WorldWideScience

Sample records for hp computers

  1. A CAMAC seven-crate system on-line with an HP2116B computer

    International Nuclear Information System (INIS)

    Chernenko, S.P.; Chernykh, E.V.; Filatova, N.A.; Ivanov, A.B.; Kolpakov, I.F.; Nikityuk, N.N.; Smirnov, V.A.; Zanevsky, Yu.V.

    1975-01-01

    A branch of seven CAMAC on-line with an HP2116B computer is described. This system is used for data acquisition from a Cherenkov 90-channel spectrometer, 32 magnetostrictive chambers, 20 registers of the proportional chambers, scalers, and hodoscope registers

  2. HP 9816

    CERN Multimedia

    1982-01-01

    The 9816 was introduced in late 1982. This was the low-cost model in the 200 Series range. It only had two expansion slots and featured a monitor integrated with the system unit and modular keyboard and mass storage (usually a 9121 dual 3.5 inch floppy drive). The monitor was nine inches diagonally with a 400 by 300 dot resolution. The HP 9816 was also designated as the HP 9000 216. It did not include any disk drives but it had a built-in 9 inch monochrome monitor, built-in HP-IB and RS-232 ports and 2 expansion slots. The standard keyboard for the 9816 is a itty-bitty number. The 9816 A came with 128K bytes of memory. The 9816 S included all of the above plus disk based BASIC and a card containing an additional 256K of memory bringing the total memory to 512K but only leaving only one expansion slot open.

  3. HPC Institutional Computing Project: W15_lesreactiveflow KIVA-hpFE Development: A Robust and Accurate Engine Modeling Software

    Energy Technology Data Exchange (ETDEWEB)

    Carrington, David Bradley [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Waters, Jiajia [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-05

    KIVA-hpFE is a high performance computer software for solving the physics of multi-species and multiphase turbulent reactive flow in complex geometries having immersed moving parts. The code is written in Fortran 90/95 and can be used on any computer platform with any popular complier. The code is in two versions, a serial version and a parallel version utilizing MPICH2 type Message Passing Interface (MPI or Intel MPI) for solving distributed domains. The parallel version is at least 30x faster than the serial version and much faster than our previous generation of parallel engine modeling software, by many factors. The 5th generation algorithm construction is a Galerkin type Finite Element Method (FEM) solving conservative momentum, species, and energy transport equations along with two-equation turbulent model k-ω Reynolds Averaged Navier-Stokes (RANS) model and a Vreman type dynamic Large Eddy Simulation (LES) method. The LES method is capable modeling transitional flow from laminar to fully turbulent; therefore, this LES method does not require special hybrid or blending to walls. The FEM projection method also uses a Petrov-Galerkin (P-G) stabilization along with pressure stabilization. We employ hierarchical basis sets, constructed on the fly with enrichment in areas associated with relatively larger error as determined by error estimation methods. In addition, when not using the hp-adaptive module, the code employs Lagrangian basis or shape functions. The shape functions are constructed for hexahedral, prismatic and tetrahedral elements. The software is designed to solve many types of reactive flow problems, from burners to internal combustion engines and turbines. In addition, the formulation allows for direct integration of solid bodies (conjugate heat transfer), as in heat transfer through housings, parts, cylinders. It can also easily be extended to stress modeling of solids, used in fluid structure interactions problems, solidification, porous media

  4. PCM- data processing - description of the program TAPEDUMP for the computer HP-2100 S

    International Nuclear Information System (INIS)

    Ziegler, G.

    1978-01-01

    The assembler program TADEDUMP has the task, to preprocess PCM-data for further processing with a large computer and to put them in an output routine on magnetic tape with a measurement specific header. In the preprocessing the data can be reduced by selection and averaging. In the case of certain reading errors the data are discarded, but the synchronization is reestablished. (orig.) [de

  5. Computational Modeling of Proteins based on Cellular Automata: A Method of HP Folding Approximation.

    Science.gov (United States)

    Madain, Alia; Abu Dalhoum, Abdel Latif; Sleit, Azzam

    2018-06-01

    The design of a protein folding approximation algorithm is not straightforward even when a simplified model is used. The folding problem is a combinatorial problem, where approximation and heuristic algorithms are usually used to find near optimal folds of proteins primary structures. Approximation algorithms provide guarantees on the distance to the optimal solution. The folding approximation approach proposed here depends on two-dimensional cellular automata to fold proteins presented in a well-studied simplified model called the hydrophobic-hydrophilic model. Cellular automata are discrete computational models that rely on local rules to produce some overall global behavior. One-third and one-fourth approximation algorithms choose a subset of the hydrophobic amino acids to form H-H contacts. Those algorithms start with finding a point to fold the protein sequence into two sides where one side ignores H's at even positions and the other side ignores H's at odd positions. In addition, blocks or groups of amino acids fold the same way according to a predefined normal form. We intend to improve approximation algorithms by considering all hydrophobic amino acids and folding based on the local neighborhood instead of using normal forms. The CA does not assume a fixed folding point. The proposed approach guarantees one half approximation minus the H-H endpoints. This lower bound guaranteed applies to short sequences only. This is proved as the core and the folds of the protein will have two identical sides for all short sequences.

  6. SEDRX: A computer program for the simulation Si(Li) and Ge(Hp) x-ray detectors efficiency

    International Nuclear Information System (INIS)

    Benamar, M.A.; Benouali, A.; Tchantchane, A.; Azbouche, A.; Tobbeche, S. Centre de Developpement des Techniques Nucleaires, Algiers; Labo. des Techniques Nucleaires)

    1992-12-01

    The difficulties encountered in measuring the x-ray detectors efficiency has motivated to develop a computer program to simulate this parameter. this program computes the efficiency of detectors as a function of energy. the computation of this parameter is based on the fitting coefficients of absorption in the case of photoelectric, coherent and incoherent factors. These coefficients are given by Mc Master library or may be determined by the interpolation based on cubic splines

  7. Operation of the HP2250 with the HP9000 series 200 using PASCAL 3.0

    Science.gov (United States)

    Perry, John; Stroud, C. W.

    1986-01-01

    A computer program has been written to provide an interface between the HP Series 200 desktop computers, operating under HP Standard Pascal 3.0, and the HP2250 Data Acquisition and Control System. Pascal 3.0 for the HP9000 desktop computer gives a number of procedures for handling bus communication at various levels. It is necessary, however, to reach the lowest possible level in Pascal to handle the bus protocols required by the HP2250. This makes programming extremely complex since these protocols are not documented. The program described solves those problems and allows the user to immediately program, simply and efficiently, any measurement and control language (MCL/50) application with a few procedure calls. The complete set of procedures is available on a 5 1/4 inch diskette from Cosmic. Included in this group of procedures is an Exerciser which allows the user to exercise his HP2250 interactively. The exerciser operates in a fashion similar to the Series 200 operating system programs, but is adapted to the requirements of the HP2250. The programs on the diskette and the user's manual assume the user is acquainted with both the MCL/50 programming language and HP Standard Pascal 3.0 for the HP series 200 desktop computers.

  8. HP-SEE User Forum 2012

    CERN Document Server

    Karaivanova, Aneta; Oulas, Anastasis; Liabotis, Ioannis; Stojiljkovic, Danica; Prnjat, Ognjen

    2014-01-01

    This book is a collection of carefully reviewed papers presented during the HP-SEE User Forum, the meeting of the High-Performance Computing Infrastructure for South East Europe’s (HP-SEE) Research Communities, held in October 17-19, 2012, in Belgrade, Serbia. HP-SEE aims at supporting and integrating regional HPC infrastructures; implementing solutions for HPC in the region; and making HPC resources available to research communities in SEE, region, which are working in a number of scientific fields with specific needs for massively parallel execution on powerful computing resources. HP-SEE brings together research communities and HPC operators from 14 different countries and enables them to share HPC facilities, software, tools, data and research results, thus fostering collaboration and strengthening the regional and national human network; the project specifically supports research groups in the areas of computational physics, computational chemistry and the life sciences. The contributions presented i...

  9. HP advances Grid Strategy for the adaptive enterprise

    CERN Multimedia

    2003-01-01

    "HP today announced plans to further enable its enterprise infrastructure technologies for grid computing. By leveraging open grid standards, HP plans to help customers simplify the use and management of distributed IT resources. The initiative will integrate industry grid standards, including the Globus Toolkit and Open Grid Services Architecture (OGSA), across HP's enterprise product lines" (1 page).

  10. HP Ge planar detectors

    International Nuclear Information System (INIS)

    Gornov, M.G.; Gurov, Yu.B.; Soldatov, A.M.; Osipenko, B.P.; Yurkowski, J.; Podkopaev, O.I.

    1989-01-01

    Parameters of planar detectors manufactured of HP Ge are presented. The possibilities to use multilayer spectrometers on the base of such semiconductor detectors for nuclear physics experiments are discussed. It is shown that the obtained detectors including high square ones have spectrometrical characteristics close to limiting possible values. 9 refs.; 3 figs.; 1 tab

  11. Goal-Oriented Self-Adaptive hp Finite Element Simulation of 3D DC Borehole Resistivity Simulations

    KAUST Repository

    Calo, Victor M.; Pardo, David; Paszyński, Maciej R.

    2011-01-01

    (adjusting polynomial orders of approximation) or hp (both) refinements on the finite elements. The new parallel implementation utilizes a computational mesh shared between multiple processors. All computational algorithms, including automatic hp goal

  12. COOLII code conversion from Cyber to HP

    International Nuclear Information System (INIS)

    Lee, Hae Cho; Kim, Hee Kyung

    1996-06-01

    COOLII computer code determines the time required to cooldown the plant from shutdown cooling system initiation condition to cold shutdown or refueling condition. Required time for cooldown is calculated under the various assumption on shutdown cooling heat exchanger(SDCHX) availability, reactor coolant system (RCS) low pressure safety injection(LPSI) flowrate. RCS cooldown rates and component cooling system flow rates. This report firstly describes detailed work carried out for installation of COOLII on HP 9000/700 series as well as relevant code validation results. Attached is a report on software verification and validation results. 7 refs. (Author) .new

  13. COAST code conversion from Cyber to HP

    International Nuclear Information System (INIS)

    Lee, Hae Cho

    1996-04-01

    The transient thermal hydraulic behavior of reactor coolant system in a nuclear power plant following loss of coolant flow is analyzed by use of COAST digital computer code. COAST calculates individual loop flow rates and steam generator pressure drops is a function of time following coast-down of any number of reactor coolant pumps. This report firstly describes detailed work carried out for installation of COAST on HP 9000/700 series and code validation results after installation. Secondly, a series of work is also describes in relation to installation of COAST on Apollo DN10000 series as well as relevant code validation results. Attached is a report on software verification and validation results. 7 refs. (Author) .new

  14. Spectral/hp element methods for CFD

    CERN Document Server

    Karniadakis, George Em

    1999-01-01

    Traditionally spectral methods in fluid dynamics were used in direct and large eddy simulations of turbulent flow in simply connected computational domains. The methods are now being applied to more complex geometries, and the spectral/hp element method, which incorporates both multi-domain spectral methods and high-order finite element methods, has been particularly successful. This book provides a comprehensive introduction to these methods. Written by leaders in the field, the book begins with a full explanation of fundamental concepts and implementation issues. It then illustrates how these methods can be applied to advection-diffusion and to incompressible and compressible Navier-Stokes equations. Drawing on both published and unpublished material, the book is an important resource for experienced researchers and for those new to the field.

  15. Spectral/ hp element methods: Recent developments, applications, and perspectives

    Science.gov (United States)

    Xu, Hui; Cantwell, Chris D.; Monteserin, Carlos; Eskilsson, Claes; Engsig-Karup, Allan P.; Sherwin, Spencer J.

    2018-02-01

    The spectral/ hp element method combines the geometric flexibility of the classical h-type finite element technique with the desirable numerical properties of spectral methods, employing high-degree piecewise polynomial basis functions on coarse finite element-type meshes. The spatial approximation is based upon orthogonal polynomials, such as Legendre or Chebychev polynomials, modified to accommodate a C 0 - continuous expansion. Computationally and theoretically, by increasing the polynomial order p, high-precision solutions and fast convergence can be obtained and, in particular, under certain regularity assumptions an exponential reduction in approximation error between numerical and exact solutions can be achieved. This method has now been applied in many simulation studies of both fundamental and practical engineering flows. This paper briefly describes the formulation of the spectral/ hp element method and provides an overview of its application to computational fluid dynamics. In particular, it focuses on the use of the spectral/ hp element method in transitional flows and ocean engineering. Finally, some of the major challenges to be overcome in order to use the spectral/ hp element method in more complex science and engineering applications are discussed.

  16. HP investeerib tulevikku / Fredy-Edwin Esse

    Index Scriptorium Estoniae

    Esse, Fredy-Edwin

    2010-01-01

    Maailma suurima tehnoloogiafirma Hewlett-Packard (HP) tootearenduskulud kasvasid IV kvartalis 16%, 814 mln dollarini. Autor märgib, et HP aktsia on praegu väga hea saak, kuid mingit imehüpet aktsia hinnas ei tuleks kindlasti oodata

  17. Haptoglobin genotyping of Vietnamese: global distribution of HP del, complete deletion allele of the HP gene.

    Science.gov (United States)

    Soejima, Mikiko; Agusa, Tetsuro; Iwata, Hisato; Fujihara, Junko; Kunito, Takashi; Takeshita, Haruo; Lan, Vi Thi Mai; Minh, Tu Binh; Takahashi, Shin; Trang, Pham Thi Kim; Viet, Pham Hung; Tanabe, Shinsuke; Koda, Yoshiro

    2015-01-01

    The haptoglobin (HP) gene deletion allele (HP(del)) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of this allele has been explored by several groups including ours. Here, we studied the frequency of HP(del) in addition to the distribution of common HP genotypes in 293 Vietnamese. The HP(del) was encountered with the frequency of 0.020. The present result suggested that this deletion allele is restricted to East and Southeast Asians. Thus, this allele seems to be a potential ancestry informative marker for these populations. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  18. hp-HGS strategy for inverse 3D DC resistivity logging measurement simulations

    KAUST Repository

    Gajda-Zaǵorska, Ewa

    2012-06-02

    In this paper we present a twin adaptive strategy hp-HGS for solving inverse problems related to 3D DC borehole resistivity measurement simulations. The term “simulation of measurements” is widely used by the geophysical community. A quantity of interest, voltage, is measured at a receiver electrode located in the logging instrument. We use the self-adaptive goal-oriented hp-Finite Element Method (hp-FEM) computer simulations of the process of measurements in deviated wells (when the angle between the borehole and formation layers are < 90 deg). We also employ the hierarchical genetic search (HGS) algorithm to solve the inverse problem. Each individual in the population represents a single configuration of the formation layers. The evaluation of the individual is performed by solving the direct problem by means of the hp-FEM algorithm and by comparison with measured logging curve. We conclude the paper with some discussion on the parallelization of the algorithm.

  19. hp-HGS strategy for inverse 3D DC resistivity logging measurement simulations

    KAUST Repository

    Gajda-Zaǵorska, Ewa; Paszý nski, Maciej; Schaefer, Robert; Pardo, David; Calo, Victor M.

    2012-01-01

    In this paper we present a twin adaptive strategy hp-HGS for solving inverse problems related to 3D DC borehole resistivity measurement simulations. The term “simulation of measurements” is widely used by the geophysical community. A quantity of interest, voltage, is measured at a receiver electrode located in the logging instrument. We use the self-adaptive goal-oriented hp-Finite Element Method (hp-FEM) computer simulations of the process of measurements in deviated wells (when the angle between the borehole and formation layers are < 90 deg). We also employ the hierarchical genetic search (HGS) algorithm to solve the inverse problem. Each individual in the population represents a single configuration of the formation layers. The evaluation of the individual is performed by solving the direct problem by means of the hp-FEM algorithm and by comparison with measured logging curve. We conclude the paper with some discussion on the parallelization of the algorithm.

  20. SGN III code conversion from Apollo to HP

    International Nuclear Information System (INIS)

    Lee, Hae Cho

    1996-04-01

    SGN III computer code is used to analyze transient behavior of reactor coolant system, pressurizer and steam generators in the event of main steam line break (MSLB), and to calculate mass and energy release for containment design. This report firstly describes detailed work carried out for installation of SFN III on Apollo DN 10000 and code validation results after installation. Secondly, a series of work is also describes in relation to installation of SGN III on HP 9000/700 series as well as relevant code validation results. Attached is a report on software verification and validation results. 8 refs. (Author) .new

  1. CONTRANS 2 code conversion from Apollo to HP

    International Nuclear Information System (INIS)

    Lee, Hae Cho

    1996-01-01

    CONTRANS2 computer code is used to calculate transient thermal hydraulic responses of containment building to loss of coolant and main steam line break accident. Mass and energy release to the containment following an accident are code inputs. This report firstly describes detailed work carried out for installation of CONTRANS2 on Apollo DN10000 and code validation results after installation. Secondly, A series of work is also describes in relation to installation of CONTRANS2 on HP 9000/700 series as well as relevant code validation results. Attached is a report on software verification and validation results. 7 refs. (Author) .new

  2. CESEC III code conversion from Apollo to HP9000

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hae Cho [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-01-01

    CESEC code is a computer program used to analyze transient behaviour of reactor coolant systems of nuclear power plants. CESEC III is an extension of original CESEC code in order to apply wide range of accident analysis including ATWS model. Major parameters during the transients are calculated by CESEC. This report firstly describes detailed work carried out for installation of CESEC III on Apollo DN10000 and code validation results after installation. Secondly, A series of work is also described in relation to installation of CESECIII on HP 9000/700 series as well as relevant code validation results. Attached is a report on software verification and validation results. 7 refs. (Author) .new.

  3. CESEC III code conversion from Apollo to HP9000

    International Nuclear Information System (INIS)

    Lee, Hae Cho

    1996-01-01

    CESEC code is a computer program used to analyze transient behaviour of reactor coolant systems of nuclear power plants. CESEC III is an extension of original CESEC code in order to apply wide range of accident analysis including ATWS model. Major parameters during the transients are calculated by CESEC. This report firstly describes detailed work carried out for installation of CESEC III on Apollo DN10000 and code validation results after installation. Secondly, A series of work is also described in relation to installation of CESECIII on HP 9000/700 series as well as relevant code validation results. Attached is a report on software verification and validation results. 7 refs. (Author) .new

  4. Clerget 100 hp heavy-oil engine

    Science.gov (United States)

    Leglise, Pierre

    1931-01-01

    A complete technical description of the Clerget heavy-oil engine is presented along with the general characteristics. The general characteristics are: 9 cylinders, bore 120 mm, stroke 130 mm, four-stroke cycle engine, rated power limited to 100 hp at 1800 rpm; weight 228 kg; propeller with direct drive and air cooling. Moving parts, engine block, and lubrication are all presented.

  5. Spatially adaptive hp refinement approach for PN neutron transport equation using spectral element method

    International Nuclear Information System (INIS)

    Nahavandi, N.; Minuchehr, A.; Zolfaghari, A.; Abbasi, M.

    2015-01-01

    Highlights: • Powerful hp-SEM refinement approach for P N neutron transport equation has been presented. • The method provides great geometrical flexibility and lower computational cost. • There is a capability of using arbitrary high order and non uniform meshes. • Both posteriori and priori local error estimation approaches have been employed. • High accurate results are compared against other common adaptive and uniform grids. - Abstract: In this work we presented the adaptive hp-SEM approach which is obtained from the incorporation of Spectral Element Method (SEM) and adaptive hp refinement. The SEM nodal discretization and hp adaptive grid-refinement for even-parity Boltzmann neutron transport equation creates powerful grid refinement approach with high accuracy solutions. In this regard a computer code has been developed to solve multi-group neutron transport equation in one-dimensional geometry using even-parity transport theory. The spatial dependence of flux has been developed via SEM method with Lobatto orthogonal polynomial. Two commonly error estimation approaches, the posteriori and the priori has been implemented. The incorporation of SEM nodal discretization method and adaptive hp grid refinement leads to high accurate solutions. Coarser meshes efficiency and significant reduction of computer program runtime in comparison with other common refining methods and uniform meshing approaches is tested along several well-known transport benchmarks

  6. Effect of Mutations on HP Lattice Proteins

    Science.gov (United States)

    Shi, Guangjie; Vogel, Thomas; Landau, David; Li, Ying; Wüst, Thomas

    2013-03-01

    Using Wang-Landau sampling with approriate trial moves[2], we investigate the effect of different types of mutations on lattice proteins in the HP model. While exact studies have been carried out for short HP proteins[3], the systems we investigate are of much larger size and hence not accessible for exact enumerations. Based on the estimated density of states, we systematically analyse the changes in structure and degeneracy of ground states of particular proteins and measure thermodynamic quantities like the stability of ground states and the specific heat, for example. Both, neutral mutations, which do not change the structure and stability of ground states, as well as critical mutations, which do change the thermodynamic behavior qualitatively, have been observed. Research supported by NSF

  7. 175Hp contrarotating homopolar motor design report

    Science.gov (United States)

    Cannell, Michael J.; Drake, John L.; McConnell, Richard A.; Martino, William R.

    1994-06-01

    A normally conducting contrarotating homopolar motor has been designed and constructed. The reaction torque, in the outer rotor, from the inner rotor is utilized to produce true contrarotation. The machine utilizes liquid cooled conductors, high performance liquid metal current collectors, and ferrous conductors in the active region. The basic machine output is 175 hp at + or - 1,200 rpm with an input of 4 volts and 35,000 amps.

  8. Optimal design of PV and HP system

    DEFF Research Database (Denmark)

    Nepper-Rasmussen, Bjarke Christian; Rasmussen, Theis Bo

    2015-01-01

    Methods of utilizing residential produced photovoltaic (PV) power by converting to thermal energy through heat pumps (HP) are present in literature, where thermal energy is dispersed as either heat or hot water at the instant moment of PV production. In this paper an alternative solution is descr...... that the thermal storage with a BT is a better investment than a PV system without HP or no investment. Furthermore, it showed that the optimization model developed in this project is capable of finding the optimal combination of component sizes based on our data.......Methods of utilizing residential produced photovoltaic (PV) power by converting to thermal energy through heat pumps (HP) are present in literature, where thermal energy is dispersed as either heat or hot water at the instant moment of PV production. In this paper an alternative solution...... is described, where the thermal energy is stored in a buffer tank (BT) capable of dispersing heat to either the heating system of a house or a hot water tank, for later use. The thermal storage solution including a BT can increase the self-consumption of residentially produced PV power and thereby shift...

  9. DAMT - DISTRIBUTED APPLICATION MONITOR TOOL (HP9000 VERSION)

    Science.gov (United States)

    Keith, B.

    1994-01-01

    processes. The independent processes communicate with each other via UNIX sockets through a Virtual Path router, or Switcher. The Switcher maintains a routing table showing the host of each component process of the tool, eliminating the need for each process to do so. The Central Monitor Complex provides the single application program interface (API) to the user and coordinates the activities of DAMT. The Central Monitor Complex is itself divided into independent objects that perform its functions. The component objects are the Central Monitor, the Process Locator, the Circuit Locator, and the Traffic Reporter. Each of these objects is an independent, asynchronously executing process. User requests to the tool are interpreted by the Central Monitor. The Process Locator identifies whether a named process is running on a monitored host and which host that is. The circuit between any two processes in the distributed application is identified using the Circuit Locator. The Traffic Reporter handles communication with the LAN Analyzer and accumulates traffic updates until it must send a traffic report to the user. The Remote Monitor process is replicated on each monitored host. It serves the Central Monitor Complex processes with application process information. The Remote Monitor process provides access to operating systems information about currently executing processes. It allows the Process Locator to find processes and the Circuit Locator to identify circuits between processes. It also provides lifetime information about currently monitored processes. The LAN Analyzer consists of two processes. Low-level monitoring is handled by the Sniffer. The Sniffer analyzes the raw data on a single, physical LAN. It responds to commands from the Analyzer process, which maintains the interface to the Traffic Reporter and keeps track of which circuits to monitor. DAMT is written in C-language for HP-9000 series computers running HP-UX and Sun 3 and 4 series computers running SunOS. DAMT

  10. One step ahead of technology Cern and HP - an ideal team project

    CERN Multimedia

    Garvey, Kelsey

    2009-01-01

    "In 2004, the It team at Cern recognized the comprehensiveness and future of the LHC Computing Grid Project and realized that the IT infrastructures were not sufficient enough to manage the data. Cern therefore partnered with HP ProCurve the following year to minimize the day-to-day workload and improve infrastructure for data output" (1 page)

  11. A parallel direct solver for the self-adaptive hp Finite Element Method

    KAUST Repository

    Paszyński, Maciej R.

    2010-03-01

    In this paper we present a new parallel multi-frontal direct solver, dedicated for the hp Finite Element Method (hp-FEM). The self-adaptive hp-FEM generates in a fully automatic mode, a sequence of hp-meshes delivering exponential convergence of the error with respect to the number of degrees of freedom (d.o.f.) as well as the CPU time, by performing a sequence of hp refinements starting from an arbitrary initial mesh. The solver constructs an initial elimination tree for an arbitrary initial mesh, and expands the elimination tree each time the mesh is refined. This allows us to keep track of the order of elimination for the solver. The solver also minimizes the memory usage, by de-allocating partial LU factorizations computed during the elimination stage of the solver, and recomputes them for the backward substitution stage, by utilizing only about 10% of the computational time necessary for the original computations. The solver has been tested on 3D Direct Current (DC) borehole resistivity measurement simulations problems. We measure the execution time and memory usage of the solver over a large regular mesh with 1.5 million degrees of freedom as well as on the highly non-regular mesh, generated by the self-adaptive h p-FEM, with finite elements of various sizes and polynomial orders of approximation varying from p = 1 to p = 9. From the presented experiments it follows that the parallel solver scales well up to the maximum number of utilized processors. The limit for the solver scalability is the maximum sequential part of the algorithm: the computations of the partial LU factorizations over the longest path, coming from the root of the elimination tree down to the deepest leaf. © 2009 Elsevier Inc. All rights reserved.

  12. Holomorphic extension of generalizations of Hp functions

    Directory of Open Access Journals (Sweden)

    Richard D. Carmichael

    1985-01-01

    Full Text Available In recent analysis we have defined and studied holomorphic functions in tubes in ℂn which generalize the Hardy Hp functions in tubes. In this paper we consider functions f(z, z=x+iy, which are holomorphic in the tube TC=ℝn+iC, where C is the finite union of open convex cones Cj, j=1,…,m, and which satisfy the norm growth of our new functions. We prove a holomorphic extension theorem in which f(z, z ϵ TC, is shown to be extendable to a function which is holomorphic in T0(C=ℝn+i0(C, where 0(C is the convex hull of C, if the distributional boundary values in 𝒮′ of f(z from each connected component TCj of TC are equal.

  13. Seven health physics calculator programs for the HP-41CV

    International Nuclear Information System (INIS)

    Rittmann, P.D.

    1984-08-01

    Several user-oriented programs for the Hewlett-Packard HP-41CV are explained. The first program builds, stores, alters, and ages a list of radionuclides. This program only handles single- and double-decay chains. The second program performs convenient conversions for the six nuclides of concern in plutonium handling. The conversions are between mass, activity, and weight percents of the isotopes. The source can be aged and/or neutron generation rates can be computed. The third program is a timekeeping program that improves the process of manually estimating and tracking personnel exposure during high dose rate tasks by replacing the pencil, paper, and stopwatch method. This program requires a time module. The remaining four programs deal with computations of time-integrated air concentrations at various distances from an airborne release. Building wake effects, source depletion by ground deposition, and sector averaging can all be included in the final printout of the X/Q - Hanford and X/Q - Pasquill programs. The shorter versions of these, H/Q and P/Q, compute centerline or sector-averaged values and include a subroutine to facilitate dose estimation by entering dose factors and quantities released. The horizontal and vertical dispersion parameters in the Pasquill-Gifford programs were modeled with simple, two-parameter functions that agreed very well with the usual textbook graphs. 8 references, 7 appendices

  14. New approach to calculate the true-coincidence effect of HpGe detector

    Energy Technology Data Exchange (ETDEWEB)

    Alnour, I. A., E-mail: aaibrahim3@live.utm.my, E-mail: ibrahim.elnour@yahoo.com [Department of Physics, Faculty of Pure and Applied Science, International University of Africa, 12223 Khartoum (Sudan); Wagiran, H. [Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Skudai,Johor (Malaysia); Ibrahim, N. [Faculty of Defence Science and Technology, National Defence University of Malaysia, Kem Sungai Besi, 57000 Kuala Lumpur (Malaysia); Hamzah, S.; Elias, M. S. [Malaysia Nuclear Agency (MNA), Bangi, 43000 Kajang, Selangor D.E. (Malaysia); Siong, W. B. [Chemistry Department, Faculty of Resource Science & Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak (Malaysia)

    2016-01-22

    The corrections for true-coincidence effects in HpGe detector are important, especially at low source-to-detector distances. This work established an approach to calculate the true-coincidence effects experimentally for HpGe detectors of type Canberra GC3018 and Ortec GEM25-76-XLB-C, which are in operation at neutron activation analysis lab in Malaysian Nuclear Agency (NM). The correction for true-coincidence effects was performed close to detector at distances 2 and 5 cm using {sup 57}Co, {sup 60}Co, {sup 133}Ba and {sup 137}Cs as standard point sources. The correction factors were ranged between 0.93-1.10 at 2 cm and 0.97-1.00 at 5 cm for Canberra HpGe detector; whereas for Ortec HpGe detector ranged between 0.92-1.13 and 0.95-100 at 2 and 5 cm respectively. The change in efficiency calibration curve of the detector at 2 and 5 cm after correction was found to be less than 1%. Moreover, the polynomial parameters functions were simulated through a computer program, MATLAB in order to find an accurate fit to the experimental data points.

  15. Goal-Oriented Self-Adaptive hp Finite Element Simulation of 3D DC Borehole Resistivity Simulations

    KAUST Repository

    Calo, Victor M.

    2011-05-14

    In this paper we present a goal-oriented self-adaptive hp Finite Element Method (hp-FEM) with shared data structures and a parallel multi-frontal direct solver. The algorithm automatically generates (without any user interaction) a sequence of meshes delivering exponential convergence of a prescribed quantity of interest with respect to the number of degrees of freedom. The sequence of meshes is generated from a given initial mesh, by performing h (breaking elements into smaller elements), p (adjusting polynomial orders of approximation) or hp (both) refinements on the finite elements. The new parallel implementation utilizes a computational mesh shared between multiple processors. All computational algorithms, including automatic hp goal-oriented adaptivity and the solver work fully in parallel. We describe the parallel self-adaptive hp-FEM algorithm with shared computational domain, as well as its efficiency measurements. We apply the methodology described to the three-dimensional simulation of the borehole resistivity measurement of direct current through casing in the presence of invasion.

  16. Animation company "Fast Forwards" production with HP Utility Data Center; film built using Adaptive Enterprise framework enabled by shared, virtual resource

    CERN Multimedia

    2003-01-01

    Hewlett Packard have produced a commercial-quality animated film using an experimental rendering service from HP Labs and running on an HP Utility Data Center (UDC). The project demonstrates how computing resources can be managed virtually and illustrates the value of utility computing, in which an end-user taps into a large pool of virtual resources, but pays only for what is used (1 page).

  17. Modeling of heterogeneous elastic materials by the multiscale hp-adaptive finite element method

    Science.gov (United States)

    Klimczak, Marek; Cecot, Witold

    2018-01-01

    We present an enhancement of the multiscale finite element method (MsFEM) by combining it with the hp-adaptive FEM. Such a discretization-based homogenization technique is a versatile tool for modeling heterogeneous materials with fast oscillating elasticity coefficients. No assumption on periodicity of the domain is required. In order to avoid direct, so-called overkill mesh computations, a coarse mesh with effective stiffness matrices is used and special shape functions are constructed to account for the local heterogeneities at the micro resolution. The automatic adaptivity (hp-type at the macro resolution and h-type at the micro resolution) increases efficiency of computation. In this paper details of the modified MsFEM are presented and a numerical test performed on a Fichera corner domain is presented in order to validate the proposed approach.

  18. 75 FR 62424 - EDS, an HP Company (Re-Branded as HP-Enterprise Services) Including On-Site Workers From: Abel...

    Science.gov (United States)

    2010-10-08

    ...-Branded as HP--Enterprise Services) Including On-Site Workers From: Abel Personnel Inc., Advantage Tech... February 4, 2010, applicable to workers of EDS, an HP Company (Re- branded as HP--Enterprise Services...-branded as HP-- Enterprise Services). These employees provided various activities related to the supply of...

  19. Evaluation of HP0605 and HP0971 genes of efflux pumps in Helicobacter pylori resistance to Metronidazole

    Directory of Open Access Journals (Sweden)

    Mohammad hasan Shirazi

    2009-12-01

    Full Text Available Background: The presence of antibiotic resistance has been reported in H.pylori and it is a major cause of treatment failure. Five families of multidrug efflux pumps are defined in bacteria and resistance-nodulation-division (RND pumps are found mainly in gram negative bacteria. TolC is one of RND pump components and play a critical role in drug resistance. It hasn’t been established that RND family has a role in drug resistance in H.pylori. In this study, we assessed the role of two efflux genes in resistant to metronidazole in H.pylori by evaluation of overexpression TolC genes by RT-PCR method. Methods: In five metronidazole resistant strains of H.pylori, total RNA was extracted. RNA treated with DNase and RNA reverse transcribed to cDNA. Aliquots of the cDNA solution were assayed by RT- PCR for HP0605 and HP0971 genes. The levels of mRNA expression were evaluated by densitometry analysis. Results: All five strains displayed overexpression for HP0605 basis of increased concentration of metronidazole. Three strains showed transcripts for HP0971. One of these had transcripts for HP0971 only in Metronidazole concentration equaled to 16 µg/ml but two strains overexpressed adapt to increase concentration of metronidazole. Conclusion: According to current study, HP0605 and HP0971 genes overexpressed due to increase metronidazole. So, increasing of Metronidazole affects in H.pylori΄s efflux system in transcription level.

  20. An hp symplectic pseudospectral method for nonlinear optimal control

    Science.gov (United States)

    Peng, Haijun; Wang, Xinwei; Li, Mingwu; Chen, Biaosong

    2017-01-01

    An adaptive symplectic pseudospectral method based on the dual variational principle is proposed and is successfully applied to solving nonlinear optimal control problems in this paper. The proposed method satisfies the first order necessary conditions of continuous optimal control problems, also the symplectic property of the original continuous Hamiltonian system is preserved. The original optimal control problem is transferred into a set of nonlinear equations which can be solved easily by Newton-Raphson iterations, and the Jacobian matrix is found to be sparse and symmetric. The proposed method, on one hand, exhibits exponent convergence rates when the number of collocation points are increasing with the fixed number of sub-intervals; on the other hand, exhibits linear convergence rates when the number of sub-intervals is increasing with the fixed number of collocation points. Furthermore, combining with the hp method based on the residual error of dynamic constraints, the proposed method can achieve given precisions in a few iterations. Five examples highlight the high precision and high computational efficiency of the proposed method.

  1. HP fotovõistluse finalistid veebis / Henrik Roonemaa

    Index Scriptorium Estoniae

    Roonemaa, Henrik

    2002-01-01

    Hewlett-Packardi koduleheküljel on üleval rahvusvahelise digitaalfotograafia konkursi HP Invision Digital Photography Awards 2002 finalistide tööd, nende hulgas Katrin Arraku foto "Minu kala Vallo"

  2. An object-oriented decomposition of the adaptive-hp finite element method

    Energy Technology Data Exchange (ETDEWEB)

    Wiley, J.C.

    1994-12-13

    Adaptive-hp methods are those which use a refinement control strategy driven by a local error estimate to locally modify the element size, h, and polynomial order, p. The result is an unstructured mesh in which each node may be associated with a different polynomial order and which generally require complex data structures to implement. Object-oriented design strategies and languages which support them, e.g., C++, help control the complexity of these methods. Here an overview of the major classes and class structure of an adaptive-hp finite element code is described. The essential finite element structure is described in terms of four areas of computation each with its own dynamic characteristics. Implications of converting the code for a distributed-memory parallel environment are also discussed.

  3. Concurrent proinflammatory and apoptotic activity of a Helicobacter pylori protein (HP986 points to its role in chronic persistence.

    Directory of Open Access Journals (Sweden)

    Ayesha Alvi

    Full Text Available Helicobacter pylori induces cytokine mediated changes in gastroduodenal pathophysiology, wherein, the activated macrophages at the sub-mucosal space play a central role in mounting innate immune response against the antigens. The bacterium gains niche through persistent inflammation and local immune-suppression causing peptic ulcer disease or chronic gastritis; the latter being a significant risk factor for the development of gastric adenocarcinoma. What favors persistence of H. pylori in the gastric niches is not clearly understood. We report detailed characterization of a functionally unknown gene (HP986, which was detected in patient isolates associated with peptic ulcer and gastric carcinoma. Expression and purification of recombinant HP986 (rHP986 revealed a novel, ∼29 kDa protein in biologically active form which associates with significant levels of humoral immune responses in diseased individuals (p<0.001. Also, it induced significant levels of TNF-α and Interleukin-8 in cultured human macrophages concurrent to the translocation of nuclear transcription factor-κB (NF-κB. Further, the rHP986 induced apoptosis of cultured macrophages through a Fas mediated pathway. Dissection of the underlying signaling mechanism revealed that rHP986 induces both TNFR1 and Fas expression to lead to apoptosis. We further demonstrated interaction of HP986 with TNFR1 through computational and experimental approaches. Independent proinflammatory and apoptotic responses triggered by rHP986 as shown in this study point to its role, possibly as a survival strategy to gain niche through inflammation and to counter the activated macrophages to avoid clearance.

  4. Tinker-HP: a massively parallel molecular dynamics package for multiscale simulations of large complex systems with advanced point dipole polarizable force fields.

    Science.gov (United States)

    Lagardère, Louis; Jolly, Luc-Henri; Lipparini, Filippo; Aviat, Félix; Stamm, Benjamin; Jing, Zhifeng F; Harger, Matthew; Torabifard, Hedieh; Cisneros, G Andrés; Schnieders, Michael J; Gresh, Nohad; Maday, Yvon; Ren, Pengyu Y; Ponder, Jay W; Piquemal, Jean-Philip

    2018-01-28

    We present Tinker-HP, a massively MPI parallel package dedicated to classical molecular dynamics (MD) and to multiscale simulations, using advanced polarizable force fields (PFF) encompassing distributed multipoles electrostatics. Tinker-HP is an evolution of the popular Tinker package code that conserves its simplicity of use and its reference double precision implementation for CPUs. Grounded on interdisciplinary efforts with applied mathematics, Tinker-HP allows for long polarizable MD simulations on large systems up to millions of atoms. We detail in the paper the newly developed extension of massively parallel 3D spatial decomposition to point dipole polarizable models as well as their coupling to efficient Krylov iterative and non-iterative polarization solvers. The design of the code allows the use of various computer systems ranging from laboratory workstations to modern petascale supercomputers with thousands of cores. Tinker-HP proposes therefore the first high-performance scalable CPU computing environment for the development of next generation point dipole PFFs and for production simulations. Strategies linking Tinker-HP to Quantum Mechanics (QM) in the framework of multiscale polarizable self-consistent QM/MD simulations are also provided. The possibilities, performances and scalability of the software are demonstrated via benchmarks calculations using the polarizable AMOEBA force field on systems ranging from large water boxes of increasing size and ionic liquids to (very) large biosystems encompassing several proteins as well as the complete satellite tobacco mosaic virus and ribosome structures. For small systems, Tinker-HP appears to be competitive with the Tinker-OpenMM GPU implementation of Tinker. As the system size grows, Tinker-HP remains operational thanks to its access to distributed memory and takes advantage of its new algorithmic enabling for stable long timescale polarizable simulations. Overall, a several thousand-fold acceleration over

  5. Switching the JLab Accelerator Operations Environment from an HP-UX Unix-based to a PC/Linux-based environment

    International Nuclear Information System (INIS)

    Mcguckin, Theodore

    2008-01-01

    The Jefferson Lab Accelerator Controls Environment (ACE) was predominantly based on the HP-UX Unix platform from 1987 through the summer of 2004. During this period the Accelerator Machine Control Center (MCC) underwent a major renovation which included introducing Redhat Enterprise Linux machines, first as specialized process servers and then gradually as general login servers. As computer programs and scripts required to run the accelerator were modified, and inherent problems with the HP-UX platform compounded, more development tools became available for use with Linux and the MCC began to be converted over. In May 2008 the last HP-UX Unix login machine was removed from the MCC, leaving only a few Unix-based remote-login servers still available. This presentation will explore the process of converting an operational Control Room environment from the HP-UX to Linux platform as well as the many hurdles that had to be overcome throughout the transition period

  6. On a Weak Discrete Maximum Principle for hp-FEM

    Czech Academy of Sciences Publication Activity Database

    Šolín, Pavel; Vejchodský, Tomáš

    -, č. 209 (2007), s. 54-65 ISSN 0377-0427 R&D Projects: GA ČR(CZ) GA102/05/0629 Institutional research plan: CEZ:AV0Z20570509; CEZ:AV0Z10190503 Keywords : discrete maximum principle * hp-FEM Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.943, year: 2007

  7. Discrete frequency identification using the HP 5451B Fourier analyser

    International Nuclear Information System (INIS)

    Holland, L.; Barry, P.

    1977-01-01

    The frequency analysis by the HP5451B discrete frequency Fourier analyser is studied. The advantages of cross correlation analysis to identify discrete frequencies in a background noise are discussed in conjuction with the elimination of aliasing and wraparound error. Discrete frequency identification is illustrated by a series of graphs giving the results of analysing 'electrical' and 'acoustical' white noise and sinusoidal signals [pt

  8. hp Spectral element methods for three dimensional elliptic problems

    Indian Academy of Sciences (India)

    This is the first of a series of papers devoted to the study of h-p spec- .... element functions defined on mesh elements in the new system of variables with a uni- ... the spectral element functions on these elements and give construction of the stability .... By Hm( ), we denote the usual Sobolev space of integer order m ≥ 0 ...

  9. Nonconforming h-p spectral element methods for elliptic problems

    Indian Academy of Sciences (India)

    In [6,7,13,14] h-p spectral element methods for solving elliptic boundary value problems on polygonal ... Let M denote the number of corner layers and W denote the number of degrees of .... β is given by Theorem 2.2 of [3] which can be stated.

  10. Coupled-Flow Simulation of HP-LP Turbines Has Resulted in Significant Fuel Savings

    Science.gov (United States)

    Veres, Joseph P.

    2001-01-01

    Our objective was to create a high-fidelity Navier-Stokes computer simulation of the flow through the turbines of a modern high-bypass-ratio turbofan engine. The simulation would have to capture the aerodynamic interactions between closely coupled high- and low-pressure turbines. A computer simulation of the flow in the GE90 turbofan engine's high-pressure (HP) and low-pressure (LP) turbines was created at GE Aircraft Engines under contract with the NASA Glenn Research Center. The three-dimensional steady-state computer simulation was performed using Glenn's average-passage approach named APNASA. The areas upstream and downstream of each blade row mutually interact with each other during engine operation. The embedded blade row operating conditions are modeled since the average passage equations in APNASA actively include the effects of the adjacent blade rows. The turbine airfoils, platforms, and casing are actively cooled by compressor bleed air. Hot gas leaks around the tips of rotors through labyrinth seals. The flow exiting the high work HP turbines is partially transonic and, therefore, has a strong shock system in the transition region. The simulation was done using 121 processors of a Silicon Graphics Origin 2000 (NAS 02K) cluster at the NASA Ames Research Center, with a parallel efficiency of 87 percent in 15 hr. The typical average-passage analysis mesh size per blade row was 280 by 45 by 55, or approx.700,000 grid points. The total number of blade rows was 18 for a combined HP and LP turbine system including the struts in the transition duct and exit guide vane, which contain 12.6 million grid points. Design cycle turnaround time requirements ran typically from 24 to 48 hr of wall clock time. The number of iterations for convergence was 10,000 at 8.03x10(exp -5) sec/iteration/grid point (NAS O2K). Parallel processing by up to 40 processors is required to meet the design cycle time constraints. This is the first-ever flow simulation of an HP and LP

  11. Comparative analysis of the folding dynamics and kinetics of an engineered knotted protein and its variants derived from HP0242 of Helicobacter pylori

    Science.gov (United States)

    Wang, Liang-Wei; Liu, Yu-Nan; Lyu, Ping-Chiang; Jackson, Sophie E.; Hsu, Shang-Te Danny

    2015-09-01

    Understanding the mechanism by which a polypeptide chain thread itself spontaneously to attain a knotted conformation has been a major challenge in the field of protein folding. HP0242 is a homodimeric protein from Helicobacter pylori with intertwined helices to form a unique pseudo-knotted folding topology. A tandem HP0242 repeat has been constructed to become the first engineered trefoil-knotted protein. Its small size renders it a model system for computational analyses to examine its folding and knotting pathways. Here we report a multi-parametric study on the folding stability and kinetics of a library of HP0242 variants, including the trefoil-knotted tandem HP0242 repeat, using far-UV circular dichroism and fluorescence spectroscopy. Equilibrium chemical denaturation of HP0242 variants shows the presence of highly populated dimeric and structurally heterogeneous folding intermediates. Such equilibrium folding intermediates retain significant amount of helical structures except those at the N- and C-terminal regions in the native structure. Stopped-flow fluorescence measurements of HP0242 variants show that spontaneous refolding into knotted structures can be achieved within seconds, which is several orders of magnitude faster than previously observed for other knotted proteins. Nevertheless, the complex chevron plots indicate that HP0242 variants are prone to misfold into kinetic traps, leading to severely rolled-over refolding arms. The experimental observations are in general agreement with the previously reported molecular dynamics simulations. Based on our results, kinetic folding pathways are proposed to qualitatively describe the complex folding processes of HP0242 variants.

  12. A Chaotic Oscillator Based on HP Memristor Model

    Directory of Open Access Journals (Sweden)

    Guangyi Wang

    2015-01-01

    Full Text Available This paper proposes a simple autonomous memristor-based oscillator for generating periodic signals. Applying an external sinusoidal excitation to the autonomous system, a nonautonomous oscillator is obtained, which contains HP memristor model and four linear circuit elements. This memristor-based oscillator can generate periodic, chaotic, and hyperchaotic signals under the periodic excitation and an appropriate set of circuit parameters. It also shows that the system exhibits alternately a hidden attractor with no equilibrium and a self-excited attractor with a line equilibrium as time goes on. Furthermore, some specialties including burst chaos, irregular periodic bifurcations, and nonintermittence chaos of the circuit are found by theoretical analysis and numerical simulations. Finally, a discrete model for the HP memristor is given and the main statistical properties of this memristor-based oscillator are verified via DSP chip experiments and NIST (National Institute of Standards and Technology tests.

  13. Vibration and Stability of 3000-hp, Titanium Chemical Process Blower

    Directory of Open Access Journals (Sweden)

    Les Gutzwiller

    2003-01-01

    Full Text Available This 74-in-diameter blower had an overhung rotor design of titanium construction, operating at 50 pounds per square inch gauge in a critical chemical plant process. The shaft was supported by oil-film bearings and was directdriven by a 3000-hp electric motor through a metal disk type of coupling. The operating speed was 1780 rpm. The blower shaft and motor shaft motion was monitored by Bently Nevada proximity probes and a Model 3100 monitoring system.

  14. 78 FR 48468 - Hewlett Packard Company, Hewlett Packard Enterprise Business Unit, EG HP Storage, Enterprise...

    Science.gov (United States)

    2013-08-08

    ..., Hewlett Packard Enterprise Business Unit, EG HP Storage, Enterprise Storage, Servers and Networking Storage, APP Management, Research and Development Group, Andover, Massachusetts; Notice of Investigation... Enterprise Business Unit, EG HP Storage, Enterprise Storage, Servers and Networking Storage Division, APP...

  15. Plasma disruption forces: a program for the HP 9845 and 9872 B plotter

    International Nuclear Information System (INIS)

    Foss, M.H.

    1982-11-01

    A computer program is described for the calculation of currents, forces, torques, and voltages in the conducting first wall and limiter of a tokamak reactor experiencing a plasma quench. Instructions are given for running the program on a HP 9845 B desk-top computer with a 9872 B plotter. The first wall and limiter have been modelled by 44 coaxial loops. The inductance matrix among the loops is calculated, and the currents in them are calculated step-by-step over time, driven by the flux from the decaying plasma current and subject to the field from the plasma, from the poloidal field coils, and from all current loops. An insulating break in the limiter or first wall can be modelled by imposing a back voltage which causes all the currents in the limiter or first wall to sum to zero. This potential is related to the voltage between segments of a segmented limiter or first wall

  16. hp-version discontinuous Galerkin methods on polygonal and polyhedral meshes

    CERN Document Server

    Cangiani, Andrea; Georgoulis, Emmanuil H; Houston, Paul

    2017-01-01

    Over the last few decades discontinuous Galerkin finite element methods (DGFEMs) have been witnessed tremendous interest as a computational framework for the numerical solution of partial differential equations. Their success is due to their extreme versatility in the design of the underlying meshes and local basis functions, while retaining key features of both (classical) finite element and finite volume methods. Somewhat surprisingly, DGFEMs on general tessellations consisting of polygonal (in 2D) or polyhedral (in 3D) element shapes have received little attention within the literature, despite the potential computational advantages. This volume introduces the basic principles of hp-version (i.e., locally varying mesh-size and polynomial order) DGFEMs over meshes consisting of polygonal or polyhedral element shapes, presents their error analysis, and includes an extensive collection of numerical experiments. The extreme flexibility provided by the locally variable elemen t-shapes, element-sizes, and elemen...

  17. Conversion of the COBRA-IV-I code from CDC CYBER to HP 9000/700 version

    International Nuclear Information System (INIS)

    Sohn, D. S.; Yoo, Y. J.; Nahm, K. Y.; Hwang, D. H.

    1996-01-01

    COBRA-IV-I is a multichannel analysis code for the thermal-hydraulic analysis of rod bundle nuclear fuel elements and cores based on the subchannel approach. The existing COBRA-IV-I code is the control data corporation (CDC) CYBER version, which has limitations on the computer core storage and gives some inconvenience to the user interface. To solve these problems, we have converted the COBRA-IV-I code form the CDC CYBER mainframe to an Hewlett Packard (HP) 9000/700-series workstation version, and have verified the converted code. as a result, we have found almost no difference between the two versions in their calculation results. Therefore we expect the HP 9000/700 version of the COBRA-IV-I code to be the basis for the future development of an improved multichannel analysis code under the more convenient user environment. (author). 3 tabs., 2 figs., 8 refs

  18. Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin

    Czech Academy of Sciences Publication Activity Database

    Legartová, Soňa; Jugová, Alžbeta; Stixová, Lenka; Kozubek, Stanislav; Fojtová, Miloslava; Zdráhal, Z.; Lochmanová, G.; Bártová, Eva

    2013-01-01

    Roč. 95, č. 2 (2013), s. 167-179 ISSN 0300-9084 R&D Projects: GA ČR(CZ) GAP302/10/1022; GA ČR(CZ) GBP302/12/G157; GA MŠk(CZ) LD11020; GA MŠk(CZ) ED1.1.00/02.0068 Institutional research plan: CEZ:AV0Z50040702 Institutional support: RVO:68081707 Keywords : Apoptosis * Histones * HP1 Subject RIV: BO - Biophysics Impact factor: 3.123, year: 2013

  19. Perspectives on Industrial Innovation from Agilent, HP, and Bell Labs

    Science.gov (United States)

    Hollenhorst, James

    2014-03-01

    Innovation is the life blood of technology companies. I will give perspectives gleaned from a career in research and development at Bell Labs, HP Labs, and Agilent Labs, from the point of view of an individual contributor and a manager. Physicists bring a unique set of skills to the corporate environment, including a desire to understand the fundamentals, a solid foundation in physical principles, expertise in applied mathematics, and most importantly, an attitude: namely, that hard problems can be solved by breaking them into manageable pieces. In my experience, hiring managers in industry seldom explicitly search for physicists, but they want people with those skills.

  20. Structural effects at Λ3Hp-scattering

    International Nuclear Information System (INIS)

    Tartakovskij, V.K.; Fursaev, A.V.; Ivanova, O.I.

    2003-01-01

    In the paper the calculated dependences of falling hyper-tritons energy E=156 MeV differential cross sections from the scattering angle in the center of mass system θ and for more high energy values E from coupling energy ε 0 of Λ 3 H with regard to its disintegration into Λ-hyperon and deuteron are presented. It is established the strong dependence of differential cross section from ε 0 , moreover the sensitivity of differential cross sections to ε 0 value grows up with increasing of energy E. This allows to use the Λ 3 Hp-scattering as a method for ε 0 value elaboration

  1. Hp Ge: Purification, crystal growth, and annealing properties

    International Nuclear Information System (INIS)

    Hall, R.N.

    1984-01-01

    The prospects for growing HP Ge crystals of increased size and purity are examined. One interesting approach is to grow dislocation-free crystals, which must then be annealed to reduce the concentration of V 2 H traps. The phenomena which occur during annealing are discussed and compared with experiment. Hydrogen, present in atomic form at the growth temperature, forms H 2 molecules during cooling, causing the effective diffusion coefficient to decrease rapidly. Models representing the reactions between H and the V 2 H, A(H, Si), and D(H,O) complexes are presented and analyzed

  2. PULSION registered HP: Tunable, High Productivity Plasma Doping

    International Nuclear Information System (INIS)

    Felch, S. B.; Torregrosa, F.; Etienne, H.; Spiegel, Y.; Roux, L.; Turnbaugh, D.

    2011-01-01

    Plasma doping has been explored for many implant applications for over two decades and is now being used in semiconductor manufacturing for two applications: DRAM polysilicon counter-doping and contact doping. The PULSION HP is a new plasma doping tool developed by Ion Beam Services for high-volume production that enables customer control of the dominant mechanism--deposition, implant, or etch. The key features of this tool are a proprietary, remote RF plasma source that enables a high density plasma with low chamber pressure, resulting in a wide process space, and special chamber and wafer electrode designs that optimize doping uniformity.

  3. Thermal stress state of cryogenic HP vessels under freezing and pressurization

    International Nuclear Information System (INIS)

    Tsybenko, A.S.; Kuranov, B.A.; Chepurnoj, A.D.; Shaposhnikov, V.A.; Krishchuk, N.G.

    1986-01-01

    A mathematical model is developed for thermomechanical processes in cryogenic HP vessels under freezing either by liquid and (or) gaseous cryogen and under pressurization. Equations of nonlinear nonstationary thermal conductivity and nonisothermal thermoelastoplasticity are used for the case of the theory off low with isotropic hardening. Semiempiricaldependences of nonstationary heat exchange for gaseous medium, experimental curves of cryogenic liquid boiling, mass exchange relationships are allowed for when formulating boundary conditions. The mathematical modelis realized on the basi of the finite element method in the form of highly automated program complex TERSOD (heat resistanceof vessels), oriented for computer of the Unified System. Heat and stress-strained states for three constructions of vessels are thoroughly studied under different conditions of gaseous, liquid and combined freezing with subsequent pressurization

  4. Analysis of HP1α regulation in human breast cancer cells

    DEFF Research Database (Denmark)

    Thomsen, Rune; Christensen, Dennis B; Rosborg, Sanne

    2011-01-01

    The three mammalian HP1 proteins, HP1α/CBX5, HP1β/CBX1, and HPγ/CBX3, are involved in chromatin packing and gene regulation. The HP1α protein is down-regulated in invasive compared to non-invasive breast cancer cells and HP1α is a suppressor of cell migration and invasion. In this report, we...... examined the background for HP1α protein down-regulation in invasive breast cancer cells. We identified a strict correlation between HP1α down-regulation at the protein level and the mRNA level. The HP1α mRNA down-regulation in invasive cancer cells was not caused by mRNA destabilization. Chromatin...... immunoprecipitation analysis of the HP1α gene showed a decrease in the histone mark for transcriptional activity H3-K36 tri-methylation and RNA polymerase II in invasive breast cancer cells which correlated with a decreased abundance of basal transcription factors at the HP1α promoter. E2F transcription factors...

  5. A replica exchange Monte Carlo algorithm for protein folding in the HP model

    Directory of Open Access Journals (Sweden)

    Shmygelska Alena

    2007-09-01

    Full Text Available Abstract Background The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of the most important and challenging problems in biochemistry, molecular biology and biophysics. The ab initio protein folding problem is computationally challenging and has been shown to be NP MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFneVtcqqGqbauaaa@3961@-hard even when conformations are restricted to a lattice. In this work, we implement and evaluate the replica exchange Monte Carlo (REMC method, which has already been applied very successfully to more complex protein models and other optimization problems with complex energy landscapes, in combination with the highly effective pull move neighbourhood in two widely studied Hydrophobic Polar (HP lattice models. Results We demonstrate that REMC is highly effective for solving instances of the square (2D and cubic (3D HP protein folding problem. When using the pull move neighbourhood, REMC outperforms current state-of-the-art algorithms for most benchmark instances. Additionally, we show that this new algorithm provides a larger ensemble of ground-state structures than the existing state-of-the-art methods. Furthermore, it scales well with sequence length, and it finds significantly better conformations on long biological sequences and sequences with a provably unique ground-state structure, which is believed to be a characteristic of real proteins. We also present evidence that our REMC algorithm can fold sequences which exhibit significant interaction between termini in the hydrophobic core relatively easily. Conclusion We demonstrate that REMC utilizing the pull move

  6. Clinical value of 13C-UBT diagnosing infection of the Hp

    International Nuclear Information System (INIS)

    Xu Changde; Chen Shaoliang; Liu Wenguan

    2004-01-01

    100 dyspeptic patients are performed an endoscopy with biopsy for histology, rapid urease test, 13 C-urea breath test( 13 C-UBT) and ASSURE TM Hp rapid Test(HpRT). Patients are considered to be infected if both histology and biopsies yield positive results, and not infected when both tests are negative. The pathology and persons responsible for endoscopy, urease test and 13 C-UBT are unaware of the results from the other diagnostic methods. The 13 C-UBT has the following results: sensitivity 96% ,specificity 95%; rapid urease test has the following results: sensitivity 79%, specificity 76%; HpRT has the following results: sensitivity 86%, specificity 88%. 13 C-UBT provides excellent sensitivity and specificity for the diagnosis of Hp. Pylori infected Hp, it can be the first choice for detecting the infection of the Hp. (authors)

  7. HP Memristor mathematical model for periodic signals and DC

    KAUST Repository

    Radwan, Ahmed G.

    2012-07-28

    In this paper mathematical models of the HP Memristor for DC and periodic signal inputs are provided. The need for a rigid model for the Memristor using conventional current and voltage quantities is essential for the development of many promising Memristors\\' applications. Unlike the previous works, which focuses on the sinusoidal input waveform, we derived rules for any periodic signals in general in terms of voltage and current. Square and triangle waveforms are studied explicitly, extending the formulas for any general square wave. The limiting conditions for saturation are also provided in case of either DC or periodic signals. The derived equations are compared to the SPICE model of the Memristor showing a perfect match.

  8. A nonlinear HP-type complementary resistive switch

    Directory of Open Access Journals (Sweden)

    Paul K. Radtke

    2016-05-01

    Full Text Available Resistive Switching (RS is the change in resistance of a dielectric under the influence of an external current or electric field. This change is non-volatile, and the basis of both the memristor and resistive random access memory. In the latter, high integration densities favor the anti-serial combination of two RS-elements to a single cell, termed the complementary resistive switch (CRS. Motivated by the irregular shape of the filament protruding into the device, we suggest a nonlinearity in the resistance-interpolation function, characterized by a single parameter p. Thereby the original HP-memristor is expanded upon. We numerically simulate and analytically solve this model. Further, the nonlinearity allows for its application to the CRS.

  9. A nonlinear HP-type complementary resistive switch

    Science.gov (United States)

    Radtke, Paul K.; Schimansky-Geier, Lutz

    2016-05-01

    Resistive Switching (RS) is the change in resistance of a dielectric under the influence of an external current or electric field. This change is non-volatile, and the basis of both the memristor and resistive random access memory. In the latter, high integration densities favor the anti-serial combination of two RS-elements to a single cell, termed the complementary resistive switch (CRS). Motivated by the irregular shape of the filament protruding into the device, we suggest a nonlinearity in the resistance-interpolation function, characterized by a single parameter p. Thereby the original HP-memristor is expanded upon. We numerically simulate and analytically solve this model. Further, the nonlinearity allows for its application to the CRS.

  10. High-resolution mapping reveals links of HP1 with active and inactive chromatin components.

    Directory of Open Access Journals (Sweden)

    Elzo de Wit

    2007-03-01

    Full Text Available Heterochromatin protein 1 (HP1 is commonly seen as a key factor of repressive heterochromatin, even though a few genes are known to require HP1-chromatin for their expression. To obtain insight into the targeting of HP1 and its interplay with other chromatin components, we have mapped HP1-binding sites on Chromosomes 2 and 4 in Drosophila Kc cells using high-density oligonucleotide arrays and the DNA adenine methyltransferase identification (DamID technique. The resulting high-resolution maps show that HP1 forms large domains in pericentric regions, but is targeted to single genes on chromosome arms. Intriguingly, HP1 shows a striking preference for exon-dense genes on chromosome arms. Furthermore, HP1 binds along entire transcription units, except for 5' regions. Comparison with expression data shows that most of these genes are actively transcribed. HP1 target genes are also marked by the histone variant H3.3 and dimethylated histone 3 lysine 4 (H3K4me2, which are both typical of active chromatin. Interestingly, H3.3 deposition, which is usually observed along entire transcription units, is limited to the 5' ends of HP1-bound genes. Thus, H3.3 and HP1 are mutually exclusive marks on active chromatin. Additionally, we observed that HP1-chromatin and Polycomb-chromatin are nonoverlapping, but often closely juxtaposed, suggesting an interplay between both types of chromatin. These results demonstrate that HP1-chromatin is transcriptionally active and has extensive links with several other chromatin components.

  11. Frequency of helicobacter pylori (hp) infection in children with recurrent abdominal pain (rap)

    International Nuclear Information System (INIS)

    Mahmud, S.; Ali, S.

    2015-01-01

    To study the frequency of Helicobacter Pylori (HP) infection among children with recurrent abdominal pain (RAP) Study Design: Cross-sectional comparative study. Place and Duration of Study: Military Hospital (MH), Rawalpindi from December 2011 to February 2012. Patients and Methods: One hundred children of either gender aged 2 to 12 years presenting with RAP were tested for HP at Paediatric OPD MH, Rawalpindi who consented to participate in the study. Those children who tested positive for Helicobacter Pylori Stool Antigen Test (HPSAT) were labeled as those having Hp infection. The stool assay was performed using the HpSAT kit and the socio-demographic and clinical profiles of children were associated. Results: Out of 100 children included in the study HpSAT was positive in 38% children. Frequency of Hp infection was significantly associated with source of drinking water (p = 0.014), socioeconomic status (p = 0.001) and positive family history of yspepsia (p= 0.023). While age and gender have no significant association with HP infection. Conclusion: Hp infection is very common in children presenting with RAP in our Paediatric OPD. Children with family history of dyspepsia, from low socioeconomic class and those drinking filtered water are at greater risk for HP infection. It is recommended that children from other populations in our country should also be tested in their medical health facilities in order to have a wider analysis of this problem in our setup. (author)

  12. Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours

    DEFF Research Database (Denmark)

    Bartkova, J; Moudry, P; Hodny, Z

    2011-01-01

    activation in CIS; and enhanced HP1α in teratoma structures with epithelial and neuronal differentiation. Differential expression of the three heterochromatin markers suggests their partly non-overlapping roles, and separation of heterochromatinization from DDR activation highlights distinct responses...

  13. Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression.

    Directory of Open Access Journals (Sweden)

    Marc Lavigne

    2009-12-01

    Full Text Available The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain. The chromo-domain binds histone H3 tails methylated on lysine 9. However, in vivo and in vitro experiments have shown that the affinity of HP1 proteins to native methylated chromatin is relatively poor and that the opening of chromatin occurring during DNA replication facilitates their binding to nucleosomes. These observations prompted us to investigate whether HP1 proteins have additional histone binding activities, envisioning also affinity for regions potentially occluded by the nucleosome structure. We find that the chromoshadow-domain interacts with histone H3 in a region located partially inside the nucleosomal barrel at the entry/exit point of the nucleosome. Interestingly, this region is also contacted by the catalytic subunits of the human SWI/SNF complex. In vitro, efficient SWI/SNF remodeling requires this contact and is inhibited in the presence of HP1 proteins. The antagonism between SWI/SNF and HP1 proteins is also observed in vivo on a series of interferon-regulated genes. Finally, we show that SWI/SNF activity favors loading of HP1 proteins to chromatin both in vivo and in vitro. Altogether, our data suggest that HP1 chromoshadow-domains can benefit from the opening of nucleosomal structures to bind chromatin and that HP1 proteins use this property to detect and arrest unwanted chromatin remodeling.

  14. The transport kinetics and selectivity of HpUreI, the urea channel from Helicobacter pylori†

    Science.gov (United States)

    Gray, Lawrence R; Gu, Sean X; Quick, Matthias; Khademi, Shahram

    2017-01-01

    Helicobacter pylori’s unique ability to colonize and survive in the acidic environment of the stomach is critically dependent on uptake of urea through the urea channel, HpUreI. Hence, HpUreI may represent a promising target for the development of specific drugs against this human pathogen. To obtain insight into the structure/function relationship of this channel, we have developed conditions for the high-yield expression and purification of stable recombinant HpUreI that allowed its detailed kinetic characterization in solubilized form and reconstituted into liposomes. Detergent-solubilized HpUreI forms homo-trimer, as determined by chemical cross-linking. Urea dissociation kinetics of purified HpUreI were determined by means of the scintillation proximity assay (SPA), whereas urea efflux was measured in HpUreI-containing proteoliposomes using stopped-flow spectrometry to determine the kinetics and selectivity of the urea channel. The kinetic analyses revealed that urea conduction in HpUreI is pH sensitive and saturable with a half-saturation concentration (or K0.5) of ~163 mM. Binding of urea by HpUreI was increased at lower pH; however, the apparent affinity of urea binding (~150 mM) was not significantly pH dependent. The solute selectivity analysis indicated that HpUreI is highly selective for urea and hydroxyurea. Removing either amino group of urea molecules diminishes their permeability through HpUreI. Similar to urea conduction, water diffusion through HpUreI is pH-dependent with low water permeability at neutral pH. PMID:21877689

  15. HP1γ function is required for male germ cell survival and spermatogenesis

    Directory of Open Access Journals (Sweden)

    Brown Jeremy P

    2010-04-01

    Full Text Available Abstract Background HP1 proteins are conserved components of eukaryotic constitutive heterochromatin. In mammals, there are three genes that encode HP1-like proteins, termed HP1α, HP1β and HP1γ, which have a high degree of homology This paper describes for the first time, to our knowledge, the physiological function of HP1γ using a gene-targeted mouse. Results While targeting the Cbx3 gene (encoding the HP1γ protein with a conditional targeting vector, we generated a hypomorphic allele (Cbx3hypo, which resulted in much reduced (barely detectable levels of HP1γ protein. Homozygotes for the hypomorphic allele (Cbx3hypo/hypo are rare, with only 1% of Cbx3hypo/hypo animals reaching adulthood. Adult males exhibit a severe hypogonadism that is associated with a loss of germ cells, with some seminiferous tubules retaining only the supporting Sertoli cells (Sertoli cell-only phenotype. The percentage of seminiferous tubules that are positive for L1 ORF1 protein (ORF1p in Cbx3hypo/hypo testes is greater than that for wild-type testes, indicating that L1 retrotransposon silencing is reversed, leading to ectopic expression of ORF1p in Cbx3hypo/hypo germ cells. Conclusions The Cbx3 gene product (the HP1γ protein has a non-redundant function during spermatogenesis that cannot be compensated for by the other two HP1 isotypes. The Cbx3hypo/hypo spermatogenesis defect is similar to that found in Miwi2 and Dnmt3L mutants. The Cbx3 gene-targeted mice generated in this study provide an appropriate model for the study of HP1γ in transposon silencing and parental imprinting.

  16. Software quality assurance documentation for the release of NUFT 2.0 for HP platforms

    International Nuclear Information System (INIS)

    Fernandez, M.W.; Preckshot, G.G.; Johnson, G.L.

    1998-01-01

    This document is the Individual Software Plan (ISP) for version 2.0 of the Non-isothermal Unsaturated-saturated Flow and Transport (NUFT.) analysis computer program. This document addresses the applicable requirements of LLNL YMP procedure 033-YMP-QP 3.2, Section 4.2.1.1. The purpose of this ISP is to plan and organize the activities required to certify the NUFT code for quality affecting work involving problems that include cross drift analysis of the Yucca Mountain Repository facility. NUFT is software for application to the solution of a class of coupled mass and heat transport problems in porous geologic media including Yucca Mountain Repository Cross Drift Problem (YMRCDP- also known as the Enhanced Characterization of the Repository Block (ECRB)). Solution of this class of problems requires a suite of multiphase, multi-component models for numerical solution of non- isothermal flow and transport in porous media with applications to subsurface contaminant transport problems. NUFT is a suite of multiphase, multi-component models for numerical solution of non- isothermal flow and transport in porous media, with application to subsurface contaminant transport problems, and in particular, to the hydrology in and about the Yucca Mountain Repository Site. NUFI is acquired software, as defined by 033-YMP-QP 3.2, and a preliminary baseline of source code, electronic documentation, and paper documentation has been established as required by 033-YMP-QP 3.2, Section 4.1. NUFT runs on Sun Unix platforms, Solaris operating system version 5.5 and HP-UX with operating system version 10.20. The product to be qualified under this ISP is the version running on HP- UX. The HP version will be labeled Version 2.0h. The h is included to distinguish the HP version from possible future versions qualified for Sun or other platforms. The scope of the plans and procedures outlined in this ISP is limited to the effort required to qualify NUFT for the class of problems identified in

  17. Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung.

    Science.gov (United States)

    Abdullah, Mahdi; Goldmann, Torsten

    2012-11-20

    Since the existence of pHp was demonstrated, it has been shown that this molecule and its receptor CD163 are regulated by different stimuli. Furthermore, a comparably fast secretion of pHp was described as well as the immuno-stimulatory effects. The intention of this study was to elucidate the role of pHp in the human lungs further. Here we show, by means of confocal microscopy and immune-electron-microscopy, a clear co-localization of pHp with surfactant protein-B in lamellar bodies of alveolar epithelial cells type II. These results are underlined by immunohistochemical stainings in differently fixed human lung tissues, which show pHp in vesicular and released form. The images of the released form resemble the intended position of surfactant in the human alveolus. pHp is secreted by Alveolar epithelial cells type II as previously shown. Moreover, pHp is co-localized with Surfactant protein-B. We conclude that the presented data shows that pHp is a native part of the surfactant system in the human lung. http://www.diagnosticpathology.diagnomx.eu/vs/2563584738239912.

  18. The CompHP Core Competencies Framework for Health Promotion in Europe

    Science.gov (United States)

    Barry, Margaret M.; Battel-Kirk, Barbara; Dempsey, Colette

    2012-01-01

    Background: The CompHP Project on Developing Competencies and Professional Standards for Health Promotion in Europe was developed in response to the need for new and changing health promotion competencies to address health challenges. This article presents the process of developing the CompHP Core Competencies Framework for Health Promotion across…

  19. Urinary 1-hydroxypyrene (1-HP) in environmental and occupational studies--a review

    DEFF Research Database (Denmark)

    Hansen, Ase M; Mathiesen, Line; Pedersen, Marie

    2008-01-01

    , volume (and time) or concentrations of creatinine are often used to standardize for diuresis. To be able to compare the included studies we recalculated the given concentrations to mumol 1-HP/mol creatinine. In conclusion, the highest concentrations of urinary 1-HP are found among workers...

  20. Analysis of the human HP1 interactome reveals novel binding partners

    DEFF Research Database (Denmark)

    Rosnoblet, Claire; Vandamme, Julien; Völkel, Pamela

    2011-01-01

    Heterochromatin protein 1 (HP1) has first been described in Drosophila as an essential component of constitutive heterochromatin required for stable epigenetic gene silencing. Less is known about the three mammalian HP1 isotypes CBX1, CBX3 and CBX5. Here, we applied a tandem affinity purification...

  1. FLOOD 3 code conversion from Apollo to HP

    International Nuclear Information System (INIS)

    Lee, Hae Cho

    1996-01-01

    FLOOD3 is a Fortran program used to analyze LOCA Reflood and Post Reflood transients for purpose of mechanistically generating containment sizing mass/energy source terms. The reflood time frame starts when safety injection water first enters the bottom of the core, following the initial LOCA blowdown phase, and the ends when liquid level in the core is high enough to quench the core. The post reflood phase starts at the end of reflood phase and lasts until the end of LOCA transient period. Longterm core cooling is initiated following post reflood phase. FLOOD3 code dose not contain separate capability for longterm cooling analysis. This report firstly describes detailed work carried out for installation of FLOOD3 on Apollo DN10000 and code validation results after installation. Secondly, A series of work is also describes in relation to installation of FLOOD3 on HP 9000/700 series as well as relevant code validation results. Attached is a report on software verification and validation results. 7 refs. (Author) .new

  2. FLOOD 3 code conversion from Apollo to HP

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hae Cho [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-01-01

    FLOOD3 is a Fortran program used to analyze LOCA Reflood and Post Reflood transients for purpose of mechanistically generating containment sizing mass/energy source terms. The reflood time frame starts when safety injection water first enters the bottom of the core, following the initial LOCA blowdown phase, and the ends when liquid level in the core is high enough to quench the core. The post reflood phase starts at the end of reflood phase and lasts until the end of LOCA transient period. Longterm core cooling is initiated following post reflood phase. FLOOD3 code dose not contain separate capability for longterm cooling analysis. This report firstly describes detailed work carried out for installation of FLOOD3 on Apollo DN10000 and code validation results after installation. Secondly, A series of work is also describes in relation to installation of FLOOD3 on HP 9000/700 series as well as relevant code validation results. Attached is a report on software verification and validation results. 7 refs. (Author) .new.

  3. MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation

    Science.gov (United States)

    Agarwal, Noopur; Hardt, Tanja; Brero, Alessandro; Nowak, Danny; Rothbauer, Ulrich; Becker, Annette; Leonhardt, Heinrich; Cardoso, M. Cristina

    2007-01-01

    There is increasing evidence of crosstalk between epigenetic modifications such as histone and DNA methylation, recognized by HP1 and methyl CpG-binding proteins, respectively. We have previously shown that the level of methyl CpG-binding proteins increased dramatically during myogenesis leading to large-scale heterochromatin reorganization. In this work, we show that the level of HP1 isoforms did not change significantly throughout myogenic differentiation but their localization did. In particular, HP1γ relocalization to heterochromatin correlated with MeCP2 presence. Using co-immunoprecipitation assays, we found that these heterochromatic factors interact in vivo via the chromo shadow domain of HP1 and the first 55 amino acids of MeCP2. We propose that this dynamic interaction of HP1 and MeCP2 increases their concentration at heterochromatin linking two major gene silencing pathways to stabilize transcriptional repression during differentiation. PMID:17698499

  4. Influence of the geometrical characteristics of an HpGe detector on its efficiency

    International Nuclear Information System (INIS)

    Vargas, M.J.; Timon, A.F.; Sanchez, D.P.

    2002-01-01

    Computer codes based on Monte Carlo calculations have been extensively developed for the computation of the efficiency in gamma-ray spectrometry. The errors in the specific parameters of the detector due to the lack of precise knowledge of its characteristics usually represent one of the most important sources of inaccuracy in this simulation technique. Influence of several detector parameters on the efficiency for a typical coaxial n-type HpGe detector is presented. Calculations of the full-energy peak efficiencies were performed by means of a Monte Carlo code in the range 122-1836 keV for several types of source configuration: point source, cellulose filter, and two different cylindrical boxes containing a solid matrix of SiO 2 . The detector parameters varied were the crystal diameter, crystal height, diameter of the internal core, and the position of the crystal with respect to the beryllium window. Significant deviations in the efficiency, depending on the source geometry and the photon energy, can be produced by varying only slightly some of the detector parameters. (author)

  5. Analysis and development of spatial hp-refinement methods for solving the neutron transport equation

    International Nuclear Information System (INIS)

    Fournier, D.

    2011-01-01

    The different neutronic parameters have to be calculated with a higher accuracy in order to design the 4. generation reactor cores. As memory storage and computation time are limited, adaptive methods are a solution to solve the neutron transport equation. The neutronic flux, solution of this equation, depends on the energy, angle and space. The different variables are successively discretized. The energy with a multigroup approach, considering the different quantities to be constant on each group, the angle by a collocation method called SN approximation. Once the energy and angle variable are discretized, a system of spatially-dependent hyperbolic equations has to be solved. Discontinuous finite elements are used to make possible the development of hp-refinement methods. Thus, the accuracy of the solution can be improved by spatial refinement (h-refinement), consisting into subdividing a cell into sub-cells, or by order refinement (p-refinement), by increasing the order of the polynomial basis. In this thesis, the properties of this methods are analyzed showing the importance of the regularity of the solution to choose the type of refinement. Thus, two error estimators are used to lead the refinement process. Whereas the first one requires high regularity hypothesis (analytical solution), the second one supposes only the minimal hypothesis required for the solution to exist. The comparison of both estimators is done on benchmarks where the analytic solution is known by the method of manufactured solutions. Thus, the behaviour of the solution as a regard of the regularity can be studied. It leads to a hp-refinement method using the two estimators. Then, a comparison is done with other existing methods on simplified but also realistic benchmarks coming from nuclear cores. These adaptive methods considerably reduces the computational cost and memory footprint. To further improve these two points, an approach with energy-dependent meshes is proposed. Actually, as the

  6. Haplotype association between haptoglobin (Hp2 and Hp promoter SNP (A-61C may explain previous controversy of haptoglobin and malaria protection.

    Directory of Open Access Journals (Sweden)

    Sharon E Cox

    2007-04-01

    Full Text Available Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded by the co-dominant alleles Hp1 and Hp2, have been variously associated with several infectious diseases, including malaria susceptibility.Risk of a clinical malarial episode over the course of a malarial transmission season was assessed using active surveillance in a cohort of Gambian children aged 10-72 months. We report for the first time that the major haplotype for the A-61C mutant allele in the promoter of haptoglobin (Hp-an acute phase protein that clears haemoglobin released from haemolysis of red cells-is associated with protection from malarial infection in older children, (children aged >or=36 months, >500 parasites/ul and temperature >37.5 degrees C; OR = 0.42; [95% CI 0.24-0.73] p = 0.002 (lr test for interaction, or=36 months, p = 0.014. Protection was also observed using two other definitions, including temperature >37.5 degrees C, dipstick positive, plus clinical judgement of malaria blinded to dipstick result (all ages, OR = 0.48, [95% CI 0.30-0.78] p = 0.003; >or=36 months, OR = 0.31, [95% CI 0.15-0.62] p = 0.001. A similar level of protection was observed for the known protective genetic variant, sickle cell trait (HbAS.We propose that previous conflicting results between Hp phenotypes/genotypes and malaria susceptibility may be explained by differing prevalence of the A-61C SNP in the populations studied, which we found to be highly associated with the Hp2 allele. We report the -61C allele to be associated with decreased Hp protein levels (independent of Hp phenotype, confirming in vitro studies. Decreased Hp expression may lead to increased oxidant stress and increased red cell turnover, and facilitate the development of acquired immunity, similar to

  7. A phantom for assessing the personal dose equivalent, HP(10)

    International Nuclear Information System (INIS)

    Santoro, C.; Filho, J.A

    2013-01-01

    Characteristics of a phantom designed to evaluate the personal dose equivalent, H P (10), and appropriate for photographic dosimetry are presented. It is called HP(10) phantom due to cavities constructed to insert dosimetric films at a depth of 10 mm. The H P (10) phantom is irradiated with ionizing radiation energy, E, from 45 to 1250 keV, with doses ranging from 0.2 to 50 mSv. It is positioned in the direction α = 0 °, and the radiation field focusing perpendicular to its front surface. So, are established calibration curves of dosimeters in the position conventionally true and quantities H P (10). It made a comparison between the responses obtained with the H P (10) phantom and responses obtained when using the calibration procedure recommended by ISO dosimeters. The ISO recommends getting the air kerma, Ka, for photons at test point of the radiation field by an ionization chamber. And through conversion coefficients, h pK (10; E, α), becomes the air kerma for H P (10). The ISO 4037-3 recommendation has been studied by researchers to ensure that the low energy spectral differences occur in radiation fields which are generated by various X-ray equipment, and induce changes in the percentages of conversion coefficients on the order of 10% to 90% . On the basis of the recommendations ISO, this article develops phantom able to assess the dose to the influence of scattering and absorption of radiation, its implications with respect to dosimetry, providing improvement in the assessment of doses. (author)

  8. Celiac disease and Hp infection association in Iran Enfermedades celiacas e infección por Hp en Irán

    Directory of Open Access Journals (Sweden)

    M. Rostami-Nejad

    2009-12-01

    Full Text Available Background: we assessed the prevalence, the related symptoms, and the endoscopic and histologic gastric features of celiac disease (CD in patients with Helicobacter pylori (Hp. Methods: 450 dyspeptic patients were studied. Biopsies of gastric antrum and duodenum, CD serology, and total IgA were obtained. Histological findings were scored with the Marsh-Rostami criteria. Results: 411 (91.3% patients were Hp positive. Duodenal histology was normal in 385 (85.6% patients, 124 (27.5% had duodenitis and 28 (6.2% showed duodenal abnormalities (Marsh I-IIIc. Twenty three/28 (82.1% patients with malabsorption pattern were also Hp positive. Serological analysis: 12 of 31 (38.7% positive patients had abnormal histology (Marsh I,-IIIc. Nine out 450 patients were IgA deficient; none of them was serologically positive for CD. Conclusion: although a high prevalence of Hp infection was found in this study, the relationship between Hp infection and CD was similar to that reported in other geographic areas.

  9. General requirements to implement the personal dose equivalent Hp(10) in Brazil

    International Nuclear Information System (INIS)

    Lopes, Amanda Gomes; Silva, Francisco Cesar Augusto da

    2017-01-01

    To update the dosimetry quantity with the international community, Brazil is changing the Individual Dose Hx to the Personal Dose Equivalent Hp(10). A bibliographical survey on the technical and administrative requirements of nine countries that use Hp(10) was carried out to obtain the most relevant ones. All of them follow IEC and ISO guidelines for technical requirements, while administrative requirements change from country to country. Based on countries experiences, this paper presents a list of important general requirements to implement Hp(10) and to prepare the Brazilian requirements according to the international scientific community. (author)

  10. General requirements to implement the personal dose equivalent Hp(10) in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, Amanda Gomes; Silva, Francisco Cesar Augusto da, E-mail: amandagl@bolsista.ird.gov.br [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2017-07-01

    To update the dosimetry quantity with the international community, Brazil is changing the Individual Dose Hx to the Personal Dose Equivalent Hp(10). A bibliographical survey on the technical and administrative requirements of nine countries that use Hp(10) was carried out to obtain the most relevant ones. All of them follow IEC and ISO guidelines for technical requirements, while administrative requirements change from country to country. Based on countries experiences, this paper presents a list of important general requirements to implement Hp(10) and to prepare the Brazilian requirements according to the international scientific community. (author)

  11. Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis.

    Science.gov (United States)

    Baril, Stefanie A; Koenig, Amber L; Krone, Mackenzie W; Albanese, Katherine I; He, Cyndi Qixin; Lee, Ga Young; Houk, Kendall N; Waters, Marcey L; Brustad, Eric M

    2017-12-06

    Trimethyllysine (Kme3) reader proteins are targets for inhibition due to their role in mediating gene expression. Although all such reader proteins bind Kme3 in an aromatic cage, the driving force for binding may differ; some readers exhibit evidence for cation-π interactions whereas others do not. We report a general unnatural amino acid mutagenesis approach to quantify the contribution of individual tyrosines to cation binding using the HP1 chromodomain as a model system. We demonstrate that two tyrosines (Y24 and Y48) bind to a Kme3-histone tail peptide via cation-π interactions, but linear free energy trends suggest they do not contribute equally to binding. X-ray structures and computational analysis suggest that the distance and degree of contact between Tyr residues and Kme3 plays an important role in tuning cation-π-mediated Kme3 recognition. Although cation-π interactions have been studied in a number of proteins, this work is the first to utilize direct binding assays, X-ray crystallography, and modeling, to pinpoint factors that influence the magnitude of the individual cation-π interactions.

  12. The HP 9825 A program for the determination of an isotope half-life

    International Nuclear Information System (INIS)

    Jujuratisbela, Uju.

    1980-01-01

    Determination of half life of gold 198, indium 116, manganese 56, copper 64 are presented, using least squares method in HP 9825 A. This method is more accurate and needs less time than graphic method. (author tr.)

  13. Figure 1. Prediction of ScHP1 transmembrane domains I to XIV. (http ...

    Indian Academy of Sciences (India)

    Figure 2. Comparison of the ScHP1 amino acid sequence with H. +. -PPase from other species. The conserved domains GGG,. DVGADLVGKVE, DNVGDNVGD, EYYT and GNTTAA were found in the sequence alignment (shown in red boxes).

  14. The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori

    LENUS (Irish Health Repository)

    Douillard, Francois P

    2010-04-08

    Abstract Background Helicobacter pylori is the causative agent for gastritis, and peptic and duodenal ulcers. The bacterium displays 5-6 polar sheathed flagella that are essential for colonisation and persistence in the gastric mucosa. The biochemistry and genetics of flagellar biogenesis in H. pylori has not been fully elucidated. Bioinformatics analysis suggested that the gene HP0256, annotated as hypothetical, was a FliJ homologue. In Salmonella, FliJ is a chaperone escort protein for FlgN and FliT, two proteins that themselves display chaperone activity for components of the hook, the rod and the filament. Results Ablation of the HP0256 gene in H. pylori significantly reduced motility. However, flagellin and hook protein synthesis was not affected in the HP0256 mutant. Transmission electron transmission microscopy revealed that the HP0256 mutant cells displayed a normal flagellum configuration, suggesting that HP0256 was not essential for assembly and polar localisation of the flagella in the cell. Interestingly, whole genome microarrays of an HP0256 mutant revealed transcriptional changes in a number of genes associated with the flagellar regulon and the cell envelope, such as outer membrane proteins and adhesins. Consistent with the array data, lack of the HP0256 gene significantly reduced adhesion and the inflammatory response in host cells. Conclusions We conclude that HP0256 is not a functional counterpart of FliJ in H. pylori. However, it is required for full motility and it is involved, possibly indirectly, in expression of outer membrane proteins and adhesins involved in pathogenesis and adhesion.

  15. Informative gene selection using Adaptive Analytic Hierarchy Process (A2HP

    Directory of Open Access Journals (Sweden)

    Abhishek Bhola

    2017-12-01

    Full Text Available Gene expression dataset derived from microarray experiments are marked by large number of genes, which contains the gene expression values at different sample conditions/time-points. Selection of informative genes from these large datasets is an issue of major concern for various researchers and biologists. In this study, we propose a gene selection and dimensionality reduction method called Adaptive Analytic Hierarchy Process (A2HP. Traditional analytic hierarchy process is a multiple-criteria based decision analysis method whose result depends upon the expert knowledge or decision makers. It is mainly used to solve the decision problems in different fields. On the other hand, A2HP is a fused method that combines the outcomes of five individual gene selection ranking methods t-test, chi-square variance test, z-test, wilcoxon test and signal-to-noise ratio (SNR. At first, the preprocessing of gene expression dataset is done and then the reduced number of genes obtained, will be fed as input for A2HP. A2HP utilizes both quantitative and qualitative factors to select the informative genes. Results demonstrate that A2HP selects efficient number of genes as compared to the individual gene selection methods. The percentage of deduction in number of genes and time complexity are taken as the performance measure for the proposed method. And it is shown that A2HP outperforms individual gene selection methods.

  16. COMPUTING

    CERN Multimedia

    M. Kasemann

    Overview In autumn the main focus was to process and handle CRAFT data and to perform the Summer08 MC production. The operational aspects were well covered by regular Computing Shifts, experts on duty and Computing Run Coordination. At the Computing Resource Board (CRB) in October a model to account for service work at Tier 2s was approved. The computing resources for 2009 were reviewed for presentation at the C-RRB. The quarterly resource monitoring is continuing. Facilities/Infrastructure operations Operations during CRAFT data taking ran fine. This proved to be a very valuable experience for T0 workflows and operations. The transfers of custodial data to most T1s went smoothly. A first round of reprocessing started at the Tier-1 centers end of November; it will take about two weeks. The Computing Shifts procedure was tested full scale during this period and proved to be very efficient: 30 Computing Shifts Persons (CSP) and 10 Computing Resources Coordinators (CRC). The shift program for the shut down w...

  17. COMPUTING

    CERN Multimedia

    I. Fisk

    2011-01-01

    Introduction CMS distributed computing system performed well during the 2011 start-up. The events in 2011 have more pile-up and are more complex than last year; this results in longer reconstruction times and harder events to simulate. Significant increases in computing capacity were delivered in April for all computing tiers, and the utilisation and load is close to the planning predictions. All computing centre tiers performed their expected functionalities. Heavy-Ion Programme The CMS Heavy-Ion Programme had a very strong showing at the Quark Matter conference. A large number of analyses were shown. The dedicated heavy-ion reconstruction facility at the Vanderbilt Tier-2 is still involved in some commissioning activities, but is available for processing and analysis. Facilities and Infrastructure Operations Facility and Infrastructure operations have been active with operations and several important deployment tasks. Facilities participated in the testing and deployment of WMAgent and WorkQueue+Request...

  18. COMPUTING

    CERN Multimedia

    P. McBride

    The Computing Project is preparing for a busy year where the primary emphasis of the project moves towards steady operations. Following the very successful completion of Computing Software and Analysis challenge, CSA06, last fall, we have reorganized and established four groups in computing area: Commissioning, User Support, Facility/Infrastructure Operations and Data Operations. These groups work closely together with groups from the Offline Project in planning for data processing and operations. Monte Carlo production has continued since CSA06, with about 30M events produced each month to be used for HLT studies and physics validation. Monte Carlo production will continue throughout the year in the preparation of large samples for physics and detector studies ramping to 50 M events/month for CSA07. Commissioning of the full CMS computing system is a major goal for 2007. Site monitoring is an important commissioning component and work is ongoing to devise CMS specific tests to be included in Service Availa...

  19. COMPUTING

    CERN Multimedia

    M. Kasemann

    Overview During the past three months activities were focused on data operations, testing and re-enforcing shift and operational procedures for data production and transfer, MC production and on user support. Planning of the computing resources in view of the new LHC calendar in ongoing. Two new task forces were created for supporting the integration work: Site Commissioning, which develops tools helping distributed sites to monitor job and data workflows, and Analysis Support, collecting the user experience and feedback during analysis activities and developing tools to increase efficiency. The development plan for DMWM for 2009/2011 was developed at the beginning of the year, based on the requirements from the Physics, Computing and Offline groups (see Offline section). The Computing management meeting at FermiLab on February 19th and 20th was an excellent opportunity discussing the impact and for addressing issues and solutions to the main challenges facing CMS computing. The lack of manpower is particul...

  20. Single Assignment C: HP^2 programming for heterogeneous concurrent architectures

    NARCIS (Netherlands)

    Scholz, S.-B.; Herhut, S.; Grelck, C.

    2010-01-01

    The range of architectures used in high-performance computing is quickly expanding and at the same time lifetimes of platforms are decreasing. This shift threatens the return on investment for tuning applications to specific architectures and platforms, which until now was the prevailing development

  1. FIST - a suite of X-ray powder crystallography programs for use with a HP-65 calculator

    International Nuclear Information System (INIS)

    Ferguson, I.F.; Turek, M.

    1977-12-01

    Programs for X-ray powder crystallography are defined for use with a Hewlett Packard HP-65 (programmable) pocket calculator. These include the prediction of all Bragg reflections for defined P-, F-, I-cubic, tetragonal, hexagonal and orthorhombic cells; the calculation of the position of a specific Bragg reflection from defined unit cells with all symmetries except triclinic; interconversion of theta, 2theta, sin 2 theta and d, as well as the calculation of the Nelson-Riley function; the computation of crystal densities; the interconversion of rhombohedral and hexagonal unit cells, lsub(c) determinations for graphite, the calculation of a and c for boron carbide; and Miller index transformations between various unit cells. (author)

  2. COMPUTING

    CERN Multimedia

    I. Fisk

    2013-01-01

    Computing activity had ramped down after the completion of the reprocessing of the 2012 data and parked data, but is increasing with new simulation samples for analysis and upgrade studies. Much of the Computing effort is currently involved in activities to improve the computing system in preparation for 2015. Operations Office Since the beginning of 2013, the Computing Operations team successfully re-processed the 2012 data in record time, not only by using opportunistic resources like the San Diego Supercomputer Center which was accessible, to re-process the primary datasets HTMHT and MultiJet in Run2012D much earlier than planned. The Heavy-Ion data-taking period was successfully concluded in February collecting almost 500 T. Figure 3: Number of events per month (data) In LS1, our emphasis is to increase efficiency and flexibility of the infrastructure and operation. Computing Operations is working on separating disk and tape at the Tier-1 sites and the full implementation of the xrootd federation ...

  3. Helicobacter pylori stool antigen test (HpSA) for the diagnosis of gastric infection

    International Nuclear Information System (INIS)

    Faruqui, A.N.; Majid, U.; Ahmed, L.; Khalil, M.; Hussan, M.U.

    2007-01-01

    To determine the accuracy of Helicobacter pylori Stool Antigen test (HpSA), compared with endoscopic histopathology for the diagnosis of gastric Helicobecter pylori infection. A total of 50 patients underwent endoscopy for gastric antral mucosal tissue biopsy for histopathology of H.pylori and advised for HpSA. Patient's information including age, gender, past history, presenting signs and symptoms, results of HpSA and histopathology were recorded. Sensitivity analysis was performed to calculate sensitivity, specificity, and predictive values of HpSA. Among 50 patients, 48% males and 52% females (M: F 1: 1.08), a total of 27 (54%) were true positive while 20 (40%) were true negative. Two patients were false negative and only one was false positive. Sensitivity of HpSA was, therefore, 93.1%, specificity 95% and positive and negative predictive values were 96.42% and 90.9% respectively. Helicobacter pylori stool antigen was an accurate and reliable test for the diagnosis of gastric H. pylori infection. (author)

  4. COMPUTING

    CERN Multimedia

    I. Fisk

    2010-01-01

    Introduction It has been a very active quarter in Computing with interesting progress in all areas. The activity level at the computing facilities, driven by both organised processing from data operations and user analysis, has been steadily increasing. The large-scale production of simulated events that has been progressing throughout the fall is wrapping-up and reprocessing with pile-up will continue. A large reprocessing of all the proton-proton data has just been released and another will follow shortly. The number of analysis jobs by users each day, that was already hitting the computing model expectations at the time of ICHEP, is now 33% higher. We are expecting a busy holiday break to ensure samples are ready in time for the winter conferences. Heavy Ion An activity that is still in progress is computing for the heavy-ion program. The heavy-ion events are collected without zero suppression, so the event size is much large at roughly 11 MB per event of RAW. The central collisions are more complex and...

  5. COMPUTING

    CERN Multimedia

    M. Kasemann P. McBride Edited by M-C. Sawley with contributions from: P. Kreuzer D. Bonacorsi S. Belforte F. Wuerthwein L. Bauerdick K. Lassila-Perini M-C. Sawley

    Introduction More than seventy CMS collaborators attended the Computing and Offline Workshop in San Diego, California, April 20-24th to discuss the state of readiness of software and computing for collisions. Focus and priority were given to preparations for data taking and providing room for ample dialog between groups involved in Commissioning, Data Operations, Analysis and MC Production. Throughout the workshop, aspects of software, operating procedures and issues addressing all parts of the computing model were discussed. Plans for the CMS participation in STEP’09, the combined scale testing for all four experiments due in June 2009, were refined. The article in CMS Times by Frank Wuerthwein gave a good recap of the highly collaborative atmosphere of the workshop. Many thanks to UCSD and to the organizers for taking care of this workshop, which resulted in a long list of action items and was definitely a success. A considerable amount of effort and care is invested in the estimate of the comput...

  6. Analysis of gamma spectra with a HP calcultor

    International Nuclear Information System (INIS)

    Rocc, H.C.

    1978-01-01

    Three programs for the analysis of gamma spectra, specially useful for neutron activation analysis, were adapted and tested. The equipment used is a Hewlett-Packard, model 9810-A desk-computer, supplied with punched tape reader, additional memory in magnetic tape and plotter, being the system capacity 111 numerical registers and 2036 programme steps. The first programme allows automatic photopeak detection in spectra up to 4096 channels, obtained with Ge(Li) detectors,generating the corresponding background radiation line. The areas and their standard deviations are calculated and the spectrum and background can be plotted [pt

  7. Spectral/hp element methods: Recent developments, applications, and perspectives

    DEFF Research Database (Denmark)

    Xu, Hui; Cantwell, Chris; Monteserin, Carlos

    2018-01-01

    regularity assumptions an exponential reduction in approximation error between numerical and exact solutions can be achieved. This method has now been applied in many simulation studies of both fundamental and practical engineering flows. This paper briefly describes the formulation of the spectral...... is based upon orthogonal polynomials, such as Legendre or Chebychev polynomials, modified to accommodate a C 0 - continuous expansion. Computationally and theoretically, by increasing the polynomial order p, high-precision solutions and fast convergence can be obtained and, in particular, under certain...

  8. Graphics-Printing Program For The HP Paintjet Printer

    Science.gov (United States)

    Atkins, Victor R.

    1993-01-01

    IMPRINT utility computer program developed to print graphics specified in raster files by use of Hewlett-Packard Paintjet(TM) color printer. Reads bit-mapped images from files on UNIX-based graphics workstation and prints out three different types of images: wire-frame images, solid-color images, and gray-scale images. Wire-frame images are in continuous tone or, in case of low resolution, in random gray scale. In case of color images, IMPRINT also prints by use of default palette of solid colors. Written in C language.

  9. The Grasso 5HP as a heat pump compressor for a dairy industry; De Grasso 5HP als warmtepompcompressor voor melkfabriek

    Energy Technology Data Exchange (ETDEWEB)

    Vermeer, H.; Gerritsen, J.; Unsworth, R. [Gea Grenco, Den Bosch (Netherlands)

    2011-12-15

    GEA Refrigeration has supplied a new cooling system with an additional stage heat pump to the milk factory Robert Wiseman for the pasteurisation of milk. The required condensation temperature of the additional stage heat pump is around 80C. The Grasso 5HP reciprocating compressor has a favorable energy consumption and can be used for this application. The limitation of this compressor, however, sets requirements to the design of the installation. [Dutch] Gea Refrigeration heeft een nieuwe koelinstallatie met extratrapwarmtepomp geleverd aan zuivelbedrijf Robert Wiseman ten behoeve van pasteuriseren van melk. De hiervoor benodigde condensatietemperatuur van de extratrapwarmtepomp bedraagt ongeveer 80C. De Grasso 5HP hogedrukzuigercompressor heeft een gunstig energiegebruik en kan voor deze toepassing ingezet worden. De begrenzing van het toepassingsgebied van deze compressor stelt echter eisen aan het ontwerp van de installatie.

  10. Investigating tumor perfusion and metabolism using multiple hyperpolarized 13C compounds: HP001, pyruvate and urea

    DEFF Research Database (Denmark)

    von Morze, Cornelius; Larson, Peder E.Z.; Hu, Simon

    2012-01-01

    The metabolically inactive hyperpolarized agents HP001 (bis-1,1-(hydroxymethyl)-[1-13C]cyclopropane-d8) and urea enable a new type of perfusion magnetic resonance imaging based on a direct signal source that is background-free. The addition of perfusion information to metabolic information obtained...... (T1=95 s ex vivo, 32 s in vivo at 3 T) using a pulse sequence with balanced steady-state free precession and ramped flip angle over time for efficient utilization of the hyperpolarized magnetization and three-dimensional echo-planar spectroscopic imaging of urea copolarized with [1-13C...... of separate dynamic HP001 imaging and copolarized pyruvate/urea imaging were compared. A strong and significant correlation (R=0.73, P=.02) detected between the urea and HP001 data confirmed the value of copolarizing urea with pyruvate for simultaneous assessment of perfusion and metabolism....

  11. Influence of niobium addition on the high temperature mechanical properties of a centrifugally cast HP alloy

    International Nuclear Information System (INIS)

    Andrade, A.R.; Bolfarini, C.; Ferreira, L.A.M.; Vilar, A.A.A.; Souza Filho, C.D.; Bonazzi, L.H.C.

    2015-01-01

    The influence of niobium addition on the mechanical properties at high temperature of HP alloy has been investigated. Two HP alloys were centrifugally cast with a similar chemical composition differing only in the niobium content. Low strain rate high temperature tensile tests and creep-rupture tests were performed in the range of 900–1100 °C, and the results compared between the alloys. According to the results, the high temperature mechanical behavior of both alloys is controlled by several factors like solid solution, network of eutectic carbides, intradendritic precipitation and dendrite spacing. A significant increase in the mechanical properties for the HP alloy with niobium addition was found within the temperature range of 900–1050 °C. Beyond this temperature the mechanical behavior of both alloys is basically the same

  12. Preliminary assessment of Geant4 HP models and cross section libraries by reactor criticality benchmark calculations

    DEFF Research Database (Denmark)

    Cai, Xiao-Xiao; Llamas-Jansa, Isabel; Mullet, Steven

    2013-01-01

    Geant4 is an open source general purpose simulation toolkit for particle transportation in matter. Since the extension of the thermal scattering model in Geant4.9.5 and the availability of the IAEA HP model cross section libraries, it is now possible to extend the application area of Geant4......, U and O in uranium dioxide, Al metal, Be metal, and Fe metal. The native HP cross section library G4NDL does not include data for elements with atomic number larger than 92. Therefore, transuranic elements, which have impacts for a realistic reactor, can not be simulated by the combination of the HP...... models and the G4NDL library. However, cross sections of those missing isotopes were made available recently through the IAEA project “new evaluated neutron cross section libraries for Geant4”....

  13. Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem.

    Science.gov (United States)

    Guimarães, Bruno Martini; Prati, Carlo; Duarte, Marco Antonio Hungaro; Bramante, Clovis Monteiro; Gandolfi, Maria Giovanna

    2018-04-05

    This study aimed to analyze the following physicochemical properties: radiopacity, final setting time, calcium release, pH change, solubility, water sorption, porosity, surface morphology, and apatite-forming ability of two calcium silicate-based materials. We tested MTA Repair HP and MTA Vitalcem in comparison with conventional MTA, analyzing radiopacity and final setting time. Water absorption, interconnected pores and apparent porosity were measured after 24-h immersion in deionized water at 37°C. Calcium and pH were tested up to 28 d in deionized water. We analyzed data using two-way ANOVA with Student-Newman-Keuls tests (pcalcium release at 28 d (pcalcium phosphate on their surface after 28 d in HBSS. MTA Repair HP and MTA Vitalcem had extended alkalinizing activity and calcium release that favored calcium phosphate nucleation. The presence of the plasticizer in MTA HP might increase its solubility and porosity. The radiopacifier calcium tungstate can be used to replace bismuth oxide.

  14. COMPUTING

    CERN Multimedia

    P. McBride

    It has been a very active year for the computing project with strong contributions from members of the global community. The project has focused on site preparation and Monte Carlo production. The operations group has begun processing data from P5 as part of the global data commissioning. Improvements in transfer rates and site availability have been seen as computing sites across the globe prepare for large scale production and analysis as part of CSA07. Preparations for the upcoming Computing Software and Analysis Challenge CSA07 are progressing. Ian Fisk and Neil Geddes have been appointed as coordinators for the challenge. CSA07 will include production tests of the Tier-0 production system, reprocessing at the Tier-1 sites and Monte Carlo production at the Tier-2 sites. At the same time there will be a large analysis exercise at the Tier-2 centres. Pre-production simulation of the Monte Carlo events for the challenge is beginning. Scale tests of the Tier-0 will begin in mid-July and the challenge it...

  15. COMPUTING

    CERN Multimedia

    M. Kasemann

    Introduction During the past six months, Computing participated in the STEP09 exercise, had a major involvement in the October exercise and has been working with CMS sites on improving open issues relevant for data taking. At the same time operations for MC production, real data reconstruction and re-reconstructions and data transfers at large scales were performed. STEP09 was successfully conducted in June as a joint exercise with ATLAS and the other experiments. It gave good indication about the readiness of the WLCG infrastructure with the two major LHC experiments stressing the reading, writing and processing of physics data. The October Exercise, in contrast, was conducted as an all-CMS exercise, where Physics, Computing and Offline worked on a common plan to exercise all steps to efficiently access and analyze data. As one of the major results, the CMS Tier-2s demonstrated to be fully capable for performing data analysis. In recent weeks, efforts were devoted to CMS Computing readiness. All th...

  16. COMPUTING

    CERN Multimedia

    I. Fisk

    2011-01-01

    Introduction It has been a very active quarter in Computing with interesting progress in all areas. The activity level at the computing facilities, driven by both organised processing from data operations and user analysis, has been steadily increasing. The large-scale production of simulated events that has been progressing throughout the fall is wrapping-up and reprocessing with pile-up will continue. A large reprocessing of all the proton-proton data has just been released and another will follow shortly. The number of analysis jobs by users each day, that was already hitting the computing model expectations at the time of ICHEP, is now 33% higher. We are expecting a busy holiday break to ensure samples are ready in time for the winter conferences. Heavy Ion The Tier 0 infrastructure was able to repack and promptly reconstruct heavy-ion collision data. Two copies were made of the data at CERN using a large CASTOR disk pool, and the core physics sample was replicated ...

  17. COMPUTING

    CERN Multimedia

    I. Fisk

    2012-01-01

    Introduction Computing continued with a high level of activity over the winter in preparation for conferences and the start of the 2012 run. 2012 brings new challenges with a new energy, more complex events, and the need to make the best use of the available time before the Long Shutdown. We expect to be resource constrained on all tiers of the computing system in 2012 and are working to ensure the high-priority goals of CMS are not impacted. Heavy ions After a successful 2011 heavy-ion run, the programme is moving to analysis. During the run, the CAF resources were well used for prompt analysis. Since then in 2012 on average 200 job slots have been used continuously at Vanderbilt for analysis workflows. Operations Office As of 2012, the Computing Project emphasis has moved from commissioning to operation of the various systems. This is reflected in the new organisation structure where the Facilities and Data Operations tasks have been merged into a common Operations Office, which now covers everything ...

  18. COMPUTING

    CERN Multimedia

    M. Kasemann

    CCRC’08 challenges and CSA08 During the February campaign of the Common Computing readiness challenges (CCRC’08), the CMS computing team had achieved very good results. The link between the detector site and the Tier0 was tested by gradually increasing the number of parallel transfer streams well beyond the target. Tests covered the global robustness at the Tier0, processing a massive number of very large files and with a high writing speed to tapes.  Other tests covered the links between the different Tiers of the distributed infrastructure and the pre-staging and reprocessing capacity of the Tier1’s: response time, data transfer rate and success rate for Tape to Buffer staging of files kept exclusively on Tape were measured. In all cases, coordination with the sites was efficient and no serious problem was found. These successful preparations prepared the ground for the second phase of the CCRC’08 campaign, in May. The Computing Software and Analysis challen...

  19. COMPUTING

    CERN Multimedia

    I. Fisk

    2010-01-01

    Introduction The first data taking period of November produced a first scientific paper, and this is a very satisfactory step for Computing. It also gave the invaluable opportunity to learn and debrief from this first, intense period, and make the necessary adaptations. The alarm procedures between different groups (DAQ, Physics, T0 processing, Alignment/calibration, T1 and T2 communications) have been reinforced. A major effort has also been invested into remodeling and optimizing operator tasks in all activities in Computing, in parallel with the recruitment of new Cat A operators. The teams are being completed and by mid year the new tasks will have been assigned. CRB (Computing Resource Board) The Board met twice since last CMS week. In December it reviewed the experience of the November data-taking period and could measure the positive improvements made for the site readiness. It also reviewed the policy under which Tier-2 are associated with Physics Groups. Such associations are decided twice per ye...

  20. COMPUTING

    CERN Multimedia

    M. Kasemann

    Introduction More than seventy CMS collaborators attended the Computing and Offline Workshop in San Diego, California, April 20-24th to discuss the state of readiness of software and computing for collisions. Focus and priority were given to preparations for data taking and providing room for ample dialog between groups involved in Commissioning, Data Operations, Analysis and MC Production. Throughout the workshop, aspects of software, operating procedures and issues addressing all parts of the computing model were discussed. Plans for the CMS participation in STEP’09, the combined scale testing for all four experiments due in June 2009, were refined. The article in CMS Times by Frank Wuerthwein gave a good recap of the highly collaborative atmosphere of the workshop. Many thanks to UCSD and to the organizers for taking care of this workshop, which resulted in a long list of action items and was definitely a success. A considerable amount of effort and care is invested in the estimate of the co...

  1. HP-67 calculator programs for thermodynamic data and phase diagram calculations

    International Nuclear Information System (INIS)

    Brewer, L.

    1978-01-01

    This report is a supplement to a tabulation of the thermodynamic and phase data for the 100 binary systems of Mo with the elements from H to Lr. The calculations of thermodynamic data and phase equilibria were carried out from 5000 0 K to low temperatures. This report presents the methods of calculation used. The thermodynamics involved is rather straightforward and the reader is referred to any advanced thermodynamic text. The calculations were largely carried out using an HP-65 programmable calculator. In this report, those programs are reformulated for use with the HP-67 calculator; great reduction in the number of programs required to carry out the calculation results

  2. COMPUTING

    CERN Multimedia

    2010-01-01

    Introduction Just two months after the “LHC First Physics” event of 30th March, the analysis of the O(200) million 7 TeV collision events in CMS accumulated during the first 60 days is well under way. The consistency of the CMS computing model has been confirmed during these first weeks of data taking. This model is based on a hierarchy of use-cases deployed between the different tiers and, in particular, the distribution of RECO data to T1s, who then serve data on request to T2s, along a topology known as “fat tree”. Indeed, during this period this model was further extended by almost full “mesh” commissioning, meaning that RECO data were shipped to T2s whenever possible, enabling additional physics analyses compared with the “fat tree” model. Computing activities at the CMS Analysis Facility (CAF) have been marked by a good time response for a load almost evenly shared between ALCA (Alignment and Calibration tasks - highest p...

  3. COMPUTING

    CERN Multimedia

    Contributions from I. Fisk

    2012-01-01

    Introduction The start of the 2012 run has been busy for Computing. We have reconstructed, archived, and served a larger sample of new data than in 2011, and we are in the process of producing an even larger new sample of simulations at 8 TeV. The running conditions and system performance are largely what was anticipated in the plan, thanks to the hard work and preparation of many people. Heavy ions Heavy Ions has been actively analysing data and preparing for conferences.  Operations Office Figure 6: Transfers from all sites in the last 90 days For ICHEP and the Upgrade efforts, we needed to produce and process record amounts of MC samples while supporting the very successful data-taking. This was a large burden, especially on the team members. Nevertheless the last three months were very successful and the total output was phenomenal, thanks to our dedicated site admins who keep the sites operational and the computing project members who spend countless hours nursing the...

  4. COMPUTING

    CERN Multimedia

    M. Kasemann

    Introduction A large fraction of the effort was focused during the last period into the preparation and monitoring of the February tests of Common VO Computing Readiness Challenge 08. CCRC08 is being run by the WLCG collaboration in two phases, between the centres and all experiments. The February test is dedicated to functionality tests, while the May challenge will consist of running at all centres and with full workflows. For this first period, a number of functionality checks of the computing power, data repositories and archives as well as network links are planned. This will help assess the reliability of the systems under a variety of loads, and identifying possible bottlenecks. Many tests are scheduled together with other VOs, allowing the full scale stress test. The data rates (writing, accessing and transfer¬ring) are being checked under a variety of loads and operating conditions, as well as the reliability and transfer rates of the links between Tier-0 and Tier-1s. In addition, the capa...

  5. COMPUTING

    CERN Multimedia

    Matthias Kasemann

    Overview The main focus during the summer was to handle data coming from the detector and to perform Monte Carlo production. The lessons learned during the CCRC and CSA08 challenges in May were addressed by dedicated PADA campaigns lead by the Integration team. Big improvements were achieved in the stability and reliability of the CMS Tier1 and Tier2 centres by regular and systematic follow-up of faults and errors with the help of the Savannah bug tracking system. In preparation for data taking the roles of a Computing Run Coordinator and regular computing shifts monitoring the services and infrastructure as well as interfacing to the data operations tasks are being defined. The shift plan until the end of 2008 is being put together. User support worked on documentation and organized several training sessions. The ECoM task force delivered the report on “Use Cases for Start-up of pp Data-Taking” with recommendations and a set of tests to be performed for trigger rates much higher than the ...

  6. COMPUTING

    CERN Multimedia

    P. MacBride

    The Computing Software and Analysis Challenge CSA07 has been the main focus of the Computing Project for the past few months. Activities began over the summer with the preparation of the Monte Carlo data sets for the challenge and tests of the new production system at the Tier-0 at CERN. The pre-challenge Monte Carlo production was done in several steps: physics generation, detector simulation, digitization, conversion to RAW format and the samples were run through the High Level Trigger (HLT). The data was then merged into three "Soups": Chowder (ALPGEN), Stew (Filtered Pythia) and Gumbo (Pythia). The challenge officially started when the first Chowder events were reconstructed on the Tier-0 on October 3rd. The data operations teams were very busy during the the challenge period. The MC production teams continued with signal production and processing while the Tier-0 and Tier-1 teams worked on splitting the Soups into Primary Data Sets (PDS), reconstruction and skimming. The storage sys...

  7. COMPUTING

    CERN Multimedia

    I. Fisk

    2013-01-01

    Computing operation has been lower as the Run 1 samples are completing and smaller samples for upgrades and preparations are ramping up. Much of the computing activity is focusing on preparations for Run 2 and improvements in data access and flexibility of using resources. Operations Office Data processing was slow in the second half of 2013 with only the legacy re-reconstruction pass of 2011 data being processed at the sites.   Figure 1: MC production and processing was more in demand with a peak of over 750 Million GEN-SIM events in a single month.   Figure 2: The transfer system worked reliably and efficiently and transferred on average close to 520 TB per week with peaks at close to 1.2 PB.   Figure 3: The volume of data moved between CMS sites in the last six months   The tape utilisation was a focus for the operation teams with frequent deletion campaigns from deprecated 7 TeV MC GEN-SIM samples to INVALID datasets, which could be cleaned up...

  8. COMPUTING

    CERN Multimedia

    I. Fisk

    2012-01-01

      Introduction Computing activity has been running at a sustained, high rate as we collect data at high luminosity, process simulation, and begin to process the parked data. The system is functional, though a number of improvements are planned during LS1. Many of the changes will impact users, we hope only in positive ways. We are trying to improve the distributed analysis tools as well as the ability to access more data samples more transparently.  Operations Office Figure 2: Number of events per month, for 2012 Since the June CMS Week, Computing Operations teams successfully completed data re-reconstruction passes and finished the CMSSW_53X MC campaign with over three billion events available in AOD format. Recorded data was successfully processed in parallel, exceeding 1.2 billion raw physics events per month for the first time in October 2012 due to the increase in data-parking rate. In parallel, large efforts were dedicated to WMAgent development and integrati...

  9. COMPUTING

    CERN Multimedia

    I. Fisk

    2011-01-01

    Introduction The Computing Team successfully completed the storage, initial processing, and distribution for analysis of proton-proton data in 2011. There are still a variety of activities ongoing to support winter conference activities and preparations for 2012. Heavy ions The heavy-ion run for 2011 started in early November and has already demonstrated good machine performance and success of some of the more advanced workflows planned for 2011. Data collection will continue until early December. Facilities and Infrastructure Operations Operational and deployment support for WMAgent and WorkQueue+Request Manager components, routinely used in production by Data Operations, are provided. The GlideInWMS and components installation are now deployed at CERN, which is added to the GlideInWMS factory placed in the US. There has been new operational collaboration between the CERN team and the UCSD GlideIn factory operators, covering each others time zones by monitoring/debugging pilot jobs sent from the facto...

  10. The next step in coastal numerical models: spectral/hp element methods?

    DEFF Research Database (Denmark)

    Eskilsson, Claes; Engsig-Karup, Allan Peter; Sherwin, Spencer J.

    2005-01-01

    In this paper we outline the application of spectral/hp element methods for modelling nonlinear and dispersive waves. We present one- and two-dimensional test cases for the shallow water equations and Boussinesqtype equations – including highly dispersive Boussinesq-type equations....

  11. [Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer].

    Science.gov (United States)

    Zhang, J; Lu, X L; Zhao, G; Shi, H T; Geng, Y; Zhong, W T; Dong, L

    2018-02-23

    Objective: To explore relationships between the enrichment of ETBF, Fn, Hp in feces, tissues and colorectal cancer. Methods: Feces, lesion tissue and adjacent tissue from 24 patients with colorectal cancer and 31 patients with adenomas were collected, and we collected Feces and tissue of 20 healthy control persons. Then the copy numbers of enterotoxigenic B. fragilis (ETBF), Fusobacterium nucleatum (Fn) and Helicobacter pylori (Hp) were determined by quantitative real-time PCR. Immunohistochemical method was used to examine the expression intensity of EGFR and p53, and the relationships between different expression intensity of EGFR, p53 and the numbers of three bacterias. Results: In the feces, copy numbers of ETBF and Fn were as follous: colorectal cancer group>adenomas group>healthy control group ( P healthy control group ( P healthy control group ( P adenomas group>healthy control group ( P healthy control group ( P healthy control group ( P bacteria in the lesion tissue and the adjacent tissue had no significant difference. This happened both in colorectal cancer group and adenomas group. The different expression intensity of EGFR, p53 and the number of three bacteria showed no obviously statistical correlation( P >0.05). Conclusion: Adenomatous polyp and colorectal cancer patients show high enrichment of ETBF, Fn and Hp in both feces and tissues. ETBF, Fn and Hp probably contribute to the development of adenomatous polyp and colorectal cancer. Trial registration Chinese Clinical Trial Registry, ChiCTR-BOC-17012509.

  12. Helicobacter pylori HP1034 (ylxH) is required for motility

    NARCIS (Netherlands)

    van Amsterdam, Karin; van der Ende, Arie

    2004-01-01

    Background. Helicobacter pylori motility is essential for the colonization and persistence in the human gastric mucosa. So far, more than 50 genes have been described to play a role in flagellar biosynthesis. H. pylori YlxH (HP1034) is annotated as an ATP-binding protein. However, H. pylori YlxH

  13. Genome-wide analysis reveals the extent of EAV-HP integration in domestic chicken.

    Science.gov (United States)

    Wragg, David; Mason, Andrew S; Yu, Le; Kuo, Richard; Lawal, Raman A; Desta, Takele Taye; Mwacharo, Joram M; Cho, Chang-Yeon; Kemp, Steve; Burt, David W; Hanotte, Olivier

    2015-10-14

    EAV-HP is an ancient retrovirus pre-dating Gallus speciation, which continues to circulate in modern chicken populations, and led to the emergence of avian leukosis virus subgroup J causing significant economic losses to the poultry industry. We mapped EAV-HP integration sites in Ethiopian village chickens, a Silkie, Taiwan Country chicken, red junglefowl Gallus gallus and several inbred experimental lines using whole-genome sequence data. An average of 75.22 ± 9.52 integration sites per bird were identified, which collectively group into 279 intervals of which 5 % are common to 90 % of the genomes analysed and are suggestive of pre-domestication integration events. More than a third of intervals are specific to individual genomes, supporting active circulation of EAV-HP in modern chickens. Interval density is correlated with chromosome length (P < 2.31(-6)), and 27 % of intervals are located within 5 kb of a transcript. Functional annotation clustering of genes reveals enrichment for immune-related functions (P < 0.05). Our results illustrate a non-random distribution of EAV-HP in the genome, emphasising the importance it may have played in the adaptation of the species, and provide a platform from which to extend investigations on the co-evolutionary significance of endogenous retroviral genera with their hosts.

  14. Developing Consensus on the CompHP Professional Standards for Health Promotion in Europe

    Science.gov (United States)

    Speller, Viv; Parish, Richard; Davison, Heather; Zilnyk, Anna

    2012-01-01

    Building on the CompHP Core Competencies for health promotion the Professional Standards for Health Promotion have been developed and consulted on across Europe. The standards were formulated to fit within the complexity of professional, occupational and educational standards frameworks in Europe as learning outcome standards with performance…

  15. HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.

    Science.gov (United States)

    Osbourn, Megan; Soares, Dinesh C; Vacca, Francesco; Cohen, E Suzanne; Scott, Ian C; Gregory, William F; Smyth, Danielle J; Toivakka, Matilda; Kemter, Andrea M; le Bihan, Thierry; Wear, Martin; Hoving, Dennis; Filbey, Kara J; Hewitson, James P; Henderson, Holly; Gonzàlez-Cìscar, Andrea; Errington, Claire; Vermeren, Sonja; Astier, Anne L; Wallace, William A; Schwarze, Jürgen; Ivens, Alasdair C; Maizels, Rick M; McSorley, Henry J

    2017-10-17

    Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. Here, we identified H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted complement control protein (CCP) modules. In vivo, recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosinophilic responses to Nippostrongylus brasiliensis, increasing parasite burden. HpARI bound directly to both mouse and human IL-33 (in the cytokine's activated state) and also to nuclear DNA via its N-terminal CCP module pair (CCP1/2), tethering active IL-33 within necrotic cells, preventing its release, and forestalling initiation of type 2 allergic responses. Thus, HpARI employs a novel molecular strategy to suppress type 2 immunity in both infection and allergy. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  16. hp-FEM electromechanical transduction model of ionic polymer metal composites

    Czech Academy of Sciences Publication Activity Database

    Pugal, D.; Šolín, Pavel; Kim, K.; Aabloo, A.

    2014-01-01

    Roč. 260, April (2014), s. 135-148 ISSN 0377-0427 R&D Projects: GA ČR(CZ) GAP102/11/0498 Institutional support: RVO:61388998 Keywords : hp-FEM * Nernst-Planck * Poisson Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.266, year: 2014

  17. An hp-adaptive strategy for the solution of the exact kernel curved wire Pocklington equation

    NARCIS (Netherlands)

    D.J.P. Lahaye (Domenico); P.W. Hemker (Piet)

    2007-01-01

    textabstractIn this paper we introduce an adaptive method for the numerical solution of the Pocklington integro-differential equation with exact kernel for the current induced in a smoothly curved thin wire antenna. The hp-adaptive technique is based on the representation of the discrete solution,

  18. Critical Success Factors in Crafting Strategic Architecture for E-Learning at HP University

    Science.gov (United States)

    Sharma, Kunal; Pandit, Pallvi; Pandit, Parul

    2011-01-01

    Purpose: The purpose of this paper is to outline the critical success factors for crafting a strategic architecture for e-learning at HP University. Design/methodology/approach: A descriptive survey type of research design was used. An empirical study was conducted on students enrolled with the International Centre for Distance and Open Learning…

  19. Space-time adaptive hp-FEM for problems with traveling sharp fronts

    Czech Academy of Sciences Publication Activity Database

    Šolín, Pavel; Korous, L.

    2013-01-01

    Roč. 95, č. 1 (2013), S709-S722 ISSN 0010-485X Institutional support: RVO:61388998 Keywords : adaptive hp-FEM * transient problems * sharp fronts Subject RIV: BA - General Mathematics Impact factor: 1.055, year: 2013

  20. On optimal node and polynomial degree distribution in one-dimensional hp -FEM

    Czech Academy of Sciences Publication Activity Database

    Chleboun, J.; Šolín, Pavel

    2013-01-01

    Roč. 95, č. 1 (2013), s. 75-88 ISSN 1436-5057 R&D Projects: GA ČR GAP105/10/1682 Institutional support: RVO:61388998 Keywords : hp * boundary value problem * optimal mesh Subject RIV: JM - Building Engineering

  1. Susceptibility of the Tomato Mutant High Pigment-2dg (hp-2dg) to Orobanche spp. Infection

    NARCIS (Netherlands)

    Lopez Raez, J.A.; Charnikhova, T.; Mulder, P.P.J.; Kohlen, W.; Bino, R.J.; Levin, I.; Bouwmeester, H.J.

    2008-01-01

    The consumption of natural products with potential health benefits has been continuously growing, and enhanced pigmentation is of major economic importance in fruits and vegetables. The tomato hp-2dg is an important mutant line that has been introgressed into commercial tomato cultivars marketed as

  2. Susceptibility of the tomato mutant high pigment-2dg (hp-2dg) to Orobanche spp. infection.

    Science.gov (United States)

    López-Ráez, Juan Antonio; Charnikhova, Tatsiana; Mulder, Patrick; Kohlen, Wouter; Bino, Raoul; Levin, Ilan; Bouwmeester, Harro

    2008-08-13

    The consumption of natural products with potential health benefits has been continuously growing, and enhanced pigmentation is of major economic importance in fruits and vegetables. The tomato hp-2 ( dg ) is an important mutant line that has been introgressed into commercial tomato cultivars marketed as lycopene rich tomatoes (LRT) because of their enhanced fruit pigmentation, attributed to higher levels of carotenoids, including lycopene. Strigolactones are signaling compounds that mediate host finding in root parasitic plants and are biosynthetically derived from carotenoids. Considering the high carotenoid content of the hp-2 ( dg ) mutant, we studied its susceptibility to the root parasite Orobanche. In a field experiment, the average number of Orobanche aegyptiaca plants growing on hp-2 ( dg ) was surprisingly significantly reduced compared with its isogenic wild-type counterpart. In vitro assays and LC-MS/MS analysis showed that this reduction was associated with a lower production of strigolactones, which apparently renders the high-carotenoid hp-2 ( dg ) mutant less susceptible to Orobanche.

  3. hpGEM -- A software framework for discontinuous Galerkin finite element methods

    NARCIS (Netherlands)

    Pesch, L.; Bell, A.; Sollie, W.E.H.; Ambati, V.R.; Bokhove, Onno; van der Vegt, Jacobus J.W.

    2006-01-01

    hpGEM, a novel framework for the implementation of discontinuous Galerkin finite element methods, is described. We present structures and methods that are common for many (discontinuous) finite element methods and show how we have implemented the components as an object-oriented framework. This

  4. Mechanisms of continental subduction and exhumation of HP and UHP rocks

    NARCIS (Netherlands)

    Burov, Evgene; Francois, Thomas; Yamato, Philippe; Wolf, Sylvie

    We discuss possible scenarios of continental collision, and their relation to mechanisms of exhumation of HP and UHP rocks, inferred from thermo-mechanical numerical models accounting for thermo-rheological complexity of the continental lithosphere. Due to this complexity, mechanisms of continental

  5. The Weak Link HP-41C hand-held calculator program

    Science.gov (United States)

    Ross A. Phillips; Penn A. Peters; Gary D. Falk

    1982-01-01

    The Weak Link hand-held calculator program (HP-41C) quickly analyzes a system for logging production and costs. The production equations model conventional chain saw, skidder, loader, and tandemaxle truck operations in eastern mountain areas. Production of each function of the logging system may be determined so that the system may be balanced for minimum cost. The...

  6. On Adjusting the H-P Filter for the Frequency of Observations

    NARCIS (Netherlands)

    Uhlig, H.F.H.V.S.; Ravn, M.

    1997-01-01

    This paper studies how the HP-Filter should be adjusted, when changing the frequency of observations. The usual choices in the literature are to adjust the smoothing parameter by multiplying it with either the square of the observation frequency ratios or simply with the observation frequency. In

  7. COMPUTING

    CERN Multimedia

    M. Kasemann

    CMS relies on a well functioning, distributed computing infrastructure. The Site Availability Monitoring (SAM) and the Job Robot submission have been very instrumental for site commissioning in order to increase availability of more sites such that they are available to participate in CSA07 and are ready to be used for analysis. The commissioning process has been further developed, including "lessons learned" documentation via the CMS twiki. Recently the visualization, presentation and summarizing of SAM tests for sites has been redesigned, it is now developed by the central ARDA project of WLCG. Work to test the new gLite Workload Management System was performed; a 4 times increase in throughput with respect to LCG Resource Broker is observed. CMS has designed and launched a new-generation traffic load generator called "LoadTest" to commission and to keep exercised all data transfer routes in the CMS PhE-DEx topology. Since mid-February, a transfer volume of about 12 P...

  8. Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites

    Czech Academy of Sciences Publication Activity Database

    Bártová, Eva; Pacherník, J.; Kozubík, Alois; Kozubek, Stanislav

    2007-01-01

    Roč. 127, č. 4 (2007), s. 375-388 ISSN 0948-6143 R&D Projects: GA AV ČR(CZ) 1QS500040508; GA AV ČR(CZ) IAA5004306; GA MŠk(CZ) LC535; GA ČR(CZ) GA204/06/0978; GA ČR(CZ) GP524/03/P171 Institutional research plan: CEZ:AV0Z50040702 Keywords : HP1 proteiny * TIF1beta * chromocentry Subject RIV: BO - Biophysics Impact factor: 2.893, year: 2007

  9. Synthesis gas generation by high pressure partial oxidation (HP POX {sup registered}); Synthesegaserzeugung durch Hochdruck-Partialoxidation (HP POX {sup registered})

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, B.; Seifert, P.; Zeissler, R. [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Energieverfahrenstechnik und Chemieingenieurwesen; Walter, St. [Lurgi AG, Frankfurt/Main (Germany)

    2005-05-01

    The high pressure synthesis gas process HP POX (High Pressure Partial Oxidation) is a thermal conversion process, which converts e.g. natural gas or heavy residue oil with oxygen to fuel or synthesis gas. Innovative burner technologies allow autothermal catalytic or non-catalytic reforming of gaseous feedstock and gasification of liquid feed streams. Hydrogen and carbon monoxide rich synthesis gases with low methane content (particularly suitable as feed gas for methanol synthesis) can be generated. The technology represents a new generation of entrained flow gasification characterized by the new developed equipment and a design pressure of 100 bar. According to the feeds, the HP POX gasification process is the link between the downstream synthesis chemistry (use of gaseous and liquid feeds) and the power plant process (liquid or solid fuels as suspension or slurry). The HP POX development is carried out together with the Lurgi AG at the Institute for Energy Process Engineering and Chemical Engineering (IEC). The 5 MW HP POX test plant built in Freiberg by Lurgi is core of the joint research project, which is supported by the German Federal Ministry of Economics and Labour (BMWA), the Saxon Ministry of Science and the Fine Arts (SMWK), and the mg technologies ag (parent company of Lurgi). The conducted sets of experiments indicate that the unit can be operated in a safe, smooth and stable manner. During this periods of operation, which included nine test campaigns for autothermal reforming (ATR), the maximum pressure for ATR amounted to 70 bar which exceeds the current benchmark in industry for 30 bar. Main objective of R and D work is the development of modelling tools for extreme gasification conditions and different gasification principles of up to 100 bar. These tools are supposed to improve the understanding of the entire gasification process. Their development requires a systematic investigation of the reaction mechanisms and the interactions with the process

  10. HP-multigrid as smoother algorithm for higher order discontinuous Galerkin discretizations of advection dominated flows. Part I. Multilevel Analysis

    NARCIS (Netherlands)

    van der Vegt, Jacobus J.W.; Rhebergen, Sander

    2011-01-01

    The hp-Multigrid as Smoother algorithm (hp-MGS) for the solution of higher order accurate space-(time) discontinuous Galerkin discretizations of advection dominated flows is presented. This algorithm combines p-multigrid with h-multigrid at all p-levels, where the h-multigrid acts as smoother in the

  11. dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.

    Science.gov (United States)

    Chavez, Joselyn; Murillo-Maldonado, Juan Manuel; Bahena, Vanessa; Cruz, Ana Karina; Castañeda-Sortibrán, América; Rodriguez-Arnaiz, Rosario; Zurita, Mario; Valadez-Graham, Viviana

    2017-12-01

    Telomeres are important contributors to genome stability, as they prevent linear chromosome end degradation and contribute to the avoidance of telomeric fusions. An important component of the telomeres is the heterochromatin protein 1a (HP1a). Mutations in Su(var)205, the gene encoding HP1a in Drosophila, result in telomeric fusions, retrotransposon regulation loss and larger telomeres, leading to chromosome instability. Previously, it was found that several proteins physically interact with HP1a, including dXNP and dAdd1 (orthologues to the mammalian ATRX gene). In this study, we found that mutations in the genes encoding the dXNP and dAdd1 proteins affect chromosome stability, causing chromosomal aberrations, including telomeric defects, similar to those observed in Su(var)205 mutants. In somatic cells, we observed that dXNP and dAdd1 participate in the silencing of the telomeric HTT array of retrotransposons, preventing anomalous retrotransposon transcription and integration. Furthermore, the lack of dAdd1 results in the loss of HP1a from the telomeric regions without affecting other chromosomal HP1a binding sites; mutations in dxnp also affected HP1a localization but not at all telomeres, suggesting a specialized role for dAdd1 and dXNP proteins in locating HP1a at the tips of the chromosomes. These results place dAdd1 as an essential regulator of HP1a localization and function in the telomere heterochromatic domain.

  12. A sensitization effect of hematoporphyrin oligomer (HpO) and caffeine for X-ray radiation of skin cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ishiguro, Kazumori; Ueda, Keiichi; Miyoshi, Norio; Nakanishi, Kazuo; Fukuda, Masaru (Fukui Medical School, Matsuoka (Japan))

    1990-05-01

    Human malignant melanoma cells (G-361) were irradiated with X-ray for different irradiation times. The amount of DNA damage was much increased by the treatment of the cells with hematoporphyrin oligomer (HpO) before X-ray irradiation. Furthermore, it was found that the caffeine inhibited effectively the repair of the damaged DNA. Furthermore, HpO was administered before X-ray irradiation of transplantable skin tumor in C3H mice and/or caffeine was to be given the mouse after X-ray irradiation. The growth of the irradiated tumor combined with HpO and/or caffeine was more inhibited, and the necrotic area was more expanded than that of the tumor irradiated with X-ray only. Labeling Index utilizing bromodeoxyuridine (BrdU) in the viable area of the treated tumor decreased when HpO and/or caffeine were administered. The amount of DNA damage more increased in the irradiated tumor cells given HpO than the only irradiated cells. And, the repair of the damaged DNA was more delayed in the irradiated tumor cells combined with HpO and caffeine than those with other treatments. In conclusion, it was considered that HpO might be a radioactive sensitizer and caffeine enhanced the inhibition of the repair of DNA damaged. We hope that the treatment of X-ray radiation combined with HpO and caffeine is useful for clinical treatment of human malignant tumor. (author) 54 refs.

  13. The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.

    Science.gov (United States)

    Leonard, Phoebe H; Grzenda, Adrienne; Mathison, Angela; Morbeck, Dean E; Fredrickson, Jolene R; de Assuncao, Thiago M; Christensen, Trace; Salisbury, Jeffrey; Calvo, Ezequiel; Iovanna, Juan; Coddington, Charles C; Urrutia, Raul; Lomberk, Gwen

    2015-05-29

    HP1γ, a well-known regulator of gene expression, has been recently identified to be a target of Aurora A, a mitotic kinase which is important for both gametogenesis and embryogenesis. The purpose of this study was to define whether the Aurora A-HP1γ pathway supports cell division of gametes and/or early embryos, using western blot, immunofluorescence, immunohistochemistry, electron microscopy, shRNA-based knockdown, site-directed mutagenesis, and Affymetrix-based genome-wide expression profiles. We find that the form of HP1γ phosphorylated by Aurora A, P-Ser83 HP1γ, is a passenger protein, which localizes to the spermatozoa centriole and axoneme. In addition, disruption in this pathway causes centrosomal abnormalities and aberrations in cell division. Expression profiling of male germ cell lines demonstrates that HP1γ phosphorylation is critical for the regulation of mitosis-associated gene expression networks. In female gametes, we observe that P-Ser83-HP1γ is not present in meiotic centrosomes of M2 oocytes, but after syngamy, it becomes detectable during cleavage divisions, coinciding with early embryonic genome activation. These results support the idea that phosphorylation of HP1γ by Aurora A plays a role in the regulation of gene expression and mitotic cell division in cells from the sperm lineage and in early embryos. Combined, this data is relevant to better understanding the function of HP1γ in reproductive biology.

  14. A sensitization effect of hematoporphyrin oligomer (HpO) and caffeine for X-ray radiation of skin cancer

    International Nuclear Information System (INIS)

    Ishiguro, Kazumori; Ueda, Keiichi; Miyoshi, Norio; Nakanishi, Kazuo; Fukuda, Masaru

    1990-01-01

    Human malignant melanoma cells (G-361) were irradiated with X-ray for different irradiation times. The amount of DNA damage was much increased by the treatment of the cells with hematoporphyrin oligomer (HpO) before X-ray irradiation. Furthermore, it was found that the caffeine inhibited effectively the repair of the damaged DNA. Furthermore, HpO was administered before X-ray irradiation of transplantable skin tumor in C3H mice and/or caffeine was to be given the mouse after X-ray irradiation. The growth of the irradiated tumor combined with HpO and/or caffeine was more inhibited, and the necrotic area was more expanded than that of the tumor irradiated with X-ray only. Labeling Index utilizing bromodeoxyuridine (BrdU) in the viable area of the treated tumor decreased when HpO and/or caffeine were administered. The amount of DNA damage more increased in the irradiated tumor cells given HpO than the only irradiated cells. And, the repair of the damaged DNA was more delayed in the irradiated tumor cells combined with HpO and caffeine than those with other treatments. In conclusion, it was considered that HpO might be a radioactive sensitizer and caffeine enhanced the inhibition of the repair of DNA damaged. We hope that the treatment of X-ray radiation combined with HpO and caffeine is useful for clinical treatment of human malignant tumor. (author) 54 refs

  15. Computer program for storage and retrieval of thermal-stability data for explosives

    International Nuclear Information System (INIS)

    Ashcraft, R.W.

    1981-06-01

    A computer program for storage and retrieval of thermal stability data has been written in HP Basic for the HP-9845 system. The data library is stored on a 9885 flexible disk. A program listing and sample outputs are included as appendices

  16. Crystallography and Morphology of MC Carbides in Niobium-Titanium Modified As-Cast HP Alloys

    Science.gov (United States)

    Buchanan, Karl G.; Kral, Milo V.; Bishop, Catherine M.

    2014-07-01

    The microstructures of two as-cast heats of HP alloy stainless steels modified with niobium and titanium were examined with particular attention paid to the interdendritic niobium-titanium-rich carbides formed during solidification of these alloys. Generally, these precipitates obtain a blocky morphology in the as-cast condition. However, the (NbTi)C precipitates may obtain a nodular morphology. To provide further insight to the origin of the two different morphologies obtained by the (NbTi)C precipitates in the HP-NbTi alloy, the microstructure and crystallography of each have been studied in detail using scanning electron microscopy, transmission electron microscopy, various electron diffraction methods (EBSD, SAD, and CBED), and energy-dispersive X-ray spectroscopy.

  17. Weighted curve-fitting program for the HP 67/97 calculator

    International Nuclear Information System (INIS)

    Stockli, M.P.

    1983-01-01

    The HP 67/97 calculator provides in its standard equipment a curve-fit program for linear, logarithmic, exponential and power functions that is quite useful and popular. However, in more sophisticated applications, proper weights for data are often essential. For this purpose a program package was created which is very similar to the standard curve-fit program but which includes the weights of the data for proper statistical analysis. This allows accurate calculation of the uncertainties of the fitted curve parameters as well as the uncertainties of interpolations or extrapolations, or optionally the uncertainties can be normalized with chi-square. The program is very versatile and allows one to perform quite difficult data analysis in a convenient way with the pocket calculator HP 67/97

  18. A new crystal lattice structure of Helicobacter pylori neutrophil-activating protein (HP-NAP)

    International Nuclear Information System (INIS)

    Tsuruta, Osamu; Yokoyama, Hideshi; Fujii, Satoshi

    2012-01-01

    A new crystal lattice structure of H. pylori neutrophil-activating protein has been determined. Iron loading causes a series of conformational changes at the ferroxidase centre. A new crystal lattice structure of Helicobacter pylori neutrophil-activating protein (HP-NAP) has been determined in two forms: the native state (Apo) at 2.20 Å resolution and an iron-loaded form (Fe-load) at 2.50 Å resolution. The highly solvated packing of the dodecameric shell is suitable for crystallographic study of the metal ion-uptake pathway. Like other bacterioferritins, HP-NAP forms a spherical dodecamer with 23 symmetry including two kinds of channels. Iron loading causes a series of conformational changes of amino-acid residues (Trp26, Asp52 and Glu56) at the ferroxidase centre

  19. Surface adsorption of lattice HP proteins: Thermodynamics and structural transitions using Wang-Landau sampling

    International Nuclear Information System (INIS)

    Li Yingwai; Landau, David P; Wüst, Thomas

    2012-01-01

    Wang-Landau sampling has been applied to investigate the thermodynamics and structural properties of a lattice hydrophobic-polar heteropolymer (the HP protein model) interacting with an attractive substrate. For simplicity, we consider a short HP sequence consisting of only 36 monomers interacting with a substrate which attracts all monomers in the sequence. The conformational “phase transitions” have been identified by a canonical analysis of the specific heat and suitable structural observables. Three major “transitions”, namely, adsorption, hydrophobic core formation and “flattening” of adsorbed structures, are observed. Depending on the surface attractive strength relative to the intra-protein attraction among the H monomers, these processes take place in different sequences upon cooling.

  20. Arbitrary-Level Hanging Nodes and Automatic Adaptivity in the hp-FEM

    Czech Academy of Sciences Publication Activity Database

    Šolín, Pavel; Červený, Jakub; Doležel, Ivo

    2008-01-01

    Roč. 77, č. 1 (2008), s. 117-132 ISSN 0378-4754 R&D Projects: GA ČR(CZ) GA102/07/0496; GA ČR GA102/05/0629; GA AV ČR IAA100760702 Institutional research plan: CEZ:AV0Z20570509 Keywords : constrained approximation * hanging nodes * hp-FEM Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.930, year: 2008

  1. HpBase: A genome database of a sea urchin, Hemicentrotus pulcherrimus.

    Science.gov (United States)

    Kinjo, Sonoko; Kiyomoto, Masato; Yamamoto, Takashi; Ikeo, Kazuho; Yaguchi, Shunsuke

    2018-04-01

    To understand the mystery of life, it is important to accumulate genomic information for various organisms because the whole genome encodes the commands for all the genes. Since the genome of Strongylocentrotus purpratus was sequenced in 2006 as the first sequenced genome in echinoderms, the genomic resources of other North American sea urchins have gradually been accumulated, but no sea urchin genomes are available in other areas, where many scientists have used the local species and reported important results. In this manuscript, we report a draft genome of the sea urchin Hemincentrotus pulcherrimus because this species has a long history as the target of developmental and cell biology in East Asia. The genome of H. pulcherrimus was assembled into 16,251 scaffold sequences with an N50 length of 143 kbp, and approximately 25,000 genes were identified in the genome. The size of the genome and the sequencing coverage were estimated to be approximately 800 Mbp and 100×, respectively. To provide these data and information of annotation, we constructed a database, HpBase (http://cell-innovation.nig.ac.jp/Hpul/). In HpBase, gene searches, genome browsing, and blast searches are available. In addition, HpBase includes the "recipes" for experiments from each lab using H. pulcherrimus. These recipes will continue to be updated according to the circumstances of individual scientists and can be powerful tools for experimental biologists and for the community. HpBase is a suitable dataset for evolutionary, developmental, and cell biologists to compare H. pulcherrimus genomic information with that of other species and to isolate gene information. © 2018 Japanese Society of Developmental Biologists.

  2. Discrete maximum principle for Poisson equation with mixed boundary conditions solved by hp-FEM

    Czech Academy of Sciences Publication Activity Database

    Vejchodský, Tomáš; Šolín, P.

    2009-01-01

    Roč. 1, č. 2 (2009), s. 201-214 ISSN 2070-0733 R&D Projects: GA AV ČR IAA100760702; GA ČR(CZ) GA102/07/0496; GA ČR GA102/05/0629 Institutional research plan: CEZ:AV0Z10190503 Keywords : discrete maximum principle * hp-FEM * Poisson equation * mixed boundary conditions Subject RIV: BA - General Mathematics

  3. Discrete conservation of nonnegativity for elliptic problems solved by the hp-FEM

    Czech Academy of Sciences Publication Activity Database

    Šolín, P.; Vejchodský, Tomáš; Araiza, R.

    2007-01-01

    Roč. 76, 1-3 (2007), s. 205-210 ISSN 0378-4754 R&D Projects: GA ČR GP201/04/P021 Institutional research plan: CEZ:AV0Z10190503 Keywords : discrete nonnegativity conservation * discrete Green's function * elliptic problems * hp-FEM * higher-order finite element methods * Poisson equation * numerical experimetns Subject RIV: BA - General Mathematics Impact factor: 0.738, year: 2007

  4. Investigation of the $^{8}$Li($^{2}$H,p)$^{9}$Li Reaction at REX-ISOLDE

    CERN Multimedia

    2002-01-01

    We propose to investigate the $^{8}$Li($^{2}$H,p )$^{9}$Li reaction at REX-ISOLDE. The main aim is to test a recently found discrepancy in extracted spectroscopic factors for this reaction. As a byproduct we will obtain improved data relevant for predictions of the $^{8}$Li(n,$\\gamma$)$^{9}$Li rate in inhomogeneous nucleosynthesis. For the full experiment including beam tuning and background measurements we ask for 13 shifts.

  5. Substructuring preconditioners for an h-p domain decomposition method with interior penalty mortaring

    KAUST Repository

    Antonietti, P. F.; Ayuso Dios, Blanca; Bertoluzza, S.; Pennacchio, M.

    2014-01-01

    We propose and study an iterative substructuring method for an h-p Nitsche-type discretization, following the original approach introduced in Bramble et al. Math. Comp. 47(175):103–134, (1986) for conforming methods. We prove quasi-optimality with respect to the mesh size and the polynomial degree for the proposed preconditioner. Numerical experiments assess the performance of the preconditioner and verify the theory. © 2014, Springer-Verlag Italia.

  6. Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters.

    Science.gov (United States)

    Manyam, Bala V; Dhanasekaran, Muralikrishnan; Hare, Theodore A

    2004-02-01

    HP-200, which contains Mucuna pruriens endocarp, has been shown to be effective in the treatment of Parkinson's disease. Mucuna pruriens endocarp has also been shown to be more effective compared to synthetic levodopa in an animal model of Parkinson's disease. The present study was designed to elucidate the long-term effect of Mucuna pruriens endocarp in HP-200 on monoaminergic neurotransmitters and its metabolite in various regions of the rat brain. HP-200 at a dose of 2.5, 5.0 or 10.0 g/kg/day was mixed with rat chow and fed daily ad lib to Sprague-Dawley rats (n = 6 for each group) for 52 weeks. Controls (n = 6) received no drug. Random assignment was made for doses and control. The rats were sacrificed at the end of 52 weeks and the neurotransmitters were analyzed in the cortex, hippocampus, substantia nigra and striatum. Oral administration of Mucuna pruriens endocarp in the form of HP-200 had a significant effect on dopamine content in the cortex with no significant effect on levodopa, norepinephrine or dopamine, serotonin, and their metabolites- HVA, DOPAC and 5-HIAA in the nigrostriatal tract. The failure of Mucuna pruriens endocarp to significantly affect dopamine metabolism in the striatonigral tract along with its ability to improve Parkinsonian symptoms in the 6-hydorxydopamine animal model and humans may suggest that its antiparkinson effect may be due to components other than levodopa or that it has an levodopa enhancing effect. Copyright 2004 John Wiley & Sons, Ltd. Copyright 2004 John Wiley & Sons, Ltd.

  7. Substructuring preconditioners for an h-p domain decomposition method with interior penalty mortaring

    KAUST Repository

    Antonietti, P. F.

    2014-05-13

    We propose and study an iterative substructuring method for an h-p Nitsche-type discretization, following the original approach introduced in Bramble et al. Math. Comp. 47(175):103–134, (1986) for conforming methods. We prove quasi-optimality with respect to the mesh size and the polynomial degree for the proposed preconditioner. Numerical experiments assess the performance of the preconditioner and verify the theory. © 2014, Springer-Verlag Italia.

  8. An h-p Taylor-Galerkin finite element method for compressible Euler equations

    Science.gov (United States)

    Demkowicz, L.; Oden, J. T.; Rachowicz, W.; Hardy, O.

    1991-01-01

    An extension of the familiar Taylor-Galerkin method to arbitrary h-p spatial approximations is proposed. Boundary conditions are analyzed, and a linear stability result for arbitrary meshes is given, showing the unconditional stability for the parameter of implicitness alpha not less than 0.5. The wedge and blunt body problems are solved with both linear, quadratic, and cubic elements and h-adaptivity, showing the feasibility of higher orders of approximation for problems with shocks.

  9. Modular hp-FEM system HERMES and its application to Maxwell´s equations

    Czech Academy of Sciences Publication Activity Database

    Vejchodský, Tomáš; Šolín, P.; Zítka, M.

    2007-01-01

    Roč. 76, č. 2 (2007), s. 223-228 ISSN 0378-4754. [MODELLING 2005. Plzeň, 04.06.2005-08.06.2005] R&D Projects: GA ČR GP201/04/P021 Institutional research plan: CEZ:AV0Z10190503 Keywords : hp-FEM * time-harmonic Maxwell´s equations * hierarchic higher-order edge elements Subject RIV: BA - General Mathematics Impact factor: 0.738, year: 2007

  10. Quasielastic 3Hp scattering at 2.5 GeV/c triton momentum

    International Nuclear Information System (INIS)

    Blinov, A.V.; Chuvilo, I.V.; Ergakov, V.A.

    1982-01-01

    The differential cross sections of the quasielastic 3 Hp-scattering at a 2.5 GeV/c tritium momentum (Tsub(p)=318 MeV) have been measured using the ITEP 80 cm hydrogen buble chamber. The experimental results are compared with the predictions of the Glauber-Sitenke multiple scattering theory combined with the the completeness condition for the excited nucleus wave functions. The validity of the Glauber sum rule for the differential cross sections is investigated

  11. Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box

    International Nuclear Information System (INIS)

    Moriyama, Tetsuji; Sangel, Percival; Yamaguchi, Hiroki; Obuse, Chikashi; Miyamoto, Yoichi; Oka, Masahiro; Yoneda, Yoshihiro

    2015-01-01

    Tripartite motif-containing 28 (TRIM28) is a transcription regulator, which forms a repressor complex containing heterochromatin protein 1 (HP1). Here, we report identification of a nuclear localization signal (NLS) within the 462-494 amino acid region of TRIM28 that overlaps with its HP1 binding site, HP1 box. GST-pulldown experiments revealed the interaction of the arginine-rich TRIM28 NLS with various importin α subtypes (α1, α2 and α4). In vitro transport assay demonstrated that nuclear localization of GFP-TRIM28 NLS is mediated by importin αs, in conjunction with importin β1 and Ran. Further, we demonstrated that HP1 and importin αs compete for binding to TRIM28. Together, our findings suggest that importin α has an essential role in the nuclear delivery and preferential HP1 interaction of TRIM28. - Highlights: • TRIM28 contains an NLS within the 462-494 amino acid region. • The nuclear import of TRIM28 is mediated by importin α/importin β1. • TRIM28 NLS overlaps with HP1 Box. • HP1 and importin α compete for binding to TRIM28

  12. Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box

    Energy Technology Data Exchange (ETDEWEB)

    Moriyama, Tetsuji; Sangel, Percival [Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085 (Japan); Yamaguchi, Hiroki [School of Medicine, Osaka University, Osaka 565-0871 (Japan); Obuse, Chikashi [Graduate School of Life Science, Hokkaido University, Sapporo 001-0021 (Japan); Miyamoto, Yoichi [Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085 (Japan); Oka, Masahiro, E-mail: moka@nibiohn.go.jp [Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085 (Japan); Laboratory of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871 (Japan); Yoneda, Yoshihiro, E-mail: y-yoneda@nibiohn.go.jp [National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085 (Japan); Laboratory of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871 (Japan)

    2015-07-03

    Tripartite motif-containing 28 (TRIM28) is a transcription regulator, which forms a repressor complex containing heterochromatin protein 1 (HP1). Here, we report identification of a nuclear localization signal (NLS) within the 462-494 amino acid region of TRIM28 that overlaps with its HP1 binding site, HP1 box. GST-pulldown experiments revealed the interaction of the arginine-rich TRIM28 NLS with various importin α subtypes (α1, α2 and α4). In vitro transport assay demonstrated that nuclear localization of GFP-TRIM28 NLS is mediated by importin αs, in conjunction with importin β1 and Ran. Further, we demonstrated that HP1 and importin αs compete for binding to TRIM28. Together, our findings suggest that importin α has an essential role in the nuclear delivery and preferential HP1 interaction of TRIM28. - Highlights: • TRIM28 contains an NLS within the 462-494 amino acid region. • The nuclear import of TRIM28 is mediated by importin α/importin β1. • TRIM28 NLS overlaps with HP1 Box. • HP1 and importin α compete for binding to TRIM28.

  13. Deep-water gamma-spectrometer based on HP(Ge) detector

    International Nuclear Information System (INIS)

    Sokolov, A.; Danengirsh, S.; Popov, S.; Pchelincev, A; Gostilo, V.; Kravchenko, S.; Shapovalov, V.; Druzhinin, A.

    1995-01-01

    Full text: For radionuclide monitoring of the sea bottom near underwater storage of high active waste of nuclear industries and near places of accidents with nuclear submarines the spectrometers of gamma-radiation, which allow to carry out the measurements on the great depth, are needed. Usually, these problems are solved with devices, which are cast down into the water, using the rope, and transmit the signals on the surface by the cable. However, the depth of immersion is limited by this construction and often the conditions of measurement are complicated. The deep water gamma-spectrometer based on HP(Ge) detector for the measurement on the depth up to 3000 m is developed. The spectrometer is completely autonomic and is put up in the selected place, using the manipulator of a deep-water apparatus. The spectrometer is created in two cylindrical cases with 170 mm diameter and 1100 mm length, bearing the high hydrostatic pressure. The part of the case around the detector is created from titanium and has especial construction with a thin wall for increasing the efficiency of registration in the region of low-energy gamma-radiation. The cooling of the semiconductor detector is provided by a coolant which supports the working temperature of the detector during more than 24 hours. The electronic system of the spectrometer includes high voltage supply f or the detector, preamplifier, analog processor, analog-digital converter and a device for collecting and storing information in flash memory. The power supply of the spectrometer is provided by a battery of accumulators, which can be recharged on the surface. The programming of the processor is carried out before immersion by connecting the spectrometer to personal computer using standard interface RS-232. During 24 hours the spectrometer provides registration of 16 spectrums each in 4096 channels. The reading of the information by the computer is carried out after lifting up the spectrometer on the surface in the same

  14. Comparison of four urease-dependent tests of detecting HP infection

    International Nuclear Information System (INIS)

    Han Yuan; Huang Gang; Zhu Cuiying; Ling Liqun

    2001-01-01

    Objective: The aim of this study is to compare the four urease-dependent tests of detecting Hp infection. The authors used following method: 1) rapid urease test (RUT), 2) 14 C urea breath test ( 14 C-UBT), 3) 13 C urea breath test which is measured by with infrared spectrometry ( 13 C-UBT1), 4) 13 C urea breath test with mass spectrometry ( 13 C-UBT). Methods: 54 patients underwent RUT, 14 C-UBT, 13 C-UBT1, 13 C-UBT2 respectively. Results: Sensitivity and specificity, accurate rate, positive predictive value (PPV), negative predictive value (NPV), respectively, were as follows: RUT (82.1%, 80%, 81.5%, 91.4%, 63.2%), 14 C-UBT (97.4%, 100%, 98.1%, 100%, 93.8%), 13 C-UBT1 (100%, 93.3%, 98.1%, 97.5%, 100%), 13 C-UBT2 (100%, 86.7%, 96.3%, 95.1%, 100%), PPV of four tests are not significantly different (P>0.05). Conclusion: Four urease-dependent tests are high sensitive and accurate methods for detecting Hp infection. UBT is an ideal tool for diagnosis, screen and follow-up of Hp infection

  15. Mutation of charged residues to neutral ones accelerates urea denaturation of HP-35.

    Science.gov (United States)

    Wei, Haiyan; Yang, Lijiang; Gao, Yi Qin

    2010-09-16

    Following the studies of urea denaturation of β-hairpins using molecular dynamics, in this paper, molecular dynamics simulations of two peptides, a 35 residue three helix bundle villin headpiece protein HP-35 and its doubly norleucine-substituent mutant (Lys24Nle/Lys29Nle) HP-35 NleNle, were undertaken in urea solutions to understand the molecular mechanism of urea denaturation of α-helices. The mutant HP-35 NleNle was found to denature more easily than the wild type. During the expansion of the small hydrophobic core, water penetration occurs first, followed by that of urea molecules. It was also found that the initial hydration of the peptide backbone is achieved through water hydrogen bonding with the backbone CO groups during the denaturation of both polypeptides. The mutation of the two charged lysine residues to apolar norleucine enhances the accumulation of urea near the hydrophobic core and facilitates the denaturation process. Urea also interacts directly with the peptide backbone as well as side chains, thereby stabilizing nonnative conformations. The mechanism revealed here is consistent with the previous study on secondary structure of β-hairpin polypeptide, GB1, PEPTIDE 1, and TRPZIP4, suggesting that there is a general mechanism in the denaturation of protein backbone hydrogen bonds by urea.

  16. Investigation of the three-dimensional lattice HP protein folding model using a genetic algorithm

    Directory of Open Access Journals (Sweden)

    Fábio L. Custódio

    2004-01-01

    Full Text Available An approach to the hydrophobic-polar (HP protein folding model was developed using a genetic algorithm (GA to find the optimal structures on a 3D cubic lattice. A modification was introduced to the scoring system of the original model to improve the model's capacity to generate more natural-like structures. The modification was based on the assumption that it may be preferable for a hydrophobic monomer to have a polar neighbor than to be in direct contact with the polar solvent. The compactness and the segregation criteria were used to compare structures created by the original HP model and by the modified one. An islands' algorithm, a new selection scheme and multiple-points crossover were used to improve the performance of the algorithm. Ten sequences, seven with length 27 and three with length 64 were analyzed. Our results suggest that the modified model has a greater tendency to form globular structures. This might be preferable, since the original HP model does not take into account the positioning of long polar segments. The algorithm was implemented in the form of a program with a graphical user interface that might have a didactical potential in the study of GA and on the understanding of hydrophobic core formation.

  17. Negative-tone imaging with EUV exposure for 14nm hp and beyond

    Science.gov (United States)

    Tsubaki, Hideaki; Nihashi, Wataru; Tsuchihashi, Toru; Fujimori, Toru; Momota, Makoto; Goto, Takahiro

    2015-03-01

    Manipulation of dissolution properties by changing organic solvent developer and rinse material provides a novel technology to obtain fine pattern beyond the limitation of imaging system based on alkaline developer. QCM study showed no swelling character in negative-tone imaging (NTI) process even for current developer of n-butyl acetate (nBA). Actually, NTI process has shown advantages on resolution and line-width roughness (LWR) in loose pitch around 30 ~ 45 nm hp as a consequence of its non-swelling character. On the other hand, bridge and collapse limited its resolution below 20 nm hp, indicating that non-negligible amount of swelling still exists for tight pitch resolution. We investigated effects of solubility parameter of organic solvents on resolution below 20 nm hp. A bridge was reduced with a decrease in the solubility parameter dp from nBA. On the other hand, much lower dp caused film remaining due to its extremely slow Rmax. Based on these results, we newly developed FN-DP301 containing organic solvent with smaller dp than nBA. Although rinse solvent gave negligible effects on bridge, there is a clear improvement on pattern collapse only in case of using new rinse solvent of FN-RP311. Lithographic performances of NTI process using nBA and FN-DP301 together with the other organic solvents were described in this paper under exposures with an E-beam and a EUV light. It is emphasized that 14 nm hp resolution was obtained only using FN-DP301 as a developer and FN-RP311 as a rinse under E-beam exposure. NTI showed 43% faster photospeed in comparison with PTI at 16 nm hp, indicating that NTI is applicable to obtain high throughput with maintaining resolution. In addition, sub-20 nm trench was obtained using NTI without bridge under EUV exposure, all of which are attributed to the low swelling character of NTI process. Similarly, NTI was able to print 20 nm dots using NXE:3100 with only a little peeling. Conversely CH patterning was significantly worse with NTI

  18. Notes on HP1 a software package for simulating variably-saturated water flow, heat transport, solute transport, and biogeochemistry in porous media. HP1 Version 2.2

    Energy Technology Data Exchange (ETDEWEB)

    Jacques, D.; Simunek, J.

    2010-01-15

    HP1 is a comprehensive modeling tool in terms of processes and reactions for simulating reactive transport and biogeochemical processes in variably-saturated porous media. HP1 results from coupling the water and solute transport model HYDRUS-1D (Simunek et al., 2009a) and PHREEQC-2 (Parkhurst and Appelo, 1999). This note provides an overview of how to set up and execute a HP1 project using version 2.2.002 of HP1 and version 4.13 of the graphical user interface (GUI) of HYDRUS-1D. A large part of this note are step-by-step instructions for selected examples involving mineral dissolution and precipitation, cation exchange, surface complexation and kinetic degradation networks. The implementation of variably-saturated flow conditions, changing boundary conditions, a layered soil profile or immobile water is also illustrated.

  19. Notes on HP1 a software package for simulating variably-saturated water flow, heat transport, solute transport, and biogeochemistry in porous media. HP1 Version 2.2

    International Nuclear Information System (INIS)

    Jacques, D.; Simunek, J.

    2010-01-01

    HP1 is a comprehensive modeling tool in terms of processes and reactions for simulating reactive transport and biogeochemical processes in variably-saturated porous media. HP1 results from coupling the water and solute transport model HYDRUS-1D (Simunek et al., 2009a) and PHREEQC-2 (Parkhurst and Appelo, 1999). This note provides an overview of how to set up and execute a HP1 project using version 2.2.002 of HP1 and version 4.13 of the graphical user interface (GUI) of HYDRUS-1D. A large part of this note are step-by-step instructions for selected examples involving mineral dissolution and precipitation, cation exchange, surface complexation and kinetic degradation networks. The implementation of variably-saturated flow conditions, changing boundary conditions, a layered soil profile or immobile water is also illustrated.

  20. VMEbus based computer and real-time UNIX as infrastructure of DAQ

    International Nuclear Information System (INIS)

    Yasu, Y.; Fujii, H.; Nomachi, M.; Kodama, H.; Inoue, E.; Tajima, Y.; Takeuchi, Y.; Shimizu, Y.

    1994-01-01

    This paper describes what the authors have constructed as the infrastructure of data acquisition system (DAQ). The paper reports recent developments concerned with HP VME board computer with LynxOS (HP742rt/HP-RT) and Alpha/OSF1 with VMEbus adapter. The paper also reports current status of developing a Benchmark Suite for Data Acquisition (DAQBENCH) for measuring not only the performance of VME/CAMAC access but also that of the context switching, the inter-process communications and so on, for various computers including Workstation-based systems and VME board computers

  1. Determination of effective dose in anisotropic gamma radiation fields: application of dosimeters calibrated in terms of Hp(10)

    International Nuclear Information System (INIS)

    Chumak, V. V.; Bakhanova, E. V.

    2003-01-01

    In this presentation authors deals with determination of effective dose in anisotropic gamma radiation fields. It was conclude that: - Straightforward application of Hp(10) as surrogate for E may not work under certain conditions; - Partial data on behavior of E and Hp(10) for different dosimeters allow to estimate E/Hp(10) conversion coefficients for any particular composite source; - In practical situations, anisotropy of workplace fields may be measured by six- collimator device assessing contribution to a dose from six orthogonal directions; - Reasonably conservative conversion coefficients may be assessed for given energy spectrum and degree of anisotropy of workplace fields; - For strongly anisotropic fields multiple dosimetry approach gives the best estimate of E comparing to plain Hp(10) readouts or integral conversion coefficients

  2. Effectiveness of computer-assisted interactive videodisc instruction in teaching rheumatology to physical and occupational therapy students.

    Science.gov (United States)

    Sanford, M K; Hazelwood, S E; Bridges, A J; Cutts, J H; Mitchell, J A; Reid, J C; Sharp, G

    1996-01-01

    A computer-assisted interactive videodisc instructional program, HP-RHEUM was designed to teach clinical findings in arthritis to occupational and physical therapy students. Using the Rheumatology Image Library videodisc produced by the National Library of Medicine, HP-RHEUM consists of instructional modules which employ advance organizers, examples/nonexamples, summaries, and immediate feedback. To see if HP-RHEUM would be as effective as traditional classroom instruction, control data were collected in 1991 from 52 OT and PT students. Treatment data were collected from 61 students in 1992 when HP-RHEUM entirely replaced lectures. Identical pre- and post-tests consisted of 70 multiple choice questions, with 24 matched to slides. On the slide questions the HP-RHEUM group had significantly higher scores. Otherwise, there was no significant difference in performance between groups. HP-RHEUM provided an independent learning method and enhanced visual comprehension of rheumatologic disease concepts.

  3. Analysis and development of spatial hp-refinement methods for solving the neutron transport equation; Analyse et developpement de methodes de raffinement hp en espace pour l'equation de transport des neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Fournier, D.

    2011-10-10

    The different neutronic parameters have to be calculated with a higher accuracy in order to design the 4. generation reactor cores. As memory storage and computation time are limited, adaptive methods are a solution to solve the neutron transport equation. The neutronic flux, solution of this equation, depends on the energy, angle and space. The different variables are successively discretized. The energy with a multigroup approach, considering the different quantities to be constant on each group, the angle by a collocation method called SN approximation. Once the energy and angle variable are discretized, a system of spatially-dependent hyperbolic equations has to be solved. Discontinuous finite elements are used to make possible the development of hp-refinement methods. Thus, the accuracy of the solution can be improved by spatial refinement (h-refinement), consisting into subdividing a cell into sub-cells, or by order refinement (p-refinement), by increasing the order of the polynomial basis. In this thesis, the properties of this methods are analyzed showing the importance of the regularity of the solution to choose the type of refinement. Thus, two error estimators are used to lead the refinement process. Whereas the first one requires high regularity hypothesis (analytical solution), the second one supposes only the minimal hypothesis required for the solution to exist. The comparison of both estimators is done on benchmarks where the analytic solution is known by the method of manufactured solutions. Thus, the behaviour of the solution as a regard of the regularity can be studied. It leads to a hp-refinement method using the two estimators. Then, a comparison is done with other existing methods on simplified but also realistic benchmarks coming from nuclear cores. These adaptive methods considerably reduces the computational cost and memory footprint. To further improve these two points, an approach with energy-dependent meshes is proposed. Actually, as the

  4. DhHP-6 extends lifespan of Caenorhabditis elegans by enhancing nuclear translocation and transcriptional activity of DAF-16.

    Science.gov (United States)

    Huang, Lei; Li, Pengfei; Wang, Guan; Guan, Shuwen; Sun, Xiaoli; Wang, Liping

    2013-04-01

    Earlier studies have demonstrated that Deuterohaemin-AlaHisThrValGluLys (DhHP-6), a novel porphyrin-peptide, increases lifespan and enhances stress resistance of Caenorhabditis elegans. To explore the possible mechanisms, in this study we investigated the roles of SIR-2.1 and DAF-16 in DhHP-6's function using wild-type and various other mutant strains of C. elegans. DhHP-6's effect was dependent upon DAF-16, and it did not extend the lifespan of the loss-of-function daf-16 mutant strain (daf-16(mu86) I). DhHP-6 enhanced DAF-16 translocation from cytoplasm to nuclei; and it increased DAF-16's transcriptional activity, likely by activating the SIR-2.1/DAF-16 complex. DhHP-6's effect was also dependent upon SIR-2.1, and it did not increase the lifespan of the worms with SIR-2.1 deacetylase activity inhibited by niacin amide (SIR-2.1 inhibitor) and SIR-2.1 RNA interference (RNAi). Niacin amide and RNAi increased DAF-16's nuclear localization; but they decreased DAF-16's transcriptional activity, likely by preventing the formation of the SIR-2.1/DAF-16 complex. These results suggest that DhHP-6 extends the lifespan of C. elegans via SIR 2.1 and DAF-16, and they provide new insights into the molecular mechanisms of aging.

  5. Social Computing

    CERN Multimedia

    CERN. Geneva

    2011-01-01

    The past decade has witnessed a momentous transformation in the way people interact with each other. Content is now co-produced, shared, classified, and rated by millions of people, while attention has become the ephemeral and valuable resource that everyone seeks to acquire. This talk will describe how social attention determines the production and consumption of content within both the scientific community and social media, how its dynamics can be used to predict the future and the role that social media plays in setting the public agenda. About the speaker Bernardo Huberman is a Senior HP Fellow and Director of the Social Computing Lab at Hewlett Packard Laboratories. He received his Ph.D. in Physics from the University of Pennsylvania, and is currently a Consulting Professor in the Department of Applied Physics at Stanford University. He originally worked in condensed matter physics, ranging from superionic conductors to two-dimensional superfluids, and made contributions to the theory of critical p...

  6. Mua (HP0868) Is a Nickel-Binding Protein That Modulates Urease Activity in Helicobacter pylori

    Science.gov (United States)

    Benoit, Stéphane L.; Maier, Robert J.

    2011-01-01

    A novel mechanism aimed at controlling urease expression in Helicobacter pylori in the presence of ample nickel is described. Higher urease activities were observed in an hp0868 mutant (than in the wild type) in cells supplemented with nickel, suggesting that the HP0868 protein (herein named Mua for modulator of urease activity) represses urease activity when nickel concentrations are ample. The increase in urease activity in the Δmua mutant was linked to an increase in urease transcription and synthesis, as shown by quantitative real-time PCR, SDS-PAGE, and immunoblotting against UreAB. Increased urease synthesis was also detected in a Δmua ΔnikR double mutant strain. The Δmua mutant was more sensitive to nickel toxicity but more resistant to acid challenge than was the wild-type strain. Pure Mua protein binds 2 moles of Ni2+ per mole of dimer. Electrophoretic mobility shift assays did not reveal any binding of Mua to the ureA promoter or other selected promoters (nikR, arsRS, 5′ ureB-sRNAp). Previous yeast two-hybrid studies indicated that Mua and RpoD may interact; however, only a weak interaction was detected via cross-linking with pure components and this could not be verified by another approach. There was no significant difference in the intracellular nickel level between wild-type and mua mutant cells. Taken together, our results suggest the HP0868 gene product represses urease transcription when nickel levels are high through an as-yet-uncharacterized mechanism, thus counterbalancing the well-described NikR-mediated activation. PMID:21505055

  7. pHP-Tethered N-Acyl Carbamate: A Photocage for Nicotinamide.

    Science.gov (United States)

    Salahi, Farbod; Purohit, Vatsal; Ferraudi, Guillermo; Stauffacher, Cynthia; Wiest, Olaf; Helquist, Paul

    2018-05-04

    The synthesis of a new photocaged nicotinamide having an N-acyl carbamate linker and a p-hydroxyphenacyl (pHP) chromophore is described. The photophysical and photochemical studies showed an absorption maximum at λ = 330 nm and a quantum yield for release of 11% that are dependent upon both pH and solvent. While the acyl carbamate releases nicotinamide efficiently, a simpler amide linker was inert to photocleavage. This photocaged nicotinamide has significant advantages with respect to quantum yield, absorbance wavelength, rate of release, and solubility that make it the first practical example of a photocaged amide.

  8. Microstructure of Magnesium alloy AZ91-HP cast in permanent and non-permanent moulds

    DEFF Research Database (Denmark)

    Tiedje, Niels; Sørensen, Rasmus Kirkegaard; Albachari, Sami

    2003-01-01

    Casting of different geometries were made with AZ91-HP in different moulding media, so that a range of cooling conditions were obtained. Cooling curves were measured and compared to the microstructures found in the castings. It was shown that segregation in the alloy is highly dependent on cooling...... rate. This leads to precipitation of varying amounts of intermetallic phases. The distribution of phases in the material is controlled both by interdendritic and intergranular segregation, leading to an inhomogeneous microstructure. It is shown that local solidification time, segregation and diffusion...

  9. A point kernel shielding code, PKN-HP, for high energy proton incident

    Energy Technology Data Exchange (ETDEWEB)

    Kotegawa, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1996-06-01

    A point kernel integral technique code PKN-HP, and the related thick target neutron yield data have been developed to calculate neutron and secondary gamma-ray dose equivalents in ordinary concrete and iron shields for fully stopping length C, Cu and U-238 target neutrons produced by 100 MeV-10 GeV proton incident in a 3-dimensional geometry. The comparisons among calculation results of the present code and other calculation techniques, and measured values showed the usefulness of the code. (author)

  10. Silent decision: HP1 protein escorts heterochromatic RNAs to their destiny

    Science.gov (United States)

    Ren, Jie; Martienssen, Robert A

    2012-01-01

    EMBO J advance online publication 06072012; doi:10.1016/j.molcel.2012.05.009 Heterochromatin is classically perceived to be refractory to transcription because of its compact structure. However, Keller et al (2012) now demonstrated that heterochromatic transcripts can accumulate even when heterochromatin is normally packaged. By tracking down the fate of these heterochromatic RNAs, they revealed a new post-transcriptional mechanism of silencing in heterochromatin that involves the dynamic turnover of HP1Swi6 between its free, chromatin-bound and RNA-bound forms. The latter form escorts heterochromatic RNA to degradation. PMID:22705945

  11. Application of a Long Term Asset Management Strategy for HP Feedwater Heaters

    International Nuclear Information System (INIS)

    Won, Se Youl; Yun, Eun Sub; Park, Young Sheop

    2008-01-01

    As the commercial operating year of nuclear power plants is increased, it becomes imperative to develop integrated cost-effective asset management and to improve plans for degraded Structures, Systems, and Components (SSCs) in terms of safety and economical consideration. A long-term asset management (LTAM) strategy can improve the condition of nuclear plants, maximize their value, and optimize their operational life by maintaining their safety. This paper presents an optimized LTAM plan for HP feedwater heaters at a specific nuclear power plant

  12. The Spectral/hp-Finite Element Method for Partial Differential Equations

    DEFF Research Database (Denmark)

    Engsig-Karup, Allan Peter

    2009-01-01

    dimensions. In the course the chosen programming environment is Matlab, however, this is by no means a necessary requirement. The mathematical level needed to grasp the details of this set of notes requires an elementary background in mathematical analysis and linear algebra. Each chapter is supplemented......This set of lecture notes provides an elementary introduction to both the classical Finite Element Method (FEM) and the extended Spectral/$hp$-Finite Element Method for solving Partial Differential Equations (PDEs). Many problems in science and engineering can be formulated mathematically...

  13. Mechanical behaviour of Astm A 297 grade Hp joints welded using different processes

    International Nuclear Information System (INIS)

    Emygdio, Paulo Roberto Oliveira; Zeemann, Annelise; Almeida, Luiz Henrique de

    1996-01-01

    The influence of different arc welding processes on mechanical behaviour was studied for cast heat resistant stainless steel welded joints, in the as welded conditions. ASTM A 297 grade HP with niobium and niobium/titanium additions were welded following three different welding procedures, using shielded metal arc welding gas tungsten arc welding and plasma arc welding, in six welded joints. The welded joint mechanical behaviour was evaluated by ambient temperature and 870 deg C tensile tests; and creep tests at 900 deg C and 50 MPa. Mechanical test results showed that the welding procedure qualification following welding codes is not suitable for high temperature service applications. (author)

  14. Quantification of bitumen particles in aerosol and soil samples using HP-GPC

    DEFF Research Database (Denmark)

    Fauser, Patrik; Tjell, Jens Christian; Mosbæk, Hans

    2000-01-01

    A method for identifying and quantifying bitumen particles, generated from the wear of roadway asphalts, in aerosol and soil samples has been developed. Bitumen is found to be the only contributor to airborne particles containing organic molecules with molecular weights larger than 2000 g pr. mol....... These are separated and identified using High Performance Gel Permeation Chromatography (HP-GPC) with fluorescence detection. As an additional detection method Infra Red spectrometry (IR) is employed for selected samples. The methods have been used on aerosol, soil and other samples....

  15. Effect of hypoproteinemia (HP) upon FT4 and FT3 by kinetic radioligandassay (RLA)

    International Nuclear Information System (INIS)

    Bottger, I.G.; Schneck, H.J.

    1985-01-01

    HP, especially hypoalbuminemia (HA), has been associated with false low FT4 by RLA, predominantly of the analogue tracer type. Based upon previous more favourable findings in severe nonthyroidal illness (NTI), this study was designed to study this problem in more detail. Two groups of patients with severe NTI (polytrauma) were selected on the basis of their total serum protein (TSP) concentration and studied during intensive-care. Group I: N = 25, TSP 5.9 g/dl (6.0 - 7.7), A/G: 1.5, sera: N = 76. I and II: low-dose heparin (i.v. 5000 U/24 h), non-detectable in the periphery. The RLA kits used were: FT4/T4 and FT3/T3 (kinetic two-tube), and TBG, Corning Medical, rT3, Serono, TSH, Henning-Berlin, TSP/electrophoresis standard technique. The findings indicate: 1. Typical findings for follow-up of severe NTI; 2. No detection of a significant effect of HP/HA upon these RLAs for FT4 and FT3; and 3. The inter-group differences are most likely due to more severe NT1 in I (R/sub x/, A/G, rT3)

  16. Spectral/hp least-squares finite element formulation for the Navier-Stokes equations

    International Nuclear Information System (INIS)

    Pontaza, J.P.; Reddy, J.N.

    2003-01-01

    We consider the application of least-squares finite element models combined with spectral/hp methods for the numerical solution of viscous flow problems. The paper presents the formulation, validation, and application of a spectral/hp algorithm to the numerical solution of the Navier-Stokes equations governing two- and three-dimensional stationary incompressible and low-speed compressible flows. The Navier-Stokes equations are expressed as an equivalent set of first-order equations by introducing vorticity or velocity gradients as additional independent variables and the least-squares method is used to develop the finite element model. High-order element expansions are used to construct the discrete model. The discrete model thus obtained is linearized by Newton's method, resulting in a linear system of equations with a symmetric positive definite coefficient matrix that is solved in a fully coupled manner by a preconditioned conjugate gradient method. Spectral convergence of the L 2 least-squares functional and L 2 error norms is verified using smooth solutions to the two-dimensional stationary Poisson and incompressible Navier-Stokes equations. Numerical results for flow over a backward-facing step, steady flow past a circular cylinder, three-dimensional lid-driven cavity flow, and compressible buoyant flow inside a square enclosure are presented to demonstrate the predictive capability and robustness of the proposed formulation

  17. PENINGKATAN CD8 DAN IFN-γ PADA HYPERSENSITIVITY PNEUMONITIS (HP AKIBAT PAJANAN DEBU PENGGILINGAN PADI

    Directory of Open Access Journals (Sweden)

    Isa Ma'rufi

    2017-10-01

    Full Text Available Abstrak     Masalah klinis kesehatan kerja pada pekerja penggilingan padi saat ini adalah penyakit saluran pernafasan. Penelitian ini bertujuan untuk menganalisis peningkatan CD8 dan IFN-γ pada Pneumonitis Hipersensitif (HP akibat pajanan debu penggilingan padi pada mencit  (Musmusculus BALB/C. Penelitian yang dilakukan adalah penelitian eksperimental laboratoris dengan hewan coba mencit (Musmusculus BALB/C,  rancangan penelitian yang digunakan adalah Randomized the post test only control group design. Mencit  (Musmusculus BALB/C dipajan dengan debu penggilingan padi selama empat jam/hari selama tiga puluh hari dengan konsentrasi 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3. Variabel bebas adalah debu penggilingan padi, sedangkan variabel tergantung adalah   CD8 dan IFN-γ, serta gambaran histopatologis paru mencit, sedangkan variabel kendali adalah strain, berat badan, dan umur. Hasil penelitian menunjukkan bahwa terjadi peningkatan kadar CD8 antara kontrol dengan perlakuan, dan secara statistik  ada perbedaan yang bermakna. Kemudian terjadi peningkatan IFN-γ dan secara statistik ada perbedaan yang bermakna antara kontrol dan perlakuan pada mencit  (Musmusculus BALB/C. Hasil penelitian dapat digunakan sebagai dasar upaya pencegahan dan pemberian terapi penyakit HP lebih dini sehingga dapat meningkatkan kualitas paru.   Kata Kunci: CD8, IFN-γ,  debu penggilingan padi     Abtract   The purpose of this research was to analyze increase of CD8  and IFN-γ of Hypersensitivity Pneumonitis (HP as a result from the exposure of dust from paddy milling on mice (MusmusculusBALB/C. The research done was a laboratory experimental research with mice (MusMusculus as experimental animal.  The research design used was the post only control group design using mice (MusMusculus Balb/c as experimental animal.  Mice (Musmusculus Balb/c were exposed to dust from paddy milling for four (4 hours/day and it was done for thirty (30 days with the exposed

  18. Proposal of concentration limits for determining the hazard property HP 14 for waste using ecotoxicological tests.

    Science.gov (United States)

    Hennebert, Pierre

    2018-04-01

    Different ecotoxicological test batteries and concentration limits have been proposed to assess the hazard property (HP) HP 14 'Ecotoxic' for waste in the European Union and its member states. In test batteries, if the concentration of waste in the culture/dilution medium producing 50% of inhibitory biological effect in one or more test(s) is below the concentration limit of the test, the waste is classified as hazardous. A summarized review of the test batteries proposed since 1998 is presented. The last proposed test battery uses seven aquatic and terrestrial species with standardized methods, but with options and uniform concentration limits of 10% of waste eluate or solid waste in the culture/dilution medium. No attempt was made to match this hazard assessment with the classification made in the European List of Waste (LoW). The aim of this paper is to propose for the same test battery (reduced to 6 tests without options) concentration limits that match with the European List of Waste. This list was taken as reference (despite the fact that waste can be hazardous for other properties than the most frequent HP 14, and its partly political nature for some opinions). The concentration limits (CLs) for tests are the concentrations producing the highest ecotoxicological effects for each test observed in a non-hazardous waste set. Data from Germany, France and Belgium (from in total 5 different sources from 2009 to 2016) with the above-mentioned test battery (without options) were gathered for 81 samples, being the largest set ever published. In total, ten non-hazardous (NH) waste samples (as defined by the LoW and for most of them checked by chemical composition) were used to establish CLs. These CLs were then applied to 13 hazardous (H) waste by the LoW, and all were classified as hazardous. The matching of the resulting classification with the LoW is convincing. For the 58 'mirror entries' in the LoW (hazardous or not depending of the presence of hazardous

  19. HP-HMG versus rFSH in treatments combining fresh and frozen IVF cycles: success rates and economic evaluation.

    Science.gov (United States)

    Wex-Wechowski, Jaro; Abou-Setta, Ahmed M; Kildegaard Nielsen, Sandy; Kennedy, Richard

    2010-08-01

    The economic implications of the choice of gonadotrophin influence decision making but their cost-effectiveness in frozen-embryo transfer cycles has not been adequately studied. An economic evaluation was performed comparing highly purified human menopausal gonadotrophin (HP-HMG) and recombinant FSH (rFSH) using individual patient data (n=986) from two large randomized controlled trials using a long agonist IVF protocol. The simulation model incorporated live birth data and published UK costs of IVF-related medical resources. After treatment for up-to-three cycles (one fresh and up to two subsequent fresh or frozen cycles conditional on availability of cryopreserved embryos), the cumulative live birth rate was 53.7% (95% CI 49.3-58.1%) for HP-HMG and 44.6% (40.2-49.0%) for rFSH (OR 1.44, 95% CI 1.12-1.85; Pcosts per IVF treatment for HP-HMG and rFSH were pound5393 ( pound5341-5449) and pound6269 ( pound6210-6324), respectively (number needed to treat to fund one additional treatment was seven; Pcosts applied, the median cost per IVF baby delivered with HP-HMG was pound11,157 ( pound11,089-11,129) and pound14,227 ( pound14,183-14,222) with rFSH (Pcost saving using HP-HMG remained after varying model parameters in a probabilistic sensitivity analysis. 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  20. Performance of Partial and Cavity Type Squealer Tip of a HP Turbine Blade in a Linear Cascade

    Directory of Open Access Journals (Sweden)

    Levent Kavurmacioglu

    2018-01-01

    Full Text Available Three-dimensional highly complex flow structure in tip gap between blade tip and casing leads to inefficient turbine performance due to aerothermal loss. Interaction between leakage vortex and secondary flow structures is the substantial source of that loss. Different types of squealer tip geometries were tried in the past, in order to improve turbine efficiency. The current research deals with comparison of partial and cavity type squealer tip concepts for higher aerothermal performance. Effects of squealer tip have been examined comprehensively for an unshrouded HP turbine blade tip geometry in a linear cascade. In the present paper, flow structure through the tip gap was comprehensively investigated by computational fluid dynamic (CFD methods. Numerical calculations were obtained by solving three-dimensional, incompressible, steady, and turbulent form of the Reynolds-averaged Navier-Stokes (RANS equations using a general purpose and three-dimensional viscous flow solver. The two-equation turbulence model, shear stress transport (SST, has been used. The tip profile belonging to the Pennsylvania State University Axial Flow Turbine Research Facility (AFTRF was used to create an extruded solid model of the axial turbine blade. For identifying optimal dimensions of squealer rim in terms of squealer height and squealer width, our previous studies about aerothermal investigation of cavity type squealer tip were utilized. In order to obtain the mesh, an effective parametric generation has been utilized using a multizone structured mesh. Numerical calculations indicate that partial and cavity squealer designs can be effective to reduce the aerodynamic loss and heat transfer to the blade tip. Future efforts will include novel squealer shapes for higher aerothermal performance.

  1. User manual of the multicompenent variably - saturated flow and transport model HP1

    International Nuclear Information System (INIS)

    Jacques, D.; Simunek, J.

    2005-06-01

    This report describes a new comprehensive simulation tool HP1 (HYDRUS1D-PHREEQC) that was obtained by coupling the HYDRUS-1D one-dimensional variably-saturated water flow and solute transport model with the PHREEQC geochemical code. The HP1 code incorporates modules simulating (1) transient water flow in variably-saturated media, (2) transport of multiple components, and (3) mixed equilibrium/kinetic geochemical reactions. The program numerically solves the Richards equation for variably-saturated water flow and advection-dispersion type equations for heat and solute transport. The flow equation incorporates a sink term to account for water uptake by plant roots. The heat transport equation considers transport due to conduction and convection with flowing water. The solute transport equations consider advective-dispersive transport in the liquid phase. The program can simulate a broad range of low-temperature biogeochemical reactions in water, soil and ground water systems including interactions with minerals, gases, exchangers, and sorption surfaces, based on thermodynamic equilibrium, kinetics, or mixed equilibrium-kinetic reactions. The program may be used to analyze water and solute movement in unsaturated, partially saturated, or fully saturated porous media. The flow region may be composed of nonuniform soils or sediments. Flow and transport can occur in the vertical, horizontal, or a generally inclined direction. The water flow part of the model can deal with prescribed head and flux boundaries, boundaries controlled by atmospheric conditions, as well as free drainage boundary conditions. The governing flow and transport equations were solved numerically using Galerkin-type linear finite element schemes. To test the accuracy of the coupling procedures implemented in HP1, simulation results were compared with (i) HYDRUS-1D for transport problems of multiple components subject to sequential first-order decay, (ii) PHREEQC for steady-state flow conditions, and

  2. A study on directional resistivity logging-while-drilling based on self-adaptive hp-FEM

    Science.gov (United States)

    Liu, Dejun; Li, Hui; Zhang, Yingying; Zhu, Gengxue; Ai, Qinghui

    2014-12-01

    Numerical simulation of resistivity logging-while-drilling (LWD) tool response provides guidance for designing novel logging instruments and interpreting real-time logging data. In this paper, based on self-adaptive hp-finite element method (hp-FEM) algorithm, we analyze LWD tool response against model parameters and briefly illustrate geosteering capabilities of directional resistivity LWD. Numerical simulation results indicate that the change of source spacing is of obvious influence on the investigation depth and detecting precision of resistivity LWD tool; the change of frequency can improve the resolution of low-resistivity formation and high-resistivity formation. The simulation results also indicate that the self-adaptive hp-FEM algorithm has good convergence speed and calculation accuracy to guide the geologic steering drilling and it is suitable to simulate the response of resistivity LWD tools.

  3. Improved Functional Properties and Efficiencies of Nitinol Wires Under High-Performance Shape Memory Effect (HP-SME)

    Science.gov (United States)

    Casati, R.; Saghafi, F.; Biffi, C. A.; Vedani, M.; Tuissi, A.

    2017-10-01

    Martensitic Ti-rich NiTi intermetallics are broadly used in various cyclic applications as actuators, which exploit the shape memory effect (SME). Recently, a new approach for exploiting austenitic Ni-rich NiTi shape memory alloys as actuators was proposed and named high-performance shape memory effect (HP-SME). HP-SME is based on thermal recovery of de-twinned martensite produced by mechanical loading of the parent phase. The aim of the manuscript consists in evaluating and comparing the fatigue and actuation properties of austenitic HP-SME wires and conventional martensitic SME wires. The effect of the thermomechanical cycling on the actuation response and the changes in the electrical resistivity of both shape memory materials were studied by performing the actuation tests at different stages of the fatigue life. Finally, the changes in the transition temperatures before and after cycling were also investigated by differential calorimetric tests.

  4. Studying the Efficiency of XAD-7HP Anionic Resin in the Extraction of Humic Acid from Surface Water

    Directory of Open Access Journals (Sweden)

    Hassan Hashemi

    2017-09-01

    Results: The average extraction efficiency for XAD-7HP was 77% and HA concentration determined in all seasons ranges from 0.15 to 0.29 mg/L in raw water. Conclusions: From the findings of this study, it can be concluded that the use of XAD-7HP is a proper and effective method for the extraction of HS and its extraction efficiency is more influenced by pH and turbidity than other parameters. It can also be deduced from this study that XAD-7HP resin was most efficient at a pH of 2 and an increase in turbidity resulted in a corresponding decrease in the efficiency of resin.

  5. An hp-local Discontinuous Galerkin Method for Parabolic Integro-Differential Equations

    KAUST Repository

    Pani, Amiya K.

    2010-06-06

    In this article, a priori error bounds are derived for an hp-local discontinuous Galerkin (LDG) approximation to a parabolic integro-differential equation. It is shown that error estimates in L 2-norm of the gradient as well as of the potential are optimal in the discretizing parameter h and suboptimal in the degree of polynomial p. Due to the presence of the integral term, an introduction of an expanded mixed type Ritz-Volterra projection helps us to achieve optimal estimates. Further, it is observed that a negative norm estimate of the gradient plays a crucial role in our convergence analysis. As in the elliptic case, similar results on order of convergence are established for the semidiscrete method after suitably modifying the numerical fluxes. The optimality of these theoretical results is tested in a series of numerical experiments on two dimensional domains. © 2010 Springer Science+Business Media, LLC.

  6. Crystallography and Morphology of Niobium Carbide in As-Cast HP-Niobium Reformer Tubes

    Science.gov (United States)

    Buchanan, Karl G.; Kral, Milo V.

    2012-06-01

    The microstructures of two as-cast heats of niobium-modified HP stainless steels were characterized. Particular attention was paid to the interdendritic niobium-rich carbides formed during solidification of these alloys. At low magnifications, these precipitates are grouped in colonies of similar lamellae. Higher magnifications revealed that the lamellae actually obtain two distinct morphologies. The type I morphology exhibits broad planar interfaces with a smooth platelike shape. Type II lamellae have undulating interfaces and an overall reticulated shape. To provide further insight into the origin of these two different morphologies, the microstructure and crystallography of each have been studied in detail using high resolution scanning electron microscopy, transmission electron microscopy, various electron diffraction methods (electron backscatter diffraction (EBSD), selected area diffraction (SAD), and convergent beam electron diffraction (CBED)), and energy dispersive X-ray spectroscopy.

  7. Investigation of HP Turbine Blade Failure in a Military Turbofan Engine

    Science.gov (United States)

    Mishra, R. K.; Thomas, Johny; Srinivasan, K.; Nandi, Vaishakhi; Bhatt, R. Raghavendra

    2017-04-01

    Failure of a high pressure (HP) turbine blade in a military turbofan engine is investigated to determine the root cause of failure. Forensic and metallurgical investigations are carried out on the affected blades. The loss of coating and the presence of heavily oxidized intergranular fracture features including substrate material aging and airfoil curling in the trailing edge of a representative blade indicate that the coating is not providing adequate oxidation protection and the blade material substrate is not suitable for the application at hand. Coating spallation followed by substrate oxidation and aging leading to intergranular cracking and localized trailing edge curling is the root cause of the blade failure. The remaining portion of the blade fracture surface showed ductile overload features in the final failure. The damage observed in downstream components is due to secondary effects.

  8. On the Realization of First-Order Current-Mode AP/HP Filter

    Directory of Open Access Journals (Sweden)

    W. Tangsrirat

    2013-12-01

    Full Text Available A compact circuit topology for the realization of the current-mode first-order allpass (AP and highpass (HP filters is described. The proposed circuit contains a minimum number of components, i.e., eight bipolar transistors and one grounded capacitor. The advantages of this circuit are the use of only grounded capacitor as a passive element, the electronic tunability of its parameters and its potential for low-voltage operation. Some simulation results are also reported, which demonstrate the effectiveness of the proposed circuit. Owing to the pole frequency of the filter circuit is normally dependent on temperature; a low-voltage translinear–based current source circuit for temperature compensation is also suggested.

  9. Analyzing powers in the dd→3Hen(3Hp) reactions at intermediate energies

    International Nuclear Information System (INIS)

    Ladygin, V. P.; Kiselev, A. S.; Kurilkin, A. K.; Vasiliev, T. A.; Isupov, A. Yu.; Ladygina, N. B.; Malakhov, A. I.; Reznikov, S. G.; Uesaka, T.; Saito, T.; Hatano, M.; Kato, H.; Sakoda, S.; Uchigashima, N.; Yako, K.; Janek, M.; Maeda, Y.; Nishikawa, J.; Ohnishi, T.; Sakamoto, N.

    2008-01-01

    Data for the deuteron analyzing powers in the dd→ 3 Hen( 3 Hp) reactions obtained at 140-270 MeV are discussed. The observed negative sign of the tensor analyzing powers A yy , A xx and A xz at small angles clearly demonstrate the sensitivity to the ratio of the D and S state components of the 3 He wave function. The behavior of the tensor analyzing powers at backward angles is sensitive to the short-range spin structure of the deuteron. However, the one-nucleon exchange calculations using standard 3 He and deuteron wave functions fail to reproduce the strong variation of the tensor analyzing powers as a function of angle in the cms. Sensitivity to relativistic effects is also discussed

  10. Discontinuous Galerkin discretization and hp-refinement for the resolution of the neutron transport equation

    International Nuclear Information System (INIS)

    Fournier, Damien; Le-Tellier, Romain; Herbin, Raphaele

    2013-01-01

    This paper presents an hp-refinement method for a first order scalar transport reaction equation discretized by a discontinuous Galerkin method. First, the theoretical rates of convergence of h- and p-refinement are recalled and numerically tested. Then, in order to design some meshes, we propose two different estimators of the local error on the spatial domain. These quantities are analyzed and compared depending on the regularity of the solution so as to find the best way to lead the refinement process and the best strategy to choose between h- and p-refinement. Finally, the different possible refinement strategies are compared first on analytical examples and then on realistic applications for neutron transport in a nuclear reactor core. (authors)

  11. Test report for run-in acceptance testing of Project W-151 300 HP mixing pumps

    International Nuclear Information System (INIS)

    Berglin, B.G.

    1998-01-01

    This report documents the results of a performance demonstration and operational checkout of three 300 HP mixer pumps in accordance with WHC-SD-WI51-TS-001 ''Mixer Pump Test Specification for Project W-151'' and Statement of Work 8K520-EMN-95-004 ''Mixer Pump Performance Demonstration at MASF'' in the 400 Area Maintenance and Storage Facility (MASF) building. Testing of the pumps was performed by Fast Flux Test Facility (FFTF) Engineering and funded by the Tank Waste Remediation System (TWRS) Project W-151. Testing began with the first pump on 04-01-95 and ended with the third pump on 11-01-96. Prior to testing, the MASF was modified and prepared to meet the pump testing requirements set forth by the Test Specification and the Statement of Work

  12. Programs for data processing in radioimmunoassay using the HP-41C programmable calculator

    International Nuclear Information System (INIS)

    1981-09-01

    The programs described provide for analysis, with the Hewlett Packard HP-41C calculator, of counting data collected in radioimmunoassays or other related in-vitro assays. The immediate reason for their development was to assist laboratories having limited financial resources and serious problems of quality control. The programs are structured both for ''off-line'' use, with manual entry of counting data into the calculator through the keyboard, and, in a slightly altered version, for ''on-line'' use, with automatic data entry from an automatic well scintillation counter originally designed at the IAEA. Only the off-line variant of the programs is described. The programs determine from appropriate counting data the concentration of analyte in unknown specimens, and provide supplementary information about the reliability of these results and the consistency of current and past assay performance

  13. An hp-local Discontinuous Galerkin Method for Parabolic Integro-Differential Equations

    KAUST Repository

    Pani, Amiya K.; Yadav, Sangita

    2010-01-01

    In this article, a priori error bounds are derived for an hp-local discontinuous Galerkin (LDG) approximation to a parabolic integro-differential equation. It is shown that error estimates in L 2-norm of the gradient as well as of the potential are optimal in the discretizing parameter h and suboptimal in the degree of polynomial p. Due to the presence of the integral term, an introduction of an expanded mixed type Ritz-Volterra projection helps us to achieve optimal estimates. Further, it is observed that a negative norm estimate of the gradient plays a crucial role in our convergence analysis. As in the elliptic case, similar results on order of convergence are established for the semidiscrete method after suitably modifying the numerical fluxes. The optimality of these theoretical results is tested in a series of numerical experiments on two dimensional domains. © 2010 Springer Science+Business Media, LLC.

  14. Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway

    OpenAIRE

    Garfinkel, Benjamin P.; Arad, Shiri; Le, Phuong T.; Bustin, Michael; Rosen, Clifford J.; Gabet, Yankel; Orly, Joseph

    2015-01-01

    Heterochromatin protein 1 binding protein 3 (HP1BP3) is a recently described histone H1-related protein with roles in chromatin structure and transcriptional regulation. To explore the potential physiological role of HP1BP3, we have previously described an Hp1bp3?/? mouse model with reduced postnatal viability and growth. We now find that these mice are proportionate dwarfs, with reduction in body weight, body length, and organ weight. In addition to their small size, microcomputed tomography...

  15. Assessment of four calculation methods proposed by the EC for waste hazardous property HP 14 'Ecotoxic'.

    Science.gov (United States)

    Hennebert, Pierre; Humez, Nicolas; Conche, Isabelle; Bishop, Ian; Rebischung, Flore

    2016-02-01

    Legislation published in December 2014 revised both the List of Waste (LoW) and amended Appendix III of the revised Waste Framework Directive 2008/98/EC; the latter redefined hazardous properties HP 1 to HP 13 and HP 15 but left the assessment of HP 14 unchanged to allow time for the Directorate General of the Environment of the European Commission to complete a study that is examining the impacts of four different calculation methods for the assessment of HP 14. This paper is a contribution to the assessment of the four calculation methods. It also includes the results of a fifth calculation method; referred to as "Method 2 with extended M-factors". Two sets of data were utilised in the assessment; the first (Data Set #1) comprised analytical data for 32 different waste streams (16 hazardous (H), 9 non-hazardous (NH) and 7 mirror entries, as classified by the LoW) while the second data set (Data Set #2), supplied by the eco industries, comprised analytical data for 88 waste streams, all classified as hazardous (H) by the LoW. Two approaches were used to assess the five calculation methods. The first approach assessed the relative ranking of the five calculation methods by the frequency of their classification of waste streams as H. The relative ranking of the five methods (from most severe to less severe) is: Method 3>Method 1>Method 2 with extended M-factors>Method 2>Method 4. This reflects the arithmetic ranking of the concentration limits of each method when assuming M=10, and is independent of the waste streams, or the H/NH/Mirror status of the waste streams. A second approach is the absolute matching or concordance with the LoW. The LoW is taken as a reference method and the H wastes are all supposed to be HP 14. This point is discussed in the paper. The concordance for one calculation method is established by the number of wastes with identical classification by the considered calculation method and the LoW (i.e. H to H, NH to NH). The discordance is

  16. Calculation of conversion coefficients Hp(3)/K air using the PENELOPE Monte Carlo code and comparison with MCNP calculation results

    International Nuclear Information System (INIS)

    Daures, J.; Gouriou, J.; Bordy, J.M.

    2010-01-01

    The authors report calculations performed using the MNCP and PENELOPE codes to determine the Hp(3)/K air conversion coefficient which allows the Hp(3) dose equivalent to be determined from the measured value of the kerma in the air. They report the definition of the phantom, a 20 cm diameter and 20 cm high cylinder which is considered as representative of a head. Calculations are performed for an energy range corresponding to interventional radiology or cardiology (20 keV-110 keV). Results obtained with both codes are compared

  17. Helicobacter pylori antigen HP0986 (TieA) interacts with cultured gastric epithelial cells and induces IL8 secretion via NF-κB mediated pathway.

    Science.gov (United States)

    Devi, Savita; Ansari, Suhail A; Vadivelu, Jamuna; Mégraud, Francis; Tenguria, Shivendra; Ahmed, Niyaz

    2014-02-01

    The envisaged roles and partly understood functional properties of Helicobacter pylori protein HP0986 are significant in the context of proinflammatory and or proapoptotic activities, the two important facilitators of pathogen survival and persistence. In addition, sequence analysis of this gene predicts a restriction endonuclease function which remained unknown thus far. To evaluate the role of HP0986 in gastric inflammation, we studied its expression profile using a large number of clinical isolates but a limited number of biopsies and patient sera. Also, we studied antigenic role of HP0986 in altering cytokine responses of human gastric epithelial (AGS) cells including its interaction with and localization within the AGS cells. For in vitro expression study of HP0986, 110 H. pylori clinical isolates were cultured from patients with functional dyspepsia. For expression analysis by qRT PCR of HP0986, 10 gastric biopsy specimens were studied. HP0986 was also used to detect antibodies in patient sera. AGS cells were incubated with recombinant HP0986 to determine cytokine response and NF-κB activation. Transient transfection with HP0986 cloned in pEGFPN1 was used to study its subcellular localization or homing in AGS cells. Out of 110 cultured H. pylori strains, 34 (31%) were positive for HP0986 and this observation was correlated with in vitro expression profiles. HP0986 mRNA was detected in 7 of the 10 biopsy specimens. Further, HP0986 induced IL-8 secretion in gastric epithelial cells in a dose and time-dependent manner via NF-κB pathway. Serum antibodies against HP0986 were positively associated with H. pylori positive patients. Transient transfection of AGS cells revealed both cytoplasmic and nuclear localization of HP0986. HP0986 was moderately prevalent in clinical isolates and its expression profile in cultures and gastric biopsies points to its being naturally expressed. Collective observations including the induction of IL-8 via TNFR1 and NF

  18. Design and realisation of a microprogramme for the analysis of nuclear spectroscopic data on the intelligent terminal, H.P.2648A

    International Nuclear Information System (INIS)

    Tendeku, F.K.

    1980-01-01

    A microprogramme has been developed for the analysis of nuclear spectroscopic data on the microprocessor-controlled terminal, H.P. 2648A. The terminal enables data to be processed locally. Many operations normally requiring connection to a computer can be performed on a stand alone basis. The principal aspects of the microprogramme are the graphical display of spectral data, the automatic and manual extraction of peaks, and the determination of peak characteristics. Among the features of the microprogramme are algorithms which enable a rapid graphical display of data in logarithmic and linear scales and in divers modes as well as functions enabling image amplification. The automatic peak searching algorithm represents a modified form of the Mariscotti method. The peak analysis procedure offers two options. The first makes use of the data directly. The second is based on the determination of the parameters of the gaussian function which best fits the data points, using the non-linear least squares principle. The terminal has been successfully interfaced to an IBM 370 computer through a satellite computer using the Parallel Duplex Register module of Hewlett Packard [fr

  19. Fate and transport of mercury in soil systems : a numerical model in HP1 and sensitivity analysis

    Science.gov (United States)

    Leterme, Bertrand; Jacques, Diederik

    2013-04-01

    speciation data on a contaminated sites would be required, together with a good characterization of the pollution source. References : Blanc, P., Lassin, A. and Piantone, P. (2012), THERMODDEM a database devoted to waste minerals, BRGM, Orléans, France. http://thermoddem.brgm.fr Campolongo, F., Cariboni, J. and Saltelli, A. (2007), An effective screening design for sensitivity analysis of large models, Environmental Modelling & Software 22(10): 1509-1518. Jacques, D. and Šimůnek, J. (2010), Notes on HP1 - a software package for simulating variably-saturated water flow, heat transport, solute transport and biogeochemistry in porous media, HP1 Version 2.2 SCK•CEN-BLG-1068, Waste & Disposal Department, SCK•CEN, Mol, Belgium: 113 p. Morris, M. D. (1991), Factorial Sampling Plans for Preliminary Computational Experiments, Technometrics 33(2): 161-174. Skyllberg, U. (2012), Chemical Speciation of Mercury in Soil and Sediment. Environmental Chemistry and Toxicology of Mercury, John Wiley & Sons, Inc.: 219-258.

  20. Ethnicity/culture modulates the relationships of the haptoglobin (Hp) 1-1 phenotype with cognitive function in older individuals with type 2 diabetes.

    Science.gov (United States)

    Guerrero-Berroa, Elizabeth; Ravona-Springer, Ramit; Heymann, Anthony; Schmeidler, James; Hoffman, Hadas; Preiss, Rachel; Koifmann, Keren; Greenbaum, Lior; Levy, Andrew; Silverman, Jeremy M; Leroith, Derek; Sano, Mary; Schnaider-Beeri, Michal

    2016-05-01

    The haptoglobin (Hp) genotype has been associated with cognitive function in type 2 diabetes. Because ethnicity/culture has been associated with both cognitive function and Hp genotype frequencies, we examined whether it modulates the association of Hp with cognitive function. This cross-sectional study evaluated 787 cognitively normal older individuals (>65 years of age) with type 2 diabetes participating in the Israel Diabetes and Cognitive Decline study. Interactions in two-way analyses of covariance compared Group (Non-Ashkenazi versus Ashkenazi Jews) on the associations of Hp phenotype (Hp 1-1 versus non- Hp 1-1) with five cognitive outcome measures. The primary control variables were age, gender, and education. Compared with Ashkenazi Jews, non-Ashkenazi Jews with the Hp 1-1 phenotype had significantly poorer cognitive function than non-Hp 1-1 in the domains of Attention/Working Memory (p = 0.035) and Executive Function (p = 0.023), but not in Language/Semantic Categorization (p = 0.432), Episodic Memory (p = 0.268), or Overall Cognition (p = 0.082). After controlling for additional covariates (type 2 diabetes-related characteristics, cardiovascular risk factors, Mini-mental State Examination, and extent of depressive symptoms), Attention/Working Memory (p = 0.038) and Executive Function (p = 0.013) remained significant. Older individuals from specific ethnic/cultural backgrounds with the Hp 1-1 phenotype may benefit more from treatment targeted at decreasing or halting the detrimental effects of Hp 1-1 on the brain. Future studies should examine differential associations of Hp 1-1 and cognitive impairment, especially for groups with high prevalence of both, such as African-Americans and Hispanics. Copyright © 2015 John Wiley & Sons, Ltd.

  1. Assessment of reproductive and developmental effects of DINP, DnHP and DCHP using quantitative weight of evidence.

    Science.gov (United States)

    Dekant, Wolfgang; Bridges, James

    2016-11-01

    Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores for quality and observed toxicity. This QWoE-methodology was applied to the reproductive toxicity data on diisononylphthalate (DINP), di-n-hexylphthalate (DnHP), and dicyclohexylphthalate (DCHP) to determine if the scientific evidence for adverse effects meets the requirements for classification as reproductive toxicants. The scores for DINP were compared to those when applying the methodology DCHP and DnHP that have harmonized classifications. Based on the quality/reliability scores, application of the QWoE shows that the three databases are of similar quality; but effect scores differ widely. Application of QWoE to DINP studies resulted in an overall score well below the benchmark required to trigger classification. For DCHP, the QWoE also results in low scores. The high scores from the application of the QWoE methodology to the toxicological data for DnHP represent clear evidence for adverse effects and justify a classification of DnHP as category 1B for both development and fertility. The conclusions on classification based on the QWoE are well supported using a narrative assessment of consistency and biological plausibility. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  2. LATE TRIASSIC OBLIQUE EXTRUSION OF UHP/HP COMPLEXES IN THE ATBASHI ACCRETIONARY COMPLEX OF SOUTH TIANSHAN, KYRGYZSTAN

    Directory of Open Access Journals (Sweden)

    Wenjiao Xiao

    2017-01-01

    Full Text Available The exhumation and tectonic emplacement of eclogites and blueschists take place in forearc accretionary complexes by either forearc- or backarc-directed extrusion, but few examples have been well analysed in detail. Here we present an example of oblique wedge extrusion of UHP/HP rocks in the Atbashi accretionary complex of the Kyrgyz South Tianshan.

  3. Optimization of statistical methods for HpGe gamma-ray spectrometer used in wide count rate ranges

    Energy Technology Data Exchange (ETDEWEB)

    Gervino, G., E-mail: gervino@to.infn.it [UNITO - Università di Torino, Dipartimento di Fisica, Turin (Italy); INFN - Istituto Nazionale di Fisica Nucleare, Sez. Torino, Turin (Italy); Mana, G. [INRIM - Istituto Nazionale di Ricerca Metrologica, Turin (Italy); Palmisano, C. [UNITO - Università di Torino, Dipartimento di Fisica, Turin (Italy); INRIM - Istituto Nazionale di Ricerca Metrologica, Turin (Italy)

    2016-07-11

    The need to perform γ-ray measurements with HpGe detectors is a common technique in many fields such as nuclear physics, radiochemistry, nuclear medicine and neutron activation analysis. The use of HpGe detectors is chosen in situations where isotope identification is needed because of their excellent resolution. Our challenge is to obtain the “best” spectroscopy data possible in every measurement situation. “Best” is a combination of statistical (number of counts) and spectral quality (peak, width and position) over a wide range of counting rates. In this framework, we applied Bayesian methods and the Ellipsoidal Nested Sampling (a multidimensional integration technique) to study the most likely distribution for the shape of HpGe spectra. In treating these experiments, the prior information suggests to model the likelihood function with a product of Poisson distributions. We present the efforts that have been done in order to optimize the statistical methods to HpGe detector outputs with the aim to evaluate to a better order of precision the detector efficiency, the absolute measured activity and the spectra background. Reaching a more precise knowledge of statistical and systematic uncertainties for the measured physical observables is the final goal of this research project.

  4. Finite element analysis of the Girkmann problem using the modern hp-version and the classical h-version

    KAUST Repository

    Niemi, Antti; Babuška, Ivo M.; Pitkä ranta, Juhani; Demkowicz, Leszek F.

    2011-01-01

    elasticity theory and (2) by using a dimensionally reduced shell-ring model. In the first approach the problem is solved with a fully automatic hp-adaptive finite element solver whereas the classical h-version of the finite element method is used

  5. Scoring the home falls and accidents screening tool for health professionals (HOME FAST-HP): Evidence from one epidemiological study.

    Science.gov (United States)

    Mackenzie, Lynette; Byles, Julie

    2018-03-30

    Falls in older people are a major public health concern. To target falls prevention interventions, screening tools need to be able to identify older people at greater risk of falling. This study aimed to investigate the screening capacity of the Home Falls and Accidents Screening Tool for health professionals (HOME FAST-HP), and to identify the best cut-off score to identify older people at higher risk of falls using the HOME FAST-HP. The study used cross-sectional data from a random sample of 650 women from the 1921 to 1926 cohort of the Australian Longitudinal Study of Women's Health (ALSWH). Selected women were sent a postal survey including the HOME FAST-HP, falls history, and other health factors. Scores on the home fast were calculated and the cut-point for optimal sensitivity and specificity of the HOME FAST-HP in relation to falls was assessed using a Receiver Operating Characteristic curve. A total of 567 older women participated (response rate 87%). The mean age of participants was 77.5 yrs (95% CI 77.31-77.70). A total of 153 participants (27%) reported a fall in the previous six months. The mean number of hazards using the HOME FAST-HP was 9.74 (95% CI 9.48-10.01), range 2-22. Non-fallers had a mean of 9.6 hazards (95% CI 9.32-9.91) and fallers had a mean of 10.63 hazards (95% CI 10.08-11.19) which was a significant difference (t = 3.41, P = 0.001). The area under the receiver operator curve (AUC) was 0.58 (95% CI 0.53-0.64). A HOME FAST-HP cut-off score of 9 was associated with the optimal sensitivity for falls (73.9%), with specificity (37.9%), and positive predictive value was 30.6% and negative predictive value was 79.7%. The HOME FAST-HP can be used as a screening tool to identify fallers with a cut-off score of nine indicating a higher risk of falling. © 2018 Occupational Therapy Australia.

  6. Negative-tone imaging with EUV exposure toward 13nm hp

    Science.gov (United States)

    Tsubaki, Hideaki; Nihashi, Wataru; Tsuchihashi, Toru; Yamamoto, Kei; Goto, Takahiro

    2016-03-01

    Negative-tone imaging (NTI) with EUV exposure has major advantages with respect to line-width roughness (LWR) and resolution due in part to polymer swelling and favorable dissolution mechanics. In NTI process, both resist and organic solvents play important roles in determining lithography performances. The present study describes novel chemically amplified resist materials based on NTI technology with EUV using a specific organic solvents. Lithographic performances of NTI process were described in this paper under exposures using ASML NXE:3300 EUV scanner at imec. It is emphasized that 14 nm hp was nicely resolved under exposure dose of 37 mJ/cm2 without any bridge and collapse, which are attributed to the low swelling character of NTI process. Although 13 nm hp resolution was potentially obtained, a pattern collapse still restricts its resolution in case coating resist film thickness is 40 nm. Dark mask limitation due mainly to mask defectivity issue makes NTI with EUV favorable approach for printing block mask to produce logic circuit. A good resolution of CD-X 21 nm/CD-Y 32 nm was obtained for block mask pattern using NTI with usable process window and dose of 49 mJ/cm2. Minimum resolution now reaches CD-X 17 nm / CD-Y 23 nm for the block. A 21 nm block mask resolution was not affected by exposure dose and explored toward low dose down to 18 mJ/cm2 by reducing quencher loading. In addition, there was a negligible amount of increase in LCDU for isolated dot pattern when decreasing exposure dose from 66 mJ/cm2 to 24 mJ/cm2. On the other hand, there appeared tradeoff relationship between LCDU and dose for dense dot pattern, indicating photon-shot noise restriction, but strong dependency on patterning features. Design to improve acid generation efficiency was described based on acid generation mechanism in traditional chemically amplified materials which contains photo-acid generator (PAG) and polymer. Conventional EUV absorber comprises of organic compounds is

  7. Effect of a long-chained fructan Raftiline HP on blood lipids and spontaneous atherosclerosis in low density receptor knockout mice

    DEFF Research Database (Denmark)

    Mortensen, Alicja; Poulsen, Morten; Frandsen, Henrik Lauritz

    2002-01-01

    The effect of a long-chained fructan Raftiline HP on spontaneous hypercholesterolemia and atherosclerosis was studied in 40 LDLR-/- male mice receiving isocaloric, balanced in fat content, purified diets with 0 or 10% Raftiline HP, for 16 weeks. The feed intake was comparable (3.9 v. 3.8 g/day) b...

  8. KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1

    Science.gov (United States)

    Borgel, Julie; Tyl, Marek; Schiller, Karin; Pusztai, Zsofia; Dooley, Christopher M.; Deng, Wen; Wooding, Carol; White, Richard J.; Warnecke, Tobias; Leonhardt, Heinrich; Busch-Nentwich, Elisabeth M.

    2017-01-01

    Abstract Functional genomic elements are marked by characteristic DNA and histone modification signatures. How combinatorial chromatin modification states are recognized by epigenetic reader proteins and how this is linked to their biological function is largely unknown. Here we provide a detailed molecular analysis of chromatin recognition by the lysine demethylase KDM2A. Using biochemical approaches we identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (HP1) interaction motif that mediates direct binding between KDM2A and HP1. This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals. The multivalent engagement with DNA and HP1 results in a nucleosome binding circuit in which KDM2A can be recruited to H3K9me3-modified chromatin through HP1, and HP1 can be recruited to unmodified chromatin by KDM2A. A KDM2A mutant deficient in HP1-binding is inactive in an in vivo overexpression assay in zebrafish embryos demonstrating that the HP1 interaction is essential for KDM2A function. Our results reveal a complex regulation of chromatin binding for both KDM2A and HP1 that is modulated by DNA- and H3K9-methylation, and suggest a direct role for KDM2A in chromatin silencing. PMID:28180290

  9. High pressure sintering (HP-HT) of diamond powders with titanium and titanium carbide

    International Nuclear Information System (INIS)

    Jaworska, L.

    1999-01-01

    Polycrystalline diamond compacts for cutting tools are mostly manufactured using high pressure sintering (HP-HT). The standard diamond compacts are prepared by diamond powders sintering with metallic binding phase. The first group of metallic binder are metals able to solve carbon - Co, Ni. The second group of metal binders are carbide forming elements - Ti, Cr, W and others. The paper describes high pressure sintering of diamond powder with titanium and nonstoichiometry titanium carbide for cutting tool application. A type of binding phase has the significant influence on microstructure and mechanical properties of diamond compacts. Very homogeneous structure was achieved in case of compacts obtained from metalized diamond where diamond-TiC-diamond connection were predominant. In the case of compacts prepared by mechanical mixing of diamond with titanium powders the obtained structure was nonhomogeneous with titanium carbide clusters. They had more diamond to diamond connections. These compacts compared to the compact made of metallized diamond have greater wear resistance. In the case of the diamond and TiC 0.92 sintering the strong bonding of TiC diamond grains was obtained. The microstructure observations for diamond with 5% wt. Ti and diamond with 5% wt. TiC 0.92 (the initial composition) compacts were performed in transmission microscope. For two type of compacts the strong bonding phase TiC without defects is creating. (author)

  10. Liquid-Hydrogen-Cooled 450-hp Electric Motor Test Stand Being Developed

    Science.gov (United States)

    Kascak, Albert F.; Trudell, Jeffrey J.; Brown, Gerald V.

    2005-01-01

    With growing concerns about global warming, there is a need to develop pollution-free aircraft. One approach is to use hydrogen-fueled aircraft that use fuel cells or turbogenerators to produce electric power to drive the electric motors that turn the aircraft s propulsive fans. Hydrogen fuel would be carried as a liquid, stored at its boiling point of 20.5 K (-422.5 F). Conventional electric motors, however, are too heavy for aircraft propulsion. We need to develop high-power, lightweight electric motors (highpower- density motors). One approach is to increase the conductivity of the wires by cooling them with liquid hydrogen (LH2). This would allow superconducting rotors with an ironless core. In addition, the motor could use very pure aluminum or copper, substances that have low resistances at cryogenic temperatures. A preliminary design of a 450-hp LH2-cooled electric motor was completed and is being manufactured by a contractor. This motor will be tested at the NASA Glenn Research Center and will be used to test different superconducting materials such as magnesium diboride (MgB2). The motor will be able to operate at speeds of up to 6000 rpm.

  11. New high pressure die cast magnesium alloy AM-HP2 for powertrain applications

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, M.A. [Queensland Univ., Brisbane (Australia). CAST CRC]|[CSIRO Manufacturing and Materials Technology, Clayton (Australia); Zhu, S.M.; Nie, J.F. [Queensland Univ., Brisbane (Australia). CAST CRC]|[Monash Univ., Monash (Australia). Dept. of Materials Engineering

    2007-07-01

    In order to improve the benefits available through weight savings on engine emissions, magnesium alloys must gain wider acceptance in transmission and engine applications. This paper provided details of a new alloy with exceptional creep properties developed for automotive powertrain applications. The AM-HP2 alloy was developed as part of a broader research program investigating the relationship between the composition, structure and properties of magnesium rare earth (Mg-RE) based alloys and high-pressure die casting (HPDC). Cylindrical test specimens of various alloys were produced on a cold chamber HPDC machine. Tensile creep tests were then conducted under a constant load at 177 degrees C for a period of 600 hours. Microstructures of specimens were characterized using a CM20 transmission electron microscope. Results of the tests indicated that near-grain boundary microstructure was an important parameter in securing optimum elevated temperature properties. The RE element had a significant effect on the creep behaviour of the HPDC Mg-RE alloys. It was concluded that further research is needed to investigate the influence of the RE mixture in improving creep performance. 15 refs., 2 tabs., 6 figs.

  12. Gr and hp-1 tomato mutants unveil unprecedented interactions between arbuscular mycorrhizal symbiosis and fruit ripening.

    Science.gov (United States)

    Chialva, Matteo; Zouari, Inès; Salvioli, Alessandra; Novero, Mara; Vrebalov, Julia; Giovannoni, James J; Bonfante, Paola

    2016-07-01

    Systemic responses to an arbuscular mycorrhizal fungus reveal opposite phenological patterns in two tomato ripening mutants depending whether ethylene or light reception is involved. The availability of tomato ripening mutants has revealed many aspects of the genetics behind fleshy fruit ripening, plant hormones and light signal reception. Since previous analyses revealed that arbuscular mycorrhizal symbiosis influences tomato berry ripening, we wanted to test the hypothesis that an interplay might occur between root symbiosis and fruit ripening. With this aim, we screened seven tomato mutants affected in the ripening process for their responsiveness to the arbuscular mycorrhizal fungus Funneliformis mosseae. Following their phenological responses we selected two mutants for a deeper analysis: Green ripe (Gr), deficient in fruit ethylene perception and high-pigment-1 (hp-1), displaying enhanced light signal perception throughout the plant. We investigated the putative interactions between ripening processes, mycorrhizal establishment and systemic effects using biochemical and gene expression tools. Our experiments showed that both mutants, notwithstanding a normal mycorrhizal phenotype at root level, exhibit altered arbuscule functionality. Furthermore, in contrast to wild type, mycorrhization did not lead to a higher phosphate concentration in berries of both mutants. These results suggest that the mutations considered interfere with arbuscular mycorrhiza inducing systemic changes in plant phenology and fruits metabolism. We hypothesize a cross talk mechanism between AM and ripening processes that involves genes related to ethylene and light signaling.

  13. Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl.

    Science.gov (United States)

    Wragg, David; Mwacharo, Joram M; Alcalde, José A; Wang, Chen; Han, Jian-Lin; Gongora, Jaime; Gourichon, David; Tixier-Boichard, Michèle; Hanotte, Olivier

    2013-01-01

    Oocyan or blue/green eggshell colour is an autosomal dominant trait found in native chickens (Mapuche fowl) of Chile and in some of their descendants in European and North American modern breeds. We report here the identification of an endogenous avian retroviral (EAV-HP) insertion in oocyan Mapuche fowl and European breeds. Sequencing data reveals 100% retroviral identity between the Mapuche and European insertions. Quantitative real-time PCR analysis of European oocyan chicken indicates over-expression of the SLCO1B3 gene (P<0.05) in the shell gland and oviduct. Predicted transcription factor binding sites in the long terminal repeats (LTR) indicate AhR/Ar, a modulator of oestrogen, as a possible promoter/enhancer leading to reproductive tissue-specific over-expression of the SLCO1B3 gene. Analysis of all jungle fowl species Gallus sp. supports the retroviral insertion to be a post-domestication event, while identical LTR sequences within domestic chickens are in agreement with a recent de novo mutation.

  14. The Effect of Replacing Fish Meal in the Diet with Enzyme-Treated Soybean Meal (HP310) on Growth and Body Composition of Rainbow Trout Fry.

    Science.gov (United States)

    Haghbayan, Samira; Shamsaie Mehrgan, Mehdi

    2015-11-26

    The potential of enzyme-treated soybean meal powder (HP310) as fish meal alternative in diets for rainbow trout weighing 1.17 ± 0.3 g was evaluated for 60 days. Fish meal was replaced with HP310 at 25%, 50%, 75% and 100% of experimental diets. A control group was also considered. The results showed that diets containing 75% and 100% HP310 had significantly higher feed conversion ratio and lower feed intake, weight gain and specific growth rate compared to fish feed diets containing higher levels of fish protein ingredients (p replacement levels of diet (p > 0.05). However increasing in level of HP310 in the diet caused a significant increase of the white blood cells (p replaced by HP310 showed the highest values of ash and moisture content among the diets and showed significantly different levels when compared with the control and other feeding treatments (p < 0.05).

  15. Evaluation des fluides de forage HP/HT pour forages profonds Evaluation of Hp/Ht Drilling Fluid Formulations for Deep Drilling

    Directory of Open Access Journals (Sweden)

    Argillier J. F.

    2006-11-01

    Full Text Available Le forage de puits profonds exige la mise au point de fluides de forage dont la formulation est adaptée aux températures élevées de formation : l'une des principales difficultés est la dégradation thermique des additifs chimiques utilisés dans les formulations à base d'eau qui se produit fréquemment lors du forage de puits à température élevée. Cette dégradation peut conduire à des variations importantes des caractéristiques rhéologiques et de filtration et à une perte de propriétés nécessaires à leur performance. De plus, même s'il n'y a pas de dégradation des composants la viscosité des solutions de polymères hydrosolubles couramment utilisés dans les formulations de fluides diminue fortement avec l'augmentation de la température au-dessus de 60°C. Une autre source de difficulté qui apparaît à forte température avec les boues à base d'eau est la gélification des argiles utilisées dans la formulation. Ce phénomène provoque une forte augmentation de la viscosité de la formulation et des pertes de charges, en particulier en cas de reprise de forage. Diverses méthodes ont été mises au point pour étudier le comportement des boues à base d'eau dans des conditions de pression et de température élevées, entre autres : - des expériences de laboratoire, pour étudier par exemple la stabilité en conditions anaérobies des solutions de polymères et le comportement rhéologique des suspensions d'argile dans des conditions de pression et de température élevées afin de simuler les caractéristiques de gélification des argiles à haute température; - des essais sur boucle d'étude HP/HT en utilisant une boucle expérimentale conçue pour étudier les fluides de forage dans des conditions de fond réalistes, c'est-à-dire des températures atteignant 180°C, des pressions atteignant 500 bar et des taux de cisaillement atteignant 10 000 s puissance( -1 Cette méthodologie a permis d'étudier un certain

  16. Functional and evolutionary analyses of Helicobacter pylori HP0231 (DsbK protein with strong oxidative and chaperone activity characterized by a highly diverged dimerization domain

    Directory of Open Access Journals (Sweden)

    Katarzyna Marta Bocian-Ostrzycka

    2015-10-01

    Full Text Available Helicobacter pylori does not encode the classical DsbA/DsbB oxidoreductases that are crucial for oxidative folding of extracytoplasmic proteins. Instead, this microorganism encodes an untypical two proteins playing a role in disulfide bond formation – periplasmic HP0231, which structure resembles that of EcDsbC/DsbG, and its redox partner, a membrane protein HpDsbI (HP0595 with a -propeller structure. The aim of presented work was to assess relations between HP0231 structure and function.We showed that HP0231 is most closely related evolutionarily to the catalytic domain of DsbG, even though it possesses a catalytic motif typical for canonical DsbA proteins. Similarly, the highly diverged N-terminal dimerization domain is homologous to the dimerization domain of DsbG. To better understand the functioning of this atypical oxidoreductase, we examined its activity using in vivo and in vitro experiments. We found that HP0231 exhibits oxidizing and chaperone activities but no isomerizing activity, even though H. pylori does not contain a classical DsbC. We also show that HP0231 is not involved in the introduction of disulfide bonds into HcpC (Helicobacter cysteine-rich protein C, a protein involved in the modulation of the H. pylori interaction with its host. Additionally, we also constructed a truncated version of HP0231 lacking the dimerization domain, denoted HP0231m, and showed that it acts in E. coli cells in a DsbB-dependent manner. In contrast, HP0231m and classical monomeric EcDsbA (Escherichia coli DsbA protein were both unable to complement the lack of HP0231 in H. pylori cells, though they exist in oxidized forms. HP0231m is inactive in the insulin reduction assay and possesses high chaperone activity, in contrast to EcDsbA. In conclusion, HP0231 combines oxidative functions characteristic of DsbA proteins and chaperone activity characteristic of DsbC/DsbG, and it lacks isomerization activity.

  17. Correlation between Chinese and international energy prices based on a HP filter and time difference analysis

    International Nuclear Information System (INIS)

    He, Yongxiu; Wang, Bing; Wang, Jianhui; Xiong, Wei; Xia, Tian

    2013-01-01

    To establish a reasonable system and mechanism for Chinese energy prices, we use the Granger causality test, Hodrick–Prescott (HP) filter and time difference analysis to research the pricing relationship between Chinese and international energy prices. We find that Chinese and international crude oil prices changed synchronously while Chinese refined oil prices follow the changes of international oil prices with the time difference being about 1 month to 2 months. Further, Australian coal prices Granger causes Chinese coal prices, and there is a high correlation between them. The U.S. electricity price is influenced by the WTI crude oil price, the U.S. gasoline price and the HenryHub gas price. Due to the unreasonable price-setting mechanism and regulation from the central government, China′s terminal market prices for both electricity and natural gas do not reflect the real supply–demand situation. This paper provides quantitative results on the correlation between Chinese and international energy prices to better predict the impact of international energy price fluctuations on China′s domestic energy supply and guide the design of more efficient energy pricing policies. Moreover, it provides references for developing countries to improve their energy market systems and trading, and to coordinate domestic and international energy markets. -- Highlights: •The Hodrick-Prescott filter and time difference analysis are used to research the correlation among energy prices. •Our study finds that the U.S. and British refined oil prices Granger cause the Chinese refined oil price. •Both Chinese and the Australian coal prices play an important role in the international coal market. •The Chinese terminal electric power and terminal natural gas prices are not highly correlated. •The results are useful for guiding the design of more efficient energy pricing policies in China

  18. Dual photon absorptiometer utilizing a HpGe detector and microprocessor controller

    International Nuclear Information System (INIS)

    Ellis, K.J.; Vartsky, D.; Pearlstein, T.B.; Alberi, J.L.; Cohn, S.H.

    1978-01-01

    The analysis of bone mineral content (BMC) using a single energy-photon beam assumes that there are only two materials present, bone mineral and a uniform soft tissue component. Uncertainty in the value of BMC increases with different adipose tissue components in the transmitted beam. These errors, however, are reduced by the dual energy technique. Also, extension to additional energies further identifies the separate constituents of the soft tissue component. A multi-energy bone scanning apparatus with data acquisition and analysis capability sufficient to perform multi-energy analysis of bone mineral content was designed and developed. The present work reports on the development of device operated in the dual energy mode. The high purity germanium (HpGe) detector is an integral component of the scanner. Errors in BMC due to multiple small angle scatters are reduced due to the excellent energy resolution of the detector (530 eV at 60 keV). Also, the need to filter the source or additional collimation on the detector is eliminated. A new dual source holder was designed using 200 mCi 125 I and 100 mCi 241 Am. The active areas of the two source capsules are aligned on a common axis. The congruence of the dual source was verified by measuring the collimator response function. This new holder design insures that the same tissue mass simultaneously attenuates both sources. The controller portion of the microprocessor allows for variation in total scan length, step size, and counting time per step. These options allow for multiple measurements without changes in the detector, source, or collimator. The system has been successfully used to determine the BMC content of different bones

  19. Age and duration of eclogite-facies metamorphism, North Qaidam HP/UHP terrane, Western China

    Science.gov (United States)

    Mattinson, C.G.; Wooden, J.L.; Liou, J.G.; Bird, D.K.; Wu, C.L.

    2006-01-01

    Amphibolite-facies para-and orthogneisses near Dulan, at the southeast end of the North Qaidam terrane, enclose minor eclogite and peridotite which record ultra-high pressure (UHP) metamorphism associated with the Early Paleozoic continental collision of the Qilian and Qaidam microplates. Field relations and coesite inclusions in zircons from paragneiss suggest that felsic, mafic, and ultramafic rocks all experienced UHP metamorphism and a common amphibolite-facies retrogression. SHRIMP-RG U-Pb and REE analyses of zircons from four eclogites yield weighted mean ages of 449 to 422 Ma, and REE patterns (flat HREE, no Eu anomaly) and inclusions of garnet, omphacite, and rutile indicate these ages record eclogite-facies metamorphism. The coherent field relations of these samples, and the similar range of individual ages in each sample suggests that the ???25 m.y. age range reflects the duration of eclogite-facies conditions in the studied samples. Analyses from zircon cores in one sample yield scattered 433 to 474 Ma ages, reflecting partial overlap on rims, and constrain the minimum age of eclogite protolith crystallization. Inclusions of Th + REE-rich epidote, and zircon REE patterns are consistent with prograde metamorphic growth. In the Lu??liang Shan, approximately 350 km northwest in the North Qaidam terrane, ages interpreted to record eclogite-facies metamorphism of eclogite and garnet peridotite are as old as 495 Ma and as young as 414 Ma, which suggests that processes responsible for extended high-pressure residence are not restricted to the Dulan region. Evidence of prolonged eclogite-facies metamorphism in HP/UHP localities in the Northeast Greenland eclogite province, the Western Gneiss Region of Norway, and the western Alps suggests that long eclogite-facies residence may be globally significant in continental subduction/collision zones.

  20. Discrete Maximum Principle for a 1D Problem with Piecewise-Constant Coefficients Solved by hp-FEM

    Czech Academy of Sciences Publication Activity Database

    Vejchodský, Tomáš; Šolín, Pavel

    2007-01-01

    Roč. 15, č. 3 (2007), s. 233-243 ISSN 1570-2820 R&D Projects: GA ČR GP201/04/P021; GA ČR GA102/05/0629 Institutional research plan: CEZ:AV0Z10190503; CEZ:AV0Z20570509 Keywords : discrete maximum principle * hp-FEM * Poisson equation Subject RIV: BA - General Mathematics

  1. Space and Time Adaptive Two-Mesh hp-Finite Element Method for Transient Microwave Heating Problems

    Czech Academy of Sciences Publication Activity Database

    Dubcová, Lenka; Šolín, Pavel; Červený, Jakub; Kůs, Pavel

    1-2, č. 30 (2010), s. 23-40 ISSN 0272-6343 R&D Projects: GA ČR(CZ) GA102/07/0496; GA AV ČR IAA100760702 Institutional research plan: CEZ:AV0Z20570509 Keywords : hp-finite element method * microwave heating * edge elements Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.844, year: 2010

  2. Quantitative kinetics of In-111 autologous (In-AP) and homologous (Cr-HP) platelets in immune thrombocytopenic purpura (ITP)

    International Nuclear Information System (INIS)

    Lotter, M.G.; Heyns, A.D.P.; Badenhorst, P.N.; Minnaar, P.C.

    1984-01-01

    Contrary to the accepted view, the authors have found that platelet turnover is not always increased in ITP if the mean platelet survival time (PS) is measured with In-AP. The authors investigated the possible cause of the discrepancy by comparing kinetics of In-AP with those of Cr-HP in 10 patients with ITP. PS was estimated with the multiple hit model. The equilibrium and final in vivo distribution of In-AP was quantitated with the geometrical mean method. The patients could be divided into either those with splenic or diffuse RES platelet destruction. The authors conclude that in ITP platelet survival of In-AP is significantly (P < .05) longer than that of Cr-HP. Platelet turnover measured with In-AP is only normal in patients with mainly splenic platelet sequestration. Results with Cr-HP give a false impression of PS. It seems that in ITP those patients with severe disease also have a platelet production defect

  3. A comparative study of stool antigen Immunocard STAT HpSA test with biopsy in diagnosis of H Pylori Infection

    Directory of Open Access Journals (Sweden)

    Munish Rastogi

    2015-12-01

    Full Text Available The present study was conducted on 78 cases in the Department of Medicine at G.S.V.M Medical College, Kanpur who reported with various gastrointestinal symptoms such as dyspepsia, heartburns, nausea, vomiting and loss of appetite. They all were advised for biopsy by the physician. Patients treated with antibiotics, bismuth or proton pump inhibitors within 4 weeks preceding the study were excluded. Invasive tests using mucosal biopsies including histology and rapid urease test (RUT were used to establish the gold standard in order to evaluate the accuracy of Immunocard STAT HpSA. Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value of Immunocard STAT HpSA as compared to gold standard were 95.5%, 81.8%, 96.9% and 75.0% respectively. It is thus concluded that the Immunocard STAT HpSA test has a diagnostic value comparable to the gold standard in detecting H Pylori. The sensitivity and specificity of the test is fair enough to be used as a test for screening purpose and also for diagnosis and treatment of H.Pylori infection in clinical practice

  4. The cag PAI is intact and functional but HP0521 varies significantly in Helicobacter pylori isolates from Malaysia and Singapore.

    Science.gov (United States)

    Schmidt, H-M A; Andres, S; Nilsson, C; Kovach, Z; Kaakoush, N O; Engstrand, L; Goh, K-L; Fock, K M; Forman, D; Mitchell, H

    2010-04-01

    Helicobacter pylori-related disease is at least partially attributable to the genotype of the infecting strain, particularly the presence of specific virulence factors. We investigated the prevalence of a novel combination of H. pylori virulence factors, including the cag pathogenicity island (PAI), and their association with severe disease in isolates from the three major ethnicities in Malaysia and Singapore, and evaluated whether the cag PAI was intact and functional in vitro. Polymerase chain reaction (PCR) was used to detect dupA, cagA, cagE, cagT, cagL and babA, and to type vacA, the EPIYA motifs, HP0521 alleles and oipA ON status in 159 H. pylori clinical isolates. Twenty-two strains were investigated for IL-8 induction and CagA translocation in vitro. The prevalence of cagA, cagE, cagL, cagT, babA, oipA ON and vacA s1 and i1 was >85%, irrespective of the disease state or ethnicity. The prevalence of dupA and the predominant HP0521 allele and EPIYA motif varied significantly with ethnicity (p < 0.05). A high prevalence of an intact cag PAI was found in all ethnic groups; however, no association was observed between any virulence factor and disease state. The novel association between the HP0521 alleles, EPIYA motifs and host ethnicity indicates that further studies to determine the function of this gene are important.

  5. Recent advances with quiescent power supply current (I(sub DDQ)) testing at Sandia using the HP82000

    Science.gov (United States)

    Righter, A. W.; Leong, D. J.; Cox, L. B.

    Last year at the HP82000 Users Group Meeting, Sandia National Laboratories gave a presentation on I(sub DDQ) testing. This year, some advances are presented on this testing including DUT board fixturing, external DC PMU measurement, and automatic IDD-All circuit calibration. Implementation is examined more than theory, with results presented from Sandia tests. After a brief summary I(sub DDQ) theory and testing concepts, how the break (hold state) vector and data formatting present a test vector generation concern for the HP82000 is described. Fixturing of the DUT board for both types of I(sub DDQ) measurement is then discussed, along with how the continuity test and test vector generation must be taken into account. Results of a test including continuity, IDD-All and I(sub DDQ) Value measurements is shown. Next, measurement of low current using an external PMU is discussed, including noise considerations, implementation and some test results showing nA-range measurements. A method is presented for automatic calibration of the IDD-All analog comparator circuit using RM BASIC on the HP82000, with implementation and measurement results. Finally, future directions for research in this area is explored.

  6. Cumulative nucleon production in 3Hep- and 3Hp interactions at momenta of colliding nuclei 5 GeV/c

    International Nuclear Information System (INIS)

    Abdullin, S.K.; Blinov, A.V.; Vanyushin, I.A.

    1989-01-01

    Inclusive cross sections of cumulative protons produced in 3 Hep- and 3 Hp-interactions under momenta of colliding 5 GeV/c nuclei are investigated. Experimental material is obtained using liquid-hydrogen ITEP chamber-80cm. Under the cumulative proton kinetic energy, exceeding 50 MeV inclusive cross section ratio σ( 3 Hep→pX)/σ( 3 Hp→pX)=1.6±0.1. Within the same energy interval evaluation of yield ratio of cumulative protons and neutrons, produced in 3 Hep -interactions, leads to ∼ 1.6 value. Asymmetry of mean multiple protons escaping forward and backward both in 3 Hep -and in 3 Hp interactions is observed. Averaged invariant distribution functions for cumulative protons and neutrons in 8 Hep-interactions and protons in 3 Hp-interactions are constructed (the averaging is performed within 90-180 deg and 120-180 deg intervals). To temperatures of such distributions are found. 43 refs.; 1 fig

  7. Comparing Hp(3) evaluated from the conversion coefficients from air kerma to personal dose equivalent for eye lens dosimetry calibrated on a new cylindrical PMMA phantom

    Science.gov (United States)

    Esor, J.; Sudchai, W.; Monthonwattana, S.; Pungkun, V.; Intang, A.

    2017-06-01

    Based on a new occupational dose limit recommended by ICRP (2011), the annual dose limit for the lens of the eye for workers should be reduced from 150 mSv/y to 20 mSv/y averaged over 5 consecutive years in which no single year exceeding 50 mSv. This new dose limit directly affects radiologists and cardiologists whose work involves high radiation exposure over 20 mSv/y. Eye lens dosimetry (Hp(3)) has become increasingly important and should be evaluated directly based on dosimeters that are worn closely to the eye. Normally, Hp(3) dose algorithm was carried out by the combination of Hp(0.07) and Hp(10) values while dosimeters were calibrated on slab PMMA phantom. Recently, there were three reports from European Union that have shown the conversion coefficients from air kerma to Hp(3). These conversion coefficients carried out by ORAMED, PTB and CEA Saclay projects were performed by using a new cylindrical head phantom. In this study, various delivered doses were calculated using those three conversion coefficients while nanoDot, small OSL dosimeters, were used for Hp(3) measurement. These calibrations were performed with a standard X-ray generator at Secondary Standard Dosimetry Laboratory (SSDL). Delivered doses (Hp(3)) using those three conversion coefficients were compared with Hp(3) from nanoDot measurements. The results showed that percentage differences between delivered doses evaluated from the conversion coefficient of each project and Hp(3) doses evaluated from the nanoDots were found to be not exceeding -11.48 %, -8.85 % and -8.85 % for ORAMED, PTB and CEA Saclay project, respectively.

  8. Progression of Emphysema Evaluated by MRI Using Hyperpolarized 3He (HP 3He Measurements in Patients with Alpha-1-Antitrypsin (A1AT) Deficiency Compared with CT and Lung Function Tests

    International Nuclear Information System (INIS)

    Stavngaard, T.; Vejby Soegaard, L.; Batz, M.; Schreiber, L.M.; Dirksen, A.

    2009-01-01

    Background: The progression of emphysema is traditionally measured by pulmonary function test, with forced expiratory volume in 1 s (FEV1) being the most accepted and used measurement. However, FEV1 is insensitive in detecting mild/slow progression of emphysema because of low reproducibility as compared to yearly decline. Purpose: To investigate the progression of emphysema over a period of 2 years using diffusion-weighted hyperpolarized (HP) 3 He magnetic resonance imaging (MRI) in patients with alpha-1-antitrypsin (A1AT) deficiency. Material and Methods: Nine patients with severe A1AT deficiency were studied over a period of 2 years (baseline, year 1, and year 2) with HP 3 He MRI using apparent diffusion coefficient (ADC), lung function tests (FEV1 and carbon monoxide lung diffusion capacity [DL,CO]), and computed tomography (CT) using densitometric parameters (15th percentile density [CT-PD15] and relative area of emphysema below -910 HU [CT-RA-910]). Results: Seven patients were scanned three times, one patient two times, and one patient only at baseline. The mean increase in ADC values from first to last HP 3 He MR scanning was 3.8% (0.014 cm 2 /s [SD 0.024 cm 2 /s]; not significant). The time trends for FEV1, DL,CO, CT-PD15, and CT-RA-910 were all statistically significant. We found a high correlation between ADC and DL,CO (P 3 He MRI for monitoring the progression of emphysema. However, in the future, larger studies are needed to confirm these preliminary results

  9. Dynamic variation of histone H3 trimethyl Lys4 (H3K4me3) and heterochromatin protein 1 (HP1) with employment length in nickel smelting workers.

    Science.gov (United States)

    Zhao, Yanhong; Cheng, Ning; Dai, Min; Pu, Hongquan; Zheng, Tongzhang; Li, Haiyan; He, Jie; Bai, Yana

    2017-07-01

    To investigate the dynamic variation in H3K4me3 and HP1 with employment length in nickel smelting workers. Blood samples were collected from 140 nickel smelting workers and 140 age-matched office workers to test for H3K4me3, and HP1 levels. H3K4me3 was statistically significantly different (p exposure to nickel can induce oxidative damage, and increase H3K4me3 expression and inhibit HP1 expression.

  10. Flow development through HP & LP turbines, Part II: Effects of the hub endwall secondary sealing air flow on the turbine's mainstream flow

    Science.gov (United States)

    Hu, Jialin; Du, Qiang; Liu, Jun; Wang, Pei; Liu, Guang; Liu, Hongrui; Du, Meimei

    2017-08-01

    Although many literatures have been focused on the underneath flow and loss mechanism, very few experiments and simulations have been done under the engines' representative working conditions or considering the real cavity structure as a whole. This paper aims at realizing the goal of design of efficient turbine and scrutinizing the velocity distribution in the vicinity of the rim seal. With the aid of numerical method, a numerical model describing the flow pattern both in the purge flow spot and within the mainstream flow path is established, fluid migration and its accompanied flow mechanism within the realistic cavity structure (with rim seal structure and considering mainstream & secondary air flow's interaction) is used to evaluate both the flow pattern and the underneath flow mechanism within the inward rotating cavity. Meanwhile, the underneath flow and loss mechanism are also studied in the current paper. The computational results show that the sealing air flow's ingestion and ejection are highly interwound with each other in both upstream and downstream flow of the rim seal. Both the down-stream blades' potential effects as well as the upstream blades' wake trajectory can bring about the ingestion of the hot gas flow within the cavity, abrupt increase of the static pressure is believed to be the main reason. Also, the results indicate that sealing air flow ejected through the rear cavity will cause unexpected loss near the outlet section of the blades in the downstream of the HP rotor passages.

  11. Design of small diameter HT/HP sour service reeled rigid pipelines

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Daniel; Gouveia, Joao; Tardelli, Luciano [Tecnitas, Rio de Janeiro, RJ (Brazil)], e-mail: daniel.carneiro@br.bureauveritas.com; Parrilha, Rafael [Bureau Veritas Group, London (United Kingdom); Oazen, Eduardo; Cardoso, Carlos [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

    2009-12-19

    The paper presents an overview of the challenges overcome in the engineering design of two 219 mm diameter, 6 km length oil production pipelines, to be installed by reeling at Espirito Santo Basin, offshore Brazilian coast in 1500 m water depth. The high temperature and high pressure (HT/HP) operating conditions and sour content associated with the small diameter required to single well oil production would usually lead to flexible flow line solution in Brazilian fields. The decision of employing small diameter thick-walled rigid C-Mn steel pipelines with thick thermal insulation made necessary extensive engineering work to achieve a safe and robust thermal expansion control arrangement, including the design of walking mitigation and buckle initiation apparatus; a feasible weld acceptance criterion covering both high cycle fatigue due to pipe lay and vortex induced vibration (VIV) at free spans, and high strain low cycle fatigue and fracture growth induced by reeling installation and in-service lateral buckling. Several studies were performed using highly non-linear three-dimensional finite element models considering: pipe-soil interaction with full 3D seabed bathymetry; load history maintained from pipe lay to operational cycles, including temperature transient effects; high plastic strains (including steel properties de-rating due to high temperature) and section ovalization; mechanical contact between pipe and appurtenances during both installation and operational phases. Pipe-soil interaction comprised embedment considering dynamic effects of pipe lay and full non-linear lateral and axial response curves including break-out and residual resistance. Strain concentration factors due to field joints were evaluated using detailed solid models considering non-linear response of both steel and insulation materials. Susceptibility to VIV at free spans was assessed considering post loaded deformed span natural frequencies, including multi-span interaction effects and

  12. Fate of Subducting Organic Carbon: Evidence from HP/UHP Metasedimentary Suites

    Science.gov (United States)

    Kraft, K.; Bebout, G. E.

    2017-12-01

    Community interest in deep-Earth C cycling has focused attention on extents of C release from subducting oceanic lithosphere and sediment and the fate of this released C. Many have suggested that, based on isotopic and other arguments, 20% of the C subducted into the deeper mantle is in reduced form (organic); however, individual margins show large variation in carbonate to organic C ratios. Despite the size of the potentially deeply subducted organic C reservoir, its fate in subducting sections remains largely unexplored, with most attention paid to release of carbonate C. To characterize the forearc behavior of organic C, metamorphosed to P-T as high as that beneath volcanic fronts, we evaluated records of reduced C (RC) contents and isotope compositions in HP/UHP metasediments: 1) Schistes Lustres/Cignana (SLC) suite (Alps; Cook-Kollars et al., 2014, Chem Geol) with abundant carbonate and resembling sediment entering the East Sunda trench; and (2) Franciscan Complex (FC), W. Baja Terrain (WBT), Catalina Schist (CS) metasediments (Sadofsky and Bebout, 2003, G3), largely sandstone-shale sequences containing very little carbonate. In general, more Al-rich samples (shaley) in the terrigenous metasedimentary suites have higher concentrations of RC, which in low-grade units preserves δ13C of its organic protoliths. Carbonate-poor rocks in the SLC suite, and at ODP Site 765, show correlated major element (Al, Mg, Mn, Ti, P) and RC contents (up to 1.2 wt.%) reflecting sandstone-shale mixture. In the FC, WBT, and CS, the more Al-rich samples contain up to 2 wt. % RC. In high-grade Catalina Schist, RC has elevated δ13C due to C loss in CH4 and high-grade Alps rocks show reduced RC wt. % normalized to Al content. We consider processes that could alter contents and isotopic compositions of RC in sediment, e.g., devolatilization, closed-system exchange with carbonate, redox reactions, isotopic exchange with C in externally-derived fluids. It appears that, on modern Earth

  13. Structural, Mechanical, Anisotropic, and Thermal Properties of AlAs in oC12 and hP6 Phases under Pressure

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2018-05-01

    Full Text Available The structural, mechanical, anisotropic, and thermal properties of oC12-AlAs and hP6-AlAs under pressure have been investigated by employing first-principles calculations based on density functional theory. The elastic constants, bulk modulus, shear modulus, Young’s modulus, B/G ratio, and Poisson’s ratio for oC12-AlAs and hP6-AlAs have been systematically investigated. The results show that oC12-AlAs and hP6-AlAs are mechanically stable within the considered pressure. Through the study of lattice constants (a, b, and c with pressure, we find that the incompressibility of oC12-AlAs and hP6-AlAs is the largest along the c-axis. At 0 GPa, the bulk modulus B of oC12-AlAs, hP6-AlAs, and diamond-AlAs are 76 GPa, 75 GPa, and 74 Gpa, respectively, indicating that oC12-AlAs and hP6-AlAs have a better capability of resistance to volume than diamond-AlAs. The pressure of transition from brittleness to ductility for oC12-AlAs and hP6-AlAs are 1.21 GPa and 2.11 GPa, respectively. The anisotropy of Young’s modulus shows that oC12-AlAs and hP6-AlAs have greater isotropy than diamond-AlAs. To obtain the thermodynamic properties of oC12-AlAs and hP6-AlAs, the sound velocities, Debye temperature, and minimum thermal conductivity at considered pressure were investigated systematically. At ambient pressure, oC12-AlAs (463 K and hP6-AlAs (471 K have a higher Debye temperature than diamond-AlAs (433 K. At T = 300 K, hP6-AlAs (0.822 W/cm·K−1 has the best thermal conductivity of the three phases, and oC12-AlAs (0.809 W/cm·K−1 is much close to diamond-AlAs (0.813 W/cm·K−1.

  14. Heterochromatin protein 1 (HP1a positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila.

    Directory of Open Access Journals (Sweden)

    Lucia Piacentini

    2009-10-01

    Full Text Available Heterochromatin Protein 1 (HP1a is a well-known conserved protein involved in heterochromatin formation and gene silencing in different species including humans. A general model has been proposed for heterochromatin formation and epigenetic gene silencing in different species that implies an essential role for HP1a. According to the model, histone methyltransferase enzymes (HMTases methylate the histone H3 at lysine 9 (H3K9me, creating selective binding sites for itself and the chromodomain of HP1a. This complex is thought to form a higher order chromatin state that represses gene activity. It has also been found that HP1a plays a role in telomere capping. Surprisingly, recent studies have shown that HP1a is present at many euchromatic sites along polytene chromosomes of Drosophila melanogaster, including the developmental and heat-shock-induced puffs, and that this protein can be removed from these sites by in vivo RNase treatment, thus suggesting an association of HP1a with the transcripts of many active genes. To test this suggestion, we performed an extensive screening by RIP-chip assay (RNA-immunoprecipitation on microarrays, and we found that HP1a is associated with transcripts of more than one hundred euchromatic genes. An expression analysis in HP1a mutants shows that HP1a is required for positive regulation of these genes. Cytogenetic and molecular assays show that HP1a also interacts with the well known proteins DDP1, HRB87F, and PEP, which belong to different classes of heterogeneous nuclear ribonucleoproteins (hnRNPs involved in RNA processing. Surprisingly, we found that all these hnRNP proteins also bind heterochromatin and are dominant suppressors of position effect variegation. Together, our data show novel and unexpected functions for HP1a and hnRNPs proteins. All these proteins are in fact involved both in RNA transcript processing and in heterochromatin formation. This suggests that, in general, similar epigenetic mechanisms

  15. THE EFFECTS OF DIFFERENT K2HP04 AND NaCl LEVELS ON THE WATER-HOLDING CAPACITY AND COOKING LOSS OF GOAT MEAT

    Directory of Open Access Journals (Sweden)

    Mustafa Karakaya

    1996-01-01

    Full Text Available This research was conducted on the laboratory conditions. Different levels of K2HP04 (0.00%, 0.25%, 0.30% and NaCl (2.5%, 3.0% were applied on the goat meat and the pH, water holding capacity and cooking loss were observed. According to the results the effects of 0.25% K2HP04 addition was found statistically insignificant (p

  16. Helicobacter pylori protein HP0986 (TieA) interacts with mouse TNFR1 and triggers proinflammatory and proapoptotic signaling pathways in cultured macrophage cells (RAW 264.7).

    Science.gov (United States)

    Ansari, Suhail A; Devi, Savita; Tenguria, Shivendra; Kumar, Ashutosh; Ahmed, Niyaz

    2014-08-01

    HP0986 protein of Helicobacter pylori has been shown to trigger induction of proinflammatory cytokines (IL-8 and TNF-α) through the activation of NF-κB and also to induce Fas mediated apoptosis of human macrophage cells (THP-1). In this study, we unravel mechanistic details of the biological effects of this protein in a murine macrophage environment. Up regulation of MCP-1 and TNF-α in HP0986-induced RAW 264.7 cells occurred subsequent to the activation and translocation of NF-κB to the cell nucleus. Further, HP0986 induced apoptosis of RAW 264.7 cells through Fas activation and this was in agreement with previous observations made with THP-1 cells. Our studies indicated activation of TNFR1 through interaction with HP0986 and this elicited the aforementioned responses independent of TLR2, TLR4 or TNFR2. We found that mouse TNFR1 activation by HP0986 facilitates formation of a complex comprising of TNFR1, TRADD and TRAF2, and this occurs upstream of NF-κB activation. Furthermore, FADD also forms a second complex, at a later stage, together with TNFR1 and TRADD, resulting in caspase-8 activation and thereby the apoptosis of RAW 264.7 cells. In summary, our observations reveal finer details of the functional activity of HP0986 protein in relation to its behavior in a murine macrophage cell environment. These findings reconfirm the proinflammatory and apoptotic role of HP0986 signifying it to be an important trigger of innate responses. These observations form much needed baseline data entailing future in vivo studies of the functions of HP0986 in a murine model. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. PNNL supercomputer to become largest computing resource on the Grid

    CERN Multimedia

    2002-01-01

    Hewlett Packard announced that the US DOE Pacific Northwest National Laboratory will connect a 9.3-teraflop HP supercomputer to the DOE Science Grid. This will be the largest supercomputer attached to a computer grid anywhere in the world (1 page).

  18. Measurement of the tensor analyzing powers in the dd→3Hen and dd→3Hp reactions at RIKEN

    International Nuclear Information System (INIS)

    Ladygin, V.P.; Ladygina, N.B; Sakai, H.; Uesaka, T.

    2000-01-01

    A new experiment is proposed to measure the angular distribution of the tensor analyzing powers A yy , A xx , and A xz in the dd→ 3 Hen and dd→ 3 Hp reactions using polarized deuteron beam at RIKEN. These polarization observables are sensitive to the spin-momentum distribution of neutron (proton) in 3 He( 3 H) at short distances in the framework of one-nucleon exchange approximation. These measurements will provide new insight into the 3-nucleon system spin structure at distances unreachable at the moment using electromagnetic probes

  19. Execution of a cooperative test by means of 'in-situ-gamma spectrometry' using HP-germanium detectors

    International Nuclear Information System (INIS)

    Steger, F.; Lovranich, E.; Urbanich, E.; Streit, S.

    1995-06-01

    A cooperative test was carried out in Salzburg, Austria, in order to determine the activity of Cs-137 and other radio nuclides from the Tschernobyl fallout 1986 and from tests of nuclear weapons in the 1960s. 24 groups from 9 countries of Europe took part. The measurements were performed by means of gamma spectrometry using HP-germanium detectors. Most of the groups had excellent results. The groups became acquainted with each other. The personal contact makes it possible to get information quickly in case of accidents of nuclear power stations in the neighbourhood of Austria

  20. GPIB interface of IBM-PC compatible microcomputer and multimeter HP3457A for the automatization of temperature measurements

    International Nuclear Information System (INIS)

    Migliano, A.C.C.; Sircilli Neto, F.; Passaro, A.

    1990-01-01

    The measurement of temperature distribution of the beam transport devices, utilized in the IEAv linac, takes several hours to be completed. At the beam transport laboratory, these experiments are controlled with the help of a MS-quick BASIC code denominated TERMOJ. This code uses the software of STD-8410 plate to promote the communication between an IBM-PC compatible microcomputer and the programmable multimeter HP3457A via GPIB interface. This work presents information for the automation of experiments using thermocouples to obtain temperature distributions with the TERMOJ code. Also, suggestions of how modify the algorithm of the program for the specific situations are indicated. (author)

  1. EASI on the HP-25, HP-65, and HP-67

    International Nuclear Information System (INIS)

    Sasser, D.W.

    1977-05-01

    EASI (Estimate of Adversary Sequence Interruption) is an effective, simple method which has been developed for use in evaluating physical security systems. The usefulness of the method is enhanced by the fact that it can be implemented on a programmable pocket calculator. A program for the Texas Instruments SR-52 programmable pocket calculator has been developed and reported upon elsewhere. The purpose of this report is to provide programs for the Hewlett-Packard programmable pocket calculators

  2. Stability Estimates for h-p Spectral Element Methods for Elliptic Problems

    NARCIS (Netherlands)

    Dutt, Pravir; Tomar, S.K.; Kumar, B.V. Rathish

    2002-01-01

    In a series of papers of which this is the first we study how to solve elliptic problems on polygonal domains using spectral methods on parallel computers. To overcome the singularities that arise in a neighborhood of the corners we use a geometrical mesh. With this mesh we seek a solution which

  3. Cross-Validation of the Spanish HP-Version of the Jefferson Scale of Empathy Confirmed with Some Cross-Cultural Differences.

    Science.gov (United States)

    Alcorta-Garza, Adelina; San-Martín, Montserrat; Delgado-Bolton, Roberto; Soler-González, Jorge; Roig, Helena; Vivanco, Luis

    2016-01-01

    Medical educators agree that empathy is essential for physicians' professionalism. The Health Professional Version of the Jefferson Scale of Empathy (JSE-HP) was developed in response to a need for a psychometrically sound instrument to measure empathy in the context of patient care. Although extensive support for its validity and reliability is available, the authors recognize the necessity to examine psychometrics of the JSE-HP in different socio-cultural contexts to assure the psychometric soundness of this instrument. The first aim of this study was to confirm its psychometric properties in the cross-cultural context of Spain and Latin American countries. The second aim was to measure the influence of social and cultural factors on the development of medical empathy in health practitioners. The original English version of the JSE-HP was translated into International Spanish using back-translation procedures. The Spanish version of the JSE-HP was administered to 896 physicians from Spain and 13 Latin American countries. Data were subjected to exploratory factor analysis using principal component analysis (PCA) with oblique rotation (promax) to allow for correlation among the resulting factors, followed by a second analysis, using confirmatory factor analysis (CFA). Two theoretical models, one based on the English JSE-HP and another on the first Spanish student version of the JSE (JSE-S), were tested. Demographic variables were compared using group comparisons. A total of 715 (80%) surveys were returned fully completed. Cronbach's alpha coefficient of the JSE for the entire sample was 0.84. The psychometric properties of the Spanish JSE-HP matched those of the original English JSE-HP. However, the Spanish JSE-S model proved more appropriate than the original English model for the sample in this study. Group comparisons among physicians classified by gender, medical specialties, cultural and cross-cultural backgrounds yielded statistically significant differences

  4. Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway.

    Science.gov (United States)

    Garfinkel, Benjamin P; Arad, Shiri; Le, Phuong T; Bustin, Michael; Rosen, Clifford J; Gabet, Yankel; Orly, Joseph

    2015-12-01

    Heterochromatin protein 1 binding protein 3 (HP1BP3) is a recently described histone H1-related protein with roles in chromatin structure and transcriptional regulation. To explore the potential physiological role of HP1BP3, we have previously described an Hp1bp3(-/-) mouse model with reduced postnatal viability and growth. We now find that these mice are proportionate dwarfs, with reduction in body weight, body length, and organ weight. In addition to their small size, microcomputed tomography analysis showed that Hp1bp3(-/-) mice present a dramatic impairment of their bone development and structure. By 3 weeks of age, mice of both sexes have severely impaired cortical and trabecular bone, and these defects persist into adulthood and beyond. Primary cultures of both osteoblasts and osteoclasts from Hp1bp3(-/-) bone marrow and splenocytes, respectively, showed normal differentiation and function, strongly suggesting that the impaired bone accrual is due to noncell autonomous systemic cues in vivo. One major endocrine pathway regulating both body growth and bone acquisition is the IGF regulatory system, composed of IGF-1, the IGF receptors, and the IGF-binding proteins (IGFBPs). At 3 weeks of age, Hp1bp3(-/-) mice exhibited a 60% reduction in circulating IGF-1 and a 4-fold increase in the levels of IGFBP-1 and IGFBP-2. These alterations were reflected in similar changes in the hepatic transcripts of the Igf1, Igfbp1, and Igfbp2 genes. Collectively, these results suggest that HP1BP3 plays a key role in normal growth and bone development by regulating transcription of endocrine IGF-1 components.

  5. Experimental investigation of a PCM-HP heat sink on its thermal performance and anti-thermal-shock capacity for high-power LEDs

    International Nuclear Information System (INIS)

    Wu, Yuxuan; Tang, Yong; Li, Zongtao; Ding, Xinrui; Yuan, Wei; Zhao, Xuezhi; Yu, Binhai

    2016-01-01

    Highlights: • A phase-change material (PCM) base heat pipe heat sink (PCM-HP heat sink) is designed. • The PCM-HP heat sink can significantly lower the LED heating rate and temperature. • The PCM-HP heat sink achieves a best anti-thermal-shock capacity in LED cyclic working modes. - Abstract: High-power LEDs demonstrate a number of benefits compared with conventional incandescent lamps and fluorescent lamps, including a longer lifetime, higher brightness and lower power consumption. However, owing to their severe high heat flux, it is difficult to develop effective thermal management of high-power LEDs, especially under cyclic working modes, which cause serious periodic thermal stress and limit further development. Focusing on the above problem, this paper designed a phase-change material (PCM) base heat pipe heat sink (PCM-HP heat sink) that consists of a PCM base, adapter plate, heat pipe and finned radiator. Different parameters, such as three types of interior materials to fill the heat sink, three LED power inputs and eight LED cyclic working modes, were separately studied to investigate the thermal performance and anti-thermal-shock capacity of the PCM-HP heat sink. The results show that the PCM-HP heat sink possesses remarkable thermal performance owing to the reduction of the LED heating rate and peak temperature. More importantly, an excellent anti-thermal-shock capacity of the PCM-HP heat sink is also demonstrated when applied in LED cyclic working modes, and this capacity demonstrates the best range.

  6. Comparison of multimesh hp-FEM to interpolation and projection methods for spatial coupling of thermal and neutron diffusion calculations

    International Nuclear Information System (INIS)

    Dubcova, Lenka; Solin, Pavel; Hansen, Glen; Park, HyeongKae

    2011-01-01

    Multiphysics solution challenges are legion within the field of nuclear reactor design and analysis. One major issue concerns the coupling between heat and neutron flow (neutronics) within the reactor assembly. These phenomena are usually very tightly interdependent, as large amounts of heat are quickly produced with an increase in fission events within the fuel, which raises the temperature that affects the neutron cross section of the fuel. Furthermore, there typically is a large diversity of time and spatial scales between mathematical models of heat and neutronics. Indeed, the different spatial resolution requirements often lead to the use of very different meshes for the two phenomena. As the equations are coupled, one must take care in exchanging solution data between them, or significant error can be introduced into the coupled problem. We propose a novel approach to the discretization of the coupled problem on different meshes based on an adaptive multimesh higher-order finite element method (hp-FEM), and compare it to popular interpolation and projection methods. We show that the multimesh hp-FEM method is significantly more accurate than the interpolation and projection approaches considered in this study.

  7. Developmental validation of the Quantifiler(®) HP and Trio Kits for human DNA quantification in forensic samples.

    Science.gov (United States)

    Holt, Allison; Wootton, Sharon Chao; Mulero, Julio J; Brzoska, Pius M; Langit, Emanuel; Green, Robert L

    2016-03-01

    The quantification of human genomic DNA is a necessary first step in the DNA casework sample analysis workflow. DNA quantification determines optimal sample input amounts for subsequent STR (short tandem repeat) genotyping procedures, as well as being a useful screening tool to identify samples most likely to provide probative genotypic evidence. To better mesh with the capabilities of newest-generation STR analysis assays, the Quantifiler(®) HP and Quantifiler(®) Trio DNA Quantification Kits were designed for greater detection sensitivity and more robust performance with samples that contain PCR inhibitors or degraded DNA. The new DNA quantification kits use multiplex TaqMan(®) assay-based fluorescent probe technology to simultaneously quantify up to three human genomic targets, allowing samples to be assessed for total human DNA, male contributor (i.e., Y-chromosome) DNA, as well as a determination of DNA degradation state. The Quantifiler HP and Trio Kits use multiple-copy loci to allow for significantly improved sensitivity compared to earlier-generation kits that employ single-copy target loci. The kits' improved performance provides better predictive ability for results with downstream, newest-generation STR assays, and their shortened time-to-result allows more efficient integration into the forensic casework analysis workflow. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  8. Lactobacillus fermentum HP3-Mediated Fermented Hericium erinaceus Juice as a Health Promoting Food Supplement to Manage Diabetes Mellitus.

    Science.gov (United States)

    Chaiyasut, Chaiyavat; Woraharn, Sasimar; Sivamaruthi, Bhagavathi Sundaram; Lailerd, Narissara; Kesika, Periyanaina; Peerajan, Sartjin

    2018-01-01

    The current study investigated the antidiabetic property of Lactobacillus fermentum HP3-mediated fermented Hericium erinaceus juice (FHJ) using male Wistar rats with streptozotocin-induced diabetes mellitus (DM). FHJ was prepared using boiled mushroom juice and L. fermentum HP3. Amino acid and γ-aminobutyric acid (GABA) content of FHJ was analyzed. Streptozotocin-induced DM rats were supplemented with FHJ in a pre- and posttreatment method. The changes in plasma insulin, plasma glucose level, glycated hemoglobin (HbA1c), representative cytokines, and the antioxidant system were assessed in experimental rats using spectrophotometric methods and enzyme-linked immunosorbent assay. The supplementation of FHJ improved the body mass, insulin level, and recovery progress of hyperglycemia. HbA1c level was altered by the FHJ intervention. The inflammatory cytokines level was suppressed in FHJ supplemented group compared with control. Intervention of FHJ and insulin improved the production of interleukin-10 and transforming growth factor--β1 in DM rat. The study suggested that fermented H erinaceus juice may be used as one of the food-based health-promoting supplement to manage DM along with medication.

  9. Evaluation of personal dose equivalent 'HP(d)' in a external individual monitoring system for X and gamma radiation

    International Nuclear Information System (INIS)

    Santoro, C.; Antonio Filho, J.; Santos, M.A.P.

    2007-01-01

    The good of individual monitoring for external radiation is the assessment of occupational exposure from X and γ radiations in order to assure that the radiological conditions of the workplace are acceptable, safe and satisfactory. The evaluation of radiations doses for workers must not exceed dose limits specified for workers, according to national regulatory agencies. Nowadays, there are two external monitoring systems in use, both based on ICRU definitions. In the conventional system, the workers doses are evaluated in terms of Hx. The personal dosimeter is worn over chest surface and it is calibrated in function of air kerma. In the new system, the workers doses are evaluated in terms of HP(d) and the personal dosimeter is calibrated in function of phantom doses. The aim of this paper is to adapt an external dosimetry laboratory (based on photographic dosimetry) to evaluate the personal dosimeters in terms of HP(d). In this way, a simple methodology, based on linear programming, was utilized. In this adaptation, calibration curves were obtained for radiation qualities (W and N series) described by International Organization for Standardization (ISO 4037-1, 1995). These calibration curves offer a better accuracy on dose determinations and energy below 140 keV, improving the quality of service rendered the society. (author)

  10. A proposal for a test method for assessment of hazard property HP 12 ("Release of an acute toxic gas") in hazardous waste classification - Experience from 49 waste.

    Science.gov (United States)

    Hennebert, Pierre; Samaali, Ismahen; Molina, Pauline

    2016-12-01

    A stepwise method for assessment of the HP 12 is proposed and tested with 49 waste samples. The hazard property HP 12 is defined as "Release of an acute toxic gas": waste which releases acute toxic gases (Acute Tox. 1, 2 or 3) in contact with water or an acid. When a waste contains a substance assigned to one of the following supplemental hazards EUH029, EUH031 and EUH032, it shall be classified as hazardous by HP 12 according to test methods or guidelines (EC, 2014a, 2014b). When the substances with the cited hazard statement codes react with water or an acid, they can release HCl, Cl 2 , HF, HCN, PH 3 , H 2 S, SO 2 (and two other gases very unlikely to be emitted, hydrazoic acid HN 3 and selenium oxide SeO 2 - a solid with low vapor pressure). Hence, a method is proposed:For a set of 49 waste, water addition did not produce gas. Nearly all the solid waste produced a gas in contact with hydrochloric acid in 5 min in an automated calcimeter with a volume >0.1L of gas per kg of waste. Since a plateau of pressure is reached only for half of the samples in 5 min, 6 h trial with calorimetric bombs or glass flasks were done and confirmed the results. Identification of the gases by portable probes showed that most of the tested samples emit mainly CO 2 . Toxic gases are emitted by four waste: metallic dust from the aluminum industry (CO), two air pollution control residue of industrial waste incinerator (H 2 S) and a halogenated solvent (organic volatile(s) compound(s)). HF has not been measured in these trials started before the present definition of HP 12. According to the definition of HP 12, only the H 2 S emission of substances with hazard statement EUH031 is accounted for. In view of the calcium content of the two air pollution control residue, the presence of calcium sulphide (EUH031) can be assumed. These two waste are therefore classified potentially hazardous for HP 12, from a total of 49 waste. They are also classified as hazardous for other properties (HP 7

  11. The intercomparison of 137Cs irradiator output measurement and personal dose equivalent, Hp(10), using TLD and film

    International Nuclear Information System (INIS)

    Nazaroh; Susetyo Trijoko; Sri Inang Sunaryati

    2010-01-01

    Intercomparison of output measurement of 137 Cs irradiator and personal dose equivalent, Hp(10) using TLD and film have been carried out in the year of 2006 to 2008. According to IAEA recommendation, intercomparison is one of audit activities but it is performed in the spirit of collaboration and support rather than in the spirit of inspection. The aim of intercomparison of output measurement of 137 Cs irradiator is to verify the dose stated by the participant laboratories. Intercomparison is also to assess the competency of the participant, to keep traceability and consistency of measurement result, to assure that instrument work correctly and the result of evaluation was in agreement, and also for fulfilling one of the clauses of ISO-17025-2005. Besides that, this intercomparison aimed to facilitate link between the system and members of national measurement and transfer of experience in measurement technique and dose evaluation of radiation. The benefit of intercomparison is important among others as tests of proficiency in dose evaluation or measurement, upgrading quality of service and for obeying supervisor body legislation (BAPETEN). TLD was used as a means of output 137 Cs irradiator measurement, whereas film and TLD were used for dose intercomparison. This paper presented result of intercomparison of output measurement and evaluation of personal dose equivalent, Hp(10) in the year of 2006 to 2008 followed by 6 participants: Balai Pengamanan Fasilitas Kesehatan (BPFK) Jakarta, Medan, Surabaya, Makasar, PTLR and Laboratory of Keselamatan dan Kesehatan Lingkungan (KKL)-PTKMR BATAN. In this intercomparison, the dose of TLD stated by participant were compared with the dose measured by Radiation Metrology Laboratory (LMR), and the results showed the differences were within 10 %, so it was satisfied. The results of intercomparison of personal dose equivalent, Hp(10) were evaluated based on ISO/IEC Guide 43-1, 1997 analysis and expressed as E n . The values of E n

  12. Stability of Basalt plus Anhydrite plus Calcite at HP-HT: Implications for Venus, the Earth and Mars

    Science.gov (United States)

    Martin, A. M.; Righter, K.; Treiman, A. H.

    2010-01-01

    "Canali" observed at Venus surface by Magellan are evidence for very long melt flows, but their composition and origin remain uncertain. The hypothesis of water-rich flow is not reasonable regarding the temperature at Venus surface. The length of these channels could not be explained by a silicate melt composition but more likely, by a carbonate-sulfate melt which has a much lower viscosity (Kargel et al 1994). One hypothesis is that calcite CaCO3 and anhydrite CaSO4 which are alteration products of basalts melted during meteorite impacts. A famous example recorded on the Earth (Chicxulub) produced melt and gas rich in carbon and sulfur. Calcite and sulfate evaporites are also present on Mars surface, associated with basalts. An impact on these materials might release C- and S-rich melt or fluid. Another type of planetary phenomenon (affecting only the Earth) might provoke a high pressure destabilization of basalt+anhydrite+calcite. Very high contents of C and S are measured in some Earth s magmas, either dissolved or in the form of crystals (Luhr 2008). As shown by the high H content and high fO2 of primary igneous anhydrite-bearing lavas, the high S content in their source may be explained by subduction of an anhydrite-bearing oceanic crust, either directly (by melting followed by eruption) or indirectly (by release of S-rich melt or fluid that metasomatize the mantle) . Calcite is a major product of oceanic sedimentation and alteration of the crust. Therefore, sulfate- and calcite-rich material may be subducted to high pressures and high temperatures (HP-HT) and release S- and C-rich melts or fluids which could influence the composition of subduction zone lavas or gases. Both phenomena - meteorite impact and subduction - imply HP-HT conditions - although the P-T-time paths are different. Some HP experimental/theoretical studies have been performed on basalt/eclogite, calcite and anhydrite separately or on a combination of two. In this study we performed piston

  13. Liposome-encapsulated EF24-HP{beta}CD inclusion complex: a preformulation study and biodistribution in a rat model

    Energy Technology Data Exchange (ETDEWEB)

    Agashe, H; Lagisetty, P; Sahoo, K; Bourne, D [University of Oklahoma Health Sciences Center, Department of Pharmaceutical Sciences (United States); Grady, B [School of Chemical, Biological and Materials Engineering (United States); Awasthi, V [University of Oklahoma Health Sciences Center, Department of Pharmaceutical Sciences (United States)

    2011-06-15

    3,5-Bis(2-fluorobenzylidene)-4-piperidone (EF24) is an anti-proliferative diphenyldifluoroketone analog of curcumin with more potent activity. The authors describe a liposome preparation of EF24 using a 'drug-in-CD-in liposome' approach. An aqueous solution of EF24 and hydroxypropyl-{beta}-cyclodextrin (HP{beta}CD) inclusion complex (IC) was used to prepare EF24 liposomes. The liposome size was reduced by a combination of multiple freeze-thaw cycles. Co-encapsulation of glutathione inside the liposomes conferred them with the capability of labeling with imageable radionuclide Tc-99m. Phase solubility analysis of EF24-HP{beta}CD mixture provided k{sub 1:1} value of 9.9 M{sup -1}. The enhanced aqueous solubility of EF24 (from 1.64 to 13.8 mg/mL) due to the presence of HP{beta}CD helped in the liposome preparation. About 19% of the EF24 IC was encapsulated inside the liposomes (320.5 {+-} 2.6 nm) by dehydration-rehydration technique. With extrusion technique, the size of 177 {+-} 6.5 nm was obtained without any effect on encapsulation efficiency. The EF24-liposomes were evaluated for anti-proliferative activity in lung adenocarcinoma H441 and prostate cancer PC-3 cells. The EF24-liposomes demonstrated anti-proliferative activity superior to that of plain EF24 at 10 {mu}M dose. When injected in rats, the Tc-99m-labeled EF24-liposomes cleared from blood with an {alpha}-t{sub 1/2} of 21.4 min and {beta}-t{sub 1/2} of 397 min. Tissue radioactivity counting upon necropsy showed that the majority of clearance was due to the uptake in liver and spleen. The results suggest that using 'drug-in-CD-in liposome' approach is a feasible strategy to formulate an effective parenteral preparation of EF24. In vitro studies show that the liposomal EF24 remains anti-proliferative, while presenting an opportunity to image its biodistribution.

  14. Liposome-encapsulated EF24-HP{beta}CD inclusion complex: a preformulation study and biodistribution in a rat model

    Energy Technology Data Exchange (ETDEWEB)

    Agashe, H.; Lagisetty, P.; Sahoo, K.; Bourne, D. [University of Oklahoma Health Sciences Center, Department of Pharmaceutical Sciences (United States); Grady, B. [School of Chemical, Biological and Materials Engineering (United States); Awasthi, V., E-mail: vawasthi@ouhsc.edu [University of Oklahoma Health Sciences Center, Department of Pharmaceutical Sciences (United States)

    2011-06-15

    3,5-Bis(2-fluorobenzylidene)-4-piperidone (EF24) is an anti-proliferative diphenyldifluoroketone analog of curcumin with more potent activity. The authors describe a liposome preparation of EF24 using a 'drug-in-CD-in liposome' approach. An aqueous solution of EF24 and hydroxypropyl-{beta}-cyclodextrin (HP{beta}CD) inclusion complex (IC) was used to prepare EF24 liposomes. The liposome size was reduced by a combination of multiple freeze-thaw cycles. Co-encapsulation of glutathione inside the liposomes conferred them with the capability of labeling with imageable radionuclide Tc-99m. Phase solubility analysis of EF24-HP{beta}CD mixture provided k{sub 1:1} value of 9.9 M{sup -1}. The enhanced aqueous solubility of EF24 (from 1.64 to 13.8 mg/mL) due to the presence of HP{beta}CD helped in the liposome preparation. About 19% of the EF24 IC was encapsulated inside the liposomes (320.5 {+-} 2.6 nm) by dehydration-rehydration technique. With extrusion technique, the size of 177 {+-} 6.5 nm was obtained without any effect on encapsulation efficiency. The EF24-liposomes were evaluated for anti-proliferative activity in lung adenocarcinoma H441 and prostate cancer PC-3 cells. The EF24-liposomes demonstrated anti-proliferative activity superior to that of plain EF24 at 10 {mu}M dose. When injected in rats, the Tc-99m-labeled EF24-liposomes cleared from blood with an {alpha}-t{sub 1/2} of 21.4 min and {beta}-t{sub 1/2} of 397 min. Tissue radioactivity counting upon necropsy showed that the majority of clearance was due to the uptake in liver and spleen. The results suggest that using 'drug-in-CD-in liposome' approach is a feasible strategy to formulate an effective parenteral preparation of EF24. In vitro studies show that the liposomal EF24 remains anti-proliferative, while presenting an opportunity to image its biodistribution.

  15. Performance Evaluation of HP/ORC (Heat Pump/Organic Rankine Cycle) System with Optimal Control of Sensible Thermal Storage

    DEFF Research Database (Denmark)

    Do Carmo, Carolina Madeira Ramos; Dumont, Olivier; Nielsen, Mads Pagh

    2016-01-01

    In energy systems with high share of renewable energy sources, like wind and solar power, it is paramount to deal with their intrinsic variability. The interaction between electric and thermal energy (heating and cooling) demands represent a potential area for balancing supply and demand that could...... come to contribute to the integration of intermittent renewables.This paper describes an innovative concept that consists of the addition of an Organic Rankine Cycle (ORC) to a combined solar system coupled to a ground-source heat pump (HP) in a single-family building. The ORC enables the use of solar...... energy in periods of no thermal energy demand and reverses the heat pump cycle to supply electrical power. A dynamic model based on empirical data of this system is used to determine the annual performance. Furthermore, this work assesses the benefits of different control strategies that address...

  16. Finite Element Modeling of Material Fatigue and Cracking Problems for Steam Power System HP Devices Exposed to Thermal Shocks

    Directory of Open Access Journals (Sweden)

    Pawlicki Jakub

    2016-09-01

    Full Text Available The paper presents a detailed analysis of the material damaging process due to low-cycle fatigue and subsequent crack growth under thermal shocks and high pressure. Finite Element Method (FEM model of a high pressure (HP by-pass valve body and a steam turbine rotor shaft (used in a coal power plant is presented. The main damaging factor in both cases is fatigue due to cycles of rapid temperature changes. The crack initiation, occurring at a relatively low number of load cycles, depends on alternating or alternating-incremental changes in plastic strains. The crack propagation is determined by the classic fracture mechanics, based on finite element models and the most dangerous case of brittle fracture. This example shows the adaptation of the structure to work in the ultimate conditions of high pressure, thermal shocks and cracking.

  17. Modelling, experimentation and simulation of a reversible HP/ORC unit to get a Positive Energy Building

    DEFF Research Database (Denmark)

    Dumont, Olivier; Carmo, Carolina; Quoilin, Sylvain

    2015-01-01

    This paper presents an innovative building comprising a heat pump connected to a solar roof and a geothermal heat exchanger. This unit is able to invert its cycle and operate as an Organic Rankine Cycle (ORC). The solar roof is producing large amount of heat throughout the year. This allows...... and fluid R134a shows promising performance with a net electrical energy produced over one year reaching 4030 kWh. Following that, a prototype has been built and has proven the feasibility of the technology. Finally, a simulation code including the building, the ground heat exchanger, the thermal energy...... storage, the solar roof and the reversible HP/ORC unit is developed and allows to perform a sensivity analysis. Annual results show that this technology leads to a Positive Energy Building....

  18. Finite element analysis of the Girkmann problem using the modern hp-version and the classical h-version

    KAUST Repository

    Niemi, Antti

    2011-06-03

    We perform finite element analysis of the so called Girkmann problem in structural mechanics. The problem involves an axially symmetric spherical shell stiffened with a foot ring and is approached (1) by using the axisymmetric formulation of linear elasticity theory and (2) by using a dimensionally reduced shell-ring model. In the first approach the problem is solved with a fully automatic hp-adaptive finite element solver whereas the classical h-version of the finite element method is used in the second approach. We study the convergence behaviour of the different numerical models and show that accurate stress resultants can be obtained with both models by using effective post-processing formulas. © Springer-Verlag London Limited 2011.

  19. Shape Optimization of Impeller Blades for 15,000 HP Centrifugal Compressor Using Fluid Structural Interaction Analysis

    International Nuclear Information System (INIS)

    Kang, Hyun Su; Oh, Jeongsu; Han, Jeong Sam

    2014-01-01

    This paper discusses a one-way fluid structural interaction (FSI) analysis and shape optimization of the impeller blades for a 15,000 HP centrifugal compressor using the response surface method (RSM). Because both the aerodynamic performance and the structural safety of the impeller are affected by the shape of its blades, shape optimization is necessary using the FSI analysis, which includes a structural analysis for the induced fluid pressure and centrifugal force. The FSI analysis is performed in ANSYS Workbench: ANSYS CFX is used for the flow field and ANSYS Mechanical is used for the structural field. The response surfaces for the FSI results (efficiency, pressure ratio, maximum stress, etc.) generated based on the design of experiments (DOE) are used to find an optimal shape for the impeller blades, which provides the maximum aerodynamic performance subject to the structural safety constraints

  20. Shape Optimization of Impeller Blades for 15,000 HP Centrifugal Compressor Using Fluid Structural Interaction Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hyun Su [Sungkyunkwan University, Suwon (Korea, Republic of); Oh, Jeongsu [Daejoo Machinery Co., Daegu (Korea, Republic of); Han, Jeong Sam [Andong National University, Andong (Korea, Republic of)

    2014-06-15

    This paper discusses a one-way fluid structural interaction (FSI) analysis and shape optimization of the impeller blades for a 15,000 HP centrifugal compressor using the response surface method (RSM). Because both the aerodynamic performance and the structural safety of the impeller are affected by the shape of its blades, shape optimization is necessary using the FSI analysis, which includes a structural analysis for the induced fluid pressure and centrifugal force. The FSI analysis is performed in ANSYS Workbench: ANSYS CFX is used for the flow field and ANSYS Mechanical is used for the structural field. The response surfaces for the FSI results (efficiency, pressure ratio, maximum stress, etc.) generated based on the design of experiments (DOE) are used to find an optimal shape for the impeller blades, which provides the maximum aerodynamic performance subject to the structural safety constraints.

  1. High-Pressure Spark Plasma Sintering (HP SPS): A Promising and Reliable Method for Preparing Ti-Al-Si Alloys.

    Science.gov (United States)

    Knaislová, Anna; Novák, Pavel; Cygan, Sławomir; Jaworska, Lucyna; Cabibbo, Marcello

    2017-04-27

    Ti-Al-Si alloys are prospective material for high-temperature applications. Due to low density, good mechanical properties, and oxidation resistance, these intermetallic alloys can be used in the aerospace and automobile industries. Ti-Al-Si alloys were prepared by powder metallurgy using reactive sintering, milling, and spark plasma sintering. One of the novel SPS techniques is high-pressure spark plasma sintering (HP SPS), which was tested in this work and applied to a Ti-10Al-20Si intermetallic alloy using a pressure of 6 GPa and temperatures ranging from 1318 K (1045 °C) to 1597 K (1324 °C). The low-porosity consolidated samples consist of Ti₅Si₃ silicides in an aluminide (TiAl) matrix. The hardness varied between 720 and 892 HV 5.

  2. Test of ring, eye lens and whole body dosemeters for the dose quantity Hp(3) to be used in interventional radiology

    Science.gov (United States)

    Szumska, A.; Budzanowski, M.; Kopeć, R.

    2017-11-01

    In its statement on tissue reactions approved on 21st April 2011, the International Commission on Radiological Protection (ICRP, 2012) reviewed its recommendation concerning the equivalent dose limit for the eye lens and reduced the dose limits for occupationally exposed persons to 20 mSv in a year, averaged over defined periods of 5 years, with no single year exceeding 50 mSv. This limit was approved and written down in the new EURATOM (European Atomic Energy Community) directive 2013/59 and in the IAEA (International Atomic Energy Agency) BSS (Basic Safety Standard) of July 2014. For that reason, the necessity to monitor the eye lens may become more important than it was before. However, specially dedicated dosemeters for the dose quantity Hp(3) are using very rarely. Commonly use are only whole body personal dosemeters for the personal dose equivalent quantities Hp(10) worn on the trunk and ring dosemeters worn on finger to measure the quantity Hp(0.07). Therefore, in this work it was investigated whether dosemeters from routine use calibrated in terms of Hp(10) and Hp(0.07) and worn on thyroid collar and protective apron could deliver similar results like dedicated eye lens dosemeter worn close to the eyes. The results show that the best method if dedicated eye lens dosimeters is not used is to measure doses in terms of Hp(0.07) on the thyroid collar (Pearson product, r=0.85). Obtained results shows also importance of proper localization of eye lens dosimeter (close to the eye, from side of the X-ray source).

  3. VLBA DETERMINATION OF THE DISTANCE TO NEARBY STAR-FORMING REGIONS. III. HP TAU/G2 AND THE THREE-DIMENSIONAL STRUCTURE OF TAURUS

    International Nuclear Information System (INIS)

    Torres, Rosa M.; Loinard, Laurent; Rodriguez, Luis F.; Mioduszewski, Amy J.

    2009-01-01

    Using multiepoch Very Long Baseline Array (VLBA) observations, we have measured the trigonometric parallax of the weak-line T Tauri star HP Tau/G2 in Taurus. The best fit yields a distance of 161.2 ± 0.9 pc, suggesting that the eastern portion of Taurus (where HP Tau/G2 is located) corresponds to the far side of the complex. Previous VLBA observations have shown that T Tau, to the south of the complex, is at an intermediate distance of about 147 pc, whereas the region around L1495 corresponds to the near side at roughly 130 pc. Our observations of only four sources are still too coarse to enable a reliable determination of the three-dimensional structure of the entire Taurus star-forming complex. They do demonstrate, however, that VLBA observations of multiple sources in a given star-forming region have the potential not only to provide a very accurate estimate of its mean distance, but also to reveal its internal structure. The proper motion measurements obtained simultaneously with the parallax allowed us to study the kinematics of the young stars in Taurus. Combining the four observations available so far, we estimate the peculiar velocity of Taurus to be about 10.6 km s -1 almost completely in a direction parallel to the Galactic plane. Using our improved distance measurement, we have refined the determination of the position on the H-R diagram of HP Tau/G2, and of two other members of the HP Tau group (HP Tau itself and HP Tau/G3). Most pre-main-sequence evolutionary models predict significantly discrepant ages (by 5 Myr) for those three stars-expected to be coeval. Only in the models of Palla and Stahler do they fall on a single isochrone (at 3 Myr).

  4. Segmented quasi-coaxial HP-Ge detectors optimized for spatial localization of the events

    International Nuclear Information System (INIS)

    Ripamonti, Giancarlo; Pulici, Paolo; Abbiati, Roberto

    2006-01-01

    A methodology for the design of segmented high purity Germanium detectors is presented. Its motivation follows from the necessity of making it easier to derive fast algorithms for measuring the gamma-detector interaction position. By using our study, detector geometries can be designed, which could allow a first estimate of the interaction coordinate along the carrier drift direction by analyzing the shape of the signal of a single segment. The maximum resolution that can be achieved and the corresponding conditions for the electronics are highlighted: basic unavoidable constraints limit the resolution to around 3 mm, but this first position estimate can be used, at least in principle, as a starting point for more accurate, although computationally heavy, algorithms

  5. HP1330 Contributes to Streptococcus suis Virulence by Inducing Toll-Like Receptor 2- and ERK1/2-Dependent Pro-inflammatory Responses and Influencing In Vivo S. suis Loads

    Directory of Open Access Journals (Sweden)

    Qiang Zhang

    2017-07-01

    Full Text Available Streptococcus suis 2 (SS2 has evolved into a highly invasive pathogen responsible for two large-scale outbreaks of streptococcal toxic shock-like syndrome (STSLS in China. Excessive inflammation stimulated by SS2 is considered a hallmark of STSLS, even it also plays important roles in other clinical symptoms of SS2-related disease, including meningitis, septicemia, and sudden death. However, the mechanism of SS2-caused excessive inflammation remains poorly understood. Here, a novel pro-inflammatory protein was identified (HP1330, which could induce robust expression of pro-inflammatory cytokines (TNF-α, MCP-1, and IL-1β in RAW264.7 macrophages. To evaluate the role of HP1330 in SS2 virulence, an hp1330-deletion mutant (Δhp1330 was constructed. In vitro, hp1330 disruption led to a decreased pro-inflammatory ability of SS2 in RAW 264.7 macrophages. In vivo, Δhp1330 showed reduced lethality, pro-inflammatory activity, and bacterial loads in mice. To further elucidate the mechanism of HP1330-induced pro-inflammatory cytokine production, antibody blocking and gene-deletion experiments with macrophages were performed. The results revealed that the pro-inflammatory activity of HP1330 depended on the recognition of toll-like receptor 2 (TLR2. Furthermore, a specific inhibitor of the extracellular signal-regulated kinase 1/2 (ERK1/2 pathways could significantly decrease HP1330-induced pro-inflammatory cytokine production, and western blot analysis showed that HP1330 could induce activation of the ERK1/2 pathway. Taken together, our findings demonstrate that HP1330 contributes to SS2 virulence by inducing TLR2- and ERK1/2-dependent pro-inflammatory cytokine production and influencing in vivo bacterial loads, implying that HP1330 may be associated with STSLS caused by SS2.

  6. The numerical parallel computing of photon transport

    International Nuclear Information System (INIS)

    Huang Qingnan; Liang Xiaoguang; Zhang Lifa

    1998-12-01

    The parallel computing of photon transport is investigated, the parallel algorithm and the parallelization of programs on parallel computers both with shared memory and with distributed memory are discussed. By analyzing the inherent law of the mathematics and physics model of photon transport according to the structure feature of parallel computers, using the strategy of 'to divide and conquer', adjusting the algorithm structure of the program, dissolving the data relationship, finding parallel liable ingredients and creating large grain parallel subtasks, the sequential computing of photon transport into is efficiently transformed into parallel and vector computing. The program was run on various HP parallel computers such as the HY-1 (PVP), the Challenge (SMP) and the YH-3 (MPP) and very good parallel speedup has been gotten

  7. HP-Multigrid as Smoother algorithm for higher order discontinuous Galerkin discretizations of advection dominated flows. Part II: Optimization of the Runge-Kutta smoother

    NARCIS (Netherlands)

    van der Vegt, Jacobus J.W.; Rhebergen, Sander

    2012-01-01

    Using a detailed multilevel analysis of the complete hp-Multigrid as Smoother algorithm accurate predictions are obtained of the spectral radius and operator norms of the multigrid error transformation operator. This multilevel analysis is used to optimize the coefficients in the semi-implicit

  8. Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells

    International Nuclear Information System (INIS)

    Oka, Yasuyoshi; Suzuki, Keiji; Yamauchi, Motohiro; Mitsutake, Norisato; Yamashita, Shunichi

    2011-01-01

    Highlights: → NIPBL is recruited to DSBs. → Localization of NIPBL to DSBs is regulated by MDC1 and RNF168. → HP1γ is required for NIPBL accumulation at DSBs. -- Abstract: The cohesin loading factor NIPBL is required for cohesin to associate with chromosomes and plays a role in DNA double-strand break (DSB) repair. Although the NIPBL homolog Scc2 is recruited to an enzymatically generated DSB and promotes cohesin-dependent DSB repair in yeast, the mechanism of the recruitment remains poorly understood. Here we show that the human NIPBL is recruited to the sites of DNA damage generated by micro-irradiation as well as to the sites of DSBs induced by homing endonuclease, I-PpoI. The recruitment of NIPBL was impaired by RNAi-mediated knockdown of MDC1 or RNF168, both of which also accumulate at DSBs. We also show that the recruitment of NIPBL to the sites of DNA damage is mediated by its C-terminal region containing HEAT repeats and Heterochromatin protein 1 (HP1) interacting motif. Furthermore, NIPBL accumulation at damaged sites was also compromised by HP1γ depletion. Taken together, our study reveals that human NIPBL is a novel protein recruited to DSB sites, and the recruitment is controlled by MDC1, RNF168 and HP1γ.

  9. Cross-validation of the Spanish HP-Version of the Jefferson Scale of Empathy confirmed with some cross-cultural differences

    Directory of Open Access Journals (Sweden)

    Adelina Alcorta-Garza

    2016-07-01

    Full Text Available Context: Medical educators agree that empathy is essential for physicians’ professionalism. The Health Professional Version of the Jefferson Scale of Empathy (JSE-HP was developed in response to a need for a psychometrically sound instrument to measure empathy in the context of patient care. Although extensive support for its validity and reliability is available, the authors recognize the necessity to examine psychometrics of the JSE-HP in different socio-cultural contexts to assure the psychometric soundness of this instrument. The first aim of this study was to confirm its psychometric properties in the cross-cultural context of Spain and Latin American countries. The second aim was to measure the influence of social and cultural factors on the development of medical empathy in health practitioners.Methods: The original English version of the JSE-HP was translated into International Spanish using back-translation procedures. The Spanish version of the JSE-HP was administered to 896 physicians from Spain and thirteen Latin American countries. Data were subjected to exploratory factor analysis using principal component analysis with oblique rotation (promax to allow for correlation among the resulting factors, followed by a second analysis, using confirmatory factor analysis. Two theoretical models, one based on the English JSE-HP and another on the first Spanish student version of the JSE (JSE-S, were tested. Demographic variables were compared using group comparisons.Results: A total of 715 (80% surveys were returned fully completed. Cronbach’s alpha coefficient of the JSE for the entire sample was 0.84. The psychometric properties of the Spanish JSE-HP matched those of the original English JSE-HP. However, the Spanish JSE-S model proved more appropriate than the original English model for the sample in this study. Group comparisons among physicians classified by gender, medical specialties, cultural and cross-cultural backgrounds yielded

  10. Modeling of Yield Estimation for The Main Crops in Iran Based on Mechanization Index (hp ha-1

    Directory of Open Access Journals (Sweden)

    K Abbasi

    2014-09-01

    Full Text Available Agricultural mechanization is a method for transiting from traditional agriculture towards industrial and sustainable one. Due to the limitation of natural resources and increasing population we need to have economical production of agricultural crops. For reaching this destination; agricultural mechanization has a remarkable role. So it is necessary to have an extensive view for mechanization, because with the help of mechanization the agricultural inputs such as seeds, fertilizer and even water and soil can effectively be managed for an economical and sustainable production. This study has been carried out in many provinces of Iran. The data of agricultural tractors and cereal combine harvesters were firstly gathered by means of questionnaire. The tractors were categorized in four power levels of less than 45, 45 to 80, 80 to 110, and more than 110 hp. In addition, it was also carried out for cereal combine harvesters; it was in three power levels, i.e. between 100 to 110, 110 to 155 and 155 to 210 horse-power in 3 ages, i.e. less than 13, between 13 to 20, and more than 20 years. Information regarding to cultivation areas, production volume, and yield of main crops gathered from statistics of Ministry of Jihad-e-Agriculture. Then agriculture mechanization level index (hp ha-1 in each province was calculated. Four main crops including irrigated and rain-fed wheat and irrigated and rain-fed barley, which met the required criteria to be used in the model, were statistically analyzed. Correlation analysis was carried out in order to get an effective model between yield of the four main crops in Iran and agriculture mechanization level index. Pearson correlation index showed that there is a direct and significant correlation between these variables. Subsequently, outliers were identified in order to get a model with necessary efficiency to predict the yield through mechanization level index, by scatter diagram and estimating regression lines in 1

  11. Comparative study in LTC Combustion between a short HP EGR loop without cooler and a variable lift and duration system

    Energy Technology Data Exchange (ETDEWEB)

    Bression, Guillaume; Pacaud, Pierre; Soleri, Dominique; Cessou, Jerome [IFP (France); Azoulay, David [Renault Powertrain Div. (France); Lawrence, David [Mechadyne (United Kingdom); Doradoux, Laurent; Guerrassi, Noureddine [Delphi Diesel Systems (France)

    2008-07-01

    In order to reach future Diesel emission standards such as Euro 6 or Tier 2 Bin 5, NO{sub x} emissions need to be dramatically reduced. Advanced technologies and engine settings such as higher EGR rates, reduced compression ratio, EGR cooler and low-pressure EGR loop - depending on vehicle application - may help to reach this target whilst maintaining low CO{sub 2} emissions and fuel consumption. However, the resulting low combustion temperatures and the low air-fuel ratios lead to a significant increase in HC and CO emissions, especially during the start-up phase prior to catalyst light-off. Moreover, high levels of EGR make transient operation even more difficult. So HC-CO emissions and EGR transient operation represent two key issues that could limit the extension of this alternative combustion mode. Consequently, an in-depth investigation of a variable lift and duration (VLD) system was performed to overcome these problems on a 4-cylinder engine, which was also equipped with a dual HP-LP EGR loop. The VLD system tested in this paper produces a variable camshaft-operated exhaust valve re-opening, which is controlled by a hydraulic rotary actuator, ensuring quick and accurate regulation of the internal gas recirculation (IGR). By increasing gas temperature in the combustion chamber, this advanced technology allows us to reduce HC-CO emissions by 50% under 3 bar BMEP. Although efficient, this technology has to be compared with other solutions from a cost-to-value point of view. The aim of this paper is firstly to compare the double lift exhaust system with a short route high-performance EGR loop without cooler by quantifying their respective gains on steady state points of the NEDC cycle, then by evaluating their potential performances during transient conditions. With the short-route EGR, the potential in HC-CO emission reduction remains significant on a large scale of engine temperatures representative of engine warm up. However, the VLD system allows us to

  12. Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.

    Directory of Open Access Journals (Sweden)

    Nicole C Riddle

    2012-09-01

    Full Text Available Chromatin environments differ greatly within a eukaryotic genome, depending on expression state, chromosomal location, and nuclear position. In genomic regions characterized by high repeat content and high gene density, chromatin structure must silence transposable elements but permit expression of embedded genes. We have investigated one such region, chromosome 4 of Drosophila melanogaster. Using chromatin-immunoprecipitation followed by microarray (ChIP-chip analysis, we examined enrichment patterns of 20 histone modifications and 25 chromosomal proteins in S2 and BG3 cells, as well as the changes in several marks resulting from mutations in key proteins. Active genes on chromosome 4 are distinct from those in euchromatin or pericentric heterochromatin: while there is a depletion of silencing marks at the transcription start sites (TSSs, HP1a and H3K9me3, but not H3K9me2, are enriched strongly over gene bodies. Intriguingly, genes on chromosome 4 are less frequently associated with paused polymerase. However, when the chromatin is altered by depleting HP1a or POF, the RNA pol II enrichment patterns of many chromosome 4 genes shift, showing a significant decrease over gene bodies but not at TSSs, accompanied by lower expression of those genes. Chromosome 4 genes have a low incidence of TRL/GAGA factor binding sites and a low T(m downstream of the TSS, characteristics that could contribute to a low incidence of RNA polymerase pausing. Our data also indicate that EGG and POF jointly regulate H3K9 methylation and promote HP1a binding over gene bodies, while HP1a targeting and H3K9 methylation are maintained at the repeats by an independent mechanism. The HP1a-enriched, POF-associated chromatin structure over the gene bodies may represent one type of adaptation for genes embedded in repetitive DNA.

  13. Peak {sup 14}CO{sub 2} excretion, symptoms and eradication of H.Pylori (HP) in patients with duodenal ulcer (DU)

    Energy Technology Data Exchange (ETDEWEB)

    Batholomeusz, F.D.L.; Bellon, M. [Royal Adelaide Hospital, Adelaide, SA (Australia). Department of Nuclear Medicine

    1997-12-01

    Full text: Many factors including drug efficacy, compliance and antibiotic resistance may influence HP eradication rates. The {sup 14}C urea breath test is a sensitive method of confirming HP colonisation and eradication. The aim was to study the relationships between the peak {sup 14}CO{sub 2} counts on the breath test prior to treatment, smoking and HP eradication, and to assess if persistent or recurrent symptoms implied failure of eradication. 117 patients with DU and HP colonisation proved on biopsy or rapid urease test who underwent {sup 14}C urea breath tests at least one month after eradication treatment was ceased were studied (69 male, 48 female, mean age 41, range 26-87 y). Questionnaire assessment of treatment regimen, smoking history and dyspeptic symptoms was made at the time of the breath test. A sub-group of 43 patients who had pre- and post-treatment breath tests was studied to assess if high peak {sup 14}CO{sub 2} counts on the pre-treatment breath test related to treatment success. The mean peak initial {sup 14}CO{sub 2} excretion in those who were treated successfully was 4187 (+ 472) counts/min and for failures 4817 (+739) counts/min (p 0.24). Dyspeptic symptoms were present in 36% of patients treated successfully and 37% where treatment failed. The eradication rate for the 56 smokers was 75 per cent, and the 61 non-smokers 83%. (p>0.2) High {sup 14}CO{sub 2} excretion on the initial {sup 14}C urea breath test and smoking are not associated with a significantly lower rate of HP eradication and the presence of dyspepsia is not a good indicator of persistent infection

  14. Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance.

    Directory of Open Access Journals (Sweden)

    Rebecca E Symula

    Full Text Available Trypanosoma brucei rhodesiense (Tbr and T. b. gambiense (Tbg, causative agents of Human African Trypanosomiasis (sleeping sickness in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs, components of innate immunity in human serum that protect against infection by other African trypanosomes. In Tbr, lytic activity is suppressed by the Tbr-specific serum-resistance associated (SRA protein. The mechanism in Tbg is less well understood but has been hypothesized to involve altered activity and expression of haptoglobin haemoglobin receptor (HpHbR. HpHbR has been shown to facilitate internalization of TLF-1 in T.b. brucei (Tbb, a member of the T. brucei species complex that is susceptible to human serum. By evaluating the genetic variability of HpHbR in a comprehensive geographical and taxonomic context, we show that a single substitution that replaces leucine with serine at position 210 is conserved in the most widespread form of Tbg (Tbg group 1 and not found in related taxa, which are either human serum susceptible (Tbb or known to resist lysis via an alternative mechanism (Tbr and Tbg group 2. We hypothesize that this single substitution contributes to reduced uptake of TLF and thus may play a key role in conferring serum resistance to Tbg group 1. In contrast, similarity in HpHbR sequence among isolates of Tbg group 2 and Tbb/Tbr provides further evidence that human serum resistance in Tbg group 2 is likely independent of HpHbR function.

  15. Comparison of gadolinium Cy2DOTA, a new hepatobiliary agent, and gadolinium HP-DO3A, an extracellular agent, in healthy liver and metastatic disease

    International Nuclear Information System (INIS)

    Runge, V.M.; Wells, J.W.; Williams, N.M.

    1995-01-01

    A new gadolinium (Gd) chelate with preferential hepatobiliary uptake, Gd Cy 2 DOTA, was compared in two animal species with Gd HP-DO3A (gadoteridol), a clinically approved contrast agent with extracellular distribution. Liver enhancement was evaluated for these two contrast agents using magnetic resonance imaging, whereas an experimental model of metastatic disease was used to evaluate the agents' efficacy for liver-lesion delineation. The two agents were compared in four healthy Rhesus monkeys (eight studies) and five New Zealand White rabbits with implanted VX-2 liver tumors (ten studies). The contrast dose was 0.1 mmol/kg, with the agents given in random order and at least 72 hours between contrast injections. Breathhold T1-weighted spin echo scans were obtained at 1.5 tesla (T) before and after contrast was administered. Postcontrast scans were obtained 1 to 90 minutes after injection in the monkeys and 1 to 240 minutes after injection in the rabbits. Prolonged hepatic enhancement, superior in degree to that with Gd HP-DO3A, was noted to both monkeys and rabbits after injection of Gd Cy 2 DOTA. Two minutes after contrast, liver SI was 1.94 ± 0.05 with Gd Cy 2 DOTA compared with 1.5 ± 0.05 with Gd HP-DO3A in monkeys. Sixty minutes after contrast, liver SI was 1.60 ± 0.09 compared with 1.20 ± 0.02. The difference between agents was significant at all times from 2 to 60 minutes after contrast injection (P 2 DOTA but not with Gd HP-DO3A. The maximum improvement in lesion conspicuity (rabbit) occurred 45 minutes after injection of Gd Cy 2 DOTA and 5 minutes after injection of Gd HP-DO3A. 22 refs., 12 figs

  16. On the computation of FRS

    International Nuclear Information System (INIS)

    Ciucchi, W.; Lazzeri, L.; Olivieri, M.

    1983-01-01

    The problem of the computation of FRS (floor response spectra) is considered and discussed; a procedure is used defining the dynamic input as its power spectral density. A numerical iterative method is used to compute it. Basically three ranges are found: a) light equipment: i.e. the cases in which the feedback action of the equipment on the structure is negligible b) intermediate range: i.e. the cases in which the modes of the structure are not changed, however their amplitude can be changed by the equipment action c) heavy equipments: i.e. the cases in which the modes of the structure are changed by the equipment reactions. (orig./HP)

  17. Tectonic origin of serpentinites on Syros, Greece: Geochemical signatures of abyssal origin preserved in a HP/LT subduction complex

    Science.gov (United States)

    Cooperdock, Emily H. G.; Raia, Natalie H.; Barnes, Jaime D.; Stockli, Daniel F.; Schwarzenbach, Esther M.

    2018-01-01

    This study combines whole rock trace and major element geochemistry, and stable isotope (δD and δ18O) analyses with petrographic observations to deduce the origin and tectonic setting of serpentinization of ultramafic blocks from the exhumed HP/LT Aegean subduction complex on Syros, Greece. Samples are completely serpentinized and are characterized by mineral assemblages that consist of variable amounts of serpentine, talc, chlorite, and magnetite. δD and δ18O values of bulk rock serpentinite powders and chips (δD = - 64 to - 33‰ and δ18O = + 5.2 to + 9.0‰) reflect hydration by seawater at temperatures serpentinization by seawater, followed by secondary fluid-rock interactions with a sedimentary source pre- or syn-subduction. Whole rock major element, trace element, and REE analyses record limited melt extraction, exhibit flat REE patterns, and do not show pronounced Eu anomalies. The geochemical signatures preserved in these serpentinites argue against a mantle wedge source, as has been previously speculated for ultramafic rocks on Syros. Rather, the data are consistent with derivation from abyssal peridotites in a hyper-extended margin setting or mid-ocean ridge and fracture zone environment. In either case, the data suggest an extensional and/or oceanic origin associated with the Cretaceous opening of the Pindos Ocean and not a subduction-related derivation from the mantle wedge.

  18. An Entropy Stable h/p Non-Conforming Discontinuous Galerkin Method with the Summation-by-Parts Property

    KAUST Repository

    Friedrich, Lucas

    2017-12-29

    This work presents an entropy stable discontinuous Galerkin (DG) spectral element approximation for systems of non-linear conservation laws with general geometric (h) and polynomial order (p) non-conforming rectangular meshes. The crux of the proofs presented is that the nodal DG method is constructed with the collocated Legendre-Gauss-Lobatto nodes. This choice ensures that the derivative/mass matrix pair is a summation-by-parts (SBP) operator such that entropy stability proofs from the continuous analysis are discretely mimicked. Special attention is given to the coupling between nonconforming elements as we demonstrate that the standard mortar approach for DG methods does not guarantee entropy stability for non-linear problems, which can lead to instabilities. As such, we describe a precise procedure and modify the mortar method to guarantee entropy stability for general non-linear hyperbolic systems on h/p non-conforming meshes. We verify the high-order accuracy and the entropy conservation/stability of fully non-conforming approximation with numerical examples.

  19. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.

    Science.gov (United States)

    Oikemus, Sarah R; McGinnis, Nadine; Queiroz-Machado, Joana; Tukachinsky, Hanna; Takada, Saeko; Sunkel, Claudio E; Brodsky, Michael H

    2004-08-01

    Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these telomeres suggests that recognition of chromosome ends might contribute to the epigenetic protection of telomeres. In mammals, Ataxia Telangiectasia Mutated (ATM) is activated by DNA damage and acts through an unknown, telomerase-independent mechanism to regulate telomere length and protection. We demonstrate that the Drosophila homolog of ATM is encoded by the telomere fusion (tefu) gene. In the absence of ATM, telomere fusions occur even though telomere-specific Het-A sequences are still present. High levels of spontaneous apoptosis are observed in ATM-deficient tissues, indicating that telomere dysfunction induces apoptosis in Drosophila. Suppression of this apoptosis by p53 mutations suggests that loss of ATM activates apoptosis through a DNA damage-response mechanism. Loss of ATM reduces the levels of heterochromatin protein 1 (HP1) at telomeres and suppresses telomere position effect. We propose that recognition of chromosome ends by ATM prevents telomere fusion and apoptosis by recruiting chromatin-modifying complexes to telomeres.

  20. A high frequency high power IGBT inverter drive for 45 HP/16,000 rpm brushless homopolar inductor motor

    Energy Technology Data Exchange (ETDEWEB)

    He, J.; Lin, F. [Stone Safety Corp., Fountain Inn, SC (United States)

    1995-12-31

    A microprocessor-based ultra-high speed brushless homopolar inductor motor drive system (HiDrive) with no gearing and using a high frequency IGBT inverter switching at 32 kHz is described and discussed in this paper. The homopolar motor features a solid steel rotor without magnets, windings, or laminations, which allows the motor to be operated at very high speed. The HiDrive system achieves 16,000 RPM, 45 Hp continuously. The drive system discussed in this paper can be used to replace conventional motors and speed increasing gear boxes in very high speed industrial applications such as centrifuges, compressors, blowers, pumps, and machine tool spindles. The HiDrive system discussed in this paper is used to drive a compressor for nuclear power application. In this paper, the detailed descriptions of the motor construction, equivalent circuit, operation and control principle are offered. The IGBT inverter drive system design and controls including motor speed sensing, load angle control, synchronization, brake control, power device switchings, and thermal issues are addressed. The simulation results various test results, and the typical application examples of the high speed drives are also presented in this paper.

  1. A high frequency high power IGBT inverter drive for 45 HP/16,000 rpm brushless homopolar inductor motor

    International Nuclear Information System (INIS)

    He, J.; Lin, F.

    1995-01-01

    A microprocessor-based ultra-high speed brushless homopolar inductor motor drive system (HiDrive) with no gearing and using a high frequency IGBT inverter switching at 32 kHz is described and discussed in this paper. The homopolar motor features a solid steel rotor without magnets, windings, or laminations, which allows the motor to be operated at very high speed. The HiDrive system achieves 16,000 RPM, 45 Hp continuously. The drive system discussed in this paper can be used to replace conventional motors and speed increasing gear boxes in very high speed industrial applications such as centrifuges, compressors, blowers, pumps, and machine tool spindles. The HiDrive system discussed in this paper is used to drive a compressor for nuclear power application. In this paper, the detailed descriptions of the motor construction, equivalent circuit, operation and control principle are offered. The IGBT inverter drive system design and controls including motor speed sensing, load angle control, synchronization, brake control, power device switchings, and thermal issues are addressed. The simulation results various test results, and the typical application examples of the high speed drives are also presented in this paper

  2. The 2H(p,2p)n reaction at 508 MeV. Part I

    International Nuclear Information System (INIS)

    Punjabi, V.; Perdrisat, C.F.; Aniol, K.A.; Epstein, M.B.; Huber, J.P.; Margaziotis, D.J.; Bracco, A.; Davis, C.A.; Gubler, H.P.; Lee, W.P.; Poffenberger, P.R.; van Oers, W.T.H.; Postma, H.; Sebel, H.J.; Stetz, A.W.

    1988-09-01

    Differential cross sections for the reaction 2 H(p,2p)n at T p = 507 and 508 MeV are presented. The proton angle pairs chosen were 41.5 degrees with 41.4 and 50.0, 30.1 degrees with 44.0, 53,75, 61.0, and 68.0, 38.1 degrees -38.0 degrees, 44.1 degrees - 44.0 degrees, 47.1 degrees - 47.0 degrees and 50.0 degrees - 50.0 degrees. The data range over an energy window 100 MeV wide on one of the proton energies, the second energy being defined by the kinematic condition of a single neutron recoiling. The data are compared with the impulse approximation (IA) prediction and with the results of a nonrelativistic calculation of the six lowest-order Feynman diagrams describing the reaction. A previously known missing strength for the reaction in the small neutron recoil region is confirmed with much smaller experimental uncertainty; the missing strength persists up to 150 MeV/c neutron recoil. The onset of a systematic section excess relative to the IA near neutron recoil momentum 200 MeV is explored in detail. (Author) (37 refs., 17 figs.)

  3. Intercomparison of measurements of personal dose equivalent Hp(10) in photon fields in the West Asia Region

    International Nuclear Information System (INIS)

    2007-01-01

    In accordance with its statutory function, the International Atomic Energy Agency (IAEA) has been assisting its Member States in establishing and upgrading their radiation protection infrastructures, including activities in occupation radiation protection. Individual external dosimetry services for photon radiation have been under establishment or upgrading with support through the Technical Cooperation Model Projects RAW/9/006, Upgrading Radiation Protection Infrastructure (concluded in 2000), and RAW/9/008, Development of Technical Capabilities for Sustainable Radiation and Waste Safety Infrastructure (2001-2004), in all the participating countries in the West Asia Region. Two regional training courses were organized by the IAEA, in Germany in 1998, on Design, Implementation and Management of Individual Monitoring Services (IMS), and in the Syrian Arabic Republic in 2001, on Assessment of Occupational Exposure due to External Sources, under the above stated projects. However, no performance testing has yet been carried out and no regional intercomparisons have been established before in this region. Only two Member States from the region (the Syrian Arab Republic and Lebanon) participated in the interregional Intercomparison for Individual Monitoring of Radiological Measurements for Purposes of Monitoring Personal Dose Equivalent Hp(10) in 1999

  4. Switching strategy between HP (high pressure)- and LPEGR (low pressure exhaust gas recirculation) systems for reduced fuel consumption and emissions

    International Nuclear Information System (INIS)

    Luján, José Manuel; Guardiola, Carlos; Pla, Benjamín; Reig, Alberto

    2015-01-01

    EGR (Exhaust gas recirculation) plays a major role in current Diesel internal combustion engines as a cost-effective solution to reduce NO_x emissions. EGR systems will suffer a significant evolution with the introduction of NO_x after-treatment and the proliferation of more complex EGR architectures such as low pressure EGR or dual EGR. In this paper the combination of HPEGR (high pressure EGR) LPEGR (low pressure EGR) is presented as a method to minimise fuel consumption with reduced NO_x emissions. Particularly, the paper proposes to switch between HPEGR and LPEGR architectures depending on the engine operating conditions in order to exploit the potential of both systems. In this sense, given a driving cycle, in the case at hand the NEDC, the proposed strategy seeks the EGR layout to use at each instant of the cycle to minimise the fuel consumption such that NO_x emissions are kept below a certain limit. The experimental results obtained show that combining both EGR systems sequentially along the NEDC allows to keep NO_x emission below a much lower limit with minimum fuel consumption. - Highlights: • The combination of HP–LPEGR reduces the NO_x with a small impact on consumption. • The switching strategy between HP – LPEGR is derived from Optimal Control Theory. • The proposed strategy is validated experimentally.

  5. An Analysis of the Constitutional Court Ruling on the Annulment of the Provisions on Coastal Water Concessions (HP-3

    Directory of Open Access Journals (Sweden)

    M. Riza Damanik

    2013-05-01

    Full Text Available After the annulment of the Coastal Water Concessions (HP-3 in 16 June 2011, traditional fisher folk organization leaders found a great fighting spirit to further follow-up the Constitutional Court Ruling to support their daily lives. For those who are being “evicted” from their living space (the coastal waters, they want to reclaim their rights through constitutional ways. Likewise, those who (feel to have lost their existence as Indonesian traditional fisher folk are impatient to find out whether there is a breakthrough in the Constitutional Court Ruling that can restore the fisher folk’s family way of life. The ruling itself was complex and not easy to understand: 169 pages, with complex writing systematic and typical legal language. For this reason, the analysis of the Constitutional Court Ruling regarding the Judicial Review on Law No. 27 of 2007 on the Management of Coastal Areas and Small Islands was necessary in order to provide a simpler representation of the Constitutional Court Ruling, and one that is expected to trigger a constructive discussion to implement the favorable parts of the decree for the greatest welfare of the people.

  6. KIVA-hpFE: Predictive turublent reactive and multiphase flow in engines : Science Supporting Mission of the Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Carrington, David Bradley [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Waters, Jiajia [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-26

    Research and development of KIVA-hpFE for turbulent reactive and multiphase flow particularly as related to engine modeling program has relevance to National energy security and climate change. Climate change is a source problem, and energy national security is consumption of petroleum products problem. Accurately predicting engine processes leads to, lower greenhouse gas (GHG) emission, where engines in the transportation sector currently account for 26% of the U.S. GHG emissions. Less dependence on petroleum products leads to greater energy security. By Environmental Protection Agency standards, some vehicles are now reaching 42 to the 50 mpg mark. These are conventional gasoline engines. Continued investment and research into new technical innovations, the potential exists to save more than 4 million barrels of oil per day or approximately $200 to $400 million per day. This would be a significant decrease in emission and use of petroleum and a very large economic stimulus too! It is estimated with further advancements in combustion, the current emissions can be reduced up to 40%. Enabling better understanding of fuel injection and fuel-air mixing, thermodynamic combustion losses, and combustion/emission formation processes enhances our ability to help solve both problems. To provide adequate capability for accurately simulating these processes, minimize time and labor for development of engine technology, are the goals of our KIVA development program.

  7. Tensile and electrical properties of unirradiated and irradiated Hycon 3HP{trademark} CuNiBe

    Energy Technology Data Exchange (ETDEWEB)

    Zinkle, S.J.; Eatherly, W.S. [Oak Ridge National Lab., TN (United States)

    1996-10-01

    The unirradiated tensile properties of two different heats of Hycon 3HP{trademark} CuNiBe (HT Temper) have been measured over the temperature range of 20-500{degrees}C for longitudinal and long transverse orientations. The room temperature electrical conductivity has also been measured for both heats. Both heats exhibited a very good combination of strength and conductivity at room temperature. The strength remained relatively high at all test temperatures, with a yield strength of 420-520 MPa at 500{degrees}C. However, low levels of ductility (<5% uniform elongation) were observed at test temperatures above 200-250{degrees}C, due to flow localization adjacent to grain boundaries. Fission neutron irradiation to a dose of {approximately}0.7 dpa at temperatures between 100 and 240{degrees}C produced a slight increase in strength and a significant decrease in ductility. The measured tensile elongation increased with increasing irradiation temperature, with a uniform elongation of {approximately}3.3% observed at 240{degrees}C. The electrical conductivity decreased slightly following irradiation, due to the presence of defect clusters and Ni, Zn, Co transmutation products. The data indicate that CuNiBe alloys have irradiated tensile and electrical properties comparable or superior to CuCrZr and oxide dispersion strengthened copper at temperatures <250{degrees}C, and may be suitable for certain fusion energy structural applications.

  8. BAGAIMANA MENENTUKAN SLIP PADA TRANSMISI PULLEY & V-BELT PADA BEBAN TERTENTU DENGAN MENGGUNAKAN MOTOR BERDAYA Hp

    Directory of Open Access Journals (Sweden)

    syafrizal syafrizal

    2017-04-01

    Full Text Available Tidak banyak para teknisi menggunakan transmisi putaran pada mesin dari satu poros ke poros yang lain memperhitungkan adanya slip antara poros dengan transmisi, sehingga putaran ouput poros yang diharapkan tidak tercapai. Seperti yang ditunjukkan pada transmisi pulley dan v-belt, pada pulley dan v-belt bahwa putaran output yang disampaikan pada pulley akan terjadi penurunan nilai putaran beberapa persen karena timbul slip antara belt dengan pulley. Penurunan nilai putaran tersebut akan bertambah dengan bertambahnya massa putaran yang dibawa. Dalam penelitian ini penulis menggunakan motor Hp dan putara 1410 rpm, pulley dan v-belt dengan koefisien gesk sebesar = 0,3. Secara analisa teoritis dengan memilih faktor kritis 1,056 maka nilai putaran tersebut akan berubah sebesar , dengan rasio putaran pulley sebesar i = 2,953216. Ketika dilakukan pengujian dengan beban massa 1,707 kg maka putaran poros motor diperoleh sebesar 1489 rpm, dengan menggunakan rasio putaran maka putaran pulley output sebesar 504,2 rpm, tetapi pada pengukuran putaran pulley sebesar 497,35 rpm, sehingga menimbulkan selisih sebesar 6,9 rpm atau mengalami slip sebesar 1,39 %, dan nilai ini akan terus bertambah dengan bertambahnya beban massa putar yang dibawa. Berdasar analisa empiris besarnya slip dengan menggunakan program excel, maka didapatlah persamaan hubungan persentase slip dengan perubahan massa yang dipakai seperti; .

  9. Collection and analysis of environmental radiation data using a desktop computer

    International Nuclear Information System (INIS)

    Gogolak, C.V.

    1982-04-01

    A portable instrumentation sytem using a Hewlett-Packard HP-9825 desktop computer for the collection and analysis of environmental radiation data is described. Procedures for the transmission of data between the HP-9825 and various nuclear counters are given together with a description of the necessary hardware and software. Complete programs for the analysis of Ge(Li) and NaI(Tl) gamma-ray spectra, high pressure ionization chamber monitor data, 86 Kr monitor data and air filter sample alpha particle activity measurements are presented. Some utility programs, intended to increase system flexibility, are included

  10. Comparative evaluation of electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) and high-pH reversed phase (Hp-RP) chromatography in profiling of rat kidney proteome.

    Science.gov (United States)

    Hao, Piliang; Ren, Yan; Dutta, Bamaprasad; Sze, Siu Kwan

    2013-04-26

    ERLIC and high-pH RP (Hp-RP) have been reported to be promising alternatives to strong cation exchange (SCX) in proteome fractionation. Here we compared the performance of ERLIC, concatenated ERLIC and concatenated Hp-RP in proteome profiling. The protein identification is comparable in these three strategies, but significantly more unique peptides are identified by the two concatenation methods, resulting in a significant increase of the average protein sequence coverage. The pooling of fractions from spaced intervals results in more uniform distribution of peptides in each fraction compared with the chromatogram-based pooling of adjacent fractions. ERLIC fractionates peptides according to their pI and GRAVY values. These properties remains but becomes less remarkable in concatenated ERLIC. In contrast, the average pI and GRAVY values of the peptides are comparable in each fraction in concatenated Hp-RP. ERLIC performs the best in identifying peptides with pI>9 among the three strategies, while concatenated Hp-RP is good at identifying peptides with pI<4. These advantages are useful when either basic or acidic peptides/proteins are analytical targets. The power of ERLIC in identification of basic peptides seems to be due to their efficient separation from acidic peptides. This study facilitates the choice of proper fractionation strategies based on specific objectives. For in-depth proteomic analysis of a cell, tissue and plasma, multidimensional liquid chromatography (MDLC) is still necessary to reduce sample complexity for improving analytical dynamic range and proteome coverage. This work conducts a direct comparison of three promising first-dimensional proteome fractionation methods. They are comparable in identifying proteins, but concatenated ERLIC and concatenated Hp-RP identify significantly more unique peptides than ERLIC. ERLIC is good at analyzing basic peptides, while concatenated Hp-RP performs the best in analyzing acidic peptides with pI<4. This

  11. The Role of Standards in Cloud-Computing Interoperability

    Science.gov (United States)

    2012-10-01

    services are not shared outside the organization. CloudStack, Eucalyptus, HP, Microsoft, OpenStack , Ubuntu, and VMWare provide tools for building...center requirements • Developing usage models for cloud ven- dors • Independent IT consortium OpenStack http://www.openstack.org • Open-source...software for running private clouds • Currently consists of three core software projects: OpenStack Compute (Nova), OpenStack Object Storage (Swift

  12. HP 2671G GRAPHICS

    CERN Multimedia

    1981-01-01

    The 2671 was a text-only printer with a maximum print speed of 120 characters per second. The 2671 printers are very robust. For paper, they use normal thermal roll paper sold in most office supply stores for older fax machines. Although thermal printing is a quiet technology, the paper advance mechanism of these printers is plenty loud.

  13. HP Vertica essentials

    CERN Document Server

    Agrawal, Rishabh

    2014-01-01

    This is a step-by-step guide with an easy-to-follow approach. A variety of diagrams and images support the concepts explored in the book. This book also contains important tips and tricks, thus making it a really useful reference for Vertica administration activities.If you are a Vertica user or DBA who wants to perform basic administration and fine tuning, this book is for you. Prior knowledge of Vertica will help you to understand the concepts better, but is not mandatory. Some intermediate knowledge of RDBMS, SQL, Linux, and scripting languages such as Perl or Python will be helpful.

  14. Helicobacter pylori Outer Membrane Protein 18 (Hp1125 Is Involved in Persistent Colonization by Evading Interferon-γ Signaling

    Directory of Open Access Journals (Sweden)

    Yuqun Shan

    2015-01-01

    Full Text Available Outer membrane proteins (OMPs can induce an immune response. Omp18 (HP1125 of H. pylori is a powerful antigen that can induce significant interferon-γ (IFN-γ levels. Previous studies have suggested that IFN-γ plays an important role in H. pylori clearance. However, H. pylori has multiple mechanisms to avoid host immune surveillance for persistent colonization. We generated an omp18 mutant (H. pylori 26695 and H. pylori SS1 strain to examine whether Omp18 interacts with IFN-γ and is involved in H. pylori colonization. qRT-PCR revealed that IFN-γ induced Omp18 expression. qRT-PCR and western blot analysis revealed reduced expressions of virulence factors CagA and NapA in H. pylori 26695 with IFN-γ treatment, but they were induced in the Δomp18 strain. In C57BL/6 mice infected with H. pylori SS1 and the Δomp18 strain, the Δomp18 strain conferred defective colonization and activated a stronger inflammatory response. Signal transducer phosphorylation and transcription 1 (STAT1 activator was downregulated by the wild-type strain but not the Δomp18 strain in IFN-γ-treated macrophages. Furthermore, Δomp18 strain survival rates were poor in macrophages compared to the wild-type strain. We concluded that H. pylori Omp18 has an important function influencing IFN-γ-mediated immune response to participate in persistent colonization.

  15. SRC burn test in 700-hp oil-designed boiler. Annex Volume C. Boiler emission report. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    1983-09-01

    The Solvent-Refined Coal (SRC) test burn program was conducted at the Pittsburgh Energy Technology Center (PETC) located in Bruceton, Pa. One of the objectives of the study was to determine the feasibility of burning SRC fuels in boilers set up for fuel oil firing and to characterize emissions. Testing was conducted on the 700-hp oil-fired boiler used for research projects. No. 6 fuel oil was used for baseline data comparison, and the following SRC fuels were tested: SRC Fuel (pulverized SRC), SRC Residual Oil, and SRC-Water Slurry. Uncontrolled particulate emission rates averaged 0.9243 lb/10/sup 6/ Btu for SRC Fuel, 0.1970 lb/10/sup 6/ Btu for SRC Residual Oil, and 0.9085 lb/10/sup 6/ Btu for SRC-Water Slurry. On a lb/10/sup 6/ Btu basis, emissions from SRC Residual Oil averaged 79 and 78%, respectively, lower than the SRC Fuel and SRC-Water Slurry. The lower SRC Residual Oil emissions were due, in part, to the lower ash content of the oil and more efficient combustion. The SRC Fuel had the highest emission rate, but only 2% higher than the SRC-Water Slurry. Each fuel type was tested under variable boiler operating parameters to determine its effect on boiler emissions. The program successfully demonstrated that the SRC fuels could be burned in fuel oil boilers modified to handle SRC fuels. This report details the particulate emission program and results from testing conducted at the boiler outlet located before the mobile precipitator take-off duct. The sampling method was EPA Method 17, which uses an in-stack filter.

  16. Monocrotophos, an organophosphorus insecticide, disrupts the expression of HpNetrin and its receptor neogenin during early development in the sea urchin (Hemicentrotus pulcherrimus).

    Science.gov (United States)

    Zhang, Xiaona; Xu, Lei; Tian, Hua; Wang, Cuicui; Wang, Wei; Ru, Shaoguo

    2017-09-01

    Netrins, chemotropic guidance cues, can guide the extension of serotonergic axons by binding to netrin receptors during neural development. However, little is known about whether disruption of netrin signaling is involved in the mechanisms by which organophosphorus pesticides affect serotonergic nervous system (SNS) development. In this study, we evaluated the effects of the pesticide monocrotophos (MCP) on the expression patterns of HpNetrin and its receptor neogenin as well as on the intracellular calcium ion (Ca 2+ ) levels in Hemicentrotus pulcherrimus (sea urchin) by exposing fertilized embryos to 0, 0.01, 0.10, and 1.00mg/L MCP. The results showed that MCP disrupted HpNetrin and neogenin expression at different developmental stages in H. pulcherrimus and that Ca 2+ appeared to be involved in the MCP-induced developmental neurotoxicity. Specifically, the lower concentrations of MCP elevated HpNetrin and neogenin transcription, resulting in higher intracellular Ca 2+ levels during the early developmental stages in the sea urchin; this may affect netrin-directed cell migration/axon extension and subsequently disrupt serotonergic axon branching and synapse formation. In contrast, 1.00mg/L MCP exhibited an inhibitory effect on HpNetrin and neogenin transcription. This finding implies that the regulatory roles of these factors may be diminished during early development, thereby causing developmental defects in the sea urchin. Collectively, our results provide a basis for exploring the involvement of netrin and neogenin in the organophosphate-induced disruption of the SNS during development. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Determination of the approximate number of welding qualification procedures, according to the AD-HP 2/1 and NUCLEN rules

    International Nuclear Information System (INIS)

    Couto, J.G.V.

    1986-01-01

    The simple equations based on the phylosophy of AD-HP 2/1 which determine the approximate number welding qualification procedures for the manufacture either of one component, or several components requested simultaneously are presented. It is also intended to help the manufacturer in the rational preparation of scheduling the required minimum qualifications for performing the work, including giving him an idea about the involved costs which the firm will have to bear in this phase prior to manufacturing. (Author) [pt

  18. Corrosion by sulfate-reducing bacteria in a HP gas line under a detached weld cladding; Korrosion durch sulfatreduzierende Bakterien an einer Hochdruckgasleitung unter abgeloester Schweissnahtnachumhuellung

    Energy Technology Data Exchange (ETDEWEB)

    Bette, Ulrich [Technische Akademie Wuppertal (Germany)

    2011-07-01

    Intelligent pig measurements detected several points of corrosion in a HP gas pipeline in northern Germany. Corrosion occurred in a pipe section buried in clay soil, under detached weld claddings. It was not detected in regular measurements and additional intensive measurements. When the pipes were dug up, sulfate-reducing bacteria were found as the cause of corrosion. Due to the location of the corrosion processes, cathodic protection was impossible, and IFO measurements were ineffective in the low-ohmic soil.

  19. Measuring techniques in emission computed tomography

    International Nuclear Information System (INIS)

    Jordan, K.; Knoop, B.

    1988-01-01

    The chapter reviews the historical development of the emission computed tomography and its basic principles, proceeds to SPECT and PET, special techniques of emission tomography, and concludes with a comprehensive discussion of the mathematical fundamentals of the reconstruction and the quantitative activity determination in vivo, dealing with radon transformation and the projection slice theorem, methods of image reconstruction such as analytical and algebraic methods, limiting conditions in real systems such as limited number of measured data, noise enhancement, absorption, stray radiation, and random coincidence. (orig./HP) With 111 figs., 6 tabs [de

  20. The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2.

    Science.gov (United States)

    Bugga, Lakshmi; McDaniel, Ivy E; Engie, Liana; Armstrong, Jennifer A

    2013-01-01

    CHD1 is a conserved chromatin remodeling factor that localizes to active genes and functions in nucleosome assembly and positioning as well as histone turnover. Mouse CHD1 is required for the maintenance of stem cell pluripotency while human CHD1 may function as a tumor suppressor. To investigate the action of CHD1 on higher order chromatin structure in differentiated cells, we examined the consequences of loss of CHD1 and over-expression of CHD1 on polytene chromosomes from salivary glands of third instar Drosophila melanogaster larvae. We observed that chromosome structure is sensitive to the amount of this remodeler. Loss of CHD1 resulted in alterations of chromosome structure and an increase in the heterochromatin protein HP1a, while over-expression of CHD1 disrupted higher order chromatin structure and caused a decrease in levels of HP1a. Over-expression of an ATPase inactive form of CHD1 did not result in severe chromosomal defects, suggesting that the ATPase activity is required for this in vivo phenotype. Interestingly, changes in CHD1 protein levels did not correlate with changes in the levels of the euchromatin mark H3K4me3 or elongating RNA Polymerase II. Thus, while CHD1 is localized to transcriptionally active regions of the genome, it can function to alter the levels of HP1a, perhaps through changes in methylation of H3K9.

  1. The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2.

    Directory of Open Access Journals (Sweden)

    Lakshmi Bugga

    Full Text Available CHD1 is a conserved chromatin remodeling factor that localizes to active genes and functions in nucleosome assembly and positioning as well as histone turnover. Mouse CHD1 is required for the maintenance of stem cell pluripotency while human CHD1 may function as a tumor suppressor. To investigate the action of CHD1 on higher order chromatin structure in differentiated cells, we examined the consequences of loss of CHD1 and over-expression of CHD1 on polytene chromosomes from salivary glands of third instar Drosophila melanogaster larvae. We observed that chromosome structure is sensitive to the amount of this remodeler. Loss of CHD1 resulted in alterations of chromosome structure and an increase in the heterochromatin protein HP1a, while over-expression of CHD1 disrupted higher order chromatin structure and caused a decrease in levels of HP1a. Over-expression of an ATPase inactive form of CHD1 did not result in severe chromosomal defects, suggesting that the ATPase activity is required for this in vivo phenotype. Interestingly, changes in CHD1 protein levels did not correlate with changes in the levels of the euchromatin mark H3K4me3 or elongating RNA Polymerase II. Thus, while CHD1 is localized to transcriptionally active regions of the genome, it can function to alter the levels of HP1a, perhaps through changes in methylation of H3K9.

  2. Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA.

    Directory of Open Access Journals (Sweden)

    Martin Löwer

    Full Text Available Exported proteases of Helicobacter pylori (H. pylori are potentially involved in pathogen-associated disorders leading to gastric inflammation and neoplasia. By comprehensive sequence screening of the H. pylori proteome for predicted secreted proteases, we retrieved several candidate genes. We detected caseinolytic activities of several such proteases, which are released independently from the H. pylori type IV secretion system encoded by the cag pathogenicity island (cagPAI. Among these, we found the predicted serine protease HtrA (Hp1019, which was previously identified in the bacterial secretome of H. pylori. Importantly, we further found that the H. pylori genes hp1018 and hp1019 represent a single gene likely coding for an exported protein. Here, we directly verified proteolytic activity of HtrA in vitro and identified the HtrA protease in zymograms by mass spectrometry. Overexpressed and purified HtrA exhibited pronounced proteolytic activity, which is inactivated after mutation of Ser205 to alanine in the predicted active center of HtrA. These data demonstrate that H. pylori secretes HtrA as an active protease, which might represent a novel candidate target for therapeutic intervention strategies.

  3. Structure of trihydrated rare-earth acid diphosphates LnHP2O7·3H2O (Ln=La, Er)

    International Nuclear Information System (INIS)

    Ben Moussa, S.; Ventemillas, S.; Cabeza, A.; Gutierrez-Puebla, E.; Sanz, J.

    2004-01-01

    In trihydrated lanthanum acid-diphosphates LnHP 2 O 7 ·3H 2 O, prepared from acid LnCl 3 and Na 4 P 2 O 7 solutions (pH=1), two crystal forms were obtained. Layered structures of two representative members of this family have been determined by single-crystal X-ray diffraction (XRD) technique. In the case of orthorhombic LaHP 2 O 7 ·3H 2 O (type I), lanthanum cations are ninefold coordinated and diphosphate groups adopt a staggered (alternated) configuration. In the case of triclinic ErHP 2 O 7 ·3H 2 O (type II), erbium cations are eightfold coordinated and diphosphate groups adopt an eclipsed configuration. In agreement with Infrared (IR) spectroscopic data, a bended configuration for diphosphate groups has been deduced. In both structures, one-dimensional chains of edge-sharing rare-earth polyhedra are linked together by diphosphate groups to form the phosphate layers. In both diphosphates, PO 4 and HPO 4 environments have been identified by 31 P MAS-NMR technique. In the two compounds, OH groups of HPO 4 tetrahedra point out of diphosphate planes interacting with adjacent layers. In La-diphosphate, the interaction between HPO 4 groups and water molecules of adjacent layers is favored; however, in Er-diphosphate, the interaction between phosphate acid groups of contiguous layers is produced. Based on structural information deduced, differences detected in IR and NMR spectra of two disphosphates are discussed

  4. Computing and Network - Overview

    International Nuclear Information System (INIS)

    Jakubowski, Z.

    1999-01-01

    Full text: The responsibility of the Network Group covers: - providing central services like WWW, DNS (Domain Name Server), mail, etc.; - maintenance and support of the Local Area Networks,; - operation of the Wide Area Networks (LAN); - the support of the central UNIX servers and desktop workstations; - VAX/VMS cluster operation and support. The two-processor HP-UNIX K-200 and 6-processor SGI Challenge XL servers were delivering stable services to our users. Both servers were upgraded during the past year. SGI Challenge received additional 256 MB of memory. It was necessary in order to get all benefits of true 64-bit architecture of the SGI IRIX 6.2. The upgrade of our HP K-200 server were problematic so we decided to buy a new powerful machine and join the old and new machine via the fast network. Besides these main servers we have more than 30 workstations from IBM, DEC, HP, SGI and SUN. We observed a real race in PC technology in the past year. Intel processors deliver currently a performance that is comparable with HP or SUN workstations at very low costs. These CPU power is especially visible under Linux that is free Unix-like operating system. The clusters of cheap PC computers should be seriously considered in planning the computing power for the future experiments. The CPU power was further decentralized-smaller but powerful computers cover growing computing demands of our work-groups creating a small ''local computing centers''. The stable network and the concept of central services plays the essential role in this scenario. Unfortunately the network performance for the international communications is persistently unacceptable. We believe that attempts to join the European Quantum project is the only way to achieve the reasonable international network performance. In these plan polish scientific community will gain 34 Mbps international link. The growing costs of the ''real meetings'' give us no alternative to ''virtual meetings'' via the network in the

  5. TMX-U computer system in evolution

    International Nuclear Information System (INIS)

    Casper, T.A.; Bell, H.; Brown, M.; Gorvad, M.; Jenkins, S.; Meyer, W.; Moller, J.; Perkins, D.

    1986-01-01

    Over the past three years, the total TMX-U diagnsotic data base has grown to exceed 10 megabytes from over 1300 channels; roughly triple the originally designed size. This acquisition and processing load has resulted in an experiment repetition rate exceeding 10 minutes per shot using the five original Hewlett-Packard HP-1000 computers with their shared disks. Our new diagnostics tend to be multichannel instruments, which, in our environment, can be more easily managed using local computers. For this purpose, we are using HP series 9000 computers for instrument control, data acquisition, and analysis. Fourteen such systems are operational with processed format output exchanged via a shared resource manager. We are presently implementing the necessary hardware and software changes to create a local area network allowing us to combine the data from these systems with our main data archive. The expansion of our diagnostic system using the paralled acquisition and processing concept allows us to increase our data base with a minimum of impact on the experimental repetition rate

  6. A proposal for a test method for assessment of hazard property HP 12 (“Release of an acute toxic gas”) in hazardous waste classification - Experience from 49 waste

    OpenAIRE

    Hennebert , Pierre; Samaali , Ismahen; Molina , Pauline

    2016-01-01

    International audience; A stepwise method for assessment of the HP 12 is proposed and tested with 49 waste samples. The hazard property HP 12 is defined as “Release of an acute toxic gas”: waste which releases acute toxic gases (Acute Tox. 1, 2 or 3) in contact with water or an acid. When a waste contains a substance assigned to one of the following supplemental hazards EUH029, EUH031 and EUH032, it shall be classified as hazardous by HP 12 according to test methods or guidelines (EC, 2014a, ...

  7. Speed test results and hardware/software study of computational speed problem, appendix D

    Science.gov (United States)

    1984-01-01

    The HP9845C is a desktop computer which is tested and evaluated for processing speed. A study was made to determine the availability and approximate cost of computers and/or hardware accessories necessary to meet the 20 ms sample period speed requirements. Additional requirements were that the control algorithm could be programmed in a high language and that the machine have sufficient storage to store the data from a complete experiment.

  8. Simulation and thermoeconomic analysis of different configurations of gas turbine (GT)-based dual-purpose power and desalination plants (DPPDP) and hybrid plants (HP)

    International Nuclear Information System (INIS)

    Rensonnet, Thibaut; Uche, Javier; Serra, Luis

    2007-01-01

    This paper contains a simulation and a thermoeconomic analysis of several configurations of gas turbine (GT)-based dual-purpose power and desalination plants (DPPDP): Gas turbine with reverse osmosis (GT+RO), combined cycle with reverse osmosis (CC+RO), combined cycle with multi-effect distillation (CC+MED) and two different hybrid plant (HP) arrangements combining CC, MED and RO (CC+MED+RO, CC+MED+RO bis ). The last two configurations only differ from the feed solution to the MED units (raw seawater or brine coming from the RO discharge). A complete thermodynamic simulation at both design and at part load conditions has been made, as well as an exergy and an exergo-economic (thermoeconomic) analysis of each configuration, in order to compare the evolution of the water and electricity cost for different arrangements. The results show that even for a significantly reduced fuel cost (1.42 $/GJ), the CC is much more profitable than a GT operating in open cycle, with electricity cost values of 1.647 and 2.166 c$/kWh, respectively. As was expected, RO is more efficient and profitable than MED desalination processes, the difference in the obtained desalted water cost being significant. In the hybrid configuration with MED fed by the RO brine discharge, a decrease in the equivalent electrical consumption of nearly 2 kWh/m 3 was achieved, but even in this case RO was more efficient (14.15 vs. 4.048 kWh/m 3 ). The evolution of electricity cost in each configuration is more similar at part load operation than at full load, but in the case of water cost, RO is once again more profitable and less sensitive to load variations. Costs given in this paper correspond to investment and fuel costs. Further, profitability and operation strategies of HP, i.e., DPPDP combining distillation and membrane processes, are also analyzed. It is shown that HP can be more profitable than RO plants in the case of increasing the water production capacity of existing DPPDP, because the profit

  9. 2H(p, pp) n reaction as a probe of the short-range nuclear force

    International Nuclear Information System (INIS)

    Haftel, M.I.; Petersen, E.L.; Wallace, J.M.

    1976-01-01

    We examine the feasibility of using the 2 H(p, pp) n reaction as a means of extracting information about the short-range behavior of the nuclear force not obtainable from N-N scattering experiments. To do this we use several separable potentials and examine the predicted cross section in various regions of phase space and for beam energies between 14 and 65 MeV. The questions that we address are likely to be insensitive to Coulomb effects. Both the form factor and the energy dependence of the potentials have been modified from the usual Yamaguchi form. The form of the energy dependence is chosen to obtain phase-shift equivalence for two different form factors while guaranteeing a unitary two-body scattering amplitude. The sensitivity of breakup results to the on-shell and off-shell aspects of the nuclear force is examined and discussed. Significant on-shell sensitivity occurs for breakup amplitudes in all states and for cross sections over all regions of phase space. Off-shell sensitivity appears only in the S = 1/2, L = 0 breakup amplitudes, with all S = 3/2 and all L > 0 amplitudes exhibiting negligible off-shell dependence. This result leads to only a very small (< or = 5%) off-shell sensitivity for quasifree scattering. However, cross sections far from quasifree scattering, and in particular cross sections in the final-state interaction region of phase space, exhibit as much as a 50% variation for phase-shift-equivalent potentials. This sensitivity is small at low beam energy and increases with increasing energy. The energy dependence at negative energies of one potential is also altered to adjust the triton binding energy. This enables us to compare phase-shift-equivalent potentials differing off shell but predicting the same triton binding energy. The energy dependence of this potential is somewhat unconventional. Fixing of the triton binding energy reduces the off-shell sensitivity appreciably only for E approximately-less-than 20 MeV

  10. Results of the regional intercomparison exercise for the determination of operational quantity Hp(d) in Latin America

    International Nuclear Information System (INIS)

    Saravi, M.; Zaretzky, A.; Lindner, C.; Diaz, J.; Walwyn, G.; Souza, D.; Amorin, R.; Gregory, B.; Papadopulos, S.; Meghzifene, A.; Ferruz Cruz, P.; Cruz Suarez, R.

    2005-01-01

    Full text: Several intercomparison exercises were organized by the International Atomic Energy Agency (IAEA) on the determination of operational quantities at the regional or interregional basis. These exercises revealed significant differences in the approach, methods and assumptions, and consequently in the measurement results obtained by participating laboratories. In the Latin America region, an intercomparison for determination of operational quantity Hp(10), organized within the frame of a technical cooperation regional project, was completed mid-2004, as a follow-up to previous exercises carried out during the 1990s. Eighteen laboratories from 19 member states participated in the first phase; the second phase grouped 15 laboratories from 16 member states. Dosimeter irradiations (5 different radiation qualities for photon simulating workplace fields) were done by 4 Secondary Standards Dosimetry Laboratories (SSDL). The preparations for the exercise involved an audit by the IAEA SSDL, where reference irradiations were provided to all participants for verification of their system. During the first phase (2002/03), only 9 out of 18 laboratories met the performance requirements for such monitoring services. Necessary corrective actions and procedure verification were implemented, and staff involved in these evaluations were subsequently trained. During the second phase (2004), 11 out of 15 laboratories fulfilled the performance criteria. The 4 laboratories still having difficulties in assessing occupational exposure participated in a results meeting, during which problem areas were identified. An ongoing technical cooperation mission is expected to assist these laboratories accordingly. There has been a definite improvement in the second phase and most laboratories demonstrated a good performance in the quantity tested. The technical results clearly show that the laboratories' capability in assessing occupational exposure from external sources of radiation is

  11. A computational procedure for coupled electromagnetic-structural dynamic problems and its application to a fusion reactor blanket

    International Nuclear Information System (INIS)

    Jordan, T.

    1993-09-01

    A method is presented in order to couple quasistationary electromagnetics and the dynamics of structure and fluid. This method allows to compute forces, strains and stresses in structures subjected to transient magnetic fields. An important application was to determine the dynamic loading of the self-cooled liquid metal blanket during a plasma distruption. (orig./HP) [de

  12. Radioimmunoassay data processing program for IBM PC computers

    International Nuclear Information System (INIS)

    1989-06-01

    The Medical Applications Section of the International Atomic Energy Agency (IAEA) has previously developed several programs for use on the Hewlett-Packard HP-41C programmable calculator to facilitate better quality control in radioimmunoassay through improved data processing. The program described in this document is designed for off-line analysis using an IBM PC (or compatible) for counting data from standards and unknown specimens (i.e. for analysis of counting data previously recorded by a counter), together with internal quality control (IQC) data both within and between batch. The greater computing power of the IBM PC has enabled the imprecision profile and IQC control curves which were unavailable on the HP-41C version. It is intended that the program would make available good data processing capability to laboratories having limited financial resources and serious problems of quality control. 3 refs

  13. HP-CsB{sub 5}O{sub 8}. Synthesis and characterization of an outstanding borate exhibiting the simultaneous linkage of all structural units of borates

    Energy Technology Data Exchange (ETDEWEB)

    Sohr, Gerhard; Huppertz, Hubert [Institut fuer Allgemeine, Anorganische und Theoretische Chemie, Leopold-Franzens-Universitaet Innsbruck (Austria); Toebbens, Daniel M. [Helmholtz-Zentrum Berlin fuer Materialien und Energie GmbH, Berlin (Germany); Schmedt auf der Guenne, Joern [Department fuer Chemie/Biologie, Universitaet Siegen (Germany)

    2014-12-15

    The new cesium pentaborate HP-CsB{sub 5}O{sub 8} is synthesized under high-pressure/high-temperature conditions of 6 GPa and 900 C in a Walker-type multianvil apparatus. The compound crystallizes in the orthorhombic space group Pnma (Z=4) with the parameters a=789.7(1), b=961.2(1), c=836.3(1) pm, V=0.6348(1) nm{sup 3}, R{sub 1}=0.0359 and wR{sub 2}=0.0440 (all data). The new structure type of HP-CsB{sub 5}O{sub 8} exhibits the simultaneous linkage of trigonal BO{sub 3} groups, corner-sharing BO{sub 4} tetrahedra, and edge-sharing BO{sub 4} tetrahedra including the presence of threefold-coordinated oxygen atoms. With respect to the rich structural chemistry of borates, HP-CsB{sub 5}O{sub 8} is the second structure type possessing this outstanding combination of the main structural units of borates in one compound. The structure consists of corrugated chains of corner- and edge-sharing BO{sub 4} tetrahedra interconnected through BO{sub 3} groups forming octagonal channels. Inside these channels, cesium is 13+3-fold coordinated by oxygen atoms. {sup 11}B MQMAS NMR spectra are analyzed to estimate the isotropic chemical shift values and quadrupolar parameters. IR and Raman spectra are obtained and compared to the calculated vibrational frequencies at the Γ-point. The high-temperature behavior is examined by means of temperature-programmed powder diffraction. (copyright 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  14. Metamorphic P-T path and zircon U-Pb dating of HP mafic granulites in the Yushugou granulite-peridotite complex, Chinese South Tianshan, NW China

    Science.gov (United States)

    Zhang, Lu; Zhang, Lifei; Xia, Bin; Lü, Zeng

    2018-03-01

    Co-existing granulite and peridotite may represent relics of the paleo-suture zone and provides an optimal opportunity for better understanding of orogeny between two blocks. In this study, we carried out petrological and U-Pb zircon dating investigation on the HP mafic granulites associated with peridotite complex at Yushugou in Chinese South Tianshan. The studied samples include garnet-bearing high-pressure mafic granulites which can be subdivided into two types: Type I orthopyroxene-free and Type II orthopyroxene-bearing granulites and amphibolite. Type I granulite (Y21-2) has a mineral assemblage of garnet (33 vol.%), clinopyroxene (32 vol.%) and plagioclase (30 vol.%); and Type II granulite (Y18-8) has a mineral assemblage of garnet (22 vol.%), clinopyroxene (10 vol.%), orthopyroxene (14 vol.%), plagioclase (45 vol.%) and quartz. Garnet in both granulites exhibits core-rim structure characterized by increasing grossular and decreasing pyrope from core to rim. Petrographic observations and phase equilibrium modeling using THERMOCALC in the NCFMASHTO system for the mafic granulites (Y21-2 and Y18-8) show three stages of metamorphism: Stage I (granulite facies) was recognized by the large porphyroblastic garnet core, with P-T conditions of 9.8-10.4 Kbar and 860-900 °C (Y21-2) and 9.9-10.6 Kbar and 875-890 °C (Y18-8), respectively; Stage II (HP granulite facies) has peak P-T conditions of 12.1 Kbar at 755 °C (Y21-2) and 13.8 Kbar at 815 °C (Y18-8) using mineral assemblages combining with garnet rim compositions with maximum grossular and minimum pyrope contents; Stage III (amphibolite facies) was characterized by the development of calcic amphibole in granulites with temperature of 446-563 °C. Therefore, an anticlockwise P-T path characterized by simultaneous temperature-decreasing and pressure-increasing was inferred for the Yushugou HP mafic granulite. Studies of zircon morphology and inclusions, combined with zircon U-Pb dating and REE geochemistry

  15. Determination of the dose equivalent Hp(0.07) in hands of occupationally exposed personnel in the practice of proton emission tomography (PET/CT)

    International Nuclear Information System (INIS)

    Lea, D.; Ruiz, N.; Esteves, L.

    2006-01-01

    In Venezuela recently it was implanted the Positron Emission Tomography technique (PET) with the perspective of implanting it at national level. Even when in our country practices it of nuclear medicine it exists from early of 70, there is not experience in the determination of the occupational doses by exposure to the external radiation in hands. By this reason, a concern exists in the workers of the centers of nuclear medicine where it is practiced the Positron Emission Tomography technique. In absence of the TLD dosimetry to measure dose in hands in our country, measurements of the dose equivalent of the workers of the PET national reference center were made, using a detector of hands type diode. It was determined the dose in hands in terms of dose equivalent Hp(0.07) in two work positions, that is: the corresponding to the transfer of the receiving vial of ( 18 F) FDG to the shield, quality control and uni doses division. The second work position corresponds the person in charge of administering, via intravenous, the ( 18 F) FDG. In this work it realizes the dose equivalent in hands Hp(0.07) measures in each one of the work positions before described by daily production. The informed doses correspond to a total average produced activity of 20.4 GBq (550 mCi). The results of the measurements in terms of dose equivalent in hands Hp(0.07) correspond to 2.1 ± 20% mSv in the work position of division and 0.4 ± 10% mSv in the position of injection of the radioactive material. At short term this foreseen until 4 productions per week, what means an annual dose equivalent Hp(0.07) in hands of 400 mSv approximately, without taking into account abnormal situations as its are spills of the ( 18 F) FDG in the work place. This work is the starting point so that the regulatory authority settles down, in Venezuela, dose restrictions in the PET practices and implant, in the centers of nuclear medicine, an optimization politics of this practice in conformity with the ALARA

  16. Monte Carlo determination of the conversion coefficients Hp(3)/Ka in a right cylinder phantom with 'PENELOPE' code. Comparison with 'MCNP' simulations.

    Science.gov (United States)

    Daures, J; Gouriou, J; Bordy, J M

    2011-03-01

    This work has been performed within the frame of the European Union ORAMED project (Optimisation of RAdiation protection for MEDical staff). The main goal of the project is to improve standards of protection for medical staff for procedures resulting in potentially high exposures and to develop methodologies for better assessing and for reducing, exposures to medical staff. The Work Package WP2 is involved in the development of practical eye-lens dosimetry in interventional radiology. This study is complementary of the part of the ENEA report concerning the calculations with the MCNP-4C code of the conversion factors related to the operational quantity H(p)(3). In this study, a set of energy- and angular-dependent conversion coefficients (H(p)(3)/K(a)), in the newly proposed square cylindrical phantom made of ICRU tissue, have been calculated with the Monte-Carlo code PENELOPE and MCNP5. The H(p)(3) values have been determined in terms of absorbed dose, according to the definition of this quantity, and also with the kerma approximation as formerly reported in ICRU reports. At a low-photon energy (up to 1 MeV), the two results obtained with the two methods are consistent. Nevertheless, large differences are showed at a higher energy. This is mainly due to the lack of electronic equilibrium, especially for small angle incidences. The values of the conversion coefficients obtained with the MCNP-4C code published by ENEA quite agree with the kerma approximation calculations obtained with PENELOPE. We also performed the same calculations with the code MCNP5 with two types of tallies: F6 for kerma approximation and *F8 for estimating the absorbed dose that is, as known, due to secondary electrons. PENELOPE and MCNP5 results agree for the kerma approximation and for the absorbed dose calculation of H(p)(3) and prove that, for photon energies larger than 1 MeV, the transport of the secondary electrons has to be taken into account.

  17. Preparation and comparitive analysis of MCNP thermal libraries for liquid hydrogen and deuterium using NJOY97 on 32 bit and 64 bit computers

    International Nuclear Information System (INIS)

    Jo, Y. S.; Kim, J. D.; Kil, C. S.; Jang, J. H.

    1999-01-01

    The scattering laws and MCNP thermal libraries for liquid hydrogen and deuterium are comparatively calculated on HP715 (32-bit computer) and SGI IP27 (64-bit computer) using NJOY97. The results are also compared with the experimental data. In addition, MCNP calculations for the nuclear design of a cold neutron source at HANARO are performed with the newly generated MCNP thermal libraries from two different computers and the results are compared

  18. Corifollitropin alfa compared to daily rFSH or HP-HMG in GnRH antagonist controlled ovarian stimulation protocol for patients undergoing assisted reproduction.

    Science.gov (United States)

    Souza, Priscila Morais Galvão; Carvalho, Bruno Ramalho de; Nakagawa, Hitomi Miura; Rassi, Thalita Reis Esselin; Barbosa, Antônio César Paes; Silva, Adelino Amaral

    2017-06-01

    This study aimed to compare the outcomes of controlled ovarian stimulation (COS) with corifollitropin alfa versus daily recombinant follicle-stimulating hormone (rRFSH) or highly purified human menopausal gonadotropin (HP-HMG) in patients undergoing in vitro fertilization (IVF) cycles based on gonadotropin-releasing hormone (GnRH) antagonist protocols. The primary endpoints were total number of oocytes and mature oocytes. This retrospective study looked into 132 controlled ovarian stimulation cycles from IVF or oocyte cryopreservation performed in a private human reproduction center between January 1 and December 31, 2014. Enrollment criteria: women aged 0.05). There were no significant differences in fertilization (76.9% vs. 76.8%, p=1.0), biochemical pregnancy (66.7% vs. 47.2%, p=0.1561) or embryo implantation rates (68.7% vs. 50%, p=0.2588) between the groups using corifollitropin alfa and rFSH or HMG, respectively. Corifollitropin alfa seems to be as effective as rFSH or HP-HMG when used in the first seven days of ovulation induction for patients undergoing assisted reproduction in GnRH antagonist protocols.

  19. The High Performance Shape Memory Effect (HP-SME in Ni Rich NiTi Wires: In Situ X-Ray Diffraction on Thermal Cycling

    Directory of Open Access Journals (Sweden)

    Coduri Mauro

    2015-01-01

    Full Text Available A novel approach for using Shape Memory Alloys (SMA was recently proposed and named highperformance shape memory effect (HP-SME. The HP-SME exploits the thermal cycling of stress-induced martensite for producing extremely high mechanical work with a very stable functional fatigue behaviour in Ni rich NiTi alloy. The latter was found to differ significantly from the functional fatigue behaviour observed for conventional SMA. This study was undertaken in order to elucidate the microstructural modifications at the basis of this particular feature. To this purpose, the functional fatigue was coupled to in situ Synchrotron Radiation X-Ray Diffraction, by recording patterns on wires thermally cycled by Joule effect under a constant applied stress (800 MPa. The accurate analysis the line profile XRD data suggests the accumulation of defects upon functional cycling, while the fibre texture was not observed to change. The functional fatigue exhibits a very similar behaviour as the line broadening of XRD peaks, thus suggesting the accumulation of dislocations as the origin of the mechanism of the permanent deformation.

  20. Growth promotion in pigs by oxytetracycline coincides with down regulation of serum inflammatory parameters and of hibernation-associated protein HP-27.

    Science.gov (United States)

    Soler, Laura; Miller, Ingrid; Hummel, Karin; Razzazi-Fazeli, Ebrahim; Jessen, Flemming; Escribano, Damian; Niewold, Theo

    2016-05-01

    The growth promoting effect of supplementing animal feed with antibiotics like tetracycline has traditionally been attributed to their antibiotic character. However, more evidence has been accumulated on their direct anti-inflammatory effect during the last two decades. Here we used a pig model to explore the systemic molecular effect of feed supplementation with sub therapeutic levels of oxytetracycline (OTC) by analysis of serum proteome changes. Results showed that OTC promoted growth, coinciding with a significant down regulation of different serum proteins related to inflammation, oxidation and lipid metabolism, confirming the anti-inflammatory mechanism of OTC. Interestingly, apart from the classic acute phase reactants also down regulation was seen of a hibernation associated plasma protein (HP-27), which is to our knowledge the first description in pigs. Although the exact function in non-hibernators is unclear, down regulation of HP-27 could be consistent with increased appetite, which is possibly linked to the anti-inflammatory action of OTC. Given that pigs are good models for human medicine due to their genetic and physiologic resemblance, the present results might also be used for rational intervention in human diseases in which inflammation plays an important role such as obesity, type 2 diabetes and cardiovascular diseases. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Epigenetic regulation of facultative heterochromatinisation in Planococcus citri via the Me(3)K9H3-HP1-Me(3)K20H4 pathway.

    Science.gov (United States)

    Bongiorni, Silvia; Pasqualini, Barbara; Taranta, Monia; Singh, Prim B; Prantera, Giorgio

    2007-03-15

    Using RNA interference (RNAi) we have conducted a functional analysis of the HP1-like chromobox gene pchet2 during embryogenesis of the mealybug Planococcus citri. Knocking down pchet2 expression results in decondensation of the male-specific chromocenter that normally arises from the developmentally-regulated facultative heterochromatinisation of the paternal chromosome complement. Together with the disappearance of the chromocenter the staining levels of two associated histone modifications, tri-methylated lysine 9 of histone H3 [Me(3)K9H3] and tri-methylated lysine 20 of histone H4 [Me(3)K20H4], are reduced to undetectable levels. Embryos treated with double-stranded RNA (dsRNA) targeting pchet2 also exhibit chromosome abnormalities, such as aberrant chromosome condensation, and also the presence of metaphases that contain 'lagging' chromosomes. We conclude that PCHET2 regulates chromosome behavior during metaphase and is a crucial component of a Me(3)K9H3-HP1-Me(3)K20H4 pathway involved in the facultative heterochromatinisation of the (imprinted) paternal chromosome set.

  2. Lactobacillus fermentum HP3–Mediated Fermented Hericium erinaceus Juice as a Health Promoting Food Supplement to Manage Diabetes Mellitus

    Science.gov (United States)

    Chaiyasut, Chaiyavat; Woraharn, Sasimar; Sivamaruthi, Bhagavathi Sundaram; Lailerd, Narissara; Kesika, Periyanaina; Peerajan, Sartjin

    2018-01-01

    The current study investigated the antidiabetic property of Lactobacillus fermentum HP3–mediated fermented Hericium erinaceus juice (FHJ) using male Wistar rats with streptozotocin-induced diabetes mellitus (DM). FHJ was prepared using boiled mushroom juice and L. fermentum HP3. Amino acid and γ-aminobutyric acid (GABA) content of FHJ was analyzed. Streptozotocin-induced DM rats were supplemented with FHJ in a pre- and posttreatment method. The changes in plasma insulin, plasma glucose level, glycated hemoglobin (HbA1c), representative cytokines, and the antioxidant system were assessed in experimental rats using spectrophotometric methods and enzyme-linked immunosorbent assay. The supplementation of FHJ improved the body mass, insulin level, and recovery progress of hyperglycemia. HbA1c level was altered by the FHJ intervention. The inflammatory cytokines level was suppressed in FHJ supplemented group compared with control. Intervention of FHJ and insulin improved the production of interleukin-10 and transforming growth factor-–β1 in DM rat. The study suggested that fermented H erinaceus juice may be used as one of the food-based health-promoting supplement to manage DM along with medication. PMID:29619846

  3. Optical Computing

    OpenAIRE

    Woods, Damien; Naughton, Thomas J.

    2008-01-01

    We consider optical computers that encode data using images and compute by transforming such images. We give an overview of a number of such optical computing architectures, including descriptions of the type of hardware commonly used in optical computing, as well as some of the computational efficiencies of optical devices. We go on to discuss optical computing from the point of view of computational complexity theory, with the aim of putting some old, and some very recent, re...

  4. Computational mechanics of nonlinear response of shells

    Energy Technology Data Exchange (ETDEWEB)

    Kraetzig, W.B. (Bochum Univ. (Germany, F.R.). Inst. fuer Statik und Dynamik); Onate, E. (Universidad Politecnica de Cataluna, Barcelona (Spain). Escuela Tecnica Superior de Ingenieros de Caminos) (eds.)

    1990-01-01

    Shell structures and their components are utilized in a wide spectrum of engineering fields reaching from space and aircraft structures, pipes and pressure vessels over liquid storage tanks, off-shore installations, cooling towers and domes, to bodyworks of motor vehicles. Of continuously increasing importance is their nonlinear behavior, in which large deformations and large rotations are involved as well as nonlinear material properties. The book starts with a survey about nonlinear shell theories from the rigorous point of view of continuum mechanics, this starting point being unavoidable for modern computational concepts. There follows a series of papers on nonlinear, especially unstable shell responses, which draw computational connections to well established tools in the field of static and dynamic stability of systems. Several papers are then concerned with new finite element derivations for nonlinear shell problems, and finally a series of authors contribute to specific applications opening a small window of the above mentioned wide spectrum. (orig./HP) With 159 figs.

  5. Computational mechanics of nonlinear response of shells

    International Nuclear Information System (INIS)

    Kraetzig, W.B.; Onate, E.

    1990-01-01

    Shell structures and their components are utilized in a wide spectrum of engineering fields reaching from space and aircraft structures, pipes and pressure vessels over liquid storage tanks, off-shore installations, cooling towers and domes, to bodyworks of motor vehicles. Of continuously increasing importance is their nonlinear behavior, in which large deformations and large rotations are involved as well as nonlinear material properties. The book starts with a survey about nonlinear shell theories from the rigorous point of view of continuum mechanics, this starting point being unavoidable for modern computational concepts. There follows a series of papers on nonlinear, especially unstable shell responses, which draw computational connections to well established tools in the field of static and dynamic stability of systems. Several papers are then concerned with new finite element derivations for nonlinear shell problems, and finally a series of authors contribute to specific applications opening a small window of the above mentioned wide spectrum. (orig./HP) With 159 figs

  6. Computer group

    International Nuclear Information System (INIS)

    Bauer, H.; Black, I.; Heusler, A.; Hoeptner, G.; Krafft, F.; Lang, R.; Moellenkamp, R.; Mueller, W.; Mueller, W.F.; Schati, C.; Schmidt, A.; Schwind, D.; Weber, G.

    1983-01-01

    The computer groups has been reorganized to take charge for the general purpose computers DEC10 and VAX and the computer network (Dataswitch, DECnet, IBM - connections to GSI and IPP, preparation for Datex-P). (orig.)

  7. Computer Engineers.

    Science.gov (United States)

    Moncarz, Roger

    2000-01-01

    Looks at computer engineers and describes their job, employment outlook, earnings, and training and qualifications. Provides a list of resources related to computer engineering careers and the computer industry. (JOW)

  8. Computer programs for data reduction and interpretation in plutonium and uranium analysis by gamma ray spectrometry

    International Nuclear Information System (INIS)

    Singh, R.K.; Moorthy, A.D.; Babbar, R.K.; Udagatti, S.V.

    1989-01-01

    Non destructive gamma ray have been developed for analysis of isotopic abundances and concentrations of plutonium and uranium in the respective product solutions of a reprocessing plant. The method involves analysis of gamma rays emitted from the sample and uses a multichannel analyser system. Data reduction and interpretation of these techniques are tedious and time consuming. In order to make it possible to use them in routine analysis, computer programs have been developed in HP-BASIC language which can be used in HP-9845B desktop computer. A set of programs, for plutonium estimation by high resolution gamma ray spectrometry and for on-line measurement of uranium by gamma ray spectrometry are described in this report. (author) 4 refs., 3 tabs., 6 figs

  9. Computer Music

    Science.gov (United States)

    Cook, Perry R.

    This chapter covers algorithms, technologies, computer languages, and systems for computer music. Computer music involves the application of computers and other digital/electronic technologies to music composition, performance, theory, history, and the study of perception. The field combines digital signal processing, computational algorithms, computer languages, hardware and software systems, acoustics, psychoacoustics (low-level perception of sounds from the raw acoustic signal), and music cognition (higher-level perception of musical style, form, emotion, etc.).

  10. Kanfenggou UHP Metamorphic Fragment in Eastern Qinling Orogen and Its Relationship to Dabie-Sulu UHP and HP Metamorphic Belts, Central China

    Institute of Scientific and Technical Information of China (English)

    Suo Shutian; Zhong Zengqiu; Zhou Hanwen; You Zhendong

    2003-01-01

    In the Central Orogenic Belt, China, two UHP metamorphic belts are discriminated mainly based on a detailed structural analysis of the Kanfenggou UHP metamorphic fragment exposed in the eastern Qinling orogen, and together with previous regional structural, petrological and geochronological data at the scale of the orogenic domain. The first one corresponds to the South Altun-North QaidamNorth Qinling UHP metamorphic belt. The other is the Dabie-Sulu UHP and HP metamorphic belts. The two UHP metamorphic belts are separated by a series of tectonic slices composed by the Qinling rock group, Danfeng rock group and Liuling or Foziling rock group etc. respectively, and are different in age of the peak UHP metamorphism and geodynamic implications for continental deep subduction and collision. Regional field and petrological relationships suggest that the Kanfenggou UHP metamorphic fragment that contains a large volume of the coesite- and microdiamond-bearing eclogite lenses is compatible with the structures recognized in the South Altun and North Qaidam UHP metamorphic fragments exposed in the western part of China, thereby forming a large UHP metamorphic belt up to 1 000 km long along the orogen strike. This UHP metamorphic belt represents an intercontinental deep subduction and collision belt between the Yangtze and Sino-Korean cratons, occurred during the Paleozoic. On the other hand, the well-constrained Dabie-Sulu UHP and HP metamorphic belts occurred mainly during Triassic time (250-220 Ma), and were produced by the intrucontinental deep subduction and collision within the Yangtze craton. The Kanfenggou UHP metamorphic fragment does not appear to link with the Dabie-Sulu UHP and HP metamorphic belts along the orogen. There is no reason to assume the two UHP metamorphic belts us a single giant deep subduction and collision zone in the Central Orogenic Belt situated between the Yangtze and Sino-Korean cratons. Therefore, any dynamic model for the orogen must account

  11. Emergence of highly pathogenic porcine reproductive and respiratory syndrome (HP-PRRS) in medium-scale swine farms in southeastern Cambodia.

    Science.gov (United States)

    Tornimbene, B; Frossard, J-P; Chhim, V; Sorn, S; Guitian, J; Drew, T W

    2015-01-01

    Since 2006, reports from China and Viet Nam have alerted of an emergent highly pathogenic variant of porcine reproductive and respiratory syndrome virus (HP-PRRSV) in that region. The frequent occurrence of outbreaks in these countries puts Cambodian pig farms at high risk of infection, but no study had been conducted to investigate the presence of HP-PRRS in Cambodian farms. We investigated the presence of HP-PRRS in medium-scale (semi-commercial) swine farms in the Cambodian southeastern region. Specifically, one province bordering Viet Nam (Takeo) was selected due to the concentration of most semi-commercial farms in that province. A cross-sectional study was carried out, between July and September 2010 to assess whether the prevalence of infection in these farms was indicative of recent spread of PPRSV and to identify risk factors for infection. The number of farms to be sampled was established using methods for Lot Quality Assurance Surveys (LQAS), in order to achieve a pre-established ability to discriminate between two different prevalence settings. The target population comprised all semi-commercial farms in Takeo province from which a random sample of 35 farms was selected. Selected farms were visited and questionnaires administered to gather information on farm characteristics and husbandry practices. Blood samples from individual pigs were collected in each of the study farms and tested for PRRSV, along with a number of other swine respiratory pathogens in order to investigate potential interactions. Our results showed that the virus was already present in Takeo semi-commercial pig population (LQAS herd prevalence ≥85%) at the time of sampling. The presence of sows in the farm and farm density were significantly associated (P<0.05) with the introduction and the presence of PRRS - but this was an unadjusted association as small sample size precluded multivariate analysis. Spatiotemporal description of the supposed pattern of infection revealed that the

  12. Virus-cell fusion inhibitory activity of novel analogue peptides based on the HP (2-20) derived from N-terminus of Helicobacter pylori Ribosomal Protein L1.

    Science.gov (United States)

    Woo, Eun-Rhan; Lee, Dong Gun; Chang, Young-Su; Park, Yoonkyung; Hahm, Kyung-Soo

    2002-12-01

    HP (2-20) (AKKVFKRLEKLFSKIQNDK) is the antibacterial sequence derived from N-terminus of Helicobacter pylori Ribosomal Protein L1 (RPL1). It has a broad-spectrum microbicidal activity in vitro that is thought to be related to the membrane-disruptive properties of the peptide. Based on the putative membrane-targeted mode of action, we postulated that HP (2-20) might be possessed virus-cell fusion inhibitory activity. To develop the novel virus-cell fusion inhibitory peptides, several analogues with amino acid substitution were designed to increase or decrease only net hydrophobic region. In particular, substitution of Gln and Asp for hydrophobic amino acid, Trp at position 17 and 19 of HP (2-20) (Anal 3) caused a dramatic increase in virus-cell fusion inhibitory activity without hemolytic effect.

  13. Addendum report of the JHPS expert committee on radiation protection of the lens of the eye (2). When and how should the dosimetry of beta H_p(3) be made?

    International Nuclear Information System (INIS)

    Akahane, Keiichi; Tatsuzaki, Hideo; Iimoto, Takeshi; Ichiji, Takeshi; Hamada, Nobuyuki; Iwai, Satoshi; Ohguchi, Hiroyuki; Ohno, Kazuko; Kawaura, Chiyo; Kurosawa, Tadahiro; Tsujimura, Norio; Hayashida, Toshiyuki; Hotta, Yutaka; Yamasaki, Tadashi; Yokoyama, Sumi

    2015-01-01

    In a mixed field of photon and beta radiations, the same dose assigned to skin is normally assigned to the dose to the lens of the eye as a conservative estimate of H_p(3). In exceptional cases where a very high beta dose might be imparted of the same order with the dose limit, however, the conservatively biased dose must be too limiting, and thereby an accurate estimate of beta H_p(3) is desirable. This addendum report of the Japan Health Physics Society Expert Committee on Radiation Protection of the Lens of the Eye presents a practical proposal of when and how the dosimetry of beta H_p(3) should be made. (author)

  14. Asymmetry in the momentum distribution of H+p from dissociative ionization of H2 controlled by the carrier-envelope phase of a few-cycle pulse

    Science.gov (United States)

    Zeng, Shuo; Anis, Fatima; Esry, B. D.

    2010-03-01

    We present theoretical results on the interaction of H2 with an ultrashort linearly polarized laser pulse of 6 fs duration. We investigate the carrier-envelope phase effects of this ultrashort laser pulse on the asymmetry of the momentum distribution of H+p along the laser polarization direction. To do so, we model the H2 ionization by launching a coherent wavepacket on H2^+ potential curves at each field maximum, and then propagate wavepackets in time on H2^+ Born-Oppenheimer potential curves coupled by the laser. Nuclear rotation and vibration are both included in the Schrödinger equation for H2^+ . Our results will be compared to a recent experimental measurement [1]. We will also compare our results to calculations neglecting rotation and discuss the limitations of such a model.[4pt] [1] Manuel Kremer et al., Phys. Rev. Lett. 103.213003 (2009)

  15. Texture and structure contribution to low-temperature plasticity enhancement of Mg-Al-Zn-Mn Alloy MA2-1hp after ECAP and annealing

    Science.gov (United States)

    Serebryany, V. N.; D'yakonov, G. S.; Kopylov, V. I.; Salishchev, G. A.; Dobatkin, S. V.

    2013-05-01

    Equal channel angular pressing (ECAP) in magnesium alloys due to severe plastic shear deformations provides both grain refinement and the slope of the initial basal texture at 40°-50° to the pressing direction. These changes in microstructure and texture contribute to the improvement of low-temperature plasticity of the alloys. Quantitative texture X-ray diffraction analysis and diffraction of backscattered electrons are used to study the main textural and structural factors responsible for enhanced low-temperature plasticity based on the example of magnesium alloy MA2-1hp of the Mg-Al-Zn-Mn system. The possible mechanisms of deformation that lead to this positive effect are discussed.

  16. Performance Evaluation of a HP/ORC (Heat Pump/Organic Rankine Cycle) System with Optimal Control of Sensible Thermal Storage

    DEFF Research Database (Denmark)

    Carmo, Carolina; Nielsen, Mads P.; Elmegaard, Brian

    2016-01-01

    In energy systems with high share of renewable energy sources, like wind and solar power, it is paramount to deal with their intrinsic variability. The interaction between electric and thermal energy (heating and cooling) demands representa potential area for balancing supply and demand that could...... come to contribute to the integration of intermittent renewables.This paper describes an innovative concept that consists of the addition of an Organic Rankine Cycle (ORC) toa combined solar system coupled to a ground-source heat pump (HP) in a single-family building. The ORC enables the use of solar...... energy in periods of no thermal energy demand and reverses the heat pump cycle to supply electricalpower. A dynamic model based on empirical data of this system is used to determine the annual performance. Furthermore, this work assesses the benefits of different control strategies that address...

  17. Use of mucolytic agents and guaran HEPART (HP-7000) for the detection of mucosal villi in double contrast barium studies of the small intestine

    International Nuclear Information System (INIS)

    Desaga, J.F.

    1987-01-01

    It was the aim of this study to enhance the visualisation of mucosal villi by double contrast barium studies of the small bowel. Prior to the radiological examination a 2-day pretreatment with the mucolytic agents acetylcysteine or carbocisteine was effected. Double contrast studies were performed with a high-molecular fraction of guaran HEPART (HP-7000), a hydrocolloidal isolated from the seed endosperm of C. tetragonolobus added into contrast-medium and distention medium. Compared to double contrast studies without mucolytic therapy, this procedure results in a better transparency and demonstration of the mucosal villi shown by a granular pattern in the radiographs. High quality visualisation of intestinal villi was achieved in all patients studied. A 2-day pretreatment with carbocisteine or acetylcysteine and the use of guaran in the double contrast barium study of the small bowel results in a greatly enhanced visualisation of mucosal villi. (orig.) [de

  18. IMPACT OF DEPTH OF CUT ON CHIP FORMATION IN AZ91HP MAGNESIUM ALLOY MILLING WITH TOOLS OF VARYING CUTTING EDGE GEOMETRY

    Directory of Open Access Journals (Sweden)

    Olga Gziut

    2015-05-01

    Full Text Available Safety of Mg milling processes can be expressed by means of the form and the number of fractions of chips formed during milling. This paper presents the state of the art of magnesium alloys milling technology in the aspect of chip fragmentation. Furthermore, the impact of the depth of cut ap and the rake angle γ on the number of chip fractions was analysed in the study. These were conducted on AZ91HP magnesium cast alloy and milling was performed with carbide tools of varying rake angle values (γ = 5º and γ = 30º. It was observed that less intense chip fragmentation occurs with decreasing depth of cut ap. The number of chip fractions was lower at the tool rake angle of γ = 30º. The test results were formulated as technological recommendations according to the number of generated chip fractions.

  19. Engineering description of the OMS/RCS/DAP modes used in the HP-9825A High Fidelity Relative Motion Program (HFRMP)

    Science.gov (United States)

    Wilson, S. W.

    1978-01-01

    Simplified mathematical models are reported for the space shuttle's Orbital Maneuvering System (OMS), Reaction Control System (RCS), and on-orbit Digital Autopilot (DAP) that have been incorporated in the High-Fidelity Relative Motion Program (HFRMP) for the HP-9825A desk-top calculator. Comparisons were made between data generated by the HFRMP and by the Space Shuttle Functional Simulator (SSFS), which models the cited shuttle systems in much greater detail. These data include propellant requirements for representative translational maneuvers, rotational maneuvers, and attitude maintenance options. Also included are data relating to on-orbit trajectory deviations induced by RCS translational cross coupling. Potential close-range stationkeeping problems that are suggested by HFRMP simulations of 80 millisecond (as opposed to 40 millisecond) DAP cycle effects are described. The principal function of the HFRMP is to serve as a flight design tool in the area of proximity operations.

  20. Use of a low-background and anti-Compton HpGe gamma-spectrometer in analyses of environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Qiong, Su; Yamin, Gao [Ministry of Public Health, Beijing, BJ (China). Lab. of Industrial Hygiene

    1989-12-01

    The results of application of a HpGe gamma-spectrometer in the analyses of enviromental samples are reported. The spectrometer has very low background and good property of Compton suppression. By comparison between the gamma-spectra with and without anti-coincidence shield for the same samples, the advantage in analysing environmental samples became apparent. In the analyses of carp samples, the ratio of specific activities of {sup 226}Ra in the flesh and bone of the carp was 1 to 35, which is basically in agreement with the ratio of the accumulation factors 1:37, as reported in the literature. Thus the spectrometer would play an important role in the research of the transfer of radionuclides of low activity in the environment. The method of gamma-ray data processing is also described.

  1. Use of a low-background and anti-Compton HpGe gamma-spectrometer in analyses of environmental samples

    International Nuclear Information System (INIS)

    Su Qiong; Gao Yamin

    1989-01-01

    The results of application of a HpGe gamma-spectrometer in the analyses of enviromental samples are reported. The spectrometer has very low background and good property of Compton suppression. By comparison between the gamma-spectra with and without anti-coincidence shield for the same samples, the advantage in analysing environmental samples became apparent. In the analyses of carp samples, the ratio of specific activities of 226 Ra in the flesh and bone of the carp was 1 to 35, which is basically in agreement with the ratio of the accumulation factors 1:37, as reported in the literature. Thus the spectrometer would play an important role in the research of the transfer of radionuclides of low activity in the environment. The method of gamma-ray data processing is also described

  2. Using a progress computer for the direct acquisition and processing of radiation protection data

    International Nuclear Information System (INIS)

    Barz, H.G.; Borchardt, K.D.; Hacke, J.; Kirschfeld, K.E.; Kluppak, B.

    1976-01-01

    A process computer will be used in the Hahn-Meitner-Institute to rationalize radiation protection measures. Appr. 150 transmitters are to be connected with this computer. Especially the radiation measuring devices of a nuclear reactor, of hot cells, and of a heavy ion accelerator, as well as the emission- and environment monitoring systems will be connected. The advantages of this method are described: central data acquisition, central alarm and stoppage information, data processing of certain measurement values, possibility of quick disturbance analysis. Furthermore the authors report about the preparations already finished, particularly about data transmission of digital and analog values to the computer. (orig./HP) [de

  3. The Combination Process for Preparative Separation and Purification of Paclitaxel and 10-Deacetylbaccatin III Using Diaion® Hp-20 Followed by Hydrophilic Interaction Based Solid Phase Extraction

    Science.gov (United States)

    Shirshekanb, Mahsa; Rezadoost, Hassan; Javanbakht, Mehran; Ghassempour, Ali Reza

    2017-01-01

    There is no other naturally occurring defense agent against cancer that has a stronger effect than paclitaxel, commonly known under the brand name of Taxol®. The major drawback for the more widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DAB III), is that they require large-scale extraction from different parts of yew trees (Taxus species), cell cultures, taxane-producing endophytic fungi, and Corylus species. In our previous work, a novel online two-dimensional heart-cut liquid chromatography process using hydrophilic interaction/ reversed-phase chromatography was used to introduce a semi-preparative treatment for the separation of polar (10-deacetylbaccatin III) and non-polar (paclitaxel) taxanes from Taxus baccata L. In this work, a combination of the absorbent (Diaion® HP-20) and a silica based solid phase extraction is utilized as a new, efficient, and cost effective method for large-scale production of taxanes. This process avoids the technical problem of two-dimensional preparative liquid chromatography. The first stage of the process involves discarding co-extractive polar compounds including chlorophylls and pigments using a non-polar synthetic hydrophobic absorbent, Diaion® HP-20. Extract was then loaded on to a silica based hydrophilic interaction solid phase extraction (silica 40-60 micron). Taxanes was eluted using a mixture of water and methanol at the optimized ratio of 70:30. Finally, the fraction containing taxanes was applied to semi-preparative reversed phase HPLC. The results revealed that using this procedure, paclitaxel and 10-DAB III could be obtained at 8 and 3 times more, respectively than by the traditional method of extraction. PMID:29552048

  4. The Combination Process for Preparative Separation and Purification of Paclitaxel and 10-Deacetylbaccatin III Using Diaion® Hp-20 Followed by Hydrophilic Interaction Based Solid Phase Extraction.

    Science.gov (United States)

    Shirshekanb, Mahsa; Rezadoost, Hassan; Javanbakht, Mehran; Ghassempour, Ali Reza

    2017-01-01

    There is no other naturally occurring defense agent against cancer that has a stronger effect than paclitaxel, commonly known under the brand name of Taxol ® . The major drawback for the more widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DAB III), is that they require large-scale extraction from different parts of yew trees ( Taxus species), cell cultures, taxane-producing endophytic fungi, and Corylus species. In our previous work, a novel online two-dimensional heart-cut liquid chromatography process using hydrophilic interaction/ reversed-phase chromatography was used to introduce a semi-preparative treatment for the separation of polar (10-deacetylbaccatin III) and non-polar (paclitaxel) taxanes from Taxus baccata L. In this work, a combination of the absorbent (Diaion ®  HP-20) and a silica based solid phase extraction is utilized as a new, efficient, and cost effective method for large-scale production of taxanes. This process avoids the technical problem of two-dimensional preparative liquid chromatography. The first stage of the process involves discarding co-extractive polar compounds including chlorophylls and pigments using a non-polar synthetic hydrophobic absorbent, Diaion ®  HP-20. Extract was then loaded on to a silica based hydrophilic interaction solid phase extraction (silica 40-60 micron). Taxanes was eluted using a mixture of water and methanol at the optimized ratio of 70:30. Finally, the fraction containing taxanes was applied to semi-preparative reversed phase HPLC. The results revealed that using this procedure, paclitaxel and 10-DAB III could be obtained at 8 and 3 times more, respectively than by the traditional method of extraction.

  5. Analog computing

    CERN Document Server

    Ulmann, Bernd

    2013-01-01

    This book is a comprehensive introduction to analog computing. As most textbooks about this powerful computing paradigm date back to the 1960s and 1970s, it fills a void and forges a bridge from the early days of analog computing to future applications. The idea of analog computing is not new. In fact, this computing paradigm is nearly forgotten, although it offers a path to both high-speed and low-power computing, which are in even more demand now than they were back in the heyday of electronic analog computers.

  6. Computational composites

    DEFF Research Database (Denmark)

    Vallgårda, Anna K. A.; Redström, Johan

    2007-01-01

    Computational composite is introduced as a new type of composite material. Arguing that this is not just a metaphorical maneuver, we provide an analysis of computational technology as material in design, which shows how computers share important characteristics with other materials used in design...... and architecture. We argue that the notion of computational composites provides a precise understanding of the computer as material, and of how computations need to be combined with other materials to come to expression as material. Besides working as an analysis of computers from a designer’s point of view......, the notion of computational composites may also provide a link for computer science and human-computer interaction to an increasingly rapid development and use of new materials in design and architecture....

  7. Measurement of personal equivalent dose Hp(3) during procedures involving in positron emission tomography; Medida del equivalente de dosis personal en cristalino Hp(3) durante los procedimientos asociados a la tomografía por emisión de positrones

    Energy Technology Data Exchange (ETDEWEB)

    Guiu Souto, J.; Sánchez García, M.; Vázquez, R.; Pardo Montero, J.; Pombar Cameán, M.

    2017-11-01

    The aim of the present study consists to determinate the personal equivalent dose Hp(3) at eye lens during the procedures involved in positron emission tomography. We have monitored the nurse's staff which is responsible of handling and dispensing 18F. We characterize the relevant stages as the preparation, the transport and the administration of monodose syringes in terms of occupational dose. We observed that the preparation presents a major contribution to the occupational doses than the other stages. In addition, during those stage there is a correlation between the dose increments and handling activity. To establish the eye lens dose we use the following dosimetry set: a direct readout solid state dosimeter for general purposes calibrated at Hp(10) and a set of thermolumiscent dosimeters specific for 18F calibrated at Hp(3). Finally, for the dose intercomparison between above dosimeters we obtain a correction factor by Monte Carlo. The eye lens dose, with a value of 2.8 ± 0.4 mSv/yr, results more critical than the dose obtained in other locations, as extremities. [Spanish] El propósito del presente trabajo consiste en la determinación del equivalente de dosis personal Hp(3) en cristalino durante los procedimientos asociados a la tomografía por emisión de positrones. Se ha monitorizado al personal de enfermería que realiza las tareas de manipulación y dispensación del 18F. Se ha realizado un estudio caracterizando la dosis en las etapas más relevantes del procedimiento: la preparación manual de las jeringuillas, el transporte de las mismas y su posterior administración al paciente. Se observó que la preparación es la etapa que más contribuye a la dosis ocupacional, además durante dicha etapa se observa una clara correlación entre el incremento de dosis y la actividad manipulada. Para determinar la dosis en cristalino se ha utilizado el siguiente equipo dosimétrico: un detector de estado sólido de lectura directa de propósito general

  8. The tensor analyzing power T20 in the dd → 3Hen and dd → 3Hp reactions at the energies 140, 200 and 270 MeV and at zero degree

    International Nuclear Information System (INIS)

    Ladygin, V.P.; Uesaka, T.; Saito, T.

    2005-01-01

    The data on the tensor analyzing power T 20 in the dd → 3 Hen and dd → 3 Hp reactions at 140, 200 and 270 MeV of the deuteron kinetic energy and at zero degree obtained at RIKEN Accelerator Research Facility are presented. The observed positive sign of T 20 clearly demonstrates the sensitivity to the D/S wave ratios in the 3 He and 3 H in the energy domain of the measurements. The T 20 data for the 3 He-n and 3 H-p channels are in agreement within experimental accuracy

  9. Tensor analyzing power T20 of the dd →3Hen and dd →3Hp reactions at zero angle for energies 140, 200, and 270 MeV

    International Nuclear Information System (INIS)

    Ladygin, V. P.; Uesaka, T.; Saito, T.; Hatano, M.; Isupov, A. Yu.; Kato, H.; Ladygina, N. B.; Maeda, Y.; Malakhov, A. I.; Nishikawa, J.; Ohnishi, T.; Okamura, H.; Reznikov, S. G.; Sakai, H.; Sakamoto, N.; Sakoda, S.; Satou, Y.; Sekiguchi, K.; Suda, K.; Tamii, A.

    2006-01-01

    RIKEN Accelerator Research Facility data on the tensor analyzing power T 20 of the dd → 3 Hen and dd → 3 Hp reactions at zero angle for deuteron kinetic energies of 140, 200, and 270 MeV are reported. The observed positive sign of T 20 clearly demonstrates the sensitivity to the D/S-wave ratio in the 3 He and 3 H wave functions in the energy range of the experiment. Data on T 20 for the 3 Hen channel are in agreement with those for the 3 Hp channel within the experimental errors

  10. The tensor analyzing power T20 in the dd → 3Hen and dd → 3Hp reactions at the energies 140, 200 and 270 MeV at zero angle

    International Nuclear Information System (INIS)

    Ladygin, V.P.; ); Uesaka, T.; Saito, T.

    2006-01-01

    The data on the tensor analyzing power T 20 in the dd → 3 Hen and dd → 3 Hp reactions at 140, 200 and 270 MeV of the deuteron kinetic energy and at zero angle obtained at RIKEN Accelerator Research Facility are presented. The observed positive sign of T 20 clearly demonstrates the sensitivity to the D/S wave ratios in the 3 He and 3 H in the energy domain of the measurements. The T 20 data for the 3 Hen and 3 Hp channels are in agreement within experimental accuracy [ru

  11. Quantum Computing

    OpenAIRE

    Scarani, Valerio

    1998-01-01

    The aim of this thesis was to explain what quantum computing is. The information for the thesis was gathered from books, scientific publications, and news articles. The analysis of the information revealed that quantum computing can be broken down to three areas: theories behind quantum computing explaining the structure of a quantum computer, known quantum algorithms, and the actual physical realizations of a quantum computer. The thesis reveals that moving from classical memor...

  12. Determination of the dose equivalent Hp(0.07) in hands of occupationally exposed personnel in the practice of proton emission tomography (PET/CT); Determinacion de la dosis equivalente Hp(0.07) en manos de trabajadores ocupacionalmente expuestos en la practica de Tomografia por Emision de Positrones (PET/CT)

    Energy Technology Data Exchange (ETDEWEB)

    Lea, D. [Servicio de Radiofisica Sanitaria, Unidad de Tecnologia Nuclear, Instituto Venezolano de Investigaciones Cientificas, Ministerio de Ciencia y Tecnologia, Km 11 Carretera Panamerican, Altos del Pipe, Caracas (Venezuela); Ruiz, N.; Esteves, L. [Centro Diagnostico Docente Las Mercedes, Calle Paris cruce con calle Caroni, Edif. CDD, Las Mercedes, Caracas (Venezuela)]. e-mail: dlea@ivic.ve

    2006-07-01

    In Venezuela recently it was implanted the Positron Emission Tomography technique (PET) with the perspective of implanting it at national level. Even when in our country practices it of nuclear medicine it exists from early of 70, there is not experience in the determination of the occupational doses by exposure to the external radiation in hands. By this reason, a concern exists in the workers of the centers of nuclear medicine where it is practiced the Positron Emission Tomography technique. In absence of the TLD dosimetry to measure dose in hands in our country, measurements of the dose equivalent of the workers of the PET national reference center were made, using a detector of hands type diode. It was determined the dose in hands in terms of dose equivalent Hp(0.07) in two work positions, that is: the corresponding to the transfer of the receiving vial of ({sup 18}F) FDG to the shield, quality control and uni doses division. The second work position corresponds the person in charge of administering, via intravenous, the ({sup 18}F) FDG. In this work it realizes the dose equivalent in hands Hp(0.07) measures in each one of the work positions before described by daily production. The informed doses correspond to a total average produced activity of 20.4 GBq (550 mCi). The results of the measurements in terms of dose equivalent in hands Hp(0.07) correspond to 2.1 {+-} 20% mSv in the work position of division and 0.4 {+-} 10% mSv in the position of injection of the radioactive material. At short term this foreseen until 4 productions per week, what means an annual dose equivalent Hp(0.07) in hands of 400 mSv approximately, without taking into account abnormal situations as its are spills of the ({sup 18}F) FDG in the work place. This work is the starting point so that the regulatory authority settles down, in Venezuela, dose restrictions in the PET practices and implant, in the centers of nuclear medicine, an optimization politics of this practice in conformity

  13. Analysis of a HP-refinement method for solving the neutron transport equation using two error estimators

    International Nuclear Information System (INIS)

    Fournier, D.; Le Tellier, R.; Suteau, C.; Herbin, R.

    2011-01-01

    The solution of the time-independent neutron transport equation in a deterministic way invariably consists in the successive discretization of the three variables: energy, angle and space. In the SNATCH solver used in this study, the energy and the angle are respectively discretized with a multigroup approach and the discrete ordinate method. A set of spatial coupled transport equations is obtained and solved using the Discontinuous Galerkin Finite Element Method (DGFEM). Within this method, the spatial domain is decomposed into elements and the solution is approximated by a hierarchical polynomial basis in each one. This approach is time and memory consuming when the mesh becomes fine or the basis order high. To improve the computational time and the memory footprint, adaptive algorithms are proposed. These algorithms are based on an error estimation in each cell. If the error is important in a given region, the mesh has to be refined (h−refinement) or the polynomial basis order increased (p−refinement). This paper is related to the choice between the two types of refinement. Two ways to estimate the error are compared on different benchmarks. Analyzing the differences, a hp−refinement method is proposed and tested. (author)

  14. Safety analysis of control rod drive computers

    International Nuclear Information System (INIS)

    Ehrenberger, W.; Rauch, G.; Schmeil, U.; Maertz, J.; Mainka, E.U.; Nordland, O.; Gloee, G.

    1985-01-01

    The analysis of the most significant user programmes revealed no errors in these programmes. The evaluation of approximately 82 cumulated years of operation demonstrated that the operating system of the control rod positioning processor has a reliability that is sufficiently good for the tasks this computer has to fulfil. Computers can be used for safety relevant tasks. The experience gained with the control rod positioning processor confirms that computers are not less reliable than conventional instrumentation and control system for comparable tasks. The examination and evaluation of computers for safety relevant tasks can be done with programme analysis or statistical evaluation of the operating experience. Programme analysis is recommended for seldom used and well structured programmes. For programmes with a long, cumulated operating time a statistical evaluation is more advisable. The effort for examination and evaluation is not greater than the corresponding effort for conventional instrumentation and control systems. This project has also revealed that, where it is technologically sensible, process controlling computers or microprocessors can be qualified for safety relevant tasks without undue effort. (orig./HP) [de

  15. Computational Medicine

    DEFF Research Database (Denmark)

    Nygaard, Jens Vinge

    2017-01-01

    The Health Technology Program at Aarhus University applies computational biology to investigate the heterogeneity of tumours......The Health Technology Program at Aarhus University applies computational biology to investigate the heterogeneity of tumours...

  16. Grid Computing

    Indian Academy of Sciences (India)

    A computing grid interconnects resources such as high performancecomputers, scientific databases, and computercontrolledscientific instruments of cooperating organizationseach of which is autonomous. It precedes and is quitedifferent from cloud computing, which provides computingresources by vendors to customers ...

  17. Green Computing

    Directory of Open Access Journals (Sweden)

    K. Shalini

    2013-01-01

    Full Text Available Green computing is all about using computers in a smarter and eco-friendly way. It is the environmentally responsible use of computers and related resources which includes the implementation of energy-efficient central processing units, servers and peripherals as well as reduced resource consumption and proper disposal of electronic waste .Computers certainly make up a large part of many people lives and traditionally are extremely damaging to the environment. Manufacturers of computer and its parts have been espousing the green cause to help protect environment from computers and electronic waste in any way.Research continues into key areas such as making the use of computers as energy-efficient as Possible, and designing algorithms and systems for efficiency-related computer technologies.

  18. Clinical efficacy and cost-effectiveness of HP-human FSH (Fostimon®) versus rFSH (Gonal-F®) in IVF-ICSI cycles: a meta-analysis.

    Science.gov (United States)

    Gerli, Sandro; Bini, Vittorio; Favilli, Alessandro; Di Renzo, Gian Carlo

    2013-06-01

    Clinical efficacy of human-derived follicle-stimulating hormone (FSH) versus recombinant FSH (rFSH) in IVF-ICSI cycles has long been compared, but no clear evidence of the superiority of a preparation over the other has been found. Human gonadotropins have been often grouped together, but a different glycosylation may be present in each preparation, therefore influencing the specific bioactivity. To exclude confounding factors, a meta-analysis and a cost-effectiveness analysis were designed to compare effectiveness and cost-effectiveness of a specific highly purified human FSH (HP-hFSH) (Fostimon®) versus rFSH (Gonal-F®) in IVF/ICSI cycles. Research methodology filters were applied in MEDLINE, Current Contents and Web of Science from 1980 to February 2012. Eight randomized trials met selection criteria. The meta-analysis showed no significant differences between rFSH and HP-hFSH treatment in live-birth rate (odds ratio [OR] 0.84, 95% confidence interval [CI] 0.63-1.11), clinical pregnancy rate (OR 0.85, 95% CI 0.68-1.07), number of oocytes retrieved, number of mature oocytes and days of stimulation. The cost-effectiveness ratio was € 7174 in the rFSH group and € 2056 in the HP-hFSH group. HP-hFSH is as effective as rFSH in ovarian stimulation for IVF-ICSI cycles, but the human preparation is more cost-effective.

  19. Metamorphic P-T-t-d evolution of (U)HP metabasites from the South Tianshan accretionary complex (NW China) - Implications for rock deformation during exhumation in a subduction channel

    Czech Academy of Sciences Publication Activity Database

    Soldner, J.; Oliot, E.; Schulmann, K.; Štípská, P.; Kusbach, Vladimír; Anczkiewicz, R.

    2017-01-01

    Roč. 47, July (2017), s. 161-187 ISSN 1342-937X Institutional support: RVO:67985530 Keywords : eclogite * Tianshan massif * (U)HP metamorphic belt Subject RIV: DB - Geology ; Mineralogy OBOR OECD: Geology Impact factor: 6.959, year: 2016

  20. Quantum computers and quantum computations

    International Nuclear Information System (INIS)

    Valiev, Kamil' A

    2005-01-01

    This review outlines the principles of operation of quantum computers and their elements. The theory of ideal computers that do not interact with the environment and are immune to quantum decohering processes is presented. Decohering processes in quantum computers are investigated. The review considers methods for correcting quantum computing errors arising from the decoherence of the state of the quantum computer, as well as possible methods for the suppression of the decohering processes. A brief enumeration of proposed quantum computer realizations concludes the review. (reviews of topical problems)

  1. Quantum Computing for Computer Architects

    CERN Document Server

    Metodi, Tzvetan

    2011-01-01

    Quantum computers can (in theory) solve certain problems far faster than a classical computer running any known classical algorithm. While existing technologies for building quantum computers are in their infancy, it is not too early to consider their scalability and reliability in the context of the design of large-scale quantum computers. To architect such systems, one must understand what it takes to design and model a balanced, fault-tolerant quantum computer architecture. The goal of this lecture is to provide architectural abstractions for the design of a quantum computer and to explore

  2. Pervasive Computing

    NARCIS (Netherlands)

    Silvis-Cividjian, N.

    This book provides a concise introduction to Pervasive Computing, otherwise known as Internet of Things (IoT) and Ubiquitous Computing (Ubicomp) which addresses the seamless integration of computing systems within everyday objects. By introducing the core topics and exploring assistive pervasive

  3. Computational vision

    CERN Document Server

    Wechsler, Harry

    1990-01-01

    The book is suitable for advanced courses in computer vision and image processing. In addition to providing an overall view of computational vision, it contains extensive material on topics that are not usually covered in computer vision texts (including parallel distributed processing and neural networks) and considers many real applications.

  4. Spatial Computation

    Science.gov (United States)

    2003-12-01

    Computation and today’s microprocessors with the approach to operating system architecture, and the controversy between microkernels and monolithic kernels...Both Spatial Computation and microkernels break away a relatively monolithic architecture into in- dividual lightweight pieces, well specialized...for their particular functionality. Spatial Computation removes global signals and control, in the same way microkernels remove the global address

  5. Computational strategies for three-dimensional flow simulations on distributed computer systems

    Science.gov (United States)

    Sankar, Lakshmi N.; Weed, Richard A.

    1995-08-01

    This research effort is directed towards an examination of issues involved in porting large computational fluid dynamics codes in use within the industry to a distributed computing environment. This effort addresses strategies for implementing the distributed computing in a device independent fashion and load balancing. A flow solver called TEAM presently in use at Lockheed Aeronautical Systems Company was acquired to start this effort. The following tasks were completed: (1) The TEAM code was ported to a number of distributed computing platforms including a cluster of HP workstations located in the School of Aerospace Engineering at Georgia Tech; a cluster of DEC Alpha Workstations in the Graphics visualization lab located at Georgia Tech; a cluster of SGI workstations located at NASA Ames Research Center; and an IBM SP-2 system located at NASA ARC. (2) A number of communication strategies were implemented. Specifically, the manager-worker strategy and the worker-worker strategy were tested. (3) A variety of load balancing strategies were investigated. Specifically, the static load balancing, task queue balancing and the Crutchfield algorithm were coded and evaluated. (4) The classical explicit Runge-Kutta scheme in the TEAM solver was replaced with an LU implicit scheme. And (5) the implicit TEAM-PVM solver was extensively validated through studies of unsteady transonic flow over an F-5 wing, undergoing combined bending and torsional motion. These investigations are documented in extensive detail in the dissertation, 'Computational Strategies for Three-Dimensional Flow Simulations on Distributed Computing Systems', enclosed as an appendix.

  6. Computational strategies for three-dimensional flow simulations on distributed computer systems

    Science.gov (United States)

    Sankar, Lakshmi N.; Weed, Richard A.

    1995-01-01

    This research effort is directed towards an examination of issues involved in porting large computational fluid dynamics codes in use within the industry to a distributed computing environment. This effort addresses strategies for implementing the distributed computing in a device independent fashion and load balancing. A flow solver called TEAM presently in use at Lockheed Aeronautical Systems Company was acquired to start this effort. The following tasks were completed: (1) The TEAM code was ported to a number of distributed computing platforms including a cluster of HP workstations located in the School of Aerospace Engineering at Georgia Tech; a cluster of DEC Alpha Workstations in the Graphics visualization lab located at Georgia Tech; a cluster of SGI workstations located at NASA Ames Research Center; and an IBM SP-2 system located at NASA ARC. (2) A number of communication strategies were implemented. Specifically, the manager-worker strategy and the worker-worker strategy were tested. (3) A variety of load balancing strategies were investigated. Specifically, the static load balancing, task queue balancing and the Crutchfield algorithm were coded and evaluated. (4) The classical explicit Runge-Kutta scheme in the TEAM solver was replaced with an LU implicit scheme. And (5) the implicit TEAM-PVM solver was extensively validated through studies of unsteady transonic flow over an F-5 wing, undergoing combined bending and torsional motion. These investigations are documented in extensive detail in the dissertation, 'Computational Strategies for Three-Dimensional Flow Simulations on Distributed Computing Systems', enclosed as an appendix.

  7. Parallel computations

    CERN Document Server

    1982-01-01

    Parallel Computations focuses on parallel computation, with emphasis on algorithms used in a variety of numerical and physical applications and for many different types of parallel computers. Topics covered range from vectorization of fast Fourier transforms (FFTs) and of the incomplete Cholesky conjugate gradient (ICCG) algorithm on the Cray-1 to calculation of table lookups and piecewise functions. Single tridiagonal linear systems and vectorized computation of reactive flow are also discussed.Comprised of 13 chapters, this volume begins by classifying parallel computers and describing techn

  8. Human Computation

    CERN Multimedia

    CERN. Geneva

    2008-01-01

    What if people could play computer games and accomplish work without even realizing it? What if billions of people collaborated to solve important problems for humanity or generate training data for computers? My work aims at a general paradigm for doing exactly that: utilizing human processing power to solve computational problems in a distributed manner. In particular, I focus on harnessing human time and energy for addressing problems that computers cannot yet solve. Although computers have advanced dramatically in many respects over the last 50 years, they still do not possess the basic conceptual intelligence or perceptual capabilities...

  9. Quantum computation

    International Nuclear Information System (INIS)

    Deutsch, D.

    1992-01-01

    As computers become ever more complex, they inevitably become smaller. This leads to a need for components which are fabricated and operate on increasingly smaller size scales. Quantum theory is already taken into account in microelectronics design. This article explores how quantum theory will need to be incorporated into computers in future in order to give them their components functionality. Computation tasks which depend on quantum effects will become possible. Physicists may have to reconsider their perspective on computation in the light of understanding developed in connection with universal quantum computers. (UK)

  10. Integrating computational methods to retrofit enzymes to synthetic pathways.

    Science.gov (United States)

    Brunk, Elizabeth; Neri, Marilisa; Tavernelli, Ivano; Hatzimanikatis, Vassily; Rothlisberger, Ursula

    2012-02-01

    Microbial production of desired compounds provides an efficient framework for the development of renewable energy resources. To be competitive to traditional chemistry, one requirement is to utilize the full capacity of the microorganism to produce target compounds with high yields and turnover rates. We use integrated computational methods to generate and quantify the performance of novel biosynthetic routes that contain highly optimized catalysts. Engineering a novel reaction pathway entails addressing feasibility on multiple levels, which involves handling the complexity of large-scale biochemical networks while respecting the critical chemical phenomena at the atomistic scale. To pursue this multi-layer challenge, our strategy merges knowledge-based metabolic engineering methods with computational chemistry methods. By bridging multiple disciplines, we provide an integral computational framework that could accelerate the discovery and implementation of novel biosynthetic production routes. Using this approach, we have identified and optimized a novel biosynthetic route for the production of 3HP from pyruvate. Copyright © 2011 Wiley Periodicals, Inc.

  11. Thermal Evolution of Juvenile Subduction Zones ' New Constraints from Lu-Hf Geochronology on HP oceanic rocks (Halilbaǧi, Central Anatolia)

    Science.gov (United States)

    Pourteau, Amaury; Scherer, Erik; Schmidt, Alexander; Bast, Rebecca

    2015-04-01

    The thermal structure of subduction zones plays a key role on mechanical and chemical processes taking place along the slab-mantle interface. Until now, changes through time of this thermal structure have been explored mostly by the means of numerical simulations. However, both "warm" (i.e., epidote-bearing), and "cold" (i.e., lawsonite-bearing) HP oceanic rocks have been reported in some fossil subduction complexes exposed at the Earth's surface (e.g., Franciscan Complex, California; Rio San Juan Complex, Hispañola; Halilbağı Unit, Central Anatolia). These a-priori "incompatible" rocks witness different thermal stages of ancient subduction zones and their study might provide complementary constraints to numerical models. To decipher the meaning of these contrasting metamorphic rocks in the Halilbağı Unit, we are carrying out Lu-Hf geochronology on garnet (grt) and lws from a variety of HP oceanic rocks, as well as the metamorphic sole of the overlying ophiolite. We selected five samples that are representative of the variety of metamorphic evolutions (i.e. peak conditions and P-T paths) encountered in this area. Preliminary analyses yielded 110 Ma (grt-hbl isochron) for a sub-ophiolitic grt amphibolite; 92 Ma (grt-omp) for an eclogite with prograde and retrograde ep; 90 Ma (grt-omp) for an eclogitic metabasite with prograde ep and retrograde ep+lws; 87 Ma (grt-gln) for a lws eclogite with prograde ep; and 86 Ma (grt-gln) for a blueschist with prograde and retrograde lws. These ages are mainly two-point isochrons. Further-refined data will be presented at the EGU General Assembly 2015, in Vienna. The consistent younging trend from "warm" to "cold" metamorphic rocks revealed by these first-order results points to metamorphic-sole formation during the initiation of intra-oceanic subduction at ~110 Ma, and subsequent cooling of the slab-mantle interface between 92 and 86 Ma. Therefore, the contrasting metamorphic evolutions encountered in the Halilbağı Unit

  12. Computer software.

    Science.gov (United States)

    Rosenthal, L E

    1986-10-01

    Software is the component in a computer system that permits the hardware to perform the various functions that a computer system is capable of doing. The history of software and its development can be traced to the early nineteenth century. All computer systems are designed to utilize the "stored program concept" as first developed by Charles Babbage in the 1850s. The concept was lost until the mid-1940s, when modern computers made their appearance. Today, because of the complex and myriad tasks that a computer system can perform, there has been a differentiation of types of software. There is software designed to perform specific business applications. There is software that controls the overall operation of a computer system. And there is software that is designed to carry out specialized tasks. Regardless of types, software is the most critical component of any computer system. Without it, all one has is a collection of circuits, transistors, and silicone chips.

  13. Computer sciences

    Science.gov (United States)

    Smith, Paul H.

    1988-01-01

    The Computer Science Program provides advanced concepts, techniques, system architectures, algorithms, and software for both space and aeronautics information sciences and computer systems. The overall goal is to provide the technical foundation within NASA for the advancement of computing technology in aerospace applications. The research program is improving the state of knowledge of fundamental aerospace computing principles and advancing computing technology in space applications such as software engineering and information extraction from data collected by scientific instruments in space. The program includes the development of special algorithms and techniques to exploit the computing power provided by high performance parallel processors and special purpose architectures. Research is being conducted in the fundamentals of data base logic and improvement techniques for producing reliable computing systems.

  14. Computer programming and computer systems

    CERN Document Server

    Hassitt, Anthony

    1966-01-01

    Computer Programming and Computer Systems imparts a "reading knowledge? of computer systems.This book describes the aspects of machine-language programming, monitor systems, computer hardware, and advanced programming that every thorough programmer should be acquainted with. This text discusses the automatic electronic digital computers, symbolic language, Reverse Polish Notation, and Fortran into assembly language. The routine for reading blocked tapes, dimension statements in subroutines, general-purpose input routine, and efficient use of memory are also elaborated.This publication is inten

  15. Efficient computations of three-dimensional fluid-structure interactions during blowdown of a pressurized water reactor - FLUX

    International Nuclear Information System (INIS)

    Schumann, U.

    1979-01-01

    A numerical method (computer program FLUX) for investigation of the loads on pressure vessel internal structures during a loss-of-coolant accident of a PWR is described. In particular, the deformation of the core barrel are determined. Under operating conditions the core barrel controls the flow path in the vessel and consists mainly out of a relatively thin cylindrical shell. (orig./HP) [de

  16. Occurrence of tephra/volcanic tuff in the tertiary sediments of Himachal Himalaya from Tileli area, Mandi district, H.P.: implication for stratigraphy and uranium mineralization

    International Nuclear Information System (INIS)

    Pandey, Pradeep; Chabbra, Jyotsana; Joshi, G.B.; Parihar, P.S.

    2014-01-01

    Presence of Early Tertiary pyroclastic material (tephra) has been documented petrographically, for the first time, in the Mandi-Bilaspur Sector from Tileli area, Dharamsala basin of Himachal Pradesh. The tephra is reported from the red shale, identified as tuffaceous siltstone belonging to lower Dharamsala Formation that lies above the uraniferous sandstone body and occurs as thin layers of over 300m along the strike, close to the contact of lower and upper Dharamsala formations. The tuffaceous material shows crude but preferred orientation of minerals like biotite, muscovite, chlorite, clay, hematite and specularite. Various features indicating presence of tephra are, glass shards altered to clay but retaining 'U' shaped outline, spindle-shaped hematite with preferred orientation, spherical to sub-spherical clay and altered Fe oxide rich balls, clay groundmass with flow pattern, flaky minerals in association with clast depicting asymmetrical ramp structure. A zone of approximately 300 m length containing tuffaceous material has been established at Tileli overlying the uraniferous sandstone body. Identification of tephra at Tileli has significant implications as it enabled in demarcating the boundary between the upper and lower Dharamsala formations in central part of the basin in Bilaspur-Mandi Sector of HP Himalaya and also in guiding the uranium exploration programme in the lower Dharamsala Formation. (author)

  17. Analisis Peta Persepsi Pemilihan Atribut Produk Laptop Di Kalangan Mahasiswa Universitas Telkom Kota Bandung (Studi Pada Laptop Acer, Asus, Lenovo, Toshiba, HP, Samsung dan Apple

    Directory of Open Access Journals (Sweden)

    Wiwik Melwinda

    2017-04-01

    Full Text Available This research aims to find out laptop brand selection perceptual map of among Telkom University students. The object of this research study are some of incoming laptop brand in Top Brand 2016 which are Acer, Lenovo, Asus, Toshiba, HP, Samsung and Apple. The attributes of the study are design instrument, operation system, variation, feature set, specification, processor, battery resistance, product price, price resale, warranty, LCD display, storage capacity, product quality, sustainability to defect, and keyboard quality. This research used quantitative method. Research instrument used was a questionnaire, which distributed to 100 respondent sample area of the object of research. In taking a sample of this study, the researcher used Non-Probability technique by using purposive sampling method. The data analysis that used is multidimensional scalling analysis, this analysis gives perception map picture, appeared the position of each laptop brand that is close together or far apart. Laptop brand that showed in a perceptual map will display rank of the best position than another laptop brand. As perception, Apple occupies the first best position among another best laptop brands. That is proved by the rank position from respondents preference based on overall attributes which is more excellent in design, operation system, variation, feature set, specification, processor, battery resistance, product quality, and keyboard quality. For price product attribute is occupied by Lenovo as the cheapest rather than another laptop brands. Meanwhile, for the LCD display attribute, price resale, and storage capacity are occupied by Asus which get the second best rank based overall attribute.

  18. Structure, texture, and mechanical properties of an MA2-1hp magnesium alloy after two-stage equal-channel angular pressing and intermediate annealing

    Science.gov (United States)

    Serebryany, V. N.; Perezhogin, V. Yu.; Raab, G. I.; Kopylov, V. I.; Tabachkova, N. Yu.; Sirotinkin, V. P.; Dobatkin, S. V.

    2015-01-01

    The effect of two-stage equal-channel angular pressing (ECAP) on the microstructure, the texture, and the mechanical properties of an MA2-1hp magnesium alloy is analyzed. ECAP leads to the formation of a submicrocrystalline structure with an average grain size of 640 nm, which includes Mg17Al12 phase particles with an average grain size of 240 nm and a volume fracture of 5.5%. A scattered tilted basal texture forms after ECAP, and its experimental pole figures are used for calculating orientation distribution functions and determining the volume fractions of the main orientations and the Schmid factors for different deformation systems. An increased activation of basal slip is found after both the first and the second stages of ECAP. As a result of two-stage ECAP, the strength properties of the alloy that correspond to the minimum acceptable values achieved by direct compression are obtained. Ductility is 44 and 18% after the first stage of ECAP plus subsequent annealing and after the second stage, respectively, which is almost four and two times higher than the initial value. The resulting strength mechanical properties of the alloy after the first and the second ECAP stages are analyzed using the Hall-Petch relation.

  19. Simultaneous frequency stabilization and high-power dense wavelength division multiplexing (HP-DWDM) using an external cavity based on volume Bragg gratings (VBGs)

    Science.gov (United States)

    Hengesbach, Stefan; Klein, Sarah; Holly, Carlo; Witte, Ulrich; Traub, Martin; Hoffmann, Dieter

    2016-03-01

    Multiplexing technologies enable the development of high-brightness diode lasers for direct industrial applications. We present a High-Power Dense Wavelength Division Multiplexer (HP-DWDM) with an average channel spacing of 1.7 (1.5) nm and a subsequent external cavity mirror to provide feedback for frequency stabilization and multiplexing in one step. The "self-optimizing" multiplexing unit consists of four reflective Volume Bragg Gratings (VBGs) with 99% diffraction efficiency and seven dielectric mirrors to overlay the radiation of five input channels with an adjustable channel spacing of 1-2 nm. In detail, we focus on the analysis of the overall optical efficiency, the change of the beam parameter product and the spectral width. The performance is demonstrated using five 90 μm multimode 9xx single emitters with M2angular intensity distribution changes strongly and the beam parameter product decreases by a factor of 1.2 to 1.9. Thereby the angular intensity distribution is more affected than the width of the beam waist. The spectral width per emitter decreases to 3-200 pm (FWHM) depending on the injection current and the reflectance of the feedback mirror (0.75%, 1.5%, 4%, 6% or 8%). The overall optical multiplexing efficiency ranges between 77% and 86%. With some modifications (e.g. enhanced AR-coatings) we expect 90-95%.

  20. Research of ALA combined with HpD-PDT which induced s180 ascitic tumor cells, death or apoptosis on cytology

    Science.gov (United States)

    Zhu, Jing; Yan, Min; Zhang, Hui-Guo; Li, Enling; Luo, Hongyu

    2005-07-01

    To ascertain the adequate dosage of ALA combined with HpD-PDT which induced tumor cell death or apoptosis on cytology. And to study the different effect of ALA-PDT and HPD-PDT used only. Rat ascitic tumor cells(S180) were randomly divided into several groups and incubated with ALA(20μg/ml 、40μg/ml、80μg/ml 、160μg/ml)、HPD(2.5μg/ml、5μg/ml、10μg/ml)and their combination dosages. 630nm light (total output 2W) was delivered to tumor cells at a constant fluence rate: 200mw/cm2 and a constant irradiated time period: 20 minutes. We set 3 groups (no photosensitizers or no irradiation or neither) to be the control groups. We used inversion microscopy to observe the morphological change of tumor cells and flow cytometry technology to detect the death or apoptosis of tumor cells during the experiment. ..

  1. Formation of Microcracks During Micro-Arc Oxidation in a Phytic Acid-Containing Solution on Two-Phase AZ91HP

    Science.gov (United States)

    Zhang, R. F.; Chang, W. H.; Jiang, L. F.; Qu, B.; Zhang, S. F.; Qiao, L. P.; Xiang, J. H.

    2016-04-01

    Micro-arc oxidation (MAO) is an effective method to produce ceramic coatings on magnesium alloys and can considerably improve their corrosion resistance. The coating properties are closely related with microcracks, which are always inevitably developed on the coating surface. In order to find out the formation and development regularity of microcracks, anodic coatings developed on two-phase AZ91HP after different anodizing times were fabricated in a solution containing environmentally friendly organic electrolyte phytic acid. The results show that anodic film is initially developed on the α phase. At 50 s, anodic coatings begin to develop on the β phase, evidencing the formation of a rough area. Due to the coating successive development, the microcracks initially appear at the boundary between the initially formed coating on the α phase and the subsequently developed coating on the β phase. With the prolonging treatment time, the microcracks near the β phase become evident. After treating for 3 min, the originally rough area on the β phase disappears and the coatings become almost uniform with microcracks randomly distributed on the sample surface. Inorganic phosphates are found in MAO coatings, suggesting that phytate salts are decomposed due to the high instantaneous temperature on the sample surface resulted from spark discharge.

  2. MCNP SIMULATION OF THE HP(10) ENERGY RESPONSE OF A BRAZILIAN TLD ALBEDO NEUTRON INDIVIDUAL DOSEMETER, FROM THERMAL TO 20 MeV.

    Science.gov (United States)

    Freitas, B M; Martins, M M; Pereira, W W; da Silva, A X; Mauricio, C L P

    2016-09-01

    The Brazilian Instituto de Radioproteção e Dosimetria (IRD) runs a neutron individual monitoring system with a home-made TLD albedo dosemeter. It has already been characterised and calibrated in some reference fields. However, the complete energy response of this dosemeter is not known, and the calibration factors for all monitored workplace neutron fields are difficult to be obtained experimentally. Therefore, to overcome such difficulties, Monte Carlo simulations have been used. This paper describes the simulation of the HP(10) neutron response of the IRD TLD albedo dosemeter using the MCNPX transport code, for energies from thermal to 20 MeV. The validation of the MCNPX modelling is done comparing the simulated results with the experimental measurements for ISO standard neutron fields of (241)Am-Be, (252)Cf, (241)Am-B and (252)Cf(D2O) and also for (241)Am-Be source moderated with paraffin and silicone. Bare (252)Cf are used for normalisation. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  3. Study of the kinematically complete breakup reaction 2H(p vector, pp)n at Ep=13.0 MeV with polarized protons

    International Nuclear Information System (INIS)

    Rauprich, G.; Lemaitre, S.; Niessen, P.; Nyga, K.R.; Reckenfelderbaeumer, R.; Sydow, L.; Paetz genannt Schieck, H.; Witala, H.; Gloeckle, W.

    1991-01-01

    The breakup reaction 2 H(p vector,pp)n at E p =13.0 MeV has been measured in a kinematically complete experiment with polarized protons in four special kinematical situations: np final-state interaction, pp quasi-free scattering, collinearity and symmetric space star. These configurations are identical to those of a corresponding 2 H(n,nn) 1 H experiment. The cross sections d 3 σ/dΩ 3 dΩ 4 dS and the vector analyzing powers A y are presented as a function of the arclength of the relevant kinematical loci. They are compared to the rigorous Faddeev calculations using realistic meson-exchange NN potentials, i.e. the Paris and Bonn potential. Comparison with the cross section data of the analog neutron experiment is made. In the quasi-free scattering and the space-star cross sections marked discrepancies with the theoretical predictions, in the latter case also with the neutron results are found. In the collinear and final-state interaction situations the agreement is rather good as well as for all analyzing powers and is even improved by taking the finite angular spread into account. (orig.)

  4. Effect of seawater salinity on pore-size distribution on a poly(styrene)-based HP20 resin and its adsorption of diarrhetic shellfish toxins.

    Science.gov (United States)

    Fan, Lin; Sun, Geng; Qiu, Jiangbing; Ma, Qimin; Hess, Philipp; Li, Aifeng

    2014-12-19

    In the present study, okadaic acid (OA) and dinophysistoxin-1 (DTX1) were spiked into artificial seawater at low, medium and high estuarine salinities (9‰, 13.5‰ and 27‰). Passive samplers (HP20 resin) used for solid phase adsorption toxin tracking (SPATT) technology were exposed in these seawaters for 12-h periods. Adsorption curves well fitted a pseudo-secondary kinetics model. The highest initial sorption rates of both toxins occurred in the seawater of medium salinity, followed by seawater of low and high estuarine salinity. Pore volumes of micropores (seawater at high and low salinity but not in seawater at medium salinity, which demonstrated that the toxin molecules entered into micropores and mesopores (below 10nm in size) in seawaters of high and low salinity. More toxin or other matrix agglomerates were displayed on the surface of resin deployed in the seawater of medium salinity. Taking into consideration the pore-size distribution and surface images, it appears that intra-particle diffusion governs toxin adsorption in seawater at high salinity while film diffusion mainly controls the adsorption process in seawater at medium salinity. This is the first study to confirm that molecules of OA and DTX1 are able to enter into micropores (seawater with high salinity (∼27‰). Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Analysis of the reasons for failures of the 1500 MW turbines HP diaphragms on the EDF N4 units. Implementation of a solution

    International Nuclear Information System (INIS)

    Franc, J. C.; Franconville, M.

    2002-01-01

    The full text follows. Diaphragms are major components of an impulse type steam turbine since they hold the fixed blades which allow part of the steam expansion (the other part being on the moving blades mounted on the rotor) The 4 impulse type 1500 MW nuclear steam turbines, from the EDF N4 program,were commissioned in 1996 on the CHOOZ and then CIVAUX plants.The diaphragms, located in the HP(high pressure) part of these turbines, have shown signs of failures very soon, due to a cracking of assembly welds,which is dangerous for the machines integrity. These failures questioned a construction mode which had been highly experienced previously. A large campaign of inspections and tests was carried out to feature the ways of failure,on site or in the factory during manufacturing.Site measurements combined with numerical simulations allowed to define excitations, harmful to these components,during operation. Temporary solutions were applied in order to allow immediate restart of the plants.In parallel,a modification of the diaphragms design and assembly method was studied and applied to withstand the various operating stresses. (author)

  6. Microcomputers, desk calculators and process computers for use in radiation protection

    International Nuclear Information System (INIS)

    Burgkhardt, B.; Nolte, G.; Schollmeier, W.; Rau, G.

    1983-01-01

    The goals achievable, or to be pursued, in radiation protection measurement and evaluation by using computers are explained. As there is a large variety of computers available offering a likewise large variety, of performances, use of a computer is justified even for minor measuring and evaluation tasks. The subdivision into: Microcomputers as an installed part of measuring equipment; measuring and evaluation systems with desk calculators; measuring and evaluation systems with process computers is done to explain the importance and extent of the measuring or evaluation tasks and the computing devices suitable for the various purposes. The special requirements to be met in order to fulfill the different tasks are discussed, both in terms of hardware and software and in terms of skill and knowledge of the personnel, and are illustrated by an example showing the usefulness of computers in radiation protection. (orig./HP) [de

  7. Design tools for computer-generated display of information to operators

    International Nuclear Information System (INIS)

    O'Brien, J.F.; Cain, D.G.; Sun, B.K.H.

    1985-01-01

    More and more computers are being used to process and display information to operators who control nuclear power plants. Implementation of computer-generated displays in power plant control rooms represents a considerable design challenge for industry designers. Over the last several years, the EPRI has conducted research aimed at providing industry designers tools to meet this new design challenge. These tools provide guidance in defining more 'intelligent' information for plant control and in developing effective displays to communicate this information to the operators. (orig./HP)

  8. Organic Computing

    CERN Document Server

    Würtz, Rolf P

    2008-01-01

    Organic Computing is a research field emerging around the conviction that problems of organization in complex systems in computer science, telecommunications, neurobiology, molecular biology, ethology, and possibly even sociology can be tackled scientifically in a unified way. From the computer science point of view, the apparent ease in which living systems solve computationally difficult problems makes it inevitable to adopt strategies observed in nature for creating information processing machinery. In this book, the major ideas behind Organic Computing are delineated, together with a sparse sample of computational projects undertaken in this new field. Biological metaphors include evolution, neural networks, gene-regulatory networks, networks of brain modules, hormone system, insect swarms, and ant colonies. Applications are as diverse as system design, optimization, artificial growth, task allocation, clustering, routing, face recognition, and sign language understanding.

  9. Performance of scientific computing platforms with MCNP4B

    International Nuclear Information System (INIS)

    McLaughlin, H.E.; Hendricks, J.S.

    1998-01-01

    Several computing platforms were evaluated with the MCNP4B Monte Carlo radiation transport code. The DEC AlphaStation 500/500 was the fastest to run MCNP4B. Compared to the HP 9000-735, the fastest platform 4 yr ago, the AlphaStation is 335% faster, the HP C180 is 133% faster, the SGI Origin 2000 is 82% faster, the Cray T94/4128 is 1% faster, the IBM RS/6000-590 is 93% as fast, the DEC 3000/600 is 81% as fast, the Sun Sparc20 is 57% as fast, the Cray YMP 8/8128 is 57% as fast, the sun Sparc5 is 33% as fast, and the Sun Sparc2 is 13% as fast. All results presented are reproducible and allow for comparison to computer platforms not included in this study. Timing studies are seen to be very problem dependent. The performance gains resulting from advances in software were also investigated. Various compilers and operating systems were seen to have a modest impact on performance, whereas hardware improvements have resulted in a factor of 4 improvement. MCNP4B also ran approximately as fast as MCNP4A

  10. Computational biomechanics

    International Nuclear Information System (INIS)

    Ethier, C.R.

    2004-01-01

    Computational biomechanics is a fast-growing field that integrates modern biological techniques and computer modelling to solve problems of medical and biological interest. Modelling of blood flow in the large arteries is the best-known application of computational biomechanics, but there are many others. Described here is work being carried out in the laboratory on the modelling of blood flow in the coronary arteries and on the transport of viral particles in the eye. (author)

  11. Computational Composites

    DEFF Research Database (Denmark)

    Vallgårda, Anna K. A.

    to understand the computer as a material like any other material we would use for design, like wood, aluminum, or plastic. That as soon as the computer forms a composition with other materials it becomes just as approachable and inspiring as other smart materials. I present a series of investigations of what...... Computational Composite, and Telltale). Through the investigations, I show how the computer can be understood as a material and how it partakes in a new strand of materials whose expressions come to be in context. I uncover some of their essential material properties and potential expressions. I develop a way...

  12. GPGPU COMPUTING

    Directory of Open Access Journals (Sweden)

    BOGDAN OANCEA

    2012-05-01

    Full Text Available Since the first idea of using GPU to general purpose computing, things have evolved over the years and now there are several approaches to GPU programming. GPU computing practically began with the introduction of CUDA (Compute Unified Device Architecture by NVIDIA and Stream by AMD. These are APIs designed by the GPU vendors to be used together with the hardware that they provide. A new emerging standard, OpenCL (Open Computing Language tries to unify different GPU general computing API implementations and provides a framework for writing programs executed across heterogeneous platforms consisting of both CPUs and GPUs. OpenCL provides parallel computing using task-based and data-based parallelism. In this paper we will focus on the CUDA parallel computing architecture and programming model introduced by NVIDIA. We will present the benefits of the CUDA programming model. We will also compare the two main approaches, CUDA and AMD APP (STREAM and the new framwork, OpenCL that tries to unify the GPGPU computing models.

  13. Quantum Computing

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 9. Quantum Computing - Building Blocks of a Quantum Computer. C S Vijay Vishal Gupta. General Article Volume 5 Issue 9 September 2000 pp 69-81. Fulltext. Click here to view fulltext PDF. Permanent link:

  14. Platform computing

    CERN Multimedia

    2002-01-01

    "Platform Computing releases first grid-enabled workload management solution for IBM eServer Intel and UNIX high performance computing clusters. This Out-of-the-box solution maximizes the performance and capability of applications on IBM HPC clusters" (1/2 page) .

  15. Quantum Computing

    Indian Academy of Sciences (India)

    In the first part of this article, we had looked at how quantum physics can be harnessed to make the building blocks of a quantum computer. In this concluding part, we look at algorithms which can exploit the power of this computational device, and some practical difficulties in building such a device. Quantum Algorithms.

  16. Quantum computing

    OpenAIRE

    Burba, M.; Lapitskaya, T.

    2017-01-01

    This article gives an elementary introduction to quantum computing. It is a draft for a book chapter of the "Handbook of Nature-Inspired and Innovative Computing", Eds. A. Zomaya, G.J. Milburn, J. Dongarra, D. Bader, R. Brent, M. Eshaghian-Wilner, F. Seredynski (Springer, Berlin Heidelberg New York, 2006).

  17. Computational Pathology

    Science.gov (United States)

    Louis, David N.; Feldman, Michael; Carter, Alexis B.; Dighe, Anand S.; Pfeifer, John D.; Bry, Lynn; Almeida, Jonas S.; Saltz, Joel; Braun, Jonathan; Tomaszewski, John E.; Gilbertson, John R.; Sinard, John H.; Gerber, Georg K.; Galli, Stephen J.; Golden, Jeffrey A.; Becich, Michael J.

    2016-01-01

    Context We define the scope and needs within the new discipline of computational pathology, a discipline critical to the future of both the practice of pathology and, more broadly, medical practice in general. Objective To define the scope and needs of computational pathology. Data Sources A meeting was convened in Boston, Massachusetts, in July 2014 prior to the annual Association of Pathology Chairs meeting, and it was attended by a variety of pathologists, including individuals highly invested in pathology informatics as well as chairs of pathology departments. Conclusions The meeting made recommendations to promote computational pathology, including clearly defining the field and articulating its value propositions; asserting that the value propositions for health care systems must include means to incorporate robust computational approaches to implement data-driven methods that aid in guiding individual and population health care; leveraging computational pathology as a center for data interpretation in modern health care systems; stating that realizing the value proposition will require working with institutional administrations, other departments, and pathology colleagues; declaring that a robust pipeline should be fostered that trains and develops future computational pathologists, for those with both pathology and non-pathology backgrounds; and deciding that computational pathology should serve as a hub for data-related research in health care systems. The dissemination of these recommendations to pathology and bioinformatics departments should help facilitate the development of computational pathology. PMID:26098131

  18. Cloud Computing

    DEFF Research Database (Denmark)

    Krogh, Simon

    2013-01-01

    with technological changes, the paradigmatic pendulum has swung between increased centralization on one side and a focus on distributed computing that pushes IT power out to end users on the other. With the introduction of outsourcing and cloud computing, centralization in large data centers is again dominating...... the IT scene. In line with the views presented by Nicolas Carr in 2003 (Carr, 2003), it is a popular assumption that cloud computing will be the next utility (like water, electricity and gas) (Buyya, Yeo, Venugopal, Broberg, & Brandic, 2009). However, this assumption disregards the fact that most IT production......), for instance, in establishing and maintaining trust between the involved parties (Sabherwal, 1999). So far, research in cloud computing has neglected this perspective and focused entirely on aspects relating to technology, economy, security and legal questions. While the core technologies of cloud computing (e...

  19. Computability theory

    CERN Document Server

    Weber, Rebecca

    2012-01-01

    What can we compute--even with unlimited resources? Is everything within reach? Or are computations necessarily drastically limited, not just in practice, but theoretically? These questions are at the heart of computability theory. The goal of this book is to give the reader a firm grounding in the fundamentals of computability theory and an overview of currently active areas of research, such as reverse mathematics and algorithmic randomness. Turing machines and partial recursive functions are explored in detail, and vital tools and concepts including coding, uniformity, and diagonalization are described explicitly. From there the material continues with universal machines, the halting problem, parametrization and the recursion theorem, and thence to computability for sets, enumerability, and Turing reduction and degrees. A few more advanced topics round out the book before the chapter on areas of research. The text is designed to be self-contained, with an entire chapter of preliminary material including re...

  20. Computational Streetscapes

    Directory of Open Access Journals (Sweden)

    Paul M. Torrens

    2016-09-01

    Full Text Available Streetscapes have presented a long-standing interest in many fields. Recently, there has been a resurgence of attention on streetscape issues, catalyzed in large part by computing. Because of computing, there is more understanding, vistas, data, and analysis of and on streetscape phenomena than ever before. This diversity of lenses trained on streetscapes permits us to address long-standing questions, such as how people use information while mobile, how interactions with people and things occur on streets, how we might safeguard crowds, how we can design services to assist pedestrians, and how we could better support special populations as they traverse cities. Amid each of these avenues of inquiry, computing is facilitating new ways of posing these questions, particularly by expanding the scope of what-if exploration that is possible. With assistance from computing, consideration of streetscapes now reaches across scales, from the neurological interactions that form among place cells in the brain up to informatics that afford real-time views of activity over whole urban spaces. For some streetscape phenomena, computing allows us to build realistic but synthetic facsimiles in computation, which can function as artificial laboratories for testing ideas. In this paper, I review the domain science for studying streetscapes from vantages in physics, urban studies, animation and the visual arts, psychology, biology, and behavioral geography. I also review the computational developments shaping streetscape science, with particular emphasis on modeling and simulation as informed by data acquisition and generation, data models, path-planning heuristics, artificial intelligence for navigation and way-finding, timing, synthetic vision, steering routines, kinematics, and geometrical treatment of collision detection and avoidance. I also discuss the implications that the advances in computing streetscapes might have on emerging developments in cyber

  1. COMPUTATIONAL THINKING

    Directory of Open Access Journals (Sweden)

    Evgeniy K. Khenner

    2016-01-01

    Full Text Available Abstract. The aim of the research is to draw attention of the educational community to the phenomenon of computational thinking which actively discussed in the last decade in the foreign scientific and educational literature, to substantiate of its importance, practical utility and the right on affirmation in Russian education.Methods. The research is based on the analysis of foreign studies of the phenomenon of computational thinking and the ways of its formation in the process of education; on comparing the notion of «computational thinking» with related concepts used in the Russian scientific and pedagogical literature.Results. The concept «computational thinking» is analyzed from the point of view of intuitive understanding and scientific and applied aspects. It is shown as computational thinking has evolved in the process of development of computers hardware and software. The practice-oriented interpretation of computational thinking which dominant among educators is described along with some ways of its formation. It is shown that computational thinking is a metasubject result of general education as well as its tool. From the point of view of the author, purposeful development of computational thinking should be one of the tasks of the Russian education.Scientific novelty. The author gives a theoretical justification of the role of computational thinking schemes as metasubject results of learning. The dynamics of the development of this concept is described. This process is connected with the evolution of computer and information technologies as well as increase of number of the tasks for effective solutions of which computational thinking is required. Author substantiated the affirmation that including «computational thinking » in the set of pedagogical concepts which are used in the national education system fills an existing gap.Practical significance. New metasubject result of education associated with

  2. Energy Efficiency in Computing (1/2)

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    As manufacturers improve the silicon process, truly low energy computing is becoming a reality - both in servers and in the consumer space. This series of lectures covers a broad spectrum of aspects related to energy efficient computing - from circuits to datacentres. We will discuss common trade-offs and basic components, such as processors, memory and accelerators. We will also touch on the fundamentals of modern datacenter design and operation. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP and Google), as well as international research institutes, such as EPFL. Currently, Andrzej acts as a consultant on technology and innovation with TIK Services (http://tik.services), and runs a peer-to-peer lending start-up. NB! All Academic L...

  3. Future Computing Technology (1/3)

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Computing of the future will be affected by a number of fundamental technologies in development today, many of which are already on the way to becoming commercialized. In this series of lectures, we will discuss hardware and software development that will become mainstream in the timeframe of a few years and how they will shape or change the computing landscape - commercial and personal alike. Topics range from processor and memory aspects, programming models and the limits of artificial intelligence, up to end-user interaction with wearables or e-textiles. We discuss the impact of these technologies on the art of programming, the data centres of the future and daily life. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP and Go...

  4. Progression of emphysema evaluated by MRI using hyperpolarized (3)He (HP (3)He) measurements in patients with alpha-1-antitrypsin (A1AT) deficiency compared with CT and lung function tests

    DEFF Research Database (Denmark)

    Stavngaard, T; Søgaard, L Vejby; Batz, M

    2009-01-01

    BACKGROUND: The progression of emphysema is traditionally measured by pulmonary function test, with forced expiratory volume in 1 s (FEV(1)) being the most accepted and used measurement. However, FEV(1) is insensitive in detecting mild/slow progression of emphysema because of low reproducibility...... as compared to yearly decline. PURPOSE: To investigate the progression of emphysema over a period of 2 years using diffusion-weighted hyperpolarized (HP) (3)He magnetic resonance imaging (MRI) in patients with alpha-1-antitrypsin (A1AT) deficiency. MATERIAL AND METHODS: Nine patients with severe A1AT...... density [CT-PD15] and relative area of emphysema below -910 HU [CT-RA-910]). RESULTS: Seven patients were scanned three times, one patient two times, and one patient only at baseline. The mean increase in ADC values from first to last HP (3)He MR scanning was 3.8% (0.014 cm(2)/s [SD 0.024 cm(2)/s...

  5. Computer interfacing

    CERN Document Server

    Dixey, Graham

    1994-01-01

    This book explains how computers interact with the world around them and therefore how to make them a useful tool. Topics covered include descriptions of all the components that make up a computer, principles of data exchange, interaction with peripherals, serial communication, input devices, recording methods, computer-controlled motors, and printers.In an informative and straightforward manner, Graham Dixey describes how to turn what might seem an incomprehensible 'black box' PC into a powerful and enjoyable tool that can help you in all areas of your work and leisure. With plenty of handy

  6. Computational physics

    CERN Document Server

    Newman, Mark

    2013-01-01

    A complete introduction to the field of computational physics, with examples and exercises in the Python programming language. Computers play a central role in virtually every major physics discovery today, from astrophysics and particle physics to biophysics and condensed matter. This book explains the fundamentals of computational physics and describes in simple terms the techniques that every physicist should know, such as finite difference methods, numerical quadrature, and the fast Fourier transform. The book offers a complete introduction to the topic at the undergraduate level, and is also suitable for the advanced student or researcher who wants to learn the foundational elements of this important field.

  7. Computational physics

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1987-01-15

    Computers have for many years played a vital role in the acquisition and treatment of experimental data, but they have more recently taken up a much more extended role in physics research. The numerical and algebraic calculations now performed on modern computers make it possible to explore consequences of basic theories in a way which goes beyond the limits of both analytic insight and experimental investigation. This was brought out clearly at the Conference on Perspectives in Computational Physics, held at the International Centre for Theoretical Physics, Trieste, Italy, from 29-31 October.

  8. Cloud Computing

    CERN Document Server

    Baun, Christian; Nimis, Jens; Tai, Stefan

    2011-01-01

    Cloud computing is a buzz-word in today's information technology (IT) that nobody can escape. But what is really behind it? There are many interpretations of this term, but no standardized or even uniform definition. Instead, as a result of the multi-faceted viewpoints and the diverse interests expressed by the various stakeholders, cloud computing is perceived as a rather fuzzy concept. With this book, the authors deliver an overview of cloud computing architecture, services, and applications. Their aim is to bring readers up to date on this technology and thus to provide a common basis for d

  9. Computational Viscoelasticity

    CERN Document Server

    Marques, Severino P C

    2012-01-01

    This text is a guide how to solve problems in which viscoelasticity is present using existing commercial computational codes. The book gives information on codes’ structure and use, data preparation  and output interpretation and verification. The first part of the book introduces the reader to the subject, and to provide the models, equations and notation to be used in the computational applications. The second part shows the most important Computational techniques: Finite elements formulation, Boundary elements formulation, and presents the solutions of Viscoelastic problems with Abaqus.

  10. Optical computing.

    Science.gov (United States)

    Stroke, G. W.

    1972-01-01

    Applications of the optical computer include an approach for increasing the sharpness of images obtained from the most powerful electron microscopes and fingerprint/credit card identification. The information-handling capability of the various optical computing processes is very great. Modern synthetic-aperture radars scan upward of 100,000 resolvable elements per second. Fields which have assumed major importance on the basis of optical computing principles are optical image deblurring, coherent side-looking synthetic-aperture radar, and correlative pattern recognition. Some examples of the most dramatic image deblurring results are shown.

  11. Computational physics

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    Computers have for many years played a vital role in the acquisition and treatment of experimental data, but they have more recently taken up a much more extended role in physics research. The numerical and algebraic calculations now performed on modern computers make it possible to explore consequences of basic theories in a way which goes beyond the limits of both analytic insight and experimental investigation. This was brought out clearly at the Conference on Perspectives in Computational Physics, held at the International Centre for Theoretical Physics, Trieste, Italy, from 29-31 October

  12. Phenomenological Computation?

    DEFF Research Database (Denmark)

    Brier, Søren

    2014-01-01

    Open peer commentary on the article “Info-computational Constructivism and Cognition” by Gordana Dodig-Crnkovic. Upshot: The main problems with info-computationalism are: (1) Its basic concept of natural computing has neither been defined theoretically or implemented practically. (2. It cannot...... encompass human concepts of subjective experience and intersubjective meaningful communication, which prevents it from being genuinely transdisciplinary. (3) Philosophically, it does not sufficiently accept the deep ontological differences between various paradigms such as von Foerster’s second- order...

  13. Microscopic calculation of the molecular-nuclear D+D → sup(3)He+n and D+D → sup(3)H+p reactions at close to zero energies

    International Nuclear Information System (INIS)

    Frederico, T.; Groote, J.J. de; Hornos, J.E.; Hussein, M.S.

    1990-11-01

    Microscopic calculations of the astrophysically interesting reactions D+D→sup(3)He+n and D+D→sup(3)H+p are performed using nuclear reaction theory and Born-Oppenheimer type molecular calculation of the D+D initial stage. The sensitivity of the fusion rate to the behaviour of the D+D wave function at close to zero separation is assessed. Relevance of the results to the cold fusion problem is discussed. (author)

  14. Essentials of cloud computing

    CERN Document Server

    Chandrasekaran, K

    2014-01-01

    ForewordPrefaceComputing ParadigmsLearning ObjectivesPreambleHigh-Performance ComputingParallel ComputingDistributed ComputingCluster ComputingGrid ComputingCloud ComputingBiocomputingMobile ComputingQuantum ComputingOptical ComputingNanocomputingNetwork ComputingSummaryReview PointsReview QuestionsFurther ReadingCloud Computing FundamentalsLearning ObjectivesPreambleMotivation for Cloud ComputingThe Need for Cloud ComputingDefining Cloud ComputingNIST Definition of Cloud ComputingCloud Computing Is a ServiceCloud Computing Is a Platform5-4-3 Principles of Cloud computingFive Essential Charact

  15. Personal Computers.

    Science.gov (United States)

    Toong, Hoo-min D.; Gupta, Amar

    1982-01-01

    Describes the hardware, software, applications, and current proliferation of personal computers (microcomputers). Includes discussions of microprocessors, memory, output (including printers), application programs, the microcomputer industry, and major microcomputer manufacturers (Apple, Radio Shack, Commodore, and IBM). (JN)

  16. Computational Literacy

    DEFF Research Database (Denmark)

    Chongtay, Rocio; Robering, Klaus

    2016-01-01

    In recent years, there has been a growing interest in and recognition of the importance of Computational Literacy, a skill generally considered to be necessary for success in the 21st century. While much research has concentrated on requirements, tools, and teaching methodologies for the acquisit......In recent years, there has been a growing interest in and recognition of the importance of Computational Literacy, a skill generally considered to be necessary for success in the 21st century. While much research has concentrated on requirements, tools, and teaching methodologies...... for the acquisition of Computational Literacy at basic educational levels, focus on higher levels of education has been much less prominent. The present paper considers the case of courses for higher education programs within the Humanities. A model is proposed which conceives of Computational Literacy as a layered...

  17. Computing Religion

    DEFF Research Database (Denmark)

    Nielbo, Kristoffer Laigaard; Braxton, Donald M.; Upal, Afzal

    2012-01-01

    The computational approach has become an invaluable tool in many fields that are directly relevant to research in religious phenomena. Yet the use of computational tools is almost absent in the study of religion. Given that religion is a cluster of interrelated phenomena and that research...... concerning these phenomena should strive for multilevel analysis, this article argues that the computational approach offers new methodological and theoretical opportunities to the study of religion. We argue that the computational approach offers 1.) an intermediary step between any theoretical construct...... and its targeted empirical space and 2.) a new kind of data which allows the researcher to observe abstract constructs, estimate likely outcomes, and optimize empirical designs. Because sophisticated mulitilevel research is a collaborative project we also seek to introduce to scholars of religion some...

  18. Computational Controversy

    NARCIS (Netherlands)

    Timmermans, Benjamin; Kuhn, Tobias; Beelen, Kaspar; Aroyo, Lora

    2017-01-01

    Climate change, vaccination, abortion, Trump: Many topics are surrounded by fierce controversies. The nature of such heated debates and their elements have been studied extensively in the social science literature. More recently, various computational approaches to controversy analysis have

  19. Grid Computing

    Indian Academy of Sciences (India)

    IAS Admin

    emergence of supercomputers led to the use of computer simula- tion as an .... Scientific and engineering applications (e.g., Tera grid secure gate way). Collaborative ... Encryption, privacy, protection from malicious software. Physical Layer.

  20. Computer tomographs

    International Nuclear Information System (INIS)

    Niedzwiedzki, M.

    1982-01-01

    Physical foundations and the developments in the transmission and emission computer tomography are presented. On the basis of the available literature and private communications a comparison is made of the various transmission tomographs. A new technique of computer emission tomography ECT, unknown in Poland, is described. The evaluation of two methods of ECT, namely those of positron and single photon emission tomography is made. (author)

  1. Computational sustainability

    CERN Document Server

    Kersting, Kristian; Morik, Katharina

    2016-01-01

    The book at hand gives an overview of the state of the art research in Computational Sustainability as well as case studies of different application scenarios. This covers topics such as renewable energy supply, energy storage and e-mobility, efficiency in data centers and networks, sustainable food and water supply, sustainable health, industrial production and quality, etc. The book describes computational methods and possible application scenarios.

  2. Computing farms

    International Nuclear Information System (INIS)

    Yeh, G.P.

    2000-01-01

    High-energy physics, nuclear physics, space sciences, and many other fields have large challenges in computing. In recent years, PCs have achieved performance comparable to the high-end UNIX workstations, at a small fraction of the price. We review the development and broad applications of commodity PCs as the solution to CPU needs, and look forward to the important and exciting future of large-scale PC computing

  3. Computational chemistry

    Science.gov (United States)

    Arnold, J. O.

    1987-01-01

    With the advent of supercomputers, modern computational chemistry algorithms and codes, a powerful tool was created to help fill NASA's continuing need for information on the properties of matter in hostile or unusual environments. Computational resources provided under the National Aerodynamics Simulator (NAS) program were a cornerstone for recent advancements in this field. Properties of gases, materials, and their interactions can be determined from solutions of the governing equations. In the case of gases, for example, radiative transition probabilites per particle, bond-dissociation energies, and rates of simple chemical reactions can be determined computationally as reliably as from experiment. The data are proving to be quite valuable in providing inputs to real-gas flow simulation codes used to compute aerothermodynamic loads on NASA's aeroassist orbital transfer vehicles and a host of problems related to the National Aerospace Plane Program. Although more approximate, similar solutions can be obtained for ensembles of atoms simulating small particles of materials with and without the presence of gases. Computational chemistry has application in studying catalysis, properties of polymers, all of interest to various NASA missions, including those previously mentioned. In addition to discussing these applications of computational chemistry within NASA, the governing equations and the need for supercomputers for their solution is outlined.

  4. [Pr2(pdc3(Hpdc(H2O4]n·n(H3hp·8n(H2O, a One-Dimensional Coordination Polymer Containing PrO6N3 Tri-Capped Trigonal Prisms and PrO8N Mono-Capped Square Anti-Prisms (H2pdc = Pyridine 2,6-Dicarboxylic Acid, C7H5NO4; 3hp = 3-Hydroxy Pyridine, C5H5NO

    Directory of Open Access Journals (Sweden)

    Shahzad Sharif

    2012-08-01

    Full Text Available The synthesis, structure and some properties of the one-dimensional coordination polymer, [Pr2(pdc3(Hpdc]n·n(H3hp·8n(H2O, (H2pdc = pyridine 2,6-dicarboxylic acid, C7H5NO4; 3hp = 3-hydroxypyridine, C5H5NO are described. One of the Pr3+ ions is coordinated by two O,N,O-tridentate pdc2− ligands and one tridentate Hpdc− anion to generate a fairly regular PrO6N3 tri-capped trigonal prism, with the N atoms acting as the caps. The second Pr3+ ion is coordinated by one tridentate pdc2− dianion, four water molecules and two monodentate bridging pdc2− ligands to result in a PrO8N coordination polyhedron that approximates to a mono-capped square-anti-prism. The ligands bridge the metal-atom nodes into a chain, which extends in the [100] direction. The H3hp+ cation and uncoordinated water molecules occupy the inter-chain regions and an N–HLO and numerous O–HLO hydrogen bonds consolidate the structure. The H3hp+ species appears to intercalate between pendant pdc rings to consolidate the polymeric structure. Crystal data: 1 (C33H43N5O29Pr2, Mr = 1255.54, triclinic,  (No. 2, Z = 2, a = 13.2567(1 Å, b = 13.6304(2 Å, c = 13.6409(2 Å, α = 89.695(1°, β = 63.049(1°, γ = 86.105(1°, V = 2191.16(5 Å3, R(F = 0.033, wR(F2 = 0.084.

  5. Computational creativity

    Directory of Open Access Journals (Sweden)

    López de Mántaras Badia, Ramon

    2013-12-01

    Full Text Available New technologies, and in particular artificial intelligence, are drastically changing the nature of creative processes. Computers are playing very significant roles in creative activities such as music, architecture, fine arts, and science. Indeed, the computer is already a canvas, a brush, a musical instrument, and so on. However, we believe that we must aim at more ambitious relations between computers and creativity. Rather than just seeing the computer as a tool to help human creators, we could see it as a creative entity in its own right. This view has triggered a new subfield of Artificial Intelligence called Computational Creativity. This article addresses the question of the possibility of achieving computational creativity through some examples of computer programs capable of replicating some aspects of creative behavior in the fields of music and science.Las nuevas tecnologías y en particular la Inteligencia Artificial están cambiando de forma importante la naturaleza del proceso creativo. Los ordenadores están jugando un papel muy significativo en actividades artísticas tales como la música, la arquitectura, las bellas artes y la ciencia. Efectivamente, el ordenador ya es el lienzo, el pincel, el instrumento musical, etc. Sin embargo creemos que debemos aspirar a relaciones más ambiciosas entre los ordenadores y la creatividad. En lugar de verlos solamente como herramientas de ayuda a la creación, los ordenadores podrían ser considerados agentes creativos. Este punto de vista ha dado lugar a un nuevo subcampo de la Inteligencia Artificial denominado Creatividad Computacional. En este artículo abordamos la cuestión de la posibilidad de alcanzar dicha creatividad computacional mediante algunos ejemplos de programas de ordenador capaces de replicar algunos aspectos relacionados con el comportamiento creativo en los ámbitos de la música y la ciencia.

  6. Is the HP-UHP Hong'an-Dabie-Sulu orogen a piercing point for offset on the Tan-Lu fault?

    Science.gov (United States)

    Leech, Mary L.; Webb, Laura E.

    2013-02-01

    The Tan-Lu fault is a major strike-slip fault in eastern China that appears to offset the high-grade rocks of the Hong'an-Dabie-Sulu orogen left-laterally ˜540 km. We evaluate models for the collision between the South and North China blocks, published radiometric dates recording HP-UHP metamorphism and exhumation in the Hong'an-Dabie and Sulu terranes, and the timing of sinistral motion on the Tan-Lu fault to evaluate whether UHP rocks provide a piercing point for offset on the Tan-Lu fault. UHP metamorphism in Hong'an-Dabie was concurrent with Sulu based on U-Pb dating of coesite-bearing domains of zircon at 244 ± 5-226 ± 2 Ma for Hong'an-Dabie and 243 ± 4-225 ± 2 Ma for Sulu. Retrograde metamorphism began c. 220 Ma for both Hong'an-Dabie and Sulu, but retrograde zircon growth ended c. 214 Ma in Hong'an-Dabie and continued until c. 202 Ma in Sulu based on U-Pb dating of zircon domains external to coesite-bearing domains. Structures in Sulu are rotated 25° counter-clockwise from, but are broadly similar to, Hong'an-Dabie suggesting the two areas have a common Triassic orogenic history that pre-dates motion on the Tan-Lu fault, and that is consistent with paleomagnetic studies. We constructed a pre-Cretaceous restoration of the Hong'an-Dabie-Sulu belt that moves the Sulu terrane south, aligning the suture and the eclogite-facies isograd, and rotates Sulu c. 25° clockwise to re-align structures with Hong'an-Dabie. Our restoration is supported by published data and shows that the Hong'an-Dabie-Sulu orogen is a piercing point for post-collisional offset on the Tan-Lu fault and that these regions shared a common subduction-exhumation history. The Tan-Lu fault did not play a significant role in the Hong'an-Dabie-Sulu collision and likely developed later, in the Early Cretaceous.

  7. HP-Lattice QSAR for dynein proteins: experimental proteomics (2D-electrophoresis, mass spectrometry) and theoretic study of a Leishmania infantum sequence.

    Science.gov (United States)

    Dea-Ayuela, María Auxiliadora; Pérez-Castillo, Yunierkis; Meneses-Marcel, Alfredo; Ubeira, Florencio M; Bolas-Fernández, Francisco; Chou, Kuo-Chen; González-Díaz, Humberto

    2008-08-15

    The toxicity and inefficacy of actual organic drugs against Leishmaniosis justify research projects to find new molecular targets in Leishmania species including Leishmania infantum (L. infantum) and Leishmaniamajor (L. major), both important pathogens. In this sense, quantitative structure-activity relationship (QSAR) methods, which are very useful in Bioorganic and Medicinal Chemistry to discover small-sized drugs, may help to identify not only new drugs but also new drug targets, if we apply them to proteins. Dyneins are important proteins of these parasites governing fundamental processes such as cilia and flagella motion, nuclear migration, organization of the mitotic splinde, and chromosome separation during mitosis. However, despite the interest for them as potential drug targets, so far there has been no report whatsoever on dyneins with QSAR techniques. To the best of our knowledge, we report here the first QSAR for dynein proteins. We used as input the Spectral Moments of a Markov matrix associated to the HP-Lattice Network of the protein sequence. The data contain 411 protein sequences of different species selected by ClustalX to develop a QSAR that correctly discriminates on average between 92.75% and 92.51% of dyneins and other proteins in four different train and cross-validation datasets. We also report a combined experimental and theoretic study of a new dynein sequence in order to illustrate the utility of the model to search for potential drug targets with a practical example. First, we carried out a 2D-electrophoresis analysis of L. infantum biological samples. Next, we excised from 2D-E gels one spot of interest belonging to an unknown protein or protein fragment in the region Mdata base with the highest similarity score to the MS of the protein isolated from L. infantum. We used the QSAR model to predict the new sequence as dynein with probability of 99.99% without relying upon alignment. In order to confirm the previous function annotation we

  8. Thermodynamic studies at the low-dimensional spin systems HP-(VO)2P2O7, SrCu2(BO3)2, and azurite

    International Nuclear Information System (INIS)

    Bruehl, Andreas

    2007-01-01

    The present thesis deals with the low-temperature properties of three low-dimensional spin systems. The main experimental topic lies on measurements on the thermal expansion and on the specific heat, which were performed with a high-resolution capacitative dilatometer respectively an AC calorimeter facility. Because the so-called magnetic Grueneisen parameters, which describe the strength of the coupling of the magnetic partial system to the lattice, are throughout very large, especially the thermal-expansion measurements yield valuable information on the understanding of the treated systems. The central result of this thesis represent measurements on the high-pressure phase of (VO) 2 P 2 O 7 , briefly PP-VOPO. This system consists of alternating spin chains, whereby both exchange constants have similar values, i. e. only a weak alternation is present. In the thermal expansion an anomaly especially pronounced in chain direction at about 13 K. From the Grueneisen parameters determined by application of this model it can be concluded that the pronounced low-temperature anomaly in HP-VOPO is partly caused by the strong deformation dependence of the smaller of the two exchange constants, but partly also on the neighbourhood to a quantum critical point. The two-dimensional dimer system SrCu 2 (BO 3 ) 2 has gotten fame by the localization of the triplet excitations and the magnetization plateaus at certain fractions of the saturation magnetization conditioned by this. In the thermal expansion a distinct anomaly at the same temperature (T=8 K) is observed, as it also occurs in the specific heat. Finally measurements at the natural mineral azurite are presented, in which the spin are arranged in so-called diamond chains. In the magnetic susceptibility, the specific heat, and the thermal expansion a remarkable double structure occurs. Also the Λ-shaped antiferromagnetic order transition was studied and the phase diagram, consisting of paramagnetic, antiferromagnetic, and

  9. Quantum computing

    International Nuclear Information System (INIS)

    Steane, Andrew

    1998-01-01

    The subject of quantum computing brings together ideas from classical information theory, computer science, and quantum physics. This review aims to summarize not just quantum computing, but the whole subject of quantum information theory. Information can be identified as the most general thing which must propagate from a cause to an effect. It therefore has a fundamentally important role in the science of physics. However, the mathematical treatment of information, especially information processing, is quite recent, dating from the mid-20th century. This has meant that the full significance of information as a basic concept in physics is only now being discovered. This is especially true in quantum mechanics. The theory of quantum information and computing puts this significance on a firm footing, and has led to some profound and exciting new insights into the natural world. Among these are the use of quantum states to permit the secure transmission of classical information (quantum cryptography), the use of quantum entanglement to permit reliable transmission of quantum states (teleportation), the possibility of preserving quantum coherence in the presence of irreversible noise processes (quantum error correction), and the use of controlled quantum evolution for efficient computation (quantum computation). The common theme of all these insights is the use of quantum entanglement as a computational resource. It turns out that information theory and quantum mechanics fit together very well. In order to explain their relationship, this review begins with an introduction to classical information theory and computer science, including Shannon's theorem, error correcting codes, Turing machines and computational complexity. The principles of quantum mechanics are then outlined, and the Einstein, Podolsky and Rosen (EPR) experiment described. The EPR-Bell correlations, and quantum entanglement in general, form the essential new ingredient which distinguishes quantum from

  10. Quantum computing

    Energy Technology Data Exchange (ETDEWEB)

    Steane, Andrew [Department of Atomic and Laser Physics, University of Oxford, Clarendon Laboratory, Oxford (United Kingdom)

    1998-02-01

    The subject of quantum computing brings together ideas from classical information theory, computer science, and quantum physics. This review aims to summarize not just quantum computing, but the whole subject of quantum information theory. Information can be identified as the most general thing which must propagate from a cause to an effect. It therefore has a fundamentally important role in the science of physics. However, the mathematical treatment of information, especially information processing, is quite recent, dating from the mid-20th century. This has meant that the full significance of information as a basic concept in physics is only now being discovered. This is especially true in quantum mechanics. The theory of quantum information and computing puts this significance on a firm footing, and has led to some profound and exciting new insights into the natural world. Among these are the use of quantum states to permit the secure transmission of classical information (quantum cryptography), the use of quantum entanglement to permit reliable transmission of quantum states (teleportation), the possibility of preserving quantum coherence in the presence of irreversible noise processes (quantum error correction), and the use of controlled quantum evolution for efficient computation (quantum computation). The common theme of all these insights is the use of quantum entanglement as a computational resource. It turns out that information theory and quantum mechanics fit together very well. In order to explain their relationship, this review begins with an introduction to classical information theory and computer science, including Shannon's theorem, error correcting codes, Turing machines and computational complexity. The principles of quantum mechanics are then outlined, and the Einstein, Podolsky and Rosen (EPR) experiment described. The EPR-Bell correlations, and quantum entanglement in general, form the essential new ingredient which distinguishes quantum from

  11. Multiparty Computations

    DEFF Research Database (Denmark)

    Dziembowski, Stefan

    here and discuss other problems caused by the adaptiveness. All protocols in the thesis are formally specified and the proofs of their security are given. [1]Ronald Cramer, Ivan Damgård, Stefan Dziembowski, Martin Hirt, and Tal Rabin. Efficient multiparty computations with dishonest minority......In this thesis we study a problem of doing Verifiable Secret Sharing (VSS) and Multiparty Computations in a model where private channels between the players and a broadcast channel is available. The adversary is active, adaptive and has an unbounded computing power. The thesis is based on two...... to a polynomial time black-box reduction, the complexity of adaptively secure VSS is the same as that of ordinary secret sharing (SS), where security is only required against a passive, static adversary. Previously, such a connection was only known for linear secret sharing and VSS schemes. We then show...

  12. Scientific computing

    CERN Document Server

    Trangenstein, John A

    2017-01-01

    This is the third of three volumes providing a comprehensive presentation of the fundamentals of scientific computing. This volume discusses topics that depend more on calculus than linear algebra, in order to prepare the reader for solving differential equations. This book and its companions show how to determine the quality of computational results, and how to measure the relative efficiency of competing methods. Readers learn how to determine the maximum attainable accuracy of algorithms, and how to select the best method for computing problems. This book also discusses programming in several languages, including C++, Fortran and MATLAB. There are 90 examples, 200 exercises, 36 algorithms, 40 interactive JavaScript programs, 91 references to software programs and 1 case study. Topics are introduced with goals, literature references and links to public software. There are descriptions of the current algorithms in GSLIB and MATLAB. This book could be used for a second course in numerical methods, for either ...

  13. Computational Psychiatry

    Science.gov (United States)

    Wang, Xiao-Jing; Krystal, John H.

    2014-01-01

    Psychiatric disorders such as autism and schizophrenia arise from abnormalities in brain systems that underlie cognitive, emotional and social functions. The brain is enormously complex and its abundant feedback loops on multiple scales preclude intuitive explication of circuit functions. In close interplay with experiments, theory and computational modeling are essential for understanding how, precisely, neural circuits generate flexible behaviors and their impairments give rise to psychiatric symptoms. This Perspective highlights recent progress in applying computational neuroscience to the study of mental disorders. We outline basic approaches, including identification of core deficits that cut across disease categories, biologically-realistic modeling bridging cellular and synaptic mechanisms with behavior, model-aided diagnosis. The need for new research strategies in psychiatry is urgent. Computational psychiatry potentially provides powerful tools for elucidating pathophysiology that may inform both diagnosis and treatment. To achieve this promise will require investment in cross-disciplinary training and research in this nascent field. PMID:25442941

  14. Squabbling for a place on the Grid; Ian S Bruce reports on the fight to control the newest form of computing

    CERN Multimedia

    Bruce, I S

    2003-01-01

    "Grid computing, which aims to reduce business costs and reliance upon large-scale data centres by linking the processing power of many smaller machines, has been pushed to the front of the IT agenda... The concept has been embraced wholeheartedly by major high-tech players including Oracle, HP and Dell, who are now furiously jostling for position in the race to become the emerging new field's undisputed leaders" (1 page).

  15. Computational artifacts

    DEFF Research Database (Denmark)

    Schmidt, Kjeld; Bansler, Jørgen P.

    2016-01-01

    The key concern of CSCW research is that of understanding computing technologies in the social context of their use, that is, as integral features of our practices and our lives, and to think of their design and implementation under that perspective. However, the question of the nature...... of that which is actually integrated in our practices is often discussed in confusing ways, if at all. The article aims to try to clarify the issue and in doing so revisits and reconsiders the notion of ‘computational artifact’....

  16. Computer security

    CERN Document Server

    Gollmann, Dieter

    2011-01-01

    A completely up-to-date resource on computer security Assuming no previous experience in the field of computer security, this must-have book walks you through the many essential aspects of this vast topic, from the newest advances in software and technology to the most recent information on Web applications security. This new edition includes sections on Windows NT, CORBA, and Java and discusses cross-site scripting and JavaScript hacking as well as SQL injection. Serving as a helpful introduction, this self-study guide is a wonderful starting point for examining the variety of competing sec

  17. Cloud Computing

    CERN Document Server

    Antonopoulos, Nick

    2010-01-01

    Cloud computing has recently emerged as a subject of substantial industrial and academic interest, though its meaning and scope is hotly debated. For some researchers, clouds are a natural evolution towards the full commercialisation of grid systems, while others dismiss the term as a mere re-branding of existing pay-per-use technologies. From either perspective, 'cloud' is now the label of choice for accountable pay-per-use access to third party applications and computational resources on a massive scale. Clouds support patterns of less predictable resource use for applications and services a

  18. Computational Logistics

    DEFF Research Database (Denmark)

    Pacino, Dario; Voss, Stefan; Jensen, Rune Møller

    2013-01-01

    This book constitutes the refereed proceedings of the 4th International Conference on Computational Logistics, ICCL 2013, held in Copenhagen, Denmark, in September 2013. The 19 papers presented in this volume were carefully reviewed and selected for inclusion in the book. They are organized in to...... in topical sections named: maritime shipping, road transport, vehicle routing problems, aviation applications, and logistics and supply chain management.......This book constitutes the refereed proceedings of the 4th International Conference on Computational Logistics, ICCL 2013, held in Copenhagen, Denmark, in September 2013. The 19 papers presented in this volume were carefully reviewed and selected for inclusion in the book. They are organized...

  19. Computational Logistics

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the 4th International Conference on Computational Logistics, ICCL 2013, held in Copenhagen, Denmark, in September 2013. The 19 papers presented in this volume were carefully reviewed and selected for inclusion in the book. They are organized in to...... in topical sections named: maritime shipping, road transport, vehicle routing problems, aviation applications, and logistics and supply chain management.......This book constitutes the refereed proceedings of the 4th International Conference on Computational Logistics, ICCL 2013, held in Copenhagen, Denmark, in September 2013. The 19 papers presented in this volume were carefully reviewed and selected for inclusion in the book. They are organized...

  20. Computational engineering

    CERN Document Server

    2014-01-01

    The book presents state-of-the-art works in computational engineering. Focus is on mathematical modeling, numerical simulation, experimental validation and visualization in engineering sciences. In particular, the following topics are presented: constitutive models and their implementation into finite element codes, numerical models in nonlinear elasto-dynamics including seismic excitations, multiphase models in structural engineering and multiscale models of materials systems, sensitivity and reliability analysis of engineering structures, the application of scientific computing in urban water management and hydraulic engineering, and the application of genetic algorithms for the registration of laser scanner point clouds.

  1. Computer busses

    CERN Document Server

    Buchanan, William

    2000-01-01

    As more and more equipment is interface or'bus' driven, either by the use of controllers or directly from PCs, the question of which bus to use is becoming increasingly important both in industry and in the office. 'Computer Busses' has been designed to help choose the best type of bus for the particular application.There are several books which cover individual busses, but none which provide a complete guide to computer busses. The author provides a basic theory of busses and draws examples and applications from real bus case studies. Busses are analysed using from a top-down approach, helpin

  2. Reconfigurable Computing

    CERN Document Server

    Cardoso, Joao MP

    2011-01-01

    As the complexity of modern embedded systems increases, it becomes less practical to design monolithic processing platforms. As a result, reconfigurable computing is being adopted widely for more flexible design. Reconfigurable Computers offer the spatial parallelism and fine-grained customizability of application-specific circuits with the postfabrication programmability of software. To make the most of this unique combination of performance and flexibility, designers need to be aware of both hardware and software issues. FPGA users must think not only about the gates needed to perform a comp

  3. Energy Efficiency in Computing (2/2)

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    We will start the second day of our energy efficient computing series with a brief discussion of software and the impact it has on energy consumption. A second major point of this lecture will be the current state of research and a few future technologies, ranging from mainstream (e.g. the Internet of Things) to exotic. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP and Google), as well as international research institutes, such as EPFL. Currently, Andrzej acts as a consultant on technology and innovation with TIK Services (http://tik.services), and runs a peer-to-peer lending start-up. NB! All Academic Lectures are recorded. No webcast! Because of a problem of the recording equipment, this lecture will be repeated for recording pu...

  4. Riemannian computing in computer vision

    CERN Document Server

    Srivastava, Anuj

    2016-01-01

    This book presents a comprehensive treatise on Riemannian geometric computations and related statistical inferences in several computer vision problems. This edited volume includes chapter contributions from leading figures in the field of computer vision who are applying Riemannian geometric approaches in problems such as face recognition, activity recognition, object detection, biomedical image analysis, and structure-from-motion. Some of the mathematical entities that necessitate a geometric analysis include rotation matrices (e.g. in modeling camera motion), stick figures (e.g. for activity recognition), subspace comparisons (e.g. in face recognition), symmetric positive-definite matrices (e.g. in diffusion tensor imaging), and function-spaces (e.g. in studying shapes of closed contours).   ·         Illustrates Riemannian computing theory on applications in computer vision, machine learning, and robotics ·         Emphasis on algorithmic advances that will allow re-application in other...

  5. Statistical Computing

    Indian Academy of Sciences (India)

    inference and finite population sampling. Sudhakar Kunte. Elements of statistical computing are discussed in this series. ... which captain gets an option to decide whether to field first or bat first ... may of course not be fair, in the sense that the team which wins ... describe two methods of drawing a random number between 0.

  6. Computational biology

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2011-01-01

    Computation via biological devices has been the subject of close scrutiny since von Neumann’s early work some 60 years ago. In spite of the many relevant works in this field, the notion of programming biological devices seems to be, at best, ill-defined. While many devices are claimed or proved t...

  7. Computing News

    CERN Multimedia

    McCubbin, N

    2001-01-01

    We are still five years from the first LHC data, so we have plenty of time to get the computing into shape, don't we? Well, yes and no: there is time, but there's an awful lot to do! The recently-completed CERN Review of LHC Computing gives the flavour of the LHC computing challenge. The hardware scale for each of the LHC experiments is millions of 'SpecInt95' (SI95) units of cpu power and tens of PetaBytes of data storage. PCs today are about 20-30SI95, and expected to be about 100 SI95 by 2005, so it's a lot of PCs. This hardware will be distributed across several 'Regional Centres' of various sizes, connected by high-speed networks. How to realise this in an orderly and timely fashion is now being discussed in earnest by CERN, Funding Agencies, and the LHC experiments. Mixed in with this is, of course, the GRID concept...but that's a topic for another day! Of course hardware, networks and the GRID constitute just one part of the computing. Most of the ATLAS effort is spent on software development. What we ...

  8. Quantum Computation

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 9. Quantum Computation - Particle and Wave Aspects of Algorithms. Apoorva Patel. General Article Volume 16 Issue 9 September 2011 pp 821-835. Fulltext. Click here to view fulltext PDF. Permanent link:

  9. Cloud computing.

    Science.gov (United States)

    Wink, Diane M

    2012-01-01

    In this bimonthly series, the author examines how nurse educators can use Internet and Web-based technologies such as search, communication, and collaborative writing tools; social networking and social bookmarking sites; virtual worlds; and Web-based teaching and learning programs. This article describes how cloud computing can be used in nursing education.

  10. Computer Recreations.

    Science.gov (United States)

    Dewdney, A. K.

    1988-01-01

    Describes the creation of the computer program "BOUNCE," designed to simulate a weighted piston coming into equilibrium with a cloud of bouncing balls. The model follows the ideal gas law. Utilizes the critical event technique to create the model. Discusses another program, "BOOM," which simulates a chain reaction. (CW)

  11. [Grid computing

    CERN Multimedia

    Wolinsky, H

    2003-01-01

    "Turn on a water spigot, and it's like tapping a bottomless barrel of water. Ditto for electricity: Flip the switch, and the supply is endless. But computing is another matter. Even with the Internet revolution enabling us to connect in new ways, we are still limited to self-contained systems running locally stored software, limited by corporate, institutional and geographic boundaries" (1 page).

  12. Computational Finance

    DEFF Research Database (Denmark)

    Rasmussen, Lykke

    One of the major challenges in todays post-crisis finance environment is calculating the sensitivities of complex products for hedging and risk management. Historically, these derivatives have been determined using bump-and-revalue, but due to the increasing magnitude of these computations does...

  13. Optical Computing

    Indian Academy of Sciences (India)

    Optical computing technology is, in general, developing in two directions. One approach is ... current support in many places, with private companies as well as governments in several countries encouraging such research work. For example, much ... which enables more information to be carried and data to be processed.

  14. Computable Frames in Computable Banach Spaces

    Directory of Open Access Journals (Sweden)

    S.K. Kaushik

    2016-06-01

    Full Text Available We develop some parts of the frame theory in Banach spaces from the point of view of Computable Analysis. We define computable M-basis and use it to construct a computable Banach space of scalar valued sequences. Computable Xd frames and computable Banach frames are also defined and computable versions of sufficient conditions for their existence are obtained.

  15. Parallel computation of electrostatic potentials and fields in technical geometries on SUPRENUM

    International Nuclear Information System (INIS)

    Alef, M.

    1990-02-01

    The programs EPOTZR und EFLDZR have been developed in order to compute electrostatic potentials and the corresponding fields in technical geometries (example: Diode geometry for optimum focussing of ion beams in pulsed high-current ion diodes). The Poisson equation is discretized in a two-dimensional boundary-fitted grid in the (r,z)-plane and solved using multigrid methods. The z- and r-components of the field are determined by numerical differentiation of the potential. This report contains the user's guide of the SUPRENUM versions EPOTZR-P and EFLDZR-P. (orig./HP) [de

  16. Computational methods for fracture analysis of heavy-section steel technology (HSST) pressure vessel experiments

    International Nuclear Information System (INIS)

    Bass, B.R.; Bryan, R.H.; Bryson, J.W.; Merkle, J.G.

    1985-01-01

    This paper summarizes the capabilities and applications of the general-purpose and special-purpose computer programs that have been developed at ORNL for use in fracture mechanics analyses of HSST pressure vessel experiments. Emphasis is placed on the OCA/USA code, which is designed for analysis of pressurized-thermal-shock (PTS) conditions, and on the ORMGEN/ADINA/ORVIRT system which is used for more general analysis. Fundamental features of these programs are discussed, along wih applications to pressure vessel experiments. (orig./HP)

  17. Algebraic computing

    International Nuclear Information System (INIS)

    MacCallum, M.A.H.

    1990-01-01

    The implementation of a new computer algebra system is time consuming: designers of general purpose algebra systems usually say it takes about 50 man-years to create a mature and fully functional system. Hence the range of available systems and their capabilities changes little between one general relativity meeting and the next, despite which there have been significant changes in the period since the last report. The introductory remarks aim to give a brief survey of capabilities of the principal available systems and highlight one or two trends. The reference to the most recent full survey of computer algebra in relativity and brief descriptions of the Maple, REDUCE and SHEEP and other applications are given. (author)

  18. Greenschist-Facies Pseudotachylytes and Gouge: a Microstructural Study of the Deformation Propagation at the Boundary Between Hp-Metabasite and Calcite Bearing Metasediments

    Science.gov (United States)

    Crispini, L.; Scambelluri, M.; Capponi, G.

    2013-12-01

    Recent friction experiments on calcite-bearing systems reproduce pseudotachylyte structures, that are diagnostic of dinamic calcite recrystallization related to seismic slip in the shallow crust. Here we provide the study of a pseudotachylyte (PT) bearing low angle oblique-slip fault. The fault is linked to the exhumation of Alpine HP-ophiolites and it is syn- to post-metamorphic with respect to retrograde greenschist facies metamorphism. The observed microstructures developed at the brittle-ductile transition and suggest that seismic and interseismic slip was enhanced by interaction with fluids. The fault zone is in-between high-pressure eclogite-facies metabasites (hangingwall) and calcite bearing metasediments (footwall). The mafic rocks largely consist of upper greenschist facies hornblende, albite, chlorite, epidote with relict eclogitic garnet, Na-pyroxene and rutile; metasediments correspond to calcschist and micaschist with quartz, phengite, zoisite, chlorite, calcite and relics of garnet. Key features of the oucrop are: the thickness and geometry of the PT and gouge; the multiple production of PT characterized by overprinting plastic and brittle deformation; the occurrence in footwall metasediments of mm-thick bands of finely recrystallized calcite coeval with PT development in the hangingwall. The damage zone is ca. 2 m-thick and is characterized by two black, ultra-finegrained straight and sharp Principal Slip Zones (PSZ) marked by PT. The damage zone shows a variety of fault rocks (cataclasite and ultracataclasite, gouge and PT) with multiple crosscutting relationships. Within the two main PSZ, PT occurs in 10-20 cm thick layer, in small scale injection veins and in microfractures. In the mafic hanging wall, the PT is recrystallized and does not preserve glass: it shows flow structures with subrounded, embayed and rebsorbed quartz in a fine grained matrix composed of isotropic albite + chlorite + quartz + epidote + titanite, suggesting recrystallization

  19. Computational Controversy

    OpenAIRE

    Timmermans, Benjamin; Kuhn, Tobias; Beelen, Kaspar; Aroyo, Lora

    2017-01-01

    Climate change, vaccination, abortion, Trump: Many topics are surrounded by fierce controversies. The nature of such heated debates and their elements have been studied extensively in the social science literature. More recently, various computational approaches to controversy analysis have appeared, using new data sources such as Wikipedia, which help us now better understand these phenomena. However, compared to what social sciences have discovered about such debates, the existing computati...

  20. Computed tomography

    International Nuclear Information System (INIS)

    Andre, M.; Resnick, D.

    1988-01-01

    Computed tomography (CT) has matured into a reliable and prominent tool for study of the muscoloskeletal system. When it was introduced in 1973, it was unique in many ways and posed a challenge to interpretation. It is in these unique features, however, that its advantages lie in comparison with conventional techniques. These advantages will be described in a spectrum of important applications in orthopedics and rheumatology

  1. Computed radiography

    International Nuclear Information System (INIS)

    Pupchek, G.

    2004-01-01

    Computed radiography (CR) is an image acquisition process that is used to create digital, 2-dimensional radiographs. CR employs a photostimulable phosphor-based imaging plate, replacing the standard x-ray film and intensifying screen combination. Conventional radiographic exposure equipment is used with no modification required to the existing system. CR can transform an analog x-ray department into a digital one and eliminates the need for chemicals, water, darkrooms and film processor headaches. (author)

  2. Computational universes

    International Nuclear Information System (INIS)

    Svozil, Karl

    2005-01-01

    Suspicions that the world might be some sort of a machine or algorithm existing 'in the mind' of some symbolic number cruncher have lingered from antiquity. Although popular at times, the most radical forms of this idea never reached mainstream. Modern developments in physics and computer science have lent support to the thesis, but empirical evidence is needed before it can begin to replace our contemporary world view

  3. Effect of composition, heat treatment and processing technologies on the microstructure and properties of HP and IP rotors of large steam turbines from 1CrMoV steels

    Energy Technology Data Exchange (ETDEWEB)

    Tchizhik, A.A. [The Polzunov Central Boiler and Turbine Institute, Department the Fatigue Life of Materials for Power Plant Equipment, St. Petersburg (Russian Federation)

    1998-12-31

    In the presentation the evolution of the technology manufacturing of the large forging from the 1CrMoV steels and the results complex of the long time investigations rotors on virgin state and after different operation times is analyzed. Among the information there are the criterion of the optimization of the composition steel service properties, especially super long - term creep resistance, creep fracture and long time cracks resistance. Two safety coefficients: stress (SSC) and time safety coefficient (TSC) must be used for calculations of the possibility prolongation service life of HP and IP rotors for large steam turbines. (orig.) 11 refs.

  4. Effect of composition, heat treatment and processing technologies on the microstructure and properties of HP and IP rotors of large steam turbines from 1CrMoV steels

    Energy Technology Data Exchange (ETDEWEB)

    Tchizhik, A A [The Polzunov Central Boiler and Turbine Institute, Department the Fatigue Life of Materials for Power Plant Equipment, St. Petersburg (Russian Federation)

    1999-12-31

    In the presentation the evolution of the technology manufacturing of the large forging from the 1CrMoV steels and the results complex of the long time investigations rotors on virgin state and after different operation times is analyzed. Among the information there are the criterion of the optimization of the composition steel service properties, especially super long - term creep resistance, creep fracture and long time cracks resistance. Two safety coefficients: stress (SSC) and time safety coefficient (TSC) must be used for calculations of the possibility prolongation service life of HP and IP rotors for large steam turbines. (orig.) 11 refs.

  5. Hot Chips and Hot Interconnects for High End Computing Systems

    Science.gov (United States)

    Saini, Subhash

    2005-01-01

    I will discuss several processors: 1. The Cray proprietary processor used in the Cray X1; 2. The IBM Power 3 and Power 4 used in an IBM SP 3 and IBM SP 4 systems; 3. The Intel Itanium and Xeon, used in the SGI Altix systems and clusters respectively; 4. IBM System-on-a-Chip used in IBM BlueGene/L; 5. HP Alpha EV68 processor used in DOE ASCI Q cluster; 6. SPARC64 V processor, which is used in the Fujitsu PRIMEPOWER HPC2500; 7. An NEC proprietary processor, which is used in NEC SX-6/7; 8. Power 4+ processor, which is used in Hitachi SR11000; 9. NEC proprietary processor, which is used in Earth Simulator. The IBM POWER5 and Red Storm Computing Systems will also be discussed. The architectures of these processors will first be presented, followed by interconnection networks and a description of high-end computer systems based on these processors and networks. The performance of various hardware/programming model combinations will then be compared, based on latest NAS Parallel Benchmark results (MPI, OpenMP/HPF and hybrid (MPI + OpenMP). The tutorial will conclude with a discussion of general trends in the field of high performance computing, (quantum computing, DNA computing, cellular engineering, and neural networks).

  6. Emission computer tomography on a Dodewaard mixed oxide fuel pin

    International Nuclear Information System (INIS)

    Buurveld, H.A.; Dassel, G.

    1993-12-01

    A nondestructive technique as well as a destructive PIE technique have been used to verify the results obtained with a newly 8-e computer tomography (GECT) system. Multi isotope Scanning (MIS), electron probe micro analysis (EPMA) and GECT were used on a mixed oxide (MOX) fuel rod from the Dodewaard reactor with an average burnup of 24 MWd/kg fuel. GECT shows migration of Cs to the periphery of fuel pellets and to radial cracks and pores in the fuel, whereas MIS shows Cs migration to pellet interfaces. The EPMA technique appeared not to be useful to show migration of Cs but, it shows the distribution of fission products from Pu. EPMA clearly shows the distribution of fission products from Pu, but did not reveal the Cs-migration. (orig./HP)

  7. Automatization of physical experiments on-line with the MINSK-32 computer

    International Nuclear Information System (INIS)

    Fefilov, B.V.; Mikhushkin, A.V.; Morozov, V.M.; Sukhov, A.M.; Chelnokov, L.P.

    1978-01-01

    The system for data acquisition and processing of complex multi-dimensional experiments is described. The system includes the autonomous modules in the CAMAC standard, the NAIRI-4 small computer and the MINSK-32 base computer. The NAIRI-4 computer effects preliminary storage, data processing and experiment control. Its software includes the microprogram software of the NAIRI-4 computer, the software of the NAIRI-2 computer, the software of the PDP-11 computer, the technological software on the Es computers. A crate controller and a display driver are connected to the main channel for the operation of the NAIRI-4 computer on line with experimental devices. An input-output channel commutator, which transforms the MINSK-32 computer levels to the TTL levels and vice versa, was developed to enlarge the possibilities of the connection of the measurement modules to the MINSK-32 computer. The graphic display on the basis of the HP-1300A monitor with a light pencil is used for highly effective spectrum processing

  8. Customizable computing

    CERN Document Server

    Chen, Yu-Ting; Gill, Michael; Reinman, Glenn; Xiao, Bingjun

    2015-01-01

    Since the end of Dennard scaling in the early 2000s, improving the energy efficiency of computation has been the main concern of the research community and industry. The large energy efficiency gap between general-purpose processors and application-specific integrated circuits (ASICs) motivates the exploration of customizable architectures, where one can adapt the architecture to the workload. In this Synthesis lecture, we present an overview and introduction of the recent developments on energy-efficient customizable architectures, including customizable cores and accelerators, on-chip memory

  9. Computed tomography

    International Nuclear Information System (INIS)

    Wells, P.; Davis, J.; Morgan, M.

    1994-01-01

    X-ray or gamma-ray transmission computed tomography (CT) is a powerful non-destructive evaluation (NDE) technique that produces two-dimensional cross-sectional images of an object without the need to physically section it. CT is also known by the acronym CAT, for computerised axial tomography. This review article presents a brief historical perspective on CT, its current status and the underlying physics. The mathematical fundamentals of computed tomography are developed for the simplest transmission CT modality. A description of CT scanner instrumentation is provided with an emphasis on radiation sources and systems. Examples of CT images are shown indicating the range of materials that can be scanned and the spatial and contrast resolutions that may be achieved. Attention is also given to the occurrence, interpretation and minimisation of various image artefacts that may arise. A final brief section is devoted to the principles and potential of a range of more recently developed tomographic modalities including diffraction CT, positron emission CT and seismic tomography. 57 refs., 2 tabs., 14 figs

  10. Study on 'Safety qualification of process computers used in safety systems of nuclear power plants'

    International Nuclear Information System (INIS)

    Bertsche, K.; Hoermann, E.

    1991-01-01

    The study aims at developing safety standards for hardware and software of computer systems which are increasingly used also for important safety systems in nuclear power plants. The survey of the present state-of-the-art of safety requirements and specifications for safety-relevant systems and, additionally, for process computer systems has been compiled from national and foreign rules. In the Federal Republic of Germany the KTA safety guides and the BMI/BMU safety criteria have to be observed. For the design of future computer-aided systems in nuclear power plants it will be necessary to apply the guidelines in [DIN-880] and [DKE-714] together with [DIN-192]. With the aid of a risk graph the various functions of a system, or of a subsystem, can be evaluated with regard to their significance for safety engineering. (orig./HP) [de

  11. Computing Services and Assured Computing

    Science.gov (United States)

    2006-05-01

    fighters’ ability to execute the mission.” Computing Services 4 We run IT Systems that: provide medical care pay the warfighters manage maintenance...users • 1,400 applications • 18 facilities • 180 software vendors • 18,000+ copies of executive software products • Virtually every type of mainframe and... chocs electriques, de branchez les deux cordons d’al imentation avant de faire le depannage P R IM A R Y SD A S B 1 2 PowerHub 7000 RST U L 00- 00

  12. Computational neuroscience

    CERN Document Server

    Blackwell, Kim L

    2014-01-01

    Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases. Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesiv...

  13. computer networks

    Directory of Open Access Journals (Sweden)

    N. U. Ahmed

    2002-01-01

    Full Text Available In this paper, we construct a new dynamic model for the Token Bucket (TB algorithm used in computer networks and use systems approach for its analysis. This model is then augmented by adding a dynamic model for a multiplexor at an access node where the TB exercises a policing function. In the model, traffic policing, multiplexing and network utilization are formally defined. Based on the model, we study such issues as (quality of service QoS, traffic sizing and network dimensioning. Also we propose an algorithm using feedback control to improve QoS and network utilization. Applying MPEG video traces as the input traffic to the model, we verify the usefulness and effectiveness of our model.

  14. Computer Tree

    Directory of Open Access Journals (Sweden)

    Onur AĞAOĞLU

    2014-12-01

    Full Text Available It is crucial that gifted and talented students should be supported by different educational methods for their interests and skills. The science and arts centres (gifted centres provide the Supportive Education Program for these students with an interdisciplinary perspective. In line with the program, an ICT lesson entitled “Computer Tree” serves for identifying learner readiness levels, and defining the basic conceptual framework. A language teacher also contributes to the process, since it caters for the creative function of the basic linguistic skills. The teaching technique is applied for 9-11 aged student level. The lesson introduces an evaluation process including basic information, skills, and interests of the target group. Furthermore, it includes an observation process by way of peer assessment. The lesson is considered to be a good sample of planning for any subject, for the unpredicted convergence of visual and technical abilities with linguistic abilities.

  15. Computed tomography

    International Nuclear Information System (INIS)

    Boyd, D.P.

    1989-01-01

    This paper reports on computed tomographic (CT) scanning which has improved computer-assisted imaging modalities for radiologic diagnosis. The advantage of this modality is its ability to image thin cross-sectional planes of the body, thus uncovering density information in three dimensions without tissue superposition problems. Because this enables vastly superior imaging of soft tissues in the brain and body, CT scanning was immediately successful and continues to grow in importance as improvements are made in speed, resolution, and cost efficiency. CT scanners are used for general purposes, and the more advanced machines are generally preferred in large hospitals, where volume and variety of usage justifies the cost. For imaging in the abdomen, a scanner with a rapid speed is preferred because peristalsis, involuntary motion of the diaphram, and even cardiac motion are present and can significantly degrade image quality. When contrast media is used in imaging to demonstrate scanner, immediate review of images, and multiformat hardcopy production. A second console is reserved for the radiologist to read images and perform the several types of image analysis that are available. Since CT images contain quantitative information in terms of density values and contours of organs, quantitation of volumes, areas, and masses is possible. This is accomplished with region-of- interest methods, which involve the electronic outlining of the selected region of the television display monitor with a trackball-controlled cursor. In addition, various image- processing options, such as edge enhancement (for viewing fine details of edges) or smoothing filters (for enhancing the detectability of low-contrast lesions) are useful tools

  16. Cloud Computing: The Future of Computing

    OpenAIRE

    Aggarwal, Kanika

    2013-01-01

    Cloud computing has recently emerged as a new paradigm for hosting and delivering services over the Internet. Cloud computing is attractive to business owners as it eliminates the requirement for users to plan ahead for provisioning, and allows enterprises to start from the small and increase resources only when there is a rise in service demand. The basic principles of cloud computing is to make the computing be assigned in a great number of distributed computers, rather then local computer ...

  17. Computer Program for Calculation of Complex Chemical Equilibrium Compositions, Rocket Performance, Incident and Reflected Shocks, and Chapman-Jouguet Detonations. Interim Revision, March 1976

    Science.gov (United States)

    Gordon, S.; Mcbride, B. J.

    1976-01-01

    A detailed description of the equations and computer program for computations involving chemical equilibria in complex systems is given. A free-energy minimization technique is used. The program permits calculations such as (1) chemical equilibrium for assigned thermodynamic states (T,P), (H,P), (S,P), (T,V), (U,V), or (S,V), (2) theoretical rocket performance for both equilibrium and frozen compositions during expansion, (3) incident and reflected shock properties, and (4) Chapman-Jouguet detonation properties. The program considers condensed species as well as gaseous species.

  18. Computer Refurbishment

    International Nuclear Information System (INIS)

    Ichiyen, Norman; Chan, Dominic; Thompson, Paul

    2004-01-01

    The major activity for the 18-month refurbishment outage at the Point Lepreau Generating Station is the replacement of all 380 fuel channel and calandria tube assemblies and the lower portion of connecting feeder pipes. New Brunswick Power would also take advantage of this outage to conduct a number of repairs, replacements, inspections and upgrades (such as rewinding or replacing the generator, replacement of shutdown system trip computers, replacement of certain valves and expansion joints, inspection of systems not normally accessible, etc.). This would allow for an additional 25 to 30 years. Among the systems to be replaced are the PDC's for both shutdown systems. Assessments have been completed for both the SDS1 and SDS2 PDC's, and it has been decided to replace the SDS2 PDCs with the same hardware and software approach that has been used successfully for the Wolsong 2, 3, and 4 and the Qinshan 1 and 2 SDS2 PDCs. For SDS1, it has been decided to use the same software development methodology that was used successfully for the Wolsong and Qinshan called the I A and to use a new hardware platform in order to ensure successful operation for the 25-30 year station operating life. The selected supplier is Triconex, which uses a triple modular redundant architecture that will enhance the robustness/fault tolerance of the design with respect to equipment failures

  19. Computation of fission product distribution in core and primary circuit of a high temperature reactor during normal operation

    International Nuclear Information System (INIS)

    Mattke, U.H.

    1991-08-01

    The fission product release during normal operation from the core of a high temperature reactor is well known to be very low. A HTR-Modul-reactor with a reduced power of 170 MW th is examined under the aspect whether the contamination with Cs-137 as most important nuclide will be so low that a helium turbine in the primary circuit is possible. The program SPTRAN is the tool for the computations and siumlations of fission product transport in HTRs. The program initially developed for computations of accident events has been enlarged for computing the fission product transport under the conditions of normal operation. The theoretical basis, the used programs and data basis are presented followed by the results of the computations. These results are explained and discussed; moreover the consequences and future possibilities of development are shown. (orig./HP) [de

  20. Computed Tomography (CT) -- Sinuses

    Medline Plus

    Full Text Available ... Physician Resources Professions Site Index A-Z Computed Tomography (CT) - Sinuses Computed tomography (CT) of the sinuses ... CT of the Sinuses? What is CT (Computed Tomography) of the Sinuses? Computed tomography, more commonly known ...