented. The structural response is a sum of two components of a structure with a first natural period less than 2 s. The first component is the pseudostatic response caused by the inconsistent motions of the structural supports, and the second is the structural dynamic response to ground motion accelerations. This method is formally consistent with the classical response spectrum method, and the effects of multisupport excitation are considered for any modal response spectrum or modal superposition. If the seismic inputs at each support are the same, the support displacements caused by the pseudostatic response become rigid body displacements. The response spectrum in the case of multisupport excitations then reduces to that for uniform excitations. In other words, this multisupport response spectrum method is a modification and extension of the existing response spectrum method under uniform excitation. Moreover, most of the coherency coefficients in this formulation are simplified by approximating the ground motion excitation as white noise. The results indicate that this simplification can reduce the calculation time while maintaining accuracy. Furthermore, the internal forces obtained by the multisupport response spectrum method are compared with those produced by the traditional response spectrum method in two case studies of existing long-span structures. Because the effects of inconsistent support displacements are not considered in the traditional response spectrum method, the values of internal forces near the supports are underestimated. These regions are important potential failure points and deserve special attention in the seismic design of reticulated structures.

Responsible Reporting: Neuroimaging News in the Age of Responsible Research and Innovation.

Science.gov (United States)

de Jong, Irja Marije; Kupper, Frank; Arentshorst, Marlous; Broerse, Jacqueline

2016-08-01

Besides offering opportunities in both clinical and non-clinical domains, the application of novel neuroimaging technologies raises pressing dilemmas. 'Responsible Research and Innovation' (RRI) aims to stimulate research and innovation activities that take ethical and social considerations into account from the outset. We previously identified that Dutch neuroscientists interpret "responsible innovation" as educating the public on neuroimaging technologies via the popular press. Their aim is to mitigate (neuro)hype, an aim shared with the wider emerging RRI community. Here, we present results of a media-analysis undertaken to establish whether the body of articles in the Dutch popular press presents balanced conversations on neuroimaging research to the public. We found that reporting was mostly positive and framed in terms of (healthcare) progress. There was rarely a balance between technology opportunities and limitations, and even fewer articles addressed societal or ethical aspects of neuroimaging research. Furthermore, neuroimaging metaphors seem to favour oversimplification. Current reporting is therefore more likely to enable hype than to mitigate it. How can neuroscientists, given their self-ascribed social responsibility, address this conundrum? We make a case for a collective and shared responsibility among neuroscientists, journalists and other stakeholders, including funders, committed to responsible reporting on neuroimaging research.

Corporate social responsibility in hospitality

Directory of Open Access Journals (Sweden)

Snježana Gagić

2016-01-01

Full Text Available Responsible management of global hospitality companies increasingly recognizes how important are concerns about the society, the environment as well as all stakeholders in maintaining a good market position. In Serbia, the concept of corporate social responsibility is relatively unknown and insufficiently researched in all business areas, especially in the hospitality industry where small businesses are dominated. The papers task is to present particular activities that demonstrate social responsibility to employees, customers-guests, local communities as well as the environment. The paper aims to highlight the benefits of adopting the principles of corporate social responsibility and innovation applied in catering enterprises as an example of good corporate social responsibility practices.

Immune responses to metastases

International Nuclear Information System (INIS)

Herberman, R.B.; Wiltrout, R.H.; Gorelik, E.

1987-01-01

The authors present the changes in the immune system in tumor-bearing hosts that may influence the development of progression of metastases. Included are mononuclear cell infiltration of metastases; alterations in natural resistance mediated by natural killer cells and macrophages; development of specific immunity mediated by T-lymphocytes or antibodies; modulation of tumor-associated antigen expression; and the down-regulation of the immune response to the tumor by several suppressor mechanisms; the augmentation of the immune response and its potential for therapeutic application; includes the prophylaxis of metastases formation by NK cells; the therapy of metastases by augmentation NK-, macrophage-, or T-lymphocyte-mediated responses by biological response modifiers; and the transfer of anticancer activity by cytoxic T-lymphocytes or immunoconjugates of monoclonal antibodies with specificity for tumors

Radio-adaptive response

International Nuclear Information System (INIS)

Ikushima, T.

1992-01-01

Knowledge about cellular events in mammalian cells exposed to low doses of ionizing radiation is meager. Recent works showed that human lymphocytes become resistant to radiation-induced chromosomal damage after exposure to low doses of ionizing radiation. Experimental evidence for radio-adaptive response (RAR) in cultured mammalian cells was obtained. Exposure to very low doses of gamma-rays or tritium beta-rays make cells less susceptible to the induction of micronuclei and sister chromatid exchanges by subsequent higher doses. Many important characteristics of the novel response suggest that RAR is a stress response resulting in the enhanced repair of chromosomal DNA damage in cell under restricted conditions. Experiments are still in progress in order to elucidate the molecular basis for RAR processes. (author). 13 refs.; 2 figs., 1 tab

Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees

Science.gov (United States)

Faughn, Carley; Marrus, Natasha; Pruett, John R.; Shuman, Jeremy; Ross, Stephen R.; Constantino, John N.; Povinelli, Daniel J.

2017-01-01

Comparative studies of social responsiveness, a core impairment in autism spectrum disorder (ASD), will enhance our understanding of typical and atypical social behavior. We previously reported a quantitative, cross-species (human–chimpanzee) social responsiveness measure, which included the development of the Chimpanzee Social Responsiveness Scale (CSRS). Here, we augment our prior CSRS sample with 25 zoo chimpanzees at three sites: combined N = 54. The CSRS demonstrated strong interrater reliability, and low-ranked chimpanzees, on average, displayed higher CSRS scores. The CSRS continues to discriminate variation in chimpanzee social responsiveness, and the association of higher scores with lower chimpanzee social standing has implications for the relationship between autistic traits and human social status. Continued comparative investigations of social responsiveness will enhance our understanding of underlying impairments in ASD, improve early diagnosis, and inform future therapies. PMID:25312279

Emotional response towards food packaging

DEFF Research Database (Denmark)

Liao, Lewis Xinwei; Corsi, Armando M.; Chrysochou, Polymeros

2015-01-01

In this paper we investigate consumers’ emotional responses to food packaging. More specifically, we use self-report and physiological measures to jointly assess emotional responses to three typical food packaging elements: colours (lowwavelength vs. high-wavelength), images (positive vs. negative...... response that can only be measured by self-report measures. We propose that a joint application of selfreport and physiological measures can lead to richer information and wider interpretation of consumer emotional responses to food packaging elements than using either measure alone....

Social Responsibility of Hospitality Industry Enterprises

Directory of Open Access Journals (Sweden)

Nuray Türker

2013-09-01

Full Text Available The main aim of this study is to determine the views of employees and managers working at the hospitality industry in Safranbolu towards the social responsibility of tourism enterprises, social responsibility activities carried out by the hotel enterprises, and their views on the advantages and contributions of social responsibility projects to the hotel business. This study will make contributions to the related literature on social responsibility at the hospitality industry by means of identifying the social responsibility activities of hotel enterprises, of which there is relatively limited number of studies.Within this context, a structured survey was conducted with 152 respondents including employees, managers and owners of the hotel enterprises through face to face interviews in order to determine the perceptions of employees towards social responsibility. SPSS 15 for Windows was used to analyze the data. The research has found that the employees working at hospitality industry in Safranbolu are sensitive to the social responsibilities and they act socially responsible in their activities. Additionally the results show that the respondents behave socially responsible towards guests, society and natural environment, but that they are less responsible towards the suppliers.

32 CFR 734.4 - Responsibilities.

Science.gov (United States)

2010-07-01

... MILITARY AND CIVILIAN PERSONNEL FOR COLLECTION OF CHILD SUPPORT AND ALIMONY § 734.4 Responsibilities. (a... 32 National Defense 5 2010-07-01 2010-07-01 false Responsibilities. 734.4 Section 734.4 National... process or other circumstances requiring such action. (b) Command responsibility. (1) The Commanding...

Pushing the Margins of Responsibility

DEFF Research Database (Denmark)

Santoni de Sio, Filippo; Di Nucci, Ezio

2018-01-01

David Shoemaker has claimed that a binary approach to moral responsibility leaves out something important, namely instances of marginal agency, cases where agents seem to be eligible for some responsibility responses but not others. In this paper we endorse and extend Shoemaker’s approach by pres...

Pilot program: NRC severe reactor accident incident response training manual: US Nuclear Regulatory Commission response

International Nuclear Information System (INIS)

Sakenas, C.A.; McKenna, T.J.; Perkins, K.; Miller, C.W.; Hively, L.M.; Sharpe, R.W.; Giitter, J.G.; Watkins, R.M.

1987-02-01

This pilot training manual has been written to fill the need for a general text on NRC response to reactor accidents. The manual is intended to be the foundation for a course for all NRC response personnel. US Nuclear Regulatory Commission Response is the fifth in a series of volumes that collectively summarize the US Nuclear Regulatory Commission (NRC) emergency response during severe power reactor accidents and provide necessary background information. This volume describes NRC response modes, organizations, and official positions; roles of other federal agencies are also described briefly. Each volume serves, respectively, as the text for a course of instruction in a series of courses for NRC response personnel. These materials do not provide guidance or license requirements for NRC licensees. Each volume is accompanied by an appendix of slides that can be used to present this material. The slides are called out in the text

Decoupling Responsible Management Education

DEFF Research Database (Denmark)

Rasche, Andreas; Gilbert, Dirk Ulrich

Business schools increasingly aim to embed corporate responsibility, sustainability, and ethics into their curricular and extracurricular activities. This paper examines under what conditions business schools may decouple the structural effects of their engagement in responsible management educat...

Using item response theory to measure extreme response style in marketing research

NARCIS (Netherlands)

de Jong, Martijn G.; Steenkamp, Jan-Benedict E.M.; Fox, Gerardus J.A.; Baumgartner, Hans

2008-01-01

Extreme response style (ERS) is an important threat to the validity of survey-based marketing research. In this article, the authors present a new item response theory–based model for measuring ERS. This model contributes to the ERS literature in two ways. First, the method improves on existing

Nano-industry operationalizations of "responsibility"

DEFF Research Database (Denmark)

Shelley-Egan, Clare; Davies, Sarah Rachael

2013-01-01

and the United States in order to map industry operationalizations of "responsibility" in these contexts. We show that a number of different articulations of "responsibility" are present, including as a response to public lack of trust and perceived public pressure, and as the management of risk. We close...

CORPORATE SOCIAL RESPONSIBILITY: A CONCEPTUAL OVERVIEW

OpenAIRE

Ozan Büyükyılmaz; Yahya Fidan

2016-01-01

Corporate social responsibility includes the activities performed by enterprises that going beyond the legitimate expectations and carried out on a voluntary basis to improve the social and environmental well-being. In this study, the concept of corporate social responsibility is examined within the frame of definition and content, social responsibility theories, causes that enterprises are moving to social responsibility activities and the scope of social responsibility. It is intended to...

29 CFR 99.400 - Responsibilities.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Responsibilities. 99.400 Section 99.400 Labor Office of the... Pass-through Entities § 99.400 Responsibilities. (a) Cognizant agency for audit responsibilities... the report submission due date required by § 99.320(a). The cognizant agency for audit may grant...

32 CFR 291.5 - Responsibilities.

Science.gov (United States)

2010-07-01

... Responsibilities. (a) The Director, DNA, as appellate authority, is responsible for reviewing and making the final decision on FOIA appeals. (b) The DDIR, as IDA, is responsible for reviewing all initial denials to FOIA...) Forwarding all fees collected under the FOIA to the HQ, DNA, Finance and Accounting Officer for further...

Psychophysiological responses to Salsa dance.

Directory of Open Access Journals (Sweden)

Laura Guidetti

Full Text Available Speculation exists whether dance provides physiological stimuli adequate to promote health and fitness benefits. Unfortunately, research to date has not addressed the affective and exertional responses to dance. These responses are of interest as positive affective and exertional responses experienced during physical activity may play an important role in predicting adherence. The present study aims to examine the psychophysiological responses of different Salsa dance styles. Ten pairs of dancers performed two different structured lessons of Salsa dance, including Typical Salsa and Rueda de Casino lessons, and a non-structured Salsa dance at a night club. Physiological responses (i.e., percent of heart rate reserve; %HRR were continuously assessed and perceived exertion and affective valence were rated every 15 min throughout the trials. %HRR responses differed between the Salsa dance styles (%HRR from 41.3 to 51.9%, and participants were dancing at intensities near their ventilatory threshold. Specifically, Typical Salsa lesson elicited lower %HRR responses than Rueda de Casino lesson (p 0.05. Surprisingly, exertional (from 8 to 11 and affective (from +3 to +5 responses were unaffected by Salsa dance styles (p > 0.05. These data support that different Salsa dance styles provide physiological stimuli adequate to promote health and fitness benefits, and perhaps more importantly, produce pleasurable experiences, which in turn might lead to an increase in adherence to Salsa dancing which likely provides exercise-like health benefits.

The Complex Reasons for Missing Spirituality. A Response to "Democratic Foundations for Spiritually Responsive Pedagogy"

Science.gov (United States)

de Souza, Marian

2017-01-01

This article is written in response to Lingley's (2016) concept of spiritually responsive pedagogy. To begin with, the word "spiritual", when applied to education, still attracts varied responses. Therefore, I have begun by examining contemporary understandings of spirituality as reflected in current research and literature, which…

Time response for sensor sensed to actuator response for mobile robotic system

Science.gov (United States)

Amir, N. S.; Shafie, A. A.

2017-11-01

Time and performance of a mobile robot are very important in completing the tasks given to achieve its ultimate goal. Tasks may need to be done within a time constraint to ensure smooth operation of a mobile robot and can result in better performance. The main purpose of this research was to improve the performance of a mobile robot so that it can complete the tasks given within time constraint. The problem that is needed to be solved is to minimize the time interval between sensor detection and actuator response. The research objective is to analyse the real time operating system performance of sensors and actuators on one microcontroller and on two microcontroller for a mobile robot. The task for a mobile robot for this research is line following with an obstacle avoidance. Three runs will be carried out for the task and the time between the sensors senses to the actuator responses were recorded. Overall, the results show that two microcontroller system have better response time compared to the one microcontroller system. For this research, the average difference of response time is very important to improve the internal performance between the occurrence of a task, sensors detection, decision making and actuator response of a mobile robot. This research helped to develop a mobile robot with a better performance and can complete task within the time constraint.

Forest ecotone response to climate change: sensitivity to temperature response functional forms

Energy Technology Data Exchange (ETDEWEB)

Loehle, C. [National Council for Air and Stream Improvement, Naperville, IL (United States)

2000-10-01

Past simulation studies have been in general agreement that climatic change could have adverse effects on forests, including geographic range shrinkages, conversion to grassland, and catastrophic forest decline or dieback. Some other recent studies, however, concluded that this agreement is generally based on parabolic temperature response rather than functional responses or data, and may therefore exaggerate dieback effects. This paper proposes a new model of temperature response that is based on a trade-off between cold tolerance and growth rate. In this model, the growth rate increases at first, and then levels off with increasing growing degree-days. Species from more southern regions have a higher minimum temperature and a faster maximum height growth rate. It is argued that faster growth rates of southern types lead to their competitive superiority in warmer environments and that such temperature response should produce less dieback and slower rates of change than the more common parabolic response model. Theoretical justification of this model is provided, followed by application of the model to a simulated ecotone under a warming scenario. Results of the study based on the proposed asymptotic model showed no dieback and only a gradual ecotone movement north, suggesting that ecotone shifts will, in fact, take many hundreds to thousands of years, with the result that species will not face the risk of extinction. 56 refs., 1 tab., 8 figs.

Generalizability theory and item response theory

OpenAIRE

Glas, Cornelis A.W.; Eggen, T.J.H.M.; Veldkamp, B.P.

2012-01-01

Item response theory is usually applied to items with a selected-response format, such as multiple choice items, whereas generalizability theory is usually applied to constructed-response tasks assessed by raters. However, in many situations, raters may use rating scales consisting of items with a selected-response format. This chapter presents a short overview of how item response theory and generalizability theory were integrated to model such assessments. Further, the precision of the esti...

Limited information estimation of the diffusion-based item response theory model for responses and response times.

Science.gov (United States)

Ranger, Jochen; Kuhn, Jörg-Tobias; Szardenings, Carsten

2016-05-01

Psychological tests are usually analysed with item response models. Recently, some alternative measurement models have been proposed that were derived from cognitive process models developed in experimental psychology. These models consider the responses but also the response times of the test takers. Two such models are the Q-diffusion model and the D-diffusion model. Both models can be calibrated with the diffIRT package of the R statistical environment via marginal maximum likelihood (MML) estimation. In this manuscript, an alternative approach to model calibration is proposed. The approach is based on weighted least squares estimation and parallels the standard estimation approach in structural equation modelling. Estimates are determined by minimizing the discrepancy between the observed and the implied covariance matrix. The estimator is simple to implement, consistent, and asymptotically normally distributed. Least squares estimation also provides a test of model fit by comparing the observed and implied covariance matrix. The estimator and the test of model fit are evaluated in a simulation study. Although parameter recovery is good, the estimator is less efficient than the MML estimator. © 2016 The British Psychological Society.

Can Arousal Modulate Response Inhibition?

Science.gov (United States)

Weinbach, Noam; Kalanthroff, Eyal; Avnit, Amir; Henik, Avishai

2015-01-01

The goal of the present study was to examine if and how arousal can modulate response inhibition. Two competing hypotheses can be drawn from previous literature. One holds that alerting cues that elevate arousal should result in an impulsive response and therefore impair response inhibition. The other suggests that alerting enhances processing of…

Incorporating Response Times in Item Response Theory Models of Reading Comprehension Fluency

Science.gov (United States)

Su, Shiyang

2017-01-01

With the online assessment becoming mainstream and the recording of response times becoming straightforward, the importance of response times as a measure of psychological constructs has been recognized and the literature of modeling times has been growing during the last few decades. Previous studies have tried to formulate models and theories to…

Responsibility is More than Accountability

DEFF Research Database (Denmark)

Vetterlein, Antje

2018-01-01

This paper critically assesses the notion of responsibility and argues that by adopting a broader understanding as going beyond accountability will shift our focus from regulatory to negotiated governance. Negotiated governance emphasizes the origin of rules and regulations and their contestation...... over the focus on compliance and enforcement. In order to elaborate this argument, I use the case of corporate social responsibility (CSR). The paper takes departure in the governance literature. Reviewing that scholarship, I develop a typology of responsibility to first substantiate the paper's claim...... that responsibility is more than accountability. In a second step, I derive a taxonomy of CSR practices that are loosely associated with different meanings of responsibility. The taxonomy highlights two specific problems that the literature focusing on accountability leaves unanswered, these are the moral...

Response spectrum analysis of coupled structural response to a three component seismic disturbance

International Nuclear Information System (INIS)

Boulet, J.A.M.; Carley, T.G.

1977-01-01

The work discussed herein is a comparison and evaluation of several response spectrum analysis (RSA) techniques as applied to the same structural model with seismic excitation having three spatial components. Lagrange's equations of motion for the system were written in matrix form and uncoupled with the modal matrix. Numerical integration (fourth order Runge-Kutta) of the resulting model equations produced time histories of system displacements in response to simultaneous application of three orthogonal components of ground motion, and displacement response spectra for each modal coordinate in response to each of the three ground motion components. Five different RSA techniques were used to combine the spectral displacements and the modal matrix to give approximations of maximum system displacements. These approximations were then compared with the maximum system displacements taken from the time histories. The RSA techniques used are the method of absolute sums, the square root of the sum of the squares, the double sum approach, the method of closely spaced modes, and Lin's method. The vectors of maximum system displacements as computed by the time history analysis and the five response spectrum analysis methods are presented. (Auth.)

Mechanical response of composites

NARCIS (Netherlands)

Camanho, Pedro P.; Dávila, C.G.; Pinho, Silvestre T.; Remmers, J.J.C.

2008-01-01

This book contains twelve selected papers presented at the ECCOMAS Thematic Conference ? Mechanical Response of Composites, and the papers presented by the three plenary speakers. It describes recent advances in the field of analysis models for the mechanical response of advanced composite

Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination

International Nuclear Information System (INIS)

Nogueira, Patricia; Pacheco, Mario; Lourdes Pereira, M.; Mendo, Sonia; Rotchell, Jeanette M.

2010-01-01

The responses of Dicentrarchus labrax and Liza aurata to aquatic pollution were assessed in a contaminated coastal lagoon, using both traditional and novel biomarkers combined. DNA damage, assessed by comet assay, was higher in both fish species from the contaminated sites, whereas levels of cytochrome P450 1A1 gene expression were not significantly altered. The liver histopathological analysis also revealed significant lesions in fish from contaminated sites. Alterations in ras and xpf genes were analysed and additional pollutant-responsive genes were identified. While no alterations were found in ras gene, a downregulation of xpf gene was observed in D. labrax from a contaminated site. Suppression subtractive hybridization applied to D. labrax collected at a contaminated site, revealed altered expression in genes involved in energy metabolism, immune system activity and antioxidant response. The approach and results reported herein demonstrate the utility of anchoring traditional biomarker responses alongside novel biomarker responses. - Novel molecular biomarkers of aquatic environmental contamination in fish.

Ageing and cardiorespiratory response to hypoxia.

Science.gov (United States)

Lhuissier, François J; Canouï-Poitrine, Florence; Richalet, Jean-Paul

2012-11-01

The risk of severe altitude-induced diseases is related to ventilatory and cardiac responses to hypoxia and is dependent on sex, age and exercise training status. However, it remains unclear how ageing modifies these physiological adaptations to hypoxia. We assessed the physiological responses to hypoxia with ageing through a cross-sectional 20 year study including 4675 subjects (2789 men, 1886 women; 14-85 years old) and a longitudinal study including 30 subjects explored at a mean 10.4 year interval. The influence of sex, training status and menopause was evaluated. The hypoxia-induced desaturation and the ventilatory and cardiac responses to hypoxia at rest and exercise were measured. In men, ventilatory response to hypoxia increased (P ageing. Cardiac response to hypoxia was blunted with ageing in both sexes (P ageing. These adaptive responses were less pronounced or absent in post-menopausal women (P ageing in men while cardiac response is blunted with ageing in both sexes. Training aggravates desaturation at exercise in hypoxia, improves the ventilatory response and limits the ageing-induced blunting of cardiac response to hypoxia. Training limits the negative effects of menopause in cardiorespiratory adaptations to hypoxia.

School Response to Violence: A Case Study in Developing Crisis Response Teams

Science.gov (United States)

Walsh, Ronald J.

2010-01-01

The purpose of this case study was to evaluate the perceptions of participants regarding their effectiveness in responding to defiant student violence as a crisis response team, following crisis response team training. The participants were a group of 10 volunteer PK-6 public school educators from western Wisconsin. The study took place during the…

Nesting ecology of boreal forest birds following a massive outbreak of spruce beetles

Science.gov (United States)

Matsuoka, S.M.; Handel, C.M.

2007-01-01

We studied breeding dark-eyed juncos (Junco hyemalis), yellow-rumped warblers (Dendroica coronata), and spruce-nesting birds from 1997 to 1998 among forests with different levels of spruce (Picea spp.) mortality following an outbreak of spruce beetles (Dendroctonus rufipennis) in Alaska, USA. We identified species using live and beetle-killed spruce for nest sites and monitored nests to determine how the outbreak influenced avian habitat selection and reproduction. We tested predictions that 1) nesting success of ground-nesting juncos would increase with spruce mortality due to proliferation of understory vegetation available to conceal nests from predators, 2) nesting success of canopy-nesting warblers would decrease with spruce mortality due to fewer live spruce in which to conceal nests, and 3) both species would alter nest-site selection in response to disturbance. Juncos did not benefit from changes in understory vegetation; nesting success in highly disturbed stands (46%) was comparable to that in undisturbed habitats throughout their range. In stands with low spruce mortality, nesting success of juncos was low (5%) and corresponded with high densities of red squirrels (Tamiasciurus hudsonicus). Yellow-rumped warblers nested exclusively in spruce, but success did not vary with spruce mortality. As disturbance increased, nesting warblers switched from selecting forest patches with high densities of live white spruce (Picea glauca) to patches with beetle-killed spruce. Warblers also placed nests in large-diameter live or beetle-killed spruce, depending on which was more abundant in the stand, with no differences in nesting success. Five of the 12 other species of spruce-nesting birds also used beetle-killed spruce as nest sites. Because beetle-killed spruce can remain standing for >50 years, even highly disturbed stands provide an important breeding resource for boreal forest birds. We recommend that boreal forest managers preserve uncut blocks of infested

The systemic inflammatory response syndrome.

Science.gov (United States)

Robertson, Charles M; Coopersmith, Craig M

2006-04-01

The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. This review outlines the pathophysiology of SIRS and highlights potential targets for future therapeutic intervention in patients with this complex entity.

Electromagnetic response in kinetic energy driven cuprate superconductors: Linear response approach

International Nuclear Information System (INIS)

Krzyzosiak, Mateusz; Huang, Zheyu; Feng, Shiping; Gonczarek, Ryszard

2010-01-01

Within the framework of the kinetic energy driven superconductivity, the electromagnetic response in cuprate superconductors is studied in the linear response approach. The kernel of the response function is evaluated and employed to calculate the local magnetic field profile, the magnetic field penetration depth, and the superfluid density, based on the specular reflection model for a purely transverse vector potential. It is shown that the low temperature magnetic field profile follows an exponential decay at the surface, while the magnetic field penetration depth depends linearly on temperature, except for the strong deviation from the linear characteristics at extremely low temperatures. The superfluid density is found to decrease linearly with decreasing doping concentration in the underdoped regime. The problem of gauge invariance is addressed and an approximation for the dressed current vertex, which does not violate local charge conservation is proposed and discussed.

Environmental Protection Agency Award Recipient Responsibilities

Science.gov (United States)

Itemized Award Phase information. Information about the Recipient's Responsibilities Upon Notification of the Award, The EPA Project Officer Responsibilities, and EPA Grant Specialists Responsibilities.

Collective Responsibility for Oppression

NARCIS (Netherlands)

Stahl, Titus

2017-01-01

Many contemporary forms of oppression are not primarily the result of formally organized collective action nor are they an unintended outcome of a combination of individual actions. This raises the question of collective responsibility. I argue that we can only determine who is responsible for

Corporate Social Responsibility

DEFF Research Database (Denmark)

Kampf, Constance

2007-01-01

Understanding Corporate Social Responsibility (CSR) as having explicit policies and implicit norms situated in cultural systems highlights the connections between institutional and cultural structures of nation states and business' commitment to CSR as reflected in the strategies used to communic......Understanding Corporate Social Responsibility (CSR) as having explicit policies and implicit norms situated in cultural systems highlights the connections between institutional and cultural structures of nation states and business' commitment to CSR as reflected in the strategies used...

Dose-Response Calculator for ArcGIS

Science.gov (United States)

Hanser, Steven E.; Aldridge, Cameron L.; Leu, Matthias; Nielsen, Scott E.

2011-01-01

The Dose-Response Calculator for ArcGIS is a tool that extends the Environmental Systems Research Institute (ESRI) ArcGIS 10 Desktop application to aid with the visualization of relationships between two raster GIS datasets. A dose-response curve is a line graph commonly used in medical research to examine the effects of different dosage rates of a drug or chemical (for example, carcinogen) on an outcome of interest (for example, cell mutations) (Russell and others, 1982). Dose-response curves have recently been used in ecological studies to examine the influence of an explanatory dose variable (for example, percentage of habitat cover, distance to disturbance) on a predicted response (for example, survival, probability of occurrence, abundance) (Aldridge and others, 2008). These dose curves have been created by calculating the predicted response value from a statistical model at different levels of the explanatory dose variable while holding values of other explanatory variables constant. Curves (plots) developed using the Dose-Response Calculator overcome the need to hold variables constant by using values extracted from the predicted response surface of a spatially explicit statistical model fit in a GIS, which include the variation of all explanatory variables, to visualize the univariate response to the dose variable. Application of the Dose-Response Calculator can be extended beyond the assessment of statistical model predictions and may be used to visualize the relationship between any two raster GIS datasets (see example in tool instructions). This tool generates tabular data for use in further exploration of dose-response relationships and a graph of the dose-response curve.

SOCIAL RESPONSABILITY OF INSURANCE COMPANIES

Directory of Open Access Journals (Sweden)

MĂRĂCINE MIHAELA SIMONA

2013-06-01

Full Text Available The role of corporate social responsibility has increased significantly nowadays. The studies conducted have shown that consumers are increasingly no longer interested only in buying good quality and reliable products, but they are also interested whether they were produced in a socially responsible manner. In the recent years investors have increasingly realised that investing in social responsibility regarding the social and environmental areas, greatly contributes to the growth of the internal and external image of management. This paper aims at presenting a number of interesting issues related to social responsibility manifested by the insurance companies.

Environmental reference of enterprises social responsibility

Directory of Open Access Journals (Sweden)

Dagmara K. Zuzek

2013-06-01

Full Text Available This paper presents some considerations to take over the realm of entrepreneurial responsibility for the environment. It discusses the concept of ecological trends responsibility. Evidence indicates inclusion of small and medium-sized enterprises in the area of responsibility. Business responsibilities towards the environment as a basis for making voluntary commitments are presented.

Biological significance of sperm whale responses to sonar: Comparison with anti-predator responses

NARCIS (Netherlands)

Curé, C.; Isojunno, S.; Visser, F.; Wensveen, P.J.; Sivle, L.D.; Kvadsheim, P.H.; Lam, F.A.; Miller, P.J.O.

2016-01-01

A key issue when investigating effects of anthropogenic noise on cetacean behavior is to identify the biological significance of the responses. Predator presence can be considered a natural high-level disturbance stimulus to which prey animals have evolved adaptive response strategies to reduce

Response-related potentials during semantic priming: the effect of a speeded button response task on ERPs.

Directory of Open Access Journals (Sweden)

Marijn van Vliet

Full Text Available This study examines the influence of a button response task on the event-related potential (ERP in a semantic priming experiment. Of particular interest is the N400 component. In many semantic priming studies, subjects are asked to respond to a stimulus as fast and accurately as possible by pressing a button. Response time (RT is recorded in parallel with an electroencephalogram (EEG for ERP analysis. In this case, the response occurs in the time window used for ERP analysis and response-related components may overlap with stimulus-locked ones such as the N400. This has led to a recommendation against such a design, although the issue has not been explored in depth. Since studies keep being published that disregard this issue, a more detailed examination of influence of response-related potentials on the ERP is needed. Two experiments were performed in which subjects pressed one of two buttons with their dominant hand in response to word-pairs with varying association strength (AS, indicating a personal judgement of association between the two words. In the first experiment, subjects were instructed to respond as fast and accurately as possible. In the second experiment, subjects delayed their button response to enforce a one second interval between the onset of the target word and the button response. Results show that in the first experiment a P3 component and motor-related potentials (MRPs overlap with the N400 component, which can cause a misinterpretation of the latter. In order to study the N400 component, the button response should be delayed to avoid contamination of the ERP with response-related components.

Benefits of Demand-Side Response in Providing Frequency Response Service in the Future GB Power System

Energy Technology Data Exchange (ETDEWEB)

Teng, Fei, E-mail: fei.teng09@imperial.ac.uk; Aunedi, Marko; Pudjianto, Danny; Strbac, Goran [Department of Electrical and Electronic Engineering, Imperial College London, London (United Kingdom)

2015-08-18

The demand for ancillary service is expected to increase significantly in the future Great Britain (GB) electricity system due to high penetration of wind. In particular, the need for frequency response, required to deal with sudden frequency drops following a loss of generator, will increase because of the limited inertia capability of wind plants. This paper quantifies the requirements for primary frequency response and analyses the benefits of frequency response provision from demand-side response (DSR). The results show dramatic changes in frequency response requirements driven by high penetration of wind. Case studies carried out by using an advanced stochastic generation scheduling model suggest that the provision of frequency response from DSR could greatly reduce the system operation cost, wind curtailment, and carbon emissions in the future GB system characterized by high penetration of wind. Furthermore, the results demonstrate that the benefit of DSR shows significant diurnal and seasonal variation, whereas an even more rapid (instant) delivery of frequency response from DSR could provide significant additional value. Our studies also indicate that the competing technologies to DSR, namely battery storage, and more flexible generation could potentially reduce its value by up to 35%, still leaving significant room to deploy DSR as frequency response provider.

Benefits of Demand-Side Response in Providing Frequency Response Service in the Future GB Power System

International Nuclear Information System (INIS)

Teng, Fei; Aunedi, Marko; Pudjianto, Danny; Strbac, Goran

2015-01-01

The demand for ancillary service is expected to increase significantly in the future Great Britain (GB) electricity system due to high penetration of wind. In particular, the need for frequency response, required to deal with sudden frequency drops following a loss of generator, will increase because of the limited inertia capability of wind plants. This paper quantifies the requirements for primary frequency response and analyses the benefits of frequency response provision from demand-side response (DSR). The results show dramatic changes in frequency response requirements driven by high penetration of wind. Case studies carried out by using an advanced stochastic generation scheduling model suggest that the provision of frequency response from DSR could greatly reduce the system operation cost, wind curtailment, and carbon emissions in the future GB system characterized by high penetration of wind. Furthermore, the results demonstrate that the benefit of DSR shows significant diurnal and seasonal variation, whereas an even more rapid (instant) delivery of frequency response from DSR could provide significant additional value. Our studies also indicate that the competing technologies to DSR, namely battery storage, and more flexible generation could potentially reduce its value by up to 35%, still leaving significant room to deploy DSR as frequency response provider.

The neural dynamics of stimulus and response conflict processing as a function of response complexity and task demands

Science.gov (United States)

Donohue, Sarah E.; Appelbaum, Lawrence G.; McKay, Cameron C.; Woldorff, Marty G.

2016-01-01

Both stimulus and response conflict can disrupt behavior by slowing response times and decreasing accuracy. Although several neural activations have been associated with conflict processing, it is unclear how specific any of these are to the type of stimulus conflict or the amount of response conflict. Here, we recorded electrical brain activity, while manipulating the type of stimulus conflict in the task (spatial [Flanker] versus semantic [Stroop]) and the amount of response conflict (two versus four response choices). Behaviorally, responses were slower to incongruent versus congruent stimuli across all task and response types, along with overall slowing for higher response-mapping complexity. The earliest incongruency-related neural effect was a short-duration frontally-distributed negativity at ~200 ms that was only present in the Flanker spatial-conflict task. At longer latencies, the classic fronto-central incongruency-related negativity ‘Ninc’ was observed for all conditions, which was larger and ~100 ms longer in duration with more response options. Further, the onset of the motor-related lateralized readiness potential (LRP) was earlier for the two vs. four response sets, indicating that smaller response sets enabled faster motor-response preparation. The late positive complex (LPC) was present in all conditions except the two-response Stroop task, suggesting this late conflict-related activity is not specifically related to task type or response-mapping complexity. Importantly, across tasks and conditions, the LRP onset at or before the conflict-related Ninc, indicating that motor preparation is a rapid, automatic process that interacts with the conflict-detection processes after it has begun. Together, these data highlight how different conflict-related processes operate in parallel and depend on both the cognitive demands of the task and the number of response options. PMID:26827917

Decoupling Responsible Management Education

DEFF Research Database (Denmark)

Rasche, Andreas; Gilbert, Dirk Ulrich

2015-01-01

This article examines under what conditions business schools may decouple the structural effects of their engagement in responsible management education from actual organizational practices. We argue that schools may be unable to match rising institutional pressures to publicly commit to responsi......This article examines under what conditions business schools may decouple the structural effects of their engagement in responsible management education from actual organizational practices. We argue that schools may be unable to match rising institutional pressures to publicly commit...... to responsible management education with their limited internal capacity for change. Our analysis proposes that decoupling is likely if schools (a) are exposed to resource stringency, (b) face overt or covert resistance against change processes, (c) are confronted with competing institutional pressures, and (d......) perceive institutional demands as ambiguous. We discuss two implications of this proposition. On one hand, decoupling can cause dissonant legitimacy perceptions, leading to cynicism around responsible management education within business schools. On the other hand, a temporary inconsistency between talk...

Corporate social responsibility in Islam

OpenAIRE

Elasrag, Hussein

2015-01-01

The aim of this study is to review the Islamic principles of CSR, and the definition of a structured social corporate responsibility (CSR), and based on this responsibility. And provide a practical through the international financial institutions that can implement CSR policies framework. This study provides the basis of social responsibilities that apply to those derived from divine sources of international financial institutions.

Structural-Vibration-Response Data Analysis

Science.gov (United States)

Smith, W. R.; Hechenlaible, R. N.; Perez, R. C.

1983-01-01

Computer program developed as structural-vibration-response data analysis tool for use in dynamic testing of Space Shuttle. Program provides fast and efficient time-domain least-squares curve-fitting procedure for reducing transient response data to obtain structural model frequencies and dampings from free-decay records. Procedure simultaneously identifies frequencies, damping values, and participation factors for noisy multiple-response records.

The photodiodes response in beta dosimetry

International Nuclear Information System (INIS)

Khoury, Helen; Amaral, Ademir; Hazin, Clovis; Melo, Francisco

1996-01-01

The response of the photodiodes BPY-12, BPW-34 and SFH-206 is tested for use as beta dosimeters. The results obtained show a dose-response relationships as well as less than 1% of coefficient of variation for the reproducibility of their responses. The photodiode BPY-12 has presented a better response in comparison with the others

Exploring the representational basis of response-effect compatibility: Evidence from bilingual verbal response-effect mappings.

Science.gov (United States)

Földes, Noémi; Philipp, Andrea M; Badets, Arnaud; Koch, Iring

2018-05-01

The ideomotor principle states that actions are represented by their anticipated sensory effects. This notion is often tested using the response-effect compatibility (REC) paradigm, where participants' responses are followed either by a compatible or incompatible response effect (e.g., an effect on the right side after a right-hand response is considered R-E compatible due to the spatial overlap, whereas an effect on the left side after the right-hand response is considered incompatible). Shorter reaction times are typically observed in the compatible condition compared to the incompatible condition (i.e., REC effect), suggesting that effect anticipation plays a role in action control. Previous evidence from verbal REC suggested that effect anticipation can be due to conceptual R-E overlap, but there was also phonological overlap (i.e., anticipated reading of a word preceded by the vocal response of saying that very word). To examine the representational basis of REC, in three experiments, we introduced a bilingual R-E mapping to exclude phonological R-E overlap (i.e., in the R-E compatible condition, the translation equivalent of the response word is presented as an effect word in a different language). Our findings show that the REC effect is obtained when presenting the effect word in the same language as the response (i.e., monolingual condition), but the compatibility effect was not found when the semantically same word is presented in a different language, suggesting no conceptually generalized REC in a bilingual setting. (232 words). Copyright © 2018 Elsevier B.V. All rights reserved.

Responsibility practices and unmanned military technologies.

Science.gov (United States)

Noorman, Merel

2014-09-01

The prospect of increasingly autonomous military robots has raised concerns about the obfuscation of human responsibility. This papers argues that whether or not and to what extent human actors are and will be considered to be responsible for the behavior of robotic systems is and will be the outcome of ongoing negotiations between the various human actors involved. These negotiations are about what technologies should do and mean, but they are also about how responsibility should be interpreted and how it can be best assigned or ascribed. The notion of responsibility practices, as the paper shows, provides a conceptual tool to examine these negotiations as well as the interplay between technological development and the ascription of responsibility. To illustrate the dynamics of responsibility practices the paper explores how the introduction of unmanned aerial vehicles has led to (re)negotiations about responsibility practices, focusing particularly on negotiations within the US Armed Forces.

Health, personal responsibility, and distributive justice

DEFF Research Database (Denmark)

Andersen, Martin Marchman

explains why we have justice-based reasons to reduce social inequality in health. In my second article I investigate and (partly) object to a suggestion put forward by Shlomi Segall, according to which we should exchange the notion of responsibility with a notion of Reasonable Avoidability in the luck...... responsibility is generally impossible. I argue, nonetheless, that this approach is plausible. In my fourth and final article I proceed under the assumption that responsibility is possible. I examine the relation between responsibility (for one’s own health condition) and cost-responsibility (for health care...

Response Expectancy and the Placebo Effect.

Science.gov (United States)

Kirsch, Irving

2018-01-01

In this chapter, I review basic tenets of response expectancy theory (Kirsch, 1985), beginning with the important distinction between response expectancies and stimulus expectancies. Although both can affect experience, the effects of response expectancies are stronger and more resistant to extinction than those of stimulus expectancies. Further, response expectancies are especially important to understanding placebo effects. The response expectancy framework is consistent with and has been amplified by the Bayesian model of predictive coding. Clinical implications of these phenomena are exemplified. © 2018 Elsevier Inc. All rights reserved.

A note on monotonicity of item response functions for ordered polytomous item response theory models.

Science.gov (United States)

Kang, Hyeon-Ah; Su, Ya-Hui; Chang, Hua-Hua

2018-03-08

A monotone relationship between a true score (τ) and a latent trait level (θ) has been a key assumption for many psychometric applications. The monotonicity property in dichotomous response models is evident as a result of a transformation via a test characteristic curve. Monotonicity in polytomous models, in contrast, is not immediately obvious because item response functions are determined by a set of response category curves, which are conceivably non-monotonic in θ. The purpose of the present note is to demonstrate strict monotonicity in ordered polytomous item response models. Five models that are widely used in operational assessments are considered for proof: the generalized partial credit model (Muraki, 1992, Applied Psychological Measurement, 16, 159), the nominal model (Bock, 1972, Psychometrika, 37, 29), the partial credit model (Masters, 1982, Psychometrika, 47, 147), the rating scale model (Andrich, 1978, Psychometrika, 43, 561), and the graded response model (Samejima, 1972, A general model for free-response data (Psychometric Monograph no. 18). Psychometric Society, Richmond). The study asserts that the item response functions in these models strictly increase in θ and thus there exists strict monotonicity between τ and θ under certain specified conditions. This conclusion validates the practice of customarily using τ in place of θ in applied settings and provides theoretical grounds for one-to-one transformations between the two scales. © 2018 The British Psychological Society.

Radio-adaptive response

International Nuclear Information System (INIS)

Ikushima, Takaji

1991-01-01

An adaptive response to radiation stress was found in cultured Chinese hamster V79 cells, as a suppressed induction of micronuclei (MNs) and sister chromatid exchanges (SCEs) in the cells conditioned by very low doses. The important characteristics of the novel chromosomal response, called radio-adaptive response (RAR), that have newly emerged in this study are: 1) Low doses of beta-rays from tritiated water (HTO) as well as tritiated thymidine can cause the RAR. 2) Thermal neutrons, a high LET radiation, can not act as tritium beta-rays or gamma-rays. 3) The RAR expression is suppressed by an inhibition of protein synthesis. 4) Several proteins are newly synthesized concurrently with the RAR expression after adapting doses, viewed by two-dimensional electrophoresis of cellular proteins. These results suggest that the RAR is an adaptive chromosomal DNA repair induced by very low doses of low LET radiations under restricted conditions, accompanying the inducible specific gene expression. (author)

Responses of plants to air pollution

National Research Council Canada - National Science Library

Mudd, J. Brian; Kozlowski, T. T

1975-01-01

.... KOZLOWSKI Pollution, 1975 ELROY L. RICE. Allelopathy, (Eds.). Fire and Ecosystems, 1974 (Eds.). Responses of Plants to Air Responses of Plants to Air PollutionRESPONSES OF PLANTS TO AIR POLLUTION E...

Coupling Metallic Nanostructures to Thermally Responsive Polymers Allows the Development of Intelligent Responsive Membranes

Directory of Open Access Journals (Sweden)

J. Rubén Morones-Ramírez

2014-01-01

Full Text Available Development of porous membranes capable of controlling flow or changing their permeability to specific chemical entities, in response to small changes in environmental stimuli, is an area of appealing research, since these membranes present a wide variety of applications. The synthesis of these membranes has been mainly approached through grafting of environmentally responsive polymers to the surface walls of polymeric porous membranes. This synergizes the chemical stability and mechanical strength of the polymer membrane with the fast response times of the bonded polymer chains. Therefore, different composite membranes capable of changing their effective pore size with environmental triggers have been developed. A recent interest has been the development of porous membranes responsive to light, since these can achieve rapid, remote, noninvasive, and localized flow control. This work describes the synthesis pathway to construct intelligent optothermally responsive membranes. The method followed involved the grafting of optothermally responsive polymer-metal nanoparticle nanocomposites to polycarbonate track-etched porous membranes (PCTEPMs. The nanoparticles coupled to the polymer grafts serve as the optothermal energy converters to achieve optical switching of the pores. The results of the paper show that grafting of the polymer and in situ synthesis of the metallic particles can be easily achieved. In addition, the composite membranes allow fast and reversible switching of the pores using both light and heat permitting control of fluid flow.

Ethylene response factor AtERF72 negatively regulates Arabidopsis thaliana response to iron deficiency.

Science.gov (United States)

Liu, Wei; Li, Qiwei; Wang, Yi; Wu, Ting; Yang, Yafei; Zhang, Xinzhong; Han, Zhenhai; Xu, Xuefeng

2017-09-23

Ethylene regulates the plant's response to stress caused by iron (Fe) deficiency. However, specific roles of ERF proteins in response to Fe deficiency remain poorly understood. Here, we investigated the role of ERF72 in response to iron deficiency in Arabidopsis thaliana. In this study, the levels of the ethylene response factor AtERF72 increased in leaves and roots induced under the iron deficient conditions. erf72 mutant plants showed increased growth compared to wild type (WT) when grown in iron deficient medium for 5 d. erf72 mutants had increased root H + velocity and the ferric reductase activity, and increase in the expression of the iron deficiency response genes iron-regulated transporter 1 (IRT1) and H + -ATPase (HA2) levels in iron deficient conditions. Compared to WT plants, erf72 mutants retained healthy chloroplast structure with significantly higher Fe and Mg content, and decreased chlorophyll degradation gene pheophorbide a oxygenase (PAO) and chlorophyllase (CLH1) expression when grown in iron deficient media. Yeast one-hybrid analysis showed that ERF72 could directly bind to the promoter regions of iron deficiency responses genes IRT1, HA2 and CLH1. Based on our results, we suggest that ethylene released from plants under iron deficiency stress can activate the expression of ERF72, which responds to iron deficiency in the negative regulation. Copyright © 2017 Elsevier Inc. All rights reserved.

Indicators of responsible investing

NARCIS (Netherlands)

Scholtens, Bert

Responsible investment has witnessed significant changes in the past decade. It is estimated that about one fifth of assets under management in the US and about half of all assets under management in the EU are done on the basis of one of the seven responsible investment strategies. This paper

Oil Spill Response Manual

NARCIS (Netherlands)

Marieke Zeinstra; Sandra Heins; Wierd Koops

2014-01-01

A two year programme has been carried out by the NHL University of Applied Sciences together with private companies in the field of oil and chemical spill response to finalize these manuals on oil and chemical spill response. These manuals give a good overview of all aspects of oil and chemical

Responsible Hospitality. Prevention Updates

Science.gov (United States)

Colthurst, Tom

2004-01-01

Responsible Hospitality (RH)--also called Responsible Beverage Service (RBS)--encompasses a variety of strategies for reducing risks associated with the sale and service of alcoholic beverages. RH programs have three goals: (1) to prevent illegal alcohol service to minors; (2) to reduce the likelihood of drinkers becoming intoxicated; and (3) to…

Responsible leader behavior in health sectors.

Science.gov (United States)

Longest, Beaufort

2017-02-06

Purpose The purpose of this paper is to expand attention to responsible leader behavior in the world's health sectors by explaining how this concept applies to health sectors, considering why health sector leaders should behave responsibly, reviewing how they can do so, and asserting potential impact through an applied example. Design/methodology/approach This paper is a viewpoint, reflecting conceptualizations rooted in leadership literature which are then specifically applied to health sectors. A definition of responsible leader behavior is affirmed and applied specifically in health sectors. Conceptualizations and viewpoints about practice of responsible leader behavior in health sectors and potential consequences are then discussed and asserted. Findings Leadership failures and debacles found in health, but more so in other sectors, have led leadership researchers to offer insights, many of them empirical, into the challenges of leadership especially by more clearly delineating responsible leader behavior. Practical implications Much of what has been learned in the research about responsible leader behavior offers pathways for health sector leaders to more fully practice responsible leadership. Social implications This paper asserts and provides a supporting example that greater levels of responsible leader behavior in health sectors hold potentially important societal benefits. Originality/value This paper is the first to apply emerging conceptualizations and early empirical findings about responsible leader behavior specifically to leaders in health sectors.

From Response to Responsibility: A Study of the Other and Language in the Ethical Structure of Responsibility in the Writings of Bonhoetrer and Levinas

OpenAIRE

Liu, Yinya

2010-01-01

This thesis explores the emergence of the concept of ethical responsibility in the writings of Dietrich Bonhoeffer (1906-1945) and Emmanuel Levinas (1906-1995). It argues that 'the other' and 'language' are both indispensable and correlative elements in the analysis of ethical responsibility presented by these two authors. Chapter one outlines the main theories of responsibility that have unfolded down in the history of philosophy to the twentieth century, noting the need to re...

Heart rate response to breathing

DEFF Research Database (Denmark)

Mehlsen, J; Pagh, K; Nielsen, J S

1987-01-01

Heart rate responses to stepwise and periodic changes in lung volume were studied in seven young healthy males. Stepwise inspiration and expiration both resulted in an increase in heart rate followed by a rapid decrease in heart rate. The fastest heart rate was reached in 1.6 +/- 0.5 s and in 3.......6 +/- 1.4 s in response to inspiration and expiration, respectively (P less than 0.01). The slowest heart rate was reached in 4.8 +/- 1.0 s and in 7.6 +/- 1.9 s in response to inspiration and expiration, respectively (P less than 0.01). Following this biphasic change the heart rate returned to a steady...... level. The difference between the fastest and the slowest heart rates was significantly larger in response to inspiration (21.7 +/- 7.3 beats per minute) than in response to expiration (12.0 +/- 7.3 beats per minute; P less than 0.01). Periodic changes in lung volume were performed with frequencies from...

Genetic Influences on Response to Alcohol and Response to Pharmacotherapies for Alcoholism

Science.gov (United States)

Enoch, Mary-Anne

2014-01-01

Although very many individuals drink alcohol at safe levels, a significant proportion escalates their consumption with addiction as the end result. Alcoholism is a common, moderately heritable, psychiatric disorder that is accompanied by considerable morbidity and mortality. Variation in clinical presentation suggests inter-individual variation in mechanisms of vulnerability including genetic risk factors. The development of addiction is likely to involve numerous functional genetic variants of small effects. The first part of this review will focus on genetic factors underlying inter-individual variability in response to alcohol consumption, including variants in alcohol metabolizing genes that produce an aversive response (the flushing syndrome) and variants that predict the level of subjective and physiological response to alcohol. The second part of this review will report on genetic variants that identify subgroups of alcoholics who are more likely to respond to pharmacotherapy to reduce levels of drinking or maintain abstinence. Genetic analyses of the level of response to alcohol, particularly of the functional OPRM1 A118G polymorphism and 5′ and 3′ functional polymorphisms in SLC6A4, are beginning to provide insights into the etiology of alcoholism and also genotype-stratified subgroup responses to naltrexone and SSRIs / ondansetron respectively. Because of large inter-ethnic variation in allele frequencies, the relevance of these functional polymorphisms will vary between ethnic groups. However there are relatively few published studies in this field, particularly with large sample sizes in pharmacogenetic studies, therefore it is premature to draw any conclusions at this stage. PMID:24220019

Network Culture, Performance & Corporate Responsibility

OpenAIRE

Silvio M. Brondoni

2003-01-01

The growth and sustainability of free market economies highlights the need to define rules more suited to the current condition of market globalisation and also encourages firms to adopt more transparent and accountable corporate responsibility (and corporate social responsibility, namely the relationship between the company, environment and social setting). From a managerial perspective, corporate responsibility is linked to ensure the lasting pursuit of the company mission, seeking increasi...

Personal responsibility in oral health: ethical considerations.

Science.gov (United States)

Albertsen, Andreas

2012-11-30

Personal responsibility is a powerful idea supported by many values central to West European thought. On the conceptual level personal responsibility is a complex notion. It is important to separate the concept of being responsible for a given state of affairs from the concept of holding people responsible by introducing measures that decrease their share of available resources. Introducing personal responsibility in oral health also has limitations of a more practical nature. Knowledge, social status and other diseases affect the degree to which people can be said to be responsible for their poor oral health. These factors affect people's oral health and their ability to take care of it. Both the conceptual and practical issues at stake are not reasons to abandon the idea of personal responsibility in oral health, but they do affect what the notion means and when it is reasonable to hold people responsible. They also commit people who support the idea of personal responsibility in oral health to supporting the idea of societal responsibility for mitigating the effects of factors that diminish people's responsibility and increase the available information and knowledge in the population.

The desmoplastic response

International Nuclear Information System (INIS)

Fearns, C.

1989-04-01

Desmoplasia, a process in which excessive connective tissue is deposited in a neoplasm, is discussed. To study the process, a human malignant melanoma cell line (UCT-Mel 7) was used, that was established in the laboratory, and when injected into athymic mice, it gave rise to tumours that showed a number of interesting features. The tumour induced a marked desmoplastic response and the desmoplasia was associated in UCT-Mel 7-derived tumours with an unusual phasic pattern of growth. Two possible mechanisms were identified by which UCT-Mel 7 cells could have induced the desmoplastic response. UCT-Mel 7 cells were shown to be chemotactic for mouse macrophages and human foreskin fibroblasts were stimulated, in a dose-dependent manner, to synthesize increased amounts of collagen when co-cultured with mouse peritoneal exudate cells. Tumour cells were also found to act directly. Co-culture of UCT-Mel 7 cells and fibroblasts resulted in increased collagen synthesis by the fibroblasts. DNA synthesis was not required. Dexamethasone, retinoic acid and the tumour promoter, phorbol myristate acetate, had significant primary effects on fibroblast collagen synthesis but did not modify the response to melanoma cells. Recombinant basic fibroblast growth factor did not seem to be involved in the desmoplastic response. A surprising finding was the production of a potent inhibitor of collagen synthesis by superinduced cells of the mouse macrophage cell line, P388D 1 . This inhibitor has not been fully characterised. 49 figs., 33 tabs., 362 refs

Host response to simultaneous infections with Eimeria acervulina, maxima and tenella: A cumulation of single responses

NARCIS (Netherlands)

Cornelissen, J.B.W.J.; Swinkels, W.J.C.; Boersma, W.A.; Rebel, J.M.J.

2009-01-01

It is well known that broilers may be infected by different Eimeria strains at the same time and that different species infect specific parts of the gut. Cell mediated responses play a major role in the immune response in broilers after infection with Eimeria species. The cell mediated responses

Emotional Response, Brand Recall and Response Latency to Visual Register for Food and Beverage Print Ads

Directory of Open Access Journals (Sweden)

Irma Puskarevic

2013-12-01

Full Text Available Understanding the nature of advertising principles or any other means of marketing communication that affects consume behavior has long been the subject of marketing research. The research of emotional response in relation to ad efficiency in this paper is an extension of the research previously conducted (Nedeljkovic et al., 2011. The aim of this research is to show how the ad content i.e. visual message in printed advertisements affects emotional response. Two hypotheses were postulated. First, we expected more positive response for ads with predominating iconic content. The second hypothesis sought to determine if greater response latency can be expected for ads with dominant tropological content. The method of research was SAM visual method of self-assessment. Emotional response and response latency of the participants were measured for advertisements for food and beverage products and services in order to determine how visual ad content influences emotional response of the participants, as well as the effectiveness of the advertising campaign. In an experiment the participants could rate their emotional response using the Self-assessment Manikin (SAM scale toward both types of advertisements. At the same time the response latency was measured. The results show that the main hypothesis was neither confirmed nor rejected, whereas the second hypothesis was confirmed. We conclude that the attitude towards the ad, as mediating variable, is a good indicator of advertising effectiveness.

Patterns in response to chronic terrorism threats: A construct of emotional, cognitive, and behavioral responses among Israeli citizens.

Science.gov (United States)

Cohen-Louck, Keren; Saka, Yael

2017-10-01

Israeli citizens are exposed to unpredictable and chronic terrorism threats that significantly jeopardize their personal sense of safety. The purpose of the present study is to present how Israeli discourse is structured with regard to emotional, cognitive, and behavioral responses to chronic terrorism threats and to understand the range of responses as well as map the risk and protective factors of this existential threat. Semistructured in-depth interviews were conducted with 40 Israeli adults (22 women and 18 men). Qualitative analysis revealed three patterns of responses to ongoing terrorism: emotional, cognitive, and behavioral. Emotional responses include fear, worry, sense of empathy, and detachment. Cognitive responses include situational assessment and pursuit of solutions, the use of traumatic imagining, beliefs in fate and luck, and optimism. Behavioral responses include looking for information, alertness, and habituation. The findings also revealed another response, which combines cognitive and behavioral responses. Some of the responses are innovative and unique to the threat of terrorism. Mapping the responses revealed mental health risk factors, as well as protective factors that can help structure personal and national resilience. These findings have implications on the treatment and prevention of personal and social pathologies, and how to effectively cope with terrorism threats. Copyright © 2016 John Wiley & Sons, Ltd.

The university and the responsible conduct of research: who is responsible for what?

Science.gov (United States)

Alfredo, Katherine; Hart, Hillary

2011-09-01

Research misconduct has been thoroughly discussed in the literature, but mainly in terms of definitions and prescriptions for proper conduct. Even when case studies are cited, they are generally used as a repository of "lessons learned." What has been lacking from this conversation is how the lessons of responsible conduct of research are imparted in the first place to graduate students, especially those in technical fields such as engineering. Nor has there been much conversation about who is responsible for what in training students in Responsible Conduct of Research or in allocating blame in cases of misconduct. This paper explores three seemingly disparate cases of misconduct-the 2004 plagiarism scandal at Ohio University; the famous Robert Millikan article of 1913, in which his reported data selection did not match his notebooks; and the 1990 fabrication scandal in Dr. Leroy Hood's research lab. Comparing these cases provides a way to look at the relationship between the graduate student (or trainee) and his/her advisor (a relationship that has been shown to be the most influential one for the student) as well as at possibly differential treatment for established researchers and researchers-in-training, in cases of misconduct. This paper reflects on the rights and responsibilities of research advisers and their students and offers suggestions for clarifying both those responsibilities and the particularly murky areas of research-conduct guidelines.

Radiological emergency response - a functional approach

International Nuclear Information System (INIS)

Chowdhury, P.

1998-01-01

The state of Louisiana's radiological emergency response programme is based on the federal guidance 'Criteria for Preparation and Evaluation of Radiological Emergency Response Plans and Preparedness in Support of Nuclear Power Plants' (NUREG-0654, FEMA-REP-1 Rev. 1). Over the past 14 years, the planning and implementation of response capabilities became more organized and efficient; the training programme has strengthened considerably; co-ordination with all participating agencies has assumed a more co-operative role, and as a result, a fairly well integrated response planning has evolved. Recently, a more 'functional' approach is being adopted to maximize the programme's efficiency not only for nuclear power plant emergency response, but radiological emergency response as a whole. First, several broad-based 'components' are identified; clusters of 'nodes' are generated for each component; these 'nodes' may be divided into 'sub-nodes' which will contain some 'attributes'; 'relational bonds' among the 'attributes' will exist. When executed, the process begins and continues with the 'nodes' assuming a functional and dynamic role based on the nature and characteristics of the 'attributes'. The typical response based on stand-alone elements is thus eliminated, the overlapping of functions is avoided, and a well structured and efficient organization is produced, that is essential for today's complex nature of emergency response. (author)

Plant Nucleolar Stress Response, a New Face in the NAC-Dependent Cellular Stress Responses

Directory of Open Access Journals (Sweden)

Iwai Ohbayashi

2018-01-01

Full Text Available The nucleolus is the most prominent nuclear domain, where the core processes of ribosome biogenesis occur vigorously. All these processes are finely orchestrated by many nucleolar factors to build precisely ribosome particles. In animal cells, perturbations of ribosome biogenesis, mostly accompanied by structural disorders of the nucleolus, cause a kind of cellular stress to induce cell cycle arrest, senescence, or apoptosis, which is called nucleolar stress response. The best-characterized pathway of this stress response involves p53 and MDM2 as key players. p53 is a crucial transcription factor that functions in response to not only nucleolar stress but also other cellular stresses such as DNA damage stress. These cellular stresses release p53 from the inhibition by MDM2, an E3 ubiquitin ligase targeting p53, in various ways, which leads to p53-dependent activation of a set of genes. In plants, genetic impairments of ribosome biogenesis factors or ribosome components have been shown to cause characteristic phenotypes, including a narrow and pointed leaf shape, implying a common signaling pathway connecting ribosomal perturbations and certain aspects of growth and development. Unlike animals, however, plants have neither p53 nor MDM2 family proteins. Then the question arises whether plant cells have a nucleolar stress response pathway. In recent years, it has been reported that several members of the plant-specific transcription factor family NAC play critical roles in the pathways responsive to various cellular stresses. In this mini review, we outline the plant cellular stress response pathways involving NAC transcription factors with reference to the p53-MDM2-dependent pathways of animal cells, and discuss the possible involvement of a plant-unique, NAC-mediated pathway in the nucleolar stress response in plants.

Plant Nucleolar Stress Response, a New Face in the NAC-Dependent Cellular Stress Responses.

Science.gov (United States)

Ohbayashi, Iwai; Sugiyama, Munetaka

2017-01-01

The nucleolus is the most prominent nuclear domain, where the core processes of ribosome biogenesis occur vigorously. All these processes are finely orchestrated by many nucleolar factors to build precisely ribosome particles. In animal cells, perturbations of ribosome biogenesis, mostly accompanied by structural disorders of the nucleolus, cause a kind of cellular stress to induce cell cycle arrest, senescence, or apoptosis, which is called nucleolar stress response. The best-characterized pathway of this stress response involves p53 and MDM2 as key players. p53 is a crucial transcription factor that functions in response to not only nucleolar stress but also other cellular stresses such as DNA damage stress. These cellular stresses release p53 from the inhibition by MDM2, an E3 ubiquitin ligase targeting p53, in various ways, which leads to p53-dependent activation of a set of genes. In plants, genetic impairments of ribosome biogenesis factors or ribosome components have been shown to cause characteristic phenotypes, including a narrow and pointed leaf shape, implying a common signaling pathway connecting ribosomal perturbations and certain aspects of growth and development. Unlike animals, however, plants have neither p53 nor MDM2 family proteins. Then the question arises whether plant cells have a nucleolar stress response pathway. In recent years, it has been reported that several members of the plant-specific transcription factor family NAC play critical roles in the pathways responsive to various cellular stresses. In this mini review, we outline the plant cellular stress response pathways involving NAC transcription factors with reference to the p53-MDM2-dependent pathways of animal cells, and discuss the possible involvement of a plant-unique, NAC-mediated pathway in the nucleolar stress response in plants.

Corporate social responsibility in Ukraine

OpenAIRE

Polyakova, E.

2013-01-01

In the article are considered essence of corporate social responsibility and terms necessary for realization of social activity management subjects. Hikes over are brought to realization of corporate social responsibility, meaningfulness of large and middle business is certain in becoming of social responsibility of enterprises. It is set that exactly midsize business must come forward as a main motor of economic development of Ukraine. Becoming features and modern state of corporate social r...

THE DEVELOPMENT OF LEGAL RESPONSIBILITY FOR A SOCIALLY RESPONSIBLE BEHAVIOR FOR BUSINESS OPERATORS IN ROMANIA, MEMBER STATE OF EUROPEAN UNION

OpenAIRE

Laura MURESAN

2016-01-01

Legal responsibility represents an important component of social responsibility, together with ethical responsibility, ecological responsibility, economical responsibility and philanthropic responsibility. The integration of social responsibility into the activity of business operators in the Member states of European Union is pursued at European Union level. The article analyses the opinion of the Brasov city citizens, in the framework of a marketing research performed in 2015, as regards th...

Responsibility as the Foundation of Ethics

DEFF Research Database (Denmark)

Rendtorff, Jacob Dahl

2016-01-01

notion in order to understand the ethical duty in a modern technological civilisation. We can indeed observe a moralization of the concept of responsibility going beyond a strict legal definition in terms of imputability. The paper begins by discussing the humanistic foundations of such a concept......In this paper I would like to show the importance of the concept of responsibility as the foundation of ethics in particular in the fields of politics and economics in the modern civilisation marked by globalization and technological progres. I consider the concept of responsibility as the key...... of responsibility. It treats the historical origins of responsibility and it relates this concept to the concept of accountability. On the basis of this historical determination of the concept I would like to present the definition of the concept of responsibility as fundamental ethical principle that has...

Data-Driven Optimization of Incentive-based Demand Response System with Uncertain Responses of Customers

Directory of Open Access Journals (Sweden)

Jimyung Kang

2017-10-01

Full Text Available Demand response is nowadays considered as another type of generator, beyond just a simple peak reduction mechanism. A demand response service provider (DRSP can, through its subcontracts with many energy customers, virtually generate electricity with actual load reduction. However, in this type of virtual generator, the amount of load reduction includes inevitable uncertainty, because it consists of a very large number of independent energy customers. While they may reduce energy today, they might not tomorrow. In this circumstance, a DSRP must choose a proper set of these uncertain customers to achieve the exact preferred amount of load curtailment. In this paper, the customer selection problem for a service provider that consists of uncertain responses of customers is defined and solved. The uncertainty of energy reduction is fully considered in the formulation with data-driven probability distribution modeling and stochastic programming technique. The proposed optimization method that utilizes only the observed load data provides a realistic and applicable solution to a demand response system. The performance of the proposed optimization is verified with real demand response event data in Korea, and the results show increased and stabilized performance from the service provider’s perspective.

Effective operational oil spill response planning

International Nuclear Information System (INIS)

Meyers, R.J.

1991-01-01

An operational Contingency Plan is one of the single most important aspects of effective oil spill response operations. It is a spill control game plan. A thorough contingency plan provides a set of guidelines that can be used to help direct all phases of spill response activities. More than simple a compilation of lists and rosters, the contingency plan reflects strategic and philosophical elements of spill response that help to ensure a viable response to any spill incident. Facilities and oil carrying vessels should have well maintained contingency plans with these features. This paper describes the requirement for effective oil spill response pans and the training required to exercise them

Response problems in a vacation panel study

Science.gov (United States)

Christine A. Vogt; Susan I. Stewart

2001-01-01

This paper investigates response problems encountered in a panel study of travel behavior. Though the overall response rate to the three-wave panel study was acceptable (over 60%), three types of response problems were encountered: refusal, non-response, and attrition. In a follow-up phone survey, a sample of individuals from each problem response group was questioned...

Eastern Frequency Response Study

Energy Technology Data Exchange (ETDEWEB)

Miller, N.W.; Shao, M.; Pajic, S.; D' Aquila, R.

2013-05-01

This study was specifically designed to investigate the frequency response of the Eastern Interconnection that results from large loss-of-generation events of the type targeted by the North American Electric Reliability Corp. Standard BAL-003 Frequency Response and Frequency Bias Setting (NERC 2012a), under possible future system conditions with high levels of wind generation.

Improv Chat: Second Response Generation for Chatbot

OpenAIRE

Wei, Furu

2018-01-01

Existing research on response generation for chatbot focuses on \\textbf{First Response Generation} which aims to teach the chatbot to say the first response (e.g. a sentence) appropriate to the conversation context (e.g. the user's query). In this paper, we introduce a new task \\textbf{Second Response Generation}, termed as Improv chat, which aims to teach the chatbot to say the second response after saying the first response with respect the conversation context, so as to lighten the burden ...

Global business, global responsibilities: Corporate social responsibility orientations within a multinational bank

OpenAIRE

van den Heuvel, G.G.A.; Soeters, J.M.M.L.; Goessling, T.

2014-01-01

This study examines the effects of culture, gender, and function on orientation toward corporate social responsibility (CSR) among 416 employees of an international financial service organization. The main objective of the study is to investigate the variation of corporate social responsibility orientation (CSRO) across national cultures. The authors draw on a theory of cultural value orientations to identify three culturally distinct transnational clusters: West Europe, the English speaking ...

The One Plan Project: A cooperative effort of the National Response Team and the Region 6 Regional Response Team to simplify facility emergency response planning

International Nuclear Information System (INIS)

Staves, J.; McCormick, K.

1997-01-01

The National Response Team (NRT) in coordination with the Region 6 Response Team (RRT) have developed a facility contingency plan format which would integrate all existing regulatory requirements for contingency planning. This format was developed by a multi-agency team, chaired by the USEPA Region 6, in conjunction with various industry, labor, and public interest groups. The impetus for this project came through the USEPA Office of Chemical Emergency Preparedness and Prevention (CEPPO). The current national oil and hazardous material emergency preparedness and response system is an amalgam of federal, state, local, and industrial programs which are often poorly coordinated. In a cooperative effort with the NRT, the CEPPO conducted a Presidential Review of federal agency authorities and coordination responsibilities regarding release prevention, mitigation, and response. Review recommendations led to a Pilot Project in USEPA Region 6. The Region 6 Pilot Project targeted end users in the intensely industrialized Houston Ship Channel (HSC) area, which is comprised of petroleum and petrochemical companies

Variability in response to albuminuria-lowering drugs

DEFF Research Database (Denmark)

Petrykiv, Sergei I; de Zeeuw, Dick; Persson, Frederik

2017-01-01

AIMS: Albuminuria-lowering drugs have shown different effect size in different individuals. Since urine albumin levels are known to vary considerably from day-to-day, we questioned whether the between-individual variability in albuminuria response after therapy initiation reflects a random...... variability or a true response variation to treatment. In addition, we questioned whether the response variability is drug dependent. METHODS: To determine whether the response to treatment is random or a true drug response, we correlated in six clinical trials the change in albuminuria during placebo...... or active treatment (on-treatment) with the change in albuminuria during wash-out (off-treatment). If these responses correlate during active treatment, it suggests that at least part of the response variability can be attributed to drug response variability. We tested this for enalapril, losartan...

Benefits of Demand Side Response in Providing Frequency Response Service in the Future GB Power System

Directory of Open Access Journals (Sweden)

Fei eTeng

2015-08-01

Full Text Available The demand for ancillary service is expected to increase significantly in the future GB electricity system due to high penetration of wind. In particular, the need for frequency response, required to deal with sudden frequency drops following a loss of generator, will increase because of the limited inertia capability of wind plants. This paper quantifies the requirements for primary frequency response and analyses the benefits of frequency response provision from DSR. The results show dramatic changes in frequency response requirements driven by high penetration of wind. Case studies carried out by using an advanced stochastic generation scheduling model suggest that the provision of frequency response from DSR could greatly reduce the system operation cost, wind curtailment and carbon emissions in the future GB system characterised by high penetration of wind. Furthermore, the results demonstrate that the benefit of DSR shows significant diurnal and seasonal variation, whereas an even more rapid (instant delivery of frequency response from DSR could provide significant additional value. Our studies also indicate that the competing technologies to DSR, namely battery storage and more flexible generation could potentially reduce its value by up to 35%, still leaving significant room to deploy DSR as frequency response provider.

The Ethical Challenges of Socially Responsible Science.

Science.gov (United States)

Resnik, David B; Elliott, Kevin C

2016-01-01

Social responsibility is an essential part of the responsible conduct of research that presents difficult ethical questions for scientists. Recognizing one's social responsibilities as a scientist is an important first step toward exercising social responsibility, but it is only the beginning, since scientists may confront difficult value questions when deciding how to act responsibly. Ethical dilemmas related to socially responsible science fall into at least three basic categories: 1) dilemmas related to problem selection, 2) dilemmas related to publication and data sharing, and 3) dilemmas related to engaging society. In responding to these dilemmas, scientists must decide how to balance their social responsibilities against other professional commitments and how to avoid compromising their objectivity. In this article, we will examine the philosophical and ethical basis of social responsibility in science, discuss some of the ethical dilemmas related to exercising social responsibility, and make five recommendations to help scientists deal with these issues.

Immediate response to cigarette smoke

Energy Technology Data Exchange (ETDEWEB)

Rees, P.J.; Chowienczyk, P.J.; Clark, T.J.

1982-06-01

Using an automated method of calculating airways resistance in the body plethysmograph, we have investigated changes occurring immediately after inhalation of cigarette smoke. Decreases in specific conductance occurred by the time of the first measurement seven or eight seconds after exposure to single inhalations of cigarette smoke in 12 smokers and 12 non-smokers. Less than half of the initial change was present 40 seconds after the inhalation. Initial responses were greater in the non-smokers. Responses recurred with repeated inhalations in smokers and non-smokers. Prior administration of salbutamol and ipratropium bromide significantly inhibited the response and this inhibition appeared to be greater in non-smokers. Sodium cromoglycate inhaled as a dry powder had no effect on the response.

Toward a theory of responsible investing : On the economic foundations of corporate social responsibility

NARCIS (Netherlands)

Dam, Lammertjan; Scholtens, Lambertus

Studies that link corporate social and financial performance usually find a positive association between the two. However, the literature does not establish a significant impact of socially responsible investing on stock market returns. We develop a coherent economic framework of responsible

Property Rights, Restrictions and Responsibilities

DEFF Research Database (Denmark)

Enemark, Stig

more to a social, ethical commitment or attitude to environmental sustainability and good husbandry. This paper provides an overall understanding of the concept of land administration systems for dealing with rights, restrictions and responsibilities in future spatially enabled government. Finally......Land Administration Systems are the basis for conceptualizing rights, restrictions and responsibilities related to people, policies and places. Property rights are normally concerned with ownership and tenure whereas restrictions usually control use and activities on land. Responsibilities relate...

Measuring student responsibility in Physical Education ...

African Journals Online (AJOL)

The Contextual Self-Responsibility Questionnaire (CSRQ) and Personal and Social Responsibility Questionnaire (PSRQ) were developed to meausre student responsibility within the field of physical education. In the present study, the factor structure of the CSRQ and PSRQ was examined. Unlike previous structure ...

5 CFR 410.303 - Employee responsibilities.

Science.gov (United States)

2010-01-01

... Establishing and Implementing Training Programs § 410.303 Employee responsibilities. Employees are responsible... training needed to improve individual and organizational performance and identify methods to meet those... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Employee responsibilities. 410.303...

SSI response of a typical shear wall structure. Appendix B. In-structure response spectra comparisons. Volume 2

International Nuclear Information System (INIS)

Johnson, J.J.; Schewe, E.C.; Maslenikov, O.R.

1984-04-01

The objectives of this study were two-fold: (1) develop building response calibration factors, i.e., factors which relate best estimate or median level response to responses calculated by selected design procedures. Soil-structure interaction was the phenomenon of interest because significant simplifications are frequently introduced in its treatment; and (2) the second objective can be viewed in the context of a question: what effect does placing an identical structure on different sites and with different foundation conditions have on structure response. The structure selected for this study is a part of the Zion AFT complex. Only the auxiliary, fuel-handling, and diesel generator buildings were studied. This structure is a connected group of shear-wall buildings constructed of reinforced concrete, typical of nuclear power plant structures. The bases of comparison for this study were structure responses: peak in-structure accelerations (27 components), and peak wall forces and moments (111 components). In-structure response spectra were also considered. This appendix contains in-structure response spectra comparisons in detail

Model for Managing Corporate Social Responsibility

Directory of Open Access Journals (Sweden)

Tamara Vlastelica Bakić

2015-05-01

Full Text Available As a crossfuncional process in the organization, effective management of corporate social responsibility requires a definition of strategies, programs and an action plan that structures this process from its initiation to the measurement of end effects. Academic literature on the topic of corporate social responsibility is mainly focused on the exploration of the business case for the concept, i.e., the determination of effects of social responsibility on individual aspects of the business. Scientific research so far has shown not to have been committed to formalizing management concept in this domain to a satisfactory extent; it is for this reason that this paper attempts to present one model for managing corporate social responsibility. The model represents a contribution to the theory and business practice of corporate social responsibility, as it offers a strategic framework for systematic planning, implementation and evaluation of socially responsible activities and programs.

Response spectra in alluvial soils

International Nuclear Information System (INIS)

Chandrasekharan, A.R.; Paul, D.K.

1975-01-01

For aseismic design of structures, the ground motion data is assumed either in the form of ground acceleration as a function of time or indirectly in the form of response spectra. Though the response spectra approach has limitations like not being applicable for nonlinear problems, it is usually used for structures like nuclear power plants. Fifty accelerograms recorded at alluvial sites have been processed. Since different empirical formulas relating acceleration with magnitude and distance give a wide scatter of values, peak ground acceleration alone cannot be the parameter as is assumed by a number of authors. The spectra corresponding to 5% damping have been normalised with respect to three parameters, namely, peak ground acceleration, peak ground velocity and a nondimensional quantity ad/v 2 . Envelopee of maxima and minima as well as average response spectra has been obtained. A comparison with the USAEC spectra has been made. A relation between ground acceleration, ground velocity and ad/v 2 has been obtained which would nearly give the same magnification of the response. A design response spectra for alluvial soils has been recommended. (author)

Response Cries.

Science.gov (United States)

Goffman, Erving

1978-01-01

Considers utterances that appear to violate the interdependence assumed by the interactionist view, entering the stream of behavior at peculiar and unnatural places, producing communicative effects but no dialogue. Self-talk, imprecations, and response cries are discussed. (EJS)

Immunological Responses to Total Hip Arthroplasty.

Science.gov (United States)

Man, Kenny; Jiang, Lin-Hua; Foster, Richard; Yang, Xuebin B

2017-08-01

The use of total hip arthroplasties (THA) has been continuously rising to meet the demands of the increasingly ageing population. To date, this procedure has been highly successful in relieving pain and restoring the functionality of patients' joints, and has significantly improved their quality of life. However, these implants are expected to eventually fail after 15-25 years in situ due to slow progressive inflammatory responses at the bone-implant interface. Such inflammatory responses are primarily mediated by immune cells such as macrophages, triggered by implant wear particles. As a result, aseptic loosening is the main cause for revision surgery over the mid and long-term and is responsible for more than 70% of hip revisions. In some patients with a metal-on-metal (MoM) implant, metallic implant wear particles can give rise to metal sensitivity. Therefore, engineering biomaterials, which are immunologically inert or support the healing process, require an in-depth understanding of the host inflammatory and wound-healing response to implanted materials. This review discusses the immunological response initiated by biomaterials extensively used in THA, ultra-high-molecular-weight polyethylene (UHMWPE), cobalt chromium (CoCr), and alumina ceramics. The biological responses of these biomaterials in bulk and particulate forms are also discussed. In conclusion, the immunological responses to bulk and particulate biomaterials vary greatly depending on the implant material types, the size of particulate and its volume, and where the response to bulk forms of differing biomaterials are relatively acute and similar, while wear particles can initiate a variety of responses such as osteolysis, metal sensitivity, and so on.

The Social Responsibility Performance Outcomes Model: Building Socially Responsible Companies through Performance Improvement Outcomes.

Science.gov (United States)

Hatcher, Tim

2000-01-01

Considers the role of performance improvement professionals and human resources development professionals in helping organizations realize the ethical and financial power of corporate social responsibility. Explains the social responsibility performance outcomes model, which incorporates the concepts of societal needs and outcomes. (LRW)

Responsive Space Program Brief

Energy Technology Data Exchange (ETDEWEB)

Dors, Eric E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2014-03-11

The goal of the Responsive Space program is to make significant, integrated science and technology contributions to the end-to-end missions of the U.S. Government that protect against global emerging and nuclear threats, from the earliest adversary planning through resilient event response report describes the LANL space program, mission, and other activities. The report describes some of their activities.

Corporate social responsibility and financial markets

NARCIS (Netherlands)

Dam, Lammertjan

2008-01-01

This thesis examines the economics of corporate social responsibility, with an emphasis on the role of financial markets and institutions. Questions that are raised are: What does corporate social responsibility mean in an economic context? What is the impact of corporate social responsibility on

21 CFR 820.20 - Management responsibility.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Management responsibility. 820.20 Section 820.20...) MEDICAL DEVICES QUALITY SYSTEM REGULATION Quality System Requirements § 820.20 Management responsibility... the quality system to management with executive responsibility for review. (c) Management review...

12 CFR 7.2010 - Directors' responsibilities.

Science.gov (United States)

2010-01-01

... refer to OCC published guidance for additional information regarding responsibilities of directors. ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Directors' responsibilities. 7.2010 Section 7... OPERATIONS Corporate Practices § 7.2010 Directors' responsibilities. The business and affairs of the bank...

Generalizability theory and item response theory

NARCIS (Netherlands)

Glas, Cornelis A.W.; Eggen, T.J.H.M.; Veldkamp, B.P.

2012-01-01

Item response theory is usually applied to items with a selected-response format, such as multiple choice items, whereas generalizability theory is usually applied to constructed-response tasks assessed by raters. However, in many situations, raters may use rating scales consisting of items with a

Placebo-like analgesia via response imagery

NARCIS (Netherlands)

Peerdeman, K.J.; Laarhoven, A.I.M. van; Bartels, D.J.P.; Peters, M.L.; Evers, A.W.M.

2017-01-01

BACKGROUND: Placebo effects on pain are reliably observed in the literature. A core mechanism of these effects is response expectancies. Response expectancies can be formed by instructions, prior experiences and observation of others. Whether mental imagery of a response can also induce placebo-like

Conceptualising environmental responsibility

International Nuclear Information System (INIS)

Lenzen, Manfred; Murray, Joy

2010-01-01

Downstream responsibility is rarely addressed in the academic literature and in corporate sustainability reporting. We conceptualise downstream responsibility for the example of carbon emissions, by establishing a terminology as well as a framework for quantifying downstream carbon footprints. By extracting emissions-intensive sales chains for a number of Australian industry sectors, and comparing these to emissions-intensive supply chains, we demonstrated the ability of input-output analysis to quantify emissions responsibility in both directions. We extend the definition of downstream responsibility beyond the product use and disposal phases, to include what we call 'enabled' emissions. This term implies that whatever is sold downstream enables our customers to operate and emit, irrespective of whether it is our product that is combusted, or that directly combusts fuels, or not. Our structural path analyses and threshold-capture relationships reveal stark differences between industries with regard to the data collection efforts necessary to achieve a reasonably complete footprint assessment. Industries appear to have their own specific carbon footprint profiles, and one cannot design generic relevance tests that tell which data to collect. Moreover we conclude that current completeness standards in carbon reporting cannot be satisfied using relevance thresholds. Input-output analysis and structural path analysis are excellent tools that can help companies undertake screening exercises, which in turn help prioritising and streamlining the collection of data needed to establish a corporate downstream carbon footprint. Compared to conventional manual approaches, hybrid life-cycle assessments assisted by input-output analysis and structural path analysis achieve more complete results, with substantially less staff, money and time. (author)

"Responsibility in Mobility": International Students and Social Responsibility

Science.gov (United States)

Tran, Ly Thi; Vu, Thao Thi Phuong

2017-01-01

Enhancing the educational experience and social connectedness for international students is the responsibility of different involved parties among whom international students themselves and host institutions play a key role. However, the question of how the condition of cross-border mobility has shaped and re-shaped international students'…

Responsible Leadership Research: A Bibliometric Review

Directory of Open Access Journals (Sweden)

Tânia Marques

2018-03-01

Full Text Available Political, religious, sports and business leaders across the world have been under scrutiny regarding allegedly unethical behaviors. The current study analyzes the use of responsible leadership in management research. Using a sample of 64 articles published in SSCI-indexed journals over 10 years (2006-2016, we carried out a bibliometric analysis to understand the intellectual structure of the responsible leadership literature. The results of authorship, citation and co-citation, and factor analyses reveal the most prolific authors and the most notable journals writing and publishing on responsible leadership. The most cited works are theoretical, using Western frameworks and cultures, and focus on the concept of responsible leadership; only a few empirical/case study articles appear. Also, the most prevalent links are between theoretical works and highlight the conceptualization, understanding, and roles and parameters of responsible leaders. Six distinct factors emerge, denoting the groups of studies devoted to the evolution of leadership, transformational leadership, stakeholder theory and leadership, conceptualization and understanding of the topic, and roles of responsible leaders. These various research topics show the central tenets of responsible leadership, as well as the existing gaps in the existent literature.

G2 Checkpoint Responses in Arabidopsis

Energy Technology Data Exchange (ETDEWEB)

Britt, Anne [Univ. of California, Davis, CA (United States)

2013-03-18

This project focused on the mechanism and biological significance of the G2 arrest response to replication stress in plants. We employed both forward and reverse genetic approaches to identify genes required for this response. A total of 3 different postdocs, 5 undergraduates, and 2 graduate students participated in the project. We identified several genes required for damage response in plants, including homologs of genes previously identified in animals (ATM and ATR), novel, a plant-specific genes (SOG1) and a gene known in animals but previously thought to be missing from the Arabidopsis genome (ATRIP). We characterized the transcriptome of gamma-irradiated plants, and found that plants, unlike animals, express a robust transcriptional response to damage, involving genes that regulate the cell cycle and DNA metabolism. This response requires both ATM and the transcription factor SOG1. We found that both ATM and ATR play a role in meiosis in plants. We also found that plants have a cell-type-specific programmed cell death response to ionizing radiation and UV light, and that this response requires ATR, ATM, and SOG1. These results were published in a series of 5 papers.

Transport accident emergency response plan

International Nuclear Information System (INIS)

Vallette-Fontaine, M.; Frantz, P.

1998-01-01

To comply with the IAEA recommendations for the implementation of an Emergency Response Plan as described in Safety Series 87, Transnucleaire, a company deeply involved in the road and rail transports of the fuel cycle, masters means of Emergency Response in the event of a transport accident. This paper aims at analyzing the solutions adopted for the implementation of an Emergency Response Plan and the development of a technical support and adapted means for the recovery of heavy packagings. (authors)

32 CFR 1656.7 - Employer responsibilities.

Science.gov (United States)

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Employer responsibilities. 1656.7 Section 1656.7... SERVICE § 1656.7 Employer responsibilities. Employers participating in the Alternative Service Program are responsible for: (a) Complying with the employment agreement with Selective Service; (b) Providing a clear...

15 CFR 14.41 - Recipient responsibilities.

Science.gov (United States)

2010-01-01

... violation of statute are to be referred to such Federal, State or local authority as may have proper... COMMERCIAL ORGANIZATIONS Post-Award Requirements Procurement Standards § 14.41 Recipient responsibilities... responsibilities arising under its contract(s). The recipient is the responsible authority, without recourse to the...

Neutrophil Responses to Sterile Implant Materials.

Directory of Open Access Journals (Sweden)

Siddharth Jhunjhunwala

Full Text Available In vivo implantation of sterile materials and devices results in a foreign body immune response leading to fibrosis of implanted material. Neutrophils, one of the first immune cells to be recruited to implantation sites, have been suggested to contribute to the establishment of the inflammatory microenvironment that initiates the fibrotic response. However, the precise numbers and roles of neutrophils in response to implanted devices remains unclear. Using a mouse model of peritoneal microcapsule implantation, we show 30-500 fold increased neutrophil presence in the peritoneal exudates in response to implants. We demonstrate that these neutrophils secrete increased amounts of a variety of inflammatory cytokines and chemokines. Further, we observe that they participate in the foreign body response through the formation of neutrophil extracellular traps (NETs on implant surfaces. Our results provide new insight into neutrophil function during a foreign body response to peritoneal implants which has implications for the development of biologically compatible medical devices.

Can biomass responses to warming at plant to ecosystem levels be predicted by leaf-level responses?

Science.gov (United States)

Xia, J.; Shao, J.; Zhou, X.; Yan, W.; Lu, M.

2015-12-01

Global warming has the profound impacts on terrestrial C processes from leaf to ecosystem scales, potentially feeding back to climate dynamics. Although numerous studies had investigated the effects of warming on C processes from leaf to plant and ecosystem levels, how leaf-level responses to warming scale up to biomass responses at plant, population, and community levels are largely unknown. In this study, we compiled a dataset from 468 papers at 300 experimental sites and synthesized the warming effects on leaf-level parameters, and plant, population and ecosystem biomass. Our results showed that responses of plant biomass to warming mainly resulted from the changed leaf area rather than the altered photosynthetic capacity. The response of ecosystem biomass to warming was weaker than those of leaf area and plant biomass. However, the scaling functions from responses of leaf area to plant biomass to warming were different in diverse forest types, but functions were similar in non-forested biomes. In addition, it is challenging to scale the biomass responses from plant up to ecosystem. These results indicated that leaf area might be the appropriate index for plant biomass response to warming, and the interspecific competition might hamper the scaling of the warming effects on plant and ecosystem levels, suggesting that the acclimation capacity of plant community should be incorporated into land surface models to improve the prediction of climate-C cycle feedback.

Using module analysis for multiple choice responses

DEFF Research Database (Denmark)

Brewe, Eric; Bruun, Jesper; Bearden, Ian

2016-01-01

We describe a methodology for carrying out a network analysis of Force Concept Inventory (FCI) responses that aims to identify communities of incorrect responses. This method first treats FCI responses as a bipartite, student X response, network. We then use Locally Adaptive Network Sparsificatio...

Response: Critical Realism--Response to Longhofer and Floersch

Science.gov (United States)

Briar-Lawson, Katharine

2012-01-01

This article addresses key challenges posed by critical realism, proposed by Longhofer and Floersch, as a philosophical underpinning for a science of social work. As a response to Longhofer and Floersch, it is argued that critical realism may be instructive in debates about structural conditions that dictate more inclusive interventions and…

THE DEVELOPMENT OF LEGAL RESPONSIBILITY FOR A SOCIALLY RESPONSIBLE BEHAVIOR FOR BUSINESS OPERATORS IN ROMANIA, MEMBER STATE OF EUROPEAN UNION

Directory of Open Access Journals (Sweden)

Laura MURESAN

2016-03-01

Full Text Available Legal responsibility represents an important component of social responsibility, together with ethical responsibility, ecological responsibility, economical responsibility and philanthropic responsibility. The integration of social responsibility into the activity of business operators in the Member states of European Union is pursued at European Union level. The article analyses the opinion of the Brasov city citizens, in the framework of a marketing research performed in 2015, as regards the possibility that legal instruments should influence a socially responsible behavior for public or private business operators. The aspects analysed for business operators in Romania can represent a model for other European Union states as well.

19 CFR 210.13 - The response.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false The response. 210.13 Section 210.13 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Pleadings § 210.13 The response. (a) Time for response. Except as provided in...

Multisensory integration produces an initial response enhancement

Directory of Open Access Journals (Sweden)

Benjamin A Rowland

2007-11-01

Full Text Available The brain has evolved the ability to integrate information across the senses in order to improve the detection and disambiguation of biologically significant events. This multisensory synthesis of information leads to faster (and more accurate behavioral responses, yet the underlying neural mechanisms by which these responses are speeded are as yet unclear. The aim of these experiments was to evaluate the temporal properties of multisensory enhancement in the physiological responses of neuron in the superior colliculus (SC. Of specific interest was the temporal evolution of their responses to individual modality-specific stimuli as well as to cross-modal combinations of these stimuli. The results demonstrate that cross-modal stimuli typically elicit faster, more robust, and more reliable physiological responses than do their modality-specific component stimuli. Response measures sensitive to the time domain showed that these multisensory responses were enhanced from their very onset, and that the acceleration of the enhancement was greatest within the first 40 ms (or 50% of the response. The latter half of the multisensory response was typically only as robust and informative as predicted by a linear combination of the unisensory component responses. These results may reveal some of the key physiological changes underlying many of the SC-mediated behavioral benefits of multisensory integration.

Emergency response workers workshop

International Nuclear Information System (INIS)

Agapeev, S.A.; Glukhikh, E.N.; Tyurin, R.L.

2012-01-01

A training workshop entitled Current issues and potential improvements in Rosatom Corporation emergency prevention and response system was held in May-June, 2012. The workshop combined theoretical training with full-scale practical exercise that demonstrated the existing innovative capabilities for radiation reconnaissance, diving equipment and robotics, aircraft, emergency response and rescue hardware and machinery. This paper describes the activities carried out during the workshop [ru

National Response Framework: Annexes

Science.gov (United States)

2008-01-01

response Environmental short- and long-term cleanup ESF #11 – Agriculture and Natural Resources Nutrition assistance Animal and plant disease and pest ...continental United States, the Virgin Islands and Puerto Rico, and other U.S. territories and possession other than Alaska and U.S. territories in the...on the Pacific, Atlantic , and Gulf coasts, to provide response capabilities, technical advice, documentation and support assistance, communications

Practical aids for freshwater spill response

International Nuclear Information System (INIS)

Steen, A.E.; Walker, A.H.

1993-01-01

The current research program at API is focused on the environmental and human health effects from oil spills in freshwater habitats. Components of the program include lessons learned from spill response, development of decision-making protocols for the use of chemicals during initial response operations, preparation of a manual for spill response and contingency planning, and a review of the literature on environmental and human health effects from inland spills. API has reviewed past inland spill responses to identify lessons learned. A survey questionnaire has been developed to collect information from freshwater spill responders on their successes and difficulties in response operations. The questionnaire is tailored to focus on the impact to the operations from the absence of technical/scientific data on environmental effects or operation effectiveness/efficiency as well as to identify situations in which the use of particular response or cleanup options is likely to be effective. The questionnaires will be available at the Conference. Published case studies also will be examined for lessons-learned information. The results will be used to identify and prioritize API research needs in freshwater spill response. General concerns about the effectiveness of the toxicity associated with chemicals in spill response has prevented their use in fresh water. API has begun a detailed survey and interview process with state and federal regulatory personnel to identify their concerns and decision criteria to evaluate the use of chemicals in initial spill response. Ten classes of chemicals were identified for consideration: dispersants, shoreline cleaners, shoreline protection agents, herding agents, solidifiers, demulsifiers, emulsion inhibitors, foaming agents, oxidizing agents, and burning agents

Impaired Memory Retrieval Correlates with Individual Differences in Cortisol Response but Not Autonomic Response

Science.gov (United States)

Tranel, Daniel; Adolphs, Ralph; Buchanan, Tony W.

2006-01-01

Stress can enhance or impair memory performance. Both cortisol release and sympathetic nervous system responses have been implicated in these differential effects. Here we investigated how memory retrieval might be affected by stress-induced cortisol release, independently of sympathetic nervous system stress responses. Thirty-two healthy…

Oligodendroglial response to ionizing radiation: Dose and dose-rate response

International Nuclear Information System (INIS)

Levy, R.P.

1991-12-01

An in vitro system using neuroglia from neonatal rat brain was developed to examine the morphologic, immunocytochemical and biochemical response of oligodendroglia to ionizing radiation. Following acute γ-irradiation at day-in-culture (DIC) 8, oligodendrocyte counts at DIC 14 were 55% to 65% of control values after 2 Gy, and 29% to 36% after 5 Gy. Counts increased to near-normal levels at DIC 21 in the 2 Gy group and to 75% of normal in the 5 Gy group. Myelin basic protein levels (MBP) at DIC 14 were 60% of control values after 2 Gy, and 40% after 5 Gy. At DIC 21, MBP after 2 Gy was 45% greater than that observed at DIC 14, but MBP, as a fraction of age-matched control values, dropped from 60% to 50%. Following 5 Gy, absolute MBP changed little between DIC 14 and DIC 21, but decreased from 40% to 25% of control cultures. The response to split-dose irradiation indicated that nearly all sublethal damage in the oligodendrocyte population (and its precursors) was repaired within 3 h to 4 h. A new compartmental cell model for radiation response in vitro of the oligodendrocyte population is proposed and examined in relation to the potential reaction to radiation injury in the brain

Some considerations regarding the legal responsibility and the social responsibility

Directory of Open Access Journals (Sweden)

Diana Anca ARTENE

2014-12-01

Full Text Available The judicial responsibility is acknowledged in the judicial doctrine2, as being ‘the starting point’ of the entire social responsibility, position that continues to have from ancient times until today, thus providing an expression of Law on its most concerted form, which reflect the stage of evolution of the entire social life. Expressing forms and realities of social life, both values and norms are ideal standards of conduct, perceived as individual requirements by each member of society3. The human action enforces the compliance of certain rules and its subordination of certain goals and interests, according to a system of principles and criteria; this is because the individual lead his existence in a relational system with others, a system characterized by extensive interactions and interdependencies. In any society may appear different types of conduct, whose broad includes those conformist, innovative, as well as those non-conformists, escapist or deviant. As full integration of the individual in society, legal norms are not an exclusive element; these are the foundation of a set of rules for the most various types. The institution of social responsibility arises precisely in this way, representing a higher level of integration of the individual in the society.

Oligodendroglial response to ionizing radiation: Dose and dose-rate response

Energy Technology Data Exchange (ETDEWEB)

Levy, Richard P. [Univ. of California, Berkeley, CA (United States)

1991-12-01

An in vitro system using neuroglia from neonatal rat brain was developed to examine the morphologic, immunocytochemical and biochemical response of oligodendroglia to ionizing radiation. Following acute γ-irradiation at day-in-culture (DIC) 8, oligodendrocyte counts at DIC 14 were 55% to 65% of control values after 2 Gy, and 29% to 36% after 5 Gy. Counts increased to near-normal levels at DIC 21 in the 2 Gy group and to 75% of normal in the 5 Gy group. Myelin basic protein levels (MBP) at DIC 14 were 60% of control values after 2 Gy, and 40% after 5 Gy. At DIC 21, MBP after 2 Gy was 45% greater than that observed at DIC 14, but MBP, as a fraction of age-matched control values, dropped from 60% to 50%. Following 5 Gy, absolute MBP changed little between DIC 14 and DIC 21, but decreased from 40% to 25% of control cultures. The response to split-dose irradiation indicated that nearly all sublethal damage in the oligodendrocyte population (and its precursors) was repaired within 3 h to 4 h. A new compartmental cell model for radiation response in vitro of the oligodendrocyte population is proposed and examined in relation to the potential reaction to radiation injury in the brain.

Oligodendroglial response to ionizing radiation: Dose and dose-rate response

Energy Technology Data Exchange (ETDEWEB)

Levy, R.P.

1991-12-01

An in vitro system using neuroglia from neonatal rat brain was developed to examine the morphologic, immunocytochemical and biochemical response of oligodendroglia to ionizing radiation. Following acute {gamma}-irradiation at day-in-culture (DIC) 8, oligodendrocyte counts at DIC 14 were 55% to 65% of control values after 2 Gy, and 29% to 36% after 5 Gy. Counts increased to near-normal levels at DIC 21 in the 2 Gy group and to 75% of normal in the 5 Gy group. Myelin basic protein levels (MBP) at DIC 14 were 60% of control values after 2 Gy, and 40% after 5 Gy. At DIC 21, MBP after 2 Gy was 45% greater than that observed at DIC 14, but MBP, as a fraction of age-matched control values, dropped from 60% to 50%. Following 5 Gy, absolute MBP changed little between DIC 14 and DIC 21, but decreased from 40% to 25% of control cultures. The response to split-dose irradiation indicated that nearly all sublethal damage in the oligodendrocyte population (and its precursors) was repaired within 3 h to 4 h. A new compartmental cell model for radiation response in vitro of the oligodendrocyte population is proposed and examined in relation to the potential reaction to radiation injury in the brain.

Emergency planning and response - role nad responsibilities of the regulatory body

International Nuclear Information System (INIS)

Nizamska, M.

1999-01-01

The development of a emergency plan and organisation of adequate emergency preparedness in case of radiological accident in NPP cannot be effective without the appropriate preparatory work. In most countries, also in Republic of Bulgaria, several organisations are identified to have a potential role to play in a radiological emergency. For these reason is very important to have a national organisation, with a mandate to organise, inspect and co-ordinate the possibility of ministries and institution to react in case of radiological emergency, i.e. to quarantine the possibility for implementation of adequate counter measure for protection of the population and environment in case of radiological emergency in NPP. For the purposes of the emergency planning and response the NPP operator, ministries and the institutions developed an Emergency plan - NPP Emergency Plan and National Emergency Plan. The development of the emergency plans will be impossible without the good co-operation of the organisations which have a responsibilities in a radiological emergency. Once emergency plans are adopted, each individual organisation, also the NPP operator, must ensure that in can carry out its role effectively in accordance with the emergency plan and can develop the appropriate organisation for action and implementation of protection counter measures. For testing the emergency plans a regular exercise must be organised. Periodic reviews of the plan and modifications, based on actual events and exercise experience must be performed. The main aim of these report is to present the Bulgarian emergency planning organisation and response by explaining the national emergency panning and response legislation, implementation of IAEA recommendations and exercise experience

Public administration social responsibility of business entities

Directory of Open Access Journals (Sweden)

N. H. Shpankovskaya

2016-03-01

Full Text Available Social responsibility of a business entity is seen as an effective tool of public administration. The current stage of development of social responsibility in Ukraine requires state involvement, as its vision by business entities are different, and there is also a need to develop a national model of social responsibility on the basis of international standards, because Ukraine, on the one hand, has the national characteristics of implementation of social initiatives and, on the other, the conditions and resources for their implementation is different from developed market economies. The visions of on social responsibility in the scientific literature are also different. This was the basis for the determination of her essence. We analyzed the interpretations of social responsibility and identified their advantages and disadvantages. Formulation of social responsibility, which is submitted in article, actualizes ecological orientation of the business entity taking into account the need for responsible behavior, and responsibility for actions, which violate the norms of society.

31 CFR 50.2 - Responsible office.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Responsible office. 50.2 Section 50.2 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.2 Responsible office. The office responsible for the administration of the...

17 CFR 204.34 - Employee response.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Employee response. 204.34... DEBT COLLECTION Salary Offset § 204.34 Employee response. (a) Introduction. An employee must respond to... ways discussed in § 204.34, Employee response, and § 204.35, Petition for pre-offset hearing. Where...

Corporate moral responsibility in health care.

Science.gov (United States)

Wilmot, S

2000-01-01

The question of corporate moral responsibility--of whether it makes sense to hold an organisation corporately morally responsible for its actions, rather than holding responsible the individuals who contributed to that action--has been debated over a number of years in the business ethics literature. However, it has had little attention in the world of health care ethics. Health care in the United Kingdom (UK) is becoming an increasingly corporate responsibility, so the issue is increasingly relevant in the health care context, and it is worth considering whether the specific nature of health care raises special questions around corporate moral responsibility. For instance, corporate responsibility has usually been considered in the context of private corporations, and the organisations of health care in the UK are mainly state bodies. However, there is enough similarity in relevant respects between state organisations and private corporations, for the question of corporate responsibility to be equally applicable. Also, health care is characterised by professions with their own systems of ethical regulation. However, this feature does not seriously diminish the importance of the corporate responsibility issue, and the importance of the latter is enhanced by recent developments. But there is one major area of difference. Health care, as an activity with an intrinsically moral goal, differs importantly from commercial activities that are essentially amoral, in that it narrows the range of opportunities for corporate wrongdoing, and also makes such organisations more difficult to punish.

The nuclear response function

International Nuclear Information System (INIS)

Bertsch, G.F.

1983-01-01

These lectures present the theory of the nuclear response in the Random Phase Approximation (RPA). In the first lecture, various relations are derived between densities and currents which give rise to the well-known sum rules. Then RPA is derived via the time-dependent Hartree theory. The various formulations of RPA are shown: the configuration space representation, the coordinate space representation, the Landau theory of infinite systems and the RPA for separable interactions constrained by consistency. The remarkable success of RPA in describing the collective density oscillations of closed shell nuclei is illustrated with a few examples. In the final lecture, the σtau response is discussed with the application of simple theoretical considerations to the empirical data. Finally, we point out several problems which remain in the response theory. (author)

Rapid response learning of brand logo priming: Evidence that brand priming is not dominated by rapid response learning.

Science.gov (United States)

Boehm, Stephan G; Smith, Ciaran; Muench, Niklas; Noble, Kirsty; Atherton, Catherine

2017-08-31

Repetition priming increases the accuracy and speed of responses to repeatedly processed stimuli. Repetition priming can result from two complementary sources: rapid response learning and facilitation within perceptual and conceptual networks. In conceptual classification tasks, rapid response learning dominates priming of object recognition, but it does not dominate priming of person recognition. This suggests that the relative engagement of network facilitation and rapid response learning depends on the stimulus domain. Here, we addressed the importance of the stimulus domain for rapid response learning by investigating priming in another domain, brands. In three experiments, participants performed conceptual decisions for brand logos. Strong priming was present, but it was not dominated by rapid response learning. These findings add further support to the importance of the stimulus domain for the relative importance of network facilitation and rapid response learning, and they indicate that brand priming is more similar to person recognition priming than object recognition priming, perhaps because priming of both brands and persons requires individuation.

Methodology for combining dynamic responses

International Nuclear Information System (INIS)

Cudlin, R.; Hosford, S.; Mattu, R.; Wichman, K.

1978-09-01

The NRC has historically required that the structural/mechanical responses due to various accident loads and loads caused by natural phenomena, (such as earthquakes) be combined when analyzing structures, systems, and components important to safety. Several approaches to account for the potential interaction of loads resulting from accidents and natural phenomena have been used. One approach, the so-called absolute or linear summation (ABS) method, linearly adds the peak structural responses due to the individual dynamic loads. In general, the ABS method has also reflected the staff's conservative preference for the combination of dynamic load responses. A second approach, referred to as SRSS, yields a combined response equal to the square root of the sum of the squares of the peak responses due to the individual dynamic loads. The lack of a physical relationship between some of the loads has raised questions as to the proper methodology to be used in the design of nuclear power plants. An NRR Working Group was constituted to examine load combination methodologies and to develop a recommendation concerning criteria or conditions for their application. Evaluations of and recommendations on the use of the ABS and SRSS methods are provided in the report

Mapping "Social Responsibility" in Science

DEFF Research Database (Denmark)

Horst, Maja; Glerup, Cecilie

The paper investigates the discourse on social responsibility in science as it appears in academic journals. Through database searches a collection of more than 300 papers have been analysed in order to map their answers to the following three questions: - What is the central problem that threatens...... responsibility in science? - What are the central aspects of science or its relation to society that need to be regulated or changed? - What kinds of solutions are imagined and how are these solutions supposed to be put into place? On this basis the paper explores how different interpretations of the notion...... of social responsibility of science imply different forms of governance of and within science. The paper employs a Foucaldian discourse analysis to understand how a particular conceptualisation of responsibility implies a political rationality, i.e. a particular form of governance of science. The analysis...

Water Soluble Responsive Polymer Brushes

Directory of Open Access Journals (Sweden)

Andrew J. Parnell

2011-12-01

Full Text Available Responsive polymer brushes possess many interesting properties that enable them to control a range of important interfacial behaviours, including adhesion, wettability, surface adsorption, friction, flow and motility. The ability to design a macromolecular response to a wide variety of external stimuli makes polymer brushes an exciting class of functional materials, and has been made possible by advances in modern controlled polymerization techniques. In this review we discuss the physics of polymer brush response along with a summary of the techniques used in their synthesis. We then review the various stimuli that can be used to switch brush conformation; temperature, solvent quality, pH and ionic strength as well as the relatively new area of electric field actuation We discuss examples of devices that utilise brush conformational change, before highlighting other potential applications of responsive brushes in real world devices.

Why Pandemic Response is Unique

DEFF Research Database (Denmark)

Bækkeskov, Erik; Rubin, Olivier

2014-01-01

, the case studies of media coverage in the USA and Denmark demonstrate that the response was bureaucratized in the public health agencies (CDC and DMHA, respectively). Hence, while natural disaster responses appear to follow a political logic, the response to pandemics appears to be more strongly instituted......Purpose – The purpose of this paper is to show that 2009 H1N1 “swine” influenza pandemic vaccination policies deviated from predictions established in the theory of political survival, and to propose that pandemic response deviated because it was ruled by bureaucratized experts rather than...... by elected politicians. Design/methodology/approach – Focussing on the 2009 H1N1 pandemic, the paper employs descriptive statistical analysis of vaccination policies in nine western democracies. To probe the plausibility of the novel explanation, it uses quantitative and qualitative content analyses of media...

Granulomatous responses in larval taeniid infections.

Science.gov (United States)

Díaz, Á; Sagasti, C; Casaravilla, C

2018-05-01

Granulomas are responses to persistent nonliving bodies or pathogens, centrally featuring specialized macrophage forms called epithelioid and multinucleated giant cells. The larval stages of the cestode parasites of the Taeniidae family (Taenia, Echinococcus) develop for years in fixed tissue sites in mammals. In consequence, they are targets of granulomatous responses. The information on tissue responses to larval taeniids is fragmented among host and parasite species and scattered over many decades. We attempt to draw an integrated picture of these responses in solid tissues. The intensity of inflammation around live parasites spans a spectrum from minimal to high, parasite vitality correlating with low inflammation. The low end of the inflammatory spectrum features collagen capsules proximal to the parasites and moderate distal infiltration. The middle of the spectrum is dominated by classical granulomatous responses, whereas the high end features massive eosinophil invasions. Across the range of parasite species, much observational evidence suggests that eosinophils are highly effective at killing larval taeniids in solid tissues, before and during chronic granulomatous responses. The evidence available also suggests that these parasites are adapted to inhibit host granulomatous responses, in part through the exacerbation of host regulatory mechanisms including regulatory T cells and TGF-β. © 2018 John Wiley & Sons Ltd.

19 CFR 111.28 - Responsible supervision.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Responsible supervision. 111.28 Section 111.28 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs Brokers § 111.28 Responsible supervision. (a) General. Every individual broker...

Gut Bacteria Affect Immunotherapy Response

Science.gov (United States)

Three new studies have identified intestinal bacteria that appear to influence the response to checkpoint inhibitors. This Cancer Currents blog post explains how the researchers think their findings could be used to improve patients’ responses to these immunotherapy drugs.

40 CFR 300.110 - National Response Team.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false National Response Team. 300.110... PLAN Responsibility and Organization for Response § 300.110 National Response Team. National planning... agencies named in § 300.175(b). Each agency shall designate a member to the team and sufficient alternates...

Spaceflight Modifies Escherichia coli Gene Expression in Response to Antibiotic Exposure and Reveals Role of Oxidative Stress Response

Directory of Open Access Journals (Sweden)

Thomas R. Aunins

2018-03-01

Full Text Available Bacteria grown in space experiments under microgravity conditions have been found to undergo unique physiological responses, ranging from modified cell morphology and growth dynamics to a putative increased tolerance to antibiotics. A common theory for this behavior is the loss of gravity-driven convection processes in the orbital environment, resulting in both reduction of extracellular nutrient availability and the accumulation of bacterial byproducts near the cell. To further characterize the responses, this study investigated the transcriptomic response of Escherichia coli to both microgravity and antibiotic concentration. E. coli was grown aboard International Space Station in the presence of increasing concentrations of the antibiotic gentamicin with identical ground controls conducted on Earth. Here we show that within 49 h of being cultured, E. coli adapted to grow at higher antibiotic concentrations in space compared to Earth, and demonstrated consistent changes in expression of 63 genes in response to an increase in drug concentration in both environments, including specific responses related to oxidative stress and starvation response. Additionally, we find 50 stress-response genes upregulated in response to the microgravity when compared directly to the equivalent concentration in the ground control. We conclude that the increased antibiotic tolerance in microgravity may be attributed not only to diminished transport processes, but also to a resultant antibiotic cross-resistance response conferred by an overlapping effect of stress response genes. Our data suggest that direct stresses of nutrient starvation and acid-shock conveyed by the microgravity environment can incidentally upregulate stress response pathways related to antibiotic stress and in doing so contribute to the increased antibiotic stress tolerance observed for bacteria in space experiments. These results provide insights into the ability of bacteria to adapt under

Spaceflight Modifies Escherichia coli Gene Expression in Response to Antibiotic Exposure and Reveals Role of Oxidative Stress Response.

Science.gov (United States)

Aunins, Thomas R; Erickson, Keesha E; Prasad, Nripesh; Levy, Shawn E; Jones, Angela; Shrestha, Shristi; Mastracchio, Rick; Stodieck, Louis; Klaus, David; Zea, Luis; Chatterjee, Anushree

2018-01-01

Bacteria grown in space experiments under microgravity conditions have been found to undergo unique physiological responses, ranging from modified cell morphology and growth dynamics to a putative increased tolerance to antibiotics. A common theory for this behavior is the loss of gravity-driven convection processes in the orbital environment, resulting in both reduction of extracellular nutrient availability and the accumulation of bacterial byproducts near the cell. To further characterize the responses, this study investigated the transcriptomic response of Escherichia coli to both microgravity and antibiotic concentration. E. coli was grown aboard International Space Station in the presence of increasing concentrations of the antibiotic gentamicin with identical ground controls conducted on Earth. Here we show that within 49 h of being cultured, E. coli adapted to grow at higher antibiotic concentrations in space compared to Earth, and demonstrated consistent changes in expression of 63 genes in response to an increase in drug concentration in both environments, including specific responses related to oxidative stress and starvation response. Additionally, we find 50 stress-response genes upregulated in response to the microgravity when compared directly to the equivalent concentration in the ground control. We conclude that the increased antibiotic tolerance in microgravity may be attributed not only to diminished transport processes, but also to a resultant antibiotic cross-resistance response conferred by an overlapping effect of stress response genes. Our data suggest that direct stresses of nutrient starvation and acid-shock conveyed by the microgravity environment can incidentally upregulate stress response pathways related to antibiotic stress and in doing so contribute to the increased antibiotic stress tolerance observed for bacteria in space experiments. These results provide insights into the ability of bacteria to adapt under extreme stress

Spaceflight Modifies Escherichia coli Gene Expression in Response to Antibiotic Exposure and Reveals Role of Oxidative Stress Response

Science.gov (United States)

Aunins, Thomas R.; Erickson, Keesha E.; Prasad, Nripesh; Levy, Shawn E.; Jones, Angela; Shrestha, Shristi; Mastracchio, Rick; Stodieck, Louis; Klaus, David; Zea, Luis; Chatterjee, Anushree

2018-01-01

Bacteria grown in space experiments under microgravity conditions have been found to undergo unique physiological responses, ranging from modified cell morphology and growth dynamics to a putative increased tolerance to antibiotics. A common theory for this behavior is the loss of gravity-driven convection processes in the orbital environment, resulting in both reduction of extracellular nutrient availability and the accumulation of bacterial byproducts near the cell. To further characterize the responses, this study investigated the transcriptomic response of Escherichia coli to both microgravity and antibiotic concentration. E. coli was grown aboard International Space Station in the presence of increasing concentrations of the antibiotic gentamicin with identical ground controls conducted on Earth. Here we show that within 49 h of being cultured, E. coli adapted to grow at higher antibiotic concentrations in space compared to Earth, and demonstrated consistent changes in expression of 63 genes in response to an increase in drug concentration in both environments, including specific responses related to oxidative stress and starvation response. Additionally, we find 50 stress-response genes upregulated in response to the microgravity when compared directly to the equivalent concentration in the ground control. We conclude that the increased antibiotic tolerance in microgravity may be attributed not only to diminished transport processes, but also to a resultant antibiotic cross-resistance response conferred by an overlapping effect of stress response genes. Our data suggest that direct stresses of nutrient starvation and acid-shock conveyed by the microgravity environment can incidentally upregulate stress response pathways related to antibiotic stress and in doing so contribute to the increased antibiotic stress tolerance observed for bacteria in space experiments. These results provide insights into the ability of bacteria to adapt under extreme stress

Commercial Building Motor Protection Response Report

Energy Technology Data Exchange (ETDEWEB)

James, Daniel P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kueck, John [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2015-06-17

When voltages recover, motors may immediately reenergize and reaccelerate, or delay for a few minutes, or stay stalled. The estimated motor response is given for both the voltage sag magnitude and voltage sag duration. These response estimates are based on experience and available test data. Good data is available for voltage sag response for many components such as relays and contactors, but little data is available for both voltage sag and recovery response. The tables in Appendix A include data from recent voltage sag and recovery tests performed by SCE and BPA on air conditioners and energy management systems. The response of the motor can vary greatly depending on the type of protection and control. The time duration for the voltage sag consists of those times that are of interest for bulk power system modelers.

Plasmonic nanostructures: local versus nonlocal response

DEFF Research Database (Denmark)

Toscano, Giuseppe; Wubs, Martijn; Xiao, Sanshui

2010-01-01

, and hence it is sensitive to possible narrow resonances that may arise due to strong electronic quantum confinement in the metal. This feature allows us to accurately determine which geometries are strongly affected by nonlocal response, for example regarding applications based on electric field enhancement......We study the importance of taking the nonlocal optical response of metals into account for accurate determination of optical properties of nanoplasmonic structures. Here we focus on the computational physics aspects of this problem, and in particular we report on the nonlocal-response package...... that we wrote for state-of the art numerical software, enabling us to take into account the nonlocal material response of metals for any arbitrarily shaped nanoplasmonic structures, without much numerical overhead as compared to the standard local response. Our method is a frequency-domain method...

Humanitarian response: improving logistics to save lives.

Science.gov (United States)

McCoy, Jessica

2008-01-01

Each year, millions of people worldwide are affected by disasters, underscoring the importance of effective relief efforts. Many highly visible disaster responses have been inefficient and ineffective. Humanitarian agencies typically play a key role in disaster response (eg, procuring and distributing relief items to an affected population, assisting with evacuation, providing healthcare, assisting in the development of long-term shelter), and thus their efficiency is critical for a successful disaster response. The field of disaster and emergency response modeling is well established, but the application of such techniques to humanitarian logistics is relatively recent. This article surveys models of humanitarian response logistics and identifies promising opportunities for future work. Existing models analyze a variety of preparation and response decisions (eg, warehouse location and the distribution of relief supplies), consider both natural and manmade disasters, and typically seek to minimize cost or unmet demand. Opportunities to enhance the logistics of humanitarian response include the adaptation of models developed for general disaster response; the use of existing models, techniques, and insights from the literature on commercial supply chain management; the development of working partnerships between humanitarian aid organizations and private companies with expertise in logistics; and the consideration of behavioral factors relevant to a response. Implementable, realistic models that support the logistics of humanitarian relief can improve the preparation for and the response to disasters, which in turn can save lives.

Advances in Crash Response

Centers for Disease Control (CDC) Podcasts

2009-06-29

In this podcast, Dr. Richard C. Hunt, Director of CDC's Division of Injury Response, provides an overview on the benefits of using an Advanced Automatic Collision Notification system, or AACN, to help with emergency triage of people injured in vehicle crashes.  Created: 6/29/2009 by National Center for Injury Prevention and Control (NCIPC), Division of Injury Response (DIR).   Date Released: 6/29/2009.

Social Responsibility of Accounting

OpenAIRE

JINNAI, Yoshiaki

2011-01-01

Historical and theoretical inquiries into the function of accounting have provided fruitful insights into social responsibility of accounting, which is, and should be, based on accounts kept through everyday accounting activities. However, at the current stage of capitalist accounting, keeping accounts is often regarded as merely a preparatory process for creating financial statements at the end of an accounting period. Thus, discussions on the social responsibility of accounting tend to conc...

Distinguishing stimulus and response codes in theta oscillations in prefrontal areas during inhibitory control of automated responses.

Science.gov (United States)

Mückschel, Moritz; Dippel, Gabriel; Beste, Christian

2017-11-01

Response inhibition mechanisms are mediated via cortical and subcortical networks. At the cortical level, the superior frontal gyrus, including the supplementary motor area (SMA) and inferior frontal areas, is important. There is an ongoing debate about the functional roles of these structures during response inhibition as it is unclear whether these structures process different codes or contents of information during response inhibition. In the current study, we examined this question with a focus on theta frequency oscillations during response inhibition processes. We used a standard Go/Nogo task in a sample of human participants and combined different EEG signal decomposition methods with EEG beamforming approaches. The results suggest that stimulus coding during inhibitory control is attained by oscillations in the upper theta frequency band (∼7 Hz). In contrast, response selection codes during inhibitory control appear to be attained by the lower theta frequency band (∼4 Hz). Importantly, these different codes seem to be processed in distinct functional neuroanatomical structures. Although the SMA may process stimulus codes and response selection codes, the inferior frontal cortex may selectively process response selection codes during inhibitory control. Taken together, the results suggest that different entities within the functional neuroanatomical network associated with response inhibition mechanisms process different kinds of codes during inhibitory control. These codes seem to be reflected by different oscillations within the theta frequency band. Hum Brain Mapp 38:5681-5690, 2017. © 2017 Wiley-Liss, Inc. © 2017 Wiley Periodicals, Inc.

Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose-response curves

International Nuclear Information System (INIS)

Conolly, Rory B.; Gaylor, David W.; Lutz, Werner K.

2005-01-01

Carcinogen dose-response curves for both ionizing radiation and chemicals are typically assumed to be linear at environmentally relevant doses. This assumption is used to ensure protection of the public health in the absence of relevant dose-response data. A theoretical justification for the assumption has been provided by the argument that low dose linearity is expected when an exogenous agent adds to an ongoing endogenous process. Here, we use computational modeling to evaluate (1) how two biological adaptive processes, induction of DNA repair and cell cycle checkpoint control, may affect the shapes of dose-response curves for DNA-damaging carcinogens and (2) how the resulting dose-response behaviors may vary within a population. Each model incorporating an adaptive process was capable of generating not only monotonic dose-responses but also nonmonotonic (J-shaped) and threshold responses. Monte Carlo analysis suggested that all these dose-response behaviors could coexist within a population, as the spectrum of qualitative differences arose from quantitative changes in parameter values. While this analysis is largely theoretical, it suggests that (a) accurate prediction of the qualitative form of the dose-response requires a quantitative understanding of the mechanism (b) significant uncertainty is associated with human health risk prediction in the absence of such quantitative understanding and (c) a stronger experimental and regulatory focus on biological mechanisms and interindividual variability would allow flexibility in regulatory treatment of environmental carcinogens without compromising human health

The Importance of Responsibility in Times of Crisis

Directory of Open Access Journals (Sweden)

Jacob Dahl Rendtorff

2014-06-01

Full Text Available In this paper I would like to show the importance of the concept of responsibility as the foundation of ethics in times of crisis in particular in the fields of politics and economics in the modern civilisation marked by globalization and technological progres. I consider the concept of responsibility as the key notion in order to understand the ethical duty in a modern technological civilisation. We can indeed observe a moralization of the concept of responsibility going beyond a strict legal definition in terms of imputability. The paper begins by discussing the humanistic foundations of such a concept of responsibility. It treats the historical origins of responsibility and it relates this concept to the concept of accountability. On the basis of this historical determination of the concept I would like to present the definition of the concept of responsibility as fundamental ethical principle that has increasing importance as the foundation of the principles of governance in modern welfare states. In this context the paper discusses the extension of the concept of responsibility towards institutional or corporate responsibility where responsibility does not only concerns the responsibility of individuals but also deals with the responsibility of institutional collectivities. In this way the paper is based on the following structure : 1 The ethical foundation of the concept of responsibility 2 Responsibility in technological civilisation 3 Political responsibility for good governance in the welfare state 4 Social responsibility of business corporations in times of globalization 5 Conclusion and discussion : changed conditions of responsibility in modern times.

Responses Following Sexual and Non-Sexual Assault.

Science.gov (United States)

Rothbaum, Barbara Olasov; And Others

Assault victims exhibit a variety of emotional responses including fear, depression, and sexual impairment. For most assault victims, these responses decline over time. This study examined the pattern of post-assault responses during the first 12 weeks and compared the pattern of responses following rape with non-sexual criminal assault reactions.…

Structural and containment response to LMFBR accidents

International Nuclear Information System (INIS)

Marchaterre, J.F.; Fistedis, S.H.; Baker, L. Jr.; Stepnewski, D.D.; Peak, R.D.; Gluekler, E.L.

1978-01-01

The results of current developments in analysing the response of reactor structures and containment to LMFBR accidents are presented. The current status of analysis of the structural response of LMFBR's to core disruptive accidents, including head response, potential missile generation and the effects of internal structures are presented. The results of recent experiments to help clarify the thermal response of reactor structures to molten core debris are summarized, including the use of this data to calculate the response of the secondary containment. (author)

Anal sphincter responses after perianal electrical stimulation

DEFF Research Database (Denmark)

Pedersen, Ejnar; Klemar, B; Schrøder, H D

1982-01-01

By perianal electrical stimulation and EMG recording from the external anal sphincter three responses were found with latencies of 2-8, 13-18 and 30-60 ms, respectively. The two first responses were recorded in most cases. They were characterised by constant latency and uniform pattern, were...... not fatigued by repeated stimulation, were most dependent on placement of stimulating and recording electrodes, and always had a higher threshold than the third response. The third response was constantly present in normal subjects. It had the longest EMG response and the latency decreased with increasing...... stimulation to a minimum of 30-60 ms. This response represented the clinical observable spinal reflex, "the classical anal reflex". The latencies of the two first responses were so short that they probably do not represent spinal reflexes. This was further supported by the effect of epidural anaesthesia which...

Science and social responsibility in public health.

Science.gov (United States)

Weed, Douglas L; McKeown, Robert E

2003-01-01

Epidemiologists and environmental health researchers have a joint responsibility to acquire scientific knowledge that matters to public health and to apply the knowledge gained in public health practice. We examine the nature and source of these social responsibilities, discuss a debate in the epidemiological literature on roles and responsibilities, and cite approaches to environmental justice as reflective of them. At one level, responsibility refers to accountability, as in being responsible for actions taken. A deeper meaning of responsibility corresponds to commitment to the pursuit and achievement of a valued end. Epidemiologists are committed to the scientific study of health and disease in human populations and to the application of scientific knowledge to improve the public's health. Responsibility is also closely linked to reliability. Responsible professionals reliably perform the tasks they set for themselves as well as the tasks society expects them to undertake. The defining axiom for our approach is that the health of the public is a social good we commit ourselves to pursue, thus assuming an obligation to contribute to its achievement. Epidemiologists cannot claim to be committed to public health as a social good and not accept the responsibility of ensuring that the knowledge gained in their roles as scientists is used to achieve that good. The social responsibilities of environmental health researchers are conspicuous in the environmental justice movement, for example, in community-based participatory research. Responsibility is an ethical concept particularly well suited to frame many key aspects of the ethics of our profession. PMID:14602514

The Burden of Power: Construing Power as Responsibility (Rather Than as Opportunity) Alters Threat-Challenge Responses.

Science.gov (United States)

Scholl, Annika; de Wit, Frank; Ellemers, Naomi; Fetterman, Adam K; Sassenberg, Kai; Scheepers, Daan

2018-07-01

Power usually lowers stress responses. In stressful situations, having high (vs. low) power heightens challenge and lowers threat. Yet, even power-holders may experience threat when becoming aware of the responsibility that accompanies their power. Power-holders can construe (i.e., understand) a high-power position primarily as opportunity to "make things happen" or as responsibility to "take care of things." Power-holders construing power as responsibility (rather than opportunity) may be more likely to experience demands-such as taking care of important decisions under their control-as outweighing their resources, resulting in less challenge and more threat. Four experiments with subjective and cardiovascular threat-challenge indicators support this. Going beyond prior work on structural aspects (e.g., power instability) that induce stress, we show that merely the way how power-holders construe their power can evoke stress. Specifically, we find that power construed as responsibility (vs. opportunity) is more likely to imply a "burden" for the power-holder.

Wave kinematics and response of slender offshore structures. Vol 5: Wave forces and responses

Energy Technology Data Exchange (ETDEWEB)

Pedersen, L.M.; Riber, H.J.

1999-08-01

A load measuring system (LMS) and a wave measuring system (WMS) has been used on the North Sea platform Tyra. The LMS consists of an instrumented pipe placed vertically in the crest zone of high and steep waves. The WMS consists of an unique sonar system placed on the sea floor. Simultaneous measurements are carried out of the kinematics of waves and currents and the response of the instrumented pipe during a period of five month in the winter 1994/95. Numerical calculations with LIC22 are carried out of the response of the LMS applying the measured wave and current kinematics. The responses are compared to the measured responses of the LMS. The comparison is based on the statistical main properties of the calculated and measured response as the kinematic field is measured 150 metres away from the instrumented pipe. From the analyses the main parameters (reduced velocity V{sub R} and correlation length l{sub c}) for vortex induced vibrations (VIV) are calibrated and the main environmental conditions for VIV are determined. The hydrodynamic coefficients determining the wave and current forces on slender structures are studied (drag coefficient C{sub D} and added mass coefficient C{sub M}). Further, the effect on the drag coefficient due to air blending in the upper part of the wave is determined. (au)

Dose-response-a challenge for allelopathy?

Science.gov (United States)

Belz, Regina G; Hurle, Karl; Duke, Stephen O

2005-04-01

The response of an organism to a chemical depends, among other things, on the dose. Nonlinear dose-response relationships occur across a broad range of research fields, and are a well established tool to describe the basic mechanisms of phytotoxicity. The responses of plants to allelochemicals as biosynthesized phytotoxins, relate as well to nonlinearity and, thus, allelopathic effects can be adequately quantified by nonlinear mathematical modeling. The current paper applies the concept of nonlinearity to assorted aspects of allelopathy within several bioassays and reveals their analysis by nonlinear regression models. Procedures for a valid comparison of effective doses between different allelopathic interactions are presented for both, inhibitory and stimulatory effects. The dose-response applications measure and compare the responses produced by pure allelochemicals [scopoletin (7-hydroxy-6-methoxy-2H-1-benzopyran-2-one); DIBOA (2,4-dihydroxy-2H-1,4-benzoxaxin-3(4H)-one); BOA (benzoxazolin-2(3H)-one); MBOA (6-methoxy-benzoxazolin-2(3H)-one)], involved in allelopathy of grain crops, to demonstrate how some general principles of dose responses also relate to allelopathy. Hereupon, dose-response applications with living donor plants demonstrate the validity of these principles for density-dependent phytotoxicity of allelochemicals produced and released by living plants (Avena sativa L., Secale cereale L., Triticum L. spp.), and reveal the use of such experiments for initial considerations about basic principles of allelopathy. Results confirm that nonlinearity applies to allelopathy, and the study of allelopathic effects in dose-response experiments allows for new and challenging insights into allelopathic interactions.

Identifying mechanistic similarities in drug responses

KAUST Repository

Zhao, C.

2012-05-15

Motivation: In early drug development, it would be beneficial to be able to identify those dynamic patterns of gene response that indicate that drugs targeting a particular gene will be likely or not to elicit the desired response. One approach would be to quantitate the degree of similarity between the responses that cells show when exposed to drugs, so that consistencies in the regulation of cellular response processes that produce success or failure can be more readily identified.Results: We track drug response using fluorescent proteins as transcription activity reporters. Our basic assumption is that drugs inducing very similar alteration in transcriptional regulation will produce similar temporal trajectories on many of the reporter proteins and hence be identified as having similarities in their mechanisms of action (MOA). The main body of this work is devoted to characterizing similarity in temporal trajectories/signals. To do so, we must first identify the key points that determine mechanistic similarity between two drug responses. Directly comparing points on the two signals is unrealistic, as it cannot handle delays and speed variations on the time axis. Hence, to capture the similarities between reporter responses, we develop an alignment algorithm that is robust to noise, time delays and is able to find all the contiguous parts of signals centered about a core alignment (reflecting a core mechanism in drug response). Applying the proposed algorithm to a range of real drug experiments shows that the result agrees well with the prior drug MOA knowledge. © The Author 2012. Published by Oxford University Press. All rights reserved.

Stationary and Transient Response Statistics

DEFF Research Database (Denmark)

Madsen, Peter Hauge; Krenk, Steen

1982-01-01

The covariance functions for the transient response of a linear MDOF-system due to stationary time limited excitation with an arbitrary frequency content are related directly to the covariance functions of the stationary response. For rational spectral density functions closed form expressions fo...

Responsibility/Nonresponsibility in Pyschosomatic Disorders.

Science.gov (United States)

Greenwald, Deborah F.

1984-01-01

Interviewed 40 men to investigate the hypothesis that gastrointestinal and dermatological symptoms are associated with differing psychological styles and responses to the environment. Results suggested a responsive style is associated with gastrointestinal symptoms and a nonresponsive style is associated with dermatological symptoms. (JAC)

Immune response to H pylori

Science.gov (United States)

Suarez, Giovanni; Reyes, Victor E; Beswick, Ellen J

2006-01-01

The gastric mucosa separates the underlying tissue from the vast array of antigens that traffic through the stomach lumen. While the extreme pH of this environment is essential in aiding the activation of enzymes and food digestion, it also renders the gastric epithelium free from bacterial colonization, with the exception of one important human pathogen, H pylori. This bacterium has developed mechanisms to survive the harsh environment of the stomach, actively move through the mucosal layer, attach to the epithelium, evade immune responses, and achieve persistent colonization. While a hallmark of this infection is a marked inflammatory response with the infiltration of various immune cells into the infected gastric mucosa, the host immune response is unable to clear the infection and may actually contribute to the associated pathogenesis. Here, we review the host responses involved during infection with H pylori and how they are influenced by this bacterium. PMID:17007009

Social responsibility in nursing education.

Science.gov (United States)

Mayo, K

1996-03-01

Nurses will be key participants in health care reform as health care shifts from a hospital-based disease orientation to a community-centered health promotion focus. Nursing in communities, the environmental context of clients' everyday lives, requires attention to social, economic, and political circumstances that influence health status and access to health care. Therefore, nursing educators have the responsibility to prepare future nurses for community-based practice by instilling moral and professional practice obligations, cultural sensitivity, and other facets of social responsibility. In this article, social responsibility and journaling, a teaching/learning strategy suggested by the new paradigm approach of the curriculum revolution, are explored. A qualitative research study of more than 100 nursing student journal entries illustrates the concept of social responsibility and how it developed in a group of baccalaureate nursing students during a clinical practicum in a large urban homeless shelter.

Using Response Times to Assess Learning Progress: A Joint Model for Responses and Response Times

Science.gov (United States)

Wang, Shiyu; Zhang, Susu; Douglas, Jeff; Culpepper, Steven

2018-01-01

Analyzing students' growth remains an important topic in educational research. Most recently, Diagnostic Classification Models (DCMs) have been used to track skill acquisition in a longitudinal fashion, with the purpose to provide an estimate of students' learning trajectories in terms of the change of fine-grained skills overtime. Response time…

Shallow End Response from ATEM

Science.gov (United States)

Vetrov, A.

2014-12-01

Different geological, hydrological, environmental and engineering targets are located shallow underground. The information collected with ATEM systems might be very useful for their study; although there are many deeper targets that the ATEM systems are traditionally used for. The idea to raise magnetic moment output and get deeper penetration response was one of the goals of ATEM systems development during the last decade. The shallow geology response was a trade for such systems, which sometimes were almost blind in the first hundred meter under surface. The possibility to achieve shallow end response from ATEM systems has become significant subject in last years. Several airborne TDEM systems got second higher frequency and lower magnetic moment signal to pick up shallow response together with deep one. Having a potential advantage such implementation raises complication and cost of the system. There's no need to receive 500 meter deep response when exploring shallow geology. P-THEM system having a compact size transmitter and relatively light weight is working on one base frequency at a time, but this frequency can be preset before a flight considering survey goals. A study of shallow geology response of the P-THEM system working on different base frequency has been conducted in 2014 in Ontario. The Alliston test area located in Southern Ontario has been flown with the P-THEM system working on base frequencies 30Hz and 90Hz. Results of the observations will be discussed in the presentation. The shallow end data can be used for mineral exploration applications and also for hydrological and environmental studies.

Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses1

OpenAIRE

Allam, Atef; Swiecki, Melissa; Vermi, William; Ashwell, Jonathan D.; Colonna, Marco

2014-01-01

The role of the tumor necrosis factor family member CD70 in adaptive T cell responses has been intensively studied but its function in innate responses is still under investigation. Here we show that CD70 inhibits the early innate response to murine cytomegalovirus (MCMV) but is essential for the optimal generation of virus-specific CD8 T cells. CD70-/- mice reacted to MCMV infection with a robust type I interferon and proinflammatory cytokine response. This response was sufficient for initia...

Functional analysis of the stress response element and its role in the multistress response of Saccharomyces cerevisiae.

Science.gov (United States)

Treger, J M; Magee, T R; McEntee, K

1998-02-04

The DDR2 gene of Saccharomyces cerevisiae is a multistress response gene whose transcription is rapidly and strongly induced by a diverse array of xenobiotic agents, and environmental and physiological conditions. The multistress response of this gene requires the pentanucleotide, 5' CCCCT, (C4T;STRE (STress Response Element)) and the zinc-finger transcription factors, Msn2p and Msn4p. A 51bp oligonucleotide (oligo 31/32) containing two STREs from the DDR2 promoter region was previously shown to direct heat shock activation of a lacZ reporter gene. In this work we demonstrate that the same element conferred a complete multistress response to an E. coli galK reporter gene introduced into yeast cells. A variant oligonucleotide in which both the STRE spacing and neighboring sequences were altered responded to the same spectrum of stresses, while substitution of nucleotides within the pentanucleotide completely abolished the multistress response. These results directly demonstrate that STREs are not only necessary but are sufficient for mediating a transcriptional response to a surprisingly diverse set of environmental and physiological conditions.

Aspects of Responsible Tourism ‒ A Quantitative Approach

Directory of Open Access Journals (Sweden)

Olimpia State

2016-11-01

Full Text Available The concept of responsibility is well-known, but its association with tourism and connections with different aspects studied extensively, such as ethics, social responsibility, sustainable development and sustainable tourism, offers multiple research options. The main aim of this article is to define responsible tourism and to characterize responsible tourist. To define responsible tourism were seeking answers to the following questions: What are the main characteristics of responsible tourism? What known concepts can be associated with responsible tourism and with which forms of tourism is more suitable? And who are stakeholders in promotion and development of res ponsible tourism principles? To characterize responsible tourist, research answer to the following questions: What aspects define a responsible tourist? And, in this context, is a responsible attitude to travel and discover your own country? A secondary objective of the research is the statistical testing of correlations between respondents' characteristics and their opinion about the responsibility in tourism. The study is based on quantitative research ‒ a questionnaire applied to Romanian tourists in the period of March-May 2015.

Lobbying and the Responsible Firm

DEFF Research Database (Denmark)

Anastasiadis, Stephanos; Moon, Jeremy; Humphreys, Michael

2018-01-01

“Responsible lobbying” is an increasingly salient topic within business and management. We make a contribution to the literature on “responsible lobbying” in three ways. First, we provide novel definitions and, thereby, make a clear distinction between lobbying and corporate political activity. W...

Comparison study of time history and response spectrum responses for multiply supported piping systems

International Nuclear Information System (INIS)

Wang, Y.K.; Subudhi, M.; Bezler, P.

1983-01-01

In the past decade, several investigators have studied the problem of independent support excitation of a multiply supported piping system to identify the real need for such an analysis. This approach offers an increase in accuracy at a small increase in computational costs. To assess the method, studies based on the response spectrum approach using independent support motions for each group of commonly connected supports were performed. The results obtained from this approach were compared with the conventional envelope spectrum and time history solutions. The present study includes a mathematical formulation of the independent support motion analysis method suitable for implementation into an existing all purpose piping code PSAFE2 and a comparison of the solutions for some typical piping system using both Time History and Response Spectrum Methods. The results obtained from the Response Spectrum Methods represent the upper bound solution at most points in the piping system. Similarly, the Seismic Anchor Movement analysis based on the SRP method over predicts the responses near the support points and under predicts at points away from the supports

Honours service-learning & civic responsibility

Directory of Open Access Journals (Sweden)

Trae Stewart

2012-03-01

Full Text Available 800x600 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Universities have been urged to prepare graduates for successful professional lives and fulfilling lives as civically responsible citizens. Pedagogies of engagement, like service-learning, are touted as one means to achieve these goals. Connections between first-year experience and service-learning programs have been slow to develop. Further, empirical studies on service-learning in university honours education are similarly scarce. This article examines first-semester honours postsecondary students' sense of civic responsibility before and after completing a service-learning program linking a course on the Evolution of Community to direct volunteerism in struggling schools. Based on pre-post-responses (n=119 to the Level III-Civic Responsibility Survey, analysis of variance with repeated measures showed that participants' sense of civic responsibility was significantly increased over time on each of the dependent variables (i.e., community connectedness, civic attitudes, civic efficacy. Community connectedness scores increased significantly at the .005 level, F(1, 118 = 9.703, p = .002. The changes in civic attitudes and civic efficacy scores were extremely significant at the .0005 level, F(1, 118 = 14.498, p < .0005 and F(1, 118 = 23.56, p < .0005, respectively.

Response spectrum analysis of coupled structural response to a three component seismic disturbance

International Nuclear Information System (INIS)

Boulet, J.A.M.; Carley, T.G.

1977-01-01

The work discussed herein is a comparison and evaluation of several response spectrum analysis (RSA) techniques as applied to the same structural model with seismic excitation having three spatial components. The structural model includes five lumped masses (floors) connected by four elastic members. The base is supported by three translational springs and two horizontal torsional springs. In general, the mass center and shear center of a building floor are distinct locations. Hence, inertia forces, which act at the mass center, induce twisting in the structure. Through this induced torsion, the lateral (x and y) displacements of the mass elements are coupled. The ground motion components used for this study are artificial earthquake records generated from recorded accelerograms by a spectrum modification technique. The accelerograms have response spectra which are compatible with U.S. NRC Regulatory Guide 1.60. Lagrange's equations of motion for the system were written in matrix form and uncoupled with the modal matrix. Numerical integration (fourth order Runge-Kutta) of the resulting modal equations produced time histories of system displacements in response to simultaneous application of three orthogonal components of ground motion, and displacement response spectra for each modal coordinate in response to each of the three ground motion components. Five different RSA techniques were used to combine the spectral displacements and the modal matrix to give approximations of maximum system displacements. These approximations were then compared with the maximum system displacements taken from the time histories. The RSA techniques used are the method of absolute sums, the square root of the sum of the sum of the squares, the double sum approach, the method of closely spaced modes, and Lin's method

In Response

Science.gov (United States)

Egeland, Janice A.; Shaw, Jon A.; Endicott, Jean; Allen, Cleona R.; Hostetter, Abram M.

2005-01-01

This article features the response to the important commentary by Dr. Carlson. The Amish Study represents, as she notes, a special research population for investigation of "classic" bipolar disorder viewed against a homogeneous cultural landscape where emerging biological and behavioral prodromal features can be identified. Dr. Carlson questions…

A review: Development of a microdose model for analysis of adaptive response and bystander dose response behavior.

Science.gov (United States)

Leonard, Bobby E

2008-02-27

Prior work has provided incremental phases to a microdosimetry modeling program to describe the dose response behavior of the radio-protective adaptive response effect. We have here consolidated these prior works (Leonard 2000, 2005, 2007a, 2007b, 2007c) to provide a composite, comprehensive Microdose Model that is also herein modified to include the bystander effect. The nomenclature for the model is also standardized for the benefit of the experimental cellular radio-biologist. It extends the prior work to explicitly encompass separately the analysis of experimental data that is 1.) only dose dependent and reflecting only adaptive response radio-protection, 2.) both dose and dose-rate dependent data and reflecting only adaptive response radio-protection for spontaneous and challenge dose damage, 3.) only dose dependent data and reflecting both bystander deleterious damage and adaptive response radio-protection (AR-BE model). The Appendix cites the various applications of the model. Here we have used the Microdose Model to analyze the, much more human risk significant, Elmore et al (2006) data for the dose and dose rate influence on the adaptive response radio-protective behavior of HeLa x Skin cells for naturally occurring, spontaneous chromosome damage from a Brachytherapy type (125)I photon radiation source. We have also applied the AR-BE Microdose Model to the Chromosome inversion data of Hooker et al (2004) reflecting both low LET bystander and adaptive response effects. The micro-beam facility data of Miller et al (1999), Nagasawa and Little (1999) and Zhou et al (2003) is also examined. For the Zhou et al (2003) data, we use the AR-BE model to estimate the threshold for adaptive response reduction of the bystander effect. The mammogram and diagnostic X-ray induction of AR and protective BE are observed. We show that bystander damage is reduced in the similar manner as spontaneous and challenge dose damage as shown by the Azzam et al (1996) data. We cite

Item response theory - A first approach

Science.gov (United States)

Nunes, Sandra; Oliveira, Teresa; Oliveira, Amílcar

2017-07-01

The Item Response Theory (IRT) has become one of the most popular scoring frameworks for measurement data, frequently used in computerized adaptive testing, cognitively diagnostic assessment and test equating. According to Andrade et al. (2000), IRT can be defined as a set of mathematical models (Item Response Models - IRM) constructed to represent the probability of an individual giving the right answer to an item of a particular test. The number of Item Responsible Models available to measurement analysis has increased considerably in the last fifteen years due to increasing computer power and due to a demand for accuracy and more meaningful inferences grounded in complex data. The developments in modeling with Item Response Theory were related with developments in estimation theory, most remarkably Bayesian estimation with Markov chain Monte Carlo algorithms (Patz & Junker, 1999). The popularity of Item Response Theory has also implied numerous overviews in books and journals, and many connections between IRT and other statistical estimation procedures, such as factor analysis and structural equation modeling, have been made repeatedly (Van der Lindem & Hambleton, 1997). As stated before the Item Response Theory covers a variety of measurement models, ranging from basic one-dimensional models for dichotomously and polytomously scored items and their multidimensional analogues to models that incorporate information about cognitive sub-processes which influence the overall item response process. The aim of this work is to introduce the main concepts associated with one-dimensional models of Item Response Theory, to specify the logistic models with one, two and three parameters, to discuss some properties of these models and to present the main estimation procedures.

32 CFR 100.4 - Responsibility.

Science.gov (United States)

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Responsibility. 100.4 Section 100.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN UNSATISFACTORY PERFORMANCE OF READY RESERVE OBLIGATION § 100.4 Responsibility. The Secretaries of the Military...

32 CFR 542.6 - Responsibilities.

Science.gov (United States)

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Responsibilities. 542.6 Section 542.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY EDUCATION SCHOOLS AND COLLEGES § 542.6 Responsibilities. (a) The Commanding General, US Army Military Personnel Center, 200 Stovall...

Gender and international crisis response

DEFF Research Database (Denmark)

Eklund, Lisa; Tellier, Siri

2012-01-01

For more than a decade the humanitarian community has been mandated to mainstream gender in its response to crises. One element of this mandate is a repeated call for sex-disaggregated data to help guide the response. This study examines available analyses, assessments and academic literature to ...

12 CFR 403.2 - Responsibilities.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Responsibilities. 403.2 Section 403.2 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES CLASSIFICATION, DECLASSIFICATION, AND SAFEGUARDING OF NATIONAL SECURITY INFORMATION § 403.2 Responsibilities. In the carrying out of security procedures...

Modelling sequentially scored item responses

NARCIS (Netherlands)

Akkermans, W.

2000-01-01

The sequential model can be used to describe the variable resulting from a sequential scoring process. In this paper two more item response models are investigated with respect to their suitability for sequential scoring: the partial credit model and the graded response model. The investigation is

Randomized Item Response Theory Models

NARCIS (Netherlands)

Fox, Gerardus J.A.

2005-01-01

The randomized response (RR) technique is often used to obtain answers on sensitive questions. A new method is developed to measure latent variables using the RR technique because direct questioning leads to biased results. Within the RR technique is the probability of the true response modeled by

Bringing Professional Responsibility Back in

Science.gov (United States)

Solbrekke, Tone Dyrdal; Englund, Tomas

2011-01-01

Research on how higher education institutions work with professional formation indicates that insufficient attention is currently paid to issues of professional responsibility and ethics. In the light of such findings, there is increasing concern about issues related to learning professional responsibility. This article concentrates on different…

Responsibility structure in medical radiation applications

International Nuclear Information System (INIS)

Beekman, Z.M.

1989-01-01

The author discusses the various aspects of the responsibilities of physicians and clinical physicists with regard to radiation protection in medical applications of ionizing radiation. It becomes still clearer that the physician, who carries out the examination or the treatment, also has to bear the responsibility. this holds for the indication assessment as well as for optimization of the quality of the examination or treatment versus radiation burden of the patient, radiologic worker and thirds. Further it is clear that the physician in these will have to delegate specific tasks and responsibilities, whether or not in the elongated-arm construction. The clinical physicist is responsible in particular for the applications of the physical methods and watches the quality of the apparatus and methods used. As such he also is responsible for the technical workers, who take care of the preventive and corrective maintenance. The principal responsibility of the clinical physicist however lies in the field of standardization and calibration of medical-physical instruments. Besides this investigation into and development of new techniques, methods and apparatus come up, while also education and training of various profession groups involved need attention. (author). 6 refs.; 1 tab

Emotional response to musical repetition.

Science.gov (United States)

Livingstone, Steven R; Palmer, Caroline; Schubert, Emery

2012-06-01

Two experiments examined the effects of repetition on listeners' emotional response to music. Listeners heard recordings of orchestral music that contained a large section repeated twice. The music had a symmetric phrase structure (same-length phrases) in Experiment 1 and an asymmetric phrase structure (different-length phrases) in Experiment 2, hypothesized to alter the predictability of sensitivity to musical repetition. Continuous measures of arousal and valence were compared across music that contained identical repetition, variation (related), or contrasting (unrelated) structure. Listeners' emotional arousal ratings differed most for contrasting music, moderately for variations, and least for repeating musical segments. A computational model for the detection of repeated musical segments was applied to the listeners' emotional responses. The model detected the locations of phrase boundaries from the emotional responses better than from performed tempo or physical intensity in both experiments. These findings indicate the importance of repetition in listeners' emotional response to music and in the perceptual segmentation of musical structure.

Angular response of hot wire probes

International Nuclear Information System (INIS)

Di Mare, L; Jelly, T O; Day, I J

2017-01-01

A new equation for the convective heat loss from the sensor of a hot-wire probe is derived which accounts for both the potential and the viscous parts of the flow past the prongs. The convective heat loss from the sensor is related to the far-field velocity by an expression containing a term representing the potential flow around the prongs, and a term representing their viscous effect. This latter term is absent in the response equations available in the literature but is essential in representing some features of the observed response of miniature hot-wire probes. The response equation contains only four parameters but it can reproduce, with great accuracy, the behaviour of commonly used single-wire probes. The response equation simplifies the calibration the angular response of rotated slanted hot-wire probes: only standard King’s law parameters and a Reynolds-dependent drag coefficient need to be determined. (paper)

Rocking response of tanks containing two liquids

International Nuclear Information System (INIS)

Tang Yu

1994-01-01

A study of the dynamic response of upright circular cylindrical liquid storage tanks containing two different liquids under a rocking base motion with an arbitrary temporal variation is presented. Only rigid tanks were studied. The response quantities examined include the hydrodynamic pressure, the sloshing wave height and associated frequencies, and the base shear and moments. Each of these response quantities is expressed as the sum of the so-called impulsive component and convective component. Unlike the case of tanks containing one liquid, in which the response is controlled by one parameter, the height-to-radius ratio, the response of tanks containing two different liquids is controlled by three parameters: the height-to-radius ratio and the mass density ratio and height ratio of the two liquids. The interrelationship of the responses of the tank-liquid system to rocking and lateral base excitations is established by examining numerical results extensively. It is found that some of the response quantities for a tank-liquid system under a rocking base motion can be determined from the corresponding response quantities for an identical tank under a horizontal base motion. ((orig.))

Generic procedures for medical response during a nuclear or radiological emergency. Emergency preparedness and response

International Nuclear Information System (INIS)

2005-04-01

The aim of this publication is to serve as a practical resource for planning the medical response to a nuclear or radiological emergency. It fulfils in part functions assigned to the IAEA under Article 5.a(ii) of the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (Assistance Convention), namely, to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and available results of research relating to such emergencies. Effective medical response is a necessary component of the overall response to nuclear or radiological (radiation) emergencies. In general, the medical response may represent a difficult challenge for the authorities due to the complexity of the situation, often requiring specialized expertise, and special organizational arrangements and materials. To be effective, adequate planning and preparedness are needed. This manual, if implemented, should help to contribute to coherent international response. The manual provides the practical tools and generic procedures for use by emergency medical personnel during an emergency situation. It also provides guidance to be used at the stage of preparedness for development of medical response capabilities. The manual also addresses mass casualty emergencies resulting from malicious acts involving radioactive material. This part was supported by the Nuclear Security Fund. The manual was developed based on a number of assumptions about national and local capabilities. Therefore, it must be reviewed and revised as part of the planning process to match the potential accidents, threats, local conditions and other unique characteristics of the facility where it may be used

Responsability of nuclear industry

International Nuclear Information System (INIS)

Cadiz Deleito, J.C.

1985-01-01

Since the beginning of nuclear industry, civil responsibility with damages to the public health and properties was a critical problem, because the special conditions of this industry (nuclear accident, damages could be very high but probability of these events is very low). Legal precepts, universally accepted, in the first 60 years for all countries interested in nuclear energy are being revised, then 20 years of experience. The civil responsibility limited is being questioned and indemnities updated. (author)

Corporate Social Responsibility

DEFF Research Database (Denmark)

Liempd, Dennis van; Warming-Rasmussen, Bent; Abild-Nielsen, Jens

2007-01-01

Målet med denne artikel er at klargøre, at der findes forskellige teoretiske tilgange til ansvarlig leverandørstyring og Corporate Social Responsibility (i det følgende kaldt CSR). Endvidere er det målet at belyse, at området er i kraftig udvikling og forventes at få øget betydning for revisor i...... ansvarlig leverandørstyring og CSR. I artiklen konkluderes følgende: - at udviklingen i Corporate Social Responsibility indikerer, at etik er den mest betydende faktor (driver); (jf. afsnit 1)- at etik som primær driver vil betyde, at virksomheden vil gå ud over lovens minimumkrav, og stræbe efter de...

Socially responsible investments in mutual funds

Directory of Open Access Journals (Sweden)

Funaru, M.

2011-01-01

Full Text Available This paper aims to add contribution to the socially responsible investments (from now on called “SRI” research by examining the significance of this type of investment in terms of ethical or financial prior behaviour. Using the sample of European market of socially responsible investments funds, we first explore the SRI market dimension compared to the global data on SRI. We also investigate whether the ethical recognition is more important rather than the financial performance. Applied to the European social responsible investment fund market, the paper investigates the difference between these two aspects of behaviour and underlies the importance of socially responsible investments in promoting a sustainable development.

Responsive turns in Indonesian informal conversation

Directory of Open Access Journals (Sweden)

M.J. van Naerssen

2015-04-01

Full Text Available People have all sorts of expectations about how interlocutors will and should behave linguistically when engaged in a conversation. These conversational norms are usually implicit and are sometimes difficult to master in a language that is new to you. This paper presents a model of different types of responses in informal conversation, illustrated with Indonesian examples. It builds upon the conversation analytic notion of preference; distinguishing preferred – or constructive – responses and dispreferred – or competitive – responses. The model is meant as a tool to cross-linguistically compare response behaviour to gain insight in language specific expectations about interaction in informal conversation.

Complex responses to alkylating agents

International Nuclear Information System (INIS)

Samson, L.D.

2003-01-01

Using Affymetrix oligonucleotide GeneChip analysis, we previously found that, upon exposure to the simple alkylating agent methylmethane sulfonate, the transcript levels for about one third of the Saccharomyces cerevisiae genome (∼2,000 transcripts) are induced or repressed during the first hour or two after exposure. In order to determine whether the responsiveness of these genes has any relevance to the protection of cells against alkylating agents we have undertaken several follow-up studies. First, we explored the specificity of this global transcriptional response to MMS by measuring the global response of S. cerevisiae to a broad range of agents that are known to induce DNA damage. We found that each agent produced a very different mRNA transcript profile, even though the exposure doses produced similar levels of toxicity. We also found that the selection of genes that respond to MMS is highly dependent upon what cell cycle phase the cells are in at the time of exposure. Computational clustering analysis of the dataset derived from a large number of exposures identified several promoter motifs that are likely to control some of the regulons that comprise this large set of genes that are responsive to DNA damaging agents. However, it should be noted that these agents damage cellular components other than DNA, and that the responsiveness of each gene need not be in response to DNA damage per se. We have also begun to study the response of other organisms to alkylating agents, and these include E. coli, cultured mouse and human cells, and mice. Finally, we have developed a high throughput phenotypic screening method to interrogate the role of all non-essential S. cerevisiae genes (about 4,800) in protecting S. cerevisiae against the deleterious effects of alkylating agents; we have termed this analysis 'genomic phenotyping'. This study has uncovered a plethora of new pathways that play a role in the recovery of eukaryotic cells after exposure to toxic

Mycobacteria-specific cytokine responses as correlates of treatment response in active and latent tuberculosis.

Science.gov (United States)

Clifford, Vanessa; Tebruegge, Marc; Zufferey, Christel; Germano, Susie; Forbes, Ben; Cosentino, Lucy; McBryde, Emma; Eisen, Damon; Robins-Browne, Roy; Street, Alan; Denholm, Justin; Curtis, Nigel

2017-08-01

A biomarker indicating successful tuberculosis (TB) therapy would assist in determining appropriate length of treatment. This study aimed to determine changes in mycobacteria-specific antigen-induced cytokine biomarkers in patients receiving therapy for latent or active TB, to identify biomarkers potentially correlating with treatment success. A total of 33 adults with active TB and 36 with latent TB were followed longitudinally over therapy. Whole blood stimulation assays using mycobacteria-specific antigens (CFP-10, ESAT-6, PPD) were done on samples obtained at 0, 1, 3, 6 and 9 months. Cytokine responses (IFN-γ, IL-1ra, IL-2, IL-10, IL-13, IP-10, MIP-1β, and TNF-α) in supernatants were measured by Luminex xMAP immunoassay. In active TB cases, median IL-1ra (with CFP-10 and with PPD stimulation), IP-10 (CFP-10, ESAT-6), MIP-1β (ESAT-6, PPD), and TNF-α (ESAT-6) responses declined significantly over the course of therapy. In latent TB cases, median IL-1ra (CFP-10, ESAT-6, PPD), IL-2 (CFP-10, ESAT-6), and IP-10 (CFP-10, ESAT-6) responses declined significantly. Mycobacteria-specific cytokine responses change significantly over the course of therapy, and their kinetics in active TB differ from those observed in latent TB. In particular, mycobacteria-specific IL-1ra responses are potential correlates of successful therapy in both active and latent TB. Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Personal responsibility or shared responsibility: What is the appropriate role of the law in obesity prevention?

Science.gov (United States)

Brooks, Benjamin

2015-09-01

Sensitive to allegations of "nanny state" paternalism, Australian governments support the doctrine that combating obesity is a matter of personal responsibility. Policy-makers endorse the "holistic" approach to obesity prevention, with a view to managing both sides of the nutritional energy equation. This paradigm allows the food and drinks industry to deflect its contributory responsibility for the epidemic and to avoid more stringent regulatory intervention beyond existing self-regulatory and corporate social responsibility regimes. This article argues that the industry must bear shared responsibility for the extent of the obesity crisis, although it cannot bear sole responsibility It defends the public interest case for more invasive, government-led regulation, reframing the crisis as one of public not individual burdens. Mindful of the political risk associated with unfocused calls for regulatory intervention, it articulates a set of regulatory principles to ensure that the interests of consumers and industry are properly acknowledged prior to further regulatory intervention. Finally, the article clarifies the subject, object and content of possible regulatory initiatives, offering an evaluation of their efficacy, practicality and fairness.

Responsibility, coresponsibility and responsibility to the future in radiation protection and the question of final disposal

International Nuclear Information System (INIS)

Gellermann, R.

2005-01-01

Based on philosophical terms and concepts the responsibility, coresponsibility and responsibility to the future of people working in radiation protection are discussed and some resultant conclusions concerning finals disposal are derived. (orig.)

Partiality of Responsibility: Ethics in Sustainability Consulting

NARCIS (Netherlands)

Earhart, R.S.

2011-01-01

Sustainability, Socially Responsible Investment (SRI) and Corporate Social Responsibility (CSR) are both highly normative fields of professional practice, framed by various narratives: capitalist versus environmentalist, waste versus respect for the planet, consumerism versus responsibility;

Personal factors of moral responsibility in adolescence

Directory of Open Access Journals (Sweden)

Sergey V. Molchanov

2017-12-01

Full Text Available Background. Responsibility as a measure of individual freedom comes only under the condition of freedom of choice and the ability to anticipate and take into account the consequences of acts. Therefore, personal factors play a key role in taking moral responsibility. Scholars have studied the personal bases of responsibility that comprises autonomy, independence, confidence, the locus of control, the motivation to achieve a goal, the level of aspiration. However, the role of the moral self and moral identity in the determination of responsibility is not sufficiently studied. Objective. The objective of the research is to study the relationship between the moral identity of the individual and the willingness to accept moral responsibility in adolescence. Proceeding from the general hypothesis about the essential role of moral identity in adopting and actualising themoral responsibility, two specific hypotheses are articulated, specifying the role of values and moral self-esteem in taking moral responsibility. Design. An empirical study of adolescents aged 13–17 years was conducted. Subjects are students of educational institutions of general education in Moscow (a total of 314 subjects. The study poses the challenges of studying the readiness to accept moral responsibility by adolescents in the situation of a moral dilemma, the connection of the moral and value orientation of adolescents and the willingness to accept moral responsibility, the connection of self-esteem of moral qualities and the readiness of adolescents to accept moral responsibility. The methodology for assessing moral responsibility in the situation of solving the moral dilemma «Moral Situations from Real Life» (MORS, a modified version of M. Rokich’s method for evaluating value orientations, the method of structured moral self-esteem (A.I. Podolsky, P. Heymans, O.A. Karabanova are used. Conclusion. The results revealed the influence of the participants’ moral dilemma

The path to corporate responsibility.

Science.gov (United States)

Zadek, Simon

2004-12-01

Nike's tagline,"Just do it," is an inspirational call to action for the millions who wear the company's athletic gear. But in terms of corporate responsibility, Nike didn't always follow its own advice. In the 1990s, protesters railed against sweatshop conditions at some of its overseas suppliers and made Nike the global poster child for corporate ethical fecklessness. The intense pressure that activists exerted on the athletic apparel giant forced it to take a long, hard look at corporate responsibility--sooner than it might have otherwise. In this article, Simon Zadek, CEO of the UK-based institute AccountAbility, describes the bumpy route Nike has traveled to get to a better ethical place, one that cultivates and champions responsible business practices. Organizations learn in unique ways, Zadek contends, but they inevitably pass through five stages of corporate responsibility, from defensive ("It's not our fault") to compliance ("We'll do only what we have to") to managerial ("It's the business") to strategic ("It gives us a competitive edge") and, finally, to civil ("We need to make sure everybody does it"). He details Nike's arduous trek through these stages-from the company's initial defensive stance, when accusations about working conditions arose, all the way to its engagement today in the international debate about business's role in society and in public policy. As he outlines this evolution, Zadek offers valuable insights to executives grappling with the challenge of managing responsible business practices. Beyond just getting their own houses in order, the author argues, companies need to stay abreast of the public's evolving ideas about corporate roles and responsibilities. Organizations that do both will engage in what he calls"civil learning".

Impaired reward responsiveness in schizophrenia.

Science.gov (United States)

Taylor, Nicholas; Hollis, Jeffrey P; Corcoran, Sarah; Gross, Robin; Cuthbert, Bruce; Swails, Lisette W; Duncan, Erica

2018-03-08

Anhedonia is a core negative symptom of schizophrenia. Schizophrenia patients report largely intact pleasure in consuming rewards, but have impairments in generating motivated behavior to pursue rewards, and show reduced fMRI activation of the reward pathway during presentation of rewarded stimuli. A computer based task measuring the development of a response bias in favor of rewarded stimuli permits assessment of reward-induced motivation. We hypothesized that subjects with schizophrenia would be impaired on this task. 58 schizophrenia subjects (SCZ) and 52 healthy controls (CON) were studied with a signal detection task to assess reward responsiveness. In multiple trials over three blocks subjects were asked to correctly identify two stimuli that were paired with unequal chance of monetary reward. The critical outcome variable was response bias, the development of a greater percent correct identification of the stimulus that was rewarded more often. An ANOVA on response bias with Block as a repeated-measures factor and Diagnosis as a between-group factor indicated that SCZ subjects achieved a lower bias to rewarded stimuli than CON subjects (F(1,105)=8.82, p=0.004, η 2 =0.078). Post hoc tests indicated that SCZ subjects had significantly impaired bias in Block 1 (p=0.002) and Block 2 (p=0.05), indicating that SCZ were slower to achieve normal levels of bias during the session. SCZ subjects were slower to develop response bias to rewarded stimuli than CON subjects. This finding is consonant with the hypothesis that people with schizophrenia have a blunted capacity to modify behavior in response to reward. Copyright © 2018. Published by Elsevier B.V.

The finite element response matrix method

International Nuclear Information System (INIS)

Nakata, H.; Martin, W.R.

1983-02-01

A new technique is developed with an alternative formulation of the response matrix method implemented with the finite element scheme. Two types of response matrices are generated from the Galerkin solution to the weak form of the diffusion equation subject to an arbitrary current and source. The piecewise polynomials are defined in two levels, the first for the local (assembly) calculations and the second for the global (core) response matrix calculations. This finite element response matrix technique was tested in two 2-dimensional test problems, 2D-IAEA benchmark problem and Biblis benchmark problem, with satisfatory results. The computational time, whereas the current code is not extensively optimized, is of the same order of the well estabilished coarse mesh codes. Furthermore, the application of the finite element technique in an alternative formulation of response matrix method permits the method to easily incorporate additional capabilities such as treatment of spatially dependent cross-sections, arbitrary geometrical configurations, and high heterogeneous assemblies. (Author) [pt

Optimal Number of Questionnaire Response Categories

Directory of Open Access Journals (Sweden)

W. Paul Jones

2013-05-01

Full Text Available Two multi-instrument investigations in a university clinic/lab provided an opportunity to explore the impact of reducing the number of response alternatives in a scale measuring vocational personality traits. In a simulation study, a standard computer-based administration provided a numeric scale for each item ranging from 0 to 10. The tests were then rescored to simulate the effect of only three choices. For the follow-up study, two versions of the scale were created, one with two response options and the other with six response options, and were randomly assigned to participants. Typical relationships were evident between the vocational personality traits and scores on standard measures of core personality traits with negligible impact from reducing the number of response alternatives. Neither the ability of the participants nor the self-reported distress had a measurable impact on the utility of the results with the reduction in response alternatives.

The Dangers of Dispersal of Responsibilities

Directory of Open Access Journals (Sweden)

Adriana Schiopoiu Burlea

2017-05-01

Full Text Available Taking into account that it is in the nature of the modern corporation that risks are distributed over several agents, we discuss in this paper the organisational behaviour as it results from such dispersal of responsibilities for both the principal and the agent. We explore the hypothesis that dispersal of responsibilities could be the result or a cause of a lack of consensus between the principal and the agent. Our findings suggest that a dispersal of responsibilities has a negative impact on the principal-agent relationship and that it represents a foundation for theoretical and empirical approaches to organisational behaviour. We find that agent perceptions of a dispersal of responsibilities are linked to his/her resistance to the principal’s interests, but this relationship is deeper than was suggested by previous research. However, if the sharing of responsibilities does not run parallel to that, we may have as a result what we call an agency problem.

African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses?

Directory of Open Access Journals (Sweden)

Benoit Stijlemans

2017-05-01

Full Text Available African trypanosomosis is a debilitating disease of great medical and socioeconomical importance. It is caused by strictly extracellular protozoan parasites capable of infecting all vertebrate classes including human, livestock, and game animals. To survive within their mammalian host, trypanosomes have evolved efficient immune escape mechanisms and manipulate the entire host immune response, including the humoral response. This report provides an overview of how trypanosomes initially trigger and subsequently undermine the development of an effective host antibody response. Indeed, results available to date obtained in both natural and experimental infection models show that trypanosomes impair homeostatic B-cell lymphopoiesis, B-cell maturation and survival and B-cell memory development. Data on B-cell dysfunctioning in correlation with parasite virulence and trypanosome-mediated inflammation will be discussed, as well as the impact of trypanosomosis on heterologous vaccine efficacy and diagnosis. Therefore, new strategies aiming at enhancing vaccination efficacy could benefit from a combination of (i early parasite diagnosis, (ii anti-trypanosome (drugs treatment, and (iii anti-inflammatory treatment that collectively might allow B-cell recovery and improve vaccination.

32 CFR 636.1 - Responsibilities.

Science.gov (United States)

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Responsibilities. 636.1 Section 636.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Fort Stewart, Georgia § 636.1 Responsibilities. In addition to the...

Social responsibility of corporations

Directory of Open Access Journals (Sweden)

Babić Jovan

2007-01-01

Full Text Available The issue at stake in the article is corporate social responsibility. There are two rival theories regarding this issue. According to the classical theory managers are responsible to owners (stockholders and their obligation is to pursue the goal of maximizing the profit. According to the other, stakeholder theory, the interests of all corporate stakeholders, all those affected by business, not only stockholders, must be taken in consideration. In the paper these two theories are subject of thorough ethical analysis.

Radioactive materials transportation emergency response plan

International Nuclear Information System (INIS)

Karmali, N.

1987-05-01

Ontario Hydro transports radioactive material between its nuclear facilities, Atomic Energy of Canada Limited at Chalk River Laboratories and Radiochemical Company in Kanata, on a regular basis. Ontario Hydro also occasionally transports to Whiteshell Laboratories, Hydro-Quebec and New Brunswick Electric Power Commission. Although there are stringent packaging and procedural requirements for these shipments, Ontario Hydro has developed a Radioactive Materials Transportation Emergency Response Plan in the event that there is an accident. The Transportation Emergency Response plan is based on six concepts: 1) the Province id divided into three response areas with each station (Pickering, Darlington, Bruce) having identified response areas; 2) response is activated via a toll-free number. A shift supervisor at Pickering will answer the call, determine the hazards involved from the central shipment log and provide on-line advice to the emergency worker. At the same time he will notify the nearest Ontario Hydro area office to provide initial corporate response, and will request the nearest nuclear station to provide response assistance; 3) all stations have capability in terms of trained personnel and equipment to respond to an accident; 4) all Ontario Hydro shipments are logged with Pickering NGS. Present capability is based on computerized logging with the computer located in the shift office at Pickering to allow quick access to information on the shipment; 5) there is a three tier structure for emergency public information. The local Area Manager is the first Ontario Hydro person at the scene of the accident. The responding facility technical spokesperson is the second line of Corporate presence and the Ontario Hydro Corporate spokesperson is notified in case the accident is a media event; and 6) Ontario Hydro will respond to non-Hydro shipments of radioactive materials in terms of providing assistance, guidance and capability. However, the shipper is responsible

Generation of human auditory steady-state responses (SSRs). II: Addition of responses to individual stimuli.

Science.gov (United States)

Santarelli, R; Maurizi, M; Conti, G; Ottaviani, F; Paludetti, G; Pettorossi, V E

1995-03-01

In order to investigate the generation of the 40 Hz steady-state response (SSR), auditory potentials evoked by clicks were recorded in 16 healthy subjects in two stimulating conditions. Firstly, repetition rates of 7.9 and 40 Hz were used to obtain individual middle latency responses (MLRs) and 40 Hz-SSRs, respectively. In the second condition, eight click trains were presented at a 40 Hz repetition rate and an inter-train interval of 126 ms. We extracted from the whole train response: (1) the response-segment taking place after the last click of the train (last click response, LCR), (2) a modified LCR (mLCR) obtained by clearing the LCR from the amplitude enhancement due to the overlapping of the responses to the clicks preceding the last within the stimulus train. In comparison to MLRs, the most relevant feature of the evoked activity following the last click of the train (LCRs, mLCRs) was the appearance in the 50-110 ms latency range of one (in 11 subjects) or two (in 2 subjects) additional positive-negative deflections having the same periodicity as that of MLR waves. The grand average (GA) of the 40 Hz-SSRs was compared with three predictions synthesized by superimposing: (1) the GA of MLRs, (2) the GA of LCRs, (3) the GA of mLCRs. Both the MLR and mLCR predictions reproduced the recorded signal in amplitude while the LCR prediction amplitude resulted almost twice that of the 40 Hz-SSR. With regard to the phase, the MLR, LCR and mLCR closely predicted the recorded signal. Our findings confirm the effectiveness of the linear addition mechanism in the generation of the 40 Hz-SSR. However the responses to individual stimuli within the 40 Hz-SSR differ from MLRs because of additional periodic activity. These results suggest that phenomena related to the resonant frequency of the activated system may play a role in the mechanisms which interact to generate the 40 Hz-SSR.

Seismic Safety Margins Research Program. Phase 1. Project V. Structural sub-system response: subsystem response review

International Nuclear Information System (INIS)

Fogelquist, J.; Kaul, M.K.; Koppe, R.; Tagart, S.W. Jr.; Thailer, H.; Uffer, R.

1980-03-01

This project is directed toward a portion of the Seismic Safety Margins Research Program which includes one link in the seismic methodology chain. The link addressed here is the structural subsystem dynamic response which consists of those components and systems whose behavior is often determined decoupled from the major structural response. Typically the mathematical model utilized for the major structural response will include only the mass effects of the subsystem and the main model is used to produce the support motion inputs for subsystem seismic qualification. The main questions addressed in this report have to do with the seismic response uncertainty of safety-related components or equipment whose seismic qualification is performed by (a) analysis, (b) tests, or (c) combinations of analysis and tests, and where the seismic input is assumed to have no uncertainty

Emotion response coherence: A dual-process perspective

NARCIS (Netherlands)

Evers, C.; Hopp, H.; Gross, J.J.; Fischer, A.H.; Manstead, A.S.R.; Mauss, I.B.

2014-01-01

Emotions are widely thought to involve coordinated responses across multiple responses (e.g., experiential, behavioral, and physiological). However, empirical support for this general "response coherence" postulate is inconsistent. The present research takes a dual-process perspective, suggesting

Emotion response coherence : a dual-process perspective

NARCIS (Netherlands)

Evers, Catharine; Hopp, Henrik; Gross, James J; Fischer, Agneta H; Manstead, Antony S R; Mauss, Iris B

Emotions are widely thought to involve coordinated responses across multiple responses (e.g., experiential, behavioral, and physiological). However, empirical support for this general "response coherence" postulate is inconsistent. The present research takes a dual-process perspective, suggesting

Emergency response preparedness analysis for radioactive materials transportation

International Nuclear Information System (INIS)

Parentela, E.M.; Burli, S.S.; Sathisan, S.K.; Vodrazka, W.C.

1994-01-01

This paper evaluates the emergency response capabilities of first responders, specifically fire services, within the state of Nevada. It addresses issues relating to the available emergency responders such as general capabilities, jurisdictions, and response times. Graphical displays of the response units and attribute tables were created using GIS ARC/INFO. These coverages, plus the existing Census Bureau TIGER Files and highway network for the state of Nevada, were utilized to determine approximate service areas of each response unit, population density served by each response unit, population density served by each response unit and the areas that can be served by a response unit for 3, 5, 10, and 30 minutes response times. Results of the analysis enabled identification of the critical areas along the proposed highway route corridor

Cognitive Reflection, Decision Biases, and Response Times.

Science.gov (United States)

Alós-Ferrer, Carlos; Garagnani, Michele; Hügelschäfer, Sabine

2016-01-01

We present novel evidence on response times and personality traits in standard questions from the decision-making literature where responses are relatively slow (medians around half a minute or above). To this end, we measured response times in a number of incentivized, framed items (decisions from description) including the Cognitive Reflection Test, two additional questions following the same logic, and a number of classic questions used to study decision biases in probability judgments (base-rate neglect, the conjunction fallacy, and the ratio bias). All questions create a conflict between an intuitive process and more deliberative thinking. For each item, we then created a non-conflict version by either making the intuitive impulse correct (resulting in an alignment question), shutting it down (creating a neutral question), or making it dominant (creating a heuristic question). For CRT questions, the differences in response times are as predicted by dual-process theories, with alignment and heuristic variants leading to faster responses and neutral questions to slower responses than the original, conflict questions. For decision biases (where responses are slower), evidence is mixed. To explore the possible influence of personality factors on both choices and response times, we used standard personality scales including the Rational-Experiential Inventory and the Big Five, and used them as controls in regression analysis.

Risk and responsibility: a complex and evolving relationship.

Science.gov (United States)

Kermisch, Céline

2012-03-01

This paper analyses the nature of the relationship between risk and responsibility. Since neither the concept of risk nor the concept of responsibility has an unequivocal definition, it is obvious that there is no single interpretation of their relationship. After introducing the different meanings of responsibility used in this paper, we analyse four conceptions of risk. This allows us to make their link with responsibility explicit and to determine if a shift in the connection between risk and responsibility can be outlined. (1) In the engineer's paradigm, the quantitative conception of risk does not include any concept of responsibility. Their relationship is indirect, the locus of responsibility being risk management. (2) In Mary Douglas' cultural theory, risks are constructed through the responsibilities they engage. (3) Rayner and (4) Wolff go further by integrating forms of responsibility in the definition of risk itself. Analysis of these four frameworks shows that the concepts of risk and responsibility are increasingly intertwined. This tendency is reinforced by increasing public awareness and a call for the integration of a moral dimension in risk management. Therefore, we suggest that a form of virtue-responsibility should also be integrated in the concept of risk. © Springer Science+Business Media B.V. 2010

Vertical Footbridge Vibrations: The Response Spectrum Methodology

DEFF Research Database (Denmark)

Georgakis, Christos; Ingólfsson, Einar Thór

2008-01-01

In this paper, a novel, accurate and readily codifiable methodology for the prediction of vertical footbridge response is presented. The methodology is based on the well-established response spectrum approach used in the majority of the world’s current seismic design codes of practice. The concept...... of a universally applicable reference response spectrum is introduced, from which the pedestrian-induced vertical response of any footbridge may be determined, based on a defined “event” and the probability of occurrence of that event. A series of Monte Carlo simulations are undertaken for the development...... period is introduced and its implication on the calculation of footbridge response is discussed. Finally, a brief comparison is made between the theoretically predicted pedestrian-induced vertical response of an 80m long RC footbridge (as an example) and actual field measurements. The comparison shows...

Emergency planning and response preparedness in Slovenia

International Nuclear Information System (INIS)

Martincic, R.; Frlin-Lubi, A.; Usenicnik, B.

2000-01-01

Disasters do occur and so do nuclear or radiological accidents. Experience has shown that advance emergency response preparedness is essential in order to mitigate the consequences of an accident. In Slovenia, the Civil Protection Organization is the responsible authority for emergency preparedness and response to any kind of disasters. The Krko Nuclear Power Plant is the only nuclear power plant in Slovenia. To date the plant has operated safely and no serious incidents have been recorded. Slovenia nevertheless, maintains a high level of emergency preparedness, which is reflected in the area of prevention and safety and in the area of emergency response preparedness. The emergency management system for nuclear emergencies is incorporated into an overall preparedness and response system. The paper presents an overview of nuclear or radiological emergency response preparedness in Slovenia and its harmonization with the international guidelines. (author)

Photovoltaic spectral responsivity measurements

Energy Technology Data Exchange (ETDEWEB)

Emery, K.; Dunlavy, D.; Field, H.; Moriarty, T. [National Renewable Energy Lab., Golden, CO (United States)

1998-09-01

This paper discusses the various elemental random and nonrandom error sources in typical spectral responsivity measurement systems. The authors focus specifically on the filter and grating monochrometer-based spectral responsivity measurement systems used by the Photovoltaic (PV) performance characterization team at NREL. A variety of subtle measurement errors can occur that arise from a finite photo-current response time, bandwidth of the monochromatic light, waveform of the monochromatic light, and spatial uniformity of the monochromatic and bias lights; the errors depend on the light source, PV technology, and measurement system. The quantum efficiency can be a function of he voltage bias, light bias level, and, for some structures, the spectral content of the bias light or location on the PV device. This paper compares the advantages and problems associated with semiconductor-detector-based calibrations and pyroelectric-detector-based calibrations. Different current-to-voltage conversion and ac photo-current detection strategies employed at NREL are compared and contrasted.

7 CFR 621.24 - NRCS responsibility.

Science.gov (United States)

2010-01-01

... AGRICULTURE WATER RESOURCES RIVER BASIN INVESTIGATIONS AND SURVEYS Floodplain Management Assistance § 621.24 NRCS responsibility. NRCS is responsible for providing leadership for scheduling and implementing the...

The finite element response Matrix method

International Nuclear Information System (INIS)

Nakata, H.; Martin, W.R.

1983-01-01

A new method for global reactor core calculations is described. This method is based on a unique formulation of the response matrix method, implemented with a higher order finite element method. The unique aspects of this approach are twofold. First, there are two levels to the overall calculational scheme: the local or assembly level and the global or core level. Second, the response matrix scheme, which is formulated at both levels, consists of two separate response matrices rather than one response matrix as is generally the case. These separate response matrices are seen to be quite beneficial for the criticality eigenvalue calculation, because they are independent of k /SUB eff/. The response matrices are generated from a Galerkin finite element solution to the weak form of the diffusion equation, subject to an arbitrary incoming current and an arbitrary distributed source. Calculational results are reported for two test problems, the two-dimensional International Atomic Energy Agency benchmark problem and a two-dimensional pressurized water reactor test problem (Biblis reactor), and they compare well with standard coarse mesh methods with respect to accuracy and efficiency. Moreover, the accuracy (and capability) is comparable to fine mesh for a fraction of the computational cost. Extension of the method to treat heterogeneous assemblies and spatial depletion effects is discussed

Pharmacogenetics of antidepressant response: An update

Directory of Open Access Journals (Sweden)

Drago Antonio

2009-04-01

Full Text Available Abstract The past few decades have witnessed much progress in the field of pharmacogenetics. The identification of the genetic background that regulates the antidepressant response has benefited from these advances. This review focuses on the pharmacogenetics of the antidepressant response through the analysis and discussion of the most compelling evidence in this line of research. Online databases (Medline and PsycINFO have been searched and the most replicated association findings relating to the genetics of the antidepressant response have been reported and discussed. Some replicated findings in the literature have suggested the serotonin transporter promoter (5-HTTLPR, serotonin receptor 1A (HTR1A, serotonin receptor 2A (HTR2A, brain derived neurotrophic factor (BDNF, corticotropin releasing hormone receptor 1 (CRHR1 and FK506 binding protein 5 (FKBP5 as putative regulators of the antidepressant response. A high rate of failure of replication has also been reported. Pharmacogenetics will hopefully provide the basis for personalised antidepressant treatment that is able to maximise the probability of a good response and to minimise side effects; however, this goal is not achievable at the moment. The extent of the validity of the replicated findings and the reasons for the poor results obtained from studies of the pharmacogenetics of the antidepressant response are discussed.

Responsible innovation in the private sector : Foreword

NARCIS (Netherlands)

Scholten, V.E.; Blok, V.

2015-01-01

Responsible Innovation is an emerging concept concerning the governance of socio-ethical aspects of research and innovation practices. Von Schomberg for instance defines responsible innovation as a ‘transparent, interactive process by which societal actors and innovators become mutually responsive

Foreword: Responsible Innovation in the Private Sector

NARCIS (Netherlands)

Scholten, V.; Blok, V.

2015-01-01

Responsible Innovation is an emerging concept concerning the governance of socio-ethical aspects of research and innovation practices. Von Schomberg for instance defines responsible innovation as a ‘transparent, interactive process by which societal actors and innovators become mutually responsive

Plant response to biotic stress: Is there a common epigenetic response during plant-pathogenic and symbiotic interactions?

Science.gov (United States)

Zogli, Prince; Libault, Marc

2017-10-01

Plants constantly interact with pathogenic and symbiotic microorganisms. Recent studies have revealed several regulatory mechanisms controlling these interactions. Among them, the plant defense system is activated not only in response to pathogenic, but also in response to symbiotic microbes. Interestingly, shortly after symbiotic microbial recognition, the plant defense system is suppressed to promote plant infection by symbionts. Research studies have demonstrated the influence of the plant epigenome in modulating both pathogenic and symbiotic plant-microbe interactions, thereby influencing plant survival, adaptation and evolution of the plant response to microbial infections. It is however unclear if plant pathogenic and symbiotic responses share similar epigenomic profiles or if epigenomic changes differentially regulate plant-microbe symbiosis and pathogenesis. In this mini-review, we provide an update of the current knowledge of epigenomic control on plant immune responses and symbiosis, with a special attention being paid to knowledge gap and potential strategies to fill-in the missing links. Copyright © 2017 Elsevier B.V. All rights reserved.

Cellular responses to environmental DNA damage

Energy Technology Data Exchange (ETDEWEB)

1994-08-01

This volume contains the proceedings of the conference entitled Cellular Responses to Environmental DNA Damage held in Banff,Alberta December 1--6, 1991. The conference addresses various aspects of DNA repair in sessions titled DNA repair; Basic Mechanisms; Lesions; Systems; Inducible Responses; Mutagenesis; Human Population Response Heterogeneity; Intragenomic DNA Repair Heterogeneity; DNA Repair Gene Cloning; Aging; Human Genetic Disease; and Carcinogenesis. Individual papers are represented as abstracts of about one page in length.

Experimental data and dose-response models

International Nuclear Information System (INIS)

Ullrich, R.L.

1985-01-01

Dose-response relationships for radiation carcinogenesis have been of interest to biologists, modelers, and statisticians for many years. Despite his interest there are few instances in which there are sufficient experimental data to allow the fitting of various dose-response models. In those experimental systems for which data are available the dose-response curves for tumor induction for the various systems cannot be described by a single model. Dose-response models which have been observed following acute exposures to gamma rays include threshold, quadratic, and linear models. Data on sex, age, and environmental influences of dose suggest a strong role of host factors on the dose response. With decreasing dose rate the effectiveness of gamma ray irradiation tends to decrease in essentially every instance. In those cases in which the high dose rate dose response could be described by a quadratic model, the effect of dose rate is consistent with predictions based on radiation effects on the induction of initial events. Whether the underlying reasons for the observed dose-rate effect is a result of effects on the induction of initial events or is due to effects on the subsequent steps in the carcinogenic process is unknown. Information on the dose response for tumor induction for high LET (linear energy transfer) radiations such as neutrons is even more limited. The observed dose and dose rate data for tumor induction following neutron exposure are complex and do not appear to be consistent with predictions based on models for the induction of initial events

Attributions of Responsibility and Blame for Procrastination Behavior.

Science.gov (United States)

Rahimi, Sonia; Hall, Nathan C; Pychyl, Timothy A

2016-01-01

The present study examined the relationship between procrastination, delay, blameworthiness, and moral responsibility. Undergraduate students (N = 240) were provided two scenarios in which the reason for inaction (procrastination, delay), the target (self, other), and the outcome (positive, negative) were manipulated, and students were asked to rate the moral responsibility and blameworthiness of the agent. Results indicated that individuals who procrastinated were seen as more morally responsible and blameworthy than those who experienced delay. More specifically, after a negative outcome, procrastination was associated with more moral responsibility, whereas delay was associated with less moral responsibility. After a positive outcome, individuals perceived procrastination as deserving of less moral responsibility, and delays as associated with more moral responsibility. Finally, a three-way interaction showed that participants rated procrastination that resulted in failure as deserving of responsibility when engaged in by others as opposed to oneself.

Providing Reliability Services through Demand Response: A Prelimnary Evaluation of the Demand Response Capabilities of Alcoa Inc.

Energy Technology Data Exchange (ETDEWEB)

Starke, Michael R [ORNL; Kirby, Brendan J [ORNL; Kueck, John D [ORNL; Todd, Duane [Alcoa; Caulfield, Michael [Alcoa; Helms, Brian [Alcoa

2009-02-01

Demand response is the largest underutilized reliability resource in North America. Historic demand response programs have focused on reducing overall electricity consumption (increasing efficiency) and shaving peaks but have not typically been used for immediate reliability response. Many of these programs have been successful but demand response remains a limited resource. The Federal Energy Regulatory Commission (FERC) report, 'Assessment of Demand Response and Advanced Metering' (FERC 2006) found that only five percent of customers are on some form of demand response program. Collectively they represent an estimated 37,000 MW of response potential. These programs reduce overall energy consumption, lower green house gas emissions by allowing fossil fuel generators to operate at increased efficiency and reduce stress on the power system during periods of peak loading. As the country continues to restructure energy markets with sophisticated marginal cost models that attempt to minimize total energy costs, the ability of demand response to create meaningful shifts in the supply and demand equations is critical to creating a sustainable and balanced economic response to energy issues. Restructured energy market prices are set by the cost of the next incremental unit of energy, so that as additional generation is brought into the market, the cost for the entire market increases. The benefit of demand response is that it reduces overall demand and shifts the entire market to a lower pricing level. This can be very effective in mitigating price volatility or scarcity pricing as the power system responds to changing demand schedules, loss of large generators, or loss of transmission. As a global producer of alumina, primary aluminum, and fabricated aluminum products, Alcoa Inc., has the capability to provide demand response services through its manufacturing facilities and uniquely through its aluminum smelting facilities. For a typical aluminum smelter

Manipulation of the metabolic response in clinical practice

DEFF Research Database (Denmark)

Kehlet, H

2000-01-01

morbidity. Effective afferent neural blockade with continuous epidural local anesthetic techniques inhibits a major part of the endocrine metabolic response, leading to improved protein economy but without important effects on inflammatory or immunologic responses. In contrast, pain treatment with other...... modalities such as nonsteroidal antiinflammatory drugs (NSAIDs) and opioids has only a small inhibitory effect on endocrine metabolic responses. Preoperative high-dose glucocorticoid therapy provides additional pain relief and improves pulmonary function, but it reduces the inflammatory response (acute......-phase proteins, cytokines, hyperthermia) and immune function. Minimally invasive surgery leaves the endocrine metabolic responses largely unaltered but reduces the inflammatory response and immune suppression. Thus several techniques are available to modify the stress responses in elective surgery patients...

Spectral entropy and haemodynamic response to surgery during ...

African Journals Online (AJOL)

Adele

Spectral entropy and haemodynamic response to surgery during sevoflurane anaesthesia. Introduction. Apart from somatic responses, surgery also evokes autonomic responses, including haemodynamic responses. Spectral entropy has been validated as a means to monitor the hypnotic state during sevoflurane ...

Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses1

Science.gov (United States)

Allam, Atef; Swiecki, Melissa; Vermi, William; Ashwell, Jonathan D.; Colonna, Marco

2014-01-01

The role of the tumor necrosis factor family member CD70 in adaptive T cell responses has been intensively studied but its function in innate responses is still under investigation. Here we show that CD70 inhibits the early innate response to murine cytomegalovirus (MCMV) but is essential for the optimal generation of virus-specific CD8 T cells. CD70-/- mice reacted to MCMV infection with a robust type I interferon and proinflammatory cytokine response. This response was sufficient for initial control of MCMV, although at later time points, CD70-/- mice became more susceptible to MCMV infection. The heightened cytokine response during the early phase of MCMV infection in CD70-/- mice was paralleled by a reduction in regulatory T cells (Treg). Treg from naïve CD70-/- mice were not as efficient at suppressing T cell proliferation compared to Treg from naïve WT mice and depletion of Treg during MCMV infection in Foxp3-DTR mice or in WT mice recapitulated the phenotype observed in CD70-/- mice. Our study demonstrates that while CD70 is required for the activation of the antiviral adaptive response, it has a regulatory role in early cytokine responses to viruses such as MCMV, possibly through maintenance of Treg survival and function. PMID:24913981

Mechanical Response of Thermoelectric Materials

Energy Technology Data Exchange (ETDEWEB)

Wereszczak, Andrew A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Case, Eldon D. [Michigan State Univ., East Lansing, MI (United States)

2015-05-01

A sufficient mechanical response of thermoelectric materials (TEMats) to structural loadings is a prerequisite to the exploitation of any candidate TEMat's thermoelectric efficiency. If a TEMat is mechanically damaged or cracks from service-induced stresses, then its thermal and electrical functions can be compromised or even cease. Semiconductor TEMats tend to be quite brittle and have a high coefficient of thermal expansion; therefore, they can be quite susceptible to mechanical failure when subjected to operational thermal gradients. Because of this, sufficient mechanical response (vis-a-vis, mechanical properties) of any candidate TEMat must be achieved and sustained in the context of the service-induced stress state to which it is subjected. This report provides an overview of the mechanical responses of state-of-the-art TEMats; discusses the relevant properties that are associated with those responses and their measurement; and describes important, nonequilibrium phenomena that further complicate their use in thermoelectric devices. For reference purposes, the report also includes several appendixes that list published data on elastic properties and strengths of a variety of TEMats.

28 CFR 105.25 - Authorized employer's responsibilities.

Science.gov (United States)

2010-07-01

... BACKGROUND CHECKS Private Security Officer Employment § 105.25 Authorized employer's responsibilities. An authorized employer is responsible for: (a) Executing and providing to the appropriate state agency the... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Authorized employer's responsibilities...

Distinct Trajectories of Cortisol Response to Prolonged Acute Stress Are Linked to Affective Responses and Hippocampal Gray Matter Volume in Healthy Females.

Science.gov (United States)

Admon, Roee; Treadway, Michael T; Valeri, Linda; Mehta, Malavika; Douglas, Samuel; Pizzagalli, Diego A

2017-08-16

The development of robust laboratory procedures for acute stress induction over the last decades has greatly advanced our understanding of stress responses in humans and their underlying neurobiological mechanisms. Nevertheless, attempts to uncover linear relationships among endocrine, neural, and affective responses to stress have generally yielded inconsistent results. Here, 79 healthy females completed a well established laboratory procedure of acute stress induction that was modified to prolong its effect. Endocrinological and subjective affect assessments revealed stress-induced increases in cortisol release and negative affect that persisted 65 and 100 min after stress onset, respectively, confirming a relatively prolonged acute stress induction. Applying latent class linear mixed modeling on individuals' patterns of cortisol responses identified three distinct trajectories of cortisol response: the hyper-response ( n = 10), moderate-response ( n = 21), and mild-response ( n = 48) groups. Notably, whereas all three groups exhibited a significant stress-induced increase in cortisol release and negative affect, the hyper-response and mild-response groups both reported more negative affect relative to the moderate-response group. Structural MRI revealed no group differences in hippocampal and amygdala volumes, yet a continuous measure of cortisol response (area under the curve) showed that high and low levels of stress-induced cortisol release were associated with less hippocampal gray matter volume compared with moderate cortisol release. Together, these results suggest that distinct trajectories of cortisol response to prolonged acute stress among healthy females may not be captured by conventional linear analyses; instead, quadratic relations may better describe links between cortisol response to stress and affective responses, as well as hippocampal structural variability. SIGNIFICANCE STATEMENT Despite substantial research, it is unclear whether and how

Towards accurate emergency response behavior

International Nuclear Information System (INIS)

Sargent, T.O.

1981-01-01

Nuclear reactor operator emergency response behavior has persisted as a training problem through lack of information. The industry needs an accurate definition of operator behavior in adverse stress conditions, and training methods which will produce the desired behavior. Newly assembled information from fifty years of research into human behavior in both high and low stress provides a more accurate definition of appropriate operator response, and supports training methods which will produce the needed control room behavior. The research indicates that operator response in emergencies is divided into two modes, conditioned behavior and knowledge based behavior. Methods which assure accurate conditioned behavior, and provide for the recovery of knowledge based behavior, are described in detail

Plant Responses to Nanoparticle Stress

Directory of Open Access Journals (Sweden)

Zahed Hossain

2015-11-01

Full Text Available With the rapid advancement in nanotechnology, release of nanoscale materials into the environment is inevitable. Such contamination may negatively influence the functioning of the ecosystems. Many manufactured nanoparticles (NPs contain heavy metals, which can cause soil and water contamination. Proteomic techniques have contributed substantially in understanding the molecular mechanisms of plant responses against various stresses by providing a link between gene expression and cell metabolism. As the coding regions of genome are responsible for plant adaptation to adverse conditions, protein signatures provide insights into the phytotoxicity of NPs at proteome level. This review summarizes the recent contributions of plant proteomic research to elaborate the complex molecular pathways of plant response to NPs stress.

Behavioural responses to human-induced environmental change.

Science.gov (United States)

Tuomainen, Ulla; Candolin, Ulrika

2011-08-01

The initial response of individuals to human-induced environmental change is often behavioural. This can improve the performance of individuals under sudden, large-scale perturbations and maintain viable populations. The response can also give additional time for genetic changes to arise and, hence, facilitate adaptation to new conditions. On the other hand, maladaptive responses, which reduce individual fitness, may occur when individuals encounter conditions that the population has not experienced during its evolutionary history, which can decrease population viability. A growing number of studies find human disturbances to induce behavioural responses, both directly and by altering factors that influence fitness. Common causes of behavioural responses are changes in the transmission of information, the concentration of endocrine disrupters, the availability of resources, the possibility of dispersal, and the abundance of interacting species. Frequent responses are alterations in habitat choice, movements, foraging, social behaviour and reproductive behaviour. Behavioural responses depend on the genetically determined reaction norm of the individuals, which evolves over generations. Populations first respond with individual behavioural plasticity, whereafter changes may arise through innovations and the social transmission of behavioural patterns within and across generations, and, finally, by evolution of the behavioural response over generations. Only a restricted number of species show behavioural adaptations that make them thrive in severely disturbed environments. Hence, rapid human-induced disturbances often decrease the diversity of native species, while facilitating the spread of invasive species with highly plastic behaviours. Consequently, behavioural responses to human-induced environmental change can have profound effects on the distribution, adaptation, speciation and extinction of populations and, hence, on biodiversity. A better understanding of

Strategies for Demand Response in Commercial Buildings

Energy Technology Data Exchange (ETDEWEB)

Watson, David S.; Kiliccote, Sila; Motegi, Naoya; Piette, Mary Ann

2006-06-20

This paper describes strategies that can be used in commercial buildings to temporarily reduce electric load in response to electric grid emergencies in which supplies are limited or in response to high prices that would be incurred if these strategies were not employed. The demand response strategies discussed herein are based on the results of three years of automated demand response field tests in which 28 commercial facilities with an occupied area totaling over 11 million ft{sup 2} were tested. Although the demand response events in the field tests were initiated remotely and performed automatically, the strategies used could also be initiated by on-site building operators and performed manually, if desired. While energy efficiency measures can be used during normal building operations, demand response measures are transient; they are employed to produce a temporary reduction in demand. Demand response strategies achieve reductions in electric demand by temporarily reducing the level of service in facilities. Heating ventilating and air conditioning (HVAC) and lighting are the systems most commonly adjusted for demand response in commercial buildings. The goal of demand response strategies is to meet the electric shed savings targets while minimizing any negative impacts on the occupants of the buildings or the processes that they perform. Occupant complaints were minimal in the field tests. In some cases, ''reductions'' in service level actually improved occupant comfort or productivity. In other cases, permanent improvements in efficiency were discovered through the planning and implementation of ''temporary'' demand response strategies. The DR strategies that are available to a given facility are based on factors such as the type of HVAC, lighting and energy management and control systems (EMCS) installed at the site.

STRESS RESPONSE STUDIES USING ANIMAL MODELS

Science.gov (United States)

This presentation will provide the evidence that ozone exposure in animal models induce neuroendocrine stress response and this stress response modulates lung injury and inflammation through adrenergic and glucocorticoid receptors.

Responsible tax as corporate social responsibility: the case of multinational enterprises and effective tax in India

NARCIS (Netherlands)

Muller, A.; Kolk, A.

2015-01-01

Anecdotal evidence often suggests that multinational enterprises (MNEs) operating in developing countries "exploit their multinationality" to avoid paying taxes to host governments. This article explores the concept of "responsible tax" as a corporate social responsibility (CSR) issue for MNEs,

Enhancing 'Whole-of-Government' Response to Biological Events in Korea: Able Response 2014.

Science.gov (United States)

Tak, Sangwoo; Jareb, Anton; Choi, Suon; Sikes, Marvin; Choi, Yeon Hwa; Boo, Hyeong-Wook

2018-01-01

Since 2011, the Republic of Korea (ROK) and United States (U.S.) have been collaborating to conduct inter- and intra-governmental exercises to jointly respond to biological events in Korea. These exercises highlight U.S. interest in increasing its global biosurveillance capability and the ROK's interest in improving cooperation among ministries to respond to crises. With Able Response (AR) exercises, the ROK and U.S. have improved coordination among US and ROK government and defense agencies responding to potential bio-threats and identified additional areas on which to apply refinements in policies and practices. In 2014, the AR exercise employed a Biosurveillance Portal (BSP) to facilitate more effective communication among participating agencies and countries including Australia. In the present paper, we seek to provide a comprehensive assessment of the AR 2014 (AR14) exercise and make recommendations for future improvements. Incorporating a more realistic response in future scenarios by integrating a tactical response episode in the exercise is recommended.

Land Transport Emergency Response Technology Report

International Nuclear Information System (INIS)

DOTSON, LORI J.; PIERCE, JIM D.

2003-01-01

Sandia National Laboratories was tasked by the Japan Nuclear Cycle Development Institute (JNC) to provide assistance in developing an emergency response plan for radioactive material transportation activities. Those tasks included compiling radioactive materials (RAM) transportation accident data FR-om the open literature and databases, investigating emergency response plans for radioactive materials transport in the United States, and developing specific recommendations for the JNC' nuclear material transport emergency response plan, based on information gathered during the first two tasks. These recommendations include developing a RAM database, a public transparency Internet website, an emergency response inFR-astructure designed specifically for transportation needs, and a clear set of directives to provide authority in the case of transportation accidents or incidents involving RAM

Spill response : an exercise in teamwork

International Nuclear Information System (INIS)

Anon.

1998-01-01

An offshore oil spill response exercise was conducted at Hibernia to demonstrate to the Canada-Newfoundland Offshore Petroleum Board the emergency response capabilities that are in place in the event of large offshore spills. The Canadian Coast Guard, Eastern Canada Response Corporation Ltd., Hibernia, Husky Oil Operations Ltd., Jeanne d'Arc Basin Operators Group and the Terra Nova Project team participated in the exercise. The exercise was a success in that it demonstrated that the emergency response teams have the capability of containing and recovering large and small offshore oil spills. The two systems that were tested during the exercise were the large wide-swath boom system and a smaller side-sweep system. Two supply vessels worked in tandem. 11 figs

Responsibility for scientific misconduct in collaborative papers.

Science.gov (United States)

Helgesson, Gert; Eriksson, Stefan

2017-12-08

This paper concerns the responsibility of co-authors in cases of scientific misconduct. Arguments in research integrity guidelines and in the bioethics literature concerning authorship responsibilities are discussed. It is argued that it is unreasonable to claim that for every case where a research paper is found to be fraudulent, each author is morally responsible for all aspects of that paper, or that one particular author has such a responsibility. It is further argued that it is more constructive to specify what task responsibilities come with different roles in a project and describe what kinds of situations or events call for some kind of action, and what the appropriate actions might be.

Scintillation response of organic and inorganic scintillators

CERN Document Server

Papadopoulos, L M

1999-01-01

A method to evaluate the scintillation response of organic and inorganic scintillators to different heavy ionizing particles is suggested. A function describing the rate of the energy consumed as fluorescence emission is derived, i.e., the differential response with respect to time. This function is then integrated for each ion and scintillator (anthracene, stilbene and CsI(Tl)) to determine scintillation response. The resulting scintillation responses are compared to the previously reported measured responses. Agreement to within 2.5% is observed when these data are normalized to each other. In addition, conclusions regarding the quenching parameter kB dependence on the type of the particle and the computed values of kB for certain ions are included. (author)

Considerations Regarding the Environmental Responsibility and Taxation

Directory of Open Access Journals (Sweden)

Florian-Marcel Nuta

2012-02-01

Full Text Available The public policy tool of taxation may generate discouraging effects upon the economicagents – consumers or producers – but also could beused as incentives. High environmental taxationcould generate crowding effect in terms of responsibility. Sometimes a very sophisticated system ofenvironmental taxation is the basis for a highly regulated business environment and conformity butwith a lack of real responsible citizenship. We aretrying to see if the impact of taxation uponresponsibility is real and can affect the motivation for environmental responsible citizenship. Themain findings are related to the impact of regulating power of environmental taxes. Also there isevident the interest of entrepreneurs in environmentally responsible behavior and the less informationabout the benefits of responsible citizenship.

Emergency preparedness and response

International Nuclear Information System (INIS)

Griffiths, M.

1996-01-01

After the Chernobyl accident, it became painfully obvious to the international community that there was an urgent need to establish a system for the coordination of international disaster assistance. It became the task of the United Nations Office for Disaster Relief (UNDRO) to develop such a system. The former UNDRO was subsumed into the Department of Humanitarian Affairs (DHA), established in January 1992 on the basis of UN General Assembly Resolution 46/182 adopted in December 1991, and the disaster relief system presently found in DHA is a further evolution of the system established by UNDRO. One particular importance in relation to nuclear accidents is the fact that UNDRO and the International Atomic Energy Agency (IAEA) signed a Memorandum of Understanding defining their respective responsibilities and the need for cooperation in case of accidents involving the unintentional release of nuclear radiation. In essence, the MOU makes it clear that the responsibilities of the IAEA, in connection with accidents at Nuclear Power Plants, related to the technical and radiological aspects, in particular to accident prevention, to the on-site preparedness, and to remedial measures within the 30-km zone outside the NPP. DHA's responsibilities, on the other hand, relate to the general preparedness and the rescue efforts outside the 30 km zone. In this respect, the preparedness and emergency response system is no different from the system employed in any other type of sudden-onset emergency

RESULTS, RESPONSIBILITY, FAULT AND CONTROL

Directory of Open Access Journals (Sweden)

Evgeniy Stoyanov

2016-09-01

Full Text Available The paper focuses on the responsibility arising from the registered financial results. The analysis of this responsibility presupposes its evaluation and determination of the role of fault in the formation of negative results. The search for efficiency in this whole process is justified by the understanding of the mechanisms that regulate the behavior of economic actors.

48 CFR 452.236-77 - Emergency Response.

Science.gov (United States)

2010-10-01

... contracts: Emergency Response (NOV 1996) (a) Contractor's Responsibility for Fire Fighting. (1) The... emergency work (anticipated to be restricted to fire fighting). An equitable adjustment for the temporary... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Emergency Response. 452...

Response spectrum analysis for multi-supported subsystems

International Nuclear Information System (INIS)

Reed, J.W.

1983-01-01

A methodology was developed to analyze multi-supported subsystems (e.g., piping systems) for seismic or other dynamic forces using response spectrum input. Currently, subsystems which are supported at more than one location in a nuclear power plant building are analyzed either by the time-history method or by response spectrum procedures, where spectra which envelop all support locations are used. The former procedure is exceedingly expensive, while the latter procedure is inexpensive but very conservative. Improved analysis procedures are currently being developed which are either coupled- or uncoupled-system approaches. For the coupled-system approach, response feedback between the subsystem and building system is included. For the uncoupled-system approach, feedback is neglected; however, either time history or response spectrum methods can be used. The methodology developed for analyzing multi-supported subsystems is based on the assumption that the building response and the subsystem response are uncoupled. This is the same assumption implicitly made by analysts who design singly-supported subsystems using floor response spectrum input. This approach implies that there is no response feedback between the primary building system and the subsystem, which is generally found to be conservative. The methodology developed for multi-supported subsystems makes this same assumption and thus should produce results with the same ease and degree of accuracy as results obtained for singly-supported subsystems. (orig./HP)

Corporate legal responsibility: A levinasian perspective

OpenAIRE

Soares, Conceição

2008-01-01

In this article I will look into Corporate Legal Responsibility taking into account Levinas’s notion of infinite responsibility, as well as his understanding of ethical language. My account of Levinas’s philosophy will show that it challenges – breaking down – deeply entrenched distinctions in the dominant strands of moral philosophy, within which the theory of individual responsibility is embedded, such as between:(1) duty to others on the one hand and supererogation on the other; (2) perfec...

Responsive web design with jQuery

CERN Document Server

Carlos, Gilberto

2013-01-01

Responsive Web Design with jQuery follows a standard tutorial-based approach, covering various aspects of responsive web design by building a comprehensive website.""Responsive Web Design with jQuery"" is aimed at web designers who are interested in building device-agnostic websites. You should have a grasp of standard HTML, CSS, and JavaScript development, and have a familiarity with graphic design. Some exposure to jQuery and HTML5 will be beneficial but isn't essential.

Assessment of Mobile Accident Response Capability

International Nuclear Information System (INIS)

1983-03-01

This report presents the results of a DOE-sponsored assessment of nuclear accident response resources. It identifies the mobile resources that could be required to respond to different types of nuclear accidents including major ones like TMI-2, identifies the resources currently available and makes recommendations for the design and construction of additional mobile accident response resources to supplement those already in existence. This project is referred to as the Mobile Accident Response Capability (MARC) program

Attributions of Responsibility and Blame for Procrastination Behavior

Directory of Open Access Journals (Sweden)

Sonia Rahimi

2016-08-01

Full Text Available The present study examined the relationship between procrastination, delay, blameworthiness, and moral responsibility. Undergraduate students (N = 240 were provided two scenarios in which the reason for inaction (procrastination, delay, the target (self, other, and the outcome (positive, negative were manipulated, and students were asked to rate the moral responsibility and blameworthiness of the agent. Results indicated that individuals who procrastinated were seen as more morally responsible and blameworthy than those who otherwise experienced delay. More specifically, after a negative outcome, procrastination was associated with more moral responsibility, whereas delay was associated with less moral responsibility. After a positive outcome, individuals perceived procrastination as deserving of less moral responsibility, and delays as associated with more moral responsibility. Finally, a three-way interaction showed that participants rated procrastination that resulted in failure as deserving of responsibility when engaged in by others as opposed to oneself.

Group Effects on Individual Attitudes Toward Social Responsibility.

Science.gov (United States)

Secchi, Davide; Bui, Hong T M

2018-01-01

This study uses a quasi-experimental design to investigate what happens to individual socially responsible attitudes when they are exposed to group dynamics. Findings show that group engagement increases individual attitudes toward social responsibility. We also found that individuals with low attitudes toward social responsibility are more likely to change their opinions when group members show more positive attitudes toward social responsibility. Conversely, individuals with high attitudes do not change much, independent of group characteristics. To better analyze the effect of group dynamics, the study proposes to split social responsibility into relative and absolute components. Findings show that relative social responsibility is correlated with but different from absolute social responsibility although the latter is more susceptible than the former to group dynamics.

Interpersonal competencies: Responsiveness, technique, and training in psychotherapy.

Science.gov (United States)

Hatcher, Robert L

2015-11-01

Professional practice in psychology is anchored in interpersonal or relational skills. These skills are essential to successful interactions with clients and their families, students, and colleagues. Expertise in these skills is desired and expected for the practicing psychologist. An important but little-studied aspect of interpersonal skills is what Stiles and colleagues (Stiles, Honos-Webb, & Surko, 1998; Stiles, 2009, 2013) have called appropriate responsiveness. In treatment relationships, appropriate responsiveness is the therapist's ability to achieve optimal benefit for the client by adjusting responses to the current state of the client and the interaction. This article was designed to clarify this aspect of responsiveness, showing its links to empathy, illustrating how responsiveness has been detected in controlled clinical trials, discussing how educators and supervisors have worked to enhance students' responsiveness, and considering how appropriate responsiveness has been assessed. The article also discusses the development of skills underlying appropriate responsiveness and the role of stable differences in talent in training of professional psychologists. Notwithstanding other pessimistic reports on psychologists' expertise, demonstrable expertise may exist in the effective, responsive use of these skills in treatment settings. Appropriate responsiveness may be a variety of executive functioning, organizing and guiding the use of many specific competencies. As such it may be a metacompetency, with implications for the design of competency schemes. Key to all of these considerations is the distinction between therapeutic techniques and their responsive use, which involves astute judgment as to when and how to utilize these responses to best effect in the treatment situation. (c) 2015 APA, all rights reserved).

NaI(Tl) response functions

International Nuclear Information System (INIS)

Vega C, H. R.; Ortiz R, J. M.; Benites R, J. L.; De Leon M, H. A.

2015-09-01

The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: 56 Mn, 24 Na, and 28 Al. (Author)

Study on radiation-responsive epigenomes

International Nuclear Information System (INIS)

Kim, Jin Hong; Chung, Byung Yeop; Lee, Seung Sik; Moon, Yu Ran; Lee, Min Hee; Kim, Ji Hong

2011-01-01

The purpose of this project is development of world-class headspring techniques of biological science for application of plant genomes/epigenomes through study on radiation- responsive epigenomes and improvement of the national competitiveness in the field of fundamental technology for biological science and industry. Research scope includes 1) Investigation of radiation-responsive epigenomes and elucidation of their relation with phenotypes, 2) Elucidation of interaction and transcription control of epigenomes and epigenetic regulators using ionizing radiation (IR), 3) Investigation of epigenome-mediated traits in plant development, differentiation and antioxidant defense using IR, and 4) Development of application techniques of radiation-responsive epigenomes for eco-monitoring and molecular breeding. Main results are as follow: Setup of conditions for chromatin immunoprecipitation in irradiated plants: investigation of aberrations in DNA methylation after treatment with different IR: elucidation of responses of epigenetic regulators to gamma rays (GR): investigation of aberrations in GR-responsive epigenetic regulators at different developmental stages: elucidation of interactive aberrations of epigenomes and epigenetic regulators after treatment of GR: comparison of functional genomes after treatment of GR or H 2 O 2 : elucidation of relation of epigenomes with GR-induced delay in senescence: elucidation of relation of epigenomes with GR-induced aberrations in pigment metabolism: comparison of antioxidant defense in epigenetic mutants: investigation of senescence-associated changes in epigenomes: investigation of senescence-associated changes in epigenetic regulators: comparison of aberrations in epigenomes at different dose of GR for mutation

Study on radiation-responsive epigenomes

Energy Technology Data Exchange (ETDEWEB)

Kim, Jin Hong; Chung, Byung Yeop; Lee, Seung Sik; Moon, Yu Ran; Lee, Min Hee; Kim, Ji Hong [KAERI, Daejeon (Korea, Republic of)

2011-01-15

The purpose of this project is development of world-class headspring techniques of biological science for application of plant genomes/epigenomes through study on radiation- responsive epigenomes and improvement of the national competitiveness in the field of fundamental technology for biological science and industry. Research scope includes 1) Investigation of radiation-responsive epigenomes and elucidation of their relation with phenotypes, 2) Elucidation of interaction and transcription control of epigenomes and epigenetic regulators using ionizing radiation (IR), 3) Investigation of epigenome-mediated traits in plant development, differentiation and antioxidant defense using IR, and 4) Development of application techniques of radiation-responsive epigenomes for eco-monitoring and molecular breeding. Main results are as follow: Setup of conditions for chromatin immunoprecipitation in irradiated plants: investigation of aberrations in DNA methylation after treatment with different IR: elucidation of responses of epigenetic regulators to gamma rays (GR): investigation of aberrations in GR-responsive epigenetic regulators at different developmental stages: elucidation of interactive aberrations of epigenomes and epigenetic regulators after treatment of GR: comparison of functional genomes after treatment of GR or H{sub 2}O{sub 2}: elucidation of relation of epigenomes with GR-induced delay in senescence: elucidation of relation of epigenomes with GR-induced aberrations in pigment metabolism: comparison of antioxidant defense in epigenetic mutants: investigation of senescence-associated changes in epigenomes: investigation of senescence-associated changes in epigenetic regulators: comparison of aberrations in epigenomes at different dose of GR for mutation.

NaI(Tl) response functions

Energy Technology Data Exchange (ETDEWEB)

Vega C, H. R.; Ortiz R, J. M. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Benites R, J. L. [Centro Estatal de Cancerologia de Nayarit, Calz. de la Cruz 118 Sur, Tepic, Nayarit (Mexico); De Leon M, H. A., E-mail: fermineutron@yahoo.com.mx [Instituto Tecnologico de Aguascalientes, Av. Adolfo Lopez Mateos 1801 Ote., 20155 Aguascalientes, Ags. (Mexico)

2015-09-15

The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: {sup 56}Mn, {sup 24}Na, and {sup 28}Al. (Author)

Associations Between Paternal Responsiveness and Stress Responsiveness in the Biparental California Mouse, Peromyscus californicus

OpenAIRE

Chauke, Miyetani

2012-01-01

The mechanistic basis of paternal behavior in mammals is poorly understood. Assuming there are parallels between the factors mediating maternal and paternal behavior, it can be expected that the onset of paternal behavior is facilitated by reductions in stress responsiveness, as occurs in females of several mammalian species. This dissertation describes studies investigating the role of stress responsiveness in the expression of paternal behavior in biparental, monogamous California mice (Per...

48 CFR 242.771-3 - Responsibilities.

Science.gov (United States)

2010-10-01

....771-3 Responsibilities. (a) The cognizant administrative contracting officer (ACO) or corporate ACO... (OUSD(AT&L)DDR&E), is responsible for establishing a regular method for communication— (1) From DoD to...

Dissociating the influence of response selection and task anticipation on corticospinal suppression during response preparation.

Science.gov (United States)

Duque, Julie; Labruna, Ludovica; Cazares, Christian; Ivry, Richard B

2014-12-01

Motor behavior requires selecting between potential actions. The role of inhibition in response selection has frequently been examined in tasks in which participants are engaged in some advance preparation prior to the presentation of an imperative signal. Under such conditions, inhibition could be related to processes associated with response selection, or to more general inhibitory processes that are engaged in high states of anticipation. In Experiment 1, we manipulated the degree of anticipatory preparation. Participants performed a choice reaction time task that required choosing between a movement of the left or right index finger, and used transcranial magnetic stimulation (TMS) to elicit motor evoked potentials (MEPs) in the left hand agonist. In high anticipation blocks, a non-informative cue (e.g., fixation marker) preceded the imperative; in low anticipation blocks, there was no cue and participants were required to divide their attention between two tasks to further reduce anticipation. MEPs were substantially reduced before the imperative signal in high anticipation blocks. In contrast, in low anticipation blocks, MEPs remained unchanged before the imperative signal but showed a marked suppression right after the onset of the imperative. This effect occurred regardless of whether the imperative had signalled a left or right hand response. After this initial inhibition, left MEPs increased when the left hand was selected and remained suppressed when the right hand was selected. We obtained similar results in Experiment 2 except that the persistent left MEP suppression when the left hand was not selected was attenuated when the alternative response involved a non-homologous effector (right foot). These results indicate that, even in the absence of an anticipatory period, inhibitory mechanisms are engaged during response selection, possibly to prevent the occurrence of premature and inappropriate responses during a competitive selection process. Copyright

Dissociating the Influence of Response Selection and Task Anticipation on Corticospinal Suppression During Response Preparation

Science.gov (United States)

Duque, Julie; Labruna, Ludovica; Cazares, Christian; Ivry, Richard B.

2014-01-01

Motor behavior requires selecting between potential actions. The role of inhibition in response selection has frequently been examined in tasks in which participants are engaged in some advance preparation prior to the presentation of an imperative signal. Under such conditions, inhibition could be related to processes associated with response selection, or to more general inhibitory processes that are engaged in high states of anticipation. In Experiment 1, we manipulated the degree of anticipatory preparation. Participants performed a choice reaction time task that required choosing between a movement of the left or right index finger, and used transcranial magnetic stimulation (TMS) to elicit motor evoked potentials (MEPs) in the left hand agonist. In high anticipation blocks, a non-informative cue (e.g., fixation marker) preceded the imperative; in low anticipation blocks, there was no cue and participants were required to divide their attention between two tasks to further reduce anticipation. MEPs were substantially reduced before the imperative signal in high anticipation blocks. In contrast, in low anticipation blocks, MEPs remained unchanged before the imperative signal but showed a marked suppression right after the onset of the imperative. This effect occurred regardless of whether the imperative had signaled a left or right hand response. After this initial inhibition, left MEPs increased when the left hand was selected and remained suppressed when the right hand was selected. We obtained similar results in Experiment 2 except that the persistent left MEP suppression when the left hand was not selected was attenuated when the alternative response involved a non-homologous effector (right foot). These results indicate that, even in the absence of an anticipatory period, inhibitory mechanisms are engaged during response selection, possibly to prevent the occurrence of premature and inappropriate responses during a competitive selection process. PMID

45 CFR 400.115 - Establishing legal responsibility.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Establishing legal responsibility. 400.115 Section... Child Welfare Services § 400.115 Establishing legal responsibility. (a) A State must ensure that legal responsibility is established, including legal custody and/or guardianship, as appropriate, in accordance with...

Social responsibility as modern conception of business

OpenAIRE

Vorona, E.

2010-01-01

Research of social responsibility is conducted in the context of theory of socialization of the economic systems. Approaches are considered to essence of concept «Social responsibility». The positive consequences of realization of social responsibility and its connection are certain with a competitiveness and efficiency

Responsibility and care in the collaborative economy

DEFF Research Database (Denmark)

Dredge, Dianne

2017-01-01

concepts such as ethics, responsibility and moral action in the collaborative economy. The traditional approach is for governments to adopt universal rules to determine who is responsible for what consequences and to prescribe remedies so that actors can ‘earn’ the claim of being responsible. However...

40 CFR 1065.845 - Response factor determination.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Response factor determination. 1065... POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Testing With Oxygenated Fuels § 1065.845 Response factor... each FID analyzer's alcohol/carbonyl response factor (such as RF MeOH) after FID optimization to...

Gastrointestinal immune responses in HIV infected subjects

Directory of Open Access Journals (Sweden)

LRR Castello-Branco

1996-06-01

Full Text Available The gut associated lymphoid tissue is responsible for specific responses to intestinal antigens. During HIV infection, mucosal immune deficiency may account for the gastrointestinal infections. In this review we describe the humoral and cellular mucosal immune responses in normal and HIV-infected subjects.

Magnetic Field Response Measurement Acquisition System

Science.gov (United States)

Woodard, Stanley E.; Taylor,Bryant D.; Shams, Qamar A.; Fox, Robert L.

2007-01-01

This paper presents a measurement acquisition method that alleviates many shortcomings of traditional measurement systems. The shortcomings are a finite number of measurement channels, weight penalty associated with measurements, electrical arcing, wire degradations due to wear or chemical decay and the logistics needed to add new sensors. Wire degradation has resulted in aircraft fatalities and critical space launches being delayed. The key to this method is the use of sensors designed as passive inductor-capacitor circuits that produce magnetic field responses. The response attributes correspond to states of physical properties for which the sensors measure. Power is wirelessly provided to the sensing element by using Faraday induction. A radio frequency antenna produces a time-varying magnetic field used to power the sensor and receive the magnetic field response of the sensor. An interrogation system for discerning changes in the sensor response frequency, resistance and amplitude has been developed and is presented herein. Multiple sensors can be interrogated using this method. The method eliminates the need for a data acquisition channel dedicated to each sensor. The method does not require the sensors to be near the acquisition hardware. Methods of developing magnetic field response sensors and the influence of key parameters on measurement acquisition are discussed. Examples of magnetic field response sensors and the respective measurement characterizations are presented. Implementation of this method on an aerospace system is discussed.

CORPORATE SOCIAL RESPONSIBILITY OF COMPANIES IN BOSNIA AND HERZEGOVINA

OpenAIRE

Čavalić, Admir; Bećirović, Damir

2017-01-01

The concept of corporate social responsibility implies that the company has far more responsibilities that overcome its basic economic responsibility. Corporate social responsibility is the imperative of modern business and one of the prerequisites for achieving competitive advantage. Thus, in order to be socially responsible, it is important for a company to demonstrate a certain level of responsibility towards its stakeholders. Historically, the concept of social responsibility has been the...

Step response and frequency response of an air conditioning system

NARCIS (Netherlands)

Crommelin, R.D.; Jackman, P.J.

1978-01-01

A system of induction units of an existing air conditioning system has been analyzed with respect to its dynamic properties. Time constants were calculated and measured by analogue models. Comparison with measurements at the installation itself showed a reasonable agreement. Frequency responses were

48 CFR 1845.502 - Contractor responsibility.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor responsibility. 1845.502 Section 1845.502 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Contractors 1845.502 Contractor responsibility. ...

Is man responsible for global warming?; L'homme est-il responsable du rechauffement climatique?

Energy Technology Data Exchange (ETDEWEB)

Legendre, A

2009-07-01

According to politicians, ecologists and mass media, it is now certain that with our CO{sub 2} emissions, we are all responsible for a major global warming to come with dramatic consequences. But, is this affirmation indisputable? Are we all responsible for the rise of sea level and the summer thawing of the arctic ice shelf? Is this expected global warming without precedent? And is CO{sub 2}, necessary for life, the cause of our misfortune? The answers commonly claimed are maybe more complex in reality and the climate question more subtle than it looks like. This book tries to decode the wheels of the climate machine and the share of human responsibility in climate change. (J.S.)

The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia

NARCIS (Netherlands)

Renckens, Rosemarijn; Roelofs, Joris J. T. H.; Knapp, Sylvia; de Vos, Alex F.; Florquin, Sandrine; van der Poll, Tom

2006-01-01

BACKGROUND: Acinetobacter baumannii is an emerging pathogen in nosocomial pneumonia. Trauma and postsurgical patients display a profound acute-phase protein response and are susceptible to pneumonia. METHODS: To study the way in which the acute-phase response induced by sterile tissue injury

Corporate Social Responsibility in the Angolan Oil Industry

OpenAIRE

Arne Wiig

2005-01-01

What are the responsibility of oil companies in resource rich countries? Do they take these responsibilities? Based on a utilitarian perspective and theories of the resource curse, we discuss the oil companies' corporate social responsibility (CSR) when a resource rich country such as Angola lacks accountable public institutions. We also analyse the type of responsibility oil companies take and factors driving corporate social responsibility. From undertaking a survey among oil service firms ...

Personal Responsibility in Oral Health: Ethical Considerations

DEFF Research Database (Denmark)

Albertsen, Andreas

2012-01-01

Personal responsibility is a powerful idea supported by many values central to West European thought. On the conceptual level personal responsibility is a complex notion. It is important to separate the concept of being responsible for a given state of affairs from the concept of holding people r...

49 CFR 214.311 - Responsibility of employers.

Science.gov (United States)

2010-10-01

... Responsibility of employers. (a) Each employer is responsible for the understanding and compliance by its employees with its rules and the requirements of this part. (b) Each employer shall guarantee each employee... 49 Transportation 4 2010-10-01 2010-10-01 false Responsibility of employers. 214.311 Section 214...

24 CFR 7.16 - Responsibilities of employees.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Responsibilities of employees. 7.16... Responsibilities of employees. All employees of the Department are responsible for: (a) Being informed as to the..., females, persons with disabilities, veterans and others of diverse characteristics in the workforce, and...

Biofilms and host response - helpful or harmful

DEFF Research Database (Denmark)

Moser, Claus; Pedersen, Hannah Trøstrup; Lerche, Christian Johann

2017-01-01

infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response...

Linux Incident Response Volatile Data Analysis Framework

Science.gov (United States)

McFadden, Matthew

2013-01-01

Cyber incident response is an emphasized subject area in cybersecurity in information technology with increased need for the protection of data. Due to ongoing threats, cybersecurity imposes many challenges and requires new investigative response techniques. In this study a Linux Incident Response Framework is designed for collecting volatile data…

Corporate responsibility – det handler om redelighed

DEFF Research Database (Denmark)

Thomsen, Steen

2009-01-01

Virksomhedsansvar – corporate responsibility – kan blive et fællesbegreb for selskabsledelse, bæredygtighed og corporate social responsibility, der hver især drejer sig om forskellige former for bæredygtighed – finansiel, social og miljømæssig......Virksomhedsansvar – corporate responsibility – kan blive et fællesbegreb for selskabsledelse, bæredygtighed og corporate social responsibility, der hver især drejer sig om forskellige former for bæredygtighed – finansiel, social og miljømæssig...

Pitch-Responsive Cortical Regions in Congenital Amusia.

Science.gov (United States)

Norman-Haignere, Sam V; Albouy, Philippe; Caclin, Anne; McDermott, Josh H; Kanwisher, Nancy G; Tillmann, Barbara

2016-03-09

Congenital amusia is a lifelong deficit in music perception thought to reflect an underlying impairment in the perception and memory of pitch. The neural basis of amusic impairments is actively debated. Some prior studies have suggested that amusia stems from impaired connectivity between auditory and frontal cortex. However, it remains possible that impairments in pitch coding within auditory cortex also contribute to the disorder, in part because prior studies have not measured responses from the cortical regions most implicated in pitch perception in normal individuals. We addressed this question by measuring fMRI responses in 11 subjects with amusia and 11 age- and education-matched controls to a stimulus contrast that reliably identifies pitch-responsive regions in normal individuals: harmonic tones versus frequency-matched noise. Our findings demonstrate that amusic individuals with a substantial pitch perception deficit exhibit clusters of pitch-responsive voxels that are comparable in extent, selectivity, and anatomical location to those of control participants. We discuss possible explanations for why amusics might be impaired at perceiving pitch relations despite exhibiting normal fMRI responses to pitch in their auditory cortex: (1) individual neurons within the pitch-responsive region might exhibit abnormal tuning or temporal coding not detectable with fMRI, (2) anatomical tracts that link pitch-responsive regions to other brain areas (e.g., frontal cortex) might be altered, and (3) cortical regions outside of pitch-responsive cortex might be abnormal. The ability to identify pitch-responsive regions in individual amusic subjects will make it possible to ask more precise questions about their role in amusia in future work. Copyright © 2016 the authors 0270-6474/16/362986-09$15.00/0.

Responsiveness of the Prosthetic Esthetic Scale

DEFF Research Database (Denmark)

Øzhayat, Esben Boeskov

2017-01-01

Objectives The aim of the study was to evaluate the responsiveness of the Prosthetic Esthetic Index (PEI) in a population who received prosthetic replacements. Materials and methods Fifty-seven patients who received prosthetic replacement of at least one tooth by means of fixed or removable...... prosthesis were professionally esthetically evaluated using the PEI and the Dental Aesthetic Index (DAI) before and after treatment. The participants further evaluated their oral esthetics using the Oral Health Impact Profile Aesthetic (OHIP-Aes) and Orofacial Esthetic Index (OES). Responsiveness......-Aes and OES scores. The PEI was more consistent in responsiveness than the DAI. Conclusions The PEI shows sufficient responsiveness for use in longitudinal studies and for use as a follow-up measure in clinical practice. Clinical relevance The PEI can in a standardized manner monitor and document esthetic...

T-cell response in human leishmaniasis

DEFF Research Database (Denmark)

Kharazmi, A; Kemp, K; Ismail, A

1999-01-01

In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered...... from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4......+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans....

Abiotic stressors and stress responses

DEFF Research Database (Denmark)

Sulmon, Cecile; Van Baaren, Joan; Cabello-Hurtado, Francisco

2015-01-01

Abstract Organisms are regularly subjected to abiotic stressors related to increasing anthropogenic activities, including chemicals and climatic changes that induce major stresses. Based on various key taxa involved in ecosystem functioning (photosynthetic microorganisms, plants, invertebrates), we...... review how organisms respond and adapt to chemical- and temperature-induced stresses from molecular to population level. Using field-realistic studies, our integrative analysis aims to compare i) how molecular and physiological mechanisms related to protection, repair and energy allocation can impact...... life history traits of stressed organisms, and ii) to what extent trait responses influence individual and population responses. Common response mechanisms are evident at molecular and cellular scales but become rather difficult to define at higher levels due to evolutionary distance and environmental...

Corporate Social Responsibility in Aviation

Science.gov (United States)

Phillips, Edwin D.

2006-01-01

The dialog within aviation management education regarding ethics is incomplete without a discussion of corporate social responsibility (CSR). CSR research requires discussion involving: (a) the current emphasis on CSR in business in general and aviation specifically; (b) business and educational theory that provide a basis for aviation companies to engage in socially responsible actions; (c) techniques used by aviation and aerospace companies to fulfill this responsibility; and (d) a glimpse of teaching approaches used in university aviation management classes. The summary of this research suggests educators explain CSR theory and practice to students in industry and collegiate aviation management programs. Doing so extends the discussion of ethical behavior and matches the current high level of interest and activity within the aviation industry toward CSR.

Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees

Science.gov (United States)

Faughn, Carley; Marrus, Natasha; Shuman, Jeremy; Ross, Stephen R.; Constantino, John N.; Pruett, John R., Jr.; Povinelli, Daniel J.

2015-01-01

Comparative studies of social responsiveness, a core impairment in autism spectrum disorder (ASD), will enhance our understanding of typical and atypical social behavior. We previously reported a quantitative, cross-species (human-chimpanzee) social responsiveness measure, which included the development of the Chimpanzee Social Responsiveness…

Detecting Careless Responses to Self-Reported Questionnaires

Science.gov (United States)

Kountur, Ronny

2016-01-01

Problem Statement: The use of self-report questionnaires may lead to biases such as careless responses that distort the research outcomes. Early detection of careless responses in self-report questionnaires may reduce error, but little guidance exists in the literature regarding techniques for detecting such careless or random responses in…

Sources of perceived responsiveness in family relationships.

Science.gov (United States)

Cook, William L; Dezangré, Marie; De Mol, Jan

2018-05-10

Perceived responsiveness has become one of the most important constructs in the relationship sciences. It is central to the development of a secure attachment style, the experience of social support, an internal locus of control, and the sense of control in close relationships. Conversely, an unresponsive environment is associated with learned helplessness and depression. Viewed through the lens of the social relations model (SRM), perceived responsiveness in family relationships could have multiple sources: the perceiver; the target or partner; the perceiver-target relationship; and the family group. This study used the SRM to determine the relative importance of these sources of perceived responsiveness in the relationships of 207 two-parent two-child families. Characteristics of the perceiver and the target each accounted for about 25% of the systematic variance in perceived responsiveness, whereas the perceiver-target relationship accounted for approximately 48%. At the individual level of analysis, reciprocity of perceived responsiveness was pervasive in the family relationships of the two children. Regardless of age, young people who generally perceived others as responsive were generally perceived by others as responsive. At the dyadic level of analysis, reciprocity was present in two dyads: mother-father and older child-younger child. Reliable target variances support the view that perceived responsiveness is not just "inside the head" of the perceiver, and reciprocity correlations suggest potentially useful systemic interventions. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Radiation emergency response in Illinois, Alabama, and Texas

International Nuclear Information System (INIS)

Larsen, D.K.; Chester, R.O.

1978-03-01

The objective of this study was to examine state radiation emergency response and to locate any areas of emergency planning in need of improvement. This report briefly presents a summary of laws and defining documents governing radiation emergency response, describes the existing and projected need for such response, and presents the authors' analyses of the evolution of state response plans and their application to radiation incidents. Three states' programs are discussed in detail: Illinois, Alabama, and Texas. These states were selected because they have quite different emergency-response programs. Therefore, these state programs provide a wide variety of approaches to state radiation emergency response

Tourists’ Environmentally Responsible Behavior in Response to Climate Change and Tourist Experiences in Nature-Based Tourism

Directory of Open Access Journals (Sweden)

Ju Hyoung Han

2016-07-01

Full Text Available Nature-based tourism destinations—locations in which economic viability and environmental responsibility are sought—are sensitive to climate change and its effects on important environmental components of the tourism areas. To meet the dual roles, it is important for destination marketers and resources managers to provide quality experiences for tourists and to induce tourists’ environmentally responsible behavior in such destinations. This study documents the importance of perceptions toward climate change and tourist experiences in determining tourists’ environmentally responsible behavior while enjoying holidays at nature-based tourism destinations in Jeju Island, South Korea. Two hundred and eleven Korean and 204 Chinese tourists marked dominant tourist arrivals to the island, and responded to the survey questionnaire. Results showed that perceptions toward climate change and tourist experiences affect Korean tourists’ environmentally responsible behavior intentions, whereas tourist experiences—not perceptions toward climate change—only significantly affect Chinese tourists’ behavior intention. In a nature-based tourism context under the pressure of climate change and adverse environmental effects as consequences of tourism activities, resources managers and destination marketers need to develop environmental campaigns or informative tourist programs to formulate environmentally responsible behavior as well as to increase tourist quality experiences among domestic and international tourists.

Correlation of EPO resistance with oxidative stress response and inflammatory response in patients with maintenance hemodialysis

Directory of Open Access Journals (Sweden)

Xiao-Hui Yan

2017-08-01

Full Text Available Objective: To study the correlation of erythropoietin (EPO resistance with oxidative stress response and inflammatory response in patients with maintenance hemodialysis. Methods: A total of 184 patients with end-stage renal disease who received maintenance hemodialysis in Shaanxi Provincial People’s Hospital between March 2015 and October 2016 were selected as dialysis group, 102 volunteers who received physical examination in Shaanxi Provincial People’s Hospital during the same period were selected as control group, the EPO resistance index was assessed, the median was calculated, and serum oxidative stress and inflammatory response indexes were detected. Results: Serum T-AOC, SOD and CAT levels in dialysis group were significantly lower than those in control group while MDA, AOPP, IFN-γ, HMGB-1, ICAM-1, IL-4 and IL-10 levels were significantly higher than those in control group; serum T-AOC, SOD and CAT levels in patients with high ERI were significantly lower than those in patients with low ERI while MDA, AOPP, IFN-γ, HMGB-1, ICAM-1, IL-4 and IL-10 levels were significantly higher than those in patients with low ERI. Conclusion: The degree of EPO resistance in patients with maintenance hemodialysis is closely related to the activation of oxidative stress response and inflammatory response.

Quantitative radiation dose-response relationships for normal tissues in man. II. Response of the salivary glands during radiotherapy

International Nuclear Information System (INIS)

Mossman, K.L.

1983-01-01

A quantitative dose-response curve for salivary gland function in patients during radiotherapy is presented. Salivary-function data used in this study were obtained from four previously published reports. All patients were treated with 60 Co teletherapy to the head and neck using conventional treatment techniques. Salivary dysfunction was determined at specific dose levels by comparing salivary flow rates before therapy with flow rates at specific dose intervals during radiotherapy up to a total dose of 6000 cGy. Fifty percent salivary dysfunction occurred after 1000 cGy and eighty percent dysfunction was observed by the end of the therapy course (6000 cGy). The salivary-function curve was also compared to the previously published dose-response curve for taste function. Comparisons of the two curves indicate that salivary dysfunction precedes taste loss and that the shapes of the dose-response curves are different. A new term, tissue tolerance ratio, defined as the ratio of responses of two tissues given the same radiation dose, was used to make the comparisons between gustatory and salivary gland tissue effects. Measurements of salivary gland function and analysis of dose-response curves may be useful in evaluating chemical modifiers of radiation response

Response to Illicit Trafficking of Radioactive Materials

International Nuclear Information System (INIS)

2010-01-01

Two response paths are discussed in the presentation. Reactive response follows when an alarm of a border monitor goes off or a notification is received about an incident involving or suspected to involve radioactive materials. The response can also be the result of the finding of a discrepancy between a customs declaration form and the corresponding actual shipment. Proactive response is undertaken upon receipt of intelligence information suggesting the illicit trafficking of radioactive materials, notification about the discovery of non-compliance with transport regulations or if discrepancies are found in an inventory of radioactive materials.

Attenuation of spurious responses in electromechanical filters

Energy Technology Data Exchange (ETDEWEB)

Olsson, Roy H.; Hietala, Vincent M.

2018-04-10

A spur cancelling, electromechanical filter includes a first resonator having a first resonant frequency and one or more first spurious responses, and it also includes, electrically connected to the first resonator, a second resonator having a second resonant frequency and one or more second spurious responses. The first and second resonant frequencies are approximately identical, but the first resonator is physically non-identical to the second resonator. The difference between the resonators makes the respective spurious responses different. This allows for filters constructed from a cascade of these resonators to exhibit reduced spurious responses.

Response competition and response inhibition during different choice-discrimination tasks: evidence from ERP measured inside MRI scanner.

Science.gov (United States)

Gonzalez-Rosa, Javier J; Inuggi, Alberto; Blasi, Valeria; Cursi, Marco; Annovazzi, Pietro; Comi, Giancarlo; Falini, Andrea; Leocani, Letizia

2013-07-01

We investigated the neural correlates underlying response inhibition and conflict detection processes using ERPs and source localization analyses simultaneously acquired during fMRI scanning. ERPs were elicited by a simple reaction time task (SRT), a Go/NoGo task, and a Stroop-like task (CST). The cognitive conflict was thus manipulated in order to probe the degree to which information processing is shared across cognitive systems. We proposed to dissociate inhibition and interference conflict effects on brain activity by using identical Stroop-like congruent/incongruent stimuli in all three task contexts and while varying the response required. NoGo-incongruent trials showed a larger N2 and enhanced activations of rostral anterior cingulate cortex (ACC) and pre-supplementary motor area, whereas Go-congruent trials showed a larger P3 and increased parietal activations. Congruent and incongruent conditions of the CST task also elicited similar N2, P3 and late negativity (LN) ERPs, though CST-incongruent trials revealed a larger LN and enhanced prefrontal and ACC activations. Considering the stimulus probability and experimental manipulation of our study, current findings suggest that NoGo N2 and frontal NoGo P3 appear to be more associated to response inhibition rather than a specific conflict monitoring, whereas occipito-parietal P3 of Go and CST conditions may be more linked to a planned response competition between the prepared and required response. LN, however, appears to be related to higher level conflict monitoring associated with response choice-discrimination but not when the presence of cognitive conflict is associated with response inhibition. Copyright © 2013. Published by Elsevier B.V.

Dynamics of response-conflict monitoring and individual differences in response control and behavioral control: an electrophysiological investigation using a stop-signal task.

Science.gov (United States)

Stahl, Jutta; Gibbons, Henning

2007-03-01

The aim of the present study was to investigate the functional significance of error (related) negativity Ne/ERN and individual differences in human action monitoring. A response-conflict model of Ne/ERN should be tested applying a stop-signal paradigm. After a few modifications of Ne/ERN response-conflict theory (Yeung N, Botvinick MM, Cohen JD. The neural basis of error detection: conflict monitoring and the error-related negativity. Psychological Review 2004:111(4);931-959), strength and time course of response conflict could be modeled as a function of stop-signal delay. In Experiment 1, 35 participants performed a visual two-choice response-time task but tried to withhold the response if an auditory stop signal was presented. Probability of stopping errors was held at 50% using variable delays between visual and auditory stimuli. Experiment 2 (n=10) employed both auditory go and stop signals and confirmed that Ne/ERN effects are due to conflict induced by the auditory stop signal, and not the mere presence or absence of an additional stimulus. As predicted, amplitudes of both the stimulus-locked and response-locked Ne/ERN were largest for non-stopped responses, followed by successfully stopped and go responses. However, independently of response type Ne/ERN also increased with increasing stop-signal delay. Since longer delay invokes stronger response conflict, results specifically support the notion of Ne/ERN reflecting response-conflict monitoring. Furthermore, individual differences related to measures of response control and behavioral control were observed. Both low response control estimated from stop-task performance and high psychometric impulsivity were accompanied by smaller Ne/ERN amplitude on stop trials, suggesting reduced response-conflict monitoring. The present study supported the response-conflict view of Ne/ERN. Furthermore, the observed relationship between impulsivity and Ne/ERN amplitude suggested that individuals with low behavioral

Mechanisms of subliminal response priming.

Science.gov (United States)

Kiesel, Andrea; Kunde, Wilfried; Hoffmann, Joachim

2008-07-15

Subliminal response priming has been considered to operate on several stages, e.g. perceptual, central or motor stages might be affected. While primes' impact on target perception has been clearly demonstrated, semantic response priming recently has been thrown into doubt (e.g. Klinger, Burton, & Pitts, 2000). Finally, LRP studies have revealed that subliminal primes evoke motor processes. Yet, the premises for such prime-evoked motor activation are not settled. A transfer of priming to stimuli that have never been presented as targets appears particularly interesting because it suggests a level of processing that goes beyond a reactivation of previously acquired S-R links. Yet, such transfer has not always withstood empirical testing. To account for these contradictory results, we proposed a two-process model (Kunde, Kiesel, & Hoffmann, 2003): First, participants build up expectations regarding imperative stimuli for the required responses according to experience and/or instructions. Second, stimuli that match these "action triggers" directly activate the corresponding motor responses irrespective of their conscious identification. In line with these assumptions, recent studies revealed that non-target primes induce priming when they fit the current task intentions and when they are expected in the experimental setting.

Baseline response rates affect resistance to change.

Science.gov (United States)

Kuroda, Toshikazu; Cook, James E; Lattal, Kennon A

2018-01-01

The effect of response rates on resistance to change, measured as resistance to extinction, was examined in two experiments. In Experiment 1, responding in transition from a variable-ratio schedule and its yoked-interval counterpart to extinction was compared with pigeons. Following training on a multiple variable-ratio yoked-interval schedule of reinforcement, in which response rates were higher in the former component, reinforcement was removed from both components during a single extended extinction session. Resistance to extinction in the yoked-interval component was always either greater or equal to that in the variable-ratio component. In Experiment 2, resistance to extinction was compared for two groups of rats that exhibited either high or low response rates when maintained on identical variable-interval schedules. Resistance to extinction was greater for the lower-response-rate group. These results suggest that baseline response rate can contribute to resistance to change. Such effects, however, can only be revealed when baseline response rate and reinforcement rate are disentangled (Experiments 1 and 2) from the more usual circumstance where the two covary. Furthermore, they are more cleanly revealed when the programmed contingencies controlling high and low response rates are identical, as in Experiment 2. © 2017 Society for the Experimental Analysis of Behavior.

40 CFR 1503.4 - Response to comments.

Science.gov (United States)

2010-07-01

... statement. (c) If changes in response to comments are minor and are confined to the responses described in paragraphs (a)(4) and (5) of this section, agencies may write them on errata sheets and attach them to the... thereof where the response has been exceptionally voluminous), should be attached to the final statement...

20 CFR 665.300 - What are rapid response activities and who is responsible for providing them?

Science.gov (United States)

2010-04-01

... responsible for providing them? 665.300 Section 665.300 Employees' Benefits EMPLOYMENT AND TRAINING... natural or other disaster resulting in a mass job dislocation. (b) The State is responsible for providing.... The State must establish methods by which to provide additional assistance to local areas that...

32 CFR 32.41 - Recipient responsibilities.

Science.gov (United States)

2010-07-01

... Federal, State or local authority as may have proper jurisdiction. ..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 32.41... contractual responsibilities arising under its contract(s). The recipient is the responsible authority...

Cell response to surgery.

LENUS (Irish Health Repository)

Ni Choileain, Niamh

2012-02-03

OBJECTIVES: To describe the profound alterations in host immunity that are produced by major surgery as demonstrated by experimental and clinical studies, and to evaluate the benefits of therapeutic strategies aimed at attenuating perioperative immune dysfunction. DATA SOURCES: A review of the English-language literature was conducted, incorporating searches of the MEDLINE, EMBASE, and Cochrane collaboration databases to identify laboratory and clinical studies investigating the cellular response to surgery. STUDY SELECTION: Original articles and case reports describing immune dysfunction secondary to surgical trauma were included. DATA EXTRACTION: The results were compiled to show outcomes of different studies and were compared. DATA SYNTHESIS: Current evidence indicates that the early systemic inflammatory response syndrome observed after major surgery that is characterized by proinflammatory cytokine release, microcirculatory disturbance, and cell-mediated immune dysfunction is followed by a compensatory anti-inflammatory response syndrome, which predisposes the patient to opportunistic infection, multiple organ dysfunction syndrome, and death. Because there are currently no effective treatment options for multiple organ dysfunction syndrome, measures to prevent its onset should be initiated at an early stage. Accumulating experimental evidence suggests that targeted therapeutic strategies involving immunomodulatory agents such as interferon gamma, granulocyte colony-stimulating factor, the prostaglandin E(2) antagonist, indomethacin, and pentoxifylline may be used for the treatment of systemic inflammatory response syndrome to prevent the onset of multiple organ dysfunction syndrome. CONCLUSIONS: Surgical trauma produces profound immunological dysfunction. Therapeutic strategies directed at restoring immune homeostasis should aim to redress the physiological proinflammatory-anti-inflammatory cell imbalance associated with major surgery.

CV equipment responsibilities

CERN Document Server

Pirollet, B

2008-01-01

This document describes the limits of the responsibilities of the TS/CV for fire fighting equipment at the LHC. The various interfaces, providers and users of the water supply systems and clean water raising systems are described.

Assessing item fit for unidimensional item response theory models using residuals from estimated item response functions.

Science.gov (United States)

Haberman, Shelby J; Sinharay, Sandip; Chon, Kyong Hee

2013-07-01

Residual analysis (e.g. Hambleton & Swaminathan, Item response theory: principles and applications, Kluwer Academic, Boston, 1985; Hambleton, Swaminathan, & Rogers, Fundamentals of item response theory, Sage, Newbury Park, 1991) is a popular method to assess fit of item response theory (IRT) models. We suggest a form of residual analysis that may be applied to assess item fit for unidimensional IRT models. The residual analysis consists of a comparison of the maximum-likelihood estimate of the item characteristic curve with an alternative ratio estimate of the item characteristic curve. The large sample distribution of the residual is proved to be standardized normal when the IRT model fits the data. We compare the performance of our suggested residual to the standardized residual of Hambleton et al. (Fundamentals of item response theory, Sage, Newbury Park, 1991) in a detailed simulation study. We then calculate our suggested residuals using data from an operational test. The residuals appear to be useful in assessing the item fit for unidimensional IRT models.

Respiratory epithelial cell responses to cigarette smoke: the unfolded protein response.

Science.gov (United States)

Kelsen, Steven G

2012-12-01

Cigarette smoking exposes the respiratory epithelium to highly toxic, reactive oxygen nitrogen species which damage lung proteins in the endoplasmic reticulum (ER), the cell organelle in which all secreted and membrane proteins are processed. Accumulation of damaged or misfolded proteins in the ER, a condition termed ER stress, activates a complex cellular process termed the unfolded protein responses (UPR). The UPR acts to restore cellular protein homeostasis by regulating all aspects of protein metabolism including: protein translation and syntheses; protein folding; and protein degradation. However, activation of the UPR may also induce signaling pathways which induce inflammation and cell apoptosis. This review discusses the role of UPR in the respiratory epithelial cell response to cigarette smoke and the pathogenesis of lung diseases like COPD. Copyright © 2012 Elsevier Ltd. All rights reserved.

Programmed cellular response to ionizing radiation damage

International Nuclear Information System (INIS)

Crompton, N.E.A.

1998-01-01

Three forms of radiation response were investigated to evaluate the hypothesis that cellular radiation response is the result of active molecular signaling and not simply a passive physicochemical process. The decision whether or not a cell should respond to radiation-induced damage either by induction of rescue systems, e.g. mobilization of repair proteins, or induction of suicide mechanisms, e.g. programmed cell death, appears to be the expression of intricate cellular biochemistry. A cell must recognize damage in its genetic material and then activate the appropriate responses. Cell type is important; the response of a fibroblast to radiation damage is both quantitatively and qualitatively different form that of a lymphocyte. The programmed component of radiation response is significant in radiation oncology and predicted to create unique opportunities for enhanced treatment success. (orig.)

Exogenously triggered response inhibition in developmental stuttering.

Science.gov (United States)

Eggers, Kurt; De Nil, Luc F; Van den Bergh, Bea R H

2018-06-01

The purpose of the present study was to examine relations between children's exogenously triggered response inhibition and stuttering. Participants were 18 children who stutter (CWS; mean age = 9;01 years) and 18 children who not stutter (CWNS; mean age = 9;01 years). Participants were matched on age (±3 months) and gender. Response inhibition was assessed by a stop signal task (Verbruggen, Logan, & Stevens, 2008). Results suggest that CWS, compared to CWNS, perform comparable to CWNS in a task where response control is externally triggered. Our findings seem to indicate that previous questionnaire-based findings (Eggers, De Nil, & Van den Bergh, 2010) of a decreased efficiency of response inhibition cannot be generalized to all types of response inhibition. Copyright © 2018 Elsevier Inc. All rights reserved.

Stock Performance of Socially Responsible Companies

Directory of Open Access Journals (Sweden)

Huang Tzu-Man

2016-12-01

Full Text Available Every year Corporate Responsibility Magazine selects and ranks 100 companies on the basis of their corporate social responsibility. This study investigates the stock performance of socially responsible companies in the U.S. The monthly stock returns for these companies are analyzed and compared with the market performance, with the S&P 500 index designated as a proxy for the market. The empirical evidence suggests that these 100 companies outperform the market in their monthly stock returns. We also narrow down the number of companies selected to the top 75, 50, 25, and 10 firms. As we narrow down the companies selected, the difference between their returns and the market returns also narrows. In other words, a portfolio that includes all top 100 companies provides the best stock performance. We extend the analysis to long-term annual stock performance. We find that these socially responsible companies′ annual returns are higher than the market returns for up to seven years after they are listed. We also conduct the same analysis on the top 75, 50, 25, and 10 firms, respectively. Similarly, the larger the number of these top 100 companies, the greater the tendency to generate higher annual returns. We suspect that because the difference between the socially responsible companies′ average returns and the market returns is not dramatic, with a bigger population and thus a larger sample size, the difference becomes more significant. However, in practice, transaction costs must be considered. This study is limited in that it does not consider transaction costs. Nevertheless, we hope to shed some light on the issue of socially responsible companies′ stock performance to encourage companies to start thinking about the importance of corporate social responsibility.

Moral responsibility for (un)healthy behaviour.

Science.gov (United States)

Brown, Rebecca C H

2013-11-01

Combatting chronic, lifestyle-related disease has become a healthcare priority in the developed world. The role personal responsibility should play in healthcare provision has growing pertinence given the growing significance of individual lifestyle choices for health. Media reporting focussing on the 'bad behaviour' of individuals suffering lifestyle-related disease, and policies aimed at encouraging 'responsibilisation' in healthcare highlight the importance of understanding the scope of responsibility ascriptions in this context. Research into the social determinants of health and psychological mechanisms of health behaviour could undermine some commonly held and tacit assumptions about the moral responsibility of agents for the sorts of lifestyles they adopt. I use Philip Petit's conception of freedom as 'fitness to be held responsible' to consider the significance of some of this evidence for assessing the moral responsibility of agents. I propose that, in some cases, factors outside the agent's control may influence behaviour in such a way as to undermine her freedom along the three dimensions described by Pettit: freedom of action; a sense of identification with one's actions; and whether one's social position renders one vulnerable to pressure from more powerful others.

HiSCR (Hidradenitis Suppurativa Clinical Response)

DEFF Research Database (Denmark)

Kimball, B. A.; Sobell, J. M.; Zouboulis, C C

2016-01-01

Background: Determining treatment response for patients with hidradenitis suppurativa (HS) can be challenging due to limitations of current disease activity evaluations. Objective: Evaluate the novel, validated endpoint, Hidradenitis Suppurativa Clinical Response (HiSCR) and its utility as an out......Background: Determining treatment response for patients with hidradenitis suppurativa (HS) can be challenging due to limitations of current disease activity evaluations. Objective: Evaluate the novel, validated endpoint, Hidradenitis Suppurativa Clinical Response (HiSCR) and its utility...... as an outcome measure. Methods: Patients with baseline total abscess and inflammatory nodule count (AN count) of at least three and draining fistula count of 20 or fewer comprised the post hoc subpopulation analysed. HiSCR (at least a 50% reduction in total AN count, with no increase in abscess count...... week, or placebo (1 : 1 : 1). Results: The subpopulation included 132 (85.7%) patients; 70.5% women and 73.5% white. At week 16, HiSCR was achieved by 54.5% receiving weekly adalimumab, 33.3% every other week, and 25.6% placebo and HS-PGA Response was achieved by 20.5% receiving weekly adalimumab, 6...

A Ranking Method for Evaluating Constructed Responses

Science.gov (United States)

Attali, Yigal

2014-01-01

This article presents a comparative judgment approach for holistically scored constructed response tasks. In this approach, the grader rank orders (rather than rate) the quality of a small set of responses. A prior automated evaluation of responses guides both set formation and scaling of rankings. Sets are formed to have similar prior scores and…

Linking physiological and cellular responses to thermal stress: β-adrenergic blockade reduces the heat shock response in fish.

Science.gov (United States)

Templeman, Nicole M; LeBlanc, Sacha; Perry, Steve F; Currie, Suzanne

2014-08-01

When faced with stress, animals use physiological and cellular strategies to preserve homeostasis. We were interested in how these high-level stress responses are integrated at the level of the whole animal. Here, we investigated the capacity of the physiological stress response, and specifically the β-adrenergic response, to affect the induction of the cellular heat shock proteins, HSPs, following a thermal stress in vivo. We predicted that blocking β-adrenergic stimulation during an acute heat stress in the whole animal would result in reduced levels of HSPs in red blood cells (RBCs) of rainbow trout compared to animals where adrenergic signaling remained intact. We first determined that a 1 h heat shock at 25 °C in trout acclimated to 13 °C resulted in RBC adrenergic stimulation as determined by a significant increase in cell swelling, a hallmark of the β-adrenergic response. A whole animal injection with the β2-adrenergic antagonist, ICI-118,551, successfully reduced this heat-induced RBC swelling. The acute heat shock caused a significant induction of HSP70 in RBCs of 13 °C-acclimated trout as well as a significant increase in plasma catecholamines. When heat-shocked fish were treated with ICI-118,551, we observed a significant attenuation of the HSP70 response. We conclude that circulating catecholamines influence the cellular heat shock response in rainbow trout RBCs, demonstrating physiological/hormonal control of the cellular stress response.

Elastic-plastic response characteristics during frequency nonstationary waves

International Nuclear Information System (INIS)

Miyama, T.; Kanda, J.; Iwasaki, R.; Sunohara, H.

1987-01-01

The purpose of this paper is to study fundamental effects of the frequency nonstationarity on the inelastic responses. First, the inelastic response characteristics are examined by applying stationary waves. Then simple representation of nonstationary characteristics is considered to general nonstationary input. The effects for frequency nonstationary response are summarized for inelastic systems. The inelastic response characteristics under white noise and simple frequency nonstationary wave were investigated, and conclusions can be summarized as follows. 1) The maximum response values for both BL model and OO model corresponds fairly well with those estimated from the energy constant law, even when R is small. For the OO model, the maximum displacement response forms a unique curve except for very small R. 2) The plastic deformation for the BL model is affected by wide frequency components, as R decreases. The plastic deformation for the OO model can be determined from the last stiffness. 3). The inelastic response of the BL model is considerably affected by the frequency nonstationarity of the input motion, while the response is less affected by the nonstationarity for OO model. (orig./HP)

Market design for rapid demand response