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Sample records for hrak indrek ots

  1. Indrek Kasela, Hamlet ärimaailmas / Indrek Kasela ; intervjueerinud Priit Pullerits ; kommenteerinud Maarja Neilvelt

    Index Scriptorium Estoniae

    Kasela, Indrek, 1971-

    2010-01-01

    Ettevõtja, kino Sõprus taasavaja ning Premia börsile viija Indrek Kasela oma tegevusest fondihaldurina, New Yorgi ülikoolis saadud kogemustest, Eesti ühiskonnakorralduses vaja minevatest muutustest

  2. Indrek Treufeldti kaks elu / intervjueerinud Tiia Nightingale

    Index Scriptorium Estoniae

    Treufeldt, Indrek, 1969-

    2014-01-01

    Intervjuu telesaate "Kahekõne" saatejuhi ning doktorikraadiga teadlase ja Balti Filmi- ja Meediakooli õppejõu Indrek Treufeldtiga telesaate ja teaduse tegemisest, Eesti ja maailma probleemidest, eesti keele tulevikust

  3. Malbe ja sihikindel Indrek Rahumaa / Väinu Rozental

    Index Scriptorium Estoniae

    Rozental, Väinu, 1957-

    2007-01-01

    Indrek Rahumaa suurosalusega investeerimisfond on viimase pooleteise aastaga investeerinud agressiivsesse laienemisse üle kolme miljardi krooni. Vt. samas: CV; Alta Capital tänavu hoogsalt laienenud. Kommenteerivad Eimar Rahumaa ja Jaak Raid

  4. Pesukuningas hakkab Kalevit valitsema / Indrek Rahumaa ; interv. Andrus Karnau

    Index Scriptorium Estoniae

    Rahumaa, Indrek, 1972-

    2007-01-01

    Alta Capital Partnersi enamusosanik räägib Kalevi ja Tere ostmisest, ettevõtete edasistest perspektiividest ja soovist ehitada Läänemere äärde tugev toiduainete tootmise kontsern. Lisad: Indrek Rahumaa CV ; Alta Capital Partners omanikud ; Alta Capital Partnersi investeeringud

  5. Paariselamu Luccas = Duplex House in Lucca / Indrek Allmann

    Index Scriptorium Estoniae

    Allmann, Indrek, 1972-

    2001-01-01

    Projekteerija: Arhitektuuribüroo Kolde Grupp. Arhitekt Indrek Allmann, konstruktorid Andres Läänesaar, Aldur Parts, Valdo Jaanisoo, Mait Mets. Hoone asub panga ülemise tasandi kõrgusel õhus, pangapealsega on ühendatud terrassi abil, ligipääs alumisel tasandil. Projekt 1999, valmis 2001. 5 ill.: põhiplaan, vaated

  6. EMT omanik läks Rootsis üle kuutasule / Indrek Kald

    Index Scriptorium Estoniae

    Kald, Indrek, 1974-

    2004-01-01

    Eesti Mobiiltelefoni omanikfirma Telia loobus Rootsi mobiilsidevõrgus minutipõhise tasu arvestamisest, asendades selle fikseeritud kuutasuga. Taolise lahenduse võimalikku kasutamist Eestis kommenteerib Indrek Randveer EMT-st

  7. Judokas Indrek Pertelson rajab veel sel aastal kaks spordikeskust / Merike Teder

    Index Scriptorium Estoniae

    Teder, Merike

    2005-01-01

    Tippspordiga lõpparve teinud judoka Indrek Pertelson avab veel sel aastal Tallinnas kaks perespordikeskust, kus peale idamaiste võitlusviiside harrastamise saab ka tervist kontrollida ja jõudu taastada

  8. OT-Combiners Via Secure Computation

    DEFF Research Database (Denmark)

    Harnik, Danny; Ishai, Yuval; Kushilevitz, Eyal

    2008-01-01

    of faulty candidates (t = Ω(n)). Previous OT-combiners required either ω(n) or poly(k) calls to the n candidates, where k is a security parameter, and produced only a single secure OT. We demonstrate the usefulness of the latter result by presenting several applications that are of independent interest......An OT-combiner implements a secure oblivious transfer (OT) protocol using oracle access to n OT-candidates of which at most t may be faulty. We introduce a new general approach for combining OTs by making a simple and modular use of protocols for secure computation. Specifically, we obtain an OT......, strengthen the security, and improve the efficiency of previous OT-combiners. In particular, we obtain the first constant-rate OT-combiners in which the number of secure OTs being produced is a constant fraction of the total number of calls to the OT-candidates, while still tolerating a constant fraction...

  9. Indrek Saar kehastub Pilistveres Rasputiniks / Aarne Mäe

    Index Scriptorium Estoniae

    Mäe, Aarne, 1967-

    2008-01-01

    7. aug. esietendub Pilistvere vanas rehehoones Ain Saviaugu kirjutatud ja lavastatud suvetükk "Rasputin". Suvelavastuse tõi välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar. Lisaks lühike intervjuu lavastajaga "Lavastaja Ain Saviauk : "Ajalugu on karm" ja fakte Rasputinist - "Grigori Jefimovitsh Rasputin-Novõhh"

  10. Indrek Rahumaa küsis veel ajapikendust / Kertu Ruus, Silvia Kruusmaa

    Index Scriptorium Estoniae

    Ruus, Kertu, 1977-

    2008-01-01

    Indrek Rahumaa juhitav Alta Capital tasub Oliver Kruudale Kalevi tütarfirmade eest 660 miljonit krooni hiljemalt 30. maiks. Vt. samas: Rahasaamise viivitus lükkas Kalevi laenurallile. Kommenteerivad Sander Danil ja Kristjan Lepik

  11. Täna 20 aastat tagasi : jaanuar 1988 / Indrek Toome ; interv. Helle Raidla

    Index Scriptorium Estoniae

    Toome, Indrek

    2008-01-01

    Uus rubriik, milles meenutatakse kuust kuusse Eesti iseseisvumise taastamise aja olulisi sündmusi. Vestlus Indrek Toomega, kes nimetati 1988. aasta jaanuaris Eesti Kommunistliku Partei Keskkomitee uueks ideoloogiasekretäriks

  12. Ettepanek seadusandjale : kriminaliseerida näiline ehk varimaksustamine / Indrek Mandre

    Index Scriptorium Estoniae

    Mandre, Indrek, 1964-

    2005-01-01

    Maksumaksjate sisendkäibemaksu mahaarvamisest. Lisatud: Kukk, Rein. Süütuse presumptsioon versus kriminaalmenetluse libaeesmärgid?, lk. 7 ; Mandre, Indrek. Varimetsandust soodustab ka riik, lk. 6. Vt. ka: http://www.maksumaksjad.ee/modules/smartsection/item.php?itemid=32 ; http://www.maksumaksjad.ee/modules/smartsection/item.php?itemid=30

  13. Rasputin aitas Putini mõtlemisse süveneda / Indrek Saar ; interv. Illar Mõttus

    Index Scriptorium Estoniae

    Saar, Indrek, 1973-

    2008-01-01

    Näitleja ja riigikogulane Indrek Saar oma rollist suvelavastuses "Rasputin". Ta annab hinnangu Gruusia sündmustele, osalemisest erakonna esindajana nn. krokodillide komisjonis, mis arutas riigieelarvet

  14. Peaprokurör: kaevake kartellide peale! / Kadri Paas ; kommenteerinud Norman Aas ; Indrek, Kaju

    Index Scriptorium Estoniae

    Paas, Kadri, 1982-

    2009-01-01

    Seaduseelnõust, mille kohaselt salajasest kartellileppest esimesena võimudele teatanud ettevõte pääseb vastutasuks karistusest. Kommenteerivad peaprokurör Norman Aas ning Neste Eesti peadirektor Indrek Kaju

  15. Millest on tehtud arhitektuur? = What is architecture made of? / Indrek Rünkla

    Index Scriptorium Estoniae

    Rünkla, Indrek, 1971-

    2009-01-01

    Arhitekt Indrek Rünkla ettekujutus sellest, mida arhitekt teeb ja tegema peaks, ning ühiskonna vastav kujutus ei kattu. Ta püüab kirjeldada seda osa arhitektuurist, mis ühiskonna arhitektuuripildist välja tahab jääda

  16. Eesti arhitektid Riia linna projekteerimas / Indrek Allmamm, Joel Kopli ; intervjueerinud Margit Mutso

    Index Scriptorium Estoniae

    Allmann, Indrek, 1972-

    2010-01-01

    Eesti arhitektid Indrek Allmann ja Joel Kopli (AB Pluss) võitsid Lätis rahvusvahelise arhitektuurivõistluse, mille eesmärgiks oli leida parim arhitektuurne lahendus hotelliketti Marriott International kuuluvale hotellihoonele Riia vanalinnas. Intervjuu võitjatega sel teemal. Läti arhitektuurist. Riia arhitektuurinõukogust

  17. Fotonäitus koduta loomade heaks / Indrek Galetin, Kerttu Rakke, Angela Aak ... [jt.

    Index Scriptorium Estoniae

    Galetin, Indrek

    2009-01-01

    Rotermani kvartalis 22.05.2009 avatud Indrek Galetini fotonäitus "Amour - Lemmikloomade eri". Kodutute loomade abistamiseks 20.07.2009 oksjonil müüdavate piltide valmimist kommenteerivad fotograaf ja modellid Kerttu Rakke, Angela Aak ja Max Kaur

  18. Meistri kutsumine / Taavi Talve, Indrek Köster ; intervjueerinud Elena Šmakova

    Index Scriptorium Estoniae

    Talve, Taavi

    2009-01-01

    Loomingulise ühenduse Johnson ja Johnson - Taavi Talve, Indrek Köster - näitus "Meistri kutsumine" Hobusepea Galeriis 27. aprillini. Autorid 2006. aastal alustatud Paldiski linnaruumi ja selle elanikke kaasavast projektist, mille lõppeesmärk on luua Paldiskisse Amandus Adamsoni skulptuur. Linnaelanike lemmikuks osutus teos "Laeva viimne ohe", mille savist suurenduse modelleerib Mare Mikof

  19. Puhkus moodsas kalurikülas / Karen Jagodin ; kommenteerinud Indrek Mikk, Raivo Kotov

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    GoSpa residentsid Kuressaares. Arhitektid: Indrek Mikk, Raivo Kotov (KOKO Arhitektid). Sisearhitekt: Kätlin Ölluk. Projekt: 2007, valmis: 2009. Suvitajatele mõeldud viiest kahekorruselisest hoonest koosnev ansambel on liigendatud mahtude ja lehisepuidust-betoonist fassaadidega. Terrassid ja rõdud avanevad peamiselt suunaga merele. Kortereid saab endale osta või üürida

  20. Letni sezon : ot avangardista do "Sjurrealistov" / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2006-01-01

    Suvelavastustest: Andrus Kivirähk "Sürrealistid" Viinistus (lavastaja Hendrik Toompere jun), Mart Kivastik "Kits viiuli ja õngega" Viinistus (lavastaja Raimo Pass), Alfred Jarry "Kuningas Ubu" Teater NO99 Haapsalu Kiltsi lennuvälja angaarides (lavastajad Ene-Liis Semper ja Tiit Ojasoo), Jaan Tätte "Kaev" Tallinna Linnateatri siseõues (lavastaja Indrek Sammul)

  1. 75 FR 51169 - OTS Minority Depository Institutions Advisory Committee

    Science.gov (United States)

    2010-08-18

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [Docket ID: OTS-2010-0026] OTS Minority... (OTS). ACTION: Notice. SUMMARY: The Charter for the OTS Minority Depository Institutions Advisory... of the Treasury to announce the renewal of the OTS Minority Depository Institutions Advisory...

  2. Euroopa päevik aitab tunde läbi viia / Epp Adler, Indrek Riigor

    Index Scriptorium Estoniae

    Adler, Epp

    2008-01-01

    Jaanuari lõpuni saavad kõik Eesti koolid tellida tasuta Euroopa päevikut, kus lisaks kalendrile on 96 lehekülge tekste tarbimise, ühiskonna ja Euroopa teemadel. Tallinna Nõmme Gümnaasiumi ajaloo, ühiskonnaõpetuse ja filosoofia õpetaja Indrek Riigor on päevikut kolm aastat tundides kasutanud

  3. Arhitektuuri tegemise ja tajumise mõtted = Thoughts about creating and perceiving architecture / Siiri Vallner, Indrek Peil ; intervjueerinud Triin Ojari

    Index Scriptorium Estoniae

    Vallner, Siiri, 1972-

    2009-01-01

    Arhitektid Siiri Vallner ja Indrek Peil sellest, mis on arhitektuuris ja oma loomingus oluline, teistelt erialadelt laenamisest, arhitektuuri suhtest kohaga, arhitekti rollist kaasaja ehitusruumis, arhitektuuri tulevikust

  4. Elamu Silgu tänaval Tallinnas = Dwelling on Silgu Street in Tallinn / Ülar Mark, Indrek Tiigi

    Index Scriptorium Estoniae

    Mark, Ülar

    2003-01-01

    Klaasmaja projekteerija: Arhitektuuribüroo Urban Mark. Arhitektid Ülar Mark ja Indrek Tiigi. Konstruktor: Inseneribüroo Peipman OÜ. Sisekujundaja Raina Lillepõld (OÜ Boxes). Projekt 2002, valmis 2004. 4 välis- ja 3 sisevaadet, põhiplaan

  5. Director läks ja küsis / Indrek Randveer, Evelyn Karming, Priit Palk ... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    EMT teenindus- ja müügidirektor Indrek Randveer, Estraveli müügidirektor Evelyn Karming, ABC King/Nero/SHU/Suurtüki turundusjuht Anne-Liis Ostov, kohvik-restoran Crepp juhataja Priit Palk ja Sokos Hotel Viru kommunikatsioonijuht Peep Ehasalu vastavad küsimustele, mis puudutavad nende kogemusi keerukate ja absurdsete kliendikaebuste kohta

  6. Rahumaa ja Raid ehitavad Balti riikide suurimat tööstuskontserni / Indrek Rahumaa, Jaak Raid ; interv. Mikk Salu

    Index Scriptorium Estoniae

    Rahumaa, Indrek, 1972-

    2007-01-01

    Kalevi kompvekivabriku ja Tere piimatööstuse uued omanikud Indrek Rahumaa ja Jaak Raid vastavad küsimustele, mis puudutavad nende edasisi äri- ja investeeringuplaane. Vt. samas: Alta Capital Partners S.C.A.

  7. A categorization of customer concerns for an OT front-end of innovation process in an IT/OT convergence context

    OpenAIRE

    Bonnetto , Emilie; YANNOU , Bernard; Bertoluci , Gwenola; Boly , Vincent; Alvarez , Jorge

    2016-01-01

    International audience; Operational Technologies (OT) are designed to monitor and control plants. OT are increasingly mixed with Information Technologies (IT) in global solutions. A conventional customer inquiry is no more sufficient to get enough data about Customer Concerns (CC). Indeed, an IT OT solution is the nervous system of a company; it intertwines people processes and functions. For specification step, one must now capture negative perceptions in the interrelationships with other ac...

  8. Fabrication of PEDOT-OTS-patterned ITO substrates

    NARCIS (Netherlands)

    Herzer, N.; Wienk, M.M.; Schmit, P.; Spoelstra, A.B.; Hendriks, C.E.; Oosterhout, S.D.; Höppener, S.; Schubert, U.S.

    2010-01-01

    The fabrication of a poly(3,4-ethylenedioxythiophene) (PEDOT) pattern is demonstrated. As template, an n-octadecyltrichlorosilane (OTS) monolayer self-assembled on indium tin oxide (ITO) was structured by UV–ozone photolithography, resulting in an ITO–OTS patterned surface. The conducting properties

  9. Maailma arhitektuurifestival = World Architecture Festival / Ingrid Ruudi ; kommenteerinud Maarja Kask, Karli Luik, Ralf Lõoke, Indrek Allmann, Martin Aunin

    Index Scriptorium Estoniae

    Ruudi, Ingrid, 1978-

    2011-01-01

    Barcelonas 2.-4. nov. 2011 toimunud 4. Maailma arhitektuurifestivalist (WAF). Muljeid jagavad II vooru pääsenud eesti arhitektid Maarja Kask, Karli Luik ja Ralf Lõoke AB-st Salto (Põhuteater, Sõmeru keskus), Martin Aunin (Must maja Nõmmel), Indrek Allmann AB-st Pluss (poolautonoomne saun). Üldvõitja - Media-ICT Barcelonas (Cloud 9 / Enric Ruiz-Geli)

  10. Kui seda mammit seal jalus ei oleks... / Indrek Pajo, Heiti Riisberg, Jaana Liigand... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele, mida peaks noor keskjuht juhtimise osas tegema kui tunneb pärast paarikuist töötamist üha rohkem, et mõned tema alluvad, kes on temast oluliselt vanemad, töötavad talle vastu, vastavad endine Cleaner Ehitus vanemobjektijuht Indrek Pajo, Trigon Kapital pensioni- ja aktsiafondide eest hoolitsev Heiti Riisberg, konsultatsioonifirma Arikano omanik ja juht Jaana Liigand, Pharmadule OÜ personali- ja büroojuht Helen Neeve, Saku Õlletehase brändide Rock ja Carlsberg juht Karin Golubev ning Kaamos Kinnisvara juht Priit Uustulnd

  11. The potential for oxytocin (OT) to prevent breast cancer: a hypothesis.

    Science.gov (United States)

    Murrell, T G

    1995-08-01

    This hypothesis proposes that carcinogens in the breast are generated by the action of superoxide free radicals released when acinal gland distension, under the influence of unopposed prolactin, causes microvessel ischaemia. Inadequate nipple care in the at-risk years leads to ductal obstruction preventing the elimination of carcinogens from the breast. The regular production of oxytocin (OT) from nipple stimulation would cause contraction of the myoepithelial cells, relieving acinal gland distension and aiding the active elimination of carcinogenic fluid from the breast. Mechanical breast pump stimulation causes an increase in plasma OT levels in the luteal but not in the follicular phase of the menstrual cycle. OT production upon nipple stimulation in the luteal phase of premenopausal, non-lactating women may be protective against the high rates of mitotic breast cell division noted at this time via the potential to block the effect of oestrogen. The epidemiology of breast cancer suggests that lengthy lactation time is beneficial. Sexual activity in nulliparous women also protects and OT levels have been shown to rise with orgasm in women and in men. OT systems in the brain are intricately linked to oestrogen and progesterone levels, and it is possible that these hormones may modify the OT secretory response both centrally and through an effect on the sensitivity of the breast. OT production with nipple care and in sex and lactation, and the reduction in cycling ovarian hormones that occurs with pregnancy, may all be important preventative factors in the development of breast cancer both pre- and post-menopausally.

  12. 12 CFR 563b.115 - How will OTS review my business plan?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false How will OTS review my business plan? 563b.115... business plan? (a) OTS will review your business plan to determine that it demonstrates a safe and sound... will be determinative. OTS will review every case on its merits. (b) You must file your business plan...

  13. 12 CFR 500.10 - The OTS or The Office.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false The OTS or The Office. 500.10 Section 500.10 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY AGENCY ORGANIZATION AND FUNCTIONS General Organization § 500.10 The OTS or The Office. The Office of Thrift Supervision (referred to as “OTS” or “Office”) is an office of the...

  14. Superhump Period of MASTER OT

    Science.gov (United States)

    Garnavich, Peter; McClelland, Colin

    2013-02-01

    We observed the optical transient MASTER OT J065608.28+744455.2 (ATEL #4783) with the Vatican Advanced Technology Telescope (VATT) and VATT4K CCD camera. V-band imaging began at 2013 Feb. 5.15 (UT) and continued for 3.3 hours with a time resolution of 22 seconds.

  15. Eestlastest tippjuhid kerge südamega võõrsile leiba teenima ei lähe / Mait Raava, Indrek Neivelt, Maive Rute ; interv. Tuuliki Kasonen-Lins

    Index Scriptorium Estoniae

    Raava, Mait

    2006-01-01

    Pro Konsultatsioonide juhtimiskonsultant Mait Raava, Bank Saint Petersburgi nõukogu esimees Indrek Neivelt, Euroopa Komisjoni innovatsiooni ja väikeettevõtluse üksuse direktor Maive Rute vastavad küsimustele, mis puudutavad Eesti juhtide mainet ning töötamist välisriikides

  16. 12 CFR 563.146 - Will the OTS permit my capital distribution?

    Science.gov (United States)

    2010-01-01

    ... under 12 U.S.C. 1831o(d)(1)(B). (b) Your proposed capital distribution raises safety or soundness... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Will the OTS permit my capital distribution... SAVINGS ASSOCIATIONS-OPERATIONS Capital Distributions § 563.146 Will the OTS permit my capital...

  17. 12 CFR 502.55 - Where can I find OTS's fee schedule?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Where can I find OTS's fee schedule? 502.55 Section 502.55 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY ASSESSMENTS AND... fees in a Thrift Bulletin. OTS will publish these fees at least 30 days before they are effective. ...

  18. Optimization of OT-MACH Filter Generation for Target Recognition

    Science.gov (United States)

    Johnson, Oliver C.; Edens, Weston; Lu, Thomas T.; Chao, Tien-Hsin

    2009-01-01

    An automatic Optimum Trade-off Maximum Average Correlation Height (OT-MACH) filter generator for use in a gray-scale optical correlator (GOC) has been developed for improved target detection at JPL. While the OT-MACH filter has been shown to be an optimal filter for target detection, actually solving for the optimum is too computationally intensive for multiple targets. Instead, an adaptive step gradient descent method was tested to iteratively optimize the three OT-MACH parameters, alpha, beta, and gamma. The feedback for the gradient descent method was a composite of the performance measures, correlation peak height and peak to side lobe ratio. The automated method generated and tested multiple filters in order to approach the optimal filter quicker and more reliably than the current manual method. Initial usage and testing has shown preliminary success at finding an approximation of the optimal filter, in terms of alpha, beta, gamma values. This corresponded to a substantial improvement in detection performance where the true positive rate increased for the same average false positives per image.

  19. Performance of non-ideal OT-MRC with co-channel interference

    KAUST Repository

    Radaydeh, Redha Mahmoud Mesleh

    2010-12-01

    This paper studies the effect of non-ideal estimation of channel state information (CSI) on the performance of output-threshold maximal-ratio combining (OT-MRC) diversity scheme in the presence of co-channel interference as well as white noise. The channel fading envelopes are assumed to follow slowly varying flat Rayleigh model. New closed-form expressions for the combined signal-to-interference-plus-noise ratio (SINR) distribution and outage probability performance are presented. Performance comparisons between the conventional MRC and OT-MRC for the system model described above are provided. © 2010 IEEE.

  20. PREDICTING PROGNOSTIC VALUE OF OCULAR TRAUMA SCORE (OTS IN AN OPEN GLOBE INJURY IN TERTIARY EYE CARE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Rahul

    2015-10-01

    Full Text Available AIM : To evaluate the prognostic value of OTS in open globe injuries. MATERIAL METHOD : Retrospective analysis of 77 eyes with open globe injuries was done from 01/07/2013 to 31/12/2014. Patients were assigned raw score sum based on initial V/A, and ocular findings then classified into 5 categories for predicting final visual outcome based on ocular Trauma score (OTS. RESULT : We estimated final V/A in 77 cases of open globe injuries (64.93% had raw sc ore between 65.91 (category 3, 4 Six months after the injury, 42.85% patients of categories 1 (raw score 0 - 44 achieved V/A of PL/HM as compared to 17% in OTS study. 16 patients with raw compared to OTS study. We reported comparable visual outcome with OT S study except in category 1 & 2. CONCLUSION: OTS score is valuable in triage, patient counseling and decision making for the management of ocular trauma. We recommend that OTS should be used routinely for open globe injuries as it is a simple guide

  1. 12 CFR 516.10 - How does OTS compute time periods under this part?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false How does OTS compute time periods under this part? 516.10 Section 516.10 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES § 516.10 How does OTS compute time periods under this part? In computing...

  2. 12 CFR 516.170 - When will OTS conduct a meeting on an application?

    Science.gov (United States)

    2010-01-01

    ... application, or otherwise determines that a meeting will benefit the decision-making process. OTS may limit... inform the applicant and all commenters requesting a meeting of its decision to grant or deny a meeting request, or of its decision to conduct a meeting on its own initiative. (c) If OTS decides to conduct a...

  3. Use of thermal cycling to reduce adhesion of OTS coated coated MEMS cantilevers

    Science.gov (United States)

    Ali, Shaikh M.; Phinney, Leslie M.

    2003-01-01

    °Microelectromechanical systems (MEMS) have enormous potential to contribute in diverse fields such as automotive, health care, aerospace, consumer products, and biotechnology, but successful commercial applications of MEMS are still small in number. Reliability of MEMS is a major impediment to the commercialization of laboratory prototypes. Due to the multitude of MEMS applications and the numerous processing and packaging steps, MEMS are exposed to a variety of environmental conditions, making the prediction of operational reliability difficult. In this paper, we investigate the effects of operating temperature on the in-use adhesive failure of electrostatically actuated MEMS microcantilevers coated with octadecyltrichlorosilane (OTS) films. The cantilevers are subjected to repeated temperature cycles and electrostatically actuated at temperatures between 25°C and 300°C in ambient air. The experimental results indicate that temperature cycling of the OTS coated cantilevers in air reduces the sticking probability of the microcantilevers. The sticking probability of OTS coated cantilevers was highest during heating, which decreased during cooling, and was lowest during reheating. Modifications to the OTS release method to increase its yield are also discussed.

  4. "Merging Yoga and Occupational Therapy (MY-OT): A feasibility and pilot study".

    Science.gov (United States)

    Schmid, Arlene A; Puymbroeck, Marieke Van; Portz, Jennifer D; Atler, Karen E; Fruhauf, Christine A

    2016-10-01

    To examine the feasibility and benefits of the Merging Yoga and Occupational Therapy (MY-OT) intervention. This is the primary analysis of a non-controlled pretest-posttest pilot study to understand the feasibility and impact of MY-OT on balance, balance self-efficacy, and fall risk factor management in people with chronic stroke. University research laboratory. People with chronic stroke were included in the study if they: had sustained a fall or had fear of falling, were able to stand, and hand impaired balance and were at risk for falls (≤46 on the Berg Balance Scale (BBS)). Individuals completed an 8 week intervention that included 16 sessions of both yoga and group occupational therapy (OT). Yoga included physical postures, breathing exercises, and meditation. OT focused on post-stroke fall risk factor management. The BBS was used to assess balance, the Activities-specific Balance Confidence Scale (ABC) was used to measure balance self-efficacy. Five fall risk factor management scales were used. Overall, the intervention was considered feasible, as individuals were able to safely complete the intervention with little attrition and high attendance. Balance improved by 30% (p=0.002). Balance self-efficacy improved by 15% (p=0.034). Each of the five fall risk factor management scales improved, but only two significantly improved (Fall Prevention and Management Questionnaire, 29%, p=0.004 and Fall Prevention Strategy Survey, 42%, p=0.032). The results demonstrate that MY-OT is a potential intervention to improve multiple fall related outcomes for people with stroke. Therapists may consider these interventions for people with stroke, but additional research is warranted. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.

    Directory of Open Access Journals (Sweden)

    Jan Korte

    2016-12-01

    Full Text Available Trehalose biosynthesis is considered an attractive target for the development of antimicrobials against fungal, helminthic and bacterial pathogens including Mycobacterium tuberculosis. The most common biosynthetic route involves trehalose-6-phosphate (T6P synthase OtsA and T6P phosphatase OtsB that generate trehalose from ADP/UDP-glucose and glucose-6-phosphate. In order to assess the drug target potential of T6P phosphatase, we generated a conditional mutant of M. tuberculosis allowing the regulated gene silencing of the T6P phosphatase gene otsB2. We found that otsB2 is essential for growth of M. tuberculosis in vitro as well as for the acute infection phase in mice following aerosol infection. By contrast, otsB2 is not essential for the chronic infection phase in mice, highlighting the substantial remodelling of trehalose metabolism during infection by M. tuberculosis. Blocking OtsB2 resulted in the accumulation of its substrate T6P, which appears to be toxic, leading to the self-poisoning of cells. Accordingly, blocking T6P production in a ΔotsA mutant abrogated otsB2 essentiality. T6P accumulation elicited a global upregulation of more than 800 genes, which might result from an increase in RNA stability implied by the enhanced neutralization of toxins exhibiting ribonuclease activity. Surprisingly, overlap with the stress response caused by the accumulation of another toxic sugar phosphate molecule, maltose-1-phosphate, was minimal. A genome-wide screen for synthetic lethal interactions with otsA identified numerous genes, revealing additional potential drug targets synergistic with OtsB2 suitable for combination therapies that would minimize the emergence of resistance to OtsB2 inhibitors.

  6. 12 CFR 510.5 - Release of unpublished OTS information.

    Science.gov (United States)

    2010-01-01

    ... ORGANIZATIONAL REGULATIONS § 510.5 Release of unpublished OTS information. (a) Scope. (1) This section applies to... their official capacities. Examples of unpublished information include: (i) Information in the memory of...

  7. Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus).

    Science.gov (United States)

    Song, Zhimin; Larkin, Tony E; Malley, Maureen O'; Albers, H Elliott

    2016-05-01

    Social recognition is a fundamental requirement for all forms of social relationships. A majority of studies investigating the neural mechanisms underlying social recognition in rodents have investigated relatively neutral social stimuli such as juveniles or ovariectomized females over short time intervals (e.g., 2h). The present study developed a new testing model to study social recognition among adult males using a potent social stimulus. Flank gland odors are used extensively in social communication in Syrian hamsters and convey important information such as dominance status. We found that the recognition of flank gland odors after a 3min exposure lasted for at least 24h, substantially longer than the recognition of other social cues in rats and mice. Intracerebroventricular injections of OT and AVP prolonged the recognition of flank gland odor for up to 48h. Selective OTR but not V1aR agonists, mimicked these enhancing effects of OT and AVP. Similarly, selective OTR but not V1aR antagonists blocked recognition of the odors after 20min. In contrast, the recognition of non-social stimuli was not blocked by either the OTR or the V1aR antagonists. Our findings suggest both OT and AVP enhance social recognition via acting on OTRs and not V1aRs and that the recognition enhancing effects of OT and AVP are limited to social stimuli. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Recent optical activity of the blazar OT 355

    Science.gov (United States)

    Bachev, R.; Kurtenkov, A.; Nikolov, Y.; Spassov, B.; Boeva, S.; Latev, G.; Dimitrova, R. V. Munoz

    2017-06-01

    The Flat Spectrum Radio Quasar OT 355 (also known as 7C 173240.70+385949.00, z=0.975) was typically observed to be in the optical between 16th and 21th magnitude (CRTS, http://nesssi.cacr.caltech.edu/catalina/20011332/113321380764100137p.html).

  9. District heating and heat storage using the solution heat of an ammonia/water system

    International Nuclear Information System (INIS)

    Taube, M.; Peier, W.; Mayor, J.C.

    1976-01-01

    The article describes a model for the optimum use of the heat energy generated in a nuclear power station for district heating and heat storage taking account of the electricity and heat demand varying with time. (HR/AK) [de

  10. 12 CFR 502.60 - When will OTS adjust, add, waive, or eliminate a fee?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false When will OTS adjust, add, waive, or eliminate a fee? 502.60 Section 502.60 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY ASSESSMENTS AND FEES Fees § 502.60 When will OTS adjust, add, waive, or eliminate a fee? Under...

  11. Placental Expressions of CDKN1C and KCNQ1OT1 in Monozygotic Twins with Selective Intrauterine Growth Restriction.

    Science.gov (United States)

    Gou, Chenyu; Liu, Xiangzhen; Shi, Xiaomei; Chai, Hanjing; He, Zhi-Ming; Huang, Xuan; Fang, Qun

    2017-10-01

    CDKN1C and KCNQ1OT1 are imprinted genes that might be potential regulators of placental development. This study investigated placental expressions of CDKN1C and KCNQ1OT1 in monozygotic twins with and without selective intrauterine growth restriction (sIUGR). Seventeen sIUGR and fifteen normal monozygotic(MZ) twin pairs were examined. Placental mRNA expressions of CDKN1C and KCNQ1OT1 were detected by real-time fluorescent quantitative PCR. CDKN1C protein expression was detected by immunohistochemical assay and Western-blotting. In the sIUGR group, smaller fetuses had a smaller share of the placenta, and CDKN1C protein expression was significantly increased while KCNQ1OT1 mRNA expression was significantly decreased. The CDKN1C/KCNQ1OT1 mRNA ratio was lower in the larger fetus than in the smaller fetus (p < .05). In the control group, CDKN1C protein expression showed no difference between larger and smaller fetuses, while KCNQ1OT1 mRNA expression was significantly lower in the larger fetus, and the CDKN1C/KCNQ1OT1 mRNA ratio was higher in the larger fetus than in the smaller fetus (p < .05). Our findings showed that pathogenesis of sIUGR may be related to the co-effect of the up-regulated protein expression of CDKN1C and down-regulated mRNA expression of KCNQ1OT1 in the placenta.

  12. OT - Education for the health services of the future

    DEFF Research Database (Denmark)

    Hansen, Bodil Winther; Sørensen, Annette; Hove, Anne

    OT - Education for the health services of the future This presentation offers knowledge about which qualifications the health services and OT practice in general demand from Occupational Therapists. The study was developed in a wider context of the constant reflection within higher education...... as a result of the rapid pace of change in society. The Faculty of Occupational Therapy in Copenhagen wanted to enable the graduates in the best possible way to meet the employers’ demands as to qualifications. Furthermore, the aim was to develop and guarantee the quality of the educations offered...... by University College Oeresund. To express the level of education to be achieved in terms of competences and learning outcome, the study was inspired by the tuning process of educational structures in Europe, which is part of the Bologna process to integrate higher education area in Europe. The study is based...

  13. Gene expression profiles of prohibitin in testes of Octopus tankahkeei (ot-phb) revealing its possible role during spermiogenesis.

    Science.gov (United States)

    Mao, Hai-Tao; Wang, Da-Hui; Lan, Zhou; Zhou, Hong; Yang, Wan-Xi

    2012-05-01

    Prohibitin is essential for intracellular homeostasis and stabilization of mitochondrial respiratory chain complexes. To explore its functions during spermiogenesis of Octopus tankahkeei (O. tankahkeei), we have cloned and sequenced the cDNA of this mammalian PHB homologue (termed ot-PHB) from the testes of O. tankahkeei. The 1165 bp ot-phb cDNA contains a 100 bp 5' UTR, a 882 bp open reading frame and a 183 bp 3' UTR. The putative ot-PHB protein owns a transmembrane domain from 6 to 31 amino acid (aa) and a putative PHB domain from 26 to 178 aa. Protein alignment demonstrated that ot-PHB had 73.3, 73.6, 74.0, 75.1, and 45.4% identity with its homologues in Homo sapiens, Mus muculus, Danio rerio, Xenopus tropicalis and Trypanosoma brucei, respectively. Tissue distribution profile analysis revealed its presence in all the tissues examined. In situ hybridization in spermiogenic cells demonstrated that ot-phb was expressed moderately at the beginning of the spermiogenesis. The abundance of transcripts increased in intermediate spermatids and in drastically remodeling final spermatids. In mature spermatozoa, the residuary transcripts concentrated around the chondriosomal mantle where mitochondria assemble around. In summary, the expression of ot-phb during spermiogenesis implicates a potential function of this protein during mitochondrial ubiquitination. It is the first time to implicate the role of prohibitin in cephalopod spermiogenesis.

  14. Changeover Inference: Estimating the Relationship Between DT and OT Data

    National Research Council Canada - National Science Library

    Dippery, Kevin

    1997-01-01

    ... which has undergone developmental testing. Using a re-sampling method called the Bootstrap, the sampling variance and standard error of the changeover factor are calculated, as are confidence intervals for the OT failure rate of a new system...

  15. Nuclear waste disposal

    International Nuclear Information System (INIS)

    Schueller, W.

    1976-01-01

    The article cites and summarizes the papers on the topics: economic and ecological importance of waste management, reprocessing of nuclear fuel and recycling of uranium and plutonium, waste management and final storage, transports and organizational aspects of waste management, presented at this symposium. (HR/AK) [de

  16. 12 CFR 502.50 - What fees does OTS charge?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What fees does OTS charge? 502.50 Section 502.50 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY ASSESSMENTS AND FEES... consolidated with a savings association on the Consolidated Statement of Condition of the Thrift Financial...

  17. Spectroscopic Classification of MASTER OT J044212.20+230616.7

    Science.gov (United States)

    Shivvers, I.; Kelly, P. L.; Clubb, K. I.; Filippenko, A. V.

    2014-09-01

    We report that inspection of a CCD spectrum (range 330-1000 nm), obtained on September 22 UT with the 3-m Shane reflector (+ Kast) at Lick Observatory, shows that MASTER OT J044212.20+230616.7 (ATel #6484) is a Type IIn supernova.

  18. Doktoritööd : [2007, Janis Ešots, Signe Dobelniece

    Index Scriptorium Estoniae

    2007-01-01

    29. mail kaitseb Janis Ešots doktoritööd "Mullā Sadrā wujūd õpetus: müstitsismi ja filosoofia süntees"; 11. juunil kaitseb Signe Dobelniece doktoritööd "Kodutus Lätis: põhjused ja lahendused"

  19. The reactivity of anion-exchange resins by applying OT-for-OH exchange reaction in the equilibrium state

    International Nuclear Information System (INIS)

    Kano, Naoki; Nihei, Makoto; Imaizumi, Hiroshi

    1996-01-01

    In order to reveal the behavior of hydroxyl group in isotope exchange reaction, OT-for-OH exchange reaction between each anion-exchange resin (OH - form) and tritiated water (abbreviated as HTO water below) was observed at 80degC under the equilibrium. Anion-exchange resins used were Amberlite IRA-400, IRA-410 (both strongly basic), and IRA-94S (weakly basic). It can be thought that an HTO molecule dissociates into H + +OT - (or T + +OH - ). The activity of each resin based on OT-for-OH exchange reaction was measured with a liquid scintillation counter. From the above-mentioned, the following five were found. Isotope exchange reaction as 'atomic group' occurred between the OH group in each anion-exchange resin and the OT group in HTO water. The reactivity of strongly basic anion-exchange resin is larger than that of weakly basic one. The ratio of the reactivity of these resins can roughly be expressed as follows: (IRA-410): (IRA-400): (IRA-94S)=42: 7: 1. The degree of OT-for-OH exchange reaction may be smaller than that of T-for-H exchange reaction. The method used and results obtained in this work may be helpful to obtain the data for the prevention of T-contamination, especially to obtain the data from certain atomic groups including T. (author)

  20. Over-expression of the mycobacterial trehalose-phosphate phosphatase OtsB2 results in a defect in macrophage phagocytosis associated with increased mycobacterial-macrophage adhesion

    Directory of Open Access Journals (Sweden)

    Hao Li

    2016-11-01

    Full Text Available Trehalose-6-phosphate phosphatase (OtsB2 is involved in the OtsAB trehalose synthesis pathway to produce free trehalose and is strictly essential for mycobacterial growth. We wished to determine the effects of OtsB2 expression on mycobacterial phenotypes such as growth, phagocytosis and survival in macrophages. Mycobacterium bovis-BCG (BCG over-expressing OtsB2 were able to better survive in stationary phase. Over-expression of OtsB2 led to a decrease in phagocytosis but not survival in THP-1 macrophage-like cells, and this was not due to a decrease in general macrophage phagocytic activity. Surprisingly, when we investigated macrophage-mycobacterial interactions by flow cytometry and atomic force microscopy, we discovered that BCG over-expressing OtsB2 have stronger binding to THP-1 cells than wild-type BCG. These results suggest that altering OtsB2 expression has implications for mycobacterial host-pathogen interactions. Macrophage-mycobacteria phagocytic interactions are complex and merit further study.

  1. Inflatable capsule recovery raft using OTS pontoons and other components, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the proposed innovation is to research and study the feasibility of using pontoons (based on Off the Shelf (OTS) equipment) to make an inflatable...

  2. MASTER OT J072007.30+451611.6: Cataclysmic Variable with an Extreme Hot Spot

    Science.gov (United States)

    Denisenko, D.

    2018-05-01

    MASTER team has reported an unusual object MASTER OT J072007.30+451611.6 in ATel #11620 (T. Pogrosheva et al.). The object was observed at 17.0-17.2m during 9 minutes from 22:15:26 to 22:24:30 UT on 2018-04-26, but was below the detection limit (18.8m) 45 minutes before the first positive observation and 43 minutes after the last one. As noted by S. Otero in AAVSO VSX entry, MASTER OT J072007.30+451611.6 has an X-ray counterpart XMMSL2 J072007.4+451615.

  3. High-Amplitude, Rapid Photometric Variation of the New Polar Master OT J132104.0+560957.8

    Science.gov (United States)

    2015-02-05

    HIGH-AMPLITUDE, RAPID PHOTOMETRIC VARIATION OF THE NEW POLAR MASTER OT J132104.04+560957.8 LITTLEFIELD, COLIN;1,2 GARNAVICH, PETER;1 MAGNO, KATRINA;1...18.5 during each photometric cycle, becoming so faint that we could no longer detect it. The data showed a period of roughly 91 minutes with each...TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE High-Amplitude, Rapid Photometric Variation Of The New Polar Master OT

  4. MASTER-SAAO: contradictory SN and flaring OT

    Science.gov (United States)

    Balanutsa, P.; Lipunov, V.; Buckley, D.; Gorbovskoy, E.; Tiurina, N.; Kuznetsov, A.; Kornilov, V.; Gress, O.; Pogrosheva, T.; Shumkov, V.; Vladimirov, V.; Vlasenko, D.; Kuvshinov, D.; Gabovich, A.

    2017-07-01

    MASTER-SAAO auto-detection system ( Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L ) discovered OT source at (RA, Dec) = 03h 42m 50.70s , -01d 52m 28s.7 on 2017-07-01.1753UT with unfiltered (6 images), that contradicts to Ia type detected in ATEL #10240 , ATEL #10225 for ATLAS17dcl ( http://www.supernova.thistlethwaites.com/sn2017/sndate.html ). It is in 8.4"W,20"S of PGC135685 with Btc=15.13, Vgsr=2773 http://leda.univ-lyon1.fr/ledacat.cgi?PGC135685 Spectral observations are required.

  5. Solar energy system performance evaluation: Honeywell OTS 41, Shenandoah (Newman), Georgia

    Science.gov (United States)

    Mathur, A. K.; Pederson, S.

    1982-08-01

    The operation and technical performance of the Solar Operational Test Site (OTS 41) located at Shenandoah, Georgia, are described, based on the analysis of the data collected between January and August 1981. The following topics are discussed: system description, performance assessment, operating energy, energy savings, system maintenance, and conclusions. The solar energy system at OTS 41 is a hydronic heating and cooling system consisting of 702 square feet of liquid-cooled flat-plate collectors; a 1000-gallon thermal storage tank; a 3-ton capacity organic Rankine-cycle-engine-assisted air conditioner; a water-to-are heat exchanger for solar space heating; a finned-tube coil immersed in the storage tank to preheat water for a gas-fired hot water heater; and associated piping, pumps, valves, and controls. The solar system has six basic modes of operation and several combination modes. The system operation is controlled automatically by a Honeywell-designed microprocessor-based control system, which also provides diagnostics.

  6. Isolation and Pharmacological Characterization of α-Elapitoxin-Ot1a, a Short-Chain Postsynaptic Neurotoxin from the Venom of the Western Desert Taipan, Oxyuranus temporalis

    Directory of Open Access Journals (Sweden)

    Carmel M. Barber

    2016-02-01

    Full Text Available Taipans (Oxyuranus spp. are elapids with highly potent venoms containing presynaptic (β and postsynaptic (α neurotoxins. O. temporalis (Western Desert taipan, a newly discovered member of this genus, has been shown to possess venom which displays marked in vitro neurotoxicity. No components have been isolated from this venom. We describe the characterization of α-elapitoxin-Ot1a (α-EPTX-Ot1a; 6712 Da, a short-chain postsynaptic neurotoxin, which accounts for approximately 30% of O. temporalis venom. α-Elapitoxin-Ot1a (0.1–1 µM produced concentration-dependent inhibition of indirect-twitches, and abolished contractile responses to exogenous acetylcholine and carbachol, in the chick biventer cervicis nerve-muscle preparation. The inhibition of indirect twitches by α-elapitoxin-Ot1a (1 µM was not reversed by washing the tissue. Prior addition of taipan antivenom (10 U/mL delayed the neurotoxic effects of α-elapitoxin-Ot1a (1 µM and markedly attenuated the neurotoxic effects of α-elapitoxin-Ot1a (0.1 µM. α-Elapitoxin-Ot1a displayed pseudo-irreversible antagonism of concentration-response curves to carbachol with a pA2 value of 8.02 ± 0.05. De novo sequencing revealed the main sequence of the short-chain postsynaptic neurotoxin (i.e., α-elapitoxin-Ot1a as well as three other isoforms found in O. temporalis venom. α-Elapitoxin-Ot1a shows high sequence similarity (i.e., >87% with other taipan short-chain postsynaptic neurotoxins.

  7. Nedožité devadesátiny Milana Otáhala

    Czech Academy of Sciences Publication Activity Database

    Tůma, Oldřich

    2017-01-01

    Roč. 24, 1/2 (2017), s. 247-251 ISSN 1210-7050 Institutional support: RVO:68378114 Keywords : Milan Otáhal * obituary * historiography Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  8. 12 CFR 502.28 - How does OTS determine the organizational form component for a savings and loan holding company?

    Science.gov (United States)

    2010-01-01

    ... component for a savings and loan holding company? 502.28 Section 502.28 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY ASSESSMENTS AND FEES Assessments Savings and Loan Holding Companies... savings and loan holding company that OTS regulates under section 10(l) of the HOLA. OTS will compute your...

  9. Solar-energy-system performance evaluation: Honeywell OTS 44, Ocmulgee, Georgia

    Science.gov (United States)

    Mathur, A. K.; Pederson, S.

    1982-01-01

    The operation and technical performance of the solar operational test site (OTS 44) are described, based on data collected between April, 1981 and August, 1981. The following topics are discussed: system description, performance assessment, operating energy, energy savings, system maintenance, and conclusions. The solar energy system at OTS 44 is a hydronic heating and cooling system consisting of 5040 square feet of liquid cooled flat plate collectors; a 4000 gallon thermal storage tank; one 25 ton capacity organic Rankine cycle engine assisted water chillers; a forced draft cooling tower; and associated piping, pumps, valves, controls and heat rejection equipment. The solar system has eight basic modes of operation and several combination modes for providing space conditioning and hot water to the building. Data monitored during the 4 months of the operational test period found that the solar system collected 285 MMBtu of thermal energy of the total incident solar energy of 1040 MMBtu and provided 210 MMBtu for cooling and 10 MMBtu for heating and hot water. The net electrical energy saving due to the solar system was approximately 2600 kWh(e), and fossil energy saving was about 20 million Btu (MMBtu).

  10. In a changing society which elements and competencies is needed and demanded in the future OT education?

    DEFF Research Database (Denmark)

    Hansen, Bodil Winther; Sørensen, Annette

    to plan a curriculum, in order to enable OT graduates to meet employers’ demands in a rapidly changing society •The future OT profession. After 12 years of practising Problem Based Learning (PBL), the Faculty of Occupational Therapy wanted to develop the quality of the OT education offered by Metropolitan...... University College, Copenhagen. The object was to evaluate and develop the pedagogical practice, and to examine if the pedagogical concept prepares the students for the future in the best way possible. To describe the level of education to be achieved in terms of competences and learning outcome, the study...... was inspired by the Tuning Process of educational structures in Europe, which is part of the Bologna process to integrate higher education in Europe. The study is based on literature studies, quantitative and qualitative methods. All of these methods are suitable for uncovering competences demanded by practice...

  11. Optimal Diphthongs: An OT Analysis of the Acquisition of Spanish Diphthongs

    Science.gov (United States)

    Krause, Alice

    2013-01-01

    This dissertation investigates the acquisition of Spanish diphthongs by adult native speakers of English. The following research questions will be addressed: 1) How do adult native speakers of English pronounce sequences of two vowels in their L2 Spanish at different levels of acquisition? 2) Can OT learnability models, specifically the GLA,…

  12. LATERAL SURVIVAL: AN OT ACCOUNT

    Directory of Open Access Journals (Sweden)

    Moira Yip

    2004-12-01

    Full Text Available When laterals are the targets of phonological processes, laterality may or may not survive. In a fixed feature geometry, [lateral] should be lost if its superordinate node is eliminated by either the spreading of a neighbouring node, or by coda neutralization. So if [lateral] is under Coronal (Blevins 1994, it should be lost under Place assimilation, and if [lateral] is under Sonorant Voicing (Rice & Avery 1991 it should be lost by rules that spread voicing. Yet in some languages lateral survives such spreading intact. Facts like these argue against a universal attachment of [lateral] under either Coronal or Sonorant Voicing, and in favour of an account in terms of markedness constraints on feature-co-occurrence (Padgett 2000. The core of an OT account is that IFIDENTLAT is ranked above whatever causes neutralization, such as SHARE-F or *CODAF. laterality will survive. If these rankings are reversed, we derive languages in which laterality is lost. The other significant factor is markedness. High-ranked feature co-occurrence constraints like *LATDORSAL can block spreading from affecting laterals at all.

  13. 12 CFR 563b.200 - What actions may OTS take on my application?

    Science.gov (United States)

    2010-01-01

    ... appraiser may serve as an underwriter or selling agent, if you ensure that the appraiser is separate from the underwriter or selling agent affiliate and the underwriter or selling agent affiliate does not... convenience and needs of your communities after the conversion. (1) Based on this review, OTS may approve your...

  14. The R package otu2ot for implementing the entropy decomposition of nucleotide variation in sequence data

    Directory of Open Access Journals (Sweden)

    Alban eRamette

    2014-11-01

    Full Text Available Oligotyping is a novel, supervised computational method that classifies closely related sequences into oligotypes (OTs based on subtle nucleotide variations (Eren et al. 2013. Its application to microbial datasets has helped reveal ecological patterns which are often hidden by the way sequence data are currently clustered to define operational taxonomic units (OTUs. Here, we implemented the OT entropy decomposition procedure and its unsupervised version, Minimal Entropy Decomposition (MED; Eren et al. 2014, in the statistical programming language and environment, R. The aims are to facilitate the integration of computational routines, interactive statistical analyses, and visualization into a single framework. In addition, two complementary approaches are implemented: 1 An analytical method (the broken stick model is proposed to help identify oligotypes of low abundance that could be generated by chance alone and 2 a one-pass profiling (OP method, to efficiently identify those OTUs whose subsequent oligotyping would be most promising. These enhancements are especially useful for large datasets, where a manual screening of entropy analysis results and the creation of a full set of OTs may not be feasible. The package and procedures are illustrated by several tutorials and examples.

  15. Treatment of geographic atrophy by the topical administration of OT-551: results of a phase II clinical trial.

    Science.gov (United States)

    Wong, Wai T; Kam, Waynekid; Cunningham, Denise; Harrington, Molly; Hammel, Keri; Meyerle, Catherine B; Cukras, Catherine; Chew, Emily Y; Sadda, Srinivas R; Ferris, Frederick L

    2010-12-01

    To investigate the safety and preliminary efficacy of OT-551, a disubstituted hydroxylamine with antioxidant properties, for the treatment of geographic atrophy (GA), the advanced atrophic form of age-related macular degeneration (AMD). The study was a single-center, open-label phase II trial, enrolling 10 participants with bilateral GA. Topical 0.45% OT-551 was administered in one randomly assigned eye three times daily for 2 years. Safety measures were assessed by complete ophthalmic examination, fundus photography, and review of symptoms. The primary efficacy outcome measure was the change in best corrected visual acuity at 24 months. Secondary efficacy measures included changes in area of GA, contrast sensitivity, microperimetry measurements, and total drusen area from baseline. Study drug was well tolerated and was associated with few adverse events. The mean change in BCVA at 2 years was +0.2 ± 13.3 letters in the study eyes and -11.3 ± 7.6 letters in fellow eyes (P = 0.0259). However, no statistically significant differences were found between the study and fellow eyes for all other secondary outcome measures. OT-551 was well tolerated by study participants and was not associated with any serious adverse effects. Efficacy measurements in this small study indicate a possible effect in maintaining visual acuity. However, the absence of significant effects on other outcomes measures in this study suggests that OT-551, in the current concentration and mode of delivery, may have limited or no benefit as a treatment for GA (ClinicalTrials.gov number, NCT00306488).

  16. 78 FR 76768 - Removal of Transferred OTS Regulations Regarding Disclosure and Reporting of CRA-Related...

    Science.gov (United States)

    2013-12-19

    ... of competent jurisdiction, or by operation of law. \\1\\ Dodd-Frank Wall Street Reform and Consumer... the OTS was abolished by Title III of the Dodd-Frank Act. Part 390, subpart H is largely redundant of...

  17. Evaluation and selection of CASE tool for SMART OTS development

    International Nuclear Information System (INIS)

    Park, K. O; Seo, S. M.; Seo, Y. S.; Koo, I. S.; Jang, M. H.

    1999-01-01

    CASE(Computer-Aided Software Engineering) tool is a software that aids in software engineering activities such as requirement analysis, design, testing, configuration management, and project management. The evaluation and selection of commercial CASE tools for the specific software development project is not a easy work because the technical ability of an evaluator and the maturity of a software development organization are required. In this paper, we discuss selection strategies, characteristic survey, evaluation criteria, and the result of CASE tool selection for the development of SMART(System-integrated Modular Advanced ReacTor) OTS(Operator Training Simulator)

  18. VizieR Online Data Catalog: Follow-up photometry of M101 OT2015-1 (Blagorodnova+, 2017)

    Science.gov (United States)

    Blagorodnova, N.; Kotak, R.; Polshaw, J.; Kasliwal, M. M.; Cao, Y.; Cody, A. M.; Doran, G. B.; Elias-Rosa, N.; Fraser, M.; Fremling, C.; Gonzalez-Fernandez, C.; Harmanen, J.; Jencson, J.; Kankare, E.; Kudritzki, R.-P.; Kulkarni, S. R.; Magnier, E.; Manulis, I.; Masci, F. J.; Mattila, S.; Nugent, P.; Ochner, P.; Pastorello, A.; Reynolds, T.; Smith, K.; Sollerman, J.; Taddia, F.; Terreran, G.; Tomasella, L.; Turatto, M.; Vreeswijk, P. M.; Wozniak, P.; Zaggia, S.

    2017-07-01

    The location of M101-OT2015-1 has been serendipitously imaged by numerous telescopes and instruments over the last 15 years (from 2000 to 2015). Our best quality pre-discovery image (seeing of 0.55") is an r-band exposure at -3625 days pre-peak from the Canada-France-Hawaii Telescope (CFHT). The historical optical data for M101-OT was retrieved from the CFHT MegaPrime and CFHT12K/Mosaic, using single and combined exposures, Pan-STARRS-1/GPC1 (PS1), Isaac Newton Telescope/Wide Field Camera (INT/WFC), and Sloan Digital Sky Survey (SDSS) DR 10 (Ahn+ 2014, see V/147). Unfortunately, there are no HST images covering the location of the source. Post-discovery optical magnitudes were obtained from the reported followup astronomer's telegrams (ATels), Liverpool Telescope (LT), the Nordic Optical Telescope (NOT), and the Palomar P48 and P60 telescopes. The infrared data were retrieved from CFHT/WIRCam, UKIRT/WFCAM, and the Spitzer Infrared Array Camera in 3.6 and 4.5um as part of the SPitzer InfraRed Intensive Transients Survey (SPIRITS) (Kasliwal+, 2017ApJ...839...88K). Details of pre-discovery photometry and post-discovery optical photometry may be found in the Appendices Tables 1 and 2, respectively. We obtained spectra of M101-OT using a range of facilities in 2015 Feb-Jul. (3 data files).

  19. Mis mõtteid tekitab õpetaja kutsestandardi projekt? / Kerli Prass, Kalle Kalda, Loone Ots, Külli Arand

    Index Scriptorium Estoniae

    2013-01-01

    Vastasid SA Noored Kooli tuutor ja õpetajakoolituse koordinaator Kerli Prass, lastekaitse liidu president Loone Ots, Tartu haridustöötajate liidu esimees Kalle Kalda, Tallinna Saksa Gümnaasiumi klassiõpetaja Külli Arand

  20. 75 FR 181 - Application for Conversion From: (a) OTS-Regulated, State-Chartered Savings Association to...

    Science.gov (United States)

    2010-01-04

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision Application for Conversion From: (a) OTS-Regulated, State- Chartered Savings Association to Federal Savings Association; (b) National Bank, Commercial Bank, State Savings Bank, or Credit Union to Federal Savings Association; (c) State Mutual Holding...

  1. 75 FR 10560 - Application for Conversion From: (a) OTS-Regulated, State-Chartered Savings Association to...

    Science.gov (United States)

    2010-03-08

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision Application for Conversion From: (a) OTS-Regulated, State- Chartered Savings Association to Federal Savings Association; (b) National Bank, Commercial Bank, State Savings Bank, or Credit Union to Federal Savings Association; (c) State Mutual Holding...

  2. {sigma}{sup t}ot{sub e}eyy at e{sup +}e{sup -} colliders

    Energy Technology Data Exchange (ETDEWEB)

    Godbole, R.M. [Indian Institute of Science, Centre for Theoretical Studies, Bangalore (India); Pancheri, G. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati, Rome (Italy)

    2001-02-01

    In this talk are briefly summarized different models for {sigma}{sup t}ot{sub 2}y (e{sup +}e{sup -} {yields}yy{yields} hadrons) and contrast model predictions with the data. It will be then discussed the capability of the future e{sup +}e{sup -} and yy colliders to distinguish between various models and end with an outlook for future work.

  3. Návrh systému regulace vrtule stálých otáček

    OpenAIRE

    Líška, Lukáš

    2014-01-01

    Diplomová práca sa zaoberá problematikou návrhu elektrickej regulácie vrtule konštantných otáčok. Cieľom práce je ukázať postup návrhu regulátora na príklade vrtule DMP-3 pracujúcej s motorom Rotax 912 ULS, využitím vedomostí z mechaniky letu, elektrotechniky a automatizácie. V rámci práce bude poukázané na problematiku riadenia uhla nastavenia vrtule za použitia elektricky riadeného lineárneho aktuátora. Záver práce tvorí porovnanie výhod vrtule konštantných otáčok DMP-3 uvážením jej použiti...

  4. Transcriptional role of androgen receptor in the expression of long non-coding RNA Sox2OT in neurogenesis.

    Directory of Open Access Journals (Sweden)

    Valentina Tosetti

    Full Text Available The complex architecture of adult brain derives from tightly regulated migration and differentiation of precursor cells generated during embryonic neurogenesis. Changes at transcriptional level of genes that regulate migration and differentiation may lead to neurodevelopmental disorders. Androgen receptor (AR is a transcription factor that is already expressed during early embryonic days. However, AR role in the regulation of gene expression at early embryonic stage is yet to be determinate. Long non-coding RNA (lncRNA Sox2 overlapping transcript (Sox2OT plays a crucial role in gene expression control during development but its transcriptional regulation is still to be clearly defined. Here, using Bicalutamide in order to pharmacologically inactivated AR, we investigated whether AR participates in the regulation of the transcription of the lncRNASox2OTat early embryonic stage. We identified a new DNA binding region upstream of Sox2 locus containing three androgen response elements (ARE, and found that AR binds such a sequence in embryonic neural stem cells and in mouse embryonic brain. Our data suggest that through this binding, AR can promote the RNA polymerase II dependent transcription of Sox2OT. Our findings also suggest that AR participates in embryonic neurogenesis through transcriptional control of the long non-coding RNA Sox2OT.

  5. Spectroscopic Classification of MASTER OT J110707.62-052244.0 as a Type Ia Supernova

    Science.gov (United States)

    Zheng, W.; Kim, M.; Shivvers, I.; Yuk, H.; Filippenko, A. V.

    2015-11-01

    We report that inspection of a CCD spectrum (range 350-1050 nm) of MASTER OT J110707.62-052244.0 (ATel #8236), obtained on Nov. 11.57 UT with the Shane 3-m reflector (+ Kast spectrograph) at Lick Observatory, shows that the object is a normal Type Ia supernova roughly 1 week past maximum brightness.

  6. 78 FR 54401 - Removal of Transferred OTS Regulations Regarding Post-Employment Activities of Senior Examiners

    Science.gov (United States)

    2013-09-04

    ... F Street) on business days between 7 a.m. and 5 p.m. Please include your name, affiliation, address... section 6303(b) of the Intelligence Reform and Terrorism Prevention Act of 2004.\\4\\ This Act added a new... showing of good cause. After comparing the FDIC's rules with the transferred OTS rule relating to post...

  7. Caracterización de la comunidad de macroinvertebrados de la Quebrada Paloblanco de la Cuenca del Río Otún (Risaralda, Colombia)

    OpenAIRE

    Eleonora Bernal Pinilla; Duberney García García; Miguel Adriano Novoa Bravo; Atticus Pinzón Rodríguez

    2006-01-01

    Se realizó un estudio de las comunidades de macroinvertebrados presentes en la quebrada Paloblanco, ubicada en la cuenca del río Otún (Risaralda, Colombia). Los puntos de muestreo seleccionados corresponden a la cabecera y la zona cercana a la desembocadura en el río Otún, ambos con características geomorfológicas de corrientes de primer orden. En cada punto se colectaron los macroinvertebrados de las unidades funcionales hojarasca, epiliton, musgo y grava, junto con una muestra de deriva y f...

  8. Leczenie otępienia przy współistniejących schorzeniach internistycznych – wybrane zagadnienia

    Directory of Open Access Journals (Sweden)

    Alicja Klich-Rączka

    2012-12-01

    Full Text Available Celem poniższej pracy było przedstawienie dylematów związanych ze stosowaniem leków poprawiających funkcje poznawcze przy obecności innych schorzeń u ludzi starszych. Ze względu na powszechną w starości polipatologię otępienie, będące jednym z najistotniejszych problemów medycznych w tym okresie życia, rzadko występuje jako pojedyncze schorzenie – zwykle współistnieje z innymi chorobami. Leczenie otępienia jest zwykle połączone z terapią innych jednostek chorobowych, co wiąże się ze zwiększonym ryzykiem interakcji lekowych oraz działań niepożądanych. Dodatkowo ryzyko tych działań wzrasta z powodu zmian w farmakokinetyce wynikających z gorszej dystrybucji leków w organizmie oraz pogarszającej się z wiekiem wydolności wielonarządowej, czego konsekwencją może być upośledzony metabolizm i wydalanie leków. Spośród stosowanych w leczeniu otępienia inhibitorów acetylocholinesterazy interakcje najczęściej dotyczą donepezilu, co spowodowane jest jego metabolizmem w wątrobie przy udziale cytochromu P450, który równocześnie uczestniczy w metabolizmie wielu innych leków wykorzystywanych w terapii różnych schorzeń wieku starczego. Przeciwwskazaniami do stosowania inhibitorów acetylocholinesterazy są przede wszystkim: ciężka niewydolność wątroby, zespół chorego węzła zatokowego, zaburzenia rytmu i przewodnictwa, czynna choroba wrzodowa żołądka lub dwunastnicy, choroby powodujące utrudnienie odpływu moczu, napady drgawkowe, astma oskrzelowa/przewlekła obturacyjna choroba płuc. Działania niepożądane leków występują u kilku do kilkudziesięciu procent pacjentów, a u części z nich stanowią przeciwwskazania do kontynuowania terapii. Problem interakcji lekowych i działań niepożądanych jest często marginalizowany w leczeniu starszych pacjentów z otępieniem.

  9. MASTER OT J014638.27+041324.4 is a Young Type IIP Supernova

    Science.gov (United States)

    Zheng, W.; Kelly, P. L.; Clubb, K. I.; Filippenko, A. V.

    2013-12-01

    We report that a CCD spectrum (range 350-1000 nm) of MASTER OT J014638.27+041324.4 (Shurpakov et al., ATel #5630) was obtained on Dec 6.5 UT with the Shane 3-m reflector (+Kast spectrograph) at Lick Observatory. The spectrum shows a blue continuum and weak, broad hydrogen Balmer lines having P-Cyg profiles, indicating that the object is a young Type IIP supernova. Weak He I 587.6 nm is also present.

  10. Computer software design description for the Treated Effluent Disposal Facility (TEDF), Project L-045H, Operator Training Station (OTS)

    International Nuclear Information System (INIS)

    Carter, R.L. Jr.

    1994-01-01

    The Treated Effluent Disposal Facility (TEDF) Operator Training Station (OTS) is a computer-based training tool designed to aid plant operations and engineering staff in familiarizing themselves with the TEDF Central Control System (CCS)

  11. Eisma sadamahoone = Eisma port building / Mari Kurismaa ; kommenteerinud Krista Aren

    Index Scriptorium Estoniae

    Kurismaa, Mari, 1956-

    2015-01-01

    Eluruumid Eisma sadamahoones (Eisma küla, Vihula vald, Lääne-Virumaa). Sisekujunduse autorid Mari Kurismaa, Indrek Allmann; arhitekt Indrek Allmann (AB Pluss). Eesti Sisearhitektide Liidu aastapreemia 2014/2015 parima kodu eest. Lühidalt Mari Kurismaast ja Indrek Allmannist

  12. Rahumaa omandas Karumsi valmistaja / Harry Tuul

    Index Scriptorium Estoniae

    Tuul, Harry

    2007-01-01

    Indrek Rahumaa juhitav Eesti Investeerimisgrupp Alta Capital Partners ostis Läti piimatööstuse Rigas Piensaimnieksi. CV: Indrek Rahumaa. Diagramm: Majandusnäitajad. Vt. samas: Rahumaa omanduses suur hulk firmasid; Väinu Rozental. Indrek Rahumaa ostu järel võib Eestit pidada kohukesevabariigiks

  13. Life-cycle and genome of OtV5, a large DNA virus of the pelagic marine unicellular green alga Ostreococcus tauri.

    Directory of Open Access Journals (Sweden)

    Evelyne Derelle

    Full Text Available Large DNA viruses are ubiquitous, infecting diverse organisms ranging from algae to man, and have probably evolved from an ancient common ancestor. In aquatic environments, such algal viruses control blooms and shape the evolution of biodiversity in phytoplankton, but little is known about their biological functions. We show that Ostreococcus tauri, the smallest known marine photosynthetic eukaryote, whose genome is completely characterized, is a host for large DNA viruses, and present an analysis of the life-cycle and 186,234 bp long linear genome of OtV5. OtV5 is a lytic phycodnavirus which unexpectedly does not degrade its host chromosomes before the host cell bursts. Analysis of its complete genome sequence confirmed that it lacks expected site-specific endonucleases, and revealed the presence of 16 genes whose predicted functions are novel to this group of viruses. OtV5 carries at least one predicted gene whose protein closely resembles its host counterpart and several other host-like sequences, suggesting that horizontal gene transfers between host and viral genomes may occur frequently on an evolutionary scale. Fifty seven percent of the 268 predicted proteins present no similarities with any known protein in Genbank, underlining the wealth of undiscovered biological diversity present in oceanic viruses, which are estimated to harbour 200Mt of carbon.

  14. 12 CFR 502.29 - How does OTS determine the condition component for a savings and loan holding company?

    Science.gov (United States)

    2010-01-01

    ... for a savings and loan holding company? 502.29 Section 502.29 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY ASSESSMENTS AND FEES Assessments Savings and Loan Holding Companies-Calculation of Assessments § 502.29 How does OTS determine the condition component for a savings and loan...

  15. 12 CFR 502.26 - How does OTS calculate the semi-annual assessment for savings and loan holding companies?

    Science.gov (United States)

    2010-01-01

    ... assessment for savings and loan holding companies? 502.26 Section 502.26 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY ASSESSMENTS AND FEES Assessments Savings and Loan Holding Companies-Calculation of Assessments § 502.26 How does OTS calculate the semi-annual assessment for savings and loan...

  16. Kas ülikoolis õppimine on õige aeg lapse sünnitamiseks? / Ilona Opaal, Liis-Erliken Vinne, Tõnu Ots ... [jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad TLÜ anglistikaüliõpilane Ilona Opaal, TLÜ bioloogiaüliõpilane Liis-Erliken Vimme, psühholoog Tõnu Ots, filosoof Valdar Parve, Soome Instituudi direktor Jaana Vasama, psühholoog Tiia Lister, Treffneri Gümnaasiumi usu- ja filosoofiaõpetaja Toomas Jürgenstein

  17. Entraining IDyOT: timing in the information dynamics of thinking

    Directory of Open Access Journals (Sweden)

    Jamie Forth

    2016-10-01

    Full Text Available We present a novel hypothetical account of entrainment in music and language, in context of the Information Dynamics of Thinking model, IDyOT. The extended model affords an alternative view of entrainment, and its companion term, pulse, from earlier accounts. The model is based on hiearchical, statistical prediction, modeling expectations of both what an event will be and when it will happen. As such,it constitutes a kind of predictive coding, with a particular novel hypothetical implementation. Here, we focus on the model’s mechanism for predicting when a perceptual event will happen, given an existing sequence of past events, which maybe musical or linguistic. We propose a range of tests to validate or falsify the model, at various different levels of abstraction, and argue that computational modelling in particular, and this model in particular, can offer a means of providing limited but useful evidence for evolutionary hypotheses.

  18. Consonant harmony in Nilotic: contrastive specifications and Stratal OT

    Directory of Open Access Journals (Sweden)

    Sara Mackenzie

    2016-07-01

    Full Text Available Through analyses of dental harmony in four Nilotic languages, this paper argues both for contrastive representations and for a stratal version of Optimality Theory. Dholuo, Päri, Shilluk and Anywa all have dental harmony patterns which bar the co-occurrence of dental and alveolar segments. Details of the dental harmony patterning vary between languages and are tied to contrasts in the inventory. In Anywa, harmony is non-structure-preserving and an allophonic dental nasal surfaces in harmonic forms. This pattern can be analyzed in a stratal model of OT but leads to a ranking paradox if only a single level of evaluation is used. Further support for a stratal analysis can be found in the interaction between harmony and consonant mutation processes in the four languages. In Dholuo, harmony applies at the stem level and consonant mutation results in disharmonic surface forms in morphologically complex words. In Anywa, harmony applies later, at the word level, and words formed through consonant mutation must obey the dental harmony restrictions.

  19. Hıyarda (Cucumis sativus L. yabancı ot çıkış zamanın tahminine yönelik araştırmalar

    Directory of Open Access Journals (Sweden)

    Nihat Tursun

    2015-01-01

    Full Text Available İstatistiki modellerin geliştirilmesi için hıyar bitkisinde on bir önemli yabancı otun çıkış zamanın belirlenmesinde modellemeler yapılmıştır. Hıyar deneme arazisinde bulunan önemli yabancı otlar çıkış zamanlarına göre gruplara ayrılmıştır. Bu yabancı otlardan; Amaranthus retroflexus, Chenopodium album, Heliotropium europaeum, Polygonum aviculare ve Solanum nigrum erken, Convolvulus arvensis, Cyperus rotundus, Cynodon dactylon, Portulaca oleracea ve Sorghum halepense bütün vejetasyon boyunca ve Tribulus terrestris ise geç çimlenen yabancı ot türü olarak belirlenmiştir. Farklı doğrusal olmayan büyüme eğrileri (Chapman-Richard, Weibull, logistic, Gompertz ve cubic spline farklı yabancı ot türleri ve yıllar için çıkış yüzdeleri verileri esas alınarak uyarlanmıştır. Cubic splin model birçok yabancı ot türü için en iyi model olarak saptanmıştır.

  20. Transcriptional analysis and molecular dynamics simulations reveal the mechanism of toxic metals removal and efflux pumps in Lysinibacillus sphaericus OT4b.31

    KAUST Repository

    Shaw, Dario Rangel; Dussan, Jenny

    2017-01-01

    Lysinibacillus sphaericus strain OT4b.31 is a bacterium widely applied in bioremediation processes of hydrocarbon and metal polluted environments. In this study, we identified the molecular mechanism underlying the Pb2+ and Cr6+ resistance. Metal

  1. Balcas Eesti saeveski otsib uusi lahendusi / Taavi Linnamäe

    Index Scriptorium Estoniae

    Linnamäe, Taavi

    2004-01-01

    Balcas Eesti direktori Indrek Palumaa sõnul hakkab ettevõte tegelema tegevussorteeritud konstruktsioonimaterjalide tootmisega. Vt. samas: Indrek Palumaa. Ülikõrgele kerkinud toorme hind sunnib ettevõtjaid arvutama

  2. Tarand tegi Tarandit / Kalev Vilgats

    Index Scriptorium Estoniae

    Vilgats, Kalev

    2011-01-01

    Euroopa Parlamendi liikme Indrek Tarandi kandideerimisest Toomas Hendrik Ilvese vastaskandidaadina eelseisvatel presidendivalimistel. Vt. samas Andres G. Adamsoni karikatuur. Vt. ka lk. 4: Indrek tegi jälle Tarandit

  3. Purification, crystallization and preliminary X-ray diffraction studies of a putative UDP-N-acetyl-d-mannosamine dehydrogenase from Pyrococcus horikoshii OT3

    Energy Technology Data Exchange (ETDEWEB)

    Lokanath, Neratur K.; Pampa, Kudigana J.; Kamiya, Toshimi; Kunishima, Naoki, E-mail: kunisima@spring8.or.jp [Advanced Protein Crystallography Research Group, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan)

    2007-05-01

    A putative UDP-N-acetyl-d-mannosamine dehydrogenase from P. horikoshii OT3 has been crystallized in space group P2{sub 1}, with unit-cell parameters a = 80.28, b = 69.24, c = 83.10 Å, β = 114.4°. X-ray diffraction data have been collected to 1.80 Å resolution. A putative UDP-N-acetyl-d-mannosamine dehydrogenase from Pyrococcus horikoshii OT3, an essential enzyme for polysaccharide biosynthesis, has been overexpressed in Escherichia coli and purified. Crystals were obtained using the oil-microbatch method at 291 K. A native data set extending to 1.8 Å resolution has been collected and processed in space group P2{sub 1}. Assuming the presence of a dimer in the asymmetric unit, the V{sub M} value is calculated to be 2.3 Å{sup 3} Da{sup −1}, which is consistent with the result of a dynamic light-scattering experiment that shows a dimeric state of the protein in solution.

  4. Zastosowanie jakościowej analizy profilu wykonania skali ACE-III w diagnostyce różnicowej chorób otępiennych

    Directory of Open Access Journals (Sweden)

    Emilia J. Sitek

    2017-03-01

    Full Text Available Skala Addenbrooke’s Cognitive Examination III (ACE-III jest poszerzonym narzędziem przesiewowej oceny funkcji poznawczych, użytecznym we wczesnym wykrywaniu zaburzeń poznawczych, wstępnej diagnostyce różnicowej zespołów otępiennych oraz monitorowaniu postępu choroby. ACE-III ocenia uwagę i orientację, pamięć, fluencję słowną, funkcje językowe i wzrokowo-przestrzenne. Skala może być używana przez lekarzy i psychologów, zarówno jako narzędzie przesiewowe, jak i jako wstęp do kompleksowej oceny neuropsychologicznej. ACE-III zawiera również krótsze narzędzie, Mini-ACE, które w razie potrzeby może być stosowane niezależnie. W niniejszej pracy ACE-III porównano z innymi najbardziej popularnymi skalami przesiewowej oceny funkcji poznawczych: Mini-Mental State Examination (MMSE oraz Montrealską Skalą Oceny Funkcji Poznawczych (Montreal Cognitive Assessment, MoCA. Następnie omówiono przydatność kliniczną analizy profilu wykonania ACE-III w  diagnostyce różnicowej wybranych chorób neurozwyrodnieniowych. Zaprezentowano profile wykonania ACE-III typowe dla choroby Alzheimera (zarówno o wczesnym, jak i o późnym początku, zwyrodnienia czołowo-skroniowego, choroby Parkinsona, atypowych zespołów parkinsonowskich oraz otępienia naczyniopochodnego. Spośród atypowych wariantów choroby Alzheimera uwzględniono zanik korowy tylny, wariant logopeniczny afazji pierwotnej postępującej i wariant czołowy. Spośród podstawowych wariantów zwyrodnienia czołowo-skroniowego przedstawiono wariant behawioralny otępienia czołowo- -skroniowego oraz niepłynny i semantyczny wariant afazji pierwotnej postępującej. Wreszcie spośród zespołów parkinsonizm plus omówiono otępienie z ciałami Lewy’ego, zanik wieloukładowy, postępujące porażenie ponadjądrowe i zwyrodnienie korowo-podstawne.

  5. Melchior: Eesti tulevane ikoon / Jaan Martinson

    Index Scriptorium Estoniae

    Martinson, Jaan, 1960-

    2010-01-01

    Tutvustus: Hargla, Indrek, pseud. Apteeker Melchior ja Oleviste mõistatus : kriminaalromaan vanast Tallinnast. Tallinn : Varrak, 2010 ; Hargla, Indrek, pseud. Apteeker Melchior ja Rataskaevu viirastus : kriminaalromaan vanast Tallinnast. Tallinn : Varrak, 2010

  6. Crystallization and preliminary X-ray analysis of PH1010 from Pyrococcus horikoshii OT3, a member of the archaeal DUF54 family of proteins

    International Nuclear Information System (INIS)

    Shirokane, Michio; Sawano, Yoriko; Miyazono, Ken-ichi; Nagata, Koji; Tanokura, Masaru

    2007-01-01

    PH1010, a DUF54-family protein from the hyperthermophilic archaeon P. horikoshii OT3, was crystallized and X-ray diffraction data were collected to 1.90 Å resolution. PH1010 from Pyrococcus horikoshii OT3, a member of the archaeal DUF54 family of proteins, was expressed, purified and crystallized. Crystallization was performed by the sitting-drop vapour-diffusion method using PEG 3350 as the precipitant. The crystal diffracted X-rays to 1.90 Å resolution using a synchrotron-radiation source. The space group of the crystal was determined to be P2 1 2 1 2 1 , with unit-cell parameters a = 46.9, b = 49.5, c = 132.7 Å. The crystal contained two PH1010 molecules in the asymmetric unit (V M = 2.4 Å 3 Da −1 ) and had a solvent content of 48%

  7. Purification, crystallization and preliminary X-ray crystallographic analysis of the archaeal phosphoglycerate mutase PH0037 from Pyrococcus horikoshii OT3

    Energy Technology Data Exchange (ETDEWEB)

    Lokanath, Neratur K.; Kunishima, Naoki, E-mail: kunisima@spring8.or.jp [Advanced Protein Crystallography Research Group, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan)

    2006-08-01

    The archaeal phosphoglycerate mutase PH0037 from P. horikoshii OT3 has been crystallized in space group R32, with unit-cell parameters a = 155.62, c = 230.35 Å. A 2.2 Å resolution data was collected at SPring-8 beamline BL26B1. Phosphoglycerate mutases catalyze the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in glycolysis and gluconeogenesis pathways. The archaeal phosphoglycerate mutase PH0037 from Pyrococcus horikoshii OT3 has been overexpressed in Escherichia coli and purified. Crystals were obtained using the oil-microbatch method at 291 K. A native data set extending to a resolution of 2.2 Å has been collected and processed in space group R32. Assuming the presence of a dimer in the asymmetric unit, the V{sub M} value is calculated to be 3.0 Å{sup 3} Da{sup −1}, consistent with the dynamic light-scattering experiment result, which shows a dimeric state of the protein in solution. Molecular-replacement trials using the crystal structure of Bacilllus stearothermophilus phosphoglycerate mutase as a search model did not provide a satisfactory solution, indicating substantially different structures of these two phophoglycerate mutases.

  8. Uusi treenimisharjumusi : 500 krooli enne tööd / Risto Tankler

    Index Scriptorium Estoniae

    Tankler, Risto

    2006-01-01

    Ajakirja Sport+ toimetaja Lauri Tankleri ja Di peatoimetaja Kristjan Kaljundi muljeid ujumistreeningust. Vt. samas ka intervjuud Eesti Ujumisliidu presidendi ja viimase aja Eesti edukaima meesujuja Indrek Seiga. Lisaks Indrek Sei 8 nõuannet

  9. Overexpression, purification, crystallization and preliminary crystallographic studies of a hyperthermophilic adenylosuccinate synthetase from Pyrococcus horikoshii OT3

    International Nuclear Information System (INIS)

    Wang, Xiaoying; Akasaka, Ryogo; Takemoto, Chie; Morita, Satoshi; Yamaguchi, Machiko; Terada, Takaho; Shirozu, Mikako; Yokoyama, Shigeyuki; Chen, Shilin; Si, Shuyi; Xie, Yong

    2011-01-01

    A hyperthermophilic adenylosuccinate synthetase from P. horikoshii OT3, which is 90–120 amino acids shorter than those from the vast majority of organisms, was expressed, purified and crystallized and X-ray diffraction data were collected to 2.5 Å resolution. Adenylosuccinate synthetase (AdSS) is a ubiquitous enzyme that catalyzes the first committed step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP) in the purine-biosynthetic pathway. Although AdSS from the vast majority of organisms is 430–457 amino acids in length, AdSS sequences isolated from thermophilic archaea are 90–120 amino acids shorter. In this study, crystallographic studies of a short AdSS sequence from Pyrococcus horikoshii OT3 (PhAdSS) were performed in order to reveal the unusual structure of AdSS from thermophilic archaea. Crystals of PhAdSS were obtained by the microbatch-under-oil method and X-ray diffraction data were collected to 2.50 Å resolution. The crystal belonged to the trigonal space group P3 2 12, with unit-cell parameters a = b = 57.2, c = 107.9 Å. There was one molecule per asymmetric unit, giving a Matthews coefficient of 2.17 Å 3 Da −1 and an approximate solvent content of 43%. In contrast, the results of native polyacrylamide gel electrophoresis and analytical ultracentrifugation showed that the recombinant PhAdSS formed a dimer in solution

  10. Conservation of Repeats at the Mammalian KCNQ1OT1-CDKN1C Region Suggests a Role in Genomic Imprinting

    Directory of Open Access Journals (Sweden)

    Marcos De Donato

    2017-06-01

    Full Text Available KCNQ1OT1 is located in the region with the highest number of genes showing genomic imprinting, but the mechanisms controlling the genes under its influence have not been fully elucidated. Therefore, we conducted a comparative analysis of the KCNQ1/KCNQ1OT1-CDKN1C region to study its conservation across the best assembled eutherian mammalian genomes sequenced to date and analyzed potential elements that may be implicated in the control of genomic imprinting in this region. The genomic features in these regions from human, mouse, cattle, and dog show a higher number of genes and CpG islands (detected using cpgplot from EMBOSS, but lower number of repetitive elements (including short interspersed nuclear elements and long interspersed nuclear elements, compared with their whole chromosomes (detected by RepeatMasker. The KCNQ1OT1-CDKN1C region contains the highest number of conserved noncoding sequences (CNS among mammals, where we found 16 regions containing about 38 different highly conserved repetitive elements (using mVista, such as LINE1 elements: L1M4, L1MB7, HAL1, L1M4a, L1Med, and an LTR element: MLT1H. From these elements, we found 74 CNS showing high sequence identity (>70% between human, cattle, and mouse, from which we identified 13 motifs (using Multiple Em for Motif Elicitation/Motif Alignment and Search Tool with a significant probability of occurrence, 3 of which were the most frequent and were used to find transcription factor–binding sites. We detected several transcription factors (using JASPAR suite from the families SOX, FOX, and GATA. A phylogenetic analysis of these CNS from human, marmoset, mouse, rat, cattle, dog, horse, and elephant shows branches with high levels of support and very similar phylogenetic relationships among these groups, confirming previous reports. Our results suggest that functional DNA elements identified by comparative genomics in a region densely populated with imprinted mammalian genes may be

  11. Crystallization and preliminary X-ray analysis of PH1010 from Pyrococcus horikoshii OT3, a member of the archaeal DUF54 family of proteins

    Energy Technology Data Exchange (ETDEWEB)

    Shirokane, Michio; Sawano, Yoriko; Miyazono, Ken-ichi; Nagata, Koji; Tanokura, Masaru, E-mail: amtanok@mail.ecc.u-tokyo.ac.jp [Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657 (Japan)

    2007-06-01

    PH1010, a DUF54-family protein from the hyperthermophilic archaeon P. horikoshii OT3, was crystallized and X-ray diffraction data were collected to 1.90 Å resolution. PH1010 from Pyrococcus horikoshii OT3, a member of the archaeal DUF54 family of proteins, was expressed, purified and crystallized. Crystallization was performed by the sitting-drop vapour-diffusion method using PEG 3350 as the precipitant. The crystal diffracted X-rays to 1.90 Å resolution using a synchrotron-radiation source. The space group of the crystal was determined to be P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 46.9, b = 49.5, c = 132.7 Å. The crystal contained two PH1010 molecules in the asymmetric unit (V{sub M} = 2.4 Å{sup 3} Da{sup −1}) and had a solvent content of 48%.

  12. Geología de la zona de influencia de la falla otú en el distrito minero segovia-remedios

    Directory of Open Access Journals (Sweden)

    MILTON ÁLVAREZ GALINDEZ

    2007-01-01

    Full Text Available Se presenta la caracterización geológica y estructural de la zona de influencia de la falla Otú en jurisdicción del distrito minero Segovia-Remedios. Además, se proponen controles mecánicos para las mineralizaciones auríferas, que si bien son compatibles, en parte, con un modelo de depósitos de oro orogénico, dejan abiertas otras posibles interpretaciones

  13. Nordic Hotel Forum - osake Narva maantee põhjafassaadist / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2008-01-01

    Nordic Hotel Forum Viru väljak 3 Tallinnas. Arhitekt Indrek Allmann. Ehituse peatöövõtja AS Merko Ehitus. Indrek Allmann hoone arhitektuurist, fassaadigraafikast, linnaruumist hotelli ümber. 7 värv. välisvaadet

  14. Nordic Hotel Forum - tshast severnogo fasada narvskogo shosse / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2008-01-01

    Nordic Hotel Forum Viru väljak 3 Tallinnas. Arhitekt Indrek Allmann. Ehituse peatöövõtja AS Merko Ehitus. Indrek Allmann hoone arhitektuurist, fassaadigraafikast, linnaruumist hotelli ümber. 7 värv. välisvaadet, foto arhitektist

  15. Vahejuhtum kassas / Krister Kivi

    Index Scriptorium Estoniae

    Kivi, Krister, 1975-

    2008-01-01

    Alta Capitali juhist Indrek Rahumaa karjäärist ja varasematest tehingutest. Oliver Kruuda firmade Kalev ja Tere müügiläbirääkimiste katkemine võib Rahumaale kaasa tuua 141 miljoni kroonise finantskaotuse. Lisa: Indrek Rahumaa

  16. Eesti Lähimineviku Okupatsioonide Muuseumi arhitektuurivõistlus : okupatsiooni igaveseks jäädvustamiseks = Architectural Competition of the Museum of Recent Past Occupations in Estonia : for Eternal Remembrance of the Occupation / Leonhard Lapin

    Index Scriptorium Estoniae

    Lapin, Leonhard, 1947-

    2001-01-01

    Zürii koosseis, võistlusest, võidutööst. Preemiad: I - Indrek Peil, Siiri Vallner; II - Tiina Teng, Peeter Loo; III - Reio Avaste; ostud - Andres Kask ning Markus Kaasik, Kalle Komissarov, Andres Ojari, Indrek Tiigi ja Ilmar Valdur. 5 ill.

  17. A global outer-rise/outer-trench-slope (OR/OTS) earthquake study

    Science.gov (United States)

    Wartman, J. M.; Kita, S.; Kirby, S. H.; Choy, G. L.

    2009-12-01

    Using improved seismic, bathymetric, satellite gravity and other geophysical data, we investigated the seismicity patterns and focal mechanisms of earthquakes in oceanic lithosphere off the trenches of the world that are large enough to be well recorded at teleseismic distances. A number of prominent trends are apparent, some of which have been previously recognized based on more limited data [1], and some of which are largely new [2-5]: (1) The largest events and the highest seismicity rates tend to occur where Mesozoic incoming plates are subducting at high rates (e.g., those in the western Pacific and the Banda segment of Indonesia). The largest events are predominantly shallow normal faulting (SNF) earthquakes. Less common are reverse-faulting (RF) events that tend to be deeper and to be present along with SNF events where nearby seamounts, seamount chains and other volcanic features are subducting [Seno and Yamanaka, 1996]. Blooms of SNF OR/OTS events usually occur just after and seaward of great interplate thrust (IPT) earthquakes but are far less common after smaller IPT events. (2) Plates subducting at slow rates (Chile, the Ninety East Ridge in Sumatra, and the D’Entrecastaux Ridge in Vanuatu).

  18. Järve Keskus : Tallinn, Pärnu mnt. 236 = Järve Centre : 236 Pärnu Rd., Tallinn / Jaak Huimerind

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2003-01-01

    Projekteerija: Arhitektuuribüroo Studio Paralleel. Arhitektid Jaak Huimerind, Indrek Saarepera. Kaastöötajad Kristi Põldme, Indrek Laos, Reet Viigipuu. Avalike ruumide sisekujundus: Mari Kurismaa. Konstruktiivne osa: E-Inseneribüroo. Projekt 2000-2002, valmis 2002. Asendi-, I ja II korruse plaan, 6 vaadet

  19. Characterization of an immunodominant cancer-specific O-glycopeptide epitope in murine podoplanin (OTS8)

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Schjoldager, Katrine T; Cló, Emiliano

    2010-01-01

    antibody 237, developed to a spontaneous murine fibrosarcoma, was shown to be directed to murine podoplanin (OTS8) with truncated Tn O-glycans. Our understanding of such cancer-specific auto-antibodies to truncated glycoforms of glycoproteins is limited. Here we have investigated immunogenicity...... of a chemoenzymatically produced Tn-glycopeptide derived from the putative murine podoplanin O-glycopeptide epitope. We found that the Tn O-glycopeptide was highly immunogenic in mice and produced a Tn-glycoform specific response with no reactivity against unglycosylated peptides or the O-glycopeptide with extended O......-glycan (STn and T glycoforms). The immunodominant epitope was strictly dependent on the peptide sequence, required Tn at a specific single Thr residue (Thr(77)), and antibodies to the epitope were not found in naive mice. We further tested a Tn O-glycopeptide library derived from human podoplanin...

  20. Smarten Logistics lakub haavu / Lemmi Kann

    Index Scriptorium Estoniae

    Kann, Lemmi

    2007-01-01

    Ettevõtjate Armin Kõomägi, Sven Mansbergi ja Indrek Prantsi logistikafirma Smarten on teeninduse kvaliteedi tõttu kaotanud mitmeid tähtsaid kliente. Vt. samas: Tallinna Kaubamaja: Smarteni pakutavad hinnad on liiga soolased; Koos juba üle 13 aasta; Huvid kinnisvaraäris. Kommenteerib Indrek Prants

  1. A Otávia do Pseudo-Sêneca: tradução, estudo introdutório e notas

    OpenAIRE

    Fernanda Vieira Gôzo

    2016-01-01

    Esta pesquisa de mestrado objetivou o estudo da peça latina Otávia do Pseudo-Sêneca, que inclui uma tradução para o português, acompanhada de notas e de um estudo introdutório. Este trabalho centrou-se em apontar o que se têm discutido entre os estudiosos de literatura clássica em relação à peça. Foi pertinente para esse expediente uma análise do gênero praetexta, do qual faz parte esta peça, considerando as divergências entre praetexta republicana e imperial, bem como a observação de como a ...

  2. Kassett moosiks! / Priidu Beier

    Index Scriptorium Estoniae

    Beier, Priidu, 1957-

    1997-01-01

    Arvustus: Kassett 1995 / koost. Elo Vee. Tallinn : Eesti Raamat, 1996.Sisu: Kätlin Kätlin. Larii-laree; Kuningas, Madis-Mats. Sõna täüs aiga; Alt, Mai. Laule härjapõlvlase päevaraamatust; A. C. Homseni; Zipp, Lemme. Kirja pandud paberile; Ryytle, Indrek [Rüütle, Indrek]. Deani masin

  3. Databáze a generování testovacích otázek

    OpenAIRE

    Rejko, Peter

    2008-01-01

    Cílem bakalářské práce je vytvoření databáze testovacích otázek a jejich generování. Je rozdělená na teoretickou a praktickou část. V teoretické jsou popsané nástroje se zaměřením na tvorbu databází jazyku HTML, PHP a databázový server MySQL. Praktická část obsahuje vytvořenou aplikaci a zpracování. Jazyk PHP podporuje programování na základě modulárního paradigmatu - to znamená, že každý vytvořený modul má svoji úlohu. Aplikace obsahuje modul zabezpečující přihlášení a výběr dalšího modulu n...

  4. Short outlines of books by Estonian authors / Brita Melts and Rutt Hinrikus

    Index Scriptorium Estoniae

    Melts, Brita

    2011-01-01

    Arvustus: Vadi, Urmas. Kirjad tädi Annele. Pärnu : Jumalikud Ilmutused, 2010 ; Sommer, Lauri. Kolm yksiklast. Tallinn : Menu Kirjastus, 2010 ; Hargla, Indrek. Apteeker Melchior ja Oleviste mõistatus. Tallinn : Varrak, 2010 ; Hargla, Indrek. Apteeker Melchior ja Rataskaevu viirastus. Tallinn : Varrak, 2010 ; Pihelgas, Carolina. Metsas algavad hääled. Tallinn : Eesti Keele Sihtasutus, 2010

  5. "Tõde ja õigus" ilmutab end prantslastele : [vestlusring A. H. Tammsaare peateose tõlkijatega] / Jean Pascal Ollivry, Eva Toulouze, Jean-Pierre Minaudier ; vestlust juhtinud Tiina Väljaste

    Index Scriptorium Estoniae

    Ollivry, Jean Pascal

    2010-01-01

    2009. a. ilmus kirjastus Gaïa väljaandel "Tõde ja õigus" kolm esimest köidet: "La colline-du-voleur", "Indrek" (mõlemad tõlkis J. P. Ollivry) ja "Jours d'emeutes" (tlk. J.-P. Minaudier). E. Toulouze tõlgib romaani 4. osa ("Indrek et Karin") ning J. P. Ollivry 5. osa

  6. Kalevi kommivabrik läks Luksemburgi investeerimisfondile / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2007-01-01

    Kalevi ja Tere omandanud Luksemburgis registreeritud fondi Alta Capital Partners S.C.A. osanikud on 80% ulatuses Indrek Rahumaa, Andres Rätsepp, Jaak Raid ja Marius Binkevicius, 20% osakutest kuulub Briti varahaldusfirmale Bonfield Asset Management. Fondi hakkab haldama Läti firma Alta Capital Partners SIA. Skeemid: Mis Oliver Kruudale alles jäi? Mida Indrek Rahumaa ostis

  7. Evaluación de la diversidad de bacterias degradadoras de hidrocarburos aisladas de suelos de las cuencas de los ríos Otún y La Vieja / Evaluation of hydrocarbon degrading bacteria diversity isolated from soils of Otún and La Vieja river basins

    OpenAIRE

    Yanine Suárez, Habib Fernando

    2010-01-01

    Se evaluó el efecto del uso del suelo, sobre la densidad y diversidad de bacterias degradadoras de hidrocarburos (HC). Se seleccionaron los usos: bosque, pastizal y cafetal en la cuenca del río La Vieja (Valle del Cauca y Quindío), y bosque, cebollar y plantación forestal en la cuenca del río Otún (Risaralda) y se realizaron dos eventos de muestreo. La densidad se evaluó mediante la técnica de NMP en medio Bushnell-Hass, suplementado con diesel y usando XTT como indicador de actividad. Las ba...

  8. A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

    Science.gov (United States)

    Liu, Xiaohua; Kelsoe, John R; Greenwood, Tiffany A

    2016-01-01

    Bipolar disorder is a heterogeneous mood disorder associated with several important clinical comorbidities, such as eating disorders. This clinical heterogeneity complicates the identification of genetic variants contributing to bipolar susceptibility. Here we investigate comorbidity of eating disorders as a subphenotype of bipolar disorder to identify genetic variation that is common and unique to both disorders. We performed a genome-wide association analysis contrasting 184 bipolar subjects with eating disorder comorbidity against both 1370 controls and 2006 subjects with bipolar disorder only from the Bipolar Genome Study (BiGS). The most significant genome-wide finding was observed bipolar with comorbid eating disorder vs. controls within SOX2-OT (p=8.9×10(-8) for rs4854912) with a secondary peak in the adjacent FXR1 gene (p=1.2×10(-6) for rs1805576) on chromosome 3q26.33. This region was also the most prominent finding in the case-only analysis (p=3.5×10(-7) and 4.3×10(-6), respectively). Several regions of interest containing genes involved in neurodevelopment and neuroprotection processes were also identified. While our primary finding did not quite reach genome-wide significance, likely due to the relatively limited sample size, these results can be viewed as a replication of a recent study of eating disorders in a large cohort. These findings replicate the prior association of SOX2-OT with eating disorders and broadly support the involvement of neurodevelopmental/neuroprotective mechanisms in the pathophysiology of both disorders. They further suggest that different clinical manifestations of bipolar disorder may reflect differential genetic contributions and argue for the utility of clinical subphenotypes in identifying additional molecular pathways leading to illness. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Traditsiooniliselt ja pluralistlikult / Epp Annus

    Index Scriptorium Estoniae

    Annus, Epp, 1969-

    1996-01-01

    Nüpli kevadkool (seminari 'Traditsioon ja pluralism' järg põhirõhuga kirjandusloole), korraldajateks Underi ja Tuglase Kirjanduskeskus, Eesti Kirjandusmuuseum ja Tartu Ülikooli eesti kirjandusloo uurimisgrupp. Ettekanded: Loone Ots. Kuninganna jalad ehk Non sciunt, se scient. Eesti kirjandust välistudengitele; Kristi Metste. Tubli pioneer Kampmaa; Peep Ehasalu. 'Kiired' ja soomlased; Sirje Olesk. Kodu- ja väliseesti kahekõne 1950.-1960. aastatel; Marin Laak. Kriitikateos kirjandusloos : näide 1924. aastast (Valmar Adamsi arvustus Jaan Kärneri romaani 'Bianka ja Ruth' puhul); Ene-Reet Soovik. Koed, põimed ja takerdused : Ants Orase tõlkekriitikast ja -praktikast; Epp Annus. Anakroonilised võitlused romaanis 'Tõde ja õigus'; Luule Epner. Kahe 'Libahundi' vahel : draama ja teater 1960.-70ndate vahetusel, põikega proosasse; Toomas Liivamägi. Mõned vulgariseeringud (20. sajandi modernism energia jäävuse seadusest lähtudes); Toomas Muru. Paabeli torn ja Gooti katedraal; Aare Pilv. Kirjandusloolisus kui hoiak; Indrek Särg - Sven Kivisildnik. Eesti gayluule järjekordne algus; Rutt Hinrikus. Reed Morn, andekas parasiit; Kajar Pruul. Ühe kunstiteose analüüs (Sven Kivisildniku luuletus 'Eesti Nõukogude Kirjanike Liit'); Ele Süvalep. Modernist Jaan Oks

  10. Sadamaala konkurss : Tallinna kesklinnaga piirneva mereäärse ala parima linnaehitusliku kontseptsiooni saamiseks korraldatud arhitektuurivõistlus / Andres Alver, Margus Koot, Arvo Rikkinen...[jt.] ; interv. Triin Ojari

    Index Scriptorium Estoniae

    2000-01-01

    Zürii liikmed konkursist, premeeritud töödest. Preemiad: I - Villem Tomiste, Veronika Valk; II - Illimar Truverk, Indrek Järve, Mattias Agabus, Tiit Sild, Karri Tiigisoon ning Toomas Paaver, Lauri Saar; III - Ivar Lubjak, Maria Pukk; ostud: Ott Kadarik, Rene Valner ning Siiri Vallner, Indrek Peil; täiendav ost (Muinsuskaitseamaet): Nikolai Serebrjakov, Leonid Tozil, Sergei Sevtsenko, Sulev Roosmaa. 6 illustratsiooni

  11. Mammutraamat viimase viie aasta parimast arhitektuurist / Inga Raukas

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    2004-01-01

    2004. a. Londonis Phaidon Pressilt ilmunud raamatust "The Phaidon Atlas of Contemporary World Architecture", mis sisaldab 75 riigi 1052 väljapaistvamat ehitist aastaist 1998-2003. Valik tehti Deyan Sudjici juhtimisel, Eestist Veljo Kaasik.. Eestit esindavad Indrek Allmanni paariselamu ja Martin Aunini Orro villa Tabasalus, 3+1 arhitektide Villa-V, Indrek Näki "Neiseri" tehas. Leedut esindab ka 3+1 arhitektide Eesti saatkond

  12. 15 aastat ehitamist Eestis / Ado Eigi

    Index Scriptorium Estoniae

    Eigi, Ado, 1938-2008

    2006-01-01

    Eesti arhitektuur viimase 15 aasta jooksul. Loetletud parimad arhitektuuriteosed: Mardi talu Saaremaal (Jüri Okas, 2002); Transgroup Investi büroohoone Tallinnas (Urmas Lõoke, 2005); Ferrumi kaubanduskeskuse hoone Kuressaares (Andres Alver, Tiit Trummal, Tarmo Laht, Indrek Rünkla, Ulla Mets, 2002); KUMU kunstimuuseum (Pekka Vapaavuori, 2005); Lootsi 3a korterelamu Tallinnas (Hanno Grossschmidt, 2005); City Plaza Tallinnas (Andres Alver, Tiit Trummal, Martin Melioranski, Indrek Rünkla, 2005); Okupatsioonide muuseum (Indrek Peil, Siiri Vallner, 2003); Pärnu kesklinna koolide võimla (Katrin Koov, Kaire Nõmm, Heidi Urb, Siiri Vallner, 2005); De la Gardie kaubamaja Tallinnas (Andres Alver, Tiit Trummal, Tarmo Laht, 2000); Lasnamäe spordihoone Tallinnas (Siiri Vallner, Hanno Grossschmidt, Tomomi Hayashi, 2003); TTP büroohoone Tallinnas (Meelis Press, 2005)

  13. Evaluation of a Coaching Experiential Learning Project on OT Student Abilities and Perceptions

    Directory of Open Access Journals (Sweden)

    Erin A. Phillips

    2017-01-01

    Full Text Available Innovative teaching methods to address emerging practice needs are critical components of effective occupational therapy education. Experiential learning strategies can enhance skill development and translation of knowledge into OT clinical practice. In addition, skills such as coaching may provide important links to health promotion practices. Thirty-two occupational therapy students took part in an experiential project to connect occupational engagement and health for a community of older adults. A pretest/posttest design was used to evaluate program outcomes in student perceived abilities, and narrative reflection papers provided postexperience qualitative information. The students improved in all 10 areas of abilities selfassessment with mean total scores from pretest (M = 42 improving significantly at posttest (M = 58. Themes from reflection papers indicated a positive response to experiential learning and a desire for more opportunities to prepare for clinical practice, including the use of interprofessional training. The students improved in their abilities to use coaching and health promotion strategies through the use of experiential learning methods. Outcomes suggest that experiential learning opportunities are an effective way to enhance student competencies in coaching, improve readiness for wellness programming, and increase student confidence in application of skills in future clinical practice.

  14. Caracterización de la comunidad de macroinvertebrados de la Quebrada Paloblanco de la Cuenca del Río Otún (Risaralda, Colombia

    Directory of Open Access Journals (Sweden)

    Eleonora Bernal Pinilla

    2006-07-01

    Full Text Available Se realizó un estudio de las comunidades de macroinvertebrados presentes en la quebrada Paloblanco, ubicada en la cuenca del río Otún (Risaralda, Colombia. Los puntos de muestreo seleccionados corresponden a la cabecera y la zona cercana a la desembocadura en el río Otún, ambos con características geomorfológicas de corrientes de primer orden. En cada punto se colectaron los macroinvertebrados de las unidades funcionales hojarasca, epiliton, musgo y grava, junto con una muestra de deriva y fauna general (sin discriminar unidad funcional. Se encontraron 42 familias de Insecta, además de Acari, Annelida, Crustacea e Hirudinea. Igualmente se encontraron familias de presencia exclusiva en cada punto, mostrando diferencias en la composición de las comunidades. Los índices ecológicos empleados mostraron una mayor diversidad en punto bajo y diferencias entre algunas de las unidades funcionales, relacionados con el medio y los hábitos presentes. Para el análisis se tuvieron en cuenta los conceptos de continuo y zonación de los ríos. A pesar de tener condiciones de primer orden, existen variaciones a pequeña escala entre los puntos de muestreo, que están relacionadas con la intervención antrópica en la zona aledaña a punto bajo.

  15. Eesti arhitektuur trügis maailmakaardile / Tiina Kolk

    Index Scriptorium Estoniae

    Kolk, Tiina

    2004-01-01

    Neli eesti arhitektide projekteeritud hoonet on pääsenud kunstikirjastuse Phaidon raamatusse "The Phaidon Atlas of Contemporary World Architecture": Indrek Allmanni paariselamu Luccas, Martin Aunini eramu Orro Tabasalus, Indrek Näki Neiseri tööstushoone ja büroo 3+1 arhitektide Villa V. 3+1 arhitektid Markus Kaasik, Andres Ojari, Ilmar Valdur ja Inga Raukas esindavad ka Leedumaad Eesti saatkonnahoonega Vilniuses. 4 ill

  16. OT2_smalhotr_3: Herschel Extreme Lensing Line Observations (HELLO)

    Science.gov (United States)

    Malhotra, S.

    2011-09-01

    We request 59.8 hours of Herschel time to observe 20 normal star-forming galaxies in the [CII] 158 micron and [OI] 63 micron lines. These galaxies lie at high redshift (1OT1, 49 high redshift IR luminous galaxies were approved for spectroscopy, but only two so-called normal galaxies were included. This is an imbalance that should be corrected, to balance Herschel's legacy.

  17. Farmakoterapia zaburzeń behawioralnych towarzyszących otępieniu

    Directory of Open Access Journals (Sweden)

    Tomasz Sobów

    2013-12-01

    Full Text Available Farmakoterapia zaburzeń zachowania i objawów neuropsychiatrycznych u chorych otępiałych (behavioural and psychological symptoms of dementia, BPSD była przedmiotem wielu badań klinicznych. Ich wyniki nie pozwalają niestety na sformułowanie prostych zaleceń. Leki przeciwpsychotyczne (zwłaszcza II generacji okazały się względnie skuteczne w zwalczaniu pobudzenia i agresji, ale ich działanie na objawy psychotyczne jest wątpliwe. Poważne obawy dotyczące bezpieczeństwa stosowania leków przeciwpsychotycznych (zwłaszcza ryzyko ostrych zdarzeń sercowo-mózgowych i związanej z nimi śmiertelności w znaczący sposób ograniczają ich wykorzystanie. Leki przeciwdepresyjne, szczególnie z grupy selektywnych inhibitorów zwrotnego wychwytu serotoniny (selective serotonin reuptake inhibitor, SSRI, wykazują podobną skuteczność w zwalczaniu pobudzenia i objawów psychotycznych jak leki przeciwpsychotyczne, co wobec lepszej tolerancji zachęca do ich szerszego stosowania. Inne grupy leków (w tym przeciwdrgawkowe i benzodiazepiny, pomimo teoretycznych przesłanek sugerujących możliwą skuteczność, w randomizowanych badaniach nie zostały ocenione jako wystarczająco efektywne (i bezpieczne, aby rekomendować ich szersze wykorzystanie. Rutynowe stosowanie zasady hierarchicznego postępowania w BPSD (najpierw staranna diagnostyka, w tym wykluczenie majaczenia, następnie interwencje niefarmakologiczne i optymalizacja leczenia inhibitorami cholinesterazy i/lub memantyną, a dopiero w trzeciej kolejności zastosowanie leków psychotropowych pozwala na ograniczenie farmakoterapii w tej szczególnie wrażliwej grupie pacjentów.

  18. Rahvusooperi Estonia teatrihoone publikuruumide restaureerimistöödest / Liivi Künnapu

    Index Scriptorium Estoniae

    Künnapu, Liivi, 1953-

    2006-01-01

    Arhitektuuriajalooline ülevaade. 2005. a. restaureerimistöödest: garderoob-vestibüülist, peatrepist, ringfuajeedest, teatri- ja Valgest saalist, keldrikorruse ruumidest. Muinsuskaitse eritingimused, järelevalve: Liivi Künnapu. Projekteerijad: Peep Jänes, Indrek Suigussaar, AB Kolde Grupp. Sisekujundus: Juta Lember, Aulo Padar. Teostus: Koger ja Partnerid, projektijuht Indrek Võeras. Laemaali (E. Okas, E. Kits, R. Sagrits) restaureerimine, uuringud: KAR-Grupp. Akustik: Linda Madalik. Bibliogr. lk. 25. 8 vaadet

  19. Transcriptional analysis and molecular dynamics simulations reveal the mechanism of toxic metals removal and efflux pumps in Lysinibacillus sphaericus OT4b.31

    KAUST Repository

    Shaw, Dario Rangel

    2017-11-23

    Lysinibacillus sphaericus strain OT4b.31 is a bacterium widely applied in bioremediation processes of hydrocarbon and metal polluted environments. In this study, we identified the molecular mechanism underlying the Pb2+ and Cr6+ resistance. Metal uptake and temporal transcription patterns of metal resistance operons were evaluated using reverse-transcribed quantitative PCR amplification. The function of the resistance determinants was studied applying docking and in silico mutagenesis methods. The results revealed that the adaptation of Lysinibacillus sphaericus OT4b.31 to elevated levels of lead and chromium involves the pbr and chr operons which comprise a transcriptional regulatory component (pbrR and chrB) and efflux ATPases (pbrA and chrA) to expel ions from the cytoplasm. Expression of metal resistance genes was constitutive and specifically inducible to the exposure of Pb2+ and Cr6+. The simultaneous presence of cations didn\\'t affect the bioaccumulation of metals, evidencing the multimetal resistance of L. sphaericus. Docking analysis revealed the key metal-protein interactions and the conformational changes after metal or ATP binding. Results showed that residues with aromatic rings or imidazole in the catalytic domain are crucial for metal binding and achievement of the function. To our knowledge, this is the first report of a specific mechanism for lead and chromium resistance in Lysinibacillus genus. From the findings of this study, it is possible to suggest the bacterium as a suitable candidate for rapid toxic metals bioremediation processes.

  20. Effect of Ozone Therapy (OT on Healing of Colonic Anastomosis in a Rat Model of Peritonitis

    Directory of Open Access Journals (Sweden)

    Başak Erginel

    2014-09-01

    Full Text Available Background: Ozone is a three-oxygen molecule (O3. Ozone therapy (OT is systematically effective when pathological inflammatory and immunologic processes are activated. Among of these conditions are wound healing, macular degeneration related to aging, and conditions that are ischemic or infectious. Aims: The aim of this study was to determine the effects of OT on wound healing of intestinal anastomosis in the presence of peritonitis in a rat model. Study Design: Animal experimentation. Methods: A total of 40 Wistar albino rats were randomized into four groups (n=10 including: sham (S, peritonitis (P, ozone 0 (O0, and ozone 24 (O24. In group S, only cecal dissection was carried out. The S group had only a cecal dissection and intestinal anastomosis performed, but no peritonitis. In all other groups, cecal ligation and puncture (CLP followed the cecal dissection to induce bacterial peritonitis. 24 h after puncture, a cecal resection and ileocolic anastomosis were performed. In group P, 24 h after CLP, a cecal resection and ileocolic anastomosis were performed and no ozone was administered. In group O0, immediately after the anastomosis, and in group O24, starting 24 hours after the anastomosis, an intraperitoneal 1 mg/kg/day ozone administration was applied for seven days. On the seventh day the animals were sacrificed, the anastomotic bursting pressures (BP and the hydroxyproline values of the anastomotic tissues were measured, and histopathologic examination of the anastomotic segment was carried out. Results: The highest BP was in group S, with 211±23.13 mmHg. The mean BP of group P was 141±56.25 mmHg, which was significantly lower than in the other two peritonitis groups that received ozone therapy, group O0 and O24, where it was 192±22 and 166±45 mmHg, respectively (p0.05. Histopathologic analyses of the anastomotic segments determined there was significantly more oedema and necrosis in the control group rats, and collagen deposition in

  1. DNA methylation patterns of imprinting centers for H19, SNRPN, and KCNQ1OT1 in single-cell clones of human amniotic fluid mesenchymal stem cell

    Directory of Open Access Journals (Sweden)

    Hsiu-Huei Peng

    2012-09-01

    Conclusion: In conclusion, human amniotic fluid mesenchymal stem cells contain a unique epigenetic signature during in vitro cell culture. H19 and KCNQ1OT1 possessed a substantial degree of hypermethylation status, and variable DNA methylation patterns of SNRPN was observed during in vitro cell culture of human amniotic fluid mesenchymal stem cells. Our results urge further understanding of epigenetic status of human amniotic fluid mesenchymal stem cells before it is applied in cell replacement therapy.

  2. MULTISEASONAL TREE CROWN STRUCTURE MAPPING WITH POINT CLOUDS FROM OTS QUADROCOPTER SYSTEMS

    Directory of Open Access Journals (Sweden)

    S. Hese

    2017-08-01

    Full Text Available OTF (Off The Shelf quadro copter systems provide a cost effective (below 2000 Euro, flexible and mobile platform for high resolution point cloud mapping. Various studies showed the full potential of these small and flexible platforms. Especially in very tight and complex 3D environments the automatic obstacle avoidance, low copter weight, long flight times and precise maneuvering are important advantages of these small OTS systems in comparison with larger octocopter systems. This study examines the potential of the DJI Phantom 4 pro series and the Phantom 3A series for within-stand and forest tree crown 3D point cloud mapping using both within stand oblique imaging in different altitude levels and data captured from a nadir perspective. On a test site in Brandenburg/Germany a beach crown was selected and measured with 3 different altitude levels in Point Of Interest (POI mode with oblique data capturing and deriving one nadir mosaic created with 85/85 % overlap using Drone Deploy automatic mapping software. Three different flight campaigns were performed, one in September 2016 (leaf-on, one in March 2017 (leaf-off and one in May 2017 (leaf-on to derive point clouds from different crown structure and phenological situations – covering the leaf-on and leafoff status of the tree crown. After height correction, the point clouds where used with GPS geo referencing to calculate voxel based densities on 50 × 10 × 10 cm voxel definitions using a topological network of chessboard image objects in 0,5 m height steps in an object based image processing environment. Comparison between leaf-off and leaf-on status was done on volume pixel definitions comparing the attributed point densities per volume and plotting the resulting values as a function of distance to the crown center. In the leaf-off status SFM (structure from motion algorithms clearly identified the central stem and also secondary branch systems. While the penetration into the

  3. Multiseasonal Tree Crown Structure Mapping with Point Clouds from OTS Quadrocopter Systems

    Science.gov (United States)

    Hese, S.; Behrendt, F.

    2017-08-01

    OTF (Off The Shelf) quadro copter systems provide a cost effective (below 2000 Euro), flexible and mobile platform for high resolution point cloud mapping. Various studies showed the full potential of these small and flexible platforms. Especially in very tight and complex 3D environments the automatic obstacle avoidance, low copter weight, long flight times and precise maneuvering are important advantages of these small OTS systems in comparison with larger octocopter systems. This study examines the potential of the DJI Phantom 4 pro series and the Phantom 3A series for within-stand and forest tree crown 3D point cloud mapping using both within stand oblique imaging in different altitude levels and data captured from a nadir perspective. On a test site in Brandenburg/Germany a beach crown was selected and measured with 3 different altitude levels in Point Of Interest (POI) mode with oblique data capturing and deriving one nadir mosaic created with 85/85 % overlap using Drone Deploy automatic mapping software. Three different flight campaigns were performed, one in September 2016 (leaf-on), one in March 2017 (leaf-off) and one in May 2017 (leaf-on) to derive point clouds from different crown structure and phenological situations - covering the leaf-on and leafoff status of the tree crown. After height correction, the point clouds where used with GPS geo referencing to calculate voxel based densities on 50 × 10 × 10 cm voxel definitions using a topological network of chessboard image objects in 0,5 m height steps in an object based image processing environment. Comparison between leaf-off and leaf-on status was done on volume pixel definitions comparing the attributed point densities per volume and plotting the resulting values as a function of distance to the crown center. In the leaf-off status SFM (structure from motion) algorithms clearly identified the central stem and also secondary branch systems. While the penetration into the crown

  4. Teatri aastaauhindade nominendid 2006. aasta loomingu eest

    Index Scriptorium Estoniae

    2007-01-01

    Nimekiri nominentidest teatri aastaauhinnale sõna-, muusika-, balleti-, tantsulavastuste ja teatri tehnilise töötaja auhinna kategoorias. Kunstnikuauhind: Vladimir Anshon - "Nii see on (kui teile nii näib)" (Tallinna Linnateater) ja "Valged ööd" (Theatrum), Andris Freibergs - "Karin. Indrek. Tõde ja õigus. 4." (Tallinna Linnateater), Kristine Pasternaka - kostüümid lavastustele "Karin. Indrek. Tõde ja õigus. 4." ja "Nii see on (kui teile nii näib" (Tallinna Linnateater), Ene-Liis Semper - "Kuningas Ubu" (NO99), Ervin Õunapuu -"Sada aastat..." (Vanemuine).

  5. Pressure effects on enzyme reactions in mainly organic media: alpha-chymotrypsin in reversed micelles of Aerosol OT in octane.

    Science.gov (United States)

    Mozhaev, V V; Bec, N; Balny, C

    1994-08-01

    Biocatalytic transformations in reversed micelles formed by anionic surfactant Aerosol OT in octane have been studied at high pressures by an example of alpha-chymotrypsin-catalyzed hydrolysis of N-carbobenzoxy-L-tyrosine p-nitrophenyl ester and N-succinyl-L-phenylalanine p-nitroanilide. For the first time it has been found that the enzyme retains high activity in these water-in-oil microemulsions up to a pressure of 2 kbar. The value of the activation volume (delta V*) for the enzyme reactions shows a dependence on the water content in the system. When the size of the micellar aqueous inner cavity (as evaluated at 1 atm) approaches the molecular size of alpha-chymotrypsin, delta V* becomes significantly different from the value in aqueous solution and in the micelles with a larger size. Possibilities of regulating the enzyme activity by pressure in systems with a low content of water are discussed.

  6. Dinámica de construcción territorial en los asentamientos del río Otún en Pereira (1950- 2000: fenomenología a la territorialidad del sujeto habitante

    Directory of Open Access Journals (Sweden)

    Julio César Murillo García

    2016-06-01

    Full Text Available El presente artículo surge como resultado del análisis- interpretación a la dinámica territorial en los asentamientos informales ubicados sobre las márgenes del río Otún a su paso por la comuna Otún en la ciudad de Pereira, desde dos momentos nodales de su construcción: momento fundacional (1950 y momento de toma y apropiación de predios (2000. Como metodología se asume la fenomenología a la territorialidad cotidiana del habitante, explícitamente desde dos variables: contexto socioeconómico y vínculos territoriales. A partir de allí se consolidaron universos de análisis e interpretación sobre la territorialidad del sujeto que dan cuenta de fricciones y/o conflictos espaciales con respecto a la política pública territorial del municipio de Pereira, en medio de la ejecución de programas y proyectos de gestión y planificación territorial con un denotado carácter hegemónico. Con ello se despeja un panorama crítico reflexivo alrededor de la implementación de estas políticas y al desarrollo sostenible territorial.

  7. CD80 and CD86 Costimulatory Molecules Differentially Regulate OT-II CD4+ T Lymphocyte Proliferation and Cytokine Response in Cocultures with Antigen-Presenting Cells Derived from Pregnant and Pseudopregnant Mice

    Directory of Open Access Journals (Sweden)

    Tomasz Maj

    2014-01-01

    Full Text Available Immune phenomena during the preimplantation period of pregnancy are poorly understood. The aim of our study was to assess the capacity for antigen presentation of splenic antigen-presenting cells (APCs derived from pregnant and pseudopregnant mice in in vitro conditions. Therefore, sorted CD11c+ dendritic cells and macrophages F4/80+ and CD11b+ presenting ovalbumin (OVA were cocultured with CD4+ T cells derived from OT-II mice’s (C57BL6/J-Tg(TcraTcrb1100Mjb/J spleen. After 132 hours of cell culture, proliferation of lymphocytes (ELISA-BrdU, activation of these cells (flow cytometry, cytokine profile (ELISA, and influence of costimulatory molecules blocking on these parameters were measured. We did not detect any differences in regulation of Th1/Th2 cytokine balance. CD86 seems to be the main costimulatory molecule involved in the proliferation response but CD80 is the main costimulatory molecule influencing cytokine secretion in pregnant mice. In conclusion, this study showed that CD80 and CD86 costimulatory molecules regulate OT-II CD4+ T lymphocyte proliferation and cytokine response in cocultures with antigen-presenting cells derived from pregnant and pseudopregnant mice. The implications of these changes still remain unclear.

  8. Secondary Metabolite Profiling of Species of the Genus Usnea by UHPLC-ESI-OT-MS-MS

    Directory of Open Access Journals (Sweden)

    Francisco Salgado

    2017-12-01

    Full Text Available Lichens are symbiotic associations of fungi with microalgae and/or cyanobacteria, which are considered among the slowest growing organisms, with strong tolerance to adverse environmental conditions. There are about 400 genera and 1600 species of lichens and those belonging to the Usnea genus comprise about 360 of these species. Usnea lichens have been used since ancient times as dyes, cosmetics, preservatives, deodorants and folk medicines. The phytochemistry of the Usnea genus includes more than 60 compounds which belong to the following classes: depsides, depsidones, depsones, lactones, quinones, phenolics, polysaccharides, fatty acids and dibenzofurans. Due to scarce knowledge of metabolomic profiles of Usnea species (U. barbata, U. antarctica, U. rubicunda and U. subfloridana, a study based on UHPLC-ESI-OT-MS-MS was performed for a comprehensive characterization of their secondary metabolites. From the methanolic extracts of these species a total of 73 metabolites were identified for the first time using this hyphenated technique, including 34 compounds in U. barbata, 21 in U. antarctica, 38 in U. rubicunda and 37 in U. subfloridana. Besides, a total of 13 metabolites were not identified and reported so far, and could be new according to our data analysis. This study showed that this hyphenated technique is rapid, effective and accurate for phytochemical identification of lichen metabolites and the data collected could be useful for chemotaxonomic studies.

  9. Vy jste mi z té otázky utekl (analýza jednoho způsobu vymáhání odpovědi s využitím korpusových dokladů)

    Czech Academy of Sciences Publication Activity Database

    Jílková, Lucie

    2015-01-01

    Roč. 97, č. 1 (2015), s. 31-11 ISSN 0008-7386 R&D Projects: GA ČR GAP406/12/1829 Institutional support: RVO:68378092 Keywords : the expression vy mi utíkáte z otázky * the SYN2013PUB corpus * the DIALOG corpus, metaphor Subject RIV: AI - Linguistics

  10. Keskkonnaministeerium tutvustas omavalitsustele kahte tõukefondi / Elina Kononenko

    Index Scriptorium Estoniae

    Kononenko, Elina, 1981-

    2004-01-01

    Keskkonnaministeeriumi veeosakonna juhataja Indrek Tamberg tutvustas Võrumaa omavalitsustele ühtekuuluvusfondi (CF) ja regionaalarengufondi (RDF), kust omavalitsused saavad taotleda raha keskkonna ja infrastruktuuri parandamiseks

  11. Characterization of the archaeal ribonuclease P proteins from Pyrococcus horikoshii OT3.

    Science.gov (United States)

    Terada, Atsushi; Honda, Takashi; Fukuhara, Hideo; Hada, Kazumasa; Kimura, Makoto

    2006-08-01

    Ribonuclease P (RNase P) is a ribonucleoprotein complex involved in the processing of the 5'-leader sequence of precursor tRNA (pre-tRNA). Our earlier study revealed that RNase P RNA (pRNA) and five proteins (PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30) in the hyperthermophilic archaeon Pyrococcus horikoshii OT3 reconstituted RNase P activity that exhibits enzymatic properties like those of the authentic enzyme. In present study, we investigated involvement of the individual proteins in RNase P activity. Two particles (R-3Ps), in which pRNA was mixed with three proteins, PhoPop5, PhoRpp30, and PhoRpp38 or PhoPop5, PhoRpp30, and PhoRpp21 showed a detectable RNase P activity, and five reconstituted particles (R-4Ps) composed of pRNA and four proteins exhibited RNase P activity, albeit at reduced level compared to that of the reconstituted particle (R-5P) composed of pRNA and five proteins. Time-course analysis of the RNase P activities of R-4Ps indicated that the R-4Ps lacking PhoPop5, PhoRpp21, or PhoRpp30 had virtually reduced activity, while omission of PhoRpp29 or PhoRpp38 had a slight effect on the activity. The results indicate that the proteins contribute to RNase P activity in order of PhoPop5 > PhoRpp30 > PhoRpp21 > PhoRpp29 > PhoRpp38. It was further found that R-4Ps showed a characteristic Mg2+ ion dependency approximately identical to that of R-5P. However, R-4Ps had optimum temperature of around at 55 degrees C which is lower than 70 degrees C for R-5P. Together, it is suggested that the P. horikoshii RNase P proteins are predominantly involved in optimization of the pRNA conformation, though they are individually dispensable for RNase P activity in vitro.

  12. Kontseptualism provintsimuuseumis / Indrek Grigor

    Index Scriptorium Estoniae

    Grigor, Indrek

    2011-01-01

    Näitus "Continuum_ Kunst kui taju. Ruum kui protsess" Tallinna Kunstihoones 2. oktoobrini 2011, kuraator Maria Arusoo. Pikemalt Martin Creedi, Spencer Finchi, Olafur Eliassoni, Toomas Thetloffi, Kiwa, Daniel Kemeny ja Maria Arusoo, John Woodi ja Paul Harrissoni töödest

  13. Konfiskeerimine haldussunnivahendina / Indrek Koolmeister

    Index Scriptorium Estoniae

    Koolmeister, Indrek, 1949-

    1999-01-01

    Konfiskeerimise olemusest ja objektist, selle kohaldamisest juriidiliste isikute suhtes, konfiskeerimise ulatusest ja täitemenetlusest ning kolmandate isikute õigustest seoses asja konfiskeerimisega

  14. Vesi peale! Ikka ja jälle Tallinna sadamaala kujundamisest / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2007-01-01

    Tallinna sadamaala erinevatest planeeringutest ning arhitektuurikonkurssidest (Irina Raud, Veronika Valk, Villem Tomiste, Jan Verwijnen, Indrek Pottisep, Lembit Tork, Erik Konze, Taylor&Chapman). Näiteid Euroopast

  15. Liberalistlik sissejuhatus poliitilisse filosoofiasse / Tanel Vallimäe, Peeter Selg

    Index Scriptorium Estoniae

    Vallimäe, Tanel, 1975-

    2008-01-01

    Vastukaja arvustusele: Reiland, Indrek. Normatiivse poliitikafilosoofia peateemad (Rets. rmt.: Wolff, Jonathan. Sissejuhatus poliitikafilosoofiasse / tlk. Tiiu Hallap. Tartu, 2005). Akadeemia, 2008, nr. 4, lk. 880-883

  16. The Center Party - political games like never before / Kristiina Raudsepp

    Index Scriptorium Estoniae

    Raudsepp, Karoliina

    2011-01-01

    Keskerakonna meediakajastusi tõstnud ettevõtmised nagu Indrek Tarandi seadmine teiseks presidendikandidaadiks ja Jüri Ratase osalemine Keskerakonna juhi valimistel tõestavad Edgar Savisaare tugevust poliitmaastikul

  17. Neumann aitab rahvuskaaslased maailma turule / Kati Murutar

    Index Scriptorium Estoniae

    Murutar, Kati, 1967-

    2009-01-01

    Norras elava rahvusvahelise äri spetsialisti Indrek Michael Neumanni firma Progate Trade International Business Consulting and Solution annab Eesti ettevõtjatele nõuandeid rahvusvahelisele turule sisenemiseks

  18. Kuidas kaasajal mõtestada rahvuslust? / ref. Urmi Reinde

    Index Scriptorium Estoniae

    2008-01-01

    Keskerakonna noortekogu korraldatud konverentsil "Kuidas kaasajal mõtestada rahvuslust?" peetud ettekannete refereeringud: Edgar Savisaar, Leif Kalev, Ahto Lobjakas, Indrek Neivelt, Iris Pettai, Andrei Hvostov, Rein Ruutsoo

  19. Eesti Arhitektide Liidu aastapreemia 2015 = The annual prize of 2015 of the Union of Estonian Architects / Rainer Mahlamäki

    Index Scriptorium Estoniae

    Mahlamäki, Rainer

    2015-01-01

    Soome arhitekti Rainer Mahlamäki mõtteid Eesti kaasaegsest arhitektuurist, tema ringsõidust Tallinnasse, Kuressaarde, Pärnusse ja Tartusse. Eesti Arhitektide Liidu aastapreemia 2015 äramärkimine: villa Pärnus Lõuna 2a restaureerimine (arhitekt Jaak Huimerind, sisearhitekt Mari Kurismaa). Eesti Arhitektide Liidu aastapreemia 2015 kandidaadid: elu- ja ärihoone Tallinnas Kentmanni 6 (arhitekt Indrek Allmann); büroohoone Tallinnas Sõpruse pst 157 (arhitekt Indrek Suigusaar); Tallinna Tehnikaülikooli Kuressaare kolledži väikelaevaehituse kompetentsikeskuse katsebasseini ja laboratooriumite hoone Kuressaares Tallinna 19 (arhitektid Kalle Komissarov, Aet Ader, Mari Hunt, Kadri Klementi, Lembit-Kaur Stöör); White Beach golfi klubihoone Valgerannas Pärnumaal (arhitektid Jaan Port, Markus Nimik, Katrin Kaevats, Neeme Tiimus)

  20. Investigación y práctica urbanística desde la Escuela de Arquitectura de Madrid : 20 años de actividad del Instituto Juan de Herrera (SPyOT, 1977-1997

    Directory of Open Access Journals (Sweden)

    Ramón López de Lucio

    1997-11-01

    For two decades now, research and urban practice at Escuela Técnica Superior de Arquitectura de Madrid has notably come apart from dominant planning ideology, in which "urban project" has been considered from a quite reductionist approach, so embedded in the paradigmatic tautology of "urban urbanism", as the only way of working and teaching. In 1977 a group of professors of what latter became the Departamento de Urbanística y Ordenación del Territorio de la E.T.S. de Arquitectura de Madrid decided to organize themselves as a working group with the objective of developing research projects and eventually professional work of particular interest in the fields of city and regional planning. Under the name of Seminario de Planeamiento y Ordenación del Territorio (SPyOT this group started a series of research projects focusing initially in Madrid -as central object of study and laboratory of new planning initiatives- and in the comprehensive plans of the main Spanish cities. After 20 years of uninterrupted activity the initial group has grown and consolidated, and its fields of activity have expanded. More than one hundred projects coordinated by two dozens of professors have been completed in which about 200 hundred students have cooperated. A permanent platform for research within the university has developed and an alternative for professional work for full-time professors has been created, following the guidelines of the University Reform Law (LRU. A considerable number of outstanding students have started careers in the planning field, both in the public and private sectors. After 20 years it can be said that the always difficult relationship between academia and the professional world, both for students and professors, has been facilitated by the existence of the SPyOT. Today the SPyOT has become the Sección de Urbanismo del Instituto Juan de Herrera. This publication includes, after some introductory remarks by the Directors of the Planning Department of the

  1. Põhja-Eesti Regionaalhaigla X-korpus = North-Estonian Regional Hospital X-wing / Mari Kurismaa ; intervjueerinud Margit Mutso

    Index Scriptorium Estoniae

    Kurismaa, Mari, 1956-

    2011-01-01

    Tallinnas Sütiste tee 19 asuva haigla juurdeehitise sisekujundusest. Sisearhitekt Mari Kurismaa (Stuudio Kurismaa OÜ). Arhitektid Indrek Suigusaar, Vivian Oruvee (AB Pluss OÜ). Infograafika autor Mari Kaljuste

  2. Election rhetoric heats up

    Index Scriptorium Estoniae

    2011-01-01

    Presidendivalimiste debatil oli kõne all ka Eesti haldusreform. President Toomas Hendrik Ilves kritiseeris Tallinna juhtimist. Presidendikandidaat Indrek Tarand lubas kohalike omavalitsuste ebaõiglase finantsjuhtimisega võidelda

  3. Hingekeeled ajaloo kuumas tolmus / Jan Kaus

    Index Scriptorium Estoniae

    Kaus, Jan, 1971-

    2011-01-01

    Arvustus: Hargla, Indrek. Apteeker Melchior ja timuka tütar : kriminaalromaan vanast Tallinnast. Tallinn : Varrak, 2011 ja Aleksejev, Tiit. Kindel linn : lugu Esimesest ristisõjast. Tallinn : Varrak, 2011

  4. Тартуский Колледж Здравоохранения = Tartu Healthcare College / Мария Фадеева

    Index Scriptorium Estoniae

    Фадеева, Мария

    2014-01-01

    Tartu Tervishoiu Kõrgkooli uus hoone. Arhitektid Siiri Vallner, Indrek Peil, Johannes Feld, Andro Mänd, Sten-Mark Mändmaa, Ragnar Põllukivi (Kavakava). Sisearhitekt Tarmo Piirmets (PINK). Valmimisaasta: 2011

  5. Estonia - üks tõeline eestimaine spaa / Dagmar Reinolt

    Index Scriptorium Estoniae

    Reinolt, Dagmar

    2015-01-01

    Heaoluspaa võtmes renoveeritud Estonia Spa Hotelsi ühest kompleksist. Rekonstrueerimisprojekti arhitektid: Raivo Kotov, Indrek Mikk. Rekonstrueerimisprojekti sisearhitektid: Raili Paling, Liis Lindvere, Kadri Kaldam, Kärt Loopalu. Valmimisaasta: 2015

  6. Ulmekaravan liigub / Veiko Belials

    Index Scriptorium Estoniae

    Belials, Veiko, 1966-

    2001-01-01

    Arvustus: Hargla, Indrek. Pan Grpowski üheksa juhtumit. Tallinn : Kuldsulg, 2001 ; Berg, Lew R. Tempel selvas. Tallinn : Salasõna, 2001 ; Veskimees, Siim. Operatsioon "Ogaline Päike. Tallinn : Fantaasia, 2001

  7. Seltskond / Annika Haas

    Index Scriptorium Estoniae

    Haas, Annika

    2009-01-01

    Eesti Posti peakontori hoovis esitleti Indrek Kaingi kujundatud rahvusmustriga tenniseid. Esimesed eksklusiivsed kaks paari MULK-kirjaga papusid kingiti president Toomas Hendrik Ilvesele ning ettevõtte Skype presidendile Josh Silvermanile

  8. Kindergarten Lotte, Tartu, Estland / Annette Weckesser

    Index Scriptorium Estoniae

    Weckesser, Annette

    2009-01-01

    Lotte lasteaiast Tartus. Projekteeris arhitektuuribüroo Kavakava (Siiri Vallner, Indrek Peil), interjööri kujundas Laika, Belka & Strelka (Krista Lepland, Malle Jürgenson, Sirli Ehari, Tea Tammelaan)

  9. Kindergarten, Tartu / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2008-01-01

    Lotte lasteaiast Tartus. Arhitektid Siiri Vallner, Indrek Peil ja Sten-Mark Mändmaa arhitektuuribüroost Kavakava. Sisekujundus Sirli Eharilt arhitektuuribüroost Laika, Belka & Strelka. 7 vaadet, joonised

  10. Sajandilõpu noori autoreid : Kruoganist Urduni / Piret Viires

    Index Scriptorium Estoniae

    Viires, Piret, 1963-

    1999-01-01

    Arvustus: Kruogan / koost. Hedda Maurer. Tallinn : Vares, 1998 ; Hea raamat / NAK ; toim. Indrek Särg. Tartu : Eesti Kostabi Selts, 1998 ; Harakkiri. Tallinn : Erakkond, 1999 ; Urdu : [kirjanduslik kogumik]. Rewal, 1999

  11. Suvelavastus lastele

    Index Scriptorium Estoniae

    1999-01-01

    5. juunil Linnateatri hoovil asuvas lavaaugus "Prints ja kerjus", Mark Twaini romaani järgi kirjutanud Peeter Sauter, lavastaja Jaanus Rohumaa, kujundaja Mae Kivilo, osades Indrek Sammul, Tõnno Linnas

  12. Peeter Sauter kirjutas oma "Printsi ja kerjuse" / Peeter Sauter ; interv. Margus Kasterpalu

    Index Scriptorium Estoniae

    Sauter, Peeter, 1962-

    1999-01-01

    Vabaõhuetendus "Prints ja kerjus" Linnateatri lavaaugus, Mark Twaini romaani ainetel kirjutanud Peeter Sauter, lavastaja Jaanus Rohumaa, kunstnik Mae Kivilo, helilooja Margo Kõlar, osades Indrek Sammul ja Tõnno Linnas

  13. Nõmme ja Kristiine piirikünkale Järvel kerkib sihvakas torn / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2005-01-01

    Järve keskuse naabrusesse ehitatavast 15-korruselisest büroohoonest, Böckleri majast. Autorid Studio Paralleeli arhitektid Jaak Huimerind ja Indrek Saarepera. Lisaks "Kõrghoonete katusevaated võiksid olla avalikud"

  14. Võiduromaan elustab töölisliikumise idee / Ilona Martson

    Index Scriptorium Estoniae

    Martson, Ilona, 1970-

    2001-01-01

    I koht (Aarne Ruben ""Volta" annab kaeblikku vilet"); II koht (Leo Kunnas "Sõdurjumala teener"); III koht (Maimu Veske "Continental" ja Lehte Hainsalu "Kellakuuljad"); Ulmekirjanduse eripreemia Varrakult (Indrek Hargla "Baiita needus")

  15. Romaanivõistluse võitsid uued sõnameistrid / Piret Viires

    Index Scriptorium Estoniae

    Viires, Piret, 1963-

    2001-01-01

    I koht (Aarne Ruben ""Volta" annab kaeblikku vilet"); II koht (Leo Kunnas "Sõdurjumala teener"); III koht (Maimu Veske "Continental" ja Lehte Hainsalu "Kellakuuljad"); Ulmekirjanduse eripreemia Varrakult (Indrek Hargla "Baiita needus")

  16. Esikromaan tõi filoloogitudengile võidu : Aarne Rubeni võiduromaanist ""Volta" annab kaeblikku vilet" huvitus esimesena kirjastus Tänapäev / Neeme Korv, Peeter Selg

    Index Scriptorium Estoniae

    Korv, Neeme, 1974-

    2001-01-01

    I koht (Aarne Ruben ""Volta" annab kaeblikku vilet"); II koht (Leo Kunnas "Sõdurjumala teener"); III koht (Maimu Veske "Continental" ja Lehte Hainsalu "Kellakuuljad"); Ulmekirjanduse eripreemia Varrakult (Indrek Hargla "Baiita needus")

  17. Apteeginaps ajaloomälu turgutuseks / Aet Varik

    Index Scriptorium Estoniae

    Varik, Aet

    2011-01-01

    Arvustus: Hargla, Indrek. Apteeker Melchior ja Oleviste mõistatus. Tallinn : Varrak, 2010 ; Apteeker Melchior ja Rataskaevu viirastus. Tallinn : Varrak, 2010 ; Apteeker Melchior ja timuka tütar. Tallinn : Varrak, 2011

  18. Keskerakonna presidendikandidaat loobus Tallinna TV vastaste allkirjade viimisest linnavalitsusse

    Index Scriptorium Estoniae

    2011-01-01

    Presidendikandidaat Indrek Tarand pidi andma Tallinna linnavalitsusele üle Tallinna TV vastased allkirjad. Viimasel hetkel otsustas I. Tarand ümber ja allkirjad viisid linnavalitsusse MTÜ Kodaniku Hääl esindajad

  19. Wannabe - Ameerika ja Postkontor 2 / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2008-01-01

    Uued hotellid Tallinna kesklinnas: Kaksiktornid (arhitektuuribüroo Nord Projekt, Meeli Truu, sisekujundaja Meelis Press); Forumi hotell (arhitektuuribüroo Pluss, Indrek Allmann, sisekujundajad Kaire Kemp-Tishler ja Ea Andla)

  20. Mehed unustatud armeest / Margit-Mariann Koppel

    Index Scriptorium Estoniae

    Koppel, Margit-Mariann, 1971-

    2006-01-01

    Dokumentaalfilm "Mehed unustatud armeest" : autor Indrek Treufeldt : režissöör Kalle Käesel : produtsent Renita Timak : ETV ja Osakond OÜ 2006. Film esilinastus Tallinna kinos Sõprus 21. novembril

  1. Summer võistleb jalgpalli MMil

    Index Scriptorium Estoniae

    2007-01-01

    Rocklaulja Indrek Raadik (Summer) on sooloprojektiga tuuril koos bändidega Traffic ja Mees, juuni lõpul aga koos ansamblitega esindamas Eestit Sotšis toimuval artistide esimesel maailmameistrivõistlusel jalgpallis

  2. Pronksiööl küpsenud valus tõde / Gerda Kordemets ; intervjueeris Jüri Aarma

    Index Scriptorium Estoniae

    Kordemets, Gerda, 1960-

    2009-01-01

    ETV lavastuslike saadete toimetuse juhataja meenutab Tallinna Linnateatri lavastuse "Karin ja Indrek. Tõde ja õigus" Eesti Televisioonile lindistamist aprillis 2007. Lavastaja Elmo Nüganen, aluseks Tammsaare "Tõe ja õiguse" IV osa

  3. Meltsiveski Konsumist saab korteritega supermarket / Nils Niitra

    Index Scriptorium Estoniae

    Niitra, Nils, 1975-

    2005-01-01

    Meltsiveski Konsumi kõrvale ehitatakse uus hoone, kus saab olema 30 korterit ja supermarket ning viimase katusel mängu- ja puhkeala. Juurdeehituse projekteeris arhitektuuribüroo Pluss arhitekt Indrek Allmann

  4. Vene elu hõng Pilistvere rehealuses / Margot Visnap

    Index Scriptorium Estoniae

    Visnap, Margot, 1959-

    2008-01-01

    Pilistvere rehehoones etendunud Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse tõi välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas Indrek Saar

  5. Jaanus Rohumaa suur suvetükk (hingelt) lastele / Rünno Saaremäe

    Index Scriptorium Estoniae

    Saaremäe, Rünno

    1999-01-01

    Tallinna Linnateatris Mark Twaini - Peeter Sauteri "Prints ja kerjus", lavastaja Jaanus Rohumaa, helilooja Marko Kõlar, kunstnik Mae Kivilo, peaosades Indrek Sammul ja Tõnno Linnas.Ka kolm vastust Lavastajalt, Printsilt ja Kerjuselt

  6. Karulaugu lasteaed-algkool = Karulaugu preschool and elementary school / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2009-01-01

    2009. a. Haabneemes Randvere tee 18 valminud Karulaugu lasteaed-algkoolist, mille arhitektid on Emil Urbel ja Indrek Erm, projekteerija AB Emil Urbel, sisekujundajad Taso Mähar ja Ines Haak. Projekt 2007

  7. V zashtshitu zdanija narvskoi Birzhi / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2006-01-01

    Eesti Muinsuskaitse Seltsi juhatuse avaldus seoses Tartu Ülikooli Narva kolledzhi projektiga. Sisaldab retsensiooni projektile "Vihm" (autorid Katrin Koov, Indrek Peil, Siiri Vallner), mis on inspireeritud inglise skulptori Rachel Whitereadi loomingust

  8. Любимцы любимчиков / Сергей Трофимов

    Index Scriptorium Estoniae

    Трофимов, Сергей

    2009-01-01

    Fotograaf Indrek Galetini heategevuslik fotonäitus "Amour - Lemmikloomade eri" Rotermanni Aatriumis Tallinnas. Pildistatud on Eesti tuntud inimesi alasti koos lemmikloomadega. Oksjoni müügitulu läheb kodutute loomade heaks

  9. Põhja-Eesti Regionaalhaigla uus korpus = New Block of the North Estonia Mrdical Centre

    Index Scriptorium Estoniae

    2010-01-01

    Tallinnas Sütiste tee 19 asuva haigla uue korpuse sisekujundusest. Sisearhitekt Mari Kurismaa, tema tähtsamate tööde loetelu. Haigla arhitektid Indrek Suigusaar ja Vivian Oruvee. Infograafika: Mari Kaljuste

  10. Autopsia : [arvustatakse eelmises Marduses ilmunud originaaljutte ja tõlkeid] / Karen Orlau

    Index Scriptorium Estoniae

    Orlau, Karen, pseud., 1975-

    2000-01-01

    Arvustatavad jutud: Smith, Clark Ashton. Öised koletised; Kalevipoeg, pseud. Purpurvalgus; Brown, Molly. Valel ajal; Belials, Veiko. Kunagi. Kuskil. Eikuskil; Lindsay, David. Swaylone'i saar; Hargla, Indrek. Obernoni apokrüüf

  11. Nash sovremennik Tammsaare / Elmo Nüganen ; interv. Nikolai Hrustaljov

    Index Scriptorium Estoniae

    Nüganen, Elmo, 1962-

    2006-01-01

    Tallinna Linnateatris 12. märtsil esietendunud Elmo Nüganeni Tammsaare-lavastusest, mis põhineb "Tõe ja õiguse" neljandal osal. Dramatiseeringu on teinud Elmo Nüganen, peaosades Indrek Sammul ja Hele Kõre

  12. Eesti CRM-lahenduste kasv edestab kasvu maailmas kordades / Martin Goroshko

    Index Scriptorium Estoniae

    Goroshko, Martin

    2005-01-01

    Kliendihaldus- ehk CRM-lahendused, mis aitavad ettevõtetel kliendisuhteid juhtida ja äriprotsesse efektiivsemaks muuta, on saamas populaarseks nii mujal maailmas kui ka Eestis. Diagramm: CRM-i pakkuvate firmade turuosad. Kommenteerib Indrek Saul

  13. Kas Kruuda võib Kalevi müüa? / Mirko Ojakivi, Andres Reimer

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2010-01-01

    Kalevi kommivabriku aktsiad on arestitud, Alta Capitali juhi Indrek Rahumaa hinnangul on praeguse seisuga kommivabriku müümine võimatu. Skandinaavia korporatsioonist Orkla, mis aktsiate aresti alt vabastamise korral saab Kalevi omanikuks

  14. Juhtumikorralduse põhimõtte rakendamisest kohalikus omavalitsuses / Karin Hanga

    Index Scriptorium Estoniae

    Hanga, Karin

    2005-01-01

    27.-28. juunil 2005. a. Pedasel toimunud kohalike omavalitsuste sotsiaal- ja lastekaitsetöötajate suvepäevadel arutluse all olnud juhtumikorralduse probleemidest. Lisatud juhtumi lahendamise skeem. Kommenteerivad: Merle Linno ja Indrek Rohtla

  15. Ilves secures vote to continue in post / Karoliina Raudsepp

    Index Scriptorium Estoniae

    Raudsepp, Karoliina

    2011-01-01

    Eesti presidendiks valiti taas Toomas Hendrik Ilves. Teine presidendikandidaat Indrek Tarand sai 25 häält. Presidendivalimiste päeval toimus Toompeal presidendi otsevalimise pooldajate meeleavaldus. Väljavõte presidendi kõnest

  16. Otsekui Kaval-Ants ja Vanapagan klassiku näidendis / Enn Siimer

    Index Scriptorium Estoniae

    Siimer, Enn, 1946-

    2009-01-01

    Ugala suvelavastus, Kalju Komissarovi lavastatud Bertolt Brechti "Härra Punttila ja tema sulane Matti". Mängitake Ugala tiigi kõrvale ehitatud laval. Osades: härra Punttila - Peeter Tammearu, sulane Matti - Indrek Sammul

  17. Majanduskriis, vabadussammas, Barack Obama...

    Index Scriptorium Estoniae

    2008-01-01

    Ettevõtja Indrek Neivelt, TLÜ rektor Rein Raud, filmitegija Andres Maimik, peaminister Andrus Ansip, ajakirja Vikerkaar peatoimetaja Märt Väljataga, filmitegija Ilmar Raag avaldavad arvamust, millega läheb 2008. aasta ajalukku

  18. Mobiiliga saab hakata andma digitaalallkirja / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2007-01-01

    EMT hakkab väljastama mobiiltelefoni SIM-kaarte, mis võimaldavad anda digitaalset allkirja. EMT lisateenuste ärijuhi Indrek Östermani selgitus. Lisad: Mobiiliga saab internetipanka minna ja digitaalallkirja anda; Keskkond muutub turvalisemaks

  19. Moodne Magnum kasutab tipptaset / Tanel Raig

    Index Scriptorium Estoniae

    Raig, Tanel, 1975-

    2008-01-01

    Logistikateo konkursil esikoha saanud Magnum Logisticsi uus ladu on omataolistest Ida-Euroopas moodsaim. Vt. samas: Aasta logistikateo finaali jõudnud tööd olid suunatud efektiivsusele. Kommenteerivad Erki Lehiste ja Indrek Reismann

  20. Muusikud on koolitatud palgamõrvareiks / Kai Kallastu ; interv. Karol Kallas

    Index Scriptorium Estoniae

    Kallastu, Kai, 1970-

    2007-01-01

    Lauljanna oma eelseisvast esietendusest : Pärnu mudaravilas esietendub täna Sven Kivisildniku audiovisuaalne ooperietendus "Topeltwagner juustuga", teostajaks lavastuse meeskond REPOO ENSEMBLE (Kivisildnik, Andrus ja Kai Kallastu, Indrek ja Leonora Palu, Rein Laos)

  1. Lugudest läbi põimunud turundus / Ketlin Rauk

    Index Scriptorium Estoniae

    Rauk, Ketlin

    2011-01-01

    Populaarne viis nii ettevõtte sise- kui ka välisturunduses on lugude jutustamine (storytelling). Koolitajate Anu-Mall Naaritsa, Indrek Maripuu ja Ruti Einpalu kogemused. Swedbanki turundusosakonna juhataja Ines Estrin panga uuest reklaamikonseptsioonist

  2. Europarlament kritiseeris Briti peaministri käitumist / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2011-01-01

    Euroopa Parlamendis kritiseeriti Suurbritannia otsust jääda välja Euroopa Liidu uuest valitsustevahelisest rahanduskokkuleppest. Euroopa Ülemkogu peamised otsused 9. detsembril. Indrek Neivelti ja Urmas Varblase esinemisest Riigikogus 13. dets.

  3. Põlvamaa veeprojektidesse paigutatakse ligi 157 miljonit / Raivo Sihver

    Index Scriptorium Estoniae

    Sihver, Raivo

    2008-01-01

    AS-i Põlva Vesi juhataja Olev Elmik ja AS-i Water Ser tegevjuht Indrek Hiiemäe allkirjastasid Põlvamaa veeprojekti 22 ehituslepingust neli Räpina lepingut. 85% rahast tuleb EL-i Ühtekuuluvusfondist

  4. Very Complicated, indeed! / Jürgen Rooste

    Index Scriptorium Estoniae

    Rooste, Jürgen, 1979-

    2005-01-01

    Marco Laimre ja Killu Sukmiti näitus "Very Complicated Rock'n'Roll" Kunstihoone galeriis kuni 22. V. Heli: Indrek Pinsel, Andres Lõo, Riho Sibul, Erkki-Sven Tüür, Rainer Jancis (heliinstallatsiooni seadmine)

  5. Tallink City arendus venib / Ralf-Martin Soe

    Index Scriptorium Estoniae

    Soe, Ralf-Martin

    2008-01-01

    Ligi 5 miljardit krooni maksva Tallink City arendus seisab ametnike sõnul juba pool aastat. Vt. samas: Linn polnud nõus teid välja ehitama; Arendus kui poliitilise kasu allikas. Kommenteerib Indrek Toome

  6. Hunnitud hütid / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2016-01-01

    Arhitektuuribüroos KOKO Arhitektid (Raivo Kotov, Andrus Kõresaar, Sten-Mark Mändmaa, Indrek Mikk, Martin Tago, Liis Uustal, Maia Grimitliht, Raili Paling, Kadri Kaldam) kavandatud puidust matkahütid Norras Skåpetis

  7. Kirjanduslik orgia?! Tänan, ei! / Raul Sulbi

    Index Scriptorium Estoniae

    Sulbi, Raul

    2002-01-01

    Arkaadia järjejutt (juuni - august 2002, autorid Wimberg, Veiko Märka, Urmas Vadi, Jürgen Rooste, Aapo Ilves, Aarne Ruben, Matt Barker, Hedda Maurer, Ivar Sild, Karen Orlau, Indrek Hargla, Jan Kaus, Mehis Heinsaar)

  8. Investeerimisgurud jahivad tugevaid kaubamärke / Peeter Raidla

    Index Scriptorium Estoniae

    Raidla, Peeter, 1955-

    2004-01-01

    Indrek Rahumaa ja Andres Rätsep on loonud mõjuvõimsa investeerimisfirma Alta Capital ning investeerinud tuntud kaubamärkidesse. Kommenteerivad Tõnu Laak ja Tarmo Sumberg. Lisa: Klementist alanud investeeringud on jõudnud Lätti

  9. Uus omanik liidab Kalevi vabriku Poola tehasega / Andrus Karnau

    Index Scriptorium Estoniae

    Karnau, Andrus

    2007-01-01

    Kommivabriku Kalev ja piimatööstuse Tere uus omanik Indrek Rahumaa kavatseb ettevõtted liita Poola kommivabrikuga Mieszko ja Läti piimakombinaadiga Piensaimnieks, mille on ostnud Rahumaa enamusosalusega investeerimisfirma Alta Capital Partners. Lisa: CV

  10. Eestlased vabanesid Riia kombinaadist / Sirje Rank, Kadri Paas

    Index Scriptorium Estoniae

    Rank, Sirje, 1966-

    2010-01-01

    Investeerimispankur Indrek Rahumaa võlakirjade tagatisena Läti ühe suurima piimakombinaadi Rigas Piensaimnieksi suurosanikuks saanud Swedbanki Private Debt Fund ja mitmed Eesti tippinvestorid müüsid oma osaluse USA investeerimisfirmale Darby Overseas Investments

  11. Poliitikud või eksperdid ? / Aarne Ruben

    Index Scriptorium Estoniae

    Ruben, Aarne, 1971-

    2009-01-01

    ETV saates "Foorum" esinesid 21. jaanuaril Indrek Neivelt, Erik Terk, Ivar Raig ja Raivo Vare, kes avaldasid arvamust, et valitsuses oleks vaja rohkem majandusharidusega inimesi. Autori arvates on erialast kõrgharidust vaja kõikjal riigiametites

  12. Kubija Hotell-Loodusspaa = Kubija Hotel-Nature Spa

    Index Scriptorium Estoniae

    2012-01-01

    Võrus Männiku tee 43A asuva Kubija Hotell-Loodusspaa sisekujundusest. Sisearhitektid Tiiu Truus ja Birgit Jaanus (Stuudio Truus). Arhitektid Indrek Tiigi ja Helle-Triin Hansumäe. Loetletud Stuudio Truus tehtud töid

  13. Korraga kolm näitust Endlas

    Index Scriptorium Estoniae

    2002-01-01

    1. augustist Endla Teatrigaleriis maalikunstnik Kaili-Angela Konno isiknäitus "Väikesed hümnid Eestile", fotograafide Toomas Kali isiknäitus "Kuule, too jäätist!" ja Indrek Arula klubikultuurisari "Grooveing Spirit"

  14. Värsked õpipoisid / Indrek Treufeldt

    Index Scriptorium Estoniae

    Treufeldt, Indrek, 1969-

    2004-01-01

    Euroopa Komisjoni kümme uut volinikku asuvad esialgu praeguste ametnike juures õppima protseduurireegleid ja vähem probleemide sisulist lahendamist. Kuna uus Euroopa Komisjon alustab sügisel, tuleb suvel selgeks vaielda, kes saab Romano Prodi järeltulijaks

  15. Teejuht seente maailma / Indrek Sell

    Index Scriptorium Estoniae

    Sell, Indrek, 1983-

    2014-01-01

    Haavataelik, haavanääts, põdramokad, kübarnarmikud, narmikud, kroonliudik, roostetorik, roosa pess, lillatümak, kuusetaelik, poropoorik, tammetaelik, leht-kobartorik, maksak, tammenahkis, tumepruun taelik, volt-tardnahkis, lõhetümak, limatünnik, roostepruun taelik, sarapuu-ebakorgik, lakkvaabik (läikvaabik), haava-tuletaelik (haava-ebatuletael), õrn narmnahkis (õrnnarmik), korallnarmik (harunev korallnarmik), männi-vahakorgik (männikorgik), juurepruunik, narmastaelik, kährikseen (kährik)

  16. Internet ja emakeel / Indrek Tart

    Index Scriptorium Estoniae

    Tart, Indrek

    2003-01-01

    Internet on või(s)tlustanner, kus tähendusrikkalt toimimiseks erinevad kultuurid pingutusi teevad. Efektiivne ja paratamatu on omakeelse-emakeelse vahendkonna loomine veebis tegutsemiseks, sest selleta arenenud kirjakultuuriga riike on raske ette kujutada

  17. Aasta 2011 kevadhooaeg / [Indrek Otsus

    Index Scriptorium Estoniae

    Otsus, Indrek

    2011-01-01

    Eesti Karikavõistlustest kulturismis ja fitnessis, mis toimusid 23. aprillil Tartus Vanemuise kontserdisaalis, Eesti karikavõistlustest athletic fitnessis, mis toimusid 30. aprillil Saaremaal Orissaare Spordihoones, ja Balti matšist, mis toimus 6.-7.maini Riias

  18. Mida loed sina? / Indrek Hargla

    Index Scriptorium Estoniae

    Hargla, Indrek, pseud., 1970-

    2007-01-01

    Tutvustus: Pérez-Reverte, Arturo. Dumas̀ klubi ehk Richelieu vari. Tallinn : Varrak, 2006 ; Belials, Veiko. Jumalate vandenõu. Tallinn : Varrak, 2006 ; Põder, Rein. Eike. Tallinn : Eesti Raamat, 2006 ; Reeve, Philip. Kuldseeklid. Tallinn : Tiritamm, 2006 ; Martin, George R. R. Troonide mäng. Esimene raamat / tlk. Mario Kivistik. Tallinn : Varrak, 2006. (Jää ja tule laul) (F-sari)

  19. "Neiseri" büroohoone = The Neiser Office Building / Piret Lindpere

    Index Scriptorium Estoniae

    Lindpere, Piret, 1963-

    2003-01-01

    2002. a. valminud kontori sisekujundusest. Sisearhitekt Tiiu Truus. Hoone arhitekt Indrek Näkk. Kontorimööbli ja lükanduksed valmistas Võru firma "Private Project". Bürooseintel Rein Kelpmani maalid. Ill.: kontori planeering, 6 vaadet

  20. Robin Sharma : juhtimine on lihtne / Robin Sharma ; intervjueerinud Nelli Pello

    Index Scriptorium Estoniae

    Sharma, Robin

    2008-01-01

    Eestit külastanud maailma tunnustatumaid koolitajaid Robin Sharma, kes viis läbi seminari "Eestvedamise meistriklass", vastab küsimustele Eesti-muljete ja juhtimise kohta. Lisa: Robin Sharma mõtteteri. Kommenteerivad: Indrek Pertelson, Anne Samlik

  1. Tartu Tervishoiu Kõrgkool = Tartu Health Care College / Ingrid Ruudi

    Index Scriptorium Estoniae

    Ruudi, Ingrid, 1978-

    2012-01-01

    2012. aastal valminud Tartu Tervishoiu Kõrgkooli hoone arhitektuursest lahendusest. Arhitektid Indrek Peil ja Siiri Vallner, kaasautorid Johannes Feld, Sten-Mark Mändmaa, Andro Mänd ja Ragnar Põllukivi (Kavakava). Sisearhitekt Tarmo Piirmets (Pink). Projekt: 2006-2009

  2. Pärnu Kontserdimaja arhitektuurikonkurss = Architectural Competition of Pärnu Concert Hall / Martti Preem

    Index Scriptorium Estoniae

    Preem, Martti, 1949-

    2001-01-01

    Asukohavalikust, premeeritud ja äramärgitud töödest. Konkursi tulemused: I preemia - Hanno Grossschmidt, Katrin Koov, Kaire Nõmm, Üla Koppel; II - Indrek Erm, Emil Urbel; III - Kalle Komissarov, Andres Ojari. 21 ill.

  3. 3D-animatsii na stroitelnom rõnke - eto elitnõi tovar / Priit Rum

    Index Scriptorium Estoniae

    Rum, Priit

    2006-01-01

    Praegu on 3D-visualisatsioonide põhilisteks tellijateks kinnisvaraarendajad ja arhitektuuribürood. Kommenteerivad Agor Eiskop, Indrek Tiigi, Margus Triibmann, Piret Piirsoo, Merle Väli. Ill.: Fahle maja, Allika t. 12 korterelamu ja Merirahu elamurajoon Tallinnas

  4. Vennalik maja = A Brotherly House / Liina Jänes

    Index Scriptorium Estoniae

    Jänes, Liina, 1977-

    2002-01-01

    2001. a. Tallinnas Pirita teel valminud eramu projekteeris Arhitektibüroo Emil Urbel. Arhitektid Emil Urbel ja Indrek Erm, sisearhitekt Taso Mähar. Konstruktsioonid: E-Inseneribüroo. 5 ill.: korruste plaanid, sisevaade, välisvaated

  5. Eesti Post sukeldub kiirlaenuärisse / Dannar Leitmaa

    Index Scriptorium Estoniae

    Leitmaa, Dannar, 1982-

    2008-01-01

    Eesti Post pakub katseprojekti raames isikusamasuse tuvastamise teenust viiele kiirlaenu pakkuvale firmale. Parlamendiliikmete Indrek Raudse ja Evelyn Sepa ning Tallinna Sotsiaaltöökeskuse sotsiaalteenuste osakonna juhataja Eve Võrgu kommentaarid. Lisa: Ministeerium: kõik on seaduslik

  6. Muusika : Hortus Musicus Moskvas. Eesti Rahvusmeeskoor Toulouse'is. Joaquín Rodrigo 100. Georg Ots kuuel plaadil. "Kiriku laulu- ja palveraamat" ئ 10. "Vikerraadio" heategevuskontsert. Artur Kapi ühingu esimees on Andres Uibo / Vello Mäeots

    Index Scriptorium Estoniae

    Mäeots, Vello, 1940-2015

    2001-01-01

    20. XI esines Hortus Musicus Moskvas Eesti saatkonnas. Eesti Rahvusmeeskoor kandis 15.XI Toulouse'is koos Toulouse'i Rahvusliku Linnaorkestriga ette Jean Sibeliuse "Kullervo". 22.XI tähistatakse hispaania helilooja Joaquín Rodrigo 100. sünniaastapäeva. Estonia teatri Valges saalis esitleti kogumik-CD-d "Georg Ots ئ Anthology". "Kiriku laulu- ja palveraamat" sai 30.XI 10. aastaseks. 3.XII toimub Tallinnas Kaarli kirikus "Vikerraadio" heategevuskontsert "Aita alustada elu". 26.X asutati Suure-Jaanis Rahvusvaheline Artur Kapi Ühing, mille esimeheks valiti organist Andres Uibo

  7. Objekt nr 2011 / Liina Siib, Signe Kivi, Vilen Künnapu ...[jt.

    Index Scriptorium Estoniae

    2011-01-01

    Installatsioon "Objekt nr. 2011" Tallinnas Vabaduse väljakul 27.02.-20.03.2011. Arvamust avaldavad kuplis objektiks olnud. Installatsiooni autorid: Mart Koldits, Kaarel Oja, Iir Hermeliin, Indrek Tiigi, Kadri Tamre, Kadri Tikerpuu, Sirli Bergström

  8. Kirjandusteosed läbisid esimese sõelumise / Inna Grünfeldt

    Index Scriptorium Estoniae

    Grünfeldt, Inna, 1961-

    2006-01-01

    Virumaa selle aasta kirjandusauhinnale kandideerivad Ave Alavainu "Minekulaulud", Toomas Haugi "Troojamäe tõotus", Enn Nõu "Mõtusekuke viimne kogupauk", Olavi Ruitlase "Kroonu", Olivia Saare "Humalapuu", Indrek Hargla "French ja Koulu" ja Eevi Taeli "Lapse silmadega Narvast"

  9. Swedbank ei pikenda Rumeenia fondi võlakirju / Piret Reiljan

    Index Scriptorium Estoniae

    Reiljan, Piret, 1983-

    2010-01-01

    Swedbank ei pikendanud IPC Investment Groupi poolt hallatava Rumeenia kinnisvarafondi Nord Hill Land Portfolio tähtaega ning fond peab vara müüki panema. IPC Investment Groupi omanikud on Indrek Elhi ja rumeenlane Ciprian Lopata

  10. 212ʻ Fahrenheiti : eesti luule 2006 / Piret Bristol

    Index Scriptorium Estoniae

    Bristol, Piret, 1968-

    2008-01-01

    Järgmistest 2006. a. ilmunud luulekogudest: Ryytle, Indrek. Inglid rokijaamas. Puhja : I. Rüütle ; Runnel, Hando. Viru veri ei värise. Tartu : Ilmamaa ; Vabat, Martin. Mina olengi kirjandusklassik. Tartu : Eesti Kirjanduse Selts ; Korts, Eliina. Lööklaused murravad metsi. Tartu : Eesti Kirjanduse Selts ; Koff, Indrek. Vana laul. Luige : Verb ; Teede, Andra. Takso Tallinna taevas. Luige : Verb ; Vusser, Kaspar. Vusserduste võnked. Tallinn : P. Kukk ; Elbing, Andrus. Siin Beebilõust, tere! : häired pimelinna tänavalt = Ciao, it's Babyface : trouble from the streets of a blind city. Tallinn : Epifanio ; Hint, Miina. Vabaduse vang, ehk, Põrandaalune kirjandus. Tallinn : MR ; Jüriado, Tiiu. Luule on ime. Habaja : Kentaur ; Ligi, Katre. Naabrivalve. Tartu : Ilmamaa ; Krull, Hasso. Talv. Tallinn : Tuum ; Mets, Mae. Pühapäeval on reede. Tartu : Ilmamaa ; Ploom, Ülar. Porr ja sorry. Tallinn : Tuum ; Hirv, Indrek, Surmapõletaja. Tallinn : Tuum ; Piir, Milvi Martina. Kõrkjavaas. Tartu : Fantaasia ; Soomets, Triin. Väljas. Tallinn : Tuum ; Mathura. Kohalolu. Rapla : Allikäärne ; Afanasjev, Vahur. Katedraal Emajões. Tartu ; Brüssel : ID Salong//Sild, Ivar. Spermaga ja puha. Pärnu : Jumalikud Ilmutused ; Meiel, Kaupo. Polügrafisti käsiraamat. Pärnu : Jumalikud Ilmutused ; Kivisildnik, Sven. Vägistatud jäämägi. Pärnu : Jumalikud Ilmutused ; Arder, Ott. Luule sünnib kus sünnib kui sünnib / koost. Leelo Tungal. Tallinn : Tänapäev ; Kompus, Marko. Vallaliste jõgede tõkkejooksja. Tartu : M. Kompus

  11. Tartu Tervishoiu Kõrgkool = Tartu Health Care College

    Index Scriptorium Estoniae

    2015-01-01

    Tartu Tervishoiu Kõrgkool Nooruse tänav 5, valminud 2011. Arhitektid Indrek Peil, Siiri Vallner (Kavakava), kaasautorid Johannes Feld, Sten-Mark Mändmaa, Andro Mänd, Ragnar Põllukivi. Sisearhitekt Tarmo Piirmets (Pink). Konstruktorid Ivar Muuk, Andres Hirve (Pike)

  12. Betonnoje sooruzhenije goda - most Puurmani

    Index Scriptorium Estoniae

    2008-01-01

    Konkursi "Aasta Betoonehitis 2007" võidutöö on Puurmani kaarsild. Konstruktorid Siim ja Juhan Idnurm. Arhitekti eriauhinna pälvisid Siiri Vallner, Indrek Peil ja Sten-Mark Mändmaa Tartus asuva Lotte lasteaia projekteerimise eest. Teisi auhinnasaajaid

  13. Content and form / Margus Tamm

    Index Scriptorium Estoniae

    Tamm, Margus, 1977-

    2012-01-01

    Eesti Tarbekunsti- ja Disainimuuseumis 21.04.-17.06.2012 toimunud näitusest "Sisu ja vorm I. Kaasaegne Eesti graafiline disain 2001-2011", selle koostamise põhimõtetest. Kuraator Indrek Sirkel. Näituse kataloogist "Sisu ja vorm. II"

  14. Prezentatsija fotovõstavki v klube Astoria Palace

    Index Scriptorium Estoniae

    2007-01-01

    Fotograafide Artur Sadovski ja Indrek Galetini fotonäituse "Eludraama" esitlus koostöös moekunstnik Marin Sillaga Tallinna ööklubis Astoria Palace. Alates 13. augustist eksponeeritakse Sadovski ja Galetini fotosid Rahvusraamatukogus. Lisatud 8 värvifotot

  15. "Hingelindude" lend / Igor Garšnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2010-01-01

    Tallinna Filharmoonia kontserdisarjas "Viva oratorio!" 2. novembril Tallinna Jaani kirikus toimunud Rein Rannapi koori-orkestriteose "Hingelinnud I" (tekst Indrek Hirv) esiettekandest. Esitasid ETV mudilaskoor, lastekoor ja vilislased ning Tallinna Kammerorkester Toomas Vavilovi dirigeerimisel, solistid Bonzo ja Kaisa Padur

  16. City Plaza büroohoone : Tartu mnt. 2, Tallinn = City Plaza office building : Tartu maantee 2, Tallinn

    Index Scriptorium Estoniae

    2006-01-01

    Arhitektid: Tiit Trummal, Andres Alver, Martin Melioranski, Indrek Rünkla, AB Alver Trummal Arhitektid. Eesti Kultuurkapitali arhitektuuri sihtkapitali 2005. a. objektipreemia. Žürii liikme Ado Eigi arvamus. 5 värv. välis- ja 4 sisevaadet

  17. Kanepikasvatajate unine suvi / Jüri Ehlvest

    Index Scriptorium Estoniae

    Ehlvest, Jüri, 1967-2006

    2002-01-01

    Arkaadia järjejutust, ilmus juuni - august 2002 Eesti Päevalehes, autorid: Wimberg, Veiko Märka, Urmas Vadi, Jürgen Rooste, Aapo Ilves, Aarne Ruben, Matt Barker, Hedda Maurer, Ivar Sild, Karen Orlau, Indrek Hargla, Jan Kaus, Mehis Heinsaar

  18. The Yukos Crisis Brings Thunderclouds to the Railway Carriage Business / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2004-01-01

    Russian Estonian Rail Services AS - kõige konkurentsivõimelisem transpordi-, side- ja logistikaettevõtete hulgas, Hansapanga kõrgepalgalise eksportööri eriauhinna laureaat. Lisa: Russian Estonian Rail Services 2003. Kommenteerib Indrek Neivelt. Tabel: Transpordi-, side- ja logistikaettevõtted

  19. Eesti Ajaloomuuseumi Suurgildi hoone. Püsinäitus "Visa hing. 11 000 aastat Eesti ajalugu" = Restoration of the Estonian History Museum Great Guild Hall building, permanent exhibition "Spirit of survival. 11,000 years of Estonian history" / Margit A

    Index Scriptorium Estoniae

    Argus, Margit, 1981-

    2012-01-01

    Suurgildi hoone renoveerimisest, sisekujundusest, ekspositsioonist. Sisearhitektid Margit Aule, Liis Lindvere, Margit Argus (Koko Arhitektid). Restaureerimisarhitekt: Mart Keskküla (Restor). Graafilise disaini autorid Jan Tomson, Indrek Sirkel, Mikk Heinsoo, Kaarel Nõmmik, Andrus Kõresaar (Produktsioonigrupp). Ekspositsiooni multimeedia ja interaktsioon: Produktsioonigrupp

  20. Mastaapse narkoäri paljastamine jooksis liiva / Jaan Väljaots

    Index Scriptorium Estoniae

    Väljaots, Jaan, 1968-

    2004-01-01

    Toomas Helin, Indrek Sürje ja Märt Joller, keda seostatakse marihuaana ja ecstasy Eestisse toomise katsega, mõisteti süüdi vaid väikese koguse kemikaalide kokkuostu eest. Kohtunik Merle Parts nimetas meeste kriminaalasja uurimist puudulikuks

  1. Luulelaat vaimuväljadel / Priidu Beier

    Index Scriptorium Estoniae

    Beier, Priidu, 1957-

    1997-01-01

    Arvustus: Rahman, Jan. Vasõst vask; Serpent, François. Ka Jumal on inimene; Märka, Veiko. Tühja aju korinad; Rüütle, Indrek. Lahkumine Puhjast (kõik Eesti Kostabi Seltsi Kaasaegse Kirjanduse Keskuse väljaanded, 1997)

  2. Sõjast väsinud maa

    Index Scriptorium Estoniae

    2004-01-01

    Oma kogemustest Bagrami lennubaasis Afganistanis räägivad Eesti Päästemeeskonna demineerimismissiooni liikmed Jaanus Vahersalu, Jaan Ohtra, Kaukko Kiisk, Toomas Sims, Tõnu Mägi, Raido Taalmann, Indrek Samm, Kalvar Tammine, Kaido Kaurit, Rauno Saareleht ja Pille Volmerson

  3. Parts : ministrite minevik olgu avalik / Juhan Parts ; interv. Toomas Sildam

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2003-01-01

    Peaminister Juhan Parts vastab küsimustele, mis on seotud politseinike altkäemaksu andmise avalikuks tulekuga, komissar Indrek Sirgi ametist lahkumisega ja ministrite seadusrikkumiste avalikustamisega. Kommenteerivad: Margus Leivo, Tarmo Loodus, Ain Seppik. Vt. samas: Valik saladuses peetavast teabest

  4. "Hall piirkond", kuhu upuvad infolaevad / Jaanus Kosemaa

    Index Scriptorium Estoniae

    Kosemaa, Jaanus

    1997-01-01

    Informatsiooni avalikustamisest vastavalt Tallinna Väärtpaberibörsi reglemendile. Kommenteerivad Tallinna Väärtpaberibörsi juhatuse esimees Helo Meigas, HF Kapitali tegevdirektor Margus Uudam, Hansapanga Eesti peadirektor Indrek Neivelt ja Kaubandus-Tööstuskoja tegevdirektor Toomas Tamsar

  5. Akt valgel hobusel ja tütarlaps lillega / Tambet Kaugema

    Index Scriptorium Estoniae

    Kaugema, Tambet

    2000-01-01

    Riose kunstioksjonil müüdud piltidest ja nende müügihinnad. Indrek Hirve kommentaare müügilolnud tööde kohta. Detsembri alguses kuulutab galerii välja esimese online-kunstioksjoni, aadressil www.rios.ee

  6. Miks? Ehk jätkuks sellele, millest tol õhtul rääkisime = Why? Or to continue from where we left off the other night / Kadri Klementi

    Index Scriptorium Estoniae

    Klementi, Kadri

    2011-01-01

    Külalistoimetaja Kadri Klementi Eesti arhitektuuri ajakirja "Maja" 2011. aasta kolmandast numbrist "Maja taga", mille teemaks on asjad arhitektuuri ümber. Number on pühendatud Linnalabori viiendale sünnipäevale. Graafiline disain: Kaarel Nõmmik, Indrek Sirkel

  7. Jukose kriis toob äikesepilved vaguniäri kohale / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2004-01-01

    Russian Estonian Rail Services AS - kõige konkurentsivõimelisem transpordi-, side- ja logistikaettevõtete hulgas, Hansapanga kõrgepalgalise eksportööri eriauhinna laureaat. Lisa: Russian Estonian Rail Services 2003. Kommenteerib Indrek Neivelt. Tabel: Transpordi-, side- ja logistikaettevõtted

  8. Patrones de relación entre información biológica e información física y socioeconómica : cuenca alta del Río Otún, Risaralda Colombia

    OpenAIRE

    Coronel Picón, Yulieth Rossio

    2009-01-01

    En este trabajo se realizó un análisis de información física, socioeconómica y biológica de la cuenca del río Otún. Se presenta la metodología utilizada para la identificación de patrones de relación entre la información física y socioeconómica de la cuenca y la presencia de algunos mamíferos identificados en esta zona, y los resultados obtenidos. La identificación de patrones se llevó a cabo mediante la aplicación de árboles de decisión, utilizando el algoritmo j-48 desarrollado en el entorn...

  9. Results of investigations conducted in the LaRC 4-foot unitary plan wind tunnel leg no. 1 using the 0.010-scale 72-OTS model of the space shuttle integrated vehicle (IA94A)

    Science.gov (United States)

    Nichols, M. E.

    1976-01-01

    Aero-loads investigations were conducted on the updated configuration-5 space shuttle launch vehicle at Mach numbers 2.50, 3.50, and 4.50. Six-component vehicle forces and moments, base and sting-cavity pressures, elevon hinge moments, wing-root bending and torsion moments, and normal shear force data were obtained. Full simulation of updated vehicle protuberances and attach hardware was employed. Various elevon deflection angles were tested, with two different forward orbiter-to-external-tank attach-strut configurations. The entire vehicle model 72-OTS was supported by means of a balance mounted in the orbiter through its base and suspended from an appropriate sting for the specific tunnel.

  10. Eesti Tervishoiu Muuseum = Estonian Health Care Museum / Raili Paling, Liis Lindvere, Kadri Kaldam ; kommenteerinud Kadri Liimal

    Index Scriptorium Estoniae

    Paling, Raili

    2016-01-01

    Eesti Tervishoiu Muuseumi (Tallinn, Lai tn. 30) renoveeritud interjöör ja püsiekspositsioon. Autorid Jelena Altmäe, Kadri Kaldam, Andrus Kõresaar, Indrek Mikk, Jaanus Männik, Lea Laidra, Liis Lindvere, Raili Paling; kuraator Ülle Kask

  11. Kuulsuste keeruline elu : [anekdoodid] / Toomas Kall ; karikatuur: Rein Lauks

    Index Scriptorium Estoniae

    Kall, Toomas, 1947-

    2014-01-01

    Anekdoodid järgmistest kuulsustest: Luisa Värk, Taavi Rõivas, Ardo Hansson, Bill Gates, Nicolas Sarkozy, Dmitri Medvedev, Edgar Savisaar, Vladimir Putin, Anton Vaino, Astrid Kannel, Viktor Janukovitš, Evelin Ilves, Toomas Hendrik Ilves, Jürgen Ligi, Urve Palo, Indrek Tarand

  12. Volta kvartali kujundab Soome arhitektuurifirma / Eneken Laasme

    Index Scriptorium Estoniae

    Laasme, Eneken

    2007-01-01

    Volta kvartali kutsutud osalejatega arhitektuurivõistlusest. I koha pälvis Soome arhitektuuribüroo AW2 Arkkitehtit, II -AB Kosmos, III - KOKO Arhitektid. Žürii koosseis. Kommenteerivad Veiko Veskiväli, Ülar Mark, Indrek Allmann, Matti Anttila

  13. Zavodõ jest, biodizelja - net / Viktor Filonenko

    Index Scriptorium Estoniae

    Filonenko, Viktor, 1949-

    2008-01-01

    Eestis on viimastel aastatel loodud mitu biodiislit tootvat ettevõtet, kuid Eestis puuduva nõudluse tõttu biodiislit siin ei müüda. Vt. samas: Taimsest toorainest valmistatakse kütust Paldiskis. Kommenteerivad Kai Realo, Indrek Kaju ja Sven Mark

  14. Olympic seljatas oodatud käibe / Tarvo Vaarmets

    Index Scriptorium Estoniae

    Vaarmets, Tarvo

    2008-01-01

    Olympic Entertainment Groupi 2007. aasta neljanda kvartali käive oli 799 miljonit krooni. Tänu tugevale aasta lõpule edestas ettevõte nii enda korrigeeritud aastaprognoosi kui ka analüütikute ootusi. Diagramm: Käive. Kommenteerib Indrek Kuivallik

  15. Poolsajandi õnnesoovid Jaak Aaviksoole / Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar...[jt.

    Index Scriptorium Estoniae

    2004-01-01

    Mõtteid Tartu Ülikooli rektorist tema 50. sünnipäeva puhul : Ain Heinaru, Jaak Kangilaski, Tõnu Lehtsaar, Indrek Reimand, Toomas Kiho, Leelo Kriisa, Peeter Olesk, Risto Tammelo, Birute Klaas, Peeter Saari, Andrus Ansip, Mait Klaassen, Marika Kullamaa, Kaupo Bend

  16. Rahumaa lihvib ostetud firmadest liidreid

    Index Scriptorium Estoniae

    2007-01-01

    Indrek Rahumaa juhitav Eesti Investeerimisgrupp Alta Capital Partnerson on omandanud lühikese ajavahemikuga Läti ühe suurema ehitusettevõtte LEC ning suurima piimatööstuse Rigas Piensaimnieks, eesmärgiks on kasvatada ostetud ettevõtetest regionaalsed liidrid

  17. Dzhentelmenide kätsh / Hannes Sarv

    Index Scriptorium Estoniae

    Sarv, Hannes

    2008-01-01

    AS Alta Foods esitas Stockholmi arbitraazhiinstituudile taotluse, et saada tagasi AS-i Kalev toiduainetööstuse ja AS-i Tere omandamiseks tasutud kuue miljoni euro suurune ettemaks. Vt. samas: Tehingu kronoloogia. Küsimustele vastavad Indrek Rahumaa ja Oliver Kruuda

  18. Kruuda kurb mäng

    Index Scriptorium Estoniae

    2010-01-01

    Oliver Kruuda müüs oma võlakoorma vähendamiseks Kalevi Norra toiduainekontsernile Orkla. Kalevi ja Tere müümine oli tal plaanis ka 2007. aastal, kui Indrek Rohumaa juhitud investeerimisfirma Alta Capital pidi need ära ostma

  19. Rocca al Mare kool = Rocca al Mare School / Piret Lindpere

    Index Scriptorium Estoniae

    Lindpere, Piret, 1963-

    2000-01-01

    Projekteerija Arhitektuuribüroo Urbel ja Peil. Arhitektid Emil Urbel, Indrek Erm, sisekujundaja Taso Mähar. Peatöövõtt: KMG Ehitus AS. Projekt 1999, hoone valmis 2000. 23 ill. Asendiplaan, korruste plaanid, pikilõiked, sise- ja välisvaated

  20. Alta Capital investeerib miljardeid kroone / Raigo Neudorf

    Index Scriptorium Estoniae

    Neudorf, Raigo

    2006-01-01

    Investeerimisfirma Alta Capital nõukogu esimees Indrek Rahumaa annab ülevaate sellest, kuidas ettevõte on lühikese ajaga suutnud omandada osaluse mitmetes ettevõtetes ning suunanud neisse investeeringuid 150 miljoni euro väärtuses. Vt. samas: Osalused; Omanikud

  1. Noorte looming : [luuletused

    Index Scriptorium Estoniae

    2007-01-01

    Sisu: Kuked ja kanad / Laura Trull ; "Ma igatsen õnne..." / Kattre Adramees ; Usk / Riinu Ansperi ; Talveüllatus / Aile Eldemeel ; Vastutus / Riinu Ansperi ; Pisike peni / Indrek Kuka ; Tere, talv! / Villi Brandt ; Minu kool / Kaisa Tamm ; Selle teeraja mälestuseks / Anni Vanin

  2. Eesti kirjandus 1997

    Index Scriptorium Estoniae

    1998-01-01

    Aut.: Märt Väljataga, Mart Velsker, Barbi Pilvre, Indrek Särg, Tarmo Vahter, Piret Viires, Tõnu Kaalep, Janika Kronberg, Lauri Sommer, Sven Kivisildnik, Eve Annuk, Aarne Ruben, Jan Kaus, Karl Martin Sinijärv, Jüri Ehlvest, Hasso Krull

  3. The lacuna, an empty space in urban construction. Cesare Brandi's restoration theory in the integral preservation of old town areas / Lilian Hansar

    Index Scriptorium Estoniae

    Hansar, Lilian, 1949-

    2008-01-01

    Cesare Brandi (1906-1988) restaureerimisteooriast ja vanalinna kui kunstiteose terviklikust säilitamisest, uute hoonete sulandamisest ning renoveerimisest. Ka Ferrumi Kaubamaja uue hoone heast sobivusest Kuressaare vanalinna - arhitektid Andres Alver, Tarmo Laht, Indrek Rünkla, Ulla Mets ja Tiit Trummal

  4. Üleilmsed krediitkaardipettused tabavad üha enam ka Eestit / Toomas Vaks

    Index Scriptorium Estoniae

    Vaks, Toomas

    2005-01-01

    28.-30. septembrini Tallinnas toimunud kolmandast kaardipettuste foorumist "Baltic Scandinavian Fraud Forum". Krediitkaardipettuste ja e-kuritegevuse sagenemise põhjustest. Kaart: Kaardipettuste skeem võib olla kontinentidevaheline. Lisa: Krediitkaartide roll maailmas suureneb. Kommenteerib Politseiameti politseitöö osakonna politseidirektor Indrek Tibar

  5. Kihnu muuseum = Kihnu museum

    Index Scriptorium Estoniae

    2011-01-01

    Eesti Sisearhitektide Liidu 2010. a. ajaloolise interjööri preemia pälvinud Kihnu muuseumist. Sisearhitektid: Malle Jürgenson, Tea Tammelaan, Krista Lepland (Laika, Belka & Strelka OÜ), loetletud nende ühiselt tehtud töid. Arhitektid: Jaak Huimerind, Indrek Laos

  6. Kes tahab elada raudtee ääres? : kortermajad Õie tn. 2 Nõmmel = WhoWants to Live Next to the Railway? : apartment buildings Õie St. 2 in Nõmme / Piret Lindpere

    Index Scriptorium Estoniae

    Lindpere, Piret, 1963-

    2005-01-01

    Kolm viie korteriga kolmekorruselist korterelamut. Projekteerija: Arhitektuuribüroo Pluss. Autor Indrek Allmann. Konstruktsioonid: E-Inseneribüroo. Detailplaneering: Koot & Koot. Projekt: 2003, valmis: 2005. Ill.: katusekorruse ja tüüpkorruse plaan, 5 värv. välisvaadet

  7. Pilistvere rehehoones tapetakse Rasputin / Kaarel Aluoja

    Index Scriptorium Estoniae

    Aluoja, Kaarel

    2008-01-01

    7. aug. Pilistvere vanas rehehoones esietendunud Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse tõi välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar

  8. Rasputin - lugu rahva latvade juurimisest / Kati Murutar

    Index Scriptorium Estoniae

    Murutar, Kati, 1967-

    2008-01-01

    7. aug. Pilistvere vanas rehehoones esietendunud Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse tõi välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar

  9. Pilistvere vana rehe all päästetakse Venemaad / Krista Valdvee

    Index Scriptorium Estoniae

    Valdvee, Krista, 1978-

    2008-01-01

    7. aug. Pilistvere vanas rehehoones esietendunud Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse tõi välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar

  10. Pilistveres saab homme kohtuda Rasputiniga / Ülle Lätte

    Index Scriptorium Estoniae

    Lätte, Ülle, 1955-

    2008-01-01

    7. aug. Pilistvere vanas rehehoones esietenduvast Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse toob välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar

  11. Ellunäod toovad välja "Rasputini" / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2008-01-01

    7. aug. Pilistvere vanas rehehoones esietenduvast Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse toob välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar

  12. Pilistveres tegutseb Rasputin / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2008-01-01

    7. aug. Pilistvere vanas rehehoones esietenduvast Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse toob välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar

  13. Rasputin : Rahvakese jaoks on vaja elada / Margus Mikomägi

    Index Scriptorium Estoniae

    Mikomägi, Margus, 1956-

    2008-01-01

    7. aug. Pilistvere vanas rehehoones esietendunud Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse tõi välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar

  14. Edukaks töö ja arengu kaudu / Ketlin Priilinn

    Index Scriptorium Estoniae

    Priilinn, Ketlin, 1982-

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti 2. veebr. lk. 11. TOP-i 2. koht. Ehituse, kaevetööde ja kinnisvaraga tegeleva Malkati Kaubanduse OÜ juhatuse liikme Indrek Puhalaineni sõnul on ettevõtet edule aidanud aktiivne töö. Diagramm

  15. Eramu Suurupis = A House in Suurupi / Tiina Mang

    Index Scriptorium Estoniae

    Mang, Tiina

    2002-01-01

    2002. a. valminud eramu projekteeris Arhitektibüroo Emil Urbel. Arhitektid Emil Urbel ja Indrek Erm, sisearhitekt Tiina Mang, konstruktor Peep Rosenberg. Projekt 2000-2001. 7 ill.: I korruse plaan, sise- ja välisvaated.Emil Urbel (arhitektibüroo).

  16. Veneetsiasse läheb teaduse ja kunsti ühendus

    Index Scriptorium Estoniae

    2006-01-01

    Veneetsia X arhitektuuribiennaalil esitletakse sotsiaalse positsioneerimise meetodi (SPM) ehk reaalajas toimuva linnaplaneerimise keskkonna projekti. Väljapaneku loojad on arhitektuuribüroo Urban Mark (Ülar Mark, Kaja Pae, Indrek Tiigi) ja Tartu Ülikooli geograafiainstituut (Rein Ahas, Anto Aasa, Siiri Silm)

  17. Poska 28 elamust : kortermaja Tallinnas Kadriorus = About the Multi-Family Dwelling at Poska 28 : Apartment House in KadriorgTallinn / Tiit Trummal

    Index Scriptorium Estoniae

    Trummal, Tiit, 1954-

    2002-01-01

    Projekteerija: Alver Trummal Arhitektid. Autorid Tiit Trummal, Tarmo Laht, Ulla Mets. Konstruktsioonid: Aivar Lukk, Indrek Einloo. Üheksa korteriga elamul on avarad terrassid, rõdudele avanevad vannitoad jm. Projekt 2001, valmis 2002. 7 ill.: vaated, tüüpkorruse plaan

  18. Uue aja moodne kodu ja ajaloo ringkäik / Karin Hallas-Murula

    Index Scriptorium Estoniae

    Hallas-Murula, Karin, 1957-

    2001-01-01

    1927. a. Stuttgarti ehitatud Weissenhofi väikemajade elamurajoonist (Mies van der Rohe, Le Corbusier, W. Gropius, M. Taut jt.) näituse "Weissenhof" põhjal Rotermanni soolalaos. Võrreldakse Emil Urbeli ja Indrek Ermi Aaviku küla projektiga Tiskres

  19. Mehed ilumaailmast / Krista Dudarenko

    Index Scriptorium Estoniae

    Dudarenko, Krista, 1970-

    2007-01-01

    Vestlusringis osalevad Lumene Eesti OÜ tegevdirektor Indrek Lepik, ASi Pariisi Vesi omanik ja juht Nils Niimann, L'Oreali massikosmeetika müügijuht Ivo Rundans, Riviera Internationali juht Antoine Stecken, Sirowa Grupi direktor Juergen Warzecha ning omanimelise kosmeetikafirma omanik Heino Puuste

  20. Müügijuhi suurim oht on võõrduda tööst / Villu Parvet

    Index Scriptorium Estoniae

    Parvet, Villu, 1979-

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti 5. okt. lk. 617 Suur osa müügijuhte kipub juhtkonda sattudes kiiresti võõrduma oma eelnevast müügitööst. Kommenteerivad: Andres Huul, Margus Müts ja Indrek Soom

  1. Urinary and plasma oxytocin changes in response to MDMA or intranasal oxytocin administration.

    Science.gov (United States)

    Francis, Sunday M; Kirkpatrick, Matthew G; de Wit, Harriet; Jacob, Suma

    2016-12-01

    The neuropeptide oxytocin (OT) has received increased experimental attention for its putative role in both normal social functioning and several psychiatric disorders that are partially characterized by social dysfunction (e.g., autism spectrum disorders: ASD). Many human experimental studies measure circulating plasma levels of OT in order to examine the relationship between the hormone and behavior. Urinary OT (uOT) assays offer a simple, easy, and non-invasive method to measure peripheral hormone levels, but the correspondence between uOT and plasma OT (pOT) levels is unclear. Here, we conducted two within-subjects, double-blind studies exploring changes in uOT and pOT levels following administration of two drugs: MDMA, an oxytocin-releasing drug (Study 1), and intranasal oxytocin (INOT: Study 1 and 2). In Study 1, 14 adult participants (2 females) were each administered either oral 1.5mg/kg MDMA or 40IU INOT across two different study sessions. In Study 2, 10 male participants (adolescents and young adults) diagnosed with ASD received either 40IU INOT or placebo across two different sessions. In both studies, blood and urine samples were collected before and after drug administration at each study session. For Study 1, 10 participants provided valid plasma and urine samples for the MDMA session, and 8 provided valid samples for the INOT session. For Study 2, all 10 participants provided valid samples for both INOT and placebo sessions. Pre- and post-administration levels of pOT and uOT were compared. Additionally, correlations between percent change from baseline uOT and pOT levels were examined. Study 1: Plasma OT and uOT levels significantly increased after administration of MDMA and INOT. Furthermore, uOT levels were positively correlated with pOT levels following administration of MDMA (r=0.57, p=0.042) but not INOT (r=0.51, p=0.097). Study 2: There was a significant increase in uOT levels after administration of INOT, but not after administration of

  2. Testimonios arqueológicos del Oriente Próximo reflejados en el Séfer–Masa`ot de Benjamín de Tudela (Siria-Palestina, Mesopotamia y Egipto

    Directory of Open Access Journals (Sweden)

    Magdalena Nom de Déu, José Ramón

    2005-04-01

    Full Text Available Benjamín de Tudela (en hebreo Biniamín ben rabbí Yonah mi- Tudela es, sin duda, un navarro universal. Judío de la aljama tudelana, se ignora la fecha de su nacimiento (acaso hacia 1130. Hijo de rabino y viajero infatigable, sólo sabemos de este personaje lo poco que de él se menciona en su famoso Libro de Viajes o Séfer-masa`ot, fruto de sus vivas experiencias —las más de las veces directas— exquisitamente plasmadas en su relación de viaje, redactadas en hebreo. Conocedor del romance navarro vernáculo de la época, sabía hebreo - su lengua de instrucción y cultivo literario- y árabe, entendiendo acaso el griego y el latín.…

  3. Neivelti juhitav Bank St. Petersburg korraldas täiendava IPO / Hetlin Villak

    Index Scriptorium Estoniae

    Villak, Hetlin

    2007-01-01

    Bank Saint Petersburg müüs täiendava aktsiaemissiooni käigus 50,68 miljonit aktsiat hinnaga 58,37 krooni aktsia, panga esimehele Indrek Neiveltile kuulub nüüd üle 100 miljoni krooni väärtuses panga aktsiaid

  4. Estonia teater - helikindel ja sinine = Estonian National Opera - soundproof and blue / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2006-01-01

    Rahvusooperi Estonia maja teatritiiva interjööri renoveerimine. Sisekujundus: Juta Lember (kavandas ka uued valgustid), Aulo Padar (SAB Lember & Padar). Arhitekt Indrek Suigusaar (AB Pluss OÜ). Restaureerimistööd: KAR-Grupp. Projekt ja valmis 2005. Ill.: 8 värv. sisevaadet

  5. Viljandi sõudeelling = Viljandi Rowing Slipway / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2010-01-01

    Viljandis Ranna pst. 13 asuva sõudeellingu arhitektuursest lahendusest. Arhitektid Lauri Saar, Toomas Paaver, Indrek Järve (Paik Arhitektid OÜ), kaasautorid Jaak-Adam Looveer, Tõnu Laanemäe. Žürii liige Kalle Komissarov žürii hinnangust kultuurkapitali aastapreemiale esitatud ehitisele

  6. Naised käsu korras firmade juhatusse! Jah või ei? / Kairi Alt, Aveli Kippari, Karl Koort... [jt.

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastavad Columbus IT Partner Eesti AS personalijuht Kairi Alt, Stele ja Riveli omanik Aveli Kippari, AS Panaviatic'i turundusjuht Karl Koort, OÜ Tarkvara Tehnoloogia Arenduskeskuse tegevjuht Indrek Vainu, AS PricewaterhouseCoopers auditiosakonna direktor Eva Jansen, Kalev Chocolate Factory tootmisjuht Hardo Reinike

  7. Inimlikumat keskkonda otsima / Hendrik Lindepuu

    Index Scriptorium Estoniae

    Lindepuu, Hendrik, 1958-

    1986-01-01

    Mark Soosaare "Lasnamäe" ("Tallinnfilm", 1985), Andres Söödi "Exegi monumentum" ("Tallinnfilm", 1985), Heini Drui "Elu vanas linnas" ("Tallinnfilm", 1985), Indrek Kangru "Alevimaastikud" ("Eesti Telefilm", 1985) ja Mati Põldre "Väike-Õismäe - rõngaslinn" ("Eesti Telefilm", 1985)

  8. Briefe aus dem Morgenland - Otto Friedrich von Richters Forschungsreise in den Jahren 1814-1816 / Vladimir Sazonov

    Index Scriptorium Estoniae

    Sazonov, Vladimir, 1979-

    2013-01-01

    Arvustus: Briefe aus dem Morgenland - Otto Friedrich von Richters Forschungsreise in den Jahren 1814-1816, hrsg. von Indrek Jürjo, Sergei Stadnikov, Hamburger Beiträge zur Geschichte des östlichen Europa, Bd. 20. Hamburg: Verlag Dr. Kovač 2013, 313 lk.

  9. Pärnu jõgi - linna unustatud arengutelg = The Pärnu river - forgotten growth axis of the town / Rene Valner

    Index Scriptorium Estoniae

    Valner, René, 1972-

    2001-01-01

    Pärnu Linnavalitsuse ja Eesti Kunstiakadeemia korraldatud arhitektuuri ja kohamarketingi Riveside Workshop'ist 18.-28. VI 2001. a. Pärnus. Juhendajad: Viini arhitektuuribüroo Rataplan arhitektid Gerhard Huber ja Susanne Höhndorf, eesti arhitektid Siiri Vallner, Rene Valner ja Indrek Peil

  10. Surnud mehe käsi / Veiko Belials

    Index Scriptorium Estoniae

    Belials, Veiko, 1966-

    1997-01-01

    Arvustus: Asimov, Isaac. Asum / inglise k. tlk. Linda Ariva. Tallinn : Eesti Raamat, 1985. (Mirabilia); Asimov, Isaac. Asum ja impeerium / inglise k. tlk. Linda Ariva. Tallinn : Eesti Raamat, 1989. (Mirabilia); Asimov, Isaac. Teine asum / inglise k. tlk. Indrek Elling. Tallinn : Eesti Raamat, 1996. (Mirabilia)

  11. Männiku sotsiaalelamu = Social housing in Männiku / Peeter Pere

    Index Scriptorium Estoniae

    Pere, Peeter, 1957-

    2012-01-01

    2012. a. Tallinnas Männiku tee 92 valminud inva- ja peremajutamiseks mõeldud sotsiaalelamu, vana ühiselamu ümberprojekteerimine. Arhitektid: Siiri Vallner, Indrek Peil, Kaire Nõmm, kaasautorid: Ragnar Põllukivi, Andro Mänd, Kadri Klementi (Kavakava). Sisearhitekt Tarmo Piirmets (Pink). Projekt: 2010-2011

  12. Ilmaelu läbi irooniaprisma / Ragne Nukk

    Index Scriptorium Estoniae

    Nukk, Ragne, 1984-

    2010-01-01

    Kunstnikeduo Johnson ja Johnson (Taavi Talve, Indrek Köster) näitus "Nothing Left to Save" Draakoni galeriis 15. maini 2010. Näitus põhineb saksa režissööri Rainer Werner von Fassbinderi filmil "Petra von Kanti kibedad pisarad"

  13. Hea ja halb Baudelaire / Lauri Leesi

    Index Scriptorium Estoniae

    Leesi, Lauri, 1945-

    2000-01-01

    Arvustus: Baudelaire, Charles. Kurja lilled / koost. August Sang. Tallinn : Perioodika, 1967. (Loomingu Raamatukogu; 35-36) ; Baudelaire, Charles. Väikesed kurja lilled / koost. Indrek Hirv. Tln. : Tänapäev, 2000 ; Baudelaire, Charles. Kurja õied / tlk. Tõnu Õnnepalu. Tln. : Eesti Keele Sihtasutus, 2000

  14. Kruuda tahab Kalevi ja Tere ikkagi Altale müüa / Hindrek Riikoja

    Index Scriptorium Estoniae

    Riikoja, Hindrek

    2008-01-01

    Oliver Kruuda firmade Kalev ja Tere müügiläbirääkimiste katkemisest Altaga. Alta Capitali juhi Indrek Rahumaa sõnul loodetakse müügilepinguni jõuda aasta teises pooles. Lisa: Mille üle läbi räägiti

  15. Tuulelohe lend 2008 : Juhan Parts kutsus tööstureid arutelule

    Index Scriptorium Estoniae

    2008-01-01

    Kokkuvõte majandusfoorumist, kus arutati Eesti majanduspoliitika ja tööstuse tulevikku. Arutlevad majandus- ja kommunikatsiooniminister Juhan Parts, teadlane Endel Lippmaa, Eesti Telekomi juhatuse esimees Valdo Kalm, Eesti Arengufondi nõukogu esimees Indrek Neivelt ja AS-i Standard juhatuse esimees Enn Veskimägi

  16. Toomas Annus. Elu koos kapoga / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2007-01-01

    Merko suuromanik Toomas Annus räägib hirmuõhustikust ja kahtlustustest tema ümber, sõpradest ja toetajatest, süüdistusest ja prokuratuuri käitumisest. Vt. samas: Skandaal hakks kaks aastat tagasi. Kommenteerivad: Enn Veskimägi, Juhan Parts, Indrek Neivelt

  17. Täna õhtul kohtuvad Harju mäel tuli ja jää / Siiri Suutre

    Index Scriptorium Estoniae

    Suutre, Siiri

    2007-01-01

    Tallinna valgusfestivali raames toimub 10.02.2007 Harjumäel tule ja jää pidu. Korraldaja Indrek Leht. Tuleinstallatsiooni "Born to fly" autorid leedu kunstnikud Kestutis ja Vytautis Musteikis, jääskulpuuride autorid Tiiu Kirsipuu, Kalle Pruuden, Aime Kuulbusch ja Üllar Kallau

  18. TÜ Loodusmuuseum = University of Tartu Natural History Museum / Raili Paling, Liis Lindvere, Kadri Kaldam ; kommenteerinud Jana Lass

    Index Scriptorium Estoniae

    Paling, Raili

    2016-01-01

    Tartu Ülikooli Loodusmuuseumi (Tartu, Vanemuise tn. 46) interjöör ja ekspositsioon. Autorid Jelena Altmäe, Kadri Kaldam, Raivo Kotov, Andrus Kõresaar, Lea Laidra, Liis Lindvere, Indrek Mikk, Jaanus Männik, Raili Paling; projektijuht Reet Mägi; kuraatorid Kaie Kotov, Riste Keskpaik

  19. Lennusadam = Seaplane Harbour / Andrus Kõresaar

    Index Scriptorium Estoniae

    Kõresaar, Andrus, 1975-

    2013-01-01

    Tallinna Lennusadama vesilennukite angaaride rekonstrueerimisest, Eesti Meremuuseumi uue ekspositsiooni kujundusest. Autorid: Andrus Kõresaar, Olga Batuhtina, Raivo Kotov, Margit Argus, Margit Aule, Indrek Mikk (KOKO Arhitektid). Insener Karl Õiger. Arhitektuuriajaloolase Mart Kalmu ning arhitektuurikriitiku ja ESLi aastapreemiate žürii liikme Triin Ojari arvamused

  20. Eesti Kunstiakadeemia : tänavused lõpetajad

    Index Scriptorium Estoniae

    1999-01-01

    Lõpetajad 1999. a.: maalikunst (8), stsenograafia (4), graafika (8), skulptuur (3), keraamika (4), klaasikunst (4), metallikunst (3), tekstiil (4), moekunst (6), nahakunst (6), sisearhitektuur (7), graafiline disain (9), tootedisain (2), kunstiteadus (9). 1999. a. omandasid magistrikraadi Külliki Talp, Kaire Rannik, Indrek Allmann, Martin Melioranski.

  1. Laval askeldavad sümpaatne härra ja sulane, kes polegi rehepapp / Krista Valdvee

    Index Scriptorium Estoniae

    Valdvee, Krista, 1978-

    2009-01-01

    Ugala uuest suvelavastusest, Bertolt Brechti rahvatükist "Härra Punttila ja tema sulane Matti", mille kirjutamisel Bertolt Brecht tugines Hella Wuolijoe lugudele. Lavastaja Kalju Komissarov, mängitake Ugala tiigi kõrvale ehitatud laval. Osades: härra Punttila - Peeter Tammearu, Matti - Indrek Sammul

  2. On see realistlik - 400 ehitust kahe suvega ellu viia? / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2011-01-01

    CO₂ kvoodi müügist rahastatakse üle 400 objekti energiasäästlikumaks renoveerimist. Ehitusettevõtjate liidu tegevdirektori Indrek Petersoni hinnangul töö firmade taha ei jää, pigem nähakse probleemi hankeprotsesside korraldamises ning projekteerimishangete läbiviimises

  3. Targa Maja kompetentsikeskus Rakveres = Smart House Competence Centre in Rakvere / Oliver Alver

    Index Scriptorium Estoniae

    Alver, Oliver, 1977-

    2016-01-01

    Targa Maja kompetentsikeskus Rakveres, Lai tänav 20. Arhitektid Oliver Alver, Andres Alver, Indrek Rünkla, Tarmo Laht, Ott Alver, Sven Koppel, Ulla Saar (Alver Arhitektid). Sisearhitektid Jan Graps, Ken Ruut, Anne Määrmann (Jan&Ken OÜ). Kultuurkapitali Arhitektuuri sihtkapitali aastapreemia nominent 2016

  4. Bastion loobub oma kinnisvarast / Erik Müürsepp

    Index Scriptorium Estoniae

    Müürsepp, Erik

    2008-01-01

    Rõivatootja Bastion eraldab oma varadest kinnisvara ja kannab selle üle OÜ Bastion Kinnisvara omandisse. Omanik Indrek Stahli sõnul lähevad kinnisvara eraldamisega selgemaks tootmisettevõtte näitajad. Bastioni müük on kolme kvartaliga vähenenud vaid 5,8%

  5. Liivatonnidest sündis Tamula ääres skulptuuripark / Kaile Kabun

    Index Scriptorium Estoniae

    Kabun, Kaile

    2007-01-01

    Esimene liivakujude sümpoosion "Võru liivaliin 2007". Osavõtjaid viielt maalt: Kate Robinson Shotimaalt, Jan Fedorcak Tšehhist, Ruslan Korovkov Bulgaariast, Kazys Venclovas ja Juste Venclovaite Leedust ja Jaan Mass Eestist. Valminud töödest. Kommenteerib sümpoosioni juht Indrek Leht

  6. Results of a M = 5.3 heat transfer test of the integrated vehicle using phase-change paint techniques on the 0.0175-scale model 56-OTS in the NASA/Ames Research Center 3.5-foot hypersonic wind tunnel

    Science.gov (United States)

    Marroquin, J.

    1985-01-01

    An experimental investigation was performed in the NASA/Ames Research Center 3.5-foot Hypersonic Wind Tunnel to obtain supersonic heat-distribution data in areas between the orbiter and external tank using phase-change paint techniques. The tests used Novamide SSV Model 56-OTS in the first and second-stage ascent configurations. Data were obtained at a nominal Mach number of 5.3 and a Reynolds number per foot of 5 x 10 to the 6th power with angles of attack of 0 deg, +/- 5 deg, and sideslip angles of 0 deg and +/- 5 deg.

  7. A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.

    Science.gov (United States)

    Eliava, Marina; Melchior, Meggane; Knobloch-Bollmann, H Sophie; Wahis, Jérôme; da Silva Gouveia, Miriam; Tang, Yan; Ciobanu, Alexandru Cristian; Triana Del Rio, Rodrigo; Roth, Lena C; Althammer, Ferdinand; Chavant, Virginie; Goumon, Yannick; Gruber, Tim; Petit-Demoulière, Nathalie; Busnelli, Marta; Chini, Bice; Tan, Linette L; Mitre, Mariela; Froemke, Robert C; Chao, Moses V; Giese, Günter; Sprengel, Rolf; Kuner, Rohini; Poisbeau, Pierrick; Seeburg, Peter H; Stoop, Ron; Charlet, Alexandre; Grinevich, Valery

    2016-03-16

    Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord, but their function has not been directly assessed. Here, we identified a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord. Evoked OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain. Our findings identify a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Effect of oxytocin injection to milching buffaloes on its content & stability in milk

    Directory of Open Access Journals (Sweden)

    Raghu Pullakhandam

    2014-01-01

    Full Text Available Background & objectives: Oxytocin (OT injections to milch cattle for milk letdown have become a common practice amongst dairy farmers in India. Although there is no reported evidence, it is widely presumed that long term consumption of such milk leads to adverse health consequences. However, there is no information on the effect of exogenous OT injections on milk OT content and its stability during heating and gastrointestinal digestion. This study was carried out to determine the OT content in milk samples given by buffaloes with and without OT injections and to assess the stability of OT in the milk. Methods: Milk samples from milch buffaloes (Murrah buffalo were collected from local farmers with (n=121 or without (n=120 exogenous OT injections during 3 to 5 months of lactation period. The OT content of milk samples was estimated by competitive enzyme immunoassay (EIA. The thermal and digestive stability of OT was assessed by in silico and in vitro digestion methods. Results: The OT content of the milk samples was similar regardless of OT injections used. Further, OT was found to be stable to heat treatment and gastric pepsin digestion while it was rapidly digested during the simulated intestinal digestion. r0 educed OT was digested by pepsin, implying that internal disulphide bridge of OT rendered the peptide resistant to peptic digestion. On the other hand, phenylmethylsulphonyl fluoride (PMSF, a serine protease inhibitor, abrogated the pancreatin induced digestion of OT. Interpretation & conclusions: These findings suggest that exogenous OT injections do not influence its content in milk. Further, OT present in milk is rapidly degraded during intestinal digestion, ruling out its intestinal absorption and associated adverse health consequences, if any.

  9. Suured lood või tasane tuiklemine telepurgi suunas? / Karl Martin Sinijärv

    Index Scriptorium Estoniae

    Sinijärv, Karl Martin, 1971-

    2010-01-01

    Eesti kriminaalromaanidest: Hargla, Indrek. Apteeker Melchior ja Oleviste mõistatus. Tallinn : Varrak, 2010 ; Klaara ja Kaarel Kivi põnevikest "Mõrtsukatöö Faehlmanni tänavas" (2005), "Mõrvasügis" (2007), "Varandus seinal" (2008) ja "Ajakirjaniku surm" (2010). Kriminaalromaanide eelistest põnevusfilmide ja teleseriaalidega võrreldes

  10. Vähem formaalsust, rohkem julgust ja enesekriitikat! / Marko Mäetamm, Anneli Porri, Tiit Pääsuke ... [jt.] ; intervjueerinud Reet Varblane

    Index Scriptorium Estoniae

    2009-01-01

    Kunstiõpetamise võimalikkuse ja vajalikkuse üle vestlesid Eesti Kunstiakadeemia vabade kunstide teaduskonna dekaan Marko Mäetamm, fotokunsti osakonna õppejõud Anneli Porri, emeriitprofessor Tiit Pääsuke, prorektor Liina Siib, graafilise disaini osakonna õppejõud Indrek Sirkel ja ehtekunsti osakonna õppejõud Tanel Veenre

  11. Elav kaart viib Margi ja Ahase Veneetsiasse

    Index Scriptorium Estoniae

    2006-01-01

    Komisjon (liikmed loetletud) valis Veneetsia X arhitektuuribiennaalil "Meta-linn" Eestit esindama sotsiaalse positsioneerimise meetodi. Väljapaneku loovad AB Urban Mark (arhitektid Ülar Mark, Kaja Pae, Indrek Tiigi) ja Tartu Ülikooli geograafia instituut (teadurid Rein Ahas, Anto Aasa, Siiri Silm). Avalikule ideekonkursile laekus 9 projekti

  12. Moblaga Veneetsiasse! / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2006-01-01

    Veneetsia X arhitektuuribiennaalil esindab Eestit arhitektuuribüroo Urban Mark (arhitektid Ülar Mark, Kaja Pae, Indrek Tiigi) ja Tartu Ülikooli Geograafia Instituudi (teadurid Rein Ahas, Anto Aasa, Siiri Silm) projekt. Kommenteerib Ülar Mark. Lühidalt ka teistest eestisisesel konkursil osalenud töödest

  13. Kuhu edasi, härra Rahumaa? / Sulev Vedler

    Index Scriptorium Estoniae

    Vedler, Sulev, 1970-

    2008-01-01

    Riskikapitalifirma Alta Capital omanikud peavad lähema poole aasta jooksul lunastama võlakirju kokku üle poole miljardi krooni ulatuses. Indrek Rahumaa sõnul võlakirjadega probleeme ei teki. Autor leiab, et Alta Capital on muutumas ning ta esitab oma arvamuse tõestuseks viis argumenti

  14. Koputajate kaitseks! / Ivar Tallo

    Index Scriptorium Estoniae

    Tallo, Ivar, 1964-

    2003-01-01

    Politoloog Ivar Tallo arvates võiks Riigikogu välja tulla initsiatiiviga luua ühiskonna esindajate osavõtul vigade ja pettuste paljastajate kaitse seadus. Küsimusele, kust läheb politseiametniku sõnavabaduse piir vastavad Ain Seppik, Tarmo Loodus ja Jaanus Rahumägi. Indrek Sirgi juhtum

  15. Tallinna Teletorn = Tallinn Television Tower

    Index Scriptorium Estoniae

    2015-01-01

    Rekonstrueeritud Tallinna Teletorn Kloostrimetsa tee 58a, valminud 2012. Eesti kultuurkapitali aastapreemia 2012. Arhitekt David Basiladze. Rekonstrueerimise projekti arhitektid Raivo Kotov, Andrus Kõresaar, Indrek Mikk, Margit Aule, Jaanus Männik, Lea Laidra, Karis Kahr (KOKO Arhitektid). Sisearhitektid Liis Lindvere, Raili Paling, Margit Argus (KOKO Arhitektid). Konstruktor Neoprojekt

  16. Uus Sakala arhitektuurivõistlus = The Uus Sakala architectural competition / Panu Lehtovuori

    Index Scriptorium Estoniae

    Lehtovuori, Panu, 1968-

    2003-01-01

    Žürii liige konkursist: keskuse asukohast ja programmist, praeguse Sakala keskuse kasutamisest, konkursi tulemusest. Teise vooru valiti kolm projekti: võidutöö "Küpsis" (autorid Toomas Tammis, Inga Raukas, Tarmo Teedumäe, ArhitektuuriAgentuur), "Ocularis" (autorid Siiri Vallner, Indrek Peil), "Sõstrad" (autor Veronika Valk)

  17. Köök - meelte ateljee / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2008-01-01

    2008. a. valminud õppeköögist "Köök" Tallinnas Pikk t. 42. Sisekujundus: Indrek Kasela, Sikke Sumari (omanikud). Paekivi- ja punasetest tellistest seintega ruumi kaunistab moodne kunst. Skulpturaalse veini- ja raamaturiiuli on kavandanud Edith Karlson ja Flo Kasearu, lühtri autor on Anna Roomet

  18. Narvski kolledzh ostanetsja bez utshebnogo korpusa?

    Index Scriptorium Estoniae

    2007-01-01

    TÜ Narva kolledzh andis 2007. a. jaanuaris kohtusse Narva linna, sest viimane keeldub Raekoja platsile planeeritavale kolledzhi uuele õppehoonele ehitusluba väljastamast. 2005. a. avaliku arhitektuurikonkursi võitnud arhitektide Siiri Vallneri, Indrek Peili ja Katrin Koovi projekt "Vihm" on saanud heakskiidu riiklikus muinsuskaitsenõukogus ja -ametis

  19. Äkki polnud see Noole viimane kümnevõistlus? / Tarmo Paju

    Index Scriptorium Estoniae

    Paju, Tarmo

    2004-01-01

    Erki Nool jäi kümnevõistluses 8. kohale, andes samas mõista, et tema kümnevõistleja karjäär ei pruugi veel lõppenud olla. Indrek Turi lõpetas 23. kohaga. Eesti fännid andsid Noolele kõrge hinde

  20. Nimetage mõned suuremad nõmedused, mida üks ülemus teha saab? / Kairi Ütsmüts, Allan Rosenberg, Katriin Jüriska ... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad Swedbank Eesti infotehnoloogia projektijuht Kairi Ütsmüts, Aspiro Eesti müügijuht Allan Rosenberg, Uuskasutuskeskuse tegevjuht Katriin Jüriska, Tele2 toote- ja turundusjuht Reilika Ilp, GrabCAD'i omanik ja insener Indrek Narusk ning turismifirma Estfly omanik Vahur Mäe

  1. SISU sümpoosioni mõttekoda: sisearhitekti identiteet ja ruumiline keskkond

    Index Scriptorium Estoniae

    2015-01-01

    Tüüne-Kristin Vaikla, Eero Jürgenson, Peeter Päll, Kalle Vellevoog, Urmo Vaikla, Hannes Praks, Yoko Alender, Urmas Pastarus, Triin Ojari, Taevo Gans, Indrek Allmann, Martin Samm ja Terje Kivist arutlevad ümarlauas sisearhitekti identiteedi, ehitatava keskkonna ning erialaliitude võimaliku ühinemise teemadel

  2. Tartu ja Tallinna boheemkond ning lotovõitjad : Valitud palu dokumentaalfilmide sarjast "Eesti lood" / Olev Remsu

    Index Scriptorium Estoniae

    Remsu, Olev, 1947-

    2009-01-01

    ETVs näidatud dokumentaalfilmidest sarjas "Eesti lood" - Indrek Kangro film Jaan-Jürgen Klausist "Professionaalne amatöör" (eetris 3. XII 2008), Margit Lillaku film kunstnik Sandra Jõgevast "Ars longa" (eetris 29. X 2008), Eva-Katariina Taimre "Jackpot" lotovõitjatest (eetris 19. XI 2008)

  3. Piiripealne privaatsus : ridaelamu Esku tänaval Tallinnas = Bordeline Privacy : Row-House on Esku Street in Tallinn / Emil Urbel ; üles. kirjut. Triin Ojari

    Index Scriptorium Estoniae

    Urbel, Emil, 1959-

    2004-01-01

    Tüüpmajast, eramajade ise-projekteerimisest ja -ehitamisest, 12-kortelisest puitlaudisega ridaelamust, privaatsuse piiridest. Ridaelamu projekteerija: AB Emil Urbel. Arhitektid Emil Urbel ja Indrek Erm, konstruktor Tõnu Peipman. Projekt 2003, valmis 2004. Ill.: I, II ja III korruse plaan, 6 värv. välisvaadet.

  4. Lotte lasteaed : Ida 8, Tartu = Lotte Nursery School : Ida 8, Tartu / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2009-01-01

    Lasteaiast, mille arhitektid on Indrek Peil ja Siiri Vallner (pälvisid riigi kultuuripreemia, Kavakava), sisearhitektid Tea Tammelaan, Malle Jürgenson, Krista Lepland (pälvisid EK arhitektuuri sihtkapitali aastapreemia 2008) ja Sirli Ehari (Laika, Belka & Strelka), maastikuarhitekt Anna-Liisa Unt. Žürii hinnang lasteaiale

  5. Navodnenija v umah zactroishtshikov / Maris Kuuda

    Index Scriptorium Estoniae

    Kuuda, Maris

    2007-01-01

    Kohalikel omavalitsustel pole piisavalt hoobasid sundida arendajaid üleujutusohuga arvestama. Pärnusse hotelli September rajajad (arhitektid Emil Urbel, Andrus Mark) arvestavad ujutusohuga. Arvamust avaldavad Rene Reisner, Mari Sepp, Ülo Sults, Karri Tiigisoon, Indrek Rannik, Mark Soosaar, Tiiu Pärn, Merle Looring, Rita Sepp, Kaspar Alles

  6. Vikergallup : Eesti kirjandus 2006

    Index Scriptorium Estoniae

    2007-01-01

    19 arvustaja vastus küsimusele, milline oli 2006. aasta parim uudisraamat ja debüütteos. Ära nimetati Hasso Krulli luulekogu "Talv", Jan Kausi romaan "Tema", Madis Kõivu "Näidendid I", Jaan Pehki luulekogu "Tuigu kui tuled", Tarmo Tedre romaan "Onanistid", Kristiina Ehini romaan "Pillipuhujanaine ja pommipanijanaine", Marko Kompuse luulekogu "Vallaliste jõgede tõkkejooksja", Mathura luulekogu "Kohalolu", Rein Põdra romaan "Eike", Indrek Ryytle luulekogu "Inglid rokijaamas", Triin Soometsa "Väljas" ja Ervin Õunapuu romaan "Meie igapäevane jää". Debüütteostest mainiti Kaupo Meieli luulekogu "Polügrafisti käsiraamat", Anti Saare romaani "Kuidas sa ära läksid ja mina maha jäin", Andra Teede luulekogu "Takso Tallinna taevas", Maarja Kangro luulekogu "Kurat õrnal lumel", Andrus Elbingu luulekogu "Siin Beebilõust, tere!", Tiina Ilvese juturaamat "Augustihambad", Indrek Koffi luulekogu "Vana laul", Eliina Kortsu luulekogu "Lööklaused murravad metsi", Carolina Pihelga luulekogu "Sõrmemuster" ja Paavo Piigi luulekogu "Kummuli linnad"

  7. Kaitsealane abikäepoliitika / Indrek Sirp

    Index Scriptorium Estoniae

    Sirp, Indrek

    2008-01-01

    Eesti kaitsealase abikäepoliitika põhieesmärk on NATO ja Euroopa Liidu naabruskonnas stabiilse julgeolekukeskkonna tagamine ning demokraatlike riikide vööndi laiendamine. Eesti kaitseabi neli prioriteetset sihtriiki on Afganistan, Gruusia, Montenegro ja Ukraina. Autor annab ülevaate abikäepoliitikast

  8. Johann Georg Eisen / Indrek Jürjo

    Index Scriptorium Estoniae

    Jürjo, Indrek, 1956-2009

    1999-01-01

    Rets. rmt.: Johann Georg Eisen (1717-1779). Ausgewählte Schriften. Deutsche Volksaufklärung und Leibeigenschaft im Russischen Reich. Hrsg. von Roger Bartlett und Erich Donnert. Marburg : IHerder-Institut, 1998

  9. Teater Varius & Co / Indrek G. Sarapuu

    Index Scriptorium Estoniae

    Sarapuu, Indrek G.

    1999-01-01

    Jazz-draama "Põud" Varius Teatri esituses, dramatiseerija ja lavastaja Heidi Sarapuu, muusika Villu Veski ansamblilt, tants Renee Nõmmikult, peaosas Haide Männamaa. Draama käsitleb taani kirjaniku Karen Blixeni elu Aafrika-perioodi. Esietend. 26. aprillil

  10. Side- ja turvanguamet / Indrek Süld

    Index Scriptorium Estoniae

    Süld, Indrek

    2004-01-01

    Ilmunud ka: 2003 : annual report : [Eesti Raudtee]. - Tallinn, 2004, lk. 34-35; 2003 : godovoi ottshjot : [Eesti Raudtee]. - Tallinn, 2004, lk. 34-35. Ülevaade AS-i Eesti Raudtee side- ja turvanguameti tegevusest 2003. aastal. Skeem

  11. Akraasia ja Davidson / Indrek Männiste

    Index Scriptorium Estoniae

    Männiste, Indrek

    2005-01-01

    Akraasia - olukord, kus pidades paremaks mingit üht toimimisviisi, tegutsetakse ikkagi vastupidiselt (nät. suitsetamine, joomine jms.). Akraasiaprobleemi sisu on vastuolu inimpraktika ja teooria vahel. Artiklis antakse ülevaade akraasiakäsitlustest läbi aegade ja kaasaegse akraasiadiskursuse esindaja Donald Davidsoni argumentatsioonist

  12. Kas loodus + foto = loodusfoto? / Indrek Rohtmets

    Index Scriptorium Estoniae

    Rohtmets, Indrek, 1953-

    2006-01-01

    Rahvusvaheline fotokonkursi näitus "Loodusfoto 2005" Kumus kuni 12. XI. Loodusfotograafiast, Shell Wildlife Photographer of the Year võistlusest. Peapreemia pälvis 2005. a. Manuel Presti, 2006. a. Göran Ehlme. Eric Hoskingi auhinna sai 2005. a. Bence Mate

  13. Tallinna kultuurivabrik / Indrek Peil, Rene Valner

    Index Scriptorium Estoniae

    Peil, Indrek, 1973-

    2000-01-01

    Arhitektuuriworkshop "Symbiosis factory" 6.-10. I 2000 Tallinna Tselluloosikombinaadis. Osalesid Eesti Kunstiakadeemia arhitektuuritudengid ja arhitektid büroodest Kolm Pluss Üks, Alver Trummal Arhitektid, Arhitektuuriagentuur, COO Arhitektid, Mark & Tamm. 13 ill

  14. Effect of different doses of oxytocin on cardiac electrophysiology and arrhythmias induced by ischemia.

    Science.gov (United States)

    Houshmand, Fariba; Faghihi, Mahdieh; Imani, Alireza; Kheiri, Soleiman

    2017-01-01

    The onset of acute myocardial ischemia (MI) is accompanied by a rapid increase in electrical instability and often fatal ventricular arrhythmias. This study investigated that whether oxytocin (OT) can modulate ischemia-induced arrhythmias and considered relationships between the severity of arrhythmia and the electrocardiogram parameters during ischemia. OT (0.0001-1 μg) was administrated intraperitoneally 30 min before ischemia. To examine receptor involved, a selective OT-receptor antagonist, atosiban (ATO), was infused 10 min before OT. OT caused a significant and biphasic dose-dependent reduction in ectopic heart activity and arrhythmia score. OT doses that reduced ventricular arrhythmia elicited significant increase in QT interval. OT attenuated the electrophysiological changes associated with MI and there was significant direct relationship between QRS duration and arrhythmia score. ATO treatment reduced beneficial effects of OT on arrhythmogenesis. Nevertheless, ATO failed to alter OT effects on premature ventricular contractions. We assume that the ability of OT to modulate the electrical activity of the heart may play an important role in the antiarrhythmic actions of OT.

  15. Effect of different doses of oxytocin on cardiac electrophysiology and arrhythmias induced by ischemia

    Directory of Open Access Journals (Sweden)

    Fariba Houshmand

    2017-01-01

    Full Text Available The onset of acute myocardial ischemia (MI is accompanied by a rapid increase in electrical instability and often fatal ventricular arrhythmias. This study investigated that whether oxytocin (OT can modulate ischemia-induced arrhythmias and considered relationships between the severity of arrhythmia and the electrocardiogram parameters during ischemia. OT (0.0001–1 μg was administrated intraperitoneally 30 min before ischemia. To examine receptor involved, a selective OT-receptor antagonist, atosiban (ATO, was infused 10 min before OT. OT caused a significant and biphasic dose-dependent reduction in ectopic heart activity and arrhythmia score. OT doses that reduced ventricular arrhythmia elicited significant increase in QT interval. OT attenuated the electrophysiological changes associated with MI and there was significant direct relationship between QRS duration and arrhythmia score. ATO treatment reduced beneficial effects of OT on arrhythmogenesis. Nevertheless, ATO failed to alter OT effects on premature ventricular contractions. We assume that the ability of OT to modulate the electrical activity of the heart may play an important role in the antiarrhythmic actions of OT.

  16. 'Deani masin' ja teisi raamatuid / [Seppel, Aarne] Led Seppel

    Index Scriptorium Estoniae

    Seppel, Led, pseud., 1974-

    1996-01-01

    Rets rmt.: Kassett 1995 / Koost. Elo Vee. Tln. : Eesti Raamat, 1996.Sisu: Kätlin Kätlin. Larii-laree; Kuningas, Madis-Mats. Sõna täüs aiga; Alt, Mai. Laule härjapõlvlase päevaraamatust; A. C. Homseni; Zipp, Lemme. Kirja pandud paberile; Ryytle, Indrek. Deani masin

  17. UNESCO otsustab vanalinna saatuse kahe aasta pärast / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2006-01-01

    Tallinna külastanud UNESCO maailmapärandi komitee esindaja professor Giorgio Piccinato hoiatab linnavõime, et uute kõrghoonete ehitamine kesklinna ja Skoone bastioni erastamine võib kaasa tuua Tallinna vanalinna maailmapärandi nimistust väljaarvamise. Intervjuu Piccinatoga. Kommentaarid Jaan Tammelt, Indrek Toomelt, Yrjo Vanhanenilt

  18. Alta peab tasuma Kalevile mais / Kersti Saar

    Index Scriptorium Estoniae

    Saar, Kersti

    2008-01-01

    Indrek Rahumaa juhitav Alta Capital peab tasuma Oliver Kruudale Kalevi tütarfirmade eest 660 miljonit krooni hiljemalt 30. maiks. Vt. samas: Investorid teavad tehingu hinda ja lõplikku tähtaega. Diagramm: Kalevi turuväärtus jääb Alta müügihinnale alla

  19. Vargamäelt leigust ei leitud / Jan Kaus

    Index Scriptorium Estoniae

    Kaus, Jan, 1971-

    2008-01-01

    Vargamäel 21. juunil 22 tundi kestnud maratonetendusest Tammsaare "Tõe ja õiguse" põhjal - Elmo Nüganeni lavastused "Tõde ja õigus. Teine osa", "Karin. Indrek. Tõde ja õigus. 4" ja "Wargamäe Wabariik" (III osa) ning Jaanus Rohumaa lavastus "Vargamäe kuningriik" (I ja V osa)

  20. Emerging Identities - EAST! / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2007-01-01

    21. 11. 2007-17. 02. 2008 on Soome Arhitektuurimuuseumis avatud näitus Ida-Euroopa (Berliin, Bratislava, Budapest, Ljubljana, Praha, Riia, Tallinn, Vilnius, Varssavi) noorest arhitektuurist. Näituse esmaesitlus koos kataloogiga (Eesti eessõna Siiri Vallnerilt ja Indrek Peililt) oli 2005. a. Berliinis. Näituse koostaja Kristien Ring

  1. Tool sai veerandi Silvanost võla katteks / Hannes Sarv

    Index Scriptorium Estoniae

    Sarv, Hannes

    2010-01-01

    Indrek Rahumaa on väidetavalt võtnud Toomas Tooli ja Stephan David Balkini käest laenu, pantides Silvano Fashion Group aktsiaid. 31. detsembril andis ettevõte börsile teateid selle kohta, et Toomas Tool omab Silvano Fashion Groupi aktsiatest 24,52% ja Stephan David Balkin - 20%

  2. Identification of a novel amino acid racemase from a hyperthermophilic archaeon Pyrococcus horikoshii OT-3 induced by D-amino acids.

    Science.gov (United States)

    Kawakami, Ryushi; Ohmori, Taketo; Sakuraba, Haruhiko; Ohshima, Toshihisa

    2015-08-01

    To date, there have been few reports analyzing the amino acid requirement for growth of hyperthermophilic archaea. We here found that the hyperthermophilic archaeon Pyrococcus horikoshii OT-3 requires Thr, Leu, Val, Phe, Tyr, Trp, His and Arg in the medium for growth, and shows slow growth in medium lacking Met or Ile. This largely corresponds to the presence, or absence, of genes related to amino acid biosynthesis in its genome, though there are exceptions. The amino acid requirements were dramatically lost by addition of D-isomers of Met, Leu, Val, allo-Ile, Phe, Tyr, Trp and Arg. Tracer analysis using (14)C-labeled D-Trp showed that D-Trp in the medium was used as a protein component in the cells, suggesting the presence of D-amino acid metabolic enzymes. Pyridoxal 5'-phosphate (PLP)-dependent racemase activity toward Met, Leu and Phe was detected in crude extract of P. horikoshii and was enhanced in cells grown in the medium supplemented with D-amino acids, especially D-allo-Ile. The gene encoding the racemase was narrowed down to one open reading frame on the basis of enzyme purification from P. horikoshii cells, and the recombinant enzyme exhibited PLP-dependent racemase activity toward several amino acids, including Met, Leu and Phe, but not Pro, Asp or Glu. This is the first report showing the presence in a hyperthermophilic archaeon of a PLP-dependent amino acid racemase with broad substrate specificity that is likely responsible for utilization of D-amino acids for growth.

  3. Bērnu mārketinga attīstība Latvijas lielāko pārtikas produktu ražotāju tirgus darbībās

    OpenAIRE

    Lūse, Ieva

    2010-01-01

    Uzņēmumi visā pasaulē arvien vairāk sāka apzināties bērnu potenciālu tirgū un aktivizē savu komunikāciju ar bērnu auditoriju. Bērni vienlaicīgi tirgū pilda vairākas lomas kā patērētāji, iniciatori, ietekmētāji un lēmēji par pirkumu un pircēji šodien un nākotnē, kļūstot par daudzu uzņēmumu produkcijas pamata patērētājiem. Ņemot vērā tēmas aktualitāti autore par maģistra darba mērķi izvirza apzināt un analizēt lielāko Latvijas pārtikas produktu ražotāju aktivitāti bērnu mārketing...

  4. Oxytocin and vasopressin flatten dominance hierarchy and enhance behavioral synchrony in part via anterior cingulate cortex.

    Science.gov (United States)

    Jiang, Yaoguang; Platt, Michael L

    2018-05-29

    The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) influence social functions in many mammals. In humans and rhesus macaques, OT delivered intranasally can promote prosocial behavior in certain contexts. Yet the precise neural mechanisms mediating these behavioral effects remain unclear. Here we show that treating a group of male macaque monkeys intranasally with aerosolized OT relaxes their spontaneous social interactions with other monkeys. OT reduces differences in social behavior between dominant and subordinate monkeys, thereby flattening the status hierarchy. OT also increases behavioral synchrony within a pair. Intranasal delivery of aerosolized AVP reproduces the effects of OT with greater efficacy. Remarkably, all behavioral effects are replicated when OT or AVP is injected focally into the anterior cingulate gyrus (ACCg), a brain area linked to empathy and other-regarding behavior. ACCg lacks OT receptors but is rich in AVP receptors, suggesting exogenous OT may shape social behavior, in part, via nonspecific binding. Notably, OT and AVP alter behaviors of both the treated monkey and his untreated partner, consistent with enhanced feedback through reciprocal social interactions. These findings bear important implications for use of OT in both basic research and as a therapy for social impairments in neurodevelopmental disorders.

  5. Modifications to the restriction method of Gentry and Casanas for otariid pups Modificaciones al método de restricción de Gentry y Casanas para crías de otáridos

    Directory of Open Access Journals (Sweden)

    Janitzio Égido-Villarreal

    2007-06-01

    Full Text Available To avoid risky and expensive chemical immobilization of otariid pups, physical restriction is a better option. For this reason we constructed a stretcher that permits wide liberty to interact with the pup and take a variety of samples in a safe, comfortable and easy way, for both the pup and the researcher.Para evitar el uso de la riesgosa y cara restricción química en crías de otáridos la mejor opción es la restricción física. Por lo anterior construimos una camilla que permite amplia libertad para la toma de diferentes tipos de muestras de manera segura, cómoda y fácil tanto para la cría como para el investigador.

  6. Body composition, metabolism, sleep, psychological and eating patterns of overtraining syndrome: Results of the EROS study (EROS-PROFILE).

    Science.gov (United States)

    Cadegiani, Flavio A; Kater, Claudio E

    2018-08-01

    Overtraining syndrome (OTS) is caused by an imbalance between training, nutrition and resting, and leads to decreased performance and fatigue; however, the precise underlying triggers of OTS remain unclear. This study investigated the body composition, metabolism, eating, sleeping patterns and mood states among participants with OTS. Selected participants were divided into OTS-affected athletes (OTS, n = 14), healthy athletes (ATL, n = 25), and healthy non-physically active controls (NCS, n = 12). Compared to ATL, OTS showed decreased sleep quality (p = 0.004); increased duration of work or study (p sleep, and increased cognitive activity are likely OTS triggers. OTS appears to induce dehydration, increase body fat, decrease libido, and worsen mood.

  7. Oxytocin in the prelimbic medial prefrontal cortex reduces anxiety-like behavior in female and male rats.

    Science.gov (United States)

    Sabihi, Sara; Durosko, Nicole E; Dong, Shirley M; Leuner, Benedetta

    2014-07-01

    The neuropeptide oxytocin (OT) is anxiolytic in rodents and humans. However, the specific brain regions where OT acts to regulate anxiety requires further investigation. The medial prefrontal cortex (mPFC) has been shown to play a role in the modulation of anxiety-related behavior. In addition, the mPFC contains OT-sensitive neurons, expresses OT receptors, and receives long range axonal projections from OT-producing neurons in the hypothalamus, suggesting that the mPFC may be a target where OT acts to diminish anxiety. To investigate this possibility, female rats were administered OT bilaterally into the prelimbic (PL) region of the mPFC and anxiety-like behavior assessed. In addition, to determine if the effects of OT on anxiety-like behavior are sex dependent and to evaluate the specificity of OT, male and female anxiety-like behavior was tested following delivery of either OT or the closely related neuropeptide arginine vasopressin (AVP) into the PL mPFC. Finally, the importance of endogenous OT in the regulation of anxiety-like behavior was examined in male and female rats that received PL infusions of an OT receptor antagonist (OTR-A). Overall, even though males and females showed some differences in their baseline levels of anxiety-like behavior, OT in the PL region of the mPFC decreased anxiety regardless of sex. In contrast, neither AVP nor an OTR-A affected anxiety-like behavior in males or females. Together, these findings suggest that although endogenous OT in the PL region of the mPFC does not influence anxiety, the PL mPFC is a site where exogenous OT may act to attenuate anxiety-related behavior independent of sex. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Sex-Specific Effects of Stress on Oxytocin Neurons Correspond With Responses to Intranasal Oxytocin.

    Science.gov (United States)

    Steinman, Michael Q; Duque-Wilckens, Natalia; Greenberg, Gian D; Hao, Rebecca; Campi, Katharine L; Laredo, Sarah A; Laman-Maharg, Abigail; Manning, Claire E; Doig, Ian E; Lopez, Eduardo M; Walch, Keenan; Bales, Karen L; Trainor, Brian C

    2016-09-01

    Oxytocin (OT) is considered to be a stress-buffering hormone, dampening the physiologic effects of stress. However, OT can also be anxiogenic. We examined acute and long-lasting effects of social defeat on OT neurons in male and female California mice. We used immunohistochemistry for OT and c-fos cells to examine OT neuron activity immediately after defeat (n = 6-9) and 2 weeks (n = 6-9) and 10 weeks (n = 4-5) later. We quantified Oxt messenger RNA with quantitative polymerase chain reaction (n = 5-9). Intranasal OT was administered to naïve and stressed mice tested in social interaction and resident-intruder tests (n = 8-14). Acute exposure to a third episode of defeat increased OT/c-fos colocalizations in the paraventricular nucleus of both sexes. In the medioventral bed nucleus of the stria terminalis, defeat increased Oxt messenger RNA, total OT neurons, and OT/c-fos colocalizations in female mice but not male mice. Intranasal OT failed to reverse stress-induced social withdrawal in female mice and reduced social interaction behavior in female mice naïve to defeat. In contrast, intranasal OT increased social interaction in stressed male mice and reduced freezing in the resident-intruder test. Social defeat induces long-lasting increases in OT production and OT/c-fos cells in the medioventral bed nucleus of the stria terminalis of female mice but not male mice. Intranasal OT largely reversed the effects of stress on behavior in male mice, but effects were mixed in female mice. These results suggest that changes in OT-sensitive networks contribute to sex differences in behavioral responses to stress. Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  9. Cigarette smoke inhalation increases the alveolar bone loss caused by primary occlusal trauma in a rat model.

    Science.gov (United States)

    Campos, M L G; Corrêa, M G; Júnior, F H N; Casati, M Z; Sallum, E A; Sallum, A W

    2014-04-01

    Occlusal trauma (OT) and smoking are both factors that alter alveolar bone metabolism and therefore could synergistically act on alveolar bone loss. The aim of this experimental study was to evaluate the influence of short-term cigarette smoke inhalation (CSI) on inter-radicular alveolar bone loss promoted by primary OT in a rat model. Forty-eight animals were randomly assigned to one of three groups based on treatment type: OT + CSI (n = 16), animals were exposed to CSI three times per day, for 8 min per exposure, and they concomitantly received unilateral vertical augmentation creating an occlusal interference inducing experimental OT; OT (n = 16), animals received only unilateral vertical augmentation; negative control (NC; n = 16), animals maintained for equal periods to achieve periodontal baseline values of periodontal ligament dimension. Each group was divided into two subgroups (n = 8) based on treatment length: 7 or 14 d. After 7 d, the OT + CSI group exhibited significantly higher bone loss compared to the NC group (p = 0.0022). After 14 d, the OT (p < 0.0001) and OT + CSI (p < 0.0001) groups presented significantly higher bone loss compared to the NC group, and OT + CSI resulted in significantly higher bone loss than OT alone (p = 0.0241). The number of tartrate-resistant acid phosphatase-positive cells on the linear surface of the bone crest after 7 d was significantly higher in the OT + CSI group as compared to the NC and OT groups (p < 0.0001 and p = 0.0045, respectively) and remained significantly higher in the OT + CSI group after 14 d, compared to the OT group (p < 0.0001). Short-term CSI increases early bone loss in association with OT after 7 d, and this worsens in severity after 14 d of exposure. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Oxytocin and Estrogen Receptor β in the Brain: An Overview.

    Science.gov (United States)

    Acevedo-Rodriguez, Alexandra; Mani, Shaila K; Handa, Robert J

    2015-01-01

    Oxytocin (OT) is a neuropeptide synthesized primarily by neurons of the paraventricular and supraoptic nuclei of the hypothalamus. These neurons have axons that project into the posterior pituitary and release OT into the bloodstream to promote labor and lactation; however, OT neurons also project to other brain areas where it plays a role in numerous brain functions. OT binds to the widely expressed OT receptor (OTR), and, in doing so, it regulates homeostatic processes, social recognition, and fear conditioning. In addition to these functions, OT decreases neuroendocrine stress signaling and anxiety-related and depression-like behaviors. Steroid hormones differentially modulate stress responses and alter OTR expression. In particular, estrogen receptor β activation has been found to both reduce anxiety-related behaviors and increase OT peptide transcription, suggesting a role for OT in this estrogen receptor β-mediated anxiolytic effect. Further research is needed to identify modulators of OT signaling and the pathways utilized and to elucidate molecular mechanisms controlling OT expression to allow better therapeutic manipulations of this system in patient populations.

  11. Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders

    Directory of Open Access Journals (Sweden)

    Valery eGrinevich

    2015-01-01

    Full Text Available Oxytocin (OT, the main neuropeptide of sociality, is expressed in neurons exclusively localized in the hypothalamus. During the last decade, a plethora of neuroendocrine, metabolic, autonomic and behavioral effects of OT has been reported. In the urgency to find treatments to syndromes as invalidating as autism, many clinical trials have been launched in which OT is administered to patients, including adolescents and children. However, the impact of OT on the developing brain and in particular on the embryonic and early postnatal maturation of OT neurons, has been only poorly investigated. In the present review we summarize available (although limited literature on general features of ontogenetic transformation of the OT system, including determination, migration and differentiation of OT neurons. Next, we discuss trajectories of OT receptors (OTR in perinatal period. Furthermore, we provide evidence that early alterations, from birth, in the central OT system lead to severe neurodevelopmental diseases such as feeding deficit in infancy and severe defects in social behavior in adulthood, as described in Prader-Willi syndrome. Our review intends to propose a hypothesis about developmental dynamics of central OT pathways, which are essential for survival right after birth and for the acquisition of social skills later on. A better understanding of the embryonic and early postnatal maturation of the OT system may lead to better OT-based treatments in Prader-Willi syndrome and autism.

  12. Operating theatre ventilation systems and microbial air contamination in total joint replacement surgery: results of the GISIO-ISChIA study.

    Science.gov (United States)

    Agodi, A; Auxilia, F; Barchitta, M; Cristina, M L; D'Alessandro, D; Mura, I; Nobile, M; Pasquarella, C

    2015-07-01

    Recent studies have shown a higher rate of surgical site infections in hip prosthesis implantation using unidirectional airflow ventilation compared with turbulent ventilation. However, these studies did not measure the air microbial quality of operating theatres (OTs), and assumed it to be compliant with the recommended standards for this ventilation technique. To evaluate airborne microbial contamination in OTs during hip and knee replacement surgery, and compare the findings with values recommended for joint replacement surgery. Air samplings were performed in 28 OTs supplied with unidirectional, turbulent and mixed airflow ventilation. Samples were collected using passive sampling to determine the index of microbial air contamination (IMA). Active sampling was also performed in some of the OTs. The average number of people in the OT and the number of door openings during the sampling period were recorded. In total, 1228 elective prosthesis procedures (60.1% hip and 39.9% knee) were included in this study. Of passive samplings performed during surgical activity in unidirectional airflow ventilation OTs (U-OTs) and mixed airflow OTs (M-OTs), 58.9% and 87.6% had IMA values >2, respectively. Of samplings performed during surgical activity in turbulent airflow OTs (T-OTs) and in turbulent airflow OTs with the surgical team wearing Steri-Shield Turbo Helmets (TH-OTs), 8.6% and 60% had IMA values ≤ 2, respectively. Positive correlation was found between IMA values and the number of people in the OT and the number of door openings (P systems always provide acceptable airborne bacterial counts. Copyright © 2015 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  13. Hea eramu valem? / Kaija-Luisa Kurik

    Index Scriptorium Estoniae

    Kurik, Kaija-Luisa

    2008-01-01

    27. VI-12. VII Arhitektuuri- ja Disainigaleriis avatud näitusest "Eesti eramu 2006-2007". Eksponeerti valikut Eesti Arhitektide Liidu korraldatud Eesti 2006.-2007. aasta parima eramu konkursile esitatud töödest. Kuraator Ene Läkk. Konkursi võidutöö: Villa Lokaator Paldiskis (arhitektid Siiri Vallner, Indrek Peil)

  14. Teater täis sära ja müstikat / Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Randküla, Ell-Maaja, 1939-2016

    2005-01-01

    Tallinnas Pärnu mnt. 5 asuva Eesti Draamateatri renoveerimine. Sisekujundus: Mari Kurismaa, Stuudio Kurismaa. Arhitektuurne lahendus: AB Kolde Grupp ( arhitektid Peep Jänes, Indrek Suigusaar). Ehitus: AS Estconde E. Mari Kurismaast, tema tähtsamad loomingulised saavutused maalikunstnikuna ja sisearhitektina. M. Kurismaa kommentaarid. Ill.: plaan, 10 värv. vaadet

  15. Estconil jagati taas Stalkereid / Jüri Kallas

    Index Scriptorium Estoniae

    Kallas, Jüri

    2006-01-01

    Ulmeauhind Stalker 2006 - tõlkeromaan: Lukjanenko, Sergei. Peegelduste labürint / tõlkinud Tanel Rõigas; antoloogia või tõlkekogu: Arvi Nikkarevi koostatud antoloogia "Aphra"; tõlkejutt: Vance, Jack. Puukoi; algupärane raamat: Hargla, Indrek. French ja Koulu; algupärane jutt: Belials, Veiko. Wereke, wereke, ega sa wesi...

  16. Õiguskantsleri pädevus Riigikogu liikme immuniteedimenetluses. Juhtumianalüüs / Juhan Sarv

    Index Scriptorium Estoniae

    Sarv, Juhan

    2012-01-01

    8. oktoobril 2012. a keeldus õiguskantsler Indrek Teder tegemast Riigikogule põhiseaduse § 76 teises lauses ja kriminaalmenetluse seadustiku § 378 lõikes 1 ettepanekut anda nõusolek Riigikogu liikmete Priit Toobali ja Lauri Laasi kriminaalvastutusele võtmiseks. Õiguskantsleri pädevusest ja taotluse tagastamise õiguslikust tähendusest

  17. Tornimäe kaksiktornid Tallinnas. Konkursi "Aasta betoonehitis 2007" nominent / Meeli Truu, Juhan Idnurm, Jaan Port...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    AS Nord Projekt; konstruktorid: Juhan Idnurm, Jaan Port, Kaido Kuusiku (Nord Projekt AS), Indrek Heinloo (E-Inseneribüroo OÜ), Matis Teeäär (Neoprojekt OÜ), Kaido Pärl (TAA-Konsult); ehitajad: Lemminkäinen Eesti AS, AS Merko Ehitus; betooni ja betoonelementide tarnijad: AS Rudus Eesti, AS Betoneks

  18. Mahtra talurahvamuuseumi uue hoone arhitektuurse eskiisprojekti võistluse...

    Index Scriptorium Estoniae

    2005-01-01

    Hindamiskomisjon (osalejad loetletud) andis I preemia Tomomi Hayashi ja Hanno Grossschmidti (HG Arhitektuur) võistlustööle "Heinamaa", II - Andres Lemberi (Male Arhitektid) võistlustöö "Talgud", III - Liina Jaanuse võistlustöö "Pärand", ergutuspreemia - Indrek Järve (Schults ja Partnerid) võistlustöö "Part"

  19. Благодаря лекциям одной минуты наука стала ближе / Айри Илиссон-Круз ; интервьюировала Ада Мальцева

    Index Scriptorium Estoniae

    Илиссон-Круз, Айри, 1980-

    2014-01-01

    Tallinna Ülikooli loengute sarjast, mille idee autor ja konsultant on Balti Filmi- ja Meediakooli õppejõud Indrek Treufeldt, kaasa löövad Tallinna Ülikooli turundus- ja kommunikatsiooniosakond, produtsent Airi Ilisson-Cruz ja e-õppekeskus, operaatorid-monteerijad Kristjan Madalvee ja Tarmo Lehari. Intervjuu loengusarja produtsendi Airi Ilisson-Cruziga

  20. Ühe minuti loengute abil jõuavad väärt teadmised kiiresti ja mugavalt huvilisteni / Airi Ilisson-Cruz ; intervjueerinud Ada Maltseva

    Index Scriptorium Estoniae

    Ilisson-Cruz, Airi, 1980-

    2014-01-01

    Tallinna Ülikooli loengute sarjast, mille idee autor ja konsultant on Balti Filmi- ja Meediakooli õppejõud Indrek Treufeldt, kaasa löövad Tallinna Ülikooli turundus- ja kommunikatsiooniosakond, produtsent Airi Ilisson-Cruz ja e-õppekeskus, operaatorid-monteerijad Kristjan Madalvee ja Tarmo Lehari. Intervjuu loengusarja produtsendi Airi Ilisson-Cruziga

  1. Arhetüüpse ja shiki kohtumine : ärihoone "Ferrum" Saaremaal Kuressaares = Encounter of Archetypal and Chic : Ferrum Centre in Saaremaa in Kuressaare / Ingrid Lillemägi

    Index Scriptorium Estoniae

    Lillemägi, Ingrid

    2003-01-01

    Projekteerija: Alver Trummal Arhitektid. Autorid Andres Alvar, Tiit Trummal, Tarmo Laht, Indrek Rünkla, Ulla Mets. Konstruktor Jaak Juha (Tööstusprojekt). Projekt 2001, valmis 2002. Stiilse ruumi vastuolu seda asustavate poodide kirju kribu-krabu ja juhuslike reklaamplakatitega. I ja II korruse plaan, 5 välis- ja 2 sisevaadet

  2. Tänavused Stalkerid välja kuulutatud

    Index Scriptorium Estoniae

    2004-01-01

    Ulmeauhind "Stalker": tõlked: Stephenson, Neal. Lumevaring (tõlkija Juhan Habicht) ja Martin, George R. R. Liivakuningad (tõlkija Mario Kivistik); tõlkekogumik: Silverberg, Robert. Meid ootab pimedus; algupärandid: Trinity, André. Tähtede seis ja Hargla, Indrek. Vlad. Vt. ka Looming, 2004, nr. 8, lk. 1270-1271

  3. LHV kinnitusel liigutas Lõhmuse nimel miljoneid dollareid Peek / Lauri Matsulevitsh, Annika Matson

    Index Scriptorium Estoniae

    Matsulevitsh, Lauri

    2005-01-01

    Lisaks LHV töötajatele Oliver Peegile ja Kristjan Lepikule on konfidentsiaalse info põhjal toimunud börsitehingutega seotud ka LHV osanik Rain Lõhmus. Vt. samas: Mismoodi Lõhmuse kontol raha liikus?; LHVs kahte tüüpi kontod. Kommenteerivad Joakim Helenius, Jüri Mõis, Rein Kilk ja Indrek Neivelt

  4. Romaanid ja trend / Teet Kallas

    Index Scriptorium Estoniae

    Kallas, Teet, 1943-

    2003-01-01

    Romaanivõistluse parimatest: Nikolai Baturini "Kentaur", Indrek Hargla "Vabaduse kõrgeim määr" ja Enn Põldroosi "Joonik kivi"; ka äramärgitud töödest: Sass Henno "Elu algab täna", Agu Tammeveski "Kas teie olite siis teistsugune?" ja Erik Tohvri "Tants läbi rukki"

  5. Novõi utshebnõi god budjet Godom dizaina / Ksenia Repson

    Index Scriptorium Estoniae

    Repson, Ksenia

    2006-01-01

    Eesti Kunstiakadeemia disainihariduse 40. aastapäeva tähistava Disainiaasta üritusi: rahvusvaheline disainikonverents Connecting, näitus "40 aastat disaini" Tarbekunsti- ja Disainimuuseumis, disainikonkurss, rändnäitused, seminarid, Tallinna disainikaart (koostab Kai Lobjakas, joonistavad Indrek Sirkel ja Mikk Heinsoo). Projekti "Disainiaasta" juht on Ruth Helene Melioranski

  6. Järve Selver = Järve Selver / Jaak Huimerind

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2000-01-01

    Projekteerija: Arhitektuuribüroo Studio Paralleel. Arhitektid Jaak Huimerind, Indrek Saarepera. Konstruktiivne osa: Neoprojekt. I korruse avaliku tsooni värvilahendus sisearhitekt Mari Kurismaalt. Kauplused ja kontorid kujundas Tallinna Kaubamaja, toitlustuskohad\\\\ARS Interjöörprojekt. Projekt 1998-2000, valmis 2000. 9 ill.: korruste plaanid, välis- ja sisevaated

  7. Herman Simm põhjendab reetmist KGB minevikuga / Risto Berendson, Rasmus Kagge

    Index Scriptorium Estoniae

    Berendson, Risto, 1975-

    2008-01-01

    Riigireetmises uurimise all viibiva Herman Simmi väidetel langes ta KGB šantaaži ohvriks. Vt. samas: Indrek Jürjo. KGB lähiajalugu Eestis püsib ähmasena; Vladimir Jushkin. Agentide nimed jäävad igaveseks saladuseks; Hardo Aasmäe. Agentuuritoimikud viidi Eestist minema

  8. Lahemaa RPA vaidlustas Valgejõe paisutamise Nõmmeveskil / Ülle Tamm

    Index Scriptorium Estoniae

    Tamm, Ülle, 1962-

    2004-01-01

    Keskkonnainspektsioon uurib Lahemaa Rahvuspargi administratsiooni palvel AS-i Maru poolt Valgejõele tekitatud paisjärve mõjusid looduskeskkonnale. Paisjärve toetuseks võtavad sõna külavanem Ira Laasi, Loksa vallavanem Madis Praks ja AS-i Maru juhatuse liige Heiki Laiverik. Lahemaa Rahvuspargi seisukohta selgitab Lauri-Indrek Tummeleht

  9. The relationship between demand and need for orthodontic treatment in high school students in Bangkok.

    Science.gov (United States)

    Atisook, Pitraporn; Chuacharoen, Rattiya

    2014-07-01

    Orthodontic service is limited in Thailand and cannot meet the demand of the population. (1) To assess the need for orthodontic treatment (OT) using the Index of Orthodontic Treatment Need (IOTN) to analyze the relationship between demand and need for OT and (2) to compare the demand and need for OT between genders. A cross-sectional study was conducted on 450 students aged 12- to 14-years-old in three government high schools in Bangkok. A constructed questionnaire was used to assess demand for OT Clinical examination was done by two orthodontists to determine the needfor OT using the IOTN RESULTS: Most of the students (74.0%) wished to have OT while only one-third (37.5%) had severe need, and one-third (34.4%) had moderate need for OT as judge by the DHC of the IOTN. The AC of the IOTN indicated that most students (55.8%) had mild or no need for OT Females (79%) demanded OT more than males (66% p-value = 0.033) but the need was similar in both sexes. Most functional factors had strong relationships with the demand for OTexcept lower teeth bite on palate, but none was found to be associated with need for OT All of the aesthetic factors had strong relationships with demand for OT There were significant relationships with needs in five categories, 1) crooked, crowded, or spacing teeth, 2) worried when speaking or smiling, 3) had suggestedfor OT 4) breath smell and halitosis, and 5) wanted to put on braces to be like other people or for fashionable reasons. Most of the students requested OT but females had significantly higher demand for OT than males. Most of the samples needed to have OT The aesthetic factors that had strong relationships with the need for OT were 1) crooked, crowded, or spacing teeth, 2) worried when speaking or smiling, 3) had suggested for T07 4) breath smell and halitosis, and 5) wanted to put on braces to be like otherpeople orfor fashionable reasons.

  10. Oxytocin Removes Estrous Female vs. Male Preference of Virgin Male Rats: Mediation of the Supraoptic Nucleus Via Olfactory Bulbs

    Directory of Open Access Journals (Sweden)

    Xiao-Yu Liu

    2017-10-01

    Full Text Available Social functions of oxytocin (OT have been explored extensively; however, relationship between the effect of intranasally applied OT (nasal OT on the social preference (SP and intracerebral actions of endogenous OT remains unclear. To resolve this question, we first observed effects of nasal OT on the SP of virgin young adult male rats toward unfamiliar virgin estrous female (EF vs. virgin male rats. The results showed that the test male rats exhibited significantly more times and longer duration accessing the female than the male, which were acutely eliminated by nasal OT. Then, we examined the approaches mediating nasal OT effects on the activity of potential brain targets in Western blots and found that nasal OT activated the olfactory bulbs (OBs and the supraoptic nucleus (SON, but not the piriform cortex, amygdala and hippocampus as shown by significant changes in the expression of c-Fos and/or phosphorylated extracellular signal-regulated protein kinase (pERK 1/2. Moreover, microinjection of TTX into the OBs blocked nasal OT-evoked increases in pERK1/2 levels as well as the molecular association between ERK1/2 and OT-neurophysin in the SON. Electrolytic lesions of the lateral olfactory tract did not significantly change the basal levels of pERK 1/2 in the SON; however, upon nasal OT, pERK 1/2 levels in the SON reduced significantly. Lastly, microinjection of L-aminoadipic acid (gliotoxin into the SON to reduce OT levels reduced the duration of the test male’s accessing the EF and blocked the nasal OT-evoked increase in the duration of test male’s accessing the male while significantly increasing pERK1/2 levels in the amygdala. These findings reveal for the first time that nasal OT acutely eliminates virgin males’ SP to EFs via the OB-SON route and that OT neurons could mediate the social effects of nasal OT by suppressing social phobia generated in the amygdala.

  11. Oxytocin as a novel therapeutic option for type I diabetes and diabetic osteopathy.

    Science.gov (United States)

    Elabd, S K; Sabry, I; Mohasseb, M; Algendy, A

    2014-04-01

    The aim of the present study was to highlight the newly discovered metabolic role of oxytocin (OT) in the type I diabetic rats. Previous studies have demonstrated that OT has a beneficial role on bone physiology and therefore, the OT effect on the diabetic osteopathy will be assessed as well. Induction of the type I diabetes was carried out by an intraperitoneal injection of 60 mg/kg body weight of streptozotocin. The metabolic role of OT on diabetic rats after OT treatment with intramuscular injection of 40 µIU/kg body weight for 6 weeks was assessed. Histological and ultrastructural studies of rat pancreas samples, before and after the OT injection, were performed and compared with the obtained physiological results. Oxytocin treatment had positive metabolic effects in diabetic rats. This is based on the change in glucose metabolism, lipid profile, and insulin sensitivity in experimental animals. In addition, OT treatment showed histological regenerative changes of pancreatic islet cells of diabetic rats. Moreover, OT administration showed that it has an anabolic effect on the bone biology. The results suggest that activation of the oxytocin receptor (OTR) pathway by infusion of OT, OT analogs, or OT agonists may represent a promising approach for the treatment of diabetes and some of its complications, including diabetic osteopathy.

  12. Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study.

    Science.gov (United States)

    Daughters, Katie; Manstead, Antony S R; Hubble, Kelly; Rees, Aled; Thapar, Anita; van Goozen, Stephanie H M

    2015-01-01

    The use of intranasal oxytocin (OT) in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have actually done so. In the present double-blind cross-over study we investigated the longevity of a single 24 IU dose of intranasal OT measured in saliva in 40 healthy adult males. Salivary OT concentrations were significantly higher in the OT condition, compared to placebo. This significant difference lasted until the end of testing, approximately 108 minutes after administration, and peaked at 30 minutes. Results showed significant individual differences in response to intranasal OT administration. To our knowledge this is the largest and first all-male within-subjects design study to demonstrate the impact of intranasal OT on salivary OT concentrations. The results are consistent with previous research in suggesting that salivary OT is a valid matrix for OT measurement. The results also suggest that the post-administration 'wait-time' prior to starting experimental tasks could be reduced to 30 minutes, from the 45 minutes typically used, thereby enabling testing during peak OT concentrations. Further research is needed to ascertain whether OT concentrations after intranasal administration follow similar patterns in females, and different age groups.

  13. Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study.

    Directory of Open Access Journals (Sweden)

    Katie Daughters

    Full Text Available The use of intranasal oxytocin (OT in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have actually done so. In the present double-blind cross-over study we investigated the longevity of a single 24 IU dose of intranasal OT measured in saliva in 40 healthy adult males. Salivary OT concentrations were significantly higher in the OT condition, compared to placebo. This significant difference lasted until the end of testing, approximately 108 minutes after administration, and peaked at 30 minutes. Results showed significant individual differences in response to intranasal OT administration. To our knowledge this is the largest and first all-male within-subjects design study to demonstrate the impact of intranasal OT on salivary OT concentrations. The results are consistent with previous research in suggesting that salivary OT is a valid matrix for OT measurement. The results also suggest that the post-administration 'wait-time' prior to starting experimental tasks could be reduced to 30 minutes, from the 45 minutes typically used, thereby enabling testing during peak OT concentrations. Further research is needed to ascertain whether OT concentrations after intranasal administration follow similar patterns in females, and different age groups.

  14. Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats

    Science.gov (United States)

    Hicks, C; Ramos, L; Reekie, T; Misagh, G H; Narlawar, R; Kassiou, M; McGregor, I S

    2014-01-01

    Background and Purpose There is current interest in oxytocin (OT) as a possible therapeutic in psychiatric disorders. However, the usefulness of OT may be constrained by peripheral autonomic effects, which may involve an action at both OT and vasopressin V1A receptors. Here, we characterized the cardiovascular and thermoregulatory effects of OT, vasopressin (AVP) and the non-peptide OT receptor agonist WAY 267,464 in rats, and assessed the relative involvement of the OT and V1A receptors in these effects. Experimental Approach Biotelemetry in freely moving male Wistar rats was used to examine body temperature and heart rate after OT (0.01 – 1 mg kg−1; i.p.), AVP (0.001 – 0.1 mg kg−1; i.p.) or WAY 267,464 (10 and 100 mg kg−1; i.p.). The actions of the OT receptor antagonist Compound 25 (C25, 5 and 10 mg kg−1) and V1A receptor antagonist SR49059 (1 and 10 mg kg−1) were studied, as well as possible V1A receptor antagonist effects of WAY 267,464. Key Results OT and AVP dose-dependently reduced body temperature and heart rate. WAY 267,464 had similar, but more modest, effects. SR49059, but not C25, prevented the hypothermia and bradycardia induced by OT and AVP. WAY 267,464 (100 mg·kg−1) prevented the effects of OT, and to some extent AVP. Conclusions and Implications Peripherally administered OT and AVP have profound cardiovascular and thermoregulatory effects that appear to principally involve the V1A receptor rather than the OT receptor. Additionally, WAY 267,464 is not a simple OT receptor agonist, as it has functionally relevant V1A antagonist actions. PMID:24641248

  15. Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats.

    Science.gov (United States)

    Hicks, C; Ramos, L; Reekie, T; Misagh, G H; Narlawar, R; Kassiou, M; McGregor, I S

    2014-06-01

    There is current interest in oxytocin (OT) as a possible therapeutic in psychiatric disorders. However, the usefulness of OT may be constrained by peripheral autonomic effects, which may involve an action at both OT and vasopressin V1A receptors. Here, we characterized the cardiovascular and thermoregulatory effects of OT, vasopressin (AVP) and the non-peptide OT receptor agonist WAY 267,464 in rats, and assessed the relative involvement of the OT and V1A receptors in these effects. Biotelemetry in freely moving male Wistar rats was used to examine body temperature and heart rate after OT (0.01 - 1 mg kg(-1); i.p.), AVP (0.001 - 0.1 mg kg(-1); i.p.) or WAY 267,464 (10 and 100 mg kg(-1); i.p.). The actions of the OT receptor antagonist Compound 25 (C25, 5 and 10 mg kg(-1)) and V1A receptor antagonist SR49059 (1 and 10 mg kg(-1)) were studied, as well as possible V1A receptor antagonist effects of WAY 267,464. OT and AVP dose-dependently reduced body temperature and heart rate. WAY 267,464 had similar, but more modest, effects. SR49059, but not C25, prevented the hypothermia and bradycardia induced by OT and AVP. WAY 267,464 (100 mg·kg(-1)) prevented the effects of OT, and to some extent AVP. Peripherally administered OT and AVP have profound cardiovascular and thermoregulatory effects that appear to principally involve the V1A receptor rather than the OT receptor. Additionally, WAY 267,464 is not a simple OT receptor agonist, as it has functionally relevant V1A antagonist actions. © 2014 The British Pharmacological Society.

  16. Human ovolution and plasma oxytocin

    International Nuclear Information System (INIS)

    Kumaresan, Perianna; Kumaresan, Malathi; Hossini, Mahmood; Arellano, Carolina; Vasicka, Alois

    1983-01-01

    Plasma oxytocin (OT) concentrations were measured by radioimmunoassay (RIA) method without extracting plasma in 11 normal menstruating women. Mean plasma OT level began to increase steadily from the 7th day of the menstrual cycle and this level rose up to 20+-5 μU/ml (Mean+-S.E.) on the 10th day of the cycle. OT level declined to 13+-6 μU/ml on the day of the LH peak and continuously declined for another 2 days - then rose. The OT level was higher during the follicular phase than during the luteal phase. In 1 individual OT measured in 2 cycles a year apart showed the highest level of OT coincided with LH and FSH peak and abruptly declined. When there was the highest level of progesterone, the OT level was measurable 1 out of 11 cycles. From this study, we conclude that OT may have a role in human ovulation either synergistically or alone with other ovulatory mechanisms and ovarian estradiol and progesterone control the secretion of OT and also suggests that OT may play some role in the regulation of the luteolysis and the menstrual cycle in women. (author)

  17. Raznõje litsa Indreka Paasa / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2008-01-01

    Vargamäel 22 tundi kestnud maratonetendusest Tammsaare "Tõe ja õiguse" põhjal - Elmo Nüganeni lavastused "Tõde ja õigus. Teine osa", "Karin. Indrek. Tõde ja õigus. 4" ja "Wargamäe Wabariik" (III osa) ning Jaanus Rohumaa lavastus "Vargamäe kuningriik" (I ja V osa). Pikemalt "Wargamäe Wabariigi" lavastusest

  18. Gallup : kirjandus, kirjanik, kriitika ja kriitik : [küsitlus

    Index Scriptorium Estoniae

    2005-01-01

    Küsimustele vastavad: Jan Kaus, Arne Merilai, Aarne Ruben, Peeter Sauter, Asta Põldmäe, Aare Pilv, Arvo Valton, Lauri Sommer, Mari Laaniste, Toomas Raudam, Ivar Sild, Olev Remsu, Kalle Kurg, Fagira D Morti, Eeva Park, Neeme Lopp, Valle-Sten Maiste, Sirli Ojaste, Ene-Reet Soovik, Märt Väljataga, Indrek Mesikepp

  19. BIG tahab pangaks saada / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti : Finansõ 19. jaan. 2005 lk. 2. Kiirlaenukontorina tegutsev Balti Investeringute Grupp tahab saada pangaks. Kommenteerivad Ain Hanschmidt, Loit Linnupõld, Indrek Neivelt ja Alvar Jõgeva. Vt. samas: Krista Taim. Väikeinvestor kiidab BIG-i soodsat protsenti; Kiirelt saadud laen tänini kukil ja suhted sugulastega sassis

  20. Versija Hermana Simma : menja shantazhirovali / Risto Berendson, Rasmus Kagge

    Index Scriptorium Estoniae

    Berendson, Risto, 1975-

    2008-01-01

    Riigireetmises uurimise all viibiva Herman Simmi väidetel langes ta KGB šantaaži ohvriks. Vt. samas: Indrek Jürjo. KGB lähiajalugu Eestis püsib ähmasena; Vladimir Jushkin. Agentide nimed jäävad igaveseks saladuseks; Hardo Aasmäe. Agentuuritoimikud viidi Eestist minema; Herman Simmi arreteerimine

  1. Mati Polli : metsameeste ikoon / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2008-01-01

    Endise puidutööstuse Sylvester asutaja Mati Polli on metsameeste keskel kujunenud ikooniks ja elavaks legendiks. Vt. samas: Elulugu; Tasub teada; Maksuametil kaotuseid jätkub. Kommenteerivad: ASi Pärnu Mets juhataja Ants Kaljund, ehitusettevõtja Andres Koger, Arengufondi nõukogu esimees Indrek Neivelt ja EMTL juht Andres Talijärv

  2. Eesti Disainiauhinnad 2012

    Index Scriptorium Estoniae

    2012-01-01

    Bruno 2012 parima tootedisaini kategoorias võitis Margus Triibmanni rattahoidja TULIP FAN FAN. Parim disainiprojekt - KOKO Arhitektide projekteeritud Lennusadam. Noore disaineri auhind Säsi läks jagamisele Kärt Ojavee, Elena Karelsoni ja Indrek Sirkeli vahel. Grand prix omistati trükisele "HULA. Inimeste peal testitud" (disainerid Mariana Hint, Agnes Ratas)

  3. Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers.

    Science.gov (United States)

    Cavanaugh, Jon; Mustoe, Aaryn C; Taylor, Jack H; French, Jeffrey A

    2014-11-01

    Behavioral strategies that facilitate the maintenance of social bonds are critical for the preservation of high-quality social relationships. Central oxytocin (OT) activity modulates the behavioral features of socially monogamous relationships in a number of mammalian species (including marmoset monkeys), and plays a vital role in the behavioral maintenance of long-term social relationships. Two distinct variants of OT have been identified in some New World primates (including marmosets; Lee et al., 2011). The marmoset variant of the oxytocin ligand (Pro(8)-OT) is structurally distinct from the consensus mammalian variant of the oxytocin ligand (Leu(8)-OT), due to a proline substitution at the 8th amino-acid position. The goal of the present study was to determine if treating marmosets with Pro(8)-OT, relative to treatments with Leu(8)-OT, control saline, or an OT antagonist, had modulatory effects on the behavioral maintenance of long-term social relationships in marmosets. Treatment with the Pro(8) variant, but not the Leu(8) variant, of OT facilitated fidelity with a long-term partner by reducing time spent in close proximity with an opposite-sex stranger. However, this facilitative effect of Pro(8)-OT on proximity behavior manifested itself differently in male and female marmosets, such that females preferred to interact socially with their partner rather than a stranger when treated with Pro(8)-OT, while males spent less time in close proximity with both their partner and a stranger when treated with Pro(8)-OT. Furthermore, treatment with Pro(8)-OT, but not Leu(8)-OT, significantly delayed the expression of sexual solicitation behavior toward an opposite-sex stranger in both male and female marmosets, but had no effect on sociosexual behavior directed toward a long-term partner. These results suggest that the OT system is highly involved in reducing fidelity-threatening behaviors in well-established marmoset pairs, and that the effects were only produced by

  4. The organizational effects of oxytocin on the central expression of estrogen receptor α and oxytocin in adulthood

    Directory of Open Access Journals (Sweden)

    Papademetriou Eros

    2007-09-01

    Full Text Available Abstract Background Previous studies have demonstrated that neonatal manipulation of oxytocin (OT has effects on the expression of estrogen receptor α (ERα and the central production of oxytocin observed in juveniles (at weaning, 21 days of age. The goal of this study was to determine whether the effects of neonatal manipulation of OT last into adulthood, and if the effects differ from those observed during the early postnatal period. On the first day of life, prairie voles (Microtus ochrogaster received one of three doses of OT (High, 3 μg; Med, 0.3 μg; Low, 0.03 μg, an OT antagonist, or isotonic saline. Another group was handled, but not injected. Then as adults, brains were collected, sectioned, and stained for ERα or OT using immunocytochemistry. Results In females, treatment with OT increased the expression of ERα immunoreactivity in the ventral lateral septum (0.03 μg and the ventromedial nucleus of the hypothalamus and central amygdala (0.3 μg. In males, OT antagonist increased ERα expression in the bed nucleus of the stria terminalis. There was no apparent effect of OT on the number of cells producing OT in the paraventricular nucleus of the hypothalamus. Conclusion The current results suggest that neonatal manipulation of OT has long-term organizational effects on the expression of ERα in both males and females. The lack of effect on OT neurons in the paraventricular nucleus suggests that some developmental effects of OT previously observed in weanlings do not persist into adulthood. Developmental effects of OT on ERα patterns were sexually dimorphic, dose-dependent, and site-specific.

  5. Conditioned same-sex partner preference in male rats is facilitated by oxytocin and dopamine: effect on sexually dimorphic brain nuclei.

    Science.gov (United States)

    Triana-Del Rio, Rodrigo; Tecamachaltzi-Silvarán, Miriam B; Díaz-Estrada, Victor X; Herrera-Covarrubias, Deissy; Corona-Morales, Aleph A; Pfaus, James G; Coria-Avila, Genaro A

    2015-04-15

    Conditioned same-sex partner preference can develop in male rats that undergo cohabitation under the effects of quinpirole (QNP, D2 agonist). Herein, we assessed the development of conditioned same-sex social/sexual preference in males that received either nothing, saline, QNP, oxytocin (OT), or QNP+OT during cohabitation with another male (+) or single-caged (-). This resulted in the following groups: (1) Intact-, (2) Saline+, (3) QNP-, (4) OT-, (5) QNP+, (6) OT+ and (7) QNP/OT+. Cohabitation occurred during 24h in a clean cage with a male partner that bore almond scent on the back as conditioned stimulus. This was repeated every 4 days for a total of three trials. Social and sexual preference were assessed four days after the last conditioning trial in a drug-free test in which experimental males chose between the scented familiar male and a novel sexually receptive female. Results showed that males from groups Intact-, Saline+, QNP- and OT- displayed a clear preference for the female (opposite-sex), whereas groups QNP+, OT+ and QNP/OT+ displayed socio/sexual preference for the male partner (same-sex). In Experiment 2, the brains were processed for Nissl dye and the area size of two sexually dimorphic nuclei (SDN-POA and SON) was compared between groups. Males from groups OT-, OT+ and QNP/OT+ expressed a smaller SDN-POA and groups QNP+ and QNP/OT+ expressed a larger SON. Accordingly, conditioned same-sex social/sexual partner preference can develop during cohabitation under enhanced D2 or OT activity but such preference does not depend on the area size of those sexually dimorphic nuclei. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Detection of Tropical Overshooting Cloud Tops Using Himawari-8 Imagery

    Directory of Open Access Journals (Sweden)

    Miae Kim

    2017-07-01

    Full Text Available Abstract: Overshooting convective cloud Top (OT-accompanied clouds can cause severe weather conditions, such as lightning, strong winds, and heavy rainfall. The distribution and behavior of OTs can affect regional and global climate systems. In this paper, we propose a new approach for OT detection by using machine learning methods with multiple infrared images and their derived features. Himawari-8 satellite images were used as the main input data, and binary detection (OT or nonOT with class probability was the output of the machine learning models. Three machine learning techniques—random forest (RF, extremely randomized trees (ERT, and logistic regression (LR—were used to develop OT classification models to distinguish OT from non-OT. The hindcast validation over the Southeast Asia and West Pacific regions showed that RF performed best, resulting in a mean probabilities of detection (POD of 77.06% and a mean false alarm ratio (FAR of 36.13%. Brightness temperature at 11.2 μm (Tb11 and its standard deviation (STD in a 3 × 3 window size were identified as the most contributing variables for discriminating OT and nonOT classes. The proposed machine learning-based OT detection algorithms produced promising results comparable to or even better than the existing approaches, which are the infrared window (IRW-texture and water vapor (WV minus IRW brightness temperature difference (BTD methods.

  7. CSF and blood oxytocin concentration changes following intranasal delivery in macaque.

    Directory of Open Access Journals (Sweden)

    Olga Dal Monte

    Full Text Available Oxytocin (OT in the central nervous system (CNS influences social cognition and behavior, making it a candidate for treating clinical disorders such as schizophrenia and autism. Intranasal administration has been proposed as a possible route of delivery to the CNS for molecules like OT. While intranasal administration of OT influences social cognition and behavior, it is not well established whether this is an effective means for delivering OT to CNS targets. We administered OT or its vehicle (saline to 15 primates (Macaca mulatta, using either intranasal spray or a nebulizer, and measured OT concentration changes in the cerebral spinal fluid (CSF and in blood. All subjects received both delivery methods and both drug conditions. Baseline samples of blood and CSF were taken immediately before drug administration. Blood was collected every 10 minutes after administration for 40 minutes and CSF was collected once post-delivery, at the 40 minutes time point. We found that intranasal administration of exogenous OT increased concentrations in both CSF and plasma compared to saline. Both delivery methods resulted in similar elevations of OT concentration in CSF, while the changes in plasma OT concentration were greater after nasal spray compared to nebulizer. In conclusion our study provides evidence that both nebulizer and nasal spray OT administration can elevate CSF OT levels.

  8. The Mediating Role of Organizational Trust on The Effects of Servant Leader ship and Organizational Justice on Organizational Identification

    Directory of Open Access Journals (Sweden)

    Fikret Ateş

    2015-09-01

    Full Text Available The aim of this study determined to research whether was affected Organizational Identification (OI by Servant Leadership (SL, Organizational Justice (OJ, Organizational Trust (OT and, how was affected OI by SL and OJ and, whether there is an indirecteffect of OT on the relations of OI-SL and OI-OJ. For these aims, the questionnaire was developed with Dennis and Bocerne (2006's SL scale, Colquitt (2001's OJ scale, Mael and Ashforth (1992's OI scale, Bromiley and Cummings (1996’s OT scale. The validity of scales authenticated with multi-factor structure for SL, OJ, and OT, with one factor structure for OI. The reliability of scales were calculated as Cronbach's alpha (α values (SL=0.95; OJ=0.93, OT=0.76, OI=0.87. According to the hypothesis tests which done by Structural Equation Models; has that there are direct positive effects between SL, OJ, OT and OI or between SL, OJ and OT; finally has determined that there are positive and partial indirect effects between OT and SL-OI or between OT andOJ-OI.

  9. Awareness and Use of Electronic Health Records in Entry-Level Occupational Therapy and Occupational Therapy Assistant Curricula

    Directory of Open Access Journals (Sweden)

    Louis F. Dmytryk

    2017-03-01

    Full Text Available The Accreditation Council for Occupational Therapy Education (ACOTE requires programs to instruct entrylevel occupational therapy (OT and occupational therapy assistant (OTA students in technology that may include electronic documentation systems, distance communication, virtual environments, and telehealth (standard B1.8. At this time, there are no publications describing if and how electronic health record (EHR instruction is implemented in entry-level OT and OTA programs. The purpose of this study is to investigate awareness and use of EHRs in entry-level OT and OTA curricula. Respondents from 76 nationally accredited entry-level programs (two OT doctoral, 24 OT masters, two OT combined bachelors/masters, and 48 OTA completed a survey. The findings showed inconsistent and incomplete EHR instruction in entry-level OT and OTA education. This study provides a baseline for investigating best practices in EHR education for entrylevel OT and OTA students

  10. Resenha de 1976: Movimento Black Rio, de Luiz Felipe de Lima Peixoto e Zé Otávio Sabadelhe (Rio de Janeiro: José Olympio, 2016

    Directory of Open Access Journals (Sweden)

    Carlos Palombini

    2017-08-01

    Full Text Available Lançado em 10 de novembro de 2016, o livro 1976: Movimento Black Rio, dos jornalistas Luiz Felipe de Lima Peixoto e Zé Otávio Sabadelhe, celebra os quarenta anos da manchete de Lena Frias, Black Rio: o orgulho (importado de ser negro no Brasil, publicada em 17 de julho de 1976 no Caderno B do Jornal do Brasil. Em 28 reportagens, os autores recorrem a entrevistas e material previamente publicado para contar a história da cultura de bailes que, alimentados por soul, funk e disco afro-norte-americanos, espalharam-se pela Zona Norte carioca nos anos 1970, bem como a história do conjunto das apropriações desses gêneros por Tim Maia, Toni Tornado, Hyldon, Carlos Dafé, Cassiano, Gerson King Combo, Dom Salvador e Abolição, União Black, e Banda Black Rio. O livro tenciona constituir “uma contribuição à construção discursiva de uma memória social positiva da população negra brasileira” e oferece elementos para um trabalho necessário de revisão historiográfica que transcende o âmbito do tema tratado, apesar de erros fatuais que poderiam ter sido corrigidos por cruzamento de dados.

  11. Central oxytocin and food intake: focus on macronutrient-driven reward

    Directory of Open Access Journals (Sweden)

    Anica eKlockars

    2015-04-01

    Full Text Available Centrally acting oxytocin (OT is known to terminate food consumption in response to excessive stomach distension, increase in salt loading and presence of toxins. Hypothalamic-hindbrain OT pathways facilitate these aspects of OT-induced hypophagia. However, recent discoveries have implicated OT in modifications of feeding via reward circuits: OT has been found to differentially affect consumption of individual macronutrients in choice and no-choice paradigms. In this mini-review, we focus on presenting and interpreting evidence that defines OT as a key component of mechanisms that reduce eating for pleasure and shape macronutrient preferences. We also provide remarks on challenges in integrating the knowledge on physiological and pathophysiological states in which both OT activity and macronutrient preferences are affected.

  12. The role of oxytocin in cardiovascular regulation

    Directory of Open Access Journals (Sweden)

    J. Gutkowska

    2014-03-01

    Full Text Available Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT-ergic neurons is responsible for ANP release, and it has become clear that activation of neuronal circuitry elicits OT secretion into the circulation, activating atrial OT receptors and ANP release from the heart. Subsequently, we have uncovered the entire functional OT system in the rat and the human heart. An abundance of OT has been observed in the early development of the fetal heart, and the capacity of OT to generate cardiomyocytes (CMs has been demonstrated in various types of stem cells. OT treatment of mesenchymal stem cells stimulates paracrine factors beneficial for cardioprotection. Cardiovascular actions of OT include: i lowering blood pressure, ii negative inotropic and chronotropic effects, iii parasympathetic neuromodulation, iv vasodilatation, v anti-inflammatory activity, vi antioxidant activity, and vii metabolic effects. OT actions are mediated by nitric oxide and ANP. The beneficial actions of OT may include the increase in glucose uptake by CMs and stem cells, reduction in CM hypertrophy, oxidative stress, and mitochondrial protection of several cell types. In experimentally induced myocardial infarction in rats, continuous in vivo OT delivery improves cardiac healing and cardiac work, reduces inflammation, and stimulates angiogenesis. Because OT plays anti-inflammatory and cardioprotective roles and improves vascular and metabolic functions, it demonstrates potential for therapeutic use in various pathologic conditions.

  13. Manipulation of the oxytocin system alters social behavior and attraction in pair-bonding primates, Callithrix penicillata.

    Science.gov (United States)

    Smith, Adam S; Agmo, Anders; Birnie, Andrew K; French, Jeffrey A

    2010-02-01

    The establishment and maintenance of stable, long-term male-female relationships, or pair-bonds, are marked by high levels of mutual attraction, selective preference for the partner, and high rates of sociosexual behavior. Central oxytocin (OT) affects social preference and partner-directed social behavior in rodents, but the role of this neuropeptide has yet to be studied in heterosexual primate relationships. The present study evaluated whether the OT system plays a role in the dynamics of social behavior and partner preference during the first 3 weeks of cohabitation in male and female marmosets, Callithrix penicillata. OT activity was stimulated by intranasal administration of OT, and inhibited by oral administration of a non-peptide OT-receptor antagonist (L-368,899; Merck). Social behavior throughout the pairing varied as a function of OT treatment. Compared to controls, marmosets initiated huddling with their social partner more often after OT treatments but reduced proximity and huddling after OT antagonist treatments. OT antagonist treatment also eliminated food sharing between partners. During the 24-h preference test, all marmosets interacted more with an opposite-sex stranger than with the partner. By the third-week preference test, marmosets interacted with the partner and stranger equally with the exception that intranasal-OT treatments facilitated initial partner-seeking behavior over initial contact with the stranger. Our findings demonstrate that pharmacological manipulations of OT activity alter partner-directed social behavior during pair interactions, suggesting that central OT may facilitate the process of pair-bond formation and social relationships in marmoset monkeys. Published by Elsevier Inc.

  14. The role of oxytocin in cardiovascular regulation

    Energy Technology Data Exchange (ETDEWEB)

    Gutkowska, J.; Jankowski, M. [University of Montreal, CHUM Research Centre, Faculty of Medicine, Department of Medicine, Laboratory of Cardiovascular Biochemistry, Montreal, Quebec, Canada, Laboratory of Cardiovascular Biochemistry, Department of Medicine, Faculty of Medicine, University of Montreal, CHUM Research Centre, Montreal, Quebec (Canada); Antunes-Rodrigues, J. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Fisiologia, Ribeirão Preto, SP, Brasil, Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil)

    2014-03-03

    Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neuronal circuitry elicits OT secretion into the circulation, activating atrial OT receptors and ANP release from the heart. Subsequently, we have uncovered the entire functional OT system in the rat and the human heart. An abundance of OT has been observed in the early development of the fetal heart, and the capacity of OT to generate cardiomyocytes (CMs) has been demonstrated in various types of stem cells. OT treatment of mesenchymal stem cells stimulates paracrine factors beneficial for cardioprotection. Cardiovascular actions of OT include: i) lowering blood pressure, ii) negative inotropic and chronotropic effects, iii) parasympathetic neuromodulation, iv) vasodilatation, v) anti-inflammatory activity, vi) antioxidant activity, and vii) metabolic effects. OT actions are mediated by nitric oxide and ANP. The beneficial actions of OT may include the increase in glucose uptake by CMs and stem cells, reduction in CM hypertrophy, oxidative stress, and mitochondrial protection of several cell types. In experimentally induced myocardial infarction in rats, continuous in vivo OT delivery improves cardiac healing and cardiac work, reduces inflammation, and stimulates angiogenesis. Because OT plays anti-inflammatory and cardioprotective roles and improves vascular and metabolic functions, it demonstrates potential for therapeutic use in various pathologic conditions.

  15. The role of oxytocin in cardiovascular regulation

    International Nuclear Information System (INIS)

    Gutkowska, J.; Jankowski, M.; Antunes-Rodrigues, J.

    2014-01-01

    Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neuronal circuitry elicits OT secretion into the circulation, activating atrial OT receptors and ANP release from the heart. Subsequently, we have uncovered the entire functional OT system in the rat and the human heart. An abundance of OT has been observed in the early development of the fetal heart, and the capacity of OT to generate cardiomyocytes (CMs) has been demonstrated in various types of stem cells. OT treatment of mesenchymal stem cells stimulates paracrine factors beneficial for cardioprotection. Cardiovascular actions of OT include: i) lowering blood pressure, ii) negative inotropic and chronotropic effects, iii) parasympathetic neuromodulation, iv) vasodilatation, v) anti-inflammatory activity, vi) antioxidant activity, and vii) metabolic effects. OT actions are mediated by nitric oxide and ANP. The beneficial actions of OT may include the increase in glucose uptake by CMs and stem cells, reduction in CM hypertrophy, oxidative stress, and mitochondrial protection of several cell types. In experimentally induced myocardial infarction in rats, continuous in vivo OT delivery improves cardiac healing and cardiac work, reduces inflammation, and stimulates angiogenesis. Because OT plays anti-inflammatory and cardioprotective roles and improves vascular and metabolic functions, it demonstrates potential for therapeutic use in various pathologic conditions

  16. Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment.

    Science.gov (United States)

    Quintana, D S; Westlye, L T; Rustan, Ø G; Tesli, N; Poppy, C L; Smevik, H; Tesli, M; Røine, M; Mahmoud, R A; Smerud, K T; Djupesland, P G; Andreassen, O A

    2015-07-14

    Despite the promise of intranasal oxytocin (OT) for modulating social behavior, recent work has provided mixed results. This may relate to suboptimal drug deposition achieved with conventional nasal sprays, inter-individual differences in nasal physiology and a poor understanding of how intranasal OT is delivered to the brain in humans. Delivering OT using a novel 'Breath Powered' nasal device previously shown to enhance deposition in intranasal sites targeted for nose-to-brain transport, we evaluated dose-dependent effects on social cognition, compared response with intravenous (IV) administration of OT, and assessed nasal cavity dimensions using acoustic rhinometry. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults completing four single-dose treatments (intranasal 8 IU (international units) or 24 IU OT, 1 IU OT IV and placebo). The primary outcome was social cognition measured by emotional ratings of facial images. Secondary outcomes included the pharmacokinetics of OT, vasopressin and cortisol in blood and the association between nasal cavity dimensions and emotional ratings. Despite the fact that all the treatments produced similar plasma OT increases compared with placebo, there was a main effect of treatment on anger ratings of emotionally ambiguous faces. Pairwise comparisons revealed decreased ratings after 8 IU OT in comparison to both placebo and 24 IU OT. In addition, there was an inverse relationship between nasal valve dimensions and anger ratings of ambiguous faces after 8-IU OT treatment. These findings provide support for a direct nose-to-brain effect, independent of blood absorption, of low-dose OT delivered from a Breath Powered device.

  17. Opryszczkowe zapalenie mózgu przebiegające w postaci szybko narastającego zespołu otępiennego u chorej na reumatoidalne zapalenie stawów, leczonej infliksymabem

    Directory of Open Access Journals (Sweden)

    Justyna Swarowska-Knap

    2011-06-01

    Full Text Available Przedstawiono przypadek 53-letniej chorej na reumatoidalnezapalenie stawów (RZS o ciężkim, opornym na standardoweleczenie przebiegu, leczonej wieloma lekami modyfikującymi przebiegchoroby (LMPCh oraz glikokortykosteroidami, u którejw trakcie leczenia antycytokinowego (infliksymabem wystąpiłyobjawy szybko narastającego zespołu otępiennego. Ze względu nacoraz powszechniejsze zastosowanie leków antycytokinowych nietylko w dziedzinie reumatologii, coraz częściej w literaturze światowejpojawiają się doniesienia o związanych z ich stosowaniemdziałaniach niepożądanych, w tym powikłaniach infekcyjnychi zaburzeniach ze strony ośrodkowego układu nerwowego. Zaburzenianeurologiczne obserwowano w trakcie leczenia wszystkimiinhibitorami czynnika martwicy nowotworów α (tumour necrosisfactor α – TNF-α. Wśród nich występowały: parestezje (65% chorych,zaburzenia widzenia związane z zapaleniem nerwu wzrokowego(40% chorych i splątanie (25% chorych. Ponadto, wgdanych literaturowych, u chorych na RZS leczonych immunosupresyjnieistnieje większe niż w populacji ogólnej ryzyko poważnychinfekcji oraz reaktywacji latentnych infekcji wirusowych,w tym infekcji wirusami z rodziny Herpesviridae i wirusem JC. Ze względu na możliwy związek szybko ujawniających się zaburzeńneurologicznych z leczeniem infliksymabem wysunięto u pacjentkipodejrzenie postępującej wieloogniskowej leukoencefalopatii(progressive multifocal leukoencephalopathy – PML, będącej wynikiemaktywacji utajonej infekcji wirusem JC. W wykonanym badaniuMRI mózgowia stwierdzono obecność hiperintensywnychzmian zlokalizowanych w istocie białej oraz szarej płatów czołowychi skroniowych, które nie dawały efektu masy (ryc. 1. Lokalizacjazmian w płatach skroniowych była typowa dla opryszczkowegozapalenia mózgu (herpes simplex encephalitis – HSE, aleobecnie wiadomo, że podobne zmiany mogą także występowaćw PML. Obie neuroinfekcje mogą przebiega

  18. Orthodontic treatment for disabled children: a survey of parents' attitudes and overall satisfaction.

    Science.gov (United States)

    Abeleira, María Teresa; Pazos, Elisabeth; Ramos, Isabel; Outumuro, Mercedes; Limeres, Jacobo; Seoane-Romero, Juan; Diniz, Marcio; Diz, Pedro

    2014-08-05

    Many patients with disability require orthodontic treatment (OT) to achieve adequate oral function and aesthetic appearance. The cooperation of disabled patients and of their parents is central to the success of OT, as treatment can involve ethical dilemmas. The aim of this study was to analyze the motivation, expectations and overall satisfaction with OT among parents of patients with disabilities. The parents of 60 disabled Spanish children with physical, mental and/or sensory impairment undergoing OT were surveyed on attitudes to OT and level of satisfaction with the outcomes. The survey consisted of 23 questions in 4 sections: attitude and adaptation, benefits, adverse effects, and level of satisfaction after completion of OT. A control group formed of the parents of 60 healthy children undergoing OT at the same institution were also surveyed. Parents of disabled children undergoing OT showed a high level of motivation and they are willing to collaborate in oral hygiene procedures. Adaptation to the removable appliances was poorer in disabled children but adaptation to fixed appliances was excellent. OT can provide a marked improvement in quality of life, social relationships and oral functionality in disabled children. Among parents of disabled children undergoing OT, the perceived level of overall satisfaction was very high and expectations were often exceeded.

  19. Elegantne ja värske Rahvusooper Estonia / Maris Takk

    Index Scriptorium Estoniae

    Takk, Maris

    2006-01-01

    Rahvusooper Estonia publikuruumide renoveerimine. Sisearhitektid Juta Lember ja Aulo Padar, SAB Lember & Padar. Arhitektuurse projekti autor Indrek Suigusaar (AB Pluss). Eesti Sisearhitektide Liidu 2005. a. ajaloolise interjööri preemia. J. Lemberist ja A. Padarist, nende tähtsamad tööd, autasud. Ill.: plaan, 16 värv. vaadet, fotod sisearhitektidest

  20. Kolmanda raamatu kiituseks / Peeter Olesk

    Index Scriptorium Estoniae

    Olesk, Peeter, 1953-

    2009-01-01

    Tutvustus: Isaacson, Walter. Einstein : tema elu ja universum / tõlkinud Matti Piirimaa. Tallinn : Eesti Raamat, 2009; Fortey, Jacqueline. Kuulsad teadlased (Silmaring) / tõlkinud Ülle Haav ja Helen Haav. Tallinn : Koolibri, 2009; Vaim ja aeg (Lehed ja tähed : looduse ja teaduse aastaraamat, 5) / koostanud Indrek Rohtmets ja Toomas Kukk. Tallinn : Loodusajakiri, 2009

  1. Eestit esindab Veneetsia arhitektuuribiennaalil sotsiaalset positsioneerimist käsitlev installatsioon

    Index Scriptorium Estoniae

    2006-01-01

    Veneetsia X arhitektuuribiennaalil "Meta-linn" Eestit esindavaks väljapanekuks valis komisjon (liikmed loetletud) reaalajas toimiva linnaplaneerimise keskkonna projekti. Väljapaneku loovad arhitektuuribüroo Urban Mark (arhitektid Ülar Mark, Kaja Pae, Indrek Tiigi) ja Tartu Ülikooli geograafia instituut (teadurid Rein Ahas, Anto Aasa, Siiri Silm). Ideekonkursile laekus 9 näituseprojekti

  2. Mänguväljak rikastab linnakeskkonda / Karin Bachmann

    Index Scriptorium Estoniae

    Bachmann, Karin, 1976-

    2005-01-01

    Mänguväljakute rajamisest ja korrashoiust Tartus, kus on olemas ülelinnaline mänguväljakute teemaplaneering. Projekt algatati 2002. a., eestvedaja Angela Männiste. Arvamust avaldavad Andres Pool ja Indrek Ranniku Tartu linnavalitsusest. Tallinnal ülelinnaline plaan mänguväljakute rajamiseks puudub, olukorrast Mustamäel ja Nõmmel. 3 ill

  3. Rahumaa võttis Kruuda vastu kasutusele aresti / Lemmi Kann

    Index Scriptorium Estoniae

    Kann, Lemmi

    2008-01-01

    Kohus arestis Oliver Kruuda suurosalusega Kalevi magusatootmise ning Tere piimakombinaadi varad pärast Kalevi ostu proovinud Indrek Rahumaa juhitava Alta Capital Foodsi esitatud vastava sisuga taotlust. Alta Foodsi tehtud 94 miljoni krooni suuruse ettemaksu tagastamise osas langetab vahekohus otsuse 2009. aasta esimesel poolel. Lisa: Kalevi käibevara õhku täis; Kronoloogia

  4. Maja Kloostri Taga Metsas : Padise, Harjumaa = A House in the Woods behind the Monastery : Padise, Harjumaa / Regina Viljasaar

    Index Scriptorium Estoniae

    Viljasaar, Regina

    2003-01-01

    Ümbrusesse sulanduv, konkursil "Eesti parim puitehitis 1997-2002" välislaudise kasutamise preemia saanud eramu. Laudiseks on kasutatud 45-kraadise nurga alla asetatud laudu. Projekteerija: Arhitektuuribüroo Kolde Grupp OÜ. Arhitekt Indrek Allmann, konstruktor Eldor Vare. Projekt 1999, valmis 2003. 3 välisvaadet, sisevaade, I ja II korruse plaan, paigutus asukohta, tsoneering

  5. "Dozhd" v kamne / Jevgeni Ashihmin

    Index Scriptorium Estoniae

    Ashihmin, Jevgeni

    2006-01-01

    Narva vanalinna arheoloogiat ja võimalikku Raekoja platsi äärset hoonestust tutvustav näitus "Kolm linna" Narva linnuses. Narva kolledzhi uue hoone arhitektuurikonkursi võidutööst "Vihm" (arhitektid Katrin Koov, Indrek Peil ja Siiri Vallner). Narva linnajuhtide arvates peaks hoone rohkem sarnanema sõjaeelse börsihoonega, mille kohale kolledzh ehitatakse

  6. Näitus Mahtra talurahvamuuseumi arhitektuurikonkursile laekunud töödest

    Index Scriptorium Estoniae

    2005-01-01

    Võistlustööde hindamiskomisjoni liikmed. Parim töö "Heinamaa", arhitektid Tomomi Hayashi ja Hanno Grossschmidt arhitektuuribüroost HG Arhitektuur. Teine koht Andres Lemberi ja Tarmo Maiste tööle "Talgud", kolmas koht Liina Jaanuse tööle "Pärand", neljas koht Indrek Järve tööle "Part"

  7. Tartu Tervishoiu Kõrgkool = Tartu Health Care College

    Index Scriptorium Estoniae

    2012-01-01

    Eesti Sisearhitektide Liidu 2011. a. ühiskondliku interjööri preemia pälvinud Tartu Tervishoiu Kõrgkooli hoone (Nooruse 5) sisekujundusest. Suurem osa kooli mööblist on tehtud eritellimusel sisearhitekti jooniste järgi. Sisearhitekt Tarmo Piirmets (Pink OÜ). Loetletud Pink OÜ töid. Arhitektid Siiri Vallner ja Indrek Peil

  8. Patarei ja Lennusadama ala planeering = Plan for the Patarei Fort and Lennusadam Port Area

    Index Scriptorium Estoniae

    2007-01-01

    Patarei ja Lennusadama ala mahulise planeerimise rahvusvaheline ideevõistlus 2007. aastal. Võistlustööd "Kolm õuna" (I preemia - Sverre Laanjärv, Ivar Lubjak), "Põhi" (II preemia - Tõnu Laanemäe, Jaak-Adam Looveer, Toomas Paaver, kaasautorid Indrek Järve ja Lauri Saar) ja "Kompass" (III preemia - Ott Kadarik ja Villem Tomiste, AB Kosmos)

  9. Roostetav legomaja / Karen Jagodin ; kommenteerinud Laila Põdra

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2009-01-01

    Betoonelementidest eramu (267 m²) Tabasalus. Arhitekt Laila Põdra, insener Indrek Laul. Sisekujundus: Laila Põdra koos omanikega. Projekt: 2005-2007, valmis: 2008. Betoon on viimistluspinnaks ka interjööris. Läbivaks tooniks sise- ja välisviimistluses on roostepunane, teiseks põhitooniks on valge. Konkursil "Aasta Betoonehitis 2008" pälvis tellija eripreemia

  10. Comprehensive, blinded assessment of balance in orthostatic tremor.

    Science.gov (United States)

    Bhatti, Danish; Thompson, Rebecca; Xia, Yiwen; Hellman, Amy; Schmaderer, Lorene; Suing, Katie; McKune, Jennifer; Penke, Cynthia; Iske, Regan; Roeder, Bobbi Jo; Siu, Ka-Chun; Bertoni, John M; Torres-Russotto, Diego

    2018-02-01

    Orthostatic Tremor (OT) is a movement disorder characterized by a sensation of unsteadiness and tremors in the 13-18 Hz range present upon standing. The pathophysiology of OT is not well understood but there is a relationship between the sensation of instability and leg tremors. Despite the sensation of unsteadiness, OT patients do not fall often and balance in OT has not been formally assessed. We present a prospective blinded study comparing balance assessment in patients with OT versus healthy controls. We prospectively enrolled 34 surface Electromyography (EMG)-confirmed primary OT subjects and 21 healthy controls. Participants underwent evaluations of balance by blinded physical therapists (PT) with standardized, validated, commonly used balance scales and tasks. OT subjects were mostly female (30/34, 88%) and controls were majority males (13/20, 65%). The average age of OT subjects was 68.5 years (range 54-87) and for controls was 69.4 (range 32-86). The average duration of OT symptoms was 18 years. OT subjects did significantly worse on all the balance scales and on most balance tasks including Berg Balance Scale, Functional Gait Assessment, Dynamic Gait Index, Unipedal Stance Test, Functional Reach Test and pull test. Gait speed and five times sit to stand were normal in OT. Common validated balance scales are significantly abnormal in primary OT. Despite the objective finding of impaired balance, OT patients do not commonly have falls. The reported sensation of unsteadiness in this patient population seems to be out of proportion to the number of actual falls. Further studies are needed to determine which components of commonly used balance scales are affected by a sensation of unsteadiness and fear of falling. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Some historic and current aspects of plasma diagnostics using atomic spectroscopy

    Science.gov (United States)

    Hutton, Roger; Zou, Yaming; Andersson, Martin; Brage, Tomas; Martinson, Indrek

    2010-07-01

    In this paper we give a short introduction to the use of atomic spectroscopy in plasma diagnostics. Both older works and exciting new branches of atomic physics, which have relevance to diagnostics, are discussed. In particular we focus on forbidden lines in Be-like ions, lines sensitive to magnetic fields and levels which have a lifetime dependence on the nuclear spin of the ion, i.e. f-dependent lifetimes. Finally we mention a few examples of where tokamaks, instead of needing atomic data, actually provide new data and lead to developments in atomic structure studies. This paper is dedicated to the memory of Nicol J Peacock (1931-2008), a distinguished plasma scientist who contributed much to the field of spectroscopy applied to plasma, and in particular, fusion plasma diagnostics. During the final stages of the preparation of this paper Professor Indrek Martinson passed away peacefully in his sleep on 14 November 2009. Indrek will be greatly missed by many people, both for his contributions to atomic spectroscopy and for his great kindness and friendliness, which many of us experienced.

  12. Association of Oxytocin and Parental Prefrontal Activation during Reunion with Infant: A Functional Near-Infrared Spectroscopy Study

    Directory of Open Access Journals (Sweden)

    Jun Ito

    2017-12-01

    Full Text Available Although previous studies have revealed the role of oxytocin (OT in parental behavior, the role of OT has not been investigated through the direct assessment of prefrontal brain activation during parenting. By using functional near-infrared spectroscopy, we aimed to show the relationship between parental [maternal (N = 15 and paternal (N = 21] OT levels and the activation of the prefrontal cortex (PFC, while holding their infants after separation. Baseline OT levels were measured in the subjects’ saliva samples before the experiment. Prefrontal brain activation was assessed in participants sitting alone on a chair (i.e., separation from their infant for 120 s and during the target period (i.e., holding their infant for 45 s, which was done in triplicate. The oxygen hemoglobin (oxy-Hb dissociation curve significantly increased in 9 out of 22 channels on the PFC when maternal and paternal samples were combined. However, only the fathers showed a correlation between salivary OT and oxy-Hb signal. Furthermore, while holding their infants, high-OT fathers showed left hemispheric dominance compared to low-OT fathers, while high-OT mothers showed right hemispheric dominance compared to low-OT mothers. This study showed that fathers with high-OT levels showed neural activation with left hemispheric dominance, while holding their infants, suggesting that increase of OT level might activate paternal PFC related to parenting behavior, although the same is not true for mothers.

  13. The acute effects of intranasal oxytocin administration on endocrine and sexual function in males.

    Science.gov (United States)

    Burri, Andrea; Heinrichs, Markus; Schedlowski, Manfred; Kruger, Tillmann H C

    2008-06-01

    The role of the neuropeptide oxytocin (OT) ranges from the modulation of neuroendocrine physiological effects to the establishment of complex social and bonding behaviours. Experimental studies in animals, as well as case reports in humans, suggest that OT affects different aspects of sexual behaviour and has predominantly facilitating properties for sexual appetence and performance. Using a previously established experimental paradigm of sexual arousal and masturbation-induced orgasm, this study investigated the acute effects of intranasal OT application (24I.U.) on endocrine parameters and measures of sexual appetence and function in healthy men (n=10). In a double-blind, placebo-controlled, balanced cross-over design, sexual arousal, and orgasm were induced by an erotic film and masturbation. In addition to the continuous recording of endocrine (OT, cortisol, prolactin, epinephrine, norepinephrine) and cardiovascular data (heart rate), parameters of appetitive, consummatory, and refractory sexual behaviour were assessed using the acute sexual experience scale (ASES). OT plasma levels were significantly elevated after intranasal OT throughout the whole experiment (>60 min). In addition, OT treatment induced significantly higher increases in epinephrine plasma levels during sexual activity without affecting cortisol levels, prolactin levels or heart rate. OT treatment did not alter appetitive, consummatory, and refractory sexual behaviour according to the ASES. However, when subjects were asked about their subjective perception of whether OT or placebo had been applied, eight out of 10 subjects in the OT group answered correctly, thus pointing to an altered perception of arousal. In conclusion, intranasally administered OT leads to a marked increase in OT plasma levels together with increased secretion of catecholamines when subjects are engaged in sexual activity in a laboratory setting. As the effects of OT on sexual behaviour were equivocal, future studies

  14. Distinct BOLD activation profiles following central and peripheral oxytocin administration in awake rats

    Directory of Open Access Journals (Sweden)

    Craig F Ferris

    2015-09-01

    Full Text Available A growing body of literature has suggested that intranasal oxytocin (OT or other systemic routes of administration can alter prosocial behavior, presumably by directly activating OT sensitive neural circuits in the brain. Yet there is no clear evidence that OT given peripherally can cross the blood-brain-barrier at levels sufficient to engage the OT receptor. To address this issue we examined changes in blood oxygen level dependent (BOLD signal intensity in response to peripheral OT injections (0.1, 0.5 or 2.5 mg/kg during functional magnetic resonance (fMRI in awake rats imaged at 7.0 tesla. These data were compared to OT (1ug/5 µl given directly to the brain via the lateral cerebroventricle. Using a 3D annotated MRI atlas of the rat brain segmented into 171 brain areas and computational analysis we reconstructed the distributed integrated neural circuits identified with BOLD fMRI following central and peripheral OT. Both routes of administration caused significant changes in BOLD signal within the first 10 min of administration. As expected, central OT activated a majority of brain areas known to express a high density of OT receptors e.g., lateral septum, subiculum, shell of the accumbens, bed nucleus of the stria terminalis. This profile of activation was not matched by peripheral OT. The change in BOLD signal to peripheral OT did not show any discernible dose-response. Interestingly, peripheral OT affected all subdivisions of the olfactory bulb, in addition to the cerebellum and several brainstem areas relevant to the autonomic nervous system, including the solitary tract nucleus. The results from this imaging study do not support a direct central action of peripheral OT on the brain. Instead, the patterns of brain activity suggest that peripheral OT may interact at the level of the olfactory bulb and through sensory afferents from the autonomic nervous system to influence brain activity.

  15. Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake.

    Science.gov (United States)

    Herisson, F M; Waas, J R; Fredriksson, R; Schiöth, H B; Levine, A S; Olszewski, P K

    2016-04-01

    Central oxytocin (OT) promotes feeding termination in response to homeostatic challenges, such as excessive stomach distension, salt loading and toxicity. OT has also been proposed to affect feeding reward by decreasing the consumption of palatable carbohydrates and sweet tastants. Because the OT receptor (OTR) is expressed in the nucleus accumbens core (AcbC) and shell (AcbSh), a site regulating diverse aspects of eating behaviour, we investigated whether OT acts there to affect appetite in rats. First, we examined whether direct AcbC and AcbSh OT injections affect hunger- and palatability-driven consumption. We found that only AcbC OT infusions decrease deprivation-induced chow intake and reduce the consumption of palatable sucrose and saccharin solutions in nondeprived animals. These effects were abolished by pretreatment with an OTR antagonist, L-368,899, injected in the same site. AcbC OT at an anorexigenic dose did not induce a conditioned taste aversion, which indicates that AcbC OT-driven anorexia is not caused by sickness/malaise. The appetite-specific effect of AcbC OT is supported by the real-time polymerase chain reaction analysis of OTR mRNA in the AcbC, which revealed that food deprivation elevates OTR mRNA expression, whereas saccharin solution intake decreases OTR transcript levels. We also used c-Fos immunohistochemistry as a marker of neuronal activation and found that AcbC OT injection increases activation of the AcbC itself, as well as of two feeding-related sites: the hypothalamic paraventricular and supraoptic nuclei. Finally, considering the fact that OT plays a significant role in social behaviour, we examined whether offering animals a meal in a social setting would modify their hypophagic response to AcbC OT injections. We found that a social context abolishes the anorexigenic effects of AcbC OT. We conclude that OT acting via the AcbC decreases food intake driven by hunger and reward in rats offered a meal in a nonsocial setting. © 2016

  16. Distinct BOLD Activation Profiles Following Central and Peripheral Oxytocin Administration in Awake Rats.

    Science.gov (United States)

    Ferris, Craig F; Yee, Jason R; Kenkel, William M; Dumais, Kelly Marie; Moore, Kelsey; Veenema, Alexa H; Kulkarni, Praveen; Perkybile, Allison M; Carter, C Sue

    2015-01-01

    A growing body of literature has suggested that intranasal oxytocin (OT) or other systemic routes of administration can alter prosocial behavior, presumably by directly activating OT sensitive neural circuits in the brain. Yet there is no clear evidence that OT given peripherally can cross the blood-brain barrier at levels sufficient to engage the OT receptor. To address this issue we examined changes in blood oxygen level-dependent (BOLD) signal intensity in response to peripheral OT injections (0.1, 0.5, or 2.5 mg/kg) during functional magnetic resonance imaging (fMRI) in awake rats imaged at 7.0 T. These data were compared to OT (1 μg/5 μl) given directly to the brain via the lateral cerebroventricle. Using a 3D annotated MRI atlas of the rat brain segmented into 171 brain areas and computational analysis, we reconstructed the distributed integrated neural circuits identified with BOLD fMRI following central and peripheral OT. Both routes of administration caused significant changes in BOLD signal within the first 10 min of administration. As expected, central OT activated a majority of brain areas known to express a high density of OT receptors, e.g., lateral septum, subiculum, shell of the accumbens, bed nucleus of the stria terminalis. This profile of activation was not matched by peripheral OT. The change in BOLD signal to peripheral OT did not show any discernible dose-response. Interestingly, peripheral OT affected all subdivisions of the olfactory bulb, in addition to the cerebellum and several brainstem areas relevant to the autonomic nervous system, including the solitary tract nucleus. The results from this imaging study do not support a direct central action of peripheral OT on the brain. Instead, the patterns of brain activity suggest that peripheral OT may interact at the level of the olfactory bulb and through sensory afferents from the autonomic nervous system to influence brain activity.

  17. Developmental toxicity of organotin compounds in animals

    Directory of Open Access Journals (Sweden)

    Lijiao eWu

    2014-09-01

    Full Text Available Organotin compounds (OTs have been used as biocides in antifouling paints and agriculture. The IMO introduced a global ban on the use of OTs in antifouling systems in 2001 due to their high toxicity. However, OTs have still been detected in the environment and pose a threat to the ecosystem. Several research groups have summarized the analytical methods, environmental fate, biochemistry, reproductive toxicity and mechanisms of actions of OTs. Here, we reviewed the developmental toxicity of OTs in various organisms such as sea urchin, ascidian, mussel and fish. The differences in sensitivity to OT exposure exist not only in different species but also at different stages in the same species. Though some hypotheses have been proposed to explain the developmental toxicity of OTs, the solid evidences are greatly in need.

  18. Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol.

    Science.gov (United States)

    Yuen, Kaeli W; Garner, Joseph P; Carson, Dean S; Keller, Jennifer; Lembke, Anna; Hyde, Shellie A; Kenna, Heather A; Tennakoon, Lakshika; Schatzberg, Alan F; Parker, Karen J

    2014-04-01

    The neuropeptide oxytocin (OT) promotes social behavior and attenuates stress responsivity in mammals. Recent clinical evidence suggests OT concentrations may be dysregulated in major depression. This study extends previous research by testing whether: 1) OT concentrations vary systematically in depressive disorders with and without hypercortisolemia, 2) gender differences in OT concentrations are observed in depressed vs. healthy control participants, and 3) OT concentrations are predictive of clinical phenotypes. Plasma OT concentrations of psychotic major depressive (PMD; n = 14: 10 female, 4 male), non-psychotic major depressive (NPMD; n = 17: 12 female, 5 male), and non-depressed, healthy control (n = 19: 11 female, 8 male) participants were assayed at 2000, 2400, 0400, and 0800 h. Plasma cortisol concentrations were quantified at 2300 h, and clinical phenotypes were determined. As expected, PMD participants, compared to NPMD and healthy control participants, showed higher plasma cortisol concentrations. Although both depressed groups showed similar OT concentrations, a significant interaction effect between group and gender was observed. Specifically, depressed females exhibited lower mean OT concentrations than depressed males. Further, depressed vs. healthy control female participants exhibited lower mean OT concentrations, whereas depressed vs. healthy control male participants showed a trend in the opposite direction. OT concentrations were also predictive of desirability, drug dependence, and compulsivity scores as measured by the Million Clinical Multiaxial Inventory-III. All findings were independent of cortisol. These data suggest that OT signaling may provide a mechanism by which to better understand female-biased risk to develop depressive disorders and that plasma OT concentrations may be a useful biomarker of certain clinical phenotypes. Copyright © 2013. Published by Elsevier Ltd.

  19. Oxytocin mechanisms of stress response and aggression in a territorial finch.

    Science.gov (United States)

    Goodson, James L; Schrock, Sara E; Kingsbury, Marcy A

    2015-03-15

    All jawed vertebrates produce a form of oxytocin (OT), and in birds, mammals and fish, OT is strongly associated with affiliation. However, remarkably few data are available on the roles of OT and OT receptors (OTRs) in aggression. Because OT and OTRs exert anxiolytic effects in mammals (although context-specific) and modulate stress coping, we hypothesized that OTR activation is at least permissive for territorial aggression. Indeed, we find that peripheral injections of an OTR antagonist significantly reduce male-male and female-female aggression in a highly territorial finch. This finding suggests the hypothesis that aggression is accompanied by an increase in transcriptional (Fos) activity of OT neurons, but contrary to this hypothesis, we find that dominant male residents do not elevate OT-Fos colocalization following an aggressive encounter and that OT-Fos colocalization in the preoptic area and hypothalamus correlates negatively with aggression. Furthermore, OT-Fos colocalization increases dramatically in males that were aggressively subjugated or pursued by a human hand, likely reflecting OT modulation of stress response. Because OT inhibits the hypothalamo-pituitary-adrenal axis, the antagonist effects may reflect the fact that aggressive birds and mammals tend to be hyporesponsive to stress. If this is correct, then 1) the observed effects of OTR antagonism may reflect alterations in corticosterone feedback to the brain rather than centrally mediated OTR effects, and 2) the negative correlation between OT-Fos colocalization and aggression may reflect the fact that more aggressive, stress hyporesponsive males require less inhibition of the hypothalamo-pituitary-adrenal axis than do less aggressive males, despite the requirement of that inhibition for the normal display of aggression. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Oxytocin increases amygdala reactivity to threatening scenes in females.

    Science.gov (United States)

    Lischke, Alexander; Gamer, Matthias; Berger, Christoph; Grossmann, Annette; Hauenstein, Karlheinz; Heinrichs, Markus; Herpertz, Sabine C; Domes, Gregor

    2012-09-01

    The neuropeptide oxytocin (OT) is well known for its profound effects on social behavior, which appear to be mediated by an OT-dependent modulation of amygdala activity in the context of social stimuli. In humans, OT decreases amygdala reactivity to threatening faces in males, but enhances amygdala reactivity to similar faces in females, suggesting sex-specific differences in OT-dependent threat-processing. To further explore whether OT generally enhances amygdala-dependent threat-processing in females, we used functional magnetic resonance imaging (fMRI) in a randomized within-subject crossover design to measure amygdala activity in response to threatening and non-threatening scenes in 14 females following intranasal administration of OT or placebo. Participants' eye movements were recorded to investigate whether an OT-dependent modulation of amygdala activity is accompanied by enhanced exploration of salient scene features. Although OT had no effect on participants' gazing behavior, it increased amygdala reactivity to scenes depicting social and non-social threat. In females, OT may, thus, enhance the detection of threatening stimuli in the environment, potentially by interacting with gonadal steroids, such as progesterone and estrogen. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. Oxytocin and Aggression.

    Science.gov (United States)

    de Jong, Trynke R; Neumann, Inga D

    2017-09-02

    The neuropeptide oxytocin (OT) has a solid reputation as a facilitator of social interactions such as parental and pair bonding, trust, and empathy. The many results supporting a pro-social role of OT have generated the hypothesis that impairments in the endogenous OT system may lead to antisocial behavior, most notably social withdrawal or pathological aggression. If this is indeed the case, administration of exogenous OT could be the "serenic" treatment that psychiatrists have for decades been searching for.In the present review, we list and discuss the evidence for an endogenous "hypo-oxytocinergic state" underlying aggressive and antisocial behavior, derived from both animal and human studies. We furthermore examine the reported effects of synthetic OT administration on aggression in rodents and humans.Although the scientific findings listed in this review support, in broad lines, the link between a down-regulated or impaired OT system activity and increased aggression, the anti-aggressive effects of synthetic OT are less straightforward and require further research. The rather complex picture that emerges adds to the ongoing debate questioning the unidirectional pro-social role of OT, as well as the strength of the effects of intranasal OT administration in humans.

  2. The knowledge and attitudes of orthodontic trainees towards orthodontic therapists: a national survey.

    Science.gov (United States)

    Patel, Sameer; Mack, Gavin

    2017-09-01

    To assess the knowledge and attitudes of orthodontic trainees towards orthodontic therapists (OTs) in the UK. Cross-sectional survey. UK-based orthodontic trainees. An electronic survey was sent to all members of the Training Grades Group of the British Orthodontic Society assessing exposure to OTs and their knowledge regarding current supervision guidelines and scope of practice. Attitudes towards OTs were also explored. Seventy-six responses (response rate 57%) were returned. Nearly 90% of trainees had no formal training regarding OTs. A total of 15.5% were aware of the correct current supervision guidelines and there was large variation in the knowledge of OTs' scope of practice. The majority of trainees were happy to supervise OTs, but only 22.4% felt prepared for this during training. In total, 63% of trainees felt that OTs could impact their own future job prospects. Currently, there is minimal formal training provided to trainees regarding the role of OTs. This is reflected in the lack of knowledge regarding supervision guidelines and scope of practice. Overall, trainees felt OTs were positive for the workforce but were concerned regarding the impact of their own future employment.

  3. [14.-15. juulini toimus Aegviidu lähistel Mustjõe kõrtsitalus Estcon 2001. Tehti teatavaks ka Stalkeri laureaadid

    Index Scriptorium Estoniae

    2001-01-01

    Stalkeri laureaadid: parim romaan - Orson Scott Card. Enderi mäng (Varrak); parim kogumik - Ray Bradbury. Kaleidoskoop (Varrak); parim tõlkejutt - Michael Moorcock. Unelev linn (ilmunud kogumikus "Valge hundi saatus", Fantaasia); parim algupärane jutustus - Indrek Hargla. Sindbadi kaheksas reis (Algernon, dets. 2000); parim algupärane lühijutt - Karen Orlau. Rannahiidsed (Mardus, 2000, nr. 3)

  4. Летняя кухня - функционально и красиво / Тийна Кольк

    Index Scriptorium Estoniae

    Кольк, Тийна

    2010-01-01

    Valik arhitektuurikonkursile "Väike 2007-2009" esitatud väikeobjektidest. Korvamäe suveköök (Urmas Muru, Peeter Pere, Reet Viigipuu, Karl Õiger), Mähe puhkemaja väliköök (Emil Urbel, Indrek Erm), aiamaja Pelgulinnas (Madis Eek), Suurupi aiapaviljon (Peep Roosmann), Tabasalu vaskeramu grillikoht (Urmas Muru, Peeter Pere, Anna-Maria Erik, Ago Kuddu)

  5. Grillipaviljon, väliköök, varjualune... / Tiina Kolk

    Index Scriptorium Estoniae

    Kolk, Tiina

    2010-01-01

    Tutvustatakse valikut arhitektuurikonkursile "Väike 2007-2009" esitatud õueobjektidest. Suurupi aiapaviljon (Peep Roosmann), aiamaja Pelgulinnas (Madis Eek), Mähe puhkemaja väliköök (Emil Urbel, Indrek Erm), Korvamäe suveköök (Urmas Muru, Peeter Pere, Reet Viigipuu, Karl Õiger), Tabasalu vaskeramu grillikoht (Urmas Muru, Peeter Pere, Anna-Maria Erik, Ago Kuddu)

  6. Euroopa arhitektuuriauhind Rafael Moneole / Ingrid Lillemägi

    Index Scriptorium Estoniae

    Lillemägi, Ingrid

    2001-01-01

    2001. a. Mies van der Rohe preemia võitjad: peapreemia - hispaania arhitekt Rafael Moneo, noore arhitekti preemia - saksa arhitekt Florian Nagler. Eestist esitati preemia saamiseks De la Gardie' kaubamaja (Andres Alver, Tiit Trummal, Tarmo Laht), Rocca al Mare koolimaja (Emil Urbel, Indrek Erm, Ülo Peil, Taso Mähar) ja elamud Suurupis (Urmas Muru, Peeter Pere). 1 ill

  7. Au tööle / Andreas Trossek, Margus Tamm

    Index Scriptorium Estoniae

    Trossek, Andreas, 1980-

    2009-01-01

    Vastuseks Mari Laanemetsa ja Indrek Sirkli artiklike "Elu on läinud paremaks, elu on läinud lõbusamaks ...?" (Sirp, 2009, 31. 07, lk. 18-19) Eesti kunsti ja visuaalkultuuri ajakirja "Kunst.ee" 2009. aasta nr. 1-2 sisu ja kujunduse kohta. Ajakirja uus toimetus: Andreas Trossek - peatoimetaja, Heie Treier, Ave Randviir, kujundaja Margus Tamm

  8. Vaskvilla seinasuuruste akendega / Jana Rand

    Index Scriptorium Estoniae

    Rand, Jana, 1963-

    2008-01-01

    Ehitusettevõtja Indrek Klampe perekonna ebasümmeetriline väljavenitatud viilkatusega villa Võrus. Hoone katus läheb sujuvalt üle seinteks. Arhitekt Karmo Tõra. Sisearhitekt Hillar Mänd. Mööbel tehti eritellimusel firmas Mipla, pehme mööbel firmas Mang. I ja II korruse plaan, 5 värv. välis- ja 7 sisevaadet

  9. Interventsiooni paratamatus kaheksa aastat hiljem = The Inevitability of Intervention Eight Years Later / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2008-01-01

    Uue ning vana arhitektuuri koostoimimisest Eestis. Näiteks toodud hotelli "Telegraaf" juurdeehitus (arhitekt Martin Aunin), nelikmaja (AB Kosmos, 2007) Rotermanni kvartalis, Fahle Maja (KOKO Arhitektid, 2002-2006) Tallinnas, Pärnu kesklinna koolide võimla (Kavakava, 2004-2006), TÜ Narva Kolledzhi 2006. a. arhitektuurikonkursi võidutöö (arhitektid Siiri Vallner, Katrin Koov, Indrek Peil). Bibliograafia lk. 19

  10. Crème de la crème / Joel Sang

    Index Scriptorium Estoniae

    Sang, Joel, 1950-

    2011-01-01

    Auhinnažürii esimees iseloomustab Eesti Kultuurkapitali kirjandusauhindade laureaate: Indrek Koff (luule), Maarja Kangro (proosa), Urmas Vadi (näitekirjandus), Toomas Haug (esseistika), Lauri Sommer (vabaauhind), Amar Annus (ilukirjanduslik tõlge võõrkeelest eesti keelde), Ilmar Lehtpere (ilukirjanduslik tõlge eesti keelest võõrkeelde), Kristiina Kass (lastekirjandus), Sergei Issakov (venekeelse autori kirjandusauhind) ja Mart Velsker (artikliauhind)

  11. Vaba mõtte filmid / Raimo Jõerand

    Index Scriptorium Estoniae

    Jõerand, Raimo, 1970-

    2009-01-01

    Lähima poole aasta jooksul esilinastuvatest Eesti dokumentaalfilmidest : Peeter Brambati "Kosmos'68", Jaan Tootseni-Jaak Kilmi "Uus maailm", Juri Hatšavatski-Marianna Kaati "Ajuoperatsioon", Ilmar Raagi-Kiur Aarma "September", Marianne Kõrveri "7 motiivi", Kristiina Davidjantsi "Palusalu", Liina Triškina-Indrek Treufeldti "1939", Mihkel Kärmase-Rasmus Kagge "Riigireetur", Artur Talviku "Baruto - tõlkes kaduma läinud"

  12. Dave Benton laulab Peetri kirikus / Arvo Uustalu

    Index Scriptorium Estoniae

    Uustalu, Arvo, 1964-

    2004-01-01

    Poplaulja Dave Bentoni ja Eesti Televisiooni lastekoori kontserdist 20. dets. Tartu Peetri kirikus. Peetri kirikus heategevuskontserdil "Tee rõõmsaks mind, kui sul on aega" 28. dets. laulavad Katrin Pärn, Toomas Lunge, Kait Tamra ja Indrek Kalda. Rein Rannapi viisistatud kantaati "Ilus maa" esitab Kadri Leppoja juhatusel ja Urmas Taniloo saatel M. Härma gümnaasiumi segakoor

  13. Mahtra Talurahvamuuseum

    Index Scriptorium Estoniae

    2005-01-01

    Mahtra Talurahvamuuseumi eskiisprojekti võistluse eesmärgiks oli saada parim lahendus muuseumihoone kaasajastamiseks ja laiendamiseks. Žürii koosseis. Võidutööst. Preemiad: I - Tomomi Hayashi, Hanno Grossschmidt ((HG Arhitektuur), II - Andres Lember, Tarmo Maiste (Male Arhitektid), III - Liina Jaanus, ergutuspreemia - Indrek Järve (Schults ja Partnerid). Ill.: võidutöö asendiplaan, korruste plaanid, vaade

  14. Torontos peeti eesti dokfilmifestivali "Estdoc's" / Olev Remsu

    Index Scriptorium Estoniae

    Remsu, Olev, 1947-

    2006-01-01

    Toronto eesti dokumentaalfilmide festival "Estdoc's". Demonstreeriti filme: "Sinimäed" (Raimo Jõerand), "Tiim" (Peep Puks), "Mikk" (Rein Raamat, Peeter Brambat), "6 tundi" (Rein Kotov), "Erna retk" (Vaado Sarapuu), "Tõrjutud mälestused" (Imbi Paju), "Middendorfi jälgedes" (Riho Västrik), "Mehed unustatud armeest" (Indrek Treufeldt), "Nagu noor jumal" ja "Orjus Eestis" (mõlema autor Olev Remsu)

  15. Top 10 Estonian albums of 2004 / Igor Garshnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2004-01-01

    Heliplaatidest: Arvo Pärt "Pro et contra", Various composers "Baltic Voices 2", Raimo Kangro "Displays", Toivo Tulev "Be Lost in the Call", Indrek Vau and Mati Mikalai "Estonian Trumpet Music", Erdmann/Sooäär "Dessert Time, Peer Gynt & Other Stories", Alo Mattiisen "50 parimat laulu", Riho Sibul "Must", Rein Rannap "Tantsib klaveril", Eesti Keeled "Kella tiksumist..."

  16. [Literaturwerkstatt Berlin`i loodud ja koordineeritud rahvusvaheline kaasaegse luule portaal

    Index Scriptorium Estoniae

    2014-01-01

    42 riigi kirjandusorganisatsioonide ühistöö varal täienevas kaasaegse luule portaalis http://www.lyrikline.org saab kuulata ja lugeda 1000 luuletaja loomingut ja neist 11 on eesti autorid: Elo Viiding, Maarja Kangro, Jürgen Rooste, Birk Rohelend, Kaur Riismaa, Indrek Mesikepp, Maria Lee, Asko Künnap, Hasso Krull, Veronika Kivisilla ja Igor Kotjuh

  17. Rapsist diislikütus : kallis ja tõrjutud / Heiki Raudla

    Index Scriptorium Estoniae

    Raudla, Heiki, 1975-

    2008-01-01

    Paldiski Lõunasadamas avatud Biodiesel Paldiski AS tehas loodab tulevikus täisvõimsuse juures toota 100 000 tonni biodiislikütust aastas, praegu eksporditakse kogu toodang peamiselt Lääne-Euroopasse ja Skandinaaviasse. Eesti tarbijale biodiislikütuse tootmist takistab peamiselt tooraine kõrge hind ning vähene nõudlus. Küsimusele vastavad Kai Realo ja Indrek Kaju

  18. Tallinki esimene börsipäev pettis väikeinvestorite ootusi / Hindrek Riikoja

    Index Scriptorium Estoniae

    Riikoja, Hindrek

    2005-01-01

    Tallinki aktsia esimene börsipäev valmistas paljudele väikeinvestoritele pettumust, kuna aktsia hind tõusis päevaga vaid 58 senti ehk 0,7 protsenti. Lisa: Kas teate? Küsimusele, mida teete Tallinki aktsiatega, vastavad: ettevõtja Indrek Toome, Riigikogu liige Margus Hanson, teleprodutsent Raivo Suviste ja AS-i Biodiesel nõukogu esimees Heino Harak

  19. Videokunst pärast videokunsti : Pärnu filmi- ja videofestival detsembris 2009 / Raivo Kelomees

    Index Scriptorium Estoniae

    Kelomees, Raivo, 1960-

    2010-01-01

    15. Pärnu filmi- ja videofestival 2009 Port Artur 2 kaubanduskeskuses. Esitatud tööde autorid loetletud. 5. 12. 2009 toimunud rahvusvahelisest konverentsist "Videokunst pärast videokunsti", kus arutleti video nüüdisaegse olukorra üle. Al Paldroki, Raivo Kelomehe, Teijo Pellineni (Soome), Chris Halesi (Inglismaa), Indrek Grigori, Silja Saarepuu ja Hans-Gunter Locki mõtteavaldustest

  20. Matrjoshki ot kutjur

    Index Scriptorium Estoniae

    2008-01-01

    Vene moeajakirja Vogue kümnendaks juubeliks joonistasid tuntud moekunstnikud kogu maailmast matrjoshkade eskiise. Eskiiside järgi maalisid vene meistrid poolemeetrised nukud. Nii sai ajakiri kingituseks Yves Saint Laurent'i, Versace, Prada, Dolce&Gabbana, Oscar de la Renta, Judashkini, Simatshovi ja paljude teiste matrjoshkad

  1. Dissociating frontal regions that co-lateralize with different ventral occipitotemporal regions during word processing☆

    Science.gov (United States)

    Seghier, Mohamed L.; Price, Cathy J.

    2013-01-01

    The ventral occipitotemporal sulcus (vOT) sustains strong interactions with the inferior frontal cortex during word processing. Consequently, activation in both regions co-lateralize towards the same hemisphere in healthy subjects. Because the determinants of lateralisation differ across posterior, middle and anterior vOT subregions, we investigated whether lateralisation in different inferior frontal regions would co-vary with lateralisation in the three different vOT subregions. A whole brain analysis found that, during semantic decisions on written words, laterality covaried in (1) posterior vOT and the precentral gyrus; (2) middle vOT and the pars opercularis, pars triangularis, and supramarginal gyrus; and (3) anterior vOT and the pars orbitalis, middle frontal gyrus and thalamus. These findings increase the spatial resolution of our understanding of how vOT interacts with other brain areas during semantic categorisation on words. PMID:23728081

  2. Neuropeptide diversity and the regulation of social behavior in New World primates

    Science.gov (United States)

    French, Jeffrey A.; Taylor, Jack H.; Mustoe, Aaryn C.; Cavanaugh, Jon

    2016-01-01

    Oxytocin (OT) and vasopressin (AVP) are important hypothalamic neuropeptides that regulate peripheral physiology, and have emerged as important modulators of brain function, particularly in the social realm. OT structure and the genes that ultimately determine structure are highly conserved among diverse eutherian mammals, but recent discoveries have identified surprising variability in OT and peptide structure in New World monkeys (NWM), with five new OT variants identified to date. This review explores these new findings in light of comparative OT/AVP ligand evolution, documents coevolutionary changes in the oxytocin and vasopressin receptors (OTR and V1aR), and highlights the distribution of neuropeptidergic neurons and receptors in the primate brain. Finally, the behavioral consequences of OT and AVP in regulating NWM sociality are summarized, demonstrating important neuromodulatory effects of these compounds and OT ligand-specific influences in certain social domains. PMID:27020799

  3. Oxytocin--its role in male reproduction and new potential therapeutic uses.

    Science.gov (United States)

    Thackare, Hemlata; Nicholson, Helen D; Whittington, Kate

    2006-01-01

    Oxytocin (OT) is traditionally thought of as a "female" neurohypophysis hormone due to its role in parturition and milk ejection. However, OT is recognized as having endocrine and paracrine roles in male reproduction. At ejaculation, a burst of OT is released from the neurohypophysis into the systemic circulation and stimulates contractions of the reproductive tract aiding sperm release. There is conclusive evidence that OT is synthesized within the mammalian testis, epididymis and prostate and the presence of OT receptors (OTRs) through the reproductive tract supports a local action for this peptide. OT has a paracrine role in stimulating contractility of the seminiferous tubules, epididymis and the prostate gland. Interestingly, OT has also been shown to modulate androgen levels in these tissues via stimulation of the conversion of testosterone to dihydrotestostone (DHT) by 5alpha-reductase. The elucidation of OT's role in male reproduction has suggested a number of potential therapeutic uses for this hormone. Exogenous administration of OT has, in some cases, been shown to increase the numbers of ejaculated sperm, possibly by stimulating contractions of the reproductive tract and thus aiding sperm passage. Within the prostate, OT has been shown to affect gland growth both directly and via its interaction with androgen metabolism. Prostate pathologies due to unregulated cell proliferation/growth, such as benign prostatic hyperplasia and cancer, are unfortunately very common and few effective treatments are available. Greater understanding of paracrine growth mediators, such as OT, is likely to provide new mechanisms for treating such pathologies.

  4. An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism.

    Science.gov (United States)

    Meziane, Hamid; Schaller, Fabienne; Bauer, Sylvian; Villard, Claude; Matarazzo, Valery; Riet, Fabrice; Guillon, Gilles; Lafitte, Daniel; Desarmenien, Michel G; Tauber, Maithé; Muscatelli, Françoise

    2015-07-15

    Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice, and to test the curative effect of a peripheral OT treatment just after birth. We assessed the social and cognitive behavior of Magel2-deficient mice, analyzed the OT system of mutant mice treated or not by a postnatal administration of OT, and determined the effect of this treatment on the brain. Magel2 inactivation induces a deficit in social recognition and social interaction and a reduced learning ability in adult male mice. In these mice, we reveal anatomical and functional modifications of the OT system and show that these defects change from birth to adulthood. Daily administration of OT in the first postnatal week was sufficient to prevent deficits in social behavior and learning abilities in adult mutant male mice. We show that this OT treatment partly restores a normal OT system. Thus, we report that an alteration of the OT system around birth has long-term consequences on behavior and on cognition. Importantly, an acute OT treatment of Magel2-deficient pups has a curative effect. Our study reveals that OT plays a crucial role in setting social behaviors during a period just after birth. An early OT treatment in this critical period could be a novel therapeutic approach for the treatment of neurodevelopmental disorders such as Prader-Willi syndrome and autism. Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  5. Concentration of Antifouling Biocides and Metals in Sediment Core Samples in the Northern Part of Hiroshima Bay

    Directory of Open Access Journals (Sweden)

    Noritaka Tsunemasa

    2014-06-01

    Full Text Available Accumulation of Ot alternative antifoulants in sediment is the focus of this research. Much research had been done on surface sediment, but in this report, the accumulation in the sediment core was studied. The Ot alternative antifoulants, Diuron, Sea-Nine211, and Irgarol 1051, and the latter’s degradation product, M1, were investigated in five samples from the northern part of Hiroshima Bay. Ot compounds (tributyltin (TBT and triphenyltin (TPT were also investigated for comparison. In addition, metal (Pb, Cu, Zn, Fe and Mn levels and chronology were measured to better understand what happens after accumulation on the sea floor. It was discovered that Ot alternative antifoulant accumulation characteristics in sediment were like Ot compounds, with the concentration in the sediment core being much higher than surface sediment. The concentration in sediment seems to have been affected by the regulation of Ot compounds in 1990, due to the concentration of Ot alternative antifoulants and Ot compounds at the survey point in front of the dock, showing an increase from almost the same layer after the regulation.

  6. [Interdisciplinary teamwork in the OR: Identification and measurement of teamwork in the operating room].

    Science.gov (United States)

    Passauer-Baierl, Stefanie; Baschnegger, Heiko; Bruns, Christiane; Weigl, Matthias

    2014-01-01

    Effective teamwork is one of the essentials in conducting successful and safe surgical procedures in the operating theatre (OT). The present paper aims to provide a selective review of various approaches describing effective interdisciplinary teamwork in the OT. Furthermore, it covers observational methods to assess OT teamwork with particular focus on Germany. Our definition of successful surgical teamwork is based on an already established classification system considering five criteria for effective and safe OT teams: coordination, communication, cooperation, leadership, and team monitoring. Well-defined and reliable measures are necessary to examine the quality of OT teamwork. Those methods should entail the special characteristics of the OT team. They should include all phases of the surgical procedure and incorporate all the professions involved (surgeons, surgical nurses, and anaesthetic staff). We conclude that research into methods for the assessment of OTs in Germany needs to be undertaken as a prerequisite to investigating the relationship between OT teamwork and its effects on patient safety and surgical quality. Copyright © 2013. Published by Elsevier GmbH.

  7. Sex, Receptors and Attachment: A Review of Individual Factors Influencing Response to Oxytocin

    Directory of Open Access Journals (Sweden)

    Kai S Macdonald

    2013-01-01

    Full Text Available As discussed in the larger review in this special issue (MacDonald and Feifel, intranasal oxytocin (IN OT is demonstrating a growing potential as a therapeutic agent in psychiatry. Importantly, research suggests that a variety of individual factors may influence a person’s response to OT. In this mini-review, I provides a review of three: (1 sex and hormonal status; (2 genetic variation in aspects of the OT system (i.e. OT receptors; and (3 attachment history. Each of these factors will be important to monitor as we strive to develop a richer understanding of OT's role in human development, brain-based disease, and the potential for individualized, OT-targeted treatments.

  8. A determination of occlusal plane comparing different levels of the tragus to form ala-tragal line or Camper's line: A photographic study.

    Science.gov (United States)

    Kumar, Sandeep; Garg, Sandeep; Gupta, Seema

    2013-02-01

    The purpose of this study was to determine accurately the part of the tragus to be used to form the Ala-Tragal line or Camper's line in orthognathic profile patients. 150 dentate subjects with age of 18-40 years with orthognathic profile were sampled. Life-size lateral digital photographs of the face with fox plane were taken in natural head position. Different angles between Eye-Ear plane and occlusal plane (OT1-OP), Eye-Ear plane and ala-superior border of tragus (OT1-AT1), Eye-Ear plane and ala-middle border of tragus (OT1-AT2) and Eye-Ear plane and ala-inferior border of tragus (OT1-AT3) were calculated using computer software package, AutoCAD 2004. From the three angles formed by the Eye-ear plane (OT1 or FH plane) and the ala-tragal lines, the one closest to the angle formed between Eye-Ear plane (OT1) and occlusal plane (OP) was used to determine the occlusal plane of orientation. The obtained results were subjected to ANOVA F test, Tukey's Honestly significant difference test, followed by Karl Pearson coefficient of correlation test. P values of less than 0.05 were taken as statistically significant. The mean of base line angle i.e. OT1-OP angle (11.96 ± 4.36) was found to be close to OT1-AT2 angle (13.67 ± 1.93) and OT1-AT3 angle (10.31 ± 2.03), but OT1-OP angle was found to be more closer to OT1-AT3 angle. Comparison of mean angles showed that OT1-OP angle in both males (11.68) and females (12.51) is close to OT1-AT3 angle (males- 11.01, females- 11.95). The line joining from ala to the lower border of the tragus was parallel to the occlusal plane in 53.3% of the subjects. There was no influence of the sex on the level of occlusal plane.

  9. Ahnus, ebapädevus, ignorantsus / Indrek Veiserik

    Index Scriptorium Estoniae

    Veiserik, Indrek

    2008-01-01

    Euroopa Parlamendi liikme Ashley Moteþi käsitlusi Euroopa Komisjoni asepresidendi Siim Kallasega seotud 10 miljoni dollari afääri kohta. Vt. samas: intervjuud: Ashley Mote: Kallas sai ametisse salaleppe tulemusel; Pada sõimab katelt; Kas Mart Laari ja Siim Kallast ähvardab suur skandaal? Ettevõtted kaebasid Vabariigi Valitsuse kohtusse

  10. Monoliitne või amorfne Eesti? / Indrek Grigor

    Index Scriptorium Estoniae

    Grigor, Indrek

    2008-01-01

    Eesti Vabariigi 90. sünnipäeva tähistav näitus "Kas me sellist Eestit tahtsime?!" Rael Artel Gallery's Tartus kuni 8. III. Kristina Normani, Flo Kasearu, Merilyn Püssi, Katrin Sarapuu, Eva Labotkini, Taavi Piibemanni ja Tanja Muravskaja töödest

  11. Võrguäri Eestis kiratseb / Indrek Kald

    Index Scriptorium Estoniae

    Kald, Indrek, 1974-

    2004-01-01

    Autor otsib põhjusi, miks tänavuse Interneti-kaupluste edetabeli koostamiseks saatis oma äritulemused vaid viis võrgukauplust. Zebra Infosüsteemide tegevjuhi Peeter Tamme arvamus e-äri kiratsemise põhjuste kohta

  12. Lühiajaline. Suuremõõtmeline / Indrek Grigor

    Index Scriptorium Estoniae

    Grigor, Indrek

    2010-01-01

    3. septembril 2010 avati Eesti Rahva Muuseumi Raadi mõisapargis skulptuurinäitus töödest, mis valmisid rahvusvahelise skulptuurisümpoosioni "Lühiajaline. Suuremõõtmeline" (25. 08.-03. 09. 2010) käigus ja mis jäävad parki aastaks. Sümpoosioni peakorraldajad: Jevgeni Zolotko ja Bruno Kadak, osalesid: Uwe Schloen (Saksamaa), Csilla Nagy (Ungari), Gleb Netšvolodov (Inglismaa), Ahti Seppet, Eike Eplik ja Jevgeni Zolotko (Eesti)

  13. Art ist kuku nu ut / Indrek Grigor

    Index Scriptorium Estoniae

    Grigor, Indrek

    2009-01-01

    Tartu kunstikuust "Art ist kuku nu ut", mis toimus 9. jaanuarist 29. veebruarini. Peakorraldaja Kaisa Eiche. Programmist, välireklaamist, kunstinäitustest, Bernard Murigneux' valgusskulptuuridest, Lemmit Kaplinski kunstikriitika töötubade sarjast "Kriitikavabrik"

  14. Pragmaatika kui hea kunsti garant / Indrek Grigor

    Index Scriptorium Estoniae

    Grigor, Indrek, 1981-

    2007-01-01

    Tartu Kõrgema Kunstikooli diplomitöödest: Martti Poomi (S'Poom "Na'Miin") ja Asko Kikkuli (Iconcrash "My Sky") muusikavideotest, Kaisa Eiche teoreetilisest uurimusest "Kultuuritehase vajalikkus ja teostatavus Tartus", Carl-Christian Frey animafilmist "Pärastlõuna", Andrus Lauringsoni installatsioonist "Capaskoop", Berit Talpsepa robootilisest skulptuurist "Superheterodüünvastuvõtt", Eike Epliku installatiivsest skulptuurist "Ma saan aru, et ma ei ole orav", Anna-Stina Treumundi fotoinstallatsioonist "Vaikiv dialoog", Kalev Vapperi sotsiaalkollaazhist "Vapper Kalev lõpetab kooli"

  15. Kohtumine 8645 kolleegiga / Siiri Vallner, Indrek Peil

    Index Scriptorium Estoniae

    Vallner, Siiri, 1972-

    2008-01-01

    29. 06-3. 07 2008 Torinos toimunud Maailma Arhitektide Liidu (UIA) 23. kongressist teemal edastatav arhitektuur (Transmitting Architecture). Eesti osa balti ühisekspositsioonis koosnes Maja aastafilmide (autor Margit Mutso) näitamisest

  16. Hanno Veldi pisiunistus kasvas suurfirmaks / Indrek Kald

    Index Scriptorium Estoniae

    Kald, Indrek, 1974-

    2008-01-01

    Hanno Veldile ja Helgo Äkkele kuuluv firma OÜ Hanhel Tehnika tegeleb väiketraktorite ja mootorrataste müügiga ning ettevõtte motokeskus Velt Motocenter on laienenud mitmesse linna üle Eesti. Hanno Veldist kui motosportlasest. Kommenteerib Helgo Äkke. Vt. samas: Hanno Velt: klienti võlub teenindus; Velt kukub ka arvutimängus

  17. Organotin Exposure and Vertebrate Reproduction: A Review

    Directory of Open Access Journals (Sweden)

    Julia Fernandez Puñal de Araújo

    2018-03-01

    Full Text Available Organotin (OTs compounds are organometallic compounds that are widely used in industry, such as in the manufacture of plastics, pesticides, paints, and others. OTs are released into the environment by anthropogenic actions, leading to contact with aquatic and terrestrial organisms that occur in animal feeding. Although OTs are degraded environmentally, reports have shown the effects of this contamination over the years because it can affect organisms of different trophic levels. OTs act as endocrine-disrupting chemicals (EDCs, which can lead to several abnormalities in organisms. In male animals, OTs decrease the weights of the testis and epididymis and reduce the spermatid count, among other dysfunctions. In female animals, OTs alter the weights of the ovaries and uteri and induce damage to the ovaries. In addition, OTs prevent fetal implantation and reduce mammalian pregnancy rates. OTs cross the placental barrier and accumulate in the placental and fetal tissues. Exposure to OTs in utero leads to the accumulation of lipid droplets in the Sertoli cells and gonocytes of male offspring in addition to inducing early puberty in females. In both genders, this damage is associated with the imbalance of sex hormones and the modulation of the hypothalamic–pituitary–gonadal axis. Here, we report that OTs act as reproductive disruptors in vertebrate studies; among the compounds are tetrabutyltin, tributyltin chloride, tributyltin acetate, triphenyltin chloride, triphenyltin hydroxide, dibutyltin chloride, dibutyltin dichloride, diphenyltin dichloride, monobutyltin, and azocyclotin.

  18. Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord

    Directory of Open Access Journals (Sweden)

    Darbon Pascal

    2009-11-01

    Full Text Available Abstract Background Growing evidence in the literature shows that oxytocin (OT has a strong spinal anti-nociceptive action. Oxytocinergic axons originating from a subpopulation of paraventricular hypothalamic neurons establish synaptic contacts with lamina II interneurons but little is known about the functional role of OT with respect to neuronal firing and excitability. Results Using the patch-clamp technique, we have recorded lamina II interneurons in acute transverse lumbar spinal cord slices of rats (15 to 30 days old and analyzed the OT effects on action potential firing ability. In the current clamp mode, we found that bath application of a selective OT-receptor agonist (TGOT reduced firing in the majority of lamina II interneurons exhibiting a bursting firing profile, but never in those exhibiting a single spike discharge upon depolarization. Interestingly, OT-induced reduction in spike frequency and increase of firing threshold were often observed, leading to a conversion of the firing profile from repetitive and delayed profiles into phasic ones and sometimes further into single spike profile. The observed effects following OT-receptor activation were completely abolished when the OT-receptor agonist was co-applied with a selective OT-receptor antagonist. In current and voltage clamp modes, we show that these changes in firing are strongly controlled by voltage-gated potassium currents. More precisely, transient IA currents and delayed-rectifier currents were reduced in amplitude and transient IA current was predominantly inactivated after OT bath application. Conclusion This effect of OT on the firing profile of lamina II neurons is in good agreement with the antinociceptive and analgesic properties of OT described in vivo.

  19. Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice.

    Science.gov (United States)

    Kosaki, Yutaka; Watanabe, Shigeru

    2016-04-01

    Oxytocin (OT) has been implicated in a variety of mammalian reproductive and social behaviors, and the use of intranasal OT for clinical purposes is on the rise. However, basic actions of OT, including the rewarding or reinforcing properties of the drug, are currently not fully understood. In this study, the authors investigated whether intranasally administered OT has different reinforcing properties for social and nonsocial stimuli and whether such effects are variable between male and female subjects. Conditioned social preference (CSP) and conditioned place preference (CPP) paradigms were used to examine social and nonsocial reinforcing properties of OT. In CSP, the presence of a same-sex unfamiliar conspecific was repeatedly paired with intranasal OT, while a different conspecific was associated with saline. The reinforcing effect of OT was assessed in a postconditioning choice test under a drug-free condition. In CPP, the 2 conspecifics were replaced with nonsocial black and white compartments. The authors found that intranasal OT (12 μg) in females supported the formation of CSP (Experiment 1) but not CPP (Experiment 3). Neither CSP (Experiment 2) nor CPP (Experiment 4) was formed in males. Extended conditioning with higher dose OT (36 μg), however, abolished the initial CSP in females and produced an aversion to the OT-paired stimulus mouse. Experiment 5 indicated that it was the repeated administrations rather than the higher dose that produced the abolition of the original preference. Overall, the current results demonstrate for the first time a sex- and stimulus-dependent reinforcing property of intranasal OT in mice. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  20. Non-orthogonally transitive G2 spike solution

    International Nuclear Information System (INIS)

    Lim, Woei Chet

    2015-01-01

    We generalize the orthogonally transitive (OT) G 2 spike solution to the non-OT G 2 case. This is achieved by applying Geroch’s transformation on a Kasner seed. The new solution contains two more parameters than the OT G 2 spike solution. Unlike the OT G 2 spike solution, the new solution always resolves its spike. (fast track communication)

  1. Investigations of the 0.020-scale 88-OTS Integrated Space Shuttle Vehicle Jet-Plume Model in the NASA/Ames Research Center 11 by11-Foot Unitary Plan Wind Tunnel (IA80). Volume 1

    Science.gov (United States)

    Nichols, M. E.

    1976-01-01

    The results are documented of jet plume effects wind tunnel test of the 0.020-scale 88-OTS launch configuration space shuttle vehicle model in the 11 x 11 foot leg of the NASA/Ames Research Center Unitary Plan Wind Tunnel. This test involved cold gas main propulsion system (MPS) and solid rocket motor (SRB) plume simulations at Mach numbers from 0.6 to 1.4. Integrated vehicle surface pressure distributions, elevon and rudder hinge moments, and wing and vertical tail root bending and torsional moments due to MPS and SRB plume interactions were determined. Nozzle power conditions were controlled per pretest nozzle calibrations. Model angle of attack was varied from -4 deg to +4 deg; model angle of sideslip was varied from -4 deg to +4 deg. Reynolds number was varied for certain test conditions and configurations, with the nominal freestream total pressure being 14.69 psia. Plotted force and pressure data are presented.

  2. AFM investigation of effect of absorbed water layer structure on growth mechanism of octadecyltrichlorosilane self-assembled monolayer on oxidized silicon

    International Nuclear Information System (INIS)

    Li, Shaowei; Zheng, Yanjun; Chen, Changfeng

    2016-01-01

    The growth mechanism of an octadecyltrichlorosilane (OTS) self-assembled monolayer on a silicon oxide surface at various relative humidities has been investigated. Atomic force microscopy images show that excess water may actually hinder the nucleation and growth of OTS islands. A moderate amount of water is favorable for the nucleation and growth of OTS islands in the initial stage; however, the completion of the monolayer is very slow in the final stage. The growth of OTS islands on a low-water-content surface maintains a relatively constant speed and requires the least amount of time. The mobility of water molecules is thought to play an important role in the OTS monolayers, and a low-mobility water layer provides a steady condition for OTS monolayer growth.

  3. Role of oxytocin in improving the welfare of farm animals - A review.

    Science.gov (United States)

    Chen, Siyu; Sato, Shusuke

    2017-04-01

    Recently, increasing attention has been paid to the welfare of farm animals, which have been evaluated using behavioral and physiological measures. However, so far, the measures have almost always been used to estimate poor welfare. In this review, firstly we focus on how oxytocin (OT) relates to positive social behavior, pleasure, and stress tolerance, and second on which management factors stimulate OT release. OT induces maternal and affiliative behaviors and has an anti-stress effect. Further, OT is produced during enjoyable events, and has positive feedback on its own release as well. Therefore, to some extent, the relationship of OT to positive normal behavior was mutually beneficial-heightened OT concentration owing to comfortable rearing conditions induces positive social behavior, which in turn may increase OT concentration. Hence, studies on animal welfare should pay more attention to increasing comfort and the stress tolerance, rather than only focusing on when stress occurs in farm animals.

  4. Vasopressin and Oxytocin Reduce Food Sharing Behavior in Male, but Not Female Marmosets in Family Groups

    Directory of Open Access Journals (Sweden)

    Jack H. Taylor

    2017-07-01

    Full Text Available Oxytocin (OT is critical for lactation and maternal care, but OT and the related nonapeptide vasopressin are important for caregiving behaviors in fathers and alloparents as well. This experiment tested the effects of vasopressin and OT on food sharing in marmoset families. We treated caregivers (parents, siblings with intranasal vasopressin, OT, or saline, and then paired them with the youngest marmoset in the family. Caregivers were given preferred food, and then observed for food sharing and aggressive behavior with young marmosets. OT reduced food sharing from male alloparents to youngest siblings, and fathers that received vasopressin refused to share food with their youngest offspring more often than when treated with OT. Vasopressin increased aggressive vocalizations directed toward potential food recipients in all classes of caregivers. These results indicate that vasopressin and OT do not always enhance prosocial behavior: modulation of food sharing depends on both sex and parental status.

  5. [Määramised

    Index Scriptorium Estoniae

    2006-01-01

    Ametisse määramised: Kaitseliidu ülem major Raivo Lumiste; Maaväe staabi ülem kolonelleitnant Indrek Sirel; Kaitsejõudude peastaabi personaliosakonna ülem kolonelleitnant Vahur Väljamäe; 1. jalaväebrigaadi ülem kolonelleitnant Artur Tiganik; Scoutspataljoni ülem major Aivar Kokka; Kaitseväe peakaplan major Taavi Laanepere. Haridus, sõjaline kvalifikatsioon, teenistuskäik, auastmed, autasud

  6. Kogu vale kliendilojaalsusest / W. Reinartz, V. Kumar

    Index Scriptorium Estoniae

    Reinartz, W.

    2003-01-01

    Autorid leiavad, et ainult lojaalsusele keskendumise asemel tuleks leida meetodeid mõõtmaks lojaalsuse ja kasumlikkuse omavahelist seost, et selle abil määratleda kliendid, kellele rohkem tähelepanu suunata. Kommenteerivad Eda Odenberg; Ain Taube, Ene Raja, Jaan Tamm ja Indrek Randveer. Diagramm ja tabelid: klientide säilitamise hind; kõrge ja madala kasumlikkusega kliendid; lojaalsusstrateegia valimine vastavalt klientide kasumlikkusele.

  7. Suurim kliendiinfo leke kindlustuses / Sten-Aleks Pihlak

    Index Scriptorium Estoniae

    Pihlak, Sten-Aleks

    2008-01-01

    Eesti suurimat kindlustusmaaklerit Iizi kahtlustatakse koos IT-arendusfirmaga Indium Eesti kindlustusturu suurimas infolekkes. Vt. samas: Intervjuu OÜ Indium juhi Indrek Soomestega. IT-mees: minul oli väike osa; kommenteerivad Sergei Vahnitski, Risto Rossar, Enn Saar; Algis Suik. Lisa: Infolekke skeem; Kuidas sündmused arenesid. Vt. lisaks: IIZI kindlustusfirmal lasub kahtlus. Algatati kriminaalmenetlus. Äripäev 16. juuli lk. 11

  8. Eesti Meremuuseumi hoone Lennusadamas = Estonian Maritime Museum in the Tallinn Seaplane Harbour

    Index Scriptorium Estoniae

    2015-01-01

    Eesti Meremuuseumi rekonstrueeritud vesilennukite angaarid Tallinnas Vesilennuki 6, valminud 2012. Eesti kultuurkapitali aastapreemia 2012. Arhitektid Raivo Kotov, Andrus Kõresaar, Indrek Mikk, Margit Aule, Tõnis Savi, Lea Laidra, Karis Kahr, Jelena Altmäe, Jaanus Männik (KOKO Arhitektid). Sisearhitektid Margit Argus, Andrus Kõresaar, Olga Batuhtina (KOKO Arhitektid). Raudbetoonkonstruktsioonide renoveerimisprojekt Karl Õiger, Heiki Onton (Tallinna Tehnikaülikool). Uued konstruktsioonid Neoprojekt

  9. Vabaduse väljak = The first design stage of Freedom Square / Margit Mutso

    Index Scriptorium Estoniae

    Mutso, Margit, 1966-

    2010-01-01

    Tallinna Vabaduse väljakust, mis pälvis Eesti Kultuurkapitali 2009. aasta aastapreemia uue kvaliteedi eest Eesti linnaehituses ja avaliku ruumi loomisel. Arhitektid: Andres Alver, Veljo Kaasik, Tiit Trummal, kaasautorid Indrek Rünkla, Tarmo Laht, Sven Koppel, Ulla Saar, Toomas Tammis (Alver Arhitektid OÜ). Ajaloolane Rein Zobel. Žürii liikmete Kalle Komissarovi ja Mait Summataveti hinnang väljakule

  10. Kohalik tööstus pelgab pankade ja väliskapitali kokkumängu / Margit Aedla

    Index Scriptorium Estoniae

    Aedla, Margit, 1970-

    2003-01-01

    Tallinna Piimatööstuse juhatuse esimees Aare Annus spekuleerib võimaluse üle, mille kohaselt võidakse Eesti ühinemisel EL-iga hakata rootslaste omanduses olevate pankade kaudu mõjutama meie ettevõtete käekäiku, sest kardetakse sealsete turuliidrite positsioonide halvenemist. Eesti Ühispanga juht Ain Hanschmidt ja Hansapanga juht Indrek Neivelt välistavad sellise võimaluse

  11. Restauratsioon / Mart Velsker

    Index Scriptorium Estoniae

    Velsker, Mart, 1966-

    1998-01-01

    Arvustus: Üheksavägine. Tartu : Erakkond, 1997.Märka, Veiko. Tühja aju korinad; Rahman, Jan. Vasõst vask; Rüütle, Indrek. Lahkumine Puhjast; Serpent, Franȯis. Ka jumal on inimene (kõik EK$i Kaasaegse Kirjanduse Keskuse väljaanded, Tartu, 1997). Vastukaja: Pilv, Aare. Vastuseks Mart Velskri 'Restauratsioonile' // Vikerkaar (1998) nr. 4-5, lk. 185-186

  12. Karakteriga hotell - L'Ermitage : Toompuiestee 19, Tallinn = A Hotel with Character - L'Ermitage : Toompuiestee 19, Tallinn / Regina Viljasaar

    Index Scriptorium Estoniae

    Viljasaar, Regina

    2004-01-01

    Hoone esifassaad on kaetud tumepruuniks patineerunud vasega, hoovipoolne külg on roosa. Uuenduslikud on õhukesed põrandaküttega vahelaed. Projekteerija: Arhitektuuribüroo Pluss. Autor Indrek Allmann. Konstruktor: Inseneribüroo Pike. Sisekujundaja Tatjana Jakobson. I korruse avaliku tsooni kujundas Pille Lausmäe. Projekt 2003, valmis 2004. I ja tüüpkorruse plaan, sisevaade, 5 välisvaadet

  13. Artur Rinne, härra Punttila ja Charley tädi Gert Kiiler

    Index Scriptorium Estoniae

    Kiiler, Gert, 1974-

    2009-01-01

    Ugala teatri hooaja tulevasi etendusi tutvustavad nende lavastajad: Andrus Kivirähk "Vanamehed seitsmendalt" - lavastaja Peeter Tammearu. Mati Põldre, Margus Vaher "Arturi laulud ja aastad" - lavastaja Margus Vaher. Sandor Marai "Küünlad põlevad lõpuni..."- lavastaja Indrek Sammul. Berthold Brecht "Härra Punttila ja tema sulane Matti" - lavastaja Kalju Komissarov. Brandon Thomas "Charley tädi" - lavastaja Taago Tubin

  14. Elamise hele kergus / Ingrid Sembach-Sakias

    Index Scriptorium Estoniae

    Sembach-Sakias, Ingrid

    2004-01-01

    Klaasist eramu Silgu tänaval Tallinnas. Laed ja põrandad, v. a. magamistoad, on betoonist. Arhitektid Ülar Mark ja Indrek Tiigi, AB Urban Mark. Sisekujundaja Raina Lillepõld. Köögi- ja elutoamööbli kavandas perenaine. Elamispind 174, 9 mø. Ill.: korruse plaan, 4 välis- ja 8 sisevaadet, värv. Kommentaar Ülar Margilt

  15. Telekommunikatsiooni & arvutitootjate TOP

    Index Scriptorium Estoniae

    2006-01-01

    Telekommunikatsiooni TOP 30. Tabelid. Vt. samas: Indrek Kald. Elisa ka tänavu esikohal; Väike Tele2 võidab paindlikkusest; Kernel läks üle piiri. Diagrammid. Arvutifirmade TOP 100. Tabelid. Vt. samas: Enn Heinsoo. Esikoha tõi kontori müük; Proeksperdil suund välisturgudele;¡ Ida-Eesti turg arenevale firmale kitsas. Diagrammid. Nimekiri: Omanikud

  16. Orthoptic Treatment of Convergence Insufficiency in Parkinson's Disease: A Case Series.

    Science.gov (United States)

    Kergoat, Hélène; Law, Caroline; Chriqui, Estefania; Kergoat, Marie-Jeanne; Leclerc, Bernard-Simon; Panisset, Michel; Postuma, Ronald; Irving, Elizabeth L

    2017-01-01

    Introduction: This study reports a case series of orthoptic treatment (OT) for convergence insufficiency (CI) in individuals with Parkinson's disease (PD). Method: We are reporting two cases of individuals with PD who completed OT for CI. Both had a confirmed diagnosis of CI, accompanied by CI-type symptomatology. They each underwent an OT program consisting of three office-based visits and 8 weeks of home-based exercises. Treatment outcome was based on the changes measured pre- versus post-OT on the near point of convergence, positive fusional vergences, and symptomatology score. Results: The two participants successfully completed therapy, gained ability to converge, had fewer symptoms, and were satisfied with the OT-induced changes they felt in their day-to-day lives. Conclusion: This case series show that OT for CI in PD is possible. Further research is required as these results demonstrate that OT has the potential to improve symptomatic CI in these patients. In the meantime, the positive results obtained in these two cases should encourage clinicians to consider OT (a therapy with no/minimal risk) for CI in patients with PD whose quality of life is affected by this binocular dysfunction.

  17. Influence of oxytocin on emotion recognition from body language: A randomized placebo-controlled trial.

    Science.gov (United States)

    Bernaerts, Sylvie; Berra, Emmely; Wenderoth, Nicole; Alaerts, Kaat

    2016-10-01

    The neuropeptide 'oxytocin' (OT) is known to play a pivotal role in a variety of complex social behaviors by promoting a prosocial attitude and interpersonal bonding. One mechanism by which OT is hypothesized to promote prosocial behavior is by enhancing the processing of socially relevant information from the environment. With the present study, we explored to what extent OT can alter the 'reading' of emotional body language as presented by impoverished biological motion point light displays (PLDs). To do so, a double-blind between-subjects randomized placebo-controlled trial was conducted, assessing performance on a bodily emotion recognition task in healthy adult males before and after a single-dose of intranasal OT (24 IU). Overall, a single-dose of OT administration had a significant effect of medium size on emotion recognition from body language. OT-induced improvements in emotion recognition were not differentially modulated by the emotional valence of the presented stimuli (positive versus negative) and also, the overall tendency to label an observed emotional state as 'happy' (positive) or 'angry' (negative) was not modified by the administration of OT. Albeit moderate, the present findings of OT-induced improvements in bodily emotion recognition from whole-body PLD provide further support for a link between OT and the processing of socio-communicative cues originating from the body of others. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies.

    Science.gov (United States)

    Walum, Hasse; Waldman, Irwin D; Young, Larry J

    2016-02-01

    Over the last decade, oxytocin (OT) has received focus in numerous studies associating intranasal administration of this peptide with various aspects of human social behavior. These studies in humans are inspired by animal research, especially in rodents, showing that central manipulations of the OT system affect behavioral phenotypes related to social cognition, including parental behavior, social bonding, and individual recognition. Taken together, these studies in humans appear to provide compelling, but sometimes bewildering, evidence for the role of OT in influencing a vast array of complex social cognitive processes in humans. In this article, we investigate to what extent the human intranasal OT literature lends support to the hypothesis that intranasal OT consistently influences a wide spectrum of social behavior in humans. We do this by considering statistical features of studies within this field, including factors like statistical power, prestudy odds, and bias. Our conclusion is that intranasal OT studies are generally underpowered and that there is a high probability that most of the published intranasal OT findings do not represent true effects. Thus, the remarkable reports that intranasal OT influences a large number of human social behaviors should be viewed with healthy skepticism, and we make recommendations to improve the reliability of human OT studies in the future. Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  19. A common oxytocin receptor gene (OXTR) polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans.

    Science.gov (United States)

    Feng, C; Lori, A; Waldman, I D; Binder, E B; Haroon, E; Rilling, J K

    2015-09-01

    Intranasal oxytocin (OT) can modulate social-emotional functioning and related brain activity in humans. Consequently, OT has been discussed as a potential treatment for psychiatric disorders involving social behavioral deficits. However, OT effects are often heterogeneous across individuals. Here we explore individual differences in OT effects on the neural response to social cooperation as a function of the rs53576 polymorphism of the oxytocin receptor gene (OXTR). Previously, we conducted a double-blind, placebo-controlled study in which healthy men and women were randomized to treatment with intranasal OT or placebo. Afterwards, they were imaged with functional magnetic resonance imaging while playing an iterated Prisoner's Dilemma Game with same-sex partners. Within the left ventral caudate nucleus, intranasal OT treatment increased activation to reciprocated cooperation in men, but tended to decrease activation in women. Here, we show that these sex differences in OT effects are specific to individuals with the rs53576 GG genotype, and are not found for other genotypes (rs53576 AA/AG). Thus, OT may increase the reward or salience of positive social interactions for male GG homozygotes, while decreasing those processes for female GG homozygotes. These results suggest that rs53576 genotype is an important variable to consider in future investigations of the clinical efficacy of intranasal OT treatment. © 2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

  20. Occupational therapy practice in emergency care: Occupational therapists' perspectives.

    Science.gov (United States)

    Spang, Lisa; Holmqvist, Kajsa

    2015-01-01

    Emergency care takes place in a complex work environment that is characterized by critically ill patients, short hospital stays, and a wide variety of different healthcare professionals. Studies of occupational therapists' (OTs) experiences of working within emergency care have shown that they often experience difficulties in explaining the essence of occupational therapy and have to justify their approaches. Much effort has been made in Sweden to help OTs dispel the notion that occupational therapy is difficult to explain, and the aim of this study was to describe how Swedish OTs perceive their work in emergency care. A qualitative descriptive approach was taken, and 14 interviews were conducted with OTs working in emergency care. Qualitative content analysis was used to analyse the data. The overall theme that emerged was "Feeling established through deliberate occupation-based work". The underlying categories showed different strategies used by the OTs to provide occupational therapy in an emergency care context. Deliberate strategies were used to demonstrate the effectiveness of occupational therapy and its approaches to patients and other health care professionals, and this resulted in the OTs feeling both established and needed. Unlike the OTs in previous studies, the Swedish OTs experienced no difficulties in explaining occupational therapy and could make convincing arguments for their interventions. Parallel to their clinical work, the OTs worked with on-going development to find ways to improve their approaches. In summary, these Swedish OTs seem to have been provided with a professional language and the knowledge required to establish themselves in an emergency care setting.

  1. Sex differences in neural activation following different routes of oxytocin administration in awake adult rats.

    Science.gov (United States)

    Dumais, Kelly M; Kulkarni, Praveen P; Ferris, Craig F; Veenema, Alexa H

    2017-07-01

    The neuropeptide oxytocin (OT) regulates social behavior in sex-specific ways across species. OT has promising effects on alleviating social deficits in sex-biased neuropsychiatric disorders. However little is known about potential sexually dimorphic effects of OT on brain function. Using the rat as a model organism, we determined whether OT administered centrally or peripherally induces sex differences in brain activation. Functional magnetic resonance imaging was used to examine blood oxygen level-dependent (BOLD) signal intensity changes in the brains of awake rats during the 20min following intracerebroventricular (ICV; 1μg/5μl) or intraperitoneal (IP; 0.1mg/kg) OT administration as compared to baseline. ICV OT induced sex differences in BOLD activation in 26 out of 172 brain regions analyzed, with 20 regions showing a greater volume of activation in males (most notably the nucleus accumbens and insular cortex), and 6 regions showing a greater volume of activation in females (including the lateral and central amygdala). IP OT also elicited sex differences in BOLD activation with a greater volume of activation in males, but this activation was found in different and fewer (10) brain regions compared to ICV OT. In conclusion, exogenous OT modulates neural activation differently in male versus female rats with the pattern and magnitude, but not the direction, of sex differences depending on the route of administration. These findings highlight the need to include both sexes in basic and clinical studies to fully understand the role of OT on brain function. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. A pilot study of rhythm and timing training as a supplement to occupational therapy in stroke rehabilitation.

    Science.gov (United States)

    Hill, Valerie; Dunn, Leah; Dunning, Kari; Page, Stephen J

    2011-01-01

    Stroke is the leading cause of disability. A need exists for an effective intervention to enhance upper extremity (UE) motor abilities and activities of daily living (ADL) performance. The objectives of this pilot study were to (1) determine the feasibility of adding Interactive Metronome (IM) to an occupational therapy (OT) program; and (2) determine changes in UE impairments, function, quality of life, and perceived physical performance ability and satisfaction using a combined IM + OT regimen compared with OT alone for adults with chronic stroke. This pilot study (n=10) used a 2-group (OT or IM+OT) pretest-posttest design. The intervention involved 60 minutes of IM + OT or OT alone, 3 days a week for 10 weeks. Outcome measures included the UE Fugl-Meyer (impairment), the Arm Motor Ability Test (function), the Box and Block Test (function), Stroke Impact Scale (quality of life), and the Canadian Occupational Performance Measure (perceived performance ability and satisfaction). It was feasible to add IM to OT. The IM+OT group demonstrated decreased impairment and increased quality of life. However, the OT-alone group demonstrated greater gains in function, perceived physical performance ability, and satisfaction. These findings suggest that rhythm and timing training using the IM is a feasible intervention to consider as part of therapy treatment. However, IM may fit best for prefunctional treatment, as it seemed to primarily decrease impairment. It may also serve as a supplement before or after treatment in order to maximize rehabilitation potential. Clinical implications and suggestions for future studies are provided.

  3. 75 FR 42833 - Prohibited Service at Savings and Loan Holding Companies

    Science.gov (United States)

    2010-07-22

    ....treas.gov . OTS will post comments and the related index on the OTS Internet Site at http://www.ots... regulations applicable to savings associations under Regulation DD. Regulation DD implements the Truth in...

  4. Orthostatic Tremor and Orthostatic Myoclonus: Weight-bearing Hyperkinetic Disorders: A Systematic Review, New Insights, and Unresolved Questions

    Directory of Open Access Journals (Sweden)

    Anhar Hassan

    2016-11-01

    Full Text Available Background: Orthostatic tremor (OT and orthostatic myoclonus (OM are weight-bearing hyperkinetic movement disorders most commonly affecting older people that induce “shaky legs” upon standing. OT is divided into “classical” and “slow” forms based on tremor frequency. In this paper, the first joint review of OT and OM, we review the literature and compare and contrast their demographic, clinical, electrophysiological, neuroimaging, pathophysiological, and treatment characteristics. Methods: A PubMed search up to July 2016 using the phrases “orthostatic tremor,” “orthostatic myoclonus,” “shaky legs,” and “shaky legs syndrome” was performed. Results: OT and OM should be suspected in older patients reporting unsteadiness with prolonged standing and/or who exhibit cautious, wide-based gaits. Surface electromyography (SEMG is necessary to verify the diagnoses. Functional neuroimaging and electrophysiology suggest the generator of classical OT lies within the cerebellothalamocortical network. For OM, and possibly slow OT, the frontal, subcortical cerebrum is the most likely origin. Clonazepam is the most useful medication for classical OT, and levetiracetam for OM, although results are often disappointing. Deep brain stimulation appears promising for classical OT. Rolling walkers reliably improve gait affected by these disorders, as both OT and OM attenuate when weight is transferred from the legs to the arms. Discussion: Orthostatic hyperkinesias are likely underdiagnosed, as SEMG is often unavailable in clinical practice, and thus may be more frequent than currently recognized. The shared weight-bearing induction of OT and OM may indicate a common pathophysiology. Further research, including use of animal models, is necessary to better define the prevalence and pathophysiology of OT and OM, in order to improve their treatment, and provide additional insights into basic balance and gait mechanisms.

  5. Cuban Ocular Toxoplasmosis Epidemiology Study (COTES): incidence and prevalence of ocular toxoplasmosis in Central Cuba.

    Science.gov (United States)

    Bustillo, Jorge L; Diaz, Jose D; Pacheco, Idarmes C; Gritz, David C

    2015-03-01

    Serological studies indicate that rates of ocular toxoplasmosis (OT) vary geographically, with higher rates in tropical regions. Little is known about population-based rates of active OT. We aimed to describe the epidemiology of OT in Central Cuba. This large-population, cross-sectional cohort study used a prospective database at a large regional referral centre in Central Cuba. The patient database was searched for all patients who presented with OT during the 12-month study period from 1 April 2011 to 31 March 2012. Inclusion criteria were the clinical diagnosis of OT, characterised by focal retinochoroidal inflammation and a response to therapy as expected. Gender-stratified and age-stratified study population data from the 2012 Cuban Census were used to calculate incidence rates and prevalence ratios. Among 279 identified patients with OT, 158 presented with active OT. Of these, 122 new-onset and 36 prior-onset cases were confirmed. Based on the total population in the Sancti Spiritus province (466,106 persons), the overall incidence of active OT was 26.2 per 100,000 person-years (95% CI 21.7 to 31.3) with an annual prevalence ratio of 33.9 per 100,000 persons (95% CI 28.8 to 39.6). The incidence of active OT was lowest in the oldest age group and highest in patients aged 25-44 years (4.5 and 42.1 per 100,000 person-years, respectively). This first report describing population-based rates of OT in the Cuban population highlights the importance of patient age as a likely risk factor for OT. Disease rates were found to be highest in females and young to middle-aged adults. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  6. Oxytocin induces prostaglandin F2 alpha release in pregnant cows: influence of gestational age and oxytocin receptor concentrations.

    Science.gov (United States)

    Fuchs, A R; Rollyson, M K; Meyer, M; Fields, M J; Minix, J M; Randel, R D

    1996-03-01

    Brahman cows with known breeding dates received i.v. injections of either 10 or 100 IU oxytocin (OT) on Days 50, 150, 250, or 280 of gestation (n = 6 for each stage). Concentrations of the prostaglandin (PG) F2 alpha metabolite, 13,14-dihydro-15-keto-prostaglandin (PGFM), and OT were measured in samples of peripheral plasma collected at 15-min intervals for 1 h before and 1 h after treatment and then at 30-min intervals for 3 h. Plasma progesterone was measured daily for 14 days after OT injections on Days 50 and 250 of gestation. The increase in plasma OT after injection was dose-dependent (p = 0.001) but not affected by stage of gestation. Plasma PGFM increased after OT in a dose- and stage-dependent manner (p = 0.0001). At Day 280, the increase in plasma PGFM after 100 IU OT was sevenfold greater than at Day 50. Plasma progesterone declined significantly during the 7th to 12th days postinjection and returned to normal pregnancy values by the 14th day (4.4 +/- 0.3 ng/ml) except in two cows treated on Day 50 of gestation that later aborted. In these, plasma progesterone was significantly lower, 2.6 +/- 0.1 ng/ml. In a second experiment, the concentration of OT receptors was determined in endometrium collected from purebred Angus or Hereford cows slaughtered on Days 50, 150, 250, and 280 of gestation (n = 3 or 4 at each stage). Endometrial concentrations of OT receptor changed as a function of gestational age, increasing sixfold from Day 50 to Day 280, which was parallel to the increase by OT of plasma PGFM. Thus, endometrial OT receptors are functionally coupled to PGF2 alpha release during pregnancy, and their concentration determines the magnitude of OT-induced PGF2 alpha release during gestation. Consequently, endogenous OT is a factor in the regulation of PGF2 alpha release from the bovine uterus during pregnancy and parturition.

  7. The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder.

    Science.gov (United States)

    Greene, R K; Spanos, M; Alderman, C; Walsh, E; Bizzell, J; Mosner, M G; Kinard, J L; Stuber, G D; Chandrasekhar, T; Politte, L C; Sikich, L; Dichter, G S

    2018-03-27

    Intranasal oxytocin (OT) has been shown to improve social communication functioning of individuals with autism spectrum disorder (ASD) and, thus, has received considerable interest as a potential ASD therapeutic agent. Although preclinical research indicates that OT modulates the functional output of the mesocorticolimbic dopamine system that processes rewards, no clinical brain imaging study to date has examined the effects of OT on this system using a reward processing paradigm. To address this, we used an incentive delay task to examine the effects of a single dose of intranasal OT, versus placebo (PLC), on neural responses to social and nonsocial rewards in children with ASD. In this placebo-controlled double-blind study, 28 children and adolescents with ASD (age: M = 13.43 years, SD = 2.36) completed two fMRI scans, one after intranasal OT administration and one after PLC administration. During both scanning sessions, participants completed social and nonsocial incentive delay tasks. Task-based neural activation and connectivity were examined to assess the impact of OT relative to PLC on mesocorticolimbic brain responses to social and nonsocial reward anticipation and outcomes. Central analyses compared the OT and PLC conditions. During nonsocial reward anticipation, there was greater activation in the right nucleus accumbens (NAcc), left anterior cingulate cortex (ACC), bilateral orbital frontal cortex (OFC), left superior frontal cortex, and right frontal pole (FP) during the OT condition relative to PLC. Alternatively, during social reward anticipation and outcomes, there were no significant increases in brain activation during the OT condition relative to PLC. A Treatment Group × Reward Condition interaction revealed relatively greater activation in the right NAcc, right caudate nucleus, left ACC, and right OFC during nonsocial relative to social reward anticipation during the OT condition relative to PLC. Additionally, these analyses revealed

  8. Radioimmunoassay of urine oxytocin in man

    International Nuclear Information System (INIS)

    Zebidi, A.; Geelen, G.; Allevard, A.M.; Sempore, B.; Jarsaillon, E.; Meunier, C.; Gharib, C.

    1978-01-01

    A radioimmunoassay (RIA) for oxytocin (OT) in urine is described. 125 I-OT was prepared, and antibodies were raised in rabbits against OT coupled to bovine serumalbumine. This allowed us to set up a RIA for OT which limit of detection is 1.25 pg/tube (0.6 μU). The use of an extraction procedure using CG 50 Amberlite is essential. The recovery after extraction reaches 70.5 %. pH 5 is the optimum pH were urine samples must be stored. The superposition of the elution peak of endogenous OT on that of exogenous hormone is an argument in favour of the validity of such an extraction procedure. Daily urinary excretion of OT reaches 9.58 mU +- 3.48 in 18 healthy young men [fr

  9. Difficulties in organ procurement and transplantation in the aboriginal minority people in Taiwan.

    Science.gov (United States)

    Shih, F J; Chang, Y C; Chen, C F; Lin, F J; Huang, Y S; Yan, Y H; Shih, F Jong; Chen, C R

    2012-05-01

    Aboriginal people (AP) are a minority group in Taiwan. Little information on their perspectives on organ transplantation (OT) is available. Their rights for organ donation (OD) and as OT recipients (OTR) are constrained as a vulnerable population in society. This research sought to explore various Highland Aborigine Tribes beliefs systems and concepts related to OT. We employed a qualitative design on a purposive sample including seven categories of Taiwanese AP. Data collected by face-to-face interviews were evaluated by content analysis. Seventy-five informants (45 female and 30 males) of 18 to 82 years from seven tribes completed interviews: Bunun (n = 20), Shao (n = 18), Tsou (n = 15), Amis (n = 12), Truku (n = 4), Rukai (n = 3), and Puyuma (n = 3). Of there, 33% had no idea of OT. All informants reported lack of knowledge of OD, organ procurement, and OTR. Eighty percent (45-82 years) had no willingness for OD or OTR; others might consult family members and health professionals (HP) to learn about OT. Seven hindering factors were identified: (1) having no background of OT; (2) limited impressions obtained from television news reports; (3) negative concepts of donating one's organs to others; (4) OT concepts contrast with cultural meanings of death; (5) possibility of being stigmatized; (6) fear of being rejected by others; and (7) HP had never mentioned OT. Taiwan APs' perspectives of OT concepts showed the majority to be unfamiliar with the concept and benefits of OT. Future research is necessary to explore the possible avenues to facilitate communications between HP and AP leaders, as well as elders in each AP category in Taiwan. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. A conceptual-practice model for occupational therapy to facilitate return to work in breast cancer patients.

    Science.gov (United States)

    Désiron, Huguette A M; Donceel, Peter; de Rijk, Angelique; Van Hoof, Elke

    2013-12-01

    Improved therapies and early detection have significantly increased the number of breast cancers survivors, leading to increasing needs regarding return to work (RTW). Occupational therapy (OT) interventions provide successful RTW assistance for other conditions, but are not validated in breast cancer. This paper aims to identify a theoretical framework for OT intervention by questioning how OT models can be used in OT interventions in RTW of breast cancer patients; criteria to be used to select these models and adaptations that would be necessary to match the OT model(s) to breast cancer patients' needs? Using research specific criteria derived from OT literature (conceptual OT-model, multidisciplinary, referring to the International Classification of functioning (ICF), RTW in breast cancer) a search in 9 electronic databases was conducted to select articles that describe conceptual OT models. A content analysis of those models complying to at least two of the selection criteria was realised. Checking for breast cancer specific issues, results were matched with literature of care-models regarding RTW in breast cancer. From the nine models initially identified, three [Canadian Model of Occupational Performance, Model of Human Occupation (MOHO), Person-Environment-Occupation-Performance model] were selected based on the selection criteria. The MOHO had the highest compliance rate with the criteria. To enhance usability in breast cancer, some adaptations are needed. No OT model to facilitate RTW in breast cancer could be identified, indicating a need to fill this gap. Individual and societal needs of breast cancer patients can be answered by using a MOHO-based OT model, extended with indications for better treatment, work-outcomes and longitudinal process factors.

  11. Subcaste differences in neural activation suggest a prosocial role for oxytocin in eusocial naked mole-rats.

    Science.gov (United States)

    Hathaway, Georgia A; Faykoo-Martinez, Mariela; Peragine, Deane E; Mooney, Skyler J; Holmes, Melissa M

    2016-03-01

    The neuropeptide oxytocin (OT) influences prosocial behavior(s), aggression, and stress responsiveness, and these diverse effects are regulated in a species- and context-specific manner. The naked mole-rat (Heterocephalus glaber) is a unique species with which to study context-dependent effects of OT, exhibiting a strict social hierarchy with behavioral specialization within the subordinate caste: soldiers are aggressive and defend colonies against unfamiliar conspecifics while workers are prosocial and contribute to in-colony behaviors such as pup care. To determine if OT is involved in subcaste-specific behaviors, we compared behavioral responses between workers and soldiers of both sexes during a modified resident/intruder paradigm, and quantified activation of OT neurons in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON) using the immediate-early-gene marker c-fos co-localized with OT neurons. Resident workers and soldiers were age-matched with unfamiliar worker stimulus animals as intruders, and encounters were videorecorded and scored for aggressive behaviors. Colony-matched controls were left in their home colony for the duration of the encounters. Brains were extracted and cell counts were conducted for OT immunoreactive (ir), c-fos-ir, and percentage of OT-c-fos double-labeled cells. Results indicate that resident workers were less aggressive but showed greater OT neural activity than soldiers. Furthermore, a linear model including social treatment, cortisol, and subcaste revealed that subcaste was the only significant predictor of OT-c-fos double-labeled cells in the PVN. These data suggest that in naked mole-rats OT promotes prosocial behaviors rather than aggression and that even within subordinates status exerts robust effects on brain and behavior. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. The effects of oxytocin on fear recognition in patients with schizophrenia and in healthy controls

    Directory of Open Access Journals (Sweden)

    Meytal eFischer-Shofty

    2013-07-01

    Full Text Available Individuals who suffer from schizophrenia often show a marked deficit in recognition of emotional facial expressions, as part of broader impairment of social cognition. Research has shown that recognition of negative emotions, specifically fear recognition, is particularly impaired among patients with schizophrenia. Recently we reported that intranasal administration of OT (IN OT increased the ability to correctly recognize fear in a group of healthy men. The aim of the current study was to examine the effects of IN OT administration on fear recognition among patients with schizophrenia. Based on previous research, we also sought to examine a possible selective effect of OT dependent on baseline performance, hypothesizing that IN OT would have a greater enhancement effect on less proficient individuals. It was thus hypothesized that patients will show more improvement in fear recognition following the administration of IN OT as compared to controls. Sixty six participants (31 schizophrenia patients, 35 healthy controls were enrolled in the current study. All participants received treatment of a single dose of 24 IU IN OT and an equivalent amount of placebo, one week apart. The participants’ ability to accurately recognize fear and happiness was evaluated using a face morphing task. Overall, as a group, both patients and healthy control participants were more accurate in recognizing fearful facial expressions, but not happy faces, following IN OT administration, as compared to their performance following placebo. IN OT did not differentially affect emotion recognition in patients and healthy controls. Yet, the results indicated a selective effect for IN OT, in which the hormone improves fear recognition only among individuals whose baseline performance was below the median, regardless of their psychiatric status.

  13. Involvement of the oxytocin system in the bed nucleus of the stria terminalis in the sex-specific regulation of social recognition

    Science.gov (United States)

    Dumais, Kelly M.; Alonso, Andrea G.; Immormino, Marisa A.; Bredewold, Remco; Veenema, Alexa H.

    2015-01-01

    Sex differences in the oxytocin (OT) system in the brain may explain why OT often regulates social behaviors in sex-specific ways. However, a link between sex differences in the OT system and sex-specific regulation of social behavior has not been tested. Here, we determined whether sex differences in the OT receptor (OTR) or in OT release in the posterior bed nucleus of the stria terminalis (pBNST) mediates sex-specific regulation of social recognition in rats. We recently showed that, compared to female rats, male rats have a three-fold higher OTR binding density in the pBNST, a sexually dimorphic area implicated in the regulation of social behaviors. We now demonstrate that OTR antagonist (5 ng/0.5 μl/side) administration into the pBNST impairs social recognition in both sexes, while OT (100 pg/0.5 μl/side) administration into the pBNST prolongs the duration of social recognition in males only. These effects seem specific to social recognition, as neither treatment altered total social investigation time in either sex. Moreover, baseline OT release in the pBNST, as measured with in vivo microdialysis, did not differ between the sexes. However, males showed higher OT release in the pBNST during social recognition compared to females. These findings suggest a sex-specific role of the OT system in the pBNST in the regulation of social recognition. PMID:26630388

  14. Oxytocin and prolactin release after hypertonic saline administration in melatonin-treated male Syrian hamsters

    International Nuclear Information System (INIS)

    Juszczak, M.; Steger, R.W.; Fadden, C.; Bartke, A.

    1996-01-01

    The aim of the present investigations was to examine the effects of melatonin (Mel) on oxytocin (OT) release under conditions of osmotic stimulation, brought about by hypertonic saline administration, as well as to determine whether osmotically stimulated OT release in Mel-treated Syrian hamster is associated with alterations in the release of prolactin (PRL) and in norepinephrine (NE) and dopamine (DA) content in the hypothalamus. In both Mel- and vehicle-treated hamsters, injection of hypertonic saline was followed by a significant decrease in OT content in the pituitary neurointermediate lobe (NIL) and elevation of plasma OT and PRL levels. Melatonin injections had no significant affect on NIL OT content in either isotonic- or hypertonic-saline treated animals. Pretreatment with Mel did not alter plasma OT or PRL levels in isotonic saline-injected animals. However, Mel facilitated the release of OT, but prevented the release of PRL after hypertonic saline administration. Melatonin treatment reduced hypothalamic NE content (but not that of DA) in isotonic-saline treated animals. After osmotic stimulation, hypothalamic content of NE and DA was significantly lower in Mel-treated than in vehicle-treated animals. Data from the present study suggest that the osmotically-stimulated release of OT and PRL seems to be related to the activation of noradrenergic rather than dopaminergic transmission. Both dopaminergic and noradrenergic transmission may be, however, involved in mediating the effects of Mel on the osmotically-activated OT and PRL release. (author). 48 refs, 3 figs

  15. Oxytocin and prolactin release after hypertonic saline administration in melatonin-treated male Syrian hamsters

    Energy Technology Data Exchange (ETDEWEB)

    Juszczak, M.; Steger, R.W.; Fadden, C.; Bartke, A. [Southern Illinois Univ., Carbondale, IL (United States)

    1996-12-31

    The aim of the present investigations was to examine the effects of melatonin (Mel) on oxytocin (OT) release under conditions of osmotic stimulation, brought about by hypertonic saline administration, as well as to determine whether osmotically stimulated OT release in Mel-treated Syrian hamster is associated with alterations in the release of prolactin (PRL) and in norepinephrine (NE) and dopamine (DA) content in the hypothalamus. In both Mel- and vehicle-treated hamsters, injection of hypertonic saline was followed by a significant decrease in OT content in the pituitary neurointermediate lobe (NIL) and elevation of plasma OT and PRL levels. Melatonin injections had no significant affect on NIL OT content in either isotonic- or hypertonic-saline treated animals. Pretreatment with Mel did not alter plasma OT or PRL levels in isotonic saline-injected animals. However, Mel facilitated the release of OT, but prevented the release of PRL after hypertonic saline administration. Melatonin treatment reduced hypothalamic NE content (but not that of DA) in isotonic-saline treated animals. After osmotic stimulation, hypothalamic content of NE and DA was significantly lower in Mel-treated than in vehicle-treated animals. Data from the present study suggest that the osmotically-stimulated release of OT and PRL seems to be related to the activation of noradrenergic rather than dopaminergic transmission. Both dopaminergic and noradrenergic transmission may be, however, involved in mediating the effects of Mel on the osmotically-activated OT and PRL release. (author). 48 refs, 3 figs.

  16. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole.

    Science.gov (United States)

    Modi, Meera E; Inoue, Kiyoshi; Barrett, Catherine E; Kittelberger, Kara A; Smith, Daniel G; Landgraf, Rainer; Young, Larry J

    2015-07-01

    The central melanocortin (MC) system has been widely studied for its effects on food intake and sexual behavior. However, the MC system, and more specifically the MC4 receptor (MC4R), also interacts with neurochemical systems that regulate socioemotional behaviors, including oxytocin (OT) and dopamine. In monogamous prairie voles, OT and dopamine interact to promote partner preference formation, a laboratory measure of an enduring social bond between mates. Here we investigated the effects of MC receptor activation on partner preference formation in prairie voles, as well as the interaction between the MC and OT systems during this process. Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II (MTII), and the highly selective, small-molecule MC4R agonist, Pf-446687, enhanced partner preference formation in the prairie vole, but not in the non-monogamous meadow vole. MTII-induced partner preferences were enduring, as they were present 1 week after drug manipulation. The prosocial effects of MCR agonists may be mediated, in part, through modulation of OT, as coadministration of an OT receptor antagonist prevented MTII-induced partner preferences. MTII also selectively activated hypothalamic OT neurons and potentiated central OT release. As OT has been shown to enhance some aspects of social cognition in humans, our data suggest that the MC4R may be a viable therapeutic target for enhancing social function in psychiatric disorders, including autism spectrum disorders and schizophrenia, potentially through activation of the OT system.

  17. Involvement of the oxytocin system in the bed nucleus of the stria terminalis in the sex-specific regulation of social recognition.

    Science.gov (United States)

    Dumais, Kelly M; Alonso, Andrea G; Immormino, Marisa A; Bredewold, Remco; Veenema, Alexa H

    2016-02-01

    Sex differences in the oxytocin (OT) system in the brain may explain why OT often regulates social behaviors in sex-specific ways. However, a link between sex differences in the OT system and sex-specific regulation of social behavior has not been tested. Here, we determined whether sex differences in the OT receptor (OTR) or in OT release in the posterior bed nucleus of the stria terminalis (pBNST) mediates sex-specific regulation of social recognition in rats. We recently showed that, compared to female rats, male rats have a three-fold higher OTR binding density in the pBNST, a sexually dimorphic area implicated in the regulation of social behaviors. We now demonstrate that OTR antagonist (5 ng/0.5 μl/side) administration into the pBNST impairs social recognition in both sexes, while OT (100 pg/0.5 μl/side) administration into the pBNST prolongs the duration of social recognition in males only. These effects seem specific to social recognition, as neither treatment altered total social investigation time in either sex. Moreover, baseline OT release in the pBNST, as measured with in vivo microdialysis, did not differ between the sexes. However, males showed higher OT release in the pBNST during social recognition compared to females. These findings suggest a sex-specific role of the OT system in the pBNST in the regulation of social recognition. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Occupational Therapy ’s Role in an Interprofessional Student-Run Free Clinic: Challenges and Opportunities Identified

    Directory of Open Access Journals (Sweden)

    Oaklee Rogers

    2017-07-01

    Full Text Available Student-run free clinics (SRFCs provide services to underserved populations while enhancing student education. Occupational therapy (OT participation in integrated care SRFCs is an emerging area of practice and enhances the interprofessional model necessary for holistic patient care. The Student Health Outreach for Wellness (SHOW organization, located in Phoenix, Arizona, is a SRFC comprised of three state universities that incorporates nine different health professional programs to deliver interprofessional care, including OT. The SHOW clinic provides direct care services where student volunteers practice clinical and interprofessional skills under the guidance of licensed health care providers. OT preceptors and students participate in team-based assessment and care delivery to practice their discipline-specific treatment knowledge of upper-extremity impairments, musculoskeletal pain, medication management, fall prevention, and behavioral health issues, among many others. OT integration into the clinic provides students and preceptors an opportunity to build a unique skill set in interprofessional care, educate other disciplines about OT, and become emerging leaders in the field. Challenges for OT involvement in this SRFC include recruitment and sustainability of volunteers and lack of knowledge and understanding about the role of OT on an interprofessional team. Further research is needed to identify additional benefits of OT services in SFRCs.

  19. MATERNAL MENTAL HEALTH MODERATES THE RELATIONSHIP BETWEEN OXYTOCIN AND INTERACTIVE BEHAVIOR.

    Science.gov (United States)

    Samuel, Simcha; Hayton, Barbara; Gold, Ian; Feeley, Nancy; Carter, C Sue; Zelkowitz, Phyllis

    2015-01-01

    Mothers with mood or anxiety disorders exhibit less optimal interactive behavior. The neuropeptide oxytocin (OT) has been linked to more optimal interactive behaviors in mothers without mental illness, and it may play a particularly beneficial role in mothers with mood or anxiety disorders given its antidepressant and anxiolytic functions. We compared the relationship between OT and interactive behavior in mothers with and without mental health problems. Participants included 20 women diagnosed with postpartum mood or anxiety disorders (clinical sample) and 90 women with low levels of depression and anxiety during pregnancy and postpartum (community sample). At 2 months' postpartum, blood was drawn to assess maternal OT levels, and mother-infant interaction was coded for maternal sensitivity, intrusiveness, remoteness, and depressiveness. Clinical mothers exhibited less sensitive, more intrusive, and more depressive interactive behaviors than did community mothers. The groups did not differ in OT levels. Mothers with higher OT levels were less intrusive with their infants. Higher OT levels were associated with less depressive interactive behavior only in clinical mothers. OT was associated with positive interactive behaviors in both groups. In clinical mothers, the calming and soothing effects of OT may promote more relaxed, energetic, and infant-focused interactive behaviors. © 2015 Michigan Association for Infant Mental Health.

  20. Patient compliance with a health care provider referral for an occupational therapy lymphedema consult.

    Science.gov (United States)

    Dominick, Sally A; Natarajan, Loki; Pierce, John P; Madanat, Hala; Madlensky, Lisa

    2014-07-01

    Limited information exists on breast cancer patients' compliance to attend outpatient appointments with an occupational therapy (OT) lymphedema specialist. The objectives of this study were (1) to examine patient compliance with a health care provider referral for an OT lymphedema consult and (2) to identify potential barriers to compliance. A retrospective chart review of female breast cancer patients at the UC San Diego Health System was conducted. Electronic medical records were queried for breast cancer patients, who received a health care provider referral for an OT lymphedema consult between June 1, 2010 and December 31, 2011. Descriptive statistics and Fisher's exact chi-square tests were used to examine how specific participant characteristics were associated with attending an OT appointment. A total of 210 female patients received an OT referral from a health care provider related to their breast cancer diagnosis. Forty-three (20.5%) patients did not attend an OT appointment. Non-attenders were more likely to have had fewer lymph nodes removed (Pcancer patients attended recommended OT lymphedema consults, a substantial number of women might benefit from further education about OT for lymphedema prevention following breast cancer treatment. Further research to understand barriers to attendance is recommended, particularly among women with only sentinel nodes removed.