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Sample records for hsc70 focus formation

  1. Esophageal cancer alters the expression of nuclear pore complex binding protein Hsc70 and eIF5A-1.

    Science.gov (United States)

    Moghanibashi, Mehdi; Rastgar Jazii, Ferdous; Soheili, Zahra-Soheila; Zare, Maryam; Karkhane, Aliasghar; Parivar, Kazem; Mohamadynejad, Parisa

    2013-06-01

    Nuclear pore complex (NPC) is the only corridor for macromolecules exchange between nucleus and cytoplasm. NPC and its components, nucleoporins, play important role in the diverse physiological processes including macromolecule exchange, chromosome segregation, apoptosis and gene expression. Recent reports also suggest involvement of nucleoporins in carcinogenesis. Applying proteomics, we analyzed expression pattern of the NPC components in a newly established esophageal cancer cell line from Persia (Iran), the high-risk region for esophageal cancer. Our results indicate overexpression of Hsc70 and downregulation of subunit alpha type-3 of proteasome, calpain small subunit 1, and eIF5A-1. Among these proteins, Hsc70 and eIF5A-1 are in direct interaction with NPC and involved in the nucleocytoplasmic exchange. Hsc70 plays a critical role as a chaperone in the formation of a cargo-receptor complex in nucleocytoplasmic transport. On the other hand, it is an NPC-associated protein that binds to nucleoporins and contributes in recycling of the nucleocytoplasmic transport receptors in mammals and affects transport of proteins between nucleus and cytoplasm. The other nuclear pore interacting protein: eIF5A-1 binds to the several nucleoporins and participates in nucleocytoplasmic transport. Altered expression of Hsc70 and eIF5A-1 may cause defects in nucleocytoplasmic transport and play a role in esophageal carcinogenesis.

  2. Mitochondrial carrier protein biogenesis: role of the chaperones Hsc70 and Hsp90.

    Science.gov (United States)

    Zara, Vincenzo; Ferramosca, Alessandra; Robitaille-Foucher, Philippe; Palmieri, Ferdinando; Young, Jason C

    2009-04-15

    Metabolite carrier proteins of the mitochondrial inner membrane share homology in their transmembrane domains, which also carries their targeting information. In addition, some carriers have cleavable presequences which are not essential for targeting, but have some other function before import. The cytosolic chaperones Hsc70 (heat-shock cognate 70) and Hsp90 (heat-shock protein 90) complex with carrier precursors and interact specifically with the Tom (translocase of the mitochondrial outer membrane) 70 import receptor to promote import. We analysed how the presequences of the PiC (phosphate carrier) and CIC (citrate carrier) relate to the mechanisms of chaperone-mediated import. Deletion of the PiC presequence reduced the efficiency of import but, notably, not by causing aggregation. Instead, binding of the protein to Hsc70 was reduced, as well as the dependence on Hsc70 for import. Hsp90 binding and function in import was not greatly affected, but it could not entirely compensate for the lack of Hsc70 interaction. Deletion of the presequence from CIC was shown to cause its aggregation, but had little effect on the contribution to import of either Hsc70 or Hsp90. The presequence of PiC, but not that of CIC, conferred Hsc70 binding to dihydrofolate reductase fusion proteins. In comparison, OGC (oxoglutarate carrier) lacks a presequence and was more soluble, though it is still dependent on both Hsc70 and Hsp90. We propose that carrier presequences evolved to improve targeting competence by different mechanisms, depending on physical properties of the precursors in the cytosolic targeting environment.

  3. Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration.

    Science.gov (United States)

    Grifoni, Samira C; McKey, Susan E; Drummond, Heather A

    2008-05-01

    Recent studies suggest members of the degenerin (DEG)/epithelial Na(+) channel (ENaC)/acid-sensing ion channel (ASIC) protein family play an important role in vascular smooth muscle cell (VSMC) migration. In a previous investigation, we found suppression of a certain DEG/ENaC/ASIC member, ASIC2, increased VSMC chemotactic migration, raising the possibility that ASIC2 may play an inhibitory role. Because ASIC2 protein was retained in the cytoplasm, we reasoned increasing surface expression of ASIC2 might unmask the inhibitory role of ASIC2 in VSMC migration so we could test the hypothesis that ASIC2 inhibits VSMC migration. Therefore, we used the chemical chaperone glycerol to enhance ASIC2 expression. Glycerol 1) increased cytoplasm ASIC2 expression, 2) permitted detection of ASIC2 at the cell surface, and 3) inhibited platelet-derived growth factor (PDGF)-bb mediated VSMC migration. Furthermore, ASIC2 silencing completely abolished the inhibitory effect of glycerol on migration, suggesting upregulation of ASIC2 is responsible for glycerol-induced inhibition of VSMC migration. Because other investigators have shown that glycerol regulates ENaC/ASIC via interactions with a certain heat shock protein, heat shock protein 70 (Hsc70), we wanted to determine the importance of Hsc70 on ASIC2 expression in VSMCs. We found that Hsc70 silencing increases ASIC2 cell surface expression and inhibits VSMC migration, which is abolished by cosilencing ASIC2. These data demonstrate that Hsc70 inhibits ASIC2 expression, and, when the inhibitory effect of Hsc70 is removed, ASIC2 expression increases, resulting in reduced VSMC migration. Because VSMC migration contributes to vasculogenesis and remodeling following vascular injury, our findings raise the possibility that ASIC2-Hsc70 interactions may play a role in these processes.

  4. Hsc70 facilitates TGF-β-induced activation of Smad2/3 in fibroblastic NRK-49F cells

    Energy Technology Data Exchange (ETDEWEB)

    Ikezaki, Midori; Higashimoto, Natsuki; Matsumura, Ko; Ihara, Yoshito, E-mail: y-ihara@wakayama-med.ac.jp

    2016-08-26

    Heat-shock cognate protein 70 (Hsc70), a molecular chaperone constitutively expressed in the cell, is involved in the regulation of several cellular signaling pathways. In this study, we found that TGF-β-induced phosphorylation and nuclear translocation of Smad2/3 were suppressed in fibroblastic NRK-49F cells treated with small interfering RNA (siRNA) for Hsc70. In the cells underexpressing Hsc70, transcriptional induction of connective tissue growth factor (CTGF), a target gene of the TGF-β signaling, was also suppressed in the early phase of TGF-β stimulation. Upon stimulation with TGF-β, Hsc70 interacted with Smad2/3, suggesting functional interactions of Hsc70 and Smad2/3 for the activation of TGF-β-induced Smad signaling. Although the expression of heat-shock protein 70 (Hsp70) was upregulated in the cells treated with Hsc70 siRNA, TGF-β-induced Smad activation was not affected in the cells overexpressing Hsp70. Collectively, these results indicate that Hsc70, but not Hsp70, supportively regulates TGF-β-induced Smad signaling in NRK-49F cells. - Highlights: • Hsc70 siRNA treatment suppressed the expression of Hsc70 but induced the expression of Hsp70 in NRK-49F cells. • Hsc70 siRNA treatment suppressed the activation of Smad2/3 in the cells treated with TGF-β. • Hsc70 interacted with Smad2/3 on stimulation with TGF-β in the cells. • Hsp70 did not influence the TGF-β-induced activation of Smad2/3 in the cells overexpressing Hsp70.

  5. Quantitative analysis of the interplay between hsc70 and its co-chaperone HspBP1

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    Hicham Mahboubi

    2015-12-01

    Full Text Available Background. Chaperones and their co-factors are components of a cellular network; they collaborate to maintain proteostasis under normal and harmful conditions. In particular, hsp70 family members and their co-chaperones are essential to repair damaged proteins. Co-chaperones are present in different subcellular compartments, where they modulate chaperone activities.Methods and Results. Our studies assessed the relationship between hsc70 and its co-factor HspBP1 in human cancer cells. HspBP1 promotes nucleotide exchange on hsc70, but has also chaperone-independent functions. We characterized the interplay between hsc70 and HspBP1 by quantitative confocal microscopy combined with automated image analyses and statistical evaluation. Stress and the recovery from insult changed significantly the subcellular distribution of hsc70, but had little effect on HspBP1. Single-cell measurements and regression analysis revealed that the links between the chaperone and its co-factor relied on (i the physiological state of the cell and (ii the subcellular compartment. As such, we identified a linear relationship and strong correlation between hsc70 and HspBP1 distribution in control and heat-shocked cells; this correlation changed in a compartment-specific fashion during the recovery from stress. Furthermore, we uncovered significant stress-induced changes in the colocalization between hsc70 and HspBP1 in the nucleus and cytoplasm.Discussion. Our quantitative approach defined novel properties of the co-chaperone HspBP1 as they relate to its interplay with hsc70. We propose that changes in cell physiology promote chaperone redistribution and thereby stimulate chaperone-independent functions of HspBP1.

  6. Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes.

    Science.gov (United States)

    Iwasaki, Shintaro; Kobayashi, Maki; Yoda, Mayuko; Sakaguchi, Yuriko; Katsuma, Susumu; Suzuki, Tsutomu; Tomari, Yukihide

    2010-07-30

    Small silencing RNAs--small interfering RNAs (siRNAs) or microRNAs (miRNAs)--direct posttranscriptional gene silencing of their mRNA targets as guides for the RNA-induced silencing complex (RISC). Both siRNAs and miRNAs are born double stranded. Surprisingly, loading these small RNA duplexes into Argonaute proteins, the core components of RISC, requires ATP, whereas separating the two small RNA strands within Argonaute does not. Here we show that the Hsc70/Hsp90 chaperone machinery is required to load small RNA duplexes into Argonaute proteins, but not for subsequent strand separation or target cleavage. We envision that the chaperone machinery uses ATP and mediates a conformational opening of Ago proteins so that they can receive bulky small RNA duplexes. Our data suggest that the chaperone machinery may serve as the driving force for the RISC assembly pathway. Copyright 2010 Elsevier Inc. All rights reserved.

  7. Molecular cloning and expression of a heat-shock cognate 70 (hsc70) gene from swordtail fish ( Xiphophorus helleri)

    Science.gov (United States)

    Li, Ningqiu; Fu, Xiaozhe; Han, Jingang; Shi, Cunbin; Huang, Zhibin; Wu, Shuqin

    2013-07-01

    Heat shock proteins are a family of molecular chaperones that are involved in many aspects of protein homeostasis. In the present study, a full-length cDNA, encoding the constitutively expressed 70-kDa heat shock cognate protein (Hsc70), was isolated from swordtail fish ( Xiphophorus helleri) and designated as XheHsc70. The Xhehsc70 cDNA was 2 104 bp long with an open reading frame of 1 941 bp, and it encoded a protein of 646 amino acids with a theoretical molecular weight of 70.77 kDa and an isoelectric point of 5.04. The deduced amino acid sequence shared 94.1%-98.6% identities with the Hsc70s from a number of other fish species. Tissue distribution results show that the Xhehsc70 mRNA was expressed in brain, heart, head kidney, kidney, spleen, liver, muscle, gill, and peripheral blood. After immunization with formalin-killed Vibrio alginolyticus cells there was a significant increase in the Xhehsc70 mRNA transcriptional level in the head kidney of the vaccinated fish compared with in the control at 6, 12, 24, and 48 h as shown by quantitative real time RT-PCR. Based on an analysis of the amino acid sequence of XheHsc70, its phylogeny, and Xhehsc70 mRNA expression, XheHsc70 was identified as a member of the cytoplasmic Hsc70 (constitutive) subfamily of the Hsp70 family of heat shock proteins, suggesting that it may play a role in the immune response. The Xhehsc70 cDNA sequence reported in this study was submitted to GenBank under the accession number JF739182.

  8. The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel.

    Science.gov (United States)

    Iftinca, Mircea; Flynn, Robyn; Basso, Lilian; Melo, Helvira; Aboushousha, Reem; Taylor, Lauren; Altier, Christophe

    2016-01-01

    Specialized cellular defense mechanisms prevent damage from chemical, biological, and physical hazards. The heat shock proteins have been recognized as key chaperones that maintain cell survival against a variety of exogenous and endogenous stress signals including noxious temperature. However, the role of heat shock proteins in nociception remains poorly understood. We carried out an expression analysis of the constitutively expressed 70 kDa heat-shock cognate protein, a member of the stress-induced HSP70 family in lumbar dorsal root ganglia from a mouse model of Complete Freund's Adjuvant-induced chronic inflammatory pain. We used immunolabeling of dorsal root ganglion neurons, behavioral analysis and patch clamp electrophysiology in both dorsal root ganglion neurons and HEK cells transfected with Hsc70 and Transient Receptor Potential Channels to examine their functional interaction in heat shock stress condition. We report an increase in protein levels of Hsc70 in mouse dorsal root ganglia, 3 days post Complete Freund's Adjuvant injection in the hind paw. Immunostaining of Hsc70 was observed in most of the dorsal root ganglion neurons, including the small size nociceptors immunoreactive to the TRPV1 channel. Standard whole-cell patch-clamp technique was used to record Transient Receptor Potential Vanilloid type 1 current after exposure to heat shock. We found that capsaicin-evoked currents are inhibited by heat shock in dorsal root ganglion neurons and transfected HEK cells expressing Hsc70 and TRPV1. Blocking Hsc70 with matrine or spergualin compounds prevented heat shock-induced inhibition of the channel. We also found that, in contrast to TRPV1, both the cold sensor channels TRPA1 and TRPM8 were unresponsive to heat shock stress. Finally, we show that inhibition of TRPV1 depends on the ATPase activity of Hsc70 and involves the rho-associated protein kinase. Our work identified Hsc70 and its ATPase activity as a central cofactor of TRPV1 channel function

  9. Dual Role for Hsc70 in the Biogenesis and Regulation of the Heme-Regulated Kinase of the α Subunit of Eukaryotic Translation Initiation Factor 2

    Science.gov (United States)

    Uma, Sheri; Thulasiraman, Vanitha; Matts, Robert L.

    1999-01-01

    The heme-regulated kinase of the α subunit of eukaryotic initiation factor 2 (HRI) is activated in rabbit reticulocyte lysate (RRL) in response to a number of environmental conditions, including heme deficiency, heat shock, and oxidative stress. Activation of HRI causes an arrest of initiation of protein synthesis. Recently, we have demonstrated that the heat shock cognate protein Hsc70 negatively modulates the activation of HRI in RRL in response to these environmental conditions. Hsc70 is also known to be a critical component of the Hsp90 chaperone machinery in RRL, which plays an obligatory role for HRI to acquire and maintain a conformation that is competent to activate. Using de novo-synthesized HRI in synchronized pulse-chase translations, we have examined the role of Hsc70 in the regulation of HRI biogenesis and activation. Like Hsp90, Hsc70 interacted with nascent HRI and HRI that was matured to a state which was competent to undergo stimulus-induced activation (mature-competent HRI). Interaction of HRI with Hsc70 was required for the transformation of HRI, as the Hsc70 antagonist clofibric acid inhibited the folding of HRI into a mature-competent conformation. Unlike Hsp90, Hsc70 also interacted with transformed HRI. Clofibric acid disrupted the interaction of Hsc70 with transformed HRI that had been matured and transformed in the absence of the drug. Disruption of Hsc70 interaction with transformed HRI in heme-deficient RRL resulted in its hyperactivation. Furthermore, activation of HRI in response to heat shock or denatured proteins also resulted in a similar blockage of Hsc70 interaction with transformed HRI. These results indicate that Hsc70 is required for the folding and transformation of HRI into an active kinase but is subsequently required to negatively attenuate the activation of transformed HRI. PMID:10454533

  10. 70-kDa Heat Shock Cognate Protein hsc70 Mediates Calmodulin-dependent Nuclear Import of the Sex-determining Factor SRY*

    Science.gov (United States)

    Kaur, Gurpreet; Lieu, Kim G.; Jans, David A.

    2013-01-01

    We recently showed that the developmentally important family of SOX (SRY (sex determining region on the Y chromosome)-related high mobility group (HMG) box) proteins require the calcium-binding protein calmodulin (CaM) for optimal nuclear accumulation, with clinical mutations in SRY that specifically impair nuclear accumulation via this pathway resulting in XY sex reversal. However, the mechanism by which CaM facilitates nuclear accumulation is unknown. Here, we show, for the first time, that the 70-kDa heat shock cognate protein hsc70 plays a key role in CaM-dependent nuclear import of SRY. Using a reconstituted nuclear import assay, we show that antibodies to hsc70 significantly reduce nuclear accumulation of wild type SRY and mutant derivatives thereof that retain CaM-dependent nuclear import, with an increased rate of nuclear accumulation upon addition of both CaM and hsc70, in contrast to an SRY mutant derivative with impaired CaM binding. siRNA knockdown of hsc70 in intact cells showed similar results, indicating clear dependence upon hsc70 for CaM-dependent nuclear import. Analysis using the technique of fluorescence recovery after photobleaching indicated that hsc70 is required for the maximal rate of SRY nuclear import in living cells but has no impact upon SRY nuclear retention/nuclear dynamics. Finally, we demonstrate direct binding of hsc70 to the SRY·CaM complex, with immunoprecipitation experiments from cell extracts showing association of hsc70 with wild type SRY, but not with a mutant derivative with impaired CaM binding, dependent on Ca2+. Our novel findings strongly implicate hsc70 in CaM-dependent nuclear import of SRY. PMID:23235156

  11. Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.

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    Jun-Yi Zhu

    Full Text Available Mortalin is an essential component of the molecular machinery that imports nuclear-encoded proteins into mitochondria, assists in their folding, and protects against damage upon accumulation of dysfunctional, unfolded proteins in aging mitochondria. Mortalin dysfunction associated with Parkinson's disease (PD increases the vulnerability of cultured cells to proteolytic stress and leads to changes in mitochondrial function and morphology. To date, Drosophila melanogaster has been successfully used to investigate pathogenesis following the loss of several other PD-associated genes. We generated the first loss-of-Hsc70-5/mortalin-function Drosophila model. The reduction of Mortalin expression recapitulates some of the defects observed in the existing Drosophila PD-models, which include reduced ATP levels, abnormal wing posture, shortened life span, and reduced spontaneous locomotor and climbing ability. Dopaminergic neurons seem to be more sensitive to the loss of mortalin than other neuronal sub-types and non-neuronal tissues. The loss of synaptic mitochondria is an early pathological change that might cause later degenerative events. It precedes both behavioral abnormalities and structural changes at the neuromuscular junction (NMJ of mortalin-knockdown larvae that exhibit increased mitochondrial fragmentation. Autophagy is concomitantly up-regulated, suggesting that mitochondria are degraded via mitophagy. Ex vivo data from human fibroblasts identifies increased mitophagy as an early pathological change that precedes apoptosis. Given the specificity of the observed defects, we are confident that the loss-of-mortalin model presented in this study will be useful for further dissection of the complex network of pathways that underlie the development of mitochondrial parkinsonism.

  12. Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer

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    Patani Neill

    2010-01-01

    Full Text Available Background: Ubiquitin modification of proteins influences cellular processes relevant to carcinogenesis. CHIP (carboxyl-terminus of Hsc70-interacting protein is a chaperone-dependent E3 ubiquitin ligase, regulating the stability of heat shock protein 90 (HSP90 interacting proteins. CHIP is implicated in the modulation of estrogen receptor (ESR1 and Her-2/neu (ERBB2 stability. LOX (lysyl-oxidase serves intracellular roles and catalyses the cross-linking of extracellular matrix (ECM collagens and elastin. LOX expression is altered in human malignancies and their peri-tumoral stroma. However, paradoxical roles are reported. In this study, the level of mRNA expression of CHIP and LOX were assessed in normal and malignant breast tissue and correlated with clinico-pathological parameters. Materials and Methods: Breast cancer (BC tissues (n = 127 and normal tissues (n = 33 underwent RNA extraction and reverse transcription; transcript levels were determined using real-time quantitative PCR and normalized against CK-19. Transcript levels were analyzed against TNM stage, nodal involvement, tumor grade and clinical outcome over a ten-year follow-up period. Results: CHIP expression decreased with increasing Nottingham Prognostic Index (NPI: NPI-1 vs. NPI-3 (12.2 vs. 0.2, P = 0.0264, NPI-2 vs. NPI-3 (3 vs. 0.2, P = 0.0275. CHIP expression decreased with increasing TNM stage: TNM-1 vs. TNM-2 (12 vs. 0, P = 0.0639, TNM-1 vs. TNM-2-4 (12 vs. 0, P = 0.0434. Lower transcript levels were associated with increasing tumor grade: grade 1 vs. grade 3 (17.7 vs. 0.3, P = 0.0266, grade 2 vs. grade 3 (5 vs. 0.3, P = 0.0454. The overall survival (OS for tumors classified as ′low-level expression′, was poorer than those with ′high-level expression′ (118.1 vs. 152.3 months, P = 0.039. LOX expression decreased with increasing NPI: NPI-1 vs. NPI-2 (3 vs. 0, P = 0.0301 and TNM stage: TNM-1 = 3854639, TNM-2 = 908900, TNM-3 = 329, TNM-4 = 1.232 (P = NS. Conclusion: CHIP

  13. Interacciones de las proteínas disulfuro isomerasa y de choque térmico Hsc70 con proteínas estructurales recombinantes purificadas de rotavirus

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    Luz Y. Moreno

    2016-01-01

    Full Text Available Introducción. La entrada de rotavirus a las células parece estar mediado por interacciones secuenciales entre las proteínas estructurales virales y algunas moléculas de la superficie celular. Sin embargo, los mecanismos por los cuales el rotavirus infecta la célula diana aún no se comprenden bien. Existe alguna evidencia que muestra que las proteínas estructurales de rotavirus VP5* y VP8* interactúan con algunas moléculas de la superficie celular. La disponibilidad de las proteínas estructurales de rotavirus recombinantes en cantidad suficiente se ha convertido en un aspecto importante para la identificación de las interacciones específicas de los receptores virus-célula durante los eventos tempranos del proceso infeccioso. Objetivo. El propósito del presente trabajo es realizar un análisis de las interacciones entre las proteínas estructurales de rotavirus recombinante VP5*, VP8* y VP6, y las proteínas celulares Hsc70 y PDI utilizando sus versiones recombinantes purificadas. Materiales y métodos. Las proteínas recombinantes de rotavirus VP5* y VP8* y las proteínas recombinantes celulares Hsc70 y PDI se expresaron en E. coli BL21 (DE3, mientras que VP6 se expresó en células MA104 con virus vaccinia recombinante transfectada. La interacción entre el rotavirus y las proteínas celulares se estudió mediante ELISA, co-inmunoprecipitación y SDS-PAGE/ Western. Resultados. Las condiciones óptimas para la expresión de proteínas recombinantes se determinaron y se generaron anticuerpos contra ellas. Los resultados sugirieron que las proteínas virales rVP5* y rVP6 interactúan con Hsc70 y PDI in vitro. También se encontró que éstas proteínas virales recombinantes interactúan con Hsc70 en las balsas lipídicas (“Rafts” en un cultivo celular. El tratamiento de las células, ya sea con DLP o rVP6 produjo significativamente la inhibición de la infección por rotavirus. Conclusión. Los resultados permiten concluir que r

  14. Expression levels of hsc70 and hsp60 are developmentally regulated during B-cell maturation and not associated to childhood c-ALL at presentation or relapse

    DEFF Research Database (Denmark)

    Wehner, Peder Skov; Nielsen, Bendt; Hokland, Marianne

    2003-01-01

    ) or heat shock protein 60 (hsp60) contribute to B-cell differentiation and leukemogenesis. We compared the expression of these hsps in normal peripheral blood (PB) CD19+ B-cells, in pediatric bone marrow (BM) CD19+ CD10+ B-cell precursors (BCPs) from normal donors, and in BCPs from common acute......Heat shock proteins are potent regulators of apoptosis, and so they may also be involved in normal cellular differentiation and cancerogenesis. We used quantitative two-dimensional gel electrophoresis for determining whether either the constitutive chaperonic heat shock cognate protein 70 (hsc70...

  15. Producción de la proteína de choque térmico HSC70 Recombinante en Escherichia Coli BL21 (DE3 para generar anticuerpos policlonales

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    Rocio Cely Castro

    2006-07-01

    Full Text Available Antecedentes. Los organismos vivos responden al estrés aumentando la síntesis de proteínas. El estrés por choque térmico ha sido el más estudiado y las proteínas que se inducen, se han denominado genéricamente como proteínas de choque térmico. Objetivo.En este trabajo se establecieron las condiciones óptimas de producción de la proteína HSC70, expresada en E.coli BL21 (DE3 y de los anticuerpos policlonales que permitan identificarla. Material y métodos. Mediante varios ensayos se establecieron las concentraciones óptimas del agente inductor isopropil- -D-thiogalacto­piranosido (PTG, del inóculo bacteriano, de empleo de los plásmidos de expresión pET-3a y pET-28a (+; y el método más eficiente para la recuperación de las formas soluble o insoluble de la proteína y de anticuerpos policlonales que la identifiquen. Resultados. Encontramos que el inóculo de cinco colonias con IPTG (2mM en tubos con cinco mililitros de medio modificado e incubadas por 24 horas a 37°C con agitación constante (200 r.p.m y tratamiento de sonicación, produce el mejor rendimiento de HSC70. La calidad de la proteína inducida se estableció mediante "Western blotting". Conclusión. La proteína recombinante así obtenida permitió, generar anticuerpos policlonales que a su vez permiten detectar la proteína HSC70 natural en la membrana citoplasmática de diferentes células por inmunofluorescencia, en ELISA, en Western Blot y en pruebas de bloqueo de infección de rotavirus.

  16. FOCUS AND CONSTITUENT QUESTION FORMATION IN DAGBANI

    African Journals Online (AJOL)

    Issah

    Key words: SpecFoc, focus marker, clause initial, constituent interrogatives, information ... 1Throughout this work, I use the phrase interrogative words in a general way to refer to the ...... Wh-Questions and extraction asymmetries in Malagasy.

  17. Focus on the post-DVD formats

    Science.gov (United States)

    He, Hong; Wei, Jingsong

    2005-09-01

    As the digital TV(DTV) technologies are developing rapidly on its standard system, hardware desktop, software model, and interfaces between DTV and the home net, High Definition TV (HDTV) program worldwide broadcasting is scheduled. Enjoying high quality TV program at home is not a far-off dream for people. As for the main recording media, what would the main stream be for the optical storage technology to meet the HDTV requirements is becoming a great concern. At present, there are a few kinds of Post-DVD formats which are competing on technology, standard and market. Here we give a review on the co-existing Post-DVD formats in the world. We will discuss on the basic parameters for optical disk, video /audio coding strategy and system performance for HDTV program.

  18. The impact of affective and cognitive focus on attitude formation

    NARCIS (Netherlands)

    Berg, H. van den; Manstead, A.S.R.; Pligt, J. van der; Wigboldus, D.H.J.

    2006-01-01

    We examined the effects of unobtrusive affective and cognitive focus on attitude formation. To induce focus, participants worked on a word-search puzzle consisting of either affective (e.g., emotion) or cognitive (e.g., reasoning) words. They then read positive and negative affective and cognitive

  19. Question Formation and Focus Construction in Owo: A Yoruba Dialect

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    Boluwaji Oshodi

    2016-06-01

    Full Text Available Question formation and focusing are two transformational processes attested in Standard Yorùbá both of which have been extensively discussed in previous studies. However, very little is known about these concepts in Owo (Owò̩̩̀ a south-East Yoruba (Yorùbá dialect. This study examines the concept of questions and focusing in Owo ̩̩̀̀dialect with a comparison of the processes in Standard Yorùbá. The study revealed some differences as well as similarities in the two processes in Owo ̩̩̀̀and standard Yorùbá. Just like in Standard Yorùbá, question markers in Owo ̩̩̀̀normally occur in sentence initial and final positions. However, the question marker de ̩̀constantly appears sentence medially before and before verbs in certain constructions. Furthermore, while the focus marker in Yorùbá normally occurs immediately after the focused item with a stable form, the focus marker in Owo ̩̩̀̀usually occurs at the sentence final position as a reduplicated form of the last syllable of the final item. Also, a pronoun which indicates number and agreement usually occurs immediately after the focused item in Owò̩̩̀. Finally, just like in Yorùbá, there is a syntactic relationship between question and focusing in Owo ̩̩̀̀dialect.

  20. In situ hydride formation in titanium during focused ion milling.

    Science.gov (United States)

    Ding, Rengen; Jones, Ian P

    2011-01-01

    It is well known that titanium and its alloys are sensitive to electrolytes and thus hydrides are commonly observed in electropolished foils. In this study, focused ion beam (FIB) milling was used to prepare thin foils of titanium and its alloys for transmission electron microscopy. The results show the following: (i) titanium hydrides were observed in pure titanium, (ii) the preparation of a bulk sample in water or acid solution resulted in the formation of more hydrides and (iii) FIB milling aids the precipitation of hydrides, but there were never any hydrides in Ti64 and Ti5553.

  1. Optimization of sources for focusing wave energy in targeted formations

    KAUST Repository

    Jeong, C

    2010-06-08

    We discuss a numerical approach for identifying the surface excitation that is necessary to maximize the response of a targeted subsurface formation. The motivation stems from observations in the aftermath of earthquakes, and from limited field experiments, whereby increased oil production rates were recorded and were solely attributable to the induced reservoir shaking. The observations suggest that focusing wave energy to the reservoir could serve as an effective low-cost enhanced oil recovery method. In this paper, we report on a general method that allows the determination of the source excitation, when provided with a desired maximization outcome at the targeted formation. We discuss, for example, how to construct the excitation that will maximize the kinetic energy in the target zone, while keeping silent the neighbouring zones. To this end, we cast the problem as an inverse-source problem, and use a partial-differential- equation-constrained optimization approach to arrive at an optimized source signal. We seek to satisfy stationarity of an augmented functional, which formally leads to a triplet of state, adjoint and control problems. We use finite elements to resolve the state and adjoint problems, and an iterative scheme to satisfy the control problem to converge to the sought source signal. We report on one-dimensional numerical experiments in the time domain involving a layered medium of semi-infinite extent. The numerical results show that the targeted formation\\'s kinetic energy resulting from an optimized wave source could be several times greater than the one resulting from a blind source choice, and could overcome the mobility threshold of entrapped reservoir oil. © 2010 Nanjing Geophysical Research Institute.

  2. Optimization of sources for focusing wave energy in targeted formations

    International Nuclear Information System (INIS)

    Jeong, C; Kallivokas, L F; Huh, C; Lake, L W

    2010-01-01

    We discuss a numerical approach for identifying the surface excitation that is necessary to maximize the response of a targeted subsurface formation. The motivation stems from observations in the aftermath of earthquakes, and from limited field experiments, whereby increased oil production rates were recorded and were solely attributable to the induced reservoir shaking. The observations suggest that focusing wave energy to the reservoir could serve as an effective low-cost enhanced oil recovery method. In this paper, we report on a general method that allows the determination of the source excitation, when provided with a desired maximization outcome at the targeted formation. We discuss, for example, how to construct the excitation that will maximize the kinetic energy in the target zone, while keeping silent the neighbouring zones. To this end, we cast the problem as an inverse-source problem, and use a partial-differential-equation-constrained optimization approach to arrive at an optimized source signal. We seek to satisfy stationarity of an augmented functional, which formally leads to a triplet of state, adjoint and control problems. We use finite elements to resolve the state and adjoint problems, and an iterative scheme to satisfy the control problem to converge to the sought source signal. We report on one-dimensional numerical experiments in the time domain involving a layered medium of semi-infinite extent. The numerical results show that the targeted formation's kinetic energy resulting from an optimized wave source could be several times greater than the one resulting from a blind source choice, and could overcome the mobility threshold of entrapped reservoir oil

  3. Wave energy focusing to subsurface poroelastic formations to promote oil mobilization

    KAUST Repository

    Karve, P. M.; Kallivokas, L. F.

    2015-01-01

    We discuss an inverse source formulation aimed at focusing wave energy produced by ground surface sources to target subsurface poroelastic formations. The intent of the focusing is to facilitate or enhance the mobility of oil entrapped within

  4. FORMATION INNOVATIVELY FOCUSED INFRASTRUCTURE OF THE GRAIN MARKET

    Directory of Open Access Journals (Sweden)

    D. S. Latynin

    2014-01-01

    Full Text Available Summary. The perspective scheme of infrastructure of the modern grain market is directed on perfection merchandising grains by means of liquidation of is material disproportions between its participants for decrease in logistical costs counting upon 1 t grains, and creations of the alternative organized channel merchandising, providing a direct output on the wholesale market of direct commodity producers of grain and their participation in distribution of profit received from export. Elimination of is material disproportions on all circuit passage of grain from the supplier of production up to the end user is necessary for connecting with the organization merchandising on principles of logistics. It will allow to ensure the general synergistic effect exceeding total effect at separate participants of a circuit. The structure of Association participants of the grain market, is directed on creation mutual interest by a deepening specialization of each participant merchandising, consolidations of their investment resources to development of this circuit, to decrease in logistical costs. Feature of the modern period functioning of the grain market is necessity acceleration of scientific and technical progress on the basis of innovative processes. Innovative activity causes necessity of faster development of an infrastructure of the grain market. One directions promotion of innovations is development in region techno park formations. Their advantage consists in an opportunity initiators of new technologies independently to carry out their scientific and design development and to advance a grain husbandry through commercialization and a transfer. With a view modernization of a regional infrastructure of the grain market in modern conditions creation electronic trading platform, introduction system of electronic commerce is extremely actual. By means of electronic technologies economic attitudes in the market essentially change, giving to them scale

  5. Focusing on clay formation as host media of HLW geological disposal in China

    International Nuclear Information System (INIS)

    Zheng Hualing; Chen Shi; Sun Donghui

    2007-01-01

    Host medium is vitally important for safety for HLW geological disposal. Chinese HLW disposal effort in the past decades were mainly focused on granite formation. However, the granite formation has fatal disadvantage for HLW geological disposal. This paper reviews experiences gained and lessons learned in the international community and analyzes key factors affecting the site selection. It is recommended that clay formation should be taken into consideration and additional effort should be made before decision making of host media of HLW disposal in China. (authors)

  6. Bragging on Facebook: The Interaction of Content Source and Focus in Online Impression Formation.

    Science.gov (United States)

    Scott, Graham G; Ravenscroft, Kirsty

    2017-01-01

    Warranting Theory proposes that third-party testimonials are more influential in online impression formation than target-authored statements. Individuals posting content on social media accurately convey their offline personality while endeavoring to present themselves in a positive light. In doing so, they may misjudge the psychological distance of the majority of viewers, who could view this positive self-presentation as bragging and form resultant negative impressions. In this study, we asked 136 participants to view the Facebook timelines of four female targets. Timeline content varied by source (owner- vs. friend-authored) and focus (generally positive vs. personally positive). Participants were tasked with forming impressions of targets and rating them based on attractiveness, confidence, modesty, and popularity. We found that source and focus played distinct roles in impression formation. More positive impressions were formed when owner-authored content was general, and when friend-authored content was personal. This highlights the role played by content focus in impression formation, and the potentially damaging effect of perceived bragging. These results are discussed in relation to the application of the Warranting Theory of impression formation online, and discrepancies between these results and those from related articles are examined.

  7. [A NATURAL PLAGUE FOCUS. IN GORNYI ALTAI: FORMATION, DEVELOPMENT, AND FUNCTIONING].

    Science.gov (United States)

    Korzun, V M; Balakhoiov, S V; Chpanin, E V; Denisov, A V; Mikhailov, E P; Mischenko, A J; Yarygina, M B; Rozhdestvensky, E N; Fomina, L A

    2016-01-01

    The paper gives the results of analyzing the data of long-term studies of the natural focal pattern of plague in the Gornyi Altai natural focus. It describes a wide range of biological processes occurring in the focus and shows the most important patterns of its functioning as a complex multilevel ecological system. The key features of the formation of the focus have been revealed. The plague focus in South-Western Altai has formed relatively, recently, about half a century ago, then it has intensively developed and its enzootic area and the activity of epizootic manifestations have considerably increased. This process is due to the space-time transformations of the basic ecological and population characteristics of Pallas' pika (Ochotoma pallasi), the principal vector of the pathogen of plague and fleas parasitizing the mammal, which is in turn related to the aridization of mountain steppes in South-Western Altai.

  8. Focus on Formative Feedback communication and self-regulated learning – a study in compulsory schools

    DEFF Research Database (Denmark)

    Kirkegaard, Preben Olund

    This study addresses the conceptual challenge of providing students in compulsory schools with good quality formative feedback to enhance self-regulated learning in social interactions. Resent educational research indicates that social communicative interactions in the classroom, with a focus...... qualitative data from video recorded teaching sessions and student group interviews. Methodologically we are inspired by the ethnographical classroom research method. The empirical basis for studying these aspects is data from two compulsory schools in Denmark. This study is a work in progress. Our findings...... on formative feedback, hold the potential to enhance students learning. Self-regulated learning is highly pertinent and can be seen as one of the most import skills for the 21st century learner. We argue that formative feedbackcommunication in interactions is crucial for students to develop self...

  9. Wave energy focusing to subsurface poroelastic formations to promote oil mobilization

    KAUST Repository

    Karve, P. M.

    2015-04-22

    We discuss an inverse source formulation aimed at focusing wave energy produced by ground surface sources to target subsurface poroelastic formations. The intent of the focusing is to facilitate or enhance the mobility of oil entrapped within the target formation. The underlying forward wave propagation problem is cast in two spatial dimensions for a heterogeneous poroelastic target embedded within a heterogeneous elastic semi-infinite host. The semi-infiniteness of the elastic host is simulated by augmenting the (finite) computational domain with a buffer of perfectly matched layers. The inverse source algorithm is based on a systematic framework of partial-differential-equation-constrained optimization. It is demonstrated, via numerical experiments, that the algorithm is capable of converging to the spatial and temporal characteristics of surface loads that maximize energy delivery to the target formation. Consequently, the methodology is well-suited for designing field implementations that could meet a desired oil mobility threshold. Even though the methodology, and the results presented herein are in two dimensions, extensions to three dimensions are straightforward.

  10. Capillary isoelectric focusing--useful tool for detection of the biofilm formation in Staphylococcus epidermidis.

    Science.gov (United States)

    Ruzicka, Filip; Horka, Marie; Hola, Veronika; Votava, Miroslav

    2007-03-01

    The biofilm formation is an important factor of S. epidermidis virulence. Biofilm-positive strains might be clinically more important than biofilm-negative ones. Unlike biofilm-negative staphylococci, biofilm-positive staphylococci are surrounded with an extracellular polysaccharide substance. The presence of this substance on the surface can affect physico-chemical properties of the bacterial cell, including surface charge. 73 S. epidermidis strains were examined for the presence of ica operon, for the ability to form biofilm by Christensen test tube method and for the production of slime by Congo red agar method. Isoelectric points (pI) of these strains were determined by means of Capillary Isoelectric Focusing. The biofilm negative strains focused near pI value 2.3, while the pI values of the biofilm positive strains were near 2.6. Isoelectric point is a useful criterion for the differentiation between biofilm-positive and biofilm-negative S. epidermidis strains.

  11. Formation of plasma channels in air under filamentation of focused ultrashort laser pulses

    International Nuclear Information System (INIS)

    Ionin, A A; Seleznev, L V; Sunchugasheva, E S

    2015-01-01

    The formation of plasma channels in air under filamentation of focused ultrashort laser pulses was experimentally and theoretically studied together with theoreticians of the Moscow State University and the Institute of Atmospheric Optics. The influence of various characteristics of ultrashort laser pulses on these plasma channels is discussed. Plasma channels formed under filamentation of focused laser beams with a wavefront distorted by spherical aberration (introduced by adaptive optics) and by astigmatism, with cross-section spatially formed by various diaphragms and with different UV and IR wavelengths, were experimentally and numerically studied. The influence of plasma channels created by a filament of a focused UV or IR femtosecond laser pulse (λ = 248 nm or 740 nm) on characteristics of other plasma channels formed by a femtosecond pulse at the same wavelength following the first one with varied nanosecond time delay was also experimentally studied. An application of plasma channels formed due to the filamentation of focused UV ultrashort laser pulses including a train of such pulses and a combination of ultrashort and long (∼100 ns) laser pulses for triggering and guiding long (∼1 m) electric discharges is discussed. (topical review)

  12. Experimentally validated multiphysics computational model of focusing and shock wave formation in an electromagnetic lithotripter.

    Science.gov (United States)

    Fovargue, Daniel E; Mitran, Sorin; Smith, Nathan B; Sankin, Georgy N; Simmons, Walter N; Zhong, Pei

    2013-08-01

    A multiphysics computational model of the focusing of an acoustic pulse and subsequent shock wave formation that occurs during extracorporeal shock wave lithotripsy is presented. In the electromagnetic lithotripter modeled in this work the focusing is achieved via a polystyrene acoustic lens. The transition of the acoustic pulse through the solid lens is modeled by the linear elasticity equations and the subsequent shock wave formation in water is modeled by the Euler equations with a Tait equation of state. Both sets of equations are solved simultaneously in subsets of a single computational domain within the BEARCLAW framework which uses a finite-volume Riemann solver approach. This model is first validated against experimental measurements with a standard (or original) lens design. The model is then used to successfully predict the effects of a lens modification in the form of an annular ring cut. A second model which includes a kidney stone simulant in the domain is also presented. Within the stone the linear elasticity equations incorporate a simple damage model.

  13. Impact of cavitation on lesion formation induced by high intensity focused ultrasound

    International Nuclear Information System (INIS)

    Fan Pengfei; Jie Yu; Yang Xin; Tu Juan; Guo Xiasheng; Zhang Dong; Huang Pintong

    2017-01-01

    High intensity focused ultrasound (HIFU) has shown a great promise in noninvasive cancer therapy. The impact of acoustic cavitation on the lesion formation induced by HIFU is investigated both experimentally and theoretically in transparent protein-containing gel and ex vivo liver tissue samples. A numerical model that accounts for nonlinear acoustic propagation and heat transfer is used to simulate the lesion formation induced by the thermal effect. The results showed that lesions could be induced in the samples exposed to HIFU with various acoustic pressures and pulse lengths. The measured areas of lesions formed in the lateral direction were comparable to the simulated results, while much larger discrepancy was observed between the experimental and simulated data for the areas of longitudinal lesion cross-section. Meanwhile, a series of stripe-wiped-off B-mode pictures were obtained by using a special imaging processing method so that HIFU-induced cavitation bubble activities could be monitored in real-time and quantitatively analyzed as the functions of acoustic pressure and pulse length. The results indicated that, unlike the lateral area of HIFU-induced lesion that was less affected by the cavitation activity, the longitudinal cross-section of HIFU-induced lesion was significantly influenced by the generation of cavitation bubbles through the temperature elevation resulting from HIFU exposures. Therefore, considering the clinical safety in HIFU treatments, more attention should be paid on the lesion formation in the longitudinal direction to avoid uncontrollable variation resulting from HIFU-induced cavitation activity. (paper)

  14. Electromagnetic particle in cell modeling of the plasma focus: Current sheath formation and lift off

    International Nuclear Information System (INIS)

    Seng, Y. S.; Lee, P.; Rawat, R. S.

    2014-01-01

    The shaping and formation of the current sheath takes place in the breakdown phase of a plasma focus device and critically controls the device performance. Electrostatic particle in cell codes, with magnetic effects ignored, have been used to model the breakdown phase. This Letter reports the successful development and implementation of an electromagnetic particle in cell (EMPIC) code, including magnetic effects self-consistently, to simulate the breakdown phase; from the ionization, localization and gliding discharge along the insulator to the time instant of current sheath lift off. The magnetic field was found to be appreciable from the time the current sheath came into contact with the anode with increased local current, initiating the voltage breakdown of the device as a result

  15. Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation.

    Science.gov (United States)

    Takeuchi, Shinji; Fukuda, Koji; Yamada, Tadaaki; Arai, Sachiko; Takagi, Satoshi; Ishii, Genichiro; Ochiai, Atsushi; Iwakiri, Shotaro; Itoi, Kazumi; Uehara, Hisanori; Nishihara, Hiroshi; Fujita, Naoya; Yano, Seiji

    2017-04-01

    Malignant pleural mesothelioma (MPM) is characterized by dissemination and aggressive growth in the thoracic cavity. Podoplanin (PDPN) is an established diagnostic marker for MPM, but the function of PDPN in MPM is not fully understood. The purpose of this study was to determine the pathogenetic function of PDPN in MPM. Forty-seven of 52 tumors (90%) from Japanese patients with MPM and 3/6 (50%) MPM cell lines tested positive for PDPN. Knocking down PDPN in PDPN-high expressing MPM cells resulted in decreased cell motility. In contrast, overexpression of PDPN in PDPN-low expressing MPM cells enhanced cell motility. PDPN stimulated motility was mediated by activation of the RhoA/ROCK pathway. Moreover, knocking down PDPN with short hairpin (sh) RNA in PDPN-high expressing MPM cells resulted in decreased development of a thoracic tumor in mice with severe combined immune deficiency (SCID). In sharp contrast, transfection of PDPN in PDPN-low expressing MPM cells resulted in an increase in the number of Ki-67-positive proliferating tumor cells and it promoted progression of a thoracic tumor in SCID mice. Interestingly, PDPN promoted focus formation in vitro, and a low level of E-cadherin expression and YAP1 activation was observed in PDPN-high MPM tumors. These findings indicate that PDPN is a diagnostic marker as well as a pathogenetic regulator that promotes MPM progression by increasing cell motility and inducing focus formation. Therefore, PDPN might be a pathogenetic determinant of MPM dissemination and aggressive growth and may thus be an ideal therapeutic target. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

  16. The skill development temporary location with focus professional on the formation of the primary master

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Rojas González

    2018-01-01

    Full Text Available The development of skills as part of the integral formation of the primary teacher is today one of the main challenges in initial formation. In particular, to promote the development of the temporal location skill, it becomes a learning problem at the same time as a professional problem, so that they can understand the past, to understand the present and project the future, with modes of action consistent with social demands. The objective of this paper is to present the results of the study carried out on the current state of this process of development of the temporary location skill with a professional focus in the career Degree in Primary Education, at the University of Pinar del Río. For this, methods such as the historical-logical, the documentary analysis, the interview with teachers, the survey of teachers in training and the observation of classes were used, which allowed to verify the current state of said process in the initial formation of the primary teacher, taking as a methodological basis the dialectical-materialist method. From the systematization carried out it was possible to know that the subject has been little addressed, in the particular context of this professional in the undergraduate. In the historical evolution of the various curricula, the appropriation of the internal structure of this skill on the part of the students has not yet been achieved, which significantly limits the pertinence of the training process, negatively affecting the fact that students appropriate historical content and develop historical reasoning.

  17. Cytosolic Hsp70/Hsc70 protein expression in lymphocytes exposed to low gamma-ray dose

    International Nuclear Information System (INIS)

    Manzanares A, E.; Vega C, H.R.; Letechipia de Leon, C.; Guzman E, L.J.; Garcia T, M.

    2004-01-01

    The purpose of this study was to evaluate the effect of low gamma ray intensity upon Hsp70 expression in human Iymphocytes. The heat shock proteins (Hsp) family, are a group of proteins present in all living organism, therefore there are highly conserved and are related to adaptation and evolution. At cellular level these proteins acts as chaperones correcting denatured proteins. When a stress agent, such heavy metals, UV, heat, etc. is affecting a cell a response to this aggression is triggered only through over expression of Hsp. Several studies has been carried out in which the cellular effect are observed, mostly of these studies uses large doses, but very few studies are related with low doses. Blood of healthy volunteers was obtained and the Iymphocytes were isolated by ficoll- histopaque gradient. Experimental lots were irradiated in a 137 Cs gamma-ray. Hsp70 expression was found since 0.5 c Gy, indicating a threshold to very low doses of gamma rays. (Author)

  18. Cytosolic Hsp70/Hsc70 protein expression in lymphocytes exposed to low gamma-ray dose

    Energy Technology Data Exchange (ETDEWEB)

    Manzanares A, E.; Vega C, H.R.; Letechipia de Leon, C. [Unidades Academicas de Estudios Nucleares, UAZ, A.P. 336, 98000 Zacatecas (Mexico)]. E-mail: emanz@cantera.reduaz.mx; Guzman E, L.J. [Unidad Academica de Biologia Experimental, Guadalupe, Zacatecas (Mexico); Garcia T, M. [LIBRA, Centro I and D, Campus Miguel Delibes, Valladolid 47011 (Spain)

    2004-07-01

    The purpose of this study was to evaluate the effect of low gamma ray intensity upon Hsp70 expression in human Iymphocytes. The heat shock proteins (Hsp) family, are a group of proteins present in all living organism, therefore there are highly conserved and are related to adaptation and evolution. At cellular level these proteins acts as chaperones correcting denatured proteins. When a stress agent, such heavy metals, UV, heat, etc. is affecting a cell a response to this aggression is triggered only through over expression of Hsp. Several studies has been carried out in which the cellular effect are observed, mostly of these studies uses large doses, but very few studies are related with low doses. Blood of healthy volunteers was obtained and the Iymphocytes were isolated by ficoll- histopaque gradient. Experimental lots were irradiated in a {sup 137} Cs gamma-ray. Hsp70 expression was found since 0.5 c Gy, indicating a threshold to very low doses of gamma rays. (Author)

  19. Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.

    Science.gov (United States)

    Someya, Masanori; Sakata, Koh-ichi; Matsumoto, Yoshihisa; Tauchi, Hiroshi; Kai, Masahiro; Hareyama, Masato; Fukushima, Masakazu

    2012-01-01

    Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase (DPYD), partially inhibits homologous recombination (HR) repair and has a radiosensitizing effect as well as enhanced sensitivity to Camptothecin (CPT). DPYD is the target protein for radiosensitization by Gimeracil. We investigated the mechanisms of sensitization of radiation and CPT by DPYD inhibition using DLD-1 cells treated with siRNA for DPYD. We investigated the focus formation of various kinds of proteins involved in HR and examined the phosphorylation of RPA by irradiation using Western blot analysis. DPYD depletion by siRNA significantly restrained the formation of radiation-induced foci of Rad51 and RPA, whereas it increased the number of foci of NBS1. The numbers of colocalization of NBS1 and RPA foci in DPYD-depleted cells after radiation were significantly smaller than in the control cells. These results suggest that DPYD depletion is attributable to decreased single-stranded DNA generated by the Mre11/Rad50/NBS1 complex-dependent resection of DNA double-strand break ends. The phosphorylation of RPA by irradiation was partially suppressed in DPYD-depleted cells, suggesting that DPYD depletion may partially inhibit DNA repair with HR by suppressing phosphorylation of RPA. DPYD depletion showed a radiosensitizing effect as well as enhanced sensitivity to CPT. The radiosensitizing effect of DPYD depletion plus CPT was the additive effect of DPYD depletion and CPT. DPYD depletion did not have a cell-killing effect, suggesting that DPYD depletion may not be so toxic. Considering these results, the combination of CPT and drugs that inhibit DPYD may prove useful for radiotherapy as a method of radiosensitization.

  20. Mechanisms of material removal and mass transport in focused ion beam nanopore formation

    Energy Technology Data Exchange (ETDEWEB)

    Das, Kallol, E-mail: das7@illinois.edu; Johnson, Harley T., E-mail: htj@illinois.edu [Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 West Green Street, MC-244, Urbana, Illinois 61801 (United States); Freund, Jonathan B., E-mail: jbfreund@illinois.edu [Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 West Green Street, MC-244, Urbana, Illinois 61801 (United States); Department of Aerospace Engineering, University of Illinois at Urbana-Champaign, 306 Talbot Laboratory, MC-236, 104 South Wright Street Urbana, Illinois 61801 (United States)

    2015-02-28

    Despite the widespread use of focused ion beam (FIB) processing as a material removal method for applications ranging from electron microscope sample preparation to nanopore processing for DNA sequencing, the basic material removal mechanisms of FIB processing are not well understood. We present the first complete atomistic simulation of high-flux FIB using large-scale parallel molecular dynamics (MD) simulations of nanopore fabrication in freestanding thin films. We focus on the root mechanisms of material removal and rearrangement and describe the role of explosive boiling in forming nanopores. FIB nanopore fabrication is typically understood to occur via sputter erosion. This can be shown to be the case in low flux systems, where individual ion impacts are sufficiently separated in time that they may be considered as independent events. But our detailed MD simulations show that in high flux FIB processing, above a threshold level at which thermal effects become significant, the primary mechanism of material removal changes to a significantly accelerated, thermally dominated process. Under these conditions, the target is heated by the ion beam faster than heat is conducted away by the material, leading quickly to melting, and then continued heating to nearly the material critical temperature. This leads to explosive boiling of the target material with spontaneous bubble formation and coalescence. Mass is rapidly rearranged at the atomistic scale, and material removal occurs orders of magnitude faster than would occur by simple sputtering. While the phenomenology is demonstrated computationally in silicon, it can be expected to occur at lower beam fluxes in other cases where thermal conduction is suppressed due to material properties, geometry, or ambient thermal conditions.

  1. Paleoescatology in the sopas formation (Upper Pleistocene) form Uruguay, paleobilogic focus

    International Nuclear Information System (INIS)

    Verde, M.; Ubilla, M.; Soloviy, J.

    1998-01-01

    Continental tetrapod coprolites are reported for the first time for Uruguay, these remains come from the Sopas Formation (Upper Pleistocene). They are assigned to carnivore mammals based on morphology and inclusions of micrommmal remains besides of other attributes.(author)

  2. Bubble Formation in Yield Stress Fluids Using Flow-Focusing and T-Junction Devices.

    Science.gov (United States)

    Laborie, Benoit; Rouyer, Florence; Angelescu, Dan E; Lorenceau, Elise

    2015-05-22

    We study the production of bubbles inside yield stress fluids (YSFs) in axisymmetric T-junction and flow-focusing devices. Taking advantage of yield stress over capillary stress, we exhibit a robust break-up mechanism reminiscent of the geometrical operating regime in 2D flow-focusing devices for Newtonian fluids. We report that when the gas is pressure driven, the dynamics is unsteady due to hydrodynamic feedback and YSF deposition on the walls of the channels. However, the present study also identifies pathways for potential steady-state production of bubbly YSFs at large scale.

  3. Methane production from formate, acetate and H2/CO2; focusing on kinetics and microbial characterization

    DEFF Research Database (Denmark)

    Pan, Xiaofang; Angelidaki, Irini; Alvarado-Morales, Merlin

    2016-01-01

    For evaluating the methanogenesis from typical methanogenic precursors (formate, acetate and H-2/CO2), CH4 production kinetics were investigated at 37 +/- 1 degrees C in batch anaerobic digestion tests and stimulated by modified Gompertz model. The results showed that maximum methanation rate from...... formate, acetate and H-2/CO2 were 19.58 +/- 0.49, 42.65 +/- 1.17 and 314.64 +/- 3.58 N mL/gVS/d in digested manure system and 6.53 +/- 0.31, 132.04 +/- 3.96 and 640.16 +/- 19.92 N mL/gVS/d in sewage sludge system during second generation incubation. Meanwhile the model could not fit well in granular...... sludge system, while the rate of formate methanation was faster than from H-2/CO2 and acetate. Considering both the kinetic results and microbial assay we could conclude that H-2/CO2 methanation was the fastest methanogenic step in digested manure and sewage sludge system with Methanomicrobiales...

  4. Formative Observation of Teaching: Focusing Peer Assistance on Teachers' Developmental Goals

    Science.gov (United States)

    Drew, Steve; Phelan, Liam; Lindsay, Katherine; Carbone, Angela; Ross, Bella; Wood, Kayleen; Stoney, Susan; Cottman, Caroline

    2017-01-01

    Peer observation of teaching can provide valuable insights into effective educational practices. By adopting a developmental focus, peer observation can also provide insights into how practices might be enhanced and, importantly, how enhancements in practices might be aligned to teachers' development goals. However, a review of peer observation of…

  5. Efficacy of formative evaluation using a focus group for a large classroom setting in an accelerated pharmacy program.

    Science.gov (United States)

    Nolette, Shaun; Nguyen, Alyssa; Kogan, David; Oswald, Catherine; Whittaker, Alana; Chakraborty, Arup

    2017-07-01

    Formative evaluation is a process utilized to improve communication between students and faculty. This evaluation method allows the ability to address pertinent issues in a timely manner; however, implementation of formative evaluation can be a challenge, especially in a large classroom setting. Using mediated formative evaluation, the purpose of this study is to determine if a student based focus group is a viable option to improve efficacy of communication between an instructor and students as well as time management in a large classroom setting. Out of 140 total students, six students were selected to form a focus group - one from each of six total sections of the classroom. Each focus group representative was responsible for collecting all the questions from students of their corresponding sections and submitting them to the instructor two to three times a day. Responses from the instructor were either passed back to pertinent students by the focus group representatives or addressed directly with students by the instructor. This study was conducted using a fifteen-question survey after the focus group model was utilized for one month. A printed copy of the survey was distributed in the class by student investigators. Questions were of varying types, including Likert scale, yes/no, and open-ended response. One hundred forty surveys were administered, and 90 complete responses were collected. Surveys showed that 93.3% of students found that use of the focus group made them more likely to ask questions for understanding. The surveys also showed 95.5% of students found utilizing the focus group for questions allowed for better understanding of difficult concepts. General open-ended answer portions of the survey showed that most students found the focus group allowed them to ask questions more easily since they did not feel intimidated by asking in front of the whole class. No correlation was found between demographic characteristics and survey responses. This may

  6. Beam halo formation from space-charge dominated beams in uniform focusing channels

    International Nuclear Information System (INIS)

    O'Connell, J.S.; Wangler, T.P.; Mills, R.S.; Crandall, K.R.

    1993-01-01

    In space-charge dominated beams the nonlinear space-charge forces produce a filamentation pattern, which results in a 2-component beam consisting of an inner core and an outer halo. The halo is very prominent in mismatched beams, and the potential for accelerator activation is of concern for a next generation of cw, high-power proton linacs that could be applied for intense neutron generators to process nuclear materials. We present new results about beam halo and the evolution of space-charge dominated beams from multiparticle simulation of initial laminar beams in a uniform linear focusing channel, and from a model consisting of single particle interactions with a uniform-density beam core. We study the energy gain from particle interactions with the space-charge field of the core, and we identify the resonant characteristic of this interaction as the basic cause of the separation of the beam into the two components. We identify three different particle-trajectory types, and we suggest that one of these types may lead to continuous halo growth, even after the halo is removed by collimators

  7. Increased drop formation frequency via reduction of surfactant interactions in flow-focusing microfluidic devices.

    Science.gov (United States)

    Josephides, Dimitris N; Sajjadi, Shahriar

    2015-01-27

    Glass capillary based microfluidic devices are able to create extremely uniform droplets, when formed under the dripping regime, at low setup costs due to their ease of manufacture. However, as they are rarely parallelized, simple methods to increase droplet production from a single device are sought. Surfactants used to stabilize drops in such systems often limit the maximum flow rate that highly uniform drops can be produced due to the lowering interfacial tension causing jetting. In this paper we show that by simple design changes we can limit the interactions of surfactants and maximize uniform droplet production. Three flow-focused configurations are explored: a standard glass capillary device (consisting of a single round capillary inserted into a square capillary), a nozzle fed device, and a surfactant shielding device (both consisting of two round capillaries inserted into either end of a square capillary). In principle, the maximum productivity of uniform droplets is achieved if surfactants are not present. It was found that surfactants in the standard device greatly inhibit droplet production by means of interfacial tension lowering and tip-streaming phenomena. In the nozzle fed configuration, surfactant interactions were greatly limited, yielding flow rates comparable to, but lower than, a surfactant-free system. In the surfactant shielding configuration, flow rates were equal to that of a surfactant-free system and could make uniform droplets at rates an order of magnitude above the standard surfactant system.

  8. Variations of bubble cavitation and temperature elevation during lesion formation by high-intensity focused ultrasound.

    Science.gov (United States)

    Zhou, Yufeng; Gao, Xiaobin Wilson

    2013-08-01

    High-intensity focused ultrasound (HIFU) is emerging as an effective therapeutic modality in both thermal ablations for solid tumor/cancer and soft-tissue fragmentation. Mechanical and thermal effects, which play an important role in the HIFU treatment simultaneously, are dependent on the operating parameters and may vary with the progress of therapy. Mechanical erosion in the shape of a "squid," a "dumbbell" lesion with both mechanical and thermal lesions, or a "tadpole" lesion with mechanical erosion at the center and thermal necrosis on the boundary in the transparent gel phantom could be produced correspondingly with the pulse duration of 5-30 ms, which is much longer than histotripsy burst but shorter than the time for tissue boiling, and pulse repetition frequency (PRF) of 0.2-5 Hz. Meanwhile, variations of bubble cavitation (both inertial and stable cavitation) and temperature elevation in the focal region (i.e., z = -2.5, 0, and 2.5 mm) were measured by passive cavitation detection (PCD) and thermocouples during the therapeutic procedure, respectively. Stable cavitation increased with the pulse duration, PRF, and the number of pulses delivered. However, inertial cavitation was found to increase initially and then decrease with long pulse duration and high PRF. Temperature in the pre-focal region is always higher than those at the focal and post-focal position in all tests. Great variations of PCD signals and temperature elevation are due to the generation and persistence of large bubble, which is resistant to collapse and occurs with the increase of pulse duration and PRF. Similar lesion pattern and variations were also observed in ex vivo porcine kidneys. Hyperechoes in the B-mode ultrasound image were comparable to the shape and size of lesions in the dissected tissue. Thermal lesion volume increased with the increase of pulse duration and PRF, but mechanical erosion reached its maximum volume with the pulse duration of 20 ms and PRF of 1

  9. COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro

    Directory of Open Access Journals (Sweden)

    Petasis Nicos A

    2008-05-01

    Full Text Available Abstract Background An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex® is mediated primarily via the inhibition of COX-2. We have investigated this issue by applying two different analogs of celecoxib that differentially display COX-2-inhibitory activity: the first analog, called unmethylated celecoxib (UMC, inhibits COX-2 slightly more potently than its parental compound, whereas the second analog, 2,5-dimethyl-celecoxib (DMC, has lost the ability to inhibit COX-2. Results With the use of glioblastoma and pancreatic carcinoma cell lines, we comparatively analyzed the effects of celecoxib, UMC, and DMC in various short-term (≤48 hours cellular and molecular studies, as well as in long-term (≤3 months focus formation assays. We found that DMC exhibited the most potent antitumor activity; celecoxib was somewhat less effective, and UMC clearly displayed the overall weakest antitumor potential in all aspects. The differential growth-inhibitory and apoptosis-stimulatory potency of these compounds in short-term assays did not at all correlate with their capacity to inhibit COX-2, but was closely aligned with their ability to trigger endoplasmic reticulum stress (ERS, as indicated by the induction of the ERS marker CHOP/GADD153 and activation of the ERS-associated caspase 7. In addition, we found that these compounds were able to restore contact inhibition and block focus formation during long-term, chronic drug exposure of tumor cells, and this was achieved at sub-toxic concentrations in the absence of ERS or inhibition of COX-2. Conclusion The antitumor activity of celecoxib in vitro did not involve the inhibition of COX-2. Rather, the drug's ability to trigger ERS, a known effector of cell death, might provide an alternative explanation for its acute cytotoxicity. In addition, the newly discovered ability of this drug to restore contact inhibition and

  10. Volumetric intensity dependence on the formation of molecular and atomic ions within a high intensity laser focus.

    Science.gov (United States)

    Robson, Lynne; Ledingham, Kenneth W D; McKenna, Paul; McCanny, Thomas; Shimizu, Seiji; Yang, Jiamin M; Wahlström, Claes-Göran; Lopez-Martens, Rodrigo; Varju, Katalin; Johnsson, Per; Mauritsson, Johan

    2005-01-01

    The mechanism of atomic and molecular ionization in intense, ultra-short laser fields is a subject which continues to receive considerable attention. An inherent difficulty with techniques involving the tight focus of a laser beam is the continuous distribution of intensities contained within the focus, which can vary over several orders of magnitude. The present study adopts time of flight mass spectrometry coupled with a high intensity (8 x 10(15) Wcm(-2)), ultra-short (20 fs) pulse laser in order to investigate the ionization and dissociation of the aromatic molecule benzene-d1 (C(6)H(5)D) as a function of intensity within a focused laser beam, by scanning the laser focus in the direction of propagation, while detecting ions produced only in a "thin" slice (400 and 800 microm) of the focus. The resultant TOF mass spectra varies significantly, highlighting the dependence on the range of specific intensities accessed and their volumetric weightings on the ionization/dissociation pathways accessed.

  11. A preliminary study to detect CT radiation doses by using the γH2AX focus formation assay

    International Nuclear Information System (INIS)

    Zhang Bo; Gong Jianping; Zhang Wei; Yu Zeyang; Zhou Liying; Zhang Hong; Fu Jinxiang

    2010-01-01

    To prospectively determine if γH2AX (phosphorylated form of H2AX histone variant)-based visualization and quantification of DNA damage induced in peripheral blood mononuclear cells (PBMCs) can be used to estimate the radiation dose received after multi-detector computed tomography (CT) by the in vitro study, comprehend the correlation between the dose and the induced γH2AX foci, and explore its prospect. The result showed that, DNA damage first presented as γH2AX foci after CT, which can be detected by fluorescence microscope. The γH2AX focus yields linearly depend on the radiation dose after CT. γH2AX focus yield in blood cells may be a useful quantitative biomarker of human radiation exposure by CT scans. (authors)

  12. Effect of inserted metal at anode tip on formation of pulsed X-ray emitting zone of plasma focus device

    Science.gov (United States)

    Miremad, Seyed Milad; Shirani Bidabadi, Babak

    2018-04-01

    The effect of the anode's insert material of a plasma focus device on the properties of X-ray emission zone was studied. Inserts were fabricated out of six different materials including aluminum, copper, zinc, tin, tungsten, and lead to cover a wide range of atomic numbers. For each anode's insert material at different gas pressures and different voltages, the shape of X-ray emission zone was recorded by three pinhole cameras, which were installed on sidewall and roof of the chamber of plasma focus device. The results indicated that by changing the gas pressure and the charge voltage of capacitor, the X-ray source of plasma focus emerges with different forms as a concentrated column or conical shape with sharp or cloudy edges. These structures are in the form of a combination of plasma emission and anode-tip emission with different intensities. These observations indicate that the material of the anode-tip especially affects the structure of X-ray emission zone.

  13. Views of parents, teachers and children on health promotion in kindergarten--first results from formative focus groups and observations.

    Science.gov (United States)

    Sansolios, Sanne; Mikkelsen, Bent Egberg

    2011-10-01

    The aim of the study was to capture the views of children, parents and teachers on the topic of physical activity in kindergarten through observation and focus group interviews. The study was conducted in the kindergartens from the sampling group in the Danish part of PERISCOPE. 1(st) methodology: Children interviewed inside by the researcher on preferable movements and settings and then observed outside during their playtime. 2(nd) methodology: Children asked to draw themselves playing their most preferred physical activity. Parents and kindergarten teachers interviewed in two different groups, using an identical guide. Children are skilled in taking advantage of the space and facilities available for physical activity; girls need more support than boys to initiate physical activity; children are happy with the facilities and the toys available in the kindergarten. Teachers feel an increasing pressure to take more responsibility and initiatives for the children's health habits. Parents state that if more physical activity is initiated in the kindergarten, it could make children request domestic activity. Physical activity and movement concept are too abstract for children of this age to talk about: they quickly lose their focus and concentration. The new methodology of videotaping gives the researcher the chance to interpret facial expressions to capture movement, talk and actions, and to make a distinction among children, as they tend to interrupt each other. However, this method contains a weakness, if used alone, by the fact that the shooting is only a reflection of what the video camera has recorded.

  14. Exposure of zebra mussels to extracorporeal shock waves demonstrates formation of new mineralized tissue inside and outside the focus zone.

    Science.gov (United States)

    Sternecker, Katharina; Geist, Juergen; Beggel, Sebastian; Dietz-Laursonn, Kristin; de la Fuente, Matias; Frank, Hans-Georg; Furia, John P; Milz, Stefan; Schmitz, Christoph

    2018-04-03

    The success rate of extracorporeal shock wave therapy (ESWT) for fracture nonunions in human medicine (i.e., radiographic union at six months after ESWT) is only approximately 75%. Detailed knowledge regarding the underlying mechanisms that induce bio-calcification after ESWT is limited. We analyzed the biological response within mineralized tissue of a new invertebrate model organism, the zebra mussel Dreissena polymorpha , after exposure with extracorporeal shock waves (ESWs). Mussels were exposed to ESWs with positive energy density of 0.4 mJ/mm 2 (A) or were sham exposed (B). Detection of newly calcified tissue was performed by exposing the mussels to fluorescent markers. Two weeks later, the A-mussels showed a higher mean fluorescence signal intensity within the shell zone than the B-mussels (pmussels was independent of the size and position of the focal point of the ESWs. These data demonstrate that induction of bio-calcification after ESWT may not be restricted to the region of direct energy transfer of ESWs into calcified tissue. The results of the present study are of relevance for better understanding of the molecular and cellular mechanisms that induce formation of new mineralized tissue after ESWT. © 2018. Published by The Company of Biologists Ltd.

  15. A formative evaluation of a coach-based technical assistance model for youth- and family-focused programming.

    Science.gov (United States)

    Olson, Jonathan R; McCarthy, Kimberly J; Perkins, Daniel F; Borden, Lynne M

    2018-04-01

    The Children, Youth, and Families At-Risk (CYFAR) initiative provides funding and technical support for local community-based programs designed to promote positive outcomes among vulnerable populations. In 2013, CYFAR implemented significant changes in the way it provides technical assistance (TA) to grantees. These changes included introducing a new TA model in which trained coaches provide proactive support that is tailored to individual CYFAR projects. The purpose of this paper is to describe the evolution of this TA model and present preliminary findings from a formative evaluation. CYFAR Principal Investigators (PIs) were invited to respond to online surveys in 2015 and 2016. The surveys were designed to assess PI attitudes towards the nature and quality of support that they receive from their coaches. CYFAR PIs reported that their coaches have incorporated a range of coaching skills and techniques into their work. PIs have generally positive attitudes towards their coaches, and these attitudes have become more positive over time. Results suggest that CYFAR PIs have been generally supportive of the new TA system. Factors that may have facilitated support include a strong emphasis on team-building and the provision of specific resources that support program design, implementation, and evaluation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Child and Family-Focused Cognitive-Behavioral Therapy for Pediatric Bipolar Disorder: Pilot Study of Group Treatment Format

    Science.gov (United States)

    West, Amy E.; Jacobs, Rachel H.; Westerholm, Robert; Lee, Adabel; Carbray, Julie; Heidenreich, Jodi; Pavuluri, Mani N.

    2009-01-01

    Introduction: This study is a preliminary report of a group adaptation of child- and family-focused cognitive behavior therapy (CFF-CBT) for pediatric bipolar disorder (PBD). Methods: CFF-CBT group treatment was provided to twenty six families who had children with a diagnosis of PBD ranging between six- and twelve-years-old. Results: Results indicated that CFF-CBT was feasible and acceptable to families. CFF-CBT resulted in significant improvement in manic, but not depressive, symptoms and in children’s psychosocial functioning post-treatment. In addition, although not statistically significant, parents reported an increased ability to cope with their child’s illness. Results of this study suggest that group psychosocial treatment provided alongside pharmacotherapy may help attain remission of symptoms, as well as increase overall psychosocial coping and well-being in both children and parents. Conclusion: Future work must include a more rigorous test of CFF-CBT in a randomized controlled trial. PMID:19718425

  17. Upgrade with a sociocultural focus of the process of teaching-learning of the nuclear physics for the formation and professors' excellence

    International Nuclear Information System (INIS)

    Vazquez Conde, Julio P.

    2003-01-01

    When modernizing the teaching-learning procces of the nuclear physics, to put it in better correspondence with the current sociocultural context and to overcome the limitations presented in the professors formation, It have kept in mind a nucleus of ideas in those that it is synthesized the theoretical and practice experience in the field of the science didactics during the last decades. The idea defend in the investigation is that in correspondence with a sociocultural focus the process teaching-learning of the nuclear physics for the formation and professors should be structured around the most general problems that face the science, the technology and the society. The theoretical contribution of the work resides in the establishment of essential relationships among the teaching-learning of the nuclear physics, the sociocultural focus of the scientific education, the distinctive characteristics of the human psychic activity and of the activity scientist contemporary investigator, The practical contribution of the carried out work resides in the following results. a) strategy for the bring up to date of the process of teaching-learning of the nuclear physics, b) it programs of the subject the nuclear physics in the science, the technology and the society, c) systems of educational tasks, d) it structures basic of a place Web Science and nuclear Technology'', d) it programs computer of simulation of the dispersion of nuclear particles and and) I study on-line Nuclear Physics and the situation of the world'' (Author)

  18. Focus formation and neoplastic transformation by herpes simplex virus type 2 inactivated intracellularly by 5-bromo-2'-deoxyuridine and near UV light

    International Nuclear Information System (INIS)

    Manak, M.M.; Aurelian, L.; Ts'o, P.O.

    1981-01-01

    The induction of focus formation in low serum and of neoplastic transformation of Syrian hamster embryo cells was examined after the expression of herpes simplex virus type 2 functions. Syrian hamster embryo cells infected at a high multiplicity (5 PFU/cell) with 5-bromo-2'-deoxyuridine-labeled herpes simplex virus type 2 (11% substitution of thymidine residues) were exposed to near UV light irradiation at various times postinfection. This procedure specifically inactivated the viral genome, while having little, if any, effect on the unlabeled cellular DNA. Focus formation in 1% serum and neoplastic transformation were observed in cells exposed to virus inactivated before infection, but the frequency was enhanced (15- to 27-fold) in cells in which the virus was inactivated at 4 to 8 h postinfection. Only 2 to 45 independently isolated foci were capable of establishing tumorigenic lines. The established lines exhibited phenotypic alterations characteristic of a transformed state, including reduced serum requirement, anchorage-independent growth, and tumorigenicity. They retained viral DNA sequences and, even at relatively late passage, expressed viral antigens, including ICP 10

  19. PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage.

    Science.gov (United States)

    Tsanov, Nikolay; Kermi, Chames; Coulombe, Philippe; Van der Laan, Siem; Hodroj, Dana; Maiorano, Domenico

    2014-04-01

    Proliferating cell nuclear antigen (PCNA) is a well-known scaffold for many DNA replication and repair proteins, but how the switch between partners is regulated is currently unclear. Interaction with PCNA occurs via a domain known as a PCNA-Interacting Protein motif (PIP box). More recently, an additional specialized PIP box has been described, the « PIP degron », that targets PCNA-interacting proteins for proteasomal degradation via the E3 ubiquitin ligase CRL4(Cdt2). Here we provide evidence that CRL4(Cdt2)-dependent degradation of PIP degron proteins plays a role in the switch of PCNA partners during the DNA damage response by facilitating accumulation of translesion synthesis DNA polymerases into nuclear foci. We show that expression of a nondegradable PIP degron (Cdt1) impairs both Pol η and Pol κ focus formation on ultraviolet irradiation and reduces cell viability, while canonical PIP box-containing proteins have no effect. Furthermore, we identify PIP degron-containing peptides from several substrates of CRL4(Cdt2) as efficient inhibitors of Pol η foci formation. By site-directed mutagenesis we show that inhibition depends on a conserved threonine residue that confers high affinity for PCNA-binding. Altogether these findings reveal an important regulative role for the CRL4(Cdt2) pathway in the switch of PCNA partners on DNA damage.

  20. Development of a Web-Based Intervention for Addressing Distress in Caregivers of Patients Receiving Stem Cell Transplants: Formative Evaluation With Qualitative Interviews and Focus Groups

    Science.gov (United States)

    Pensak, Nicole Amoyal; Joshi, Tanisha; Simoneau, Teresa; Kilbourn, Kristin; Carr, Alaina; Kutner, Jean; Laudenslager, Mark L

    2017-06-22

    Caregivers of cancer patients experience significant burden and distress including depression and anxiety. We previously demonstrated the efficacy of an eight session, in-person, one-on-one stress management intervention to reduce distress in caregivers of patients receiving allogeneic hematopoietic stem cell transplants (allo-HSCT). The objective of this study was to adapt and enhance the in-person caregiver stress management intervention to a mobilized website (eg, tablet, smartphone, or computer-based) for self-delivery in order to enhance dissemination to caregiver populations most in need. We used an established approach for development of a mhealth intervention, completing the first two research and evaluation steps: Step One: Formative Research (eg, expert and stakeholder review from patients, caregivers, and palliative care experts) and Step Two: Pretesting (eg, Focus Groups and Individual Interviews with caregivers of patients with autologous HSCT (auto-HSCT). Step one included feedback elicited for a mock-up version of Pep-Pal session one from caregiver, patients and clinician stakeholders from a multidisciplinary palliative care team (N=9 caregivers and patient stakeholders and N=20 palliative care experts). Step two included two focus groups (N=6 caregivers) and individual interviews (N=9 caregivers) regarding Pep-Pal's look and feel, content, acceptability, and potential usability/feasibility. Focus groups and individual interviews were audio-recorded. In addition, individual interviews were transcribed, and applied thematic analysis was conducted in order to gain an in-depth understanding to inform the development and refinement of the mobilized caregiver stress management intervention, Pep-Pal (PsychoEducation and skills for Patient caregivers). Overall, results were favorable. Pep-Pal was deemed acceptable for caregivers of patients receiving an auto-HSCT. The refined Pep-Pal program consisted of 9 sessions (Introduction to Stress, Stress and the

  1. Focus on focusing

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    The discovery and impact of the principle of strong focusing was celebrated at a history Symposium at Stanford on 25 July in the course of the 1985 US Summer School on Particle Accelerators. Burt Richter, Stanford Linac Director, who introduced all the speakers with well chosen reminders about their various contributions related to the theme of the symposium, remarked that it was an appropriate time to be lauding the great contributions of accelerator physicists following the Nobel Prize award to Simon van der Meer for outstanding achievements in accelerator physics

  2. Focus on focusing

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1985-10-15

    The discovery and impact of the principle of strong focusing was celebrated at a history Symposium at Stanford on 25 July in the course of the 1985 US Summer School on Particle Accelerators. Burt Richter, Stanford Linac Director, who introduced all the speakers with well chosen reminders about their various contributions related to the theme of the symposium, remarked that it was an appropriate time to be lauding the great contributions of accelerator physicists following the Nobel Prize award to Simon van der Meer for outstanding achievements in accelerator physics.

  3. Jet formation and shock wave emission during collapse of ultrasound-induced cavitation bubbles and their role in the therapeutic applications of high-intensity focused ultrasound.

    Science.gov (United States)

    Brujan, E A; Ikeda, T; Matsumoto, Y

    2005-10-21

    The dynamics of inertial cavitation bubbles produced by short pulses of high-intensity focused ultrasound near a rigid boundary are studied to get a better understanding of the role of jet formation and shock wave emission during bubble collapse in the therapeutic applications of ultrasound. The bubble dynamics are investigated by high-speed photography with up to 2 million frames/s and acoustic measurements, as well as by numerical calculations. The significant parameter of this study is the dimensionless stand-off, gamma, which is defined as the distance of the bubble centre at its maximum expansion scaled by the maximum bubble radius. High-speed photography is applied to observe the bubble motion and the velocity of the liquid jet formed during bubble collapse. Hydrophone measurements are used to determine the pressure and the duration of the shock wave emitted during bubble rebound. Calculations yield the variation with time of the bubble wall, the maximum velocity and the kinetic energy of the re-entrant jet. The comparisons between experimental and numerical data are favourable with regard to both shape history and translational motion of the bubble. The acoustic energy constitutes the largest individual amount in the energy balance of bubble collapse. The ratio of the shock wave energy, measured at 10 mm from the emission centre, to the cavitation bubble energy was 1:2.4 at gamma = 1.55 and 1:3.5 at gamma = 1. At this distance, the shock wave pressure ranges from 0.122 MPa, at gamma = 1, to 0.162 MPa, at gamma = 1.55, and the temporal duration at the half maximum level is 87 ns. The maximum jet velocity ranges from 27 m s(-1), at gamma = 1, to 36 m s(-1), at gamma = 1.55. For gamma < 1.2, the re-entrant jet can generate an impact pressure on the nearby boundary larger than 50 MPa. We discuss the implications of the results for the therapeutic applications of high-intensity focused ultrasound.

  4. Jet formation and shock wave emission during collapse of ultrasound-induced cavitation bubbles and their role in the therapeutic applications of high-intensity focused ultrasound

    International Nuclear Information System (INIS)

    Brujan, E A; Ikeda, T; Matsumoto, Y

    2005-01-01

    The dynamics of inertial cavitation bubbles produced by short pulses of high-intensity focused ultrasound near a rigid boundary are studied to get a better understanding of the role of jet formation and shock wave emission during bubble collapse in the therapeutic applications of ultrasound. The bubble dynamics are investigated by high-speed photography with up to 2 million frames/s and acoustic measurements, as well as by numerical calculations. The significant parameter of this study is the dimensionless stand-off, γ, which is defined as the distance of the bubble centre at its maximum expansion scaled by the maximum bubble radius. High-speed photography is applied to observe the bubble motion and the velocity of the liquid jet formed during bubble collapse. Hydrophone measurements are used to determine the pressure and the duration of the shock wave emitted during bubble rebound. Calculations yield the variation with time of the bubble wall, the maximum velocity and the kinetic energy of the re-entrant jet. The comparisons between experimental and numerical data are favourable with regard to both shape history and translational motion of the bubble. The acoustic energy constitutes the largest individual amount in the energy balance of bubble collapse. The ratio of the shock wave energy, measured at 10 mm from the emission centre, to the cavitation bubble energy was 1:2.4 at γ = 1.55 and 1:3.5 at γ = 1. At this distance, the shock wave pressure ranges from 0.122 MPa, at γ = 1, to 0.162 MPa, at γ 1.55, and the temporal duration at the half maximum level is 87 ns. The maximum jet velocity ranges from 27 m s -1 , at γ = 1, to 36 m s -1 , at γ = 1.55. For γ < 1.2, the re-entrant jet can generate an impact pressure on the nearby boundary larger than 50 MPa. We discuss the implications of the results for the therapeutic applications of high-intensity focused ultrasound

  5. Formative Work to Develop a Tailored HIV Testing Smartphone App for Diverse, At-Risk, HIV-Negative Men Who Have Sex With Men: A Focus Group Study.

    Science.gov (United States)

    Mitchell, Jason W; Torres, Maria Beatriz; Joe, Jennifer; Danh, Thu; Gass, Bobbi; Horvath, Keith J

    2016-11-16

    Although gay, bisexual, and other men who have sex with men (MSM) are disproportionately affected by human immunodeficiency virus (HIV) infection, few test for HIV at regular intervals. Smartphone apps may be an ideal tool to increase regular testing among MSM. However, the success of apps to encourage regular testing among MSM will depend on how frequently the apps are downloaded, whether they continue to be used over months or years, and the degree to which such apps are tailored to the needs of this population. The primary objectives of this study were to answer the following questions. (1) What features and functions of smartphone apps do MSM believe are associated with downloading apps to their mobile phones? (2) What features and functions of smartphone apps are most likely to influence MSM's sustained use of apps over time? (3) What features and functions do MSM prefer in an HIV testing smartphone app? We conducted focus groups (n=7, with a total of 34 participants) with a racially and ethnically diverse group of sexually active HIV-negative MSM (mean age 32 years; 11/34 men, 33%, tested for HIV ≥10 months ago) in the United States in Miami, Florida and Minneapolis, Minnesota. Focus groups were digitally recorded, transcribed verbatim, and deidentified for analysis. We used a constant comparison method (ie, grounded theory coding) to examine and reexamine the themes that emerged from the focus groups. Men reported cost, security, and efficiency as their primary reasons influencing whether they download an app. Usefulness and perceived necessity, as well as peer and posted reviews, affected whether they downloaded and used the app over time. Factors that influenced whether they keep and continue to use an app over time included reliability, ease of use, and frequency of updates. Poor performance and functionality and lack of use were the primary reasons why men would delete an app from their phone. Participants also shared their preferences for an app to

  6. Formation flying as an innovative air transportation system for long-haul commercial flight : A focus on operational feasibility and potential gain

    NARCIS (Netherlands)

    Herinckx, L.E.; Gutleb, T.L.M.; Van Nunen, R.; Van Rompuy, E.; Bos, D.A.; Dijkers, H.P.A.; De Wit, J.; Radfar, H.; Sahin, S.E.; Beelarts van Blokland, W.W.A.

    2011-01-01

    Formation flying is introduced as a new and innovative air transportation system for long-haul commercial flight. With this paper the operational feasibility of formation flying is addressed, both from a market demand and economic, as well as an air traffic control perspective. Preliminary results

  7. Antimicrobial properties of Kalanchoe blossfeldiana: a focus on drug resistance with particular reference to quorum sensing-mediated bacterial biofilm formation.

    Science.gov (United States)

    Sarkar, Ratul; Mondal, Chaitali; Bera, Rammohan; Chakraborty, Sumon; Barik, Rajib; Roy, Paramita; Kumar, Alekh; Yadav, Kirendra K; Choudhury, Jayanta; Chaudhary, Sushil K; Samanta, Samir K; Karmakar, Sanmoy; Das, Satadal; Mukherjee, Pulok K; Mukherjee, Joydeep; Sen, Tuhinadri

    2015-07-01

    This study attempts to investigate the antimicrobial properties of Kalanchoe blossfeldiana with a particular reference to quorum sensing (QS)-mediated biofilm formation. The methanol extract of K. blossfeldiana leaves (MEKB) was evaluated for antimicrobial properties including QS-controlled production of biofilm (including virulence factor, motility and lactone formation) in Pseudomonas aeruginosa. Methanol extract of K. blossfeldiana was also evaluated for anti-cytokine (tumour necrosis factor-alpha, interleukin-6 and interleukin-1 beta) properties in peripheral blood mononuclear cells (PBMC). Methanol extract of K. blossfeldiana exhibited antimicrobial effect on clinical isolates, as well as standard reference strains. Pseudomonas aeruginosa exposed to MEKB (subminimum inhibitory concentration (MIC)) displayed reduced biofilm formation, whereas supra-MIC produced destruction of preformed biofilms. Methanol extract of K. blossfeldiana reduced the secretion of virulence factors (protease and pyoverdin) along with generation of acyl homoserine lactone (AHL). Confocal laser scanning microscopy images indicate reduction of biofilm thickness. The extract also reduced cytokine formation in lipopolysaccharide-stimulated PBMC. Kalanchoe blossfeldiana was found to interfere with AHL production, which in turn may be responsible for downregulating QS-mediated production of biofilm and virulence. This first report on the antibiofilm and anticytokine properties of this plant may open up new vistas for future exploration of this plant for combating biofilm-related resistant infections. © 2015 Royal Pharmaceutical Society.

  8. A Comparison of national CCS strategies for Northwest Europe, with a focus on the potential of common CO2 storage at the Utsira formation

    DEFF Research Database (Denmark)

    Ramirez, Andrea; Hoefnagels, Ric; van den Broek, Machteld

    2011-01-01

    Mega structures for CO2 storage, such as the Utsira formation in the North Sea, could theoretically supply CO2 storage capacity for several countries for a period of several decades. Their use could increase the cost-effectiveness of CCS in a region while minimizing opposition from the public to CO...... region Pan European TIMES model (PET). In the models scenarios, assumptions and parameters that are not country dependent (e.g. costs related with CO2 capture technology development) have been harmonized. The results indicate that with stringent climate targets, CCS appears as a key mitigation option...... in the national portfolio of measures. Within the CCS portfolio, storage of CO2 in the Utsira formation can indeed be a cost effective option for North Europe and it represents a valuable CO2 storage option at the regional level. For instance, the United Kingdom will profit from the comparably short transport...

  9. Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: a numerical study

    Energy Technology Data Exchange (ETDEWEB)

    Pichardo, Samuel; Hynynen, Kullervo [Imaging Research-Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room C713, Toronto, ON M4N 3M5 (Canada)

    2007-08-21

    Atrial fibrillation (AF) is the most frequently sustained cardiac arrhythmia affecting humans. The electrical isolation by ablation of the pulmonary veins (PVs) in the left atrium (LA) of the heart has been proven as an effective cure of AF. The ablation consists mainly in the formation of a localized circumferential thermal coagulation of the cardiac tissue surrounding the PVs. In the present numerical study, the feasibility of producing the required circumferential lesion with an endoesophageal ultrasound probe is investigated. The probe operates at 1 MHz and consists of a 2D array with enough elements (114 x 20) to steer the acoustic field electronically in a volume comparable to the LA. Realistic anatomical conditions of the thorax were considered from the segmentation of histological images of the thorax. The cardiac muscle and the blood-filled cavities in the heart were identified and considered in the sound propagation and thermal models. The influence of different conditions of the thermal sinking in the LA chamber was also studied. The circumferential ablation of the PVs was achieved by the sum of individual lesions induced with the proposed device. Different scenarios of lesion formation were considered where ultrasound exposures (1, 2, 5 and 10 s) were combined with maximal peak temperatures (60, 70 and 80 {sup 0}C). The results of this numerical study allowed identifying the limits and best conditions for controlled lesion formation in the LA using the proposed device. A controlled situation for the lesion formation surrounding the PVs was obtained when the targets were located within a distance from the device in the range of 26 {+-} 7 mm. When combined with a maximal temperature of 70 {sup 0}C and an exposure time between 5 and 10 s, this distance ensured preservation of the esophageal structures, controlled lesion formation and delivery of an acoustic intensity at the transducer surface that is compatible with existing materials. With a peak

  10. The social formation and cultural identity of Southeast Asian frontier society: Focused on the concept of maritime Zomia as frontier in connection with the ocean and the inland

    Directory of Open Access Journals (Sweden)

    Hong Seok-Joon

    2016-06-01

    Full Text Available This paper examines the applicability of the Zomia concept for social scientific studies of the Malaysian region, with a focus on the Malaysian port cities, including Melaka. While for both empirical and socio-cultural reasons the term Zomia itself may not be entirely appropriate to the Malaysian Melaka region, the analytical implications that are based on James C. Scott’s usage of it, particularly the emphasis on the cultural dynamics of inter-ethnic, inter-national, and inter-religious relations of port areas, can be of great utility to those working in the Malaysian region. Zomia is a neologism gaining popularity with the publication of James C. Scott’s provocative book, The art of not being governed: an anarchist history of upland Southeast Asia. The term of Zomia is designed to indicate the people who has not been governed by the nation-state and national regime.

  11. Focusing ethnography

    DEFF Research Database (Denmark)

    Woermann, Niklas

    2018-01-01

    underpinnings of focusing ethnographic research by comparing different schools of thought and suggesting a practice theory-based approach. It argues that many research projects are focused but do not reflect on the process of focusing, describes how to identify focal settings or practices, and introduces......Building theory with ethnography and filmic research increasingly requires focussing on key practices or settings, instead of painting a broad panorama of a culture. But few authors discuss why and how to focus. This article provides a systematic discussion of the theoretical and methodological...

  12. Focused Ethnography

    Directory of Open Access Journals (Sweden)

    Hubert Knoblauch

    2005-09-01

    Full Text Available In this paper I focus on a distinctive kind of sociological ethnography which is particularly, though not exclusively, adopted in applied research. It has been proposed that this branch of ethno­graphy be referred to as focused ethnography. Focused ethnography shall be delineated within the context of other common conceptions of what may be called conventional ethnography. However, rather than being opposed to it, focused ethno­graphy is rather complementary to conventional ethnography, particularly in fields that are charac­teristic of socially and functionally differentiated contemporary society. The paper outlines the back­ground as well as the major methodological features of focused ethnography, such as short-term field visits, data intensity and time intensity, so as to provide a background for future studies in this area. URN: urn:nbn:de:0114-fqs0503440

  13. Understanding the crack formation of graphite particles in cycled commercial lithium-ion batteries by focused ion beam - scanning electron microscopy

    Science.gov (United States)

    Lin, Na; Jia, Zhe; Wang, Zhihui; Zhao, Hui; Ai, Guo; Song, Xiangyun; Bai, Ying; Battaglia, Vincent; Sun, Chengdong; Qiao, Juan; Wu, Kai; Liu, Gao

    2017-10-01

    The structure degradation of commercial Lithium-ion battery (LIB) graphite anodes with different cycling numbers and charge rates was investigated by focused ion beam (FIB) and scanning electron microscopy (SEM). The cross-section image of graphite anode by FIB milling shows that cracks, resulted in the volume expansion of graphite electrode during long-term cycling, were formed in parallel with the current collector. The crack occurs in the bulk of graphite particles near the lithium insertion surface, which might derive from the stress induced during lithiation and de-lithiation cycles. Subsequently, crack takes place along grain boundaries of the polycrystalline graphite, but only in the direction parallel with the current collector. Furthermore, fast charge graphite electrodes are more prone to form cracks since the tensile strength of graphite is more likely to be surpassed at higher charge rates. Therefore, for LIBs long-term or high charge rate applications, the tensile strength of graphite anode should be taken into account.

  14. Electrowetting of liquid polymer on petal-mimetic microbowl-array surfaces for formation of microlens array with varying focus on a single substrate

    Science.gov (United States)

    Li, Xiangmeng; Shao, Jinyou; Li, Xiangming; Tian, Hongmiao

    2015-03-01

    In this paper, microlens array with varying focal lengths were fabricated on a single microbowl-array textured substrate. The solid microbowl-arrayed NOA61 (kind of polyurethane-based polymer with UV curablity) surface was resulted from nanoimprinting by polydimethylsiloxane (PDMS) mold. The PDMS mold was replicated from an SU-8 master which was generated by electron beam lithography. Such microbowl-arrayed surfaces demonstrate petal-mimetic highly adhesive hydrophobic wetting properties, which can promote an irreversible electrowetting (EW) effect and a dereased contact angle of water droplets as well as other liquid droplets by applying direct current (DC) voltage. To fabricate a microlens array with varying focal-lengths, liquid NOA61 was supplied from a syringe on the solid NOA61 microtextured film and DC voltage was applied succesively. After removing the DC voltage, these liquid NOA61 microdrops deposited on the solid microtextured NOA61 surface on tin-indium-oxide coated substrate could be solidified via UV irradiation, thus leading to microlens array with uneven numerical apertures on a single substrate. Numerical simulation was also done to verify the EW effect. Finally, optical imaging characterization was performed to confirm the varied focus of the NOA61 microdrops.

  15. Dense Plasma Focus Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hui [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Li, Shengtai [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jungman, Gerard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hayes-Sterbenz, Anna Catherine [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-31

    The mechanisms for pinch formation in Dense Plasma Focus (DPF) devices, with the generation of high-energy ions beams and subsequent neutron production over a relatively short distance, are not fully understood. Here we report on high-fidelity 2D and 3D numerical magnetohydrodynamic (MHD) simulations using the LA-COMPASS code to study the pinch formation dynamics and its associated instabilities and neutron production.

  16. Focused ultrasound in ophthalmology

    Directory of Open Access Journals (Sweden)

    Silverman RH

    2016-09-01

    Full Text Available Ronald H Silverman1,2 1Department of Ophthalmology, Columbia University Medical Center, 2F.L. Lizzi Center for Biomedical Engineering, Riverside Research, New York, NY, USA Abstract: The use of focused ultrasound to obtain diagnostically significant information about the eye goes back to the 1950s. This review describes the historical and technological development of ophthalmic ultrasound and its clinical application and impact. Ultrasound, like light, can be focused, which is crucial for formation of high-resolution, diagnostically useful images. Focused, single-element, mechanically scanned transducers are most common in ophthalmology. Specially designed transducers have been used to generate focused, high-intensity ultrasound that through thermal effects has been used to treat glaucoma (via cilio-destruction, tumors, and other pathologies. Linear and annular transducer arrays offer synthetic focusing in which precise timing of the excitation of independently addressable array elements allows formation of a converging wavefront to create a focus at one or more programmable depths. Most recently, linear array-based plane-wave ultrasound, in which the array emits an unfocused wavefront and focusing is performed solely on received data, has been demonstrated for imaging ocular anatomy and blood flow. While the history of ophthalmic ultrasound extends back over half-a-century, new and powerful technologic advances continue to be made, offering the prospect of novel diagnostic capabilities. Keywords: ophthalmic ultrasound, ultrasound biomicroscopy (UBM, high-intensity focused ultrasound (HIFU, ultrafast imaging, Doppler imaging 

  17. Without 'Focus'

    Directory of Open Access Journals (Sweden)

    Aldo Sevi

    2010-12-01

    Full Text Available It is widely accepted that a notion of 'focus', more or less as conceived of in Jackendoff (1972, must be incorporated into our theory of grammar, as a means of accounting for certain observed correlations between prosodic facts and semantic/pragmatic facts. In this paper, we put forth the somewhat radical idea that the time has come to give up this customary view, and eliminate 'focus' from our theory of grammar. We argue that such a move is both economical and fruitful.Research over the years has revealed that the correlations between prosody, 'focus', and the alleged semantic/pragmatic effects of focus are much less clear and systematic than we may have initially hoped. First we argue that this state of affairs detracts significantly from the utility of our notion of 'focus', to the point of calling into question the very motivation for including it in the grammar. Then we look at some of the central data, and show how they might be analyzed without recourse to a notion of 'focus'. We concentrate on (i the effect of pitch accent placement on discourse congruence, and (ii the choice of 'associate' for the so-called 'focus sensitive' adverb only. We argue that our focus-free approach to the data improves empirical coverage, and begins to reveal patterns that have previously been obscured by preconceptions about 'focus'.ReferencesBeaver, D. & Clark, B. 2008. Sense and Sensitivity: How Focus Determines Meaning. Blackwell.Beaver, D., Clark, B., Flemming, E., Jaeger, T. F. & Wolters, M. 2007. ‘When semantics meets phonetics: Acoustical studies of second occurrence focus’. Language 83.2: 245–76.http://dx.doi.org/10.1353/lan.2007.0053Beckman, M. & Hirschberg, J. 1994. ‘The ToBI Annotation Conventions’. Ms.,http://www.cs.columbia.edu/~julia/files/conv.pdf.Bolinger, D. 1972. ‘Accent is predictable (if you are a mind-reader’. Language 48.3: 633–44.http://dx.doi.org/10.2307/412039Büring, D. 2006. ‘Focus projection and default

  18. The induction of stromule formation by a plant DNA-virus in epidermal leaf tissues suggests a novel intra- and intercellular macromolecular trafficking route

    Directory of Open Access Journals (Sweden)

    Björn eKrenz

    2012-12-01

    Full Text Available Stromules are dynamic thin protrusions of membrane envelope from plant cell plastids. Despite considerable progress in understanding the importance of certain cytoskeleton elements and motor proteins for stromule maintenance, their function within the cell has yet to be unraveled. Several viruses cause a remodulation of plastid structures and stromule biogenesis within their host plants. For RNA-viruses these interactions were demonstrated to be relevant to the infection process. An involvement of plastids and stromules is assumed in the DNA-virus life cycle as well, but their functional role needs to be determined. Recent findings support a participation of heat shock cognate 70 kDa protein (cpHSC70-1-containing stromules induced by a DNA-virus infection (Abutilon mosaic virus, AbMV, Geminiviridae in intra- and intercellular molecule exchange. The chaperone cpHSC70-1 was shown to interact with the AbMV movement protein (MP. Bimolecular fluorescence complementation confirmed the interaction of cpHSC70-1 and MP, and showed a homo-oligomerization of either protein in planta. The complexes were detected at the cellular margin and co-localized with plastids. In healthy plant tissues cpHSC70-1-oligomers occurred in distinct spots at chloroplasts and in small filaments extending from plastids to the cell periphery. AbMV-infection induced a cpHSC70-1-containing stromule network that exhibits elliptical dilations and transverses whole cells. Silencing of the cpHSC70-gene revealed an impact of cpHSC70 on chloroplast stability and restricted AbMV movement, but not viral DNA accumulation. Based on these data, a model is suggested in which these stromules function in molecule exchange between plastids and other organelles and perhaps other cells. AbMV may utilize cpHSC70-1 for trafficking along plastids and stromules into a neighboring cell or from plastids into the nucleus. Experimental approaches to investigate this hypothesis are discussed.

  19. Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine

    International Nuclear Information System (INIS)

    Kurashige, Tomomi; Shimamura, Mika; Nagayama, Yuji

    2016-01-01

    The biological effect of ionizing radiation (IR) on genomic DNA is thought to be either direct or indirect; the latter is mediated by IR induction of free radicals and reactive oxygen species (ROS). This study was designed to evaluate the effect of N-acetyl-L-cysteine (NAC), a well-known ROS-scavenging antioxidant, on IR induction of genotoxicity, cytotoxicity and ROS production in mammalian cells, and aimed to clarify the conflicting data in previous publications. Although we clearly demonstrate the beneficial effect of NAC on IR-induced genotoxicity and cytotoxicity (determined using the micronucleus assay and cell viability/clonogenic assays), the data on NAC's effect on DNA double-strand break (DSB) formation were inconsistent in different assays. Specifically, mitigation of IR-induced DSBs by NAC was readily detected by the neutral comet assay, but not by the γH2AX or 53BP1 focus assays. NAC is a glutathione precursor and exerts its effect after conversion to glutathione, and presumably it has its own biological activity. Assuming that the focus assay reflects the biological responses to DSBs (detection and repair), while the comet assay reflects the physical status of genomic DNA, our results indicate that the comet assay could readily detect the antioxidant effect of NAC on DSB formation. However, NAC's biological effect might affect the detection of DSB repair by the focus assays. Our data illustrate that multiple parameters should be carefully used to analyze DNA damage when studying potential candidates for radioprotective compounds

  20. Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine.

    Science.gov (United States)

    Kurashige, Tomomi; Shimamura, Mika; Nagayama, Yuji

    2016-06-01

    The biological effect of ionizing radiation (IR) on genomic DNA is thought to be either direct or indirect; the latter is mediated by IR induction of free radicals and reactive oxygen species (ROS). This study was designed to evaluate the effect of N-acetyl-L-cysteine (NAC), a well-known ROS-scavenging antioxidant, on IR induction of genotoxicity, cytotoxicity and ROS production in mammalian cells, and aimed to clarify the conflicting data in previous publications. Although we clearly demonstrate the beneficial effect of NAC on IR-induced genotoxicity and cytotoxicity (determined using the micronucleus assay and cell viability/clonogenic assays), the data on NAC's effect on DNA double-strand break (DSB) formation were inconsistent in different assays. Specifically, mitigation of IR-induced DSBs by NAC was readily detected by the neutral comet assay, but not by the γH2AX or 53BP1 focus assays. NAC is a glutathione precursor and exerts its effect after conversion to glutathione, and presumably it has its own biological activity. Assuming that the focus assay reflects the biological responses to DSBs (detection and repair), while the comet assay reflects the physical status of genomic DNA, our results indicate that the comet assay could readily detect the antioxidant effect of NAC on DSB formation. However, NAC's biological effect might affect the detection of DSB repair by the focus assays. Our data illustrate that multiple parameters should be carefully used to analyze DNA damage when studying potential candidates for radioprotective compounds. © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

  1. Material focus

    DEFF Research Database (Denmark)

    Sokoler, Tomas; Vallgårda, Anna K. A.

    2009-01-01

    In this paper we build on the notion of computational composites, which hold a material perspective on computational technology. We argue that a focus on the material aspects of the technology could be a fruitful approach to achieve new expressions and to gain a new view on the technology's role...... in design. We study two of the computer's material properties: computed causality and connectability and through developing two computational composites that utilize these properties we begin to explore their potential expressions....

  2. Plasma Focus

    International Nuclear Information System (INIS)

    Bernard, Alain; Jolas, Alain; Garconnet, J.-P.; Mascureau, J. de; Nazet, Christian; Coudeville, Alain; Bekiarian, Andre.

    1977-01-01

    The present report is the edition of the lectures given in a conference on the Focus experiment held at the Centre d'etudes de Limeil, on Oct. 1975. After a survey of the early laboratories one will find the main results obtained in Limeil concerning interferometry, laser scattering, electric and magnetic-measurements, X-ray and neutron emission and also the possible use of explosive current generators instead of capacitor banks at high energy levels. The principal lines of future research are given in the conclusion [fr

  3. Focus: Digital

    DEFF Research Database (Denmark)

    Technology has been an all-important and defining element within the arts throughout the 20th century, and it has fundamentally changed the ways in which we produce and consume music. With this Focus we investigate the latest developments in the digital domain – and their pervasiveness and rapid...... production and reception of contemporary music and sound art. With ‘Digital’ we present four composers' very different answers to how technology impact their work. To Juliana Hodkinson it has become an integral part of her sonic writing. Rudiger Meyer analyses the relationships between art and design and how...

  4. Focusing horn

    CERN Multimedia

    1980-01-01

    This was the first magnetic horn developed by Simon Van der Meer to collect antiprotons in the AD complex. It was used for the AA (antiproton accumulator). Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV/c (protons at 26GeV/c, antiprotons at 3.6GeV/c) in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet. For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 -, three hundred thousand million - antiprotons. The development of this technology was a key step to the functioning of CERN's Super Proton Synchrotron as a proton - antiproton collider.

  5. Star formation

    International Nuclear Information System (INIS)

    Woodward, P.R.

    1978-01-01

    Theoretical models of star formation are discussed beginning with the earliest stages and ending in the formation of rotating, self-gravitating disks or rings. First a model of the implosion of very diffuse gas clouds is presented which relies upon a shock at the edge of a galactic spiral arm to drive the implosion. Second, models are presented for the formation of a second generation of massive stars in such a cloud once a first generation has formed. These models rely on the ionizing radiation from massive stars or on the supernova shocks produced when these stars explode. Finally, calculations of the gravitational collapse of rotating clouds are discussed with special focus on the question of whether rotating disks or rings are the result of such a collapse. 65 references

  6. Focused detection logging technique

    International Nuclear Information System (INIS)

    Turcotte, R.E.

    1977-01-01

    In accordance with an illustrative embodiment of the present invention, a method and apparatus is disclosed for determining a characteristic of the media surrounding a borehole by emitting gamma radiation in at least one tightly collimated beam toward an earth formation adjacent a borehole, by detecting from a plurality of tightly collimated paths that are focused at a zone of intersection with and aligned to intersect with each emitted beam the gamma radiation scattered by the interaction of the emitted gamma radiation and the media at the zones of intersection, by misaligning the emitted beams and the tightly collimated paths to prevent their intersection, by detecting gamma radiation scattered by the interaction of the emitted gamma radiation and the media with the emitted beams and the tightly collimated paths misaligned and by determining from the detected gamma radiation a media characteristic. In one embodiment, the detection collimater used is formed of a material that is essentially opaque to gamma radiation at the energies of interest and includes a plurality of passageways that are spherically focused at a zone of intersection with one of the emitted beams of gamma radiation and that are arranged in a number of surfaces that are curved to be azimuthally symmetrical about the axis of the intersected beam. 14 figures

  7. Features of dynamics of sanitary losses formation in case of large-scale radiation accidents and organization of hospital functioning when admitting the injured persons from the radiation focus

    International Nuclear Information System (INIS)

    Avetisov, G.M.; Vorontsov, I.V.; Goncharov, S.F.; Ivanov, V.B.

    1995-01-01

    Specific features of therapeutic-evacuation and sanitary-hygienic arrangements in case of large-scale radiation accidents are considered. The substantiation is given for the necessity of setting up to a field hospital near the focus of such an accident for rendering first medical aid and expert medical care, distribution of the injured and organization of their evacuation to specialized medical establishments in due time. 17 refs.; 1 tab

  8. Characterization of Aes nuclear foci in colorectal cancer cells

    Science.gov (United States)

    Itatani, Yoshiro; Sonoshita, Masahiro; Kakizaki, Fumihiko; Okawa, Katsuya; Stifani, Stefano; Itoh, Hideaki; Sakai, Yoshiharu; Taketo, M. Mark

    2016-01-01

    Amino-terminal enhancer of split (Aes) is a member of Groucho/Transducin-like enhancer (TLE) family. Aes is a recently found metastasis suppressor of colorectal cancer (CRC) that inhibits Notch signalling, and forms nuclear foci together with TLE1. Although some Notch-associated proteins are known to form subnuclear bodies, little is known regarding the dynamics or functions of these structures. Here, we show that Aes nuclear foci in CRC observed under an electron microscope are in a rather amorphous structure, lacking surrounding membrane. Investigation of their behaviour during the cell cycle by time-lapse cinematography showed that Aes nuclear foci dissolve during mitosis and reassemble after completion of cytokinesis. We have also found that heat shock cognate 70 (HSC70) is an essential component of Aes foci. Pharmacological inhibition of the HSC70 ATPase activity with VER155008 reduces Aes focus formation. These results provide insight into the understanding of Aes-mediated inhibition of Notch signalling. PMID:26229111

  9. Needs of Non Energy-Focused Contractors

    Energy Technology Data Exchange (ETDEWEB)

    Liaukus, C.

    2012-12-01

    To better understand the informational needs of non energy-focused contractors, including what information they need to motivate them to become energy-focused, the BARA team studied the type of information provided by the national programs, trade associations, and manufacturers that were researched for the related technical report: Effective Communication of Energy Efficiency. While that report focused on the delivery method, format, and strategy of the information, this study examines the content being put forward.

  10. Needs of Non-Energy Focused Contractors

    Energy Technology Data Exchange (ETDEWEB)

    Liakus, C. [Building Media and the Building America Retrofit Alliance (BARA), Wilmington, DE (United States)

    2012-12-01

    To better understand the informational needs of non-energy focused contractors, including what information they need to motivate them to become energy-focused, the BARA team studied the type of information provided by the national programs, trade associations, and manufacturers that were researched for the related technical report: Effective Communication of Energy Efficiency. While that report focused on the delivery method, format, and strategy of the information, this study examines the content being put forward.

  11. Suppression of radiation excitation in focusing environment

    International Nuclear Information System (INIS)

    Huang, Z.; Ruth, R.D.

    1996-12-01

    Radiation damping and quantum excitation in an electron damping ring and a straight focusing channel are reviewed. They are found to be the two limiting cases in the study of a general bending and focusing combined system. In the intermediate regime where the radiation formation length is comparable to the betatron wavelength, quantum excitation can be exponentially suppressed by focusing field. This new regime may have interesting applications in the generation of ultra-low emittance beams

  12. Plasma focus breeder

    International Nuclear Information System (INIS)

    Ikuta, Kazunari.

    1981-09-01

    Instead of using linear accelerators, it is possible to breed fissile fuels with the help of high current plasma focus device. A mechanism of accelerating proton beam in plasma focus device to high energy would be a change of inductance in plasma column because of rapid growth of plasma instability. A possible scheme of plasma focus breeder is also proposed. (author)

  13. Formate Formation and Formate Conversion in Biological Fuels Production

    Directory of Open Access Journals (Sweden)

    Bryan R. Crable

    2011-01-01

    Full Text Available Biomethanation is a mature technology for fuel production. Fourth generation biofuels research will focus on sequestering CO2 and providing carbon-neutral or carbon-negative strategies to cope with dwindling fossil fuel supplies and environmental impact. Formate is an important intermediate in the methanogenic breakdown of complex organic material and serves as an important precursor for biological fuels production in the form of methane, hydrogen, and potentially methanol. Formate is produced by either CoA-dependent cleavage of pyruvate or enzymatic reduction of CO2 in an NADH- or ferredoxin-dependent manner. Formate is consumed through oxidation to CO2 and H2 or can be further reduced via the Wood-Ljungdahl pathway for carbon fixation or industrially for the production of methanol. Here, we review the enzymes involved in the interconversion of formate and discuss potential applications for biofuels production.

  14. Dense Plasma Focus Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hui [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Li, Shengtai [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jungman, Gerard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hayes-Sterbenz, Anna Catherine [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-07-10

    Here we report on high-fidelity 2D and 3D numerical magnetohydrodynamic (MHD) simulations using the LA-COMPASS code to study the pinch formation dynamics in a DPF and the associated instabilities and neutron production.

  15. Space Focus Lead Report

    Energy Technology Data Exchange (ETDEWEB)

    Reeves, Geoffrey D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-10

    The Space Focus team is tasked with the definition of the Space Focused Science Topics, and with the review and ranking of the CSES proposals received in all the program areas. This is achieved by dedicated meetings or a series of informal discussions and/or e-mail reviews.

  16. BrightFocus Foundation

    Science.gov (United States)

    ... About BrightFocus Foundation Featured Content BrightFocus: Investing in Science to Save Mind and Sight We're here to help. Explore ... recognition is very important. Monday, November 6, 2017 New Diagnosis? Managing a mind and sight disease is a journey. And you’ ...

  17. Stellar formation

    CERN Document Server

    Reddish, V C

    1978-01-01

    Stellar Formation brings together knowledge about the formation of stars. In seeking to determine the conditions necessary for star formation, this book examines questions such as how, where, and why stars form, and at what rate and with what properties. This text also considers whether the formation of a star is an accident or an integral part of the physical properties of matter. This book consists of 13 chapters divided into two sections and begins with an overview of theories that explain star formation as well as the state of knowledge of star formation in comparison to stellar structure

  18. Galaxy formation

    International Nuclear Information System (INIS)

    Silk, J.; Di Cintio, A.; Dvorkin, I.

    2014-01-01

    Galaxy formation is at the forefront of observation and theory in cosmology. An improved understanding is essential for improving our knowledge both of the cosmological parameters, of the contents of the universe, and of our origins. In these lectures intended for graduate students, galaxy formation theory is reviewed and confronted with recent observational issues. In lecture 1, the following topics are presented: star formation considerations, including IMF, star formation efficiency and star formation rate, the origin of the galaxy luminosity function, and feedback in dwarf galaxies. In lecture 2, we describe formation of disks and massive spheroids, including the growth of supermassive black holes, negative feedback in spheroids, the AGN-star formation connection, star formation rates at high redshift and the baryon fraction in galaxies.

  19. Optimization of sources for focusing wave energy in targeted formations

    KAUST Repository

    Jeong, C; Kallivokas, L F; Huh, C; Lake, L W

    2010-01-01

    that will maximize the kinetic energy in the target zone, while keeping silent the neighbouring zones. To this end, we cast the problem as an inverse-source problem, and use a partial-differential- equation-constrained optimization approach to arrive at an optimized

  20. Final focus nomenclature

    International Nuclear Information System (INIS)

    Erickson, R.

    1986-01-01

    The formal names and common names for all devices in the final focus system of the SLC are listed. The formal names consist of a device type designator, microprocessor designator, and a four-digit unit number

  1. Final focus test beam

    International Nuclear Information System (INIS)

    1991-03-01

    This report discusses the following: the Final Focus Test Beam Project; optical design; magnets; instrumentation; magnetic measurement and BPM calibration; mechanical alignment and stabilization; vacuum system; power supplies; control system; radiation shielding and personnel protection; infrastructure; and administration

  2. Facility Focus: Food Service.

    Science.gov (United States)

    College Planning & Management, 2002

    2002-01-01

    Describes the Hawthorn Court Community Center at Iowa State University, Ames, and the HUB-Robeson Center at Pennsylvania State University. Focuses on the food service offered in these new student-life buildings. Includes photographs. (EV)

  3. Focus group discussions

    CERN Document Server

    Hennink, Monique M

    2014-01-01

    The Understanding Research series focuses on the process of writing up social research. The series is broken down into three categories: Understanding Statistics, Understanding Measurement, and Understanding Qualitative Research. The books provide researchers with guides to understanding, writing, and evaluating social research. Each volume demonstrates how research should be represented, including how to write up the methodology as well as the research findings. Each volume also reviews how to appropriately evaluate published research. Focus Group Discussions addresses the challenges associated with conducting and writing focus group research. It provides detailed guidance on the practical and theoretical considerations in conducting focus group discussions including: designing the discussion guide, recruiting participants, training a field team, moderating techniques and ethical considerations. Monique Hennink describes how a methodology section is read and evaluated by others, such as journal reviewers or ...

  4. Final focus nomenclature

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, R.

    1986-08-08

    The formal names and common names for all devices in the final focus system of the SLC are listed. The formal names consist of a device type designator, microprocessor designator, and a four-digit unit number. (LEW)

  5. High harmonics focusing undulator

    Energy Technology Data Exchange (ETDEWEB)

    Varfolomeev, A.A.; Hairetdinov, A.H.; Smirnov, A.V.; Khlebnikov, A.S. [Kurchatov Institute, Moscow (Russian Federation)

    1995-12-31

    It was shown in our previous work that there exist a possibility to enhance significantly the {open_quote}natural{close_quote} focusing properties of the hybrid undulator. Here we analyze the actual undulator configurations which could provide such field structure. Numerical simulations using 2D code PANDIRA were carried out and the enhanced focusing properties of the undulator were demonstrated. The obtained results provide the solution for the beam transport in a very long (short wavelength) undulator schemes.

  6. The Individually Focused Interview

    DEFF Research Database (Denmark)

    Clausen, Aksel Skovgaard

    2012-01-01

    relatively “strong” interviewees (interview persons: IPs) with diverse backgrounds; (2) thorough planning of the interview with well-focused themes; and (3) a thorough and repeated introduction to the interview. The omission of audio transcriptions is an obvious solution to the researcher who wants a breadth...... of range of statements stemming from the use of many more interviewees than is often possible. The Individually Focused Interview (TIFI) also provides more time for involvement in the field and further analysis....

  7. Plutonium focus area

    International Nuclear Information System (INIS)

    1996-08-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this new approach, EM developed a management structure and principles that led to the creation of specific Focus Areas. These organizations were designed to focus the scientific and technical talent throughout DOE and the national scientific community on the major environmental restoration and waste management problems facing DOE. The Focus Area approach provides the framework for intersite cooperation and leveraging of resources on common problems. After the original establishment of five major Focus Areas within the Office of Technology Development (EM-50, now called the Office of Science and Technology), the Nuclear Materials Stabilization Task Group (EM-66) followed the structure already in place in EM-50 and chartered the Plutonium Focus Area (PFA). The following information outlines the scope and mission of the EM, EM-60, and EM-66 organizations as related to the PFA organizational structure

  8. Plasma focus matching conditions

    International Nuclear Information System (INIS)

    Soliman, H.M.; Masoud, M.M.; Elkhalafawy, T.A.

    1988-01-01

    A snow-plough and slug models have been used to obtain the optimum matching conditions of the plasma in the focus. The dimensions of the plasma focus device are, inner electrode radius = 2 cm, outer electrode radius = 5.5 cm, and its length = 8 cm. It was found that the maximum magnetic energy of 12.26 kJ has to be delivered to plasma focus whose density is 10 19 /cm 3 at focusing time of 2.55 μs and with total external inductance of 24.2 n H. The same method is used to evaluate the optimum matching conditions for the previous coaxial discharge system which had inner electrode radius = 1.6 cm, outer electrode radius = 3.3 cm and its length = 31.5 cm. These conditions are charging voltage = 12 kV, capacity of the condenser bank = 430 μf, plasma focus density = 10 19 /cm 3 focusing time = 8 μs and total external inductance = 60.32 n H.3 fig., 2 tab

  9. Virus-Induced Chaperone-Enriched (VICE domains function as nuclear protein quality control centers during HSV-1 infection.

    Directory of Open Access Journals (Sweden)

    Christine M Livingston

    2009-10-01

    Full Text Available Virus-Induced Chaperone-Enriched (VICE domains form adjacent to nuclear viral replication compartments (RC during the early stages of HSV-1 infection. Between 2 and 3 hours post infection at a MOI of 10, host protein quality control machinery such as molecular chaperones (e.g. Hsc70, the 20S proteasome and ubiquitin are reorganized from a diffuse nuclear distribution pattern to sequestration in VICE domains. The observation that VICE domains contain putative misfolded proteins suggests that they may be similar to nuclear inclusion bodies that form under conditions in which the protein quality control machinery is overwhelmed by the presence of misfolded proteins. The detection of Hsc70 in VICE domains, but not in nuclear inclusion bodies, indicates that Hsc70 is specifically reorganized by HSV-1 infection. We hypothesize that HSV-1 infection induces the formation of nuclear protein quality control centers to remodel or degrade aberrant nuclear proteins that would otherwise interfere with productive infection. Detection of proteolytic activity in VICE domains suggests that substrates may be degraded by the 20S proteasome in VICE domains. FRAP analysis reveals that GFP-Hsc70 is dynamically associated with VICE domains, suggesting a role for Hsc70 in scanning the infected nucleus for misfolded proteins. During 42 degrees C heat shock, Hsc70 is redistributed from VICE domains into RC perhaps to remodel viral replication and regulatory proteins that have become insoluble in these compartments. The experiments presented in this paper suggest that VICE domains are nuclear protein quality control centers that are modified by HSV-1 to promote productive infection.

  10. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...... effectively measures the intended phenomenon (i.e., journal specialisation). Only weak correlations were found between journal re-citations and obsolescence, journal self-citations, and number of references. Conclusions. The focus factor successfully measures journal specialisation over time. Measures based...

  11. Decontamination & decommissioning focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    In January 1994, the US Department of Energy Office of Environmental Management (DOE EM) formally introduced its new approach to managing DOE`s environmental research and technology development activities. The goal of the new approach is to conduct research and development in critical areas of interest to DOE, utilizing the best talent in the Department and in the national science community. To facilitate this solutions-oriented approach, the Office of Science and Technology (EM-50, formerly the Office of Technology Development) formed five Focus AReas to stimulate the required basic research, development, and demonstration efforts to seek new, innovative cleanup methods. In February 1995, EM-50 selected the DOE Morgantown Energy Technology Center (METC) to lead implementation of one of these Focus Areas: the Decontamination and Decommissioning (D & D) Focus Area.

  12. Reconsidering Formative Measurement

    Science.gov (United States)

    Howell, Roy D.; Breivik, Einar; Wilcox, James B.

    2007-01-01

    The relationship between observable responses and the latent constructs they are purported to measure has received considerable attention recently, with particular focus on what has become known as formative measurement. This alternative to reflective measurement in the area of theory-testing research is examined in the context of the potential…

  13. Collective focusing ion accelerator

    International Nuclear Information System (INIS)

    Goldin, F.J.

    1986-01-01

    The principal subject of this dissertation is the trapping confinement of pure electron plasmas in bumpy toroidal magnetic fields, with particular attention given to the trapping procedure and the behavior of the plasma during the final equilibrium. The most important aspects of the equilibrium studied were the qualitative nature of the plasma configuration and motion and its density, distribution and stability. The motivation for this study was that an unneutralized cloud of electrons contained in a toroidal system, sufficiently dense and stable, may serve to electrostatically focus ions (against centrifugal and self space charge forces) in a cyclic ion accelerator. Such an accelerator, known as a Collective Focusing Ion Accelerator (CFIA) could be far smaller than conventional designs (which use external magnetic fields directly to focus the ions) due to the smaller gyro-radium of an electron in a magnetic field of given strength. The electron cloud generally drifted poloidally at a finite radius from the toroidal minor axis. As this would preclude focusing ions with such clouds, damping this motion was investigated. Finite resistance in the normally perfectly conductive vessel wall did this. In further preparation for a working CFIA, additional experiments studied the effect of ions on the stability of the electron cloud

  14. Plasma focus project

    International Nuclear Information System (INIS)

    Sahlin, H.L.

    1975-12-01

    The primary objective of this project is to provide a relatively simple pulsed power source for high density pulsed fusion studies with a variety of DT and other fusion microexplosion targets. The plasma focus operated on DT at 1 MJ should produce greater than or equal to 10 15 DT neutrons per pulse corresponding to 2800 J of nuclear energy release and for low pressure operation and appropriately configured high Z anode center should yield an x-ray burst of about 1000 J with a substantial fraction of this x-ray energy concentrated in the 5-100 kV range. Because of its x-ray and neutron production potential, the operation of the focus as an x-ray source is also under study and an initial design study for a repetitively pulsed 1 MJ plasma focus as a pulsed neutron materials testing source has been completed. The plasma focus seems particularly appropriate for application as a materials testing source for pulsed fusion reactors, for example, based on laser driven fusion microexplosions. The construction status of the device is described

  15. Plutonium focus area. Technology summary

    International Nuclear Information System (INIS)

    1997-09-01

    The Assistant Secretary for the Office of Environmental Management (EM) at the U.S. Department of Energy (DOE) chartered the Plutonium Focus Area (PFA) in October 1995. The PFA open-quotes...provides for peer and technical reviews of research and development in plutonium stabilization activities...close quotes In addition, the PFA identifies and develops relevant research and technology. The purpose of this document is to focus attention on the requirements used to develop research and technology for stabilization, storage, and preparation for disposition of nuclear materials. The PFA Technology Summary presents the approach the PFA uses to identify, recommend, and review research. It lists research requirements, research being conducted, and gaps where research is needed. It also summarizes research performed by the PFA in the traditional research summary format. This document encourages researchers and commercial enterprises to do business with PFA by submitting research proposals or open-quotes white papers.close quotes In addition, it suggests ways to increase the likelihood that PFA will recommend proposed research to the Nuclear Materials Stabilization Task Group (NMSTG) of DOE

  16. Reconsidering formative measurement.

    Science.gov (United States)

    Howell, Roy D; Breivik, Einar; Wilcox, James B

    2007-06-01

    The relationship between observable responses and the latent constructs they are purported to measure has received considerable attention recently, with particular focus on what has become known as formative measurement. This alternative to reflective measurement in the area of theory-testing research is examined in the context of the potential for interpretational confounding and a construct's ability to function as a point variable within a larger model. Although these issues have been addressed in the traditional reflective measurement context, the authors suggest that they are particularly relevant in evaluating formative measurement models. On the basis of this analysis, the authors conclude that formative measurement is not an equally attractive alternative to reflective measurement and that whenever possible, in developing new measures or choosing among alternative existing measures, researchers should opt for reflective measurement. In addition, the authors provide guidelines for researchers dealing with existing formative measures. Copyright 2007 APA, all rights reserved.

  17. Focusing of electromagnetic waves

    International Nuclear Information System (INIS)

    Dhayalan, V.

    1996-01-01

    The focusing of electromagnetic waves inside a slab has been examined together with two special cases in which the slab is reduced to a single interface or a single medium. To that end the exact solutions for the fields inside a layered medium have been used, given in terms of the outside current source in order to obtain the solutions for the focused electric field inside a slab. Both exact and asymptotic solutions of the problem have been considered, and the validity of the latter has been discussed. The author has developed a numerical algorithm for evaluation of the diffraction integral with special emphasis on reducing the computing time. The numerical techniques in the paper can be readily applied to evaluate similar diffraction integrals occurring e.g. in microstrip antennas. 46 refs

  18. Magnetic Focusing Horn

    CERN Multimedia

    1974-01-01

    This magnetic focusing horn was used for the AA (antiproton accumulator). Its development was an important step towards using CERN's Super Proton Synchrotron as a proton - antiproton collider. This eventually led to the discovery of the W and Z particles in 1983. Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet. For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 -, three hundred thousand million - antiprotons.

  19. An adiabatic focuser

    International Nuclear Information System (INIS)

    Chen, P.; Oide, K.; Sessler, A.M.; Yu, S.S.

    1989-08-01

    Theoretical analysis is made of an intense relativistic electron beam, such as would be available from a linear collider, moving through a plasma of increasing density, but density always less than that of the beam (underdense). In this situation, the plasma electrons are expelled from the beam channel and the electrons are subject to an ever-increasing focusing force provided by the channel ions. Analysis is made on the beam radiation energy loss in the classical, the transition, and the quantum regimes. It is shown that the focuser is insensitive to the beam energy spread behaviors in the nonclassical regimes, the radiation limit on lenses (the Oide limit) can be exceeded. The sensitivity of the system to the topic mismatch and the nonlinearity is also analyzed. Examples are given with SLC-type and TLC-type parameters. 9 refs., 1 tab

  20. Line broadening by focusing

    International Nuclear Information System (INIS)

    Brito, A.L. de; Jabs, A.

    1983-01-01

    It is pointed out that the spectral width of a quasi-monochromatic light beam broadens when the beam is focused. A quantitative formula for this broadening is derived from classical wave theory. The effect is shown to explain some experiments on laser beams done by E. Panarella which that author has explained under the ad-hoc hypothesis that the frequency of the photons changes along with the intensity of the light beam. The line broadening by focusing might also contribute to gas ionization by incident light when the ionization potential is well above the mean photon energy. Some remarks are made on some direct applications of the Heisenberg relations in comparison with our treatment. (Author) [pt

  1. Focus on Delivery

    DEFF Research Database (Denmark)

    Hasman, Kirsten; Barfoed, Anne

    Background: Compared to other Nordic countries, Denmark has a high incidence of anal sphincter injury. Recent studies indicate that a strict focus on prevention of severe perineal trauma has decreased the incidence (1). This has resulted in changed clinical procedures in several Danish labour wards...... (2). It is, however, not clarified which of the multifaceted aspects of preventing perineal injury that might explain the decrease (3). Aims: We hypothesized that the use of structured reflection on a clinical practice by midwives and midwifery students would increase both parts’ knowledge on how...... attended the delivery, facilitated the midwife’s and the student’s structured reflection. Further, the project midwife held daily simulation workshops with midwives and students. Two focus group interviews with students and midwives were conducted and analyzed using content analysis. Results and conclusion...

  2. Focus Group Guide

    Science.gov (United States)

    2017-07-01

    home for the arrival of school- aged children. TIP: Do not conduct focus groups in a command conference room in the command group area. Doing so...organizational effectiveness and equal opportunity/equal employment opportunity/fair treatment and sexual assault and response factors (which are listed on the... Sexual Harassment (C) Sex Harassment Retaliation (D) Discrimination - Sex (E) Discrimination - Race (F) Discrimination - Disability (G

  3. Dialogicality in Focus

    DEFF Research Database (Denmark)

    The phenomenon which dialogism addresses is human interaction. It enables us to conceptualise human interaction as intersubjective, symbolic, cultural, transformative and conflictual, in short, as complex. The complexity of human interaction is evident in all domains of human life, for example, i......, because rather than applying dialogism to this or that domain, the present volume focuses on dialogicality itself to interrogate the concepts and methods which are taken for granted in the burgeoning literature. (Imprint: Nova Press)...

  4. Subsurface contaminants focus area

    International Nuclear Information System (INIS)

    1996-08-01

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites

  5. Particle Accelerator Focus Automation

    Science.gov (United States)

    Lopes, José; Rocha, Jorge; Redondo, Luís; Cruz, João

    2017-08-01

    The Laboratório de Aceleradores e Tecnologias de Radiação (LATR) at the Campus Tecnológico e Nuclear, of Instituto Superior Técnico (IST) has a horizontal electrostatic particle accelerator based on the Van de Graaff machine which is used for research in the area of material characterization. This machine produces alfa (He+) and proton (H+) beams of some μA currents up to 2 MeV/q energies. Beam focusing is obtained using a cylindrical lens of the Einzel type, assembled near the high voltage terminal. This paper describes the developed system that automatically focuses the ion beam, using a personal computer running the LabVIEW software, a multifunction input/output board and signal conditioning circuits. The focusing procedure consists of a scanning method to find the lens bias voltage which maximizes the beam current measured on a beam stopper target, which is used as feedback for the scanning cycle. This system, as part of a wider start up and shut down automation system built for this particle accelerator, brings great advantages to the operation of the accelerator by turning it faster and easier to operate, requiring less human presence, and adding the possibility of total remote control in safe conditions.

  6. Particle Accelerator Focus Automation

    Directory of Open Access Journals (Sweden)

    Lopes José

    2017-08-01

    Full Text Available The Laboratório de Aceleradores e Tecnologias de Radiação (LATR at the Campus Tecnológico e Nuclear, of Instituto Superior Técnico (IST has a horizontal electrostatic particle accelerator based on the Van de Graaff machine which is used for research in the area of material characterization. This machine produces alfa (He+ and proton (H+ beams of some μA currents up to 2 MeV/q energies. Beam focusing is obtained using a cylindrical lens of the Einzel type, assembled near the high voltage terminal. This paper describes the developed system that automatically focuses the ion beam, using a personal computer running the LabVIEW software, a multifunction input/output board and signal conditioning circuits. The focusing procedure consists of a scanning method to find the lens bias voltage which maximizes the beam current measured on a beam stopper target, which is used as feedback for the scanning cycle. This system, as part of a wider start up and shut down automation system built for this particle accelerator, brings great advantages to the operation of the accelerator by turning it faster and easier to operate, requiring less human presence, and adding the possibility of total remote control in safe conditions.

  7. Subsurface contaminants focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites.

  8. Focus on Russia

    International Nuclear Information System (INIS)

    Van Koningsbrugge, H.

    2008-01-01

    A few articles in this magazine focus on the developments and policies in Russia. The titles of some of the articles are 'Between state power and liberal reform' on the task of the new Russian president to find a new balance between government interference and market economy; 'Green light for green energy' on the willingness of the Russian government to stimulate renewable energy; 'Russian power play' on the role of Gazprom in the liberalization of the Russian power market; 'Gazprom's risky strategy' on it's pricing strategy

  9. Focus on Organic Conductors

    Directory of Open Access Journals (Sweden)

    Shinya Uji, Takehiko Mori and Toshihiro Takahashi

    2009-01-01

    Full Text Available Organic materials are usually thought of as electrical insulators. Progress in chemical synthesis, however, has brought us a rich variety of conducting organic materials, which can be classified into conducting polymers and molecular crystals. Researchers can realize highly conducting molecular crystals in charge-transfer complexes, where suitable combinations of organic electron donor or acceptor molecules with counter ions or other organic molecules provide charge carriers. By means of a kind of chemical doping, the charge-transfer complexes exhibit high electrical conductivity and, thanks to their highly crystalline nature, even superconductivity has been observed. This focus issue of Science and Technology of Advanced Materials is devoted to the research into such 'organic conductors'The first organic metal was (TTF(TCNQ, which was found in 1973 to have high conductivity at room temperature and a metal–insulator transition at low temperatures. The first organic superconductor was (TMTSF2PF6, whose superconductivity under high pressures was reported by J´erome in 1980. After these findings, the research on organic conductors exploded. Hundreds of organic conductors have been reported, among which more than one hundred exhibit superconductivity. Recently, a single-component organic conductor has been found with metallic conductivity down to low temperatures.In these organic conductors, in spite of their simple electronic structures, much new physics has arisen from the low dimensionality. Examples are charge and spin density waves, characteristic metal–insulator transitions, charge order, unconventional superconductivity, superconductor–insulator transitions, and zero-gap conductors with Dirac cones. The discovery of this new physics is undoubtedly derived from the development of many intriguing novel organic conductors. High quality single crystals are indispensable to the precise measurement of electronic states.This focus issue

  10. Rheological phenomena in focus

    CERN Document Server

    Boger, DV

    1993-01-01

    More than possibly any other scientific discipline, rheology is easily visualized and the relevant literature contains many excellent photographs of unusual and often bizarre phenomena. The present book brings together these photographs for the first time. They are supported by a full explanatory text. Rheological Phenomena in Focus will be an indispensable support manual to all those who teach rheology or have to convince colleagues of the practical relevance of the subject within an industrial setting. For those who teach fluid mechanics, the book clearly illustrates the difference be

  11. Formative (measurement)

    NARCIS (Netherlands)

    Fassott, G.; Henseler, Jörg; Cooper, C.; Lee, N.; Farrell, A.

    2015-01-01

    When using measurement models with multiple indicators, researchers need to decide about the epistemic relationship between the latent variable and its indicators. In this article, we describe the nature, the estimation, the characteristics, and the validity assessment of formative measurement

  12. From Sermon Formation to Preacher Formation

    DEFF Research Database (Denmark)

    Gaarden, Marianne

    2016-01-01

    today is less about exercising the authority of an office and more about embodying authenticity. I argue that traditional homiletic education can benefit from implementing a learner-centered approach to teaching moving from sermon formation towards preacher formation, in order to develop and train...... preachers. This involves a learning strategy to ministry where theological skills, pastoral competences, and own personality are interwoven. Teaching here means facilitating a room of learning where teacher’s power and control is reduced, allowing the preacher to reflect upon own practice without being...... judged, evaluated, or critiqued. In this paper, I explain how a learner-centered approach to education works in practice and show how pastors experience the teaching method and the congregations’ positive response to their improvements. I shall present the results of a focus-group interview with pastors...

  13. Doing focus group research

    DEFF Research Database (Denmark)

    Lindegaard, Laura Bang

    2014-01-01

    Scholars of ethnomethodologically informed discourse studies are often sceptical of the use of interview data such as focus group data. Some scholars quite simply reject interview data with reference to a general preference for so-called naturally occurring data. Other scholars acknowledge...... that interview data can be of some use if the distinction between natural and contrived data is given up and replaced with a distinction between interview data as topic or as resource. In greater detail, such scholars argue that interview data are perfectly adequate if the researcher wants to study the topic...... of interview interaction, but inadequate as data for studying phenomena that go beyond the phenomenon of interview interaction. Neither of these more and less sceptical positions are, on the face of it, surprising due to the ethnomethodological commitment to study social order as accomplished in situ...

  14. Focus on Succes

    Directory of Open Access Journals (Sweden)

    Ivan Slimák

    2011-10-01

    Full Text Available The Editor wishes to present the need and form of turning the focus of individuals and organisations to success, based on evaluating understanding of the situation, on complex improving the quality of work, production and life, and on awareness of accountability for consequences of one’s actions in the given environment and time. Understood by success is sustained financial and non-financial prosperity, whilst decisive is the evaluating process, the key element is loyalty of natural and physical persons, and the priority is loyalty of external customers. The address is targeted to would-be authors and readers of our Journal interested in engineering and management of quality of mutually correlate entities.

  15. Cosmological Final Focus Systems

    International Nuclear Information System (INIS)

    Irwin, J

    2004-01-01

    We develop the many striking parallels between the dynamics of light streams from distant galaxies and particle beams in accelerator final focus systems. Notably the deflections of light by mass clumps are identical to the kicks arising from the long-range beam-beam interactions of two counter-rotating particle beams (known as parasitic crossings). These deflections have sextupolar as well as quadrupolar components. We estimate the strength of such distortions for a variety of circumstances and argue that the sextupolar distortions from clumping within clusters may be observable. This possibility is enhanced by the facts that (1) the sextupolar distortions of background galaxies is a factor of 5 smaller than the quadrupolar distortion, (2) the angular orientation of the sextupolar and quadrupolar distortions from a mass distribution would be correlated, appearing as a slightly curved image, (3) these effects should be spatially clumped on the sky

  16. The FOCUS trial

    DEFF Research Database (Denmark)

    Glenthøj, Louise B; Fagerlund, Birgitte; Randers, Lasse

    2015-01-01

    BACKGROUND: Cognitive deficits are a distinct feature among people at ultra-high risk (UHR) for psychosis and pose a barrier to functional recovery. Insufficient evidence exists on how to ameliorate these cognitive deficits in patients at UHR for psychosis and hence improve daily living and quality...... of life. The aim of the trial is to investigate whether cognitive remediation can improve cognitive and psychosocial function in patients at UHR for psychosis. METHODS: The FOCUS trial (Function and Overall Cognition in Ultra-high risk States) is a randomised, parallel group, observer-blinded clinical...... trial enrolling 126 patients meeting the standardised criteria of being at UHR for psychosis. Patients are recruited from psychiatric in- and outpatient facilities in the Copenhagen catchment area. Patients are randomised to one of the two treatment arms: cognitive remediation plus standard treatment...

  17. Focusing on customer service.

    Science.gov (United States)

    1996-01-01

    This booklet is devoted to a consideration of how good customer service in family planning programs can generate demand for products and services, bring customers back, and reduce costs. Customer service is defined as increasing client satisfaction through continuous concern for client preferences, staff accountability to clients, and respect for the rights of clients. Issues discussed include the introduction of a customer service approach and gaining staff commitment. The experience of PROSALUD in Bolivia in recruiting appropriate staff, supervising staff, soliciting client feedback, and marketing services is offered as an example of a successful customer service approach. The key customer service functions are described as 1) establishing a welcoming atmosphere, 2) streamlining client flow, 3) personalizing client services, and 4) organizing and providing clear information to clients. The role of the manager in developing procedures is explored, and the COPE (Client-Oriented Provider-Efficient) process is presented as a good way to begin to make improvements. Techniques in staff training in customer service include brainstorming, role playing, using case studies (examples of which are provided), and engaging in practice sessions. Training also leads to the development of effective customer service attitudes, and the differences between these and organizational/staff-focused attitudes are illustrated in a chart. The use of communication skills (asking open-ended questions, helping clients express their concerns, engaging in active listening, and handling difficult situations) is considered. Good recovery skills are important when things go wrong. Gathering and using client feedback is the next topic considered. This involves identifying, recording, and discussing customer service issues as well as taking action on these issues and evaluating the results. The booklet ends by providing a sample of customer service indicators, considering the maintenance of a

  18. Cement Formation

    DEFF Research Database (Denmark)

    Telschow, Samira; Jappe Frandsen, Flemming; Theisen, Kirsten

    2012-01-01

    Cement production has been subject to several technological changes, each of which requires detailed knowledge about the high multiplicity of processes, especially the high temperature process involved in the rotary kiln. This article gives an introduction to the topic of cement, including...... an overview of cement production, selected cement properties, and clinker phase relations. An extended summary of laboratory-scale investigations on clinkerization reactions, the most important reactions in cement production, is provided. Clinker formations by solid state reactions, solid−liquid and liquid......−liquid reactions are discussed, as are the influences of particles sizes on clinker phase formation. Furthermore, a mechanism for clinker phase formation in an industrial rotary kiln reactor is outlined....

  19. Galaxy Formation

    DEFF Research Database (Denmark)

    Sparre, Martin

    Galaxy formation is an enormously complex discipline due to the many physical processes that play a role in shaping galaxies. The objective of this thesis is to study galaxy formation with two different approaches: First, numerical simulations are used to study the structure of dark matter and how...... galaxies form stars throughout the history of the Universe, and secondly it is shown that observations of gamma-ray bursts (GRBs) can be used to probe galaxies with active star formation in the early Universe. A conclusion from the hydrodynamical simulations is that the galaxies from the stateof...... is important, since it helps constraining chemical evolution models at high redshift. A new project studying how the population of galaxies hosting GRBs relate to other galaxy population is outlined in the conclusion of this thesis. The core of this project will be to quantify how the stellar mass function...

  20. Comet formation

    Science.gov (United States)

    Blum, J.

    2014-07-01

    There has been vast progress in our understanding of planetesimal formation over the past decades, owing to a number of laboratory experiments as well as to refined models of dust and ice agglomeration in protoplanetary disks. Coagulation rapidly forms cm-sized ''pebbles'' by direct sticking in collisions at low velocities (Güttler et al. 2010; Zsom et al. 2010). For the further growth, two model approaches are currently being discussed: (1) Local concentration of pebbles in nebular instabilities until gravitational instability occurs (Johansen et al. 2007). (2) A competition between fragmentation and mass transfer in collisions among the dusty bodies, in which a few ''lucky winners'' make it to planetesimal sizes (Windmark et al. 2012a,b; Garaud et al. 2013). Predictions of the physical properties of the resulting bodies in both models allow a distinction of the two formation scenarios of planetesimals. In particular, the tensile strength (i.e, the inner cohesion) of the planetesimals differ widely between the two models (Skorov & Blum 2012; Blum et al. 2014). While model (1) predicts tensile strengths on the order of ˜ 1 Pa, model (2) results in rather compactified dusty bodies with tensile strengths in the kPa regime. If comets are km-sized survivors of the planetesimal-formation era, they should in principle hold the secret of their formation process. Water ice is the prime volatile responsible for the activity of comets. Thermophysical models of the heat and mass transport close to the comet-nucleus surface predict water-ice sublimation temperatures that relate to maximum sublimation pressures well below the kPa regime predicted for formation scenario (2). Model (1), however, is in agreement with the observed dust and gas activity of comets. Thus, a formation scenario for cometesimals involving gravitational instability is favored (Blum et al. 2014).

  1. FOCUS ON GRAPHENE

    International Nuclear Information System (INIS)

    Peres, N M R; Ribeiro, Ricardo M

    2009-01-01

    Graphene physics is currently one of the most active research areas in condensed matter physics. Countless theoretical and experimental studies have already been performed, targeting electronic, magnetic, thermal, optical, structural and vibrational properties. Also, studies that modify pristine graphene, aiming at finding new physics and possible new applications, have been considered. These include patterning nanoribbons and quantum dots, exposing graphene's surface to different chemical species, studying multilayer systems, and inducing strain and curvature (modifying in this way graphene's electronic properties). This focus issue includes many of the latest developments on graphene research. Focus on Graphene Contents The effect of sublattice symmetry breaking on the electronic properties of doped graphene A Qaiumzadeh and R Asgari Interfaces within graphene nanoribbons J Wurm, M Wimmer, I Adagideli, K Richter and H U Baranger Weak localization and transport gap in graphene antidot lattices J Eroms and D Weiss Electronic properties of graphene antidot lattices J A Fuerst, J G Pedersen, C Flindt, N A Mortensen, M Brandbyge, T G Pedersen and A-P Jauho Splitting of critical energies in the n=0 Landau level of graphene Ana L C Pereira Double-gated graphene-based devices S Russo, M F Craciun, M Yamamoto, S Tarucha and A F Morpurgo Pinning and switching of magnetic moments in bilayer graphene Eduardo V Castro, M P Lopez-Sancho and M A H Vozmediano Electronic transport properties of graphene nanoribbons Katsunori Wakabayashi, Yositake Takane, Masayuki Yamamoto and Manfred Sigrist Many-body effects on out-of-plane phonons in graphene J Gonzalez and E Perfetto Graphene zigzag ribbons, square lattice models and quantum spin chains Mahdi Zarea and Nancy Sandler On the universal ac optical background in graphene V P Gusynin, S G Sharapov and J P Carbotte Heat conduction in graphene: experimental study and theoretical interpretation S Ghosh, D L Nika, E P Pokatilov and A A

  2. Stress wave focusing transducers

    Energy Technology Data Exchange (ETDEWEB)

    Visuri, S.R., LLNL

    1998-05-15

    Conversion of laser radiation to mechanical energy is the fundamental process behind many medical laser procedures, particularly those involving tissue destruction and removal. Stress waves can be generated with laser radiation in several ways: creation of a plasma and subsequent launch of a shock wave, thermoelastic expansion of the target tissue, vapor bubble collapse, and ablation recoil. Thermoelastic generation of stress waves generally requires short laser pulse durations and high energy density. Thermoelastic stress waves can be formed when the laser pulse duration is shorter than the acoustic transit time of the material: {tau}{sub c} = d/c{sub s} where d = absorption depth or spot diameter, whichever is smaller, and c{sub s} = sound speed in the material. The stress wave due to thermoelastic expansion travels at the sound speed (approximately 1500 m/s in tissue) and leaves the site of irradiation well before subsequent thermal events can be initiated. These stress waves, often evolving into shock waves, can be used to disrupt tissue. Shock waves are used in ophthalmology to perform intraocular microsurgery and photodisruptive procedures as well as in lithotripsy to fragment stones. We have explored a variety of transducers that can efficiently convert optical to mechanical energy. One such class of transducers allows a shock wave to be focused within a material such that the stress magnitude can be greatly increased compared to conventional geometries. Some transducer tips could be made to operate regardless of the absorption properties of the ambient media. The size and nature of the devices enable easy delivery, potentially minimally-invasive procedures, and precise tissue- targeting while limiting thermal loading. The transducer tips may have applications in lithotripsy, ophthalmology, drug delivery, and cardiology.

  3. Focus Groups as Transformative Spiritual Encounters

    Directory of Open Access Journals (Sweden)

    Sharon Moloney PhD

    2011-03-01

    Full Text Available Focus groups are a valuable method for exploring the construction and negotiation of meanings. In her doctoral research the author explored how Australian women's experiences of menstruation, birth, and spirituality are invested with meaning and how that meaning influences and shapes those experiences. The focus group has been described as a potentially liminal space, which enables the discussion of taboo subjects by breaking the ice and giving people permission to comment. In addition, she discovered that the groups could be occasions of empowerment and transformation for both participants and researcher. In a way that far exceeded her expectations, the group format was ideally suited to feminist research and the organic inquiry methodology she used. Some groups became deeply spiritual encounters that were nourishing and transformative for all. This article explores how focus groups can be vehicles of spiritual transformation, examining one group in particular to highlight the points raised.

  4. Some optical diagnostics for the plasma focus

    International Nuclear Information System (INIS)

    Korzhavin, V.M.

    1980-01-01

    Some aspects of studying plasma focus dynamics are reported. Particular efforts were made to develop an infrared (IR) diagnostics. The plasma focus is formed in a discharge chamber, when shock waves and plasma sheath cumulate on the axis as a result of the break-down of filling gas by the application of high voltage. The current J was measured with a Rogovsky coil, and the voltage U was measured with a capacitor divider. The current derivative was measured with magnetic probes, and X-ray and neutron emission intensities were measured with a plastic scintillator. The total neutron yield were measured by the activation method. The time-integrated soft X-ray pictures of plasma focus were taken with a pin-hole camera. The formation and disruption of plasma focus were studied by multi-picture speed photography. Laser interferometry was used to study the time-space distribution of plasma density. For the study of turbulence phenomena in plasma focus, a new type IR detector was employed. The results of measurements suggest that there exists some superthermal radiation during the second compression of plasma focus, but it is not so strong. (Kato, T.)

  5. String Formatting Considered Harmful for Novice Programmers

    Science.gov (United States)

    Hughes, Michael C.; Jadud, Matthew C.; Rodrigo, Ma. Mercedes T.

    2010-01-01

    In Java, "System.out.printf" and "String.format" consume a specialised kind of string commonly known as a format string. In our study of first-year students at the Ateneo de Manila University, we discovered that format strings present a substantial challenge for novice programmers. Focusing on their first laboratory we found…

  6. Focusators for laser-branding

    Science.gov (United States)

    Doskolovich, L. L.; Kazanskiy, N. L.; Kharitonov, S. I.; Uspleniev, G. V.

    A new method is investigated for synthesis of computer-generated optical elements: focusators that are able to focus the radial-symmetrical laser beam into complex focal contours, in particular into alphanumeric symbols. The method is based on decomposition of the focal contour into segments of straight lines and semi-circles, following corresponding spacing out of the focusator on elementary segments (concentric rings or sectors) and solution of the inverse task of focusing from focusator segments into corresponding elements of the focal contour. The results of numerical computing of the field from synthesized focusators into the letters are presented. The theoretical efficiency of the focusators discussed is no less than 85%. The amplitude masks and the results of operational studies of synthesized focusators are presented.

  7. Planet Formation

    Science.gov (United States)

    Podolak, Morris

    2018-04-01

    Modern observational techniques are still not powerful enough to directly view planet formation, and so it is necessary to rely on theory. However, observations do give two important clues to the formation process. The first is that the most primitive form of material in interstellar space exists as a dilute gas. Some of this gas is unstable against gravitational collapse, and begins to contract. Because the angular momentum of the gas is not zero, it contracts along the spin axis, but remains extended in the plane perpendicular to that axis, so that a disk is formed. Viscous processes in the disk carry most of the mass into the center where a star eventually forms. In the process, almost as a by-product, a planetary system is formed as well. The second clue is the time required. Young stars are indeed observed to have gas disks, composed mostly of hydrogen and helium, surrounding them, and observations tell us that these disks dissipate after about 5 to 10 million years. If planets like Jupiter and Saturn, which are very rich in hydrogen and helium, are to form in such a disk, they must accrete their gas within 5 million years of the time of the formation of the disk. Any formation scenario one proposes must produce Jupiter in that time, although the terrestrial planets, which don't contain significant amounts of hydrogen and helium, could have taken longer to build. Modern estimates for the formation time of the Earth are of the order of 100 million years. To date there are two main candidate theories for producing Jupiter-like planets. The core accretion (CA) scenario supposes that any solid materials in the disk slowly coagulate into protoplanetary cores with progressively larger masses. If the core remains small enough it won't have a strong enough gravitational force to attract gas from the surrounding disk, and the result will be a terrestrial planet. If the core grows large enough (of the order of ten Earth masses), and the disk has not yet dissipated, then

  8. Prosodic Focus Marking in Bai.

    NARCIS (Netherlands)

    Liu, Zenghui; Chen, A.; Van de Velde, Hans

    2014-01-01

    This study investigates prosodic marking of focus in Bai, a Sino-Tibetan language spoken in the Southwest of China, by adopting a semi-spontaneous experimental approach. Our data show that Bai speakers increase the duration of the focused constituent and reduce the duration of the post-focus

  9. Galaxy Formation

    CERN Document Server

    Longair, Malcolm S

    2008-01-01

    This second edition of Galaxy Formation is an up-to-date text on astrophysical cosmology, expounding the structure of the classical cosmological models from a contemporary viewpoint. This forms the background to a detailed study of the origin of structure and galaxies in the Universe. The derivations of many of the most important results are derived by simple physical arguments which illuminate the results of more advanced treatments. A very wide range of observational data is brought to bear upon these problems, including the most recent results from WMAP, the Hubble Space Telescope, galaxy surveys like the Sloan Digital Sky Survey and the 2dF Galaxy Redshift Survey, studies of Type 1a supernovae, and many other observations.

  10. Galaxy formation

    International Nuclear Information System (INIS)

    Gribbin, J.

    1979-01-01

    The current debate on the origin and evolution of galaxies is reviewed and evidence to support the so-called 'isothermal' and 'adiabatic' fluctuation models considered. It is shown that new theories have to explain the formation of both spiral and elliptical galaxies and the reason for their differences. It is stated that of the most recent models the best indicates that rotating spiral galaxies are formed naturally when gas concentrates in the centre of a great halo and forms stars while ellipticals are explained by later interactions between spiral galaxies and merging, which can cancel out the rotation while producing an elliptical galaxy in which the stars, coming from two original galaxies, follow very elliptical, anisotropic orbits. (UK)

  11. Habit formation.

    Science.gov (United States)

    Smith, Kyle S; Graybiel, Ann M

    2016-03-01

    Habits, both good ones and bad ones, are pervasive in animal behavior. Important frameworks have been developed to understand habits through psychological and neurobiological studies. This work has given us a rich understanding of brain networks that promote habits, and has also helped us to understand what constitutes a habitual behavior as opposed to a behavior that is more flexible and prospective. Mounting evidence from studies using neural recording methods suggests that habit formation is not a simple process. We review this evidence and take the position that habits could be sculpted from multiple dissociable changes in neural activity. These changes occur across multiple brain regions and even within single brain regions. This strategy of classifying components of a habit based on different brain signals provides a potentially useful new way to conceive of disorders that involve overly fixed behaviors as arising from different potential dysfunctions within the brain's habit network.

  12. Habit formation

    Science.gov (United States)

    Smith, Kyle S.; Graybiel, Ann M.

    2016-01-01

    Habits, both good ones and bad ones, are pervasive in animal behavior. Important frameworks have been developed to understand habits through psychological and neurobiological studies. This work has given us a rich understanding of brain networks that promote habits, and has also helped us to understand what constitutes a habitual behavior as opposed to a behavior that is more flexible and prospective. Mounting evidence from studies using neural recording methods suggests that habit formation is not a simple process. We review this evidence and take the position that habits could be sculpted from multiple dissociable changes in neural activity. These changes occur across multiple brain regions and even within single brain regions. This strategy of classifying components of a habit based on different brain signals provides a potentially useful new way to conceive of disorders that involve overly fixed behaviors as arising from different potential dysfunctions within the brain's habit network. PMID:27069378

  13. Virtual Focus Groups: New Frontiers in Research

    Directory of Open Access Journals (Sweden)

    Lyn Turney

    2005-06-01

    Full Text Available New information and communication technologies in the form of learning management systems provide unique and inventive opportunities for qualitative researchers. Their intrinsic ability to record discursive data in text format accurately and to provide safe, secure, and anonymous environments for participants makes them amenable for use as advanced research tools. In this article, the authors report on a collaborative project that tested the potential of online discussion boards for use in virtual focus groups. What the researchers found was that not only was the method theoretically sound, it actually enhanced their ability to connect with difficult-to-access populations that were disparately spread.

  14. EDITORIAL: Focus on Carbon Nanotubes

    Science.gov (United States)

    2003-09-01

    The study of carbon nanotubes, since their discovery by Iijima in 1991, has become a full research field with significant contributions from all areas of research in solid-state and molecular physics and also from chemistry. This Focus Issue in New Journal of Physics reflects this active research, and presents articles detailing significant advances in the production of carbon nanotubes, the study of their mechanical and vibrational properties, electronic properties and optical transitions, and electrical and transport properties. Fundamental research, both theoretical and experimental, represents part of this progress. The potential applications of nanotubes will rely on the progress made in understanding their fundamental physics and chemistry, as presented here. We believe this Focus Issue will be an excellent guide for both beginners and experts in the research field of carbon nanotubes. It has been a great pleasure to edit the many excellent contributions from Europe, Japan, and the US, as well from a number of other countries, and to witness the remarkable effort put into the manuscripts by the contributors. We thank all the authors and referees involved in the process. In particular, we would like to express our gratitude to Alexander Bradshaw, who invited us put together this Focus Issue, and to Tim Smith and the New Journal of Physics staff for their extremely efficient handling of the manuscripts. Focus on Carbon Nanotubes Contents Transport theory of carbon nanotube Y junctions R Egger, B Trauzettel, S Chen and F Siano The tubular conical helix of graphitic boron nitride F F Xu, Y Bando and D Golberg Formation pathways for single-wall carbon nanotube multiterminal junctions Inna Ponomareva, Leonid A Chernozatonskii, Antonis N Andriotis and Madhu Menon Synthesis and manipulation of carbon nanotubes J W Seo, E Couteau, P Umek, K Hernadi, P Marcoux, B Lukic, Cs Mikó, M Milas, R Gaál and L Forró Transitional behaviour in the transformation from active end

  15. Energy coupling in the plasma focus

    International Nuclear Information System (INIS)

    Wainwright, T.E.; Pickles, W.L.; Sahlin, H.L.; Price, D.F.

    1979-01-01

    Experiments have been performed with a 125-kJ plasma focus to investigate mechanisms for rapid coupling of inductively-stored energy into plasmas. The coupling can take place through the formation of an electron or ion beam that deposits its energy in a target or directly by the penetration of the magnetic field into a resistive plasma. Some preliminary results from experiments of both types are described. The experiments use a replaceable conical anode tip that is intended to guide the focus to within a few millimeters of the axis, where it can suddenly deliver energy either to a small target or to particles that are accelerated. X-ray and fast-ion diagnostics have been used to study the effects

  16. Focus Groups Help To Focus the Marketing Strategy.

    Science.gov (United States)

    Ashar, Hanna; Lane, Maureen

    1996-01-01

    A university-based degree completion program for adults conducted focus group research to refine market positioning and promotion. Focus groups averaged five current students and recent graduates who reflected, demographically, the current student population. Results gave insight into reasons for selecting the university, aspects of the program…

  17. Discrete and modal focusing effects: principles and applications

    International Nuclear Information System (INIS)

    Stamate, E

    2012-01-01

    Charge flux distribution on the surface of biased electrodes of different geometries immersed in a plasma is investigated by three-dimensional simulations and experiments. It is demonstrated that the sheath surrounding the electrodes that interface insulators acts as an electrostatic lens, focusing the charges to distinct locations on the electrode surface depending on the entrance coordinates at the sheath edge. Two focusing effects are identified. Discrete focusing leads to the formation of a passive surface of no ion impact, near the edge of the electrodes interfacing insulators. Modal focusing results in the formation of certain ‘modal spots’ and/or ‘modal lines’. Several phenomenological aspects and potential applications are reviewed and further discussed, including charge focusing by a three-dimensional plasma–sheath–lens, ion dose uniformity during plasma immersion ion implantation, mass spectrometry and plasma monitoring. (paper)

  18. Discrete and modal focusing effects: principles and applications

    DEFF Research Database (Denmark)

    Stamate, Eugen

    2012-01-01

    Charge flux distribution on the surface of biased electrodes of different geometries immersed in a plasma is investigated by three-dimensional simulations and experiments. It is demonstrated that the sheath surrounding the electrodes that interface insulators acts as an electrostatic lens, focusing...... the charges to distinct locations on the electrode surface depending on the entrance coordinates at the sheath edge. Two focusing effects are identified. Discrete focusing leads to the formation of a passive surface of no ion impact, near the edge of the electrodes interfacing insulators. Modal focusing...... results in the formation of certain ‘modal spots’ and/or ‘modal lines’. Several phenomenological aspects and potential applications are reviewed and further discussed, including charge focusing by a three-dimensional plasma–sheath–lens, ion dose uniformity during plasma immersion ion implantation, mass...

  19. Regulatory focus in groupt contexts

    NARCIS (Netherlands)

    Faddegon, Krispijn Johannes

    2009-01-01

    The thesis examines the influence of group processes on the regulatory focus of individual group members. It is demonstrated that the group situation can affect group members' regulatory focus both in a top-down fashion (via the identitiy of the group) and in a bottom-up fashion (emerging from the

  20. CTE's Focus on Continuous Improvement

    Science.gov (United States)

    Foster, John; Kelley, Patricia; Pritz, Sandy; Hodes, Carol

    2011-01-01

    Just one of the ways career and technical education (CTE) is revamping its image is through increased attention to data-driven instructional techniques as a means of improving and focusing instruction on what matters most. Accountability and data have increasingly become a core focus of research, news, and commentary about education in recent…

  1. On the Semantics of Focus

    Science.gov (United States)

    Kess, Joseph F.

    1975-01-01

    This article discusses the semantics of the notion of focus, insofar as it relates to Filipino languages. The evolution of this notion is reviewed, and an alternative explanation of it is given, stressing the fact that grammar and semantics should be kept separate in a discussion of focus. (CLK)

  2. Intensity dependence of focused ultrasound lesion position

    Science.gov (United States)

    Meaney, Paul M.; Cahill, Mark D.; ter Haar, Gail R.

    1998-04-01

    Knowledge of the spatial distribution of intensity loss from an ultrasonic beam is critical to predicting lesion formation in focused ultrasound surgery. To date most models have used linear propagation models to predict the intensity profiles needed to compute the temporally varying temperature distributions. These can be used to compute thermal dose contours that can in turn be used to predict the extent of thermal damage. However, these simulations fail to adequately describe the abnormal lesion formation behavior observed for in vitro experiments in cases where the transducer drive levels are varied over a wide range. For these experiments, the extent of thermal damage has been observed to move significantly closer to the transducer with increasing transducer drive levels than would be predicted using linear propagation models. The simulations described herein, utilize the KZK (Khokhlov-Zabolotskaya-Kuznetsov) nonlinear propagation model with the parabolic approximation for highly focused ultrasound waves, to demonstrate that the positions of the peak intensity and the lesion do indeed move closer to the transducer. This illustrates that for accurate modeling of heating during FUS, nonlinear effects must be considered.

  3. Plasma focus as an heavy ion source in the problem of heavy ion fusion

    International Nuclear Information System (INIS)

    Gribkov, V.A.; Dubrovskij, A.V.; Kalachev, N.V.; Krokhin, O.N.; Silin, P.V.; Nikulin, V.Ya.; Cheblukov, Yu.N.

    1984-01-01

    Results of experiments on the ion flux formation in a plasma focus (PF) to develop a multicharged ion source for thermonuclear facility driver are presented. In plasma focus accelerating section copper ions were injected. Advantages of the suggested method of ion beam formation are demonstrated. Beam emittance equalling < 0.1 cmxmrad is obtained. Plasma focus ion energy exceeds 1 MeV. Plasma focus in combination with a neodymium laser is thought to be a perspective ion source for heavy ion fusion

  4. Electric motors in the focus; Elektroantrieb im Focus

    Energy Technology Data Exchange (ETDEWEB)

    Wilms, Jan

    2013-05-15

    In August 2013, the first electric series production model of Ford comes to the market: the Focus Electric. A 23-kWh lithium-ion battery supplies the 107 kilowatts (145 hp) electric motor of the Focus Electric with energy. This battery enables a range of 162 kilometers and a limited top speed of 136 kilometers per hour. However, with 40,000 Euro this electric-powered vehicles is too expensive.

  5. Plutonium focus area: Technology summary

    International Nuclear Information System (INIS)

    1996-03-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this approach, EM developed a management structure and principles that led to creation of specific focus areas. These organizations were designed to focus scientific and technical talent throughout DOE and the national scientific community on major environmental restoration and waste management problems facing DOE. The focus area approach provides the framework for inter-site cooperation and leveraging of resources on common problems. After the original establishment of five major focus areas within the Office of Technology Development (EM-50), the Nuclear Materials Stabilization Task Group (NMSTG, EM-66) followed EM-50's structure and chartered the Plutonium Focus Area (PFA). NMSTG's charter to the PFA, described in detail later in this book, plays a major role in meeting the EM-66 commitments to the Defense Nuclear Facilities Safety Board (DNFSB). The PFA is a new program for FY96 and as such, the primary focus of revision 0 of this Technology Summary is an introduction to the Focus Area; its history, development, and management structure, including summaries of selected technologies being developed. Revision 1 to the Plutonium Focus Area Technology Summary is slated to include details on all technologies being developed, and is currently planned for release in August 1996. The following report outlines the scope and mission of the Office of Environmental Management, EM-60, and EM-66 organizations as related to the PFA organizational structure

  6. Compact electron beam focusing column

    Science.gov (United States)

    Persaud, Arun; Leung, Ka-Ngo; Reijonen, Jani

    2001-12-01

    A novel design for an electron beam focusing column has been developed at LBNL. The design is based on a low-energy spread multicusp plasma source which is used as a cathode for electron beam production. The focusing column is 10 mm in length. The electron beam is focused by means of electrostatic fields. The column is designed for a maximum voltage of 50 kV. Simulations of the electron trajectories have been performed by using the 2D simulation code IGUN and EGUN. The electron temperature has also been incorporated into the simulations. The electron beam simulations, column design and fabrication will be discussed in this presentation.

  7. Focusing liquid microjets with nozzles

    International Nuclear Information System (INIS)

    Acero, A J; Ferrera, C; Montanero, J M; Gañán-Calvo, A M

    2012-01-01

    The stability of flow focusing taking place in a converging–diverging nozzle, as well as the size of the resulting microjets, is examined experimentally in this paper. The results obtained in most aspects of the problem are similar to those of the classical plate-orifice configuration. There is, however, a notable difference between flow focusing in nozzles and in the plate-orifice configuration. In the former case, the liquid meniscus oscillates laterally (global whipping) for a significant area of the control parameter plane, a phenomenon never observed when focusing with the plate-orifice configuration. Global whipping may constitute an important drawback of flow focusing with nozzles because it reduces the robustness of the technique. (paper)

  8. Wayside Teaching: Focusing on Relationships

    Science.gov (United States)

    Powell, Sara Davis

    2011-01-01

    Wayside teaching focuses on building and maintaining positive relationships with students. Teachers can implement certain wayside teaching practices to end the year in a positive way and begin preparing for the next school year.

  9. A study of plasma focus

    International Nuclear Information System (INIS)

    Hirano, Katsumi; Majima, Kazuo

    1976-01-01

    The behavior of the plasma acceleration between electrodes, the phenomena due to the pinch effect at the top of the electrodes and the neutron emission mechanism were experimentally studied. The plasma focus device was a Mather type coaxial discharge device, and the instruments used for the present purpose were a Rogoski coil, an image converter camera, a scintillation detector and a silver foil activation counter. The results of the present experiment were as follows. Plasma focus was not definitely made under the same condition. When the focus was seen, a dip was observed in the discharge wave form, and the emissions of X-ray and neutrons were detected. The angular anisotropy of neutron emission was observed, and corresponds to a beam target model. The phenomena showing the occurrence of focus were seen, when the current sheet was produced at a delayed time after discharge, and arrived at the muzzle with large velocity. The relation between the number of emitted neutrons and the velocity of the current sheet was obtained, whereas no systematic relation exists between the number of emitted neutrons and the velocity of pinch. When the focus was not observed, no dip was seen in current wave form, and the emissions of X-ray and neutrons were not detected. The reason of no focus was considered. (Kato, T.)

  10. Sausage instability threshold in a low energy plasma focus

    International Nuclear Information System (INIS)

    Zakaullah, M.; Nasir, M.; Khattak, F.Y.; Murtaza, G.

    1993-01-01

    Development of sausage instability (m = 0 mode) is studied in a small low energy Mather-type plasma focus. A shadow graphic study of the current sheath has shown that the focused plasma necks off during the radial phase before the maximum compression. This may indicate the lowering of the instability threshold. Three hook-type structures are observed which may not be due to the multifoci formation. The bubble shape structure is observed to be developed in the expansion phase. (author)

  11. Network Formation under the Threat of Disruption

    NARCIS (Netherlands)

    Hoyer, B.

    2013-01-01

    The studies in this thesis are focused on the impact the presence of a network disruptor has on network formation models. In particular, we build two theoretical models to study the effect of network disruption on network formation and test the effect network disruption has on equilibrium selection

  12. Stability of expanded plasma focus

    International Nuclear Information System (INIS)

    Soliman, H.M.

    1994-01-01

    In this study, the stabilization of the expanded plasma focus formed by 4.5 kJ plasma focus device of Mather type by magnetic field is presented. The experimental results of the induced axial magnetic field and electric probe measurements of the expanded plasma focus show that, the plasma consists of three plasmoids, electron temperature measurements off the plasmoids at a point close to the muzzle are 26 eV, 30 eV and 27 eV respectively and the electron densities are 6.6 x 10 14 , 6.1 x 10 14 / cm 3 respectively. The presence of external axial magnetic field (B 2 = 1.6 kg) at the mid distance between the breech and the muzzle has a less effect on the stability of expanded focus and it causes a restriction for the plasma motion. the electron temperature of the three plasmoids are found to increase in that case by 23%, 18.5% respectively. When this axial magnetic field is applied at the muzzle end, it leads to a more stable expanded plasma focus which consists mainly of one plasmoid with electron temperature of 39 eV and density of 3.4 x 10 14 / cm 3 . 5 figs

  13. Verum focus and polar questions

    Directory of Open Access Journals (Sweden)

    Ion Giurgea

    2012-11-01

    Full Text Available We argue that some word order phenomena in Romanian and Sardinian are the result of a checking operation in the left periphery involving verum focus (i.e. focus on the polarity component of the sentence. In particular, this operation accounts for some word order patterns found in polar questions. In Romanian, polarity fronting is realized as head-movement of (V+T to a higher peripheral head which bears a Focus-probe. This licenses VS orders for predications in which VS is not allowed as a neutral order (i-level predicates, iteratives, generics. In Sardinian, an entire phrase headed by the lexical predicate (verbal non-finite form or non-verbal predicate is fronted before the auxiliary. We argue that this order is obtained by two movement operations, head-raising of Aux to Foc and movement of the predicate phrase to SpecFoc. We also present the semantics of polarity focus, distinguishing several types of focus (informational, emphatic, contrastive.

  14. Kinetics of cesium lead halide perovskite nanoparticle growth; focusing and de-focusing of size distribution

    Science.gov (United States)

    Koolyk, Miriam; Amgar, Daniel; Aharon, Sigalit; Etgar, Lioz

    2016-03-01

    In this work we study the kinetics of cesium lead halide perovskite nanoparticle (NP) growth; the focusing and de-focusing of the NP size distribution. Cesium lead halide perovskite NPs are considered to be attractive materials for optoelectronic applications. Understanding the kinetics of the formation of these all-inorganic perovskite NPs is critical for reproducibly and reliably generating large amounts of uniformly sized NPs. Here we investigate different growth durations for CsPbI3 and CsPbBr3 NPs, tracking their growth by high-resolution transmission electron microscopy and size distribution analysis. As a result, we are able to provide a detailed model for the kinetics of their growth. It was observed that the CsPbI3 NPs exhibit focusing of the size distribution in the first 20 seconds of growth, followed by de-focusing over longer growth durations, while the CsPbBr3 NPs show de-focusing of the size distribution starting from the beginning of the growth. The monomer concentration is depleted faster in the case of CsPbBr3 than in the case of CsPbI3, due to faster diffusion of the monomers, which increases the critical radius and results in de-focusing of the population. Accordingly, focusing is not observed within 40 seconds of growth in the case of CsPbBr3. This study provides important knowledge on how to achieve a narrow size distribution of cesium lead halide perovskite NPs when generating large amounts of these promising, highly luminescent NPs.In this work we study the kinetics of cesium lead halide perovskite nanoparticle (NP) growth; the focusing and de-focusing of the NP size distribution. Cesium lead halide perovskite NPs are considered to be attractive materials for optoelectronic applications. Understanding the kinetics of the formation of these all-inorganic perovskite NPs is critical for reproducibly and reliably generating large amounts of uniformly sized NPs. Here we investigate different growth durations for CsPbI3 and CsPbBr3 NPs, tracking

  15. Magnetically focused liquid drop radiator

    Science.gov (United States)

    Botts, Thomas E.; Powell, James R.; Lenard, Roger

    1986-01-01

    A magnetically focused liquid drop radiator for application in rejecting rgy from a spacecraft, characterized by a magnetizable liquid or slurry disposed in operative relationship within the liquid droplet generator and its fluid delivery system, in combination with magnetic means disposed in operative relationship around a liquid droplet collector of the LDR. The magnetic means are effective to focus streams of droplets directed from the generator toward the collector, thereby to assure that essentially all of the droplets are directed into the collector, even though some of the streams may be misdirected as they leave the generator. The magnetic focusing means is also effective to suppress splashing of liquid when the droplets impinge on the collector.

  16. Finding beam focus errors automatically

    International Nuclear Information System (INIS)

    Lee, M.J.; Clearwater, S.H.; Kleban, S.D.

    1987-01-01

    An automated method for finding beam focus errors using an optimization program called COMFORT-PLUS. The steps involved in finding the correction factors using COMFORT-PLUS has been used to find the beam focus errors for two damping rings at the SLAC Linear Collider. The program is to be used as an off-line program to analyze actual measured data for any SLC system. A limitation on the application of this procedure is found to be that it depends on the magnitude of the machine errors. Another is that the program is not totally automated since the user must decide a priori where to look for errors

  17. Urbanization and Slum Formation

    Science.gov (United States)

    Phua, Kai Hong

    2007-01-01

    The formation of slums need not be inevitable with rapid urbanization. Such an argument appears to be contradicted by evidence of large slum populations in a large number of developing countries and particularly in rapidly urbanizing regions like Asia. The evidence discussed suggests that city authorities faced with rapid urban development lack the capacity to cope with the diverse demands for infrastructural provision to meet economic and social needs. Not only are strategic planning and intervention major issues in agenda to manage rapid urbanization, but city governments are not effectively linking the economic development trajectory to implications for urban growth and, hence, housing needs. In the following discussion, a case study is presented in support of the argument that city governments have to first recognize and then act to establish the link that is crucial between economic development, urban growth, and housing. This is the agendum that has been largely neglected by city and national governments that have been narrowly focused on economic growth with the consequent proliferation of slum formation as a housing solution. PMID:17387618

  18. Depletion field focusing in semiconductors

    NARCIS (Netherlands)

    Prins, M.W.J.; Gelder, Van A.P.

    1996-01-01

    We calculate the three-dimensional depletion field profile in a semiconductor, for a planar semiconductor material with a spatially varying potential upon the surface, and for a tip-shaped semiconductor with a constant surface potential. The nonuniform electric field gives rise to focusing or

  19. Instabilities in the plasma focus

    International Nuclear Information System (INIS)

    Kaeppeler, H.J.

    1975-03-01

    The plasma focus was studied by many research teams in view of a possible approach to controlled thermonuclear fusion. Though it is questionable whether the plasma focus will ever lead to a fusion reactor, it nevertheless constitutes a strong source of neutron, X- and gamma radiation for simulating fusion reactor conditions. Furthermore, the plasma focus yields very high temperatures (10 7 K) and densities (> 10 19 cm -3 ) and thus provides interesting conditions for the study of high density plasmas. This review paper starts with a description of the compression stage of the focussing plasma, using a snow-plough model. It is shown that sophisticated MHD calculations substantiate the snowplough theory, but are not suited to describe the phenomena in the final compressed stage. For this purpose, a particle-in-cell calculation is employed, yielding a beam-beam collision model for the neutron production. Experimental evidence indicates that neutron production is associated with the appearence of m = O instabilities and is the direct result of collisions between anomalously accelerated ions. One of the mechanisms of ion acceleration are strong local electric fields. Another possible mechanism can bee seen in beam-plasma instabilities caused by runaway electrons. The analytical derivation of the dispersion relation for plasma focus conditions including runaway effect is discussed (orig.) [de

  20. Focus group report, Part I

    International Nuclear Information System (INIS)

    1997-07-01

    The Waste Policy Institute, through a cooperative agreement with the U.S. Department of Energy's (DOE) Office of Science and Technology (OST), conducted two focus groups with people who live or work near DOE sites. The purpose of the focus groups was to gain a better understanding of the general community's information needs about the development of innovative technologies that are used in the cleanup of the sites. The authors wanted to better understand of what role these people want to play in the development of new technologies, how OST communication products can help facilitate that role, and the usefulness of current OST communication products. WPI held the focus groups in communities near the Idaho National Engineering and Environmental Laboratory (INEEL) and the Savannah River Site (SRS) because they are among the DOE sites that cannot be cleaned up before 2006. To include many facets of the communities, WPI randomly selected participants from membership lists of organized groups in each community including: elected officials, school boards, unions, chambers of commerce, economic development organizations, environmental organizations, health and human service organizations, and area clergy. While in the communities, WPI also interviewed stakeholders such as tribal representatives and a Citizens Advisory Board (CAB) member. Qualitative data gathered during the focus group sessions give some indication of general stakeholder opinions. However, the authors caution readers not to make broad assumptions about the general stakeholder audience based on the opinions of a limited number of general community stakeholders

  1. Technology for Education. IDRA Focus.

    Science.gov (United States)

    IDRA Newsletter, 1998

    1998-01-01

    This theme issue includes five articles that focus on technology for education to benefit all students, including limited-English-proficient, minority, economically disadvantaged, and at-risk students. "Coca-Cola Valued Youth Program Students Meet Peers Via Video Conference" (Linda Cantu, Leticia Lopez-De La Garza) describes how at-risk…

  2. Environmental Protection: a shifting focus

    NARCIS (Netherlands)

    Dr. ir. Jan Venselaar

    2004-01-01

    The last two decades have seen a fundamental change in the way chemistry handles environmental issues. A shift in focus has occurred from 'end-of-pipe' to prevention and process integration. Presently an even more fundamental change is brought about by the need for sustainable development. It is

  3. Focus groups in organizational research

    Directory of Open Access Journals (Sweden)

    L. Kamfer

    1989-05-01

    Full Text Available Focus groups are commonly used in marketing research. In this article an application of the focus group technique within an organizational context is described. Nine focus groups were conducted during the planning stage of a survey intended to establish employee perceptions of advancement policies and practices in a major South African manufacturing company. Fourteen themes emerged from a content analysis of the discussions. Two of these reflected aspects requiring commitment decisions from management toward the survey. The others indicated areas of concern which should be included in the survey. In this way, the focus groups contributed useful information for the subsequent sample survey. Opsomming Fokusgroepe word algemeen in bemarkingsnavorsing aangewend. In hierdie studie word 'n toepassingvan die fokusgroeptegniek in die konteks van 'n opname binne 'n organisasie beskryf. Nege fokusgroepbesprekings is gevoer tydens die beplanningstadium van 'n opname wat binne 'n Suid-Afrikaanse vervaardigingsonderneming gedoen is. Die doel van die opname was om die persepsies van werknemers teenoor die bestaande personeel- en bestuursontwikkelingsbeleid en -praktyke van die maatskappy te bepaal. Veertien temas is deur middel van 'n inhoudontleding gei'dentifiseer. Twee hiervan het aspekte aangedui waaroor bestuur beginselbesluite t.o.v. die opname sou moes neem. Die ander het probleemareas aangedui wat by die ondersoek selfingesluit behoort te word. Sodoende het die fokusgroepe inligting verskafwat vir die latere vraelysopname belangrik was.

  4. Verum focus and polar questions

    Directory of Open Access Journals (Sweden)

    Ion Giurgea

    2012-01-01

    Full Text Available We argue that some word order phenomena in Romanian and Sardinian are the result of a checkingoperation in the left periphery involving verum focus (i.e. focus on the polarity component of the sentence.In particular, this operation accounts for some word order patterns found in polar questions. In Romanian,polarity fronting is realized as head-movement of (V+T to a higher peripheral head which bears a Focusprobe.This licenses VS orders for predications in which VS is not allowed as a neutral order (i-levelpredicates, iteratives, generics. In Sardinian, an entire phrase headed by the lexical predicate (verbal nonfiniteform or non-verbal predicate is fronted before the auxiliary. We argue that this order is obtained bytwo movement operations, head-raising of Aux to Foc and movement of the predicate phrase to SpecFoc. Wealso present the semantics of polarity focus, distinguishing several types of focus (informational, emphatic,contrastive.

  5. Work and Family. Special Focus.

    Science.gov (United States)

    Goetz, Kathy, Ed.

    1992-01-01

    This newsletter issue focuses on issues concerning families with both parents employed outside the home and describes several employer programs designed to help employees balance their work and family life. The newsletter includes the following articles: (1) "Work and Family: 1992"; (2) "Levi Strauss and Co.--A Work/Family Program…

  6. FOREWORD: Focus on Advanced Ceramics Focus on Advanced Ceramics

    Science.gov (United States)

    Ohashi, Naoki

    2011-06-01

    Much research has been devoted recently to developing technologies for renewable energy and improving the efficiency of the processes and devices used in industry and everyday life. Efficient solutions have been found using novel materials such as platinum and palladium-based catalysts for car exhaust systems, samarium-cobalt and neodymium-iron-boron permanent magnets for electrical motors, and so on. However, their realization has resulted in an increasing demand for rare elements and in their deficit, the development of new materials based on more abundant elements and new functionalities of traditional materials. Moreover, increasing environmental and health concerns demand substitution of toxic or hazardous substances with nature-friendly alternatives. In this context, this focus issue on advanced ceramics aims to review current trends in ceramics science and technology. It is related to the International Conference on Science and Technology of Advanced Ceramics (STAC) held annually to discuss the emerging issues in the field of ceramics. An important direction of ceramic science is the collaboration between experimental and theoretical sciences. Recent developments in density functional theory and computer technology have enabled the prediction of physical and chemical properties of ceramics, thereby assisting the design of new materials. Therefore, this focus issue includes articles devoted to theory and advanced characterization techniques. As mentioned above, the potential shortage of rare elements is becoming critical to the industry and has resulted in a Japanese government initiative called the 'Ubiquitous Element Strategy'. This focus issue also includes articles related to this strategy and to the associated topics of energy conversion, such as phosphors for high-efficiency lighting and photocatalysts for solar-energy harvesting. We hope that this focus issue will provide a timely overview of current trends and problems in ceramics science and

  7. An ultra miniature pinch-focus discharge

    International Nuclear Information System (INIS)

    Soto, L.; Pavez, C.; Moreno, J.; Pavez, C.; Barbaglia, M.; Clausse, A.

    2004-01-01

    As a way to investigate the minimum energy to produce a pinch plasma focus discharge, an ultra miniature device has been designed and constructed (nano focus NF: 5 nF, 5-10 kV, 5-10 kA, 60-250 mJ, 16 ns time to peak current). Sub-millimetric anode radius covered by a coaxial insulator were used for experiments in hydrogen. Evidence of pinch was observed in electrical signals in discharges operating at 60 mJ. A single-frame image converter camera (4 ns exposure) was used to obtain plasma images in the visible range. The dynamics observed from the photographs is consistent with: a) formation of a plasma sheath close to the insulator surface, b) fast axial motion of the plasma sheath, c) radial compression over the anode, and d) finally the plasma is detached from the anode in the axial direction. The total time since stage a) to d) was observed to be about 30 ns. X ray and neutron emission is being studied. Neutron yield of the order of 10 3 neutrons per shot is expected for discharges operating in deuterium at 10 kA. (authors)

  8. Plasma focusing in coaxial gun

    International Nuclear Information System (INIS)

    Soliman, H.M.; Masoud, M.M.; El-Khalafawy, T.

    1986-01-01

    A capacitor bank has been discharged between two coaxial electrodes of 6.6 cm outer diameter, 3.2 cm inner diameter and length of 31.5 cm. filled with hydrogen gas at pressure of 310 μHg. Results show that, the axial and radial plasma current reach a maximum value at a position adjacent to the gun muzzle, at which the plasma focus occurs. The measurement of the electron temperature and density and azimuthal electric field along the axis of the expansion chamber, gives a maximum value at z∼18 cm from the gun muzzle, while the axial plasma current and velocity has a minimum value at that position. These results indicate that a second point of a plasma focus has been formed at z∼18 cm from the gun muzzle, along the axis of the expansion chamber

  9. Focusing Telescopes in Nuclear Astrophysics

    CERN Document Server

    Ballmoos, Peter von

    2007-01-01

    This volume is the first of its kind on focusing gamma-ray telescopes. Forty-eight refereed papers provide a comprehensive overview of the scientific potential and technical challenges of this nascent tool for nuclear astrophysics. The book features articles dealing with pivotal technologies such as grazing incident mirrors, multilayer coatings, Laue- and Fresnel-lenses - and even an optic using the curvature of space-time. The volume also presents an overview of detectors matching the ambitious objectives of gamma ray optics, and facilities for operating such systems on the ground and in space. The extraordinary scientific potential of focusing gamma-ray telescopes for the study of the most powerful sources and the most violent events in the Universe is emphasized in a series of introductory articles. Practicing professionals, and students interested in experimental high-energy astrophysics, will find this book a useful reference

  10. Reflectors to Focus Wave Energy

    DEFF Research Database (Denmark)

    Kramer, Morten; Frigaard, Peter

    2005-01-01

    Wave Energy Converters (WEC’s) extract wave energy from a limited area, often a single point or line even though the wave energy is generally spread out along the wave crest. By the use of wave reflectors (reflecting walls) the wave energy is effectively focused and increased by approximately 30......-50%. Clearly longer wave reflectors will focus more wave energy than shorter wave reflectors. Thus the draw back is the increased wave forces for the longer wave reflectors. In the paper a procedure for calculating the energy efficiency and the wave forces on the reflectors are described, this by use of a 3D...... boundary element method. The calculations are verified by laboratory experiments and a very good agreement is found. The paper gives estimates of possible power benefit for different wave reflector geometries and optimal geometrical design parameters are specified. On this basis inventors of WEC’s can...

  11. Ion beam generation and focusing

    International Nuclear Information System (INIS)

    Miller, P.A.; Mendel, C.W.; Swain, D.W.; Goldstein, S.A.

    1975-01-01

    Calculations have shown that efficiently generated and focused ion beams could have significant advantages over electron beams in achieving ignition of inertially-confined thermonuclear fuel. Efficient ion beam generation implies use of a good ion source and suppression of net electron current. Net electron flow can be reduced by allowing electrons to reflex through a highly transparent anode or by use of transverse magnetic fields (either beam self-fields or externally applied fields). Geometric focusing can be achieved if the beam is generated by appropriately shaped electrodes. Experimental results are presented which demonstrate ion beam generation in both reflexing and pinched-flow diodes. Spherically shaped electrodes are used to concentrate a proton beam, and target response to proton deposition is studied

  12. Plasma-focused cyclic accelerators

    International Nuclear Information System (INIS)

    Mondelli, A.A.; Chernin, D.P.

    1985-01-01

    The use of ambient plasma to neutralize the transverse forces of an intense particle beam has been known for many years. Most recently, the so-called ion-focused regime (IFR) for beam propagation has been used as a means of focusing intense electron beams in linear accelerators and suggested for injecting an electron beam across magnetic field lines into a high-current cyclic accelerator. One technique for generating the required background plasma for IFR propagation is to use a laser to ionize ambient gas in the accelerator chamber. This paper discusses an alternative means of plasma production for IFR, viz. by using RF breakdown. For this approach the accelerator chamber acts as a waveguide. This technique is not limited to toroidal accelerators. It may be applied to any accelerator or recirculator geometry as well as for beam steering and for injection or extraction of beams in closed accelerator configurations

  13. Optimum Design of Plasma Focus

    International Nuclear Information System (INIS)

    Ramos, Ruben; Gonzalez, Jose; Clausse, Alejandro

    2000-01-01

    The optimum design of Plasma Focus devices is presented based in a lumped parameter model of the MHD equations.Maps in the design parameters space are obtained, which determine the length and deuterium pressure required to produce a given neutron yield.Sensitivity analyses of the main effective numbers (sweeping efficiencies) was performed, and lately the optimum values were determined in order to set a basis for the conceptual design

  14. Focus On Photoshop Elements Focus on the Fundamentals

    CERN Document Server

    Asch, David

    2011-01-01

    Are you bewildered by the advanced editing options available in Photoshop Elements? Do you want to get the most out of your image without going bleary-eyed in front of a computer screen? This handy guide will explain the ins and outs of using Photoshop Elements, without having to spend hours staring at the screen. Using a fabulous combination of easy-to-follow advice and step-by-step instructions, Focus On Photoshop Elements gives great advice on setting up, storing and sharing your image library and teaches you the basics of RAW image processing and color correction, plus shows you how to edi

  15. GRI: focusing on the evolving violent universe

    Science.gov (United States)

    Knödlseder, Jürgen; von Ballmoos, Peter; Frontera, Filippo; Bazzano, Angela; Christensen, Finn; Hernanz, Margarida; Wunderer, Cornelia

    2009-03-01

    The gamma-ray imager (GRI) is a novel mission concept that will provide an unprecedented sensitivity leap in the soft gamma-ray domain by using for the first time a focusing lens built of Laue diffracting crystals. The lens will cover an energy band from 200-1,300 keV with an effective area reaching 600 cm2. It will be complemented by a single reflection multilayer coated mirror, extending the GRI energy band into the hard X-ray regime, down to ˜10 keV. The concentrated photons will be collected by a position sensitive pixelised CZT stack detector. We estimate continuum sensitivities of better than 10 - 7 ph cm - 2s - 1keV - 1 for a 100 ks exposure; the narrow line sensitivity will be better than 3 × 10 - 6 ph cm - 2s - 1 for the same integration time. As focusing instrument, GRI will have an angular resolution of better than 30 arcsec within a field of view of roughly 5 arcmin—an unprecedented achievement in the gamma-ray domain. Owing to the large focal length of 100 m of the lens and the mirror, the optics and detector will be placed on two separate spacecrafts flying in formation in a high elliptical orbit. R&D work to enable the lens focusing technology and to develop the required focal plane detector is currently underway, financed by ASI, CNES, ESA, and the Spanish Ministery of Education and Science. The GRI mission has been proposed as class M mission for ESAs Cosmic Vision 2015-2025 program. GRI will allow studies of particle acceleration processes and explosion physics in unprecedented detail, providing essential clues on the innermost nature of the most violent and most energetic processes in the universe.

  16. Focusing of Shear Shock Waves

    Science.gov (United States)

    Giammarinaro, Bruno; Espíndola, David; Coulouvrat, François; Pinton, Gianmarco

    2018-01-01

    Focusing is a ubiquitous way to transform waves. Recently, a new type of shock wave has been observed experimentally with high-frame-rate ultrasound: shear shock waves in soft solids. These strongly nonlinear waves are characterized by a high Mach number, because the shear wave velocity is much slower, by 3 orders of magnitude, than the longitudinal wave velocity. Furthermore, these waves have a unique cubic nonlinearity which generates only odd harmonics. Unlike longitudinal waves for which only compressional shocks are possible, shear waves exhibit cubic nonlinearities which can generate positive and negative shocks. Here we present the experimental observation of shear shock wave focusing, generated by the vertical motion of a solid cylinder section embedded in a soft gelatin-graphite phantom to induce linearly vertically polarized motion. Raw ultrasound data from high-frame-rate (7692 images per second) acquisitions in combination with algorithms that are tuned to detect small displacements (approximately 1 μ m ) are used to generate quantitative movies of gel motion. The features of shear shock wave focusing are analyzed by comparing experimental observations with numerical simulations of a retarded-time elastodynamic equation with cubic nonlinearities and empirical attenuation laws for soft solids.

  17. High efficiency focus neutron generator

    Science.gov (United States)

    Sadeghi, H.; Amrollahi, R.; Zare, M.; Fazelpour, S.

    2017-12-01

    In the present paper, the new idea to increase the neutron yield of plasma focus devices is investigated and the results are presented. Based on many studies, more than 90% of neutrons in plasma focus devices were produced by beam target interactions and only 10% of them were due to thermonuclear reactions. While propounding the new idea, the number of collisions between deuteron ions and deuterium gas atoms were increased remarkably well. The COMSOL Multiphysics 5.2 was used to study the given idea in the known 28 plasma focus devices. In this circumstance, the neutron yield of this system was also obtained and reported. Finally, it was found that in the ENEA device with 1 Hz working frequency, 1.1 × 109 and 1.1 × 1011 neutrons per second were produced by D-D and D-T reactions, respectively. In addition, in the NX2 device with 16 Hz working frequency, 1.34 × 1010 and 1.34 × 1012 neutrons per second were produced by D-D and D-T reactions, respectively. The results show that with regards to the sizes and energy of these devices, they can be used as the efficient neutron generators.

  18. Focus group report - part II

    International Nuclear Information System (INIS)

    1997-12-01

    The Waste Policy Institute, through a cooperative agreement with the U.S. Department of Energy (DOE) Office of Science and Technology (OST) conducted a focus group with members of the Hanford Advisory Board (HAB), interviews with tribal government representatives, and a survey of Oak Ridge Local Oversight Committee (LOC) and Site Specific Advisory Board (SSAB) members. The purpose was to understand what members of the interested and involved public want to know about technology development and ways to get that information to them. These data collection activities were used as a follow-up to two previously held focus groups with the general public near Idaho National Engineering and Environmental Laboratory (INEEL) and the Savannah River Site (SRS). Most participants from the first two focus groups said they did not have time and/or were not interested in participating in technology decision-making. They said they would prefer to defer to members of their communities who are interested and want to be involved in technology decision-making

  19. Issues in the Analysis of Focus Groups: Generalisability, Quantifiability, Treatment of Context and Quotations

    Science.gov (United States)

    Vicsek, Lilla

    2010-01-01

    In this paper I discuss some concerns related to the analysis of focus groups: (a) the issue of generalisation; (b) the problems of using numbers and quantifying in the analysis; (c) how the concrete situation of the focus groups could be included in the analysis, and (d) what formats can be used when quoting from focus groups. Problems with…

  20. The quest for customer focus.

    Science.gov (United States)

    Gulati, Ranjay; Oldroyd, James B

    2005-04-01

    Companies have poured enormous amounts of money into customer relationship management, but in many cases the investment hasn't really paid off. That's because getting closer to customers isn't about building an information technology system. It's a learning journey-one that unfolds over four stages, requiring people and business units to coordinate in progressively more sophisticated ways. The journey begins with the creation of a companywide repository containing each interaction a customer has with the company, organized not by product, purchase, or location, but by customer. Communal coordination is what's called for at this stage, as each group contributes its information to the data pool separately from the others and then taps into it as needed. In the second stage, one-way serial coordination from centralized IT through analytical units and out to the operating units allows companies to go beyond just assembling data to drawing inferences. In stage three, companies shift their focus from past relationships to future behavior. Through symbiotic coordination, information flows back and forth between central analytic units and various organizational units like marketing, sales, and operations, as together they seek answers to questions like "How can we prevent customers from switching to a competitor?" and "Who would be most likely to buy a new product in the future"? In stage four, firms begin to move past discrete, formal initiatives and, through integral coordination, bring an increasingly sophisticated understanding oftheir customers to bear in all day-to-day operations. Skipping stages denies organizations the sure foundation they need to build a lasting customer-focused mind-set. Those that recognize this will invest their customer relationship dollars much more wisely-and will see their customer-focusing efforts pay offon the bottom line.

  1. A focused bibliography on robotics

    Science.gov (United States)

    Mergler, H. W.

    1983-08-01

    The present bibliography focuses on eight robotics-related topics believed by the author to be of special interest to researchers in the field of industrial electronics: robots, sensors, kinematics, dynamics, control systems, actuators, vision, economics, and robot applications. This literature search was conducted through the 1970-present COMPENDEX data base, which provides world-wide coverage of nearly 3500 journals, conference proceedings and reports, and the 1969-1981 INSPEC data base, which is the largest for the English language in the fields of physics, electrotechnology, computers, and control.

  2. Focus on topological quantum computation

    International Nuclear Information System (INIS)

    Pachos, Jiannis K; Simon, Steven H

    2014-01-01

    Topological quantum computation started as a niche area of research aimed at employing particles with exotic statistics, called anyons, for performing quantum computation. Soon it evolved to include a wide variety of disciplines. Advances in the understanding of anyon properties inspired new quantum algorithms and helped in the characterization of topological phases of matter and their experimental realization. The conceptual appeal of topological systems as well as their promise for building fault-tolerant quantum technologies fuelled the fascination in this field. This ‘focus on’ collection brings together several of the latest developments in the field and facilitates the synergy between different approaches. (editorial)

  3. Focus on astronomical predictable events

    DEFF Research Database (Denmark)

    Jacobsen, Aase Roland

    2006-01-01

    At the Steno Museum Planetarium we have for many occasions used a countdown clock to get focus om astronomical events. A countdown clock can provide actuality to predictable events, for example The Venus Transit, Opportunity landing on Mars and The Solar Eclipse. The movement of the clock attracs...... the public and makes a point of interest in a small exhibit area. A countdown clock can be simple, but it is possible to expand the concept to an eye-catching part of a museum....

  4. Catastrophe in plasma focus evolution

    International Nuclear Information System (INIS)

    Ikuta, Kazunari.

    1984-07-01

    A theory of generating strong electric field in a dense plasma column in plasma focus is established by applying the formula for the electron thermal conductivity in destroyed magnetic surfaces like those in tokamaks. The origin of the electric field may be from abrupt rise of plasma resistivity when the irregularity of magnetic field is weak. However, the electric field can be from the inductive origin in case the irregularity attains a certain level. Both origin should be mixed up depending on the magnitude of the irregularity. (author)

  5. Final focus system for TLC

    International Nuclear Information System (INIS)

    Oide, K.

    1988-11-01

    A limit of the chromaticity correction for the final focus system of a TeV Linear Collider (TLC) is investigated. As the result, it becomes possible to increase the aperture of the final doublet with a small increase of the horizontal β function. The new optics design uses a final doublet of 0.5 mm half-aperture and 1.4 T pole-tip field. The length of the system is reduced from 400 m to 200 m by several optics changes. Tolerances for various machine errors with this optics are also studied. 5 refs., 7 figs., 2 tabs

  6. Review of nutrition labeling formats.

    Science.gov (United States)

    Geiger, C J; Wyse, B W; Parent, C R; Hansen, R G

    1991-07-01

    This article examines nutrition labeling history as well as the findings of nine research studies of nutrition labeling formats. Nutrition labeling regulations were announced in 1973 and have been periodically amended since then. In response to requests from consumers and health care professionals for revision of the labeling system, the Food and Drug Administration initiated a three-phase plan for reform of nutrition labeling in 1990. President Bush signed the Nutrition Labeling and Education Act in November 1990. Literature analysis revealed that only nine studies with an experimental design have focused on nutrition labeling since 1971. Four were conducted before 1975, which was the year that nutrition labeling was officially implemented, two were conducted in 1980, and three were conducted after 1986. Only two of the nine studies supported the traditional label format mandated by the Code of Federal Regulations, and one study partially supported it. Four of the nine studies that evaluated graphic presentations of nutrition information found that consumer comprehension of nutrition information was improved with a graphic format for nutrition labeling: three studies supported the use of bar graphs and one study supported the use of a pie chart. Full disclosure (ie, complete nutrient and ingredient labeling) was preferred by consumers in two of the three studies that examined this variable. The third study supported three types of information disclosure dependent upon socioeconomic class. In those studies that tested graphics, a bar graph format was significantly preferred and showed better consumer comprehension than the traditional format.

  7. Rates of star formation

    International Nuclear Information System (INIS)

    Larson, R.B.

    1977-01-01

    It is illustrated that a theoretical understanding of the formation and evolution of galaxies depends on an understanding of star formation, and especially of the factors influencing the rate of star formation. Some of the theoretical problems of star formation in galaxies, some approaches that have been considered in models of galaxy evolution, and some possible observational tests that may help to clarify which processes or models are most relevant are reviewed. The material is presented under the following headings: power-law models for star formation, star formation processes (conditions required, ways of achieving these conditions), observational indications and tests, and measures of star formation rates in galaxies. 49 references

  8. Why adult formation

    Directory of Open Access Journals (Sweden)

    Andrej Justinek

    1997-01-01

    Full Text Available The article argues that the primary aim of adult formation is comprehensive personality development which is supposed to ensure quality existence in modern world. The article also suggests that formarion is a permanent process. Justinek puts special emphasis on adult formation methodology and defines fundamental formation styles which encourage independent action in individuals. Justinek differentiates between formation and education. methods and concludes that formation methods are related to the emotional sphere of personality, and education methods mostly to the rational. Justinek believes that formation of adults is based primarily on appropriate formation methodology.

  9. Focus on the Rashba effect

    Science.gov (United States)

    Bihlmayer, G.; Rader, O.; Winkler, R.

    2015-05-01

    The Rashba effect, discovered in 1959, continues to supply fertile ground for fundamental research and applications. It provided the basis for the proposal of the spin transistor by Datta and Das in 1990, which has largely inspired the broad and dynamic field of spintronics. More recent developments include new materials for the Rashba effect such as metal surfaces, interfaces and bulk materials. It has also given rise to new phenomena such as spin currents and the spin Hall effect, including its quantized version, which has led to the very active field of topological insulators. The Rashba effect plays a crucial role in yet more exotic fields of physics such as the search for Majorana fermions at semiconductor-superconductor interfaces and the interaction of ultracold atomic Bose and Fermi gases. Advances in our understanding of Rashba-type spin-orbit couplings, both qualitatively and quantitatively, can be obtained in many different ways. This focus issue brings together the wide range of research activities on Rashba physics to further promote the development of our physical pictures and concepts in this field. The present Editorial gives a brief account on the history of the Rashba effect including material that was previously not easily accessible before summarizing the key results of the present focus issue as a guidance to the reader.

  10. Plasma-focused cyclic accelerators

    International Nuclear Information System (INIS)

    Mondelli, A.A.; Chernin, D.P.

    1985-01-01

    The use of ambient plasma to neutralize the transverse forces of an intense particle beam has been known for many years. Most recently, the so-called ion-focused regime (IFR) for beam propagation has been used as a means of focusing intense electron beams in linear accelerators and suggested for injecting an electron beam across magnetic field lines into a high-current cyclic accelerator. One technique for generating the required background plasma for IFR propagation is to use a laser to ionize ambient gas in the accelerator chamber. For cyclic accelerators a technique is required for carrying the plasma channel and the beam around a bend. Multiple laser-generated channels with dipole magnetic fields to switch the beam from one channel to the next have been tested at Sandia. This paper discusses an alternative means of plasma production for IFR, viz. by using rf breakdown. For this approach the accelerator chamber acts as a waveguide. With a suitable driving frequency, a waveguide mode can be driven which has its peak field intensity on the axis with negligible fields at the chamber walls. The plasma production and hence the beam propagation is thereby isolated from the walls. This technique is not limited to toroidal accelerators. It may be applied to any accelerator or recirculator geometry as well as for beam steering and for injection or extraction of beams in closed accelerator configurations

  11. Reflections about the mathematics teachers' formation

    Directory of Open Access Journals (Sweden)

    Maria José de Freitas Mendes

    2010-06-01

    Full Text Available This paper brings some reflections about the formation of the math teacher that made part of my marsters paper and that aimed to investigate the process of formation of the math teacher. The focus of this study incided at the contributions of teaching practice in the teacher's formation above the new paradigms of formation, as a professional development and as a reflexive teacher. These reflections, from the learning and teaching process and from the meaning of form a teacher analyse the crisis and the restructuration of the teacher's formation and conclude being necessary that in the graduation courses there's a character more practice to the pedagogical formation, making possible for the future teacher to develop attitudes of autonomy, reflexion and investigation

  12. Synchrotron radiation focusing by a Bragg--Fresnel lens

    International Nuclear Information System (INIS)

    Aristov, V.V.; Basov, Y.A.; Snigirev, A.A.

    1989-01-01

    Since the discovery of x rays and until the present time the possibilities of their controlling and focusing have been widely discussed. In the hard spectrum region (λ∼1 A) the main focusing schemes are the following: geometrical focusing based on incoherent interaction of wave packets reflected by different regions of bending crystals and coherent (dynamic) focusing performed at the cost of the effect of refraction index angular dispersion near the exact Bragg angle value -θ B . A main disadvantage of geometrical focusing is low spatial resolution (∼0.1 mm) and temperature stability. In the case of coherent focusing a main disadvantage is a narrow angular aperture (∼10 sec. of arc) at spatial resolution (∼1--10 μm). Recently, advances in the development of diffraction physics and microstructuring technology open up possibilities for fabricating effective focusing x-ray optical elements---Bragg--Fresnel lenses (BFL)---with high spatial resolution (∼0.1 μm) at a wide angular aperture and high temperature stability. The present paper describes the main principles of Bragg--Fresnel optics (BFO). It presents the results on the synchrotron experiment and on observation of focusing. In this work the peculiarities of BFL diffraction contrast formation are investigated and image transmission using a BFL is performed. Possibilities of developing x-ray optical schemes of ultrahigh resolution on the basis of BFL elements are also discussed

  13. Focusing telescopes in nuclear astrophysics

    International Nuclear Information System (INIS)

    Von Ballmoos, P.; Knodlseder, R.; Sazonov, S.; Griffiths, R.; Bastie, P.; Halloin, H.; Pareschi, G.; Ramsey, B.; Jensen, C.; Buis, E.J.; Ulmer, M.; Giommi, P.; Colafrancesco, S.; Comastri, A.; Barret, D.; Leising, M.; Hernanz, M.; Smith, D.; Abrosimov, N.; Smither, B.; Ubertini, P.; Olive, J.F.; Lund, N.; Pisa, A.; Courtois, P.; Roa, D.; Harrison, F.; Pareschi, G.; Frontera, F.; Von Ballmoos, P.; Barriere, N.; Rando, N.; Borde, J.; Hinglais, E.; Cledassou, R.; Duchon, P.; Sghedoni, M.; Huet, B.; Takahashi, T.; Caroli, E.; Quadrinin, L.; Buis, E.J.; Skinner, G.; Krizmanic, J.; Pareschi, G.; Loffredo, G.; Wunderer, C.; Weidenspointner, G.; Wunderer, C.; Koechlin, L.; Bignami, G.; Von Ballmoos, P.; Tueller, J.; Andritschke, T.; Laurens, A.; Evrard, J.

    2005-01-01

    The objective of this workshop is to consider the next generation of instrumentation to be required within the domain of nuclear astrophysics. A small, but growing community has been pursuing various techniques for the focusing of hard X-rays and gamma-rays with the aim of achieving a factor of up to 100 improvement in sensitivity over present technologies. Balloon flight tests of both multilayer mirrors and a Laue lens have been performed and ideas abound. At present, implementation scenarios for space missions are being studied at Esa, CNES, and elsewhere. The workshop will provide a first opportunity for this new community to meet, exchange technological know-how, discuss scientific objectives and synergies, and consolidate implementation approaches within National and European Space Science programs. This document gathers the slides of all the presentations

  14. Focus on integrated quantum optics

    International Nuclear Information System (INIS)

    O'Brien, Jeremy; Patton, Brian; Sasaki, Masahide; Vučković, Jelena

    2013-01-01

    A key goal of research into quantum information processing is the development of technologies that are scaleable in complexity while allowing the mass manufacture of devices that promise transformative effects on information science. The demonstration that integrated photonics circuits could be made to perform operations that exploit the quantum nature of the photon has turned them into leading candidates for practical quantum information processing technologies. To fully achieve their promise, however, requires research from diverse fields. This focus issue provides a snapshot of some of the areas in which key advances have been made. We are grateful for the contributions from leading teams based around the globe and hope that the degree of progress being made in a challenging and exciting field is apparent from the papers published here. (editorial)

  15. Focusing telescopes in nuclear astrophysics

    Energy Technology Data Exchange (ETDEWEB)

    Von Ballmoos, P; Knodlseder, R; Sazonov, S; Griffiths, R; Bastie, P; Halloin, H; Pareschi, G; Ramsey, B; Jensen, C; Buis, E J; Ulmer, M; Giommi, P; Colafrancesco, S; Comastri, A; Barret, D; Leising, M; Hernanz, M; Smith, D; Abrosimov, N; Smither, B; Ubertini, P; Olive, J F; Lund, N; Pisa, A; Courtois, P; Roa, D; Harrison, F; Pareschi, G; Frontera, F; Von Ballmoos, P; Barriere, N; Rando, N; Borde, J; Hinglais, E; Cledassou, R; Duchon, P; Sghedoni, M; Huet, B; Takahashi, T; Caroli, E; Quadrinin, L; Buis, E J; Skinner, G; Krizmanic, J; Pareschi, G; Loffredo, G; Wunderer, C; Weidenspointner, G; Wunderer, C; Koechlin, L; Bignami, G; Von Ballmoos, P; Tueller, J; Andritschke, T; Laurens, A; Evrard, J

    2005-07-01

    The objective of this workshop is to consider the next generation of instrumentation to be required within the domain of nuclear astrophysics. A small, but growing community has been pursuing various techniques for the focusing of hard X-rays and gamma-rays with the aim of achieving a factor of up to 100 improvement in sensitivity over present technologies. Balloon flight tests of both multilayer mirrors and a Laue lens have been performed and ideas abound. At present, implementation scenarios for space missions are being studied at Esa, CNES, and elsewhere. The workshop will provide a first opportunity for this new community to meet, exchange technological know-how, discuss scientific objectives and synergies, and consolidate implementation approaches within National and European Space Science programs. This document gathers the slides of all the presentations.

  16. Tank Focus Area pretreatment activities

    International Nuclear Information System (INIS)

    McGinnis, C.P.; Welch, T.D.; Manke, K.L.

    1997-01-01

    Plans call for the high-level wastes to be retrieved from the tanks and immobilized in a stable waste form suitable for long-term isolation. Chemistry and chemical engineering operations are required to retrieve the wastes, to condition the wastes for subsequent steps, and to reduce the costs of the waste management enterprise. Pretreatment includes those processes between retrieval and immobilization, and includes preparation of suitable feed material for immobilization and separations to partition the waste into streams that yield lower life-cycle costs. Some of the technologies being developed by the Tank Focus Area (TFA) to process these wastes are described. These technologies fall roughly into three areas: (1) solid/liquid separation (SLS), (2) sludge pretreatment, and (3) supernate pretreatment

  17. Focus: Asian migration to Canada.

    Science.gov (United States)

    Kobayashi, A

    1988-01-01

    This collection of 5 short essays on Asian migration to Canada focuses on the relationships between individual migrants and their social contexts, both Asian and Canadian. Papers by Anderson and Kobayashi adopt research perspectives of outsider and insider, respectively. Vibert provides a historical overview against which the substantive issues introduced in the other 3 papers can be understood, and he illustrates the links between circumstances of migration and the larger issues by which the course of Canadian social progress has been steered. Mercer provides an introduction to issues that dominate the agenda of contemporary research, to show that Canadian communities of Asian heritage continue to grow in size, diversity, and complexity, as they become more established on the Canadian landscape. This collection is as much about the geography of racism as it is about migration.

  18. Ionization waves of arbitrary velocity driven by a flying focus

    Science.gov (United States)

    Palastro, J. P.; Turnbull, D.; Bahk, S.-W.; Follett, R. K.; Shaw, J. L.; Haberberger, D.; Bromage, J.; Froula, D. H.

    2018-03-01

    A chirped laser pulse focused by a chromatic lens exhibits a dynamic, or flying, focus in which the trajectory of the peak intensity decouples from the group velocity. In a medium, the flying focus can trigger an ionization front that follows this trajectory. By adjusting the chirp, the ionization front can be made to travel at an arbitrary velocity along the optical axis. We present analytical calculations and simulations describing the propagation of the flying focus pulse, the self-similar form of its intensity profile, and ionization wave formation. The ability to control the speed of the ionization wave and, in conjunction, mitigate plasma refraction has the potential to advance several laser-based applications, including Raman amplification, photon acceleration, high-order-harmonic generation, and THz generation.

  19. SU-8 micropatterning for microfluidic droplet and microparticle focusing

    International Nuclear Information System (INIS)

    Debuisson, Damien; Senez, Vincent; Arscott, Steve

    2011-01-01

    We demonstrate micropatterned surfaces consisting of concentric circles and spirals which can focus an evaporating sessile droplet to a specific location on a surface. We also study the micropattern geometry to focus microparticles contained within the droplet. The micropatterned surfaces are fabricated using the photoresist SU-8. Our process enables the modification of the surface wetting via the formation of smooth trench-like defects in the SU-8 which define the micropatterns; the geometry of these micropatterns determines the droplet/microparticle focusing. It is clearly shown that the introduction of small gaps into the micropatterns promotes microparticle centring due to the modification of the depinning angle of the droplet. We also show that the use of spiral micropatterns promotes microparticle centring. Finally, microparticle focusing can be enhanced by modification of surface wetting via the addition of a thin fluorocarbon hydrophobic layer onto the SU-8

  20. Focus on quantum Einstein gravity Focus on quantum Einstein gravity

    Science.gov (United States)

    Ambjorn, Jan; Reuter, Martin; Saueressig, Frank

    2012-09-01

    The gravitational asymptotic safety program summarizes the attempts to construct a consistent and predictive quantum theory of gravity within Wilson's generalized framework of renormalization. Its key ingredient is a non-Gaussian fixed point of the renormalization group flow which controls the behavior of the theory at trans-Planckian energies and renders gravity safe from unphysical divergences. Provided that the fixed point comes with a finite number of ultraviolet-attractive (relevant) directions, this construction gives rise to a consistent quantum field theory which is as predictive as an ordinary, perturbatively renormalizable one. This opens up the exciting possibility of establishing quantum Einstein gravity as a fundamental theory of gravity, without introducing supersymmetry or extra dimensions, and solely based on quantization techniques that are known to work well for the other fundamental forces of nature. While the idea of gravity being asymptotically safe was proposed by Steven Weinberg more than 30 years ago [1], the technical tools for investigating this scenario only emerged during the last decade. Here a key role is played by the exact functional renormalization group equation for gravity, which allows the construction of non-perturbative approximate solutions for the RG-flow of the gravitational couplings. Most remarkably, all solutions constructed to date exhibit a suitable non-Gaussian fixed point, lending strong support to the asymptotic safety conjecture. Moreover, the functional renormalization group also provides indications that the central idea of a non-Gaussian fixed point providing a safe ultraviolet completion also carries over to more realistic scenarios where gravity is coupled to a suitable matter sector like the standard model. These theoretical successes also triggered a wealth of studies focusing on the consequences of asymptotic safety in a wide range of phenomenological applications covering the physics of black holes, early

  1. Patient satisfaction: focusing on "excellent".

    Science.gov (United States)

    Otani, Koichiro; Waterman, Brian; Faulkner, Kelly M; Boslaugh, Sarah; Burroughs, Thomas E; Dunagan, W Claiborne

    2009-01-01

    In an emerging competitive market such as healthcare, managers should focus on achieving excellent ratings to distinguish their organization from others. When it comes to customer loyalty, "excellent" has a different meaning. Customers who are merely satisfied often do not come back. The purpose of this study was to find out what influences adult patients to rate their overall experience as "excellent." The study used patient satisfaction data collected from one major academic hospital and four community hospitals. After conducting a multiple logistic regression analysis, certain attributes were shown to be more likely than others to influence patients to rate their experiences as excellent. The study revealed that staff care is the most influential attribute, followed by nursing care. These two attributes are distinctively stronger drivers of overall satisfaction than are the other attributes studied (i.e., physician care, admission process, room, and food). Staff care and nursing care are under the control of healthcare managers. If improvements are needed, they can be accomplished through training programs such as total quality management or continuous quality improvement, through which staff employees and nurses learn to be sensitive to patients' needs. Satisfying patients' needs is the first step toward having loyal patients, so hospitals that strive to ensure their patients are completely satisfied are more likely to prosper.

  2. Magnetic tearing in plasma focus

    International Nuclear Information System (INIS)

    Sharkawy, W.

    1994-01-01

    A plasma focus device used is Mather type filled with hydrogen gas at pressure between 0.1 and 1 torr. When connected to a large capacitor ≤10 KV a discharge is started with peak current 100 KA. Under the influence of the radial electric field E r , due to the potential between electrodes, and B φ the plasma will drift in the axial direction with velocity cE r /B φ . An induced axial magnetic field B z has been detected which due to sheath velocity. A propagation of magnetosonic wave has been observed with velocity ≅10 3 m sec -1 . Such a wave might be excited when the magnetic pressure is much greater than the plasma kinetic pressure B 2 /8π>nKT. Assuming (MHD) to be stable, Tearing model was driven which generally has smaller growth rates than (MHD) modes. Using the designed theoretical model and the plasma parameters the electron energy dΦ/dt=Ba 2 /τ R was calculated to be 2.22 KeV, which is comparable with that detected from X-ray measurements. (author)

  3. Focus issue introduction: nonlinear photonics.

    Science.gov (United States)

    Akhmediev, Nail; Rottwitt, Karsten

    2012-11-19

    It is now 23 years since the first Topical Meeting "Nonlinear Guided Wave Phenomena" (Houston, TX, February 2-4, 1989) has been organised by George Stegeman and Allan Boardman with support of the Optical Society of America. These series of the OSA conferences known as NLGW, continued under the name "Nonlinear Photonics" starting from 2007. The latest one, in Colorado Springs in June 17-21, 2012 has been a great success despite the fierce fires advancing around the city at the time of the conference. This Focus issue is a collection of several papers presented at the conference with extended content submitted to Optics Express. Although this collection is small in comparison to the total number of papers presented at the conference, it gives a flavor of the topics considered at the meeting. It is also worthy to mention here that the next meeting "Nonlinear Photonics" is planned to be held in Barcelona - one of the main European centers on this subject.

  4. Findings: LANL outsourcing focus groups

    Energy Technology Data Exchange (ETDEWEB)

    Jannotta, M.J.; McCabe, V.B.

    1996-12-31

    In March 1996, a series of 24 3-hour dialog focus groups were held with randomly selected Laboratory employees and contractors to gain their perceptions regarding potentials and problems for privatization and consolidation. A secondary goal was to educate and inform the workforce about potentials and issues in privatization and consolidation. Two hundred and thirty-six participants engaged in a learning session and structured input exercises resulting in 2,768 usable comments. Comments were categorized using standard qualitative methods; resulting categories included positive and negative comments on four models (consolidation, spin offs, outsourcing, and corporate partnering) and implications for the workforce, the Laboratory, and the local economy. Categories were in the areas of increasing/decreasing jobs, expertise, opportunity/salary/benefits, quality/efficiency, and effect on the local area and economy. An additional concern was losing Laboratory culture and history. Data were gathered and categorized on employee opinion regarding elements of successful transition to the four models, and issues emerged in the areas of terms and conditions of employment; communication; involvement; sound business planning; ethics and fairness; community infrastructure. From the aggregated opinion of the participants, it is recommended that decision-makers: Plan using sound business principles and continually communicate plans to the workforce; Respect workforce investments in the Laboratory; Tell the workforce exactly what is going on at all times; Understand that economic growth in Northern New Mexico is not universally viewed as positive; and Establish dialog with stakeholders on growth issues.

  5. Workshop on crystals and focusing

    Science.gov (United States)

    Berreman, D. W.

    1980-12-01

    The purpose of the workshop on crystals and focusing was to exchange and pool the experience and information that the participants could contribute on the design and construction of monochromators for EXAFS with optimum speed, resolution and versatility. The panel was chaired by D.W. Berreman of BTL and included G. G. Cohen of NBS, S. Heald of Brookhaven National Labs and Lu Kun-quan of U. of Washington. Written contributions for the workshop were made by R. J. Emrich and J. R. Katzer of U. of Delaware, R. C. Gamble of Cal. Tech., J. Crane of Cal. Tech., and T. Matsushita of S. S. R. L. G. Bunker of U. of Washington was recording secretary, G. G. Cohen and S. Heald gave invited papers on the main program that were relevant to the workshop. Other contributors were R. Hänsel of U. of Kiel, W. Germany, G. Christoff of Ohio State and D. Hempstead of Rigaku/USA Inc., J. Holben of Marconi Avionics, Hertfordshire, England and J. Hastings of Brookhaven N. L.

  6. Focused conformational sampling in proteins

    Science.gov (United States)

    Bacci, Marco; Langini, Cassiano; Vymětal, Jiří; Caflisch, Amedeo; Vitalis, Andreas

    2017-11-01

    A detailed understanding of the conformational dynamics of biological molecules is difficult to obtain by experimental techniques due to resolution limitations in both time and space. Computer simulations avoid these in theory but are often too short to sample rare events reliably. Here we show that the progress index-guided sampling (PIGS) protocol can be used to enhance the sampling of rare events in selected parts of biomolecules without perturbing the remainder of the system. The method is very easy to use as it only requires as essential input a set of several features representing the parts of interest sufficiently. In this feature space, new states are discovered by spontaneous fluctuations alone and in unsupervised fashion. Because there are no energetic biases acting on phase space variables or projections thereof, the trajectories PIGS generates can be analyzed directly in the framework of transition networks. We demonstrate the possibility and usefulness of such focused explorations of biomolecules with two loops that are part of the binding sites of bromodomains, a family of epigenetic "reader" modules. This real-life application uncovers states that are structurally and kinetically far away from the initial crystallographic structures and are also metastable. Representative conformations are intended to be used in future high-throughput virtual screening campaigns.

  7. FORMATION CONSTANTS AND THERMODYNAMIC ...

    African Journals Online (AJOL)

    KEY WORDS: Metal complexes, Schiff base ligand, Formation constant, DFT calculation ... best values for the formation constants of the proposed equilibrium model by .... to its positive charge distribution and the ligand deformation geometry.

  8. Cobalt alloy ion sources for focused ion beam implantation

    Energy Technology Data Exchange (ETDEWEB)

    Muehle, R.; Doebeli, M. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Zimmermann, P. [Eidgenoessische Technische Hochschule, Zurich (Switzerland)

    1997-09-01

    Cobalt alloy ion sources have been developed for silicide formation by focused ion beam implantation. Four eutectic alloys AuCo, CoGe, CoY and AuCoGe were produced by electron beam welding. The AuCo liquid alloy ion source was investigated in detail. We have measured the emission current stability, the current-voltage characteristics, and the mass spectrum as a function of the mission current. (author) 1 fig., 2 refs.

  9. Conceptual Design and Simulation of a Miniature Plasma Focus

    International Nuclear Information System (INIS)

    Jafari, H.; Habibi, M.; Amrollahi, R.

    2012-01-01

    Design and construction of a miniature plasma focus device with 3.6 J of energy bank is reported. In design the device, some of very important parameters of designing such as plasma energy density and derive parameter was used. Regarding to the electrical and geometrical parameters of the device, a simulation is carried out by MATLAB software. Simulation results showed that the formation of the pinch have occurred at the moment of the peak discharge current.

  10. Free-format RPG IV the express guide to learning free format

    CERN Document Server

    Martin, Jim

    2015-01-01

    Focusing strictly on teaching free-format RPG programming methods, this book will help programmers wishing to upgrade their skills   This how-to guide offers a concise and thorough introduction to the increased productivity, better readability, and easier program maintenance that comes with the free-format style of programming in RPG IV. Although free-format information is available in IBM manuals, it is not separated from everything else, requiring hours of tedious research to track down the information needed. This book provides everything you need to know to write RPG IV in the free-format

  11. Focusing on Cause or Cure?

    Science.gov (United States)

    Milner, Lauren C.; Cho, Mildred K.

    2013-01-01

    Background Biomedical research is influenced by many factors, including the involvement of stakeholder groups invested in research outcomes. Stakeholder involvement in research efforts raise questions of justice as their specific interests and motivations play a role in directing research resources that ultimately produce knowledge shaping how different conditions (and affected individuals) are understood and treated by society. This issue is highly relevant to child psychiatry research where diagnostic criteria and treatment strategies are often controversial. Biological similarities and stakeholder differences between attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) provide an opportunity to explore this issue by comparing research foci and stakeholder involvement in these conditions. Methods A subset of ADHD and ASD research articles published between 1970-2010 were randomly selected from the PubMed database and coded for research focus, funding source(s), and author-reported conflicts of interest (COIs). Chi-square analyses were performed to identify differences between and within ADHD and ASD research across time. Results The proportion of ADHD research dedicated to basic, description, and treatment research was roughly similar and remained stable over time, while ASD research showed a significant increase in basic research over the past decade. Government was the primary research funder for both conditions, but for-profit funders were a notable presence in ADHD research, while joint-funding efforts between non-profit and government funders were a notable presence in ASD research. Lastly, COIs were noted more frequently in ADHD than in ASD research. Conclusions Our study shows significant differences in research foci and funding sources between the conditions, and identifies the specific involvement of for-profit and non-profit groups in ADHD and ASD, respectively. Our findings highlight the relationship between stakeholders

  12. Theory of aurora formation

    International Nuclear Information System (INIS)

    Hasegawa, Akira.

    1975-04-01

    A new theory of aurora formation is presented based on Alfven wave-electron interaction. The theory explains consistently 1) the electron acceleration process, 2) the formation of auroral layers and 3) the long wave formation in the longitudinal direction. (auth.)

  13. Parametric studies in a small plasma focus device

    International Nuclear Information System (INIS)

    Chuaqui, H.; Favre, M.; Silva, P.; Wyndham, E.

    1996-01-01

    Very high temperature and density plasmas can be produced in modest size plasma focus devices at the kJ level. Much of the scaling parameters on the plasma focus have been evaluated, though many questions still remain. The modest cost and simple construction allows easy modification to the device and the discharge parameters. In this paper the authors report on a small plasma focus device, which is set-up to investigate the effect of some of those modifications on the plasma, with detailed experimental diagnostics. Experiments have been carried out in various gases and with mixtures of different ratios. Extended operating range from below 0.5 torr upwards has been achieved with the implementation of the auxiliary discharge circuit. Despite the low voltage and low energy operation, energetic beam formation has been observed at the time of the final compression, prior to disruption. Current sheath formation and evolution has been characterized using the magnetic probes array, in correlation with beam formation and plasma emission. The relationship of the current sheath structure and that of the pinched plasma, as shown by the filtered X-ray pinhole camera, has been investigated

  14. Focus groups reveal consumer ambivalence.

    Science.gov (United States)

    1983-01-01

    According to qualitative research, Salvadoreans are ambivalent about the use of contraceptives. Since complete responsibility for management of the CSM project was accepted by the Association Demografica Salvadorena (ADS), the agency which operates the contraceptive social marketing project in El Salvador, in November 1980, the need for decisions in such areas as product price increases, introduction of new condom brands, promotion of the vaginal foaming tablet, and assessment of product sales performance had arisen. The ICSMP funded market research, completed during 1983, was intended to provide the data on which such decisions by ADS could be based. The qualitative research involved 8 focus groups, comprised of men and women, aged 18-45, contraceptive users and nonusers, from the middle and lower socioeconomic strata of the city of San Salvador and other suburban areas. In each group a moderator led discussion of family planning and probed respondents for specific attitudes, knowledge, and behavior regarding the use of contraceptives. To assess attitudes at a more emotional level, moderators asked respondents to "draw" their ideas on certain issues. A marked discrepancy was revealed between respondents' intellectual responses to the issues raised in group discussion, as opposed to their feelings expressed in the drawings. Intellectually, participants responded very positively to family planning practice, but when they were asked to draw their perceptions, ambivalent feelings emerged. Drawings of both the user and the nonuser convey primarily negative aspects for either choice. The user is tense and moody toward her children; the nonuser loses her attractiveness and "dies." Figures also show drawings of some of the attitudes of single and married male participants. 1 drawing shows an incomplete and a complete circle, symbolizing a sterilized man (incomplete) and a nonsterilized man (complete). Another picture depicts a chained man who has lost his freedom

  15. Keep the focus on emissions

    Science.gov (United States)

    Clack, C.; Benson, S. M.; Peterson, P.; Long, J. C. S.

    2016-12-01

    Most think that the major battle over climate is between those that want to solve the climate problem and the climate deniers. But there is another conflict, perhaps equally significant between people who all agree climate is a problem but who disagree radically about what they think the solution is. The imperative for stopping further climate change is to stop GHG emissions and the first energy sector of importance is electricity. Every major plan to eliminate emmissions from energy requires a carbon-free electricity system. The most popular idea about how to do this is to use all renewable energy, i.e. solar and wind power. But no one has ever built a large scale 100% renewable energy system and the few examples we have about regions that have tried are not encouraging. As the percentage of renewable energy goes up, ensuring a reliable supply often requires a fossil-based back-up system, so emissions can actually increase. Also, 100% renewable systems rely on massive deployment rates, far beyond any historical precident and often assume that adequate energy storage will "happen" through a combination of currently unavailable technologies. This approach is about adding renewable capacity, not about reducing emissions. Sweden provides a counter example that relies entirely on nuclear power and hydro and has an emission-free, reliable energy system. Likewise, biofuel is often cited as a climate-friendly substitute for petroleum-based fuels. Life-cycle analsyis indicates biofuels are often worse than petroleum-based fuels. We focus efficiency measures on buildings, but efficiency in transportation is even more important because we don't really have the fuel that is carbon neutral. Vehicle efficiency and reductions in vehicle miles traveled does better to address emissions. As mitigation is so important, climate advocates used to think discussion of adaptation was a distraction that should be avoided. But losing track of the need to eliminate emissions is the real

  16. EDITORIAL: Focus on Plasma Medicine

    Science.gov (United States)

    Morfill, G. E.; Kong, M. G.; Zimmermann, J. L.

    2009-11-01

    'Plasma Healthcare' is an emerging interdisciplinary research topic of rapidly growing importance, exploring considerable opportunities at the interface of plasma physics, chemistry and engineering with life sciences. Some of the scientific discoveries reported so far have already demonstrated clear benefits for healthcare in areas of medicine, food safety, environmental hygiene, and cosmetics. Examples include ongoing studies of prion inactivation, chronic wound treatment and plasma-mediated cancer therapy. Current research ranges from basic physical processes, plasma chemical design, to the interaction of plasmas with (i) eukaryotic (mammalian) cells; (ii) prokaryotic (bacteria) cells, viruses, spores and fungi; (iii) DNA, lipids, proteins and cell membranes; and (iv) living human, animal and plant tissues in the presence of biofluids. Of diverse interests in this new field is the need for hospital disinfection, in particular with respect to the alarming increase in bacterial resistance to antibiotics, the concomitant needs in private practices, nursing homes etc, the applications in personal hygiene—and the enticing possibility to 'design' plasmas as possible pharmaceutical products, employing ionic as well as molecular agents for medical treatment. The 'delivery' of the reactive plasma agents occurs at the gaseous level, which means that there is no need for a carrier medium and access to the treatment surface is optimal. This focus issue provides a close look at the current state of the art in Plasma Medicine with a number of forefront research articles as well as an introductory review. Focus on Plasma Medicine Contents Application of epifluorescence scanning for monitoring the efficacy of protein removal by RF gas-plasma decontamination Helen C Baxter, Patricia R Richardson, Gaynor A Campbell, Valeri I Kovalev, Robert Maier, James S Barton, Anita C Jones, Greg DeLarge, Mark Casey and Robert L Baxter Inactivation factors of spore-forming bacteria using low

  17. EDITORIAL: Focus on Attosecond Physics

    Science.gov (United States)

    Bandrauk, André D.; Krausz, Ferenc; Starace, Anthony F.

    2008-02-01

    future involve using overdense plasmas. Electronic processes on sub-atomic spatio-temporal scales are the basis of chemical physics, atomic, molecular, and optical physics, materials science, and even some life science processes. Research in these areas using the new attosecond tools will advance together with the ability to control electrons themselves. Indeed, we expect that developments will advance in a way that is similar to advances that have occurred on the femtosecond time scale, in which much previous experimental and theoretical work on the interaction of coherent light sources has led to the development of means for 'coherent control' of nuclear motion in molecules. This focus issue of New Journal of Physics is centered on experimental and theoretical advances in the development of new methodologies and tools for electron control on the attosecond time scale. Topics such as the efficient generation of harmonics; the generation of attosecond pulses, including those having only a few cycles and those produced from overdense plasmas; the description of various nonlinear, nonperturbative laser-matter interactions, including many-electron effects and few-cycle pulse effects; the analysis of ultrashort propagation effects in atomic and molecular media; and the development of inversion methods for electron tomography, as well as many other topics, are addressed in the current focus issue dedicated to the new field of 'Attosecond Physics'. Focus on Attosecond Physics Contents Observing the attosecond dynamics of nuclear wavepackets in molecules by using high harmonic generation in mixed gases Tsuneto Kanai, Eiji J Takahashi, Yasuo Nabekawa and Katsumi Midorikawa Core-polarization effects in molecular high harmonic generation G Jordan and A Scrinzi Interferometric autocorrelation of an attosecond pulse train calculated using feasible formulae Y Nabekawa and K Midorikawa Attosecond pulse generation from aligned molecules—dynamics and propagation in H2+ E Lorin, S

  18. Ion Motion in the Adiabatic Focuser

    International Nuclear Information System (INIS)

    Henestroza, E.; Sessler, A.M.; Yu, S.S.

    2006-01-01

    In this paper we numerically study the effect of ion motion in an adiabatic focuser, motivated by a recent suggestion that ion motion in an adiabatic focuser might be significant and even preclude operation of the focuser as previously envisioned. It is shown that despite ion motion the adiabatic focuser should work as well as originally envisioned

  19. Focusing on butterfly eyespot focus: uncoupling of white spots from eyespot bodies in nymphalid butterflies.

    Science.gov (United States)

    Iwata, Masaki; Otaki, Joji M

    2016-01-01

    Developmental studies on butterfly wing color patterns often focus on eyespots. A typical eyespot (such as that of Bicyclus anynana) has a few concentric rings of dark and light colors and a white spot (called a focus) at the center. The prospective eyespot center during the early pupal stage is known to act as an organizing center. It has often been assumed, according to gradient models for positional information, that a white spot in adult wings corresponds to an organizing center and that the size of the white spot indicates how active that organizing center was. However, there is no supporting evidence for these assumptions. To evaluate the feasibility of these assumptions in nymphalid butterflies, we studied the unique color patterns of Calisto tasajera (Nymphalidae, Satyrinae), which have not been analyzed before in the literature. In the anterior forewing, one white spot was located at the center of an eyespot, but another white spot associated with either no or only a small eyespot was present in the adjacent compartment. The anterior hindwing contained two adjacent white spots not associated with eyespots, one of which showed a sparse pattern. The posterior hindwing contained two adjacent pear-shaped eyespots, and the white spots were located at the proximal side or even outside the eyespot bodies. The successive white spots within a single compartment along the midline in the posterior hindwing showed a possible trajectory of a positional determination process for the white spots. Several cases of focus-less eyespots in other nymphalid butterflies were also presented. These results argue for the uncoupling of white spots from eyespot bodies, suggesting that an eyespot organizing center does not necessarily differentiate into a white spot and that a prospective white spot does not necessarily signify organizing activity for an eyespot. Incorporation of these results in future models for butterfly wing color pattern formation is encouraged.

  20. Focusing procedures in time-of-flight mass spectrometry

    International Nuclear Information System (INIS)

    Ioanoviciu, D.

    2002-01-01

    Time-of-flight mass spectrometry is a fast growing field due to its ability to handle very fast processes and due to its theoretically unlimited mass range. The performances of the time-of-flight mass analysers are heavily dependent on the progress in ion optics, a periodically reviewed field. In this presentation the various focusing procedures in time-of-flight mass spectrometry are reviewed. For ions of the same charge and mass flight time differences result from different potentials at the location of formation and from the initial velocity spread. There is no simultaneous space and velocity focusing in time-of-flight mass spectrometry. Space focusing of first and second order can be reached in time-of-flight mass analysers having two homogeneous electric field ion sources followed by a field free space in front of the detector. Single and double stage homogeneous electric field mirrors can focus in time ions of different energies. These different energies result when ions leaving different initial sites and arriving simultaneously to an intermediate space focus. Convenient mass dispersion can be obtained by including a mirror. Initial velocity focusing is obtained by the delayed extraction procedure in drift space and mirror time-of-flight mass analysers. Post source pulse focusing aims at the same purpose. Ion source electrodes of hyperbolic shape, operated by high voltage pulses can bring major improvements of the resolution, especially at high masses. For each focusing procedure the geometric and/or electric conditions are given as well as the aberrations allowing the mass resolution determination. The various focusing procedures are compared and a prediction of their future performances was tempted. (author)

  1. EDITORIAL: Focus on Gravitational Lensing

    Science.gov (United States)

    Jain, Bhuvnesh

    2007-11-01

    Gravitational lensing emerged as an observational field following the 1979 discovery of a doubly imaged quasar lensed by a foreground galaxy. In the 1980s and '90s dozens of other multiply imaged systems were observed, as well as time delay measurements, weak and strong lensing by galaxies and galaxy clusters, and the discovery of microlensing in our galaxy. The rapid pace of advances has continued into the new century. Lensing is currently one of best techniques for finding and mapping dark matter over a wide range of scales, and also addresses broader cosmological questions such as understanding the nature of dark energy. This focus issue of New Journal of Physics presents a snapshot of current research in some of the exciting areas of lensing. It provides an occasion to look back at the advances of the last decade and ahead to the potential of the coming years. Just about a decade ago, microlensing was discovered through the magnification of stars in our galaxy by invisible objects with masses between that of Jupiter and a tenth the mass of the Sun. Thus a new component of the mass of our galaxy, dubbed MACHOs, was established (though a diffuse, cold dark matter-like component is still needed to make up most of the galaxy mass). More recently, microlensing led to another exciting discovery—of extra-solar planets with masses ranging from about five times that of Earth to that of Neptune. We can expect many more planets to be discovered through ongoing surveys. Microlensing is the best technique for finding Earth mass planets, though it is not as productive overall as other methods and does not allow for follow up observations. Beyond planet hunting, microlensing has enabled us to observe previously inaccessible systems, ranging from the surfaces of other stars to the accretion disks around the black holes powering distant quasars. Galaxies and galaxy clusters at cosmological distances can produce dramatic lensing effects: multiple images of background galaxies

  2. Amadori products formation in emulsified systems

    NARCIS (Netherlands)

    Troise, Antonio Dario; Berton-Carabin, Claire C.; Fogliano, Vincenzo

    2016-01-01

    The formation of Amadori products (APs) is the key step determining the development of the Maillard reaction (MR). The information on the chemical behaviour of the reaction between amino acids and reducing sugars in emulsions during thermal treatments is scanty and mainly focused on volatile

  3. Input Enhancement and L2 Question Formation.

    Science.gov (United States)

    White, Lydia; And Others

    1991-01-01

    Investigated the extent to which form-focused instruction and corrective feedback (i.e., "input enhancement"), provided within a primarily communicative program, contribute to learners' accuracy in question formation. Study results are interpreted as evidence that input enhancement can bring about genuine changes in learners' interlanguage…

  4. Hydrogeological evaluation of geological formations in Ashanti ...

    African Journals Online (AJOL)

    This study, therefore, employed Geographical Information System to assess some of these hydrogeological parameters in the Ashanti Region using the ordinary kriging interpolation method. Data on 2,788 drilled boreholes in the region were used and the assessment focused on the various geological formations in the ...

  5. Stages of ores formation

    International Nuclear Information System (INIS)

    Khasanov, A.Kh.

    1988-01-01

    Deposit formation (especially endogenous) is the complicated, multi-stage and long process. Establishment of deposit formation succession, age-specific correlations of minerals and aggregates have a high importance at solving genetic questions. Studying of minerals correlations and mineral aggregates, succession of their crystallization and other observations let restore the history of deposit formation, pick up in it different on duration and physical and chemical conditions stages

  6. Planet formation in Binaries

    OpenAIRE

    Thebault, Ph.; Haghighipour, N.

    2014-01-01

    Spurred by the discovery of numerous exoplanets in multiple systems, binaries have become in recent years one of the main topics in planet formation research. Numerous studies have investigated to what extent the presence of a stellar companion can affect the planet formation process. Such studies have implications that can reach beyond the sole context of binaries, as they allow to test certain aspects of the planet formation scenario by submitting them to extreme environments. We review her...

  7. Data format translation routines

    International Nuclear Information System (INIS)

    Burris, R.D.

    1981-02-01

    To enable the effective connection of several dissimilar computers into a network, modification of the data being passed from one computer to another may become necessary. This document describes a package of routines which permit the translation of data in PDP-8 formats to PDP-11 or DECsystem-10 formats or from PDP-11 format to DECsystem-10 format. Additional routines are described which permit the effective use of the translation routines in the environment of the Fusion Energy Division (FED) network and the Elmo Bumpy Torus (EBT) data base

  8. ENDF/B format

    International Nuclear Information System (INIS)

    Khalil, M.A.; Lemmel, H.D.

    1986-09-01

    This document is a brief user's description of the format of ENDF/B. This format, originally designed for the US Evaluated Nuclear Data File, is recommended for international use. This summary is an aid to customers of the IAEA Nuclear Data Section when receiving data retrievals in ENDF/B format. For more detailed information the report BNL-NCS-50496 (ENDF 102) should be consulted. An Appendix to the present document gives a summary of the format differences between ENDF/B-4 and ENDF/B-5. (author)

  9. Exploring Opponent Formats

    DEFF Research Database (Denmark)

    Jensen, Mads Møller; Rasmussen, Majken; Grønbæk, Kaj

    2013-01-01

    of how the opponent format and relationships impact a game are almost absent in current research. Thus, this paper aims to elucidate how the perception of a competition differs, depending on the opponent format, by presenting a game mechanic framework. The paper furthermore presents an interactive...... football-training platform, as well as games designed to explore the different opponent formats. The games are qualitatively evaluated to illuminate the qualities of and distinctions between different types of opponent formats, proposed by the framework terminology....

  10. To the problem of spatial focusing of ultracold neutrons by nonuniform magnetic field. Eikonal approximation

    CERN Document Server

    Chen, T

    2002-01-01

    Motion of the ultracold neutrons in the nonuniform magnetic field with a square nonuniformity by two coordinates is considered. The Schroedinger equation is solved with application of the quasi-classical (eikonal) approach. The theoretical possibility of the neutrons spatial focusing with formation of the point focus and also the neutrons bunches is shown

  11. Night Vision Goggles Objectives Lens Focusing Methodology

    National Research Council Canada - National Science Library

    Pinkus, Alan; Task, H. L

    2000-01-01

    ...: interpupillary distance, tilt, eye relief, height, eyepiece and objective lens focus. Currently, aircrew use a Hoffman 20/20 test unit to pre-focus their NVG objective lenses at optical infinity before boarding their aircraft...

  12. Self-focusing in laser produced spark

    International Nuclear Information System (INIS)

    Bakos, J.S.; Foeldes, I.B.

    1983-05-01

    The self-focusing effect appearing in different phases of development of laser produced breakdown plasma in air is investigated. Self-focusing during the ionization process is demonstrated. Thermal self-focusing was observed in the later stage of the plasma development at moderate light intensities. Plasma development was investigated by forward and side scattering of the laser light in the plasma. A crossed beam experiment gave evidence of the thermal mechanism of self-focusing. (author)

  13. Near-field flat focusing mirrors

    Science.gov (United States)

    Cheng, Yu-Chieh; Staliunas, Kestutis

    2018-03-01

    This article reviews recent progress towards the design of near-field flat focusing mirrors, focusing/imaging light patterns in reflection. An important feature of such flat focusing mirrors is their transverse invariance, as they do not possess any optical axis. We start with a review of the physical background to the different focusing mechanisms of near- and far-field focusing. These near-field focusing devices like flat lenses and the reviewed near-field focusing mirrors can implement planar focusing devices without any optical axis. In contrast, various types of far-field planar focusing devices, such as high-contrast gratings and metasurfaces, unavoidably break the transverse invariance due to their radially symmetrical structures. The particular realizations of near-field flat focusing mirrors including Bragg-like dielectric mirrors and dielectric subwavelength gratings are the main subjects of the review. The first flat focusing mirror was demonstrated with a chirped mirror and was shown to manage an angular dispersion for beam focusing, similar to the management of chromatic dispersion for pulse compression. Furthermore, the reviewed optimized chirped mirror demonstrated a long near-field focal length, hardly achieved by a flat lens or a planar hyperlens. Two more different configurations of dielectric subwavelength gratings that focus a light beam at normal or oblique incidence are also reviewed. We also summarize and compare focusing performance, limitations, and future perspectives between the reviewed flat focusing mirrors and other planar focusing devices including a flat lens with a negative-index material, a planar hyperlens, a high-contrast grating, and a metasurface.

  14. ENDF/B Format

    International Nuclear Information System (INIS)

    Khalil, M.A.

    1975-01-01

    This document is a brief user's description of the format of ENDF/B, the evaluated neutron nuclear data library of the US National Nuclear Data Center. This summary is an aid to customers of the IAEA Nuclear Data Section when receiving data retrievals in ENDF/B format. For more detailed information the report BNL-50274 (ENDF-102) should be consulted. (author)

  15. Formation of multiple networks

    DEFF Research Database (Denmark)

    Magnani, Matteo; Rossi, Luca

    2013-01-01

    we introduce the first network formation model for multiple networks. Network formation models are among the most popular tools in traditional network studies, because of both their practical and theoretical impact. However, existing models are not sufficient to describe the generation of multiple...

  16. The Role of Emotions in Delusion Formation

    Directory of Open Access Journals (Sweden)

    Smurzyńska Adrianna

    2016-12-01

    Full Text Available The text concerns the role of emotions in delusion formation. Provided are definitions from DSM-V and DSM-IV-R and the problems found in those definitions. One of them, the problem of delusion formation, is described when providing cognitive theories of delusions. The core of the paper is a presentation of the emotional and affective disorders in delusions, especially Capgras delusion and Cotard delusion. The author provides a comparison of the kinds of delusions and the conclusions taken from neuroimaging studies. As a result of the fact that an explanation of delusion formation focusing on emotional problems turns out to be insufficient, the author provides examples of the reasoning impairments which coexist with them. At the end of the article, some hypotheses are proposed concerning the role of emotions and reasoning in delusion formation and the relation between belief disorders and emotional disorders.

  17. Development of multilayer Fresnel lens (zone plate) for formation of focused neutron beam

    International Nuclear Information System (INIS)

    Tamura, Shigeharu

    2008-01-01

    Multilayer Fresnel zone plates (FZPs) for the neutron beamline have been designed and fabricated. Firstly, materials for the FZP were examined: layer materials, wire substrate, etc. Secondly, FZPs were designed and three kinds of FZPs were fabricated: two Cu/Al-FZPs and a Ni(Cr)/Al-FZP. (author)

  18. Wide-Angle Multistatic Synthetic Aperture Radar: Focused Image Formation and Aliasing Artifact Mitigation

    National Research Council Canada - National Science Library

    Luminati, Jonathan E

    2005-01-01

    ...) imagery from a Radar Cross Section (RCS) chamber validates this approach. The second implementation problem stems from the large Doppler spread in the wide-angle scene, leading to severe aliasing problems...

  19. Usage Record Format Recommendation

    CERN Document Server

    Nilsen, J.K.; Muller-Pfeerkorn, R

    2013-01-01

    For resources to be shared, sites must be able to exchange basic accounting and usage data in a common format. This document describes a common format which enables the exchange of basic accounting and usage data from different resources. This record format is intended to facilitate the sharing of usage information, particularly in the area of the accounting of jobs, computing, memory, storage and cloud usage but with a structure that allows an easy extension to other resources. This document describes the Usage Record components both in natural language form and annotated XML. This document does not address how these records should be used, nor does it attempt to dictate the format in which the accounting records are stored. Instead, it denes a common exchange format. Furthermore, nothing is said regarding the communication mechanisms employed to exchange the records, i.e. transport layer, framing, authentication, integrity, etc.

  20. Prevention and curative management of hypertrophic scar formation

    NARCIS (Netherlands)

    Bloemen, M.C.; Veer, van der W.M.; Ulrich, M.; Zuijlen, van P.P.; Niessen, F.B.; Middelkoop, E.

    2009-01-01

    Although hypertrophic scarring commonly occurs following burns, many aspects such as incidence of and optimal treatment for scar hypertrophy remain unclear. This review will focus on hypertrophic scar formation after burn in particular, exploring multiple treatment options and describing their

  1. Real Time Control Software for Electromagnetic Formation Flight, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — As the focus of space system architectures changes from single, to multiple, and eventually to many spacecraft flying in formation, a greater demand on total...

  2. Formative Assessment Probes: Mountaintop Fossil: A Puzzling Phenomenon

    Science.gov (United States)

    Keeley, Page

    2015-01-01

    This column focuses on promoting learning through assessment. This month's issue describes using formative assessment probes to uncover several ways of thinking about the puzzling discovery of a marine fossil on top of a mountain.

  3. Chloride Transport in Heterogeneous Formation

    Science.gov (United States)

    Mukherjee, A.; Holt, R. M.

    2017-12-01

    The chloride mass balance (CMB) is a commonly-used method for estimating groundwater recharge. Observations of the vertical distribution of pore-water chloride are related to the groundwater infiltration rates (i.e. recharge rates). In CMB method, the chloride distribution is attributed mainly to the assumption of one dimensional piston flow. In many places, however, the vertical distribution of chloride will be influenced by heterogeneity, leading to horizontal movement of infiltrating waters. The impact of heterogeneity will be particularly important when recharge is locally focused. When recharge is focused in an area, horizontal movement of chloride-bearing waters, coupled with upward movement driven by evapotranspiration, may lead to chloride bulges that could be misinterpreted if the CMB method is used to estimate recharge. We numerically simulate chloride transport and evaluate the validity of the CMB method in highly heterogeneous systems. This simulation is conducted for the unsaturated zone of Ogallala, Antlers, and Gatuna (OAG) formations in Andrews County, Texas. A two dimensional finite element model will show the movement of chloride through heterogeneous systems. We expect to see chloride bulges not only close to the surface but also at depths characterized by horizontal or upward movement. A comparative study of focused recharge estimates in this study with available recharge data will be presented.

  4. Formation of interstellar anions

    Science.gov (United States)

    Senent, Maria Luisa

    2012-05-01

    Formation of interstellar anions: M.L. Senent. The recent detection of negative charged species in the ISM1 has instigated enthusiasm for anions in the astrophysical community2. Many of these species are new and entail characterization. How they are formed in astrophysical sources is a question of major relevance. The anion presence in ISM was first predicted theoretically on the basis of electron affinities and on the negative linear chain molecular stabilities. Although very early, they were considered in astrochemical models3-4, their discovery is so recent because their abundances seem to be relatively low. These have to be understood in terms of molecular stabilities, reaction probabilities and radiative and collisional excitations. Then, we present our theoretical work on even carbon chains type Cn and CnH (n=2,4,6) focused to the understanding of anion abundances. We use highly correlated ab initio methods. We performed spectroscopic studies of various isomers that can play important roles as intermediates5-8. In previous papers9-10, we compared C2H and C2H- collisional rates responsible for observed line intensities. Actually, we study hydrogen attachment (Cn +H → CnH and Cn- +H → CnH-) and associative detachment processes (Cn- +H → CnH +e-) for 2, 4 and 6 carbon atom chains11. [1] M.C.McCarthy, C.A.Gottlieb, H.Gupta, P.Thaddeus, Astrophys.J, 652, L141 (2006) [2] V.M.Bierbaum, J.Cernicharo, R.Bachiller, eds., 2011, pp 383-389. [3] A. Dalgarno, R.A. Mc Cray, Astrophys.J,, 181, 95 (1973) [4] E. Herbst E., Nature, 289, 656 (1981); [5] H.Massó, M.L.Senent, P.Rosmus, M.Hochlaf, J.Chem.Phys., 124, 234304 (2006) [6] M.L.Senent, M.Hochlaf, Astrophys. J. , 708, 1452(2010) [7] H.Massó, M.L.Senent, J.Phys.Chem.A, 113, 12404 (2009) [8] D. Hammoutene, M.Hochlaf, M.L.Senent, submitted. [9] A. Spielfiedel, N. Feautrier, F. Najar, D. ben Abdallah, F. Dayou, M.L. Senent, F. Lique, Mon.Not.R.Astron.Soc., 421, 1891 (2012) [10] F.Dumouchel, A, Spielfieldel , M

  5. Analysis and modeling of "focus" in context

    DEFF Research Database (Denmark)

    Hovy, Dirk; Anumanchipalli, Gopala; Parlikar, Alok

    2013-01-01

    This paper uses a crowd-sourced definition of a speech phenomenon we have called focus. Given sentences, text and speech, in isolation and in context, we asked annotators to identify what we term the focus word. We present their consistency in identifying the focused word, when presented with text...... or speech stimuli. We then build models to show how well we predict that focus word from lexical (and higher) level features. Also, using spectral and prosodic information, we show the differences in these focus words when spoken with and without context. Finally, we show how we can improve speech synthesis...

  6. Synthetic focusing in ultrasound modulated tomography

    KAUST Repository

    Kuchment, Peter; Kunyansky, Leonid

    2010-01-01

    Several hybrid tomographic methods utilizing ultrasound modulation have been introduced lately. Success of these methods hinges on the feasibility of focusing ultrasound waves at an arbitrary point of interest. Such focusing, however, is difficult to achieve in practice. We thus propose a way to avoid the use of focused waves through what we call synthetic focusing, i.e. by reconstructing the would-be response to the focused modulation from the measurements corresponding to realistic unfocused waves. Examples of reconstructions from simulated data are provided. This non-technical paper describes only the general concept, while technical details will appear elsewhere. © 2010 American Institute of Mathematical Sciences.

  7. Synthetic focusing in ultrasound modulated tomography

    KAUST Repository

    Kuchment, Peter

    2010-09-01

    Several hybrid tomographic methods utilizing ultrasound modulation have been introduced lately. Success of these methods hinges on the feasibility of focusing ultrasound waves at an arbitrary point of interest. Such focusing, however, is difficult to achieve in practice. We thus propose a way to avoid the use of focused waves through what we call synthetic focusing, i.e. by reconstructing the would-be response to the focused modulation from the measurements corresponding to realistic unfocused waves. Examples of reconstructions from simulated data are provided. This non-technical paper describes only the general concept, while technical details will appear elsewhere. © 2010 American Institute of Mathematical Sciences.

  8. Characterization of bismuth nanospheres deposited by plasma focus device

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, M., E-mail: cscientific2@aec.org.sy [IBA Laboratory, Chemistry Department, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus (Syrian Arab Republic); Al-Hawat, Sh.; Akel, M. [Physics Department, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus (Syrian Arab Republic); Mrad, O. [Chemistry Department, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus (Syrian Arab Republic)

    2015-02-14

    A new method for producing thin layer of bismuth nanospheres based on the use of low energy plasma focus device is demonstrated. Various techniques such as scanning electron microscopy, Rutherford backscattering spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and Raman spectroscopy have been used to characterize the morphology and the composition of the nanospheres. Experimental parameters may be adjusted to favour the formation of bismuth nanospheres instead of microspheres. Therefore, the formation of large surface of homogeneous layer of bismuth nanospheres with sizes of below 100 nm can be obtained. The natural snowball phenomenon is observed to be reproduced in nanoscale where spheres roll over the small nanospheres and grow up to bigger sizes that can reach micro dimensions. The comet-like structure, a reverse phenomenon to snowball is also observed.

  9. Characterization of bismuth nanospheres deposited by plasma focus device

    International Nuclear Information System (INIS)

    Ahmad, M.; Al-Hawat, Sh.; Akel, M.; Mrad, O.

    2015-01-01

    A new method for producing thin layer of bismuth nanospheres based on the use of low energy plasma focus device is demonstrated. Various techniques such as scanning electron microscopy, Rutherford backscattering spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and Raman spectroscopy have been used to characterize the morphology and the composition of the nanospheres. Experimental parameters may be adjusted to favour the formation of bismuth nanospheres instead of microspheres. Therefore, the formation of large surface of homogeneous layer of bismuth nanospheres with sizes of below 100 nm can be obtained. The natural snowball phenomenon is observed to be reproduced in nanoscale where spheres roll over the small nanospheres and grow up to bigger sizes that can reach micro dimensions. The comet-like structure, a reverse phenomenon to snowball is also observed

  10. Non-hydrodynamic model of plasma focus structure

    International Nuclear Information System (INIS)

    Imshennik, V.S.; Zueva, N.M.; Lokutsievskij, O.V.; Mikhajlova, M.S.

    1985-01-01

    Experimental and theoretical plasma focus study has resulted in the necessity of creating a non-hydrodynamic plasma focus structure model (MKHD model). This model describes the final stage of plasma focus, which starts immediately after maximum plasma compression. It is related to a very limited space near the neck of the sausage instability. The MKHD model is two-dimensional, axially symmetric and collisionless with respect to the ions and magnetohydrodynamic with respect to the electrons; it accounts for the pinch instability of the sausage type (m=0 mode). The MKHD model, first of all, explains the long time of the plasma focus existence and non-thermonuclear peculiarities in the neutron yield. The initial and boundary conditions are formulated in accordance with the experiments and the results of computations in the 2D MHD model. A non-stationary process of plasma focus dynamics is studied numerically for a relatively long time - about 20 ns; this time is, in principle, not restricted. The computations show that the external edge of the neck expands rather slowly (at a speed that is lower than the thermal ion velocity, by an order of magnitude), and the magnetic field energy is converted to the kinetic energy of the chaotic ion motion (which is doubled for the time of computation). A 'supra-thermal' tail (with the deuterium ion energy higher than 10 keV) forms slowly at the ion distribution function; this tail determines a substantial part of the total neutron yield. The formation of stable vortices, which actually determine the structure of the plasma flow during the developed non-hydrodynamic stage of the plasma focus, is also found in the computations. These properties of the development of the sausage instability, as found in the numerical experiment with the MKHD plasma focus model, are in qualitative agreement with the behaviour of an instability of the same type in the MHD models of the Z-pinch

  11. Formation Control for the MAXIM Mission

    Science.gov (United States)

    Luquette, Richard J.; Leitner, Jesse; Gendreau, Keith; Sanner, Robert M.

    2004-01-01

    Over the next twenty years, a wave of change is occurring in the space-based scientific remote sensing community. While the fundamental limits in the spatial and angular resolution achievable in spacecraft have been reached, based on today s technology, an expansive new technology base has appeared over the past decade in the area of Distributed Space Systems (DSS). A key subset of the DSS technology area is that which covers precision formation flying of space vehicles. Through precision formation flying, the baselines, previously defined by the largest monolithic structure which could fit in the largest launch vehicle fairing, are now virtually unlimited. Several missions including the Micro-Arcsecond X-ray Imaging Mission (MAXIM), and the Stellar Imager will drive the formation flying challenges to achieve unprecedented baselines for high resolution, extended-scene, interferometry in the ultraviolet and X-ray regimes. This paper focuses on establishing the feasibility for the formation control of the MAXIM mission. MAXIM formation flying requirements are on the order of microns, while Stellar Imager mission requirements are on the order of nanometers. This paper specifically addresses: (1) high-level science requirements for these missions and how they evolve into engineering requirements; and (2) the development of linearized equations of relative motion for a formation operating in an n-body gravitational field. Linearized equations of motion provide the ground work for linear formation control designs.

  12. Fundamental limits to imaging resolution for focused ion beams

    International Nuclear Information System (INIS)

    Orloff, J.; Swanson, L.W.; Utlaut, M.

    1996-01-01

    This article investigates the limitations on the formation of focused ion beam images from secondary electrons. We use the notion of the information content of an image to account for the effects of resolution, contrast, and signal-to-noise ratio and show that there is a competition between the rate at which small features are sputtered away by the primary beam and the rate of collection of secondary electrons. We find that for small features, sputtering is the limit to imaging resolution, and that for extended small features (e.g., layered structures), rearrangement, redeposition, and differential sputtering rates may limit the resolution in some cases. copyright 1996 American Vacuum Society

  13. [Pre-verbality in focusing and the need for self check. An attempt at "focusing check"].

    Science.gov (United States)

    Masui, T; Ikemi, A; Murayama, S

    1983-06-01

    Though the Focusing process is not entirely non-verbal, in Focusing, careful attention is paid by the Focuser and the Listener to the pre-verbal experiential process. In other words, Focusing involves attending to the felt sense that is not easily expressed in words immediately. Hence, during the process of learning to Focus, the Focusing teacher attempts to communicate the experiences of Focusing to the student which are not easily done by words. Due to such difficulties, the Focusing student may (and quite frequently does) mistake the experiential process in Focusing with other processes. Often, the felt sense can be confused with other phenomena such as "autogenic discharge". Also the Focuser may not stay with the felt sense and drift into "free association" or frequently, certain processes in "meditation" can be confused with Focusing. Therefore, there is a need for a "check" by which the Focusing student can confirm the Focusing experience for himself. For the Focusing student, such a "check" serves not only to confirm the Focusing process, but also an aid to learning Focusing. We will report here a "Focusing Check" which we developed by translating Eugene Gendlin's "Focusing Check" and making several modifications in it so that it will be more understandable to the Japanese. Along with the "Focusing Check" we developed, the authors discuss the need for such a check.

  14. Earth formation porosity log

    International Nuclear Information System (INIS)

    Smith, H.D.; Smith, M.P.; Schultz, W.E.

    1977-01-01

    A method for determining the porosity of earth formations in the vicinity of a cased well borehole is described, comprising the steps of: irradiating the earth formations in the vicinity of the cased well borehole with fast neutrons from a source of fast neutrons passed into the borehole; and generating a signal representative of the fast neutron population present in the well borehole at a location in the borehole, the signal is functionally related to the porosity of the earth formations in the vicinity of the borehole

  15. Manuel UNIMARC format bibliographique

    CERN Document Server

    2007-01-01

    This manual is the French translation of the second edition of UNIMARC Manual: bibliographic format published in English in 1994 and completed by 5 updates published from 1996 to 2005. This 5th French edition is composite. It reproduces identically a part of the 4th edition published in 2002 and, for the fields of the format modified in the Update 5, it offers a new more structured presentation. This is a handbook dedicated to French-speaking users of the UNIMARC format for bibliographic descriptions.

  16. The Formation of Supermassive Black Holes in the First Galaxies

    NARCIS (Netherlands)

    Schleicher, Dominik R. G.; Banerjee, Robi; Sur, Sharanya; Glover, Simon C. O.; Spaans, Marco; Klessen, Ralf S.

    2010-01-01

    We discuss the formation of supermassive black holes in the early universe, and how to probe their subsequent evolution with the upcoming mm/sub-mm telescope ALMA. We first focus on the chemical and radiative conditions for black hole formation, in particular considering radiation trapping and

  17. The Formation of Supermassive Black Holes in the First Galaxies

    NARCIS (Netherlands)

    Schleicher, Dominik R. G.; Banerjee, Robi; Sur, Sharanya; Glover, Simon C. O.; Spaans, Marco; Klessen, Ralf S.

    We discuss the formation of supermassive black holes in the early universe, and how to probe their subsequent evolution with the upcoming mm/sub-mm telescope ALMA. We first focus on the chemical and radiative conditions for black hole formation, in particular considering radiation trapping and

  18. Reduction of Bromate Formation During Ozonation of Drinking Water

    DEFF Research Database (Denmark)

    Antoniou, Maria; Sichel, C.; Andre, K.

    This study focused on the prevention of carcinogenic bromate formation during ozonation of tap water from the DTU university campus. To achieve this, different pre-treatments including pH-adjustment, ammonia addition and chlorine-ammonia addition, were tested. Formation of bromated was drastically...

  19. Deposition of aluminium nanoparticles using dense plasma focus device

    International Nuclear Information System (INIS)

    Devi, Naorem Bilasini; Srivastava, M P; Roy, Savita

    2010-01-01

    Plasma route to nanofabrication has drawn much attention recently. The dense plasma focus (DPF) device is used for depositing aluminium nanoparticles on n-type Si (111) wafer. The plasma chamber is filled with argon gas and evacuated at a pressure of 80 Pa. The substrate is placed at distances 4.0 cm, 5.0 cm and 6.0 cm from the top of the central anode. The aluminium is deposited on Si wafer at room temperature with two focused DPF shots. The deposits on the substrate are examined for their morphological properties using atomic force microscopy (AFM). The AFM images have shown the formation of aluminium nanoparticles. From the AFM images, it is found that the size of aluminium nanoparticles increases with increase in distance between the top of anode and the substrate for same number of DPF shots.

  20. Isothermal Martensite Formation

    DEFF Research Database (Denmark)

    Villa, Matteo

    Isothermal (i.e. time dependent) martensite formation in steel was first observed in the 40ies of the XXth century and is still treated as an anomaly in the description of martensite formation which is considered as a-thermal (i.e. independent of time). Recently, the clarification of the mechanism...... of lattice strains provided fundamental information on the state of stress in the material and clarified the role of the strain energy on martensite formation. Electron backscatter diffraction revealed that the microstructure of the material and the morphology of martensite were independent on the cooling...... leading to isothermal kinetics acquired new practical relevance because of the identification of isothermal martensite formation as the most likely process responsible for enhanced performances of sub-zero Celsius treated high carbon steel products. In the present work, different iron based alloys...

  1. Cosmology and galaxy formation

    International Nuclear Information System (INIS)

    Rees, M.J.

    1977-01-01

    Implications of the massive halos and ''missing mass'' for galaxy formation are addressed; it is suggested that this mass consists of ''Population III'' stars that formed before the galaxies did. 19 references

  2. Fracturing formations in wells

    Energy Technology Data Exchange (ETDEWEB)

    Daroza, R A

    1964-05-15

    This well stimulation method comprises introducing through the well bore a low-penetrating, dilatant fluid, and subjecting the fluid to sufficient pressure to produce fractures in the formation. The fluid is permitted to remain in contact with the formation so as to become diluted by the formation fluids, and thereby lose its properties of dilatancy. Also, a penetrating fluid, containing a propping agent suspended therein, in introduced into contact with the fractures at a pressure substantially reduced with respect to that pressure which would have been required, prior to the fracturing operation performed using the low-penetrating dilatant fluid. The propping agent is deposited within the fractures, and thereafter, fluid production is resumed from the fractured formation. (2 claims)

  3. Star formation: Cosmic feast

    Science.gov (United States)

    Scaringi, Simone

    2017-03-01

    Low-mass stars form through a process known as disk accretion, eating up material that orbits in a disk around them. It turns out that the same mechanism also describes the formation of more massive stars.

  4. Thermal self-focusing at oblique incidence

    International Nuclear Information System (INIS)

    Craxton, R.S.; McCrory, R.L.

    1984-03-01

    Thermal self-focusing at oblique incidence has been investigated in two-dimensional line-focus geometry using the Eulerian hydrodynamics simulation code SAGE. The laser beam interacts with a long-scale-length preformed plasma with an expontial density profiele. Questions to be addressed include: (1) What happens when a self-focusing channel reaches the turning point of the incident rays, and (2) Does the unabsorbed light return in the specular direction or back along the channel. A comparison is also made between thermal self-focusing at normal incidence in cylindrical and line-focus geometries: in cylindrical geometry the self-focusing mechanism is enhanced by the relative ease with which plasma may be expelled from a small cylindrical channel

  5. Formative assessment in mathematics for engineering students

    Science.gov (United States)

    Ní Fhloinn, Eabhnat; Carr, Michael

    2017-07-01

    In this paper, we present a range of formative assessment types for engineering mathematics, including in-class exercises, homework, mock examination questions, table quizzes, presentations, critical analyses of statistical papers, peer-to-peer teaching, online assessments and electronic voting systems. We provide practical tips for the implementation of such assessments, with a particular focus on time or resource constraints and large class sizes, as well as effective methods of feedback. In addition, we consider the benefits of such formative assessments for students and staff.

  6. PCF File Format.

    Energy Technology Data Exchange (ETDEWEB)

    Thoreson, Gregory G [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-08-01

    PCF files are binary files designed to contain gamma spectra and neutron count rates from radiation sensors. It is the native format for the GAmma Detector Response and Analysis Software (GADRAS) package [1]. It can contain multiple spectra and information about each spectrum such as energy calibration. This document outlines the format of the file that would allow one to write a computer program to parse and write such files.

  7. Plant Formate Dehydrogenase

    Energy Technology Data Exchange (ETDEWEB)

    John Markwell

    2005-01-10

    The research in this study identified formate dehydrogenase, an enzyme that plays a metabolic role on the periphery of one-carbon metabolism, has an unusual localization in Arabidopsis thaliana and that the enzyme has an unusual kinetic plasticity. These properties make it possible that this enzyme could be engineered to attempt to engineer plants with an improved photosynthetic efficiency. We have produced transgenic Arabidopsis and tobacco plants with increased expression of the formate dehydrogenase enzyme to initiate further studies.

  8. Self-consistent simulation studies of periodically focused intense charged-particle beams

    International Nuclear Information System (INIS)

    Chen, C.; Jameson, R.A.

    1995-01-01

    A self-consistent two-dimensional model is used to investigate intense charged-particle beam propagation through a periodic solenoidal focusing channel, particularly in the regime in which there is a mismatch between the beam and the focusing channel. The present self-consistent studies confirm that mismatched beams exhibit nonlinear resonances and chaotic behavior in the envelope evolution, as predicted by an earlier envelope analysis [C. Chen and R. C. Davidson, Phys. Rev. Lett. 72, 2195 (1994)]. Transient effects due to emittance growth are studied, and halo formation is investigated. The halo size is estimated. The halo characteristics for a periodic focusing channel are found to be qualitatively the same as those for a uniform focusing channel. A threshold condition is obtained numerically for halo formation in mismatched beams in a uniform focusing channel, which indicates that relative envelope mismatch must be kept well below 20% to prevent space-charge-dominated beams from developing halos

  9. Magnetic Assisted Colloidal Pattern Formation

    Science.gov (United States)

    Yang, Ye

    Pattern formation is a mysterious phenomenon occurring at all scales in nature. The beauty of the resulting structures and myriad of resulting properties occurring in naturally forming patterns have attracted great interest from scientists and engineers. One of the most convenient experimental models for studying pattern formation are colloidal particle suspensions, which can be used both to explore condensed matter phenomena and as a powerful fabrication technique for forming advanced materials. In my thesis, I have focused on the study of colloidal patterns, which can be conveniently tracked in an optical microscope yet can also be thermally equilibrated on experimentally relevant time scales, allowing for ground states and transitions between them to be studied with optical tracking algorithms. In particular, I have focused on systems that spontaneously organize due to particle-surface and particle-particle interactions, paying close attention to systems that can be dynamically adjusted with an externally applied magnetic or acoustic field. In the early stages of my doctoral studies, I developed a magnetic field manipulation technique to quantify the adhesion force between particles and surfaces. This manipulation technique is based on the magnetic dipolar interactions between colloidal particles and their "image dipoles" that appear within planar substrate. Since the particles interact with their own images, this system enables massively parallel surface force measurements (>100 measurements) in a single experiment, and allows statistical properties of particle-surface adhesion energies to be extracted as a function of loading rate. With this approach, I was able to probe sub-picoNewton surface interactions between colloidal particles and several substrates at the lowest force loading rates ever achieved. In the later stages of my doctoral studies, I focused on studying patterns formed from particle-particle interaction, which serve as an experimental model of

  10. New Office Software course format

    CERN Multimedia

    HR Department

    2010-01-01

    Always interested to anticipate your training needs, the Technical Training service is pleased to propose two new Office Software course formats : “Focus on... ” : On a monthly basis we will propose a theme such as “Sharepoint Collaboration Workspace” or “Word 2007” or “charts” etc. You will have to send us in advance your questions regarding the proposed topic and register for the course through our Training Catalogue. During the session, our trainer will answer all the questions received and participants will increase their knowledge thanks to the solutions discussed for everyone. The course will last two hours, from 09h00 to 11h00 - with open questions on the proposed topic at the end. “Office software Individual coaching”: If one or several particular topics cause you sleepless nights, you can get the help of our trainer who will come to your workplace for a multiple of 1-hour slots . All fields ...

  11. Restucturing the Project Work Format

    DEFF Research Database (Denmark)

    Dupont, Søren

    2015-01-01

    The chapter is based on an evaluation of a pedagogical experiment at Roskilde University, the Antology Experiment. The objective of the experiment was to develop and expand the framework for project work through the production of anthologies compiled collectively by a number of project groups....... The novel aspects of the Anthology Experiment were most notably its magnitude and complexity. In this experiment the groups were totalling some 50 students who were working together. The experiment used a well-known publishing format from research, namely the anthology form, which usually focuses...... on a specific research topic and includes contributions from various researchers. In the Anthology Experiment, the project groups could be viewed as ‘research units’ that produce the contributions to the anthology. The complexity of the experiment offered challenges, both for students and supervisors...

  12. Indian English Evolution and Focusing Visible Through Power Laws

    Directory of Open Access Journals (Sweden)

    Vineeta Chand

    2017-11-01

    Full Text Available New dialect emergence and focusing in language contact settings is difficult to capture and date in terms of global structural dialect stabilization. This paper explores whether diachronic power law frequency distributions can provide evidence of dialect evolution and new dialect focusing, by considering the quantitative frequency characteristics of three diachronic Indian English (IE corpora (1970s–2008. The results demonstrate that IE consistently follows power law frequency distributions and the corpora are each best fit by Mandelbrot’s Law. Diachronic changes in the constants are interpreted as evidence of lexical and syntactic collocational focusing within the process of new dialect formation. Evidence of new dialect focusing is also visible through apparent time comparison of spoken and written data. Age and gender-separated sub-corpora of the most recent corpus show minimal deviation, providing apparent time evidence for emerging IE dialect stability. From these findings, we extend the interpretation of diachronic changes in the β coefficient—as indicative of changes in the degree of synthetic/analytic structure—so that β is also sensitive to grammaticalization and changes in collocational patterns.

  13. Thermal self-focusing with multiple beams

    International Nuclear Information System (INIS)

    Craxton, R.S.; McCrory, R.L.

    1986-07-01

    Self-focusing in underdense plasmas in the presence of overlapping beams is of interest for multibeam laser-irradiation systems. The hydrodynamics/ray-tracing simulation code SAGE is used to model thermal self-focusing in two-dimensional line-focus geometry with beams incident obliquely at different angles. The conjecture that multiple overlapping beams may suppress self-focusing is investigated for parameters appropriate to reactor-sized targets; in particular, the dependence upon intensity, scale length and pulse width is examined. While the full problem is three-dimensional, insight may be gained from two-dimensional simulations

  14. Automatic focusing system of BSST in Antarctic

    Science.gov (United States)

    Tang, Peng-Yi; Liu, Jia-Jing; Zhang, Guang-yu; Wang, Jian

    2015-10-01

    Automatic focusing (AF) technology plays an important role in modern astronomical telescopes. Based on the focusing requirement of BSST (Bright Star Survey Telescope) in Antarctic, an AF system is set up. In this design, functions in OpenCV is used to find stars, the algorithm of area, HFD or FWHM are used to degree the focus metric by choosing. Curve fitting method is used to find focus position as the method of camera moving. All these design are suitable for unattended small telescope.

  15. Regulatory focus affects physician risk tolerance.

    Science.gov (United States)

    Veazie, Peter J; McIntosh, Scott; Chapman, Benjamin P; Dolan, James G

    2014-01-01

    Risk tolerance is a source of variation in physician decision-making. This variation, if independent of clinical concerns, can result in mistaken utilization of health services. To address such problems, it will be helpful to identify nonclinical factors of risk tolerance, particularly those amendable to intervention-regulatory focus theory suggests such a factor. This study tested whether regulatory focus affects risk tolerance among primary care physicians. Twenty-seven primary care physicians were assigned to promotion-focused or prevention-focused manipulations and compared on the Risk Taking Attitudes in Medical Decision Making scale using a randomization test. Results provide evidence that physicians assigned to the promotion-focus manipulation adopted an attitude of greater risk tolerance than the physicians assigned to the prevention-focused manipulation (p = 0.01). The Cohen's d statistic was conventionally large at 0.92. Results imply that situational regulatory focus in primary care physicians affects risk tolerance and may thereby be a nonclinical source of practice variation. Results also provide marginal evidence that chronic regulatory focus is associated with risk tolerance (p = 0.05), but the mechanism remains unclear. Research and intervention targeting physician risk tolerance may benefit by considering situational regulatory focus as an explanatory factor.

  16. FEMP Focus: 2011 Volume 20 Issue 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-04-05

    Department of Energy (DOE); Federal Energy Management Program; FEMP Focus Newsletter; December 2010; Alternative Financing, Guidance Documents, Recovery Act Technical Assistance, Training, Energy Awareness

  17. Tube Formation in Nanoscale Materials

    Directory of Open Access Journals (Sweden)

    Yan Chenglin

    2008-01-01

    Full Text Available Abstract The formation of tubular nanostructures normally requires layered, anisotropic, or pseudo-layered crystal structures, while inorganic compounds typically do not possess such structures, inorganic nanotubes thus have been a hot topic in the past decade. In this article, we review recent research activities on nanotubes fabrication and focus on three novel synthetic strategies for generating nanotubes from inorganic materials that do not have a layered structure. Specifically, thermal oxidation method based on gas–solid reaction to porous CuO nanotubes has been successfully established, semiconductor ZnS and Nb2O5nanotubes have been prepared by employing sacrificial template strategy based on liquid–solid reaction, and an in situ template method has been developed for the preparation of ZnO taper tubes through a chemical etching reaction. We have described the nanotube formation processes and illustrated the detailed key factors during their growth. The proposed mechanisms are presented for nanotube fabrication and the important pioneering studies are discussed on the rational design and fabrication of functional materials with tubular structures. It is the intention of this contribution to provide a brief account of these research activities.

  18. Using Focus Group Research in Public Relations.

    Science.gov (United States)

    Grunig, Larissa A.

    1990-01-01

    Analyzes a recent instance of focus group research applied to a public relations case (rather than a marketing case). Reviews the advantages and disadvantages of this qualitative method, and describes the case of a county department of mental health relying on focus group research to help plan a program aimed at reducing the stigma of mental…

  19. Identifying Information Focuses in Listening Comprehension

    Science.gov (United States)

    Zhang, Hong-yan

    2011-01-01

    The study explains the process of learners' listening comprehension within Halliday's information theory in functional grammar, including the skills of identifying focuses while listening in college English teaching. Identifying information focuses in listening is proved to improve the students' communicative listening ability by the means of a…

  20. Plasma lenses for focusing relativistic electron beams

    International Nuclear Information System (INIS)

    Govil, R.; Wheeler, S.; Leemans, W.

    1997-01-01

    The next generation of colliders require tightly focused beams with high luminosity. To focus charged particle beams for such applications, a plasma focusing scheme has been proposed. Plasma lenses can be overdense (plasma density, n p much greater than electron beam density, n b ) or underdense (n p less than 2 n b ). In overdense lenses the space-charge force of the electron beam is canceled by the plasma and the remaining magnetic force causes the electron beam to self-pinch. The focusing gradient is nonlinear, resulting in spherical aberrations. In underdense lenses, the self-forces of the electron beam cancel, allowing the plasma ions to focus the beam. Although for a given beam density, a uniform underdense lens produces smaller focusing gradients than an overdense lens, it produces better beam quality since the focusing is done by plasma ions. The underdense lens can be improved by tapering the density of the plasma for optimal focusing. The underdense lens performance can be enhanced further by producing adiabatic plasma lenses to avoid the Oide limit on spot size due to synchrotron radiation by the electron beam. The plasma lens experiment at the Beam Test Facility (BTF) is designed to study the properties of plasma lenses in both overdense and underdense regimes. In particular, important issues such as electron beam matching, time response of the lens, lens aberrations and shot-to-shot reproducibility are being investigated

  1. Renal tissue damage induced by focused shock waves

    Science.gov (United States)

    Ioritani, N.; Kuwahara, M.; Kambe, K.; Taguchi, K.; Saitoh, T.; Shirai, S.; Orikasa, S.; Takayama, K.; Lush, P. A.

    1990-07-01

    Biological evidence of renal arterial wall damage induced by the microjet due to shock wave-cavitation bubble interaction was demonstrated in living dog kidneys. We also intended to clarify the mechanism of renal tissue damage and the effects of different conditions of shock wave exposure (peak pressure of focused area, number of shots, exposure rate) on the renal tissue damage in comparison to stone disintegration. Disruption of arterial wall was the most remarkable histological change in the focused area of the kidneys. This lesion appeared as if the wall had been punctured by a needle. Large hematoma formation in the renal parenchym, and interstitial hemorrhage seemed to be the results of the arterial lesion. This arterial disorder also led to ischemic necrosis of the tubules surrounding the hematoma. Micro-angiographic examination of extracted kidneys also proved such arterial puncture lesions and ischemic lesions. The number of shots required for model stone disintegration was not inversely proportional to peak pressure. It decreased markedly when peak pressure was above 700 bar. Similarly thenumber of shots for hematoma formation was not inversely proportional to peak pressure, however, this decreased markedly above 500 bar. These results suggested that a hematoma could be formed under a lower peak pressure than that required for stone disintegration.

  2. Attentional Focusing Instructions and Force Production

    Directory of Open Access Journals (Sweden)

    David C Marchant

    2011-01-01

    Full Text Available Research progress assessing the role of attentional focusing instructions on skill acquisition and performance has lead researchers to apply this approach to force production tasks. Initial converging evidence indicates that force production tasks are sensitive to verbal instruction; externally focused instructions (onto movement outcomes, or onto the object force is being exerted against are shown to be more beneficial than internally focused instructions (focusing attention onto the movements being executed. These benefits are observed for maximal and accurate force production, as well as the maintenance of force production in prolonged tasks. A range of mechanisms are identified supporting the proposal that an external focus promotes movement efficiency in line with energy and effort conservation. Future research is required to assess how this developing body of work interacts with the broader understanding of psychological and physiological factors implicated in the effective production, maintenance and limitation of maximal or sub-maximal forces.

  3. Final focus systems for linear colliders

    International Nuclear Information System (INIS)

    Erickson, R.A.

    1987-11-01

    The final focus system of a linear collider must perform two primary functions, it must focus the two opposing beams so that their transverse dimensions at the interaction point are small enough to yield acceptable luminosity, and it must steer the beams together to maintain collisions. In addition, the final focus system must transport the outgoing beams to a location where they can be recycled or safely dumped. Elementary optical considerations for linear collider final focus systems are discussed, followed by chromatic aberrations. The design of the final focus system of the SLAC Linear Collider (SLC) is described. Tuning and diagnostics and steering to collision are discussed. Most of the examples illustrating the concepts covered are drawn from the SLC, but the principles and conclusions are said to be generally applicable to other linear collider designs as well. 26 refs., 17 figs

  4. Blistering and bubble formation

    International Nuclear Information System (INIS)

    Roth, J.

    1976-01-01

    Blister formation in metals has been observed during bombardment with inert-gas ions in the energy range between 1 and 2000 keV at doses of about 10 17 to 10 19 cm -2 . The changes in surface topography and the erosion yields were mainly studied in the scanning electron microscope (SEM). Additionally the release of the implanted gas during blister formation was observed. Recently measurements on single crystals were performed determining simultaneously the implantation profile, the total amount of trapped ions, the depth distribution of the induced lattice damage and the thickness of the covers of the blisters. In several stages of the formation process of blisters the implanted layer was observed in the transmission electron microscope (TEM) showing the formation of gas bubbles. Using the results of all these measurements in this review an attempt is made to develop a model of blister formation combining the effects of hydrostatic pressure in the gas bubbles and lateral stress due to volume swelling. (author)

  5. Vascular lumen formation.

    Science.gov (United States)

    Lammert, Eckhard; Axnick, Jennifer

    2012-04-01

    The vascular system developed early in evolution. It is required in large multicellular organisms for the transport of nutrients, oxygen, and waste products to and from tissues. The vascular system is composed of hollow tubes, which have a high level of complexity in vertebrates. Vasculogenesis describes the de novo formation of blood vessels, e.g., aorta formation in vertebrate embryogenesis. In contrast, angiogenesis is the formation of blood vessels from preexisting ones, e.g., sprouting of intersomitic blood vessels from the aorta. Importantly, the lumen of all blood vessels in vertebrates is lined and formed by endothelial cells. In both vasculogenesis and angiogenesis, lumen formation takes place in a cord of endothelial cells. It involves a complex molecular mechanism composed of endothelial cell repulsion at the cell-cell contacts within the endothelial cell cords, junctional rearrangement, and endothelial cell shape change. As the vascular system also participates in the course of many diseases, such as cancer, stroke, and myocardial infarction, it is important to understand and make use of the molecular mechanisms of blood vessel formation to better understand and manipulate the pathomechanisms involved.

  6. EDITORIAL: Focus on Heart and Mind

    Science.gov (United States)

    Bodenschatz, Eberhard; Wolf, Fred

    2008-01-01

    Among the organs of our body, the function of heart and brain are unique in that their operation emerges from the collective dynamics of millions of strongly interacting cells well organized in their geometrical structure and connectivity. In the heart muscle the propagation of a nonlinear wave pulse, the cardiac action potential, controls the contraction. Usually the propagation is well-organized both in space and time and the heart functions as an efficient biological pump. Instabilities triggered by diseased tissue but also by dynamical heterogeneities, may, however, induce cardiac arrhythmia and fibrillation, where the pacemaker looses control to dynamically generated, high-frequency self-excitation of the muscle. In this state the coherence of contraction is lost and may lead within minutes to death. The appearance of arrhythmias can be associated with topological singularities, the so called spiral or scroll waves, and how the occurrence of this malfunctioning pattern-formation process can be understood is a dominant subject of current research. This is all the more important as cardiac arrhythmias and fibrillation are the main cause of premature death in the developed world. Similarly, in the brain the propagation of a nonlinear wave pulse, namely the neural action potential, is at the basis of the computational and memory power of the brain, i.e. what determines the workings of our 'minds'. Here, however, due to the high degree of interconnectivity and topological complexity of the neuronal network, the coordinated activity of millions of interacting nerve cells is more complex, although the basic principles of action potential generation at the level of each cell are quite similar. The currently emerging field of network dynamical systems is largely driven by the mathematical challenge and the steady stream of novel dynamical phenomena that results from the interplay of local nonlinear dynamics and complex network structure in models of biological neuronal

  7. Meningococcal biofilm formation

    DEFF Research Database (Denmark)

    Lappann, M.; Haagensen, Janus Anders Juul; Claus, H.

    2006-01-01

    We show that in a standardized in vitro flow system unencapsulated variants of genetically diverse lineages of Neisseria meningitidis formed biofilms, that could be maintained for more than 96 h. Biofilm cells were resistant to penicillin, but not to rifampin or ciprofloxacin. For some strains......, microcolony formation within biofilms was observed. Microcolony formation in strain MC58 depended on a functional copy of the pilE gene encoding the pilus subunit pilin, and was associated with twitching of cells. Nevertheless, unpiliated pilE mutants formed biofilms showing that attachment and accumulation......X alleles was identified among genetically diverse meningococcal strains. PilX alleles differed in their propensity to support autoaggregation of cells in suspension, but not in their ability to support microcolony formation within biofilms in the continuous flow system....

  8. Tritiated ammonia formation

    International Nuclear Information System (INIS)

    Heung, L.K.

    1995-01-01

    When nitrogen was selected as the glovebox atmosphere for the Replacement Tritium Facility (RTF) at the Savannah River Site (SRS), a concern was raised as to the possibility of tritiated ammonia formation in the gloveboxes. Experimental data were produced to study the tritiated ammonia formation rate in a tritium and nitrogen mixture. A rate equation that closely simulates the experimental data was developed. This rate equation can be used to calculate the formation of tritiated ammonia from different concentrations of tritium and nitrogen. The reaction of T 2 and N 2 to form NT 3 is a slow process, particularly when the tritium concentration is low. The reaction requires weeks or months to reach radiochemical equilibrium dependent on the concentrations of the reactants. 4 refs., 6 figs., 1 tab

  9. Galaxy formation and evolution

    CERN Document Server

    Mo, Houjun; White, Simon

    2010-01-01

    The rapidly expanding field of galaxy formation lies at the interface between astronomy, particle physics, and cosmology. Covering diverse topics from these disciplines, all of which are needed to understand how galaxies form and evolve, this book is ideal for researchers entering the field. Individual chapters explore the evolution of the Universe as a whole and its particle and radiation content; linear and nonlinear growth of cosmic structure; processes affecting the gaseous and dark matter components of galaxies and their stellar populations; the formation of spiral and elliptical galaxies; central supermassive black holes and the activity associated with them; galaxy interactions; and the intergalactic medium. Emphasizing both observational and theoretical aspects, this book provides a coherent introduction for astronomers, cosmologists, and astroparticle physicists to the broad range of science underlying the formation and evolution of galaxies.

  10. Observsational Planet Formation

    Science.gov (United States)

    Dong, Ruobing; Zhu, Zhaohuan; Fung, Jeffrey

    2017-06-01

    Planets form in gaseous protoplanetary disks surrounding newborn stars. As such, the most direct way to learn how they form from observations, is to directly watch them forming in disks. In the past, this was very difficult due to a lack of observational capabilities; as such, planet formation was largely a subject of pure theoretical astrophysics. Now, thanks to a fleet of new instruments with unprecedented resolving power that have come online recently, we have just started to unveil features in resolve images of protoplanetary disks, such as gaps and spiral arms, that are most likely associated with embedded (unseen) planets. By comparing observations with theoretical models of planet-disk interactions, the masses and orbits of these still forming planets may be constrained. Such planets may help us to directly test various planet formation models. This marks the onset of a new field — observational planet formation. I will introduce the current status of this field.

  11. Forces in strategy formation

    DEFF Research Database (Denmark)

    Steensen, Elmer Fly; Sanchez, Ron

    2008-01-01

    This chapter proposes that organizational strategy formation should be characterized theoretically as a process that is subject to several interacting forces, rather than represented by separate discrete decisionmodels or theoretic perspectives, as is commonly done in the strategic management...... literature. Based on an extensive review of relevant theory and empirical work in strategic decision-making, organizational change theory, cognitive and social psychology, and strategy processes, seven kinds of ''forces'' - rational, imposed, teleological, learning, political, heuristic, and social...... - are identified as interacting in and having significant influence on the strategy formation process. It is further argued that by applying a holistic ''forces-view'' of the significant and interacting influences on strategy formation, we can better understand the dynamics and challenges in managing the process...

  12. Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction.

    Science.gov (United States)

    Dhamad, Ahmed E; Zhou, Zhenqi; Zhou, Jianhong; Du, Yuchun

    2016-01-01

    Heat shock proteins (Hsps) are known to associate with estrogen receptors (ER) and regulate ER-mediated cell proliferation. Historically, the studies in this area have focused on Hsp90. However, some critical aspects of the Hsp-ERα interactions remain unclear. For example, we do not know which Hsps are the major or minor ERα interactants and whether or not different Hsp isoforms associate equally with ERα. In the present study, through a quantitative proteomic method we found that 21 Hsps and 3 Hsp cochaperones were associated with ERα in human 293T cells that were cultured in a medium containing necessary elements for cell proliferation. Four Hsp70s (Hsp70-1, Hsc70, Grp75, and Grp78) were the most abundant Hsps identified to associate with ERα, followed by two Hsp90s (Hsp90α and Hsp90β) and three Hsp110s (Hsp105, HspA4, and HspA4L). Hsp90α was found to be 2-3 times more abundant than Hsp90β in the ERα-containing complexes. Among the reported Hsp cochaperones, we detected prostaglandin E synthase 3 (p23), peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP51), and E3 ubiquitin-protein ligase CHIP (CHIP). Studies with the two most abundant ERα-associated Hsps, Hsp70-1 and Hsc70, using human breast cancer MCF7 cells demonstrate that the two Hsps interacted with ERα in both the cytoplasm and nucleus when the cells were cultured in a medium supplemented with fetal bovine serum and phenol red. Interestingly, the ERα-Hsp70-1/Hsc70 interactions were detected only in the cytoplasm but not in the nucleus under hormone starvation conditions, and stimulation of the starved cells with 17β-estradiol (E2) did not change this. In addition, E2-treatment weakened the ERα-Hsc70 interaction but had no effect on the ERα-Hsp70-1 interaction. Further studies showed that significant portions of Hsp70-1 and Hsc70 were associated with transcriptionally active chromatin and inactive chromatin, and the two Hsps interacted with ERα in both forms of the chromatins in MCF7 cells.

  13. Deep learning for SAR image formation

    Science.gov (United States)

    Mason, Eric; Yonel, Bariscan; Yazici, Birsen

    2017-04-01

    The recent success of deep learning has lead to growing interest in applying these methods to signal processing problems. This paper explores the applications of deep learning to synthetic aperture radar (SAR) image formation. We review deep learning from a perspective relevant to SAR image formation. Our objective is to address SAR image formation in the presence of uncertainties in the SAR forward model. We present a recurrent auto-encoder network architecture based on the iterative shrinkage thresholding algorithm (ISTA) that incorporates SAR modeling. We then present an off-line training method using stochastic gradient descent and discuss the challenges and key steps of learning. Lastly, we show experimentally that our method can be used to form focused images in the presence of phase uncertainties. We demonstrate that the resulting algorithm has faster convergence and decreased reconstruction error than that of ISTA.

  14. Tanks Focus Area annual report FY2000

    International Nuclear Information System (INIS)

    2000-01-01

    The U.S. Department of Energy (DOE) continues to face a major radioactive waste tank remediation effort with tanks containing hazardous and radioactive waste resulting from the production of nuclear materials. With some 90 million gallons of waste in the form of solid, sludge, liquid, and gas stored in 287 tanks across the DOE complex, containing approximately 650 million curies, radioactive waste storage tank remediation is the nation's highest cleanup priority. Differing waste types and unique technical issues require specialized science and technology to achieve tank cleanup in an environmentally acceptable manner. Some of the waste has been stored for over 50 years in tanks that have exceeded their design lives. The challenge is to characterize and maintain these contents in a safe condition and continue to remediate and close each tank to minimize the risks of waste migration and exposure to workers, the public, and the environment. In 1994, the DOE's Office of Environmental Management (EM) created a group of integrated, multiorganizational teams focusing on specific areas of the EM cleanup mission. These teams have evolved into five focus areas managed within EM's Office of Science and Technology (OST): Tanks Focus Area (TFA); Deactivation and Decommissioning Focus Area; Nuclear Materials Focus Area; Subsurface Contaminants Focus Area; and Transuranic and Mixed Waste Focus Area

  15. Tanks Focus Area annual report FY2000

    Energy Technology Data Exchange (ETDEWEB)

    None

    2000-12-01

    The U.S. Department of Energy (DOE) continues to face a major radioactive waste tank remediation effort with tanks containing hazardous and radioactive waste resulting from the production of nuclear materials. With some 90 million gallons of waste in the form of solid, sludge, liquid, and gas stored in 287 tanks across the DOE complex, containing approximately 650 million curies, radioactive waste storage tank remediation is the nation's highest cleanup priority. Differing waste types and unique technical issues require specialized science and technology to achieve tank cleanup in an environmentally acceptable manner. Some of the waste has been stored for over 50 years in tanks that have exceeded their design lives. The challenge is to characterize and maintain these contents in a safe condition and continue to remediate and close each tank to minimize the risks of waste migration and exposure to workers, the public, and the environment. In 1994, the DOE's Office of Environmental Management (EM) created a group of integrated, multiorganizational teams focusing on specific areas of the EM cleanup mission. These teams have evolved into five focus areas managed within EM's Office of Science and Technology (OST): Tanks Focus Area (TFA); Deactivation and Decommissioning Focus Area; Nuclear Materials Focus Area; Subsurface Contaminants Focus Area; and Transuranic and Mixed Waste Focus Area.

  16. Deep-Focusing Time-Distance Helioseismology

    Science.gov (United States)

    Duvall, T. L., Jr.; Jensen, J. M.; Kosovichev, A. G.; Birch, A. C.; Fisher, Richard R. (Technical Monitor)

    2001-01-01

    Much progress has been made by measuring the travel times of solar acoustic waves from a central surface location to points at equal arc distance away. Depth information is obtained from the range of arc distances examined, with the larger distances revealing the deeper layers. This method we will call surface-focusing, as the common point, or focus, is at the surface. To obtain a clearer picture of the subsurface region, it would, no doubt, be better to focus on points below the surface. Our first attempt to do this used the ray theory to pick surface location pairs that would focus on a particular subsurface point. This is not the ideal procedure, as Born approximation kernels suggest that this focus should have zero sensitivity to sound speed inhomogeneities. However, the sensitivity is concentrated below the surface in a much better way than the old surface-focusing method, and so we expect the deep-focusing method to be more sensitive. A large sunspot group was studied by both methods. Inversions based on both methods will be compared.

  17. Planetesimals and Planet Formation

    Science.gov (United States)

    Chambers, John

    The first step in the standard model for planet formation is the growth of gravitationally bound bodies called ``planetesimals'' from dust grains in a protoplanetary disk. Currently, we do not know how planetesimals form, how long they take to form, or what their sizes and mechanical properties are. The goal of this proposal is to assess how these uncertainties affect subsequent stages of planetary growth and the kind of planetary systems that form. The work will address three particular questions: (i) Can the properties of small body populations in the modern Solar System constrain the properties of planetesimals? (ii) How do the properties of planetesimals affect the formation of giant planets? (iii) How does the presence of a water ice condensation front (the ``snow line'') in a disk affect planetesimal formation and the later stages of planetary growth? These questions will be examined with computer simulations of planet formation using new computer codes to be developed as part of the proposal. The first question will be addressed using a statistical model for planetesimal coagulation and fragmentation. This code will be merged with the proposer's Mercury N-body integrator code to model the dynamics of large protoplanets in order to address the second question. Finally, a self- consistent model of disk evolution and the radial transport of water ice and vapour will be added to examine the third question. A theoretical understanding of how planets form is one of the key goals of NASA and the Origins of Solar Systems programme. Researchers have carried out many studies designed to address this goal, but the questions of how planetesimals form and how their properties affect planet formation have received relatively little attention. The proposed work will help address these unsolved questions, and place other research in context by assessing the importance of planetesimal origins and properties for planet formation.

  18. Analysis of behavior of focusing error signals generated by astigmatic method when a focused spot moves beyond the radius of a land-groove-type optical disk

    Science.gov (United States)

    Shinoda, Masahisa; Nakatani, Hidehiko; Nakai, Kenya; Ohmaki, Masayuki

    2015-09-01

    We theoretically calculate behaviors of focusing error signals generated by an astigmatic method in a land-groove-type optical disk. The focusing error signal from the land does not coincide with that from the groove. This behavior is enhanced when a focused spot of an optical pickup moves beyond the radius of the optical disk. A gain difference between the slope sensitivities of focusing error signals from the land and the groove is an important factor with respect to stable focusing servo control. In our calculation, the format of digital versatile disc-random access memory (DVD-RAM) is adopted as the land-groove-type optical disk model, and the dependences of the gain difference on various factors are investigated. The gain difference strongly depends on the optical intensity distribution of the laser beam in the optical pickup. The calculation method and results in this paper will be reflected in newly developed land-groove-type optical disks.

  19. Superclusters and galaxy formation

    International Nuclear Information System (INIS)

    Einasto, J.; Joeveer, M.; Saar, E.

    1979-01-01

    The spatial distribution of Galaxies and Galaxy congestions in the southern galactic hemisphere is studied. The rich galaxy congestions, containing many elliptic Galaxies and radiogalaxies, are linked with each other by chains of scanty congestions with moderate content of elliptic Galaxies and radiogalaxies. The flat formation, linking the density pikes and the intermediate chains, can reasonably be called supercongestion. In the central region of supercongestions there is a thin layer of Galaxies consisting of only spiral Galaxies. The neighbouring supercongestions touch each other, while the intersupercongestion space contains no Galaxy congestions and almost no Galaxies. It is shown that such a structure was, apparently, formed before the formation of Galaxies

  20. Formation of galaxies

    International Nuclear Information System (INIS)

    Szalay, A.S.

    1984-12-01

    The present theories of galaxy formation are reviewed. The relation between peculiar velocities and the correlation function of galaxies points to the possibility that galaxies do not form uniformly everywhere. Scale invariant properties of the cluster-cluster correlations are discussed. Comparing the correlation functions in a dimensionless way, galaxies appear to be stronger clustered, in contrast with the comparison of the dimensional amplitudes of the correlation functions. Theoretical implications of several observations as Lyman-α clouds, correlations of faint galaxies are discussed. None of the present theories of galaxy formation can account for all facts in a natural way. 29 references

  1. The formation of stars

    CERN Document Server

    Stahler, Steven W

    2008-01-01

    This book is a comprehensive treatment of star formation, one of the most active fields of modern astronomy. The reader is guided through the subject in a logically compelling manner. Starting from a general description of stars and interstellar clouds, the authors delineate the earliest phases of stellar evolution. They discuss formation activity not only in the Milky Way, but also in other galaxies, both now and in the remote past. Theory and observation are thoroughly integrated, with the aid of numerous figures and images. In summary, this volume is an invaluable resource, both as a text f

  2. Open-access publishing for pharmacy-focused journals.

    Science.gov (United States)

    Clauson, Kevin A; Veronin, Michael A; Khanfar, Nile M; Lou, Jennie Q

    2008-08-15

    Pharmacy-focused journals that are available in open-access (OA), freely accessible, hybrid, or traditional formats were identified. Relevant journals were accessed from PubMed, International Pharmaceutical Abstracts, EMBASE, and the Pharmacology and Pharmacy category of Thomson Scientific Journal Citation Reports. Criteria were established to select journals that satisfied the definition of pharmacy focused. Journals were assessed based on accessibility, copyright transfer requirements, and restrictions. If tracked, the journal's impact factor (IF) was identified according to classification, and medians were calculated for each journal category. A total of 317 pharmacy-focused journals were identified. The majority of pharmacy-focused journals identified were traditional/non-OA (n = 240). A smaller number of journals were freely accessible/ non-OA (n = 37), freely accessible/non-OA with content restrictions (n = 20), or freely available/non-OA with date restrictions (n = 18). The fewest number of journals were completely OA (n = 2). The median IF for the 185 journals whose IF was tracked was 2.029. The median IF for freely accessible and hybrid journals (n = 42) was 2.550, whereas the median IF for traditional journals (n = 143) was 1.900. A very small number of pharmacy-focused journals adhere to the OA paradigm of access. However, journals that adopt some elements of the OA model, chiefly free accessibility, may be more likely to be cited than traditional journals. Pharmacy practitioners, educators, and researchers could benefit from the advantages that OA offers but should understand its financial disadvantages.

  3. Densities and Kinematic Viscosities for the Systems Benzene + Methyl Formate, Benzene + Ethyl Formate, Benzene + Propyl Formate, and Benzene + Butyl Formate

    DEFF Research Database (Denmark)

    Emmerling, Uwe; Rasmussen, Peter

    1998-01-01

    a Redlich-Kister type of expression with temperature-independent parameters and the data for the systems benzene + ethyl formate, benzene + propyl formate, and benzene + butyl formate with temperature-dependent parameters. The viscosities have furthermore been compared to values predicted by means of the GC......Densities and kinematic viscosities have been measured for the system benzene + methyl formate at 20°C and for the systems benzene + ethyl formate, benzene + propyl formate, and benzene + butyl formate from 20°C to 50°C. The results for the system benzene + methyl formate have been correlated using...

  4. High-intensity focused ultrasound ablation around the tubing.

    Science.gov (United States)

    Siu, Jun Yang; Liu, Chenhui; Zhou, Yufeng

    2017-01-01

    High-intensity focused ultrasound (HIFU) has been emerging as an effective and noninvasive modality in cancer treatment with very promising clinical results. However, a small vessel in the focal region could be ruptured, which is an important concern for the safety of HIFU ablation. In this study, lesion formation in the polyacrylamide gel phantom embedded with different tubing (inner diameters of 0.76 mm and 3 mm) at varied flow speeds (17-339 cm/s) by HIFU ablation was photographically recorded. Produced lesions have decreased length (~30%) but slightly increased width (~6%) in comparison to that without the embedded tubing. Meanwhile, bubble activities during the exposures were measured by passive cavitation detection (PCD) at the varied pulse repetition frequency (PRF, 10-30 Hz) and duty cycle (DC, 10%-20%) of the HIFU bursts. High DC and low flow speed were found to produce stronger bubble cavitation whereas no significant influence of the PRF. In addition, high-speed photography illustrated that the rupture of tubing was produced consistently after the first HIFU burst within 20 ms and then multiple bubbles would penetrate into the intraluminal space of tubing through the rupture site by the acoustic radiation force. Alignment of HIFU focus to the anterior surface, middle, and posterior surface of tubing led to different characteristics of vessel rupture and bubble introduction. In summary, HIFU-induced vessel rupture is possible as shown in this phantom study; produced lesion sizes and shapes are dependent on the focus alignment to the tubing, flow speed, and tubing properties; and bubble cavitation and the formation liquid jet may be one of the major mechanisms of tubing rupture as shown in the high-speed photography.

  5. Technology of a small plasma focus

    International Nuclear Information System (INIS)

    Lee, S.

    1990-01-01

    This paper reviews plasma focus technology, including the underlying dynamic and energy balance theory, scaling of the neutron yield, cost effectiveness of the design, as well as the main subsystems, e.g., capacitor bank, spark-gap switch and triggering electronics, the plasma focus tube, some simple diagnostics, and a high-voltage charger. It discusses the range of densities and temperatures available with a small plasma focus, and the type of experiments and applications that can be carried out with it. 61 refs, 21 figs

  6. Designing focusing solenoids for superconducting RF accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Davis, G.; Kashikhin, V.V.; Page, T.; Terechkine, I.; Tompkins, J.; Wokas, T.; /Fermilab

    2006-08-01

    The design of a focusing solenoid for use in a superconducting RF linac requires resolving a range of problems with conflicting requirements. Providing the required focusing strength contradicts the goal of minimizing the stray field on the surfaces of adjacent superconducting RF cavities. The requirement of a compact solenoid, able to fit into a gap between cavities, contradicts the need of mechanical support necessary to restrain electromagnetic forces that can result in coil motion and subsequent quenching. In this report we will attempt to address these and other issues arising during the development of focusing solenoids. Some relevant test data will also be presented.

  7. The problem of focusing and real images

    International Nuclear Information System (INIS)

    Mihas, Pavlos

    2008-01-01

    A historical discussion of the theories which deal with the formation of real images in mirrors and lenses is presented in this paper. Speculations on mirrors appeared as early as Plato. Euclid's, Hero's and Ptolemy's approaches to visual rays are described. The theory on burning mirrors starts with Diocles and later was continued by the Arabs. Al Haytham extensively studied the reflection of light rays on concave mirrors. Huygens tried to find a shorter way to do the calculations. With lenses Kepler gave a new way of finding the position of images by using approximations. Huygens also gave a solution for the shape of a 'perfect' lens. Huygens' principle on waves can be combined with Fermat's principle to explain the formation of images. These theories can be used in education to help students better understand the formation of images, the propagation of waves and the properties of lenses

  8. Applications of focused ion beams in microelectronics

    International Nuclear Information System (INIS)

    Broughton, C.; Beale, M.I.J.; Deshmukh, V.G.I.

    1986-04-01

    We present the conclusions of the RSRE programme on the application of focused ion beams in microelectronics and review the literature published in this field. We discuss the design and performance of focused beam implanters and the viability of their application to semiconductor device fabrication. Applications in the areas of lithography, direct implantation and micromachining are discussed in detail. Comparisons are made between the use of focused ion beams and existing techniques for these fabrication processes with a strong emphasis placed on the relative throughputs. We present results on a novel spot size measurement technique and the effect of beam heating on resist. We also present the results of studies into implantation passivation of resist to oxygen plasma attack as basis for a dry development lithography scheme. A novel lithography system employing flood electron exposure from a photocathode which is patterned by a focused ion beam which can also be used to repair mask defects is considered. (author)

  9. Focus Cities : Reducing the Vulnerability, Poverty and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Focus Cities : Reducing the Vulnerability, Poverty and Environmental Load in ... 000 lives in closely constructed houses built right up to the edge of the Rimac River. ... and the Lima Metropolitan Urban Plan will be updated in light of the results.

  10. Focusing on ADHD - Attention Deficit Hyperactivity Disorder

    Science.gov (United States)

    ... September 2014 Print this issue Focusing on ADHD Attention Deficit Hyperactivity Disorder En español Send us your comments ... might be signs of a developmental disorder called attention deficit hyperactivity disorder, or ADHD. ADHD is a common ...

  11. Spatial filters for focusing ultrasound images

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Gori, Paola

    2001-01-01

    , but the approach always yields point spread functions better or equal to a traditional dynamically focused image. Finally, the process was applied to in-vivo clinical images of the liver and right kidney from a 28 years old male. The data was obtained with a single element transducer focused at 100 mm....... A new method for making spatial matched filter focusing of RF ultrasound data is proposed based on the spatial impulse response description of the imaging. The response from a scatterer at any given point in space relative to the transducer can be calculated, and this gives the spatial matched filter...... for synthetic aperture imaging for single element transducers. It is evaluated using the Field II program. Data from a single 3 MHz transducer focused at a distance of 80 mm is processed. Far from the transducer focal region, the processing greatly improves the image resolution: the lateral slice...

  12. Structural Analysis of Extended Plasma Focus Chamber

    International Nuclear Information System (INIS)

    Mohd Azhar Ahmad; Abdul Halim Baijan; Siti Aiasah Hashim

    2016-01-01

    Accelerator Development Centre (ADC) of Nuclear Malaysia intends to upgrade the plasma focus device. It involves the extension part placed on top of the existing plasma focus vacuum chamber. This extended vacuum chamber purposely to give an extra space in conducting experiments on the existing plasma focus chamber. The aim of upgrading the plasma focus device is to solve the limitation in research and analysis of sample due to its done in an open system that cause analysis of samples is limited and less optimal. This extended chamber was design in considering the ease of fabrication as well as durability of its structural. Thus, this paper discusses the structural analysis in term of pressure loading effect in extended chamber. (author)

  13. Symmetric lens with extended depth of focus

    OpenAIRE

    Cho, Sung Nae

    2008-01-01

    The lens surface profile is derived based on the instantaneous focal length versus the lens radius data. The lens design based on instantaneous focal length versus the lens radius data has many useful applications in software assisted image focusing technology.

  14. Social Work Intervention Focused on Transitions

    Science.gov (United States)

    2016-12-19

    Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention; Heart Disease; Diabetes; Hypertension; Cancer; Depression; Asthma; Chronic Heart Failure; Chronic Obstructive Pulmonary Disease; Stroke

  15. Nonverbal communication in the focus-group

    Directory of Open Access Journals (Sweden)

    Alina Simona TECĂU

    2015-12-01

    Full Text Available In the process of analysing the information obtained through focus group qualitative marketing research, a very important source of data is represented by non-verbal communication. Although the literature reveals an abundance of published material that describes how data obtained through focus group should be analysed, one of the least addressed issue is the interpretation of signals from participants: gestures, posture, dynamic and rhythm of speech or even the silence. This Article addresses precisely aspects of non-verbal communication in the focus group's and although not intended to examine in detail the results of a focus group, it shows how some of signals transmitted by participants of such research have been analysed and interpreted.

  16. Niger institute focuses on financial accountability | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-04-28

    Apr 28, 2016 ... Niger institute focuses on financial accountability ... on renewing outdated financial management systems that impeded effective management and reporting on its activities. ... Canada-Africa grants spur novel ideas, networks.

  17. Plasma focus as a pulsed power source

    International Nuclear Information System (INIS)

    Sahlin, H.; McFarland, G.; Barlett, R.; Gullickson, R.

    1975-01-01

    The plasma focus is a remarkable natural phenomena that achieves significant space-time compression of both particle and field energy. Depending on the mode of operation, about 20 percent of the bank energy can be concentrated into the kinetic energy of a thin, dense, cylindrically convergent gas shell, or into a small-diameter, high-ν/γ relativistic electron burst and oppositely directed ion burst. The kinetic energy of the fast ions and electrons can exceed the applied voltage by a factor of greater than 100. The different modes of energy concentration by the plasma focus are presented and discussed both in terms of their role in the direct yield of the focus and for the case of a plasma focus supplemented by various fusionable targets

  18. Focused labeled proof systems for modal logic

    OpenAIRE

    Miller , Dale; Volpe , Marco

    2015-01-01

    International audience; Focused proofs are sequent calculus proofs that group inference rules into alternating positive and negative phases. These phases can then be used to define macro-level inference rules from Gentzen's original and tiny introduction and structural rules. We show here that the inference rules of labeled proof systems for modal logics can similarly be described as pairs of such phases within the LKF focused proof system for first-order classical logic. We consider the syst...

  19. Superconducting quadrupoles for the SLC final focus

    International Nuclear Information System (INIS)

    Erickson, R.; Fieguth, T.; Murray, J.J.

    1987-01-01

    The final focus system of the SLC will be upgraded by replacing the final quadrupoles with higher gradient superconducting magnets positioned closer to the interaction point. The parameters of the new system have been chosen to be compatible with the experimental detectors with a minimum of changes to other final focus components. These parameter choices are discussed along with the expected improvement in SLC performance

  20. Superconducting quadrupoles for the SLC final focus

    International Nuclear Information System (INIS)

    Erickson, R.; Fieguth, T.; Murray, J.J.

    1987-01-01

    The final focus system of the SLC will be upgraded by replacing the final quadrupoles with higher gradient supperconducting magnets positioned closer to the interaction point. The parameters of the new system have been chosen to be compatible with the experimental detectors with a minimum of changes to other final focus components. These parameter choices are discussed along with the expected improvement in SLC performance

  1. The final focus test beam project

    International Nuclear Information System (INIS)

    Burke, D.

    1991-05-01

    An overview is given of the Final Focus Test Beam (FFTB) that is being constructed as a prototype final focus system for a future electron-positron linear collider. This beam line will use as input the 50 GeV electron beam from the SLC linac, and is designed to reduce the transverse dimensions of the beam spot at the focal point to 1 μm. 5 refs., 2 figs., 1 tab

  2. Draft of textbook focused on indirect taxes

    OpenAIRE

    Nováková, Hana

    2012-01-01

    The diploma thesis is about draft of textbook which is focused on indirect taxes for business school. The thesis is divided into theoretical and practical part. The theoretical part is focused on teaching tax issues at business school. Readers are introduced with basic studying documents, for example framework educational program and school educational program. In the following part I have conducted didactic analysis of curriculum and textbook of economics for business schools. The draft of t...

  3. Barrier cell sheath formation

    International Nuclear Information System (INIS)

    Kesner, J.

    1980-04-01

    The solution for electrostatic potential within a simply modeled tandem mirror thermal barrier is seen to exhibit a sheath at each edge of the cell. The formation of the sheath requires ion collisionality and the analysis assmes that the collisional trapping rate into the barrier is considerably slower than the barrier pump rate

  4. Formation of topological defects

    International Nuclear Information System (INIS)

    Vachaspati, T.

    1991-01-01

    We consider the formation of point and line topological defects (monopoles and strings) from a general point of view by allowing the probability of formation of a defect to vary. To investigate the statistical properties of the defects at formation we give qualitative arguments that are independent of any particular model in which such defects occur. These arguments are substantiated by numerical results in the case of strings and for monopoles in two dimensions. We find that the network of strings at formation undergoes a transition at a certain critical density below which there are no infinite strings and the closed-string (loop) distribution is exponentially suppressed at large lengths. The results are contrasted with the results of statistical arguments applied to a box of strings in dynamical equilibrium. We argue that if point defects were to form with smaller probability, the distance between monopoles and antimonopoles would decrease while the monopole-to-monopole distance would increase. We find that monopoles are always paired with antimonopoles but the pairing becomes clean only when the number density of defects is small. A similar reasoning would also apply to other defects

  5. The formation of galaxies

    International Nuclear Information System (INIS)

    Gunn, J.E.

    1983-01-01

    The presently fashionable ideas for galaxy formation are reviewed briefly, and it is concluded that the standard isothermal heirarchy fits the available data best. A simple infall picture is presented which explains many of the observed properties of disk galaxies. (orig.)

  6. Chlorination and chloramines formation

    International Nuclear Information System (INIS)

    Yee, Lim Fang; Mohd Pauzi Abdullah; Sadia Ata; Abbas Abdullah; Basar IShak; Khairul Nidzham

    2008-01-01

    Chlorination is the most important method of disinfection in Malaysia which aims at ensuring an acceptable and safe drinking water quality. The dosing of chlorine to surface water containing ammonia and nitrogen compounds may form chloramines in the treated water. During this reaction, inorganic and organic chloramines are formed. The recommended maximum acceptable concentration (MAC) for chloramines in drinking water is 3000 μg/L. The production of monochloramine, dichloramine and trichloramine is highly dependent upon pH, contact time and the chlorine to ammonia molar ratio. The purpose of this study is to examine the formation of chloramines that occur upon the chlorination during the treatment process. Chloramines were determined using the N,N-diethyl-p-phenylenediamine (DPD) colorimetric method. The influences of ammonia, pH and chlorine dosage on the chloramines formation were also studied. This paper presents a modeling approach based on regression analysis which is designed to estimate the formation of chloramines. The correlation between the concentration of chloramines and the ammonia, pH and chlorine dosage was examined. In all cases, the quantity of chloramines formed depended linearly upon the amount of chlorine dosage. On the basis of this study it reveals that the concentration of chloramines is a function of chlorine dosage and the ammonia concentration to the chlorination process. PH seems to not significantly affect the formation of chloramines. (author)

  7. Temperature controlled 'void' formation

    International Nuclear Information System (INIS)

    Dasgupta, P.; Sharma, B.D.

    1975-01-01

    The nucleation and growth of voids in structural materials during high temperature deformation or irradiation is essentially dependent upon the existence of 'vacancy supersaturation'. The role of temperature dependent diffusion processes in 'void' formation under varying conditions, and the mechanical property changes associated with this microstructure are briefly reviewed. (author)

  8. Triggered star formation

    Czech Academy of Sciences Publication Activity Database

    Palouš, Jan; Ehlerová, Soňa

    2002-01-01

    Roč. 12, - (2002), s. 35-36 ISSN 1405-2059 R&D Projects: GA AV ČR IAA3003705; GA AV ČR KSK1048102 Institutional research plan: CEZ:AV0Z1003909 Keywords : interstellar medium * star formation * HI shells Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

  9. Syntactic Formats for Free

    DEFF Research Database (Denmark)

    Klin, Bartek; Sobocinski, Pawel

    2003-01-01

    A framework of Plotkin and Turi’s, originally aimed at providing an abstract notion of bi-simulation, is modified to cover other operational equivalences and preorders. Combined with bi-algebraic methods, it yields a technique for the derivation of syntactic formats for transition system specific...

  10. Formation of double layers

    International Nuclear Information System (INIS)

    Leung, P.; Wong, A.Y.; Quon, B.H.

    1981-01-01

    Experiments on both stationary and propagating double layers and a related analytical model are described. Stationary double layers were produced in a multiple plasma device, in which an electron drift current was present. An investigation of the plasma parameters for the stable double layer condition is described. The particle distribution in the stable double layer establishes a potential profile, which creates electron and ion beams that excite plasma instabilities. The measured characteristics of the instabilities are consistent with the existence of the double layer. Propagating double layers are formed when the initial electron drift current is large. Ths slopes of the transition region increase as they propagate. A physical model for the formation of a double layer in the experimental device is described. This model explains the formation of the low potential region on the basis of the space charge. This space charge is created by the electron drift current. The model also accounts for the role of ions in double layer formation and explains the formation of moving double layers. (Auth.)

  11. EDITORIAL: Focus on Cold and Ultracold Molecules FOCUS ON COLD AND ULTRACOLD MOLECULES

    Science.gov (United States)

    Carr, Lincoln D.; Ye, Jun

    2009-05-01

    Cold and ultracold molecules are the next wave of ultracold physics, giving rise to an exciting array of scientific opportunities, including many body physics for novel quantum phase transitions, new states of matter, and quantum information processing. Precision tests of fundamental physical laws benefit from the existence of molecular internal structure with exquisite control. The study of novel collision and reaction dynamics will open a new chapter of quantum chemistry. Cold molecules bring together researchers from a variety of fields, including atomic, molecular, and optical physics, chemistry and chemical physics, quantum information science and quantum simulations, condensed matter physics, nuclear physics, and astrophysics, a truly remarkable synergy of scientific explorations. For the past decade there have been steady advances in direct cooling techniques, from buffer-gas cooling to cold molecular beams to electro- and magneto-molecular decelerators. These techniques have allowed a large variety of molecules to be cooled for pioneering studies. Recent amazing advances in experimental techniques combining the ultracold and the ultraprecise have furthermore brought molecules to the point of quantum degeneracy. These latter indirect cooling techniques magnetically associate atoms from a Bose-Einstein condensate and/or a quantum degenerate Fermi gas, transferring at 90% efficiency highly excited Fano-Feshbach molecules, which are on the order of 10 000 Bohr radii in size, to absolute ground state molecules just a few Bohr across. It was this latter advance, together with significant breakthroughs in internal state manipulations, which inspired us to coordinate this focus issue now, and is the reason why we say the next wave of ultracold physics has now arrived. Whether directly or indirectly cooled, heteronuclear polar molecules offer distinct new features in comparison to cold atoms, while sharing all of their advantages (purity, high coherence

  12. Preliminary Results Of A 600 Joules Small Plasma Focus Device

    International Nuclear Information System (INIS)

    Lee, S. H.; Yap, S. L.; Wong, C. S.

    2009-01-01

    Preliminary results of a 600 J (3.7 μF, 18 kV) Mather type plasma focus device operated at low pressure will be presented. The discharge is formed between a solid anode with length of 6 cm and six symmetrically and coaxially arranged cathode rods of same lengths. The cathode base is profiled in a knife-edge design and a set of coaxial plasma gun are attached to it in order to initiate the breakdown and enhance the current sheath formation. The experiments have been performed in argon gas under a low pressure condition of several microbars. The discharge current and the voltage across the electrodes during the discharge are measured with high voltage probe and current coil. The current and voltage characteristics are used to determine the possible range of operating pressure that gives good focusing action. At a narrow pressure regime of 9.0±0.5 μbar, focusing action is observed with good reproducibility. Preliminary result of ion beam energy is presented. More work will be carried out to investigate the radiation output.

  13. Low-Voltage Paper Isotachophoresis Device for DNA Focusing

    Science.gov (United States)

    Li, Xiang; Luo, Long; Crooks, Richard M.

    2015-01-01

    We present a new paper-based isotachophoresis (ITP) device design for focusing DNA samples having lengths ranging from 23 to at least 1517 bp. DNA is concentrated by more than two orders of magnitude within 4 min. The key component of this device is a 2 mm-long, 2 mm-wide circular paper channel formed by concertina folding a paper strip and aligning the circular paper zones on each layer. Due to the short channel length, a high electric field of ~16 kV/m is easily generated in the paper channel using two 9 V batteries. The multilayer architecture also enables convenient reclamation and analysis of the sample after ITP focusing by simply opening the origami paper and cutting out the desired layers. We profiled the electric field in the origami paper channel during ITP experiments using a nonfocusing fluorescent tracer. The result showed that focusing relies on formation and subsequent movement of a sharp electric field boundary between the leading and trailing electrolyte. PMID:26338530

  14. Microflow Cytometers with Integrated Hydrodynamic Focusing

    Directory of Open Access Journals (Sweden)

    Martin Schmidt

    2013-04-01

    Full Text Available This study demonstrates the suitability of microfluidic structures for high throughput blood cell analysis. The microfluidic chips exploit fully integrated hydrodynamic focusing based on two different concepts: Two-stage cascade focusing and spin focusing (vortex principle. The sample—A suspension of micro particles or blood cells—is injected into a sheath fluid streaming at a substantially higher flow rate, which assures positioning of the particles in the center of the flow channel. Particle velocities of a few m/s are achieved as required for high throughput blood cell analysis. The stability of hydrodynamic particle positioning was evaluated by measuring the pulse heights distributions of fluorescence signals from calibration beads. Quantitative assessment based on coefficient of variation for the fluorescence intensity distributions resulted in a value of about 3% determined for the micro-device exploiting cascade hydrodynamic focusing. For the spin focusing approach similar values were achieved for sample flow rates being 1.5 times lower. Our results indicate that the performances of both variants of hydrodynamic focusing suit for blood cell differentiation and counting. The potential of the micro flow cytometer is demonstrated by detecting immunologically labeled CD3 positive and CD4 positive T-lymphocytes in blood.

  15. Veselago focusing of anisotropic massless Dirac fermions

    Science.gov (United States)

    Zhang, Shu-Hui; Yang, Wen; Peeters, F. M.

    2018-05-01

    Massless Dirac fermions (MDFs) emerge as quasiparticles in various novel materials such as graphene and topological insulators, and they exhibit several intriguing properties, of which Veselago focusing is an outstanding example with a lot of possible applications. However, up to now Veselago focusing merely occurred in p-n junction devices based on the isotropic MDF, which lacks the tunability needed for realistic applications. Here, motivated by the emergence of novel Dirac materials, we investigate the propagation behaviors of anisotropic MDFs in such a p-n junction structure. By projecting the Hamiltonian of the anisotropic MDF to that of the isotropic MDF and deriving an exact analytical expression for the propagator, precise Veselago focusing is demonstrated without the need for mirror symmetry of the electron source and its focusing image. We show a tunable focusing position that can be used in a device to probe masked atom-scale defects. This study provides an innovative concept to realize Veselago focusing relevant for potential applications, and it paves the way for the design of novel electron optics devices by exploiting the anisotropic MDF.

  16. Focus is key: Panic-focused interpretations are associated with symptomatic improvement in panic-focused psychodynamic psychotherapy.

    Science.gov (United States)

    Keefe, John R; Solomonov, Nili; Derubeis, Robert J; Phillips, Alexander C; Busch, Fredric N; Barber, Jacques P; Chambless, Dianne L; Milrod, Barbara L

    2018-04-18

    This study examines whether, in panic-focused psychodynamic psychotherapy (PFPP), interpretations of conflicts that underlie anxiety (panic-focused or PF-interpretations) are specifically associated with subsequent panic disorder (PD) symptom improvement, over and above the provision of non-symptom-focused interpretations. Technique use in Sessions 2 and 10 of a 24-session PFPP protocol was assessed for the 65 patients with complete outcome data randomized to PFPP in a two-site trial of psychotherapies for PD. Sessions were rated in 15-min segments for therapists' use of PF-interpretations, non-PF-interpretations, and PF-clarifications. Robust regressions were conducted to examine the relationship between these interventions and symptom change subsequent to the sampled session. Interpersonal problems were examined as a moderator of the relationship of PF-interpretations to symptom change. At Session 10, but not at Session 2, patients who received a higher degree of PF-interpretations experienced greater subsequent improvement in panic symptoms. Non-PF-interpretations were not predictive. Patients with more interpersonal distress benefitted particularly from the use of PF-interpretations at Session 10. By the middle phase of PFPP, panic-focused interpretations may drive subsequent improvements in panic symptoms, especially among patients with higher interpersonal distress. Interpretations of conflict absent a panic focus may not be especially helpful.

  17. COMPETENCYTHE FORMATION FOR LIFE

    Directory of Open Access Journals (Sweden)

    Milagros Mederos-Piñeiro

    2016-07-01

    Full Text Available The formation of life competences is the result of a quality education that prepares students to meet the challenges of a fast moving world where equality and equal opportunities should constitute premises of education; training them is a challenge teachers to assume new generations contribute actively to a better world. In Cuba are important research on the formation of communication competences and self-regulated learning in primary school. The paper shows the result of an investigation that provides a methodology for the formation of life competences in primary school education, used as an essential pathway research activity. The methodological approach of research has a quantitative approach and an explanatory scope to establish and make sense of understanding the causal relationship between the direction of research activity and training of life competences. Theoretical, empirical and mathematical-statistical, for characterizing the initial state, processing of results and analysis: research methods are used. The application of the methodology for the formation of life competences makes teachers lead the teaching-learning process with a research and transforming teaching concept, where the school is the protagonist of their learning and causes changes in their performances, which are evident in the formed competences related to effective and affective communication; the solution of problems related to life; the use of means in obtaining the knowledge and the expression of a behavior consistent with school and social demands. The effectiveness of the methodology confirms that there is a causal relationship between the direction of research activity by teachers and the formation of life competences in school.

  18. EPA Region 7 Aquatic Focus Areas (ECO_RES.R7_AQUATIC_FOCUS_AREAS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This shapefile consists of 347 individual Aquatic Ecological System (AES) polygons that are the Aquatic Conservation Focus Areas for EPA Region 7. The focus areas...

  19. Star formation in evolving molecular clouds

    Science.gov (United States)

    Völschow, M.; Banerjee, R.; Körtgen, B.

    2017-09-01

    Molecular clouds are the principle stellar nurseries of our universe; they thus remain a focus of both observational and theoretical studies. From observations, some of the key properties of molecular clouds are well known but many questions regarding their evolution and star formation activity remain open. While numerical simulations feature a large number and complexity of involved physical processes, this plethora of effects may hide the fundamentals that determine the evolution of molecular clouds and enable the formation of stars. Purely analytical models, on the other hand, tend to suffer from rough approximations or a lack of completeness, limiting their predictive power. In this paper, we present a model that incorporates central concepts of astrophysics as well as reliable results from recent simulations of molecular clouds and their evolutionary paths. Based on that, we construct a self-consistent semi-analytical framework that describes the formation, evolution, and star formation activity of molecular clouds, including a number of feedback effects to account for the complex processes inside those objects. The final equation system is solved numerically but at much lower computational expense than, for example, hydrodynamical descriptions of comparable systems. The model presented in this paper agrees well with a broad range of observational results, showing that molecular cloud evolution can be understood as an interplay between accretion, global collapse, star formation, and stellar feedback.

  20. Medusae Fossae Formation

    Science.gov (United States)

    2002-01-01

    (Released 10 April 2002) The Science This THEMIS visible image was acquired near 7o S, 172o W (188o E) and shows a remarkable martian geologic deposit known as the Medusae Fossae Formation. This Formation, seen here as the raised plateau in the upper two-thirds of the image, is a soft, easily eroded deposit that extends for nearly 1,000 km along the equator of Mars. In this region the deposit has been heavily eroded by the wind to produce a series of linear ridges called yardangs. These parallel ridges point in direction of the prevailing winds that carved them, and demonstrate the power of martian winds to sculpt the dry landscape of Mars. The Medusae Fossae Formation has been completely stripped from the surface in the lower third of the image, revealing a harder layer below that is more resistant to wind erosion. The easily eroded nature of the Medusae Fossae Formation suggests that it is composed of weakly cemented particles, and was most likely formed by the deposition of wind-blown dust or volcanic ash. Several ancient craters that were once completely buried by this deposit are being exposed, or exhumed, as the overlying Medusae Formation is removed. Very few impact craters are visible on this Formation, indicating that the surface seen today is relatively young, and that the processes of erosion are likely to be actively occurring. The Story Medusa of Greek mythology fame, the name-giver to this region, had snaky locks of hair that could turn a person to stone. Wild and unruly, this monster of the underworld could certainly wreak havoc on the world of the human imagination. As scary as she was, Medusa would have no advantage over the fierce, masterful winds blowing across Mars, which once carved the streaky, terrain at the top of this image. Wild and whipping, these winds have slowly eroded away the 'topsoil,' revealing ancient craters and other surface features they once covered. The loosely cemented particles of this 'topsoil' are likely made up of dust

  1. Thermodynamics and kinetics of vesicles formation processes.

    Science.gov (United States)

    Guida, Vincenzo

    2010-12-15

    Vesicles are hollow aggregates, composed of bilayers of amphiphilic molecules, dispersed into and filled with a liquid solvent. These aggregates can be formed either as equilibrium or as out of equilibrium meta-stable structures and they exhibit a rich variety of different morphologies. The surprising richness of structures, the vast range of industrial applications and the presence of vesicles in a number of biological systems have attracted the interest of numerous researchers and scientists. In this article, we review both the thermodynamics and the kinetics aspects of the phenomena of formation of vesicles. We start presenting the thermodynamics of bilayer membranes formation and deformation, with the aim of deriving the conditions for the existence of equilibrium vesicles. Specifically, we use the results from continuum thermodynamics to discuss the possibility of formation of stable equilibrium vesicles, from both mixed amphiphiles and single component systems. We also link the bilayer membrane properties to the molecular structure of the starting amphiphiles. In the second part of this article, we focus on the dynamics and kinetics of vesiculation. We review the process of vesicles formation both from planar lamellar phase under shear and from isotropic micelles. In order to clarify the physical mechanisms of vesicles formation, we continuously draw a parallel between emulsification and vesiculation processes. Specifically, we compare the experimental results, the driving forces and the relative scaling laws identified for the two processes. Describing the dynamics of vesicles formation, we also discuss why non equilibrium vesicles can be formed by kinetics control and why they are meta-stable. Understanding how to control the properties, the stability and the formation process of vesicles is of fundamental importance for a vast number of industrial applications. Copyright © 2009. Published by Elsevier B.V.

  2. Phase analysis and focusing of synchrotron radiation

    CERN Document Server

    Chubar, O; Snigirev, A

    1999-01-01

    High accuracy calculations of synchrotron radiation (SR) emitted by a relativistic electron show that the phase of the frequency domain electric field of SR differs from the phase of radiation of a virtual point source. These differences may result in the reduction of focusing efficiency of diffraction-limited SR, if the focusing is performed by conventional optical components optimised for point sources. We show that by applying a phase correction locally, one may transform the phase of SR electric field at a desired polarisation to that of a point source. Such corrections are computed for undulator radiation (planar and helical) and bending magnet radiation (central part and edges). The focusing of the corrected SR wavefront can result in the increase of peak intensity in the focused spot up to several times compared to the focusing without correction. For non-diffraction-limited radiation, the effect of the phase corrections is reduced. Due to this reason, the use of the proposed phase corrections in exist...

  3. The Realization of Focus in Asturian Spanish

    Directory of Open Access Journals (Sweden)

    Covadonga Sánchez-Alvarado

    2018-01-01

    Full Text Available Spanish was classified as a language that only exploits syntactic mechanisms to mark focus. Recent experimental studies, nonetheless, have shown that speakers of different dialects are also able to use prosody to different degrees. This study aims to provide further understanding on the role played by prosody in the realization of focus in Spanish by looking at Asturian Spanish, a dialect in contact with another Romance language, Asturian. The data from a contextualized sentence completion task revealed that a phonological distinction between specific pitch categories (L+focus being elicited (i.e., informational/non-corrective vs. contrastive/corrective. Nonetheless, it also showed that speakers exploit different prosodic features (i.e., pitch range, alignment, and duration to mark focus constituents, although their use differs as a result of that constituents’ function. These findings provide further support for the consideration of languages and specific dialects in a continuum based on the degree to which they use prosody to mark focus and to explore more in detail the phonetic implementation of focal accents.

  4. Axial sheath dynamics in a plasma focus

    International Nuclear Information System (INIS)

    Soliman, H.M.; El-Khalafawy, T.A.; Masoud, M.M.

    1990-01-01

    This paper presents the result of investigation with a 10 kJ Mather type plasma focus. It is operated in hydrogen gas at ambient pressure of 0.15--1 torr and charging voltage of 8--11 kV. Radial distribution of the current sheath density with axial distance has been estimated. Plasma rotation in the expansion chamber in the absence of external magnetic field has been detected. A plasma flare from the plasma focus region propagating in the radial direction has been observed. Streak photography shows two plasma streams flowing simultaneously out of the muzzle. The mean energy of the electron beam ejected from the pinch region of the focused plasma, was measured by retarding field analyzer to be 0.32 keV. The electron temperature of the plasma focus at peak compression was determined by measuring the X-ray intensity as a function of absorber thickness at a distance of 62 cm from the focus. The electron temperature has been found to 3 keV

  5. [Aerodynamic focusing of particles and heavy molecules

    International Nuclear Information System (INIS)

    de la Mora, J.F.

    1990-01-01

    By accelerating a gas containing suspended particles or large molecules through a converging nozzle, the suspended species may be focused and therefore used to write fine lines on a surface. Our objective was to study the limits on how narrow this focal region could be as a function of particle size. We find that, for monodisperse particles with masses m p some 3.6 x 10 5 times larger than the molecular mass m of the carrier gas (diameters above some 100 angstrom), there is no fundamental obstacle to directly write submicron features. However, this conclusion has been verified experimentally only with particles larger than 0.1 μm. Experimental, theoretical and numerical studies on the defocusing role of Brownian motion for very small particles or heavy molecules have shown that high resolution (purely aerodynamic) focusing is impossible with volatile molecules whose masses are typically smaller than 1000 Dalton. For these, the minimal focal diameter after optimization appears to be 5√(m/m p ) times the nozzle diameter d n . But combinations of focused lasers and aerodynamic focusing appear as promising for direct writing with molecular precursors. Theoretical and numerical schemes capable of predicting the evolution of the focusing beam, including Brownian motion effects, have been developed, although further numerical work would be desirable. 11 refs

  6. The format of things

    DEFF Research Database (Denmark)

    Jørnø, Rasmus Leth

    this conception is identified as “the Format of Things.” The format is embedded in our everyday thinking. In relation to design,it is found in the name taken by the design community, that is human-computer interaction (HCI), and it is mirrored in the desktop metaphor, wherein information is conceived...... available. It consists of philosophical considerations on matters of relevance for the design of interfaces. It takes the position that the graphical user interfaces of computers (the Desktop Metaphor or Windows, Icons, Menus, Pointers [‘WIMP’]) that ordinarily come to mind for most people are cognates......The development of novel interfaces is one of the most important current design challenges for the intellectual, cultural and cognitive evolution of human imagination and knowledge work. Unfortunately, the thinking surrounding this design challenge is heavily mired in conceptions that harbor...

  7. Plasma formation in TBR

    International Nuclear Information System (INIS)

    Del Bosco, E.

    1981-01-01

    In this work are presented and discussed results of the formation and equilibrium of the plasma current in TBR, a small tokamak, designed and contructed at the Instituto de Fisica of Universidade de Sao Paulo. The measured breakdown curves for H 2 , A and He are compared with the predictions of a simple model with reasonable agreement. The influence of stray magnetic fields in the plasma formation is investigated and conditions are chosen to facilitate the breakdown. The time profile of loop voltage and plasma current for shots with plasma equilibrium are shown. A comparison is made between experimental results and analytical-numerical model for tokamaks discharges with ohmic heating. Reasonable agreement is obtained when Z, effective atomic number, is assumed as a parameter. (Author) [pt

  8. Formation of coronal cavities

    International Nuclear Information System (INIS)

    An, C.H.; Suess, S.T.; Tandberg-Hanssen, E.; Steinolfson, R.S.

    1986-01-01

    A theoretical study of the formation of a coronal cavity and its relation to a quiescent prominence is presented. It is argued that the formation of a cavity is initiated by the condensation of plasma which is trapped by the coronal magnetic field in a closed streamer and which then flows down to the chromosphere along the field lines due to lack of stable magnetic support against gravity. The existence of a coronal cavity depends on the coronal magnetic field strength; with low strength, the plasma density is not high enough for condensation to occur. Furthermore, we suggest that prominence and cavity material is supplied from the chromospheric level. Whether a coronal cavity and a prominence coexist depends on the magnetic field configuration; a prominence requires stable magnetic support

  9. Understanding Alliance Formation Patterns

    Science.gov (United States)

    2015-12-01

    military, transportation, and communications technologies, which caused every place in the world to be politically significant. Second, “divisions of power...test a similar claim about the association between distance and dyadic alliance formation. In their first model, in which they use the complete data...1885 to 1990] are positively related to dyadic trade levels, and that their non- defense-pact counterparts are not significantly related to trade in

  10. Alkali metal hydride formation

    International Nuclear Information System (INIS)

    1976-01-01

    The present invention relates to a method of producing alkali metal hydrides by absorbing hydrogen gas under pressure into a mixture of lower alkyl mono amines and alkali metal alkyl amides selected from sodium and potassium amides formed from said amines. The present invention also includes purification of a mixture of the amines and amides which contain impurities, such as is used as a catalytic exchange liquid in the enrichment of deuterium, involving the formation of the alkali metal hydride

  11. Formation of TRAPPIST-1

    Science.gov (United States)

    Ormel, C. W.; Liu, B.; Schoonenberg, D.

    2017-09-01

    We present a model for the formation of the recently-discovered TRAPPIST-1 planetary system. In our scenario planets form in the interior regions, by accretion of mm to cm-size particles (pebbles) that drifted from the outer disk. This scenario has several advantages: it connects to the observation that disks are made up of pebbles, it is efficient, it explains why the TRAPPIST-1 planets are ˜Earth mass, and it provides a rationale for the system's architecture.

  12. THE ALLIANCE FORMATION PROCESS

    OpenAIRE

    Whipple, Judith M.; Frankel, Robert

    1998-01-01

    While interest in developing strategic alliances within the food system continues to increase, there remains considerable risk when firms adopt such a cooperative strategy. The risk is due in part to the lack of concrete guidelines that illustrate the steps or stages of alliance development and the important strategic and operational decisions required at each stage. The existence of such guidelines would facilitate alliance formation and enable managers and researchers to better understand a...

  13. Task-focused modeling in automated agriculture

    Science.gov (United States)

    Vriesenga, Mark R.; Peleg, K.; Sklansky, Jack

    1993-01-01

    Machine vision systems analyze image data to carry out automation tasks. Our interest is in machine vision systems that rely on models to achieve their designed task. When the model is interrogated from an a priori menu of questions, the model need not be complete. Instead, the machine vision system can use a partial model that contains a large amount of information in regions of interest and less information elsewhere. We propose an adaptive modeling scheme for machine vision, called task-focused modeling, which constructs a model having just sufficient detail to carry out the specified task. The model is detailed in regions of interest to the task and is less detailed elsewhere. This focusing effect saves time and reduces the computational effort expended by the machine vision system. We illustrate task-focused modeling by an example involving real-time micropropagation of plants in automated agriculture.

  14. Focusing properties of cylindrical vector vortex beams

    Science.gov (United States)

    Xiaoqiang, Zhang; Ruishan, Chen; Anting, Wang

    2018-05-01

    In this paper, following Richards and Wolf vectorial diffraction theory, the focusing properties of cylindrical vector vortex beams (CVVB) are investigated, and a diffractive optical element (DOE) is designed to spatially modulate the amplitude of the CVVB. Simulated results show that the CVVB focused by an objective also carry orbital angular momentum (OAM), and the optical fields near the focal region can be modulated by changing the topological charge of the CVVB. We numerically simulate the focus properties of radially and azimuthally polarized beams with topological charge equal to 0, 1, 2 and 10 respectively. As a result, a dark channel with a length about 20 λ can be obtained. These new properties have the potential applications such as particle acceleration, optical trapping and material processing.

  15. Final focus systems for linear colliders

    International Nuclear Information System (INIS)

    Helm, R.; Irwin, J.

    1992-08-01

    Final focus systems for linear colliders present many exacting challenges in beam optics, component design, and beam quality. Efforts to resolve these problems as they relate to a new generation of linear colliders are under way at several laboratories around the world. We will outline criteria for final focus systems and discuss the current state of understanding and resolution of the outstanding problems. We will discuss tolerances on alignment, field quality and stability for optical elements, and the implications for beam parameters such as emittance, energy spread, bunch length, and stability in position and energy. Beam-based correction procedures, which in principle can alleviate many of the tolerances, will be described. Preliminary results from the Final Focus Test Beam (FFTB) under construction at SLAC will be given. Finally, we mention conclusions from operating experience at the Stanford Linear Collider (SLC)

  16. Final focus systems for linear colliders

    International Nuclear Information System (INIS)

    Helm, R.; Irwing, J.

    1992-01-01

    Final focus systems for linear colliders present many exacting challenges in beam optics, component design, and beam quality. Efforts to resolve these problems as they relate to a new generation of linear colliders are under way at several laboratories around the world. We outline criteria for final focus systems and discuss the current state of understanding and resolution of the outstanding problems. We discuss tolerances on alignment, field quality and stability for optical elements, and the implications for beam parameters such as emittance, energy spread , bunch length, and stability in position and energy. Beam-based correction procedures, which in principle can alleviate many of the tolerances, are described. Preliminary results from the Final Focus Test Beam (FFTB) under construction at SLAC are given. Finally, we mention conclusions from operating experience at the Stanford Linear Collider (SLC). (Author) 16 refs., 4 tabs., 6 figs

  17. Nova frequency conversion and focusing system

    International Nuclear Information System (INIS)

    Summers, M.A.; Seppala, L.G.; Williams, J.D.

    1985-01-01

    New developments in crystal array technology provided significant improvements in the mechanical design and optical performance of the Nova 2 omega/3 omega array hardware. The final Nova array configuration was tested on the Novette laser and on the first arm of Nova. Ten Nova 2 omega/3 omega crystal arrays were assembled and tested for crystal alignment and wave front distortion before installation on the Nova target chamber. Ten Nova focus lens positioners were assembled and tested last year. The positioning accuracy and repeatability of each assembly were evaluated before installation on the target chamber. A cylindrical focusing system was also developed for installation in the Nova lens positioner assembly. Finally, 10 completed frequency conversion and focusing systems were activated

  18. Radiation damping in focusing-dominated systems

    International Nuclear Information System (INIS)

    Huang, Zhirong; Chen, Pisin; Ruth, R.D.

    1995-01-01

    A quasi-classical method is developed to calculate the radiation damping of a relativistic particle in a straight, continuous focusing system. In one limiting case where the pitch angle of the particle θ p is much larger than the radiation opening angle 1/γ, the radiation power spectrum is similar to synchrotron radiation and the relative damping rate of the transverse action is proportional to the relative energy loss rate. In the other limiting case where θ p much-lt 1/γ, the radiation is dipole in nature and the relative damping rate of the transverse action is energy-independent and is much faster than the relative energy rate. Quantum excitation to the transverse action is absent in this focusing channel. These results can be extended to bent systems provided that the focusing field dominates over the bending field

  19. Bringing customer focus to power generation

    Energy Technology Data Exchange (ETDEWEB)

    Mahoney, J.V. [USGen Power Services (United States)

    1997-02-01

    The restructuring of the power generation industry and the impact it will have on a company`s success was discussed. Some companies are following one of three distinct strategies for survival, the GENCO, MARKETCO and TRADECO. The GENCO focuses on aggregating low cost, kick butt generation assets that could be either regionally concentrated or geographically distributed. The TRADECO invests in few, or even no, assets. Its only objective is to maximize net income. The MARKETCO structure focuses on understanding and meeting customers` needs. The MARKETCO puts as much value in aggregating `load` as it does on assets. It was suggested that the MARKETCO was the quickest path to success in the restructured electric industry, since it is plainly evident that in the New Millenium the customer will be king, and companies will not survive unless they focus the majority of their efforts on the customer.

  20. Final Focus Systems in Linear Colliders

    International Nuclear Information System (INIS)

    Raubenheimer, Tor

    1998-01-01

    In colliding beam facilities, the ''final focus system'' must demagnify the beams to attain the very small spot sizes required at the interaction points. The first final focus system with local chromatic correction was developed for the Stanford Linear Collider where very large demagnifications were desired. This same conceptual design has been adopted by all the future linear collider designs as well as the SuperConducting Supercollider, the Stanford and KEK B-Factories, and the proposed Muon Collider. In this paper, the over-all layout, physics constraints, and optimization techniques relevant to the design of final focus systems for high-energy electron-positron linear colliders are reviewed. Finally, advanced concepts to avoid some of the limitations of these systems are discussed

  1. Complexity and formative experiences

    Directory of Open Access Journals (Sweden)

    Roque Strieder

    2017-12-01

    Full Text Available The contemporaneity is characterized by instability and diversity calling into question certainties and truths proposed in modernity. We recognize that the reality of things and phenomena become effective as a set of events, interactions, retroactions and chances. This different frame extends the need for revision of the epistemological foundations that sustain educational practices and give them sense. The complex thinking is an alternative option for acting as a counterpoint to classical science and its reductionist logic and knowledge compartmentalization, as well as to answer to contemporary epistemological and educational challenges. It aims to associate different areas and forms of knowledge, without, however merge them, distinguishing without separating the several disciplines and instances of the realities. This study, in theoretical references, highlights the relevance of complex approaches to support formative experiences because also able to produce complexities in reflections about educational issues. We conclude that formative possibilities from complexity potentialize the resignification of human’s conception and the understanding of its singularity in interdependence; The understanding that pedagogical and educational activities is a constant interrogation about the possibilities of knowing the knowledge and reframe learning, far beyond knowing its functions and utilitarian purposes; and, as a formative possibility, places us on the trail of responsibility, not as something eventual, but present and indicative of freedom to choose to stay or go beyond.

  2. Terrestrial planet formation.

    Science.gov (United States)

    Righter, K; O'Brien, D P

    2011-11-29

    Advances in our understanding of terrestrial planet formation have come from a multidisciplinary approach. Studies of the ages and compositions of primitive meteorites with compositions similar to the Sun have helped to constrain the nature of the building blocks of planets. This information helps to guide numerical models for the three stages of planet formation from dust to planetesimals (~10(6) y), followed by planetesimals to embryos (lunar to Mars-sized objects; few 10(6) y), and finally embryos to planets (10(7)-10(8) y). Defining the role of turbulence in the early nebula is a key to understanding the growth of solids larger than meter size. The initiation of runaway growth of embryos from planetesimals ultimately leads to the growth of large terrestrial planets via large impacts. Dynamical models can produce inner Solar System configurations that closely resemble our Solar System, especially when the orbital effects of large planets (Jupiter and Saturn) and damping mechanisms, such as gas drag, are included. Experimental studies of terrestrial planet interiors provide additional constraints on the conditions of differentiation and, therefore, origin. A more complete understanding of terrestrial planet formation might be possible via a combination of chemical and physical modeling, as well as obtaining samples and new geophysical data from other planets (Venus, Mars, or Mercury) and asteroids.

  3. The plasma focus - numerical experiments leading technology

    International Nuclear Information System (INIS)

    Saw, S.H.; Lee, S.

    2013-01-01

    Numerical experiments on the plasma focus are now used routinely to assist design and provide reference points for diagnostics. More importantly guidance has been given regarding the implementation of technology for new generations of plasma focus devices. For example intensive series of experiments have shown that it is of no use to reduce static bank inductance L0 below certain values because of the consistent loading effects of the plasma focus dynamics on the capacitor bank. Thus whilst it was thought that the PF1000 could receive major benefits by reducing its bank inductance L 0 , numerical experiments have shown to the contrary that its present L 0 of 30 nH is already optimum and that reducing L 0 would be a very expensive fruitless exercise. This knowledge gained from numerical experiments now acts as a general valuable guideline to all high performance (ie low inductance) plasma focus devices not to unnecessarily attempt to further lower the static inductance L 0 . The numerical experiments also show that the deterioration of the yield scaling law (e.g. the fusion neutron yield scaling with storage energy) is inevitable again due to the consistent loading effect of the plasma focus, which becomes more and more dominant as capacitor bank impedance reduces with increasing capacitance C 0 as storage energy is increased. This line of thinking has led to the suggestion of using higher voltages (as an alternative to increasing C 0 ) and to seeding of Deuterium with noble gases in order to enhance compression through thermodynamic mechanisms and through radiation cooling effects of strong line radiation. Circuit manipulation e.g. to enhance focus pinch compression by current-stepping is also being numerically experimented upon. Ultimately however systems have to be built, guided by numerical experiments, so that the predicted technology may be proven and realized. (author)

  4. Focus measurement of electron linear accelerator

    International Nuclear Information System (INIS)

    Su Zhijun; Xin Jian; Jia Qinglong

    2007-01-01

    Many personal factors would influence the result of the focus measurement of linear accelerator using the conventional sandwich method. This paper presents a modified method which applies a film scanning meter to scan the X-ray image film got by sandwich method for obtaining a greyscale distribution, then the full width at half maximum value of greyscale distribution represents the focus size. The method can eliminates disadvantage influence from accelerator radiant field asymmetry by quadratic polynomial fitting and measures peak width at half height instead of stripe statistic. (authors)

  5. CY15 Livermore Computing Focus Areas

    Energy Technology Data Exchange (ETDEWEB)

    Connell, Tom M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Cupps, Kim C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); D' Hooge, Trent E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fahey, Tim J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fox, Dave M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Futral, Scott W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gary, Mark R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Goldstone, Robin J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hamilton, Pam G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heer, Todd M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Long, Jeff W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Mark, Rich J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Morrone, Chris J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Shoopman, Jerry D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Slavec, Joe A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Smith, David W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Springmeyer, Becky R [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Stearman, Marc D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Watson, Py C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-01-20

    The LC team undertook a survey of primary Center drivers for CY15. Identified key drivers included enhancing user experience and productivity, pre-exascale platform preparation, process improvement, data-centric computing paradigms and business expansion. The team organized critical supporting efforts into three cross-cutting focus areas; Improving Service Quality; Monitoring, Automation, Delegation and Center Efficiency; and Next Generation Compute and Data Environments In each area the team detailed high level challenges and identified discrete actions to address these issues during the calendar year. Identifying the Center’s primary drivers, issues, and plans is intended to serve as a lens focusing LC personnel, resources, and priorities throughout the year.

  6. Foil focusing of relativistic electron beams

    Energy Technology Data Exchange (ETDEWEB)

    Ekdahl, Jr., Carl August [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-10-26

    When an intense relativistic electron beams (IREB) passes through a grounded metal foil, the transverse electric field due to the beam space charge is locally shorted out, and the beam is focused by the magnetic field of its current. The effect can be treated as focusing by a thin lens with first order aberration. Expressions for the focal length and aberration coefficient of the equivalent thin lens are developed in this note. These are then applied to practical examples representative of IREB research at Los Alamos National Laboratory.

  7. ECONOMIC STRATEGY CREATED THROUGH THEORY FOCUSED PLANNING

    Directory of Open Access Journals (Sweden)

    Dumitru-Alexandru Bodislav

    2011-06-01

    Full Text Available The research done for this article is following the elaboration of a moldable model on the actual economic context, in which there are considered continuous learning elements on facts and commercial niches, evaluating a business starting from causality diagram and structuring its processes. Analyzing the evolution of a business and on the market in which they are deploying their activity through quantitative and qualitative measurement methods focused on trends. Testing hypotheses and business suppositions that are the main engine of theory focused on planning, a model of creating a strategic management process that will be developed in this article.

  8. SKEW QUADRUPOLE FOCUSING LATTICES AND APPLICATIONS

    International Nuclear Information System (INIS)

    Parker, B.

    2001-01-01

    In this paper we revisit using skew quadrupole fields in place of traditional normal upright quadrupole fields to make beam focusing structures. We illustrate by example skew lattice decoupling, dispersion suppression and chromatic correction using the neutrino factory Study-II muon storage ring design. Ongoing BNL investigation of flat coil magnet structures that allow building a very compact muon storage ring arc and other flat coil configurations that might bring significant magnet cost reduction to a VLHC motivate our study of skew focusing

  9. A self-focusing mercury jet target

    CERN Document Server

    Johnson, C

    2002-01-01

    Mercury jet production targets have been studied in relation to antiproton production and, more recently, pion production for a neutrino factory. There has always been a temptation to include some self-focusing of the secondaries by passing a current through the mercury jet analogous to the already proven lithium lens. However, skin heating of the mercury causes fast vaporization leading to the development of a gliding discharge along the surface of the jet. This external discharge can, nevertheless, provide some useful focusing of the secondaries in the case of the neutrino factory. The technical complications must not be underestimated.

  10. Neutron emission from deuterium plasma focus

    International Nuclear Information System (INIS)

    Antanasijevic, R.; Banjanac, R.; Dragic, A.; Djordjevic, D.; Joksimovic, D.; Maric, Z.; Udovicic, V.; Vukovic, J.

    1998-01-01

    The anisotropy of emitted neutrons is investigated on a small 'Mather-type' plasma focus device (PF). This problem is of importance for determining the nature of the fusion reaction mechanisms. Mica detectors together with thick uranium foils were used for both detection and angular distribution measurements of the neutrons. Previously, the annealing of the detectors was done and measured after the irradiation with neutrons from Am-Be source. Also, annealing ability of H-plasma focus has been tested. Geometry of detectors in both experiments was the same. (authors)

  11. Radiation reaction in a continuous focusing channel

    International Nuclear Information System (INIS)

    Huang, Z.; Chen, P.; Ruth, R.D.

    1995-01-01

    We show that the radiation damping rate of the transverse action of a particle in a straight, continuous focusing system is independent of the particle energy, and that no quantum excitation is induced. This absolute damping effect leads to the existence of a transverse ground state to which the particle inevitably decays and yields the minimum beam emittance that one can ever attain, γε min =ℎ/2mc, limited only by the uncertainty principle. Because of adiabatic invariance, the particle can be accelerated along the focusing channel in its ground state without any radiation energy loss

  12. Production of radioisotopes within a plasma focus device

    International Nuclear Information System (INIS)

    Angeli, E.; Tartari, A.; Frignani, M.; Molinari, V.; Mostacci, D.; Rocchi, F.; Sumini, M. . E-mail address of corresponding author: domiziano.mostacci@mail.ing.unibo.it

    2005-01-01

    In recent years, research conducted in the US and in Italy has demonstrated production of radioisotopes in Plasma Focus (PF) devices, and particularly, on what could be termed 'endogenous' production, to wit, production within the plasma itself, as opposed to irradiation of targets. This technique relies on the formation of localized small plasma zones characterized by very high densities and fairly high temperatures. The conditions prevailing in these zones lead to high nuclear reaction rates, as pointed out in previous work by several authors. Further investigation of the cross sections involved has proven necessary to model the phenomena involved. In this paper, the present status of research in this field is reviewed, both with regards to cross section models and to experimental production of radioisotopes. Possible outcomes and further development are discussed. (author)

  13. Fully kinetic simulations of megajoule-scale dense plasma focus

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, A.; Link, A.; Tang, V.; Halvorson, C.; May, M. [Lawrence Livermore National Laboratory, Livermore California 94550 (United States); Welch, D. [Voss Scientific, LLC, Albuquerque, New Mexico 87108 (United States); Meehan, B. T.; Hagen, E. C. [National Security Technologies, LLC, Las Vegas, Nevada 89030 (United States)

    2014-10-15

    Dense plasma focus (DPF) Z-pinch devices are sources of copious high energy electrons and ions, x-rays, and neutrons. Megajoule-scale DPFs can generate 10{sup 12} neutrons per pulse in deuterium gas through a combination of thermonuclear and beam-target fusion. However, the details of the neutron production are not fully understood and past optimization efforts of these devices have been largely empirical. Previously, we reported on the first fully kinetic simulations of a kilojoule-scale DPF and demonstrated that both kinetic ions and kinetic electrons are needed to reproduce experimentally observed features, such as charged-particle beam formation and anomalous resistivity. Here, we present the first fully kinetic simulation of a MegaJoule DPF, with predicted ion and neutron spectra, neutron anisotropy, neutron spot size, and time history of neutron production. The total yield predicted by the simulation is in agreement with measured values, validating the kinetic model in a second energy regime.

  14. Food security: what the community wants. Learning through focus groups.

    Science.gov (United States)

    Hargrove, D; Dewolfe, J A; Thompson, L

    1994-01-01

    We used focus groups to learn the range of issues threatening food security of low income residents in our community. Five major themes emerged from the discussions: literacy, money, time, mental health and self-esteem, suggesting several approaches that could help ensure food security: 1) education, 2) sharing of resources, 3) coalition building, and 4) advocacy. Education programs have to be practical, allowing for demonstrations and hands-on learning while emphasizing skill building and problem solving. Incorporating a social aspect into learning may compensate for the social isolation and would capitalize on the impressive mutual support we witnessed. Strategies based on self-help and peer assistance may counteract low self-esteem and overcome suspicion of health professionals. A community-wide effort is needed to address the factors contributing to food insecurity. We envision the formation of a coalition of professionals, agencies, and low income people to develop a comprehensive strategy for achieving food security.

  15. Dose Measurements in a 20-J Repetitive Plasma Focus

    Science.gov (United States)

    Goudarzi, S.; Babaee, H.; Esmaeli, A.; Nasiri, A.; Mazandarani, A.

    2018-02-01

    In this article, the results of X-ray dose measurements executed using thermoluminescent dosimeters in experiments with a very small (20 J) repetitive plasma focus device named SORENA-1 are presented and analyzed. The working gas in these experiments was Argon. Also, pinch formation in experiments with this device has been observed. This device has been designed and constructed in Plasma and Nuclear Fusion Research School of Nuclear Science and Technology Research Institute of Iran. From these results, it is concluded that we can do experiments with this device using Ar as working gas all over the working days of year, and a good symmetry for measured dose around the device has been seen.

  16. The problem of focusing and real images

    Energy Technology Data Exchange (ETDEWEB)

    Mihas, Pavlos [Department of Elementary Education, Demokritus University, Nea Chili, Alexandroupolis, Gr-68100 (Greece)], E-mail: pmichas@eled.duth.gr

    2008-05-15

    A historical discussion of the theories which deal with the formation of real images in mirrors and lenses is presented in this paper. Speculations on mirrors appeared as early as Plato. Euclid's, Hero's and Ptolemy's approaches to visual rays are described. The theory on burning mirrors starts with Diocles and later was continued by the Arabs. Al Haytham extensively studied the reflection of light rays on concave mirrors. Huygens tried to find a shorter way to do the calculations. With lenses Kepler gave a new way of finding the position of images by using approximations. Huygens also gave a solution for the shape of a 'perfect' lens. Huygens' principle on waves can be combined with Fermat's principle to explain the formation of images. These theories can be used in education to help students better understand the formation of images, the propagation of waves and the properties of lenses.

  17. Narrative, Preaching, and Formation

    Science.gov (United States)

    Finney, Mark David

    2017-01-01

    This dissertation focuses on the place of narrative in the transformational encounter that can take place between hearers of sermons and God. Chapter 1 surveys the history and development of contemporary scholarship related to narrative preaching. It argues that most homileticians consider narrative either as a way of structuring sermons, or as a…

  18. Sharp Focus on Soft Skills: A Case Study of Malaysian University Students' Educational Expectations

    Science.gov (United States)

    Nikitina, Larisa; Furuoka, Fumitaka

    2012-01-01

    In 2006, the Ministry of Higher Education, Malaysia, recommended that all public institutions of higher learning in the country incorporate soft skills formation into their curricula. This qualitative study aimed to explore Malaysian students' expectations of university education with a special focus on the acquisition of soft skills and to…

  19. International Focus: Highlighting APPA Members Worldwide

    Science.gov (United States)

    Glazner, Steve, Comp.

    2011-01-01

    While most APPA member institutions are located in the United States and Canada, there are also 45 of member institutions located internationally--from Australia and New Zealand to Southeast Asia to the Middle East to Europe. This article focuses on four of its international members: (1) American University of Kuwait (AUK); (2) American University…

  20. Content-Focused Coaching: Five Key Practices

    Science.gov (United States)

    Gibbons, Lynsey K.; Cobb, Paul

    2016-01-01

    Many districts are using content-focused coaching as a strategy to provide job-embedded support to teachers. However, the current coaching literature provides little guidance on what coaches need to know and be able to do to engage teachers in activities that will support their development of ambitious instructional practices. Furthermore, little…

  1. Magnetohydrodynamic studies of the strong Focus device

    International Nuclear Information System (INIS)

    Vezin, Robert

    1971-01-01

    The POTTER magnetohydrodynamic code is used. It consists of a two-dimensional fluid model with two temperatures Te, Ti and transverse transport coefficients for a fully ionized plasma. Applied to the FOCUS geometry used at Limeil, it gives temperatures consistent with the BENNETT law but much lower than those evaluated experimentally by the X-ray absorbing foils technique. (author) [fr

  2. Training Manual. Focused Observations: Nonverbal Teaching Behavior.

    Science.gov (United States)

    Bradley, Banks; And Others

    Nonverbal teacher behavior is recognized as an important factor in establishing a positive social climate in the classroom. A feedback and analysis instrument is presented focusing on specific nonverbal teacher behaviors. These behaviors--facial expressions, gestures, body movements, and idiosyncratic characteristics--are categorized as either…

  3. Science Education at Arts-Focused Colleges

    Science.gov (United States)

    Oswald, W. Wyatt; Ritchie, Aarika; Murray, Amy Vashlishan; Honea, Jon

    2016-01-01

    Many arts-focused colleges and universities in the United States offer their undergraduate students coursework in science. To better understand the delivery of science education at this type of institution, this article surveys the science programs of forty-one arts-oriented schools. The findings suggest that most science programs are located in…

  4. Careers in focus library and information science

    CERN Document Server

    2011-01-01

    Careers in Focus: Library and Information Science, Second Edition profiles 19 careers for professionals interested in this field. Job profiles include:. -Acquisitions librarians. -Book conservators. -Children's librarians. -Corporate librarians. -Film and video librarians. -Law librarians. -Library assistants. -Library media specialists. -Medical librarians. -Research assistants.

  5. The stabilisation of final focus system

    Indian Academy of Sciences (India)

    The StaFF (stabilisation of final focus) system will use interferometers to monitor the relative ... quadrupole magnets will be the most demanding application, where mutual and beam- ... interferometers to measure lines of a geodetic network to record relative motion between two beam ... coupled interferometer design.

  6. GRI: focusing on the evolving violent universe

    DEFF Research Database (Denmark)

    Knodlseder, J.; von Ballmoos, P.; Frontera, F.

    2009-01-01

    The gamma-ray imager (GRI) is a novel mission concept that will provide an unprecedented sensitivity leap in the soft gamma-ray domain by using for the first time a focusing lens built of Laue diffracting crystals. The lens will cover an energy band from 200-1,300 keV with an effective area reach...... processes in the universe....

  7. Accelerating and focusing structures for PIGMI

    International Nuclear Information System (INIS)

    Swenson, D.A.; Bush, E.D. Jr.; Holsinger, R.F.; Manca, J.J.; Saito, N.; Stovall, J.E.

    1977-01-01

    The National Cancer Institute is supporting a program of accelerator development at the Los Alamos Scientific Laboratory aimed at the extension of proton linac technologies to produce the most suitable Pion Generator for Medical Irradiations (PIGMI). An optimized design of a pion generator suitable for a radiotherapy program at a major medical center has been established, consisting of a 250-keV injector, followed by a 35-meter-long drift-tube linac that accelerates the proton beam to 150 MeV, and an 85-meter-long coupled-cavity linac that accelerates the beam to its final energy of 650 MeV, where the average beam current of 100 microamperes impinges on one or more targets producing abundant quantities of π - mesons for radiotherapeutic applications. A number of extensions to proton linac technology are being pursued under the PIGMI program at LASL. A discussion is given of recent developments in three areas relevant to the acceleration and focusing of proton beams, namely, the alternating phase focused (APF) linac structure, the disk and washer linac structure, and small permanent magnet quadrupole lenses. The APF linac structure is being developed for the acceleration and focusing role from the injection energy of 250 keV to a few MeV, where a transition is made to a permanent magnet quadrupole focused linac structure. The disk and washer linac structure is under consideration for the high velocity portion of the design

  8. Gas ionization by focused laser beams

    International Nuclear Information System (INIS)

    Brito, A.L. de.

    1984-01-01

    It is shown that the effect of line broadening by focusing may considerably contribute to the observed laser-induced ionization of gases when the ionization energy of the gas molecules is well above the mean photon energy of the laser radiation. (Author) [pt

  9. Focal CT abnormality and epileptogenic focus

    International Nuclear Information System (INIS)

    Yagi, Kazuichi; Mihara, Tadahiro; Tottori, Takayasu; Matsuda, Kazumi; Watanabe, Yutaka; Seino, Masakazu

    1989-01-01

    In 31 patients with temporal lobe epilepsy, the precise site of epileptogenic focus was determined by means of a depth EEG recording as one of the presurgical evaluations. In 13 patients, a CT scan revealed focal lesions; 7 in the left temporal lobe and 6 in the right temporal lobe. In 5 of the 7 patients and in 5 of the 6 patients the epileptogenic foci were determined in the temporal lobe on the side of a CT lesion. However, in 2 of the patients with a CT lesion in the left temporal lobe, independent epileptogenic foci were found in both the temporal lobes, and in the other patient with a CT lesion in the right temporal lobe, they were found in the right frontal and left temporal lobes. Thus, the CT lesions agreed in lateralization and focality with the epileptogenic foci in 10 of the 13 patients (77%), but they disagreed in 3 (23%). A CT lesion disclosed in the temporal lobe does not necessarily indicate the side and/or site where the epileptogenic focus may be localized. Although exceptions may be made, spatial disagreement was exemplified between the CT lesion and epileptogenic focus. Therefore, extreme caution has to be taken on the side and/or site of the epileptogenic focus when functional surgical indication is to be made. (author)

  10. Proximity focusing RICH with TOF capabilities

    International Nuclear Information System (INIS)

    Korpar, S.; Adachi, I.; Fujita, K.; Fukushima, T.; Gorisek, A.; Hayashi, D.; Iijima, T.; Ikado, T.; Ishikawa, T.; Kawai, H.; Kozakai, Y.; Krizan, P.; Kuratani, A.; Mazuka, Y.; Nakagawa, T.; Nishida, S.; Ogawa, S.; Pestotnik, R.; Seki, T.; Sumiyoshi, T.; Tabata, M.; Unno, Y.

    2007-01-01

    A proximity focusing RICH counter with a multi-channel micro-channel plate (MCP) PMT was tested as a time-of-flight counter. Cherenkov photons emitted in the radiator medium as well as in the entrance window of the PMT were used for the time-of-flight measurement, and an excellent performance of the counter could be demonstrated

  11. Fundamental Movement Skills: An Important Focus

    Science.gov (United States)

    Barnett, Lisa M.; Stodden, David; Cohen, Kristen E.; Smith, Jordan J.; Lubans, David Revalds; Lenoir, Matthieu; Iivonen, Susanna; Miller, Andrew D.; Laukkanen, Arto; Dudley, Dean; Lander, Natalie J.; Brown, Helen; Morgan, Philip J.

    2016-01-01

    Purpose: Recent international conference presentations have critiqued the promotion of fundamental movement skills (FMS) as a primary pedagogical focus. Presenters have called for a debate about the importance of, and rationale for teaching FMS, and this letter is a response to that call. The authors of this letter are academics who actively…

  12. Shape from focus for large image fields

    Czech Academy of Sciences Publication Activity Database

    Pavlíček, Pavel; Hamarová, Ivana

    2015-01-01

    Roč. 54, č. 33 (2015), s. 9747-9751 ISSN 1559-128X R&D Projects: GA ČR GA13-12301S Institutional support: RVO:68378271 Keywords : shape from focus * large image fields * optically rough surface Subject RIV: BH - Optics , Masers, Lasers Impact factor: 1.598, year: 2015

  13. X-ray focusing using capillary arrays

    International Nuclear Information System (INIS)

    Nugent, K.A.; Chapman, H.N.

    1990-01-01

    A new form of X-ray focusing device based on glass capillary arrays is presented. Theoretical and experimental results for array of circular capillaries and theoretical and computational results for square hole capillaries are given. It is envisaged that devices such as these will find wide applications in X-ray optics as achromatic condensers and collimators. 3 refs., 4 figs

  14. SERPUKHOV: Focusing particles by a crystal

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    With several Laboratories having shown how bent crystals can be used to steer particle beams, a team working at the Institute for High Energy Physics (IHEP) at Serpukhov, near Moscow, has shown how these crystals can also be used to focus particle beams

  15. Optimizing Monochromatic Focusing on ThALES

    Czech Academy of Sciences Publication Activity Database

    Čermák, P.; Boehm, M.; Kulda, J.; Roux, S.; Hiess, A.; Steffens, P.; Šaroun, Jan

    2014-01-01

    Roč. 82, A (2014), SA026 ISSN 0031-9015 Institutional support: RVO:61389005 Keywords : Monte Carlo ray-tracing * inelastic neutron scattering * Triple-Axis spectrometer * monochromatic focusing Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.585, year: 2014

  16. Revitalize Electrical Program with Renewable Energy Focus

    Science.gov (United States)

    Karns, Robert J.

    2012-01-01

    Starting a renewable energy technology (RET) program can be as simple as shifting the teaching and learning focus of a traditional electricity program toward energy production and energy control systems. Redirecting curriculum content and delivery to address photovoltaic solar (PV solar) technology and small wind generation systems is a natural…

  17. Capability, Governance and Nanotechnology : Focus on India ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nanotechnology is the study and manipulation of matter on an ultra-small scale, generally in the range of 1-100 nanometres (1 metre = 1 billion nanometres). Like biotechnology, nanotechnology has the potential to bring huge benefits to the poor, but also huge costs. Focusing on India, this project will examine the ...

  18. Summary report on focusing HTGR technology programs

    International Nuclear Information System (INIS)

    The program effort to focus technology development activities consists of work in three areas: the identification of Reference Plant Options; the identification of design data needs and supporting program requirements for these plants; and the development of management plans and tools consistent with the execution of candidate systems

  19. Beam acceleration in plasma focus device

    Energy Technology Data Exchange (ETDEWEB)

    Antanasijevic, R.; Banjanac, R.; Dragic, A.; Maric, Z.; Stanojevic, J.; Udovicic, V. E-mail: udovicic@atom.phy.bg.ac.yu; Vukovic, J

    2001-06-01

    The proton beam emission from the small 8 kJ plasma focus device operated with the H{sub 2} filling was analyzed. Maximum energy and yield were obtained using NTD. The fast protons were registered with the energy up to 500 keV using the polycarbonate absorbers with the different thickness.

  20. Beam acceleration in plasma focus device

    International Nuclear Information System (INIS)

    Antanasijevic, R.; Banjanac, R.; Dragic, A.; Maric, Z.; Stanojevic, J.; Udovicic, V.; Vukovic, J.

    2001-01-01

    The proton beam emission from the small 8 kJ plasma focus device operated with the H 2 filling was analyzed. Maximum energy and yield were obtained using NTD. The fast protons were registered with the energy up to 500 keV using the polycarbonate absorbers with the different thickness

  1. Welcome Families by Focusing on Strengths

    Science.gov (United States)

    Minkel, Justin

    2017-01-01

    Families of struggling students, this teacher in a high-poverty school knows, feel defensive and hurt when communications with their child's school focus mainly on that child's deficits. This is especially true for families from poverty or immigrant backgrounds--and affirming the latter families is important in the current climate of hostility…

  2. Invited paper: Plasma focus in China

    International Nuclear Information System (INIS)

    Jinji, Y.

    1983-01-01

    Plasma focus research in China began in the seventies. There are now 3 devices in two institutions, Tsinghua University in Beijing and the Institute of Mining and Metallurgy in Changsha. The research works can be divided into two groups: the engineering problems related to plasma focus devices and the plasma phenomena and process of the focus. Under the first subject, insulation and plasma spark gaps are studied. By casting silicon rubber onto the ends of the transmission cable, the length of insulation can be appreciably reduced. With the method of simulating charges, the electric field distribution of a field distortion type spark gap was calculated. Comparison of the field distribution before and after triggering was represented. It shows that the electric field strength of the gap after triggering may reach 14-80 times as high as that before triggering. Thus the characteristic of the gap may be improved remarkably. In respect of the phenomena of the plasma focus, neutron emission and X-ray emission were measured. It was shown that the proportion of X-ray with higher energy depends upon the material of the inner electrode. Two kinds of stud materials, tungsten and molybendum, were adopted. Measured results of the distribution of X-ray energy were represented respectively for the two materials used. Evidently, the distribution changed with the inserted materials

  3. Organisational Change: A Solution-Focused Approach

    Science.gov (United States)

    Morgan, Gavin

    2016-01-01

    This study investigates the effectiveness of a solution-focused approach to organisational change. Planning Alternative Tomorrows with Hope (PATH) is an intervention more commonly applied to individuals. In this study the intervention is used with groups of people working in educational organisations to help manage the change process. The approach…

  4. Professional Development: Focusing on Transition. Issue Brief

    Science.gov (United States)

    de Azúa, Ramón L.; Keleher, Julia

    2017-01-01

    In 2017, the National Technical Assistance Center for the Education of Neglected or Delinquent Children and Youth (NDTAC) released its first in a series of professional development briefs that focus on the professional development needs and interests of Neglected or Delinquent (N or D) State coordinators, correctional educators, and providers of…

  5. Synthesis of focusing-and-deflection columns

    International Nuclear Information System (INIS)

    Szilagyi, M.; Mui, P.H.

    1995-01-01

    Szilagyi and Szep have demonstrated that focusing lenses of high performances can be constructed from a column of circular plate electrodes. Later, Szilagyi modified that system to include dipole, quadrupole, and octupole components by partitioning each plate into eight equal sectors. It has already been shown that the additional quadrupole components can indeed bring about substantial improvements in the focusing of charged particle beams. In this article, that design procedure is expanded to construct columns capable of both focusing and deflecting particle beams by just introducing additional dipole components. In this new design, the geometry of the system remains unchanged. The only extra complication is the demand for more individual controls of the sector voltages. Two sample designs, one for negative ions and one for electrons, are presented showing that in both cases a ±2.3 mrad diverging beam can be focused down to a spot of less than 50 nm in radius over a scanning circular area of radius 0.25 mm. The details of the two systems are given in Sec. IV along with the source conditions. The performance of the negative ion system is found to be comparable to the published data. For the relativistic electron system, the interaction of individual components to reduce various aberrations is investigated. copyright 1995 American Vacuum Society

  6. Focus: Composition and Language Study, K-6.

    Science.gov (United States)

    Stewart, Donald, Ed.

    1974-01-01

    This issue of "Kansas English" focus on composition and language study, kindergarten through grade six. The articles and authors are "Evaluating Process and Product in Children's Writing" by Robert L. Hillerich, "Written Language Development and Instruction of Elementary School Children" by Lester S. Golub, "From a Reading Desk" by Myrline…

  7. Computational numerical modelling of plasma focus

    International Nuclear Information System (INIS)

    Brollo, Fabricio

    2005-01-01

    Several models for calculation of the dynamics of Plasma Focus have been developed. All of them begin from the same physic principle: the current sheet run down the anode length, ionizing and collecting the gas that finds in its way.This is known as snow-plow model.Concerning pinch's compression, a MHD model is proposed.The plasma is treated as a fluid , particularly as a high ionized gas.However, there are not many models that, taking into account thermal equilibrium inside the plasma, make approximated calculations of the maximum temperatures reached in the pinch.Besides, there are no models which use those temperatures to estimate the termofusion neutron yield for the Deuterium or Deuterium-Tritium gas filled cases.In the PLADEMA network (Dense Magnetized Plasmas) a code was developed with the objective of describe the plasma focus dynamics, in a conceptual engineering stage.The codes calculates the principal variables (currents, time to focus, etc) and estimates the neutron yield in Deuterium-filled plasma focus devices.It can be affirmed that the code's experimental validation, in its axial and radial stages, was very successfully. However, it was accepted that the compression stage should be formulated again, to find a solution for a large variation of a parameter related with velocity profiles for the particles trapped inside the pinch.The objectives of this work can be stated in the next way : - Check the compression's model hypothesis. Develop a new model .- Implement the new model in the code. Compare results against experimental data of Plasma Focus devices from all around the world [es

  8. New Office Software course format!

    CERN Multimedia

    HR Department

    Always keen to anticipate your  training needs, the Technical Training service is pleased to propose two new Office Software course formats: “Focus on... ”:  On a monthly basis we will propose a theme such as “Sharepoint Collaboration Workspace” or “Word 2007” or “charts”, etc.  You will be invited to send us in advance your questions regarding the proposed topic and register  for the course through our Training Catalogue. During the session, our trainer will answer all the questions received and participants will increase their knowledge thanks to the solutions discussed for everyone. The course will last two hours, from 9-00 to 11-00 a.m. - with open questions on the proposed topic at the end.   “Office software Individual coaching”: If one or more specific topics are causing you sleepless nights, you can get the help of our trainer who will ...

  9. New Office Software course format!

    CERN Multimedia

    HR Department

    2009-01-01

    Always keen to anticipate your  training needs, the Technical Training service is pleased to propose two new Office Software course formats: “Focus on... ”:  On a monthly basis we will propose a theme such as “Sharepoint Collaboration Workspace” or “Word 2007” or “charts”, etc.  You will be invited to send us in advance your questions regarding the proposed topic and register  for the course through our Training Catalogue. During the session, our trainer will answer all the questions received and participants will increase their knowledge thanks to the solutions discussed for everyone. The course will last two hours, from 9-00 to 11-00 a.m. - with open questions on the proposed topic at the end.   “Office software Individual coaching”: If one or more specific topics are causing you sleepless nights, you can get the help of our trainer who will ...

  10. Fracturing of subterranean formations

    Energy Technology Data Exchange (ETDEWEB)

    Kiel, O.M.; Kidwell, A.L.

    1968-03-19

    This method of propping fractured formations results in high conductivities. In the method, certain naturally occurring crystals are used as propping agents. Suitable crystals include garnet, corundum, zircon, rutile, high-temperature quartz, and other minerals which have Moh's hardness values of about 6 or greater and weather out as individual crystals of about 40 mesh or larger. These are said to result in permeabilities significantly higher than those obtained with ordinary quartz sand, metallic shot, glass beads, plastic particles, walnut hulls, or similar materials. (10 claims)

  11. Situated Formative Feedback

    DEFF Research Database (Denmark)

    Lukassen, Niels Bech; Wahl, Christian; Sorensen, Elsebeth Korsgaard

    refer to this type of feedback as, Situated Formative Feedback (SFF). As a basis for exploring, identifying and discussing relevant aspects of SFF the paper analyses qualitative data from a Moodle dialogue. Data are embedded in the qualitative analytic program Nvivo and are analysed with a system...... theoretical textual analysis method. Asynchronous written dialogue from an online master’s course at Aalborg University forms the empirical basis of the study. The findings suggests in general that students play an essential role in SFF and that students and educators are equal in the COP, but holds different...

  12. Superclusters and galaxy formation

    Energy Technology Data Exchange (ETDEWEB)

    Einasto, J; Joeveer, M; Saar, E [Tartu Astrophysical Observatory, Toravere, Estonia (USSR)

    1980-01-03

    A study of the structure of superclusters in the Southern galactic hemisphere using Zwicky clusters as principal tracers of the large-scale structure of the Universe is reported. The data presented suggest that the formation of galaxies was a two stage process involving larger spatial dimensions than earlier workers have postulated. In the first stage proto-superclusters and big holes had to form from the non-dissipative dark matter while in the second hot gas, by cooling and settling down into the potential wells caused by dark matter, will form galaxies and clusters of galaxies.

  13. EDITORIAL: Focus on Micro- and Nanofluidics FOCUS ON MICRO- AND NANOFLUIDICS

    Science.gov (United States)

    Ajdari, Armand; Stone, Howard A.

    2009-07-01

    This focus issue of New Journal of Physics concentrates on recent developments in microfluidics, and related small-scale flow themes. This subject touches on many areas with the common element that they are engaged with understanding, measuring or manipulating flows at the scale of a few hundred microns or smaller. Microfluidics is of interest to many scientists and engineers from many disciplines because it is a toolbox from which they can investigate basic questions in their respective fields. In particular, the field has led to new studies of small-scale fluid flows, especially those dominated by surface effects, which is crucial for understanding electrokinetics, chemical reactions and phase changes, and multiphase systems, including those involving dispersed liquid and gas phases, suspended particles, cells, vesicles, capsules, etc. The lower length scale of these kinds of flows concerns nanoscale manipulation of objects such as DNA or nanoparticles, nanofabrication of surfaces, studies of the flow within nanometers of substrates, etc. Microfluidics has also given rise to technologies because it enables design and implementation of new devices for sensing, detection, measurement, materials characterization, combinatorial discovery, cellular-scale manipulation, miniaturization of reactors, etc. The fact that these systems are small, cheap, physically flexible, portable, multifunctional, and, when they are working, produce measurements quickly, offers many new avenues for innovation. In this issue we highlight contributions from around the world that explore research directions inspired by the manifold possibilities of microfluidics. In particular, the papers include reports of single-phase flows that are driven by electrical fields, so-called electrokinetics. Although the field has its origins in the 19th century, if not even earlier, new theoretical ideas are required to understand dynamics close to charged surfaces, and new applications of the basic ideas are

  14. Concept formation knowledge and experience in unsupervised learning

    CERN Document Server

    Fisher, Douglas H; Langley, Pat

    1991-01-01

    Concept Formation: Knowledge and Experience in Unsupervised Learning presents the interdisciplinary interaction between machine learning and cognitive psychology on unsupervised incremental methods. This book focuses on measures of similarity, strategies for robust incremental learning, and the psychological consistency of various approaches.Organized into three parts encompassing 15 chapters, this book begins with an overview of inductive concept learning in machine learning and psychology, with emphasis on issues that distinguish concept formation from more prevalent supervised methods and f

  15. Numerical experimentation on focusing time and neutron yield in GN1 plasma focus machine

    International Nuclear Information System (INIS)

    Singh, Arwinder; Lee, Sing; Saw, S.H.

    2014-01-01

    In this paper, we have shown how we have fitted Lee's six phase model code to analyze the current waveform of the GN1 plasma focus machine working in deuterium gas. The Lee's 6-phase model codes was later configured to work between 0.5 to 6 Torr and the results of both focusing time and neutron yield was then compared with the published experimental results. The final results indicate that Lee's code, gives realistic plasma dynamics and focus properties together with a realistic neutron yield for GN1 plasma focus, without the need of any adjustable parameters, needing only to fit the computed current trace to a measured current trace. (author)

  16. The COSPIX Mission: Focusing on the Energetic and Obscured Universe

    Science.gov (United States)

    Ferrando, P.; Goldwurm, A.; Laurent, P.; Limousin, O.; Beckmann, V; Arnaud, M.; Barcons, X.; Bomans, D.; Caballero, I.; Carrera, F.; hide

    2010-01-01

    Tracing the formation and evolution of all supermassive black holes, including the obscured ones, understanding how black holes influence their surroundings and how matter behaves under extreme conditions, are recognized as key science objectives to be addressed by the next generation of instruments. These are the main goals of the COSPIX proposal, made to ESA in December 2010 in the context of its call for selection of the M3 mission. In addition, COSPIX, will also provide key measurements on the non thermal Universe, particularly in relation to the question of the acceleration of particles, as well as on many other fundamental questions as for example the energetic particle content of clusters of galaxies. COSPIX is proposed as an observatory operating from 0.3 to more than 100 keV. The payload features a single long focal length focusing telescope offering an effective area close to ten times larger than any scheduled focusing mission at 30 keV, an angular resolution better than 20 arcseconds in hard X-rays, and polarimetric capabilities within the same focal plane instrumentation. In this paper, we describe the science objectives of the mission, its baseline design, and its performances, as proposed to ESA.

  17. Focus group interview: an underutilized research technique for improving theory and practice in health education.

    Science.gov (United States)

    Basch, C E

    1987-01-01

    The purpose of this article is to increase awareness about and stimulate interest in using focus group interviews, a qualitative research technique, to advance the state-of-the-art of education and learning about health. After a brief discussion of small group process in health education, features of focus group interviews are presented, and a theoretical framework for planning a focus group study is summarized. Then, literature describing traditional and health-related applications of focus group interviews is reviewed and a synthesis of methodological limitations and advantages of this technique is presented. Implications are discussed regarding: need for more inductive qualitative research in health education; utility of focus group interviews for research and for formative and summative evaluation of health education programs; applicability of marketing research to understanding and influencing consumer behavior, despite notable distinctions between educational initiatives and marketing; and need for professional preparation faculty to consider increasing emphasis on qualitative research methods.

  18. Formation of planetary systems

    International Nuclear Information System (INIS)

    Brahic, A.

    1982-01-01

    It seemed appropriate to devote the 1980 School to the origin of the solar system and more particularly to the formation of planetary systems (dynamic accretion processes, small bodies, planetary rings, etc...) and to the physics and chemistry of planetary interiors, surface and atmospheres (physical and chemical constraints associated with their formation). This Summer School enabled both young researchers and hard-nosed scientists, gathered together in idyllic surroundings, to hold numerous discussions, to lay the foundations for future cooperation, to acquire an excellent basic understanding, and to make many useful contacts. This volume reflects the lectures and presentations that were delivered in this Summer School setting. It is aimed at both advanced students and research workers wishing to specialize in planetology. Every effort has been made to give an overview of the basic knowledge required in order to gain a better understanding of the origin of the solar system. Each article has been revised by one or two referees whom I would like to thank for their assistance. Between the end of the School in August 1980 and the publication of this volume in 1982, the Voyager probes have returned a wealth of useful information. Some preliminary results have been included for completeness

  19. A Mesoproterozoic iron formation

    Science.gov (United States)

    Canfield, Donald E.; Zhang, Shuichang; Wang, Huajian; Wang, Xiaomei; Zhao, Wenzhi; Su, Jin; Bjerrum, Christian J.; Haxen, Emma R.; Hammarlund, Emma U.

    2018-04-01

    We describe a 1,400 million-year old (Ma) iron formation (IF) from the Xiamaling Formation of the North China Craton. We estimate this IF to have contained at least 520 gigatons of authigenic Fe, comparable in size to many IFs of the Paleoproterozoic Era (2,500–1,600 Ma). Therefore, substantial IFs formed in the time window between 1,800 and 800 Ma, where they are generally believed to have been absent. The Xiamaling IF is of exceptionally low thermal maturity, allowing the preservation of organic biomarkers and an unprecedented view of iron-cycle dynamics during IF emplacement. We identify tetramethyl aryl isoprenoid (TMAI) biomarkers linked to anoxygenic photosynthetic bacteria and thus phototrophic Fe oxidation. Although we cannot rule out other pathways of Fe oxidation, iron and organic matter likely deposited to the sediment in a ratio similar to that expected for anoxygenic photosynthesis. Fe reduction was likely a dominant and efficient pathway of organic matter mineralization, as indicated by organic matter maturation by Rock Eval pyrolysis combined with carbon isotope analyses: Indeed, Fe reduction was seemingly as efficient as oxic respiration. Overall, this Mesoproterozoic-aged IF shows many similarities to Archean-aged (>2,500 Ma) banded IFs (BIFs), but with an exceptional state of preservation, allowing an unprecedented exploration of Fe-cycle dynamics in IF deposition.

  20. Endocytosis and Enamel Formation

    Directory of Open Access Journals (Sweden)

    Cong-Dat Pham

    2017-07-01

    Full Text Available Enamel formation requires consecutive stages of development to achieve its characteristic extreme mineral hardness. Mineralization depends on the initial presence then removal of degraded enamel proteins from the matrix via endocytosis. The ameloblast membrane resides at the interface between matrix and cell. Enamel formation is controlled by ameloblasts that produce enamel in stages to build the enamel layer (secretory stage and to reach final mineralization (maturation stage. Each stage has specific functional requirements for the ameloblasts. Ameloblasts adopt different cell morphologies during each stage. Protein trafficking including the secretion and endocytosis of enamel proteins is a fundamental task in ameloblasts. The sites of internalization of enamel proteins on the ameloblast membrane are specific for every stage. In this review, an overview of endocytosis and trafficking of vesicles in ameloblasts is presented. The pathways for internalization and routing of vesicles are described. Endocytosis is proposed as a mechanism to remove debris of degraded enamel protein and to obtain feedback from the matrix on the status of the maturing enamel.

  1. Magnetic focusing in triangular electron billiards

    DEFF Research Database (Denmark)

    Bøggild, Peter; Kristensen, A.; Lindelof, Poul Erik

    1999-01-01

    The classical ballistic magnetotransport in triangular electron billiards fabricated in a high mobility GaAs heterostructure has been studied at 4.2 K. The sample geometry may be viewed as a double-slit structure with a skewed injection angle. We observe a striking cancellation of the magnetic...... focusing spectrum compared to the case of a perpendicular injection angle. From numerical and analytical analysis, we confirm that the quenching is a fundamental geometrical effect, and identify two mechanisms responsible for the anomaly. The focusing spectrum of the considered skewed geometry...... is remarkably sensitive to the angular distribution of injected electrons as well as the overall injection angle. [S0163-1829(99)06619-9]....

  2. Plasma devices for focusing extreme light pulses

    International Nuclear Information System (INIS)

    Fuchs, J.; Gonoskov, A.A.; Nakatsutsumi, M.; Nazarov, W.; Quere, F.; Sergeev, A.M.; Yan, X.Q.

    2014-01-01

    Since the inception of the laser, there has been a constant push toward increasing the laser peak intensity, as this has lead to opening the exploration of new territories, and the production of compact sources of particles and radiation with unprecedented characteristics. However, increasing the peak laser intensity is usually performed by enhancing the produced laser properties, either by lowering its duration or increasing its energy, which involves a great level of complexity for the laser chain, or comes at great cost. Focusing tightly is another possibility to increase the laser intensity, but this comes at the risk of damaging the optics with target debris, as it requires their placement in close proximity to the interaction region. Plasma devices are an attractive, compact alternative to tightly focus extreme light pulses and further increase the final laser intensity. (authors)

  3. Dense plasma focus - a literature review

    International Nuclear Information System (INIS)

    Tendys, J.

    1976-01-01

    The dense plasma focus (DPF) is a convenient source of short, intense neutron pulses, and dense, high temperature plasma. This review of the literature on the DPF indicates that its operation is still not understood, and attempts to show where the present data is either inadequate or inconsistent. Because the plasma conditions and neutron and x-ray fluxes vary from shot to shot, it is maintained that, to resolve inconsistencies in the present data, spectra need to be measured with energy and time resolution simultaneously, and cannot be built up from a large number of shots. Time resolutions of the order of 1 nsec for pulse lengths of about 100 nsec make these requirements especially difficult. Some theoretical models are presented for the neutron output and its spectrum, but no self-consistent description of the plasma in the focus region is likely for some time. (author)

  4. Missing data imputation: focusing on single imputation.

    Science.gov (United States)

    Zhang, Zhongheng

    2016-01-01

    Complete case analysis is widely used for handling missing data, and it is the default method in many statistical packages. However, this method may introduce bias and some useful information will be omitted from analysis. Therefore, many imputation methods are developed to make gap end. The present article focuses on single imputation. Imputations with mean, median and mode are simple but, like complete case analysis, can introduce bias on mean and deviation. Furthermore, they ignore relationship with other variables. Regression imputation can preserve relationship between missing values and other variables. There are many sophisticated methods exist to handle missing values in longitudinal data. This article focuses primarily on how to implement R code to perform single imputation, while avoiding complex mathematical calculations.

  5. Plasma focus system: Design, construction and experiments

    International Nuclear Information System (INIS)

    Alacakir, A.; Akguen, Y.; Boeluekdemir, A. S.

    2007-01-01

    The aim of this work is to construct a compact experimental system for fusion research. The design, construction and experiments of the 3 kJ Mather type plasma focus machine is described. This machine is established for neutron yield and fast neutron radiography by D-D reaction which is given by D + D→ 3 He (0.82 MeV) + n (2.45 MeV) . Investigation of the geometry of plasma focus machine in the presence of high voltage drive and vacuum system setup is shown. 108 neutron per pulse and 200 kA peak current is obtained for many shots. Scintillator screen for fast neutron imaging, sensitive to 2.45 MeV neutrons, is also manufactured in our labs. Structural neutron shielding computations for safety is also completed

  6. Compression Models for Plasma Focus Devices

    International Nuclear Information System (INIS)

    Gonzalez, Jose; Calusse, Alejandro; Ramos, Ruben; Rodriguez Palomino, Luis

    2003-01-01

    Using a numerical model that calculates the dynamics of Plasma Focus devices, we compared the results of three different compression models of the plasma pinch.One of the main objectives in this area is to develop a simplified model to calculate the neutron production of Plasma Focus devices, to study the influence of the main parameters in this neutron yield.The dynamics is thoroughly studied, and the model predicts fairly well values such as maximum currents and times for pinch collapse.Therefore, we evaluate here different models of pinch compression, to try to predict the neutron production with good agreement with the rest of the variables involved.To fulfill this requirement, we have experimental results of neutron production as a function of deuterium filling pressure in the chamber, and typical values of other main variables in the dynamics of the current sheet

  7. Slice through an LHC focusing magnet

    CERN Multimedia

    Slice through an LHC superconducting quadrupole (focusing) magnet. The slice includes a cut through the magnet wiring (niobium titanium), the beampipe and the steel magnet yokes. Particle beams in the Large Hadron Collider (LHC) have the same energy as a high-speed train, squeezed ready for collision into a space narrower than a human hair. Huge forces are needed to control them. Dipole magnets (2 poles) are used to bend the paths of the protons around the 27 km ring. Quadrupole magnets (4 poles) focus the proton beams and squeeze them so that more particles collide when the beams’ paths cross. Bringing beams into collision requires a precision comparable to making two knitting needles collide, launched from either side of the Atlantic Ocean.

  8. Self-focusing of whistler waves

    Science.gov (United States)

    Karpman, V. I.; Kaufman, R. N.; Shagalov, A. G.

    1992-01-01

    The theory of axially symmetric self-focusing of whistler waves, based on the full system of Maxwell equations, is developed. The plasma is described by the magnetohydrodynamic equations including the ponderomotive force from RF field. The nonlinear Schrodinger equations (NSE) for arbitrary azimuthal modes of whistler waves are derived. It is shown that they differ from the NSE for a scalar field; this is connected with an intrinsic angular momentum due to the rotating polarization of whistlers. It is shown that the self-focusing, as described by the NSE, differs in its final stage from the results following the full set of Maxwell equations. The latter gives defocusing after sufficient narrowing of the initial wave beam, due to transformation of the trapped wave into a nontrapped branch which is not contained in the NSE description. The oscillatory character of the defocusing is demonstrated.

  9. Raman Amplification with a Flying Focus

    Science.gov (United States)

    Turnbull, D.; Bucht, S.; Davies, A.; Haberberger, D.; Kessler, T.; Shaw, J. L.; Froula, D. H.

    2018-01-01

    We propose a new laser amplifier scheme utilizing stimulated Raman scattering in plasma in conjunction with a "flying focus"—a chromatic focusing system combined with a chirped pump beam that provides spatiotemporal control over the pump's focal spot. Pump intensity isosurfaces are made to propagate at v =-c so as to be in sync with the injected counterpropagating seed pulse. By setting the pump intensity in the interaction region to be just above the ionization threshold of the background gas, an ionization wave is produced that travels at a fixed distance ahead of the seed. Simulations show that this will make it possible to optimize the plasma temperature and mitigate many of the issues that are known to have impacted previous Raman amplification experiments, in particular, the growth of precursors.

  10. Self-focusing in SF6

    International Nuclear Information System (INIS)

    Ackerhalt, J.R.; Galbraith, H.W.

    1981-01-01

    It is shown by explicit calculation of previously published quasicontinuum model that the molecular susceptibility rapidly approaches zero as higher excited states of the molecule become populated. Hence the overtones of the ν 3 -pumped mode are totally responsible for the self focusing effects in SF 6 . The ν 3 ladder contribution to the susceptibility is calculated. The vibrational model is a classical triply degenerate anharmonic oscillator in the Cartesian basis with the anharmonicity parameters chosen to be consistent with the latest spectroscopic analysis of the 3ν 3 overtone spectrum. The rotational structure is represented by a distribution of these oscillators where the distribution is chosen to correspond to the spectrum of the ν 3 fundamental. Good agreement is found with the 300 0 in self-focusing data of Nowak and Ham at CO 2 P(28), P(20) and P(10) in SF 6

  11. Focused-laser interferometric position sensor

    International Nuclear Information System (INIS)

    Friedman, Stephen J.; Barwick, Brett; Batelaan, Herman

    2005-01-01

    We describe a simple method to measure the position shifts of an object with a range of tens of micrometers using a focused-laser (FL) interferometric position sensor. In this article we examine the effects of mechanical vibration on FL and Michelson interferometers. We tested both interferometers using vibration amplitudes ranging from 0 to 20 μm. Our FL interferometer has a resolution much better than the diffraction grating periodicities of 10 and 14 μm used in our experiments. A FL interferometer provides improved mechanical stability at the expense of spatial resolution. Our experimental results show that Michelson interferometers cannot be used when the vibration amplitude is more than an optical wavelength. The main purpose of this article is to demonstrate that a focused-laser interferometric position sensor can be used to measure the position shifts of an object on a less sensitive, micrometer scale when the vibration amplitude is too large to use a Michelson interferometer

  12. Radio frequency focused interdigital linear accelerator

    Science.gov (United States)

    Swenson, Donald A.; Starling, W. Joel

    2006-08-29

    An interdigital (Wideroe) linear accelerator employing drift tubes, and associated support stems that couple to both the longitudinal and support stem electromagnetic fields of the linac, creating rf quadrupole fields along the axis of the linac to provide transverse focusing for the particle beam. Each drift tube comprises two separate electrodes operating at different electrical potentials as determined by cavity rf fields. Each electrode supports two fingers, pointing towards the opposite end of the drift tube, forming a four-finger geometry that produces an rf quadrupole field distribution along its axis. The fundamental periodicity of the structure is equal to one half of the particle wavelength .beta..lamda., where .beta. is the particle velocity in units of the velocity of light and .lamda. is the free space wavelength of the rf. Particles are accelerated in the gaps between drift tubes. The particle beam is focused in regions inside the drift tubes.

  13. Star Formation in Irregular Galaxies.

    Science.gov (United States)

    Hunter, Deidre; Wolff, Sidney

    1985-01-01

    Examines mechanisms of how stars are formed in irregular galaxies. Formation in giant irregular galaxies, formation in dwarf irregular galaxies, and comparisons with larger star-forming regions found in spiral galaxies are considered separately. (JN)

  14. Standard exercise report format (SERF)

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    This talk summarizes the reasons for the development of draft SERF the Standard Exercise Report Format used for reporting the results of emergency preparedness exercises, and gives a summary of the format and rational behind it

  15. Messenger RNA 3' end formation in plants.

    Science.gov (United States)

    Hunt, A G

    2008-01-01

    Messenger RNA 3' end formation is an integral step in the process that gives rise to mature, translated messenger RNAs in eukaryotes. With this step, a pre-messenger RNA is processed and polyadenylated, giving rise to a mature mRNA bearing the characteristic poly(A) tract. The poly(A) tract is a fundamental feature of mRNAs, participating in the process of translation initiation and being the focus of control mechanisms that define the lifetime of mRNAs. Thus messenger RNA 3' end formation impacts two steps in mRNA biogenesis and function. Moreover, mRNA 3' end formation is something of a bridge that integrates numerous other steps in mRNA biogenesis and function. While the process is essential for the expression of most genes, it is also one that is subject to various forms of regulation, such that both quantitative and qualitative aspects of gene expression may be modulated via the polyadenylation complex. In this review, the current status of understanding of mRNA 3' end formation in plants is discussed. In particular, the nature of mRNA 3' ends in plants is reviewed, as are recent studies that are beginning to yield insight into the functioning and regulation of plant polyadenylation factor subunits.

  16. Epileptogenic focus localization: a new approach

    Energy Technology Data Exchange (ETDEWEB)

    Tavares, Vânia [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa (Portugal); Ribeiro, André Santos [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa (Portugal); Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London (United Kingdom); Capela, Carlos; Cerqueira, Luís [Department of Neuroradiology, Centro Hospitalar Lisboa Central, Lisbon (Portugal); Ferreira, Hugo Alexandre [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa (Portugal)

    2015-05-18

    Epilepsy is one of the most important chronic neurological disorders worldwide affecting more than 50 million people of all ages. Among these, almost 20% of epilepsy cases are uncontrollable and have an unknown source of this abnormal electrical activity. Present techniques for the detection of epileptogenic foci include electroencephalography (EEG), positron emission tomography, and multimodal EEG/functional magnetic resonance imaging (fMRI), all with limitations in terms of spatial and temporal resolutions. In order to overcome some of those limitations a novel approach using fMRI alone was developed based on the hypotheses that the epileptogenic focus shows Blood Oxygen Level Dependent (BOLD) temporal profiles distinct from the remaining brain parenchyma during interictal activity and that the epileptogenic focus BOLD signals show lower complexity than healthy parenchyma. In this novel approach, bi-dimensional temporal clustering analysis, a data-driven technique, was used to identify brain regions with similar temporal profiles. Then, the BOLD signals of these regions were assessed regarding complexity using detrended fluctuation analysis and also using a modified multiscale entropy algorithm in order to identify which of those regions corresponded to epileptogenic tissue. In order to demonstrate the applicability of the developed method three epileptic patients were analyzed comprising two types of epilepsy: unilateral and bilateral temporal lobe epilepsies. The results showed that this method is able to detect the brain regions associated with epileptogenic tissue. The results also showed that the epileptogenic focus influences the dynamics of related brain networks. This could be a key factor in the applicability of this method to other epilepsy cases. Finally, new perspectives are envisioned concerning the use of this method in the medical care of epilepsy. In particular, by improving this method using simultaneous structural, functional, and metabolic

  17. New focusing analyser on IN12

    International Nuclear Information System (INIS)

    Schmidt, W.; Faak, B.

    1999-01-01

    Among several improvements and modifications the IN12 three-axis spectrometer for cold neutrons has been equipped with a new graphite analyzer with variable horizontal and fixed vertical focusing features. With this analyzer we could drastically improve the instrument performance and also meet the standards of a modern three-axis spectrometer. In this report we show construction details as well as experimental results which demonstrate the improvements. (author)

  18. SCIENTIFIC COMMUNICATION WITH A FOCUS ON SESAME

    CERN Document Server

    ahmad, sameem

    2017-01-01

    Scientific communication, the representation of CERN and raising awareness about science to a wide range of audiences is very important for the CERN communication teams. Having a physics background and an interest in science administration, communication and research, I was based in the International Relations sector, working in various groups and focusing on written communication. I gained experience in many aspects of scientific communications by finding out how CERN in represented in the press and media, other online forums and in outreach.

  19. Epileptogenic focus localization: a new approach

    International Nuclear Information System (INIS)

    Tavares, Vânia; Ribeiro, André Santos; Capela, Carlos; Cerqueira, Luís; Ferreira, Hugo Alexandre

    2015-01-01

    Epilepsy is one of the most important chronic neurological disorders worldwide affecting more than 50 million people of all ages. Among these, almost 20% of epilepsy cases are uncontrollable and have an unknown source of this abnormal electrical activity. Present techniques for the detection of epileptogenic foci include electroencephalography (EEG), positron emission tomography, and multimodal EEG/functional magnetic resonance imaging (fMRI), all with limitations in terms of spatial and temporal resolutions. In order to overcome some of those limitations a novel approach using fMRI alone was developed based on the hypotheses that the epileptogenic focus shows Blood Oxygen Level Dependent (BOLD) temporal profiles distinct from the remaining brain parenchyma during interictal activity and that the epileptogenic focus BOLD signals show lower complexity than healthy parenchyma. In this novel approach, bi-dimensional temporal clustering analysis, a data-driven technique, was used to identify brain regions with similar temporal profiles. Then, the BOLD signals of these regions were assessed regarding complexity using detrended fluctuation analysis and also using a modified multiscale entropy algorithm in order to identify which of those regions corresponded to epileptogenic tissue. In order to demonstrate the applicability of the developed method three epileptic patients were analyzed comprising two types of epilepsy: unilateral and bilateral temporal lobe epilepsies. The results showed that this method is able to detect the brain regions associated with epileptogenic tissue. The results also showed that the epileptogenic focus influences the dynamics of related brain networks. This could be a key factor in the applicability of this method to other epilepsy cases. Finally, new perspectives are envisioned concerning the use of this method in the medical care of epilepsy. In particular, by improving this method using simultaneous structural, functional, and metabolic

  20. Vision Trainer Teaches Focusing Techniques at Home

    Science.gov (United States)

    2015-01-01

    Based on work Stanford Research Institute did for Ames Research Center, Joseph Trachtman developed a vision trainer to treat visual focusing problems in the 1980s. In 2014, Trachtman, operating out of Seattle, released a home version of the device called the Zone-Trac. The inventor has found the biofeedback process used by the technology induces an alpha-wave brain state, causing increased hand-eye coordination and reaction times, among other effects

  1. A lumped parameter model of plasma focus

    International Nuclear Information System (INIS)

    Gonzalez, Jose H.; Florido, Pablo C.; Bruzzone, H.; Clausse, Alejandro

    1999-01-01

    A lumped parameter model to estimate neutron emission of a plasma focus (PF) device is developed. The dynamic of the current sheet is calculated using a snowplow model, and the neutron production with the thermal fusion cross section for a deuterium filling gas. The results were contrasted as a function of the filling pressure with experimental measurements of a 3.68 KJ Mather-type PF. (author)

  2. Project Management with IT Security Focus

    OpenAIRE

    Felician Alecu; Paul Pocatilu; Sergiu Capisizu

    2011-01-01

    The paper focus on the main key points related to the IT security project management. The most important lifecycle stages are identified: IT security project proposal definition, project organization, project planning, quality planning, project team organization, IT security project activities management and project closing. The most important success factors for IT security projects are the support of top-management, customer satisfaction, prevention over remediation and continuous progress....

  3. Simulation Of Gas Focused Liquid Jets

    OpenAIRE

    Zahoor, Rizwan

    2018-01-01

    The main aim of dissertation is to develop an experimentally verified computational fluid dynamic (CFD) model of micron-sized liquid jet, produced by an injection molded Gas Dynamic Virtual Nozzle (GDVN). In these nozzles, liquid jets are efficiently orientedly transporting mass and momentum. They are produced by intelligently projecting hydrodynamic focusing effect from a high-speed stream of a co-flowing lower density and lower viscosity gas on a stream of liquid from a feeding capillary. L...

  4. Charmed baryons photoproduced in FOCUS at Fermilab

    CERN Document Server

    Ratti, S P

    2001-01-01

    FOCUS collected over 7 * 10/sup 7/ triggers and more than 10/sup 6/ fully reconstructed charm particles in a photoproduction experiment at Fermilab. The experimental setup is an upgraded version of a multiparticle spectrometer used in the previous experiment E687. Data on charmed meson spectroscopy have been presented by F.L Fabbri in this Section. Here data on photoproduction of charmed baryons are presented.

  5. Architecture and Energy. Towards a broader Focus

    DEFF Research Database (Denmark)

    Lauring, Michael; Marsh, Rob

     Architecture and Energy. Towards a broader focus. By Michael Lauring and Rob Marsh   In typical new Danish dwellings build according to the standards of the Building Regulations 2008 approximately 35% of the primary energy use is related to heat consumption divided into 23% room heating and 12% ...... & Hacker (2008): Bygninger, Energi, Klima. Mod et nyt paradigme.  Statens Byggeforskningsinstitut (Danish Building Research Institute). [2] Marsh, Larsen, Lauring & Christensen (2006): Arkitektur og energi. Statens Byggeforskningsinstitut (Danish Building Research Instititute)....

  6. Focusing magnets for HIF based on racetracks

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N N; Manahan, R R

    2000-09-11

    Heavy Ion Fusion (HIF) is considered a promising path to a practical fusion reactor. A driver for a HIF reactor will require a large number of quadrupole arrays to focus heavy ion beams. A conceptual design, and trade off studies of the quadrupole array based on racetracks are presented. A comparison with a conventional shell magnet is given and advantages and disadvantages are discussed. A more detailed design of a single quadrupole for the High Current experiment (HCX) is presented and discussed.

  7. Results of Final Focus Test Beam

    Energy Technology Data Exchange (ETDEWEB)

    Walz, Dieter R

    2003-06-13

    The beam experiments of Final Focus Test Beam (FFTB) started in September 1993 at SLAC, and have produced a 1.7 {micro}m x 75 nm spot of 46 GeV electron beam. A number of new techniques involving two nanometer spot-size monitors have been developed. Several beam diagnostic/tuning schemes are applied to achieve and maintain the small spot. This experiment opens the way toward the nanometer world for future linear colliders.

  8. Ion Distribution Measurement In Plasma Focus

    International Nuclear Information System (INIS)

    Suryadi; Sunardi; Usada, Widdi; Purwadi, Agus; Zaenuri, Akhmad

    1996-01-01

    Measurement of the Argon ion distribution in plasma focus by using Faraday cup has been done. The intensity of ion beam followed the I Rn rule, n=1,02. In the operation condition of 0,8 mbar and 12,5 kV the current sheath spen 2.2 to 2.4 μsecond in the rundown phase. Cu ion was also been observed in the Faraday cup

  9. The Upgraded Plasma Focus Installation > - The Installation >

    International Nuclear Information System (INIS)

    Krokhin, O.N.; Nikulin, V.Ya.; Babenko, B.A.; Gorbunov, D.N.; Gurei, A.E.; Kalachev, N.V.; Kozlova, T.A.; Malafeev, Yu.S.; Polukhin, S.N.; Sychev, A.A.; Tikhomirov, A.A.; Tsybenko, S.P.; Volobuev, I.V.

    1999-01-01

    The paper presents the upgraded plasma focus installation > - the installation > and some preliminary experimental results. The total energy stored in capacity bank is now 400 kJ, current - 5 MA with the rise time 3.5 μs. The investigation is targeted on the study of near electrode processes and its influence on plasma dynamics in a special operating regime of Filippov type PF - Hard X-ray regime. (author)

  10. Understanding weight stigmatization: a focus group study.

    Science.gov (United States)

    Cossrow, N H; Jeffery, R W; McGuire, M T

    2001-01-01

    The purpose of this research was to investigate, in a nonclinical sample of adults, thoughts on and experiences with weight stigmatization. Focus groups were used to collect information. Participants were recruited through a newspaper advertisement and flyers posted in public places in Minneapolis and St. Paul. During the focus groups, participants were led in a discussion about their thoughts on weight stigmatization and personal experiences of being treated differently or poorly because of their weight. Six gender-specific focus groups consisted of 31 adult volunteers (17 women and 14 men). Perceptions of weight-based stereotypes and weight stigmatization and personal reports of having been treated differently or poorly owing to weight were measured. Participants reported a variety of experiences of being treated differently or poorly because of their weight. These included teasing, harassment, slurs and insults, negative judgments and assumptions, and perceived discrimination. Participants reported that such experiences occurred at home, among friends and strangers, at work, and in health care settings. Women reported a greater number and a greater variety of negative experiences than men. The results indicated that participants experienced weight-based stigmatization in many aspects of their lives. Awareness of these experiences may assist in the development of treatments for overweight individuals.

  11. Safety, training focus of combined organization

    Energy Technology Data Exchange (ETDEWEB)

    Toop, L.

    2006-03-15

    This article presented details of Enform, a company that coordinates safety programs and training for new employees in the oil and gas industry. Enform was created when the Petroleum Industry Training Services merged with the Canadian Petroleum Safety Council. The aim of Enform is to ensure continuous improvements in health and safety within the industry by reducing working injuries and promoting health and safety practices. The companies merged to eliminate duplication of services and allow associates further opportunities for advanced training. In 2005, Enform trained an estimated 155,000 students, and a number of new courses were introduced and updated. A franchise program was extended and a training council was formed to offer direction and guidance to the oil industry. Enform focuses on sharing information among companies, as well as working to harmonize safety regulations across provincial borders. A task force was recently created by the company with a specific focus on drug and alcohol abuse. Other concerns include driver safety and driver interactions with wildlife. Enform is mainly focused on the traditional oil industry, and has had little entry into the oil sands industry. It was concluded that increased activity in the oil and gas industry will remain Enform's biggest challenge in the next few years. Plans for Enform's increased involvement in the offshore oil and gas industry were also discussed. 4 figs.

  12. [Progresses of alpine treeline formation mechanism.

    Science.gov (United States)

    Cong, Yu; He, Hong Shi; Gu, Xiao Nan; Xu, Wen Ru; Liu, Kai; Zong, Sheng Wei; Du, Hai Bo

    2016-09-01

    Alpine treelines represent one of the most distinct vegetation boundaries between canopy closed montane forest and treeless alpine vegetation. This transitional ecotone is highly sensitive to global and regional climate change and is considered as an ideal indicator of such changes. Treeline studies have evolved from morphological description to various hypotheses of treeline formation. Although individual hypothesis may provide reasonable explanation locally, a generalized hypothesis that is applicable on the global scale is still lacking. Temperature is considered the limited factor controlling the distribution of alpine treeline as low temperature restricts biochemical processes of tree growth. However, which particular biochemical processes are affected by low temperature remains unknown. This paper summarized the mechanisms of treeline formation with a focus on how low temperature affects photosynthesis characteristics, nutrient characteristics, non-structural carbohydrate (NSC) and antioxidant system. We also reviewed the key issues and future perspectives in treeline research.

  13. Optimal wave focusing for seismic source imaging

    Science.gov (United States)

    Bazargani, Farhad

    In both global and exploration seismology, studying seismic sources provides geophysicists with invaluable insight into the physics of earthquakes and faulting processes. One way to characterize the seismic source is to directly image it. Time-reversal (TR) focusing provides a simple and robust solution to the source imaging problem. However, for recovering a well- resolved image, TR requires a full-aperture receiver array that surrounds the source and adequately samples the wavefield. This requirement often cannot be realized in practice. In most source imaging experiments, the receiver geometry, due to the limited aperture and sparsity of the stations, does not allow adequate sampling of the source wavefield. Incomplete acquisition and imbalanced illumination of the imaging target limit the resolving power of the TR process. The main focus of this thesis is to offer an alternative approach to source imaging with the goal of mitigating the adverse effects of incomplete acquisition on the TR modeling. To this end, I propose a new method, named Backus-Gilbert (BG) source imaging, to optimally focus the wavefield onto the source position using a given receiver geometry. I first introduce BG as a method for focusing waves in acoustic media at a desired location and time. Then, by exploiting the source-receiver reciprocity of the Green function and the linearity of the problem, I show that BG focusing can be adapted and used as a source-imaging tool. Following this, I generalize the BG theory for elastic waves. Applying BG formalism for source imaging requires a model for the wave propagation properties of the earth and an estimate of the source location. Using numerical tests, I next examine the robustness and sensitivity of the proposed method with respect to errors in the earth model, uncertainty in the source location, and noise in data. The BG method can image extended sources as well as point sources. It can also retrieve the source mechanism. These features of

  14. Restoring formation after leaching process

    International Nuclear Information System (INIS)

    Barrett, R.B.

    1983-01-01

    A method of restoring a formation which had uranium and other mineral values extracted by an alkaline lixiviant comprises introducing a source of phosphate in an amount sufficient to lower the level of soluble uranium compounds below that previously existing in the formation by the formation of insoluble uranium phosphate compounds

  15. Formative Research in Educational Media.

    Science.gov (United States)

    Hodapp, Timothy

    This paper distinguishes between basic research, applied research, and evaluation. Evaluation is broken down into two types: summative and formative. The limitations of formative research are presented, followed by a discussion of the value of the formative researcher participating in the product planning process. The types of data which formative…

  16. Designing for informed group formation

    DEFF Research Database (Denmark)

    Nicolajsen, Hanne Westh; Juel Jacobsen, Alice; Riis, Marianne

    2012-01-01

    A new design ―project preparation‖ preparing for the group formation in problem based project work is proposed and investigated. The main problem is to overcome group formation based on existing relations. The hypothesis is that theme development and group formation are somewhat counterproductive...

  17. Finding focus: a study of the historical development of focus in English

    NARCIS (Netherlands)

    Komen, E.R.

    2013-01-01

    This study reveals how two important focus articulations change over time in written English. Constituent focus, often accompanied by contrast, makes use of the clause-initial position in the oldest stages of English, but as this position comes to be used for the grammatical subject over time, the

  18. Physiological and molecular biochemical mechanisms of bile formation

    Science.gov (United States)

    Reshetnyak, Vasiliy Ivanovich

    2013-01-01

    This review considers the physiological and molecular biochemical mechanisms of bile formation. The composition of bile and structure of a bile canaliculus, biosynthesis and conjugation of bile acids, bile phospholipids, formation of bile micellar structures, and enterohepatic circulation of bile acids are described. In general, the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical membranes. Knowledge of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes, associated with diseases of the liver and biliary tract. PMID:24259965

  19. A new electrophoretic focusing principle: focusing of nonamphoteric weak ionogenic analytes using inverse electromigration dispersion profiles.

    Science.gov (United States)

    Gebauer, Petr; Malá, Zdena; Bocek, Petr

    2010-03-01

    This contribution introduces a new separation principle in CE which offers focusing of weak nonamphoteric ionogenic species and their inherent transport to the detector. The prerequisite condition for application of this principle is the existence of an inverse electromigration dispersion profile, i.e. a profile where pH is decreasing toward the anode or cathode for focusing of anionic or cationic weak analytes, respectively. The theory presented defines the principal conditions under which an analyte is focused on a profile of this type. Since electromigration dispersion profiles are migrating ones, the new principle offers inherent transport of focused analytes into the detection cell. The focusing principle described utilizes a mechanism different from both CZE (where separation is based on the difference in mobilities) and IEF (where separation is based on difference in pI), and hence, offers another separation dimension in CE. The new principle and its theory presented here are supplemented by convincing experiments as their proof.

  20. EDITORIAL: Focus on Dilute Magnetic Semiconductors FOCUS ON DILUTE MAGNETIC SEMICONDUCTORS

    Science.gov (United States)

    Chambers, Scott A.; Gallagher, Bryan

    2008-05-01

    papers, the authors have not carried out the necessary control experiments and materials characterization to convincingly eliminate these possibilities. The former includes the growth of films without the magnetic dopant and the associated demonstration of the absence of ferromagnetism. Magnetic secondary phase formation is particularly problematic because in order to inject enough magnetic dopant to generate appreciable magnetization and spin polarization, one must often exceed the solid solubility of the dopant in the host. If the dopant is itself ferromagnetic in its elemental state, or if unintended magnetic products nucleate, spurious ferromagnetism will occur. Moreover, it is often a major analysis challenge to detect secondary phases when they consist of only a few per cent of the dopant; element specific spectroscopies such as x-ray absorption have been invaluable in this task. Powder diffraction is not sufficiently sensitive for this level of analysis. Against this backdrop, this focus issue of New Journal of Physics now appears. The editors' principal goal in soliciting papers has been to encourage investigators to submit work in which the necessary experiments have been done to allow the material to be adequately characterized. This collection contains a mix of experimental and theoretical papers, and many different types of materials are covered. This focus issue thus constitutes a snapshot in time of a fast-moving and fascinating field of materials physics. Reference [1] Dietl T, Ohno H, Matsukura F, Cibert J and Ferrand D 2000 Science 287 1019 Focus on Dilute Magnetic Semiconductors Contents Lithographically and electrically controlled strain effects on anisotropic magnetoresistance in (Ga,Mn)As E De Ranieri, A W Rushforth, K Výborný, U Rana, E Ahmad, R P Campion, C T Foxon, B L Gallagher, A C Irvine, J Wunderlich and T Jungwirth Structure and magnetism of cobalt-doped ZnO thin films M Ivill, S J Pearton, S Rawal, L Leu, P Sadik, R Das, A F Hebard, M

  1. Implication of formative assessment practices among mathematics teacher

    Science.gov (United States)

    Samah, Mas Norbany binti Abu; Tajudin, Nor'ain binti Mohd

    2017-05-01

    Formative assessment of school-based assessment (SBA) is implemented in schools as a move to improve the National Education Assessment System (NEAS). Formative assessment focuses on assessment for learning. There are various types of formative assessment instruments used by teachers of mathematics, namely the form of observation, questioning protocols, worksheets and quizzes. This study aims to help teachers improve skills in formative assessments during the teaching and learning (t&l) Mathematics. One mathematics teacher had been chosen as the study participants. The collecting data using document analysis, observation and interviews. Data were analyzed narrative and assessments can help teachers implement PBS. Formative assessment is conducted to improve the skills of students in t&l effectively.

  2. Determinants for gallstone formation

    DEFF Research Database (Denmark)

    Shabanzadeh, Daniel Monsted; Sorensen, Lars Tue; Jørgensen, Torben

    2016-01-01

    . Gallstone incidence was assessed through repeated ultrasound examinations. Body mass index (BMI), blood pressure, self-rated health, lifestyle variables, blood lipids, and use of female sex hormones were measured at the baseline examination. Statistical analyses included logistic regression. Based...... re-examination were followed-up completely (mean 11.6 years, N = 2848). The overall cumulative incidence of gallstones was 0.60% per year. Independent positive determinants for incident gallstones were age, female sex, non-high density lipoprotein (non-HDL) cholesterol, and gallbladder polyps...... associations were found for blood pressure, smoking, alcohol consumption, HDL cholesterol, or triglycerides in meta-analyses. Conclusions: Age, female sex, BMI, non-HDL cholesterol, and polyps are independent determinants for gallstone formation. Incident gallstones and the metabolic syndrome share common risk...

  3. Standardizing exchange formats

    International Nuclear Information System (INIS)

    Lemmel, H.D.; Schmidt, J.J.

    1992-01-01

    An international network of co-operating data centres is described who maintain identical data bases which are simultaneously updated by an agreed data exchange procedure. The agreement covers ''data exchange formats'' which are compatible to the centres' internal data storage and retrieval systems which remain different, optimized at each centre to the available computer facilities and to the needs of the data users. Essential condition for the data exchange is an agreement on common procedures for the data exchange is an agreement on common procedures for the data compilation, including critical data analysis and validation. The systems described (''EXFOR'', ''ENDF'', ''CINDA'') are used for ''nuclear reaction data'', but the principles used for data compilation and exchange should be valid also for other data types. (author). 24 refs, 4 figs

  4. Recipes for planet formation

    Science.gov (United States)

    Meyer, Michael R.

    2009-11-01

    Anyone who has ever used baking soda instead of baking powder when trying to make a cake knows a simple truth: ingredients matter. The same is true for planet formation. Planets are made from the materials that coalesce in a rotating disk around young stars - essentially the "leftovers" from when the stars themselves formed through the gravitational collapse of rotating clouds of gas and dust. The planet-making disk should therefore initially have the same gas-to-dust ratio as the interstellar medium: about 100 to 1, by mass. Similarly, it seems logical that the elemental composition of the disk should match that of the star, reflecting the initial conditions at that particular spot in the galaxy.

  5. Formation of Service Ecosystems

    DEFF Research Database (Denmark)

    Jonas, Julia M.; Sörhammar, David; Satzger, Gerhard

    – i.e. the “birth phase” (Moore, 2009) of a service ecosystem. This paper, therefore, aims to explore how the somewhat “magic” processes of service ecosystem formation that are being taken for granted actually occur. Methodology/Approach: Building on a review of core elements in the definitions...... for Harvard students) or value proposition (share messages, photos, videos, etc. with friends). Processes of configuring actors, resources, and value propositions are influenced by the structural embeddedness of the service ecosystem (e.g., regional infrastructure, existing networks of actors, or resource...... availability) as well as guided by the actors’ own and shared institutions (e.g., rules, norms,and beliefs).We contextualize each starting point with illustrative cases and analyze the service ecosystem configuration process: “Axoon/Trumpf” (initiated by resources), “JOSEPHS – the service manufactory...

  6. Symbol Formation Reconsidered

    DEFF Research Database (Denmark)

    Wagoner, Brady

    2013-01-01

    them vis-à-vis other research at Clark and in American psychology more generally. The second two articles analyse Werner and Kaplan’s notions of ‘distancing’ and ‘physiognomic metaphor’, showing their roots in naturphilosophie and comparing them with contemporary theories. The last four articles apply......Werner and Kaplan’s Symbol formation was published 50 years ago but its insights have yet to be adequately explored by psychology and other social sciences. This special issue aims to revisit this seminal work in search of concepts to work on key issues facing us today. This introductory article...... begins with a brief outline and contextualization of the book as well as of the articles that this special issue comprises. The first two articles were written by contributors who were part of the Werner era at Clark University. They explore the key concepts of the organismic and development, and situate...

  7. Doping and cluster formation in diamond

    KAUST Repository

    Schwingenschlö gl, Udo; Chroneos, Alexander; Grimes, R. W.; Schuster, Cosima

    2011-01-01

    Introducing a cluster formation model, we provide a rational fundamental viewpoint for the difficulty to achieve n-type dopeddiamond. We argue that codoping is the way forward to form appropriately doped shallow regions in diamond and other forms of carbon such as graphene. The electronegativities of the codopants are an important design criterion for the donor atom to efficiently donate its electron. We propose that the nearest neighbour codopants should be of a considerably higher electronegativity compared to the donor atom. Codoping strategies should focus on phosphorous for which there are a number of appropriate codopants.

  8. Doping and cluster formation in diamond

    KAUST Repository

    Schwingenschlögl, Udo

    2011-09-09

    Introducing a cluster formation model, we provide a rational fundamental viewpoint for the difficulty to achieve n-type dopeddiamond. We argue that codoping is the way forward to form appropriately doped shallow regions in diamond and other forms of carbon such as graphene. The electronegativities of the codopants are an important design criterion for the donor atom to efficiently donate its electron. We propose that the nearest neighbour codopants should be of a considerably higher electronegativity compared to the donor atom. Codoping strategies should focus on phosphorous for which there are a number of appropriate codopants.

  9. Tanks focus area. Annual report 1997

    International Nuclear Information System (INIS)

    Frey, J.

    1997-01-01

    The U.S. Department of Energy Office of Environmental Management is tasked with a major remediation project to treat and dispose of radioactive waste in hundreds of underground storage tanks. These tanks contain about 90,000,000 gallons of high-level and transuranic wastes. We have 68 known or assumed leaking tanks, that have allowed waste to migrate into the soil surrounding the tank. In some cases, the tank contents have reacted to form flammable gases, introducing additional safety risks. These tanks must be maintained in the safest possible condition until their eventual remediation to reduce the risk of waste migration and exposure to workers, the public, and the environment. Science and technology development for safer, more efficient, and cost-effective waste treatment methods will speed up progress toward the final remediation of these tanks. The DOE Office of Environmental Management established the Tanks Focus Area to serve as the DOE-EM's technology development program for radioactive waste tank remediation in partnership with the Offices of Waste Management and Environmental Restoration. The Tanks Focus Area is responsible for leading, coordinating, and facilitating science and technology development to support remediation at DOE's four major tank sites: the Hanford Site in Washington State, Idaho National Engineering and Environmental Laboratory in Idaho, Oak Ridge Reservation in Tennessee, and the Savannah River Site in South Carolina. The technical scope covers the major functions that comprise a complete tank remediation system: waste retrieval, waste pretreatment, waste immobilization, tank closure, and characterization of both the waste and tank. Safety is integrated across all the functions and is a key component of the Tanks Focus Area program

  10. The combination of electrospray and flow focusing

    Science.gov (United States)

    Gañán-Calvo, Alfonso M.; López-Herrera, José M.; Riesco-Chueca, Pascual

    2006-11-01

    An ultra-fine liquid atomization procedure combining the advantages of electrospray and flow focusing is presented. Both techniques are known to produce strikingly small and steady liquid micro-jets issuing from menisci held by capillary forces. Such menisci take the form of a cusp-like drop attached to the feeding tube (flow focusing: FF) or a Taylor cone (electrospray: ES). The issuing micro-jets are forced or ‘sucked’ from the parent meniscus either by pressure or electrohydrodynamic forces. Subsequent capillary breakup of the jet leads to fine sprays of remarkable quality. Here we describe the joint effect of pressurization and electrification in a flow focusing device, and the subsequent coupling of both ES and FF phenomena. For any given liquid and flow rate, the combined procedure gives rise to significantly smaller droplet sizes than observed in any of the source techniques. The co-flowing gas stream removes space charges; in addition, the perforated plate facing the feed tube provides an electric barrier, shielding the jet-meniscus or ‘production’ area from the spray or ‘product’ area. As a result, space charges and electrified droplets are removed from the production area, thus avoiding the ambient electric saturation which becomes a limiting factor in ES-spraying: a significantly enhanced spraying stability ensues, with a much wider operation range than FF or ES. Other unexpected outcomes from the combination are also shown. A theoretical model is developed to predict the emitted droplet size: a first integral of the momentum equation yielding a generalized Bernoulli equation, and an explicit approximation for the jet diameter and droplet size, accurate within a broad parametrical band.

  11. Electron density measurements on the plasma focus

    International Nuclear Information System (INIS)

    Rueckle, B.

    1976-01-01

    The paper presents a determination of the maximum electron density in a plasma focus, produced with the NESSI experimental setup, by the method of laser beam deflection. For each discharge a time-resolved measurement was performed at four different places. Neutron efficiency as well as the time of the initial X-ray emission was registrated. The principle and the economic aspects of the beam deflection method are presented in detail. The experimental findings and the resulting knowledge of the neutron efficiency are discussed. (GG) [de

  12. Focusing experiments with light ion diodes

    International Nuclear Information System (INIS)

    Johnson, D.L.

    1978-01-01

    A review of recent experimental and theoretical work at Sandia Laboratories on magnetically insulated single stage ion diodes for inertial confinement fusion experiments is presented. The production, focusing, and numerical simulation of a 0.5 TW annular proton beam using the Proto I dual transmission line generator is described. The modular magnetically insulated ion diode for the Hydra generator is also described along with recent experimental results. A brief description of how an array of modular diodes similar to the Hydra magnetically insulated diode could be used on the EBFA I generator for breakeven fusion experiments is presented

  13. Focusing over Optical Fiber Using Time Reversal

    DEFF Research Database (Denmark)

    Piels, Molly; Porto da Silva, Edson; Estaran Tolosa, Jose Manuel

    2015-01-01

    A time-reversal array in multimode fiber is proposed for lossless remotely controlled switching using passive optical splitters. The signal to be transmitted is digitally pre-distorted so that it is routed through the physical layer in order to arrive at only one receiver in an array. System...... performance in the presence of additive white gaussian noise, modal group delay, and timing error is investigated numerically for single-mode and 10-mode fiber. Focusing using a two-transmitter array and 44 km of single- mode fiber is demonstrated experimentally for 3 GBd QPSK signals with a bit error rate...

  14. Focus point from direct gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Sibo [Chongqing University, Department of Physics, Chongqing (China)

    2015-01-01

    This paper is devoted to the reconciliation of the tension between the theoretic expectation from naturalness and the present LHC limits on the superpartner mass bounds. We argue that in supersymmetry models of direct gauge mediation the focusing phenomenon appears, which dramatically reduces the fine tuning associated to the 126 GeV Higgs boson. This type of model is highly predictive as regards the mass spectrum, with a multi-TeV third generation, the A{sub t} term of order 1 TeV, gluino mass above LHC mass bound, and the light neutralinos and charginos below 1 TeV. (orig.)

  15. Triplet Focusing for Recirculating Linear Muon Accelerators

    CERN Document Server

    Keil, Eberhard

    2001-01-01

    Focusing by symmetrical triplets is studied for the linear accelerator lattices in recirculating muon accelerators with several passes where the ratio of final to initial muon energy is about four. Triplet and FODO lattices are compared. At similar acceptance, triplet lattices have straight sections for the RF cavities that are about twice as long as in FODO lat-tices. For the same energy gain, the total lengths of the linear accelerators with triplet lattices are about the same as of those with FODO lattices.

  16. Orbiter radiator panel solar focusing test

    Science.gov (United States)

    Howell, H. R.; Rankin, J. G.

    1983-01-01

    Test data are presented which define the area around the Orbiter radiator panels for which the solar reflections are concentrated to one-sun or more. The concave shape of the panels and their specular silver/Teflon coating causes focusing of the reflected solar energy which could have adverse heating effects on equipment or astronaut extravehicular activity (EVA) in the vicinity of the radiator panels. A room ambient test method was utilized with a one-tenth scale model of the radiator panels.

  17. Mixed Waste Focus Area program management plan

    International Nuclear Information System (INIS)

    Beitel, G.A.

    1996-10-01

    This plan describes the program management principles and functions to be implemented in the Mixed Waste Focus Area (MWFA). The mission of the MWFA is to provide acceptable technologies that enable implementation of mixed waste treatment systems developed in partnership with end-users, stakeholders, tribal governments and regulators. The MWFA will develop, demonstrate and deliver implementable technologies for treatment of mixed waste within the DOE Complex. Treatment refers to all post waste-generation activities including sampling and analysis, characterization, storage, processing, packaging, transportation and disposal

  18. Centroid motion in periodically focused beams

    International Nuclear Information System (INIS)

    Moraes, J.S.; Pakter, R.; Rizzato, F.B.

    2005-01-01

    The role of the centroid dynamics in the transport of periodically focused particle beams is investigated. A Kapchinskij-Vladimirskij equilibrium distribution for an off-axis beam is derived. It is shown that centroid and envelope dynamics are uncoupled and that unstable regions for the centroid dynamics overlap with previously stable regions for the envelope dynamics alone. Multiparticle simulations validate the findings. The effects of a conducting pipe encapsulating the beam are also investigated. It is shown that the charge induced at the pipe may generate chaotic orbits which can be detrimental to the adequate functioning of the transport mechanism

  19. Arabinogalactan proteins: focus on carbohydrate active enzymes

    Directory of Open Access Journals (Sweden)

    Eva eKnoch

    2014-06-01

    Full Text Available Arabinogalactan proteins (AGPs are a highly diverse class of cell surface proteoglycans that are commonly found in most plant species. AGPs play important roles in many cellular processes during plant development, such as reproduction, cell proliferation, pattern formation and growth, and in plant-microbe interaction. However, little is known about the molecular mechanisms of their function. Numerous studies using monoclonal antibodies that recognize different AGP glycan epitopes have shown the appearance of a slightly altered AGP glycan in a specific stage of development in plant cells. Therefore, it is anticipated that the biosynthesis and degradation of AGP glycan is tightly regulated during development. Until recently, however, little was known about the enzymes involved in the metabolism of AGP glycans. In this review, we summarize recent discoveries of carbohydrate active enzymes (CAZy; http://www.cazy.org/ involved in the biosynthesis and degradation of AGP glycans, and we discuss the biological role of these enzymes in plant development.

  20. BIOENERGIA - Focus on wood in bioenergy research

    Energy Technology Data Exchange (ETDEWEB)

    Asplund, D. [Jyvaeskylae Science Park, Jyvaeskylae (Finland)

    1996-12-31

    The most important area of research on wood fuel production is the development of various methods, machines and systems connected to this area, in order to produce economically competitive fuels. The integrated harvesting methods, which supply both raw material to wood products industry and wood fuel for energy production, have been chosen the main research area because they seem to be most promising. The growing amount of small-sized trees ant the need of their first thinnings have created a demand for new harvesting methods. At the moment the economical aspects restrict the harvesting of the first thinning trees either for industrial use or energy production. Research on peat production focuses on the complete use of a bog and on the development of peat production methods and machines. Development work in this area aims at decreasing production costs and also at reducing the drainage water and other elements in environmental load around the peat production sites. The use of bioenergy research will be focused on the small-scale (<20 MW{sub th},) applications. In the long term, the increase of bioenergy in heating of small houses and farms and buildings, as well as in the production of heat and power has been estimated. Research into the conversion of biomass is concentrated on the production of biomass-based liquid fuels