WorldWideScience

Sample records for hub heights typically

  1. A new method for improved hub height mean wind speed estimates using short-term hub height data

    Energy Technology Data Exchange (ETDEWEB)

    Lackner, Matthew A.; Rogers, Anthony L.; Manwell, James F.; McGowan, Jon G. [Wind Energy Center, Department of Mechanical and Industrial Engineering, University of Massachusetts Amherst, 160 Governors Dr., Amherst, MA 01003 (United States)

    2010-10-15

    The estimation of the wind resource at the hub height of a wind turbine is one of the primary goals of site assessment. Because the measurement heights of meteorological towers (met towers) are typically significantly lower than turbine hub heights, a shear model is generally needed to extrapolate the measured wind resource at the lower measurement height to the hub height of the turbine. This paper presents methods for improving the estimate of the hub height wind resource from met tower data through the use of ground-based remote sensing devices. The methods leverage the two major advantages of these devices: their portability and their ability to measure at the wind turbine hub height. Specifically, the methods rely on augmenting the one year of met tower measurements with short-term measurements from a ground-based remote sensing device. The results indicate that the methods presented are capable of producing substantial improvements in the accuracy and uncertainty of shear extrapolation predictions. The results suggest that the typical site assessment process can be reevaluated, and alternative strategies that utilize ground-based remote sensing devices can be incorporated to significantly improve the process. (author)

  2. On the Predictability of Hub Height Winds

    DEFF Research Database (Denmark)

    Draxl, Caroline

    Wind energy is a major source of power in over 70 countries across the world, and the worldwide share of wind energy in electricity consumption is growing. The introduction of signicant amounts of wind energy into power systems makes accurate wind forecasting a crucial element of modern electrical...... grids. These systems require forecasts with temporal scales of tens of minutes to a few days in advance at wind farm locations. Traditionally these forecasts predict the wind at turbine hub heights; this information is then converted by transmission system operators and energy companies into predictions...... of power output at wind farms. Since the power available in the wind is proportional to the wind speed cubed, even small wind forecast errors result in large power prediction errors. Accurate wind forecasts are worth billions of dollars annually; forecast improvements will result in reduced costs...

  3. A New Approach for Offshore Wind Farm Energy Yields Calculation with Mixed Hub Height Wind Turbines

    DEFF Research Database (Denmark)

    Hou, Peng; Hu, Weihao; Soltani, Mohsen

    2016-01-01

    In this paper, a mathematical model for calculating the energy yields of offshore wind farm with mixed types of wind turbines is proposed. The Jensen model is selected as the base and developed to a three dimension wake model to estimate the energy yields. Since the wind turbines are with different...... hub heights, the wind shear effect is also taken into consideration. The results show that the proposed wake model is effective in calculating the wind speed deficit. The calculation framework is applicable for energy yields calculation in offshore wind farms....

  4. Hexcrete Tower for Harvesting Wind Energy at Taller Hub Heights - Budget Period 2

    Energy Technology Data Exchange (ETDEWEB)

    Sritharan, Sri [Iowa State Univ., Ames, IA (United States)

    2017-05-01

    Interest in designing taller towers for wind energy production in the United States (U.S.) has been steadily growing. In May 2015, it was revealed that taller towers will make wind energy production a reality in all 50 states, including some states that have nearly zero renewables in their energy portfolio. Facilitating wind energy production feasibility in all 50 states will no doubt contribute to increasing the electricity produced by wind from 4.5% in 2013 to a targeted scenario of 35% by 2050 in the Wind Vision report. This project focuses on the Hexcrete tower concept developed for tall towers using High Strength Concrete (HSC) and/or Ultra-High Performance Concrete (UHPC). Among other benefits, the Hexcrete concept overcomes transportation and logistical challenges, thus facilitating construction of towers with hub heights of 100-m (328-ft) and higher. The goal of this project is to facilitate widespread deployment of Hexcrete towers for harvesting wind energy at 120 to 140-m (394 to 459-ft) hub heights and reduce the Levelized Cost of Energy (LCOE) of wind energy production in the U.S. The technical scope of the project includes detailed design and optimization of at least three wind turbine towers using the Hexcrete concept together with experimental validation and LCOE analyses and development of a commercialization plan.

  5. Dependence of gait parameters on height in typically developing children.

    Science.gov (United States)

    Agostini, Valentina; Nascimbeni, Alberto; Di Nardo, Francesco; Fioretti, Sandro; Burattini, Laura; Knaflitz, Marco

    2015-01-01

    In clinical gait analysis is fundamental to have access to normative data, to be used as a reference in the interpretation of pathological walking. In a paediatric population this may be complicated by the dependence of gait parameters on child growth. The aim of this work is to provide the correlations of spatial-temporal gait parameters with children's height. We obtained the regression lines of cadence, double support, and gait phases, with respect to height, from a sample of 85 normally typically developing children aged 6 to 11. Our analysis of gait phases was not limited to the traditional analysis of stance and swing, but rather focused on the sub-phases of stance - heel contact, flat foot contact, push off - which proved to be an innovative approach to gait analysis. Heel contact decreased, flat foot contact increased and push off remained essentially unchanged with respect to children's height. These results may be useful in the interpretation of gait data in developing children, and the regression lines obtained may be used to normalize their gait parameters.

  6. Final Report for Project: Impacts of stratification and non-equilibrium winds and waves on hub-height winds

    Energy Technology Data Exchange (ETDEWEB)

    Patton, Edward G. [Univ. Corporation for Atmospheric Research, Boulder, CO (United States)

    2015-07-14

    This project used a combination of turbulence-resolving large-eddy simulations, single-column modeling (where turbulence is parameterized), and currently available observations to improve, assess, and develop a parameterization of the impact of non-equilibrium wave states and stratification on the buoy-observed winds to establish reliable wind data at the turbine hub-height level. Analysis of turbulence-resolving simulations and observations illuminates the non-linear coupling between the atmosphere and the undulating sea surface. This analysis guides modification of existing boundary layer parameterizations to include wave influences for upward extrapolation of surface-based observations through the turbine layer. Our surface roughness modifications account for the interaction between stratification and the effects of swell’s amplitude and wavelength as well as swell’s relative motion with respect to the mean wind direction. The single-column version of the open source Weather and Research Forecasting (WRF) model (Skamarock et al., 2008) serves as our platform to test our proposed planetary boundary layer parameterization modifications that account for wave effects on marine atmospheric boundary layer flows. WRF has been widely adopted for wind resource analysis and forecasting. The single column version is particularly suitable to development, analysis, and testing of new boundary layer parameterizations. We utilize WRF’s single-column version to verify and validate our proposed modifications to the Mellor-Yamada-Nakanishi-Niino (MYNN) boundary layer parameterization (Nakanishi and Niino, 2004). We explore the implications of our modifications for two-way coupling between WRF and wave models (e.g.,Wavewatch III). The newly implemented parameterization accounting for marine atmospheric boundary layer-wave coupling is then tested in three-dimensional WRF simulations at grid sizes near 1 km. These simulations identify the behavior of simulated winds at the

  7. Hub Height Ocean Winds over the North Sea Observed by the NORSEWInD Lidar Array: Measuring Techniques, Quality Control and Data Management

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Stein, Detlef; Courtney, Michael

    2013-01-01

    In the North Sea, an array of wind profiling wind lidars were deployed mainly on offshore platforms. The purpose was to observe free stream winds at hub height. Eight lidars were validated prior to offshore deployment with observations from cup anemometers at 60, 80, 100 and 116 m on an onshore met....... The flow distortion around platforms was examined using wind tunnel experiments and computational fluid dynamics and it was found that at 100 m height wind observations by the lidars were not significantly influenced by flow distortion. Observations of the vertical wind profile shear exponent at hub height...

  8. Final Report for Project: Impacts of stratification and non-equilibrium winds and waves on hub-height winds

    Energy Technology Data Exchange (ETDEWEB)

    Patton, Edward G. [Univ. Corporation for Atmospheric Research, Boulder, CO (United States)

    2015-07-14

    This project used a combination of turbulence-resolving large-eddy simulations, single-column modeling (where turbulence is parameterized), and currently available observations to improve, assess, and develop a parameterization of the impact of non-equilibrium wave states and stratification on the buoy-observed winds to establish reliable wind data at the turbine hub-height level. Analysis of turbulence-resolving simulations and observations illuminates the non-linear coupling between the atmosphere and the undulating sea surface. This analysis guides modification of existing boundary layer parameterizations to include wave influences for upward extrapolation of surface-based observations through the turbine layer. Our surface roughness modifications account for the interaction between stratification and the effects of swell’s amplitude and wavelength as well as swell’s relative motion with respect to the mean wind direction. The single-column version of the open source Weather and Research Forecasting (WRF) model (Skamarock et al., 2008) serves as our platform to test our proposed planetary boundary layer parameterization modifications that account for wave effects on marine atmospheric boundary layer flows. WRF has been widely adopted for wind resource analysis and forecasting. The single column version is particularly suitable to development, analysis, and testing of new boundary layer parameterizations. We utilize WRF’s single-column version to verify and validate our proposed modifications to the Mellor-Yamada-Nakanishi-Niino (MYNN) boundary layer parameterization (Nakanishi and Niino, 2004). We explore the implications of our modifications for two-way coupling between WRF and wave models (e.g.,Wavewatch III). The newly implemented parameterization accounting for marine atmospheric boundary layer-wave coupling is then tested in three-dimensional WRF simulations at grid sizes near 1 km. These simulations identify the behavior of simulated winds at the

  9. On the Improvement of Numerical Weather Prediction by Assimilation of Hub Height Wind Information in Convection-Resulted Models

    Science.gov (United States)

    Declair, Stefan; Stephan, Klaus; Potthast, Roland

    2015-04-01

    Determining the amount of weather dependent renewable energy is a demanding task for transmission system operators (TSOs). In the project EWeLiNE funded by the German government, the German Weather Service and the Fraunhofer Institute on Wind Energy and Energy System Technology strongly support the TSOs by developing innovative weather- and power forecasting models and tools for grid integration of weather dependent renewable energy. The key in the energy prediction process chain is the numerical weather prediction (NWP) system. With focus on wind energy, we face the model errors in the planetary boundary layer, which is characterized by strong spatial and temporal fluctuations in wind speed, to improve the basis of the weather dependent renewable energy prediction. Model data can be corrected by postprocessing techniques such as model output statistics and calibration using historical observational data. On the other hand, latest observations can be used in a preprocessing technique called data assimilation (DA). In DA, the model output from a previous time step is combined such with observational data, that the new model data for model integration initialization (analysis) fits best to the latest model data and the observational data as well. Therefore, model errors can be already reduced before the model integration. In this contribution, the results of an impact study are presented. A so-called OSSE (Observation Simulation System Experiment) is performed using the convective-resoluted COSMO-DE model of the German Weather Service and a 4D-DA technique, a Newtonian relaxation method also called nudging. Starting from a nature run (treated as the truth), conventional observations and artificial wind observations at hub height are generated. In a control run, the basic model setup of the nature run is slightly perturbed to drag the model away from the beforehand generated truth and a free forecast is computed based on the analysis using only conventional

  10. Innovation hubs

    DEFF Research Database (Denmark)

    O´Hara, J.; Hansen, Poul H. Kyvsgård; Turner, N.

    2008-01-01

    "Whilst ‘incremental innovation' is an imperative for the short-to-medium term success of a company, there is also a need for companies to engage in innovation activity that goes beyond the incremental in order to guarantee long-term success. However, such ‘radical innovation' (RI) poses new...... challenges and requires new competencies, some of which may conflict with existing best-practices for incremental innovations. ‘Innovation hubs' are a type of organisational structure dedicated to RI projects that have been used by companies to manage these conflicts by maintaining a certain degree...... of separation from the culture and routines of the mainstream organisation. Unfortunately, it would appear that many attempts to set-up innovation hubs have ended in failure within a few years; not before considerable time, effort and resource has been expended. This paper reports on a study of six innovation...

  11. Innovation hubs

    DEFF Research Database (Denmark)

    O´Hara, J.; Hansen, Poul H. Kyvsgård; Turner, N.

    2008-01-01

    "Whilst ‘incremental innovation' is an imperative for the short-to-medium term success of a company, there is also a need for companies to engage in innovation activity that goes beyond the incremental in order to guarantee long-term success. However, such ‘radical innovation' (RI) poses new...... challenges and requires new competencies, some of which may conflict with existing best-practices for incremental innovations. ‘Innovation hubs' are a type of organisational structure dedicated to RI projects that have been used by companies to manage these conflicts by maintaining a certain degree...... of separation from the culture and routines of the mainstream organisation. Unfortunately, it would appear that many attempts to set-up innovation hubs have ended in failure within a few years; not before considerable time, effort and resource has been expended. This paper reports on a study of six innovation...

  12. Over-heated Investment in Aluminum Hub Industry

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>Aluminum hub is one of typical products with the comparative advantages.China’s aluminum hub industry is very competitive.In recent years,the value of export for the aluminum hub soared,increasing from USD130 millions in 1999 up to nearly USD1 billion in 2004.The main exporter are Wanfeng Auto Holding Group,Shanghai Fervent Alloy Wheel MFG Co.,Ltd.,Nanhai Zhongnan Aluminum Co., Ltd.,Taian Huatai Aluminum Hub Co.,Ltd.

  13. Natural Gas Market Hubs

    Data.gov (United States)

    Department of Homeland Security — A hub is a physical transfer point for natural gas where several pipelines are connected. A market center is a hub where the operator offers services that facilitate...

  14. Bringing satellite winds to hub-height

    DEFF Research Database (Denmark)

    Badger, Merete; Pena Diaz, Alfredo; Bredesen, Rolv Erlend

    2012-01-01

    Satellite observations of the ocean surface can provide detailed information about the spatial wind variability over large areas. This is very valuable for the mapping of wind resources offshore where other measurements are costly and sparse. Satellite sensors operating at microwave frequencies...... measure the amount of radar backscatter from the sea surface, which is a function of the instant wind speed, wind direction, and satellite viewing geometry. A major limitation related to wind retrievals from satellite observations is that existing empirical model functions relate the radar backscatter...

  15. Bringing satellite winds to hub-height

    DEFF Research Database (Denmark)

    Badger, Merete; Pena Diaz, Alfredo; Bredesen, Rolv Erlend

    2012-01-01

    Satellite observations of the ocean surface can provide detailed information about the spatial wind variability over large areas. This is very valuable for the mapping of wind resources offshore where other measurements are costly and sparse. Satellite sensors operating at microwave frequencies m...

  16. Quadratic Assignment of Hubs in p-Hub Median Problem

    DEFF Research Database (Denmark)

    Gelareh, Shahin

    We introduce Generalized p-Hub Median Problem (GpHMP) that seeks to locate p hub nodes and install p distinct hub facilities/operators on the hubs while discount factor resulted by consolidation of flow on the hub links depends on the facilities/operators that are installed/operating on both hub...... nodes end-point. In contrast, in traditional hub location problems it is commonly assumed that all the hub facilities share a similar characteristic and economy of scale resulted by consolidation of flow over hub edges is not directly relevant to the hub facilities being installed at both end...

  17. Virtual Campus Hub technology

    DEFF Research Database (Denmark)

    Vercoulen, Frank; Badger, Merete; Monaco, Lucio;

    This deliverable briefly describes which technological components have been delivered for the Virtual Campus Hub and how they can be used. A detailed discussion of the technical details of the components, how they were realized and how they fit the VCH concept can be found in deliverables D5.......4. Virtual Campus Hub Technology Evaluation Report and D6.7 The Virtual Campus Hub Concept....

  18. Aircraft Propeller Hub Repair

    Energy Technology Data Exchange (ETDEWEB)

    Muth, Thomas R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Peter, William H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-02-13

    The team performed a literature review, conducted residual stress measurements, performed failure analysis, and demonstrated a solid state additive manufacturing repair technique on samples removed from a scrapped propeller hub. The team evaluated multiple options for hub repair that included existing metal buildup technologies that the Federal Aviation Administration (FAA) has already embraced, such as cold spray, high velocity oxy-fuel deposition (HVOF), and plasma spray. In addition the team helped Piedmont Propulsion Systems, LLC (PPS) evaluate three potential solutions that could be deployed at different stages in the life cycle of aluminum alloy hubs, in addition to the conventional spray coating method for repair. For new hubs, a machining practice to prevent fretting with the steel drive shaft was recommended. For hubs that were refurbished with some material remaining above the minimal material condition (MMC), a silver interface applied by an electromagnetic pulse additive manufacturing method was recommended. For hubs that were at or below the MMC, a solid state additive manufacturing technique using ultrasonic welding (UW) of thin layers of 7075 aluminum to the hub interface was recommended. A cladding demonstration using the UW technique achieved mechanical bonding of the layers showing promise as a viable repair method.

  19. Twin Hub Network (poster)

    NARCIS (Netherlands)

    Kreutzberger, E.D.; Konings, J.W.

    2014-01-01

    Twin hub network, a European Interreg IVB project, aims at making intermodal rail transport within, to and from North West Europe more competitive, in particular between seaports and inland terminals. Improving rail competitiveness enables to shift freight flows from road to rail, providing a more s

  20. Transport hub flow modelling

    OpenAIRE

    Despagne, Wilfried; Frenod, Emmanuel

    2014-01-01

    Purpose: The purpose of this paper is to investigate the road freight haulage activity. Using the physical and data flow information from a freight forwarder, we intend to model the flow of inbound and outbound goods in a freight transport hub. Approach: This paper presents the operation of a road haulage group. To deliver goods within two days to any location in France, a haulage contractor needs to be part of a network. This network handles the processing of both physical goods and data. We...

  1. GitHub Android

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    代码托管仓库GitHub发布了官方,Android客户端,手机和平板用户可以从GoogleP1ay下载。它的出现,将方便更多用户融入GitHub社区。GitHubAndroid本身也是开源软件,其源代码可以从GitHub浏览。此前,GitHub已经推出了Windows和Mac版客户端。

  2. PORTS WRESTLE FOR HUB STATUS

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Due to the fact that there has been nocontainer transport hub port in NorthernChina,northern ports are striving fordevelopment and trying to secure a positionof being the hub port in Northern Chinaahead of others. According to media reports,EasternChina’s Shandong Province will invest 5billion yuan(US$604 million)in buildinga Qingdao international shipping hub thatisbased on existing ports in theShandong Peninsula.

  3. Indico: A Collaboration Hub

    CERN Document Server

    Ferreira, P; Bossy, C; Gonzalez, J B; Pugh, M; Resco, A; Trzaskoma, J; Wachter, C

    2012-01-01

    Since 2009, the development of Indico has focused on usability, performance and new features, especially the ones related to meeting collaboration. Usability studies have resulted in the biggest change Indico has experienced up to now, a new web layout that makes user experience better. Performance improvements were also a key goal since 2010; the main features of Indico have been optimized remarkably. Along with usability and performance, new features have been added to Indico such as webchat integration, video services bookings, webcast and recording requests, designed to really reinforce Indico position as the main hub for all CERN collaboration services, and many others which aim is to complete the conference lifecycle management. Indico development is also moving towards a broader collaboration where other institutes, hosting their own Indico instance, can contribute to the project in order make it a better and more complete tool.

  4. The prediction and validation of spatial variation of storm tide height along the coastline of North Somerset, U.K. during extreme events typical of coastal flooding using Synthetic Aperture Radar.

    Science.gov (United States)

    Lewis, Matt; Schumann, Guy; Horsburgh, Kevin; Bates, Paul

    2010-05-01

    Inundation modellers are faced with the problem of determining coastal flood risk in a future climate in order to aid planners, policy makers and engineers. Current research suggests a major source of uncertainty is the water-level height along the coastline which is used to force 2D inundation models of the region studied. Recent research has indicated that the spatial variation of the water-level during a storm (storm tide) has a predictable spatial relationship based upon historical storm events, however, this new proposed method needs to be validated. Detailed observations of a storm tide along a coastline are very rare, but it is believed that Synthetic Aperture Radar (SAR) can be employed with the "water-line method" to provide this detailed dataset of observed water heights. This project is accessing the degree to which current space-borne SAR imagery can be used to determine detailed water-level heights along a coastline during an extreme water-level event typical of a coastal flood, and then employing this dataset to validate a new spatial storm tide variation prediction method. Future inundation risk models may benefit from this research with an improved and more accurate forcing condition, but also oceanographers and coastal scientists can employ the SAR imagery-derived water level approach developed within this work to aid storm surge and coastal inundation research.

  5. The Virtual Campus Hub Concept

    DEFF Research Database (Denmark)

    Badger, Merete; Prag, Sidsel-Marie Winther; Monaco, Lucio

    of Technology in Sweden, Politecnico di Torino in Italy, and Eindhoven University of Technology in the Netherlands. The project is partially funded by the European Commission under the 7th Framework Programme (project no. RI-283746). This report describes the final concept of Virtual Campus Hub. It gives...... an overview of the project achievements and recommends best practices for the use of the Virtual Campus Hub elements: a series of applications for online teaching and collaboration which are connected to a technical platform, the Virtual Campus Hub portal, using the European research infrastructure Géant/eduGAIN....

  6. A new transport hub

    CERN Multimedia

    Corinne Pralavorio

    2016-01-01

    CERN’s new Mobility Centre, allowing you to switch easily from one mode of transport to another, has just been officially opened.   Inauguration of the CERN Mobility Centre by Martin Steinacher, Director for Finance and Human Resources, and Lluis Miralles, Head of the SMB department. CERN’s new Mobility Centre, on the car park next to the Globe of Science and Innovation was officially opened on Tuesday, 22 March. The centre brings together all of CERN’s transport options in a single location. "Our aim is to create an intermodal hub where CERN users and personnel can switch from one mode of transport to another, and from CERN transport to public transport," explains Lluis Miralles, head of the Site Management and Buildings (SMB) department. The Mobility Centre incorporates the CERN bike and car rental services, the self-service car- and bike-sharing schemes, and SIXT car rental facilities (for long-distance journeys). It is located right ne...

  7. Mapping multiplex hubs in human functional brain networks

    Directory of Open Access Journals (Sweden)

    Alex Arenas

    2016-07-01

    Full Text Available Typical brain networks consist of many peripheral regions and a few highly centralones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studieshave shown that networks, obtained from the analysis of specific frequency components ofbrain activity, present peculiar architectures with unique profiles of region centrality. However,the identification of hubs in networks built from different frequency bands simultaneouslyis still a challenging problem, remaining largely unexplored. Here we identify eachfrequency component with one layer of a multiplex network and face this challenge by exploitingthe recent advances in the analysis of multiplex topologies. First, we show that eachfrequency band carries unique topological information, fundamental to accurately modelbrain functional networks. We then demonstrate that hubs in the multiplex network, in generaldifferent from those ones obtained after discarding or aggregating the measured signalsas usual, provide a more accurate map of brain’s most important functional regions, allowingto distinguish between healthy and schizophrenic populations better than conventionalnetwork approaches.

  8. Estimating the sustainability of hubs

    NARCIS (Netherlands)

    Lieshout, R.; Zuidberg, J.; Veldhuis, J.

    2008-01-01

    Several airports in the world are or will be confronted with capacity problems in the near future. As a result of this congestion, many airports will face a selectivity problem: which traffic segments must be accommodated and which segments are less crucial? At hub airports there is generally one

  9. Beijing: Next International Financial Hub?

    Institute of Scientific and Technical Information of China (English)

    Li Zhen

    2008-01-01

    @@ Beijing's new financial dream On May 5,the Beijing Municipal Government released a notice regarding its plans to spur the financial industry,vowing to put forth a strong effort to become the national financial decision-making center,financial management center and financial information and services center,and formally announcing its ambitious aspiration to become a financial hub with international influence.

  10. Solving Hub Network Problem Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Mursyid Hasan Basri

    2012-01-01

    Full Text Available This paper addresses a network problem that described as follows. There are n ports that interact, and p of those will be designated as hubs. All hubs are fully interconnected. Each spoke will be allocated to only one of available hubs. Direct connection between two spokes is allowed only if they are allocated to the same hub. The latter is a distinct characteristic that differs it from pure hub-and-spoke system. In case of pure hub-and-spoke system, direct connection between two spokes is not allowed. The problem is where to locate hub ports and to which hub a spoke should be allocated so that total transportation cost is minimum. In the first model, there are some additional aspects are taken into consideration in order to achieve a better representation of the problem. The first, weekly service should be accomplished. Secondly, various vessel types should be considered. The last, a concept of inter-hub discount factor is introduced. Regarding the last aspect, it represents cost reduction factor at hub ports due to economies of scale. In practice, it is common that the cost rate for inter-hub movement is less than the cost rate for movement between hub and origin/destination. In this first model, inter-hub discount factor is assumed independent with amount of flows on inter-hub links (denoted as flow-independent discount policy. The results indicated that the patterns of enlargement of container ship size, to some degree, are similar with those in Kurokawa study. However, with regard to hub locations, the results have not represented the real practice. In the proposed model, unsatisfactory result on hub locations is addressed. One aspect that could possibly be improved to find better hub locations is inter-hub discount factor. Then inter-hub discount factor is assumed to depend on amount of inter-hub flows (denoted as flow-dependent discount policy. There are two discount functions examined in this paper. Both functions are characterized by

  11. Solving Hub Network Problem Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Mursyid Hasan Basri

    2012-01-01

    Full Text Available This paper addresses a network problem that described as follows. There are n ports that interact, and p of those will be designated as hubs. All hubs are fully interconnected. Each spoke will be allocated to only one of available hubs. Direct connection between two spokes is allowed only if they are allocated to the same hub. The latter is a distinct characteristic that differs it from pure hub-and-spoke system. In case of pure hub-and-spoke system, direct connection between two spokes is not allowed. The problem is where to locate hub ports and to which hub a spoke should be allocated so that total transportation cost is minimum. In the first model, there are some additional aspects are taken into consideration in order to achieve a better representation of the problem. The first, weekly service should be accomplished. Secondly, various vessel types should be considered. The last, a concept of inter-hub discount factor is introduced. Regarding the last aspect, it represents cost reduction factor at hub ports due to economies of scale. In practice, it is common that the cost rate for inter-hub movement is less than the cost rate for movement between hub and origin/destination. In this first model, inter-hub discount factor is assumed independent with amount of flows on inter-hub links (denoted as flow-independent discount policy. The results indicated that the patterns of enlargement of container ship size, to some degree, are similar with those in Kurokawa study. However, with regard to hub locations, the results have not represented the real practice. In the proposed model, unsatisfactory result on hub locations is addressed. One aspect that could possibly be improved to find better hub locations is inter-hub discount factor. Then inter-hub discount factor is assumed to depend on amount of inter-hub flows (denoted as flow-dependent discount policy. There are two discount functions examined in this paper. Both functions are characterized by

  12. PolarHub: A Global Hub for Polar Data Discovery

    Science.gov (United States)

    Li, W.

    2014-12-01

    This paper reports the outcome of a NSF project in developing a large-scale web crawler PolarHub to discover automatically the distributed polar dataset in the format of OGC web services (OWS) in the cyberspace. PolarHub is a machine robot; its goal is to visit as many webpages as possible to find those containing information about polar OWS, extract this information and store it into the backend data repository. This is a very challenging task given huge data volume of webpages on the Web. Three unique features was introduced in PolarHub to make it distinctive from earlier crawler solutions: (1) a multi-task, multi-user, multi-thread support to the crawling tasks; (2) an extensive use of thread pool and Data Access Object (DAO) design patterns to separate persistent data storage and business logic to achieve high extendibility of the crawler tool; (3) a pattern-matching based customizable crawling algorithm to support discovery of multi-type geospatial web services; and (4) a universal and portable client-server communication mechanism combining a server-push and client pull strategies for enhanced asynchronous processing. A series of experiments were conducted to identify the impact of crawling parameters to the overall system performance. The geographical distribution pattern of all PolarHub identified services is also demonstrated. We expect this work to make a major contribution to the field of geospatial information retrieval and geospatial interoperability, to bridge the gap between data provider and data consumer, and to accelerate polar science by enhancing the accessibility and reusability of adequate polar data.

  13. Electricity hubs and market centers: A new business tool for electric utilities?

    Energy Technology Data Exchange (ETDEWEB)

    Vallen, M.A.; Sharp, L.S. [Univ. of Toledo, OH (United States)

    1995-07-01

    There are many complexities clouding the use of hubs and market centers in the electricity market, but lessons learned in the natural gas industry can save a lot of unnecessary reinvention. The bottom line: Electricity hubs and market centers will allow the markets to work most efficiently. This article will describe how regional trading hubs may function in the competitive electricity market, using the experiences of the natural gas market to illustrate the principles involved. Part I will define the typical characteristics of hubs and market centers and describe the dey success factors needed to develop a new market center. Part II will describe the types of products and services that an electricity hub or marketing center will need to offer to succeed.

  14. Logistics service sharing in supply hub in industrial park (SHIP)

    OpenAIRE

    Qiu, Xuan; 邱璇

    2013-01-01

    Industrial parks have played an indispensible role in boosting economic and industrial development. However, further development has been impeded by the shortage of land resources and by duplicate investments on common physical assets and services. This thesis proposes the concept of Supply Hub in Industrial Park (SHIP) as a public provider of warehousing and transportation services shared by manufacturing enterprises located within an industrial park. This research investigates four typic...

  15. The once & future repository, HKU's Scholars Hub

    OpenAIRE

    Palmer, DT; Castro, P.; Bollini, A; Mennielli, M

    2015-01-01

    The HKU Scholars Hub (the Hub) began service as a traditional institutional repository of The University of Hong Kong (HKU). However this format was not compelling to HKU researchers. Fortunately a subsequent reformation of the HKU statement on university mission and vision infused new life and purpose into the project. Over the next five years, in partnership with the Italian University Consortium, Cineca, the HKU Libraries transformed the Hub from an IR to a Current Research Information ...

  16. On GitHub's Programming Languages

    OpenAIRE

    2016-01-01

    GitHub is the most widely used social, distributed version control system. It has around 10 million registered users and hosts over 16 million public repositories. Its user base is also very active as GitHub ranks in the top 100 Alexa most popular websites. In this study, we collect GitHub's state in its entirety. Doing so, allows us to study new aspects of the ecosystem. Although GitHub is the home to millions of users and repositories, the analysis of users' activity time-series reveals tha...

  17. Entanglement typicality

    Science.gov (United States)

    Dahlsten, Oscar C. O.; Lupo, Cosmo; Mancini, Stefano; Serafini, Alessio

    2014-09-01

    We provide a summary of both seminal and recent results on typical entanglement. By ‘typical’ values of entanglement, we refer here to values of entanglement quantifiers that (given a reasonable measure on the manifold of states) appear with arbitrarily high probability for quantum systems of sufficiently high dimensionality. We shall focus on pure states and work within the Haar measure framework for discrete quantum variables, where we report on results concerning the average von Neumann and linear entropies as well as arguments implying the typicality of such values in the asymptotic limit. We then proceed to discuss the generation of typical quantum states with random circuitry. Different phases of entanglement, and the connection between typical entanglement and thermodynamics are discussed. We also cover approaches to measures on the non-compact set of Gaussian states of continuous variable quantum systems.

  18. Virtual Campus Hub technical evaluation report

    DEFF Research Database (Denmark)

    Vercoulen, Frank; Badger, Merete; Monaco, Lucio;

    This report describes and discusses the technical achievements of the Virtual Campus Hub project and formulates a brief agenda for the future.......This report describes and discusses the technical achievements of the Virtual Campus Hub project and formulates a brief agenda for the future....

  19. Logistics hubs: an integration of transport infrastructure

    CSIR Research Space (South Africa)

    Botha, M

    2008-07-01

    Full Text Available Logistics hubs are very well established internationally and many examples exist where these have been successfully built and implemented. This success have lead to the proliferation of such hubs and in South Africa there are many "decision makers...

  20. Theta height and Faltings height

    CERN Document Server

    Pazuki, F

    2009-01-01

    Using original ideas from J.-B. Bost and S. David, we provide an explicit comparison between the Theta height and the stable Faltings height of a principally polarized abelian variety. We also give as an application an explicit upper bound on the number of K-rational points of a curve of genus g>1 over a number filed K under a conjecture of S. Lang and J. Silverman. We complete the study with a comparison between differential lattice structures.

  1. Hub discovery in partial correlation graphical models

    CERN Document Server

    Hero, Alfred

    2011-01-01

    This paper treats the problem of screening a p-variate sample for strongly and multiply connected vertices in the partial correlation graph associated with the the partial correlation matrix of the sample. This problem, called hub screening, is important in many applications ranging from network security to computational biology to finance to social networks. In the area of network security, a node that becomes a hub of high correlation with neighboring nodes might signal anomalous activity such as a coordinated flooding attack. In the area of computational biology the set of hubs of a gene expression correlation graph can serve as potential targets for drug treatment to block a pathway or modulate host response. In the area of finance a hub might indicate a vulnerable financial instrument or sector whose collapse might have major repercussions on the market. In the area of social networks a hub of observed interactions between criminal suspects could be an influential ringleader. The techniques and theory pr...

  2. Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners.

    Directory of Open Access Journals (Sweden)

    Apurv Goel

    Full Text Available Date hub proteins have 1 or 2 interaction interfaces but many interaction partners. This raises the question of whether all partner proteins compete for the interaction interface of the hub or if the cell carefully regulates aspects of this process? Here, we have used real-time rendering of protein interaction networks to analyse the interactions of all the 1 or 2 interface hubs of Saccharomyces cerevisiae during the cell cycle. By integrating previously determined structural and gene expression data, and visually hiding the nodes (proteins and their edges (interactions during their troughs of expression, we predict when interactions of hubs and their partners are likely to exist. This revealed that 20 out of all 36 one- or two- interface hubs in the yeast interactome fell within two main groups. The first was dynamic hubs with static partners, which can be considered as 'competitive hubs'. Their interaction partners will compete for the interaction interface of the hub and the success of any interaction will be dictated by the kinetics of interaction (abundance and affinity and subcellular localisation. The second was static hubs with dynamic partners, which we term 'non-competitive hubs'. Regulatory mechanisms are finely tuned to lessen the presence and/or effects of competition between the interaction partners of the hub. It is possible that these regulatory processes may also be used by the cell for the regulation of other, non-cell cycle processes.

  3. Navicula height

    DEFF Research Database (Denmark)

    Rathleff, M; Nielsen, RG; Olesen, Christian Gammelgaard;

    2008-01-01

    position and relaxed standing posture. Excessive movement of the navicula is considered a predisposing factor in the development of shin splits. No single direct static measurement of navicula height has yet shown to predict a high degree of mid foot movement. The purpose of this study was to investigate...

  4. Wuthering Heights

    NARCIS (Netherlands)

    Bronte, Emily

    2005-01-01

    Wuthering Heights tells the story of a romance between two youngsters: Catherine Earnshaw and an orphan boy, Heathcliff. After she rejects him for a boy from a better background he develops a lust for revenge that takes over his life. In attempting to win her back and destroy those he blames for his

  5. Typical Protectionism

    Institute of Scientific and Technical Information of China (English)

    ZHANG ZHIPING

    2010-01-01

    @@ In the middle of October,acting on a complaint from the United Steelworkers union,the Office of the U.S.Trade Representative initiated a Section 301 investigation into China's clean energy policies and practices.The move has aroused strong opposition from China.China's New Energy Association says the probe is neither well-founded nor responsible,and is typical trade protectionism.

  6. Mapping Multiplex Hubs in Human Functional Brain Networks

    Science.gov (United States)

    De Domenico, Manlio; Sasai, Shuntaro; Arenas, Alex

    2016-01-01

    Typical brain networks consist of many peripheral regions and a few highly central ones, i.e., hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of specific frequency components of brain activity, present peculiar architectures with unique profiles of region centrality. However, the identification of hubs in networks built from different frequency bands simultaneously is still a challenging problem, remaining largely unexplored. Here we identify each frequency component with one layer of a multiplex network and face this challenge by exploiting the recent advances in the analysis of multiplex topologies. First, we show that each frequency band carries unique topological information, fundamental to accurately model brain functional networks. We then demonstrate that hubs in the multiplex network, in general different from those ones obtained after discarding or aggregating the measured signals as usual, provide a more accurate map of brain's most important functional regions, allowing to distinguish between healthy and schizophrenic populations better than conventional network approaches. PMID:27471443

  7. Navicula height

    DEFF Research Database (Denmark)

    Mølgaard, Carsten Møller; Olesen Gammelgaard, Christian; Nielsen, R. G.;

    2008-01-01

    In 1996 Cornwall and McPoil discovered that the static measurement of the rearfoot angle while standing on one leg in a relaxed position, could serve as a clinical indicator of the maximum amount of rearfoot eversion during walking. Due to the close relationship between midfoot and rearfoot motio...... the relationship between static measurements, using Navicual Drop Test and One Leg Standing (OLS) and the dynamic measurements of minimal navicula height loaded (NHL) and navicula drop (ΔNH)...

  8. Innovation Hub How-To

    DEFF Research Database (Denmark)

    Berger, Andreas; Brem, Alexander

    2016-01-01

    Firms around the world are eager to replicate the successes of enterprises that have established innovation labs in California's Silicon Valley. An analysis of four leading US companies that have set up idea incubators in the Valley—Xerox, Apple, Google, and Cisco—point to eight factors for succe...... disruptive over incremental innovation, and being patient. Regardless of where an innovation hub is established, the key to success lies in hiring creative, intrinsically motivated staff and then giving them the freedom to do what they do best.......Firms around the world are eager to replicate the successes of enterprises that have established innovation labs in California's Silicon Valley. An analysis of four leading US companies that have set up idea incubators in the Valley—Xerox, Apple, Google, and Cisco—point to eight factors for success...... in establishing an innovative environment: carefully considering the decision to set up such a center, hiring the right people, designing a framework for effective output, creating a buffer from bureaucratic distractions, securing a leader to champion the effort, focusing on business outcomes, fostering...

  9. The new forging process of a wheel hub drop forging

    Directory of Open Access Journals (Sweden)

    A. Gontarz

    2006-08-01

    Full Text Available Purpose: The main purpose of the research was working out a new flashless forming process of wheel hubforging in three-slide forging press (TSFP. It was assumed that the new process would be more effective thanthe forging processes applied in typical forging machines.Design/methodology/approach: The designing of the new process was based on the simulation by finiteelement method with the assumption of 3D state of strain. Calculations were made mainly for the analysis of thematerial flow kinematics and the process loads parameters. Experimental research were also made determiningthe dependency of clamping load in the function of forming load. On the basis of the analysis, the formingprocess of a wheel hub drop forging on the TSFP was worked out.Findings: The results of research confirmed the possibility of flashless forming process of wheel hub forgingin TSFP with axial cavities. The main parameters limiting the forming processes of wheel hub forgings are:permissible upsetting ratio and reciprocal relation of forming and clamping forces.Research limitations/implications: The further research within the range of determining force parameters fordifferent types of material and schemata of forming in TSFP were considered as purposeful. The works dealingwith analysis of forming processes of different types of products in order to classify drop forgings possible toform in this press will be examined.Practical implications: The comparison of the new forming process with the forging process on hammershowed majority of advantages which include: decrease of time and energy, decrease of drop forging weight andmachining, decrease of material consumption.Originality/value: The new process of wheel hub forging forming with axial cavities was worked out. Theparameters important during designing of forming processes in TSFP were provided. The relations betweenforces of forming tools were also determined.

  10. Zoning Districts - Volusia County HUB Zones

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Historically Underutilized Business (HUB) Zones in Volusia County. Go to http://www.sba.gov/hubzone or contact the Department of Economic Development (386) 248-8048...

  11. Motor coordination: a local hub for coordination.

    Science.gov (United States)

    Calabrese, Ronald L

    2014-03-31

    A local interneuron of a crayfish central pattern generator serves as a hub that integrates ascending and descending coordinating information and passes it on to a local oscillatory microcircuit to coordinate a series of segmental appendages known as swimmerets.

  12. The catheter hub disinfection cap as esophageal foreign body.

    Science.gov (United States)

    Tawfik, Kareem O; Myer, Charles M; Shikary, Tasneem; Goldschneider, Kenneth R

    2015-12-01

    Disinfection caps are increasingly being used to prevent catheter-associated bloodstream infections. These devices, designed for continuous passive disinfection of catheter hubs, are typically small and often brightly colored. As such, they have the potential to become pediatric airway and esophageal foreign bodies. We report two patients who developed esophageal foreign body following ingestion of disinfection caps. Given the increasing use of these devices, it is imperative that health care providers be aware of this potential iatrogenic problem. We propose that the use of disinfection caps may not be appropriate in pediatric patients with risk factors for foreign body ingestion.

  13. Contextual Hub Analysis Tool (CHAT): A Cytoscape app for identifying contextually relevant hubs in biological networks

    Science.gov (United States)

    Wiencko, Heather L.; Bernal-Llinares, Manuel; Bryan, Kenneth; Lynn, David J.

    2016-01-01

    Highly connected nodes (hubs) in biological networks are topologically important to the structure of the network and have also been shown to be preferentially associated with a range of phenotypes of interest. The relative importance of a hub node, however, can change depending on the biological context. Here, we report a Cytoscape app, the Contextual Hub Analysis Tool (CHAT), which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene expression or mass spectrometry data, and identify hub nodes that are more highly connected to contextual nodes (e.g. genes or proteins that are differentially expressed) than expected by chance. In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection. CHAT was used to identify and compare contextual and degree-based hubs in this network. The top 20 degree-based hubs were enriched in pathways related to the cell cycle and cancer, which is likely due to the fact that proteins involved in these processes tend to be highly connected in general. In comparison, the top 20 contextual hubs were enriched in pathways commonly observed in a viral infection including pathways related to the immune response to viral infection. This analysis shows that such contextual hubs are considerably more biologically relevant than degree-based hubs and that analyses which rely on the identification of hubs solely based on their connectivity may be biased towards nodes that are highly connected in general rather than in the specific context of interest. Availability: CHAT is available for Cytoscape 3.0+ and can be installed via the Cytoscape App Store ( http://apps.cytoscape.org/apps/chat). PMID:27853512

  14. Contextual Hub Analysis Tool (CHAT): A Cytoscape app for identifying contextually relevant hubs in biological networks.

    Science.gov (United States)

    Muetze, Tanja; Goenawan, Ivan H; Wiencko, Heather L; Bernal-Llinares, Manuel; Bryan, Kenneth; Lynn, David J

    2016-01-01

    Highly connected nodes (hubs) in biological networks are topologically important to the structure of the network and have also been shown to be preferentially associated with a range of phenotypes of interest. The relative importance of a hub node, however, can change depending on the biological context. Here, we report a Cytoscape app, the Contextual Hub Analysis Tool (CHAT), which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene expression or mass spectrometry data, and identify hub nodes that are more highly connected to contextual nodes (e.g. genes or proteins that are differentially expressed) than expected by chance. In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection. CHAT was used to identify and compare contextual and degree-based hubs in this network. The top 20 degree-based hubs were enriched in pathways related to the cell cycle and cancer, which is likely due to the fact that proteins involved in these processes tend to be highly connected in general. In comparison, the top 20 contextual hubs were enriched in pathways commonly observed in a viral infection including pathways related to the immune response to viral infection. This analysis shows that such contextual hubs are considerably more biologically relevant than degree-based hubs and that analyses which rely on the identification of hubs solely based on their connectivity may be biased towards nodes that are highly connected in general rather than in the specific context of interest.

  15. Collaborative Data Analytics with DataHub.

    Science.gov (United States)

    Bhardwaj, Anant; Karger, David; Subramanyam, Harihar; Deshpande, Amol; Madden, Sam; Wu, Eugene; Elmore, Aaron; Parameswaran, Aditya; Zhang, Rebecca

    2015-08-01

    While there have been many solutions proposed for storing and analyzing large volumes of data, all of these solutions have limited support for collaborative data analytics, especially given the many individuals and teams are simultaneously analyzing, modifying and exchanging datasets, employing a number of heterogeneous tools or languages for data analysis, and writing scripts to clean, preprocess, or query data. We demonstrate DataHub, a unified platform with the ability to load, store, query, collaboratively analyze, interactively visualize, interface with external applications, and share datasets. We will demonstrate the following aspects of the DataHub platform: (a) flexible data storage, sharing, and native versioning capabilities: multiple conference attendees can concurrently update the database and browse the different versions and inspect conflicts; (b) an app ecosystem that hosts apps for various data-processing activities: conference attendees will be able to effortlessly ingest, query, and visualize data using our existing apps; (c) thrift-based data serialization permits data analysis in any combination of 20+ languages, with DataHub as the common data store: conference attendees will be able to analyze datasets in R, Python, and Matlab, while the inputs and the results are still stored in DataHub. In particular, conference attendees will be able to use the DataHub notebook - an IPython-based notebook for analyzing data and storing the results of data analysis.

  16. Supervised hub-detection for brain connectivity

    Science.gov (United States)

    Kasenburg, Niklas; Liptrot, Matthew; Reislev, Nina Linde; Garde, Ellen; Nielsen, Mads; Feragen, Aasa

    2016-03-01

    A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied, but can smooth discriminative signals in the population, degrading predictive performance. We present a novel hub-detection optimized for supervised learning that both clusters network nodes based on population level variation in connectivity and also takes the learning problem into account. The found hubs are a low-dimensional representation of the network and are chosen based on predictive performance as features for a linear regression. We apply our method to the problem of finding age-related changes in structural connectivity. We compare our supervised hub-detection (SHD) to an unsupervised hub-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any network regression problem. Further development of the presented algorithm will be the extension to other predictive models such as classification or non-linear regression.

  17. Hub Status and Indexation of Container Ports

    Directory of Open Access Journals (Sweden)

    Yong-An Park

    2015-06-01

    This study develops two sub-indexes of port classification and capacity, and combines cases of these two sub-indexes into various types in order to find a proper port hub index. The paper demonstrates how different types of port hub index are useful measurements for evaluating outputs and inputs of container ports. In a case analysis we show that the indexes of period variables and lagged variables have more explanatory power with regard to changes of port throughputs and high correlation with inputs.

  18. Forecasting Beijing Transportation Hub Areas’s Pedestrian Flow Using Modular Neural Network

    Directory of Open Access Journals (Sweden)

    Shuwei Wang

    2015-01-01

    Full Text Available Along with the increasing proportion of urban public transportation trip, pedestrian flow in transportation hub areas increased. For effectively improving the emergency handling ability of related management apartments and preventing the incident of pedestrian congestion, this paper studied the method of pedestrian flow forecast in Beijing transportation hub areas. Firstly, 34 typical sidewalks in Beijing transportation hub areas were surveyed to obtain 2200 valid data. Secondly, correlation analysis was used to analyze the relationship between pedestrian flow and its influential factors. 11 significant influential factors were extracted. Thirdly, forecasting model was established with modular neural network. The surveyed pedestrian flow sample was fuzzy clustered according to the regional land use where the transportation hub existed. Then, membership function based on the distance measure was constructed. Through fuzzy discrimination, online selection for the subnetwork of the information can be achieved. Consequently, the self-adaptation of the neural network on information processing was improved. Finally, this paper tested the pedestrian flow sample of a transportation hub in Beijing. It was concluded that the accuracy of pedestrian flow forecasting model using modular neural network was higher than other neural network models. There was also improvement in the adaptability to environment.

  19. Exploring hubness in Regional Trade Agreements

    NARCIS (Netherlands)

    Vaal, A. de

    2016-01-01

    In the plethora of Regional Trade Agreements (RTAs) some countries take in a more central position than others in the sense that some countries are much more engaged with other countries through RTAs. Furthermore, the position of some countries is that of a hub: they have (many) trade

  20. Hub location problems in transportation networks

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Nickel, Stefan

    2011-01-01

    In this paper we propose a 4-index formulation for the uncapacitated multiple allocation hub location problem tailored for urban transport and liner shipping network design. This formulation is very tight and most of the tractable instances for MIP solvers are optimally solvable at the root node....... also introduce fixed cost values for Australian Post (AP) dataset....

  1. Optimising steel hub location in Thailand

    Directory of Open Access Journals (Sweden)

    Sakaradhorn Boontaveeyuwat

    2012-11-01

    Full Text Available The optimal location of a steel hub in Thailand was analysed by applying aspecific research methodology designed to evaluate locations near the seaports. The growth of Thailand’s steel industry has become a centre of attention in the last decade, resulting in substantial efforts to form a distribution service centre to minimise the logistic costs associated with handling large steel flows in the future. The main analysis of the steel hublocation focused on areas situated near Laem Cha Bang, Map Ta Phut and Prachuab ports since these top three ports are considered important in terms of their steel throughput in Thailand. The transport costs associated with the shipment and inland transport together with port tariffs were calculated for the proposed scenarios of steel hub establishment andthese were compared with the existing situation without steel hub. The findings showed that a steel hub located near Laem Cha Bang port was the optimal option involving a saving of 9.4% on the total system costs incurred under the existing situation.

  2. A State Cyber Hub Operations Framework

    Science.gov (United States)

    2016-06-01

    level cyber operations from state information technology (IT) and network infrastructure to hospitals , commercial banking, and manufacturing the...tools - TTPs necessary to operate and maintain Authoritative Data Repository for operational related artifacts . - Monitor and report on operations...development of Data Repository structures to enable storage of Cyber Hub related artifacts . - Provides Technical input to Business Case Analyses (BCAs

  3. Constructing Hongqiao Hub and Serving Regional Economy:Planning and Operation of Hongqiao Comprehensive Transportation Hub

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Taking Hongqiao Integrated Transportation Hub Project as a case, this paper introduces its origin, orientation, development programming, planning and design, road planning, information system planning, air-rail integrated transportation planning, disaster prevention planning, and so on.

  4. Southwest Regional Climate Hub and California Subsidiary Hub assessment of climate change vulnerability and adaptation and mitigation strategies

    Science.gov (United States)

    Emile Elias; Caiti Steele; Kris Havstad; Kerri Steenwerth; Jeanne Chambers; Helena Deswood; Amber Kerr; Albert Rango; Mark Schwartz; Peter Stine; Rachel Steele

    2015-01-01

    This report is a joint effort of the Southwest Regional Climate Hub and the California Subsidiary Hub (Sub Hub). The Southwest Regional Climate Hub covers Arizona, California, Hawai‘i and the U.S. affiliated Pacific Islands, Nevada, New Mexico, and Utah and contains vast areas of western rangeland, forests, and high-value specialty crops (Figure 1). The California Sub...

  5. Extension of Goldstein's circulation function for optimal rotors with hub

    DEFF Research Database (Denmark)

    Okulov, Valery; Sørensen, Jens Nørkær; Shen, Wen Zhong

    2016-01-01

    The aerodynamic interaction or interference between rotor blades and hub body is usually very complicated, but some useful simplifications can be made by considering the hub with an infinite cylinder. Various attempts to find the optimum distribution of circulation by the lifting vortex lines...... method have been previously proposed to describe the blade interaction with the hub modeled by the infinite cylinder. In this case, the ideal distribution of bound circulation on the rotor blades is such that the shed vortex system in the hub-area is a set of helicoidal vortex sheets moving uniformly...... at the nose-area of the semi-infinite hub....

  6. Developmental Changes in Brain Network Hub Connectivity in Late Adolescence.

    Science.gov (United States)

    Baker, Simon T E; Lubman, Dan I; Yücel, Murat; Allen, Nicholas B; Whittle, Sarah; Fulcher, Ben D; Zalesky, Andrew; Fornito, Alex

    2015-06-17

    The human brain undergoes substantial development throughout adolescence and into early adulthood. This maturational process is thought to include the refinement of connectivity between putative connectivity hub regions of the brain, which collectively form a dense core that enhances the functional integration of anatomically distributed, and functionally specialized, neural systems. Here, we used longitudinal diffusion magnetic resonance imaging to characterize changes in connectivity between 80 cortical and subcortical anatomical regions over a 2 year period in 31 adolescents between the ages of 15 and 19 years. Connectome-wide analysis indicated that only a small subset of connections showed evidence of statistically significant developmental change over the study period, with 8% and 6% of connections demonstrating decreased and increased structural connectivity, respectively. Nonetheless, these connections linked 93% and 90% of the 80 regions, respectively, pointing to a selective, yet anatomically distributed pattern of developmental changes that involves most of the brain. Hub regions showed a distinct tendency to be highly connected to each other, indicating robust "rich-club" organization. Moreover, connectivity between hubs was disproportionately influenced by development, such that connectivity between subcortical hubs decreased over time, whereas frontal-subcortical and frontal-parietal hub-hub connectivity increased over time. These findings suggest that late adolescence is characterized by selective, yet significant remodeling of hub-hub connectivity, with the topological organization of hubs shifting emphasis from subcortical hubs in favor of an increasingly prominent role for frontal hub regions.

  7. Spatial Economic Hubs and State Power

    Institute of Scientific and Technical Information of China (English)

    Xuan Xingzhang; Huang Jing

    2008-01-01

    The paper seeks to analyze the rise of state power in the light of spatial economic shifts and examines the historical context of China's rise and challenges facing it. In world history, only countries that were spatial economic hubs have been able to enjoy prosperity over centuries. China is not yet such a country, despite its persistent efforts. Nor is China likely to become an economic hub in the foreseeable future. China is under mounting pressure from new economic demands posed by shifts in the geo-economic status of the U.S.. The fact that the global economy thrives along coastlines also causes problems for China, a country with a long coastline and a vast hinterland, creating rifts between northern and southern China, central and local governments, and different provinces. All these factors might well hinder China's development in the future.

  8. Topographic hub maps of the human structural neocortical network.

    Directory of Open Access Journals (Sweden)

    Emil H J Nijhuis

    Full Text Available Hubs within the neocortical structural network determined by graph theoretical analysis play a crucial role in brain function. We mapped neocortical hubs topographically, using a sample population of 63 young adults. Subjects were imaged with high resolution structural and diffusion weighted magnetic resonance imaging techniques. Multiple network configurations were then constructed per subject, using random parcellations to define the nodes and using fibre tractography to determine the connectivity between the nodes. The networks were analysed with graph theoretical measures. Our results give reference maps of hub distribution measured with betweenness centrality and node degree. The loci of the hubs correspond with key areas from known overlapping cognitive networks. Several hubs were asymmetrically organized across hemispheres. Furthermore, females have hubs with higher betweenness centrality and males have hubs with higher node degree. Female networks have higher small-world indices.

  9. Extension of Goldstein's circulation function for optimal rotors with hub

    Science.gov (United States)

    Okulov, V. L.; Sørensen, J. N.; Shen, W. Z.

    2016-09-01

    The aerodynamic interaction or interference between rotor blades and hub body is usually very complicated, but some useful simplifications can be made by considering the hub with an infinite cylinder. Various attempts to find the optimum distribution of circulation by the lifting vortex lines method have been previously proposed to describe the blade interaction with the hub modeled by the infinite cylinder. In this case, the ideal distribution of bound circulation on the rotor blades is such that the shed vortex system in the hub-area is a set of helicoidal vortex sheets moving uniformly as if rigid, exactly as in the case where there is no influence of the streamtube deformations by the central hub-body. In the present investigation, we consider a more specific problem of the rotor-hub interaction where the initial flow streamtubes and the rotor slipstream submitted strong deformations at the nose-area of the semi-infinite hub.

  10. Ranking hubs and authorities using matrix functions

    OpenAIRE

    2012-01-01

    The notions of subgraph centrality and communicability, based on the exponential of the adjacency matrix of the underlying graph, have been effectively used in the analysis of undirected networks. In this paper we propose an extension of these measures to directed networks, and we apply them to the problem of ranking hubs and authorities. The extension is achieved by bipartization, i.e., the directed network is mapped onto a bipartite undirected network with twice as many nodes in order to ob...

  11. Developing Istanbul into a Regional Business Hub

    Science.gov (United States)

    2004-12-01

    beds). Every year Istanbul hosts people from all around the world for international summits, conferences, film and music festivals and sports...Kong, Taiwan, Malaysia , Thailand, and the Philippines are positioning themselves to be logistics hubs. On the other hand, in Eastern Europe; Czech...close to nearby major markets of the world, are only some of Turkey’s many advantages. 2. Istanbul Throughout history , Istanbul has been a city at the

  12. Biaxial wheel/hub test facility. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, G.; Grubisic, V. [eds.

    2000-07-01

    The 4{sup th} meeting aims to exchange the experience and knowledge of engineers during several presentations and discussions about new developments required for a reliable, time and cost reducing validation of the wheel/hub assembly. Tremendous development of the wheel performance, described by the ratio of the rated load (kg) versus the wheel weight (kg) had taken place during the last 5000 years. Starting from the ratio of 3 for wooden 2-piece-disc-wheels in Mesopotamia it needed nearly 1000 years to increase the ratio to approx 5 at light-weight spoke wheels for fighting carriages, found in the grave of king Tutenchamon in Egypt. Modern light alloy wheels of commercial vehicles reach values up to 160 kg/kg. Additionally the comlex design of the modern systems for cars and commercial vehicles comprising wheel, brake, hub, bearing, spindle and hub carrier, including different materials and their treatment, fasteners, press-fits, require an appropriate testing procedure. The variable loading conditions, caused by operational wheel forces, brake and torque moments including heating, may result in changing tolerances and press-fits during operation and consequently in different damage mechanisms. This can be simulated in the Biaxial Wheel Test Machine, whereby corresponding load programs are necessary. An overview about all biaxial test machines in usage at the end of 1999 is shown in the introduction. The total number is 17 for cars, 7 for commercial vehicles and 1 for trains. The six presentations of this meeting were consequently concentrated on: (a) recommendations for a standardization of load programs of the German Wheel Committee, (b) the simulation of brake and torque events and (c) the possibility for a numerical stress analyses and fatigue life assessment. (orig./AKF)

  13. Supervised hub-detection for brain connectivity

    DEFF Research Database (Denmark)

    Kasenburg, Niklas; Liptrot, Matthew George; Reislev, Nina Linde

    2016-01-01

    A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied......-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any...

  14. An Introduction to Version Control Using GitHub Desktop

    Directory of Open Access Journals (Sweden)

    Daniel van Strien

    2016-06-01

    Full Text Available In this lesson you will be introduced to the basics of version control, understand why it is useful and implement basic version control for a plain text document using GitHub Desktop. By the end of this lesson you should understand: * what version control is and why it can be useful * the differences between Git and GitHub * how to implement version control using ‘GitHub Desktop,’ a Graphical User Interface for GitHub * be aware of other resources that will help you implement version control in your academic writing

  15. An Introduction to Version Control Using GitHub Desktop

    OpenAIRE

    Daniel van Strien

    2016-01-01

    In this lesson you will be introduced to the basics of version control, understand why it is useful and implement basic version control for a plain text document using GitHub Desktop. By the end of this lesson you should understand: * what version control is and why it can be useful * the differences between Git and GitHub * how to implement version control using ‘GitHub Desktop,’ a Graphical User Interface for GitHub * be aware of other resources that will help you imple...

  16. Fear of heights and visual height intolerance.

    Science.gov (United States)

    Brandt, Thomas; Huppert, Doreen

    2014-02-01

    The aim of this review is, first, to cover the different aspects of visual height intolerance such as historical descriptions, definition of terms, phenomenology of the condition, neurophysiological control of gaze, stance and locomotion, and therapy, and, second, to identify warranted epidemiological and experimental studies. Vivid descriptions of fear of heights can be found in ancient texts from the Greek, Roman, and Chinese classics. The life-time prevalence of visual height intolerance is as high as 28% in the general population, and about 50% of those who are susceptible report an impact on quality of life. When exposed to heights, visual exploration by eye and head movements is restricted, and the velocity of locomotion is reduced. Therapy for fear of heights is dominated by the behavioral techniques applied during real or virtual reality exposure. Their efficacy might be facilitated by the administration of D-cycloserine or glucocorticoids. Visual height intolerance has a considerable impact on daily life and interpersonal interactions. It is much more frequent than fear of heights, which is defined as an environmental subtype of a specific phobia. There is certainly a continuum stretching from acrophobia to a less-pronounced visual height intolerance, to which the categorical distinction of a specific phobia does not apply.

  17. Brief communication "Spatial and temporal variation of wind power at hub height over Europe"

    Directory of Open Access Journals (Sweden)

    S. Gisinger

    2013-05-01

    Full Text Available Wind power over Europe computed from two years of the new 100 m wind product from ECMWF at 16 km horizontal resolution is 20% of maximum capacity of an exemplary wind turbine power curve. This is five percent of maximum capacity less than extrapolated from 10 m winds using model roughness in the logarithmic law, but eight percent more than multiplying 10 m winds by a constant factor of 1.28 as in a previous study. The result from the new data set happens to be very close to the actual capacity factor of 21% for European wind turbines (Boccard, 2009. The capacity factor in high power regions between 50 and 58° N and most of northernmost Africa is almost 30%. The aggregation of wind power over Europe smooths onshore day-to-day fluctuations to at most 7 percentage points during 80% of the year.

  18. Liner Shipping Hub Network Design in a Competitive Environment

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Nickel, Stefan; Pisinger, David

    A new mixed integer programming formulation is proposed for hub-and-spoke network design in a competitive environment. It addresses competition between a newcomer liner service provider and an alliance, both operating on hub-and-spoke networks. The newcomer company maximizes its market share...

  19. Liner shipping hub network design in a competitive environment

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Nickel, Stefan; Pisinger, David

    2010-01-01

    A mixed integer programming formulation is proposed for hub-and-spoke network design in a competitive environment. It addresses the competition between a newcomer liner service provider and an existing dominating operator, both operating on hub-and-spoke networks. The newcomer company maximizes its...

  20. International Education Hubs: Collaboration for Competitiveness and Sustainability

    Science.gov (United States)

    Knight, Jane

    2014-01-01

    This chapter focuses on the development of education hubs, a recent phenomenon in international higher education. Three models of hubs are examined in relation to the forces, risks, and opportunities of globalization and how local and international collaborations are essential for both global competitiveness and sustainability.

  1. Soft Power and Cultural Diplomacy: Emerging Education Hubs in Asia

    Science.gov (United States)

    Lee, Jack T.

    2015-01-01

    Several education hubs have emerged in Asia and the Middle East in recent years with a specific focus on cross-border higher education. Through considerable efforts in policy planning and generous funding, these hubs aim to transform a country or city into an eminent destination for education, research, and training. The inherent design of these…

  2. Optimal Model and Solution of Railway Hub Shift Working Plan

    Institute of Scientific and Technical Information of China (English)

    He Shiwei; Zhu Songnian; Lin Boliang

    1996-01-01

    Aiming at decreasing the hub transportation costs, a railway hub shift working plan in terms of multicommodity network flow model is set up for considering the coordination of freight working, train working and locomotive working plans. The solution and the calculating results are also introduced.

  3. Phased arrays: inline flow line hub inspection using phased arrays

    NARCIS (Netherlands)

    Bloom, J.G.P.; Chougrani, K.; Rundberg, H.; Oldenziel, G.; Deleye, X.; Martina, Q.

    2011-01-01

    The feasibility of the inspection of flow line hubs using the phased array technique was investigated to determine the surface area of the seal area degraded by corrosion. A clean model of the hub was simulated to gain insight into the geometrical echoes and to determine the area covered by the ultr

  4. A versatile framework for cooperative hub network development

    NARCIS (Netherlands)

    Cruijssen, F.C.A.M.; Borm, P.; Dullaert, W.; Hamers, H.

    2010-01-01

    This paper introduces a framework for cooperative hub network development. Building a joint physical hub for the transshipment of goods is expensive and, therefore, involves considerable risks for cooperating companies. In a practical setting, it is unlikely that an entire network will be built at o

  5. Education Hubs: A Fad, a Brand, an Innovation?

    Science.gov (United States)

    Knight, Jane

    2011-01-01

    The last decade has seen significant changes in all aspects of internationalization but most dramatically in the area of education and research moving across national borders. The most recent developments are education hubs. The term "education hub" is being used by countries who are trying to build a critical mass of local and foreign…

  6. Soft Power and Cultural Diplomacy: Emerging Education Hubs in Asia

    Science.gov (United States)

    Lee, Jack T.

    2015-01-01

    Several education hubs have emerged in Asia and the Middle East in recent years with a specific focus on cross-border higher education. Through considerable efforts in policy planning and generous funding, these hubs aim to transform a country or city into an eminent destination for education, research, and training. The inherent design of these…

  7. Climate programs update: USDA Southwest Regional Climate Hub update

    Science.gov (United States)

    PROGRAM OVERVIEW: The overarching goal of the USDA SW Climate Hub is to assist farmers, ranchers and foresters in addressing the effects of climate change including prolonged drought, increased insect outbreaks and severe wildfires. In the first year of operations, the SW Climate Hub (est. Februa...

  8. Liner shipping hub network design in a competitive environment

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Nickel, Stefan; Pisinger, David

    2010-01-01

    A mixed integer programming formulation is proposed for hub-and-spoke network design in a competitive environment. It addresses the competition between a newcomer liner service provider and an existing dominating operator, both operating on hub-and-spoke networks. The newcomer company maximizes i...

  9. International Education Hubs: Collaboration for Competitiveness and Sustainability

    Science.gov (United States)

    Knight, Jane

    2014-01-01

    This chapter focuses on the development of education hubs, a recent phenomenon in international higher education. Three models of hubs are examined in relation to the forces, risks, and opportunities of globalization and how local and international collaborations are essential for both global competitiveness and sustainability.

  10. The 4 Pi Sky Transient Alerts Hub

    CERN Document Server

    Staley, Tim D

    2016-01-01

    We introduce the 4 Pi Sky 'hub', a collection of open data-services and underlying software packages built for rapid, fully automated reporting and response to astronomical transient alerts. These packages build on the mature 'VOEvent' standardized message-format, and aim to provide a decentralized and open infrastructure for handling transient alerts. In particular we draw attention to the initial release of voeventdb, an archive and remote-query service that allows astronomers to make historical queries about transient alerts. By employing spatial filters and web-of-citation lookups, voeventdb enables cross-matching of transient alerts to bring together data from multiple sources, as well as providing a point of reference when planning new follow-up campaigns. We also highlight the recent addition of optical-transient feeds from the ASASSN and GAIA projects to our VOEvent distribution stream. Both the source-code and deployment-scripts which implement these services are freely available and permissively lic...

  11. Location of Urban Logistic Terminals as Hub Location Problem

    Directory of Open Access Journals (Sweden)

    Jasmina Pašagić Škrinjar

    2012-09-01

    Full Text Available In this paper the problems of locating urban logistic terminals are studied as hub location problems that due to a large number of potential nodes in big cities belong to hard non-polynomial problems, the so-called NP-problems. The hub location problems have found wide application in physical planning of transport and telecommunication systems, especially systems of fast delivery, networks of logistic and distribution centres and cargo traffic terminals of the big cities, etc. The paper defines single and multiple allocations and studies the numerical examples. The capacitated single allocation hub location problems have been studied, with the provision of a mathematical model of selecting the location for the hubs on the network. The paper also presents the differences in the possibilities of implementing the exact and heuristic methods to solve the actual location problems of big dimensions i.e. hub problems of the big cities.

  12. [Height vertigo, fear of heights, acrophobia].

    Science.gov (United States)

    Rennert, H

    1990-06-01

    Height vertigo (acrophobia) is a very frequent phenomenon being of interest for its physiological and psychological background, though usually only of limited significance in neuropsychiatry and otology. The different aspects as to its nature and origin are discussed. If acrophobia has developed into a conditioned reaction of avoidance with pressure of suffering, or acrophobia in persons, who have to work at heights, behavior therapeutic measures with systematic desensibilisation, starting from an imaginative training, are indicated.

  13. Hub exchange operations in intermodal hub-and spoke networks : a performance comparison of rail-rail exchange facilities

    NARCIS (Netherlands)

    Bontekoning, Y.M.

    2006-01-01

    The implementation of hub-and-spoke networks in intermodal transport is suggested as one of the potential solutions for helping to increase the intermodal market share. Traditionally, trains are shunted at hubs; this is a time-consuming process. Since the early 1990s a new type of intermodal termina

  14. Flow Merging and Hub Route Optimization in Collaborative Transportation

    Directory of Open Access Journals (Sweden)

    Kerui Weng

    2014-01-01

    Full Text Available This paper studies the optimal hub routing problem of merged tasks in collaborative transportation. This problem allows all carriers’ transportation tasks to reach the destinations optionally passing through 0, 1, or 2 hubs within limited distance, while a cost discount on arcs in the hub route could be acquired after paying fixed charges. The problem arises in the application of logistics, postal services, airline transportation, and so forth. We formulate the problem as a mixed-integer programming model, and provide two heuristic approaches, respectively, based on Lagrangian relaxation and Benders decomposition. Computational experiments show that the algorithms work well.

  15. GitHub open source project recommendation system

    OpenAIRE

    Matek, Tadej; Zebec, Svit Timej

    2016-01-01

    Hosting platforms for software projects can form collaborative social networks and a prime example of this is GitHub which is arguably the most popular platform of this kind. An open source project recommendation system could be a major feature for a platform like GitHub, enabling its users to find relevant projects in a fast and simple manner. We perform network analysis on a constructed graph based on GitHub data and present a recommendation system that uses link prediction.

  16. The Opportunities and Threats of Turning Airports into Hubs

    Science.gov (United States)

    Kraus, Andreas; Koch, Benjamin

    2006-01-01

    This paper examines the opportunities and threats which arise when turning origin/destination airports into hubs. The analysis focuses on market development trends, competitive structures, especially in the light of airline network strategies and the growing rivalry between airports, and finally the potential financial impacts for the airport, including both investment efforts and the financial results from hub operations. We argue that in most cases a decision against converting a traditional origin/destination airport into a major transfer point is preferable to the transformation into a hub.

  17. A Hedonism Hub in the Human Brain

    Science.gov (United States)

    Zacharopoulos, G.; Lancaster, T. M.; Bracht, T.; Ihssen, N.; Maio, G. R.; Linden, D. E. J.

    2016-01-01

    Human values are abstract ideals that motivate behavior. The motivational nature of human values raises the possibility that they might be underpinned by brain structures that are particularly involved in motivated behavior and reward processing. We hypothesized that variation in subcortical hubs of the reward system and their main connecting pathway, the superolateral medial forebrain bundle (slMFB) is associated with individual value orientation. We conducted Pearson's correlation between the scores of 10 human values and the volumes of 14 subcortical structures and microstructural properties of the medial forebrain bundle in a sample of 87 participants, correcting for multiple comparisons (i.e.,190). We found a positive association between the value that people attach to hedonism and the volume of the left globus pallidus (GP).We then tested whether microstructural parameters (i.e., fractional anisotropy and myelin volume fraction) of the slMFB, which connects with the GP, are also associated to hedonism and found a significant, albeit in an uncorrected level, positive association between the myelin volume fraction within the left slMFB and hedonism scores. This is the first study to elucidate the relationship between the importance people attach to the human value of hedonism and structural variation in reward-related subcortical brain regions. PMID:27473322

  18. Idea Hubs as Nexus of Collective Creativity in Digital Innovation

    DEFF Research Database (Denmark)

    Ciriello, Raffaele; Richter, Alexander

    2015-01-01

    on instances of idea hubs in two multinational European software companies, where we conducted a case study over a two-year period, and collected data in form of interviews, digital documents, and participant observations. In doing so, we identify a set of social networking practices in which idea hubs serve......Digital innovation radically transforms the nature of corporate innovation practices, implying a growing need for deeper understanding its origins and outcomes. In this paper, we conceptualize the focal points of social networking in digital innovation as idea hubs. We focus our analysis...... as nexus of collective creativity and subject these to a critical dialectical examination. We discuss three influencing factors of idea hub choice, namely material infrastructure, innovation process phase, and personal characteristics. These explain why in a corporate environment, despite a variety...

  19. 14 CFR 398.2 - Number and designation of hubs.

    Science.gov (United States)

    2010-01-01

    ... origin and designation data; (iv) The distance of candidate hubs from the eligible place; and (v) The... may instead require that service from an eligible place be provided to a nearby focal point...

  20. Model of Controlling the Hubs in P2P Networks

    Directory of Open Access Journals (Sweden)

    Yuhua Liu

    2009-06-01

    Full Text Available Research into the hubs in Peer-to-Peer (P2P networks, and present a new method to avoid generating the hubs in the networks by controlling the logical topology structure of P2P networks. We firstly introduce the controlling ideas about hierarchizing the hubs. Then, we disclose and interpret the controlling model, and give out the concrete method to carry it out. Finally, we validate our controlling model via simulations and the simulation results demonstrate that our work is effective to control the hubs in P2P networks. Thus, this model can improve the network competence to defend against coordinated attacks, promote the network robustness, and ensure the network would develop continually and healthily.

  1. A Flexible Logistics Distribution Hub Model considering Cost Weighted Time

    Directory of Open Access Journals (Sweden)

    Wenxue Ran

    2017-01-01

    Full Text Available The delivery time of order has become an important fact for customers to evaluate logistics services. Due to the diverse and large quantities of orders in the background of electronic commerce, how to improve the flexibility of distribution hub and reduce the waiting time of customers becomes one of the most challenging questions for logistics companies. With this in mind, this paper proposes a new method of flexibility assessment in distribution hub by introducing cost weighted time (CWT. The advantages of supply hub operation mode in delivery flexibility are verified by the approach: the mode has pooling effects and uniform distribution characteristics; these traits can reduce overlapping delivery time to improve the flexibility in the case of two suppliers. Numerical examples show that the supply hub operation mode is more flexible than decentralized distribution operation mode in multidelivery cycles.

  2. Establishing a Global Halal Hub: In-Depth Interviews

    Directory of Open Access Journals (Sweden)

    Mahdi Borzooei

    2013-10-01

    Full Text Available The purpose of this study is to explore the requirements needed for a country to establish itself as a global Halal hub. In this regard, this exploratory research paper uses a semi-structured in-depth interview to obtain the perceptions of Halal experts about the requirements for establishing a Halal hub. The results of the study indicate that human capital, media, research and development, events, country’s capability, public and governmental support, marketing strategy, and infrastructure comprise the vital requirements. Furthermore, from the perceptions of the experts, public and governmental support, marketing strategy, and human capital are the three most important requirements. Since this paper is an exploratory study, it provides some insights of the three experts on the establishing of a Halal hub. In addition, a quantitative study is an appropriate approach to implement the findings of this study empirically and to determine the effective components to establish a Halal hub in those countries that desire it. A practical implication of this study is the opening of a new window for any country that aspires to be a Halal hub. In this matter, this paper presents the key considerations in establishing a Halal hub for Halal certification bodies, companies and marketers involved in the Halal business. Moreover, this research attempts to influence the perceptions and attitudes of people of the country on the desirability of becoming a Halal hub, followed by a discussion on the development of a national brand. When the contribution of its people is high, a country stands the best chance of achieving its goal. Finally, this study is one of the first to seek the perceptions of experts about vital requirements that a country should pay more attention to if it wishes to establish a global Halal hub.

  3. A Hub Matrix Theory and Applications to Wireless Communications

    Directory of Open Access Journals (Sweden)

    Kung HT

    2007-01-01

    Full Text Available This paper considers communications and network systems whose properties are characterized by the gaps of the leading eigenvalues of for a matrix . It is shown that a sufficient and necessary condition for a large eigen-gap is that is a "hub" matrix in the sense that it has dominant columns. Some applications of this hub theory in multiple-input and multiple-output (MIMO wireless systems are presented.

  4. Why do European companies have Innovation Hubs in Silicon Valley

    DEFF Research Database (Denmark)

    Berger, Andreas; Brem, Alexander

    2017-01-01

    Innovation hubs are gaining high attention in recent years, especially from European companies. Silicon Valley has been deemed as one of the most attractive and successful environments for establishing innovation hubs. This article highlights examples of companies from Europe that made the step t...... to California—namely, Volkswagen, Swisscom, BMW, Axel Springer, Munich Re, and Innogy SE (RWE Group). Based on these companies’ experiences, recommendations are given on how companies might approach a setup in Silicon Valley for long-term success....

  5. Concerted perturbation observed in a hub network in Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Dapeng Liang

    Full Text Available Alzheimer's disease (AD is a progressive neurodegenerative disease involving the alteration of gene expression at the whole genome level. Genome-wide transcriptional profiling of AD has been conducted by many groups on several relevant brain regions. However, identifying the most critical dys-regulated genes has been challenging. In this work, we addressed this issue by deriving critical genes from perturbed subnetworks. Using a recent microarray dataset on six brain regions, we applied a heaviest induced subgraph algorithm with a modular scoring function to reveal the significantly perturbed subnetwork in each brain region. These perturbed subnetworks were found to be significantly overlapped with each other. Furthermore, the hub genes from these perturbed subnetworks formed a connected hub network consisting of 136 genes. Comparison between AD and several related diseases demonstrated that the hub network was robustly and specifically perturbed in AD. In addition, strong correlation between the expression level of these hub genes and indicators of AD severity suggested that this hub network can partially reflect AD progression. More importantly, this hub network reflected the adaptation of neurons to the AD-specific microenvironment through a variety of adjustments, including reduction of neuronal and synaptic activities and alteration of survival signaling. Therefore, it is potentially useful for the development of biomarkers and network medicine for AD.

  6. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden

    Science.gov (United States)

    Drzezga, Alexander; Van Dijk, Koene R. A.; Sreenivasan, Aishwarya; Talukdar, Tanveer; Sullivan, Caroline; Schultz, Aaron P.; Sepulcre, Jorge; Putcha, Deepti; Greve, Doug; Johnson, Keith A.; Sperling, Reisa A.

    2011-01-01

    Disruption of functional connectivity between brain regions may represent an early functional consequence of β-amyloid pathology prior to clinical Alzheimer's disease. We aimed to investigate if non-demented older individuals with increased amyloid burden demonstrate disruptions of functional whole-brain connectivity in cortical hubs (brain regions typically highly connected to multiple other brain areas) and if these disruptions are associated with neuronal dysfunction as measured with fluorodeoxyglucose-positron emission tomography. In healthy subjects without cognitive symptoms and patients with mild cognitive impairment, we used positron emission tomography to assess amyloid burden and cerebral glucose metabolism, structural magnetic resonance imaging to quantify atrophy and novel resting state functional magnetic resonance imaging processing methods to calculate whole-brain connectivity. Significant disruptions of whole-brain connectivity were found in amyloid-positive patients with mild cognitive impairment in typical cortical hubs (posterior cingulate cortex/precuneus), strongly overlapping with regional hypometabolism. Subtle connectivity disruptions and hypometabolism were already present in amyloid-positive asymptomatic subjects. Voxel-based morphometry measures indicate that these findings were not solely a consequence of regional atrophy. Whole-brain connectivity values and metabolism showed a positive correlation with each other and a negative correlation with amyloid burden. These results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical onset of dementia. The spatial overlap between hypometabolism and disruption of connectivity in cortical hubs points to a particular susceptibility of these regions to early Alzheimer's-type neurodegeneration and may reflect a link between synaptic dysfunction and functional

  7. Identification of promising Twin Hub networks: Report of Work Package 1 of the Intermodal rail freight Twin hub Network Northwest Europe - project (final report)

    NARCIS (Netherlands)

    Kreutzberger, E.D.; Konings, J.W.; Meijer, S.; Witteveen, C.; Meijers, B.M.; Pekin, E.; Macharis, C.; Kiel, J.; Kawabata, Y.; Vos, W.

    2014-01-01

    This report is the first deliverable of the project Intermodal Rail Freight Twin Hub Network Northwest Europe. We call its subject Twin hub network and the organisational entity to carry out the actions the Twin hub project. The project is funded by INTERREG NWE (programme IVb). Its work started in

  8. Why Do Hubs Tend to Be Essential in Protein Networks?

    Directory of Open Access Journals (Sweden)

    2006-06-01

    Full Text Available The protein-protein interaction (PPI network has a small number of highly connected protein nodes (known as hubs and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centrality-lethality rule. This rule is widely believed to reflect the special importance of hubs in organizing the network, which in turn suggests the biological significance of network architectures, a key notion of systems biology. Despite the popularity of this explanation, the underlying cause of the centrality-lethality rule has never been critically examined. We here propose the concept of essential PPIs, which are PPIs that are indispensable for the survival or reproduction of an organism. Our network analysis suggests that the centrality-lethality rule is unrelated to the network architecture, but is explained by the simple fact that hubs have large numbers of PPIs, therefore high probabilities of engaging in essential PPIs. We estimate that ~ 3% of PPIs are essential in the yeast, accounting for ~ 43% of essential genes. As expected, essential PPIs are evolutionarily more conserved than nonessential PPIs. Considering the role of essential PPIs in determining gene essentiality, we find the yeast PPI network functionally more robust than random networks, yet far less robust than the potential optimum. These and other findings provide new perspectives on the biological relevance of network structure and robustness.

  9. Why do hubs tend to be essential in protein networks?

    Directory of Open Access Journals (Sweden)

    Xionglei He

    2006-06-01

    Full Text Available The protein-protein interaction (PPI network has a small number of highly connected protein nodes (known as hubs and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centrality-lethality rule. This rule is widely believed to reflect the special importance of hubs in organizing the network, which in turn suggests the biological significance of network architectures, a key notion of systems biology. Despite the popularity of this explanation, the underlying cause of the centrality-lethality rule has never been critically examined. We here propose the concept of essential PPIs, which are PPIs that are indispensable for the survival or reproduction of an organism. Our network analysis suggests that the centrality-lethality rule is unrelated to the network architecture, but is explained by the simple fact that hubs have large numbers of PPIs, therefore high probabilities of engaging in essential PPIs. We estimate that approximately 3% of PPIs are essential in the yeast, accounting for approximately 43% of essential genes. As expected, essential PPIs are evolutionarily more conserved than nonessential PPIs. Considering the role of essential PPIs in determining gene essentiality, we find the yeast PPI network functionally more robust than random networks, yet far less robust than the potential optimum. These and other findings provide new perspectives on the biological relevance of network structure and robustness.

  10. New approaches to the marine transport hub competitive growth

    Directory of Open Access Journals (Sweden)

    M. V. Botnaryuk

    2010-12-01

    Full Text Available The issues of marine transport hub competitive growth in the context of new economic conditions are considered in the paper. Analyzing the present tools of the transport hub competitive growth, the author emphasizes their production-logistics orientation. However, when rendering services to cargo and ship owners, members of the MTH establish official (contractual and informal relationship and exchange information on a permanent basis. The research into the nature of such a relationship brought the author to the conclusion that generation and further development of the partnership is a basis for new ways of the transport hub competitive growth. Considering the MTH as an institution, the author suggests that a general marketing information system intended for improvement of the services rendered, which will undeniably enhance competitive advantage.

  11. An environmental transfer hub for multimodal atom probe tomography.

    Science.gov (United States)

    Perea, Daniel E; Gerstl, Stephan S A; Chin, Jackson; Hirschi, Blake; Evans, James E

    2017-01-01

    Environmental control during transfer between instruments is required for samples sensitive to air or thermal exposure to prevent morphological or chemical changes prior to analysis. Atom probe tomography is a rapidly expanding technique for three-dimensional structural and chemical analysis, but commercial instruments remain limited to loading specimens under ambient conditions. In this study, we describe a multifunctional environmental transfer hub allowing controlled cryogenic or room-temperature transfer of specimens under atmospheric or vacuum pressure conditions between an atom probe and other instruments or reaction chambers. The utility of the environmental transfer hub is demonstrated through the acquisition of previously unavailable mass spectral analysis of an intact organic molecule made possible via controlled cryogenic transfer into the atom probe using the hub. The ability to prepare and transfer specimens in precise environments promises a means to access new science across many disciplines from untainted samples and allow downstream time-resolved in situ atom probe studies.

  12. Microfluidic hubs, systems, and methods for interface fluidic modules

    Energy Technology Data Exchange (ETDEWEB)

    Bartsch, Michael S; Claudnic, Mark R; Kim, Hanyoup; Patel, Kamlesh D; Renzi, Ronald F; Van De Vreugde, James L

    2015-01-27

    Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.

  13. Robust Energy Hub Management Using Information Gap Decision Theory

    DEFF Research Database (Denmark)

    Javadi, Mohammad Sadegh; Anvari-Moghaddam, Amjad; Guerrero, Josep M.

    2017-01-01

    tools in order to deal with uncertainties and to provide reliable operating conditions. On a broader scale, an energy hub includes diverse energy sources for supplying both electrical load and heating/cooling demands with stochastic behaviors. Therefore, this paper utilizes the Information Decision Gap...... Theory (IGDT) to tackle this uncertainty as an efficient robust optimization tool with low complexity to ensure the optimal operation of the system according to the priorities of the decision maker entity. The proposed optimization framework is also implemented on a benchmark energy hub which includes...

  14. Variable volume combustor with center hub fuel staging

    Energy Technology Data Exchange (ETDEWEB)

    Ostebee, Heath Michael; McConnaughhay, Johnie Franklin; Stewart, Jason Thurman; Keener, Christopher Paul

    2016-08-23

    The present application and the resultant patent provide a combustor for use with a gas turbine engine. The combustor may include a number of micro-mixer fuel nozzles and a fuel injection system for providing a flow of fuel to the micro-mixer fuel nozzles. The fuel injection system may include a center hub for providing the flow of fuel therethrough. The center hub may include a first supply circuit for a first micro-mixer fuel nozzle and a second supply circuit for a second micro-mixer fuel nozzle.

  15. Bus coordination holding control for transit hubs under APTS

    Institute of Scientific and Technical Information of China (English)

    TENG Jing; ZHAO Ming

    2009-01-01

    To increase the passenger transferring efficiency, the bus coordination holding control for transit hubs,hich is as an important dynamic dispatching method for improving the service level of transit hubs, was studied in the framework of bus coordination dispatching mode. Firstly, the bus coordination holding control flow was studied based on Advanced Public Transportation Systems (APTS) environment. Then a control model was presented to optimize the bus vehicle holding time, and a genetic algorithm was designed as the solving method. In the end, an example was given to illustrate the effectiveness of the control strategy and the algorithm.

  16. Gradient-Based Optimization of Wind Farms with Different Turbine Heights: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Stanley, Andrew P. J.; Thomas, Jared; Ning, Andrew; Annoni, Jennifer; Dykes, Katherine; Fleming, Paul

    2017-05-08

    Turbine wakes reduce power production in a wind farm. Current wind farms are generally built with turbines that are all the same height, but if wind farms included turbines with different tower heights, the cost of energy (COE) may be reduced. We used gradient-based optimization to demonstrate a method to optimize wind farms with varied hub heights. Our study includes a modified version of the FLORIS wake model that accommodates three-dimensional wakes integrated with a tower structural model. Our purpose was to design a process to minimize the COE of a wind farm through layout optimization and varying turbine hub heights. Results indicate that when a farm is optimized for layout and height with two separate height groups, COE can be lowered by as much as 5%-9%, compared to a similar layout and height optimization where all the towers are the same. The COE has the best improvement in farms with high turbine density and a low wind shear exponent.

  17. Punching of lateral holes on automobile hub%汽车轮毂斜孔的冲制

    Institute of Scientific and Technical Information of China (English)

    黄晓慧; 吴向红

    2001-01-01

    介绍了汽车轮毂侧孔成形新方法的工作原理、模具结构及典型零件设计。该成形方法较传统的生产工艺有效率高、精度高等优点,并大大提高了零件动平衡能力,稳定了产品合格率。%The work principle, die structure and typical part design of the new forming method of lateral holes on automobile hub have been introduced. This new method has higher efficiency and precision than the traditional technology with stability of eligibility of product and has improved the dynamic balance ability and quality of automobile hub significantly.

  18. Sliding Mode Robustness Control Strategy for Shearer Height Adjusting System

    Directory of Open Access Journals (Sweden)

    Xiuping Su

    2013-09-01

    Full Text Available This paper firstly established mathematical model of height adjusting hydro cylinder of the shearer, as well as the state space equation of the shearer height adjusting system. Secondly we designed a shearer automatic height adjusting controller adopting the sliding mode robustness control strategy. The height adjusting controller includes the sliding mode surface switching function based on Ackermann formula, as well as sliding mode control function with the improved butterworth filter. Then simulation of the height adjustment controller shows that the sliding mode robustness control solves buffeting of typical controller, and achieves automatic control for the rolling drum of the shearer.

  19. On Wuthering Heights

    Institute of Scientific and Technical Information of China (English)

    马春玲

    2001-01-01

    本文剖析了小说主人公的悲惨命运及时代特征%Through the story of Wuthering Heights,the article analyzes the tragic fate of Heathcliff and the characteristic of the 19th century England.

  20. Narrators in Wuthering Heights

    Institute of Scientific and Technical Information of China (English)

    刘俊红

    2009-01-01

    Wuthering Heights is Emily Bront e's only novel. The narrative is non-linear, involving several flashbacks an dtwo primary narrators. Emily Bronte has adopted the device of introducing two narrators--Mr. Lockwood and Ellen "Nel-ly" Dean so as to achieve certain purpose.

  1. Modeling typical performance measures

    NARCIS (Netherlands)

    Weekers, Anke Martine

    2009-01-01

    In the educational, employment, and clinical context, attitude and personality inventories are used to measure typical performance traits. Statistical models are applied to obtain latent trait estimates. Often the same statistical models as the models used in maximum performance measurement are appl

  2. Portable Desktop Apps with GitHub Electron

    CERN Document Server

    CERN. Geneva

    2016-01-01

    Wouldn't it be nice if you could develop applications that work everywhere, regardless of Operating System or Platform? Even better, what if you could employ the same front-end technologies you use for your web/mobile apps? Meet GitHub Electron.

  3. The evolution of the MasAgro hubs

    NARCIS (Netherlands)

    Camacho-Villa, Tania Carolina; Almekinders, Conny; Hellin, Jon; Martinez-Cruz, Tania Eulalia; Rendon-Medel, Roberto; Guevara-Hernández, Francisco; Beuchelt, Tina D.; Govaerts, Bram

    2016-01-01

    Purpose: Little is known about effective ways to operationalize agricultural innovation processes. We use the MasAgro program in Mexico (which aims to increase maize and wheat productivity, profitability and sustainability), and the experiences of middle level ‘hub managers’, to understand how innov

  4. Native Avatars, Online Hubs, and Urban Indian Literature

    Science.gov (United States)

    Estrada, Gabriel S.

    2011-01-01

    Teaching American Indian literature with online resources can help diverse urban Indian and multicultural students connect with American Indian cultures, histories, and Nations. This online-enriched pedagogy adopts Susan Lobo's sense of the city as an "urban hub," or activist community center, an urban area linked to reservations in which Native…

  5. Fatigue Analysis of Casted Hubs in Wind Turbines

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Nielsen, Søren R.K.; Sørensen, Steffen

    2002-01-01

    The hub of a wind turbine rotor is excited by time-varying forces and moments from the blades caused by extemal dynamic loads such as wind loading and aeroelastic effects. The paper describes how reliability-based fatigue analysis can be made based on SN-curves and how reliability-based inspectio...

  6. Functional Connectivity Hubs and Networks in the Awake Marmoset Brain

    Directory of Open Access Journals (Sweden)

    Annabelle Marie Belcher

    2016-03-01

    Full Text Available In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to achieve a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly functionally connected nodes, or hubs, and we have recently proposed local functional connectivity density (lFCD mapping to identify highly-connected nodes in the human brain. Here we imaged awake nonhuman primates to test whether, like the human brain, the marmoset brain contains functional connectivity hubs. Ten adult common marmosets (Callithrix jacchus were acclimated to mild, comfortable restraint using individualized helmets. Following restraint training, resting BOLD data were acquired during eight consecutive 10 min scans for each subject. lFCD revealed prominent cortical and subcortical hubs of connectivity across the marmoset brain; specifically, in primary and secondary visual cortices (V1/V2, higher-order visual association areas (A19M/V6[DM], posterior parietal and posterior cingulate areas (PGM and A23b/A31, thalamus, dorsal and ventral striatal areas (caudate, putamen, lateral septal nucleus, and anterior cingulate cortex (A24a. lFCD hubs were highly connected to widespread areas of the brain, and further revealed significant network-network interactions. These data provide a baseline platform for future investigations in a nonhuman primate model of the brain’s network topology.

  7. The evolution of the MasAgro hubs

    NARCIS (Netherlands)

    Camacho-Villa, Tania Carolina; Almekinders, Conny; Hellin, Jon; Martinez-Cruz, Tania Eulalia; Rendon-Medel, Roberto; Guevara-Hernández, Francisco; Beuchelt, Tina D.; Govaerts, Bram

    2016-01-01

    Purpose: Little is known about effective ways to operationalize agricultural innovation processes. We use the MasAgro program in Mexico (which aims to increase maize and wheat productivity, profitability and sustainability), and the experiences of middle level ‘hub managers’, to understand how

  8. DAVINC3I: moving towards responsive hub network designs

    NARCIS (Netherlands)

    Ossevoort, R.; Keizer, de M.; Vorst, van der J.G.A.J.; Wenink, E.

    2013-01-01

    The Dutch floricultural sector is generally appreciated for its world leadership; the Netherlands is the flower trading hub for the European market. There are two trends affecting this position. First, virtualisation makes trade flows relatively footloose and flexible. Moreover, it enables the use o

  9. Discovering Authorities and Hubs in Different Topological Web Graph Structures.

    Science.gov (United States)

    Meghabghab, George

    2002-01-01

    Discussion of citation analysis on the Web considers Web hyperlinks as a source to analyze citations. Topics include basic graph theory applied to Web pages, including matrices, linear algebra, and Web topology; and hubs and authorities, including a search technique called HITS (Hyperlink Induced Topic Search). (Author/LRW)

  10. DAVINC3I: moving towards responsive hub network designs

    NARCIS (Netherlands)

    Ossevoort, R.; Keizer, de M.; Vorst, van der J.G.A.J.; Wenink, E.

    2013-01-01

    The Dutch floricultural sector is generally appreciated for its world leadership; the Netherlands is the flower trading hub for the European market. There are two trends affecting this position. First, virtualisation makes trade flows relatively footloose and flexible. Moreover, it enables the use o

  11. Interaction of railway and marine transport (Murmansk Transport Hub

    Directory of Open Access Journals (Sweden)

    Sokolov A.A.

    2015-03-01

    Full Text Available The classification of problems of interaction between water (marine and railway transport on the example of the Murmansk Transport Hub has been presented; some prospects for the development of technology for interaction with the logistics of transportation of general cargo in the Murmansk Commercial Seaport, Murmansk Marine Fishing Port, and oil terminals of the Kola Bay have been shown

  12. The Urban Food Hubs Solution: Building Capacity in Urban Communities

    Science.gov (United States)

    O'Hara, Sabine

    2017-01-01

    Access to affordable fresh food is an ongoing challenge for underserved urban neighborhoods across the United States. Several are designated food deserts with no access to a full-service grocery store within a one-mile radius. The Urban Food Hubs of the College of Agriculture, Urban Sustainability, and Environmental Sciences (CAUSES) of the…

  13. Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks

    Science.gov (United States)

    Torcini, Alessandro; Luccioli, Stefano; Bonifazi, Paolo; Ben-Jacob, Eshel; Barzilai, Ari

    2015-03-01

    It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in developing neuronal circuits, typically composed of only excitatory cells, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally regulated constraints on single neuron excitability and connectivity leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity. This work is part of the activity of the Joint Italian-Israeli Laboratory on Integrative Network Neuroscience supported by the Italian Ministry of Foreign Affairs.

  14. Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.

    Science.gov (United States)

    Sugitani, Norie; Chazin, Walter J

    2015-03-01

    DNA replication, damage response and repair require the coordinated action of multi-domain proteins operating within dynamic multi-protein machines that act upon the DNA substrate. These modular proteins contain flexible linkers of various lengths, which enable changes in the spatial distribution of the globular domains (architecture) that harbor their essential biochemical functions. This mobile architecture is uniquely suited to follow the evolving substrate landscape present over the course of the specific process performed by the multi-protein machinery. A fundamental advance in understanding of protein machinery is the realization of the pervasive role of dynamics. Not only is the machine undergoing dynamic transformations, but the proteins themselves are flexible and constantly adapting to the progression through the steps of the overall process. Within this dynamic context the activity of the constituent proteins must be coordinated, a role typically played by hub proteins. A number of important characteristics of modular proteins and concepts about the operation of dynamic machinery have been discerned. These provide the underlying basis for the action of the machinery that reads DNA, and responds to and repairs DNA damage. Here, we introduce a number of key characteristics and concepts, including the modularity of the proteins, linkage of weak binding sites, direct competition between sites, and allostery, using the well recognized hub protein replication protein A (RPA).

  15. Multiple Hub Network Choice in the Liberalized European Market

    Science.gov (United States)

    Berechman, Joseph; deWit, Jaap

    1997-01-01

    A key question that so far has received relatively little attention in the germane literature is that of the changes at various airports as a result of the EU liberalization policies. That is, presently, most major European airports still benefit from the so-called home-carrier phenomenon where the country's publicly or semi-publicly owned carrier uses the country's main airport as its gateway hub and, consequently, the home-carrier is also the principal user of this airport (in terms of proportion of total aircraft movements, number of passengers transported, connections, slots ownership, etc.). The country's main airport has substantially benefited from these monopoly conditions of airline captivity, strongly determined by the bilateral system of international air transport regulation. Therefore, European major airports were used to operate in essentially different markets, compared to the increasingly competitive markets of their home based carriers. This partly explains relative stability of transport volumes and financial results of European major airports compared to the relatively volatile financial results of most European national airlines. However, the liberalization of European aviation is likely to change this situation. Market access is open now to all community carriers, i.e. carriers with majority ownership and effective control in the hands of EU citizens. Ticket prices are free, governments can only intervene in case of dumping or excessive pricing. A community airline can choose its seat in any of the 15 member states. Licensing procedures are harmonized between member states. In the last few months community carriers have had unrestricted route access within the EU. Most probably this development will be extended to countries inside and outside Europe. Last year the European Commission got the mandate to start negotiations with 10 other European countries. In the meantime the EC has also started negotiations with the USA on so-called soft rights

  16. Typicals/Típicos

    Directory of Open Access Journals (Sweden)

    Silvia Vélez

    2004-01-01

    Full Text Available Typicals is a series of 12 colour photographs digitally created from photojournalistic images from Colombia combined with "typical" craft textiles and text from guest writers. Typicals was first exhibited as photographs 50cm x 75cm in size, each with their own magnifying glass, at the Contemporary Art Space at Gorman House in Canberra, Australia, in 2000. It was then exhibited in "Feedback: Art Social Consciousness and Resistance" at Monash University Museum of Art in Melbourne, Australia, from March to May 2003. From May to June 2003 it was exhibited at the Museo de Arte de la Universidad Nacional de Colombia Santa Fé Bogotá, Colombia. In its current manifestation the artwork has been adapted from the catalogue of the museum exhibitions. It is broken up into eight pieces corresponding to the contributions of the writers. The introduction by Sylvia Vélez is the PDF file accessible via a link below this abstract. The other seven PDF files are accessible via the 'Research Support Tool' section to the right of your screen. Please click on 'Supp. Files'. Please note that these files are around 4 megabytes each, so it may be difficult to access them from a dial-up connection.

  17. Fear of heights and mild visual height intolerance independent of alcohol consumption.

    Science.gov (United States)

    Huppert, Doreen; Grill, Eva; Kapfhammer, Hans-Peter; Brandt, Thomas

    2013-09-01

    Background Visual height intolerance occurs when a visual stimulus causes apprehension of losing balance and falling from some height. Affecting one-third of the population, it has a broad spectrum of symptoms, ranging from minor distress to fear of heights, which is defined as a specific phobia. Specific phobias are associated with higher alcohol consumption. This has not been specifically shown for susceptibility to the more general visual height intolerance. Methods Representative case-control study nested within a population-based cross-sectional telephone survey to assess epidemiologically 1253 individuals ≥14 years, using a questionnaire on sociodemographic data, typical symptoms, precipitating visual stimuli, and alcohol drinking patterns (overall frequency of alcohol consumption, the daily quantities, and the motives). Results Individuals susceptible or nonsusceptible to visual height intolerance showed no significant differences in drinking patterns. The daily average alcohol consumption was slightly higher in persons susceptible to visual height intolerance (4.1 g/day vs. 3.7 g/day). Of those consuming alcohol, cases and controls reported on average consuming 2.3 glasses per day. The prevalence of visual height intolerance was insignificantly higher in the small minority of those drinking 2-3 times per week versus teetotalers. Conclusions Our study does not provide evidence that visual height intolerance - contrary to various specific phobias - is significantly associated with individual alcohol consumption patterns.

  18. Childhood height, adult height, and the risk of prostate cancer

    DEFF Research Database (Denmark)

    Bjerregaard, Lise Geisler; Aarestrup, Julie; Gamborg, Michael;

    2016-01-01

    PURPOSE: We previously showed that childhood height is positively associated with prostate cancer risk. It is, however, unknown whether childhood height exerts its effects independently of or through adult height. We investigated whether and to what extent childhood height has a direct effect...... on the risk of prostate cancer apart from adult height. METHODS: We included 5,871 men with height measured at ages 7 and 13 years in the Copenhagen School Health Records Register who also had adult (50-65 years) height measured in the Danish Diet, Cancer and Health study. Prostate cancer status was obtained...... through linkage to the Danish Cancer Registry. Direct and total effects of childhood height on prostate cancer risk were estimated from Cox regressions. RESULTS: From 1996 to 2012, 429 prostate cancers occurred. Child and adult heights were positively and significantly associated with prostate cancer risk...

  19. Optimization of Truss Height

    Directory of Open Access Journals (Sweden)

    Tomas Ulitinas

    2011-04-01

    Full Text Available The article analyzes the task in truss height and in the optimization of the cross-sections of their elements. Element cross-sections are designed of steel profiles considering requirements for strength, stability and rigidity. A mathematical model is formulated as a nonlinear mathematical programming problem. It is solved as an iterative process, using mathematical software package “MATLAB” routine “fmincon”. The ratio of buckling is corrected in the each iteration. Optimization results are compared with those obtained applying software package “Robot Millennium”.Article in Lithuanian

  20. Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks.

    Directory of Open Access Journals (Sweden)

    Sumeet Agarwal

    2010-06-01

    Full Text Available The idea of "date" and "party" hubs has been influential in the study of protein-protein interaction networks. Date hubs display low co-expression with their partners, whilst party hubs have high co-expression. It was proposed that party hubs are local coordinators whereas date hubs are global connectors. Here, we show that the reported importance of date hubs to network connectivity can in fact be attributed to a tiny subset of them. Crucially, these few, extremely central, hubs do not display particularly low expression correlation, undermining the idea of a link between this quantity and hub function. The date/party distinction was originally motivated by an approximately bimodal distribution of hub co-expression; we show that this feature is not always robust to methodological changes. Additionally, topological properties of hubs do not in general correlate with co-expression. However, we find significant correlations between interaction centrality and the functional similarity of the interacting proteins. We suggest that thinking in terms of a date/party dichotomy for hubs in protein interaction networks is not meaningful, and it might be more useful to conceive of roles for protein-protein interactions rather than for individual proteins.

  1. Location of an intermediate hub for port activities

    Science.gov (United States)

    Burciu, Ş.; Ştefănică, C.; Roşca, E.; Dragu, V.; Ruscă, F.

    2015-11-01

    An intermediate hub might increase the accessibility level of ports but also hinterland and so it can be considered more than a facility with a transhipment role. These hubs might lead to the development of other transport services and enhance their role in gathering and covering economic centres within hinterlands and also getting the part of logistic facility for the ports, with effects on port utilization and its connectivity to global economy. A new location for a hub terminal leads to reduced transport distances within hinterland, with decreased transport costs and external effects, so with gains in people's life quality. Because the production and distribution systems are relatively fixed on short and medium term and the location decisions are strategic and on long term, the logistic chains activities location models have to consider the uncertainties regarding the possible future situations. In most models, production costs are considered equal, the location problem reducing itself to a problem that aims to minimize the total transport costs, meaning the transport problem. The main objective of the paper is to locate a hub terminal that links the producers of cereals that are going to be exported by naval transportation with the Romanian fluvial-maritime ports (Galaţi, Brăila). GIS environment can be used to integrate and analyse a great amount of data and has the ability of using functions as location - allocation models necessary both to private and public sector, being able to determine the optimal location for services like factories, warehouses, logistic platforms and other public services.

  2. An environmental transfer hub for multimodal atom probe tomography

    Energy Technology Data Exchange (ETDEWEB)

    Perea, Daniel E.; Gerstl, Stephan S. A.; Chin, Jackson; Hirschi, Blake; Evans, James. E.

    2017-05-02

    Environmental control during transfer between instruments is required for specimens sensitive to air or thermal exposure to prevent morphological or chemical changes. Atom Probe Tomography is an expanding technique but commercial instruments remain limited to loading under ambient conditions. Here we describe a multifunctional environmental transfer hub allowing controlled cryogenic, atmospheric and vacuum transfer between an Atom Probe and other instruments containing separate chambers to allow downstream time-resolved in-situ studies.

  3. The home hemodialysis hub: physical infrastructure and integrated governance structure.

    Science.gov (United States)

    Marshall, Mark R; Young, Bessie A; Fox, Sally J; Cleland, Calli J; Walker, Robert J; Masakane, Ikuto; Herold, Aaron M

    2015-04-01

    An effective home hemodialysis program critically depends on adequate hub facilities and support functions and on transparent and accountable organizational processes. The likelihood of optimal service delivery and patient care will be enhanced by fit-for-purpose facilities and implementation of a well-considered governance structure. In this article, we describe the required accommodation and infrastructure for a home hemodialysis program and a generic organizational structure that will support both patient-facing clinical activities and business processes.

  4. Robust design of a polygonal shaft-hub coupling

    Directory of Open Access Journals (Sweden)

    R. Citarella

    2015-10-01

    Full Text Available In this work, the Taguchi method is applied for the optimal choice of design parameter values for a polygonal shaft-hub coupling. The objective is to maximize a performance function, minimizing, at the same time, its sensitivity to noises factors (robust design. The Design of Experiments (DoE is adopted to set up a plan of numerical experiments, whose different configurations are simulated using the Boundary Element Method (BEM

  5. Performance evaluation of interconnected logistics networks confronted to hub disruptions

    OpenAIRE

    2016-01-01

    International audience; This paper investigates performance of interconnected logistics networks confronted to disruptions at hub level. With traditional supply chain network design, companies define and optimize their own logistics networks, resulting in current logistics systems being a set of independent heterogeneous logistics networks. The concept of PI aims to integrate independent logistics networks into a global, open, interconnected system. Prior research has shown that the new organ...

  6. Looking east, looking west: Penang as a knowledge hub

    OpenAIRE

    Gerke, Solvay; Evers, Hans-Dieter

    2012-01-01

    Penang has always been a focal point, absorbing knowledge (and popular culture) from civilizations to the East and West. In modern Penang the pattern of cultural contacts has changed over time. Research institutes and universities in Penang cooperate with foreign partners to produce research papers and reports. Based on an analysis of joint research output, the changing international position of Penang as an emerging research hub will be analysed. The paper will show that international cooper...

  7. A Hub Matrix Theory and Applications to Wireless Communications

    Directory of Open Access Journals (Sweden)

    H. T. Kung

    2007-01-01

    Full Text Available This paper considers communications and network systems whose properties are characterized by the gaps of the leading eigenvalues of AHA for a matrix A. It is shown that a sufficient and necessary condition for a large eigen-gap is that A is a “hub” matrix in the sense that it has dominant columns. Some applications of this hub theory in multiple-input and multiple-output (MIMO wireless systems are presented.

  8. Idea Exchange Music Hub Hits the Right Note in Community

    Directory of Open Access Journals (Sweden)

    Greg Bester

    2014-06-01

    Full Text Available The Cambridge Libraries and Galleries has made many changes over the last two years, rebranding as Idea Exchange and adding 3D printers, creative spaces and many on-site events. This article focuses on one of the organization’s newest innovations, the addition of a Music Hub, and the challenges of creating a space where members can learn and collaborate musically without disturbing those around them.

  9. Research dedusting efficiency of the inertial hub with adjustable parameters

    Directory of Open Access Journals (Sweden)

    Sharapov Rashid

    2016-01-01

    Full Text Available Production of construction materials every year production increases, thus increasing emissions pollutants into the atmosphere subjected to cleaning. At the enterprises of building materials production equipment becoming outdated both morally and physically exhausted their useful life. Technological design standards in the operation of purification equipment has undergone a number of changes. There are a large number of works devoted to the theory of cyclone separation. They examined calculation method and to determine the minimum size of particles is separated completely from the air stream in a cyclone. In theory, the high efficiency cyclones are relatively small separation of particles from the air stream. The experiments show that certain fractions of full capture occurs from the cyclones and out relatively large particles. Designed dust device hubs. They capture dust particles with low specific density and smaller than 5–10 microns. Rational use of hubs is achieved in the aspiration systems high performance. They are placed in front of or between the filter and the cyclone filter. Hub much reduces the amount of dust-laden air directed onto a thin cleaning. This reduces energy consumption for manufacturing as a whole, as well as, due to a possible decrease in performance fine filters, reducing their initial cost, metal consumption, maintenance costs and reduce the area occupied by them.

  10. Matrix logistics indicators assessment of distributed transport hub

    Directory of Open Access Journals (Sweden)

    Igor Arefyev

    2014-06-01

    Full Text Available Background: The paper is devoted to the distributed transport hub substantiation and assessment. The paper  was an example of the technique and form an array of logistical factors as variables that determine this condition. Experience in organizing multimodal transport showed that the "bottleneck" of transport logistics are items of cargo handling ports, terminals, freight stations and warehouses. At the core of the solution of these problems is the problem of estimating the variables determine the Multi-purpose Hubs. The aim is to develop a method of forming the system of logistical multiplying factors determine the role of each of the types in the technologiacal process of distributed Multi-purpose Hubs. Methods: The assessment model for the formation of Distributed Transport Units  can be based on formal methods to predict the behavior of complex systems engineering complexes. Then one of the approaches to the solution of the problem may be the matrix method of technological factors. Results and conclusions: The proposed methodology of the selection and validation of logistic coefficients has the practical importance in the models development for assessing the condition and behavior of Distributed Transport.

  11. The coffee genome hub: a resource for coffee genomes.

    Science.gov (United States)

    Dereeper, Alexis; Bocs, Stéphanie; Rouard, Mathieu; Guignon, Valentin; Ravel, Sébastien; Tranchant-Dubreuil, Christine; Poncet, Valérie; Garsmeur, Olivier; Lashermes, Philippe; Droc, Gaëtan

    2015-01-01

    The whole genome sequence of Coffea canephora, the perennial diploid species known as Robusta, has been recently released. In the context of the C. canephora genome sequencing project and to support post-genomics efforts, we developed the Coffee Genome Hub (http://coffee-genome.org/), an integrative genome information system that allows centralized access to genomics and genetics data and analysis tools to facilitate translational and applied research in coffee. We provide the complete genome sequence of C. canephora along with gene structure, gene product information, metabolism, gene families, transcriptomics, syntenic blocks, genetic markers and genetic maps. The hub relies on generic software (e.g. GMOD tools) for easy querying, visualizing and downloading research data. It includes a Genome Browser enhanced by a Community Annotation System, enabling the improvement of automatic gene annotation through an annotation editor. In addition, the hub aims at developing interoperability among other existing South Green tools managing coffee data (phylogenomics resources, SNPs) and/or supporting data analyses with the Galaxy workflow manager. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  12. Spider orientation and hub position in orb webs

    Science.gov (United States)

    Zschokke, Samuel; Nakata, Kensuke

    2010-01-01

    Orb-web building spiders (Araneae: Araneoidea, Uloboridae) can be considered as territorial central place foragers. In territorial central place foragers, the optimal foraging arena is circular, with the forager sitting in its centre. In orb webs, the spider’s orientation (head up or head down) whilst waiting for prey on the hub of its web and the downwards-upwards asymmetry of its running speeds are the probable causes for the observed deviation of the hub from the web’s centre. Here, we present an analytical model and a more refined simulation model to analyse the relationships amongst the spider’s running speeds, its orientation whilst waiting for prey and the vertical asymmetry of orb webs. The results of our models suggest that (a) waiting for prey head down is generally favourable because it allows the spider to reach the prey in its web on average quicker than spiders waiting head up, (b) the downwards-upwards running speed asymmetry, together with the head-down orientation of most spiders, are likely causes for the observed vertical asymmetry of orb webs, (c) waiting head up can be advantageous for spiders whose downwards-upwards running speed asymmetry is small and who experience high prey tumbling rates and (d) spiders waiting head up should place their hub lower than similar spiders waiting head down.

  13. A Typical Synergy

    Science.gov (United States)

    van Noort, Thomas; Achten, Peter; Plasmeijer, Rinus

    We present a typical synergy between dynamic types (dynamics) and generalised algebraic datatypes (GADTs). The former provides a clean approach to integrating dynamic typing in a statically typed language. It allows values to be wrapped together with their type in a uniform package, deferring type unification until run time using a pattern match annotated with the desired type. The latter allows for the explicit specification of constructor types, as to enforce their structural validity. In contrast to ADTs, GADTs are heterogeneous structures since each constructor type is implicitly universally quantified. Unfortunately, pattern matching only enforces structural validity and does not provide instantiation information on polymorphic types. Consequently, functions that manipulate such values, such as a type-safe update function, are cumbersome due to boilerplate type representation administration. In this paper we focus on improving such functions by providing a new GADT annotation via a natural synergy with dynamics. We formally define the semantics of the annotation and touch on novel other applications of this technique such as type dispatching and enforcing type equality invariants on GADT values.

  14. Virtual Hubs for facilitating access to Open Data

    Science.gov (United States)

    Mazzetti, Paolo; Latre, Miguel Á.; Ernst, Julia; Brumana, Raffaella; Brauman, Stefan; Nativi, Stefano

    2015-04-01

    In October 2014 the ENERGIC-OD (European NEtwork for Redistributing Geospatial Information to user Communities - Open Data) project, funded by the European Union under the Competitiveness and Innovation framework Programme (CIP), has started. In response to the EU call, the general objective of the project is to "facilitate the use of open (freely available) geographic data from different sources for the creation of innovative applications and services through the creation of Virtual Hubs". In ENERGIC-OD, Virtual Hubs are conceived as information systems supporting the full life cycle of Open Data: publishing, discovery and access. They facilitate the use of Open Data by lowering and possibly removing the main barriers which hampers geo-information (GI) usage by end-users and application developers. Data and data services heterogeneity is recognized as one of the major barriers to Open Data (re-)use. It imposes end-users and developers to spend a lot of effort in accessing different infrastructures and harmonizing datasets. Such heterogeneity cannot be completely removed through the adoption of standard specifications for service interfaces, metadata and data models, since different infrastructures adopt different standards to answer to specific challenges and to address specific use-cases. Thus, beyond a certain extent, heterogeneity is irreducible especially in interdisciplinary contexts. ENERGIC-OD Virtual Hubs address heterogeneity adopting a mediation and brokering approach: specific components (brokers) are dedicated to harmonize service interfaces, metadata and data models, enabling seamless discovery and access to heterogeneous infrastructures and datasets. As an innovation project, ENERGIC-OD will integrate several existing technologies to implement Virtual Hubs as single points of access to geospatial datasets provided by new or existing platforms and infrastructures, including INSPIRE-compliant systems and Copernicus services. ENERGIC OD will deploy a

  15. Contextual Hub Analysis Tool (CHAT: A Cytoscape app for identifying contextually relevant hubs in biological networks [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Tanja Muetze

    2016-08-01

    Full Text Available Highly connected nodes (hubs in biological networks are topologically important to the structure of the network and have also been shown to be preferentially associated with a range of phenotypes of interest. The relative importance of a hub node, however, can change depending on the biological context. Here, we report a Cytoscape app, the Contextual Hub Analysis Tool (CHAT, which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene expression or mass spectrometry data, and identify hub nodes that are more highly connected to contextual nodes (e.g. genes or proteins that are differentially expressed than expected by chance. In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection. CHAT was used to identify and compare contextual and degree-based hubs in this network. The top 20 degree-based hubs were enriched in pathways related to the cell cycle and cancer, which is likely due to the fact that proteins involved in these processes tend to be highly connected in general. In comparison, the top 20 contextual hubs were enriched in pathways commonly observed in a viral infection including pathways related to the immune response to viral infection. This analysis shows that such contextual hubs are considerably more biologically relevant than degree-based hubs and that analyses which rely on the identification of hubs solely based on their connectivity may be biased towards nodes that are highly connected in general rather than in the specific context of interest.   Availability: CHAT is available for Cytoscape 3.0+ and can be installed via the Cytoscape App Store (http://apps.cytoscape.org/apps/chat.

  16. An Endosymbiotic Evolutionary Algorithm for the Hub Location-Routing Problem

    Directory of Open Access Journals (Sweden)

    Ji Ung Sun

    2015-01-01

    Full Text Available We consider a capacitated hub location-routing problem (HLRP which combines the hub location problem and multihub vehicle routing decisions. The HLRP not only determines the locations of the capacitated p-hubs within a set of potential hubs but also deals with the routes of the vehicles to meet the demands of customers. This problem is formulated as a 0-1 mixed integer programming model with the objective of the minimum total cost including routing cost, fixed hub cost, and fixed vehicle cost. As the HLRP has impractically demanding for the large sized problems, we develop a solution method based on the endosymbiotic evolutionary algorithm (EEA which solves hub location and vehicle routing problem simultaneously. The performance of the proposed algorithm is examined through a comparative study. The experimental results show that the proposed EEA can be a viable solution method for the supply chain network planning.

  17. Wake center position tracking using downstream wind turbine hub loads

    Science.gov (United States)

    Cacciola, S.; Bertelè, M.; Schreiber, J.; Bottasso, C. L.

    2016-09-01

    Having an improved awareness of the flow within a wind farm is useful for power harvesting maximization, load minimization and design of wind farm layout. Local flow information at each wind turbine location can be obtained by using the response of the wind turbines, which are consequently used as distributed sensors. This paper proposes the use of hub loads to track the position of wakes within a wind farm. Simulation experiments conducted within a high-fidelity aeroservoelastic environment demonstrate the performance of the new method.

  18. Collective versus hub activation of epidemic phases on networks

    CERN Document Server

    Ferreira, Silvio C; Pastor-Satorras, Romualdo

    2015-01-01

    We consider a general criterion to discern the nature of the threshold in epidemic models on scale-free (SF) networks. Comparing the epidemic lifespan of the nodes with largest degrees with the infection time between them, we propose a general dual scenario, in which the epidemic transition is either ruled by a hub activation process, leading to a null threshold in the thermodynamic limit, or given by a collective activation process, corresponding to a standard phase transition with a finite threshold. We validate the proposed criterion applying it different to epidemic models, with waning immunity or heterogeneous infection rates.

  19. The hubs of the human connectome are generally implicated in the anatomy of brain disorders.

    Science.gov (United States)

    Crossley, Nicolas A; Mechelli, Andrea; Scott, Jessica; Carletti, Francesco; Fox, Peter T; McGuire, Philip; Bullmore, Edward T

    2014-08-01

    Brain networks or 'connectomes' include a minority of highly connected hub nodes that are functionally valuable, because their topological centrality supports integrative processing and adaptive behaviours. Recent studies also suggest that hubs have higher metabolic demands and longer-distance connections than other brain regions, and therefore could be considered biologically costly. Assuming that hubs thus normally combine both high topological value and high biological cost, we predicted that pathological brain lesions would be concentrated in hub regions. To test this general hypothesis, we first identified the hubs of brain anatomical networks estimated from diffusion tensor imaging data on healthy volunteers (n = 56), and showed that computational attacks targeted on hubs disproportionally degraded the efficiency of brain networks compared to random attacks. We then prepared grey matter lesion maps, based on meta-analyses of published magnetic resonance imaging data on more than 20 000 subjects and 26 different brain disorders. Magnetic resonance imaging lesions that were common across all brain disorders were more likely to be located in hubs of the normal brain connectome (P brain disorders had lesions that were significantly more likely to be located in hubs (P human brain networks are more likely to be anatomically abnormal than non-hubs in many (if not all) brain disorders. © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain.

  20. Design of targeted libraries against the human Chk1 kinase using PGVL Hub.

    Science.gov (United States)

    Peng, Zhengwei; Hu, Qiyue

    2011-01-01

    PGVL Hub is a Pfizer internal desktop tool for chemical library and singleton design. In this chapter, we give a short introduction to PGVL Hub, the core workflow it supports, and the rich design capabilities it provides. By re-creating two legacy targeted libraries against the human checkpoint kinase 1 (Chk1) as a showcase, we illustrate how PGVL Hub could be used to help library designers carry out the steps in library design and realize design objectives such as SAR expansion and improvement in both kinase selectivity and compound aqueous solubility. Finally we share several tips about library design and usage of PGVL Hub.

  1. PASSENGER SERVICE QUALITY PARAMETERS ASSESSMENT AT TRANSPORT INTERCHANGE HUBS

    Directory of Open Access Journals (Sweden)

    Kozlov Pavel Igorevich

    2017-05-01

    Full Text Available The article discusses a quality assessment method for transport decisions made in transport interchange hubs. Analysis of domestic regulatory documentation and international experience on this subject is performed. It is stated that the domestic regulatory documentation lacks such method of assessment. Special attention is paid to study of pedestrian flows in interchange complexes of intermodal transport interchange hubs. The aim of the study is development of the Level of Service comprehensive assessment criterion by analogy with the international practice. The authors propose to use the queueing theory with elements of the theory of graphs, techniques and regularities that underlie the Level of Service (service factor applied in planning and location of TIH in the USA as well as data from field surveys carried out by the pedestrian flows video detection method. During the field surveys it is planned to perform analysis of external and internal factors influencing the formation and composition of a pedestrian flow, to determine quantitative values of the main parameters of pedestrian flow (density, speed, intensity and regularities of their variation depending on the design features of pedestrian traffic environment. Determination of passenger service quality factors in TIH will help to develop an integral criterion based on the Level of Service, taking into account the specifics of TIH functioning in Russia as well as a methodology that allows a reasonable choice of combinations of structural elements and planning parameters of pedestrian traffic objects which will let to reduce construction costs and operating costs for location of interchange complexes.

  2. Disinfection of Needleless Connector Hubs: Clinical Evidence Systematic Review

    Science.gov (United States)

    Moureau, Nancy L.

    2015-01-01

    Background. Needleless connectors (NC) are used on virtually all intravascular devices, providing an easy access point for infusion connection. Colonization of NC is considered the cause of 50% of postinsertion catheter-related infections. Breaks in aseptic technique, from failure to disinfect, result in contamination and subsequent biofilm formation within NC and catheters increasing the potential for infection of central and peripheral catheters. Methods. This systematic review evaluated 140 studies and 34 abstracts on NC disinfection practices, the impact of hub contamination on infection, and measures of education and compliance. Results. The greatest risk for contamination of the catheter after insertion is the NC with 33–45% contaminated, and compliance with disinfection as low as 10%. The optimal technique or disinfection time has not been identified, although scrubbing with 70% alcohol for 5–60 seconds is recommended. Studies have reported statistically significant results in infection reduction when passive alcohol disinfection caps are used (48–86% reduction). Clinical Implications. It is critical for healthcare facilities and clinicians to take responsibility for compliance with basic principles of asepsis compliance, to involve frontline staff in strategies, to facilitate education that promotes understanding of the consequences of failure, and to comply with the standard of care for hub disinfection. PMID:26075093

  3. Disinfection of Needleless Connector Hubs: Clinical Evidence Systematic Review

    Directory of Open Access Journals (Sweden)

    Nancy L. Moureau

    2015-01-01

    Full Text Available Background. Needleless connectors (NC are used on virtually all intravascular devices, providing an easy access point for infusion connection. Colonization of NC is considered the cause of 50% of postinsertion catheter-related infections. Breaks in aseptic technique, from failure to disinfect, result in contamination and subsequent biofilm formation within NC and catheters increasing the potential for infection of central and peripheral catheters. Methods. This systematic review evaluated 140 studies and 34 abstracts on NC disinfection practices, the impact of hub contamination on infection, and measures of education and compliance. Results. The greatest risk for contamination of the catheter after insertion is the NC with 33–45% contaminated, and compliance with disinfection as low as 10%. The optimal technique or disinfection time has not been identified, although scrubbing with 70% alcohol for 5–60 seconds is recommended. Studies have reported statistically significant results in infection reduction when passive alcohol disinfection caps are used (48–86% reduction. Clinical Implications. It is critical for healthcare facilities and clinicians to take responsibility for compliance with basic principles of asepsis compliance, to involve frontline staff in strategies, to facilitate education that promotes understanding of the consequences of failure, and to comply with the standard of care for hub disinfection.

  4. Design and Development of an Integrated Workstation Automation Hub

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Andrew; Ghatikar, Girish; Sartor, Dale; Lanzisera, Steven

    2015-03-30

    Miscellaneous Electronic Loads (MELs) account for one third of all electricity consumption in U.S. commercial buildings, and are drivers for a significant energy use in India. Many of the MEL-specific plug-load devices are concentrated at workstations in offices. The use of intelligence, and integrated controls and communications at the workstation for an Office Automation Hub – offers the opportunity to improve both energy efficiency and occupant comfort, along with services for Smart Grid operations. Software and hardware solutions are available from a wide array of vendors for the different components, but an integrated system with interoperable communications is yet to be developed and deployed. In this study, we propose system- and component-level specifications for the Office Automation Hub, their functions, and a prioritized list for the design of a proof-of-concept system. Leveraging the strength of both the U.S. and India technology sectors, this specification serves as a guide for researchers and industry in both countries to support the development, testing, and evaluation of a prototype product. Further evaluation of such integrated technologies for performance and cost is necessary to identify the potential to reduce energy consumptions in MELs and to improve occupant comfort.

  5. Knowledge Hub y los recursos educativos abiertos en Contaduría

    OpenAIRE

    Farías Martínez, Gabriela María

    2010-01-01

    Desafíos de la educación superior en México; Formación académica y profesional en contaduría; Knowledge Hub como medio para compartir y construir conocimiento; Iniciativa Knowledge Hub IES Contaduría

  6. 14 CFR 158.30 - PFC Authorization at Non-Hub Airports.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false PFC Authorization at Non-Hub Airports. 158... (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Application and Approval § 158.30 PFC Authorization at Non-Hub Airports. (a) General. This section specifies the procedures a public agency controlling...

  7. The Complexities and Challenges of Regional Education Hubs: Focus on Malaysia

    Science.gov (United States)

    Knight, Jane; Morshidi, Sirat

    2011-01-01

    The race to establish regional education hubs is a recent development in cross-border higher education. This article briefly examines the rationales and strategies used by three countries in the Middle East and three in South East Asia which are working towards positioning themselves as regional education hubs. The different approaches and…

  8. Knowledge Hub y los recursos educativos abiertos en Contaduría

    OpenAIRE

    Farías Martínez, Gabriela María

    2013-01-01

    Desafíos de la educación superior en México; Formación académica y profesional en contaduría; Knowledge Hub como medio para compartir y construir conocimiento; Iniciativa Knowledge Hub IES Contaduría

  9. A multi-objective imperialist competitive algorithm for a capacitated hub covering location problem

    Directory of Open Access Journals (Sweden)

    M. Mohammadi

    2011-01-01

    Full Text Available The hub location problem appears in a variety of applications, including airline systems, cargo delivery systems and telecommunication network design. Hub location problems deal with finding the location of hub facilities and the allocation of demand nodes to these located hub facilities. In this paper, a new model for the capacitated single allocation hub covering location problem is presented. Instead of using capacity constraints to limit the amount of flow received by the hubs, the second objective function is introduced to minimize service times in the hubs. The service time in the hubs includes the waiting time of received flows in a queue and the time to get services. Due to the NP-hardness of the problem, a new weight-based multi-objective imperialist competitive algorithm (MOICA is designed to find near-optimal solutions. To validate the performance of the proposed algorithm, the solutions obtained by the MOICA are compared by the exact solutions of the mathematical programming model.

  10. Domestic Output of Aluminium Alloy Hub Surpassing 70 million in 2007

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>According to a report from the hub branch of China Association of Automobile Manufactur- ers,China has produced a total of more than 70 million aluminium alloy hubs in 2007,a year- on-year growth over 25%,while consuming over 700,000 tons of primary aluminium the whole year.

  11. Optimal Scheduling of a Multi-Carrier Energy Hub Supplemented By Battery Energy Storage Systems

    DEFF Research Database (Denmark)

    Javadi, Mohammad Sadegh; Anvari-Moghaddam, Amjad; Guerrero, Josep M.

    2017-01-01

    This paper introduces a management model for optimal scheduling of a multi-carrier energy hub. In the proposed hub, three types of assets are considered: dispersed generating systems (DGs) such as micro-combined heat and power (mCHP) units, storage devices such as battery-based electrical storage...

  12. Network performance, hub connectivity potential, and competitive position of primary airports in Asia/Pacific region

    NARCIS (Netherlands)

    Matsumoto, H.; Veldhuis, J.; de Wit, J.; Burghouwt, G.

    2008-01-01

    Recently, hub-and-spoke network configurations are more and more developed in the Asia/Pacific region. In this paper, it is argued that the measurement of network performance in hub-and-spoke systems should take into account the quantity and quality of both direct and indirect connections. The NetSc

  13. The Complexities and Challenges of Regional Education Hubs: Focus on Malaysia

    Science.gov (United States)

    Knight, Jane; Morshidi, Sirat

    2011-01-01

    The race to establish regional education hubs is a recent development in cross-border higher education. This article briefly examines the rationales and strategies used by three countries in the Middle East and three in South East Asia which are working towards positioning themselves as regional education hubs. The different approaches and…

  14. Competition and coordination in the U.S. airline hub-to-hub markets: An industry pre-merger case study

    Directory of Open Access Journals (Sweden)

    Prasun Bhattacharjee

    2016-04-01

    Full Text Available Purpose: This paper investigates the nature of conduct that existed in the U.S. airline hub-to-hub markets prior to the recent merger wave of the legacy carriers. We explore the strategic importance of network carrier hubs in form of “spheres of influence” on airline market conduct. We also simultaneously recognize the overgrowing role played by Low Cost Carriers (LCC over the years by estimating two conduct parameters - one in markets where LCCs directly compete head-to-head with legacy carriers and the other for markets which LCCs do not serve but has presence in the hub airports or adjacent airports comprising the market endpoints. Thus our supply side framework also sheds some light on the issue of perfect contestability in airline industry. Design/methodology/approach: We estimate a structural oligopoly model for differentiated products with competitive interactions using DB1B data for first quarter of 2004. Findings: Our results imply that the nature of competition is more aggressive relative to Bertrand behavior in hub-to-hub markets and that these markets are less than perfectly contestable. Originality/value: This paper adds to the empirical literature of airline competition by enabling estimation of the actual conduct parameter assuming firm price setting behavior in presence of product differentiation. Contrary to existing literature on airline competition, a structural model enables us to systematically separate out effects of demand, cost and strategic factors on observed airline prices.

  15. Features analysis for identification of date and party hubs in protein interaction network of Saccharomyces Cerevisiae

    Directory of Open Access Journals (Sweden)

    Araabi Babak N

    2010-12-01

    Full Text Available Abstract Background It has been understood that biological networks have modular organizations which are the sources of their observed complexity. Analysis of networks and motifs has shown that two types of hubs, party hubs and date hubs, are responsible for this complexity. Party hubs are local coordinators because of their high co-expressions with their partners, whereas date hubs display low co-expressions and are assumed as global connectors. However there is no mutual agreement on these concepts in related literature with different studies reporting their results on different data sets. We investigated whether there is a relation between the biological features of Saccharomyces Cerevisiae's proteins and their roles as non-hubs, intermediately connected, party hubs, and date hubs. We propose a classifier that separates these four classes. Results We extracted different biological characteristics including amino acid sequences, domain contents, repeated domains, functional categories, biological processes, cellular compartments, disordered regions, and position specific scoring matrix from various sources. Several classifiers are examined and the best feature-sets based on average correct classification rate and correlation coefficients of the results are selected. We show that fusion of five feature-sets including domains, Position Specific Scoring Matrix-400, cellular compartments level one, and composition pairs with two and one gaps provide the best discrimination with an average correct classification rate of 77%. Conclusions We study a variety of known biological feature-sets of the proteins and show that there is a relation between domains, Position Specific Scoring Matrix-400, cellular compartments level one, composition pairs with two and one gaps of Saccharomyces Cerevisiae's proteins, and their roles in the protein interaction network as non-hubs, intermediately connected, party hubs and date hubs. This study also confirms the

  16. Effective spectral dimension of hub in scale-free networks

    Science.gov (United States)

    Hwang, Sungmin; Lee, Deok-Sun; Kahng, Byungnam

    2012-02-01

    Exploring the World Wide Web has become one of the key issues in information science, specifically in context of its application to the PageRank-like algorithms used in search engine. The random walk approach has been employed to study such a problem. The probability of the return to the origin (RTO) of random walks is inversely related to how information can be accessed during random surfing. We find analytically that the RTO probability for a given starting node shows a crossover from a slow to a fast decay behavior with time and the crossover time increases with the degree of the starting node. Furthermore, the RTO probability is almost constant in the early-time regime as the degree exponent approaches two. This result indicates that a random surfer can be effectively trapped at the hub and supports the necessity of the random jump strategy empirically used in the Google's search engine.

  17. Paneth cells: the hub for sensing and regulating intestinal flora.

    Science.gov (United States)

    Zhang, Zheng; Liu, Zhihua

    2016-05-01

    The complex interplay between symbiotic bacteria and host immunity plays a key role in shaping intestinal homeostasis and maintaining host health. Paneth cells, as one of the major producers of antimicrobial peptides in the intestine under steady-state conditions, play a vital role in regulating intestinal flora. Many studies on inflammatory bowel disease (IBD)-associated genes have put Paneth cells at the center of IBD pathogenesis. In this perspective, we focus on mechanistic studies of different cellular processes in Paneth cells that are regulated by various IBD-associated susceptibility genes, and we discuss the hypothesis that Paneth cells function as the central hub for sensing and regulating intestinal flora in the maintenance of intestinal homeostasis.

  18. A Collaborative Scheduling Model for the Supply-Hub with Multiple Suppliers and Multiple Manufacturers

    Directory of Open Access Journals (Sweden)

    Guo Li

    2014-01-01

    Full Text Available This paper investigates a collaborative scheduling model in the assembly system, wherein multiple suppliers have to deliver their components to the multiple manufacturers under the operation of Supply-Hub. We first develop two different scenarios to examine the impact of Supply-Hub. One is that suppliers and manufacturers make their decisions separately, and the other is that the Supply-Hub makes joint decisions with collaborative scheduling. The results show that our scheduling model with the Supply-Hub is a NP-complete problem, therefore, we propose an auto-adapted differential evolution algorithm to solve this problem. Moreover, we illustrate that the performance of collaborative scheduling by the Supply-Hub is superior to separate decision made by each manufacturer and supplier. Furthermore, we also show that the algorithm proposed has good convergence and reliability, which can be applicable to more complicated supply chain environment.

  19. Hub Identification of the Metro Manila Road Network Using PageRank

    CERN Document Server

    Chan, Jacob

    2016-01-01

    We attempt to identify the different node hubs of a road network using PageRank for preparation for possible random terrorist attacks. The robustness of a road network against such attack is crucial to be studied because it may cripple its connectivity by simply shutting down these hubs. We show the important hubs in a road network based on network structure and propose a model for robustness analysis. By identifying important hubs in a road network, possible preparation schemes may be done earlier to mitigate random terrorist attacks, including defense reinforcement and transportation security. A case study of the Metro Manila road network is also presented. The case study shows that the most important hubs in the Metro Manila road network are near airports, piers, major highways and expressways

  20. A Fractal and Scale-free Model of Complex Networks with Hub Attraction Behaviors

    CERN Document Server

    Kuang, Li; Li, Deyi; Li, Yuanxiang; Sun, Yu

    2013-01-01

    It is widely believed that fractality of complex networks origins from hub repulsion behaviors (anticorrelation or disassortativity), which means large degree nodes tend to connect with small degree nodes. This hypothesis was demonstrated by a dynamical growth model, which evolves as the inverse renormalization procedure proposed by Song et al. Now we find that the dynamical growth model is based on the assumption that all the cross-boxes links has the same probability e to link to the most connected nodes inside each box. Therefore, we modify the growth model by adopting the flexible probability e, which makes hubs have higher probability to connect with hubs than non-hubs. With this model, we find some fractal and scale-free networks have hub attraction behaviors (correlation or assortativity). The results are the counter-examples of former beliefs.

  1. MODELS AND METHODS FOR LOGISTICS HUB LOCATION: A REVIEW TOWARDS TRANSPORTATION NETWORKS DESIGN

    Directory of Open Access Journals (Sweden)

    Carolina Luisa dos Santos Vieira

    Full Text Available ABSTRACT Logistics hubs affect the distribution patterns in transportation networks since they are flow-concentrating structures. Indeed, the efficient moving of goods throughout supply chains depends on the design of such networks. This paper presents a literature review on the logistics hub location problem, providing an outline of modeling approaches, solving techniques, and their applicability to such context. Two categories of models were identified. While multi-criteria models may seem best suited to find optimal locations, they do not allow an assessment of the impact of new hubs on goods flow and on the transportation network. On the other hand, single-criterion models, which provide location and flow allocation information, adopt network simplifications that hinder an accurate representation of the relationshipbetween origins, destinations, and hubs. In view of these limitations we propose future research directions for addressing real challenges of logistics hubs location regarding transportation networks design.

  2. Height and Tilt Geometric Texture

    DEFF Research Database (Denmark)

    Andersen, Vedrana; Desbrun, Mathieu; Bærentzen, Jakob Andreas

    2009-01-01

    We propose a new intrinsic representation of geometric texture over triangle meshes. Our approach extends the conventional height field texture representation by incorporating displacements in the tangential plane in the form of a normal tilt. This texture representation offers a good practical...... compromise between functionality and simplicity: it can efficiently handle and process geometric texture too complex to be represented as a height field, without having recourse to full blown mesh editing algorithms. The height-and-tilt representation proposed here is fully intrinsic to the mesh, making...

  3. USDA Southwest Regional Hub for Adaptation to and Mitigation of Climate Change

    Science.gov (United States)

    Rango, A.; Elias, E.; Steele, C. M.; Havstad, K.

    2014-12-01

    The USDA Southwest (SW) Climate Hub was created in February 2014 to develop risk adaptation and mitigation strategies for coping with climate change effects on agricultural productivity. There are seven regional hubs across the country with three subsidiary hubs. The SW Climate Hub Region is made up of six states: New Mexico, Arizona, Utah, Nevada, California and Hawaii (plus the Trust Territories of the Pacific Islands). The SW Climate Hub has a subsidiary hub located in Davis, California. The Southwest region has high climatic diversity, with the lowest and highest average annual rainfall in the U.S.(6.0 cm in Death Valley, CA and 1168 cm at Mt. Waialeale, HI). There are major deserts in five of the six states, yet most of the states, with exception of Hawaii, depend upon the melting of mountain snowpacks for their surface water supply. Additionally, many of the agricultural areas of the SW Regional Hub depend upon irrigation water to maintain productivity. Scientific climate information developed by the Hub will be used for climate-smart decision making. To do this, the SW Regional Hub will rely upon existing infrastructure of the Cooperative Extension Service at Land-Grant State Universities. Extension service and USDA-NRCS personnel have existing networks to communicate with stakeholders (farmers, ranchers, and forest landowners) through meetings and workshops which have already started in the six states. Outreach through the development of a weather and climate impact modules designed for seventh grade students and their teachers will foster education of future generations of rural land managers. We will be synthesizing and evaluating existing reports, literature and information on regional climate projections, water resources, and agricultural adaptation strategies related to climate in the Southwest. The results will be organized in a spatial format and provided through the SW Hub website (http://swclimatehub.info) and peer-reviewed articles.

  4. The noise generated by a landing gear wheel with hub and rim cavities

    Science.gov (United States)

    Wang, Meng; Angland, David; Zhang, Xin

    2017-03-01

    Wheels are one of the major noise sources of landing gears. Accurate numerical predictions of wheel noise can provide an insight into the physical mechanism of landing gear noise generation and can aid in the design of noise control devices. The major noise sources of a 33% scaled isolated landing gear wheel are investigated by simulating three different wheel configurations using high-order numerical simulations to compute the flow field and the FW-H equation to obtain the far-field acoustic pressures. The baseline configuration is a wheel with a hub cavity and two rim cavities. Two additional simulations are performed; one with the hub cavity covered (NHC) and the other with both the hub cavity and rim cavities covered (NHCRC). These simulations isolate the effects of the hub cavity and rim cavities on the overall wheel noise. The surface flow patterns are visualised by shear stress lines and show that the flow separations and attachments on the side of the wheel, in both the baseline and the configuration with only the hub cavity covered, are significantly reduced by covering both the hub and rim cavities. A frequency-domain FW-H equation is used to identify the noise source regions on the surface of the wheel. The tyre is the main low frequency noise source and shows a lift dipole and side force dipole pattern depending on the frequency. The hub cavity is identified as the dominant middle frequency noise source and radiates in a frequency range centered around the first and second depth modes of the cylindrical hub cavity. The rim cavities are the main high-frequency noise sources. With the hub cavity and rim cavities covered, the largest reduction in Overall Sound Pressure Level (OASPL) is achieved in the hub side direction. In the other directivities, there is also a reduction in the radiated sound.

  5. Measuring perceived ceiling height in a visual comparison task.

    Science.gov (United States)

    von Castell, Christoph; Hecht, Heiko; Oberfeld, Daniel

    2017-03-01

    When judging interior space, a dark ceiling is judged to be lower than a light ceiling. The method of metric judgments (e.g., on a centimetre scale) that has typically been used in such tasks may reflect a genuine perceptual effect or it may reflect a cognitively mediated impression. We employed a height-matching method in which perceived ceiling height had to be matched with an adjustable pillar, thus obtaining psychometric functions that allowed for an estimation of the point of subjective equality (PSE) and the difference limen (DL). The height-matching method developed in this paper allows for a direct visual match and does not require metric judgment. It has the added advantage of providing superior precision. Experiment 1 used ceiling heights between 2.90 m and 3.00 m. The PSE proved sensitive to slight changes in perceived ceiling height. The DL was about 3% of the physical ceiling height. Experiment 2 found similar results for lower (2.30 m to 2.50 m) and higher (3.30 m to 3.50 m) ceilings. In Experiment 3, we additionally varied ceiling lightness (light grey vs. dark grey). The height matches showed that the light ceiling appeared significantly higher than the darker ceiling. We therefore attribute the influence of ceiling lightness on perceived ceiling height to a direct perceptual rather than a cognitive effect.

  6. Alaska Geoid Heights (GEOID96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' x 4' geoid height grid for Alaska is distributed as a GEOID96 model. The computation used 1.1 million terrestrial and marine gravity data held in the...

  7. Mexico Geoid Heights (MEXICO97)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' geoid height grid for Mexico, and North-Central America, is the MEXICO97 geoid model. The computation used about one million terrestrial and marine gravity...

  8. A Multi-Objective, Hub-and-Spoke Supply Chain Design Model for Densified Biomass

    Energy Technology Data Exchange (ETDEWEB)

    Jacob J. Jacobson; Md. S. Roni; Kara G. Cafferty; Sandra D. Eksioglu

    2014-06-01

    In this paper we propose a model to design the supply chain for densified biomass. Rail is typically used for longhaul, high-volume shipment of densified biomass. This is the reason why a hub-and-spoke network structure is used to model this supply chain. The model is formulated as a multi-objective, mixed-integer programing problem under economic, environmental, and social criteria. The goal is to identify the feasibility of meeting the Renewable Fuel Standard (RFS) by using biomass for production of cellulosic ethanol. The focus is not just on the costs associated with meeting these standards, but also exploring the social and environmental benefits that biomass production and processing offers by creating new jobs and reducing greenhouse gas (GHG) emissions. We develop an augmented ?-constraint method to find the exact Pareto solution to this optimization problem. We develop a case study using data from the Mid-West. The model identifies the number, capacity and location of biorefineries needed to make use of the biomass available in the region. The model estimates the delivery cost of cellulosic ethanol under different scenario, the number new jobs created and the GHG emission reductions in the supply chain.

  9. A Multi-Objective, Hub-and-Spoke Supply Chain Design Model For Densified Biomass

    Energy Technology Data Exchange (ETDEWEB)

    Md S. Roni; Sandra Eksioglu; Kara G. Cafferty

    2014-06-01

    In this paper we propose a model to design the supply chain for densified biomass. Rail is typically used for long-haul, high-volume shipment of densified biomass. This is the reason why a hub-and-spoke network structure is used to model this supply chain. The model is formulated as a multi-objective, mixed-integer programing problem under economic, environmental, and social criteria. The goal is to identify the feasibility of meeting the Renewable Fuel Standard (RFS) by using biomass for production of cellulosic ethanol. The focus in not just on the costs associated with meeting these standards, but also exploring the social and environmental benefits that biomass production and processing offers by creating new jobs and reducing greenhouse gas (GHG) emissions. We develop an augmented ?-constraint method to find the exact Pareto solution to this optimization problem. We develop a case study using data from the Mid-West. The model identifies the number, capacity and location of biorefineries needed to make use of the biomass available in the region. The model estimates the delivery cost of cellulosic ethanol under different scenario, the number new jobs created and the GHG emission reductions in the supply chain.

  10. Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation

    Directory of Open Access Journals (Sweden)

    João Ricardo Sato

    2016-08-01

    Full Text Available Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7–15 years old; total N = 652; 341 subjects for site 1 and 311 for site 2 to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS. Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.

  11. Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation.

    Science.gov (United States)

    Sato, João Ricardo; Biazoli, Claudinei Eduardo; Salum, Giovanni Abrahão; Gadelha, Ary; Crossley, Nicolas; Vieira, Gilson; Zugman, André; Picon, Felipe Almeida; Pan, Pedro Mario; Hoexter, Marcelo Queiroz; Anés, Mauricio; Moura, Luciana Monteiro; Del'Aquilla, Marco Antonio Gomes; Junior, Edson Amaro; Mcguire, Philip; Rohde, Luis Augusto; Miguel, Euripedes Constantino; Bressan, Rodrigo Affonseca; Jackowski, Andrea Parolin

    2016-08-01

    Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7-15 years old; total N=652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.

  12. Incremental Optimization of Hub and Spoke Network for the Spokes’ Numbers and Flow

    Directory of Open Access Journals (Sweden)

    Yanfeng Wang

    2015-01-01

    Full Text Available Hub and spoke network problem is solved as part of a strategic decision making process which may have a profound effect on the future of enterprises. In view of the existing network structure, as time goes on, the number of spokes and the flow change because of different sources of uncertainty. Hence, the incremental optimization of hub and spoke network problem is considered in this paper, and the policy makers should adopt a series of strategies to cope with the change, such as setting up new hubs, adjusting the capacity level of original hubs, or closing some original hubs. The objective is to minimize the total cost, which includes the setup costs for the new hubs, the closure costs, and the adjustment costs for the original hubs as well as the flow routing costs. Two mixed-integer linear programming formulations are proposed and analyzed for this problem. China Deppon Logistics as an example is performed to present computational analysis, and we analyze the changes in the solutions driven by the number of spokes and the flow. The tests also allow an analysis to consider the effect of variation in parameters on network.

  13. Fatigue based design and analysis of wheel hub for Student formula car by Simulation Approach

    Science.gov (United States)

    Gowtham, V.; Ranganathan, A. S.; Satish, S.; Alexis, S. John; Siva kumar, S.

    2016-09-01

    In the existing design of Wheel hub used for Student formula cars, the brake discs cannot be removed easily since the disc is mounted in between the knuckle and hub. In case of bend or any other damage to the disc, the replacement of the disc becomes difficult. Further using OEM hub and knuckle that are used for commercial vehicles will result in increase of unsprung mass, which should be avoided in Student formula cars for improving the performance. In this design the above mentioned difficulties have been overcome by redesigning the hub in such a way that the brake disc could be removed easily by just removing the wheel and the caliper and also it will have reduced weight when compared to existing OEM hub. A CAD Model was developed based on the required fatigue life cycles. The forces acting on the hub were calculated and linear static structural analysis was performed on the wheel hub for three different materials using ANSYS Finite Element code V 16.2. The theoretical fatigue strength was compared with the stress obtained from the structural analysis for each material.

  14. A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole.

    Science.gov (United States)

    Yamaichi, Yoshiharu; Bruckner, Raphael; Ringgaard, Simon; Möll, Andrea; Cameron, D Ewen; Briegel, Ariane; Jensen, Grant J; Davis, Brigid M; Waldor, Matthew K

    2012-10-15

    The cell poles constitute key subcellular domains that are often critical for motility, chemotaxis, and chromosome segregation in rod-shaped bacteria. However, in nearly all rods, the processes that underlie the formation, recognition, and perpetuation of the polar domains are largely unknown. Here, in Vibrio cholerae, we identified HubP (hub of the pole), a polar transmembrane protein conserved in all vibrios, that anchors three ParA-like ATPases to the cell poles and, through them, controls polar localization of the chromosome origin, the chemotactic machinery, and the flagellum. In the absence of HubP, oriCI is not targeted to the cell poles, chemotaxis is impaired, and a small but increased fraction of cells produces multiple, rather than single, flagella. Distinct cytoplasmic domains within HubP are required for polar targeting of the three ATPases, while a periplasmic portion of HubP is required for its localization. HubP partially relocalizes from the poles to the mid-cell prior to cell division, thereby enabling perpetuation of the polar domain in future daughter cells. Thus, a single polar hub is instrumental for establishing polar identity and organization.

  15. Hubs and authorities in the world trade network using a weighted HITS algorithm.

    Science.gov (United States)

    Deguchi, Tsuyoshi; Takahashi, Katsuhide; Takayasu, Hideki; Takayasu, Misako

    2014-01-01

    We investigate the economic hubs and authorities of the world trade network (WTN) from 1992 to 2012, an era of rapid economic globalization. Using a well-defined weighted hyperlink-induced topic search (HITS) algorithm, we can calculate the values of the weighted HITS hub and authority for each country in a conjugate way. In the context of the WTN, authority values are large for countries with significant imports from large hub countries, and hub values are large for countries with significant exports to high-authority countries. The United States was the largest economic authority in the WTN from 1992 to 2012. The authority value of the United States has declined since 2001, and China has now become the largest hub in the WTN. At the same time, China's authority value has grown as China is transforming itself from the "factory of the world" to the "market of the world." European countries show a tendency to trade mostly within the European Union, which has decreased Europe's hub and authority values. Japan's authority value has increased slowly, while its hub value has declined. These changes are consistent with Japan's transition from being an export-driven economy in its high economic growth era in the latter half of the twentieth century to being a more mature, economically balanced nation.

  16. Hubs and authorities in the world trade network using a weighted HITS algorithm.

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Deguchi

    Full Text Available We investigate the economic hubs and authorities of the world trade network (WTN from 1992 to 2012, an era of rapid economic globalization. Using a well-defined weighted hyperlink-induced topic search (HITS algorithm, we can calculate the values of the weighted HITS hub and authority for each country in a conjugate way. In the context of the WTN, authority values are large for countries with significant imports from large hub countries, and hub values are large for countries with significant exports to high-authority countries. The United States was the largest economic authority in the WTN from 1992 to 2012. The authority value of the United States has declined since 2001, and China has now become the largest hub in the WTN. At the same time, China's authority value has grown as China is transforming itself from the "factory of the world" to the "market of the world." European countries show a tendency to trade mostly within the European Union, which has decreased Europe's hub and authority values. Japan's authority value has increased slowly, while its hub value has declined. These changes are consistent with Japan's transition from being an export-driven economy in its high economic growth era in the latter half of the twentieth century to being a more mature, economically balanced nation.

  17. 合成气中枢%Syngas Hub

    Institute of Scientific and Technical Information of China (English)

    徐恒泳; 葛庆杰; 李文钊

    2011-01-01

    回顾了人类使用化石能源所经历的煤(固体)、石油(液体)和天然气(气体)燃料的3个时期.针对近年来环境安全和能源清洁化日益重要,而化石能源仍占世界能源主要消费结构的现状,提出了“合成气中枢”的新概念.重点介绍了从天然气、煤和生物质等多种原料气化生产合成气并进行组成调变;煤基和天然气基合成气制化学品的差别;合成气的转化利用,特别是在发电和热-电-化学品多联产、制取清洁燃料和烯烃以及制取代用天然气等方面的研究进展并进行了评述.认为合成气中枢将成为连接石油炼制、石油化工、天然气化工和煤化工以及电力行业的桥梁,有利于资源和能量的最佳利用以及CO2减排.%The consumption history of fossil energy sources including coal ( solid), petroleum (liquid) and natural gas (gas) was briefly reviewed. Although the seeking for non-fossil energy sources is becoming urgent due to the more and more serious global warming, the fossil energy sources will still occupy more than 50% of the global energy consumption before 2050. Therefore, the concept of syngas hub was brought forward, and the following aspects were emphasized in this review: syngas production and its composition adjustment, the difference of syngas to chemicals from coal and natural gas, and syngas conversion and utilization. It was thought that the syngas hub will become a bridge which connects petroleum refining, petrochemical industry, natural gas chemical industry, coal chemical industry and electric power industry, and is further beneficial to the low CO2 emission and the optimal utilization of resources and energy sources.

  18. On the Popularity of GitHub Applications: A Preliminary Note

    OpenAIRE

    Borges, Hudson; Valente, Marco Tulio; Hora, Andre; Coelho, Jailton

    2015-01-01

    GitHub is the world's largest collection of open source software. Therefore, it is important both to software developers and users to compare and track the popularity of GitHub repositories. In this paper, we propose a framework to assess the popularity of GitHub software, using their number of stars. We also propose a set of popularity growth patterns, which describe the evolution of the number of stars of a system over time. We show that stars tend to correlate with other measures, like for...

  19. The typical behaviour of relays

    OpenAIRE

    Alamino, Roberto C.; Saad, David

    2007-01-01

    The typical behaviour of the relay-without-delay channel and its many-units generalisation, termed the relay array, under LDPC coding, is studied using methods of statistical mechanics. A demodulate-and-forward strategy is analytically solved using the replica symmetric ansatz which is exact in the studied system at the Nishimori's temperature. In particular, the typical level of improvement in communication performance by relaying messages is shown in the case of small and large number of re...

  20. Glacial effects limiting mountain height.

    Science.gov (United States)

    Egholm, D L; Nielsen, S B; Pedersen, V K; Lesemann, J-E

    2009-08-13

    The height of mountain ranges reflects the balance between tectonic rock uplift, crustal strength and surface denudation. Tectonic deformation and surface denudation are interdependent, however, and feedback mechanisms-in particular, the potential link to climate-are subjects of intense debate. Spatial variations in fluvial denudation rate caused by precipitation gradients are known to provide first-order controls on mountain range width, crustal deformation rates and rock uplift. Moreover, limits to crustal strength are thought to constrain the maximum elevation of large continental plateaus, such as those in Tibet and the central Andes. There are indications that the general height of mountain ranges is also directly influenced by the extent of glaciation through an efficient denudation mechanism known as the glacial buzzsaw. Here we use a global analysis of topography and show that variations in maximum mountain height correlate closely with climate-controlled gradients in snowline altitude for many high mountain ranges across orogenic ages and tectonic styles. With the aid of a numerical model, we further demonstrate how a combination of erosional destruction of topography above the snowline by glacier-sliding and commensurate isostatic landscape uplift caused by erosional unloading can explain observations of maximum mountain height by driving elevations towards an altitude window just below the snowline. The model thereby self-consistently produces the hypsometric signature of the glacial buzzsaw, and suggests that differences in the height of mountain ranges mainly reflect variations in local climate rather than tectonic forces.

  1. Encounter Probability of Significant Wave Height

    DEFF Research Database (Denmark)

    Liu, Z.; Burcharth, H. F.

    The determination of the design wave height (often given as the significant wave height) is usually based on statistical analysis of long-term extreme wave height measurement or hindcast. The result of such extreme wave height analysis is often given as the design wave height corresponding to a c...

  2. Testing typicality in multiverse cosmology

    Science.gov (United States)

    Azhar, Feraz

    2015-05-01

    In extracting predictions from theories that describe a multiverse, we face the difficulty that we must assess probability distributions over possible observations prescribed not just by an underlying theory, but by a theory together with a conditionalization scheme that allows for (anthropic) selection effects. This means we usually need to compare distributions that are consistent with a broad range of possible observations with actual experimental data. One controversial means of making this comparison is by invoking the "principle of mediocrity": that is, the principle that we are typical of the reference class implicit in the conjunction of the theory and the conditionalization scheme. In this paper, we quantitatively assess the principle of mediocrity in a range of cosmological settings, employing "xerographic distributions" to impose a variety of assumptions regarding typicality. We find that for a fixed theory, the assumption that we are typical gives rise to higher likelihoods for our observations. If, however, one allows both the underlying theory and the assumption of typicality to vary, then the assumption of typicality does not always provide the highest likelihoods. Interpreted from a Bayesian perspective, these results support the claim that when one has the freedom to consider different combinations of theories and xerographic distributions (or different "frameworks"), one should favor the framework that has the highest posterior probability; and then from this framework one can infer, in particular, how typical we are. In this way, the invocation of the principle of mediocrity is more questionable than has been recently claimed.

  3. Transport of pollutants and sediment in the area of the Wave Hub (Celtic Sea)

    Science.gov (United States)

    Shapiro, Georgy; Huntley, David

    2010-05-01

    consequences. This paper presents some preliminary modelling results of a baseline study focussed on hind-cast and now-cast simulation of the 3D structure of temperature, salinity and current velocity in the area immediately adjacent to the location of the Wave Hub. Of the range of available 3D numerical models for shelf sea hydrodynamics, we have selected the Proudman Oceanographic Laboratory Coastal Modelling System (POLCOMS). The POLCOMS has successfully been used in a number of coastal/shelf sea regions to simulate circulation of coastal waters. Modelling is carried out in the region of approximately 200x 200 km with the variable vertical resolution typically less than 2 m. Such parameters allow resololution of the formation of coastal density fronts both within and outside the wave shadow zone, expected to be of the order of tens of kilometres. The meteorological parameters are obtained from the publicly available NCEP re-analyses data base. These parameters include components of the wind velocity and the surface heat fluxes, air pressure at sea level; temperature and humidity in the low troposphere; precipitation and cloudiness. In this study, the transport of pollution is simulated by a number of passive drifters located at a certain depth at a number of locations including the central point of the Wave Hub. Sediment transport is modelled using the Engelund-Hansen algorithm taking the current velocities produced by the POLCOMS as an input parameter. The Celtic sea is a tidally dominated region, and the modelling is run both in full-forcing and in tide-only modes in order to assess effects of density fronts on the residual (tidally averaged) circulation pattern. The results show that the pollution pathways are very sensitive to the formation of temperature fronts. In some cases the passive traces move in nearly opposite directions when the effect of temperature fronts is disregarded. Sediment transport is highly non-uniform spatially with some four areas along the

  4. Height and Breast Cancer Risk

    DEFF Research Database (Denmark)

    Zhang, Ben; Shu, Xiao-Ou; Delahanty, Ryan J

    2015-01-01

    BACKGROUND: Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear. METHODS: We performed a meta......-analysis to investigate associations between height and breast cancer risk using data from 159 prospective cohorts totaling 5216302 women, including 113178 events. In a consortium with individual-level data from 46325 case patients and 42482 control patients, we conducted a Mendelian randomization analysis using...... a genetic score that comprised 168 height-associated variants as an instrument. This association was further evaluated in a second consortium using summary statistics data from 16003 case patients and 41335 control patients. RESULTS: The pooled relative risk of breast cancer was 1.17 (95% confidence...

  5. replacing orthometric heights with ellipsoidal heights in engineering ...

    African Journals Online (AJOL)

    user

    This work investigates the use of ellipsoidal heights in place of orthometric ... be represented mathematically, and therefore enables computation to be .... suitable locations along the levelling routes. The ..... 5.3 Assumptions and theoretical approximations made ... tectonics movement, deformation and land subsidence.

  6. Tree Height Calculator: An Android App for Estimating Tree Height

    Science.gov (United States)

    Burca, V. S.; Htet, N. M.; Huang, X.; de Lanerolle, T. R.; Morelli, R.; Gourley, J. R.

    2011-12-01

    Conventionally, measuring tree height requires a collection of different tools - clinometer, transit, pencil, paper, laptop computer. Results are recorded manually and entered into a spreadsheet or database for future calculation and analysis. Tree Height Calculator is a mobile Android app the integrates the various steps in this process thereby improving the accuracy and dramatically reducing the time required to go from taking measurements to analyzing data. Given the user's height and the distance from the base of the tree (which can be downloaded into the app from a server), the app uses the phone's orientation sensor to calculate the angle of elevation. A simple trigonometric formula is then used to calculate and record the tree's height in the phone's database. When the phone has a WiFi connection, the data are transmitted to a server, from where they can be downloaded directly into a spreadsheet. The application was first tested in an Environmental Science laboratory at Trinity College. On the first trial, 103 data samples were collected, stored, and uploaded to the online database with only couple of dropped data points. On the second trial, 98 data samples were gathered with no loss of data. The app combined the individual measurements taken by the students in the lab, reducing the time required to produce a graph of the class's results from days to hours.

  7. Assessing wave energy effects on biodiversity: the wave hub experience.

    Science.gov (United States)

    Witt, M J; Sheehan, E V; Bearhop, S; Broderick, A C; Conley, D C; Cotterell, S P; Crow, E; Grecian, W J; Halsband, C; Hodgson, D J; Hosegood, P; Inger, R; Miller, P I; Sims, D W; Thompson, R C; Vanstaen, K; Votier, S C; Attrill, M J; Godley, B J

    2012-01-28

    Marine renewable energy installations harnessing energy from wind, wave and tidal resources are likely to become a large part of the future energy mix worldwide. The potential to gather energy from waves has recently seen increasing interest, with pilot developments in several nations. Although technology to harness wave energy lags behind that of wind and tidal generation, it has the potential to contribute significantly to energy production. As wave energy technology matures and becomes more widespread, it is likely to result in further transformation of our coastal seas. Such changes are accompanied by uncertainty regarding their impacts on biodiversity. To date, impacts have not been assessed, as wave energy converters have yet to be fully developed. Therefore, there is a pressing need to build a framework of understanding regarding the potential impacts of these technologies, underpinned by methodologies that are transferable and scalable across sites to facilitate formal meta-analysis. We first review the potential positive and negative effects of wave energy generation, and then, with specific reference to our work at the Wave Hub (a wave energy test site in southwest England, UK), we set out the methodological approaches needed to assess possible effects of wave energy on biodiversity. We highlight the need for national and international research clusters to accelerate the implementation of wave energy, within a coherent understanding of potential effects-both positive and negative.

  8. Proof test of hybrid shrink fits with ceramic hub

    Science.gov (United States)

    Wagner, M.; Binz, H.

    2011-10-01

    Advanced ceramic machine components are required in many applications because of their specific material properties like high hardness, resistance to chemicals, corrosion and wear, low specific weight etc. The most suitable shaft-hub connection to ceramics is an interference fit assembly because it is free of geometrical notches and transmission of forces takes place in a large area. Such a shrink fit is rated for endurance strength when the stress intensity factor is below the specific value KI0 where no crack growth occurs. The total component suddenly fails, when the stress intensity factor exceeds the KIC value. The load to the press fit during the joining process, caused by the interference of the assembly, could be regulated by ambient conditions. In case of undetected material defects or microcracks in the ceramic and if the stress intensity is below KIC, the ceramic will not fail but a crack could grow. Thus, the joining process only seems to be a proof test. When the load during operation leads to a stress intensity that remains higher than KI0 the crack grows until the whole ceramic component fails. This effect was verified in tests at the Institute for Engineering Design and Industrial Design.

  9. Proof test of hybrid shrink fits with ceramic hub

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, M; Binz, H, E-mail: markus.wagner@iktd.uni-stuttgart.de [Institute for Engineering Design and Industrial Design, University of Stuttgart (Germany)

    2011-10-29

    Advanced ceramic machine components are required in many applications because of their specific material properties like high hardness, resistance to chemicals, corrosion and wear, low specific weight etc. The most suitable shaft-hub connection to ceramics is an interference fit assembly because it is free of geometrical notches and transmission of forces takes place in a large area. Such a shrink fit is rated for endurance strength when the stress intensity factor is below the specific value K{sub I0} where no crack growth occurs. The total component suddenly fails, when the stress intensity factor exceeds the K{sub IC} value. The load to the press fit during the joining process, caused by the interference of the assembly, could be regulated by ambient conditions. In case of undetected material defects or microcracks in the ceramic and if the stress intensity is below K{sub IC}, the ceramic will not fail but a crack could grow. Thus, the joining process only seems to be a proof test. When the load during operation leads to a stress intensity that remains higher than K{sub I0} the crack grows until the whole ceramic component fails. This effect was verified in tests at the Institute for Engineering Design and Industrial Design.

  10. Modelagem para localização de hubs no transporte de encomendas expressas Modelling for location hubs in the express cargo transport

    Directory of Open Access Journals (Sweden)

    Javier Antonio Timaná Alamo

    2006-12-01

    Full Text Available Na presente pesquisa se propõe um modelo matemático de programação linear com variáveis binárias 0/1, para projetar a configuração de uma rede de distribuição de encomendas expressas, visando minimizar os custos e garantindo um bom nível de serviço. O modelo, que é uma modificação da formulação proposta por O’Kelly, define as posições dos hubs, a alocação deles às demais instalações físicas e a construção de roteiros com apenas uma parada intermediária, o que confere mais agilidade ao atendimento da demanda de transporte de carga. Considera-se a instalação de um único hub maior (Hub Principal, que serve como ponto de transbordo para os fluxos de carga entre as distintas regiões de um território, e um conjunto de terminais regionais (mini-hubs, servindo como ponto de conexão, unicamente, para os fluxos de carga existentes em um determinado raio de cobertura. Foram propostas extensões que incluem uma restrição da capacidade operacional do Hub Principal, para evitar seu congestionamento, e duas diferentes estratégias de induzir o aumento de fluxo de carga manipulado pelos mini-hubs. O modelo proposto e suas extensões foram aplicados ao estudo de um caso real, obtendo-se resultados consistentes e uma redução significativa no custo total da rede de distribuição da empresa analisada.This study proposes a mathematical model of linear programming with binary variables 0/1 to project the configuration of a distribution network for express cargo which aims to minimize costs and guarantee a high level of service. The model, which is a modification of the formulation proposed by O’Kelly, defines the position of the hubs, their allocation regarding the other physical installations, and the building of itineraries with only one intermediate stop, which increases agility in meeting the demand of cargo transport. It assumes the installation of a single, major hub (Main Hub, which serves as the transfer point for

  11. Fear of heights in infants?

    Science.gov (United States)

    Adolph, Karen E; Kretch, Kari S; LoBue, Vanessa

    2014-02-01

    Based largely on the famous "visual cliff" paradigm, conventional wisdom is that crawling infants avoid crossing the brink of a dangerous drop-off because they are afraid of heights. However, recent research suggests that the conventional wisdom is wrong. Avoidance and fear are conflated, and there is no compelling evidence to support fear of heights in human infants. Infants avoid crawling or walking over an impossibly high drop-off because they perceive affordances for locomotion-the relations between their own bodies and skills and the relevant properties of the environment that make an action such as descent possible or impossible.

  12. Down on heights? One in three has visual height intolerance.

    Science.gov (United States)

    Huppert, Doreen; Grill, Eva; Brandt, Thomas

    2013-02-01

    The distressing phenomenon of visual height intolerance (vHI) occurs when a visual stimulus causes apprehension of losing control of balance and falling from some height. Epidemiological data of this condition in the general population are lacking. Assignment of prevalence, determinants, and compensation of vHI was performed in a cross-sectional epidemiological study of 3,517 individuals representing the German population. Life-time prevalence of vHI is 28 % (females 32 %). A higher prevalence is associated independently with a family history of vHI, anxiety disorders, migraine, or motion sickness susceptibility. Women aged 50-59 have a higher prevalence than younger women or men of all ages. Initial attacks occur most often (30 %) in the second decade; however, attacks can manifest throughout life. The main symptoms are fearfulness, inner agitation, a queasy-stomach feeling, subjective postural instability with to-and-fro vertigo, and weakness in the knees. Climbing a tower is the first most common precipitating stimulus; the spectrum of such stimuli widens with time in more than 50 % of afflicted individuals. The most frequent reaction to vHI is to avoid the triggering stimuli (>50 %); 11 % of susceptible individuals consult a doctor, most often a general practitioner, neurologist, ENT doctor, or psychiatrist. In brief, visual height intolerance affects one-third of the general population, considerably restricting the majority of these individuals in their daily activities. The data show that the two terms do not indicate a categorical distinction but rather a continuum from slight forms of visual height intolerance to the specific phobia of fear of heights.

  13. Canonical Height Functions For Monomial Maps

    CERN Document Server

    Lin, Jan-Li

    2012-01-01

    We show that the canonical height function defined by Silverman does not have the Northcott finiteness property in general. We develop a new canonical height function for monomial maps. In certain cases, this new canonical height function has nice properties.

  14. Disseminated typical bronchial carcinoid tumor

    Directory of Open Access Journals (Sweden)

    Novković Dobrivoje

    2013-01-01

    Full Text Available Introduction. Bronchial carcinoids belong to a rare type of lung tumors. If they do not expose outstanding neuroendocrine activity, they develop without clearly visible symptoms. They are often detected during a routine examination. According to their clinical pathological features, they are divided into typical and atypical tumors. Typical bronchial carcinoids metastasize to distant organs very rarely. Localized forms are effectively treated by surgery. The methods of conservative treatment should be applied in other cases. Case report. We presented a 65-year-old patient with carcinoid lung tumor detected by a routine examination. Additional analysis (chest X-ray, computed tomography of the chest, ultrasound of the abdomen, skeletal scintigraphy, bronhoscopy, histopathological analysis of the bioptate of bronchial tumor, as well as bronchial brushing cytology and immunohistochemical staining performed with markers specific for neuroendocrine tumor proved a morphologically typical lung carcinoid with dissemination to the liver and skeletal system, which is very rarely found in typical carcinoids. Conclusion. The presented case with carcinoid used to be showed morphological and pathohistological characteristics of typical bronchial carcinoid. With its metastasis to the liver and skeletal system it demonstrated unusual clinical course that used to be considered as rare phenomenon. Due to its frequent asymptomatic course and varied manifestation, bronchial carcinoid could be considered as a diagnostic challenge requiring a multidisciplinary approach.

  15. The hub wall boundary layer development and losses in an axial flow compressor rotor passage

    Science.gov (United States)

    Murthy, K. N. S.; Lakshminarayana, B.

    1987-02-01

    The hub wall boundary layer development in a compressor stage including the rotor passage is experimentally investigated. A miniature five-hole probe was employed to measure the hub wall boundary layer inside the inlet guide vane passage, upstream and far downstream of the rotor. The hub wall boundary layer inside the rotor passage was acquired using a rotating miniature five-hole probe. The boundary layer is well behaved upstream and far downstream of the rotor. The migration of the hub wall boundary layer towards the suction surface corner is observed. The limiting streamline angles and static pressure distribution across the stage were also measured. The mean velocity profiles and the integral properties upstream, inside and downstream of the rotor, and the losses are presented and interpreted.

  16. Numerical and Experimental Investigation of Heat Flow in Permanent Magnet Brushless DC Hub Motor

    DEFF Research Database (Denmark)

    Fasil, Muhammed; Plesner, Daniel; Walther, Jens Honore

    2014-01-01

    in the stator. The hub motor construction restricts the available conductive paths for heat dissipation from the stator to the ambient only through the shaft. In contrast to an internal rotor structure, where the stator winding losses are diffused via conduction, here convection plays a major role in loss...... dissipation. Therefore, a LP thermal model with improved convection modelling has been proposed to calculate the temperature of the components inside the hub motor. The developed model is validated with the FE thermal model and the test data. In addition, CFD tools has been used to accurately model...... the internal and the external flow as well as the convective heat transfer of the hub motor. Finally, an optimization study of the hub motor has been carried out using the CFD model to improve heat transfer from the stator....

  17. Collaborative Policy of the Supply-Hub for Assemble-to-Order Systems with Delivery Uncertainty

    Directory of Open Access Journals (Sweden)

    Guo Li

    2014-01-01

    Full Text Available This paper considers the collaborative mechanisms of the Supply-Hub in the Assemble-to-Order system (ATO system hereafter with upstream delivery uncertainty. We first propose a collaborative replenishment mechanism in the ATO system, and construct a replenishment model with delivery uncertainty in use of the Supply-Hub. After transforming the original model into a one-dimensional optimization problem, we derive the optimal assembly quantity and reorder point of each component. In order to enable the Supply-Hub to conduct collaborative replenishment with each supplier, the punishment and reward mechanisms are proposed. The numerical analysis illustrates that service level of the Supply-Hub is an increasing function of both punishment and reward factors. Therefore, by adjusting the two factors, suppliers’ incentives of collaborative replenishment can be significantly enhanced, and then the service level of whole ATO system can be improved.

  18. Puertos, espacio y globalización: el desarrollo de hubs en México

    Directory of Open Access Journals (Sweden)

    Carlos Daniel Martner Peyrelongue

    2010-01-01

    Full Text Available Los puertos hubs se presentan como el nuevo paradigma de desarrollo del transporte y el comercio marítimo internacional en la globalización. Prácticamente todos los países latinoamericanos anuncian megaproyectos para el desarrollo de puertos hubs en sus litorales, generando grandes expectativas de desarrollo regional, con un débil sustento tanto teórico como empírico. En este sentido, el presente trabajo busca contribuir a la caracterización del modelo de puertos hubs en países periféricos dentro de la economíamundo capitalista, aludiendo, en especial, al caso mexicano. Se trata de aportar elementos de análisis para reconocer, a grandes rasgos, las posibilidades del desarrollo de hubs en los litorales mexicanos, desde la perspectiva de los estudios regionales y la geografía del transporte.

  19. Empirical analysis on the human dynamics of blogging behavior on GitHub

    Science.gov (United States)

    Yan, Deng-Cheng; Wei, Zong-Wen; Han, Xiao-Pu; Wang, Bing-Hong

    2017-01-01

    GitHub is a social collaborative coding platform on which software developers not only collaborate on codes but also share knowledge through blogs using GitHub Pages. In this article, we analyze the blogging behavior of software developers on GitHub Pages. The results show that both the commit number and the inter-event time of two consecutive blogging actions follow heavy-tailed distribution. We further observe a significant variety of activity among individual developers, and a strongly positive correlation between the activity and the power-law exponent of the inter-event time distribution. We also find a difference between the user behaviors of GitHub Pages and other online systems which is driven by the diversity of users and length of contents. In addition, our result shows an obvious difference between the majority of developers and elite developers in their burstiness property.

  20. Sci-Hub: What Librarians Should Know and Do about Article Piracy.

    Science.gov (United States)

    Hoy, Matthew B

    2017-01-01

    The high cost of journal articles has driven many researchers to turn to a new way of getting access: "pirate" article sites. Sci-Hub, the largest and best known of these sites, currently offers instant access to more than 58 million journal articles. Users attracted by the ease of use and breadth of the collection may not realize that these articles are often obtained using stolen credentials and downloading them may be illegal. This article will briefly describe Sci-Hub and how it works, the legal and ethical issues it raises, and the problems it may cause for librarians. Librarians should be aware of Sci-Hub and the ways it may change their patrons' expectations. They should also understand the risks Sci-Hub can pose to their patrons and their institutions.

  1. Testing typicality in multiverse cosmology

    CERN Document Server

    Azhar, Feraz

    2015-01-01

    In extracting predictions from theories that describe a multiverse, we face the difficulty that we must assess probability distributions over possible observations, prescribed not just by an underlying theory, but by a theory together with a conditionalization scheme that allows for (anthropic) selection effects. This means we usually need to compare distributions that are consistent with a broad range of possible observations, with actual experimental data. One controversial means of making this comparison is by invoking the 'principle of mediocrity': that is, the principle that we are typical of the reference class implicit in the conjunction of the theory and the conditionalization scheme. In this paper, I quantitatively assess the principle of mediocrity in a range of cosmological settings, employing 'xerographic distributions' to impose a variety of assumptions regarding typicality. I find that for a fixed theory, the assumption that we are typical gives rise to higher likelihoods for our observations. I...

  2. Height-Deterministic Pushdown Automata

    DEFF Research Database (Denmark)

    Nowotka, Dirk; Srba, Jiri

    2007-01-01

    of regular languages and still closed under boolean language operations, are considered. Several of such language classes have been described in the literature. Here, we suggest a natural and intuitive model that subsumes all the formalisms proposed so far by employing height-deterministic pushdown automata...

  3. A Dynamic Calibration Method for Experimental and Analytical Hub Load Comparison

    Science.gov (United States)

    2017-03-01

    ARL-RP-0592 ● Mar 2017 US Army Research Laboratory A Dynamic Calibration Method for Experimental and Analytical Hub Load Comparison by Robert P... A Dynamic Calibration Method for Experimental and Analytical Hub Load Comparison by Robert P Thornburgh, Andrew R Kreshock, and Matthew L...other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a

  4. Typical errors of ESP users

    Science.gov (United States)

    Eremina, Svetlana V.; Korneva, Anna A.

    2004-07-01

    The paper presents analysis of the errors made by ESP (English for specific purposes) users which have been considered as typical. They occur as a result of misuse of resources of English grammar and tend to resist. Their origin and places of occurrence have also been discussed.

  5. A novel virtual hub approach for multisource downstream service integration

    Science.gov (United States)

    Previtali, Mattia; Cuca, Branka; Barazzetti, Luigi

    2016-08-01

    A large development of downstream services is expected to be stimulated starting from earth observations (EO) datasets acquired by Copernicus satellites. An important challenge connected with the availability of downstream services is the possibility for their integration in order to create innovative applications with added values for users of different categories level. At the moment, the world of geo-information (GI) is extremely heterogeneous in terms of standards and formats used, thus preventing a facilitated access and integration of downstream services. Indeed, different users and data providers have also different requirements in terms of communication protocols and technology advancement. In recent years, many important programs and initiatives have tried to address this issue even on trans-regional and international level (e.g. INSPIRE Directive, GEOSS, Eye on Earth and SEIS). However, a lack of interoperability between systems and services still exists. In order to facilitate the interaction between different downstream services, a new architectural approach (developed within the European project ENERGIC OD) is proposed in this paper. The brokering-oriented architecture introduces a new mediation layer (the Virtual Hub) which works as an intermediary to bridge the gaps linked to interoperability issues. This intermediation layer de-couples the server and the client allowing a facilitated access to multiple downstream services and also Open Data provided by national and local SDIs. In particular, in this paper an application is presented integrating four services on the topic of agriculture: (i) the service given by Space4Agri (providing services based on MODIS and Landsat data); (ii) Gicarus Lab (providing sample services based on Landsat datasets) and (iii) FRESHMON (providing sample services for water quality) and services from a several regional SDIs.

  6. NGC 281: A Bustling Hub of Star Formation

    Science.gov (United States)

    2005-01-01

    NGC 281 is a bustling hub of star formation about 10,000 light years away. This composite image of optical and X-ray emission includes regions where new stars are forming and older regions containing stars about 3 million years old. The optical data (seen in red, orange, and yellow) show a small open cluster of stars, large lanes of obscuring gas and dust, and dense knots where stars may still be forming. The X-ray data (purple), based on a Chandra observation lasting more than a day, shows a different view. More than 300 individual X-ray sources are seen, most of them associated with IC 1590, the central cluster. The edge-on aspect of NGC 281 allows scientists to study the effects of powerful X-rays on the gas in the region, the raw material for star formation. A second group of X-ray sources is seen on either side of a dense molecular cloud, known as NGC 281 West, a cool cloud of dust grains and gas, much of which is in the form of molecules. The bulk of the sources around the molecular cloud are coincident with emission from polycyclic aromatic hydrocarbons, a family of organic molecules containing carbon and hydrogen. There also appears to be cool diffuse gas associated with IC 1590 that extends toward NGC 281 West. The X-ray spectrum of this region shows that the gas is a few million degrees and contains significant amounts of magnesium, sulfur and silicon. The presence of these elements suggests that supernova recently went off in that area.

  7. and the CMJ jump height

    Directory of Open Access Journals (Sweden)

    Struzik Artur

    2016-04-01

    Full Text Available Study aim: The elastic potential energy accumulated in the musculotendinous units during the countermovement phase of a jump adds up to the energy supplied by the contracting muscles used in the take-off phase. Consequently, the total mechanical energy used during the jump may reach higher values. Stiffness represents a quantitative measure of a body’s elastic properties. Therefore, the aim of this study was to establish the relationship between leg stiffness and the countermovement jump height.

  8. Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour.

    Science.gov (United States)

    Bonnavion, Patricia; Mickelsen, Laura E; Fujita, Akie; de Lecea, Luis; Jackson, Alexander C

    2016-11-15

    The hypothalamus is among the most phylogenetically conserved regions in the vertebrate brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By integrating signals arising from both the brain and periphery, it governs a litany of behaviourally important functions essential for survival. In particular, the lateral hypothalamic area (LHA) is central to the orchestration of sleep-wake states, feeding, energy balance and motivated behaviour. Underlying these diverse functions is a heterogeneous assembly of cell populations typically defined by neurochemical markers, such as the well-described neuropeptides hypocretin/orexin and melanin-concentrating hormone. However, anatomical and functional evidence suggests a rich diversity of other cell populations with complex neurochemical profiles that include neuropeptides, receptors and components of fast neurotransmission. Collectively, the LHA acts as a hub for the integration of diverse central and peripheral signals and, through complex local and long-range output circuits, coordinates adaptive behavioural responses to the environment. Despite tremendous progress in our understanding of the LHA, defining the identity of functionally discrete LHA cell types, and their roles in driving complex behaviour, remain significant challenges in the field. In this review, we discuss advances in our understanding of the neurochemical and cellular heterogeneity of LHA neurons and the recent application of powerful new techniques, such as opto- and chemogenetics, in defining the role of LHA circuits in feeding, reward, arousal and stress. From pioneering work to recent developments, we review how the interrogation of LHA cells and circuits is contributing to a mechanistic understanding of how the LHA coordinates complex behaviour.

  9. Typicality, graded membership, and vagueness.

    Science.gov (United States)

    Hampton, James A

    2007-05-01

    This paper addresses theoretical problems arising from the vagueness of language terms, and intuitions of the vagueness of the concepts to which they refer. It is argued that the central intuitions of prototype theory are sufficient to account for both typicality phenomena and psychological intuitions about degrees of membership in vaguely defined classes. The first section explains the importance of the relation between degrees of membership and typicality (or goodness of example) in conceptual categorization. The second and third section address arguments advanced by Osherson and Smith (1997), and Kamp and Partee (1995), that the two notions of degree of membership and typicality must relate to fundamentally different aspects of conceptual representations. A version of prototype theory-the Threshold Model-is proposed to counter these arguments and three possible solutions to the problems of logical selfcontradiction and tautology for vague categorizations are outlined. In the final section graded membership is related to the social construction of conceptual boundaries maintained through language use.

  10. Disrupted nodal and hub organization account for brain network abnormalities in Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Yuko Koshimori

    2016-11-01

    Full Text Available The recent application of graph theory to brain networks promises to shed light on complex diseases such as Parkinson’s disease. This study aimed to investigate functional changes in sensorimotor and cognitive networks in parkinsonian patients, with a focus on inter- and intra-connectivity organization in the disease-associated nodal and hub regions using the graph theoretical analyses. Resting-state functional MRI data of a total of 65 participants, including 23 healthy controls and 42 patients, were investigated in 120 nodes for local efficiency, betweenness centrality, and degree. Hub regions were identified in the healthy control and patient groups. We found nodal and hub changes in patients compared with healthy controls, including the right pre-supplementary motor area, left anterior insula, bilateral mid-insula, bilateral dorsolateral prefrontal cortex, and right caudate nucleus. In general, nodal regions within the sensorimotor network (i.e. right pre-supplementary motor area and right mid-insula displayed weakened connectivity, with the former node associated with more severe bradykinesia, and impaired integration with default mode network regions. The left mid-insula also lost its hub properties in patients. Within the executive networks, the left anterior insular cortex lost its hub properties in patients, while a new hub region was identified in the right caudate nucleus, paralleled by an increased level of inter- and intra-connectivity in the bilateral dorsolateral prefrontal cortex possibly representing compensatory mechanisms. These findings highlight the diffuse changes in nodal organization and regional hub disruption accounting for the distributed abnormalities across brain networks and the clinical manifestations of Parkinson’s disease.

  11. Effective Height Upper Bounds on Algebraic Tori

    CERN Document Server

    Habegger, Philipp

    2012-01-01

    The main emphasis will be on height upper bounds in the algebraic torus G^{n}_{m}. By height we will mean the absolute logarithmic Weil height. Section 3.2 contains a precise definition of this and other more general height functions. The first appendix gives a short overview of known results in the abelian case. The second appendix contains a few height bounds in Shimura varieties.

  12. Measuring Improvement when Using HUB Formats to Implement Floating-Point Systems under Round-to-Nearest

    OpenAIRE

    Hormigo, Javier; Julio, Villalba

    2016-01-01

    This paper analyzes the benefits of using HUB formats to implement floating-point arithmetic under round-tonearest mode from a quantitative point of view. Using HUB formats to represent numbers allows the removal of the rounding logic of arithmetic units, including sticky-bit computation. This is shown for floating-point adders, multipliers, and converters. Experimental analysis demonstrates that HUB formats and the corresponding arithmetic units maintain the same accurac...

  13. The application of design criteria for locating a hub configured supply chain for a restaurant cluster in the Stellenbosch area

    Directory of Open Access Journals (Sweden)

    Claudia B. Struwig

    2013-05-01

    Full Text Available Restaurants, in general, utilise numerous suppliers. Normally they deliver on different days in the week and at different times during the day, logistically not an optimum approach. Not only does the current practice cause frequent interruptions, but by segregating the food supply chain unnecessary traffic is generated. This article investigated the need for developing a third party supplier hub, the best positioning of that hub and the most economical routes to the customers. With the aim of providing non-franchised restaurants with the necessary leverage to become market leaders, the hub is planned to only service the restaurants within the vicinity of the Stellenbosch area. In such a hub-configured supply chain, the suppliers would be delivering to the proposed hub, from where once-off deliveries to all the restaurants may be made on days and/or times determined by them. In order to investigate the benefits of providing such a hub structure, a systematic implementation approach was used. The first step was to do market research in order to establish the need for such a hub. That is, the viability of the hub from a restaurant’s perspective was established. The next step entailed the investigation of the design criteria needed in determining a favourable hub location. Four possible hub locations were identified. The Clark and Wright’s savings algorithm was then used to determine the optimal hub location and the feasibility of the results was verified with the aid of a global positioning system (GPS device. The last steps followed involved the determination of an effective hub floor plan that may be utilised, possible products that can be supplied to the restaurants and the necessary assets needed to provide the hub’s service. Finally, by incorporating all these facets, a cost analysis was done to determine the hub’s profitability.

  14. Understanding farmers' preferences for artificial insemination services provided through dairy hubs.

    Science.gov (United States)

    Omondi, I A; Zander, K K; Bauer, S; Baltenweck, I

    2017-04-01

    Africa has a shortage of animal products but increasing demand because of population growth, urbanisation and changing consumer patterns. Attempts to boost livestock production through the use of breeding technologies such as artificial insemination (AI) have been failing in many countries because costs have escalated and success rates have been relatively low. One example is Kenya, a country with a relatively large number of cows and a dairy industry model relevant to neighbouring countries. There, an innovative dairy marketing approach (farmer-owned collective marketing systems called dairy hubs) has been implemented to enhance access to dairy markets and dairy-related services, including breeding services such as AI. So far, the rate of participation in these dairy hubs has been slow and mixed. In order to understand this phenomenon better and to inform dairy-related development activities by the Kenyan government, we investigated which characteristics of AI services, offered through the dairy hubs, farmers prefer. To do so, we applied a choice experiment (CE), a non-market valuation technique, which allowed us to identify farmers' preferences for desired characteristics should more dairy hubs be installed in the future. This is the first study to use a CE to evaluate breeding services in Kenya and the results can complement findings of studies of breeding objectives and selection criteria. The results of the CE reveal that dairy farmers prefer to have AI services offered rather than having no service. Farmers prefer AI services to be available at dairy hubs rather than provided by private agents not affiliated to the hubs, to have follow-up services for pregnancy detections, and to use sexed semen rather than conventional semen. Farmers would further like some flexibility in payment systems which include input credit, and are willing to share the costs of any AI repeats that may need to occur. These results provide evidence of a positive attitude to AI services

  15. TYPE PROJECTS HUB - AN INTERNATIONAL MODEL OF DEVELOPMENT OF THE ENTREPRENEURIAL ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Rozalia Nistor

    2014-06-01

    Full Text Available Impact Hub is a global network of local spaces and communities designed to facilitate sustainable impact through collaboration. Local Impact Hubs are autonomous companies that offer co-working spaces, programming, events platforms, and communities of individuals and organizations with ideas to build a better world. Hub was established in 2005 in London with the aim of creating a space dedicated to inspire, connect and enable people to achieve a sustainable entrepreneurial idea. The idea was simple: There are a lot of people with good ideas for a "better world". What seem to be missing are places to help these people to move from intent to action and to find like-minded for a greater impact. In Romania about four years ago, first opened in Bucharest office space hubs in Romania (for entrepreneurs in technology and business where teams from different companies could collaborate. The idea to open a hub in Bucharest focused on social innovation and entrepreneurship appeared some time ago in the context in which part of the team now has worked since 2010 at the initiation and growth of a community to support social entrepreneurship. In all this diversity, there is a common mission: “we can create if we put all our innovation capacity in the common goal to create a positive impact through our work?”

  16. nanoHUB.org: Experiences and Challenges in Software Sustainability for a Large Scientific Community

    Directory of Open Access Journals (Sweden)

    Lynn Zentner

    2014-07-01

    Full Text Available The science gateway nanoHUB.org, funded by the National Science Foundation (NSF, serves a large scientific community dedicated to research and education in nanotechnology with community-contributed simulation codes as well as a vast repository of other materials such as recorded presentations, teaching materials, and workshops and courses. Nearly 330,000 users annually access over 4400 items of content on nanoHUB, including 343 simulation tools. Arguably the largest nanotechnology facility in the world, nanoHUB has led the way not only in providing open access to scientific code in the nanotechnology community, but also in lowering barriers to the use of that code, by providing a platform where developers are able to easily and quickly deploy code written in a variety of languages with user-friendly graphical user interfaces and where users can run the latest versions of codes transparently on the grid or other powerful resources without ever having to download or update code. Being a leader in open access code deployment provides nanoHUB with opportunities and challenges as it meets the current and future needs of its community. This paper discusses the experiences of nanoHUB in addressing and adapting to the changing landscape of scientific software in ways that best serve its community and meet the needs of the largest portion of its user base.

  17. Encounter Probability of Individual Wave Height

    DEFF Research Database (Denmark)

    Liu, Z.; Burcharth, H. F.

    1998-01-01

    wave height corresponding to a certain exceedence probability within a structure lifetime (encounter probability), based on the statistical analysis of long-term extreme significant wave height. Then the design individual wave height is calculated as the expected maximum individual wave height...... associated with the design significant wave height, with the assumption that the individual wave heights follow the Rayleigh distribution. However, the exceedence probability of such a design individual wave height within the structure lifetime is unknown. The paper presents a method for the determination...... of the design individual wave height corresponding to an exceedence probability within the structure lifetime, given the long-term extreme significant wave height. The method can also be applied for estimation of the number of relatively large waves for fatigue analysis of constructions....

  18. Etymological study of Wuthering Heights

    Institute of Scientific and Technical Information of China (English)

    张倩; 张露

    2013-01-01

    In Wuthering Heights, the main characters and places have been delicately designed and cautiously named, which have their special implications based on the characters’identity, status and personalities or the features of the places. Therefore, through analyzing the implied meanings of the characters and place names in this novel, this essay illustrates that the author pur-posefully failed Heathcliff’s revenge. Meanwhile, the theme of this novel-Emily’s ultimate concern for the social inequality-is naturally exposed to the reader.

  19. Rapid height growth after liver transplantation in adulthood.

    Science.gov (United States)

    Szili, Balázs; Görög, Dénes; Gerlei, Zsuzsanna; Győri, Gabriella; Lakatos, Péter; Takács, István

    2016-08-01

    Glycogen storage disease Ib is a rare, inherited metabolic disorder caused by glucose-6-phosphatase translocase deficiency. Its main symptoms are hypoglycemia, hyperlipidemia, neutropenia, hepatomegaly, liver adenomas and short stature. The exact mechanism of short stature in this disease is unclear, the most feasible possibility is that it is caused by impairment of growth-hormone and insulin-like growth factor I axis. Here we report the case of a patient who showed typical symptoms of glycogen storage disease Ib since his infancy, his height being under 1 percentile since then. Later-developed hypothyroidism and hypogonadism have also contributed to his short stature. Hypothyroidism was treated but sexual steroid substitution was not started because of an increased risk of hepatic adenomas. Because he developed hepatic adenoma at the age of 23, he had to undergo orthotopic liver transplantation. At the time of the transplantation his height was 128cm. The transplantation was followed by rapid height growth; our patient's height reached 160.3cm 62months after transplantation. We observed that while his IGF-I level increased, his GH level remained unchanged. During the post-transplantation period we ensured adequate calcium and vitamin D supplementation, leaving hormonal substitution unchanged. According to our knowledge, this is the first report of a rapid height growth as big as 32cm, of an individual over the age of 20, not related to endocrine treatment but liver transplantation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. The influence of hubs in the structure of a neuronal network during an epileptic seizure

    Science.gov (United States)

    Rodrigues, Abner Cardoso; Cerdeira, Hilda A.; Machado, Birajara Soares

    2016-02-01

    In this work, we propose changes in the structure of a neuronal network with the intention to provoke strong synchronization to simulate episodes of epileptic seizure. Starting with a network of Izhikevich neurons we slowly increase the number of connections in selected nodes in a controlled way, to produce (or not) hubs. We study how these structures alter the synchronization on the spike firings interval, on individual neurons as well as on mean values, as a function of the concentration of connections for random and non-random (hubs) distribution. We also analyze how the post-ictal signal varies for the different distributions. We conclude that a network with hubs is more appropriate to represent an epileptic state.

  1. Identifying overlapping communities as well as hubs and outliers via nonnegative matrix factorization.

    Science.gov (United States)

    Cao, Xiaochun; Wang, Xiao; Jin, Di; Cao, Yixin; He, Dongxiao

    2013-10-21

    Community detection is important for understanding networks. Previous studies observed that communities are not necessarily disjoint and might overlap. It is also agreed that some outlier vertices participate in no community, and some hubs in a community might take more important roles than others. Each of these facts has been independently addressed in previous work. But there is no algorithm, to our knowledge, that can identify these three structures altogether. To overcome this limitation, we propose a novel model where vertices are measured by their centrality in communities, and define the identification of overlapping communities, hubs, and outliers as an optimization problem, calculated by nonnegative matrix factorization. We test this method on various real networks, and compare it with several competing algorithms. The experimental results not only demonstrate its ability of identifying overlapping communities, hubs, and outliers, but also validate its superior performance in terms of clustering quality.

  2. Synchronization and long-time memory in neural networks with inhibitory hubs and synaptic plasticity

    Science.gov (United States)

    Bertolotti, Elena; Burioni, Raffaella; di Volo, Matteo; Vezzani, Alessandro

    2017-01-01

    We investigate the dynamical role of inhibitory and highly connected nodes (hub) in synchronization and input processing of leaky-integrate-and-fire neural networks with short term synaptic plasticity. We take advantage of a heterogeneous mean-field approximation to encode the role of network structure and we tune the fraction of inhibitory neurons fI and their connectivity level to investigate the cooperation between hub features and inhibition. We show that, depending on fI, highly connected inhibitory nodes strongly drive the synchronization properties of the overall network through dynamical transitions from synchronous to asynchronous regimes. Furthermore, a metastable regime with long memory of external inputs emerges for a specific fraction of hub inhibitory neurons, underlining the role of inhibition and connectivity also for input processing in neural networks.

  3. Nonlinear Dynamic Analysis of Functionally Graded Timoshenko Beam fixed to a Rotating Hub

    Science.gov (United States)

    Panigrahi, B.; Pohit, G.

    2016-08-01

    The present work accounts centrifugal stiffening effect on the nonlinear vibration response of an FGM Timoshenko beam. Analysis is carried out for a cantilever beam fixed with a rotating hub. Material is assumed to have a gradation relation along the depth of the beam. Centrifugal force and axial displacement raised due to the rotating hub is incorporated in the strain energy equations. Subsequent to this, an iterative technique is employed to obtain amplitude dependent vibration response of a rotating Timoshenko beam while material follows a gradation relation along the beam depth. Main objective of the work is to obtain the effects of rotational speeds, hub radius, and different gradation relations on the linear as well as nonlinear frequencies and mode shapes.

  4. Effect of random and hub gene disruptions on environmental and mutational robustness in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Schneider Dominique

    2006-09-01

    Full Text Available Background Genome-wide profiling has allowed the regulatory interaction networks of many organisms to be visualised and the pattern of connections between genes to be studied. These networks are non-random, following a power-law distribution with a small number of well-connected 'hubs' and many genes with only one or a few connections. Theoretical work predicts that power-law networks display several unique properties. One of the most biologically interesting of these is an intrinsic robustness to disturbance such that removal of a random gene will have little effect on network function. Conversely, targeted removal of a hub gene is expected to have a large effect. Results We compared the response of Escherichia coli to environmental and mutational stress following disruption of random or hub genes. We found that disruption of random genes had less effect on robustness to environmental stress than did the targeted disruption of hub genes. In contrast, random disruption strains were slightly less robust to the effect of mutational stress than were hub disruption strains. When we compared the effect of each disruption on environmental and mutational stress, we found a negative relationship, such that strains that were more environmentally robust tended to be less robust to mutational stress. Conclusion Our results demonstrate that mutant strains of E. coli respond differently to stress, depending on whether random or hub genes are disrupted. This difference indicates that the power-law distribution of regulatory interactions has biological significance, making random disruptions less deleterious to organisms facing environmental stress. That E. coli can reduce the effect of environmental stress without reducing the phenotypic effect of additional mutations, indicates that robustness and evolvability need not be antagonistic.

  5. Characterization of protein hubs by inferring interacting motifs from protein interactions.

    Directory of Open Access Journals (Sweden)

    Ramon Aragues

    2007-09-01

    Full Text Available The characterization of protein interactions is essential for understanding biological systems. While genome-scale methods are available for identifying interacting proteins, they do not pinpoint the interacting motifs (e.g., a domain, sequence segments, a binding site, or a set of residues. Here, we develop and apply a method for delineating the interacting motifs of hub proteins (i.e., highly connected proteins. The method relies on the observation that proteins with common interaction partners tend to interact with these partners through a common interacting motif. The sole input for the method are binary protein interactions; neither sequence nor structure information is needed. The approach is evaluated by comparing the inferred interacting motifs with domain families defined for 368 proteins in the Structural Classification of Proteins (SCOP. The positive predictive value of the method for detecting proteins with common SCOP families is 75% at sensitivity of 10%. Most of the inferred interacting motifs were significantly associated with sequence patterns, which could be responsible for the common interactions. We find that yeast hubs with multiple interacting motifs are more likely to be essential than hubs with one or two interacting motifs, thus rationalizing the previously observed correlation between essentiality and the number of interacting partners of a protein. We also find that yeast hubs with multiple interacting motifs evolve slower than the average protein, contrary to the hubs with one or two interacting motifs. The proposed method will help us discover unknown interacting motifs and provide biological insights about protein hubs and their roles in interaction networks.

  6. Hub vortex instability and wake dynamics in axial flow wind turbines

    Science.gov (United States)

    Foti, Daniel; Howard, Kevin; Yang, Xiaolei; Guala, Michele; Sotiropoulos, Fotis

    2014-11-01

    The near wake region of an axial flow wind turbine has two distinct shear layers: an outer tip vortex shear layer, which rotates in the same direction as the rotor, and an inner counter-rotating hub vortex shear layer. Recent simulations (Kang et al., J. Fluid Mech. 744, 376 (2014)), corroborated with experiments (Chamorro et al., J. Fluid Mech. 716, 658 (2013)), showed that the hub vortex can undergo spiral vortex breakdown immediately downstream of the turbine. The precessing hub vortex core intercepts and interacts with the tip vortex shear layer causing the large-scale wake meandering motions in the far wake to intensify. These results were obtained for an axial flow hydrokinetic turbine in a turbulent open channel flow. Here we integrate high-resolution LES with experiments to show that a hub vortex instability also occurs in the near wake of a wind turbine in a wind tunnel. We show that the interactions of the hub vortex with the outer flow have significant effects on the wake meandering amplitude and frequency. Our results reinforce the conclusions of Kang et al. (2014) that the hub vortex must be included in wake models to simulate wake interactions at the power plant scale and optimize turbine siting for realistic terrain and wind conditions. This work was supported by DOE (DE-EE0002980, DE-EE0005482 and DE-AC04-94AL85000), the NSF (IIP-1318201), the IREE early career award (UMN) and NSF CAREER: Geophysical Flow Control (CBET-1351303). Computational resources were provided by MSI.

  7. The new forging process of a wheel hub drop forging

    OpenAIRE

    A. Gontarz

    2006-01-01

    Purpose: The main purpose of the research was working out a new flashless forming process of wheel hubforging in three-slide forging press (TSFP). It was assumed that the new process would be more effective thanthe forging processes applied in typical forging machines.Design/methodology/approach: The designing of the new process was based on the simulation by finiteelement method with the assumption of 3D state of strain. Calculations were made mainly for the analysis of thematerial flow kine...

  8. Hub vortex instability within wind turbine wakes: Effects of wind turbulence, loading conditions, and blade aerodynamics

    Science.gov (United States)

    Ashton, Ryan; Viola, Francesco; Camarri, Simone; Gallaire, Francois; Iungo, Giacomo Valerio

    2016-11-01

    The near wake of wind turbines is characterized by the presence of the hub vortex, which is a coherent vorticity structure generated from the interaction between the root vortices and the boundary layer evolving over the turbine nacelle. By moving downstream, the hub vortex undergoes an instability with growth rate, azimuthal and axial wavenumbers determined by the characteristics of the incoming wind and turbine aerodynamics. Thus, a large variability of the hub vortex instability is expected for wind energy applications with consequent effects on wake downstream evolution, wake interactions within a wind farm, power production, and fatigue loads on turbines invested by wakes generated upstream. In order to predict characteristics of the hub vortex instability for different operating conditions, linear stability analysis is carried out by considering different statistics of the incoming wind turbulence, thrust coefficient, tip speed ratio, and blade lift distribution of a wind turbine. Axial and azimuthal wake velocity fields are modeled through Carton-McWilliams velocity profiles by mimicking the presence of the hub vortex, helicoidal tip vortices, and matching the wind turbine thrust coefficient predicted through the actuator disk model. The linear stability analysis shows that hub vortex instability is strongly affected by the wind turbine loading conditions, and specifically it is promoted by a larger thrust coefficient. A higher load of the wind turbines produces an enhanced axial velocity deficit and, in turn, higher shear in the radial direction of the streamwise velocity. The axial velocity shear within the turbine wake is also the main physical mechanism promoting the hub vortex instability when varying the lift distribution over the blade span for a specific loading condition. Cases with a larger velocity deficit in proximity of the wake center and less aerodynamic load towards the blade tip result to be more unstable. Moreover, wake swirl promotes hub

  9. Japanese Forwarders’ Local Import Hub in Asia: 3PL Power and Environmental Improvement

    Directory of Open Access Journals (Sweden)

    Kunio MIYASHITA

    2015-09-01

    Full Text Available The purpose of this paper is to demonstrate by an econometric method which countries or regions in Asia are superior import hubs for Japan based on two axes, the third party logistics (3PL business power of Japanese local forwarders and the logistical environment catch-up speed of these countries. According to the estimated results, this simple model can explain the structural changes in China's logistics based on its WTO accession and can develop Japanese forwarders’ stable import hub ranking by suggesting total optimization in the East Asian NIES (newly industrial economies and the ASEAN (Association of Southeast Asian Countries districts by Japanese forwarders.

  10. Single wheel hub motor failures and their impact on vehicle and driver behaviour

    Science.gov (United States)

    Wanner, Daniel; Kreußlein, Maria; Augusto, Bruno; Drugge, Lars; Stensson Trigell, Annika

    2016-10-01

    This research work studies the impact of single wheel hub motor failures on the dynamic behaviour of electric vehicles and the corresponding driver reactions. An experimental study in a moving-base driving simulator is conducted to analyse the influence of single wheel hub motor failures for motorway speeds. Driver reaction times are derived from the measured data and discussed in their experimental context. The failure is rated objectively on the dynamic behaviour of the vehicle and compared to the subjective evaluation. Findings indicate that critical traffic situations impairing traffic safety can occur for motorway speeds. Clear counteractions by the drivers had to be taken.

  11. Transfer Scheme Evaluation Model for a Transportation Hub based on Vectorial Angle Cosine

    Directory of Open Access Journals (Sweden)

    Li-Ya Yao

    2014-07-01

    Full Text Available As the most important node in public transport network, efficiency of a transport hub determines the entire efficiency of the whole transport network. In order to put forward effective transfer schemes, a comprehensive evaluation index system of urban transport hubs’ transfer efficiency was built, evaluation indexes were quantified, and an evaluation model of a multi-objective decision hub transfer scheme was established based on vectorial angle cosine. Qualitative and quantitative analysis on factors affecting transfer efficiency is conducted, which discusses the passenger satisfaction, transfer coordination, transfer efficiency, smoothness, economy, etc. Thus, a new solution to transfer scheme utilization was proposed.

  12. Virtual Campus Hub: A single sign-on system for cross-border collaboration

    DEFF Research Database (Denmark)

    Badger, Merete; Vercoulen, F.; Monaco, L.

    2013-01-01

    the applications used there. The objective of Virtual Campus Hub is to use state-of-the-art European e-Infrastructures (Géant) in combination with federated authentication to establish a single sign-on system between universities. A pilot environment, which links applications from the four partner universities...... to European e-Infrastructures relies upon the National Research and Education Networks (NRENs) which are not geared towards commercial enterprises at present. A range of applications for online teaching and collaboration has been developed as part of the Virtual Campus Hub project. These include remote...

  13. Hub-enhanced noise-sustained synchronization of an externally forced FitzHugh-Nagumo ring

    Science.gov (United States)

    Sánchez, Alejandro D.; Izús, Gonzalo G.; dell'Erba, Matías G.; Deza, Roberto R.

    2017-02-01

    A ring of FitzHugh-Nagumo units with antiphase coupling between their activator fields and submitted to a adiabatic harmonic subthreshold signal, is in turn globally coupled in electrical mode with the activator field of a hub. Noise sustained synchronization of neural activity with the signal is numerically observed, and theoretically characterized. The different dynamical regimes are elucidated using the concept of nonequilibrium potential, and the hub is found to promote network synchronization. The minimum noise intensities triggering the activation and synchronization processes are estimated in the framework of a three-neuron model.

  14. The Design Pattern: Hub of Enterprise Application Integration%一个企业应用集成的设计模式:Hub

    Institute of Scientific and Technical Information of China (English)

    董云卫; 李伟宏; 郝克刚

    2003-01-01

    The Enterprise Application Integration (EAI) is a challenge of modern enterprise. How much effect of information system in enterprise business implement process that depends on the degree of inner function and information integration of formation system. The choice of EAI methods not only affects the investment of constructing information system and protecting /using old system, but also determines the efficiency of new system. This paper presents a design pattern, named Hub method, from the view of application integration, which adopts the idea in heterogeneous circumstance focusing on interface encapsulating about controlling information exchange and workflow handling. It also gives an implement method and a framework of the Hub in this paper, which is applied on business process management. And a good performance is achieved in controlling information exchange and workflow handling among enterprise applications. It not only improves system integration capability, stich as expansibility, flexibility, and opening through the method of the Hub, but also takes a great advance in soft reuse during software designing and implementing.

  15. Counting Young Tableaux of Bounded Height

    Science.gov (United States)

    Bergeron, Francois; Gascon, Francis

    2000-03-01

    We show that formulas of Gessel, for the generating functions for Young standard tableaux of height bounded by k (see [2]), satisfy linear differential equations, with polynomial coefficients, equivalent to P-recurrences conjectured by Favreau, Krob and the first author (see [1]) for the number of bounded height tableaux and pairs of bounded height tableaux.

  16. Height and Gradient from Shading

    Science.gov (United States)

    1989-05-01

    to instability32 . The Gauss- Seidel method typically can be sped up in this fashion by choosing a value for a close to two-the scheme becomes...unstable for a > 2. Unfortunately the Gauss- Seidel method does not lend itself to parallel implementation. The Jacobi method is suited for parallel...Gauss- Seidel method , which accounts for its stability. This also suggests a modification of the Jacobi method, where the parallel update of the cells is

  17. 76 FR 10328 - Grant of Authority for Subzone Status; Vestas Nacelles America, Inc. (Wind Turbine Nacelles, Hubs...

    Science.gov (United States)

    2011-02-24

    ... manufacturing and warehousing of wind turbine nacelles, hubs, blades and towers at the Vestas Nacelles America... Foreign-Trade Zones Board Grant of Authority for Subzone Status; Vestas Nacelles America, Inc. (Wind Turbine Nacelles, Hubs, Blades and Towers), Brighton, Denver, Pueblo, and Windsor, CO Pursuant to...

  18. 75 FR 76003 - Tricor Ten Section Hub LLC; Notice of Availability of the Environmental Assessment for the...

    Science.gov (United States)

    2010-12-07

    ... Energy Regulatory Commission Tricor Ten Section Hub LLC; Notice of Availability of the Environmental Assessment for the Proposed Ten Section Gas Storage Project November 29, 2010. The staff of the Federal... Ten Section Gas Storage Project, in Kern County, California, proposed by Tricor Ten Section Hub...

  19. USDA Midwest and Northern Forests Regional Climate Hub: Assessment of climate change vulnerability and adaptation and mitigation strategies

    Science.gov (United States)

    The Midwest Regional Climate Hub covers the States of Illinois, Indiana, Iowa, Michigan, Minnesota, Missouri, Ohio, and Wisconsin and represents one of the most extensive and intensive agricultural systems in the world. The Northern Forests Climate Sub Hub shares this footprint and represents people...

  20. Estimating vehicle height using homographic projections

    Science.gov (United States)

    Cunningham, Mark F; Fabris, Lorenzo; Gee, Timothy F; Ghebretati, Jr., Frezghi H; Goddard, James S; Karnowski, Thomas P; Ziock, Klaus-peter

    2013-07-16

    Multiple homography transformations corresponding to different heights are generated in the field of view. A group of salient points within a common estimated height range is identified in a time series of video images of a moving object. Inter-salient point distances are measured for the group of salient points under the multiple homography transformations corresponding to the different heights. Variations in the inter-salient point distances under the multiple homography transformations are compared. The height of the group of salient points is estimated to be the height corresponding to the homography transformation that minimizes the variations.

  1. Global Unification Problem of the Height System

    Directory of Open Access Journals (Sweden)

    XU Houze

    2017-08-01

    Full Text Available Some fundamental problems on the establishment of the global unified height system, including the geometry and gravity definition of the normal height, the global unification of the regional height systems obtained from leveling measurements, and the determination of geoid potential W0 are discussed. The main conclusions are summarized:①The definition of normal height in the sense of geometry leveling and gravity theory is different, so that h-ζ≠HL, here h, ζ and HL are geodetic height, height anomaly and levelling height respectively. Instead of it, we found HL=h-ζ+∂γ/∂hζH, in the mountain area, the last correction term have to be added. ②Based on the merging of GNSS/gravity/regional leveling, the regional leveling height can be transformed into a global relative unified height system, however the value of geoid potential W0 is still needed in order to establish an absolute height system. ③W0 can be determinated from the modern geodetic techniques with a certain accuracy, but it is time variable, so that people may only define a global absolute unified height system in a fixed epoch.

  2. SensorWeb Hub infrastructure for open access to scientific research data

    Science.gov (United States)

    de Filippis, Tiziana; Rocchi, Leandro; Rapisardi, Elena

    2015-04-01

    The sharing of research data is a new challenge for the scientific community that may benefit from a large amount of information to solve environmental issues and sustainability in agriculture and urban contexts. Prerequisites for this challenge is the development of an infrastructure that ensure access, management and preservation of data, technical support for a coordinated and harmonious management of data that, in the framework of Open Data Policies, should encourages the reuse and the collaboration. The neogeography and the citizen as sensors approach, highlight that new data sources need a new set of tools and practices so to collect, validate, categorize, and use / access these "crowdsourced" data, that integrate the data sets produced in the scientific field, thus "feeding" the overall available data for analysis and research. When the scientific community embraces the dimension of collaboration and sharing, access and re-use, in order to accept the open innovation approach, it should redesign and reshape the processes of data management: the challenges of technological and cultural innovation, enabled by web 2.0 technologies, bring to the scenario where the sharing of structured and interoperable data will constitute the unavoidable building block to set up a new paradigm of scientific research. In this perspective the Institute of Biometeorology, CNR, whose aim is contributing to sharing and development of research data, has developed the "SensorWebHub" (SWH) infrastructure to support the scientific activities carried out in several research projects at national and international level. It is designed to manage both mobile and fixed open source meteorological and environmental sensors, in order to integrate the existing agro-meteorological and urban monitoring networks. The proposed architecture uses open source tools to ensure sustainability in the development and deployment of web applications with geographic features and custom analysis, as requested

  3. Role of governance in creating a commodity hub: A comparative analysis

    Directory of Open Access Journals (Sweden)

    M.P. Haris

    2016-10-01

    Full Text Available The body of work on natural gas hubs has been expanding rapidly in recent years, with most of the current work examining the creation of gas hubs focusing on either the European experience or the North American experience. In this paper, we adopt a different perspective and place the focus on experience of hub building from other international commodities. We analyse three commodities - crude oil, iron ore and coal, and draw experience on the role of governance in development of hub based prices. In particular, we propose that the role of governance is different at different stages of the pricing transition to market based pricing. Governance could play an important role at the initial stage, building the relevant soft and physical infrastructure which facilitates the reaping of first mover advantage. As the market develops, private sector players may prefer less involvement of governance, which may distort markets. With market stabilization, governance should be focused on maintaining stable rules and regulation for private sector development, as well as monitoring for further changes in global trends. To facilitate the building of a benchmark price, the public sector should adopt a long-term and overarching view on industry growth.

  4. Hub-and-Spoke or else? Free trade agreements in the 'enlarged' European Union

    Directory of Open Access Journals (Sweden)

    Roberta De Santis

    2005-12-01

    Full Text Available The object of this paper is to estimate if and how the Central European Free Trade Agreement (CEFTA and the Baltic Free Trade Agreement (BFTA exerted a significant impact on intra-European trade, effectively reducing the influence of the European Association Agreements (EAs in shaping the European trade structure as a hub-and-spoke system - with the EU15 being the hub and the CEECs the spoke. This paper analyses bilateral trade flows between eight CEECs and EU-23. We estimate a gravity equation using a system GMM dynamic panel data approach. Results support the assumptions that gravity forces and "persistence effects" matter. With respect to the effect of free trade agreements, evidence is found that Free trade agreements between CEECs matter: There is evidence that the presence of intra-periphery agreements helped expand intra-periphery trade and limited the emergence of a "hub-and-spoke" relationship between CEECs and EU. This results have important policy implications for the trade strategy of "future" EU members of the Southeastern European Countries as well as of the Southern Mediterranean Countries. According to the empirical results, these countries should move towards a regional free-trade area as exemplified by the CEFTA and the BFTA to avoid "hub-and-spoke" effects.

  5. Unveiling Exception Handling Bug Hazards in Android Based on GitHub and Google Code Issues

    NARCIS (Netherlands)

    Coelho, R.; Almeida, L.; Gousios, G.; Van Deursen, A.

    2015-01-01

    This paper reports on a study mining the exception stack traces included in 159,048 issues reported on Android projects hosted in GitHub (482 projects) and Google Code (157 projects). The goal of this study is to investigate whether stack trace information can reveal bug hazards related to exception

  6. Towards collaborative, intermodal hub networks. A case study in the fast moving consumer goods market

    NARCIS (Netherlands)

    Groothedde, B.; Ruijgrok, C.; Tavasszy, L.

    2005-01-01

    Collaborative hub networks can provide an answer to the need to decrease logistics cost and maintain logistics service levels by shifting consolidated flows to modes that are better suited for handling large volumes (rail, barge, coastal shipping), so economies of scale can be obtained. This necessi

  7. Hub and shroud fillets influence on the radial compressor stage efficiency

    Directory of Open Access Journals (Sweden)

    Syka Tomáš

    2015-01-01

    Full Text Available Article describes numerical simulations of an air flow in the radial compressor stage in the NUMECA CFD software. During the tasks evaluating the stepped and straight impeller seals and hub and shroud fillets influence on working characteristics and flow field was observed. Also the CFD results comparison with results from the empiric design tool and the measurement is described.

  8. An Optimization of the Hub-and-Spoke Distribution Network in United States European Command

    Science.gov (United States)

    2002-03-01

    9 Vehicle Routing Problem ......................................................................................... 11...system. These range from direct delivery to a fully developed hub-and-spoke system. These models all include some variation of the vehicle routing problem , facility...assets. Vehicle Routing Problem Vehicle Routing Problems (VRPs) are based on the classic Traveling Salesman Problem (TSP). The TSP is

  9. Positioning as Regional Hub of Higher Education: Changing Governance and Regulatory Reforms in Singapore and Malaysia

    Science.gov (United States)

    Mok, Ka Ho

    2008-01-01

    With strong intention to enhance the global competitiveness of their university systems, the Singapore and Malaysia governments have made attempts to develop their societies into regional hubs of education. Specifically, they have invited foreign universities to set up their campuses to offer academic programs or to establish private institutions…

  10. Positioning as Regional Hub of Higher Education: Changing Governance and Regulatory Reforms in Singapore and Malaysia

    Science.gov (United States)

    Mok, Ka Ho

    2008-01-01

    With strong intention to enhance the global competitiveness of their university systems, the Singapore and Malaysia governments have made attempts to develop their societies into regional hubs of education. Specifically, they have invited foreign universities to set up their campuses to offer academic programs or to establish private institutions…

  11. Evaluating Hub and Spoke models of practice learning in Scotland, UK: a multiple case study approach.

    Science.gov (United States)

    Roxburgh, Michelle; Conlon, Margaret; Banks, Debbie

    2012-10-01

    Most of UK students' practice learning experience is based on a rotational placement model which often leads to students lacking confidence and feeling anxious about the complexities of the care environment. To evaluate the impact of Hub and Spoke model(s) of clinical practice placement across geographically diverse locations, with a particular focus on enhancing the student practice learning experience. Multiple case study design. Comprised undergraduate student nurses from Adult, Learning Disability and Mental Health programmes from 3 Scottish Schools of Nursing. A mixed methods approach which included quantitative and qualitative date tools. All three Hub and Spoke models shared two broad findings: 1) In the three Hub and Spoke models detailed in this paper, there is a continuum of student led learning which supports the process with opportunities for individual students to be positively innovative and creative in their learning approaches. Depth of learning was achieved in two ways; a) the method in which Hub placements are organised, managed and structured and, b) the depth of empathy and sensitivity to the individual at the centre of the care. 2) Placement capacity is increased: The classification of placements is reviewed to produce broader categories, Engagement of mentors/enhanced student/mentor relationship. Practice Learning must be seen as an academic endeavour that promotes deep, meaningful, person-centred learning rather than superficial, compartmentalised placement-centred learning. Copyright © 2012 Elsevier Ltd. All rights reserved.

  12. Dynamic network participation of functional connectivity hubs assessed by resting-state fMRI

    Science.gov (United States)

    Schaefer, Alexander; Margulies, Daniel S.; Lohmann, Gabriele; Gorgolewski, Krzysztof J.; Smallwood, Jonathan; Kiebel, Stefan J.; Villringer, Arno

    2014-01-01

    Network studies of large-scale brain connectivity have demonstrated that highly connected areas, or “hubs,” are a key feature of human functional and structural brain organization. We use resting-state functional MRI data and connectivity clustering to identify multi-network hubs and show that while hubs can belong to multiple networks their degree of integration into these different networks varies dynamically over time. The extent of the network variation was related to the connectedness of the hub. In addition, we found that these network dynamics were inversely related to positive self-generated thoughts reported by individuals and were further decreased with older age. Moreover, the left caudate varied its degree of participation between a default mode subnetwork and a limbic network. This variation was predictive of individual differences in the reports of past-related thoughts. These results support an association between ongoing thought processes and network dynamics and offer a new approach to investigate the brain dynamics underlying mental experience. PMID:24860458

  13. Fleet deployment, network design and hub location of liner shipping companies

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Pisinger, David

    2011-01-01

    A mixed integer linear programming formulation is proposed for the simultaneous design of network and fleet deployment of a deep-sea liner service provider. The underlying network design problem is based on a 4-index (5-index by considering capacity type) formulation of the hub location problem...

  14. Towards collaborative, intermodal hub networks. A case study in the fast moving consumer goods market

    NARCIS (Netherlands)

    Groothedde, B.; Ruijgrok, C.; Tavasszy, L.

    2005-01-01

    Collaborative hub networks can provide an answer to the need to decrease logistics cost and maintain logistics service levels by shifting consolidated flows to modes that are better suited for handling large volumes (rail, barge, coastal shipping), so economies of scale can be obtained. This

  15. Perceptions of Quality Life in Hamilton's Neighbourhood Hubs: A Qualitative Analysis

    Science.gov (United States)

    Eby, Jeanette; Kitchen, Peter; Williams, Allison

    2012-01-01

    This paper examines perceptions of quality of life in Hamilton, Ontario, Canada from the perspective of residents and key community stakeholders. A series of eight focus groups were conducted. Six sessions were held with residents of neighbourhood "hubs", areas characterized by high levels of poverty. The following themes were highlighted as…

  16. A note on hierarchical hubbing for a generalization of the VPN problem

    NARCIS (Netherlands)

    Olver, N.K.

    2014-01-01

    Robust network design refers to a class of optimization problems that occur when designing networks to efficiently handle variable demands. The notion of "hierarchical hubbing" was introduced (in the narrow context of a specific robust network design question), by Olver and Shepherd [2010]. Hierarch

  17. National Geothermal Data System Hub Deployment Timeline (Appendix E-1-d)

    Energy Technology Data Exchange (ETDEWEB)

    Caudill, Christy [Executive Office of the State of Arizona (Arizona Geological Survey)

    2015-12-20

    Excel spreadsheet describing activity, spending, and development for the four data hubs (Arizona Geoloical Survey, Kentucky Geological Survey, Illinois Geological Survey, and Nevada Bureau of Mines and Geology) serving data for the National Geothermal Data System under the State Contributions to the National Geothermal Data System Project.

  18. Brief Report: The Negev Hospital-University-Based (HUB) Autism Database

    Science.gov (United States)

    Meiri, Gal; Dinstein, Ilan; Michaelowski, Analya; Flusser, Hagit; Ilan, Michal; Faroy, Michal; Bar-Sinai, Asif; Manelis, Liora; Stolowicz, Dana; Yosef, Lili Lea; Davidovitch, Nadav; Golan, Hava; Arbelle, Shosh; Menashe, Idan

    2017-01-01

    Elucidating the heterogeneous etiologies of autism will require investment in comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established a hospital-university-based (HUB) database of autism which incorporates prospective and retrospective data from a large and ethnically diverse…

  19. Perceptions of Quality Life in Hamilton's Neighbourhood Hubs: A Qualitative Analysis

    Science.gov (United States)

    Eby, Jeanette; Kitchen, Peter; Williams, Allison

    2012-01-01

    This paper examines perceptions of quality of life in Hamilton, Ontario, Canada from the perspective of residents and key community stakeholders. A series of eight focus groups were conducted. Six sessions were held with residents of neighbourhood "hubs", areas characterized by high levels of poverty. The following themes were…

  20. Fleet deployment, network design and hub location of liner shipping companies

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Pisinger, David

    2011-01-01

    A mixed integer linear programming formulation is proposed for the simultaneous design of network and fleet deployment of a deep-sea liner service provider. The underlying network design problem is based on a 4-index (5-index by considering capacity type) formulation of the hub location problem...

  1. Dubai, Aiming to Be an Academic Hub, Strikes a Deal with Michigan State

    Science.gov (United States)

    Krieger, Zvika

    2007-01-01

    Dubai has long competed with its wealthy Persian Gulf neighbors to become a regional hub of higher education. Yet its Knowledge Village, a collection of nearly 20 foreign-university campuses and local educational institutes, has been overshadowed by Qatar's Education City, which is home to the branch campuses of a number of high-profile American…

  2. PERSEUS-HUB: Interactive and Collective Exploration of Large-Scale Graphs

    Directory of Open Access Journals (Sweden)

    Di Jin

    2017-07-01

    Full Text Available Graphs emerge naturally in many domains, such as social science, neuroscience, transportation engineering, and more. In many cases, such graphs have millions or billions of nodes and edges, and their sizes increase daily at a fast pace. How can researchers from various domains explore large graphs interactively and efficiently to find out what is ‘important’? How can multiple researchers explore a new graph dataset collectively and “help” each other with their findings? In this article, we present Perseus-Hub, a large-scale graph mining tool that computes a set of graph properties in a distributed manner, performs ensemble, multi-view anomaly detection to highlight regions that are worth investigating, and provides users with uncluttered visualization and easy interaction with complex graph statistics. Perseus-Hub uses a Spark cluster to calculate various statistics of large-scale graphs efficiently, and aggregates the results in a summary on the master node to support interactive user exploration. In Perseus-Hub, the visualized distributions of graph statistics provide preliminary analysis to understand a graph. To perform a deeper analysis, users with little prior knowledge can leverage patterns (e.g., spikes in the power-law degree distribution marked by other users or experts. Moreover, Perseus-Hub guides users to regions of interest by highlighting anomalous nodes and helps users establish a more comprehensive understanding about the graph at hand. We demonstrate our system through the case study on real, large-scale networks.

  3. Unveiling Exception Handling Bug Hazards in Android Based on GitHub and Google Code Issues

    NARCIS (Netherlands)

    Coelho, R.; Almeida, L.; Gousios, G.; Van Deursen, A.

    2015-01-01

    This paper reports on a study mining the exception stack traces included in 159,048 issues reported on Android projects hosted in GitHub (482 projects) and Google Code (157 projects). The goal of this study is to investigate whether stack trace information can reveal bug hazards related to exception

  4. Nonlinear dynamics and synchronisation of pendula attached to a rotating hub

    Science.gov (United States)

    Warminski, J.; Szmit, Z.; Latalski, J.

    2014-04-01

    A model of a nonlinear system composed of a hub with attached two pendula rotating in a horizontal plane is studied in the paper. Each single pendulum, treated as a stiff and massless rod with a lumped mass, is connected to the hub by a flapping hinge. Nonlinear stiffness and viscous damping of the hinge is taken into consideration. The system is excited by an external torque generated by a DC motor which is considered as an ideal system with torque given by a harmonic function. For small oscillations the problem is linearised and then solved analytically. An influence of the structural parameters like mass of the hub and pendula length on natural end excited vibrations is presented. Large oscillations are studied by a continuation technique, directly from the original Ordinary Differential Equations of motion (ODE). The complete synchronisation, phase synchronisation, bifurcations and transition through resonances are analysed considering the influence of the mass of the hub. The existence of chaotic oscillations of the system and paths leading to chaos are demonstrated as well.

  5. Development of passive-controlled HUB (teetered brake & damper mechanism) of horizontal axis wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, Yukimaru; Kamada, Yasunari; Maeda, Takao [Mie Univ. (Japan)

    1997-12-31

    For the purpose of the improvement of reliability of the Mega-Watt wind turbine, this paper indicates the development of an original mechanism for the passive-controlled hub, which has the effects of braking and damping on aerodynamic forces. This mechanism is useful for variable speed control of the large wind turbine. The passive-controlled hub is the combination of two mechanisms. One is the passive-teetered and damping mechanism, and the other is the passive-variable-pitch mechanism. These mechanism are carried out by the combination of the teetering and feathering motions. When the wind speed exceeds the rated wind speed, the blade is passively teetered in a downwind direction and, simultaneously, a feathering mechanism, which is linked to the teetering mechanism through a connecting rods, is activated. Testing of the model horizontal axis wind turbine in a wind tunnel showed that the passive-controlled hub mechanism can suppress the over-rotational speed of the rotor. By the application of the passive-controlled hub mechanism, the maximum rotor speed is reduced to about 60%.

  6. Strategic analysis on establishing a natural gas trading hub in China

    Directory of Open Access Journals (Sweden)

    Xiaoguang Tong

    2014-12-01

    Full Text Available Since 2010, the LNG importing price premium in the Asia–Pacific markets has become increasingly high, generating great effects on the economic development in China. In addition, the natural gas dependence degree is expanding continuously, making it extremely urgent to establish a natural gas trading hub in China, with the aim to ensure national energy security, to gain the pricing power, and to build the regional benchmark prices. Through a comparative analysis of internal strength/weakness and external competitiveness, we concluded that with intensively-issued supporting policies on the natural gas sector, the initiation of spot and futures markets, the rapid growth of gas production and highly-improved infrastructures, as well as Shanghai's advantageous location, China has more advantages in establishing an Asian Natural Gas Trading Hub than other counties like Singapore, Japan and Malaysia. Moreover, based on the SWOT (strength, weakness, opportunity and threat and the marketization process analysis, the following strategies were presented: to impel the establishment of a natural gas trading hub depending on the gas supply condition, to follow the policies to complete the gas storage system, to form regional communities by taking comparative advantages, and to reinforce the marketization reform and regulation system establishment with foreign experiences for reference. This study rationalized the necessity and practicality of establishing a natural gas trading hub in China and will help China make a proper decision and find a periodical strategic path in this sector.

  7. Altered connectivity pattern of hubs in default-mode network with Alzheimer's disease: an Granger causality modeling approach.

    Directory of Open Access Journals (Sweden)

    Xiaoyan Miao

    Full Text Available BACKGROUND: Evidences from normal subjects suggest that the default-mode network (DMN has posterior cingulate cortex (PCC, medial prefrontal cortex (MPFC and inferior parietal cortex (IPC as its hubs; meanwhile, these DMN nodes are often found to be abnormally recruited in Alzheimer's disease (AD patients. The issues on how these hubs interact to each other, with the rest nodes of the DMN and the altered pattern of hubs with respect to AD, are still on going discussion for eventual final clarification. PRINCIPAL FINDINGS: To address these issues, we investigated the causal influences between any pair of nodes within the DMN using Granger causality analysis and graph-theoretic methods on resting-state fMRI data of 12 young subjects, 16 old normal controls and 15 AD patients respectively. We found that: (1 PCC/MPFC/IPC, especially the PCC, showed the widest and distinctive causal effects on the DMN dynamics in young group; (2 the pattern of DMN hubs was abnormal in AD patients compared to old control: MPFC and IPC had obvious causal interaction disruption with other nodes; the PCC showed outstanding performance for it was the only region having causal relation with all other nodes significantly; (3 the altered relation between hubs and other DMN nodes held potential as a noninvasive biomarker of AD. CONCLUSIONS: Our study, to the best of our knowledge, is the first to support the hub configuration of the DMN from the perspective of causal relationship, and reveal abnormal pattern of the DMN hubs in AD. Findings from young subjects provide additional evidence for the role of PCC/MPFC/IPC acting as hubs in the DMN. Compared to old control, MPFC and IPC lost their roles as hubs owing to the obvious causal interaction disruption, and PCC was preserved as the only hub showing significant causal relations with all other nodes.

  8. Coffee Shops, Classrooms and Conversations: public engagement and outreach in a large interdisciplinary research Hub

    Science.gov (United States)

    Holden, Jennifer A.

    2014-05-01

    Public engagement and outreach activities are increasingly using specialist staff for co-ordination, training and support for researchers, they are also becoming expected for large investments. Here, the experience of public engagement and outreach a large, interdisciplinary Research Hub is described. dot.rural, based at the University of Aberdeen UK, is a £11.8 million Research Councils UK Rural Digital Economy Hub, funded as part of the RCUK Digital Economy Theme (2009-2015). Digital Economy research aims to realise the transformational impact of digital technologies on aspects of the environment, community life, cultural experiences, future society, and the economy. The dot.rural Hub involves 92 researchers from 12 different disciplines, including Geography, Hydrology and Ecology. Public Engagement and Outreach is embedded in the dot.rural Digital Economy Hub via an Outreach Officer. Alongside this position, public engagement and outreach activities are compulsory part of PhD student contracts. Public Engagement and Outreach activities at the dot.rural Hub involve individuals and groups in both formal and informal settings organised by dot.rural and other organisations. Activities in the realms of Education, Public Engagement, Traditional and Social Media are determined by a set of Underlying Principles designed for the Hub by the Outreach Officer. The underlying Engagement and Outreach principles match funding agency requirements and expectations alongside researcher demands and the user-led nature of Digital Economy Research. All activities include researchers alongside the Outreach Officer are research informed and embedded into specific projects that form the Hub. Successful public engagement activities have included participation in Café Scientifique series, workshops in primary and secondary schools, and online activities such as I'm a Scientist Get Me Out of Here. From how to engage 8 year olds with making hydrographs more understandable to members of

  9. Declining functional connectivity and changing hub locations in Alzheimer's disease: an EEG study.

    Science.gov (United States)

    Engels, Marjolein M A; Stam, Cornelis J; van der Flier, Wiesje M; Scheltens, Philip; de Waal, Hanneke; van Straaten, Elisabeth C W

    2015-08-20

    EEG studies have shown that patients with Alzheimer's disease (AD) have weaker functional connectivity than controls, especially in higher frequency bands. Furthermore, active regions seem more prone to AD pathology. How functional connectivity is affected in AD subgroups of disease severity and how network hubs (highly connected brain areas) change is not known. We compared AD patients with different disease severity and controls in terms of functional connections, hub strength and hub location. We studied routine 21-channel resting-state electroencephalography (EEG) of 318 AD patients (divided into tertiles based on disease severity: mild, moderate and severe AD) and 133 age-matched controls. Functional connectivity between EEG channels was estimated with the Phase Lag Index (PLI). From the PLI-based connectivity matrix, the minimum spanning tree (MST) was derived. For each node (EEG channel) in the MST, the betweenness centrality (BC) was computed, a measure to quantify the relative importance of a node within the network. Then we derived color-coded head plots based on BC values and calculated the center of mass (the exact middle had x and y values of 0). A shifting of the hub locations was defined as a shift of the center of mass on the y-axis across groups. Multivariate general linear models with PLI or BC values as dependent variables and the groups as continuous variables were used in the five conventional frequency bands. We found that functional connectivity decreases with increasing disease severity in the alpha band. All, except for posterior, regions showed increasing BC values with increasing disease severity. The center of mass shifted from posterior to more anterior regions with increasing disease severity in the higher frequency bands, indicating a loss of relative functional importance of the posterior brain regions. In conclusion, we observed decreasing functional connectivity in the posterior regions, together with a shifted hub location from

  10. Looking into Pandora's Box: The Content of Sci-Hub and its Usage.

    Science.gov (United States)

    Greshake, Bastian

    2017-01-01

    Despite the growth of Open Access, potentially illegally circumventing paywalls to access scholarly publications is becoming a more mainstream phenomenon. The web service Sci-Hub is amongst the biggest facilitators of this, offering free access to around 62 million publications. So far it is not well studied how and why its users are accessing publications through Sci-Hub. By utilizing the recently released corpus of Sci-Hub and comparing it to the data of  ~28 million downloads done through the service, this study tries to address some of these questions. The comparative analysis shows that both the usage and complete corpus is largely made up of recently published articles, with users disproportionately favoring newer articles and 35% of downloaded articles being published after 2013. These results hint that embargo periods before publications become Open Access are frequently circumnavigated using Guerilla Open Access approaches like Sci-Hub. On a journal level, the downloads show a bias towards some scholarly disciplines, especially Chemistry, suggesting increased barriers to access for these. Comparing the use and corpus on a publisher level, it becomes clear that only 11% of publishers are highly requested in comparison to the baseline frequency, while 45% of all publishers are significantly less accessed than expected. Despite this, the oligopoly of publishers is even more remarkable on the level of content consumption, with 80% of all downloads being published through only 9 publishers. All of this suggests that Sci-Hub is used by different populations and for a number of different reasons, and that there is still a lack of access to the published scientific record. A further analysis of these openly available data resources will undoubtedly be valuable for the investigation of academic publishing.

  11. When is hub gene selection better than standard meta-analysis?

    Directory of Open Access Journals (Sweden)

    Peter Langfelder

    Full Text Available Since hub nodes have been found to play important roles in many networks, highly connected hub genes are expected to play an important role in biology as well. However, the empirical evidence remains ambiguous. An open question is whether (or when hub gene selection leads to more meaningful gene lists than a standard statistical analysis based on significance testing when analyzing genomic data sets (e.g., gene expression or DNA methylation data. Here we address this question for the special case when multiple genomic data sets are available. This is of great practical importance since for many research questions multiple data sets are publicly available. In this case, the data analyst can decide between a standard statistical approach (e.g., based on meta-analysis and a co-expression network analysis approach that selects intramodular hubs in consensus modules. We assess the performance of these two types of approaches according to two criteria. The first criterion evaluates the biological insights gained and is relevant in basic research. The second criterion evaluates the validation success (reproducibility in independent data sets and often applies in clinical diagnostic or prognostic applications. We compare meta-analysis with consensus network analysis based on weighted correlation network analysis (WGCNA in three comprehensive and unbiased empirical studies: (1 Finding genes predictive of lung cancer survival, (2 finding methylation markers related to age, and (3 finding mouse genes related to total cholesterol. The results demonstrate that intramodular hub gene status with respect to consensus modules is more useful than a meta-analysis p-value when identifying biologically meaningful gene lists (reflecting criterion 1. However, standard meta-analysis methods perform as good as (if not better than a consensus network approach in terms of validation success (criterion 2. The article also reports a comparison of meta-analysis techniques

  12. Experiments With Height-dependent Parameterizations For Limb Profile Retrievals

    Science.gov (United States)

    Schwarz, G.; Hilgers, S.

    The implementation and validation of a level 2 processor for MIPAS - an atmospheric limb sounding instrument to be flown on the upcoming ENVISAT mission - led to a number of experiments with flexible data structures used for the retrieval of trace gas profiles. Besides the basic retrieval methods and the selected software concepts, these data structures represent one of the mainstays of the retrieval software; their flexibility has an immediate impact on the capabilities and the performance of the retrieval software. In particular, we compared the layout and implementation of data structures allowing the retrieval of trace gases and ancillary information with various methods on different height grids, the use of height dependent parameters and constraints, as well as the manipulation of the corresponding data during interpolations. Typical examples are nominal and actual measurement grids, user-oriented retrieval grids, libraries of atmospheric parameters, height dependent regularization param- eters, variances and co-variances, Jacobians (i.e. derivatives), a priori information, eigenvectors, and instrumental parameters. We will demonstrate typical examples outlining the additional retrieval performance offered by flexible data structures with respect to their implementation effort, and the risks involved during test and validation.

  13. SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity.

    Science.gov (United States)

    Lee, Kangjoo; Lina, Jean-Marc; Gotman, Jean; Grova, Christophe

    2016-07-01

    Functional hubs are defined as the specific brain regions with dense connections to other regions in a functional brain network. Among them, connector hubs are of great interests, as they are assumed to promote global and hierarchical communications between functionally specialized networks. Damage to connector hubs may have a more crucial effect on the system than does damage to other hubs. Hubs in graph theory are often identified from a correlation matrix, and classified as connector hubs when the hubs are more connected to regions in other networks than within the networks to which they belong. However, the identification of hubs from functional data is more complex than that from structural data, notably because of the inherent problem of multicollinearity between temporal dynamics within a functional network. In this context, we developed and validated a method to reliably identify connectors and corresponding overlapping network structure from resting-state fMRI. This new method is actually handling the multicollinearity issue, since it does not rely on counting the number of connections from a thresholded correlation matrix. The novelty of the proposed method is that besides counting the number of networks involved in each voxel, it allows us to identify which networks are actually involved in each voxel, using a data-driven sparse general linear model in order to identify brain regions involved in more than one network. Moreover, we added a bootstrap resampling strategy to assess statistically the reproducibility of our results at the single subject level. The unified framework is called SPARK, i.e. SParsity-based Analysis of Reliable k-hubness, where k-hubness denotes the number of networks overlapping in each voxel. The accuracy and robustness of SPARK were evaluated using two dimensional box simulations and realistic simulations that examined detection of artificial hubs generated on real data. Then, test/retest reliability of the method was assessed

  14. Development of large Area Covering Height Model

    Science.gov (United States)

    Jacobsen, K.

    2014-04-01

    Height information is a basic part of topographic mapping. Only in special areas frequent update of height models is required, usually the update cycle is quite lower as for horizontal map information. Some height models are available free of charge in the internet; for commercial height models a fee has to be paid. Mostly digital surface models (DSM) with the height of the visible surface are given and not the bare ground height, as required for standard mapping. Nevertheless by filtering of DSM, digital terrain models (DTM) with the height of the bare ground can be generated with the exception of dense forest areas where no height of the bare ground is available. These height models may be better as the DTM of some survey administrations. In addition several DTM from national survey administrations are classified, so as alternative the commercial or free of charge available information from internet can be used. The widely used SRTM DSM is available also as ACE-2 GDEM corrected by altimeter data for systematic height errors caused by vegetation and orientation errors. But the ACE-2 GDEM did not respect neighbourhood information. With the worldwide covering TanDEM-X height model, distributed starting 2014 by Airbus Defence and Space (former ASTRIUM) as WorldDEM, higher level of details and accuracy is reached as with other large area covering height models. At first the raw-version of WorldDEM will be available, followed by an edited version and finally as WorldDEM-DTM a height model of the bare ground. With 12 m spacing and a relative standard deviation of 1.2 m within an area of 1° x 1° an accuracy and resolution level is reached, satisfying also for larger map scales. For limited areas with the HDEM also a height model with 6 m spacing and a relative vertical accuracy of 0.5 m can be generated on demand. By bathymetric LiDAR and stereo images also the height of the sea floor can be determined if the water has satisfying transparency. Another method of getting

  15. Imagery and fear influence height perception.

    Science.gov (United States)

    Clerkin, Elise M; Cody, Meghan W; Stefanucci, Jeanine K; Proffitt, Dennis R; Teachman, Bethany A

    2009-04-01

    The current study tested whether height overestimation is related to height fear and influenced by images of falling. To assess perceptual biases, participants high (n=65) versus low (n=64) in height fear estimated the vertical extents of two balconies using a visual matching task. On one of the balconies, participants engaged in an imagery exercise designed to enhance the subjective sense that they were acting in a dangerous environment by picturing themselves falling. As expected, we found that individuals overestimated the balcony's height more after they imagined themselves falling, particularly if they were already afraid of heights. These findings suggest that height fear may serve as a vulnerability factor that leads to perceptual biases when triggered by a stressor (in this case, images of falling).

  16. Statistical distribution of nonlinear random wave height

    Institute of Scientific and Technical Information of China (English)

    HOU; Yijun; GUO; Peifang; SONG; Guiting; SONG; Jinbao; YIN; Baoshu; ZHAO; Xixi

    2006-01-01

    A statistical model of random wave is developed using Stokes wave theory of water wave dynamics. A new nonlinear probability distribution function of wave height is presented. The results indicate that wave steepness not only could be a parameter of the distribution function of wave height but also could reflect the degree of wave height distribution deviation from the Rayleigh distribution. The new wave height distribution overcomes the problem of Rayleigh distribution that the prediction of big wave is overestimated and the general wave is underestimated. The prediction of small probability wave height value of new distribution is also smaller than that of Rayleigh distribution. Wave height data taken from East China Normal University are used to verify the new distribution. The results indicate that the new distribution fits the measurements much better than the Rayleigh distribution.

  17. Kinetic Constrained Optimization of the Golf Swing Hub Path

    Directory of Open Access Journals (Sweden)

    Steven M. Nesbit

    2014-12-01

    Full Text Available This study details an optimization of the golf swing, where the hand path and club angular trajectories are manipulated. The optimization goal was to maximize club head velocity at impact within the interaction kinetic limitations (force, torque, work, and power of the golfer as determined through the analysis of a typical swing using a two-dimensional dynamic model. The study was applied to four subjects with diverse swing capabilities and styles. It was determined that it is possible for all subjects to increase their club head velocity at impact within their respective kinetic limitations through combined modifications to their respective hand path and club angular trajectories. The manner of the modifications, the degree of velocity improvement, the amount of kinetic reduction, and the associated kinetic limitation quantities were subject dependent. By artificially minimizing selected kinetic inputs within the optimization algorithm, it was possible to identify swing trajectory characteristics that indicated relative kinetic weaknesses of a subject. Practical implications are offered based upon the findings of the study.

  18. Height-integrated conductivity in auroral substorms - 2. Modeling

    DEFF Research Database (Denmark)

    Gjerløv, Jesper Wittendorff; Hoffman, R.A.

    2000-01-01

    Calculations of height-integrated conductivity from 31 individual Dynamics Explorer (DE 2) substorm crossings presented by Gjerloev and Hoffman [this issue] are used to compile empirical models of the height-integrated Pedersen and Hall conductivities (conductances) in a bulge-type auroral substorm....... Global auroral images obtained by Dynamics Explorer 1 (DE 1) were used to select substorms displaying a typical bulge-type emission pattern and each individual DE 2 pass was positioned with respect to key features in the observed emission pattern. The conductances were calculated for each DE 2 pass using...... electron precipitation data and a monoenergetic conductance model. All passes were divided into six different sectors, and average conductance profiles were carefully deduced for each of these sectors. Using a simple boxcar filter, smoothed average sector passes were calculated and from linear...

  19. Sharing environmental models: An Approach using GitHub repositories and Web Processing Services

    Science.gov (United States)

    Stasch, Christoph; Nuest, Daniel; Pross, Benjamin

    2016-04-01

    The GLUES (Global Assessment of Land Use Dynamics, Greenhouse Gas Emissions and Ecosystem Services) project established a spatial data infrastructure for scientific geospatial data and metadata (http://geoportal-glues.ufz.de), where different regional collaborative projects researching the impacts of climate and socio-economic changes on sustainable land management can share their underlying base scenarios and datasets. One goal of the project is to ease the sharing of computational models between institutions and to make them easily executable in Web-based infrastructures. In this work, we present such an approach for sharing computational models relying on GitHub repositories (http://github.com) and Web Processing Services. At first, model providers upload their model implementations to GitHub repositories in order to share them with others. The GitHub platform allows users to submit changes to the model code. The changes can be discussed and reviewed before merging them. However, while GitHub allows sharing and collaborating of model source code, it does not actually allow running these models, which requires efforts to transfer the implementation to a model execution framework. We thus have extended an existing implementation of the OGC Web Processing Service standard (http://www.opengeospatial.org/standards/wps), the 52°North Web Processing Service (http://52north.org/wps) platform to retrieve all model implementations from a git (http://git-scm.com) repository and add them to the collection of published geoprocesses. The current implementation is restricted to models implemented as R scripts using WPS4R annotations (Hinz et al.) and to Java algorithms using the 52°North WPS Java API. The models hence become executable through a standardized Web API by multiple clients such as desktop or browser GIS and modelling frameworks. If the model code is changed on the GitHub platform, the changes are retrieved by the service and the processes will be updated

  20. Adult height, nutrition, and population health.

    Science.gov (United States)

    Perkins, Jessica M; Subramanian, S V; Davey Smith, George; Özaltin, Emre

    2016-03-01

    In this review, the potential causes and consequences of adult height, a measure of cumulative net nutrition, in modern populations are summarized. The mechanisms linking adult height and health are examined, with a focus on the role of potential confounders. Evidence across studies indicates that short adult height (reflecting growth retardation) in low- and middle-income countries is driven by environmental conditions, especially net nutrition during early years. Some of the associations of height with health and social outcomes potentially reflect the association between these environmental factors and such outcomes. These conditions are manifested in the substantial differences in adult height that exist between and within countries and over time. This review suggests that adult height is a useful marker of variation in cumulative net nutrition, biological deprivation, and standard of living between and within populations and should be routinely measured. Linkages between adult height and health, within and across generations, suggest that adult height may be a potential tool for monitoring health conditions and that programs focused on offspring outcomes may consider maternal height as a potentially important influence.

  1. The role of conceptual knowledge in understanding synaesthesia: Evaluating contemporary findings from a “hub-and-spokes” perspective

    Science.gov (United States)

    Chiou, Rocco

    2014-01-01

    Synesthesia is a phenomenon in which stimulation in one sensory modality triggers involuntary experiences typically not associated with that stimulation. Inducing stimuli (inducers) and synesthetic experiences (concurrents) may occur within the same modality (e.g., seeing colors while reading achromatic text) or span across different modalities (e.g., tasting flavors while listening to music). Although there has been considerable progress over the last decade in understanding the cognitive and neural mechanisms of synesthesia, the focus of current neurocognitive models of synesthesia does not encompass many crucial psychophysical characteristics documented in behavioral research. Prominent theories of the neurophysiological basis of synesthesia construe it as a perceptual phenomenon and hence focus primarily on the modality-specific brain regions for perception. Many behavioral studies, however, suggest an essential role for conceptual-level information in synesthesia. For example, there is evidence that synesthetic experience arises subsequent to identification of an inducing stimulus, differs substantially from real perceptual events, can be akin to perceptual memory, and is susceptible to lexical/semantic contexts. These data suggest that neural mechanisms lying beyond the realm of the perceptual cortex (especially the visual system), such as regions subserving conceptual knowledge, may play pivotal roles in the neural architecture of synesthesia. Here we discuss the significance of non-perceptual mechanisms that call for a re-evaluation of the emphasis on synesthesia as a perceptual phenomenon. We also review recent studies which hint that some aspects of synesthesia resemble our general conceptual knowledge for object attributes, at both psychophysical and neural levels. We then present a conceptual-mediation model of synesthesia in which the inducer and concurrent are linked within a conceptual-level representation. This “inducer-to-concurrent” nexus is

  2. KINEMATIC ANALYSES OF THE GOLF SWING HUB PATH AND ITS ROLE IN GOLFER/CLUB KINETIC TRANSFERS

    Directory of Open Access Journals (Sweden)

    Steven M. Nesbit

    2009-06-01

    Full Text Available This study analyzed the fundamental geometric and kinematic characteristics of the swing hub path of the golf shot for four diverse subjects. In addition, the role of the hub path geometry in transferring the kinetic quantities from the golfer to the club were investigated. The hub path was found to have a complex geometry with significantly changing radii, and a constantly moving center-of-curvature during the downswing for all subjects. While the size and shape of the hub path differed considerably among the subjects, a three phase radius-based pattern was revealed that aligned with distinct stages of the downswing. Artificially controlling and optimizing the hub path of the better golfer in the group indicated that a non-circular hub path was superior to a constant radius path in minimizing the kinetic loading while generating the highest possible club head velocity. The shape and purpose of the hub path geometry appears to result from a complex combination of achieving equilibrium between the golfer and the club, and a purposeful configuring of the path to control the outward movement of the club while minimizing the kinetic loading on the golfer yet transferring the maximum kinetic quantities to the club. Describing the downswing relative to the hub path phasing is presented and was found to be informative since the phases align with significant swing, kinetic and kinematic markers. These findings challenge golf swing modeling methodologies which fix the center-of-curvature of the hub path thus constraining it to constant radius motion

  3. Kinetic constrained optimization of the golf swing hub path.

    Science.gov (United States)

    Nesbit, Steven M; McGinnis, Ryan S

    2014-12-01

    This study details an optimization of the golf swing, where the hand path and club angular trajectories are manipulated. The optimization goal was to maximize club head velocity at impact within the interaction kinetic limitations (force, torque, work, and power) of the golfer as determined through the analysis of a typical swing using a two-dimensional dynamic model. The study was applied to four subjects with diverse swing capabilities and styles. It was determined that it is possible for all subjects to increase their club head velocity at impact within their respective kinetic limitations through combined modifications to their respective hand path and club angular trajectories. The manner of the modifications, the degree of velocity improvement, the amount of kinetic reduction, and the associated kinetic limitation quantities were subject dependent. By artificially minimizing selected kinetic inputs within the optimization algorithm, it was possible to identify swing trajectory characteristics that indicated relative kinetic weaknesses of a subject. Practical implications are offered based upon the findings of the study. Key PointsThe hand path trajectory is an important characteristic of the golf swing and greatly affects club head velocity and golfer/club energy transfer.It is possible to increase the energy transfer from the golfer to the club by modifying the hand path and swing trajectories without increasing the kinetic output demands on the golfer.It is possible to identify relative kinetic output strengths and weakness of a golfer through assessment of the hand path and swing trajectories.Increasing any one of the kinetic outputs of the golfer can potentially increase the club head velocity at impact.The hand path trajectory has important influences over the club swing trajectory.

  4. Microbial Hub Taxa Link Host and Abiotic Factors to Plant Microbiome Variation.

    Directory of Open Access Journals (Sweden)

    Matthew T Agler

    2016-01-01

    Full Text Available Plant-associated microorganisms have been shown to critically affect host physiology and performance, suggesting that evolution and ecology of plants and animals can only be understood in a holobiont (host and its associated organisms context. Host-associated microbial community structures are affected by abiotic and host factors, and increased attention is given to the role of the microbiome in interactions such as pathogen inhibition. However, little is known about how these factors act on the microbial community, and especially what role microbe-microbe interaction dynamics play. We have begun to address this knowledge gap for phyllosphere microbiomes of plants by simultaneously studying three major groups of Arabidopsis thaliana symbionts (bacteria, fungi and oomycetes using a systems biology approach. We evaluated multiple potential factors of microbial community control: we sampled various wild A. thaliana populations at different times, performed field plantings with different host genotypes, and implemented successive host colonization experiments under lab conditions where abiotic factors, host genotype, and pathogen colonization was manipulated. Our results indicate that both abiotic factors and host genotype interact to affect plant colonization by all three groups of microbes. Considering microbe-microbe interactions, however, uncovered a network of interkingdom interactions with significant contributions to community structure. As in other scale-free networks, a small number of taxa, which we call microbial "hubs," are strongly interconnected and have a severe effect on communities. By documenting these microbe-microbe interactions, we uncover an important mechanism explaining how abiotic factors and host genotypic signatures control microbial communities. In short, they act directly on "hub" microbes, which, via microbe-microbe interactions, transmit the effects to the microbial community. We analyzed two "hub" microbes (the

  5. 基于 Supply-hub的生产与配送协同决策%Research on Assembly Supply Chain Collaborative Decision-making Based on Supply-hub

    Institute of Scientific and Technical Information of China (English)

    丁惠芳; 袁晓丽

    2015-01-01

    文中旨在从供应和供应商的角度出发,以基于Supply-hub的协同决策为研究对象,重点研究其生产和配送的协同决策模式,从理论上和实证上分析和比较两种典型的决策模式(即供应商和Supply-hub运营商分散决策模式、Supply-hub运营商整体决策模式),从成本和效率两个方面研究两种决策模式的优劣。%This papers focuses on the production and distribution mode of collaborative decision-making from supply and supplier,and analyses and compares the cost and efficiency of two kinds of typical decision models( i.e.suppliers and Supply-hub operator independent decision model and Supply-hub operator overall decision model) in theory and empirical.

  6. From hub proteins to hub modules: the relationship between essentiality and centrality in the yeast interactome at different scales of organization.

    Directory of Open Access Journals (Sweden)

    Jimin Song

    Full Text Available Numerous studies have suggested that hub proteins in the S. cerevisiae physical interaction network are more likely to be essential than other proteins. The proposed reasons underlying this observed relationship between topology and functioning have been subject to some controversy, with recent work suggesting that it arises due to the participation of hub proteins in essential complexes and processes. However, do these essential modules themselves have distinct network characteristics, and how do their essential proteins differ in their topological properties from their non-essential proteins? We aimed to advance our understanding of protein essentiality by analyzing proteins, complexes and processes within their broader functional context and by considering physical interactions both within and across complexes and biological processes. In agreement with the view that essentiality is a modular property, we found that the number of intracomplex or intraprocess interactions that a protein has is a better indicator of its essentiality than its overall number of interactions. Moreover, we found that within an essential complex, its essential proteins have on average more interactions, especially intracomplex interactions, than its non-essential proteins. Finally, we built a module-level interaction network and found that essential complexes and processes tend to have higher interaction degrees in this network than non-essential complexes and processes; that is, they exhibit a larger amount of functional cross-talk than their non-essential counterparts.

  7. Evolutionary perspectives on human height variation

    NARCIS (Netherlands)

    Stulp, Gert; Barrett, Louise

    2016-01-01

    Human height is a highly variable trait, both within and between populations, has a high heritability, and influences the manner in which people behave and are treated in society. Although we know much about human height, this information has rarely been brought together in a comprehensive, systemat

  8. Local average height distribution of fluctuating interfaces

    Science.gov (United States)

    Smith, Naftali R.; Meerson, Baruch; Sasorov, Pavel V.

    2017-01-01

    Height fluctuations of growing surfaces can be characterized by the probability distribution of height in a spatial point at a finite time. Recently there has been spectacular progress in the studies of this quantity for the Kardar-Parisi-Zhang (KPZ) equation in 1 +1 dimensions. Here we notice that, at or above a critical dimension, the finite-time one-point height distribution is ill defined in a broad class of linear surface growth models unless the model is regularized at small scales. The regularization via a system-dependent small-scale cutoff leads to a partial loss of universality. As a possible alternative, we introduce a local average height. For the linear models, the probability density of this quantity is well defined in any dimension. The weak-noise theory for these models yields the "optimal path" of the interface conditioned on a nonequilibrium fluctuation of the local average height. As an illustration, we consider the conserved Edwards-Wilkinson (EW) equation, where, without regularization, the finite-time one-point height distribution is ill defined in all physical dimensions. We also determine the optimal path of the interface in a closely related problem of the finite-time height-difference distribution for the nonconserved EW equation in 1 +1 dimension. Finally, we discuss a UV catastrophe in the finite-time one-point distribution of height in the (nonregularized) KPZ equation in 2 +1 dimensions.

  9. 47 CFR 95.51 - Antenna height.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Antenna height. 95.51 Section 95.51... SERVICES General Mobile Radio Service (GMRS) § 95.51 Antenna height. (a) Certain antenna structures used in... this chapter. (b) The antenna for a small base station or for a small control station must not be...

  10. Omni directional mobile robot capable of variable foot printing based on hub type drive module

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyo Joong; Cho, Chang Nho; Kim, Hwi Su; Song, Jae Bok [Korea Univ., Seoul (Korea, Republic of)

    2012-03-15

    In recent years, an increased amount of research has been carried out on mobile robots to improve the performance of service robots. Mobile robots maximize the mobility of service robots, thus allowing them to work in different areas. However, conventional service robots have their center of mass placed high above the ground, which may cause them to fall when moving at high speed. Furthermore, hub type actuators, which are often used for mobile robots, are large and expensive. In this study, we propose a mobile robot with a hub type actuator unit and a variable footprint mechanism. The proposed variable footprint mechanism greatly improves the stability and mobility of the robot, allowing it to move freely in a narrow space and carry out various tasks. The performance of the proposed robot is verified experimentally.

  11. Replenishment policy and inventory optimization for supply-hub with liability period consideration

    Institute of Scientific and Technical Information of China (English)

    李果; 黄焜; 姚琦; 马士华

    2013-01-01

    A replenishment decision-making model for supply-hub is firstly established from the angle of supplier, and optimal replenishment decision of the supplier is analyzed. Then, inventory optimization model for supply-hub is formulated from the angle of the manufacturer, and the optimization algorithm for obtaining optimal inventory levels is given. The result shows that liability period decides the share of the inventory cost between two sides in supply chain. With the increase of liability period, the service level has been quickly reduced even though the manufacturer’s cost has been cut down by transferring the inventory cost to the supplier. As to the safety inventory, if the lower bound of components safety inventory increases, the supplier’s cost will rise up more slowly than the liability period does, while the service levels increases as the safety inventory’s lower bound is raised.

  12. Dynamic network participation of functional connectivity hubs assessed by resting-state fMRI

    Directory of Open Access Journals (Sweden)

    Alexander eSchaefer

    2014-05-01

    Full Text Available Network studies of large-scale brain connectivity have demonstrated that highly connected areas, or ‘hubs’, are a key feature of human functional and structural brain organization. We use resting-state functional MRI data and connectivity clustering to identify multi network hubs and show that while hubs can belong to multiple networks their degree of integration into these different networks varies dynamically over time. In addition, we found that these network dynamics were inversely related to positive self-generated thoughts reported by individuals and were further decreased with older age. Moreover, the left caudate varied its degree of participation between a default mode subnetwork and a limbic network. This variation was predictive of individual differences in the reports of past-related thoughts. These results support an association between ongoing thought processes and network dynamics and offer a new approach to investigate the brain dynamics underlying mental experience.

  13. Fast reversible learning based on neurons functioning as anisotropic multiplex hubs

    Science.gov (United States)

    Vardi, Roni; Goldental, Amir; Sheinin, Anton; Sardi, Shira; Kanter, Ido

    2017-05-01

    Neural networks are composed of neurons and synapses, which are responsible for learning in a slow adaptive dynamical process. Here we experimentally show that neurons act like independent anisotropic multiplex hubs, which relay and mute incoming signals following their input directions. Theoretically, the observed information routing enriches the computational capabilities of neurons by allowing, for instance, equalization among different information routes in the network, as well as high-frequency transmission of complex time-dependent signals constructed via several parallel routes. In addition, this kind of hubs adaptively eliminate very noisy neurons from the dynamics of the network, preventing masking of information transmission. The timescales for these features are several seconds at most, as opposed to the imprint of information by the synaptic plasticity, a process which exceeds minutes. Results open the horizon to the understanding of fast and adaptive learning realities in higher cognitive brain's functionalities.

  14. Clinical bioethics integration, sustainability, and accountability: the Hub and Spokes Strategy.

    Science.gov (United States)

    MacRae, S; Chidwick, P; Berry, S; Secker, B; Hébert, P; Shaul, R Zlotnik; Faith, K; Singer, P A

    2005-05-01

    The "lone" clinical bioethicist working in a large, multisite hospital faces considerable challenges. While attempting to build ethics capacity and sustain a demanding range of responsibilities, he or she must also achieve an acceptable level of integration, sustainability, and accountability within a complex organisational structure. In an effort to address such inherent demands and to create a platform towards better evaluation and effectiveness, the Clinical Ethics Group at the Joint Centre for Bioethics at the University of Toronto is implementing the Hub and Spokes Strategy at seven hospitals. The goal of the Hub and Spokes Strategy is to foster an ethical climate and strengthen ethics capacity broadly throughout healthcare settings as well as create models in clinical bioethics that are excellent and effective.

  15. Giant hub Src and Syk tyrosine kinase thermodynamic profiles recapitulate evolution

    Science.gov (United States)

    Phillips, J. C.

    2017-10-01

    Thermodynamic scaling theory, previously applied mainly to small proteins, here analyzes quantitative evolution of the titled functional network giant hub enzymes. The broad domain structure identified homologically is confirmed hydropathically using amino acid sequences only. The most surprising results concern the evolution of the tyrosine kinase globular surface roughness from avians to mammals, which is first order, compared to the evolution within mammals from rodents to humans, which is second order. The mystery of the unique amide terminal region of proto oncogene tyrosine protein kinase is resolved by the discovery there of a rare hydroneutral septad targeting cluster, which is paralleled by an equally rare octad catalytic cluster in tyrosine kinase in humans and a few other species (cat and dog). These results, which go far towards explaining why these proteins are among the largest giant hubs in protein interaction networks, use no adjustable parameters.

  16. Unveiling the early-stage anatomy of a protocluster hub with ALMA

    Science.gov (United States)

    Henshaw, J. D.; Jiménez-Serra, I.; Longmore, S. N.; Caselli, P.; Pineda, J. E.; Avison, A.; Barnes, A. T.; Tan, J. C.; Fontani, F.

    2017-01-01

    High-mass stars shape the interstellar medium in galaxies, and yet, largely because the initial conditions are poorly constrained, we do not know how they form. One possibility is that high-mass stars and star clusters form at the junction of filamentary networks, referred to as `hubs'. In this Letter we present the complex anatomy of a protocluster hub within an Infrared Dark Cloud (IRDC), G035.39-00.33, believed to be in an early phase of its evolution. We use high-angular resolution ({θmaj, θmin} = {1.4 arcsec, 0.8 arcsec} ˜ {0.02 pc, 0.01 pc}) and high-sensitivity (0.2 mJy beam-1; ˜0.2 M⊙) 1.07 mm dust continuum observations from the Atacama Large Millimeter Array (ALMA) to identify a network of narrow, 0.028 ± 0.005 pc wide, filamentary structures. These are a factor of ≳3 narrower than the proposed `quasi-universal' ˜0.1 pc width of interstellar filaments. Additionally, 28 compact objects are reported, spanning a mass range 0.3 M⊙ < Mc < 10.4 M⊙. This indicates that at least some low-mass objects are forming coevally with more massive counterparts. Comparing to the popular `bead-on-a-string' analogy, the protocluster hub is poorly represented by a monolithic clump embedded within a single filament. Instead, it comprises multiple intra-hub filaments, each of which retains its integrity as an independent structure and possesses its own embedded core population.

  17. Hub network design for sparse travel demand within the African aviation industry

    CSIR Research Space (South Africa)

    Ssamula, B

    2007-07-01

    Full Text Available as well as corruption leading to insufficient funds to manage national airlines. In order to align African Aviation with policies of deregulation and liberalisation already implemented in North America and Western Europe and to prevent the collapse... for each cluster was based on using the following factors: high passenger demand, infrastructure, technology advancement, number of flights operating, number of airlines operating, hub capabilities or function at airline or geographical level, as shown...

  18. Sensor Networks Hierarchical Optimization Model for Security Monitoring in High-Speed Railway Transport Hub

    Directory of Open Access Journals (Sweden)

    Zhengyu Xie

    2015-01-01

    Full Text Available We consider the sensor networks hierarchical optimization problem in high-speed railway transport hub (HRTH. The sensor networks are optimized from three hierarchies which are key area sensors optimization, passenger line sensors optimization, and whole area sensors optimization. Case study on a specific HRTH in China showed that the hierarchical optimization method is effective to optimize the sensor networks for security monitoring in HRTH.

  19. Wheels, hubs and spokes: incorporating a scorecard into a business continuity programme.

    Science.gov (United States)

    Stourac, Tracy

    2014-01-01

    A scorecard can provide much more than periodic measurements; it can actually serve as the 'hub' of a programme. By taking a strategic look at what one is trying to accomplish, using consistent messaging, following a flexible but defined process and creating an actionable report for the senior leadership, a programme can be built that not only gets attention but is also efficient and effective. The scorecard establishes accountability and consistency while creating a brand for a business continuity programme.

  20. Free vibrations of a flexible tapered arm attached to a compliant hub

    Science.gov (United States)

    Craver, W. Lionel, Jr.; Carrasco, Armando H.

    1991-05-01

    A single link flexible robot arm can be modeled as a Bernoulli Euler beam to describe its dynamic behavior. The first six natural frequencies for a flexible uniform beam attached to a compliant hub undergoing free vibration have previously been presented. This article extends the work to that of a linearly tapered robot arm. The equations of motion are presented and the characteristic determinant is derived. The determinant is then solved for the first five natural frequencies of the system.

  1. Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis.

    Science.gov (United States)

    Luo, Xiaoping; Guo, Linghong; Dai, Xi-Jian; Wang, Qinglai; Zhu, Wenzhong; Miao, Xinjun; Gong, Honghan

    2017-01-01

    To explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features. Twenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years) and 24 age- and education-matched male healthy controls (mean age, 50.29±8.92 years) were recruited. The alcohol use disorders identification test and the severity of alcohol dependence questionnaire (SADQ) were administered to assess the severity of alcohol craving. Voxelwise degree centrality approach was used to assess the abnormal intrinsic functional hubs features in alcohol dependence. Simple linear regression analysis was performed to investigate the relationships between the clinical features and abnormal intrinsic functional hubs. Compared with healthy controls, alcohol dependence subjects exhibited significantly different degree centrality values in widespread left lateralization brain areas, including higher degree centrality values in the left precentral gyrus (BA 6), right hippocampus (BA 35, 36), and left orbitofrontal cortex (BA 11) and lower degree centrality values in the left cerebellum posterior lobe, bilateral secondary visual network (BA 18), and left precuneus (BA 7, 19). SADQ revealed a negative linear correlation with the degree centrality value in the left precentral gyrus (R(2)=0.296, P=0.006). The specific abnormal intrinsic functional hubs appear to be disrupted by alcohol intoxication, which implicates at least three principal neural systems: including cerebellar, executive control, and visual cortex, which may further affect the normal motor behavior such as an explicit type of impaired driving behavior. These findings expand our understanding of the functional characteristics of alcohol dependence and may provide a new insight into the understanding of the dysfunction and pathophysiology of alcohol dependence.

  2. Growing with Global Production Sharing: The Tale of Penang Export Hub

    OpenAIRE

    Prema-chandra Athukorala

    2011-01-01

    Global production sharing—the division of production processes into geographically separated stages—is a central feature of economic globalization. This study seeks to broaden our understanding of global production sharing, and to explore policy options for developing countries to engage effectively in production networks through a case study of the export production hub in the State of Penang, Malaysia. The findings uphold Penang as a unique example of marrying national development strat...

  3. Building a static website with Jekyll and GitHub Pages

    OpenAIRE

    Amanda Visconti

    2016-01-01

    This lesson is for you if you’d like an entirely free, easy-to-maintain, preservation-friendly, secure website over which you have full control, such as a scholarly blog, project website, or online portfolio. At the end of this lesson, you’ll have learned to use technology including Jekyll static site generation and GitHub Pages hosting to create a basic live website where you can publish content that other people can visit.

  4. Establishment of a Hub for the Light Water Reactor Sustainability Online Monitoring Community

    Energy Technology Data Exchange (ETDEWEB)

    Nancy J. Lybeck; Magdy S. Tawfik; Binh T. Pham

    2011-08-01

    Implementation of online monitoring and prognostics in existing U.S. nuclear power plants will involve coordinating the efforts of national laboratories, utilities, universities, and private companies. Internet-based collaborative work environments provide necessary communication tools to facilitate interaction between geographically diverse participants. Available technologies were considered, and a collaborative workspace was established at INL as a hub for the light water reactor sustainability online monitoring community.

  5. Smoking restrictions in large-hub airports --- United States, 2002 and 2010.

    Science.gov (United States)

    2010-11-19

    Secondhand smoke (SHS) exposure causes death and disease in both nonsmoking adults and children, including cancer, cardiovascular and respiratory diseases. SHS exposure causes an estimated 46,000 heart disease deaths and 3,400 lung cancer deaths among U.S. nonsmoking adults annually. Adopting policies that completely eliminate smoking in all indoor areas is the only effective way to eliminate involuntary SHS exposure. In 2009, an estimated 696 million aircraft passenger boardings occurred in the United States. A 2002 survey of airport smoking policies found that 42% of 31 large-hub U.S. airports had policies requiring all indoor areas to be smoke-free. To update that finding, CDC analyzed the smoking policies of airports categorized as large-hub in 2010. This report summarizes the results of that analysis, which found that, although 22 (76%) of the 29 large-hub airports surveyed were smoke-free indoors, seven airports permitted smoking in certain indoor locations, including three of the five busiest airports. Although a majority of airports reported having specifically designated smoking areas outdoors in 2010 (79%) and/or prohibiting smoking within a minimum distance of entryways (69%), no airport completely prohibited smoking on all airport property. Smoke-free policies at the state, local, or airport authority level are needed for all airports to protect air travelers and workers at airports from SHS.

  6. Penentuan Pelabuhan Hub untuk Crude Palm Oil (CPO Ekspor di Indonesia

    Directory of Open Access Journals (Sweden)

    Eko Andi Haranto

    2013-03-01

    Full Text Available CPO (Crude Palm Oil merupakan salah satu komoditi ekspor terbesar di Indonesia. Moda angkut darat dan sungai menjadi pilihan untuk didistribusikan menuju calon pelabuhan hub. Tugas Akhir ini bertujuan untuk merencanakan pola operasi armada pengangkut CPO, dan penentuan pelabuhan hub untuk ekspor CPO. Metode Transportasi digunakan untuk memilih pabrik pengolahan CPO sebagai pemasok utama. Dari hasil analisis didapatkan bahwa penggunaan moda darat menggunakan truk lebih optimal dibandingkan menggunakan tongkang hal ini dikarenakan kondisi sungai di Kalimantan Tengah yang dangkal. Dengan menggunakan metode transportasi didapatkan empat lokasi pabrik pengolahan minyak kelapa sawit. Pelabuhan hub yang terpilih berlokasi di Bagendang dan Bumi Harjo. Kedua titik tersebut dipilih karena sudah memiliki tangki timbun dan dermaga untuk ekspor CPO, selain itu pemilihan berdasarkan hasil analisa didapatkan biaya dari Pabrik PT. ATLANTIS ke Pelabuhan Bagendang dengan truk berukuran 10 ton memerlukan biaya sebesar Rp. 333.016,25/TRIP/TRUK. Pabrik PT. ATLANTIS II ke Pelabuhan Bagendang Rp. 237.868,75/TRIP/TRUK. Pabrik PT. TIGER ke Pelabuhan Bumi Harjo Rp. 475.737,50/TRIP/TRUK. PT. TIGER II merupakan pabrik yang dapat melakukan pengiriman langsung menggunakan tongkang berukuran 1800 DWT melewati sungai Barito, dengan biaya Rp.123.007.828,27,- /voyage.

  7. HIGH CYCLE FATIGUE RELIABILITY ANALYSIS ON ROTOR HUB BASED ON APPROXIMATION TECHNIQUE

    Institute of Scientific and Technical Information of China (English)

    姜年朝; 周光明; 张逊; 戴勇; 倪俊; 张志清

    2013-01-01

    A high cycle fatigue reliability analysis approach to helicopter rotor hub is proposed under working load spectrum .Automatic calculation for the approach is implemented through writing the calculating programs .In the system ,the modification of geometric model of rotor hub is controlled by several parameters ,and finite element method and S-N curve method are then employed to solve the fatigue life by automatically assigned parameters .A database between assigned parameters and fatigue life is obtained via Latin Hypercube Sampling (LHS) on toler-ance zone of rotor hub .Different data-fitting technologies are used and compared to determine a highest-precision approximation for this database .The parameters are assumed to be independent of each other and follow normal distributions .Fatigue reliability is then computed by the Monte Carlo (MC) method and the mean-value first order second moment (M FOSM ) method .Results show that the approach has high efficiency and precision ,and is suit-able for engineering application .

  8. A fractal growth model: Exploring the connection pattern of hubs in complex networks

    Science.gov (United States)

    Li, Dongyan; Wang, Xingyuan; Huang, Penghe

    2017-04-01

    Fractal is ubiquitous in many real-world networks. Previous researches showed that the strong disassortativity between the hub-nodes on all length scales was the key principle that gave rise to the fractal architecture of networks. Although fractal property emerged in some models, there were few researches about the fractal growth model and quantitative analyses about the strength of the disassortativity for fractal model. In this paper, we proposed a novel inverse renormalization method, named Box-based Preferential Attachment (BPA), to build the fractal growth models in which the Preferential Attachment was performed at box level. The proposed models provided a new framework that demonstrated small-world-fractal transition. Also, we firstly demonstrated the statistical characteristic of connection patterns of the hubs in fractal networks. The experimental results showed that, given proper growing scale and added edges, the proposed models could clearly show pure small-world or pure fractal or both of them. It also showed that the hub connection ratio showed normal distribution in many real-world networks. At last, the comparisons of connection pattern between the proposed models and the biological and technical networks were performed. The results gave useful reference for exploring the growth principle and for modeling the connection patterns for real-world networks.

  9. Scrubbing the hub of intravenous catheters with an alcohol wipe for 15 sec reduced neonatal sepsis.

    Science.gov (United States)

    Björkman, Louise; Ohlin, Andreas

    2015-03-01

    The aim of this study was to investigate whether scrubbing the hub of intravenous catheters with an alcohol wipe for 15 sec could reduce the incidence of neonatal sepsis in a level-three neonatal intensive care unit. We studied the incidence of neonatal sepsis caused by coagulase-negative staphylococci (CoNS) for 16.5 months before the initiative was launched on May 15, 2012 and then for a further 8.5 months after it was introduced. The hub routine was applied to all intravenous catheters. During the control period before the initiative was launched, there were nine cases of CoNS sepsis compared with no cases after it was introduced, resulting in a decrease in sepsis incidence from 1.5% to 0% with a risk reduction of 1.5% (0.53-2.58%) (p = 0.06). In the preterm infant population, the incidence of sepsis decreased from 3.6% to 0% (1.1-6.0%) (p = 0.11). Scrubbing the hub of intravenous catheters with an alcohol wipe for 15 sec seemed to be an efficient way of preventing sepsis caused by CoNS in newborn infants. However, the evidence for the benefits will remain weak until a large randomised trial has been completed. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  10. Simulation study on three casting processes for a marine propeller hub body

    Directory of Open Access Journals (Sweden)

    Wang Tongmin

    2013-11-01

    Full Text Available The mold filling and solidification process of a marine propeller hub were simulated using ProCAST? Three casting processes ?gravity casting, centrifugal casting and low pressure casting ?were compared in order to get the best process. The heat transfer coefficient of the casting/mold interface was determined using a reverse method. The simulated results of velocity, temperature and shrinkage porosity distribution were discussed in detail for the three casting processes. A smooth filling was found in all three casting processes, especially the low pressure casting exhibiting a better filling performance than the other two, but the solidification processes were different. The casting did not experience the sequential solidification, and the feeding paths were blocked, leading to shrinkage porosity defects in the riser and the bottom of the casting in gravity casting and in the upper zone of the casting in low pressure casting. While, the sequential solidification was well controlled in the solidification process of centrifugal casting, and majority of the shrinkage porosity defects can only be observed in the riser. It could be concluded that the centrifugal casting process is the most suitable casting process for the production of propeller hub body. The casting experiments verified the simulation results, and a defect-free propeller hub was obtained by centrifugal casting with a rotational speed of 150 r.in-1.

  11. Multi-task connectivity reveals flexible hubs for adaptive task control

    Science.gov (United States)

    Cole, Michael W.; Reynolds, Jeremy R.; Power, Jonathan D.; Repovs, Grega; Anticevic, Alan; Braver, Todd S.

    2013-01-01

    Extensive evidence suggests the human ability to adaptively implement a wide variety of tasks is preferentially due to the operation of a fronto-parietal brain network. We hypothesized that this network’s adaptability is made possible by ‘flexible hubs’ – brain regions that rapidly update their pattern of global functional connectivity according to task demands. We utilized recent advances in characterizing brain network organization and dynamics to identify mechanisms consistent with the flexible hub theory. We found that the fronto-parietal network’s brain-wide functional connectivity pattern shifted more than other networks’ across a variety of task states, and that these connectivity patterns could be used to identify the current task. Further, these patterns were consistent across practiced and novel tasks, suggesting reuse of flexible hub connectivity patterns facilitates adaptive (novel) task performance. Together, these findings support a central role for fronto-parietal flexible hubs in cognitive control and adaptive implementation of task demands generally. PMID:23892552

  12. Unsteady Velocity Measurements Taken Behind a Model Helicopter Rotor Hub in Forward Flight

    Science.gov (United States)

    Berry, John D.

    1997-01-01

    Drag caused by separated flow behind the hub of a helicopter has an adverse effect on aerodynamic performance of the aircraft. To determine the effect of separated flow on a configuration used extensively for helicopter aerodynamic investigations, an experiment was conducted using a laser velocimeter to measure velocities in the wake of a model helicopter hub operating at Mach-scaled conditions in forward flight. Velocity measurements were taken using a laser velocimeter with components in the vertical and downstream directions. Measurements were taken at 13 stations downstream from the rotor hub. At each station, measurements were taken in both a horizontal and vertical row of locations. These measurements were analyzed for harmonic content based on the rotor period of revolution. After accounting for these periodic velocities, the remaining unsteady velocities were treated as turbulence. Turbulence intensity distributions are presented. Average turbulent intensities ranged from approximately 2 percent of free stream to over 15 percent of free stream at specific locations and azimuths. The maximum average value of turbulence was located near the rear-facing region of the fuselage.

  13. Characteristics of steady vibration in a rotating hub-beam system

    Science.gov (United States)

    Zhao, Zhen; Liu, Caishan; Ma, Wei

    2016-02-01

    A rotating beam features a puzzling character in which its frequencies and modal shapes may vary with the hub's inertia and its rotating speed. To highlight the essential nature behind the vibration phenomena, we analyze the steady vibration of a rotating Euler-Bernoulli beam with a quasi-steady-state stretch. Newton's law is used to derive the equations governing the beam's elastic motion and the hub's rotation. A combination of these equations results in a nonlinear partial differential equation (PDE) that fully reflects the mutual interaction between the two kinds of motion. Via the Fourier series expansion within a finite interval of time, we reduce the PDE into an infinite system of a nonlinear ordinary differential equation (ODE) in spatial domain. We further nondimensionalize the ODE and discretize it via a difference method. The frequencies and modal shapes of a general rotating beam are then determined numerically. For a low-speed beam where the ignorance of geometric stiffening is feasible, the beam's vibration characteristics are solved analytically. We validate our numerical method and the analytical solutions by comparing with either the past experiments or the past numerical findings reported in existing literature. Finally, systematic simulations are performed to demonstrate how the beam's eigenfrequencies vary with the hub's inertia and rotating speed.

  14. Continuous Integration for Concurrent MOOSE Framework and Application Development on GitHub

    Directory of Open Access Journals (Sweden)

    Andrew E. Slaughter

    2015-11-01

    Full Text Available For the past several years, Idaho National Laboratory’s MOOSE framework team has employed modern software engineering techniques (continuous integration, joint application/framework source code repos- itories, automated regression testing, etc. in developing closed-source multiphysics simulation software (Gaston et al., 'Journal of Open Research Software' vol. 2, article e10, 2014. In March 2014, the MOOSE framework was released under an open source license on GitHub, significantly expanding and diversifying the pool of current active and potential future contributors on the project. Despite this recent growth, the same philosophy of concurrent framework and application development continues to guide the project’s development roadmap. Several specific practices, including techniques for managing multiple repositories, conducting automated regression testing, and implementing a cascading build process are discussed in this short paper. Special attention is given to describing the manner in which these practices naturally synergize with the GitHub API and GitHub-specific features such as issue tracking, Pull Requests, and project forks.

  15. Toxické látky vyšších hub

    OpenAIRE

    Ascherová, Adriana

    2009-01-01

    Tato práce je věnovaná problematice toxických látek vyšších hub. Tematicky je rozčleněna do tří oddílů. V první části se zabývá chemickým složením hub, kde klade hlavní důraz na obsah těžkých kovů a léčivých látek. Následující oddíl je zaměřen na houby jedovaté, jejich nejvýznamnější zástupce a mechanismus působení jedů. Část třetí objasňuje problematiku hub jedlých a otravy, které mohou způsobit. Především se jedná o biogenní aminy, práce popisuje jejich chemické složení, vznik, strukturu a ...

  16. The air transportation hub-and-spoke design problem: comparison between a continuous and a discrete solution method

    Directory of Open Access Journals (Sweden)

    Guina Sotomayor Alzamora

    2013-12-01

    Full Text Available The hub-and-spoke network design problem, also known as the hub location problem, aims to find the concentration points in a given network flow so that the sum of the distances of the linkages is minimized. In this work, we compare discrete solutions of this problem, given by the branch-and-cut method applied to the p-hub median model, with continuous solutions, given by the hyperbolic smoothing technique applied to a min-sum-min model. Computational experiments for particular instances of the Brazilian air transportation system, with the number of hubs varying from 2 to 8, are conducted with the support of a discretization heuristic and the Voronoi diagram.

  17. HuB localizes to polysomes and alters C/EBP-beta expression in 3T3-L1 adipocytes.

    Science.gov (United States)

    Gantt, Kira R; Jain, Renu G; Dudek, Ronald W; Pekala, Phillip H

    2004-01-16

    The RNA binding protein HuB was ectopically expressed in 3T3-L1 preadipocytes and localized primarily to the nucleus, as the cells differentiated HuB redistributed to the cytosol and on analysis localized to the dense polysomes. Electron micrographs confirm association of HuB with the ribosomes in the adipocytes consistent with a proposed role in control of translation and mRNA stability. Examination of the expression of C/EBP-beta in the cells expressing HuB relative to the parental 3T3-L1 adipocytes demonstrated an alteration in the LAP to LIP ratio. The data support a role for endogenous Hu proteins in the differentiation process, potentially affecting the rate of differentiation by controlling the concentration of the dominant negative transcription inhibitor, LIP.

  18. Increased height in diabetes mellitus corresponds to the predicted and the adult height

    NARCIS (Netherlands)

    Scheffer-Marinus, PD; Links, TP; Drayer, NM

    1999-01-01

    This study was conducted to analyse the effect of childhood-onset diabetes mellitus on adult height. The height at time of diagnosis of 35 children with insulin-dependent diabetes mellitus (IDDM) was compared with growth reference data. Predictions of the adult height were made at the time of diagno

  19. Parametric Investigation of the Effect of Hub Pitching Moment on Blade Vortex Interaction (BVI) Noise of an Isolated Rotor

    Science.gov (United States)

    2016-05-19

    1 Parametric Investigation of the Effect of Hub Pitching Moment on Blade Vortex Interaction (BVI) Noise of an Isolated Rotor Carlos Malpica...radiation. Objective The aim of this study is to investigate the sensitivity of BVI noise radiation to changes in the hub pitch moment trim state...calculations the aerodynamic loads on the blades were evaluated at azimuth intervals of 15 deg. The relatively large time (azimuth) step is

  20. Dynamically Allocated Hub in Task-Evoked Network Predicts the Vulnerable Prefrontal Locus for Contextual Memory Retrieval in Macaques.

    Directory of Open Access Journals (Sweden)

    Takahiro Osada

    2015-06-01

    Full Text Available Neuroimaging and neurophysiology have revealed that multiple areas in the prefrontal cortex (PFC are activated in a specific memory task, but severity of impairment after PFC lesions is largely different depending on which activated area is damaged. The critical relationship between lesion sites and impairments has not yet been given a clear mechanistic explanation. Although recent works proposed that a whole-brain network contains hubs that play integrative roles in cortical information processing, this framework relying on an anatomy-based structural network cannot account for the vulnerable locus for a specific task, lesioning of which would bring impairment. Here, we hypothesized that (i activated PFC areas dynamically form an ordered network centered at a task-specific "functional hub" and (ii the lesion-effective site corresponds to the "functional hub," but not to a task-invariant "structural hub." To test these hypotheses, we conducted functional magnetic resonance imaging experiments in macaques performing a temporal contextual memory task. We found that the activated areas formed a hierarchical hub-centric network based on task-evoked directed connectivity, differently from the anatomical network reflecting axonal projection patterns. Using a novel simulated-lesion method based on support vector machine, we estimated severity of impairment after lesioning of each area, which accorded well with a known dissociation in contextual memory impairment in macaques (impairment after lesioning in area 9/46d, but not in area 8Ad. The predicted severity of impairment was proportional to the network "hubness" of the virtually lesioned area in the task-evoked directed connectivity network, rather than in the anatomical network known from tracer studies. Our results suggest that PFC areas dynamically and cooperatively shape a functional hub-centric network to reallocate the lesion-effective site depending on the cognitive processes, apart from

  1. Dynamically Allocated Hub in Task-Evoked Network Predicts the Vulnerable Prefrontal Locus for Contextual Memory Retrieval in Macaques.

    Science.gov (United States)

    Osada, Takahiro; Adachi, Yusuke; Miyamoto, Kentaro; Jimura, Koji; Setsuie, Rieko; Miyashita, Yasushi

    2015-06-01

    Neuroimaging and neurophysiology have revealed that multiple areas in the prefrontal cortex (PFC) are activated in a specific memory task, but severity of impairment after PFC lesions is largely different depending on which activated area is damaged. The critical relationship between lesion sites and impairments has not yet been given a clear mechanistic explanation. Although recent works proposed that a whole-brain network contains hubs that play integrative roles in cortical information processing, this framework relying on an anatomy-based structural network cannot account for the vulnerable locus for a specific task, lesioning of which would bring impairment. Here, we hypothesized that (i) activated PFC areas dynamically form an ordered network centered at a task-specific "functional hub" and (ii) the lesion-effective site corresponds to the "functional hub," but not to a task-invariant "structural hub." To test these hypotheses, we conducted functional magnetic resonance imaging experiments in macaques performing a temporal contextual memory task. We found that the activated areas formed a hierarchical hub-centric network based on task-evoked directed connectivity, differently from the anatomical network reflecting axonal projection patterns. Using a novel simulated-lesion method based on support vector machine, we estimated severity of impairment after lesioning of each area, which accorded well with a known dissociation in contextual memory impairment in macaques (impairment after lesioning in area 9/46d, but not in area 8Ad). The predicted severity of impairment was proportional to the network "hubness" of the virtually lesioned area in the task-evoked directed connectivity network, rather than in the anatomical network known from tracer studies. Our results suggest that PFC areas dynamically and cooperatively shape a functional hub-centric network to reallocate the lesion-effective site depending on the cognitive processes, apart from static anatomical

  2. Low Melt Height Solidification of Superalloys

    Science.gov (United States)

    Montakhab, Mehdi; Bacak, Mert; Balikci, Ercan

    2016-06-01

    Effect of a reduced melt height in the directional solidification of a superalloy has been investigated by two methods: vertical Bridgman (VB) and vertical Bridgman with a submerged baffle (VBSB). The latter is a relatively new technique and provides a reduced melt height ahead of the solidifying interface. A low melt height leads to a larger primary dendrite arm spacing but a lower mushy length, melt-back transition length, and porosity. The VBSB technique yields up to 38 pct reduction in the porosity. This may improve a component's mechanical strength especially in a creep-fatigue type dynamic loading.

  3. ALMA telescope reaches new heights

    Science.gov (United States)

    2009-09-01

    of the Array Operations Site. This means surviving strong winds and temperatures between +20 and -20 Celsius whilst being able to point precisely enough that they could pick out a golf ball at a distance of 15 km, and to keep their smooth reflecting surfaces accurate to better than 25 micrometres (less than the typical thickness of a human hair). Once the transporter reached the high plateau it carried the antenna to a concrete pad - a docking station with connections for power and fibre optics - and positioned it with an accuracy of a few millimetres. The transporter is guided by a laser steering system and, just like some cars today, also has ultrasonic collision detectors. These sensors ensure the safety of the state-of-the-art antennas as the transporter drives them across what will soon be a rather crowded plateau. Ultimately, ALMA will have at least 66 antennas distributed over about 200 pads, spread over distances of up to 18.5 km and operating as a single, giant telescope. Even when ALMA is fully operational, the transporters will be used to move the antennas between pads to reconfigure the telescope for different kinds of observations. "Transporting our first antenna to the Chajnantor plateau is a epic feat which exemplifies the exciting times in which ALMA is living. Day after day, our global collaboration brings us closer to the birth of the most ambitious ground-based astronomical observatory in the world", said Thijs de Graauw, ALMA Director. This first ALMA antenna at the high site will soon be joined by others and the ALMA team looks forward to making their first observations from the Chajnantor plateau. They plan to link three antennas by early 2010, and to make the first scientific observations with ALMA in the second half of 2011. ALMA will help astronomers answer important questions about our cosmic origins. The telescope will observe the Universe using light with millimetre and submillimetre wavelengths, between infrared light and radio waves in

  4. Brokered virtual hubs for facilitating access and use of geospatial Open Data

    Science.gov (United States)

    Mazzetti, Paolo; Latre, Miguel; Kamali, Nargess; Brumana, Raffaella; Braumann, Stefan; Nativi, Stefano

    2016-04-01

    Open Data is a major trend in current information technology scenario and it is often publicised as one of the pillars of the information society in the near future. In particular, geospatial Open Data have a huge potential also for Earth Sciences, through the enablement of innovative applications and services integrating heterogeneous information. However, open does not mean usable. As it was recognized at the very beginning of the Web revolution, many different degrees of openness exist: from simple sharing in a proprietary format to advanced sharing in standard formats and including semantic information. Therefore, to fully unleash the potential of geospatial Open Data, advanced infrastructures are needed to increase the data openness degree, enhancing their usability. In October 2014, the ENERGIC OD (European NEtwork for Redistributing Geospatial Information to user Communities - Open Data) project, funded by the European Union under the Competitiveness and Innovation framework Programme (CIP), has started. In response to the EU call, the general objective of the project is to "facilitate the use of open (freely available) geographic data from different sources for the creation of innovative applications and services through the creation of Virtual Hubs". The ENERGIC OD Virtual Hubs aim to facilitate the use of geospatial Open Data by lowering and possibly removing the main barriers which hampers geo-information (GI) usage by end-users and application developers. Data and services heterogeneity is recognized as one of the major barriers to Open Data (re-)use. It imposes end-users and developers to spend a lot of effort in accessing different infrastructures and harmonizing datasets. Such heterogeneity cannot be completely removed through the adoption of standard specifications for service interfaces, metadata and data models, since different infrastructures adopt different standards to answer to specific challenges and to address specific use-cases. Thus

  5. Mixing-Height Time Series from Operational Ceilometer Aerosol-Layer Heights

    Science.gov (United States)

    Lotteraner, Christoph; Piringer, Martin

    2016-07-01

    A new method is described to derive mixing-height time series directly from aerosol-layer height data available from a Vaisala CL51 ceilometer. As complete as possible mixing-height time series are calculated by avoiding outliers, filling data gaps by linear interpolation, and smoothing. In addition, large aerosol-layer heights at night that can be interpreted as residual layers are not assigned as mixing heights. The resulting mixing-height time series, converted to an appropriate data format, can be used as input for dispersion calculations. Two case examples demonstrate in detail how the method works. The mixing heights calculated using ceilometer data are compared with values determined from radiosounding data at Vienna by applying the parcel, Heffter, and Richardson methods. The results of the parcel method, obtained from radiosonde profiles at noon, show the best fit to the ceilometer-derived mixing heights. For midnight radiosoundings, larger deviations between mixing heights from the ceilometer and those deduced from the potential temperature profiles of the soundings are found. We use data from two Vaisala CL51 ceilometers, operating in the Vienna area at an urban and rural site, respectively, during an overlapping period of about 1 year. In addition to the case studies, the calculated mixing-height time series are also statistically evaluated and compared, demonstrating that the ceilometer-based mixing height follows an expected daily and seasonal course.

  6. Mixing-Height Time Series from Operational Ceilometer Aerosol-Layer Heights

    Science.gov (United States)

    Lotteraner, Christoph; Piringer, Martin

    2016-11-01

    A new method is described to derive mixing-height time series directly from aerosol-layer height data available from a Vaisala CL51 ceilometer. As complete as possible mixing-height time series are calculated by avoiding outliers, filling data gaps by linear interpolation, and smoothing. In addition, large aerosol-layer heights at night that can be interpreted as residual layers are not assigned as mixing heights. The resulting mixing-height time series, converted to an appropriate data format, can be used as input for dispersion calculations. Two case examples demonstrate in detail how the method works. The mixing heights calculated using ceilometer data are compared with values determined from radiosounding data at Vienna by applying the parcel, Heffter, and Richardson methods. The results of the parcel method, obtained from radiosonde profiles at noon, show the best fit to the ceilometer-derived mixing heights. For midnight radiosoundings, larger deviations between mixing heights from the ceilometer and those deduced from the potential temperature profiles of the soundings are found. We use data from two Vaisala CL51 ceilometers, operating in the Vienna area at an urban and rural site, respectively, during an overlapping period of about 1 year. In addition to the case studies, the calculated mixing-height time series are also statistically evaluated and compared, demonstrating that the ceilometer-based mixing height follows an expected daily and seasonal course.

  7. Height of lumbar discs measured from radiographs compared with degeneration and height classified from MR images

    Energy Technology Data Exchange (ETDEWEB)

    Frobin, W.; Brinckmann, P. [Muenster Univ. (Germany). Inst. fuer Experimentelle Biomechanik; Kramer, M.; Hartwig, E. [Ulm Univ. (Germany). Sektion fuer Unfallchirurgische Forschung und Biomechanik

    2001-02-01

    The relation between height of lumbar discs (measured from lateral radiographic views) and disc degeneration (classified from MR images) deserves attention in view of the wide, often parallel or interchanged use of both methods. The time sequence of degenerative signs and decrease of disc height is controversial. To clarify the issue, this cross-sectional study documents the relation between disc degeneration and disc height in a selected cohort. Forty-three subjects were selected at random from a cohort examined for potential disc-related disease caused by long-term lifting and carrying. From each subject a lateral radiographic view of the lumbar spine as well as findings from an MR investigation of (in most cases) levels T12/L1 to L5/S1 were available; thus, n = 237 lumbar discs were available for measurement and classification. Disc height was measured from the radiographic views with a new protocol compensating for image distortion and permitting comparison with normal, age- and gender-appropriate disc height. Degeneration as well as disc height were classified twice from MR images by independent observers in a blinded fashion. Disc degeneration classified from MR images is not related to a measurable disc height loss in the first stage of degeneration, whereas progressive degeneration goes along with progressive loss of disc height, though with considerable interindividual variation. Loss of disc height classified from MR images is on average compatible with loss of disc height measured from radiographs. In individual discs, however, classification of height loss from MR images is imprecise. The first sign of disc degeneration (a moderate loss of nucleus signal) precedes disc height decrease. As degeneration progresses, disc height decreases. Disc height decrease and progress of degeneration, however, appear to be only loosely correlated. (orig.)

  8. PR/VI Geoid Heights (GEOID96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' geoid height grid for Puerto Rico and the Virgin Islands is distributed as a GEOID96 model. The computation used 26,000 terrestrial and marine gravity data...

  9. Principal Hawaiian Islands Geoid Heights (GEOID96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' geoid height grid for the Principal Hawaiian Islands is distributed as a GEOID96 model. The computation used 61,000 terrestrial and marine gravity data held...

  10. Height as a basis for interpersonal attraction.

    Science.gov (United States)

    Hensley, W E

    1994-01-01

    Beginning with the observation of a male-taller basis in date/mate selection, this study investigated a complementary vs. a step function in choosing a dating partner. In addition, the relative advantages or disadvantages of height were examined for both genders in the dating marketplace. Our sample of college students (N = 594) indicated that while we may use a complementary standard in hypothetical date selection, the actual height of a chosen person is more likely to be made on a step function. Second, there appears to be no dating consequences for a female in a height-related sense, but taller males do enjoy a noticeable dating advantage. Finally, there appears to be a "ceiling effect" demonstrated here for the first time; the height advantage for a male seems to diminish when he is taller than six feet. Suggestions are offered which integrate the present findings into past research.

  11. U.S. Geoid Heights (GEOID96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' geoid height grid for the conterminous United States is the GEOID96 model. The computation used about 1.8 million terrestrial and marine gravity data held in...

  12. Negation of the Self in Wuthering Heights

    Institute of Scientific and Technical Information of China (English)

    李敏

    2015-01-01

    Emily Bronte created one of the greatest novels in19th British literary history---Wuthering Heights.Through this works,the writers tries to severely criticize the feature in western civilization:negation of the self.

  13. Negation of the Self in Wuthering Heights

    Institute of Scientific and Technical Information of China (English)

    李敏

    2015-01-01

    Emily Bronte created one of the greatest novels in 19th British literary history---Wuthering Heights.Through this works,the writers tries to severely criticize the feature in western civilization: negation of the self.

  14. Challenges in Defining Tsunami Wave Heights

    Science.gov (United States)

    Dunbar, Paula; Mungov, George; Sweeney, Aaron; Stroker, Kelly; Arcos, Nicolas

    2017-08-01

    The National Oceanic and Atmospheric Administration (NOAA) National Centers for Environmental Information (NCEI) and co-located World Data Service for Geophysics maintain the global tsunami archive consisting of the historical tsunami database, imagery, and raw and processed water level data. The historical tsunami database incorporates, where available, maximum wave heights for each coastal tide gauge and deep-ocean buoy that recorded a tsunami signal. These data are important because they are used for tsunami hazard assessment, model calibration, validation, and forecast and warning. There have been ongoing discussions in the tsunami community about the correct way to measure and report these wave heights. It is important to understand how these measurements might vary depending on how the data were processed and the definition of maximum wave height. On September 16, 2015, an 8.3 M w earthquake located 48 km west of Illapel, Chile generated a tsunami that was observed all over the Pacific region. We processed the time-series water level data for 57 coastal tide gauges that recorded this tsunami and compared the maximum wave heights determined from different definitions. We also compared the maximum wave heights from the NCEI-processed data with the heights reported by the NOAA Tsunami Warning Centers. We found that in the near field different methods of determining the maximum tsunami wave heights could result in large differences due to possible instrumental clipping. We also found that the maximum peak is usually larger than the maximum amplitude (½ peak-to-trough), but the differences for the majority of the stations were definition (maximum peak or amplitude) would have validated the forecasts issued by the NOAA Tsunami Warning Centers. Since there is currently only one field in the NCEI historical tsunami database to store the maximum tsunami wave height for each tide gauge and deep-ocean buoy, NCEI will consider adding an additional field for the maximum

  15. [Fear of Heights in Primary School Children].

    Science.gov (United States)

    Huppert, D

    2016-03-01

    The life-time prevalence of visual height intolerance in adults is 28 percent, whereas in primary school children, as recently shown, it develops in 34 percent. Triggers and symptoms are similar in children and adults. A significant difference in visual height intolerance of prepubertal children compared to adults is the good prognosis with mostly spontaneous remission within a few years, possibly facilitated by repeated exposure to the triggering situations. © Georg Thieme Verlag KG Stuttgart · New York.

  16. Afsluitdijk upgrading, non typical Dutch solutions

    NARCIS (Netherlands)

    Arecco, P.; Li, Y.; Miranda Eguez, C.; Ruiz Fuentes, M.J.

    2013-01-01

    The Afsluitdijk (Enclosure Dam) is a major causeway in the Netherlands, which was constructed between 1927 and 1933, running from Den Oever on Wieringen in North Holland province, to the village of Zurich in Friesland province. The dam is 32 kilometers long and 90 m wide, with an initial height of

  17. Typicality, physiological activity and concept identification.

    NARCIS (Netherlands)

    Das-Smaal, E.A.; Swart, de J.H.

    1981-01-01

    The extent to which instances are good or poor examples of their categories (typicality) was varied in a concept identification (CI) task. Typicality was first established for the kind of artificial material traditionally used in CI tasks (experiment 1). This material was employed in a CI task

  18. Love and fear of heights: the pathophysiology and psychology of height imbalance.

    Science.gov (United States)

    Salassa, John R; Zapala, David A

    2009-01-01

    Individual psychological responses to heights vary on a continuum from acrophobia to height intolerance, height tolerance, and height enjoyment. This paper reviews the English literature and summarizes the physiologic and psychological factors that generate different responses to heights while standing still in a static or motionless environment. Perceptual cues to height arise from vision. Normal postural sway of 2 cm for peripheral objects within 3 m increases as eye-object distance increases. Postural sway >10 cm can result in a fall. A minimum of 20 minutes of peripheral retinal arc is required to detect motion. Trigonometry dictates that a 20-minute peripheral retinal arch can no longer be achieved in a standing position at an eye-object distance of >20 m. At this distance, visual cues conflict with somatosensory and vestibular inputs, resulting in variable degrees of imbalance. Co-occurring deficits in the visual, vestibular, and somatosensory systems can significantly increase height imbalance. An individual's psychological makeup, influenced by learned and genetic factors, can influence reactions to height imbalance. Enhancing peripheral vision and vestibular, proprioceptive, and haptic functions may improve height imbalance. Psychotherapy may improve the troubling subjective sensations to heights.

  19. Social inequalities in height: persisting differences today depend upon height of the parents.

    Directory of Open Access Journals (Sweden)

    Bruna Galobardes

    Full Text Available Substantial increases in height have occurred concurrently with economic development in most populations during the last century. In high-income countries, environmental exposures that can limit genetic growth potential appear to have lessened, and variation in height by socioeconomic position may have diminished. The objective of this study is to investigate inequalities in height in a cohort of children born in the early 1990s in England, and to evaluate which factors might explain any identified inequalities.12,830 children from The Avon Longitudinal Study of Parents and Children (ALSPAC, a population based cohort from birth to about 11.5 years of age, were used in this analysis. Gender- and age-specific z-scores of height at different ages were used as outcome variables. Multilevel models were used to take into account the repeated measures of height and to analyze gender- and age-specific relative changes in height from birth to 11.5 years. Maternal education was the main exposure variable used to examine socioeconomic inequalities. The roles of parental and family characteristics in explaining any observed differences between maternal education and child height were investigated. Children whose mothers had the highest education compared to those with none or a basic level of education, were 0.39 cm longer at birth (95% CI: 0.30 to 0.48. These differences persisted and at 11.5 years the height difference was 1.4 cm (95% CI: 1.07 to 1.74. Several other factors were related to offspring height, but few changed the relationship with maternal education. The one exception was mid-parental height, which fully accounted for the maternal educational differences in offspring height.In a cohort of children born in the 1990s, mothers with higher education gave birth to taller boys and girls. Although height differences were small they persisted throughout childhood. Maternal and paternal height fully explained these differences.

  20. Three Aspects of Typicality in Multiverse Cosmology

    CERN Document Server

    Azhar, Feraz

    2016-01-01

    Extracting predictions from cosmological theories that describe a multiverse, for what we are likely to observe in our domain, is crucial to establishing the validity of these theories. One way to extract such predictions is from theory-generated probability distributions that allow for selection effects---generally expressed in terms of assumptions about anthropic conditionalization and how typical we are. In this paper, I urge three lessons about typicality in multiverse settings. (i) Because it is difficult to characterize our observational situation in the multiverse, we cannot assume that we are typical (as in the 'principle of mediocrity'): nor can we ignore the issue of typicality, for it has a measurable impact on predictions for our observations. (ii) There are spectra of assumptions about both conditionalization and typicality, which lead to coincident predictions for our observations, leading to problems of confirmation in multiverse cosmology. And moreover, (iii) when one has the freedom to consid...

  1. Evaluation of proper height for squatting stool.

    Science.gov (United States)

    Jung, Hwa S; Jung, Hyung-Shik

    2008-05-01

    Many jobs and activities in people's daily lives have them in squatting postures. Jobs such as housekeeping, farming and welding require various squatting activities. It is speculated that prolonged squatting without any type of supporting stool would gradually and eventually impose musculoskeletal injuries on workers. This study aims to examine the proper height of the stool according to the position of working materials for the squatting worker. A total of 40 male and female college students and 10 female farmers participated in the experiment to find the proper stool height. Student participants were asked to sit and work in three different positions: floor level of 50 mm; ankle level of 200 mm; and knee level of 400 mm. They were then provided with stools of various heights and asked to maintain a squatting work posture. For each working position, they were asked to write down their thoughts on a preferred stool height. A Likert summated rating method as well as pairwise ranking test was applied to evaluate user preference for provided stools under conditions of different working positions. Under a similar experimental procedure, female farmers were asked to indicate their body part discomfort (BPD) on a body chart before and after performing the work. Statistical analysis showed that comparable results were found from both evaluation measures. When working position is below 50 mm, the proper stool height is 100 or should not be higher than 150 mm. When working position is 200 mm, the proper stool height is 150 mm. When working position is 400 mm, the proper stool height is 200 mm. Thus, it is strongly recommended to use proper height of stools with corresponding working position. Moreover, a wearable chair prototype was designed so that workers in a squatting posture do not have to carry and move the stool from one place to another. This stool should ultimately help to relieve physical stress and hence promote the health of squatting workers. This study sought

  2. The FUTUREVOLC Supersite's e-Infrastructure - A multidisciplinary data hub and data service for Icelandic Volcanoes

    Science.gov (United States)

    Vogfjörd, Kristín S.; Sigmundsson, Freysteinn; Sverrisson, Sverrir Th.; Sigurdsson, Sigurdur F.; Ófeigsson, Benedikt G.; Arnarsson, Ólafur S.; Kristinsson, Ingvar; Ilyinskaya, Evgenia; Oddsdóttir, Thorarna Ýr; Bergsveinsson, Sölvi Th.; Hjartansson, Kristján R.

    2014-05-01

    The FUTUREVOLC volanological supersite will establish a data hub and dataservice, where researchers, hazard managers and other stake holders can freely obtain access to multidisciplinary data and products on activity, unrest and eruptions at Icelandic volcanoes. The supersite is firmly founded on close interaction between the main Icelandic volcanological research and monitoring institutions, in coordination with expertise from European researchers participating in FUTUREVOLC. The hub is located at the Icelandic Meteorological Office (IMO), an institution responsible for monitoring and archiving data on all natural hazards in Iceland and, which also has a mandate as the state volcano observatory. This association will ensure a long-term sustainable data service. The data accessible at the hub include in-situ and space-based observations, products and models from all the relevant disciplines contributing to volcanological research and local as well as cross-border hazard management, i.e. Earth sciences, atmospheric science, hydrology, remote sensing and space science. Access to the data will be in compliance with the access policy of the GEO (Group on Earth Observations), providing registered users with easy and timely access to data and products of documented quality. This commitment has already led to the acceptance of FUTUREVOLC as a permanent geohazard supersite by CEOS (Committee on Earth Observation Satellites), which will ensure access to additional satellite data and products on Icelandic volcanoes. To facilitate services to seismological data at the supersite hub, the IMO is reconstructing its existing data base and utilizing the SeisComp3 software to manage waveform and parameter data. The accompanying ArcLink component will be used to provide access to event data and waveforms. Access to GPS data will be provided by the GSAC web service which has been installed at the IMO through collaboration with UNAVCO. If appropriate, the format and data base

  3. Prediction of height from knee height in children with cerebral palsy and non-disabled children.

    Science.gov (United States)

    Bell, Kristie L; Davies, Peter S W

    2006-01-01

    Measurement of height or length is essential in the assessment of nutritional status. In some conditions, for example cerebral palsy (CP), such measurements may be difficult or impossible. Proxy measurements such as knee height have been used to predict height in such cases. We have evaluated two equations in the literature that predict stature from knee height in a group of 17 children with CP and 20 non-disabled children. The two equations performed well on average in the non-disabled children, with the mean predicted height being within 1% of the mean measured height. Nevertheless, the limits of agreement were relatively large. This was also the case for the children with CP. Thus the equations may be accurate at the group level; however they may lead to unacceptable error at the individual level..

  4. Lazy Updating of hubs can enable more realistic models by speeding up stochastic simulations

    Energy Technology Data Exchange (ETDEWEB)

    Ehlert, Kurt; Loewe, Laurence, E-mail: loewe@wisc.edu [Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53706 (United States); Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin 53715 (United States)

    2014-11-28

    To respect the nature of discrete parts in a system, stochastic simulation algorithms (SSAs) must update for each action (i) all part counts and (ii) each action's probability of occurring next and its timing. This makes it expensive to simulate biological networks with well-connected “hubs” such as ATP that affect many actions. Temperature and volume also affect many actions and may be changed significantly in small steps by the network itself during fever and cell growth, respectively. Such trends matter for evolutionary questions, as cell volume determines doubling times and fever may affect survival, both key traits for biological evolution. Yet simulations often ignore such trends and assume constant environments to avoid many costly probability updates. Such computational convenience precludes analyses of important aspects of evolution. Here we present “Lazy Updating,” an add-on for SSAs designed to reduce the cost of simulating hubs. When a hub changes, Lazy Updating postpones all probability updates for reactions depending on this hub, until a threshold is crossed. Speedup is substantial if most computing time is spent on such updates. We implemented Lazy Updating for the Sorting Direct Method and it is easily integrated into other SSAs such as Gillespie's Direct Method or the Next Reaction Method. Testing on several toy models and a cellular metabolism model showed >10× faster simulations for its use-cases—with a small loss of accuracy. Thus we see Lazy Updating as a valuable tool for some special but important simulation problems that are difficult to address efficiently otherwise.

  5. Interpatch foraging in honeybees-rational decision making at secondary hubs based upon time and motivation.

    Science.gov (United States)

    Najera, Daniel A; McCullough, Erin L; Jander, Rudolf

    2012-11-01

    For honeybees, Apis mellifera, the hive has been well known to function as a primary decision-making hub, a place from which foragers decide among various directions, distances, and times of day to forage efficiently. Whether foraging honeybees can make similarly complex navigational decisions from locations away from the hive is unknown. To examine whether or not such secondary decision-making hubs exist, we trained bees to forage at four different locations. Specifically, we trained honeybees to first forage to a distal site "CT" 100 m away from the hive; if food was present, they fed and then chose to go home. If food was not present, the honeybees were trained to forage to three auxiliary sites, each at a different time of the day: A in the morning, B at noon, and C in the afternoon. The foragers learned to check site CT for food first and then efficiently depart to the correct location based upon the time of day if there was no food at site CT. Thus, the honeybees were able to cognitively map motivation, time, and five different locations (Hive, CT, A, B, and C) in two spatial dimensions; these are the contents of the cognitive map used by the honeybees here. While at site CT, we verified that the honeybees could choose between 4 different directions (to A, B, C, and the Hive) and thus label it as a secondary decision-making hub. The observed decision making uncovered here is inferred to constitute genuine logical operations, involving a branched structure, based upon the premises of motivational state, and spatiotemporal knowledge.

  6. The Roles of Altitude and Fear in the Perception of Height

    Science.gov (United States)

    Stefanucci, Jeanine K.; Proffitt, Dennis R.

    2009-01-01

    Previous research on perceiving spatial layout has found that people often exhibit normative biases in their perception of the environment. For instance, slant is typically overestimated and distance is usually underestimated. Surprisingly, however, the perception of height has rarely been studied. The present experiments examined the perception…

  7. Rational cutting height for large cutting height fully mechanized top-coal caving

    Institute of Scientific and Technical Information of China (English)

    Huang Bingxiang; Li Hongtao; Liu Changyou; Xing Shijun; Xue Weichao

    2011-01-01

    Large cutting height fully mechanized top-coal caving is a new mining method that improves recovery ratio and single-pass production.It also allows safe and efficient mining.A rational cutting height is one key parameter of this technique.Numerical simulation and a granular-media model experiment were used to analyze the effect of cutting height on the rock pressure of a fully mechanized top-coal caving work face.The recovery ratio was also studied.As the cutting height increases the top-coal thickness is reduced.Changing the ratio of cutting to drawing height intensifies the face pressure and the top-coal shattering.A maximum cutting height exists under a given set of conditions due to issues with surrounding rock-mass control.An increase in cutting height makes the top-coal cave better and the recovery ratio when drawing top-coal is then improved.A method of adjusting the face rock pressure is presented.Changing the cutting to drawing height ratio is the technique used to control face rock pressure.The recovery ratio when cutting coal exceeds that when caving top-coal so the face recovery ratio may be improved by over sizing the cutting height and increasing the top-coal drawing ratio.An optimum ratio of cutting to drawing height exists that maximizes the face recovery ratio.A rational cutting height is determined by comprehensively considering the surrounding rock-mass control and the recovery ratio.At the same time increasing the cutting height can improve single pass mining during fully mechanized top-coal caving.

  8. Hubs and Authorities of the English Premier League for 2010-2011

    OpenAIRE

    Leznik, Michael

    2013-01-01

    In this work author applies well known web search algorithm Hyperlink - Induced Topic Search (HITS) to problem of ranking football teams in English Premier League (EPL). The algorithm allows the ranking of the teams using the notions of hubs and authorities well known for ranking pages in the World Wide Web. Results of the games introduced as a graph where losing team 'gives a link' to a winning team and, if draw registered both team give links to each other. In case of a win link is weighted...

  9. Home health monitoring – EyKos HealthHub (product design concept)

    OpenAIRE

    Phillips, Mark; Dulake, Nick; Willox, Matt; Gwilt, Ian; Craig, Claire; Auton, Kevin

    2015-01-01

    This work focused on creating a product design concept for a home health monitoring system, known as EyKos HealthHub, which is intended to be a ‘crossover product’ in the emerging medical/consumer product space. Working collaboratively with Aseptika Ltd, the team carried out product concept design and interaction design for the EyKos system, and undertook further design and prototyping work to create an object for use in research. Aseptika is carrying out technical development of this project...

  10. Unveiling Exception Handling Bug Hazards in Android Based on GitHub and Google Code Issues

    OpenAIRE

    Coelho, R.; L. Almeida; Gousios, G.; Van Deursen, A.

    2015-01-01

    This paper reports on a study mining the exception stack traces included in 159,048 issues reported on Android projects hosted in GitHub (482 projects) and Google Code (157 projects). The goal of this study is to investigate whether stack trace information can reveal bug hazards related to exception handling code that may lead to a decrease in application robustness. Overall 6,005 exception stack traces were extracted, and subjected to source code and bytecode analysis. The outcomes of this s...

  11. Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

    Directory of Open Access Journals (Sweden)

    Luo X

    2017-07-01

    Full Text Available Xiaoping Luo,1,2 Linghong Guo,1 Xi-Jian Dai,3 Qinglai Wang,2 Wenzhong Zhu,2 Xinjun Miao,2 Honghan Gong1 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 2Department of Radiology, Wenzhou Chinese Medicine Hospital, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People’s Republic of China Objective: To explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features.Materials and methods: Twenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years and 24 age- and education-matched male healthy controls (mean age, 50.29±8.92 years were recruited. The alcohol use disorders identification test and the severity of alcohol dependence questionnaire (SADQ were administered to assess the severity of alcohol craving. Voxelwise degree centrality approach was used to assess the abnormal intrinsic functional hubs features in alcohol dependence. Simple linear regression analysis was performed to investigate the relationships between the clinical features and abnormal intrinsic functional hubs.Results: Compared with healthy controls, alcohol dependence subjects exhibited significantly different degree centrality values in widespread left lateralization brain areas, including higher degree centrality values in the left precentral gyrus (BA 6, right hippocampus (BA 35, 36, and left orbitofrontal cortex (BA 11 and lower degree centrality values in the left cerebellum posterior lobe, bilateral secondary visual network (BA 18, and left precuneus (BA 7, 19. SADQ revealed a negative linear correlation with the degree centrality value in the left precentral gyrus (R2=0.296, P=0.006.Conclusion: The specific abnormal intrinsic functional hubs appear

  12. The difference between the Weil height and the canonical height on elliptic curves

    Science.gov (United States)

    Silverman, Joseph H.

    1990-10-01

    Estimates for the difference of the Weil height and the canonical height of points on elliptic curves are used for many purposes, both theoretical and computational. In this note we give an explicit estimate for this difference in terms of the j-invariant and discriminant of the elliptic curve. The method of proof, suggested by Serge Lang, is to use the decomposition of the canonical height into a sum of local heights. We illustrate one use for our estimate by computing generators for the Mordell-Weil group in three examples.

  13. Some typical solid propellant rocket motors

    NARCIS (Netherlands)

    Zandbergen, B.T.C.

    2013-01-01

    Typical Solid Propellant Rocket Motors (shortly referred to as Solid Rocket Motors; SRM's) are described with the purpose to form a database, which allows for comparative analysis and applications in practical SRM engineering.

  14. Some typical solid propellant rocket motors

    NARCIS (Netherlands)

    Zandbergen, B.T.C.

    2013-01-01

    Typical Solid Propellant Rocket Motors (shortly referred to as Solid Rocket Motors; SRM's) are described with the purpose to form a database, which allows for comparative analysis and applications in practical SRM engineering.

  15. Real-Time Monitoring and Fault Diagnosis of a Low Power Hub Motor Using Feedforward Neural Network

    Directory of Open Access Journals (Sweden)

    Mehmet Şimşir

    2016-01-01

    Full Text Available Low power hub motors are widely used in electromechanical systems such as electrical bicycles and solar vehicles due to their robustness and compact structure. Such systems driven by hub motors (in wheel motors encounter previously defined and undefined faults under operation. It may inevitably lead to the interruption of the electromechanical system operation; hence, economic losses take place at certain times. Therefore, in order to maintain system operation sustainability, the motor should be precisely monitored and the faults are diagnosed considering various significant motor parameters. In this study, the artificial feedforward backpropagation neural network approach is proposed to real-time monitor and diagnose the faults of the hub motor by measuring seven main system parameters. So as to construct a necessary model, we trained the model, using a data set consisting of 4160 samples where each has 7 parameters, by the MATLAB environment until the best model is obtained. The results are encouraging and meaningful for the specific motor and the developed model may be applicable to other types of hub motors. The prosperous model of the whole system was embedded into Arduino Due microcontroller card and the mobile real-time monitoring and fault diagnosis system prototype for hub motor was designed and manufactured.

  16. Design and Analysis of a Novel Speed-Changing Wheel Hub with an Integrated Electric Motor for Electric Bicycles

    Directory of Open Access Journals (Sweden)

    Yi-Chang Wu

    2013-01-01

    Full Text Available The aim of this paper is to present an innovative electromechanical device which integrates a brushless DC (BLDC hub motor with a speed-changing wheel hub stored on the rear wheel of an electric bicycle. It combines a power source and a speed-changing mechanism to simultaneously provide functions of power generation and transmission for electric bicycles. As part of the proposed integrated device, the wheel hub consists of a basic planetary gear train providing three forward speeds including a low-speed gear, a direct drive, and a high-speed gear. Each gear is manually controlled by the shift control sleeve to selectively engage or disengage four pawl-and-ratchet clutches based on its clutching sequence table. The number of gear teeth of each gear element of the wheel hub is synthesized. The BLDC hub motor is an exterior-rotor-type permanent-magnet synchronous motor. Two-dimensional finite-element analysis (FEA software is employed to facilitate the motor design and performance analysis. An analysis of the power transmission path at each gear is provided to verify the validity of the proposed design. The results of this work are beneficial to the embodiment, design, and development of novel electromechanical devices for the power and transmission systems of electric bicycles.

  17. Experiences of ZAMG on mixing height determination

    Energy Technology Data Exchange (ETDEWEB)

    Piringer, M. [Zentralanstalt fuer Meteorologie und Geodynamik, ZAMG, Vienna (Austria)

    1997-10-01

    Temperature inversions in the boundary layer occur quite often, esp. in mountainous terrain by which Austria is covered to a large extent, and can lead to enhanced pollution at the surface because the air volume available for dilution is then vertically limited. The Department of Environmental Meteorology of ZAMG therefore set up several field programs in the past to study such conditions at a variety of sites in Austria, using tethersondes and Sodars. Early investigations aimed at comparing Sodar echo profiles to the tethersonde temperature profiles to derive mixing heights from the Sodar echo structure. More recently, evolving from KONGEX, the `convective boundary layer experiment`, mixing heights calculated for Vienna by the OML model were compared to those derived from radiosonde and tethersonde potential temperature profiles. Results of these investigations will be presented, focussing on the problems when using the different methods. New efforts to derive mixing heights from data were also undertaken and are discussed separately. (au)

  18. Height, Relationship Satisfaction, Jealousy, and Mate Retention

    Directory of Open Access Journals (Sweden)

    Gayle Brewer

    2009-07-01

    Full Text Available Male height is associated with high mate value. In particular, tall men are perceived as more attractive, dominant and of a higher status than shorter rivals, resulting in a greater lifetime reproductive success. Female infidelity and relationship dissolution may therefore present a greater risk to short men. It was predicted that tall men would report greater relationship satisfaction and lower jealousy and mate retention behavior than short men. Ninety eight heterosexual men in a current romantic relationship completed a questionnaire. Both linear and quadratic relationships were found between male height and relationship satisfaction, cognitive and behavioral jealousy. Tall men reported greater relationship satisfaction and lower levels of cognitive or behavioral jealousy than short men. In addition, linear and quadratic relationships were found between male height and a number of mate retention behaviors. Tall and short men engaged in different mate retention behaviors. These findings are consistent with previous research conducted in this area detailing the greater attractiveness of tall men.

  19. What is controlling the fragmentation process in the Infrared Dark Cloud G14.225-0.506? Differet level of fragmentation in twin hubs

    CERN Document Server

    Busquet, G; Palau, A; Liu, H B; Zhang, Q; Girart, J M; de Gregorio-Monsalvo, I; Pillai, T; Anglada, G; Ho, P T P

    2016-01-01

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225-0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 microns obtained with APEX and CSO telescopes. The large scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 microns and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be respon...

  20. Evidence of inbreeding depression on human height.

    Directory of Open Access Journals (Sweden)

    Ruth McQuillan

    Full Text Available Stature is a classical and highly heritable complex trait, with 80%-90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS have successfully identified many common additive variants influencing human height; however, little attention has been given to the potential role of recessive genetic effects. Here, we investigated genome-wide recessive effects by an analysis of inbreeding depression on adult height in over 35,000 people from 21 different population samples. We found a highly significant inverse association between height and genome-wide homozygosity, equivalent to a height reduction of up to 3 cm in the offspring of first cousins compared with the offspring of unrelated individuals, an effect which remained after controlling for the effects of socio-economic status, an important confounder (χ(2 = 83.89, df = 1; p = 5.2 × 10(-20. There was, however, a high degree of heterogeneity among populations: whereas the direction of the effect was consistent across most population samples, the effect size differed significantly among populations. It is likely that this reflects true biological heterogeneity: whether or not an effect can be observed will depend on both the variance in homozygosity in the population and the chance inheritance of individual recessive genotypes. These results predict that multiple, rare, recessive variants influence human height. Although this exploratory work focuses on height alone, the methodology developed is generally applicable to heritable quantitative traits (QT, paving the way for an investigation into inbreeding effects, and therefore genetic architecture, on a range of QT of biomedical importance.

  1. Adult height, dietary patterns, and healthy aging.

    Science.gov (United States)

    Ma, Wenjie; Hagan, Kaitlin A; Heianza, Yoriko; Sun, Qi; Rimm, Eric B; Qi, Lu

    2017-08-01

    Background: Adult height has shown directionally diverse associations with several age-related disorders, including cardiovascular disease, cancer, decline in cognitive function, and mortality.Objective: We investigated the associations of adult height with healthy aging measured by a full spectrum of health outcomes, including incidence of chronic diseases, memory, physical functioning, and mental health, among populations who have survived to older age, and whether lifestyle factors modified such relations.Design: We included 52,135 women (mean age: 44.2 y) from the Nurses' Health Study without chronic diseases in 1980 and whose health status was available in 2012. Healthy aging was defined as being free of 11 major chronic diseases and having no reported impairment of subjective memory, physical impairment, or mental health limitations.Results: Of all eligible study participants, 6877 (13.2%) were classified as healthy agers. After adjustment for demographic and lifestyle factors, we observed an 8% (95% CI: 6%, 11%) decrease in the odds of healthy aging per SD (0.062 m) increase in height. Compared with the lowest category of height (≤1.57 m), the OR of achieving healthy aging in the highest category (≥1.70 m) was 0.80 (95% CI: 0.73, 0.87; P-trend aging (P-interaction = 0.005), and among the individual dietary factors characterizing the prudent dietary pattern, fruit and vegetable intake showed the strongest effect modification (P-interaction = 0.01). The association of greater height with reduced odds of healthy aging appeared to be more evident among women with higher adherence to the prudent dietary pattern rich in vegetable and fruit intake.Conclusions: Greater height was associated with a modest decrease in the likelihood of healthy aging. A prudent diet rich in fruit and vegetables might modify the relation. © 2017 American Society for Nutrition.

  2. Prediction and typicality in multiverse cosmology

    Science.gov (United States)

    Azhar, Feraz

    2014-02-01

    In the absence of a fundamental theory that precisely predicts values for observable parameters, anthropic reasoning attempts to constrain probability distributions over those parameters in order to facilitate the extraction of testable predictions. The utility of this approach has been vigorously debated of late, particularly in light of theories that claim we live in a multiverse, where parameters may take differing values in regions lying outside our observable horizon. Within this cosmological framework, we investigate the efficacy of top-down anthropic reasoning based on the weak anthropic principle. We argue contrary to recent claims that it is not clear one can either dispense with notions of typicality altogether or presume typicality, in comparing resulting probability distributions with observations. We show in a concrete, top-down setting related to dark matter, that assumptions about typicality can dramatically affect predictions, thereby providing a guide to how errors in reasoning regarding typicality translate to errors in the assessment of predictive power. We conjecture that this dependence on typicality is an integral feature of anthropic reasoning in broader cosmological contexts, and argue in favour of the explicit inclusion of measures of typicality in schemes invoking anthropic reasoning, with a view to extracting predictions from multiverse scenarios.

  3. The mental space of pitch height.

    Science.gov (United States)

    Rusconi, Elena; Kwan, Bonnie; Giordano, Bruno; Umiltà, Carlo; Butterworth, Brian

    2005-12-01

    Through stimulus-response compatibility we tested whether sound frequency (pitch height) elicits a mental spatial representation. Musically untrained and, mostly, trained participants were shown a stimulus-response compatibility effect (Spatial-Musical Association of Response Codes or SMARC effect). When response alternatives were either vertically or horizontally aligned, performance was better when the lower (or leftward) button had to be pressed in response to a low sound and the upper (or rightward) button had to be pressed in response to a high sound, even when pitch height was irrelevant to the task.

  4. What is typical is good: the influence of face typicality on perceived trustworthiness.

    Science.gov (United States)

    Sofer, Carmel; Dotsch, Ron; Wigboldus, Daniel H J; Todorov, Alexander

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality's influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness judgments. Here, we argue that face typicality is an important factor for social perception because it affects trustworthiness judgments, which approximate the basic evaluation of faces. This effect has been overlooked because trustworthiness and attractiveness judgments have a high level of shared variance for most face samples. We show that for a continuum of faces that vary on a typicality-attractiveness dimension, trustworthiness judgments peak around the typical face. In contrast, perceived attractiveness increases monotonically past the typical face, as faces become more like the most attractive face. These findings suggest that face typicality is an important determinant of face evaluation.

  5. How typical are 'typical' tremor characteristics? : Sensitivity and specificity of five tremor phenomena

    NARCIS (Netherlands)

    van der Stouwe, A. M. M.; Elting, J. W.; van der Hoeven, J. H.; van Laar, T.; Leenders, K. L.; Maurits, N. M.; Tijssen, M. Aj.

    2016-01-01

    Introduction: Distinguishing between different tremor disorders can be challenging. Some tremor disorders are thought to have typical tremor characteristics: the current study aims to provide sensitivity and specificity for five 'typical' tremor phenomena. Methods: Retrospectively, we examined 210 t

  6. Reviewing the Justice and Security Hub Modality as Piloted in Liberia

    Directory of Open Access Journals (Sweden)

    Rory Keane

    2012-11-01

    Full Text Available ‘The Republic of Bangui’ or ‘the Republic of Monrovia’ are phrases we sometimes hear from practitioners to describe post conflict countries where very few services exist outside the capital city. This is especially the case for security – the critical public good in post conflict countries. In response to the need to bring security services closer to the citizens who often need them most, the Government of Liberia and the United Nations are piloting a new approach financed by the UN Peacebuilding Fund (PBF – the so-called ‘Justice and Security Hubs’. The donor community and the United Nations are watching closely. If this works, there is indication from UN officials that the model could potentially be replicated in other settings such as the East of the Democratic Republic of the Congo (DRC, Haiti and the northern states of South Sudan. If the hub concept is capable of being adapted and successful elsewhere, the United Nations will not only have added a new instrument to its peacekeeping toolkit but will also firmly demonstrate how the UN Peacebuilding Fund can in essence be catalytic in fostering long-term and comprehensive approaches to peacebuilding. This practice note outlines the process of developing and constructing the first hub in Liberia, which is due to be partly operational by the end of 2012, and provides a prognosis on its chances for success.

  7. Of Hubs and Hinterlands: Cyprus as an Insular Space of Overlapping Diasporas

    Directory of Open Access Journals (Sweden)

    Russell King

    2012-05-01

    Full Text Available This paper uses the metaphor of diasporic hubs and hinterlands to document and analyse the various diasporic formations that overlap and encounter each other on the divided island of Cyprus. After a review of the various ways that islands interface with migration processes and some essential historical and statistical background on Cyprus and its population, the paper considers a number of migrations/diasporas that are based on or affect the island. They include the emigration from the diasporic hub of Cyprus during the 1950s-1970s; return migration, both of the original emigrants and their descendants; the British military/colonial settlement of Cyprus; retirees and ‘lifestyle migrants’; and various categories of recent immigrants, for whom Cyprus is a diasporic hinterland. We draw both similarities and differences between migratory dynamics in the northern, Turkish Cypriot part of the island and the southern, Greek Cypriot part. In the final part of the paper we describe recent fieldwork on various spaces of inter-diasporic encounter in Cyprus.

  8. EXPANSION OF UNIVERSITY EDUCATION, GRADUATE UNEMPLOYMENT AND THE KNOWLEDGE HUB IN SRI LANKA

    Directory of Open Access Journals (Sweden)

    Gamini Samaranayake

    2016-04-01

    Full Text Available The main objective of this paper is to examine the nexus between the existing university education system and graduate unemployment, and to explore the responses of successive governments to address this issue. It also examines the viability and potential of the knowledge hub as a solution to graduate unemployment. Towards this end, it argues that the solution to graduate employment lies in implementing structural changes that are concurrent to changes that are taking place at the international level in higher education. It illustrates, with the use of relevant sources, the pressing issue of graduate un- and underemployment, and identifies the mismatch between skills and requirements as a major factor contributing to intensify the crisis. It observes that strategies such as training unemployed graduates to enable them to acquire the competencies needed for the modern work place, developing systems to link them to the world of work, re-structuring the university system such that it is more concerned with quality and relevance rather than the width of knowledge imparted, and introducing job-oriented programmes could partially address this issue. It also identifies the proposal to establish a knowledge hub in Sri Lanka as constituting a long term and sustainable strategy not only to mitigate the effects of graduate un- and underemployment, but also to facilitate a lucrative source of revenue for the country.

  9. Unveiling the Early-Stage Anatomy of a Protocluster Hub with ALMA

    CERN Document Server

    Henshaw, J D; Longmore, S N; Caselli, P; Pineda, J E; Avison, A; Barnes, A T; Tan, J C; Fontani, F

    2016-01-01

    High-mass stars shape the interstellar medium in galaxies, and yet, largely because the initial conditions are poorly constrained, we do not know how they form. One possibility is that high-mass stars and star clusters form at the junction of filamentary networks, referred to as "hubs". In this letter we present the complex anatomy of a protocluster hub within an Infrared Dark Cloud (IRDC), G035.39-00.33, believed to be in an early phase of its evolution. We use high-angular resolution ($\\{\\theta_{\\rm maj}, \\theta_{\\rm min}\\}=\\{1.''4, 0.''8\\}\\sim\\{0.02\\,{\\rm pc}, 0.01\\,{\\rm pc}\\}$) and high-sensitivity ($0.2$ mJy beam$^{-1}$; $\\sim0.2$ M$_{\\odot}$) 1.07 mm dust continuum observations from the Atacama Large Millimeter Array (ALMA) to identify a network of narrow, $0.028\\,\\pm\\,0.005$ pc wide, filamentary structures. These are a factor of $\\gtrsim3$ narrower than the proposed "quasi-universal" $\\sim0.1$ pc width of interstellar filaments. Additionally, 28 compact objects are reported, spanning a mass range $0.3\\...

  10. Bottlenecks and hubs in inferred networks are important for virulence in Salmonella typhimurium.

    Science.gov (United States)

    McDermott, Jason E; Taylor, Ronald C; Yoon, Hyunjin; Heffron, Fred

    2009-02-01

    Recent advances in experimental methods have provided sufficient data to consider systems as large networks of interconnected components. High-throughput determination of protein-protein interaction networks has led to the observation that topological bottlenecks, proteins defined by high centrality in the network, are enriched in proteins with systems-level phenotypes such as essentiality. Global transcriptional profiling by microarray analysis has been used extensively to characterize systems, for example, examining cellular response to environmental conditions and effects of genetic mutations. These transcriptomic datasets have been used to infer regulatory and functional relationship networks based on co-regulation. We use the context likelihood of relatedness (CLR) method to infer networks from two datasets gathered from the pathogen Salmonella typhimurium: one under a range of environmental culture conditions and the other from deletions of 15 regulators found to be essential in virulence. Bottleneck and hub genes were identified from these inferred networks, and we show for the first time that these genes are significantly more likely to be essential for virulence than their non-bottleneck or non-hub counterparts. Networks generated using simple similarity metrics (correlation and mutual information) did not display this behavior. Overall, this study demonstrates that topology of networks inferred from global transcriptional profiles provides information about the systems-level roles of bottleneck genes. Analysis of the differences between the two CLR-derived networks suggests that the bottleneck nodes are either mediators of transitions between system states or sentinels that reflect the dynamics of these transitions.

  11. Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.

    Directory of Open Access Journals (Sweden)

    Stefano Luccioli

    2014-09-01

    Full Text Available It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity.

  12. Passivity-based control with collision avoidance for a hub-beam spacecraft

    Science.gov (United States)

    Wen, Hao; Chen, Ti; Jin, Dongping; Hu, Haiyan

    2017-01-01

    For the application of robotically assembling large space structures, a feedback control law is synthesized for transitional and rotational maneuvers of a 'tug' spacecraft in order to transport a flexible element to a desired position without colliding with other space bodies. The flexible element is treated as a long beam clamped to the 'tug' spacecraft modelled as a rigid hub. First, the physical property of passivity of Euler-Lagrange system is exploited to design the position and attitude controllers by taking a simpler obstacle-free control problem into account. To reduce sensing and actuating requirements, the vibration modes of the beam appendage are supposed to be not directly measured and actuated on. Besides, the requirements of measuring velocities are removed with the aid of a dynamic extension technique. Second, the bounding boxes in the form of super-quadric surfaces are exploited to enclose the maximal extents of the obstacles and the hub-beam spacecraft. The collision avoidance between bounding boxes is achieved by applying additional repulsive force and torque to the spacecraft based on the method of artificial potential field. Finally, the effectiveness of proposed control scheme is numerically demonstrated via case studies.

  13. Partial synchronization in networks of non-linearly coupled oscillators: The Deserter Hubs Model

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Celso, E-mail: cbnfreitas@gmail.com; Macau, Elbert, E-mail: elbert.macau@inpe.br [Associate Laboratory for Computing and Applied Mathematics - LAC, Brazilian National Institute for Space Research - INPE (Brazil); Pikovsky, Arkady, E-mail: pikovsky@uni-potsdam.de [Department of Physics and Astronomy, University of Potsdam, Germany and Department of Control Theory, Nizhni Novgorod State University, Gagarin Av. 23, 606950, Nizhni Novgorod (Russian Federation)

    2015-04-15

    We study the Deserter Hubs Model: a Kuramoto-like model of coupled identical phase oscillators on a network, where attractive and repulsive couplings are balanced dynamically due to nonlinearity of interactions. Under weak force, an oscillator tends to follow the phase of its neighbors, but if an oscillator is compelled to follow its peers by a sufficient large number of cohesive neighbors, then it actually starts to act in the opposite manner, i.e., in anti-phase with the majority. Analytic results yield that if the repulsion parameter is small enough in comparison with the degree of the maximum hub, then the full synchronization state is locally stable. Numerical experiments are performed to explore the model beyond this threshold, where the overall cohesion is lost. We report in detail partially synchronous dynamical regimes, like stationary phase-locking, multistability, periodic and chaotic states. Via statistical analysis of different network organizations like tree, scale-free, and random ones, we found a measure allowing one to predict relative abundance of partially synchronous stationary states in comparison to time-dependent ones.

  14. Current Status of Mammals and Reptiles at Hub Dam Area, Sindh / Balochistan, Pakistan

    Directory of Open Access Journals (Sweden)

    Abeda Begum

    2013-12-01

    Full Text Available During the present study in 2012, a total of twenty four mammalian species were recorded belonging to 5 orders and 10 families; out of these, 8 species are less common, 2 species are rare, while 14 species are common in Hub Dam area. Twenty five reptilian species belonging to 3 orders and 12 families were also recorded from the area. Three species of mammalian Urial (Ovis vignei, Chinkara/Indian Gazelle (Gazella bennettii and Jungle Cat (Felis chaus, one reptilian species Common Krait (Bungarus caeruleus were recorded as rare from the study area during 2012. During the present study, nine mammalian species Wild Goat/Sindh Ibex (Capra aegagrus, Urial (Ovis vignei, Chinkara/Indian Gazelle (Gazella bennettii, Indian Hedgehog (Paraechinus micropus, Cape Hare (Lepus capensis, Little Indian Field Mouse (Mus booduga, House Shrew (Sorex thibetanus, Balochistan Gerbil (Gerbillus nanus and Indian Gerbil (Tatera indica and two reptilian Warty Rock Gecko (Cyrtodactylus kachhensis kachhensis and Banded Dwarf Gecko (Tropiocolotes helenae were recorded from the area. As regards threats to mammals and reptiles, these are affected by disturbance. Efforts are being made to conserve the important mammals and reptiles particularly in the protected area especially at Hub Dam.

  15. Study on rigid-flexible coupling dynamics of hub-plate system

    Institute of Scientific and Technical Information of China (English)

    ZHAO Feiyun; XIE Yongcheng; ZHANG Ming; HE Yinbiao

    2007-01-01

    Dynamic modeling of a rotating flexible hubplate system is investigated by using Jourdain's variation principle in which the finite element method (FEM) is used as discretization method for a flexible plate. Different from the previous modeling of a plate with a prescribed large overall motion, the coupling between large overall motion of the system and elastic deformation of the flexible plate is taken into account in the proposed coupling model. The quadratic terms are included in the strain-displacement expression,such that the dynamic stiffening terms are included. Simulation of a rotating hub-plate system indicates that the linear model based on linear strain-displacement assumption may lead to erroneous results in the case of high rotation speed. Conservation of energy verifies the validity of the proposed model. Furthermore, frequency analysis of a hub-plate system shows the difference between the frequencies of the system with free and prescribed large overall motion, and parameter analysis of the system reveals the coupling characteristics of the rotational motion and the deformation.

  16. Aspects of transport transit hubs construction management in coordination with object lifecycle projecting

    Directory of Open Access Journals (Sweden)

    Danilina Nina

    2016-01-01

    Full Text Available The article involves the results of the research in the field of the initial phase in the project of the object lifecycle for urban public transportation transit hubs (TTH. The main purpose is to provide definition and justification of area parameters for spatial solution of a hub with consideration of its construction viability and sustainability of urban development. In the article there are presented the results of analytical studies of the data available in the approved Planning documentation for TTH objects listed in the short-term program of TTH construction in Moscow. The point of interest was to obtain correlations between the total area of TTH area, areas of commercial and technological use and passenger traffic value in order to define territory balance providing request from city authorities and private investors for construction project management. Also, there is presented the theoretical model as an evaluation guide that allows evaluating not only the demand of a city and its population in the development of TTH territory but also and especially the requirements for placing commercial areas inside TTH.

  17. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans.

    Science.gov (United States)

    Macosko, Evan Z; Pokala, Navin; Feinberg, Evan H; Chalasani, Sreekanth H; Butcher, Rebecca A; Clardy, Jon; Bargmann, Cornelia I

    2009-04-30

    Innate social behaviours emerge from neuronal circuits that interpret sensory information on the basis of an individual's own genotype, sex and experience. The regulated aggregation behaviour of the nematode Caenorhabditis elegans, a simple animal with only 302 neurons, is an attractive system to analyse these circuits. Wild social strains of C. elegans aggregate in the presence of specific sensory cues, but solitary strains do not. Here we identify the RMG inter/motor neuron as the hub of a regulated circuit that controls aggregation and related behaviours. RMG is the central site of action of the neuropeptide receptor gene npr-1, which distinguishes solitary strains (high npr-1 activity) from wild social strains (low npr-1 activity); high RMG activity is essential for all aspects of social behaviour. Anatomical gap junctions connect RMG to several classes of sensory neurons known to promote aggregation, and to ASK sensory neurons, which are implicated in male attraction to hermaphrodite pheromones. We find that ASK neurons respond directly to pheromones, and that high RMG activity enhances ASK responses in social strains, causing hermaphrodite attraction to pheromones at concentrations that repel solitary hermaphrodites. The coordination of social behaviours by RMG suggests an anatomical hub-and-spoke model for sensory integration in aggregation, and points to functions for related circuit motifs in the C. elegans wiring diagram.

  18. What is typical is good: The influence of face typicality on perceived trustworthiness

    NARCIS (Netherlands)

    Sofer, C.; Dotsch, R.; Wigboldus, D.H.J.; Todorov, A.T.

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality's influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness

  19. DIGITAL VIDEO BROADCAST RETURN CHANNEL VIA SATELLITE (DVB-RCS HUB FOR SATELLITE BASED E-LEARNING

    Directory of Open Access Journals (Sweden)

    N.G.Vasantha Kumar

    2011-02-01

    Full Text Available This paper discusses in-house designed and developed scale-down DVB-RCS hub along with the performance of the realized hub. This development is intended to support the Satellite Based e-Learning initiative in India. The scale-down DVB-RCS HUB is implemented around a single PC with other subsystems making it very cost effective and unique of its kind. This realization will drastically reduce the total cost of Satellite based Education Networks as very low cost commercially available Satellite Interactive Terminals (SITs complying to open standard could be used at remote locations. The system is successfully tested to work with a commercial SIT using a GEO satellite EDUSAT which is especially dedicated for satellite based e-Learning. The internal detail of the DVB-RCS Forward and Return Link Organization and how it manages the Satellite Interactive Terminals access to the satellite channel using MF-TDMA approach has been described.

  20. Topology and Non-Deterministic Polynomial Time Computation : Avoidance of The Misbehaviour of Hub-Free Diagrams and Consequences

    Directory of Open Access Journals (Sweden)

    Anthony Gasperin

    2013-09-01

    Full Text Available To study groups with small Dehn's function, Olshanskii and Sapir developed a new invariant of bipartite chords diagrams and applied it to hub-free realization of S-machines. In this paper we consider this new invariant together with groups constructed from S-machines containing the hub relation. The idea is to study the links between the topology of the asymptotic cones and polynomial time computations. Indeed it is known that the topology of such metric space depends on diagrams without hubs that do not correspond to the computations of the considered S-machine. This work gives sufficient conditions that avoid this misbehaviour, but as we shall see the method has a significant drawback.

  1. Aircraft height estimation using 2-D radar

    CSIR Research Space (South Africa)

    Hakl, H

    2010-01-01

    Full Text Available A method to infer height information from an aircraft tracked with a single 2-D search radar is presented. The method assumes level flight in the target aircraft and a good estimate of the speed of the aircraft. The method yields good results...

  2. Height as a Basis for Interpersonal Attraction.

    Science.gov (United States)

    Hensley, Wayne E.

    Based on the observation that taller males seem to have an advantage in date/mate selection, a study investigated the role that height plays in the choice of a partner. Subjects, 594 student volunteers from communication classes at a large Mid-Atlantic university, completed a questionnaire designed to assess such factors as respondent sex, present…

  3. Intralocus sexual conflict over human height

    NARCIS (Netherlands)

    Stulp, Gert; Kuijper, Bram; Buunk, Abraham P.; Pollet, Thomas V.; Verhulst, Simon

    2012-01-01

    Intralocus sexual conflict (IASC) occurs when a trait under selection in one sex constrains the other sex from achieving its sex-specific fitness optimum. Selection pressures on body size often differ between the sexes across many species, including humans: among men individuals of average height en

  4. Statistical analysis on extreme wave height

    Digital Repository Service at National Institute of Oceanography (India)

    Teena, N.V.; SanilKumar, V.; Sudheesh, K.; Sajeev, R.

    the distributions fitted to the GEV with annual maximum approach and GPD with peaks over threshold approach have indicated that both GEV and GPD models gave similar or comparable wave height for the study area since there is no multiple storm event in a year...

  5. Lang's Height Conjecture and Szpiro's Conjecture

    CERN Document Server

    Silverman, Joseph H

    2009-01-01

    It is known that Szpiro's conjecture, or equivalently the ABC-conjecture, implies Lang's conjecture giving a uniform lower bound for the canonical height of nontorsion points on elliptic curves. In this note we show that a significantly weaker version of Szpiro's conjecture, which we call "prime-depleted," suffices to prove Lang's conjecture.

  6. An Analysis of Personality in Wuthering Heights

    Institute of Scientific and Technical Information of China (English)

    Liu Feng

    2011-01-01

    Compared to other two sisters,Emily Bronte has a few of works,just only one novel and some poets.However,it is the novel Wuthering Heights arousing more and more critics' attention after more than 100 years since it was born.The reason that a great works

  7. The Artistic Glamour of Wuthering Heights

    Institute of Scientific and Technical Information of China (English)

    Li Wenyan

    2012-01-01

    Emily Bronte's Wuthering Heights is a classical masterpiece,known as"the most peculiar novel"in the English literature.The paper focuses on its structure and main idea,so as to reveal its thrilling artistic glamour and its artistic style.

  8. Growth hormone: health considerations beyond height gain

    Science.gov (United States)

    The therapeutic benefit of growth hormone (GH) therapy in improving height in short children is widely recognized; however, GH therapy is associated with other metabolic actions that may be of benefit in these children. Beneficial effects of GH on body composition have been documented in several dif...

  9. Scale height determination of spiral galaxies

    Institute of Scientific and Technical Information of China (English)

    计朝晖; 商朝晖; 彭秋和

    1997-01-01

    The method adopted here is based on the rigorous solution of Poison’s equation for logarithmic disturbance density within finite thickness galaxies. After their spiral arms are fitted directly with logarithmic spirals, the morphological parameters, scale heights and their relative errors for 32 spiral galaxies, such as NGC4814, are ob-tained.

  10. The Roles of Symbols in Wuthering Heights

    Institute of Scientific and Technical Information of China (English)

    孙贻红

    2015-01-01

    In Wuthering Heights, Emily Bronte portrays the love story between Catherine and Heathcliff whose sincere love is killed for their different social status and only prevails beyond the real world. The roles of symbols in revealing this theme will be traced in this article.

  11. Environmental Assessment: Disposition of Maxwell Heights Annex

    Science.gov (United States)

    2005-07-01

    Maxwell Support Division May 4, 2005 Mr. David Rabon Tribal Historic Preservation Officer Cherokee Nation of Oklahoma P.O. Box 948 Tahlequah...Oklahoma 74465 RE: Disposal of the Existing Property and Facilities of the Maxwell Heights Annex Maxwell Air Force Base, Alabama Dear Mr. Rabon , The

  12. Height, sitting height, and leg length in relation with breast cancer risk in the E3N cohort

    National Research Council Canada - National Science Library

    Fagherazzi, Guy; Vilier, Alice; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Françoise; Mesrine, Sylvie

    2012-01-01

    If height is a well-established risk factor for breast cancer, leg length and sitting height are usually considered as better candidate biomarkers of growth hormone exposure than height, respectively...

  13. Spinal Elongation and its Effects on Seated Height in a Microgravity Environment (Spinal)

    Science.gov (United States)

    Rajulu, Sudhakar; Young, Karen

    2009-01-01

    The primary objective of this project is to provide information pertaining to changes in seated height due to spinal elongation in a microgravity environment. The proposed experiment aims to collect seated height data for subjects exposed to microgravity environments, provide information relating to seated height rate of change over time, and feed new information regarding the elongation of the spine forward into the design of Constellation systems. Historical data indicates that spinal elongation occurs when crewmembers are subjected to microgravity. In as little as two days, the typical crewmember will exhibit increases in stature of up to 3 percent. However, data has been collected only for crewmembers in standing postures, and a limited pool of subjects was available. Due to the criticality of seated height in the design of the Crew Exploration Vehicle (CEV), a better understanding of the effects of microgravity on seated height is necessary. Small changes in seated height that may not have impacted crew accommodation in previous programs will have significant effects on crew accommodation due to the layout of seats in the CEV. The proposed study will directly measure changes in seated height for crewmembers in the Shuttle cockpit. An anthropometer will be used to record measurements to the top of the head of a seated subject, and an orthogonal photograph will be taken in order to measure seated height based on scaling references of known sizes as well as verify the posture and positioning remained consistent throughout the study. Data gained from this study will provide better information to CEV designers. Accurate measurements of crew seated height will be valuable for vehicle and habitation designers for future programs as well.

  14. WHAT IS CONTROLLING THE FRAGMENTATION IN THE INFRARED DARK CLOUD G14.225–0.506?: DIFFERENT LEVELS OF FRAGMENTATION IN TWIN HUBS

    Energy Technology Data Exchange (ETDEWEB)

    Busquet, Gemma; Girart, Josep Miquel [Institut de Ciències de l’Espai (CSIC-IEEC), Campus UAB, Carrer de Can Magrans, S/N, E-08193, Cerdanyola del Vallès, Catalunya (Spain); Estalella, Robert [Departament d’Astronomia i Meteorologia, Institut de Ciències del Cosmos (ICC), Universitat de Barcelona (IEEC-UB), Martí i Franquès, 1, E-08028 Barcelona, Catalunya (Spain); Palau, Aina [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, P.O. Box 3-72, 58090 Morelia, Michoacán, México (Mexico); Liu, Hauyu Baobab; Ho, Paul T. P. [Academia Sinica Institute of Astronomy and Astrophysics, Taipei, Taiwan (China); Zhang, Qizhou [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); De Gregorio-Monsalvo, Itziar [European Southern Observatory (ESO), Karl-Schwarzschild-Str. 2, D-85748 Garching (Germany); Pillai, Thushara [Max Planck Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Anglada, Guillem, E-mail: busquet@ice.cat [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía, s/n, E-18008, Granada (Spain)

    2016-03-20

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225–0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 μm obtained with APEX and CSO telescopes. The large-scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 μm and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be responsible for determining the fragmentation level. We estimated several physical parameters, such as the level of turbulence and the magnetic field strength, and we found no significant differences between these hubs. The Jeans analysis indicates that the observed fragmentation is more consistent with thermal Jeans fragmentation compared with a scenario in which turbulent support is included. The lower fragmentation level observed in hub-N could be explained in terms of stronger UV radiation effects from a nearby H ii region, evolutionary effects, and/or stronger magnetic fields at small scales, a scenario that should be further investigated.

  15. Prediction and typicality in multiverse cosmology

    CERN Document Server

    Azhar, Feraz

    2015-01-01

    In the absence of a fundamental theory that precisely predicts values for observable parameters, anthropic reasoning attempts to constrain probability distributions over those parameters in order to facilitate the extraction of testable predictions. The utility of this approach has been vigorously debated of late, particularly in light of theories that claim we live in a multiverse, where parameters may take differing values in regions lying outside our observable horizon. Within this cosmological framework, we investigate the efficacy of top-down anthropic reasoning based on the weak anthropic principle. We argue contrary to recent claims that it is not clear one can either dispense with notions of typicality altogether or presume typicality, in comparing resulting probability distributions with observations. We show in a concrete, top-down setting related to dark matter, that assumptions about typicality can dramatically affect predictions, thereby providing a guide to how errors in reasoning regarding typi...

  16. Typical horticultural products between tradition and innovation

    Directory of Open Access Journals (Sweden)

    Innocenza Chessa

    2009-10-01

    Full Text Available Recent EU and National policies for agriculture and rural development are mainly focused to foster the production of high quality products as a result of the increasing demand of food safety, typical foods and traditional processing methods. Another word very often used to describe foods in these days is “typicality” which pools together the concepts of “food connected with a specific place”, “historical memory and tradition” and “culture”. The importance for the EU and the National administrations of the above mentioned kind of food is demonstrated, among other things, by the high number of the PDO, PGI and TSG certificated products in Italy. In this period of global markets and economical crisis farmers are realizing how “typical products” can be an opportunity to maintain their market share and to improve the economy of local areas. At the same time, new tools and strategy are needed to reach these goals. A lack of knowledge has being recognized also on how new technologies and results coming from recent research can help in exploiting traditional product and in maintaining the biodiversity. Taking into account the great variety and richness of typical products, landscapes and biodiversity, this report will describe and analyze the relationships among typicality, innovation and research in horticulture. At the beginning “typicality” and “innovation” will be defined also through some statistical features, which ranks Italy at the first place in terms of number of typical labelled products, then will be highlighted how typical products of high quality and connected with the tradition and culture of specific production areas are in a strict relationship with the value of agro-biodiversity. Several different examples will be used to explain different successful methods and/or strategies used to exploit and foster typical Italian vegetables, fruits and flowers. Finally, as a conclusion, since it is thought that

  17. 旅游枢纽理论与实践研究综述%A systematic literature review of tourism hub theory and practice

    Institute of Scientific and Technical Information of China (English)

    邹统钎; 江璐虹; 郭晓霞

    2016-01-01

    Research on tourism hubs in China and abroad are based on transportation hubs,after which the basic theory about tourism hubs occurred and boosted study on the theoretical and practical development of tourism hubs.Tourism hubs originated from transportation hubs.Based on transportation hubs,tourism hubs provide tourists with tourism-related information,service and infrastructure,as well as well-rounded,seamless and accessible integration of all kind of transports which make tourist transfers and travel more convenient.Tourism hubs bridge tourism markets and destinations,but there are differences between them.The tourism resources are main attractions for tourists while tourism hubs strike to control the local tourism industry through tourist flows.The functions of gathering and scattering are key factors for tourism hubs which help to control tourist flows and the tourism industry.According to different practical functions and various development processes of international tourism hubs,we generalize their practices and divide them into two categories:hub-dominated tourism cities and hub-destination tourism cities.The development of international tourism hubs follows similar laws.Well-constructed hubs,especially the airport hub network will be helpful for tourism hubs to attract tourist flow.Tourism hubs benefit from their hub functions and control of local tourism industries.With the development of the tourism industry,tourist destinations and tourism hubs tend to mix together.%旅游枢纽的国内外研究经历了“交通枢纽-旅游枢纽基础理论-旅游枢纽”的阶段演变.旅游枢纽的发展源于交通枢纽,以交通枢纽为基础,以人的运输为主,提供旅游配套的信息服务,并整合了一般公共交通等多种交通方式,为游客提供便捷服务.旅游枢纽是旅游客源地与目的地之间的中介与桥梁,旅游目的地主要通过拥有的旅游资源形成吸引物,旅游枢纽则通过流经

  18. Route Height Connection Across the Sea by Using the Vertical Deflections and Ellipsoidal Height Data

    Institute of Scientific and Technical Information of China (English)

    GUO Jin-yun; CHEN Yong-ning; LIU Xin; ZHONG Shi-xia; MAI Zhao-qiu

    2013-01-01

    Distance between the main land and island is so long that it is very difficult to precisely connect the height datum across the sea with the traditional method like the trigonometric leveling,or it is very expensive and takes long time to implement the height transfer with the geopotential technique.We combine the data of GPS surveying,astro-geodesy and EGM2008 to precisely connect the orthometric height across the sea with the improved astronomical leveling method in the paper.The Qiongzhou Strait is selected as the test area for the height connection over the sea.We precisely determine the geodetic latitudes,longitudes,heights and deflections of the vertical for four points on both sides across the strait.Modeled deflections of the vertical along the height connecting routes over the sea are determined with EGM2008 model based on the geodetic positions and heights of the sea segmentation points from DNSC08MSS model.Differences of the measured and modeled deflections of the vertical are calculated at four points on both sides and linearly change along the route.So the deflections of the vertical along the route over the sea can be improved by the linear interpolation model.The results are also in accord with those of trigonometirc levelings.The practical case shows that we can precisely connect the orthometric height across the Qiongzhou Strait to satisfy the requirement of order 3 leveling network of China.The method is very efficient to precisely connect the height datum across the sea along the route up to 80 km.

  19. Why primary care practices should become digital health information hubs for their patients.

    Science.gov (United States)

    Baird, Aaron; Nowak, Samantha

    2014-11-25

    Two interesting health care trends are currently occurring: 1) patient-facing technologies, such as personal health records, patient portals, and mobile health apps, are being adopted at rapid rates, and 2) primary care, which includes family practice, is being promoted as essential to reducing health care costs and improving health care outcomes. While these trends are notable and commendable, both remain subject to significant fragmentation and incentive misalignments, which has resulted in significant data coordination and value generation challenges. In particular, patient-facing technologies designed to increase care coordination, often fall prey to the very digital fragmentation issues they are supposed to overcome. Additionally, primary care providers are treating patients that may have considerable health information histories, but generating a single view of such multi-source data is nearly impossible. We contribute to this debate by proposing that primary care practices become digital health information hubs for their patients. Such hubs would offer health data coordination in a medically professional setting with the benefits of expert, trustworthy advice coupled with active patient engagement. We acknowledge challenges including: costs, information quality and provenance, willingness-to-share information and records, willingness-to-use (by both providers and patients), primary care scope creep, and determinations of technical and process effectiveness. Even with such potential challenges, we strongly believe that more debate is needed on this topic prior to full implementation of various health information technology incentives and reform programs currently being designed and enacted throughout the world. Ultimately, if we do not provide a meaningful way for the full spectrum of health information to be used by both providers and patients, especially early in the health care continuum, effectively improving health outcomes may remain elusive. We view

  20. Comparative Genomic Analysis Reveals Habitat-Specific Genes and Regulatory Hubs within the Genus Novosphingobium

    Science.gov (United States)

    Kumar, Roshan; Verma, Helianthous; Haider, Shazia; Bajaj, Abhay; Sood, Utkarsh; Ponnusamy, Kalaiarasan; Nagar, Shekhar; Shakarad, Mallikarjun N.; Negi, Ram Krishan; Singh, Yogendra; Khurana, J. P.; Gilbert, Jack A.

    2017-01-01

    ABSTRACT Species belonging to the genus Novosphingobium are found in many different habitats and have been identified as metabolically versatile. Through comparative genomic analysis, we identified habitat-specific genes and regulatory hubs that could determine habitat selection for Novosphingobium spp. Genomes from 27 Novosphingobium strains isolated from diverse habitats such as rhizosphere soil, plant surfaces, heavily contaminated soils, and marine and freshwater environments were analyzed. Genome size and coding potential were widely variable, differing significantly between habitats. Phylogenetic relationships between strains were less likely to describe functional genotype similarity than the habitat from which they were isolated. In this study, strains (19 out of 27) with a recorded habitat of isolation, and at least 3 representative strains per habitat, comprised four ecological groups—rhizosphere, contaminated soil, marine, and freshwater. Sulfur acquisition and metabolism were the only core genomic traits to differ significantly in proportion between these ecological groups; for example, alkane sulfonate (ssuABCD) assimilation was found exclusively in all of the rhizospheric isolates. When we examined osmolytic regulation in Novosphingobium spp. through ectoine biosynthesis, which was assumed to be marine habitat specific, we found that it was also present in isolates from contaminated soil, suggesting its relevance beyond the marine system. Novosphingobium strains were also found to harbor a wide variety of mono- and dioxygenases, responsible for the metabolism of several aromatic compounds, suggesting their potential to act as degraders of a variety of xenobiotic compounds. Protein-protein interaction analysis revealed β-barrel outer membrane proteins as habitat-specific hubs in each of the four habitats—freshwater (Saro_1868), marine water (PP1Y_AT17644), rhizosphere (PMI02_00367), and soil (V474_17210). These outer membrane proteins could play a

  1. Comparative Genomic Analysis Reveals Habitat-Specific Genes and Regulatory Hubs within the Genus Novosphingobium.

    Science.gov (United States)

    Kumar, Roshan; Verma, Helianthous; Haider, Shazia; Bajaj, Abhay; Sood, Utkarsh; Ponnusamy, Kalaiarasan; Nagar, Shekhar; Shakarad, Mallikarjun N; Negi, Ram Krishan; Singh, Yogendra; Khurana, J P; Gilbert, Jack A; Lal, Rup

    2017-01-01

    Species belonging to the genus Novosphingobium are found in many different habitats and have been identified as metabolically versatile. Through comparative genomic analysis, we identified habitat-specific genes and regulatory hubs that could determine habitat selection for Novosphingobium spp. Genomes from 27 Novosphingobium strains isolated from diverse habitats such as rhizosphere soil, plant surfaces, heavily contaminated soils, and marine and freshwater environments were analyzed. Genome size and coding potential were widely variable, differing significantly between habitats. Phylogenetic relationships between strains were less likely to describe functional genotype similarity than the habitat from which they were isolated. In this study, strains (19 out of 27) with a recorded habitat of isolation, and at least 3 representative strains per habitat, comprised four ecological groups-rhizosphere, contaminated soil, marine, and freshwater. Sulfur acquisition and metabolism were the only core genomic traits to differ significantly in proportion between these ecological groups; for example, alkane sulfonate (ssuABCD) assimilation was found exclusively in all of the rhizospheric isolates. When we examined osmolytic regulation in Novosphingobium spp. through ectoine biosynthesis, which was assumed to be marine habitat specific, we found that it was also present in isolates from contaminated soil, suggesting its relevance beyond the marine system. Novosphingobium strains were also found to harbor a wide variety of mono- and dioxygenases, responsible for the metabolism of several aromatic compounds, suggesting their potential to act as degraders of a variety of xenobiotic compounds. Protein-protein interaction analysis revealed β-barrel outer membrane proteins as habitat-specific hubs in each of the four habitats-freshwater (Saro_1868), marine water (PP1Y_AT17644), rhizosphere (PMI02_00367), and soil (V474_17210). These outer membrane proteins could play a key role in

  2. Modelling Typical Online Language Learning Activity

    Science.gov (United States)

    Montoro, Carlos; Hampel, Regine; Stickler, Ursula

    2014-01-01

    This article presents the methods and results of a four-year-long research project focusing on the language learning activity of individual learners using online tasks conducted at the University of Guanajuato (Mexico) in 2009-2013. An activity-theoretical model (Blin, 2010; Engeström, 1987) of the typical language learning activity was used to…

  3. A Futile Search for Values and Pedagogy? A Discursive Analysis of the Marketing Messages of Branch-Campuses in Higher Education Hubs

    Science.gov (United States)

    Karram, Grace

    2014-01-01

    Higher education has become a key strategy for the economic development of certain city-states that are positioning themselves as higher education hubs, recruiting both students and foreign providers. This article presents the findings of a research study that examined the online messages of foreign branch-campuses in education hubs (Dubai, Hong…

  4. Global trade & the Dutch hub: understanding variegated forms of embeddedness of international trade in the Netherlands: clothing, flowers, and high-tech products

    NARCIS (Netherlands)

    Levelt, M.

    2010-01-01

    As global trade increases, some regions have become specialized in international trade and logistics, forming hubs to larger market areas. Although a lot is known about international trade in quantitative terms, much less is known about actual trade activities taking place in trade hubs and the ways

  5. Global trade & the Dutch hub: understanding variegated forms of embeddedness of international trade in the Netherlands: clothing, flowers, and high-tech products

    NARCIS (Netherlands)

    Levelt, M.

    2010-01-01

    As global trade increases, some regions have become specialized in international trade and logistics, forming hubs to larger market areas. Although a lot is known about international trade in quantitative terms, much less is known about actual trade activities taking place in trade hubs and the ways

  6. Participant Adherence Indicators Predict Changes in Blood Pressure, Anthropometric Measures, and Self-Reported Physical Activity in a Lifestyle Intervention: HUB City Steps

    Science.gov (United States)

    Thomson, Jessica L.; Landry, Alicia S.; Zoellner, Jamie M.; Connell, Carol; Madson, Michael B.; Molaison, Elaine Fontenot; Yadrick, Kathy

    2015-01-01

    The objective of this secondary analysis was to evaluate the utility of several participant adherence indicators for predicting changes in clinical, anthropometric, dietary, fitness, and physical activity (PA) outcomes in a lifestyle intervention, HUB City Steps, conducted in a southern, African American cohort in 2010. HUB City Steps was a…

  7. Sagittal knee joint kinematics and energetics in response to different landing heights and techniques.

    Science.gov (United States)

    Yeow, C H; Lee, P V S; Goh, J C H

    2010-03-01

    Single-leg and double-leg landing techniques are common athletic maneuvers typically performed from various landing heights during intensive sports activities. However, it is still unclear how the knee joint responds in terms of kinematics and energetics to the combined effects of different landing heights and techniques. We hypothesized that the knee displays greater flexion angles and angular velocities, joint power and work in response to the larger peak ground reaction force from 0.6-m height, compared to 0.3-m height. We further hypothesized that the knee exhibits elevated flexion angles and angular velocities, joint power and work during double-leg landing, relative to single-leg landing. Ground reaction force, knee joint kinematics and energetics data were obtained from 10 subjects performing single-leg and double-leg landing from 0.3-m to 0.6-m heights, using motion-capture system and force-plates. Higher peak ground reaction force (pheight. We found greater knee flexion angles and angular velocities (pheight. Elevated knee joint power and work were noted (pheight. The knee joint is able to respond more effectively in terms of kinematics and energetics to a larger landing impact from an elevated height during double-leg landing, compared to single-leg landing. This allows better shock absorption and thus minimizes the risk of sustaining lower extremity injuries.

  8. Response of Maize Plant to Phosphorus Fertilization on Typic Distrudepts

    Directory of Open Access Journals (Sweden)

    Antonius Kasno

    2009-05-01

    Full Text Available On the acid soil, phosphorus nutrients become critical for agricultural crops growth. At the present, price of fertilizers significantly increase and fertilizers are not available. These conditions can affect on soil productivity and crop production. The objective of these research were to study the response of maize (Zea mays L. to phosphate fertilizers on Inceptisol. The research was conducted in Cicadas Village on Typic Dystrudept. Experiment was conducted in a randomized completely block design, with 8 treatments and three replications. Treatments consisted of 6 dosages of P fertilizers, which were P source is SP-36 WIKA Agro 0, 10, 20, 40, 60 and 80 kg ha-1. SP-36 and Tunisia rock phosphate (40 kg P ha-1 were used for standard. Pioneer 12 variety of maized was used as an indicator. Plot size was 5 m x 6 m and the maize was planting with distance of 75 cm x 20 cm with one seed per hole. The results showed that organic C and N, P (extracted by Bray 1, K and CEC on the soil were low. Phosphate fertilizers significantly increased which was P extracted by HCl 25% from 24 to 67 mg P 100 g-1 soil and which were extracted by Bray 1 increased from 0,87 to 63.31 mg P kg-1 soil. Phosphate fertilizers significantly increased plant height from 175.2 cm become to 221.1 cm. Plant height of maize using SP-36 WIKA Agro fertilizer (210.6 cm was similar to plant heigh using SP-36 fertilizer (213.4 cm but less height from Tunisia rock phosphate. The yield of maize on SP-36 WIKA Agro (4.94 t ha-1 were linely higher than SP-36 (4.69 t ha-1, significantly was higher than that of Tunisia rock phosphate. Maximum dosage of SP-36 fertilizer was 66.67 kg P ha-1, and optimum dosage was 42 kg P ha-1. Value of Relative Agronomic Effectiveness SP-36 WIKA Agro fertilizer was heigher than SP-36.

  9. Helicity at Photospheric and Chromospheric Heights

    CERN Document Server

    Tiwari, S K; Sankarasubramanian, K

    2009-01-01

    In the solar atmosphere the twist parameter $\\alpha$ has the same sign as magnetic helicity. It has been observed using photospheric vector magnetograms that negative/positive helicity is dominant in the northern/southern hemisphere of the Sun. Chromospheric features show dextral/sinistral dominance in the northern/southern hemisphere and sigmoids observed in X-rays also have a dominant sense of reverse-S/forward-S in the northern/southern hemisphere. It is of interest whether individual features have one-to-one correspondence in terms of helicity at different atmospheric heights. We use UBF \\Halpha images from the Dunn Solar Telescope (DST) and other \\Halpha data from Udaipur Solar Observatory and Big Bear Solar Observatory. Near-simultaneous vector magnetograms from the DST are used to establish one-to-one correspondence of helicity at photospheric and chromospheric heights. We plan to extend this investigation with more data including coronal intensities.

  10. BOREAS AFM-6 Boundary Layer Height Data

    Science.gov (United States)

    Wilczak, James; Hall, Forrest G. (Editor); Newcomer, Jeffrey A. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    The Boreal Ecosystem-Atmosphere Study (BOREAS) Airborne Fluxes and Meteorology (AFM)-6 team from National Oceanic and Atmospheric Adminsitration/Environment Technology Laboratory (NOAA/ETL) operated a 915-MHz wind/Radio Acoustic Sounding System (RASS) profiler system in the Southern Study Area (SSA) near the Old Jack Pine (OJP) site. This data set provides boundary layer height information over the site. The data were collected from 21 May 1994 to 20 Sep 1994 and are stored in tabular ASCII files. The boundary layer height data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files are available on a CD-ROM (see document number 20010000884).

  11. Adaptive Layer Height During DLP Materials Processing

    DEFF Research Database (Denmark)

    Pedersen, David Bue; Zhang, Yang; Nielsen, Jakob Skov

    2016-01-01

    for considerable process speedup during the Additive Manufacture of components that contain areas of low cross-section variability, at no loss of surface quality. The adaptive slicing strategy was tested with a purpose built vat polymerisation system and numerical engine designed and constructed to serve as a Next......This research aim to show how manufacturing speeds during vat polymerisation can be vastly increased through an adaptive layer height strategy that takes the geometry into account through analysis of the relationship between layer height, cross-section variability and surface structure. This allows......-Gen technology platform. By means of assessing hemispherical manufactured test specimen and through 3D surface mapping with variable-focus microscopy and confocal microscopy, a balance between minimal loss of surface quality with a maximal increase of manufacturing rate has been identified as a simple angle...

  12. Accurate barrier heights using diffusion Monte Carlo

    CERN Document Server

    Krongchon, Kittithat; Wagner, Lucas K

    2016-01-01

    Fixed node diffusion Monte Carlo (DMC) has been performed on a test set of forward and reverse barrier heights for 19 non-hydrogen-transfer reactions, and the nodal error has been assessed. The DMC results are robust to changes in the nodal surface, as assessed by using different mean-field techniques to generate single determinant wave functions. Using these single determinant nodal surfaces, DMC results in errors of 1.5(5) kcal/mol on barrier heights. Using the large data set of DMC energies, we attempted to find good descriptors of the fixed node error. It does not correlate with a number of descriptors including change in density, but does correlate with the gap between the highest occupied and lowest unoccupied orbital energies in the mean-field calculation.

  13. Height predicts jealousy differently for men and women

    NARCIS (Netherlands)

    Buunk, Abraham P.; Park, Justin H.; Zurriaga, Rosario; Klavina, Liga; Massar, Karlijn

    Because male height is associated with attractiveness, dominance, and reproductive success, taller men may be less jealous. And because female height has a curvilinear relationship with health and reproductive success (with average-height females having the advantages), female height may have a

  14. Leg length, sitting height and postmenopausal breast cancer risk

    DEFF Research Database (Denmark)

    Mellemkjær, L; Christensen, J; Frederiksen, K

    2012-01-01

    Tallness has consistently been associated with an increased risk of breast cancer. We investigated the association further by decomposing height into leg length and sitting height.......Tallness has consistently been associated with an increased risk of breast cancer. We investigated the association further by decomposing height into leg length and sitting height....

  15. Height predicts jealousy differently for men and women

    NARCIS (Netherlands)

    Buunk, Abraham P.; Park, Justin H.; Zurriaga, Rosario; Klavina, Liga; Massar, Karlijn

    2008-01-01

    Because male height is associated with attractiveness, dominance, and reproductive success, taller men may be less jealous. And because female height has a curvilinear relationship with health and reproductive success (with average-height females having the advantages), female height may have a curv

  16. Measuring Ice Sheet Height with ICESat-2

    Science.gov (United States)

    Walsh, K.; Smith, B.; Neumann, T.; Hancock, D.

    2015-12-01

    ICESat-2 is NASA's next-generation laser altimeter, designed to measure changes in ice sheet height and sea ice freeboard. Over the ice sheets, it will use a continuous repeat-track pointing strategy to ensure that it accurately measures elevation changes along a set of reference tracks. Over most of the area of Earth's ice sheets, ICESat-2 will provide coverage with a track-to-track spacing better than ~3 km. The onboard ATLAS instrument will use a photon-counting approach to provide a global geolocated photon point cloud, which is then converted into surface-specific elevation data sets. In this presentation, we will outline our strategy for taking the low-level photon point cloud and turning it into measurements posted at 20 m along-track for a set of pre-defined reference points by (1) selecting groups of photon events (PEs) around each along-track point, (2) refining the initial PE selection by fitting selected PEs with an along-track segment model and eliminating outliers to the model, (3) applying histogram-based corrections to the surface height based on the residuals to the along-track segment model, (4) calculate error estimates based on estimates of relative contributions of signal and noise PEs to the observed PE count, and (5) determining the final location and surface height of the along-track segment. These measurements are then corrected for short-scale (100-200 m) across-track surface topography around the reference points to develop a time series of land ice heights. The resulting data products will allow us to measure ice sheet elevation change with a point-for-point accuracy of a few centimeters over Earth's ice sheets.

  17. Feynman amplitudes and limits of heights

    Science.gov (United States)

    Amini, O.; Bloch, S. J.; Burgos Gil, J. I.; Fresán, J.

    2016-10-01

    We investigate from a mathematical perspective how Feynman amplitudes appear in the low-energy limit of string amplitudes. In this paper, we prove the convergence of the integrands. We derive this from results describing the asymptotic behaviour of the height pairing between degree-zero divisors, as a family of curves degenerates. These are obtained by means of the nilpotent orbit theorem in Hodge theory.

  18. Creating a global rare disease patient registry linked to a rare diseases biorepository database: Rare Disease-HUB (RD-HUB).

    Science.gov (United States)

    Rubinstein, Yaffa R; Groft, Stephen C; Bartek, Ronald; Brown, Kyle; Christensen, Ronald A; Collier, Elaine; Farber, Amy; Farmer, Jennifer; Ferguson, John H; Forrest, Christopher B; Lockhart, Nicole C; McCurdy, Kate R; Moore, Helen; Pollen, Geraldine B; Richesson, Rachel; Miller, Vanessa Rangel; Hull, Sara; Vaught, Jim

    2010-09-01

    A movement to create a global patient registry for as many as 7,000 rare diseases was launched at a workshop, "Advancing Rare Disease Research: The Intersection of Patient Registries, Biospecimen Repositories, and Clinical Data." http://rarediseases.info.nih.gov/PATIENT_REGISTRIES_WORKSHOP/. The workshop was sponsored by the Office of Rare Diseases Research (ORDR). The focus was the building of an infrastructure for an internet-based global registry linking to biorepositories. Such a registry would serve the patients, investigators, and drug companies. To aid researchers the participants suggested the creation of a centralized database of biorepositories for rare biospecimens (RD-HUB)http://biospecimens.ordr.info.nih.gov/ that could be linked to the registry. Over two days of presentations and breakout sessions, several hundred attendees discussed government rules and regulations concerning privacy and patients' rights and the nature and scope of data to be entered into a central registry as well as concerns about how to validate patient and clinician-entered data to ensure data accuracy. Mechanisms for aggregating data from existing registries were also discussed. The attendees identified registry best practices, model coding systems, international systems for recruiting patients into clinical trials and novel ways of using the internet directly to invite participation in research. They also speculated about who would bear ultimate responsibility for the informatics in the registry and who would have access to the information. Hurdles associated with biospecimen collection and how to overcome them were detailed. The development of the recommendations was, in itself, an indication of the commitment of the rare disease community as never before.

  19. A New Dynamic Model for a Flexible Hub-Beam System

    Institute of Scientific and Technical Information of China (English)

    LIU Zhu-yong; HONG Jia-zhen; CAI Guo-ping

    2009-01-01

    In this paper, a new dynamic model for the flexible hub-beam system is proposed by using the principle of continuum medium mechanics and the finite element discretization method. In the proposed model, the coupling deformation of any element of the beam is only related with the nodal coordinates of this element. So this model is suitable to the rotating beam in an arbitrary shape. Numerical examples of slender beams in straight and irregular shapes are carried out to demonstrate the validation of the proposed model. Simulation results indicate that the proposed model can be used valid for dynamic description of flexible rotating beam in irregular shape, and for both low and high rotation speeds.

  20. The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper)

    Science.gov (United States)

    Bongs, K.; Boyer, V.; Cruise, M. A.; Freise, A.; Holynski, M.; Hughes, J.; Kaushik, A.; Lien, Y.-H.; Niggebaum, A.; Perea-Ortiz, M.; Petrov, P.; Plant, S.; Singh, Y.; Stabrawa, A.; Paul, D. J.; Sorel, M.; Cumming, D. R. S.; Marsh, J. H.; Bowtell, R. W.; Bason, M. G.; Beardsley, R. P.; Campion, R. P.; Brookes, M. J.; Fernholz, T.; Fromhold, T. M.; Hackermuller, L.; Krüger, P.; Li, X.; Maclean, J. O.; Mellor, C. J.; Novikov, S. V.; Orucevic, F.; Rushforth, A. W.; Welch, N.; Benson, T. M.; Wildman, R. D.; Freegarde, T.; Himsworth, M.; Ruostekoski, J.; Smith, P.; Tropper, A.; Griffin, P. F.; Arnold, A. S.; Riis, E.; Hastie, J. E.; Paboeuf, D.; Parrotta, D. C.; Garraway, B. M.; Pasquazi, A.; Peccianti, M.; Hensinger, W.; Potter, E.; Nizamani, A. H.; Bostock, H.; Rodriguez Blanco, A.; Sinuco-Leon, G.; Hill, I. R.; Williams, R. A.; Gill, P.; Hempler, N.; Malcolm, G. P. A.; Cross, T.; Kock, B. O.; Maddox, S.; John, P.

    2016-04-01

    The UK National Quantum Technology Hub in Sensors and Metrology is one of four flagship initiatives in the UK National of Quantum Technology Program. As part of a 20-year vision it translates laboratory demonstrations to deployable practical devices, with game-changing miniaturized components and prototypes that transform the state-of-the-art for quantum sensors and metrology. It brings together experts from the Universities of Birmingham, Glasgow, Nottingham, Southampton, Strathclyde and Sussex, NPL and currently links to over 15 leading international academic institutions and over 70 companies to build the supply chains and routes to market needed to bring 10-1000x improvements in sensing applications. It seeks, and is open to, additional partners for new application development and creates a point of easy open access to the facilities and supply chains that it stimulates or nurtures.

  1. Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubs.

    Science.gov (United States)

    Fox, Philip D; Haberkorn, Christopher J; Weigel, Aubrey V; Higgins, Jenny L; Akin, Elizabeth J; Kennedy, Matthew J; Krapf, Diego; Tamkun, Michael M

    2013-09-01

    In mammalian cells, the cortical endoplasmic reticulum (cER) is a network of tubules and cisterns that lie in close apposition to the plasma membrane (PM). We provide evidence that PM domains enriched in underlying cER function as trafficking hubs for insertion and removal of PM proteins in HEK 293 cells. By simultaneously visualizing cER and various transmembrane protein cargoes with total internal reflectance fluorescence microscopy, we demonstrate that the majority of exocytotic delivery events for a recycled membrane protein or for a membrane protein being delivered to the PM for the first time occur at regions enriched in cER. Likewise, we observed recurring clathrin clusters and functional endocytosis of PM proteins preferentially at the cER-enriched regions. Thus the cER network serves to organize the molecular machinery for both insertion and removal of cell surface proteins, highlighting a novel role for these unique cellular microdomains in membrane trafficking.

  2. Southern African Office of Astronomy for Development: A New Hub for Astronomy for Development

    Science.gov (United States)

    Mutondo, Moola S.; Simpemba, Prospery

    2016-10-01

    A new Astronomy for Development hub needs innovative tools and programs. SAROAD is developing exciting tools integrating Raspberry Pi technology to bring cost-effective astronomy content to learning centres. SAROAD would also like to report achievements in realizing the IAU's strategic plan. In order to manage, evaluate and coordinate regional IAU (International Astronomical Union) capacity building programmes, including the recruitment and mobilization of volunteers, SAROAD has built an intranet that is accessible to regional members upon request. Using this resource, regional members can see and participate in regional activities. SAROAD has commenced with projects in the three Task Force areas of Universities and Research, Children and Schools and Public Outreach. Under the three Task Force areas, a total of seven projects have commenced in Zambia (some supported by funds from IAU Annual Call for proposals).

  3. The Development of Jomo Kenyatta International Airport as a Regional Aviation Hub

    Science.gov (United States)

    Irandu, Evaristus M.; Rhoades, Dawna L.

    2006-01-01

    Air transportation plays an important role in the social and economic development of the global system and the countries that seek to participate in it. As Africa seeks to take its place in the global economy, it is increasingly looking to aviation as the primary means of connecting its people and goods with the world. It has been suggested that Africa as a continent needs to move toward a system of hubs to optimize its scarce resources. Jomo Kenyatta International Airport in Nairobi, Kenya, is one of the airports in the eastern region of Africa that is seeking to fill this role. This paper discusses the prospects for success and the challenges that it will need to overcome, including projections through 2020 for the growth in passenger and cargo traffic.

  4. Membrane contact sites, ancient and central hubs of cellular lipid logistics.

    Science.gov (United States)

    Jain, Amrita; Holthuis, Joost C M

    2017-09-01

    Membrane contact sites (MCSs) are regions where two organelles are closely apposed to facilitate molecular communication and promote a functional integration of compartmentalized cellular processes. There is growing evidence that MCSs play key roles in controlling intracellular lipid flows and distributions. Strikingly, even organelles connected by vesicular trafficking exchange lipids en bulk via lipid transfer proteins that operate at MCSs. Herein, we describe how MCSs developed into central hubs of lipid logistics during the evolution of eukaryotic cells. We then focus on how modern eukaryotes exploit MCSs to help solve a major logistical problem, namely to preserve the unique lipid mixtures of their early and late secretory organelles in the face of extensive vesicular trafficking. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. Copyright © 2017. Published by Elsevier B.V.

  5. MNCS' PERCEPTION ON THE FEASIBILITY OF SOUTH KOREA AS A BUSINESS HUB OF NORTHEAST ASIA

    Directory of Open Access Journals (Sweden)

    You-Il Lee

    2004-01-01

    Full Text Available Since the financial crisis of 1997, the South Korean government has moved towards a new market-driven paradigm of economic growth based on foreign direct investment (FDI replacing the decades old state-driven economic growth model. One of the attempts made by the government is its ambition to transform the nation into a business and economic hub of Northeast Asia. However, despite the growing concern on the topic among government agencies, media, research centers and academia, the absence of a cohesive and realistic approach to the issue is a relative void in the literature. This paper, which is based on findings from interviews with foreign companies operating in Korea during 2002, offers a cultural and institutional insight into the critical and often invisible issues to be considered for a successful realization of the vision.

  6. On the interconnection of stable protein complexes: inter-complex hubs and their conservation in Saccharomyces cerevisiae and Homo sapiens networks.

    Science.gov (United States)

    Guerra, Concettina

    2015-01-01

    Protein complexes are key molecular entities that perform a variety of essential cellular functions. The connectivity of proteins within a complex has been widely investigated with both experimental and computational techniques. We developed a computational approach to identify and characterise proteins that play a role in interconnecting complexes. We computed a measure of inter-complex centrality, the crossroad index, based on disjoint paths connecting proteins in distinct complexes and identified inter-complex hubs as proteins with a high value of the crossroad index. We applied the approach to a set of stable complexes in Saccharomyces cerevisiae and in Homo sapiens. Just as done for hubs, we evaluated the topological and biological properties of inter-complex hubs addressing the following questions. Do inter-complex hubs tend to be evolutionary conserved? What is the relation between crossroad index and essentiality? We found a good correlation between inter-complex hubs and both evolutionary conservation and essentiality.

  7. Gravity and Height Variations at Medicina, Italy

    Science.gov (United States)

    Bruni, Sara; Zerbini, Susanna; Errico, Maddalena; Santi, Efisio; Wziontek, Hartmut

    2017-04-01

    Since 1996, at the Medicina station, height and gravity variations are monitored continuously by means of GPS, VLBI and superconducting gravimeter (SG) data. Additionally, absolute gravity observations are performed twice a year and environmental parameters, among others water table levels, are regularly acquired. Levelling between the different monuments at the site area is also carried out repeatedly to constrain local ties in the vertical position. Two GPS systems are located very close to each other, and both are in close proximity to the VLBI antenna. Twenty years of data are now available, which allow investigating both long- and short-period height and gravity signals together with their relevant correlations. Natural land subsidence, which is well known to occur in the area, is a major component of the observed long-term behavior; however, non-linear long-period signatures are also present in the time series. On a shorter time scale, fingerprints of the water table seasonal oscillations can be recognized in the data. The Medicina site is characterized by clayey soil subjected to consolidation effects when the water table lowers during summer periods. The pillar on which the SG is installed is especially affected because of its shallow foundation, causing height decreases in the order of 2.5-3 cm for water table lowering of 2 m. This study presents a comparative analysis of the different data sets with the aim of separating mass and deformation contributions in the SG gravity record.

  8. Algorithmic height compression of unordered trees.

    Science.gov (United States)

    Ben-Naoum, Farah; Godin, Christophe

    2016-01-21

    By nature, tree structures frequently present similarities between their sub-parts. Making use of this redundancy, different types of tree compression techniques have been designed in the literature to reduce the complexity of tree structures. A popular and efficient way to compress a tree consists of merging its isomorphic subtrees, which produces a directed acyclic graph (DAG) equivalent to the original tree. An important property of this method is that the compressed structure (i.e. the DAG) has the same height as the original tree, thus limiting partially the possibility of compression. In this paper we address the problem of further compressing this DAG in height. The difficulty is that compression must be carried out on substructures that are not exactly isomorphic as they are strictly nested within each-other. We thus introduced a notion of quasi-isomorphism between subtrees that makes it possible to define similar patterns along any given path in a tree. We then proposed an algorithm to detect these patterns and to merge them, thus leading to compressed structures corresponding to DAGs augmented with return edges. In this way, redundant information is removed from the original tree in both width and height, thus achieving minimal structural compression. The complete compression algorithm is then illustrated on the compression of various plant-like structures.

  9. A global boundary-layer height climatology

    Energy Technology Data Exchange (ETDEWEB)

    Dop, H. van; Krol, M.; Holtslag, B. [Inst. for Marine and Atmospheric Research Utrecht, IMAU, Utrecht (Netherlands)

    1997-10-01

    In principle the ABL (atmospheric boundary layer) height can be retrieved from atmospheric global circulation models since they contain algorithms which determine the intensity of the turbulence as a function of height. However, these data are not routinely available, or on a (vertical) resolution which is too crude in view of the application. This justifies the development of a separate algorithm in order to define the ABL. The algorithm should include the generation of turbulence by both shear and buoyancy and should be based on readily available atmospheric parameters. There is obviously a wide application for boundary heights in off-line global and regional chemistry and transport modelling. It is also a much used parameter in air pollution meteorology. In this article we shall present a theory which is based on current insights in ABL dynamics. The theory is applicable over land and sea surfaces in all seasons. The theory is (for various reasons) not valid in mountainous areas. In areas where boundary-layer clouds or deep cumulus convection are present the theory does not apply. However, the same global atmospheric circulation models contain parameterizations for shallow and deep convection from which separate estimates can be obtained for the extent of vertical mixing. (au)

  10. A brief treatment for fear of heights.

    Science.gov (United States)

    Arroll, Bruce; Henwood, Suzanne M; Sundram, Fred I; Kingsford, Douglas W; Mount, Vicki; Humm, Steve P; Wallace, Henry B; Pillai, Avinesh

    2017-01-01

    Objective To assess the effectiveness of a novel imaginal intervention for people with acrophobia. Methods The design was a randomized controlled trial with concealed randomization and blinded to other participants' intervention. The intervention was a single novel imaginal intervention session or a 15-min meditation. The setting was in Auckland, New Zealand. The participants were a convenience sample of the public with a score >29 on the Heights Interpretation Questionnaire (HIQ), a questionnaire validated against actual height exposure. The primary outcomes were the proportion of participants with a score fear of heights is very much improved. There was a 4.5-point difference in the HIQ score at eight weeks (p = 0.055) on the multiple regression analysis. Conclusions This is the first randomized trial of this novel imaginal intervention which is probably effective, brief, easily learnt, and safe. It may be worth considering doing this prior to some of the longer or more expensive exposure therapies. This study will be of interest to family doctors, psychiatrists, and psychologists.

  11. A unique four-hub protein cluster associates to glioblastoma progression.

    Directory of Open Access Journals (Sweden)

    Pasquale Simeone

    Full Text Available Gliomas are the most frequent brain tumors. Among them, glioblastomas are malignant and largely resistant to available treatments. Histopathology is the gold standard for classification and grading of brain tumors. However, brain tumor heterogeneity is remarkable and histopathology procedures for glioma classification remain unsatisfactory for predicting disease course as well as response to treatment. Proteins that tightly associate with cancer differentiation and progression, can bear important prognostic information. Here, we describe the identification of protein clusters differentially expressed in high-grade versus low-grade gliomas. Tissue samples from 25 high-grade tumors, 10 low-grade tumors and 5 normal brain cortices were analyzed by 2D-PAGE and proteomic profiling by mass spectrometry. This led to identify 48 differentially expressed protein markers between tumors and normal samples. Protein clustering by multivariate analyses (PCA and PLS-DA provided discrimination between pathological samples to an unprecedented extent, and revealed a unique network of deranged proteins. We discovered a novel glioblastoma control module centered on four major network hubs: Huntingtin, HNF4α, c-Myc and 14-3-3ζ. Immunohistochemistry, western blotting and unbiased proteome-wide meta-analysis revealed altered expression of this glioblastoma control module in human glioma samples as compared with normal controls. Moreover, the four-hub network was found to cross-talk with both p53 and EGFR pathways. In summary, the findings of this study indicate the existence of a unifying signaling module controlling glioblastoma pathogenesis and malignant progression, and suggest novel targets for development of diagnostic and therapeutic procedures.

  12. Southern Africa Regional Office of Astronomy for Development: A New Hub for Astronomy for Development

    Science.gov (United States)

    Siseho Mutondo, Moola

    2015-08-01

    A new Astronomy for Development hub needs innovative tools and programs. SAROAD is developing exciting tools integrating Raspberry Pi® technology to bring cost-effective astronomy content to learning centres. SAROAD would also like to report achievements in realising the IAU's strategic plan. In order to manage, evaluate and coordinate regional IAU capacity building programmes, including the recruitment and mobilisation of volunteers, SAROAD has built an intranet that is accessible to regional members upon request. Using this resource, regional members can see and participate in regional activities. This resource also forms the foundation for closer collaboration between SAROAD member countries. SAROAD has commenced with projects in the three Task Force areas of Universities and Research, Children and Schools and Public Outreach. Under the three Task Force areas, a total of seven projects have commenced in Zambia. A further two projects involve the collaboration of Zambia and other regional member countries in order to foster engagement with important regional astronomy facilities (e.g. SKA). SAROAD has identified the IAU’s International Year of Light and a starting point for offering regional support for IAU-endorsed global activities. SAROAD has set up a hub dedicated to regional events and activities about the International Year of Light. SAROAD has a database of regional authorities to enable contact with the region's decision makers and experts. SAROAD will hold an annual event which brings forum for astronomy for development. The creation of the database and the SAROAD Road show is a first step towards this goal. The SAROAD website has helped to advertise upcoming events for astronomy development and education; it is used to provide advice, guidance and information for astronomers in all countries in the Southern Africa. Fundraising is the primary goal for SAROAD in 2015 towards financial self-sufficiency by 2020. We report on the methods that work best

  13. CFTR: a hub for kinases and crosstalk of cAMP and Ca2+.

    Science.gov (United States)

    Kunzelmann, Karl; Mehta, Anil

    2013-09-01

    Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a node within a network of signalling proteins. CFTR is not only a regulator of multiple transport proteins and controlled by numerous kinases but also participates in many signalling pathways that are disrupted after expression of its commonest mutant (F508del-CFTR). It operates in membrane compartments creating a scaffold for cytoskeletal elements, surface receptors, kinases and phosphodiesterases. CFTR is exposed to membrane-local second messengers such that a CFTR-interacting, low cellular energy sensor kinase (AMP- and ADP-activated kinase, AMPK) signals through a high energy phosphohistidine protein kinase (nucleoside diphosphate kinase, NDPK). CFTR also translocates a Ca(2+)-dependent adenylate cyclase to its proximity so that a rigid separation between cAMP-dependent and Ca(2+)-dependent regulation of Cl(-) transport becomes obsolete. In the presence of wild-type CFTR, parallel activation of CFTR and outwardly rectifying anoctamin 6 Cl(-) channels is observed, while the Ca(2+)-activated anoctamin 1 Cl(-) channel is inhibited. In contrast, in CF cells, CFTR is missing/mislocalized and the outwardly rectifying chloride channel is attenuated while Ca(2+)-dependent Cl(-) secretion (anoctamin 1) appears upregulated. Additionally, we consider the idea that F508del-CFTR when trapped in the endoplasmic reticulum augments IP3-mediated Ca(2+) release by providing a shunt pathway for Cl(-). CFTR and the IP3 receptor share the characteristic that they both assemble their partner proteins to increase the plasticity of their hub responses. In CF, the CFTR hub fails to form at the plasma membrane, with widespread detrimental consequences for cell signalling.

  14. White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs.

    Science.gov (United States)

    Klauser, Paul; Baker, Simon T; Cropley, Vanessa L; Bousman, Chad; Fornito, Alex; Cocchi, Luca; Fullerton, Janice M; Rasser, Paul; Schall, Ulrich; Henskens, Frans; Michie, Patricia T; Loughland, Carmel; Catts, Stanley V; Mowry, Bryan; Weickert, Thomas W; Shannon Weickert, Cynthia; Carr, Vaughan; Lenroot, Rhoshel; Pantelis, Christos; Zalesky, Andrew

    2017-03-01

    White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across studies is moderate. In this study, neuroimaging was used to investigate white matter pathology and its impact on whole-brain white matter connectivity in one of the largest samples of patients with schizophrenia. Fractional anisotropy (FA) and mean diffusivity (MD) were compared between patients with schizophrenia or schizoaffective disorder (n = 326) and age-matched healthy controls (n = 197). Between-group differences in FA and MD were assessed using voxel-based analysis and permutation testing. Automated whole-brain white matter fiber tracking and the network-based statistic were used to characterize the impact of white matter pathology on the connectome and its rich club. Significant reductions in FA associated with schizophrenia were widespread, encompassing more than 40% (234ml) of cerebral white matter by volume and involving all cerebral lobes. Significant increases in MD were also widespread and distributed similarly. The corpus callosum, cingulum, and thalamic radiations exhibited the most extensive pathology according to effect size. More than 50% of cortico-cortical and cortico-subcortical white matter fiber bundles comprising the connectome were disrupted in schizophrenia. Connections between hub regions comprising the rich club were disproportionately affected. Pathology did not differ between patients with schizophrenia and schizoaffective disorder and was not mediated by medication. In conclusion, although connectivity between cerebral hubs is most extensively disturbed in schizophrenia, white matter pathology is widespread, affecting all cerebral lobes and the cerebellum, leading to disruptions in the majority of the brain's fiber bundles. © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  15. Hubs of Anticorrelation in High-Resolution Resting-State Functional Connectivity Network Architecture.

    Science.gov (United States)

    Gopinath, Kaundinya; Krishnamurthy, Venkatagiri; Cabanban, Romeo; Crosson, Bruce A

    2015-06-01

    A major focus of brain research recently has been to map the resting-state functional connectivity (rsFC) network architecture of the normal brain and pathology through functional magnetic resonance imaging. However, the phenomenon of anticorrelations in resting-state signals between different brain regions has not been adequately examined. The preponderance of studies on resting-state fMRI (rsFMRI) have either ignored anticorrelations in rsFC networks or adopted methods in data analysis, which have rendered anticorrelations in rsFC networks uninterpretable. The few studies that have examined anticorrelations in rsFC networks using conventional methods have found anticorrelations to be weak in strength and not very reproducible across subjects. Anticorrelations in rsFC network architecture could reflect mechanisms that subserve a number of important brain processes. In this preliminary study, we examined the properties of anticorrelated rsFC networks by systematically focusing on negative cross-correlation coefficients (CCs) among rsFMRI voxel time series across the brain with graph theory-based network analysis. A number of methods were implemented to enhance the neuronal specificity of resting-state functional connections that yield negative CCs, although at the cost of decreased sensitivity. Hubs of anticorrelation were seen in a number of cortical and subcortical brain regions. Examination of the anticorrelation maps of these hubs indicated that negative CCs in rsFC network architecture highlight a number of regulatory interactions between brain networks and regions, including reciprocal modulations, suppression, inhibition, and neurofeedback.

  16. The degraded concept representation system in semantic dementia: damage to pan-modal hub, then visual spoke.

    Science.gov (United States)

    Hoffman, Paul; Jones, Roy W; Ralph, Matthew A Lambon

    2012-12-01

    The core clinical feature of semantic dementia is a progressive yet selective degradation of conceptual knowledge. Understanding the cognitive and neuroanatomical basis for this deficit is a key challenge for both clinical and basic science. Some researchers attribute the deficit to damage to pan-modal conceptual representations that are independent of any particular sensory-motor modality and are represented in the ventrolateral anterior temporal lobes. Others claim that damage to modality-specific visual feature representations in the occipitotemporal 'ventral stream' is responsible. In the present study, we tested the hypothesis that concept degradation in semantic dementia involves a combination of these pan-modal and modality-specific elements. We investigated factors influencing knowledge of object concepts by analysing 43 sets of picture-naming data from patients with semantic dementia. We found a strong influence of two pan-modal factors: highly familiar and typical items were named more accurately than less familiar/atypical items at all stages of the disorder. Items associated with rich sensory-motor information were also named more successfully at all stages, and this effect was present for sound/motion knowledge and tactile/action knowledge when these modalities were studied separately. However, there was no advantage for items rich in visual colour/form characteristics; instead, this factor had an increasingly negative impact in the later stages of the disorder. We propose that these results are best explained by a combination of (i) degradation of modality-independent conceptual representations, which is present throughout the disorder and is a consequence of atrophy focused on the ventrolateral anterior temporal lobes; and (ii) a later additional deficit for concepts that depend heavily on visual colour/form information, caused by the spreading of atrophy to posterior ventral temporal regions specialized for representing this information. This

  17. Differential evolution algorithm for multi-commodity and multi-level of service hub covering location problem

    Directory of Open Access Journals (Sweden)

    M. Setak

    2013-01-01

    Full Text Available The hub location problem involves a network of origins and destinations over which transportation takes place. There are many studies associated with finding the location of hub nodes and the allocation of demand nodes to these located hub nodes to transfer the only one kind of commodity under one level of service. However, in this study, carrying different commodity types from origin to destination under various levels of services (e.g. price, punctuality, reliability or transit time is studied. Quality of services experienced by users such as speed, convenience, comfort and security of transportation facilities and services is considered as the level of service. In each system, different kinds of commodities with various levels of services can be transmitted. The appropriate level of service that a commodity can be transmitted through is chosen by customer preferences and the specification of the commodity. So, a mixed integer programming formulation for single allocation hub covering location problem, which is based on the idea of transferring multi commodity flows under multi levels of service is presented. These two are applied concepts, multi-commodity and multi-level of service, which make the model's assumptions closer to the real world problems. In addition, a differential evolution algorithm is designed to find near-optimal solutions. The obtained solutions using differential evolution (DE algorithm (upper bound, where its parameters are tuned by response surface methodology, are compared with exact solutions and computed lower bounds by linear relaxation technique to prove the efficiency of proposed DE algorithm.

  18. Air network performance and hub competitive position: evaluation of primary airports in East and South-East Asia

    NARCIS (Netherlands)

    G. Burghouwt; J. de Wit; J. Veldhuis; H. Matsumoto

    2009-01-01

    The growth of hub-and-spoke operations has changed the structure of competition among airlines and airports, meaning that airlines now compete both directly (air services from A to B) as well as indirectly (services from A to B via H). Traditional measures of airport performance, such as passenger e

  19. Joint Optimization of Star P-hub Median Problem and Seat Inventory Control Decisions Considering a Hybrid Routing Transportation System

    Directory of Open Access Journals (Sweden)

    Hamid Tikani

    2016-11-01

    Full Text Available In this paper, we study the problem of integrated capacitated hub location problem and seat inventory control considering concept and techniques of revenue management. We consider an airline company maximizes its revenue by utilizing the best network topology and providing proper booking limits for all itineraries and fare classes. The transportation system arises in the form of a star/star network and includes both hub-stop and non-stop flights. This problem is formulated as a two-stage stochastic integer program with mixed-integer recourse. We solve various instances carried out from the Turkish network data set. Due to the NP-hardness of the problem, we propose a hybrid optimization method, consisting of an evolutionary algorithm based on genetic algorithm and exact solution. The quality of the solutions found by the proposed meta-heuristic is compared with the original version of GA and the mathematical programming model. The results obtained by the proposed model imply that integrating hub location and seat inventory control problem would help to increase the total revenue of airline companies. Also, in the case of serving non-stop flights, the model can provide more profit by employing less number of hubs.

  20. Optimization of Hybrid Hub-and-Spoke Network Operation for Less-Than-Truckload Freight Transportation considering Incremental Quantity Discount

    Directory of Open Access Journals (Sweden)

    Weiya Chen

    2014-01-01

    Full Text Available This paper presents a mixed integer linear programming model (MILP for optimizing the hybrid hub-and-spoke network operation for a less-than-truckload transportation service. The model aims to minimize the total operation costs (transportation cost and transfer cost, given the determined demand matrix, truck load capacity, and uncapacitated road transportation. The model also incorporates an incremental quantity discount function to solve the reversal of the total cost and the total demand. The model is applied to a real case of a Chinese transportation company engaged in nationwide freight transportation. The numerical example shows that, with uncapacitated road transportation, the total costs and the total vehicle trips of the hybrid hub-and-spoke network operation are, respectively, 8.0% and 15.3% less than those of the pure hub-and-spoke network operation, and the assumed capacity constraints in an extension model result in more target costs on the hybrid hub-and-spoke network. The two models can be used to support the decision making in network operations by transportation and logistics companies.

  1. The role of FlhF and HubP as polar landmark proteins in Shewanella putrefaciens CN-32.

    Science.gov (United States)

    Rossmann, Florian; Brenzinger, Susanne; Knauer, Carina; Dörrich, Anja K; Bubendorfer, Sebastian; Ruppert, Ulrike; Bange, Gert; Thormann, Kai M

    2015-11-01

    Spatiotemporal regulation of cell polarity plays a role in many fundamental processes in bacteria and often relies on 'landmark' proteins which recruit the corresponding clients to their designated position. Here, we explored the localization of two multi-protein complexes, the polar flagellar motor and the chemotaxis array, in Shewanella putrefaciens CN-32. We demonstrate that polar positioning of the flagellar system, but not of the chemotaxis system, depends on the GTPase FlhF. In contrast, the chemotaxis array is recruited by a transmembrane protein which we identified as the functional ortholog of Vibrio cholerae HubP. Mediated by its periplasmic N-terminal LysM domain, SpHubP exhibits an FlhF-independent localization pattern during cell cycle similar to its Vibrio counterpart and also has a role in proper chromosome segregation. In addition, while not affecting flagellar positioning, SpHubP is crucial for normal flagellar function and is involved in type IV pili-mediated twitching motility. We hypothesize that a group of HubP/FimV homologs, characterized by a rather conserved N-terminal periplasmic section required for polar targeting and a highly variable acidic cytoplasmic part, primarily mediating recruitment of client proteins, serves as polar markers in various bacterial species with respect to different cellular functions. © 2015 John Wiley & Sons Ltd.

  2. Dynamic Migration Intentions and the Impact of Socio-Institutional Environments: A Transit Migration Hub in Turkey

    NARCIS (Netherlands)

    Wissink, M.J.; Düvell, F.; van Eerdewijk, A.

    2013-01-01

    Transit migration is generally defined by migrants having the intention to move onwards to a third country. Based on an empirical investigation in Izmir, a transit migration hub in Turkey, this paper critically discusses intentionality as a valid dimension in conceptualisations of transit migration.

  3. Application of a Non-linear Program to the Establishment of a Hub and Spoke System in Africa

    Science.gov (United States)

    2010-06-01

    areas of commerce, light manufacturing, and the tourism industry (United States Department of State, 2009). Generally speaking, Kenya maintains a...possess commercial and/or military vehicle and equipment repair facilities that could be used to maintain CF materiel in theatre . The Hub...

  4. Dynamic Migration Intentions and the Impact of Socio-Institutional Environments: A Transit Migration Hub in Turkey

    NARCIS (Netherlands)

    Wissink, M.J.; Düvell, F.; van Eerdewijk, A.

    2013-01-01

    Transit migration is generally defined by migrants having the intention to move onwards to a third country. Based on an empirical investigation in Izmir, a transit migration hub in Turkey, this paper critically discusses intentionality as a valid dimension in conceptualisations of transit migration.

  5. The Quest for Regional Hub of Education: Growing Heterarchies, Organizational Hybridization, and New Governance in Singapore and Malaysia

    Science.gov (United States)

    Mok, Ka Ho

    2011-01-01

    With strong intention to enhance the global competitiveness of their higher education systems, the governments of Singapore and Malaysia have made attempts to develop their societies into regional hubs of education; hence transnational education has become increasingly popular in these societies. In order to attract more students from overseas to…

  6. Hub vortex helical instability as the origin of wake meandering in the lee of a model wind-turbine

    Science.gov (United States)

    Viola, Francesco; Iungo, Giacomo Valerio; Camarri, Simone; Porte-Agel, Fernando; Gallaire, Francois

    2012-11-01

    Wind tunnel measurements were performed for the wake produced by a three-bladed wind turbine immersed in uniform flow. These tests show the presence of a vorticity structure in the near wake region mainly oriented along the streamwise direction, which is denoted as hub vortex. The hub vortex is characterized by oscillations with frequencies lower than the one connected to the rotational velocity of the rotor, which are ascribed to wake meandering by previous works. This phenomenon consists in transversal oscillations of the wind turbine wake, which are excited by the shedding of vorticity structures from the rotor disc acting as a bluff body. In this work temporal and spatial linear stability analyses of a wind turbine wake are performed on a base flow obtained through time-averaged wind tunnel velocity measurements. This study shows that the low frequency spectral component detected experimentally is the result of a convective instability of the hub vortex, which is characterized by a counter-winding single-helix structure. Simultaneous hot-wire measurements confirm the presence of a helicoidal unstable mode of the hub vortex with a streamwise wavenumber roughly equal to the one predicted from the linear instability analysis.

  7. Developing and Launching an Online Hub to Facilitate the Exchange of Research Knowledge in Education: The Case of the OERE

    Science.gov (United States)

    Tuters, Stephanie; Read, Robyn; Harris, Shasta Carr; Anwar, Arif; Levin, Ben

    2012-01-01

    This paper outlines the process by which the Ontario Education Research Exchange (OERE), part of the Knowledge Network of Applied Education Research, developed and launched an online hub of education research summaries to facilitate greater use of research by stakeholders in the field of education. The project is an effort in knowledge…

  8. Debate over a Proposed FedEx Distribution Hub: Examining the Role of Consensus, Power and Norms of Communication Ethics.

    Science.gov (United States)

    Thompson, Kathleen B.

    This paper examines an ongoing community debate over a proposed FedEx distribution hub to be constructed at the local airport. The essay looks to theorists, including Patsy Healey, Richard Johannesen, Daniel Kemmis, James Klumpp, and Martha Nussbaum. These theorists provide a way to view the role of consensus, power, and norms of communication…

  9. Quantification of gait changes in subjects with visual height intolerance when exposed to heights

    Science.gov (United States)

    Schniepp, Roman; Kugler, Günter; Wuehr, Max; Eckl, Maria; Huppert, Doreen; Huth, Sabrina; Pradhan, Cauchy; Jahn, Klaus; Brandt, Thomas

    2014-01-01

    Introduction: Visual height intolerance (vHI) manifests as instability at heights with apprehension of losing balance or falling. We investigated contributions of visual feedback and attention on gait performance of subjects with vHI. Materials and Methods: Sixteen subjects with vHI walked over a gait mat (GAITRite®) on a 15-m-high balcony and at ground-level. Subjects walked at different speeds (slow, preferred, fast), during changes of the visual input (gaze straight/up/down; eyes open/closed), and while doing a cognitive task. An rmANOVA with the factors “height situation” and “gait condition” was performed. Subjects were also asked to estimate the height of the balcony over ground level. The individual estimates were used for correlations with the gait parameters. Results: Study participants walked slower at heights, with reduced cadence and stride length. The double support phases were increased (all p vHI; gait was similarly affected when the visual perception of the depth was prevented. Improvement by dual task at heights may be associated by a reduction of the anxiety level. Conclusion: It is conceivable that mental distraction by dual task or increasing the walking speed might be useful recommendations to reduce the imbalance during locomotion in subjects susceptible to vHI. PMID:25538595

  10. Herpes zoster - typical and atypical presentations.

    Science.gov (United States)

    Dayan, Roy Rafael; Peleg, Roni

    2017-08-01

    Varicella- zoster virus infection is an intriguing medical entity that involves many medical specialties including infectious diseases, immunology, dermatology, and neurology. It can affect patients from early childhood to old age. Its treatment requires expertise in pain management and psychological support. While varicella is caused by acute viremia, herpes zoster occurs after the dormant viral infection, involving the cranial nerve or sensory root ganglia, is re-activated and spreads orthodromically from the ganglion, via the sensory nerve root, to the innervated target tissue (skin, cornea, auditory canal, etc.). Typically, a single dermatome is involved, although two or three adjacent dermatomes may be affected. The lesions usually do not cross the midline. Herpes zoster can also present with unique or atypical clinical manifestations, such as glioma, zoster sine herpete and bilateral herpes zoster, which can be a challenging diagnosis even for experienced physicians. We discuss the epidemiology, pathophysiology, diagnosis and management of Herpes Zoster, typical and atypical presentations.

  11. Linguistic recycling in typical and atypical interaction.

    Science.gov (United States)

    Perkins, Michael R

    2014-01-01

    I present evidence that linguistic "recycling" - i.e., the redeployment of linguistic material from prior utterances during conversation - is a striking and prevalent feature not only of interaction between typical speakers, but also, and notably, of interaction involving the communication impaired. In the latter case, recycling may sometimes be used as a compensatory communicative resource when linguistic ability is compromised. Despite its prevalence, however, recycling has largely been ignored by clinical linguists. In addition to providing illustrations of linguistic recycling across a range of communication disorders, I also examine how it is subserved by phenomena such as priming, short-term memory and alignment. I subsequently argue for a shift in perspective that puts recycling at the heart of our perception of how typical and atypical interaction works, and suggest a number of potential benefits for clinical linguistics, ranging from the way we understand and analyse communication disorders to how we assess and treat them.

  12. Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score

    NARCIS (Netherlands)

    J.J. Lee (Jessica); J.C. Escher (Johanna); M.J. Shuman (Melissa); P.W. Forbes (Peter); L.C. Delemarre (Luçan); B.W. Harr (Brian); M. Kruijer (Marjan); M. Moret (Marlous); S. Allende-Richter (Sophie); R.J. Grand (Richard)

    2010-01-01

    textabstractBackground: This study was designed to elucidate the contribution of parental height to the stature of children with inflammatory bowel disease (IBD), who often exhibit growth impairment. Accordingly, we compared patients' final adult heights and target heights based on measured parental

  13. Group typicality, group loyalty and cognitive development.

    Science.gov (United States)

    Patterson, Meagan M

    2014-09-01

    Over the course of childhood, children's thinking about social groups changes in a variety of ways. Developmental Subjective Group Dynamics (DSGD) theory emphasizes children's understanding of the importance of conforming to group norms. Abrams et al.'s study, which uses DSGD theory as a framework, demonstrates the social cognitive skills underlying young elementary school children's thinking about group norms. Future research on children's thinking about groups and group norms should explore additional elements of this topic, including aspects of typicality beyond loyalty.

  14. THE CITY ISOMORPHISM FOR COMPREHENSIVE TRANSPORT HUB%综合交通枢纽的城市同构

    Institute of Scientific and Technical Information of China (English)

    魏崴

    2014-01-01

    The urban comprehensive transport hub comprises of multi-function transport facilities with great traffic characteristics like airport, harbor, country railways, metro-subway, public transportation, and crossover road. Both the deficiency of urban construction land and the limitation of severe environmental condition reflect the comprehensive urban problems. We need to integrate the present urban conditions and summarize the system of large-scale comprehensive transport hub, in order to intergrate the traffic system with the urban environment in the hub areas and to promote the interactive relationship between the service of traffic hub and the sustainable urban development. These are the core problems that the urban comprehensive transport hub faces nowadays. The article attempts to focus on the integration of transport hub space for railway station and the urban construction, to make a study on the design strategy of the coordinated development of the comprehensive transport hub and the urban construction, in order to broaden our perspective and make a wider horizon for the future healthy development of our city.%城市大型综合交通枢纽涵盖空港、海港、国铁、城市轨道交通、公交,以及立交道路等市政设施多元功能为一体,具有极强的交通特征。而城市建设用地紧张,环境制约因素繁多,反映了综合的城市问题。整合现有城市条件,梳理大型综合交通枢纽系统,实现枢纽地区交通组织和城市环境的融合,促进交通枢纽服务于城市可持续发展的互动关系,是城市综合交通枢纽建设面临的核心问题。本文尝试围绕铁路客站区域交通枢纽空间与城市建设一体化发展,研究综合交通枢纽与城市建设协同发展的设计策略,为探索城市未来的良性发展开拓思路,开启更为广阔的前景。

  15. What Is Typical Is Good : The Influence of Face Typicality on Perceived Trustworthiness

    NARCIS (Netherlands)

    Sofer, Carmel; Dotsch, Ron; Wigboldus, Daniel H J; Todorov, Alexander

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality’s influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness

  16. What Is Typical Is Good : The Influence of Face Typicality on Perceived Trustworthiness

    NARCIS (Netherlands)

    Sofer, Carmel; Dotsch, Ron|info:eu-repo/dai/nl/328554197; Wigboldus, Daniel H J; Todorov, Alexander

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality’s influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness

  17. Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins.

    Directory of Open Access Journals (Sweden)

    Debasree Sarkar

    Full Text Available A considerable proportion of protein-protein interactions (PPIs in the cell are estimated to be mediated by very short peptide segments that approximately conform to specific sequence patterns known as linear motifs (LMs, often present in the disordered regions in the eukaryotic proteins. These peptides have been found to interact with low affinity and are able bind to multiple interactors, thus playing an important role in the PPI networks involving date hubs. In this work, PPI data and de novo motif identification based method (MEME were used to identify such peptides in three cancer-associated hub proteins-MYC, APC and MDM2. The peptides corresponding to the significant LMs identified for each hub protein were aligned, the overlapping regions across these peptides being termed as overlapping linear peptides (OLPs. These OLPs were thus predicted to be responsible for multiple PPIs of the corresponding hub proteins and a scoring system was developed to rank them. We predicted six OLPs in MYC and five OLPs in MDM2 that scored higher than OLP predictions from randomly generated protein sets. Two OLP sequences from the C-terminal of MYC were predicted to bind with FBXW7, component of an E3 ubiquitin-protein ligase complex involved in proteasomal degradation of MYC. Similarly, we identified peptides in the C-terminal of MDM2 interacting with FKBP3, which has a specific role in auto-ubiquitinylation of MDM2. The peptide sequences predicted in MYC and MDM2 look promising for designing orthosteric inhibitors against possible disease-associated PPIs. Since these OLPs can interact with other proteins as well, these inhibitors should be specific to the targeted interactor to prevent undesired side-effects. This computational framework has been designed to predict and rank the peptide regions that may mediate multiple PPIs and can be applied to other disease-associated date hub proteins for prediction of novel therapeutic targets of small molecule PPI

  18. Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins

    Science.gov (United States)

    Sarkar, Debasree; Patra, Piya; Ghosh, Abhirupa; Saha, Sudipto

    2016-01-01

    A considerable proportion of protein-protein interactions (PPIs) in the cell are estimated to be mediated by very short peptide segments that approximately conform to specific sequence patterns known as linear motifs (LMs), often present in the disordered regions in the eukaryotic proteins. These peptides have been found to interact with low affinity and are able bind to multiple interactors, thus playing an important role in the PPI networks involving date hubs. In this work, PPI data and de novo motif identification based method (MEME) were used to identify such peptides in three cancer-associated hub proteins—MYC, APC and MDM2. The peptides corresponding to the significant LMs identified for each hub protein were aligned, the overlapping regions across these peptides being termed as overlapping linear peptides (OLPs). These OLPs were thus predicted to be responsible for multiple PPIs of the corresponding hub proteins and a scoring system was developed to rank them. We predicted six OLPs in MYC and five OLPs in MDM2 that scored higher than OLP predictions from randomly generated protein sets. Two OLP sequences from the C-terminal of MYC were predicted to bind with FBXW7, component of an E3 ubiquitin-protein ligase complex involved in proteasomal degradation of MYC. Similarly, we identified peptides in the C-terminal of MDM2 interacting with FKBP3, which has a specific role in auto-ubiquitinylation of MDM2. The peptide sequences predicted in MYC and MDM2 look promising for designing orthosteric inhibitors against possible disease-associated PPIs. Since these OLPs can interact with other proteins as well, these inhibitors should be specific to the targeted interactor to prevent undesired side-effects. This computational framework has been designed to predict and rank the peptide regions that may mediate multiple PPIs and can be applied to other disease-associated date hub proteins for prediction of novel therapeutic targets of small molecule PPI modulators. PMID

  19. Calculation of slope-cover height under price fluctuation in open-pit mines

    Institute of Scientific and Technical Information of China (English)

    Ma Jinyan; Cai Qingxiang; Liu Fuming; Chen Shuzhao

    2014-01-01

    Leaving ditches between adjacent mining areas can effectively reduce re-stripping in the latter mining area and simultaneously lead to an increment in internal dumping costs in the former mining area. This paper establishes calculation models for these two marginal costs. The optimizing model for slope cover height can be determined by including marginal cost models in the objective function. The paper has two main contributions:(a) it fully considers redistribution of dumping space in the model;(b) it introduces price fluctuations and cash discounts in the model. We use the typical open-pit mine as an example to test and prove the model. We conclude that a completely covered slope is reasonable in Haerwusu open pit mine;in addition to an increasing price index, the slope cover height can be reduced;and that price changes are one of the most important influencing factors of slope cover height optimization in an open-pit mine.

  20. Quantification of gait changes in subjects with visual height intolerance when exposed to heights

    Directory of Open Access Journals (Sweden)

    Roman eSchniepp

    2014-12-01

    Full Text Available Introduction: Visual height intolerance (vHI manifests as instability at heights with apprehension of losing balance or falling. We investigated contributions of visual feedback and attention on gait performance of subjects with vHI. Material and Methods: Sixteen subjects with vHI walked over a gait mat (GAITRite® on a 15-m-high balcony and at ground-level. Subjects walked at different speeds (slow, preferred, fast, during changes of the visual input (gaze straight/ up/ down; eyes open /closed, and while doing a cognitive task. An rmANOVA with the factors height situation and gait condition was performed. Subjects were also asked to estimate the height of the balcony over ground level. The individual estimates were used for correlations with the gait parameters.Results: Study participants walked slower at heights, with reduced cadence and stride length. The double support phases were increased (all p<0.01, which correlated with the estimated height of the balcony (R2=0.453, p<0.05. . These changes were still present when walking with upward gaze or closure of the eyes. Under the conditions walking and looking down to the floor of the balcony, during dual-task and fast walking, there were no differences between the gait performance on the balcony and at ground-level. Discussion: The found gait changes are features of a cautious gait control. Internal, cognitive models with anxiety play an important role for vHI; gait was similarly affected when the visual perception of the depth was prevented. . Improvement by dual task at heights may be associated by a reduction of the anxiety level.Conclusion: It is conceivable that mental distraction by dual task or increasing the walking speed might be useful recommendations to reduce the imbalance during locomotion in subjects susceptible to vHI.

  1. Comparison of Methods of Height Anomaly Computation

    Science.gov (United States)

    Mazurova, E.; Lapshin, A.; Menshova, A.

    2012-04-01

    As of today, accurate determination of height anomaly is one of the most difficult problems of geodesy, even with sustainable perfection of mathematical methods, computer possibilities. The most effective methods of height anomaly computation are based on the methods of discrete linear transformations, such as the Fast Fourier Transform (FFT), Short-Time Fourier Transform (STFT), Fast Wavelet Transform (FWT). The main drawback of the classical FFT is weak localization in the time domain. If it is necessary to define the time interval of a frequency presence the STFT is used that allows one to detect the presence of any frequency signal and the interval of its presence. It expands the possibilities of the method in comparison with the classical Fourier Transform. However, subject to Heisenberg's uncertainty principle, it is impossible to tell precisely what frequency signal is present at a given moment of time (it is possible to speak only about the range of frequencies); and it is impossible to tell at what precisely moment of time the frequency signal is present (it is possible to speak only about a time span). A wavelet-transform gives the chance to reduce the influence of the Heisenberg's uncertainty principle on the obtained time-and-frequency representation of the signal. With its help low frequencies have more detailed representation relative to the time, and high frequencies - relative to the frequency. The paper summarizes the results of height anomaly calculations done by the FFT, STFT, FWT methods and represents 3-D models of calculation results. Key words: Fast Fourier Transform(FFT), Short-Time Fourier Transform (STFT), Fast Wavelet Transform(FWT), Heisenberg's uncertainty principle.

  2. Boundary layer heights derived from velocity spectra

    Energy Technology Data Exchange (ETDEWEB)

    Hoejstrup, J.; Barthelmie, R.J. [Risoe National Lab., Roskilde (Denmark); Kaellstrand, B. [Univ. of Uppsala, Uppsala (Sweden)

    1997-10-01

    It is a well-known fact that the height of the mixed layer determines the size of the largest and most energetic eddies that can be observed in the unstable boundary layer, and consequently a peak can be observed in the power spectra of the along-wind velocity component at scales comparable to the mixed layer depth. We will now show how the mixed layer depth can be derived from the u-specta and the results will be compared with direct measurements using pibal and tethersonde measurements. (au)

  3. Scale heights of 84 northern spiral galaxies

    Institute of Scientific and Technical Information of China (English)

    马骏; 彭秋和

    1997-01-01

    Using the method proposed by Peng (1988) on the basis of density waves theory and the solution of three-dimensional Poisson s equation for a logarithmic disturbance of density,and analyzing the spiral patterns,the scale heights of 84 northern spiral galaxies,whose images are taken from the Digitized Sky Survey at Xinglong Observational Station of Beijing Observatory,are measured.The spiral arms of all these galaxies have been fitted on their photographs with some logarithmic spiral curves for getting their correct inclinations.

  4. Patella height changes post high tibial osteotomy

    Directory of Open Access Journals (Sweden)

    Siew Ghim Gooi

    2017-01-01

    Full Text Available Background: Medial opening wedge high tibial osteotomy (HTO is a well-described treatment in early medial compartmental osteoarthritis of the knee. However, two undesirable sequelae may follow –patella baja and changes in the posterior tibial slope (TS. Materials and Methods: We conducted a retrospective study in patients who underwent HTO in our center between September 2009 and February 2017. Preoperative and 6-week postoperative long-leg weight bearing films and lateral knee radiographs were assessed. Pre- and postoperative radiological measurements include the Caton-Deschamps Index (CDI, the mechanical axis deviation (MAD, and the posterior TS. Independant t-test and Pearson correlation test were performed. Results: A total of 106 knees were recruited. The mean age was 48.8 ± 10.8 years. 66 (62.3% and 40 (37.7% knees were from males and females, respectively. The mean pre- and postoperative measurements was (−9.70° ± 3.67° to 0.08° ± 2.80° (−varus; +valgus for the MAD, (7.14° ± 1.78° to 8.72° ± 3.11° for posterior TS, and (0.93° ± 0.084° to 0.82° ± 0.13° for CDI (P ≤ 0.001 for all. The association between patella height change and the level of osteotomy (supra-tubercle vs. infra-tubercle was statistically significant (P < 0.001. A supra-tubercle osteotomy cut significantly lowering patella height (P = 0.011. There was otherwise no statistically significant correlations between patella height changes and the correction angle (P = 0.187 or posterior TS change (P = 0.744. Conclusions: A medial opening wedge HTO above the tibial tubercle was significantly associated with lowering patella height or reducing CDI postoperatively. Based on our results, we would recommend the use of an infra-tubercle osteotomy during the corrective surgery to prevent the complication of patella baja.

  5. Typical Women Figures in Hemingway's Fictional World

    Institute of Scientific and Technical Information of China (English)

    杨春会; 范璐

    2008-01-01

    Ernest Hemingway is widely regarded as a giant figure in American literature, but meantime he is often criticized for his prejudice against women. However, whether Ernest Hemingway is a misogynist writer or not, I believe is largely depended on readers' comprehension of his works. This paper launched an interesting study on typical women characters in Hemingway's fictional world. The study also reveals that fact that far from being a misogynist writer, Hemingway shows great concern to women as a group. Not only did he own strong insight on women but also expressed his sympathy towards women.

  6. Hail damage to typical aircraft surfaces.

    Science.gov (United States)

    Hayduk, R. J.

    1972-01-01

    Severe structural damage can occur when aircraft collide with hailstones. Consequently, methods of predicting hail damage to airplane surfaces are needed by the aircraft designer. This paper describes an analytical method of predicting the dent depth and final deformed shape for simple structural components impacted by hailstones. The solution was accomplished by adapting the DEPROSS computer program to the problem of normal impact of hail on flat metallic sheets and spherical metallic caps. Experimental data and analytical predictions are presented for hail damage to typical aircraft surfaces along with a description of the hail gun and hail simulation technique used in the experimental study.

  7. Youth spare time: Typical patterns of behavior

    Directory of Open Access Journals (Sweden)

    Stepanović Ivana

    2009-01-01

    Full Text Available In this research we have tried to identify typical patterns of young people's behavior in their spare time and to use these patterns in order to group our subjects regarding their interests and preferences. Main-component analysis showed that it was possible to find different patterns of secondary school students' behavior in spare time as well as that the identified models could be the criteria for grouping them. Five patterns have been identified describing youth orientations towards their free time: academic orientation, orientation towards sports, orientation towards entertainment, orientation towards spending time going out and orientation towards music and computers.

  8. A Psychoanalytic Approach to Typical American

    Institute of Scientific and Technical Information of China (English)

    赵磊

    2015-01-01

    Typical American is the representative work of Gish Jen, a famous Chinese American woman writer. This novel is based on the three youth, Ralph, Theresa, and Helen who came to America to study and then became American citizens. This thesis tries to analyze the special psychological state of them from the perspective of psychoanalysis according to Freud 's psychoanalytic theo-ry. Through the writing of this thesis, the author regards that their specific psychoanalytic state is a group features. To learn these special features can help us have a good understanding of people coming from different cultural backgrounds.

  9. Height Determination Techniques for the Next National Height System of Finland- A Case Study

    Science.gov (United States)

    Saari, T.; Saaranen, V.; Kaartinen, H.; Poutanen, M.; Kukko, A.; Nyberg, S.

    2014-11-01

    Precise levelling is known for its accuracy and reliability in height determination, but the process itself is slow, laborious and expensive. FGI has started a project to develop methods for height determination that could decrease the creation time of national height systems without losing the required accuracy. In this pilot project, we studied precise levelling and alternative techniques: MLS (Mobile Laser Scanning) and GNSS (Global Navigation Satellite System) levelling, which included static GPS (Global Positioning System) and VRS (Virtual Reference Station) measurements.We compared the techniques in a field test, where the height difference of two known benchmarks were measured. All of the height differences were within 16 mm from each other, where the results from the precise levelling and the GPS levelling differed from 0.5-1.0 mm. Results from the MLS measurements were more than 5.0 mm off from the others and the average of the VRS measurements was 10.0 mm off. The uncertainties are compatible with the results, since the largest RMS values were calculated from the MLS and the VRS measurements.This research highlighted the differences of the techniques, but none of them is yet to be abandoned. The study should be expanded into a larger scale to better evaluate strengths and weaknesses of the techniques.

  10. Reaching new heights: comparing interpretation bias modification to exposure therapy for extreme height fear.

    Science.gov (United States)

    Steinman, Shari A; Teachman, Bethany A

    2014-06-01

    Cognitive models of anxiety disorders posit that biases in interpretation maintain, and potentially cause, anxiety. This study tested whether it is possible to decrease height fear symptoms through cognitive bias modification for interpretations (CBM-I). Additionally, the clinical utility of CBM-I was tested by comparing it to an already established treatment: exposure therapy. Extremely height fearful individuals (N = 110) participated in the study. Acrophobic symptoms were measured before and after 2 sessions of CBM-I and were compared to the standard treatment for acrophobia (exposure therapy), a combination of CBM-I and exposure therapy, and a Control condition. In line with hypotheses, participants in the 3 active conditions showed greater response to treatment than the Control condition in height-relevant interpretation bias, symptoms, and behavioral avoidance on a height stressor, with few differences between the active conditions. Further, symptom change was mediated by change in interpretation bias. Overall, findings suggest that different pathways to fear reduction (exposure vs. shifting interpretations) can lead to similar reductions in height fear. This study provides the first evidence that directly shifting cognitive processing, even with no therapist involvement, can reduce symptoms as effectively as the gold standard, therapist-directed exposure therapy. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  11. Growth evaluation: parent and child specific height standards.

    OpenAIRE

    Sorva, R; Tolppanen, E M; Lankinen, S; Perheentupa, J

    1989-01-01

    Data on the growth of 1063 children and their parents were analysed. Of the variation in height at prepuberty about 20%, and of the final height 30-46%, were explained by the variation in parental heights; the children's own height at the age of 1.0 year increased the proportion explained to half. Two equations were developed for increasing the accuracy of the evaluation of growth. One defines parent specific mean height standard deviation score, and the other includes the parents' heights an...

  12. On Typicality in Nonequilibrium Steady States

    Science.gov (United States)

    Evans, Denis J.; Williams, Stephen R.; Searles, Debra J.; Rondoni, Lamberto

    2016-08-01

    From the statistical mechanical viewpoint, relaxation of macroscopic systems and response theory rest on a notion of typicality, according to which the behavior of single macroscopic objects is given by appropriate ensembles: ensemble averages of observable quantities represent the measurements performed on single objects, because " almost all" objects share the same fate. In the case of non-dissipative dynamics and relaxation toward equilibrium states, " almost all" is referred to invariant probability distributions that are absolutely continuous with respect to the Lebesgue measure. In other words, the collection of initial micro-states (single systems) that do not follow the ensemble is supposed to constitute a set of vanishing, phase space volume. This approach is problematic in the case of dissipative dynamics and relaxation to nonequilibrium steady states, because the relevant invariant distributions attribute probability 1 to sets of zero volume, while evolution commonly begins in equilibrium states, i.e., in sets of full phase space volume. We consider the relaxation of classical, thermostatted particle systems to nonequilibrium steady states. We show that the dynamical condition known as Ω T-mixing is necessary and sufficient for relaxation of ensemble averages to steady state values. Moreover, we find that the condition known as weak T-mixing applied to smooth observables is sufficient for ensemble relaxation to be independent of the initial ensemble. Lastly, we show that weak T-mixing provides a notion of typicality for dissipative dynamics that is based on the (non-invariant) Lebesgue measure, and that we call physical ergodicity.

  13. When Walls are No Longer Barriers: Perception of Wall Height in Parkour

    OpenAIRE

    Taylor, J. Eric T.; Witt, Jessica; Sugovic, Mila

    2011-01-01

    Through training, skilled parkour athletes (traceurs) overcome everyday obstacles, such as walls, that are typically insurmountable. Traceurs and untrained novices estimated the height of walls and reported their anticipated ability to climb the wall. The traceurs perceived the walls as shorter than did novices. This result suggests that perception is scaled by the perceiver’s anticipated ability to act, and is consistent with the action-specific account of perception.

  14. Variation in height and knee height in adolescents in Merida, Mexico, by head of household employment level and family income.

    Science.gov (United States)

    Vázquez-Vázquez, Adriana; Azcorra, Hugo; Falfán, Ina; Dickinson, Federico

    2013-05-01

    Variation in height among young adults has been linked to the living conditions of different social groups. The aim of this study was to measure variation in the height and knee height of young adults by head of household employment level and family income. The sample comprised 180 individuals (90 girls) aged 16 and 17 years living in the city of Merida, Mexico. Height and knee height were measured by anthropometry, and individuals' family social and economic data collected from their mothers. Variation in these measurements was analysed by three categories of employment and family income terciles. One-way ANOVAs were done by sex to compare mean height and knee height by employment and family income. Coefficients of variation were calculated and a Bartlett test applied. Significant differences in height and knee height were observed only between family income terciles. Both sexes were taller at the highest levels of family income (p<0.05) and men had the highest (p<0.05) knee height. Highest family income individuals exhibited the least variation in height and knee height. Similarity in socioeconomic conditions for families in the lowest family income tercile and with employee heads of household was not associated with lower variation of height and knee height.

  15. Synthesizing Waves from Animated Height Fields

    DEFF Research Database (Denmark)

    Nielsen, Michael Bang; Söderström, Andreas; Bridson, Robert

    2013-01-01

    Computer animated ocean waves for feature films are typically carefully choreographed to match the vision of the director and to support the telling of the story. The rough shape of these waves is established in the previsualization (previs) stage, where artists use a variety of modeling tools...

  16. Extrapolating Satellite Winds to Turbine Operating Heights

    DEFF Research Database (Denmark)

    Badger, Merete; Pena Diaz, Alfredo; Hahmann, Andrea N.;

    2016-01-01

    Ocean wind retrievals from satellite sensors are typically performed for the standard level of 10 m. This restricts their full exploitation for wind energy planning, which requires wind information at much higher levels where wind turbines operate. A new method is presented for the vertical extra...

  17. Perching behaviour and perch height preference of laying hens in furnished cages varying in height.

    Science.gov (United States)

    Struelens, E; Tuyttens, F A M; Duchateau, L; Leroy, T; Cox, M; Vranken, E; Buyse, J; Zoons, J; Berckmans, D; Odberg, F; Sonck, B

    2008-07-01

    1. The objective was to investigate the effect of cage height on perch height preference and perching behaviour in laying hens. Twelve groups of two hens and 12 groups of 14 hens were tested in furnished cages equipped with two wooden perches. These stepwise perches were designed such that hens could choose between 7 different heights (6, 11, 16, 21, 26, 31 and 36 cm). Day- and night-time perching behaviour was observed on 4 consecutive days with a different cage height each day: 150, 55, 50 and 45 cm. 2. Given that a minimum perch-roof distance of 19 to 24 cm was available, hens preferred to roost on the highest perches at night. 3. Lowering cage height not only forced hens to use lower perches, but also reduced time spent on the perches during the day (two-hen and 14-hen test) and night (14-hen test). Moreover, it affected daytime behavioural activities (more standing and less preening) on the perches in the two-hen tests (but not in the 14-hen tests). 4. During the day lower perches were used more for standing and walking, higher perches more for sitting and sleeping. This behavioural differentiation was most pronounced in the highest cages. 5. Perch preference and perching behaviour depend on both the floor-perch distance and the perch-roof distance. Higher cages provide more opportunity for higher perches (which hens prefer), for better three-dimensional spacing (and consequently reduced density at floor level) and for behavioural differentiation according to perch height.

  18. Vowel category dependence of the relationship between palate height, tongue height, and oral area.

    Science.gov (United States)

    Hasegawa-Johnson, Mark; Pizza, Shamala; Alwan, Abeer; Cha, Jul Setsu; Haker, Katherine

    2003-06-01

    This article evaluates intertalker variance of oral area, logarithm of the oral area, tongue height, and formant frequencies as a function of vowel category. The data consist of coronal magnetic resonance imaging (MRI) sequences and acoustic recordings of 5 talkers, each producing 11 different vowels. Tongue height (left, right, and midsagittal), palate height, and oral area were measured in 3 coronal sections anterior to the oropharyngeal bend and were subjected to multivariate analysis of variance, variance ratio analysis, and regression analysis. The primary finding of this article is that oral area (between palate and tongue) showed less intertalker variance during production of vowels with an oral place of articulation (palatal and velar vowels) than during production of vowels with a uvular or pharyngeal place of articulation. Although oral area variance is place dependent, percentage variance (log area variance) is not place dependent. Midsagittal tongue height in the molar region was positively correlated with palate height during production of palatal vowels, but not during production of nonpalatal vowels. Taken together, these results suggest that small oral areas are characterized by relatively talker-independent vowel targets and that meeting these talker-independent targets is important enough that each talker adjusts his or her own tongue height to compensate for talker-dependent differences in constriction anatomy. Computer simulation results are presented to demonstrate that these results may be explained by an acoustic control strategy: When talkers with very different anatomical characteristics try to match talker-independent formant targets, the resulting area variances are minimized near the primary vocal tract constriction.

  19. Design and Test of Mixed-flow Impellers IV : Experimental Results for Impeller Models MFI-1 and MFI-2 with Changes in Blade Height

    Science.gov (United States)

    Hamrick, Joseph T; Beede, William L; Withee, Joseph R JR

    1954-01-01

    Modifications A and B of impeller model MFI-1 and A, B, and C of impeller model MFI-2 were investigated experimentally in an attempt to determine what allowance in blade height should be made for boundary layer and viscous losses in an impeller designed for isentropic compressible flow. A gradual increase in blade height was arbitrarily made from inlet to outlet in anticipation of a gradual build-up of boundary layer. Apparently there was a rapid build-up of boundary layer near the inlet in the experimental case rather than a gradual one. Therefore, the proper allowance for boundary layer cannot be described from the data obtained. Decreasing the pressure gradient along the shroud by reducing the blade height allowance apparently did little to increase the overall efficiency. At the design speed of 1400 feet per second, the overall adiabatic efficiency was increased from 0.83 for the MFI-1A to 0.85 for the MFI-1B with reduction in height; however, it is indicated from the theoretical velocity distribution and outlet surveys that the increase was due to a change from decelerating to accelerating flow along the hub rather than from any change along the shroud. It is further indicated that the consequences of a thickened or separated boundary layer depend not only on the design velocity gradients but also on the shape of the passage.

  20. Identifying the Functional Requirements for an Arizona Astronomy Data Hub (AADH)

    Science.gov (United States)

    Stahlman, G.; Heidorn, P. B.

    2015-12-01

    Astronomy data represent a curation challenge for information managers, as well as for astronomers. Extracting knowledge from these heterogeneous and complex datasets is particularly complicated and requires both interdisciplinary and domain expertise to accomplish true curation, with an overall goal of facilitating reproducible science through discoverability and persistence. A group of researchers and professional staff at the University of Arizona held several meetings during the spring of 2015 about astronomy data and the role of the university in curation of that data. The group decided that it was critical to obtain a broader consensus on the needs of the community. With assistance from a Start for Success grant provided by the University of Arizona Office of Research and Discovery and funding from the American Astronomical Society (AAS), a workshop was held in early July 2015, with 28 participants plus 4 organizers in attendance. Representing University researchers as well as astronomical facilities and a scholarly society, the group verified that indeed there is a problem with the long-term curation of some astronomical data not associated with major facilities, and that a repository or "data hub" with the correct functionality could facilitate research and the preservation and use of astronomy data. The workshop members also identified a set of next steps, including the identification of possible data and metadata to be included in the Hub. The participants further helped to identify additional information that must be gathered before construction of the AADH could begin, including identifying significant datasets that do not currently have sufficient preservation and dissemination infrastructure, as well as some data associated with journal publications and the broader context of the data beyond that directly published in the journals. Workshop participants recommended that a set of grant proposal should be developed that ensures community buy-in and