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Sample records for howard pat dale

  1. Dale Sayers Festschrift

    International Nuclear Information System (INIS)

    Stern, Edward A.

    2007-01-01

    This Festschrift is in honor of Dale Sayers who passed away in November 2004. Dale played a pivotal role in initiating the modern era of X-ray Absorption Fine Structure (XAFS) 35 years ago. The prehistory of XAFS before the modern era consisted of 40 years of confusion caused by Kronig's two different theories of the extended XAFS (EXAFS), the Short-Range Order (SRO) and Long-Range Order (LRO) theories. Dale's PhD thesis on EXAFS led to the idea of a Fourier transform to definitely prove that SRO is the correct theory and then to the development of XAFS as a structure determination technique

  2. Dale Coke: Coke Farm

    OpenAIRE

    Farmer, Ellen

    2010-01-01

    Dale Coke grew up on an apricot orchard in California’s Santa Clara Valley. In 1976 he bought ten acres of farmland near Watsonville in Santa Cruz County but continued to work repairing fuel injection systems rather than farming at his new home. In 1981, a struggle with cancer inspired him to rethink his life and become an organic farmer. His neighbor, who had grown strawberries using pesticides and chemical fertilizers, asserted that strawberries could not be grown organically. Coke set out ...

  3. Teacher's PAT?

    DEFF Research Database (Denmark)

    Vanhuysse, Pieter; Sulitzeanu-Kenan, Raanan

    2009-01-01

    This article aims to contribute to current theoretical debates about political power and agency relationships in education and other public sector settings. In a recent clarion call for a major redirection of political principal-agent theories (PAT), Terry Moe has argued that standard information...... asymmetries ought no longer to be regarded as the sole foundation of bureaucrat power. According to Moe, current theories largely overlook the direct electoral power of agents and their unions (EPA) in voting for their own bureaucratic principals. Therefore, they are biased systematically towards under...

  4. Anmeldelse : Howard Zehr: Genoprettende Ret

    DEFF Research Database (Denmark)

    Adrian, Lin

    2010-01-01

    Anmeldelse af Howard Zehr: Genoprettende ret, der udkom i 2008. Oversat fra engelsk: Restorative Justice Udgivelsesdato: august 2010......Anmeldelse af Howard Zehr: Genoprettende ret, der udkom i 2008. Oversat fra engelsk: Restorative Justice Udgivelsesdato: august 2010...

  5. Dale Sayers' Scientific Legacy in North Carolina

    International Nuclear Information System (INIS)

    Paesler, M. A.; Washington, J. S.

    2007-01-01

    From the time he joined the NC State faculty in 1976 until his untimely death in 2004, Dale Sayers enthusiastically offered the strengths of x-ray absorption spectroscopy to colleagues with a wide variety of interests. A master collaborator. Dale teamed with researchers from disciplines as far ranging as solid state physics, biochemistry, electrical engineering, medicine and geology. In this talk, offered as a tribute to these efforts, I will highlight a small subset of Dale's many collaborations with other North Carolina faculty. The few cited examples chosen from a host of collaborations reveal the strength of Dale's science and the breadth of his vision. I will also tell of Dale's efforts to build a synchrotron on our campus in an effort that nearly succeeded despite ill-timed political adversity and ultimately tragic obstacles

  6. Editorial: Howard Taylor Ricketts

    Directory of Open Access Journals (Sweden)

    Facultad de Medicina Revista

    1941-05-01

    Full Text Available Howard Taylor Ricketts nació en Findlay (Ohio el 9 de febrero de 1871. Pasó su niñez en Nebraska, recibió su título de bachiller en la Universidad de ese Estado, en 1894 y se graduó de médico en Northwestern University, en 1897. Hizo su internado en el Cook-County de Chicago. Practicó estdios especiales de dermatología en el Rush Medical College durante dos años. En 1900 contrajo matrimonio con Myra Tubbs, inteligente mujer que colaboró en sus trabajos con rara devoción, ardiente interés y constante estímulo.

  7. Implementing PAT with Standards

    Science.gov (United States)

    Chandramohan, Laakshmana Sabari; Doolla, Suryanarayana; Khaparde, S. A.

    2016-02-01

    Perform Achieve Trade (PAT) is a market-based incentive mechanism to promote energy efficiency. The purpose of this work is to address the challenges inherent to inconsistent representation of business processes, and interoperability issues in PAT like cap-and-trade mechanisms especially when scaled. Studies by various agencies have highlighted that as the mechanism evolves including more industrial sectors and industries in its ambit, implementation will become more challenging. This paper analyses the major needs of PAT (namely tracking, monitoring, auditing & verifying energy-saving reports, and providing technical support & guidance to stakeholders); and how the aforesaid reasons affect them. Though current technologies can handle these challenges to an extent, standardization activities for implementation have been scanty for PAT and this work attempts to evolve them. The inconsistent modification of business processes, rules, and procedures across stakeholders, and interoperability among heterogeneous systems are addressed. This paper proposes the adoption of specifically two standards into PAT, namely Business Process Model and Notation for maintaining consistency in business process modelling, and Common Information Model (IEC 61970, 61968, 62325 combined) for information exchange. Detailed architecture and organization of these adoptions are reported. The work can be used by PAT implementing agencies, stakeholders, and standardization bodies.

  8. Astronaut Dale Gardner rehearses during EVA practice

    Science.gov (United States)

    1984-01-01

    Astronaut Dale A. Gardner, 51-A mission specialist, rehearses control of manned maneuvering unit (MMU) during a practice for an extravehicular activity (EVA). Gardner is in the Shuttle mockup and integration laboratory at JSC. Gardner handles a stinger device to make initial contact with one of the two satellites they will be working with.

  9. PAT tools for fermentation processes

    DEFF Research Database (Denmark)

    Gernaey, Krist

    The publication of the Process Analytical Technology (PAT) guidance has been one of the most important milestones for pharmaceutical production during the past ten years. The ideas outlined in the PAT guidance are also applied in other industries, for example the fermentation industry. Process...... knowledge is central in PAT projects. This presentation therefore gives a brief overview of a number of PAT tools for collecting process knowledge on fermentation processes: - On-line sensors, where for example spectroscopic measurements are increasingly applied - Mechanistic models, which can be used...

  10. PAT tools for fermentation processes

    DEFF Research Database (Denmark)

    Gernaey, Krist; Bolic, Andrijana; Svanholm, Bent

    2012-01-01

    The publication of the Process Analytical Technology (PAT) guidance has been one of the most important milestones for pharmaceutical production during the past ten years. The ideas outlined in the PAT guidance are also applied in other industries, for example the fermentation industry. Process...... knowledge is central in PAT projects. This manuscript therefore gives a brief overview of a number of PAT tools for collecting process knowledge on fermentation processes: on-line sensors, mechanistic models and small-scale equipment for high-throughput experimentation. The manuscript ends with a short...

  11. PAT portable appliance testing

    CERN Document Server

    2011-01-01

    The Electricity at Work Regulations 1989 require any electrical system to be constructed, maintained and used in such a manner as to prevent danger. This means that inspection and testing of systems, including portable appliances, is needed in order to determine if maintenance is required.This book explains in clear language what needs to be done and includes expert advice on legislation as well as actual testing. The book contains an appendix providing the electrical fundamentals needed by non-specialists and also has sample questions (with answers) for the C&G 2377 exam that anyone who conducts this work is required to take by law.It is an affordable and handy reference for electricians who administer PAT. It is also an ideal refesher and revision guide for the non-specialist, such as maintenance staff, caretakers and charity shop volunteers who carry out these tasks part-time, alongside their many other duties.Brian Scaddan, I Eng, MIET, is a consultant for and an Honorary Member of City & Guilds. ...

  12. Astronaut Dale Gardner rehearses control of MMU during EVA practice

    Science.gov (United States)

    1984-01-01

    Astronaut Dale A. Gardner, 51-A mission specialist, rehearses control of manned maneuvering unit (MMU) during a practice for an extravehicular activity (EVA). Gardner is in the Shuttle mockup and integration laboratory at JSC.

  13. Ground water in Dale Valley, New York

    Science.gov (United States)

    Randall, Allan D.

    1979-01-01

    Dale Valley is a broad valley segment, enlarged by glacial erosion, at the headwaters of Little Tonawanda Creek near Warsaw , New York. A thin, shallow alluvial aquifer immediately underlies the valley floor but is little used. A deeper gravel aquifer, buried beneath many feet of lake deposits, is tapped by several industrial wells. A finite-difference digital model treated the deep aquifer as two-dimensional with recharge and discharge through a confining layer. It was calibrated by simulating (1) natural conditions, (2) an 18-day aquifer test, and (3) 91 days of well-field operation. Streamflow records and model simulations suggest that in moderately wet years such as 1974, a demand of 750 gallons per minute could be met by withdrawal from the creek and from the aquifer without excessive drawdown at production wells or existing domestic wells. With reasonable but unverified model adjustments to simulate an unusually dry year, the model predicts that a demand of 600 gallons per minute could be met from the same sources. Water high in chloride has migrated from bedrock into parts of the deep aquifer. Industrial pumpage, faults in the bedrock, and the natural flow system may be responsible. (Woodard-USGS)

  14. Professor Howard Mason and oxygen activation

    International Nuclear Information System (INIS)

    Waterman, Michael R.

    2005-01-01

    Our understanding of the classification, function, mechanism, and structure of the enzymes which incorporate atoms of oxygen from atmospheric molecular oxygen during catalysis is based on the thoughtful and technically challenging experiments of two giants in the field of Biochemistry, Howard Mason and Osamu Hayaishi. This volume celebrates the 50th anniversary of the discovery and characterization of these 'oxygenase' enzymes and provides a broad view of how far this area of research has advanced. Professor Hayaishi describes herein his perspective on the background and major discoveries which led to the development of this field. Regrettably Howard Mason passed away at age 88 in 2003. I am indeed fortunate to have been a Ph.D. student with Howard and to have the opportunity to briefly review his role in the development of this field for this special commemorative issue of BBRC

  15. Howard Feiertag receives hospitality industry award

    OpenAIRE

    Ho, Sookhan

    2004-01-01

    Howard Feiertag, of Blacksburg, an instructor in hospitality and tourism management at Virginia Tech's Pamplin College of Business, received the inaugural Excellence in Sales and Marketing Strategy Award at the Hospitality Sales and Marketing Association/New York University Strategy Conference in New York recently.

  16. Oral Histories in Meteoritics and Planetary Science - XX: Dale Cruikshank

    Science.gov (United States)

    Sears, Derek W. G.

    2013-04-01

    In this interview, Dale Cruikshank (Fig. 1) explains how as an undergraduate at Iowa State University he was a summer student at Yerkes Observatory where he assisted Gerard Kuiper in work on his Photographic Lunar Atlas. Upon completing his degree, Dale went to graduate school at the University of Arizona with Kuiper where he worked on the IR spectroscopy of the lunar surface. After an eventful 1968 trip to Moscow via Prague, during which the Soviets invaded Czechoslovakia, Dale assumed a postdoc position with Vasili Moroz at the Sternberg Astronomical Institute and more observational IR astronomy. Upon returning to the United States and after a year at Arizona, Dale assumed a position at the University of Hawai'i that he held for 17 years. During this period Dale worked with others on thermal infrared determinations of the albedos of small bodies beyond the asteroid Main Belt, leading to the recognition that low-albedo material is prevalent in the outer solar system that made the first report of complex organic solids on a planetary body (Saturn's satellite Iapetus). After moving to Ames Research Center, where he works currently, he continued this work and became involved in many outer solar system missions. Dale has served the community through his involvement in developing national policies for science-driven planetary exploration, being chair of the DPS 1990-1991 and secretary/treasurer for 1982-1985. He served as president of Commission 16 (Physics of Planets) of the IAU (2001-2003). He received the Kuiper prize in 2006.

  17. 76 FR 53964 - Dale J. Bingham, P.A.; Revocation of Registration

    Science.gov (United States)

    2011-08-30

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Dale J. Bingham, P.A.; Revocation of... Enforcement Administration, issued an Order to Show Cause to Dale J. Bingham, P.A. (Registrant), of Ash Fork... 28 CFR 0.100(b), I order that DEA Certificate of Registration MB1048746, issued to Dale J. Bingham, P...

  18. Astronaut Dale Gardner holds up for sale sign after EVA

    Science.gov (United States)

    1984-01-01

    Astronaut Dale A. Gardner, having just completed the major portion of his second extravehicular activity (EVA) period in three days, holds up a 'for sale' sign. Astronaut Joseph P. ALlen IV, who also participated in the two EVA's, is reflected in Gardner's helmet visor. A portion of each of two recovered satellites is in the lower right corner, with Westar nearer Discovery's aft.

  19. Aesthetics at the Impasse: The Unresolved Property of Dale Farm

    Science.gov (United States)

    McCarthy, Lynne

    2015-01-01

    "Soil Depositions" was an art activist project that responded to the 2011 Irish Traveller eviction at Dale Farm in Essex when three resident women donated small amounts of soil from the site of their former home. The soil was subsequently deposited, framed and documented in various national and international locations. This article…

  20. Dale Chihuly: An Inspiration in Art, Science, and Math!

    Science.gov (United States)

    Hubbert, Beth

    2009-01-01

    Connecting students to the arts in a concrete way can be an effective teaching tool. In this article, the author describes how Dale Chihuly's "Hart Window," which features hand-blown glass disks affixed to the framework of the window, can be an inspiration for interdisciplinary connections in art, science and math. (Contains 4 online resources.)

  1. American AV: Edgar Dale and the Information Age Classroom.

    Science.gov (United States)

    Acland, Charles R

    2017-01-01

    This article demonstrates how the influential scholar Edgar Dale, alongside a generation of educational technologists, helped build an essential place for AV materials and pedagogical methods in the American classroom. It also shows that, for decades, the Payne Fund philanthropy supported multimedia research agendas that shaped ideas about teaching and technology, far beyond involvement in their famed studies on motion pictures and children in the 1930s. With his writings and research programs, Dale advanced concepts of media experience and systematicity, which came to be understood as common sense to the information society. In so doing he was a leading contributor to the discursive and ideological structure of our age of technological and informational abundance.

  2. The Life and Work of Howard Zinn

    Directory of Open Access Journals (Sweden)

    Ambre Ivol

    2008-05-01

    Full Text Available In May 2003, « a publishing milestone » was celebrated in New York City, the sale of one million copies of A People’s History of the United States by radical historian Howard Zinn. The popularity of this book can be measured in various ways. The book has served as an inspiration to various American artists, such as film director and actor Tim Robbins, rock star Bruce Springsteen, lead singer Eddy Vedder from the band Pearl Jam and folksinger Ani Difranco. Zinn’s treatment of Christopher Colum...

  3. Mucocele fronto-ethmoïdale geante avec extension intracranienne ...

    African Journals Online (AJOL)

    Mucocele fronto-ethmoïdale geante avec extension intracranienne: a propos d'un cas et revue de la litterature. A Kabre, DS Zabsonre, Y Haro. Abstract. Les mucocèles sont des pseudotumeurs kystiques développées aux dépens des sinus paranasaux. D'évolution lente et silencieuse elles se révèlent le plus souvent par ...

  4. Howard University Engineers Success: Interdisciplinary Study Keeps Howard on the Cutting Edge

    Science.gov (United States)

    Chew, Cassie M.

    2004-01-01

    According to Engineering Workforce Commission annual reports, in 1999 Howard University graduated 108 students, 92 of whom were African American, in its chemical, civil, electrical, and mechanical engineering programs and computer science programs. After two more years of graduating approximately 100 students across programs, in 2002, according to…

  5. Howard H. Kendler (1919-2011).

    Science.gov (United States)

    Foley, John M

    2012-09-01

    Presents an obituary for Howard H. Kendler. Kendler was born in New York City on June 9, 1919, and died in Santa Barbara, California, on February 17, 2011. Kendler majored in psychology at Brooklyn College, where he was an assistant to Abraham Maslow, the father of humanistic psychology, and did a research project on the psychology of thinking under the supervision of Solomon Asch, a leading Gestalt psychologist. Howard Kendler's career was characterized by insightful experiments and a consistent analysis of the fundamental issues of the nature of our science, its methods, and its role in the community. The breadth of his knowledge and the depth of his thinking on these issues are rare. Although he did not settle these issues, he brought them into clear focus and forcefully advocated for his point of view. He was a visiting professor at the University of California, Berkeley, Hebrew University in Jerusalem, and Tel-Aviv University and was a fellow at the Center for Advanced Study in the Behavioral Sciences. He held the offices of president of the Western Psychological Association, chairman of the Board of Governors of the Psychonomic Society, and president of the Division of General Psychology and the Division of Experimental Psychology of the American Psychological Association. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  6. A GLIMPSE OF POSITIVE ACCOUNTING THEORY (PAT

    Directory of Open Access Journals (Sweden)

    Muhammad Rifky Santoso

    2017-11-01

    Full Text Available Positive accounting theory (PAT has been more developed than normative accounting theory in this era. The development of PAT research has discussed about what factors influenced management to report earnings. By using literature reviews, there are many researches in discussing the external factors to influence management to report earnings, such as bonuses, the debt equity ratio, political costs, and good governance. The other researches have discussed the association between earnings and stock prices. There are still few discussions about the selfmotivation of the directors or managers why choose a certain accounting method. The difference of environment, types of industry, and timing of financial statement reporting can be a further research. By using theories introduced by Popper, Kuhn, and Lakatos, PAT has elements in these three theories; however, PAT has not been categorized as science.

  7. Process analytical technology (PAT) for biopharmaceuticals

    DEFF Research Database (Denmark)

    Glassey, Jarka; Gernaey, Krist; Clemens, Christoph

    2011-01-01

    Process analytical technology (PAT), the regulatory initiative for building in quality to pharmaceutical manufacturing, has a great potential for improving biopharmaceutical production. The recommended analytical tools for building in quality, multivariate data analysis, mechanistic modeling, novel...

  8. ICAS-PAT: A Software for Design, Analysis and Validation of PAT Systems

    DEFF Research Database (Denmark)

    Singh, Ravendra; Gernaey, Krist; Gani, Rafiqul

    2010-01-01

    end product qualities. In an earlier article, Singh et al. [Singh, R., Gernaey, K. V., Gani, R. (2009). Model-based computer-aided framework for design of process monitoring and analysis systems. Computers & Chemical Engineering, 33, 22–42] proposed the use of a systematic model and data based...... methodology to design appropriate PAT systems. This methodology has now been implemented into a systematic computer-aided framework to develop a software (ICAS-PAT) for design, validation and analysis of PAT systems. Two supporting tools needed by ICAS-PAT have also been developed: a knowledge base...... (consisting of process knowledge as well as knowledge on measurement methods and tools) and a generic model library (consisting of process operational models). Through a tablet manufacturing process example, the application of ICAS-PAT is illustrated, highlighting as well, the main features of the software....

  9. Dale's Cone Revisited: Critically Examining the Misapplication of a Nebulous Theory to Guide Practice.

    Science.gov (United States)

    Subramony, Deepak, Prem

    2003-01-01

    Edgar Dale's (1946) Cone of Experience model-and various adaptations-have been used by practitioners for decades. However, little has been accomplished by way of examining and refining the model (and its associated theories). This article suggests several philosophical perspectives by which gaps in the prevalent version of Dale's Cone could be…

  10. Howard Brenner's Legacy for Biological Transport Processes

    Science.gov (United States)

    Nitsche, Johannes

    2014-11-01

    This talk discusses the manner in which Howard Brenner's theoretical contributions have had, and long will have, strong and direct impact on the understanding of transport processes occurring in biological systems. His early work on low Reynolds number resistance/mobility coefficients of arbitrarily shaped particles, and particles near walls and in pores, is an essential component of models of hindered diffusion through many types of membranes and tissues, and convective transport in microfluidic diagnostic systems. His seminal contributions to macrotransport (coarse-graining, homogenization) theory presaged the growing discipline of multiscale modeling. For biological systems they represent the key to infusing diffusion models of a wide variety of tissues with a sound basis in their microscopic structure and properties, often over a hierarchy of scales. Both scientific currents are illustrated within the concrete context of diffusion models of drug/chemical diffusion through the skin. This area of theory, which is key to transdermal drug development and risk assessment of chemical exposure, has benefitted very directly from Brenner's contributions. In this as in other areas, Brenner's physicochemical insight, mathematical virtuosity, drive for fully justified analysis free of ad hoc assumptions, quest for generality, and impeccable exposition, have consistently elevated the level of theoretical understanding and presentation. We close with anecdotes showing how his personal qualities and warmth helped to impart high standards of rigor to generations of grateful research students. Authors are Johannes M. Nitsche, Ludwig C. Nitsche and Gerald B. Kasting.

  11. Obituary: Howard H. Lanning, 1946-2007

    Science.gov (United States)

    Wade, Richard A.; MacConnell, D. Jack

    2009-01-01

    Howard H. Lanning died 20 December 2007 in Tucson, Arizona. He was a Software Quality Assurance Engineer for the Data Products Program at the National Optical Astronomy Observatory [NOAO] in Tucson, having returned to his native West after twenty years at the Space Telescope Science Institute [STScI] in Baltimore, Maryland. Throughout his career in roles supporting other astronomers, Howard steadily and persistently worked at his own research programs, most notably the identification and study of UV-bright sources in the Sandage Two-Color Survey of the Galactic Plane. Minor planet 2000 QJ248 has been named (61913) Lanning in recognition of his contributions. The son of James Clyde Lanning and Ethel Malan Lanning, Howard was born 26 May 1946, in Brawley, a small community near Calipatria, California. His parents worked for the local school district where his late father was Superintendent of Maintenance and Grounds and his mother was a school principal. After graduating from high school in a class of 52, Howard earned his A.A. degree at Imperial Valley Junior College, majoring in Astronomy and minoring in Mathematics. He completed his A.B. degree in Applied Arts and Sciences at San Diego State University [SDSU] in 1969 with the same major and minor. In 1974, he completed his M.S. in Astronomy at SDSU with a thesis on the period variation of the white-dwarf eclipsing binary BD +16∘516. During his time at SDSU Lanning was a Research Assistant/Observer at the former Hale Observatories, working on the optical identification of X-ray sources under the direction of Allan Sandage. His second refereed paper, the first of several finding lists of UV-bright stars arising from this work, appeared in 1973. Fellow students and faculty remember that he was a self-starter, initiating many observing projects of his own at Mount Laguna Observatory and encouraging others to do the same. For more than a decade Lanning was an observer and night assistant at Mount Wilson Observatory

  12. Antimatter/HiPAT Support Services

    Science.gov (United States)

    Lewis, Raymond A.

    2001-01-01

    Techniques were developed for trapping normal matter in the High Performance Antiproton Trap (HiPAT). Situations encountered included discharge phenomena, charge exchange and radial diffusion processes. It is important to identify these problems, since they will also limit the performance in trapping antimatter next year.

  13. Gladstone-Dale constant for CF4. [experimental design

    Science.gov (United States)

    Burner, A. W., Jr.; Goad, W. K.

    1980-01-01

    The Gladstone-Dale constant, which relates the refractive index to density, was measured for CF4 by counting fringes of a two-beam interferometer, one beam of which passes through a cell containing the test gas. The experimental approach and sources of systematic and imprecision errors are discussed. The constant for CF4 was measured at several wavelengths in the visible region of the spectrum. A value of 0.122 cu cm/g with an uncertainty of plus or minus 0.001 cu cm/g was determined for use in the visible region. A procedure for noting the departure of the gas density from the ideal-gas law is discussed.

  14. PAT-2 (Plutonium Air Transportable Model 2)

    International Nuclear Information System (INIS)

    Anderson, J.

    1981-01-01

    The PAT-2 (Plutonium Air Transportable Model 2) package is designed for the safe transport of plutonium and/or uranium in small quantities, especially as used in international safeguards activities, and especially as transported by air. The PAT-2 package is resistant to severe accidents, including that of a high-speed jet aircraft crash, and is designed to withstand such environments as extreme impact, crushing, puncturing and slashing loads, severe hydrocarbon-fueled fires, and deep underwater immersion, with no escape of contents. The accident environments may be imposed upon the package singly or seqentially. The package meets the requirements of 10 CFR 71 for Fissile Class I packages with a cargo of 15 grams of Pu-239, or other isotopic forms described herein, not to exceed 2 watts of thermal activity. Packaging, operational features, and contents of package, are discussed

  15. Change Strategies Used by a Proprietary School: The Dale Carnegie Organization.

    Science.gov (United States)

    Mackey, Paul J.

    1983-01-01

    Discusses recent developments regarding proprietary schools: recognition by accrediting associations, increased federal aid, and increased need for the specific training offered by these schools. Uses the Dale Carnegie organization as an example. (JOW)

  16. The Importance of Role Modeling in Mentoring Women: Lessons from Pat Summitt Legacy

    Directory of Open Access Journals (Sweden)

    Picariello Manuela

    2016-10-01

    Full Text Available The role of mentoring for women in sports industry has gathered attention among researchers in the past years (Bower, 2009; Bower, & Hums 2009, 2014; Weaver, & Chelladurai, 1999, 2002. Since few women are in leadership positions (Acosta, & Carpenter, 2014, cross-gender mentoring relationships are more likely to happen (Hopkins et al., 2008. However, according to Kram (1985, cross-gender mentoring relationships are more complex in terms of individual development and quality of the developmental relationship. In particular, role modeling function is limited (Kram, 1985. Therefore, the purpose of this study was to examine the functions of the same gender mentoring relationships looking at coach Pat Summitt, the winningest coach in NCAA Division I basketball history and a woman in leadership position (Becker & Wrisberg, 2008. Due to the exploratory nature of the study and the huge impact of Pat Summitt on sport (Janssen, & Dale, 2002, De Marco, & Mccullick, 1997, a single case study design to analyze her relationships from the staff and players’ perspectives was utilized as the method for data collection. This study collected data published on American news sites located using Internet search engines Google News (http://www.google.com for 7 days. The dataset included content published through national and regional online news media, radio, television and entertainment websites and blogs. Texts were qualitatively reviewed with a content analysis and coded (Patton, 2002. This study identified career and psychosocial functions that were important in developing an effective mentoring relationships. In particular, the psychosocial functions of “role modeling” was identified as the most important for the relationship. In fact a female mentor as a role model can be perceived as a woman that has successfully overcome discriminatory barriers to career advancement.

  17. Gladstone-Dale rule and its applicability to natural calcium borates

    International Nuclear Information System (INIS)

    Gode, G.K.; Spritse, D.P.

    1987-01-01

    Applicability of Gladstone-Dale rule, relating a dependence between the values of refractive index, density and chemical composition of the liquids, to 25 natural crystalline calcium borates (minerals) is determined. The given rule is stated to be applicable to 21 of them. Only for 4 borates with unclear chemical composition and inaccurate data on the density and refractive indices Gladstone-Dale rule variations are expressed by more significant values

  18. Role of gibberellins in parthenocarpic fruit development induced by the genetic system pat-3/pat-4 in tomato.

    Science.gov (United States)

    Fos, Mariano; Proaño, Karina; Nuez, Fernando; García-Martínez, José L.

    2001-04-01

    The role of gibberellins (GAs) in the induction of parthenocarpic fruit-set and growth by the pat-3/pat-4 genetic system in tomato (Lycopersicon esculentum Mill.) was investigated using wild type (WT; Cuarenteno) and a near-isogenic line derived from the German line RP75/59 (the source of pat-3/pat-4 parthenocarpy). Unpollinated WT ovaries degenerated but GA3 application induced parthenocarpic fruit growth. On the contrary, parthenocarpic growth of pat-3/pat-4 fruits, which occurs in the absence of pollination and hormone treatment, was not affected by applied GA3. Unpollinated pat-3/pat-4 fruit growth was negated by paclobutrazol, an inhibitor of ent-kaurene oxidase, and this inhibitory effect was negated by GA3. The quantification of the main GAs of the early 13-hydroxylation pathway (GA1, GA8, GA19, GA20, GA29 and GA44) in unpollinated ovaries at 3 developmental stages (flower bud, FB; pre-anthesis, PR; and anthesis, AN), by gas chromatography-selected ion monitoring, showed that the concentration of most of them was higher in pat-3/pat-4 than in WT ovaries at PR and AN stages. The concentration of GA1, suggested previously to be the active GA in tomate, was 2-4 times higher. Unpollinated pat-3/pat-4 ovaries at FB, PR and AN stages also contained relatively high amounts (5-12 ng g-1) of GA3, a GA found at less than 0.5 ng g-1 in WT ovaries. It is concluded that the mutations pat-3/pat-4 may induce natural facultative parthenocarpy capacity in tomato by increasing the concentration of GA1 and GA3 in the ovaries before pollination.

  19. Message from Terrence Howard: Screening for Colorectal Cancer PSA (:20)

    Centers for Disease Control (CDC) Podcasts

    2010-04-13

    A message from the actor/musician Terrence Howard about the importance of screening for colorectal cancer.  Created: 4/13/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/13/2010.

  20. Message from Terrence Howard: Screening for Colorectal Cancer PSA (:60)

    Centers for Disease Control (CDC) Podcasts

    2010-04-13

    A message from the actor/musician Terrence Howard about the importance of screening for colorectal cancer.  Created: 4/13/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 4/13/2010.

  1. PAT-1 safety analysis report addendum.

    Energy Technology Data Exchange (ETDEWEB)

    Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

    2010-09-01

    The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The purpose of this SAR Addendum is to incorporate plutonium (Pu) metal as a new payload for the PAT-1 package. The Pu metal is packed in an inner container (designated the T-Ampoule) that replaces the PC-1 inner container. The documentation and results from analysis contained in this addendum demonstrate that the replacement of the PC-1 and associated packaging material with the T-Ampoule and associated packaging with the addition of the plutonium metal content are not significant with respect to the design, operating characteristics, or safe performance of the containment system and prevention of criticality when the package is subjected to the tests specified in 10 CFR 71.71, 71.73 and 71.74.

  2. Dale Reed with model in front of M2-F1

    Science.gov (United States)

    1967-01-01

    Dale Reed with a model of the M2-F1 in front of the actual lifting body. Reed used the model to show the potential of the lifting bodies. He first flew it into tall grass to test stability and trim, then hand-launched it from buildings for longer flights. Finally, he towed the lifting-body model aloft using a powered model airplane known as the 'Mothership.' A timer released the model and it glided to a landing. Dale's wife Donna used a 9 mm. camera to film the flights of the model. Its stability as it glided--despite its lack of wings--convinced Milt Thompson and some Flight Research Center engineers including the center director, Paul Bikle, that a piloted lifting body was possible. The lifting body concept evolved in the mid-1950s as researchers considered alternatives to ballistic reentries of piloted space capsules. The designs for hypersonic, wingless vehicles were on the boards at NASA Ames and NASA Langley facilities, while the US Air Force was gearing up for its Dyna-Soar program, which defined the need for a spacecraft that would land like an airplane. Despite favorable research on lifting bodies, there was little support for a flight program. Dryden engineer R. Dale Reed was intrigued with the lifting body concept, and reasoned that some sort of flight demonstration was needed before wingless aircraft could be taken seriously. In February 1962, he built a model lifting body based upon the Ames M2 design, and air-launched it from a radio controlled 'mothership.' Home movies of these flights, plus the support of research pilot Milt Thompson, helped pursuade the facilities director, Paul Bikle, to give the go-ahead for the construction of a full-scale version, to be used as a wind-tunnel model and possibly flown as a glider. Comparing lifting bodies to space capsules, an unofficial motto of the project was, 'Don't be Rescued from Outer Space--Fly Back in Style.' The construction of the M2-F1 was a joint effort by Dryden and a local glider manufacturer, the

  3. The correspondence of Thomas Dale (1700-1750): Botany in the transatlantic Republic of Letters.

    Science.gov (United States)

    Cook, William J

    2012-03-01

    This paper seeks to provide a full account of the life and career of Dr. Thomas Dale (1700-1750), with particular reference to his botanical works and correspondence. Born in Hoxton, London, Dale studied medicine at Leiden and engaged fully in the social, literary and epistolary network in which botany was practised in eighteenth-century England. In 1730, however, Dale relocated to the British colonial port of Charles Town, South Carolina. Here he continued to engage in a transatlantic network of botanical exchange and discussion, corresponding on equal and reciprocal terms with his former colleagues in England. Where Dale differs from naturalists in South Carolina before him is that his motives for pursuing botany and for corresponding with English naturalists were located firmly in the New World. Such a conclusion forms a valuable, albeit small contribution to models for the development of national scientific cultures in the imperial world. Similarly, Dale's pursuit of botanical information in South Carolina provides a small amount of material with which to illustrate currently fashionable models for the mediated exchange and circulation of scientific knowledge. Copyright © 2011 Elsevier Ltd. All rights reserved.

  4. Annex 2: performance audit tool PAT

    Energy Technology Data Exchange (ETDEWEB)

    Kaldorf, S.; Gruber, P.

    2000-10-15

    This annex to the report takes a look at experience gained with one of two expert systems used for error-detection and diagnosis in existing buildings. The Performance Audit Tool PAT is based on an expert system for the detection and diagnosis of under-performance. Its aim is to assist the system's operator. It was developed as a stand-alone system which periodically runs a remote detection and diagnosis check. The various types of under-performance that the system can detect are discussed. The first objective of this study was to present the structure of the tool and describe its application to two types of system: a central air-handling unit and individual zones. The second objective was to discuss experience gained with this type of tool.

  5. A Conversation with Howard Schultz CEO of Starbucks

    OpenAIRE

    Christopher Muller

    2014-01-01

    At the 12th annual European Food Service Summit in Zurich, Switzerland in September 2011, Professor Christopher Muller sat down with Howard Schultz, the CEO of Starbucks to discuss a wide range of topics. Their discussion touched on best management and business practices and the techniques that Schultz used to bring Starbucks back from the brink of bankruptcy to the international coffee corporation it is today.

  6. A Conversation with Howard Schultz CEO of Starbucks

    Directory of Open Access Journals (Sweden)

    Christopher Muller

    2014-04-01

    Full Text Available At the 12th annual European Food Service Summit in Zurich, Switzerland in September 2011, Professor Christopher Muller sat down with Howard Schultz, the CEO of Starbucks to discuss a wide range of topics. Their discussion touched on best management and business practices and the techniques that Schultz used to bring Starbucks back from the brink of bankruptcy to the international coffee corporation it is today.

  7. Astronaut Dale Gardner using MMU to travel to Westar VI satellite

    Science.gov (United States)

    1984-01-01

    Astronaut Dale A. Gardner, wearing the manned maneuvering unit (MMU) approaching the spinng Westar VI satellite over Bahama Banks. Gardner uses a large tool called the apogee kick motor capture device (ACD) to enter the nozzle of the spent Westar engine and stabilize the satellite to capture it for return to Earth.

  8. Äripäev : Hiiumaa edukaim ettevõte on Dale LD AS / Urmas Lauri

    Index Scriptorium Estoniae

    Lauri, Urmas, 1956-

    2006-01-01

    Hiiumaa ettevõtete pingereas esimeseks tõusnud Dale LD AS-i tegevjuhi Tiit Asumetsa sõnul andis suurt efekti firma käibesse ja kasumisse Soome firmaga Ensto OY sõlmitud koostööleping. Lisa: Hiiumaa ettevõtete TOP aastal 2005

  9. The Mythical Retention Chart and the Corruption of Dale's Cone of Experience

    Science.gov (United States)

    Subramony, Deepak Prem; Molenda, Michael; Betrus, Anthony K.; Thalheimer, Will

    2014-01-01

    In response to the wide-scale proliferation of "the cone of learning"--a fanciful retention chart confounded with Dale's Cone of Experience--the authors make four major claims debunking this fantasy and provide documentary evidence to support these claims. The first claim is that the data in the mythical retention chart do not make…

  10. Astronat Dale Gardner using MMU to travel to Westar VI satellite

    Science.gov (United States)

    1984-01-01

    Astronat Dale A. Gardner appears to be under the remote manipulator system (RMS) end effector as he makes a turn in space and preapares to use the manned maneuvering unit (MMU) to travel to Westar VI satellite. The 'stinger' he carries will enter the communications satellite through the nozzle of the spent motor.

  11. Previous Attempts to Debunk the Mythical Retention Chart and Corrupted Dale's Cone

    Science.gov (United States)

    Subramony, Deepak Prem; Molenda, Michael; Betrus, Anthony K.; Thalheimer, Will

    2014-01-01

    Critics have been attempting to debunk the mythical retention chart at least since 1971. The earliest critics, David Curl and Frank Dwyer, were addressing just the retention data. Beginning around 2002, a new generation of critics has taken on the illegitimate combination of the retention chart and Edgar Dale's Cone of Experience--the corrupted…

  12. Dewey, Dale, and Bruner: Educational Philosophy, Experiential Learning, and Library School Cataloging Instruction.

    Science.gov (United States)

    Garrett, LeAnn

    1997-01-01

    Discusses educational philosophies of John Dewey, Edgar Dale, and Jerome Bruner dealing with experience and learning and describes experiential learning activities within the curriculum of the School of Library and Information Studies at the University of Hawaii. Results of a study examining student attitudes toward experiential learning are…

  13. Hellenism, Hebraism, and the Eugenics of Culture in E.M. Forster's Howards End

    OpenAIRE

    Jacobowitz, Seth

    2004-01-01

    Seth Jacobowitz, in his paper "Hellenism, Hebraism, and the Eugenics of Culture in E.M. Forster's Howards End," explores how the culturalist principles of Hellenism and Hebraism theorized by Matthew Arnold as the basis of Englishness in Culture and Anarchy (1869) were incorporated into the text of E.M. Forster's Howards End (1910) to show the close institutional and conceptual linkages Forster shared with Arnold. Further, Jacobowitz seeks to bring Howards End into dialog with Forster's only m...

  14. Howard's End: A Narrative Memoir of Political Contrivance, Neoconservative Ideology and the Australian History Curriculum

    Science.gov (United States)

    Taylor, Tony

    2009-01-01

    In August 2006, Australia's conservative prime minister John Howard convened a history summit in Canberra. The purported goal of the summit was the framing of a nationally-acceptable curriculum in Australian history. However, as this article suggests, Howard's hidden intention was to use the summit as a device for introducing a narrowly…

  15. Et in Arcadia Ego: El Mausoleo de Castle Howard

    Directory of Open Access Journals (Sweden)

    María Teresa Muñoz

    2012-12-01

    Full Text Available

    Resumen

    Todas las construcciones que pueblan el jardín de Castle Howard de una forma aparentemente azarosa, colocadas siempre sobre  pequeñas colinas, transmiten la sensación de ser objetos permanentemente observados, más que de ser ellos mismos  lugares de observación del territorio circundante. Son más receptores de la mirada que origen de ella y esta situación es especialmente relevante en el caso del mausoleo de  Hawksmoor, algo más que un pabellón o un hito en el paisaje, ya que es la culminación de un itinerario que recorre todas ellas y el contrapunto a la casa principal. El mausoleo es el edificio  más habitado y también el más cualificado desde el punto de vista espacial, el más cerrado y al mismo tiempo el más vacío,  el más inaccesible y el más cercano. Esta construcción circular puede ser contemplada con emoción desde la lejanía, pero  también invita a aproximarse a sus límites, hasta sentir casi físicamente la vitalidad de quien habita en el interior de esa  jaula de piedra, y que habitará allí para siempre recordándonos que, como afirmaba Erwin Panofsky, la muerte es el auténtico
    sujeto de la existencia en el paisaje arcádico.

    Palabras clave

    Castle Howard, paisaje, mausoleo, Hawksmoor, arcadia, muerte, Panofsky

    Abstract

    All buildings that populate the garden of Castle Howard in a seemingly random, always placed on small hills, convey the feeling of being constantly observed objects, rather than being themselves observation sites surrounding territory. They are  more the gaze receptors than its origin, and this is particularly relevant in the case of the mausoleum of Hawksmoor, more  than a pavilion or a landmark in the landscape as it is the culmination of an itinerary that covers all of them and the counterpoint to the main house. The mausoleum is the building most inhabited and the most qualified from the

  16. Structure of PatF from Prochloron didemni

    International Nuclear Information System (INIS)

    Bent, Andrew F.; Koehnke, Jesko; Houssen, Wael E.; Smith, Margaret C. M.; Jaspars, Marcel; Naismith, James H.

    2013-01-01

    The X-ray crystal structure of PatF from P. didemni was solved by the single-wavelength anomalous diffraction method to a resolution of 2.13 Å. Patellamides are macrocyclic peptides with potent biological effects and are a subset of the cyanobactins. Cyanobactins are natural products that are produced by a series of enzymatic transformations and a common modification is the addition of a prenyl group. Puzzlingly, the pathway for patellamides in Prochloron didemni contains a gene, patF, with homology to prenylases, but patellamides are not themselves prenylated. The structure of the protein PatF was cloned, expressed, purified and determined. Prenylase activity could not be demonstrated for the protein, and examination of the structure revealed changes in side-chain identity at the active site. It is suggested that these changes have inactivated the protein. Attempts to mutate these residues led to unfolded protein

  17. Multivariate PAT solutions for biopharmaceutical cultivation: current progress and limitations

    NARCIS (Netherlands)

    Mercier, S.M.; Diepenbroek, B.; Wijffels, R.H.; Streefland, M.

    2014-01-01

    Increasingly elaborate and voluminous datasets are generated by the (bio)pharmaceutical industry and are a major challenge for application of PAT and QbD principles. Multivariate data analysis (MVDA) is required to delineate relevant process information from large multi-factorial and multi-collinear

  18. Velocities in a Centrifugal PAT Operation: Experiments and CFD Analyses

    Directory of Open Access Journals (Sweden)

    Mariana Simão

    2017-12-01

    Full Text Available Velocity profiles originated by a pump as turbine (PAT were measured using an ultrasonic doppler velocimetry (UDV. PAT behavior is influenced by the velocity data. The effect of the rotational speed and the associated flow velocity variations were investigated. This research focuses, particularly, on the velocity profiles achieved for different rotational speeds and discharge values along the impeller since that is where the available hydraulic power is transformed into the mechanical power. Comparisons were made between experimental test results and computational fluid dynamics (CFD simulations. The used CFD model was calibrated and validated using the same conditions as the experimental facility. The numerical simulations showed good approximation with the velocity measurements for different cross-sections along the PAT system. The application of this CFD numerical model and experimental tests contributed to better understanding the system behavior and to reach the best efficiency operating conditions. Improvements in the knowledge about the hydrodynamic flow behavior associated with the velocity triangles contribute to improvements in the PAT concept and operation.

  19. Atmospheric Rivers, Climate Change, and the Howard Hanson Dam

    Science.gov (United States)

    Warner, M.; Mass, C.; Shaffer, K.; Brettman, K.

    2017-12-01

    All wintertime extreme precipitation and major flooding events in Western Washington are associated with Atmospheric Rivers (ARs), narrow bands of elevated integrated water vapor transport (IVT) stretching from the tropical Pacific Ocean to the Pacific Northwest coast. Several studies over the last decade have suggested that climate change could impact the intensity, frequency, timing, and structure of Pacific Northwest extreme precipitation. The Howard Hanson Dam is situated on the Green River in the central Cascade Mountains in Western Washington and is operated by the US Army Corps of Engineers (USACE) in Seattle. The reservoir behind the dam has two functions: It is the main water supply for the city of Tacoma and is filled during the summer months, and it is empty during winter months when it is used for flood risk management during AR events, protecting billions of dollars of infrastructure downstream. The reservoir is maintained by the Cascade Mountains' abundant winter snowpack and precipitation. Since the reservoir behind Howard Hanson Dam must be empty before the flood season starts and is reliant on snowpack and precipitation to fill in late spring, impacts due to climate change are important for how the USACE operates and manages flood risk and water supply in the future. This work describes changes in the structure, climatology, and seasonality of cool-season atmospheric rivers influencing the west coast of North America by examining the projections of Coupled Model Intercomparison Project 5 (CMIP5) climate simulations forced by the Representative Concentration Pathway (RCP) 8.5 scenario. There are only slight changes in AR frequency and seasonality between historical (1970-1999) and future (2070-2099) periods considering the most extreme days (99th percentile) in integrated water vapor transport (IVT) along the West Coast, particularly along the southern part of the U.S. west coast, where some changes in the most extreme events are statistically

  20. Extension of the Gladstone-Dale equation for flame flow field diagnosis by optical computerized tomography

    International Nuclear Information System (INIS)

    Chen Yunyun; Li Zhenhua; Song Yang; He Anzhi

    2009-01-01

    An extended model of the original Gladstone-Dale (G-D) equation is proposed for optical computerized tomography (OCT) diagnosis of flame flow fields. For the purpose of verifying the newly established model, propane combustion is used as a practical example for experiment, and moire deflection tomography is introduced with the probe wavelength 808 nm. The results indicate that the temperature based on the extended model is more accurate than that based on the original G-D equation. In a word, the extended model can be suitable for all kinds of flame flow fields whatever the components, temperature, and ionization are.

  1. USA kongresmen : afgaanide oopium ründab ka Eestit / Howard Coble ; interv. Krister Paris

    Index Scriptorium Estoniae

    Coble, Howard

    2006-01-01

    USA staazhikas poliitik Howard Coble käis Eestis kuulamas kogemusi võitlusest narkokaubandusega, mida peab terrorismi üheks põhimootoriks. Afganistani narkootikumid ja stabiilsus, Guantanamo vangilaagrid

  2. Howard University Energy Expert Systems Institute Summer Program (EESI)

    Science.gov (United States)

    Momoh, James A.; Chuku, Arunsi; Abban, Joseph

    1996-01-01

    Howard University, under the auspices of the Center for Energy Systems and Controls runs the Energy Expert Systems Institute (EESI) summer outreach program for high school/pre-college minority students. The main objectives are to introduce precollege minority students to research in the power industry using modern state-of-the-art technology such as Expert Systems, Fuzzy Logic and Artificial Neural Networks; to involve minority students in space power management, systems and failure diagnosis; to generate interest in career options in electrical engineering; and to experience problem-solving in a teamwork environment consisting of faculty, senior research associates and graduate students. For five weeks the students are exposed not only to the exciting experience of college life, but also to the inspiring field of engineering, especially electrical engineering. The program consists of lectures in the fundamentals of engineering, mathematics, communication skills and computer skills. The projects are divided into mini and major. Topics for the 1995 mini projects were Expert Systems for the Electric Bus and Breast Cancer Detection. Topics on the major projects include Hybrid Electric Vehicle, Solar Dynamics and Distribution Automation. On the final day, designated as 'EESI Day' the students did oral presentations of their projects and prizes were awarded to the best group. The program began in the summer of 1993. The reaction from the students has been very positive. The program also arranges field trips to special places of interest such as the NASA Goddard Space Center.

  3. The Solar Eclipse Mural Series by Howard Russell Butler

    Science.gov (United States)

    Pasachoff, J. M.; Olson, R. J. M.

    2016-01-01

    There is a rich trove of astronomical phenomena in works of art by artists from the greater New York area, a trend that is even more pronounced in the oeuvres of New York City residents through the present day. A case in point is the trio of oil paintings by artist (and former physics professor) Howard Russell Butler depicting total solar eclipses in 1918, 1923, and 1925 that are based on his own observations. They were long displayed in the former art-deco building of the Hayden Planetarium of the American Museum of Natural History, the location of this conference. (The Museum also has nine other Butler paintings, none of which are currently exhibited.) Since the eclipse paintings have been in storage for many years, these once famous works are now virtually forgotten. Based on our research as an astronomer who has seen sixty-two solar eclipses and an art historian who has written extensively about astronomical imagery, we will discuss Butler's Solar Eclipse Triptych to explore its place in the history of astronomical imaging.

  4. PEMIKIRAN HOWARD GARDNER DALAM PENDIDIKAN ANAK USIA DINI

    Directory of Open Access Journals (Sweden)

    Muhibuddin Fadhli

    2016-12-01

    Full Text Available Promises independence Indonesia has spoken by the agents of history, one promise is the co-educating the nation, of course, those promises have not been fully met, that generation has passed, but not with the spoken promise, that promise will remain imprinted in the minds of the generations thereafter , we have to participate repay the appointment, although mouth did not give yet a calling of souls who move the hearts and minds to intervene to guide the realization of this promise. By nature children are born with millions of uniqueness, even children are not always visible twins are similar in all respects, be aware that the duty to educate children inherent in every human being, to educate is to lead children and all human beings are born to be a leader. Educating is not the work, especially of that educating should be higher than just earn money, educate should be fair, be understandable, and brought the child to the noble human decency. This article will discuss educating children in terms of various aspects of the philosophical and theoretical thinking by Howard Gardner

  5. Roswell Park Cancer Institute/Howard University Prostate Cancer Scholars Program

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-14-1-0531 TITLE: Roswell Park Cancer Institute/Howard University Prostate Cancer Scholars Program PRINCIPAL INVESTIGATOR...Roswell Park Cancer Institute/Howard University Prostate Cancer 5a. CONTRACT NUMBER W81XWH-14-1-0531 Cancer Scholars Program 5b. GRANT NUMBER 5c...Prostate Cancer Scholars Program is designed to encourage students from under-represented minority groups to enter graduate training and ultimately

  6. Using PAT to accelerate the transition to continuous API manufacturing

    DEFF Research Database (Denmark)

    de Gouveia, Maria Francisca Dias Folque; Rahbek, Jesper P.; Mortensen, Asmus R.

    2017-01-01

    the following: speeding up the design of the continuous process and a better understanding of the manufacturing requirements to ensure optimal yield and avoid unreacted raw materials and by-products in the continuous reactor effluent. Graphical Abstract Using PAT to accelerate the transition to continuous API......Significant improvements can be realized by converting conventional batch processes into continuous ones. The main drivers include reduction of cost and waste, increased safety, and simpler scale-up and tech transfer activities. Re-designing the process layout offers the opportunity to incorporate...... a set of process analytical technologies (PAT) embraced in the Quality-by-Design (QbD) framework. These tools are used for process state estimation, providing enhanced understanding of the underlying variability in the process impacting quality and yield. This work describes a road map for identifying...

  7. Dėl baltų *pat(is, *pat(nī pirminės reikšmės ir gramatinio statuso

    Directory of Open Access Journals (Sweden)

    Albertas Rosinas

    2011-11-01

    Full Text Available ON THE ORIGINAL MEANING AND THE GRAMMATICAL STATUS OF BALTIC *pat(is, *pat(nīSummaryOn the basis of the data from the Baltic and other Indo-European languages, the article rejects the common current view that Baltic *pat-root nouns, cf. Latv. pats ‘master, mister, husband’, pati ‘mistress, wife’, evolved from *pat-root pronouns with the meaning of ‘self’. The data from the Baltic languages lead to the conclusion that from Proto-Indo-European the Proto-Balts inherited the root noun of the consonantal declension *pat (pat (cf. I.-E. acc. sing. *potn̥> Baltic *patin and i-stem acc. sing. *avin passed to the i-stem declension, i. e. it was modified to *patis and began to be declined as an i-stem noun, although also retaining some C-stem forms; under the influence of the *patis model, *patnī gradually lost the suffix *-n- and became *patī (>Lith. patì, Latv. pati. The assumption that the Baltic nouns *patis, *patnī did not evolve from pronouns could be supported by the following: (a i-stem resp. C-stem pronominal paradigms are not characteristic of the Baltic pronominal systems; (b moreover, the Prussian language (like the German, Slavonic and Indo-Iranian languages never possessed *pat-root pronouns.In the East Baltic languages, pronouns with the meaning of ‘self’ evolved from the nouns *pat(is, *pat(nī in the process of pronominalization, which originally occurred in the sphere of the addressee and the non-participant person. In the process of pronominalization, *pat(is eventually acquired endings typical of pronouns, cf. dat. sing, pačiam <— pačiamu(i, ines. sing, patime and a newer form pačiame, dat. pl. patiems ← patiemus.The identifying particle pat in the collocative pronouns toks pat, tokia pat

  8. The "in-between writer": Howard Stein, PhD, professor emeritus, psycho-analytic anthropologist, poet, educator, transdisciplinary scholar.

    Science.gov (United States)

    Reilly, Jo Marie

    2016-09-01

    This commentary reflects the professional life story of a prolific and well-published poet, Howard Stein. An anthropologist by training, Howard's poetry is well known and well respected by family physicians. It is within family medicine that Howard found his professional home, and in his 45-plus-year career he has shared the value of "patient story"; the value of the doctor-patient relationship; and the art of listening deeply to self, colleagues, and patients. This commentary offers a tribute to Howard's professional life and his contributions to family and narrative medicine. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  9. Cosmopolitanism and Our Descriptions of Ethics and Ontology: A Response to Dale Snauwaert's "The Ethics and Ontology of Cosmopolitanism"

    Science.gov (United States)

    Hansen, David T.

    2010-01-01

    In recent years scholars across the humanities and social sciences have revitalized the ancient concept of cosmopolitanism. Dale Snauwaert illuminates why this is so in his thoughtful article on what it might mean to educate for a shared humanity. Snauwaert shows why many people find so-called "realism" an unsatisfactory political and moral…

  10. A unique finding of a great helm from the Dalečín Castle in Moravia

    Czech Academy of Sciences Publication Activity Database

    Cisár, V.; Hošek, Jiří; Žákovský, P.

    2012-01-01

    Roč. 8, prosinec (2012), s. 91-125 ISSN 1895-4103 R&D Projects: GA ČR GAP405/12/2289 Institutional support: RVO:67985912 Keywords : great helm * Dalečín * metallographic examination Subject RIV: AC - Archeology, Anthropology, Ethnology

  11. PAT challenges routine techniques on defect spectroscopy in material science

    International Nuclear Information System (INIS)

    Badawi, E.A.

    2005-01-01

    Atomic or Point Defects are the most simple defects in solids. Due to the small size their direct observation by the routine techniques is not possible. A single type of defects (thermal defect) was observed in the quenching process. Using the Arrhenius method and threshold method we recommended the accurate both method of treatments. The calculated values for formation enthalpies and self-diffusion using positron lifetime and Doppler broadening in a good agreement in (A356.0) and (A413.1). Specifically it is show how PAT detect defect concentrations, (formation- migration) enthalpies and grain size for the material under investigation. Most of the these data are reported

  12. Plutonium air transportable package Model PAT-1. Safety analysis report

    International Nuclear Information System (INIS)

    1978-02-01

    The document is a Safety Analysis Report for the Plutonium Air Transportable Package, Model PAT-1, which was developed by Sandia Laboratories under contract to the Nuclear Regulatory Commission (NRC). The document describes the engineering tests and evaluations that the NRC staff used as a basis to determine that the package design meets the requirements specified in the NRC ''Qualification Criteria to Certify a Package for Air Transport of Plutonium'' (NUREG-0360). By virtue of its ability to meet the NRC Qualification Criteria, the package design is capable of safely withstanding severe aircraft accidents. The document also includes engineering drawings and specifications for the package. 92 figs, 29 tables

  13. Unpacking Pat Parker: Intersections and Revolutions in "Movement in Black".

    Science.gov (United States)

    Washburn, Amy

    2015-01-01

    This article explores Pat Parker's poem "Movement in Black." It examines the ways in which she emblematizes intersectionality and simultaneity as forms of revolution in struggles of self and society. It begins with a theoretical and historical apparatus to contextualize Parker as an artist and activist. Then it offers a literary analysis of the poem, focusing on themes of time and space, marginalization and movement, difference and power, visibility and invisibility, and history and memory. It argues that Parker uses autobiographical writing to fuse personal and political sites of resistance.

  14. Construction and operation of the Howard T. Ricketts Laboratory.

    Energy Technology Data Exchange (ETDEWEB)

    Van Lonkhuyzen, R.; Stull, L.; Butler, J.; Chang, Y.; Allison, T.; O' Rourke, D.

    2006-01-01

    The National Institutes of Health (NIH) has proposed to partially fund the construction of the Howard T. Ricketts (HTR) regional biocontainment laboratory (RBL) by the University of Chicago at the U.S. Department of Energy's (DOE's) Argonne National Laboratory in Argonne, Illinois. The HTR Laboratory (HTRL) would be constructed, owned, and operated by the University of Chicago on land leased to it by DOE. The preferred project site is located north of Eastwood Drive and west of Outer Circle Road and is near the biological sciences building. This environmental assessment addresses the potential environmental effects resulting from construction and operation of the proposed facility. The proposed project involves the construction of a research facility with a footprint up to approximately 44,000 ft{sup 2} (4,088 m{sup 2}). The proposed building would house research laboratories, including Biosafety Level 2 and 3 biocontainment space, animal research facilities, administrative offices, and building support areas. The NIH has identified a need for new facilities to support research on potential bioterrorism agents and emerging and re-emerging infectious diseases, to protect the nation from such threats to public health. This research requires specialized laboratory facilities that are designed, managed, and operated to protect laboratory workers and the surrounding community from accidental exposure to agents. The proposed HTRL would provide needed biocontainment space to researchers and promote the advancement of knowledge in the disciplines of biodefense and emerging and re-emerging infectious diseases. Several alternatives were considered for the location of the proposed facility, as well as a no action alternative. The preferred alternative includes the construction of a research facility, up to 44,000 ft{sup 2} (4,088 m{sup 2}), at Argonne National Laboratory, a secure government location. Potential impacts to natural and cultural resources have been

  15. Solar-energy-system performance evaluation: Northview Elementary School (Howard's Grove) Howard's Grove, Wisconsin, September 1978-April 1979

    Energy Technology Data Exchange (ETDEWEB)

    Shenfish, K.L.

    1979-01-01

    The Northview Elementary School in Howard's Grove, Wisconsin is provided space heating by a system consisting of an array of flat plate air collectors and a rock bed. Auxiliary heat is supplied by a fuel oil boiler. The system and its operation are briefly described, and its performance is analyzed using a system energy balance technique. The performance of major subsystems is also presented. (LEW)

  16. Written Assignments for Abnormal Psychology at Howard Community College, Fall 1988.

    Science.gov (United States)

    Bell, James

    Designed for students enrolled in an Abnormal Psychology course at Howard Community College (Maryland), this booklet explains the requirements for the course's writing assignments, which are designed to teach the skills of comparison and contrast, analysis, critical thinking, and synthesis. Following an overview of class assignments and…

  17. Howard Gardner: Knowledge, Learning and Development in Drama and Arts Education.

    Science.gov (United States)

    Roper, Bill; Davis, David

    2000-01-01

    Notes that Howard Gardner's theory of Multiple Intelligences (MI) has afforded support to educators and parents who want to see their children as equals no matter in what area of ability they develop competence. Explains the usefulness of Gardner's approach, based on Kantian notions of the power of mind to give order to the world. Discusses the…

  18. The Pragmatic Idealist: Valerie Gross--Howard County Library, Columbia, MD

    Science.gov (United States)

    Library Journal, 2004

    2004-01-01

    In the two years since Valerie Gross became director of the Howard County Library (HCL), it has won the county's Community Organization of the Year award, its Accessibility Award, and its Chamber of Commerce's Non-Profit Business of the Year ACE award for contributions to education, economic development, and quality of life. And for the first…

  19. The Howard University Program in Atmospheric Sciences (HUPAS): A Program Exemplifying Diversity and Opportunity

    Science.gov (United States)

    Morris, Vernon R.; Joseph, Everette; Smith, Sonya; Yu, Tsann-wang

    2012-01-01

    This paper discusses experiences and lessons learned from developing an interdisciplinary graduate program (IDP) during the last 10 y: The Howard University Graduate Program in Atmospheric Sciences (HUPAS). HUPAS is the first advanced degree program in the atmospheric sciences, or related fields such as meteorology and earth system sciences,…

  20. Identification of a mutation associated with fatal Foal Immunodeficiency Syndrome in the Fell and Dales pony.

    Directory of Open Access Journals (Sweden)

    Laura Y Fox-Clipsham

    2011-07-01

    Full Text Available The Fell and Dales are rare native UK pony breeds at risk due to falling numbers, in-breeding, and inherited disease. Specifically, the lethal Mendelian recessive disease Foal Immunodeficiency Syndrome (FIS, which manifests as B-lymphocyte immunodeficiency and progressive anemia, is a substantial threat. A significant percentage (∼10% of the Fell ponies born each year dies from FIS, compromising the long-term survival of this breed. Moreover, the likely spread of FIS into other breeds is of major concern. Indeed, FIS was identified in the Dales pony, a related breed, during the course of this work. Using a stepwise approach comprising linkage and homozygosity mapping followed by haplotype analysis, we mapped the mutation using 14 FIS-affected, 17 obligate carriers, and 10 adults of unknown carrier status to a ∼1 Mb region (29.8 - 30.8 Mb on chromosome (ECA 26. A subsequent genome-wide association study identified two SNPs on ECA26 that showed genome-wide significance after Bonferroni correction for multiple testing: BIEC2-692674 at 29.804 Mb and BIEC2-693138 at 32.19 Mb. The associated region spanned 2.6 Mb from ∼29.6 Mb to 32.2 Mb on ECA26. Re-sequencing of this region identified a mutation in the sodium/myo-inositol cotransporter gene (SLC5A3; this causes a P446L substitution in the protein. This gene plays a crucial role in the regulatory response to osmotic stress that is essential in many tissues including lymphoid tissues and during early embryonic development. We propose that the amino acid substitution we identify here alters the function of SLC5A3, leading to erythropoiesis failure and compromise of the immune system. FIS is of significant biological interest as it is unique and is caused by a gene not previously associated with a mammalian disease. Having identified the associated gene, we are now able to eradicate FIS from equine populations by informed selective breeding.

  1. Thermodynamics and Chemistry by Howard DeVoe

    Science.gov (United States)

    Gislason, Eric A.

    2001-09-01

    Prentice Hall: Upper Saddle River, NJ, 2001. 439 pp. ISBN 0-02-328741-1. $90.00. Thermodynamics is a deceptively difficult subject that few people master in their first exposure (typically in the junior-level physical chemistry course). Because of this, a clear, well-written textbook is always welcome to help students and teachers master this material. Such a book is Thermodynamics and Chemistry, by Howard DeVoe of the University of Maryland. This book is written as a one-semester textbook for senior undergraduates and graduate students who have had a previous course on the topic. This is a long book (400 pages of text, 25 pages of appendices), and it is unlikely that an instructor can cover everything in one semester. On the other hand this length does allow the author to cover topics such as a "liquid solution in a centrifugal field" that shorter books would omit. All important topics in chemical thermodynamics are covered. After two introductory chapters, the three laws of thermodynamics are taken up in Chapters 3 and 4. Pure substances, including phase transitions, are treated in Chapters 5 and 6. Chapter 7, "Mixtures," is a long chapter that covers, among other topics, partial molar quantities, activities, and activity coefficients. Chemical reactions are treated in Chapter 8 and there is a detailed discussion of equilibrium in various multicomponent systems in Chapter 9. The book is completed with a discussion of the phase rule (Chapter 10) and a brief chapter on galvanic cells. There are a number of things I like about this book. First, DeVoe takes great care in defining important thermodynamic words such as the thermodynamic state of a system. Similarly, he makes the distinction between process and path understandable, and this allows him to clearly define a reversible process as well as spontaneous and impossible processes. Section 4.1 then contains the sentence "An irreversible process is a spontaneous process whose reverse is an impossible process." This

  2. Water physics and chemistry data from STD casts from THELMA DALE II and other platforms from 09 August 1954 to 05 March 1959 (NODC Accession 7101380)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Water physics and chemistry data were collected from STD casts from THELMA DALE II and other platforms from 09 August 1954 to 05 March 1959. Data were submitted by...

  3. Process analytical technology (PAT) tools for the cultivation step in biopharmaceutical production

    NARCIS (Netherlands)

    Streefland, M.; Martens, D.E.; Beuvery, E.C.; Wijffels, R.H.

    2013-01-01

    The process analytical technology (PAT) initiative is now 10 years old. This has resulted in the development of many tools and software packages dedicated to PAT application on pharmaceutical processes. However, most applications are restricted to small molecule drugs, mainly for the relatively

  4. Monitoring of radon gas in caves of the Yorkshire Dales, United Kingdom

    International Nuclear Information System (INIS)

    Langridge, D; Stokes, R P; Jackson, C P

    2010-01-01

    A number of vocational training courses are held in caves in the Yorkshire Dales region of the United Kingdom. The instructors and students involved in these courses have the potential to be exposed to enhanced levels of radon ( 222 Rn) and its progeny as a result of their occupations. A prior radiological risk assessment for the training courses recommended that an environmental monitoring programme be carried out to establish the radon concentrations in the caves, and that the caving instructors wear personal radon dosemeters. Radon gas concentrations varied seasonally, being at their highest in summer and their lowest in winter. The lowest result was 40 Bq m -3 recorded in Lower Longchurn cave during winter, whilst the highest result was 4440 Bq m -3 recorded in Crackpot cave during the summer. As the individuals involved in the caving are entering atmospheres with radon gas concentrations in excess of 400 Bq m -3 , the Ionising Radiation Regulations 1999 (GB Parliament 2000 Ionising Radiations Regulations 1999 (London: Stationary Office) SI 1999/3232) apply. A system of work is therefore in place to control exposure to radon. This system of work stipulates an initial dose investigation level of 1 mSv, a second dose investigation level of 2 mSv and an annual dose limit of 6 mSv. The highest annual dose recorded to date is 2.2 mSv, although the average (median) annual dose is only 0.5 mSv.

  5. Dynamic recrystallization mechanisms and their transition in the Daling Thrust (DT) zone, Darjeeling-Sikkim Himalaya

    Science.gov (United States)

    Ghosh, Subhajit; Bose, Santanu; Mandal, Nibir; Dasgupta, Sujoy

    2016-04-01

    The Daling Thrust (DT) delineates a zone of intense shear localization in the Lesser Himalayan Sequence (LHS) of the Darjeeling-Sikkim Himalaya. From microstructural studies of deformed quartzite samples, we show a transition in the dynamic recrystallization mechanism with increasing distance from the DT, dominated by grain boundary bulging (BLG) recrystallization closest to the DT, and progressively replaced by sub-grain rotation (SGR) recrystallization away from the thrust. The transition is marked by a characteristic variation in the fractal dimension (D) of grain boundaries, estimated from the area-perimeter method. For the BLG regime, D ≈ 1.046, which decreases significantly to a value as low as 1.025 for the SGR regime. Using the available thermal data for BLG and SGR recrystallization, we infer increasing deformation temperatures away from the DT in the hanging wall. Based on the quartz piezometer our estimates reveal strong variations in the flow stress (59.00 MPa to 16.00 MPa) over a distance of 1.2 km from the DT. Deformation mechanism maps constructed for different temperatures indicate that the strain rates (10- 12 S- 1 to 10- 14 S- 1) comply with the geologically possible range. Finally, we present a mechanical model to provide a possible explanation for the cause of stress intensification along the DT.

  6. UN_PAT: a software for calculating transient grounding potential

    Directory of Open Access Journals (Sweden)

    Johny Hernán Montaña

    2006-09-01

    Full Text Available This paper presents results from work done at the National University of Colombia and from a PhD thesis written there. This work was aimed at implementing software for analysing the transient behaviour of any configuration of grounding system buried in lineal, homogeneous and isotropic soil. The hybrid electromagnetic model (HEM was used because it presents high versatility and low computation time. The UN_PAT software was written in C++; it used free libraries with the aim of being free software so that it could be modified and improved in future work. The software results were validated with other software, with results from another analysis model and experimental results; some of these comparisons are given in this paper.

  7. Processing of baby food using pressure-assisted thermal sterilization (PATS) and comparison with thermal treatment

    Science.gov (United States)

    Wang, Yubin; Ismail, Marliya; Farid, Mohammed

    2017-10-01

    Currently baby food is sterilized using retort processing that gives an extended shelf life. However, this type of heat processing leads to reduction of organoleptic and nutrition value. Alternatively, the combination of pressure and heat could be used to achieve sterilization at reduced temperatures. This study investigates the potential of pressure-assisted thermal sterilization (PATS) technology for baby food sterilization. Here, baby food (apple puree), inoculated with Bacillus subtilis spores was treated using PATS at different operating temperatures, pressures and times and was compared with thermal only treatment. The results revealed that the decimal reduction time of B. subtilis in PATS treatment was lower than that of thermal only treatment. At a similar spore inactivation, the retention of ascorbic acid of PATS-treated sample was higher than that of thermally treated sample. The results indicated that PATS could be a potential technology for baby food processing while minimizing quality deterioration.

  8. The pat1 protein kinase controls transcription of the mating-type genes in fission yeast

    DEFF Research Database (Denmark)

    Nielsen, O; Egel, R; Nielsen, Olaf

    1990-01-01

    . This differentiation process is characterized by a transcriptional induction of the mating-type genes. Conjugation can also be induced in pat1-ts mutants by a shift to a semi-permissive temperature. The pat1 gene encodes a protein kinase, which also functions further downstream in the developmental pathway controlling...... of the mating-type genes in the zygote leads to complete loss of pat1 protein kinase activity causing entry into meiosis. Thus, pat1 can promote its own inactivation. We suggest a model according to which a stepwise inactivation of pat1 leads to sequential derepression of the processes of conjugation......The developmental programme of fission yeast brings about a transition from mitotic cell division to the dormant state of ascospores. In response to nitrogen starvation, two cells of opposite mating type conjugate to form a diploid zygote, which then undergoes meiosis and sporulation...

  9. 绚丽秀美,气势迫人 Pat Metheny/Brad Mehldau 《Metheny Mehldau》

    Institute of Scientific and Technical Information of China (English)

    马其发

    2007-01-01

    <正>爵士吉他高手Pat Metheny的作品通常"兵分两路",一是以Pat Metheny Group集体创作出碟,玩Crossover Jazz或Fusjon为主;另一是以Pat Metheny名义与一些乐坛名宿合作,玩Contemporary Jazz、Folk Jazz和

  10. Chemometrics-based process analytical technology (PAT) tools: applications and adaptation in pharmaceutical and biopharmaceutical industries.

    Science.gov (United States)

    Challa, Shruthi; Potumarthi, Ravichandra

    2013-01-01

    Process analytical technology (PAT) is used to monitor and control critical process parameters in raw materials and in-process products to maintain the critical quality attributes and build quality into the product. Process analytical technology can be successfully implemented in pharmaceutical and biopharmaceutical industries not only to impart quality into the products but also to prevent out-of-specifications and improve the productivity. PAT implementation eliminates the drawbacks of traditional methods which involves excessive sampling and facilitates rapid testing through direct sampling without any destruction of sample. However, to successfully adapt PAT tools into pharmaceutical and biopharmaceutical environment, thorough understanding of the process is needed along with mathematical and statistical tools to analyze large multidimensional spectral data generated by PAT tools. Chemometrics is a chemical discipline which incorporates both statistical and mathematical methods to obtain and analyze relevant information from PAT spectral tools. Applications of commonly used PAT tools in combination with appropriate chemometric method along with their advantages and working principle are discussed. Finally, systematic application of PAT tools in biopharmaceutical environment to control critical process parameters for achieving product quality is diagrammatically represented.

  11. APPLICATION OF THE HOWARD'S MODEL ON CONSUMER BEHAVIOR IN BUYING INSURANCE POLICY

    OpenAIRE

    Martje Paais; Semuel Souhoka

    2017-01-01

    This research intends to predict factors that drive consumer to buy insurance policy, based on consumer behavior model by Howard. In main variable used is buying decision. In addition, this study also includes information, brand image, confidence and attitude as the control variables. The analysis units are exclusive policy insured in Malang region. The data was collected using questionnaire. The t-test in simple regression models are used to test hypotheses. The research finds about: first, ...

  12. Victorian telescope makers. The lives and letters of Thomas and Howard Grubb.

    Science.gov (United States)

    Glass, I. S.

    This book is the story of a highly specialized and unusual nineteenth-century business enterprise. Makers of some of the largest and best known telescopes of the Victorian era, the Grubbs of Dublin were at the forefront of optical and mechanical engineering. For 95 years Thomas and Howard Grubb, father and son, supplied astronomical instruments to the world. Through extensive use of their original letters and documents the author has allowed the Grubbs to speak for themselves.

  13. The Howard University Program in Atmospheric Sciences: A Program Exemplifying Diversity and Excellence

    Science.gov (United States)

    Morria, V. R.; Demoz, B.; Joseph, E.

    2017-12-01

    The Howard University Graduate Program in Atmospheric Sciences (HUPAS) is the first advanced degree program in the atmospheric sciences instituted at a Historically Black College/University (HBCU) or at a Minority-Serving Institution (MSI). MSI in this context refers to academic institutions whose histories are grounded in serving minority students from their inception, rather than institutions whose student body demographics have evolved along with the "browning of America" and now meet recent Federal criteria for "minority-serving". HUPAS began in 1996 when initiatives within the Howard University Graduate School overlapped with the motivations of investigators within a NASA-funded University research center for starting a sustainable interdisciplinary program. After twenty years, the results have been the production of greater institutional depth and breadth of research in the geosciences and significant production of minority scientists contributing to the atmospheric sciences enterprise in various sectors. This presentation will highlight the development of the Howard University graduate program in atmospheric sciences, its impact on the national statistics for the production of underrepresented minority (URM) advanced degree holders in the atmospheric sciences, and some of the program's contributions to the diversity in geosciences and the National pipeline of talent from underrepresented groups. Over the past decade, Howard University is leading producer of African American and Hispanic female doctorates in atmospheric sciences - producing nearly half of all degree holders in the Nation. Specific examples of successful partnerships between this program and federal funding agencies such as NASA and NOAA which have been critical in the development process will also be highlighted. Finally, some of the student recruitment and retention strategies that have enabled the success of this program and statistics of student graduation will also be shared and

  14. Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

    DEFF Research Database (Denmark)

    Simon, Levente L.; Pataki, Hajnalka; Marosi, György

    2015-01-01

    in industrial laboratories and in manufacture e.g. at GSK, AstraZeneca and Roche. Furthermore, the paper discusses the PAT paradigm from the regulatory science perspective. Given the multidisciplinary nature of PAT, such an endeavour would be almost impossible for a single author, so the concept...... of a multiauthor review was born. Each section of the multiauthor review has been written by a single expert or group of experts with the aim to report on its own research results. This paper also serves as a comprehensive source of information on PAT topics for the novice reader....

  15. The Underappreciated Doctors of The American Civil Rights Movement. Part I: Theodore Roosevelt Mason Howard, MD.

    Science.gov (United States)

    deShazo, Richard D; Parker, Sara B

    2017-07-01

    During the fight to end segregation in the United States, most of the 25 or so black physicians who had not already left Mississippi took risks to become active in civil rights locally and nationally. One of the first was T.R.M. Howard, MD, whose life story is both an encouragement and warning for today's physicians. Howard, the protégé of a white Adventist physician, became active in civil rights during medical school. While serving as chief surgeon of the all-black hospital in Mississippi, he formed his own civil rights organization in 1951 and worked to solve the shootings of 2 of its members, George Lee and Gus Courts, and the murder of Emmett Till in 1955. His reports of these events and collaborations with other civil rights icons helped trigger the modern civil rights movement. At the same time, he became a nationally known proponent of abortion rights and then fled to Chicago in 1956, after arming his Delta mansion with long guns and a Thompson machine gun. Howard will be remembered for many things, including his activism for the social determinants of health as president of the National Medical Association. Copyright © 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  16. New PAT tools for assessing content uniformity, sampling error, and degree of crystallinity in pharmaceutical tablets

    DEFF Research Database (Denmark)

    Warnecke, Solveig

    of the pharmaceutical drug, both during development and throughout the production. The usage of PAT tools is encouraged by the regulatory authorities, and therefore the interest in new and improved PAT tools is increasing. The main purpose of introducing Quality by Design (QbD) and PAT in pharmaceutical production...... practice in traditional pharmaceutical industry. In this thesis, three spectroscopic PAT tools are investigated, near-infrared-, terahertz-, and fluorescence-spectroscopy. These techniques have been evaluated with chemometrics and theory of sampling. The first study focused on the critical but rather...... overlooked sampling uncertainty that exist in all analytical measurements. The sampling error was studied using an example involving near infrared transmission (NIT) spectroscopy to study content of uniformity of five batches of escitalopram tablets, produced at different active pharmaceutical ingredients...

  17. Distribution of uranium in two sulphide ore environments from the reversed metamorphic sequence of the Daling Rocks in the Dargeeling-Sikkim Himalaya, India

    International Nuclear Information System (INIS)

    Ghosh, A.K.

    1988-01-01

    In the low-grade Daling metasediments of Gorubathan, the average U content of 3-4 ppm reflects the original U content of the unmetamorphosed sediments. The high-grade metasediments of Dichu averag 6 ppm, and the sulphide ores of this area also have more U compared to Gorubathan ores.This higher U content in the high-grade rocks and in the associated ores is believed to be the result of enrichment during metasomatic activity in the area. Neverthelessthe fact that the Daling metasediments have higher U contents thanthat of the sulphide ores appears to be independent of the grade of metamorphism in the progressive sequence

  18. Test af to versioner af Modflow-LGR til simulering af grundvandsstrømninger i områder med begravede dale – syntetisk studie

    DEFF Research Database (Denmark)

    Vilhelmsen, Troels Norvin; Christensen, Steen

    .eks. findes i begravede dale. Manglende opløsning af geologiske aflejringer på lokal skala kan potentielt resultere i fejlagtige prædiktioner af konsekvensen af grundvandsindvinding på kildeplads niveau. For i højere grad at kunne forvalte disse grundvandsressourcerne skal nye metoder undersøges. Dette er...... specielt gældende for komplekse begravede dalsystemer, som interagerer med omkringliggende regionale grundvandsystemer. I dette syntetiske studie er to versioner af MODFLOW - Local Grid Refinment (LGR) testet til simulering af grundvandsstrømninger i områder med begravede dale. Forsøgene er gennemført som...

  19. Decrease of concentrations after 2000 is mainly the result of economic recessions; Daling van concentraties deze eeuw vooral het gevolg van recessies

    Energy Technology Data Exchange (ETDEWEB)

    Cats, G.

    2011-08-15

    The decrease in background concentrations of particulate matter after 2000 is mainly caused by three years of strong decrease, two of which coincided with decreased economic growth. Recessions are an effective source measure and may be necessary for timely compliance with the European standards. [Dutch] De daling in de achtergrondconcentraties van fijn stof na 2000 blijkt vooral terug te voeren tot drie jaren met sterke daling, waarvan er twee samenvielen met verminderde economische groei. Recessies zijn effectief als bronmaatregel en zijn misschien noodzakelijk om tijdig aan de Europese normen te kunnen voldoen.

  20. [The materialistic strategy of Henry Howard, a Québec alienist (1815-1887).].

    Science.gov (United States)

    Fugère, A

    1978-01-01

    At the end of the 19th century, Henry Howard appeared as the first Quebec "aliéniste" to attempt to develop an inclusive theoretical treatise on the question of madness. Why this sudden upheaval ? There existed numerous european theories ; that might have sufficed. The author attempts to show the multiple connections of this theoretical pro-lect to the socio-political problems of québécois society. Howard tries, from the perspective of the theory which he elaborates, to intervene in the major discussions affecting Quebec: ultra montanism, the problem of universal compusory education, public morality. At a more professional level he attempts to intervene in the legal dispute opposing judicial and medical competence in the cases of insanity pleas, as well as in the question of the scientific and social status of the "aliéniste". The involvement in these struggles manifests itself in Howard's treatise as much at the level of the concepts themselves, and their architecture, as at the thematic level and in the applications which he naturally draws. It is not onty external and contingent but works on the text from the inside as well. The article attempts to suggest that at the very moment that the treatise on the alienated-which would become the "science" that we know today- seeks to structure itself into a theory, it cannot break its attachment to its determining social context and that, ignoring its ideological role it, in truth, succeeds only in creating illusion and the impression of a progressive process, all the while being circumstantial and having a verted interest.

  1. Conversations with Howard Shevrin I: Ann Arbor, December 8th, 2004

    OpenAIRE

    Bazan, Ariane

    2010-01-01

    Howard Shevrin is born in 1926 in New York. During World War 2, he is a front line soldier in Germany from December 1944 till February 1945. After the war, he obtains his PhD in psychology and child development at the New York Cornell University. In 1954 he joins the Menninger Foundation in Texas, where he starts doing subliminal research with Lester Luborsky and Charles Fischer. He also completes his analytic training there. In 1973, he joins the University of Michigan as a professor of psyc...

  2. Howard Hughes and the Cold War Aviation Film Jet Pilot (1957

    Directory of Open Access Journals (Sweden)

    Richard Andrew Voeltz

    2016-10-01

    War.  But sexual intimacy, conspicuous consumption, and aviation technology also inserted themselves into the perfect safetly of American domestic bliss. This paper will analyze how the eccentric Cold War romantic comedy Jet Pilot (1957 so associated with the compulsiveness of Howard Hughes, produced and written by Jules Furthman, directed ( partially by Josef von Sternburg and starring John Wayne and Janet Leigh, reflects all these themes making it the paradigmatic Cold Film that remains a camp classic from the American popular cultyre of the 1950s.

  3. A Deceptive Initiation: An Ecological Paradigm in Howard O’Hagan’s Tay John

    Directory of Open Access Journals (Sweden)

    Sergiy Yakovenko

    2017-11-01

    Full Text Available Howard O’Hagan’s novel Tay John has been widely discussed as a modernist work of deconstruction that undermines the established concepts of broadly understood mythology, narrative, and gender. In this article, I focus on one of the previously neglected aspects of the novel’s mythological drama – the clash of the pre-modern and modern ecological epistemai, which unfolds as an originary event of entering into modernity. I argue that the dramatic irony of a recoded indigenous myth introduces the aboriginal Shuswaps to the colonialist perception of the environment, deceptively making them hostages of their own beliefs and thereby drastically changing their temporal-spatial continuum.

  4. Enfermedad diarreica aguda por Escherichia coli patógenas en Colombia

    Science.gov (United States)

    Gómez-Duarte, Oscar G.

    2014-01-01

    Resumen Las cepas de E. coli patógenas intestinales son causas importantes de la enfermedad diarreica aguda (EDA) en niños menores de 5 años en América Latina, África y Asia y están asociadas a alta mortalidad en niños en las comunidades más pobres de África y el Sudeste Asiático. Estudios sobre el papel de las E. coli patógenas intestinales en la EDA infantil en Colombia y otros países de América Latina son limitados debido a la carencia de ensayos para detección de estos patógenos en los laboratorios clínicos de centros de salud. Estudios recientes han reportado la detección de E. coli patógenas intestinales en Colombia, siendo la E. coli enterotoxigénica la cepa más frecuentemente asociada a diarrea en niños menores de 5 años. Otros patógenos detectados en estos pacientes incluyen las E. coli enteroagregativa, enteropatógena, productora de toxina Shiga, y de adherencia difusa. Con base en estudios que reportan la presencia de E. coli productora de toxina Shiga y E. coli enteroagregativa en carnes y vegetales en supermercados, se cree que productos alimentarios contaminados contribuyen a la transmisión de estos patógenos y a la infección del huésped susceptible. Más estudios son necesarios para evaluar los mecanismos de transmisión, el impacto en la epidemiologia de la EDA, y las pautas de manejo y prevención de estos patógenos que afectan la población pediátrica en Colombia. PMID:25491457

  5. Representations of female protagonism in Howards End, by E. M. Forster

    Directory of Open Access Journals (Sweden)

    Alexandre Menezes de Aguiar

    2017-07-01

    Full Text Available E. M. Forster’s feminine characters are very important in his novels as they represent social, political and philosophical aspects of the 20th century society, and through them the author describes his observations about the main events that define the society. In Howards Ends, the Schlegel sisters Margaret, Helen and aunt Juley represent the feminine emancipation and the cultural aspects of bourgeoisie. The sisters’ pathways cross with Ruth Wilcox’s one, Henry’s wife, who assists them in time of hardness when their rent expires deciding to give her house (Howards End to them. Besides them, other important characters as Dolly, Madam Avery, Evie and Jacky Bast are responsible for developing certain activities and representations in the novel. The analysis of their personalities and characteristics provide an objective observation of what E. M. Forster really desires to describe in the 1910s. Then, by uniting these groups of women, we can delimit their specificities and attributions, observing each singularity they have. This approach of the feminine family nucleus provides a sociocultural analysis of the three social classes represented in the novel: economic elite (Wilcox, bourgeoisie (Schlegel and proletariat (Bast at the beginning of the 20th Century.

  6. Public Speaking on the Streets and in the Ivory Tower: A Comparison of the Dale Carnegie Course and the Academic Course.

    Science.gov (United States)

    Miller, Christine M.

    Many speech communication educators and researchers look upon Dale Carnegie's public speaking course with derision for its methods as well as its motives. A comparison of Carnegie's course with university courses in speech communication reveals a number of differences between the two, which in part explains this attitude. Carnegie began his course…

  7. PATs Operating in Water Networks under Unsteady Flow Conditions: Control Valve Manoeuvre and Overspeed Effect

    Directory of Open Access Journals (Sweden)

    Modesto Pérez-Sánchez

    2018-04-01

    Full Text Available The knowledge of transient conditions in water pressurized networks equipped with pump as turbines (PATs is of the utmost importance and necessary for the design and correct implementation of these new renewable solutions. This research characterizes the water hammer phenomenon in the design of PAT systems, emphasizing the transient events that can occur during a normal operation. This is based on project concerns towards a stable and efficient operation associated with the normal dynamic behaviour of flow control valve closure or by the induced overspeed effect. Basic concepts of mathematical modelling, characterization of control valve behaviour, damping effects in the wave propagation and runaway conditions of PATs are currently related to an inadequate design. The precise evaluation of basic operating rules depends upon the system and component type, as well as the required safety level during each operation.

  8. Pit-a-Pat: A Smart Electrocardiogram System for Detecting Arrhythmia.

    Science.gov (United States)

    Park, Juyoung; Lee, Kuyeon; Kang, Kyungtae

    2015-10-01

    Electrocardiogram (ECG) telemonitoring is one of the most promising applications of medical telemetry. However, previous approaches to ECG telemonitoring have largely relied on public databases of ECG results. In this article we propose a smart ECG system called Pit-a-Pat, which extracts features from ECG signals and detects arrhythmia. It is designed to run on an Android™ (Google, Mountain View, CA) device, without requiring modifications to other software. We implemented the Pit-a-Pat system using a commercial ECG device, and the experimental results demonstrate the effectiveness and accuracy of Pit-a-Pat for monitoring the ECG signal and analyzing the cardiac activity of a mobile patient. The proposed system allows monitoring of cardiac activity with automatic analysis, thereby providing a convenient, inexpensive, and ubiquitous adjunct to personal healthcare.

  9. Dale Reed with X-38 and a Subscale Model Used in Test Program

    Science.gov (United States)

    1997-01-01

    Dale Reed, a NASA engineer who worked on the original lifting-body research programs in the 1960s and 1970s, stands with a scale-model X-38 that was used in 1995 research flights, with a full-scale X-38 (80 percent of the size of a potential Crew Return Vehicle) behind him. The X-38 Crew Return Vehicle (CRV) research project is designed to develop the technology for a prototype emergency crew return vehicle, or lifeboat, for the International Space Station. The project is also intended to develop a crew return vehicle design that could be modified for other uses, such as a joint U.S. and international human spacecraft that could be launched on the French Ariane-5 Booster. The X-38 project is using available technology and off-the-shelf equipment to significantly decrease development costs. Original estimates to develop a capsule-type crew return vehicle were estimated at more than $2 billion. X-38 project officials have estimated that development costs for the X-38 concept will be approximately one quarter of the original estimate. Off-the-shelf technology is not necessarily 'old' technology. Many of the technologies being used in the X-38 project have never before been applied to a human-flight spacecraft. For example, the X-38 flight computer is commercial equipment currently used in aircraft and the flight software operating system is a commercial system already in use in many aerospace applications. The video equipment for the X-38 is existing equipment, some of which has already flown on the space shuttle for previous NASA experiments. The X-38's primary navigational equipment, the Inertial Navigation System/Global Positioning System, is a unit already in use on Navy fighters. The X-38 electromechanical actuators come from previous joint NASA, U.S. Air Force, and U.S. Navy research and development projects. Finally, an existing special coating developed by NASA will be used on the X-38 thermal tiles to make them more durable than those used on the space

  10. Assessment of family psychosocial functioning in survivors of pediatric cancer using the PAT2.0.

    Science.gov (United States)

    Gilleland, Jordan; Reed-Knight, Bonney; Brand, Sarah; Griffin, Anya; Wasilewski-Masker, Karen; Meacham, Lillian; Mertens, Ann

    2013-09-01

    This study aimed to examine clinical validity and utility of a screening measure for familial psychosocial risk, the Psychosocial Assessment Tool 2.0 (PAT2.0), among pediatric cancer survivors participating in long-term survivorship care. Caregivers (N=79) completed the PAT2.0 during their child's survivorship appointment. Caregivers also reported on family engagement in outpatient mental health treatment. Medical records were reviewed for treatment history and oncology provider initiated psychology consults. The internal consistency of the PAT2.0 total score in this survivorship sample was strong. Psychology was consulted by the oncology provider to see 53% of participant families, and families seen by psychology had significantly higher PAT2.0 total scores than families without psychology consults. PAT2.0 total scores and corresponding subscales were higher for patients, parents, and siblings enrolled in outpatient mental health services since treatment completion. Results were consistent with psychosocial risk categories presented within the Pediatric Psychosocial Preventative Health Model. Fifty-one percent of families presenting for survivorship care scored in the "universal" category, 34% scored in the "targeted" category, and 15% scored in the "clinical" category. Data indicate that the overall proportions of families experiencing "universal", "targeted", and "clinical" levels of familial distress may be constant from the time of diagnosis into survivorship care. Overall, the PAT2.0 demonstrated strong psychometric properties among survivors of pediatric cancer and shows promise as a psychosocial screening measure to facilitate more effective family support in survivorship care. Copyright © 2013 John Wiley & Sons, Ltd.

  11. The effects of PAT on the Savannah River ecosystem, particularly fisheries

    Energy Technology Data Exchange (ETDEWEB)

    Patrick, R.

    1994-03-01

    The main purpose of this study was to determine whether or not the pre-startup activities at K-Reactor, i.e., Power Ascension Testing (PAT), have caused damage because of temperature rises in the Savannah River. Therefore, the biological studies were mainly aimed at providing information as to changes that might cause the damage of the fish population, and to other important organisms in the ecosystem. To determine if deleterious effects had occurred, one had to review the past studies to determine the condition and diversity of aquatic life before these PAT studies started. Therefore old reports were reviewed and a current study made in 1992.

  12. Crystallization and preliminary X-ray diffraction analysis of PAT, an acetyltransferase from Sulfolobus solfataricus

    International Nuclear Information System (INIS)

    Cho, Ching-Chang; Luo, Ching-Wei; Hsu, Chun-Hua

    2008-01-01

    PAT, an acetyltransferase from the archaeon S. solfataricus that specifically acetylates the chromatin protein Alba, was expressed, purified and crystallized. PAT is an acetyltransferase from the archaeon Sulfolobus solfataricus that specifically acetylates the chromatin protein Alba. The enzyme was expressed, purified and subsequently crystallized using the sitting-drop vapour-diffusion technique. Native diffraction data were collected to 1.70 Å resolution on the BL13C1 beamline of NSRRC from a flash-frozen crystal at 100 K. The crystals belonged to space group P2 1 2 1 2 1 , with unit-cell parameters a = 44.30, b = 46.59, c = 68.39 Å

  13. Mycobacterium chelonae y Mycobacterium abscessus: patógenos emergentes

    Directory of Open Access Journals (Sweden)

    Mónica M. Ortegón

    1996-09-01

    Full Text Available Mycobacterium chelonae es el nombre correcto para la micobacteria aislada en 1903 de los pulmones enfermos de una tortuga marina. En una especie distinta de Mycobacterium fo/tuitum, aislado de ranas en 1905, y de Mycobacterium abscessus, considerado actualmente como una subespecie de M chelonae. Estas tres especies son las únicas patógenas para el hombre dentro del grupo de micobacterias ambientales o atipicas, de crecimiento rápido, las cuales se caracterizan por formar colonias en cultivo en menos de siete días. Son agentes etiológicos de nódulos y abscesos cutáneos, localizados y diseminados, de lesiones postoperatorias, usualmente en la cicatriz quirúrgica, de lesiones pulmonares y de linfadenitis granulomatosa, de osteomielitis y de queratitis, entre otras. Las lesiones cutáneas y de los tejidos blandos son las más frecuentes y resultan generalmente de la inoculación traumática de esta micobacteria. Histopatológicamente, los nódulos y abscesos muestran un proceso inflamatorio, supurativo y granulomatoso, mixto, en el que en la cuarta parte de los casos pueden demostrarse conglomerados de bacilos ácido alcohol resistentes, que tienden a estar situados en una vacuola en el centro del absceso. En Colombia, se han descrito tres brotes de abscesos subcutáneos producidos por bacterias ambientales, secundarios a la aplicación de inyecciones contaminadas con el germen causal: en 1981, en Bucaramanga, luego de la aplicación de la vacuna contra la fiebre amarilla, en 50 personas, la mayoría niños; en 1989, en Medellin, por la inyección subcutánea de alergenos, en 13 personas; y, en 1993, en varias ciudades de la costa atlántica, luego de aplicaciones subcutáneas de xilocaína, como tratamiento bionergético, en 297 pacientes. Existen otros informes aislados de casos posttraumáticos.La enfermedad diseminada por micobacterias de rápido crecimiento, se presenta en pacientes inmunosuprimidos. En la biopsia, predominan los

  14. PAT1 (SLC36A1) shows nuclear localization and affect growth of smooth muscle cells from rats

    DEFF Research Database (Denmark)

    Jensen, Anne; Figueiredo-Larsen, Evan Manuel; Holm, René

    2014-01-01

    The proton-coupled amino acid transporter 1 (PAT1) is a transporter of amino acids in small intestinal enterocytes. PAT1 is, however, also capable of regulating cell growth and sensing the availability of amino acids in other cell types. The aim of the present study was to investigate the localiz...

  15. PENERAPAN TEORI MULTIPLE INTELLIGENCES HOWARD GARDNER DALAM PEMBELAJARAN PENDIDIKAN AGAMA ISLAM

    Directory of Open Access Journals (Sweden)

    Mushollin -

    2009-07-01

    Full Text Available This article is to describe the concept and the theory of Multiple Intelligences developd by Howard Gardner. Furthermore, it tries to explain how they are applied in the classroom in the Islamic education learning. The theory is the development of doubled-intelligences theory stating that human have different intelligences. Gardner argues that human are endowed eight intelligences---linguistic, natural, logic-mathematic, interpersonal, intrapersonal, spatial, musical, and natural. In educational context, Gardner’s theory effects the learning practice in school as well as the parents treatment to the children in the house. In practice, learning is demanded to develop each intelligence and use any kinds of intelligences to measure the students’ intelligence.

  16. Dialogue avec Howard Becker : comment parler de la société ?

    Directory of Open Access Journals (Sweden)

    Jacques Hamel

    2010-12-01

    Full Text Available Il n’est rien de plus intéressant que de lire le résumé d’un livre écrit par son propre auteur, surtout quand ce dernier a pour nom Howard Becker, l’esprit libre et imaginatif de la sociologie américaine. En effet, la densité et la richesse de Comment parler de la société ? – comme de ses autres écrits – peuvent avoir déjoué l’attention des lecteurs et les avoir incités à négliger certaines thèses chères à l’auteur que celui-ci veut mettre en exergue en s’employant à en donner le compte rendu...

  17. Designing Robust Process Analytical Technology (PAT) Systems for Crystallization Processes: A Potassium Dichromate Crystallization Case Study

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan

    2013-01-01

    The objective of this study is to test and validate a Process Analytical Technology (PAT) system design on a potassium dichromate crystallization process in the presence of input uncertainties using uncertainty and sensitivity analysis. To this end a systematic framework for managing uncertaintie...

  18. Mecanismos de defensa en las interacciones planta-patógeno

    DEFF Research Database (Denmark)

    Madriz-Ordeñana, Kenneth

    1998-01-01

    ésto. Las in- teracciones planta-patógeno pueden presentar varios tipos de asociaciones, que dependen en gran parte del contenido genético de cada organismo. La resistencia inducida es una forma de defensa activa que involucra la expresión diferencial de genes y cambios metabólicos que ocurren como...

  19. Teacher's PAT? Multiple-Role Principal-Agent Theory, Education Politics, and Bureaucrat Power

    Science.gov (United States)

    Vanhuysse, Pieter; Sulitzeanu-Kenan, Raanan

    2009-01-01

    This article aims to contribute to current debates about political power and agency relationships in education and other public sectors. In a recent clarion call for a major redirection of political principal-agent theories (PAT), Terry Moe has argued that standard information asymmetries ought no longer to be regarded as the sole foundation of…

  20. Patógenos introducidos al Perú en post larvas de Litopenaeus vannamei importadas

    Directory of Open Access Journals (Sweden)

    Mervin Guevara

    2012-11-01

    Full Text Available El comercio internacional de animales acuáticos es uno de los factores más importantes en la introducción involuntaria de patógenos a una región libre de estos. Los patógenos introducidos han sido causa de enormes pérdidas económicas en organismos bajo cultivo y daños ecológicos en poblaciones silvestres. En este trabajo, utilizando la técnica de la PCR se analizaron postlarvas de Litopenaeus vannamei importadas desde Ecuador para ser utilizada en los cultivos de langostinos en Tumbes. La finalidad fue detectar patógenos como el virus de la mancha blanca (WSV, virus de la cabeza amarilla (YHV, virus de la necrosis hipodérmica y hematopoyética infecciosa (IHHNV, Baculovirus penaei (BP, virus del síndrome de Taura (TSV y la bacteria de la hepatopancreatitis necrotizante (NHPB. Se analizaron 177 muestras de postlarvas en el año 2009 y 274 en el 2010. En el año 2009 se encontraron cuatro patógenos infecciosos en las postlarvas analizadas, siendo más frecuente el IHHNV (9,60%. En el año 2010 la frecuencia de aparición de postlarvas infectadas con IHHNV fue mayor (16,79%. Tanto en el 2009 como en el 2010 se encontraron postlarvas positivas a NHPB, BP y TSV

  1. Evaluation of the EndoPAT as a Tool to Assess Endothelial Function

    Directory of Open Access Journals (Sweden)

    M. Moerland

    2012-01-01

    Endothelial function was stable over a longer period of time in renally impaired patients (coefficient of variation 13%. Endothelial function in renally impaired and type 2 diabetic patients was not decreased compared to healthy volunteers (2.9±1.4 and 1.8±0.3, resp., versus 1.8±0.5, P>0.05. The EndoPAT did not detect an effect of robust interventions on endothelial function in healthy volunteers (glucose load: change from baseline 0.08±0.50, 95% confidence interval −0.44 to 0.60; smoking: change from baseline 0.49±0.92, 95% confidence interval −0.47 to 1.46. This suggests that at present the EndoPAT might not be suitable to assess (changes in endothelial function in early-phase clinical pharmacology studies. Endothelial function as measured by the EndoPAT could be physiologically different from endothelial function as measured by conventional techniques. This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice.

  2. Investigating Trauma in Narrating World War I: A Psychoanalytical Reading of Pat Barker's "Regeneration"

    Science.gov (United States)

    Sadjadi, Bakhtiar; Esmkhani, Farnaz

    2016-01-01

    The present paper seeks to critically read Pat Barker's "Regeneration" in terms of Cathy Caruth's psychoanalytic study of trauma. This analysis attempts to trace the concepts of latency, post-traumatic stress disorders, traumatic memory, and trauma in Barker's novel in order to explore how trauma and history are interrelated in the…

  3. THz spectroscopy: An emerging technology for pharmaceutical development and pharmaceutical Process Analytical Technology (PAT) applications

    Science.gov (United States)

    Wu, Huiquan; Khan, Mansoor

    2012-08-01

    As an emerging technology, THz spectroscopy has gained increasing attention in the pharmaceutical area during the last decade. This attention is due to the fact that (1) it provides a promising alternative approach for in-depth understanding of both intermolecular interaction among pharmaceutical molecules and pharmaceutical product quality attributes; (2) it provides a promising alternative approach for enhanced process understanding of certain pharmaceutical manufacturing processes; and (3) the FDA pharmaceutical quality initiatives, most noticeably, the Process Analytical Technology (PAT) initiative. In this work, the current status and progress made so far on using THz spectroscopy for pharmaceutical development and pharmaceutical PAT applications are reviewed. In the spirit of demonstrating the utility of first principles modeling approach for addressing model validation challenge and reducing unnecessary model validation "burden" for facilitating THz pharmaceutical PAT applications, two scientific case studies based on published THz spectroscopy measurement results are created and discussed. Furthermore, other technical challenges and opportunities associated with adapting THz spectroscopy as a pharmaceutical PAT tool are highlighted.

  4. Design and Fabrication of Cryostat Interface and Electronics for High Performance Antimatter Trap (HI-PAT)

    Science.gov (United States)

    Smith, Gerald A.

    1999-01-01

    Included in Appendix I to this report is a complete set of design and assembly schematics for the high vacuum inner trap assembly, cryostat interfaces and electronic components for the MSFC HI-PAT. Also included in the final report are summaries of vacuum tests, and electronic tests performed upon completion of the assembly.

  5. Comparison of Different Approaches to Predict the Performance of Pumps As Turbines (PATs

    Directory of Open Access Journals (Sweden)

    Mauro Venturini

    2018-04-01

    Full Text Available This paper deals with the comparison of different methods which can be used for the prediction of the performance curves of pumps as turbines (PATs. The considered approaches are four, i.e., one physics-based simulation model (“white box” model, two “gray box” models, which integrate theory on turbomachines with specific data correlations, and one “black box” model. More in detail, the modeling approaches are: (1 a physics-based simulation model developed by the same authors, which includes the equations for estimating head, power, and efficiency and uses loss coefficients and specific parameters; (2 a model developed by Derakhshan and Nourbakhsh, which first predicts the best efficiency point of a PAT and then reconstructs their complete characteristic curves by means of two ad hoc equations; (3 the prediction model developed by Singh and Nestmann, which predicts the complete turbine characteristics based on pump shape and size; (4 an Evolutionary Polynomial Regression model, which represents a data-driven hybrid scheme which can be used for identifying the explicit mathematical relationship between PAT and pump curves. All approaches are applied to literature data, relying on both pump and PAT performance curves of head, power, and efficiency over the entire range of operation. The experimental data were provided by Derakhshan and Nourbakhsh for four different turbomachines, working in both pump and PAT mode with specific speed values in the range 1.53–5.82. This paper provides a quantitative assessment of the predictions made by means of the considered approaches and also analyzes consistency from a physical point of view. Advantages and drawbacks of each method are also analyzed and discussed.

  6. iPat: intelligent prediction and association tool for genomic research.

    Science.gov (United States)

    Chen, Chunpeng James; Zhang, Zhiwu

    2018-06-01

    The ultimate goal of genomic research is to effectively predict phenotypes from genotypes so that medical management can improve human health and molecular breeding can increase agricultural production. Genomic prediction or selection (GS) plays a complementary role to genome-wide association studies (GWAS), which is the primary method to identify genes underlying phenotypes. Unfortunately, most computing tools cannot perform data analyses for both GWAS and GS. Furthermore, the majority of these tools are executed through a command-line interface (CLI), which requires programming skills. Non-programmers struggle to use them efficiently because of the steep learning curves and zero tolerance for data formats and mistakes when inputting keywords and parameters. To address these problems, this study developed a software package, named the Intelligent Prediction and Association Tool (iPat), with a user-friendly graphical user interface. With iPat, GWAS or GS can be performed using a pointing device to simply drag and/or click on graphical elements to specify input data files, choose input parameters and select analytical models. Models available to users include those implemented in third party CLI packages such as GAPIT, PLINK, FarmCPU, BLINK, rrBLUP and BGLR. Users can choose any data format and conduct analyses with any of these packages. File conversions are automatically conducted for specified input data and selected packages. A GWAS-assisted genomic prediction method was implemented to perform genomic prediction using any GWAS method such as FarmCPU. iPat was written in Java for adaptation to multiple operating systems including Windows, Mac and Linux. The iPat executable file, user manual, tutorials and example datasets are freely available at http://zzlab.net/iPat. zhiwu.zhang@wsu.edu.

  7. Temperature profile and water depth data collected from DALE and other platforms using BT and XBT casts in the North / South Pacific Ocean from 09 November 1979 to 25 November 1985 (NODC Accession 8900063)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and water depth data were collected using BT and XBT casts from the DALE and other platforms in the North / South Pacific Ocean. Data were...

  8. AISLAMIENTO Y CARACTERIZACIÓN MORFOLÓGICA DE Rosellinia pepo Pat. EN PLANTAS DE MACADAMIA ISOLATION AND MORPHOLOGICAL CHARACTERIZATION OF Rosellinia pepo Pat. IN MACADAMIA PLANTS

    Directory of Open Access Journals (Sweden)

    Carmen Eliana Realpe Ortiz

    2006-12-01

    Full Text Available El hongo Rosellinia pepo Pat., causante de la llaga estrellada, se considera uno de los principales problemas fitosanitarios de la macadamia por ocasionar la muerte de la planta en su etapa productiva. Debido a que no existe una metodología de aislamiento confiable que asegure la recuperación del hongo con un porcentaje mínimo de contaminación y los estudios relacionados con este patógeno son escasos se planteó una investigación con el fin de perfeccionar una metodología de aislamiento y realizar algunas caracterizaciones morfológicas de este patógeno. La nueva metodología permitió obtener aislamientos con un 91,26% de pureza del hongo. La tasa de crecimiento fue de 4,68 mm día-1. Las colonias son de color blanco y apariencia algodonosa en su inicio, pero a medida que envejece el micelio toma un color café o negro y su apariencia se torna quebradiza. La observación de micelio blanco en forma de estrella en el lado interior del medio sintético permite diferenciarlo de otras especies como R. bunodes. Las mediciones microscópicas de los hinchamientos piriformes presentaron en promedio 106,4mm de largo y 75,3mm de ancho. Este trabajo también permitió determinar el nivel de inóculo infectivo.The fungus Rosellinia pepo Pat, the causal agent of star gall, is considered to be a main phytosanitary problem to the Macademia tree by causing the death of the tree while in its productive stage. Because no reliable isolation method exists that assures recovery of the mushroom with a minimum percentage of contamination and studies of this pathogen are scarce. This study was conducted to perfect an isolation methodology and permit some morphological characterizations of this pathogen. The new methodology allowed isolations with 91,26% purity of mushroom to be obtained. The rate of growth was 4,68 mm day-1. The colonies were of white color and cottony appearance in the beginning, but as the micelio aged it assumed a brown or black color and a

  9. Science Fiction and the Risks of the Anthropocene: Anticipated Transformations in Dale Pendell’s The Great Bay

    Directory of Open Access Journals (Sweden)

    Weik von Mossner, Alexa

    2014-11-01

    Full Text Available Covering the time span from 2021 to 16000 N.C., Dale Pendell’s speculative novel The Great Bay chronicles the profound climatic, geological and ecological transformations that California undergoes during these fourteen millennia. Human life becomes unimaginably small on such a time scale, and Pendell responds to that representational challenge by compiling a wide variety of texts that zero in on individual humans at different points in the future rather than offering a continuous story or central character. In a way, that place is taken by the geographical region that is the focus of the narrative and gives the book its title. Timothy Morton has argued that because we live in the Anthropocene we can no longer understand history as exclusively human. Pendell’s “Chronicle of the Collapse” suggests that the same is true for storytelling, offering readers the story of a nonhuman protagonist that changes slowly over time. The result is a highly fragmented narrative that is interesting for what it tries to achieve but at the same time remarkably unengaging. In its distant and distanced rendering of future ecological change and human anguish, The Great Bay is a grave reminder not only of the incalculable risks of the Anthropocene, but also of the basic tenets of realist storytelling.

  10. Profile and bioconcentration of minerals by King Bolete (Boletus edulis) from the Płocka Dale in Poland.

    Science.gov (United States)

    Frankowska, Aneta; Ziółkowska, Joanna; Bielawski, Leszek; Falandysz, Jerzy

    2010-01-01

    This study aimed to provide basic data on the composition of metallic elements, including toxicologically important Cd and Hg, in popular and prized wild King Bolete mushrooms. We investigated the importance of soil substratum as a source of these metals. ICP-OES and CV-AAS were applied to determine the profile of Al, Ba, Ca, Cd, Cu, Fe, Hg, K, Mg, Mn, Na, Sr and Zn in caps and stipes of King Bolete mushroom and in the surface layer of soil (0-10 cm) from the Płocka Dale area of Poland. Hg, Cu, Cd, Zn, Mg and K exhibited bioconcentration factors (BCF) > 1. Specifically, Hg, Cu and Cd (mean BCFs for caps were 110, 19 and 16, respectively) were efficiently bioconcentrated by King Bolete, while other elements were bioexcluded (BCF < 1). Cadmium was present in the caps at mean levels of 5.5 ± 2.4 mg kg(-1) dry weight (dw) and mercury at levels of 4.9 ± 1.4 mg kg(-1) dw, both occurring at elevated concentrations in those King Bolete mushrooms surveyed.

  11. The UK-DALE dataset, domestic appliance-level electricity demand and whole-house demand from five UK homes

    Science.gov (United States)

    Kelly, Jack; Knottenbelt, William

    2015-03-01

    Many countries are rolling out smart electricity meters. These measure a home’s total power demand. However, research into consumer behaviour suggests that consumers are best able to improve their energy efficiency when provided with itemised, appliance-by-appliance consumption information. Energy disaggregation is a computational technique for estimating appliance-by-appliance energy consumption from a whole-house meter signal. To conduct research on disaggregation algorithms, researchers require data describing not just the aggregate demand per building but also the ‘ground truth’ demand of individual appliances. In this context, we present UK-DALE: an open-access dataset from the UK recording Domestic Appliance-Level Electricity at a sample rate of 16 kHz for the whole-house and at 1/6 Hz for individual appliances. This is the first open access UK dataset at this temporal resolution. We recorded from five houses, one of which was recorded for 655 days, the longest duration we are aware of for any energy dataset at this sample rate. We also describe the low-cost, open-source, wireless system we built for collecting our dataset.

  12. A Japanese-American Sam Spade: The Metaphysical Detective in Death in Little Tokyo, by Dale Furutani

    Directory of Open Access Journals (Sweden)

    Portilho Carla

    2017-06-01

    Full Text Available The aim of this essay is to discuss the legacy of the roman noir in contemporary detective fiction produced outside the hegemonic center of power, here represented by the novel Death in Little Tokyo (1996, written by Japanese-American author Dale Furutani. Starting from the concept of the metaphysical detective (Haycraft 76; Holquist 153-156, characterized by deep questioning about narrative, interpretation, subjectivity, the nature of reality and the limits of knowledge, this article proposes a discussion about how these literary works, which at first sight represent a traditionally Anglo-American genre, constitute narratives that aim to rescue the memory, history and culture of marginalized communities. Typical of late modernity detective fiction, the metaphysical detective has none of the positivistic detective’s certainties, as he does not share in his Cartesian notion of totality, being presented instead as a successor of the hardboiled detective of the roman noir. In this article I intend to analyze the paths chosen by the author and discuss how his re-reading of the roman noir dialogues with the texts of hegemonic noire detective fiction, inscribing them in literary tradition and subverting them at the same time.

  13. The UK-DALE dataset, domestic appliance-level electricity demand and whole-house demand from five UK homes.

    Science.gov (United States)

    Kelly, Jack; Knottenbelt, William

    2015-01-01

    Many countries are rolling out smart electricity meters. These measure a home's total power demand. However, research into consumer behaviour suggests that consumers are best able to improve their energy efficiency when provided with itemised, appliance-by-appliance consumption information. Energy disaggregation is a computational technique for estimating appliance-by-appliance energy consumption from a whole-house meter signal. To conduct research on disaggregation algorithms, researchers require data describing not just the aggregate demand per building but also the 'ground truth' demand of individual appliances. In this context, we present UK-DALE: an open-access dataset from the UK recording Domestic Appliance-Level Electricity at a sample rate of 16 kHz for the whole-house and at 1/6 Hz for individual appliances. This is the first open access UK dataset at this temporal resolution. We recorded from five houses, one of which was recorded for 655 days, the longest duration we are aware of for any energy dataset at this sample rate. We also describe the low-cost, open-source, wireless system we built for collecting our dataset.

  14. PAT-2 (Plutonium Air-Transportable Model 2) safety analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, J.A.; Davis, E.J.; Duffey, T.A.; Dupree, S.A.; George, O.L. Jr.; Ortiz, Z.

    1981-07-01

    The PAT-2 package is designed for the safe transport of plutonium and/or uranium in small quantities. The PAT-2 package is resistant to severe accidents, including that of a high-speed jet aircraft crash, and is designed to withstand such environments as extreme impact, crushing, puncturing and slashing loads, severe hydrocarbon-fueled fires, and deep underwater immersion, with no escape of contents. The package meets the requirements of 10 CFR 71 for Fissile Class I packages with a cargo of 15 grams of Pu-239, or other isotopic forms described herein, not to exceed 2 watts of thermal activity. This SAR presents design and oprational information including evaluations and analyses, test results, operating procedures, maintenance, and quality assurance information.

  15. PAT-2 (Plutonium Air-Transportable Model 2) safety analysis report

    International Nuclear Information System (INIS)

    Andersen, J.A.; Davis, E.J.; Duffey, T.A.; Dupree, S.A.; George, O.L. Jr.; Ortiz, Z.

    1981-07-01

    The PAT-2 package is designed for the safe transport of plutonium and/or uranium in small quantities. The PAT-2 package is resistant to severe accidents, including that of a high-speed jet aircraft crash, and is designed to withstand such environments as extreme impact, crushing, puncturing and slashing loads, severe hydrocarbon-fueled fires, and deep underwater immersion, with no escape of contents. The package meets the requirements of 10 CFR 71 for Fissile Class I packages with a cargo of 15 grams of Pu-239, or other isotopic forms described herein, not to exceed 2 watts of thermal activity. This SAR presents design and oprational information including evaluations and analyses, test results, operating procedures, maintenance, and quality assurance information

  16. PAT and SEM study of porous silicon formed by anodization methods

    International Nuclear Information System (INIS)

    Liu Jian; Wei Long; Wang Huiyao; Ma Chuangxin; Wang Baoyi

    2000-01-01

    The porous silicon formed by anodization of crystal silicon was studied by positron annihilation technique (PAT) and scanning electron microscopy (SEM). The PAT experiments showed that the mean life and vacancy defects increased with the increasing anodization time. While the intensities of the longest lifetime, several ns-tens ns (ortho-positronium) dropped down. Small single-crystal Si spheres with mean radius of a few μm were observed by SEM after anodization. Pits with mean radius of a few μm from the divorcement of single-crystal spheres were also observed after further anodization. The increases of vacancy defects might be that the extension of structures of porous silicon towards inner layer with anodization time and caused more vacancy defects in inner layer. The SEM observation presented another possibility of the increase of density of vacancy defects in surface layer induced by the change of structures

  17. 2002 Report to Congress: Evaluating the Consensus Best Practices Developed through the Howard Hughes Medical Institute’s Collaborative Hazardous Waste Management Demonstration Project

    Science.gov (United States)

    This report discusses a collaborative project initiated by the Howard Hughes Medical Institute (HHMI) to establish and evaluate a performance-based approach to management of hazardous wastes in the laboratories of academic research institutions.

  18. From heresy to dogma in accounts of opposition to Howard Temin's DNA provirus hypothesis.

    Science.gov (United States)

    Marcum, James A

    2002-01-01

    In 1964 the Wisconsin virologist Howard Temin proposed the DNA provirus hypothesis to explain the mechanism by which a cancer-producing virus containing only RNA infects and transforms cells. His hypothesis reversed the flow of genetic information, as ordained by the central dogma of molecular biology. Although there was initial opposition to his hypothesis it was widely accepted, after the discovery of reverse transcriptase in 1970. Most accounts of Temin's hypothesis after the discovery portray the hypothesis as heretical, because it challenged the central dogma. Temin himself in his Nobel Prize speech of 1975 narrates a similar story about its reception. But are these accounts warranted? I argue that members of the virology community opposed Temin's provirus hypothesis not simply because it was a counterexample to the central dogma, but more importantly because his experimental evidence for supporting it was inconclusive. Furthermore, I propose that these accounts of opposition to the DNA provirus hypothesis as heretical, written by Temin and others after the discovery of reverse transcriptase, played a significant role in establishing retrovirology as a specialized field.

  19. The Disciplined Mind. Howard Gardner. New York, NY: Simon and Schuster Inc., 1999.

    Directory of Open Access Journals (Sweden)

    Ted McKelgan

    1999-01-01

    Full Text Available What is true, beautiful, and good? Using the theory of evolution, the musical genius of Mozart, and the horrors of the Holocaust, Howard Gardner, in The Disciplined Mind successfully assists students' and teachers' cultural understanding of their educational process as it relates to truth, beauty, and goodness. He does this by emphasizing that we should teach less but in more depth. By probing important issues in depth, we will be teaching much more. In pursuit of truth, Gardner links Darwin's development of systematic classification of living organisms to the understanding of topics that effect human beings today. In doing so, he manages to fmd common ground between the scientific and religious communities, despite the controversies surrounding the theory of evolution. He uses the power of music to depict the human condition in Mozart's work, "The Marriage of Figaro," in search of beauty as it appears in music and human relations. And, in pursuit of the good (and the ugly, Gardner uses the Holocaust and the atrocities associated with it, as a way to understand, not only the Holocaust, but also the human motivation behind such a horrific and elaborate endeavour

  20. Ways of Telling About Society. Howard S. Becker in Conversation With Reiner Keller

    Directory of Open Access Journals (Sweden)

    Howard S. Becker

    2016-04-01

    Full Text Available In the following conversation, Howard S. BECKER talks about his lifelong travel with and between sociology and jazz music, his professional training as a sociologist, the hazards of a career, and his involvement with photography and performance. He reflects on the different ways used by artists and sociologists to tell solid stories about social phenomena, and tells a compelling account in its own right about the methodology of sound sociological field work and case study research. By explaining core concepts of his sociological perspective (such as the concept of labeling and "doing things together" and referring to concrete research examples, BECKER in all modesty fully engages with what could be called today's sociological imagination, leaving narrow disciplinary constraints behind in order to explore society with curiosity, using methodologically sensible but nevertheless refreshing approaches. The audio file is accessible from http://dx.doi.org/10.5281/zenodo.49829. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1602122

  1. 'Dale': an interpretative phenomenological analysis of a service user's experience with a crisis resolution/home treatment team in the United Kingdom.

    Science.gov (United States)

    Nelson, L J; Miller, P K; Ashman, D

    2016-08-01

    WHAT IS KNOWN ABOUT THE SUBJECT?: This paper describes crisis resolution/home treatment (CRHT) teams, which are part of mental health services in the United Kingdom. CRHT is expected to assist individuals in building resilience and work within a recovery approach. WHAT THIS PAPER ADDS TO EXISTING KNOWLEDGE?: This paper arises from an interview with one individual, Dale, as part of a larger study exploring service users' experiences of CRHT. It adds to the body of narrative knowledge in CRHT through Dale's co-authorship of this paper, reflecting on his original interview 4 years later, with co-authors providing critical interpretation of his experience, in turn supported by cognate literature. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Implications for practice are considered, themselves mediated through Dale's own descriptions of how CRHT interventions impacted upon him. These impacts are analysed with respect to three themes: Resilience, Recovery and Power. It is centrally contended that clinicians need to more clearly comprehend three core matters. First, what resilience 'is' for service users as well as the complex process through which these individuals move in developing resilience. Second, the distinction that service users might make between 'recovery' and 'functionality', and how this in turn can impact on individuals both in personal and socioeconomic sense. Finally, the mechanics of power within CRHT contexts and how these interpersonal dynamics can affect the relationship between service user and clinician in practice. Introduction and Aim The central purpose of this paper, part of a larger study exploring the experiences of Service Users (SUs) with CRHT, is to emphasise the importance of the SU voice itself within the domain. Following an interrogation of the historical contexts of CRHT. Method This paper uses interpretative phenomological approach around detailed thematic examination of an extended, semi-structured with a single SU: Dale. Moreover, four

  2. Pump Application as Hydraulic Turbine – Pump as Turbine (PaT)

    OpenAIRE

    Rusovs, D

    2009-01-01

    The paper considers pump operation as hydraulic turbine with purpose to produce mechanical power from liquid flow. The Francis hydraulic turbine was selected for comparison with centrifugal pump in reverse operation. Turbine and centrifugal pump velocity triangles were considered with purpose to evaluate PaT efficiency. Shape of impeller blades for turbine and pumps was analysed. Specific speed calculation is carried out with purpose to obtain similarity in pump and turbine description. For ...

  3. Quantifying Beetle-Mediated Effects on Gas Fluxes from Dung Pats

    Science.gov (United States)

    Penttilä, Atte; Slade, Eleanor M.; Simojoki, Asko; Riutta, Terhi; Minkkinen, Kari; Roslin, Tomas

    2013-01-01

    Agriculture is one of the largest contributors of the anthropogenic greenhouse gases (GHGs) responsible for global warming. Measurements of gas fluxes from dung pats suggest that dung is a source of GHGs, but whether these emissions are modified by arthropods has not been studied. A closed chamber system was used to measure the fluxes of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) from dung pats with and without dung beetles on a grass sward. The presence of dung beetles significantly affected the fluxes of GHGs from dung pats. Most importantly, fresh dung pats emitted higher amounts of CO2 and lower amounts of CH4 per day in the presence than absence of beetles. Emissions of N2O showed a distinct peak three weeks after the start of the experiment – a pattern detected only in the presence of beetles. When summed over the main grazing season (June–July), total emissions of CH4 proved significantly lower, and total emissions of N2O significantly higher in the presence than absence of beetles. While clearly conditional on the experimental conditions, the patterns observed here reveal a potential impact of dung beetles on gas fluxes realized at a small spatial scale, and thereby suggest that arthropods may have an overall effect on gas fluxes from agriculture. Dissecting the exact mechanisms behind these effects, mapping out the range of conditions under which they occur, and quantifying effect sizes under variable environmental conditions emerge as key priorities for further research. PMID:23940758

  4. X-PAT: a multiplatform patient referral data management system for small healthcare institution requirements.

    Science.gov (United States)

    Masseroli, Marco; Marchente, Mario

    2008-07-01

    We present X-PAT, a platform-independent software prototype that is able to manage patient referral multimedia data in an intranet network scenario according to the specific control procedures of a healthcare institution. It is a self-developed storage framework based on a file system, implemented in eXtensible Markup Language (XML) and PHP Hypertext Preprocessor Language, and addressed to the requirements of limited-dimension healthcare entities (small hospitals, private medical centers, outpatient clinics, and laboratories). In X-PAT, healthcare data descriptions, stored in a novel Referral Base Management System (RBMS) according to Health Level 7 Clinical Document Architecture Release 2 (CDA R2) standard, can be easily applied to the specific data and organizational procedures of a particular healthcare working environment thanks also to the use of standard clinical terminology. Managed data, centralized on a server, are structured in the RBMS schema using a flexible patient record and CDA healthcare referral document structures based on XML technology. A novel search engine allows defining and performing queries on stored data, whose rapid execution is ensured by expandable RBMS indexing structures. Healthcare personnel can interface the X-PAT system, according to applied state-of-the-art privacy and security measures, through friendly and intuitive Web pages that facilitate user acceptance.

  5. El sistema ubicuitina/proteasoma en la interacción planta-patógeno

    Directory of Open Access Journals (Sweden)

    Mario Rocha-Sosa

    2013-01-01

    Full Text Available La ubicuitina (Ub es una proteína pequeña la cual es utilizada por los organismos eucariontes para marcar proteínas, en la mayoría de los casos para que éstas sean posteriormente degradadas. La ubicuitinación ocurre en tres pasos sucesivos los cuales requieren de la acción de una enzima activadora, una enzima conjugadora y una ligasa de Ub. Una vez ubicuitinada la proteína seguirá un destino diferente de acuerdo a la topología de la ubicuitinación. Muchas de las proteínas marcadas por ubicuitinación serán degradadas por un complejo proteínico de 2.5 Mda conocido como el proteasoma 26S. Las plantas emplean ampliamente este mecanismo de degradación regulada de proteínas para modular procesos de crecimiento y desarrollo o bien, para responder ante situaciones adversas como puede ser una baja disponibilidad de agua o el ataque por patógenos. Durante la evolución las plantas han desarrollado diversas estrategias para defenderse ante la agresión por patógenos, sin embargo, estos organismos han logrado implementar herramientas que les permiten contrarrestar los mecanismos de defensa de las plantas, entre otras formas, los patógenos han logrado manipular el sistema Ub/proteasoma para poder infectarlas eficientemente.

  6. Patērētāju attieksme pret zīmolu "IKEA"

    OpenAIRE

    Aleksejenko, Dana

    2014-01-01

    Tēma ir “Patērētāju attieksme pret zīmolu “IKEA””.Pētījuma mērķis ir noskaidrot Latvijas iedzīvotāju, “IKEA” zīmola patērētāju un mazumtirgotāju viedokli, attieksmi un vērtējumu par zīmolu “IKEA”.Radošā daļa ir pamatota ar teorētisko daļu par:zīmola jēdzienu, patērētāju uzvedību, mārketinga komunikāciju un uzņēmumu internetā. Apakašnodaļās ir aprakstīta zīmola identitāte un zīmola vērtība, korporatīvais zīmols un korporatīvā identitāte.Metodoloģija ir izstrādāta vairākās pakāpēs,katras pakāpe...

  7. Ion Storage Tests with the High Performance Antimatter Trap (HiPAT)

    Science.gov (United States)

    Martin, James J.; Lewis, Raymond A.; Chakrabarti, Suman; Pearson, Boise; Schafer, Charles (Technical Monitor)

    2002-01-01

    The NASA/Marshall Space Flight Centers (NASA/MSFC) Propulsion Research Center (PRC) is evaluating an antiproton storage system, referred to as the High Performance Antiproton Trap (HiPAT). This interest stems from the sheer energy represented by matter/antimatter annihilation process with has an energy density approximately 10 order of magnitude above that of chemical propellants. In other terms, one gram of antiprotons contains the equivalent energy of approximately 23 space shuttle external tanks or ET's (each ET contains roughly 740,000 kgs of fuel and oxidizer). This incredible source of stored energy, if harnessed, would be an enabling technology for deep space mission where both spacecraft weight and propulsion performance are key to satisfying aggressive mission requirements. The HiPAT hardware consists of a 4 Tesla superconductor system, an ultra high vacuum test section (vacuum approaching 10(exp -12) torr), and a high voltage confinement electrode system (up to 20 kvolts operation). The current laboratory layout is illustrated. The HiPAT designed objectives included storage of up to 1 trillion antiprotons with corresponding lifetimes approaching 18 days. To date, testing has centered on the storage of positive hydrogen ions produced in situ by a stream of high-energy electrons that passes through the trapping region. However, due to space charge issues and electron beam compression as it passes through the HiPAT central field, current ion production is limited to less then 50,000 ions. Ion lifetime was determined by counting particle populations at the end of various storage time intervals. Particle detection was accomplished by destructively expelling the ions against a micro-channel plate located just outside the traps magnetic field. The effect of radio frequency (RF) stabilization on the lifetime of trapped particles was also examined. This technique, referred to as a rotating wall, made use of a segmented electrode located near the center of the trap

  8. Expression of PAT and NPT II proteins during the developmental stages of a genetically modified pepper developed in Korea.

    Science.gov (United States)

    Kim, Hyo Jin; Lee, Si Myung; Kim, Jae Kwang; Ryu, Tae Hun; Suh, Seok Cheol; Cho, Hyun Suk

    2010-10-27

    Estimation of the protein levels introduced in a biotechnology-derived product is conducted as part of an overall safety assessment. An enzyme-linked immunosorbent assay (ELISA) was used to analyze phosphinothricin acetyltransferase (PAT) and neomycin phosphotransferase II (NPT II) protein expression in a genetically modified (GM) pepper plant developed in Korea. PAT and NPT II expression levels, based on both dry weight and fresh weight, were variable among different plant generations and plant sections from isolated genetically modified organism (GMO) fields at four developmental stages. PAT expression was highest in leaves at anthesis (11.44 μg/gdw and 2.17 μg/gfw) and lowest in roots (0.12 μg/gdw and 0.01 μg/gfw). NPT II expression was also highest in leaves at anthesis (17.31 μg/gdw and 3.41 μg/gfw) and lowest in red pepper (0.65 μg/gdw and 0.12 μg/gfw). In pollen, PAT expression was 0.59-0.62 μg/gdw, while NPT II was not detected. Both PAT and NPT II showed a general pattern of decreased expression with progression of the growing season. As expected, PAT and NPT II protein expression was not detectable in control pepper plants.

  9. Uranium hydrogeochemical and stream sediment reconnaissance of the Howard Pass NTMS quadrangle, Alaska

    International Nuclear Information System (INIS)

    1982-01-01

    This report presents results of a Hydrogeochemical and Stream Sediment Reconnaissance (HSSR) of the Howard Pass NTMS quadrangle, Alaska. In addition to this abbreviated data release, more complete data are available to the public in machine-readable form. These machine-readable data, as well as quarterly or semiannual program progress reports containing further information on the HSSR program in general, or on the Los Alamos National Laboratory (LANL) portion of the program in particular, are available from DOE's Technical Library at its Grand Junction Area Office. Presented in this data release are location data, field analysis, and laboratory analyses of several different sample media. For the sake of brevity, many field site observations have not been included in this volume; these data are, however, available on the magnetic tape. Appendices A and B describe the sample media and summarize the analytical results for each medium. The data have been subdivided by one of the Los Alamos National Laboratory sorting programs of Zinkl and others (1981a) into groups of stream-sediment and lake-sediment samples. For each group which contains a sufficient number of observations, statistical tables, tables of raw data, and 1:1,000,000 scale maps of pertinent elements have been included in this report. Also included are maps showing results of multivariate statistical analyses. Information on the field and analytical procedures used by the Los Alamos National Laboratory during sample collection and analysis may be found in any HSSR data release prepared by the Laboratory and will not be included in this report

  10. Microorganismos patógenos y potencialmente patógenos en secreciones genitales de gestantes a término asociados a complicaciones posnatales

    Directory of Open Access Journals (Sweden)

    Tania Castellanos Medina

    2013-09-01

    Full Text Available Introducción: tanto las infecciones puerperales como las neonatales precoces reflejan probablemente los microorganismos que están presentes en la vagina en el período cercano al parto. Objetivo: establecer la relación entre los microorganismos identificados en las secreciones genitales de las gestantes a término y el desarrollo de sepsis neonatal y puerperal, así como vincular dichas complicaciones con los agentes diagnosticados. Métodos: se realizó un estudio longitudinal y prospectivo en los servicios de microbiología, obstetricia, perinatología y neonatología del Hospital General Docente "Dr. "Juan Bruno Zayas Alfonso", de Santiago de Cuba, desde julio de 2009 hasta marzo de 2010. Se identificaron microorganismos en 179 muestras cervicovaginales, las cuales fueron procesadas en el laboratorio de microbiología según las normas vigentes. Resultados: los microorganismos más identificados resultaron los géneros Mycoplasmas y Chlamydias (78,2 y 69,3%, respectivamente y fueron los que con mayor frecuencia se asociaron. Un porcentaje elevado de las gestantes (67,0 %, tenía más de un agente en sus secreciones genitales. Después del parto hubo un hallazgo mayor de infecciones en el producto de la concepción (21,8 % que en las puérperas (3,9% y la mayoría de estas complicaciones se relacionaron con la presencia de 2 o más microorganismos. Conclusiones: las asociaciones de microorganismos patógenos o potencialmente patógenos en las secreciones genitales de embarazadas a término, aumentan el riesgo de complicaciones posnatales.

  11. Greenhouse gas emissions from dung pats vary with dung beetle species and with assemblage composition.

    Directory of Open Access Journals (Sweden)

    Irene Piccini

    Full Text Available Cattle farming is a major source of greenhouse gases (GHGs. Recent research suggests that GHG fluxes from dung pats could be affected by biotic interactions involving dung beetles. Whether and how these effects vary among beetle species and with assemblage composition is yet to be established. To examine the link between GHGs and different dung beetle species assemblages, we used a closed chamber system to measure fluxes of carbon dioxide (CO2, methane (CH4 and nitrous oxide (N2O from cattle dung pats. Targeting a total of four dung beetle species (a pat-dwelling species, a roller of dung balls, a large and a small tunnelling species, we ran six experimental treatments (four monospecific and two mixed and two controls (one with dung but without beetles, and one with neither dung nor beetles. In this setting, the overall presence of beetles significantly affected the gas fluxes, but different species contributed unequally to GHG emissions. When compared to the control with dung, we detected an overall reduction in the total cumulative CO2 flux from all treatments with beetles and a reduction in N2O flux from the treatments with the three most abundant dung beetle species. These reductions can be seen as beneficial ecosystem services. Nonetheless, we also observed a disservice provided by the large tunneler, Copris lunaris, which significantly increased the CH4 flux-an effect potentially traceable to the species' nesting strategy involving the construction of large brood balls. When fluxes were summed into CO2-equivalents across individual GHG compounds, dung with beetles proved to emit less GHGs than did beetle-free dung, with the mix of the three most abundant species providing the highest reduction (-32%. As the mix of multiple species proved the most effective in reducing CO2-equivalents, the conservation of diverse assemblages of dung beetles emerges as a priority in agro-pastoral ecosystems.

  12. Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Kylie D Swisher

    Full Text Available In Saccharomyces cerevisiae, mRNA transcripts with premature termination codons are targeted for deadenylation independent decapping and 5' to 3' decay in a quality control pathway termed nonsense-mediated decay (NMD. Critical factors in NMD include Upf1, Upf2, and Upf3, as well as the decapping enzyme, Dcp2/Dcp1. Loss of Upf2 or Upf3 leads to the accumulation of not only Upf1 and Dcp2 in P-bodies, but also of the decapping-activators Pat1, Dhh1, and Lsm1. An interaction between Upf1 and Dcp2 has been identified, which might recruit Dcp2 to the NMD decapping complex. To determine the nature and significance of the Dcp2-Upf1 interaction, we utilized the yeast two-hybrid assay to assess Upf1 interactions with various mRNA decapping factors. We find that although Dcp2 can interact with Upf1, this interaction is indirect and is largely dependent on the Edc3 protein, which interacts with the N-terminal domain of Upf1 at an overlapping, but not identical, site as Upf2. We also found that Pat1 has an independent two-hybrid interaction with the N-terminus of Upf1. Assessment of both reporter and endogenous NMD transcripts suggest that the decapping stimulators, including Edc3 and Pat1, as well as Edc1 and Edc2, are not essential for NMD under normal conditions. This work defines a larger decapping complex involved in NMD, but indicates that components of that complex are not required for general NMD and might either regulate a subset of NMD transcripts or be essential for proper NMD under different environmental conditions.

  13. Cobre antimicrobiano contra patógenos intrahospitalarios en Perú

    Directory of Open Access Journals (Sweden)

    Edwin Neciosup

    2015-01-01

    Full Text Available Introducción: Las infecciones intrahospitalarias (IIH constituyen un problema de salud pública que generan grandes gastos por parte de los gobiernos, debido a que los patógenos causantes de IIH presentan resistencia a fármacos y generan una mayor permanencia de los pacientes, pues la infraestructura hospitalaria constituye un reservorio favorable para los patógenos. Las superficies de cobre surgen como opción sanitaria y efectiva para controlar el crecimiento y propagación de estos patógenos. Objetivos: Evaluar la actividad bactericida de las superficies de cobre contra los principales bacterias patógenas causantes de IIH (Escherichia coli, Pseudomonas aeruginosa y Staphylococcus aureus. Diseño: Estudio experimental con muestreo no probabilístico. Lugar: Hospital Regional Docente las Mercedes (HRDLM y Hospital Provincial Docente Belén (HPDB, Lambayeque, Perú. Materiales: Nueve cepas bacterianas, 3 de E. coli , 3 de P. aeruginosa y 3 de S. aureus; superficies metálicas (1 cm² de cobre y acero inoxidable (control . Intervenciones: Las 9 cepas bacterianas fueron proporcionadas por los hospitales HRDLM (4 cepas y HPDB (5 cepas. Los análisis de ANOVA y de Tukey fueron aplicados para evaluar la actividad bactericida de las superficies de cobre y acero inoxidable contra las 9 cepas causantes de IIH, usando los programas estadísticos Minitab y Sigmaplot, respectivamente. Principales medidas de resultados: Diferencias en el crecimiento bacteriano sobre superficies de cobre o acero inoxidable, con respecto al tiempo de exposición. Resultados: Las 9 cepas -3 de P. aeruginosa, 3 de E. coli y 3 de S. aureus - expuestas a superficies de cobre fueron eliminadas en 10, 15 y 60 minutos, respectivamente. La carga bacteriana de las células expuestas en superficies de acero inoxidable permaneció constante y viable por periodos mayores a 60 minutos. Además, las superficies de cobre eliminaron más rápido a las bacterias Gram negativas (P

  14. NeuPAT: an intranet database supporting translational research in neuroblastic tumors.

    Science.gov (United States)

    Villamón, Eva; Piqueras, Marta; Meseguer, Javier; Blanquer, Ignacio; Berbegall, Ana P; Tadeo, Irene; Hernández, Vicente; Navarro, Samuel; Noguera, Rosa

    2013-03-01

    Translational research in oncology is directed mainly towards establishing a better risk stratification and searching for appropriate therapeutic targets. This research generates a tremendous amount of complex clinical and biological data needing speedy and effective management. The authors describe the design, implementation and early experiences of a computer-aided system for the integration and management of data for neuroblastoma patients. NeuPAT facilitates clinical and translational research, minimizes the workload in consolidating the information, reduces errors and increases correlation of data through extensive coding. This design can also be applied to other tumor types. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. The Killer Will Remain Free: On Pat Parker and the Poetics of Madness.

    Science.gov (United States)

    Ali, Kazim

    2015-01-01

    Poet and scholar Kazim Ali reads Pat Parker's Movement in Black intimately, one poet to another, uncovering the shadow-fact of the lives of most people of color: not only the anger that is somehow sublimated into every part of our lives but also the issue that carrying this feeling around has on our mental health itself-that "anger" and "madness" might have sources in one another. Ali concludes that Parker offers a brutal and clear-eyed and ultimately hopeful assessment of the conditions that were faced at the time, and even now, by communities of color.

  16. Process synthesis for natural products from plants based on PAT methodology

    DEFF Research Database (Denmark)

    Malwade, Chandrakant Ramkrishna; Qu, Haiyan; Rong, Ben-Guang

    2017-01-01

    (QbD) approach, has been included at various steps to obtain molecular level information of process streams and thereby, support the rational decision making. The formulated methodology has been used to isolate and purify artemisinin, an antimalarial drug, from dried leaves of the plant Artemisia...... generates different process flowsheet alternatives consisting of multiple separation techniques. Decision making is supported by heuristics as well as basic process information already available from previous studies. In addition, process analytical technology (PAT) framework, a part of Quality by Design...

  17. 100th anniversary of the death of Ricketts: Howard Taylor Ricketts (1871-1910). The namesake of the Rickettsiaceae family.

    Science.gov (United States)

    Gross, Dominik; Schäfer, Gereon

    2011-01-01

    The US American pathologist and microbiologist Howard Taylor Ricketts died 100 years ago. He is renowned for discovering the causative organism and the transmission route of Rocky Mountain spotted fever and of tabardillo--an epidemic louse-borne typhus occurring especially in Mexico. He also found that both diseases were caused by related infectious agents (Rickettsia rickettsii and Rickettsia prowazekii). The scientific community therefore named both a taxonomic family (Rickettsiaceae) and an order (Rickettsiales) after the scientist. Ricketts' work on immunity and serums became the basis for further advances in vaccine development. Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

  18. Toward Higher QA: From Parametric Release of Sterile Parenteral Products to PAT for Other Pharmaceutical Dosage Forms.

    Science.gov (United States)

    Hock, Sia Chong; Constance, Neo Xue Rui; Wah, Chan Lai

    2012-01-01

    Pharmaceutical products are generally subjected to end-product batch testing as a means of quality control. Due to the inherent limitations of conventional batch testing, this is not the most ideal approach for determining the pharmaceutical quality of the finished dosage form. In the case of terminally sterilized parenteral products, the limitations of conventional batch testing have been successfully addressed with the application of parametric release (the release of a product based on control of process parameters instead of batch sterility testing at the end of the manufacturing process). Consequently, there has been an increasing interest in applying parametric release to other pharmaceutical dosage forms, beyond terminally sterilized parenteral products. For parametric release to be possible, manufacturers must be capable of designing quality into the product, monitoring the manufacturing processes, and controlling the quality of intermediates and finished products in real-time. Process analytical technology (PAT) has been thought to be capable of contributing to these prerequisites. It is believed that the appropriate use of PAT tools can eventually lead to the possibility of real-time release of other pharmaceutical dosage forms, by-passing the need for end-product batch testing. Hence, this literature review attempts to present the basic principles of PAT, introduce the various PAT tools that are currently available, present their recent applications to pharmaceutical processing, and explain the potential benefits that PAT can bring to conventional ways of processing and quality assurance of pharmaceutical products. Last but not least, current regulations governing the use of PAT and the manufacturing challenges associated with PAT implementation are also discussed. Pharmaceutical products are generally subjected to end-product batch testing as a means of quality control. Due to the inherent limitations of conventional batch testing, this is not the most

  19. Combining two open source tools for neural computation (BioPatRec and Netlab) improves movement classification for prosthetic control.

    Science.gov (United States)

    Prahm, Cosima; Eckstein, Korbinian; Ortiz-Catalan, Max; Dorffner, Georg; Kaniusas, Eugenijus; Aszmann, Oskar C

    2016-08-31

    Controlling a myoelectric prosthesis for upper limbs is increasingly challenging for the user as more electrodes and joints become available. Motion classification based on pattern recognition with a multi-electrode array allows multiple joints to be controlled simultaneously. Previous pattern recognition studies are difficult to compare, because individual research groups use their own data sets. To resolve this shortcoming and to facilitate comparisons, open access data sets were analysed using components of BioPatRec and Netlab pattern recognition models. Performances of the artificial neural networks, linear models, and training program components were compared. Evaluation took place within the BioPatRec environment, a Matlab-based open source platform that provides feature extraction, processing and motion classification algorithms for prosthetic control. The algorithms were applied to myoelectric signals for individual and simultaneous classification of movements, with the aim of finding the best performing algorithm and network model. Evaluation criteria included classification accuracy and training time. Results in both the linear and the artificial neural network models demonstrated that Netlab's implementation using scaled conjugate training algorithm reached significantly higher accuracies than BioPatRec. It is concluded that the best movement classification performance would be achieved through integrating Netlab training algorithms in the BioPatRec environment so that future prosthesis training can be shortened and control made more reliable. Netlab was therefore included into the newest release of BioPatRec (v4.0).

  20. Inline UV/Vis spectroscopy as PAT tool for hot-melt extrusion.

    Science.gov (United States)

    Wesholowski, Jens; Prill, Sebastian; Berghaus, Andreas; Thommes, Markus

    2018-01-11

    Hot-melt extrusion on co-rotating twin screw extruders is a focused technology for the production of pharmaceuticals in the context of Quality by Design. Since it is a continuous process, the potential for minimizing product quality fluctuation is enhanced. A typical application of hot-melt extrusion is the production of solid dispersions, where an active pharmaceutical ingredient (API) is distributed within a polymer matrix carrier. For this dosage form, the product quality is related amongst others to the drug content. This can be monitored on- or inline as critical quality attribute by a process analytical technology (PAT) in order to meet the specific requirements of Quality by Design. In this study, an inline UV/Vis spectrometer from ColVisTec was implemented in an early development twin screw extruder and the performance tested in accordance to the ICH Q2 guideline. Therefore, two API (carbamazepine and theophylline) and one polymer matrix (copovidone) were considered with the main focus on the quantification of the drug load. The obtained results revealed the suitability of the implemented PAT tool to quantify the drug load in a typical range for pharmaceutical applications. The effort for data evaluation was minimal due to univariate data analysis, and in combination with a measurement frequency of 1 Hz, the system is sufficient for real-time data acquisition.

  1. Development of Process Analytical Technology (PAT) methods for controlled release pellet coating.

    Science.gov (United States)

    Avalle, P; Pollitt, M J; Bradley, K; Cooper, B; Pearce, G; Djemai, A; Fitzpatrick, S

    2014-07-01

    This work focused on the control of the manufacturing process for a controlled release (CR) pellet product, within a Quality by Design (QbD) framework. The manufacturing process was Wurster coating: firstly layering active pharmaceutical ingredient (API) onto sugar pellet cores and secondly a controlled release (CR) coating. For each of these two steps, development of a Process Analytical Technology (PAT) method is discussed and also a novel application of automated microscopy as the reference method. Ultimately, PAT methods should link to product performance and the two key Critical Quality Attributes (CQAs) for this CR product are assay and release rate, linked to the API and CR coating steps respectively. In this work, the link between near infra-red (NIR) spectra and those attributes was explored by chemometrics over the course of the coating process in a pilot scale industrial environment. Correlations were built between the NIR spectra and coating weight (for API amount), CR coating thickness and dissolution performance. These correlations allow the coating process to be monitored at-line and so better control of the product performance in line with QbD requirements. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. JOHN DEWEY’S EDUCATIONAL THEORY AND EDUCATIONAL IMPLICATIONS OF HOWARD GARDNER’S MULTIPLE INTELLIGENCES THEORY

    Directory of Open Access Journals (Sweden)

    Elena Achkovska Leshkovska

    2016-12-01

    Full Text Available Since 1983, when Howard Gardner published his theory of multiple intelligences, educators have begun to incorporate this new model into school programs. However, the idea of multimodal teaching is hardly a new concept. Many pioneers of modern education, such as: J. J. Rousseau, J.H. Pestalozzi, M. Montessory, J. Dewey, suggested educational models that oppose uniformity and predominantly verbal teaching. The aim of the research presented in this paper is to identify and compare compatible elements of educational ideas of John Dewey and Howard Gardner. The research is based on historical-comparative method and content analysis technique and is focused on exploring three key elements of intersection: curriculum, methods of teaching and learning, and teachers’ role. Regarding the curriculum, both authors prefer integrated and thematic curriculum based on real-life context. They also agree on student-centred teaching where implementation of variety of active methods of learning will give opportunity to students to express their specific identity. Teacher’s role in both concepts is to link students’ personal experiences and characteristics to the material being studied and to the school life in general. The findings imply that educational implications of Gardner’s theory can be considered as a continuation of Dewey’s progressive vision of classroom teaching and school organization.

  3. Staphylococcus aureus, evolución de un viejo patógeno

    Directory of Open Access Journals (Sweden)

    Ileana Álvarez Lam

    2012-12-01

    Full Text Available El Staphylococcus aureus está considerado uno de los microorganismos más importantes en la práctica médica diaria. Es capaz de provocar una amplia gama de enfermedades, ya sea por acción directa o mediante la acción de sus toxinas. El tratamiento de estas infecciones se ha convertido en algo extraordinariamente complejo en la época actual como consecuencia de la aparición en la comunidad de cepas de S. aureus, resistentes a la meticillina, que provocan infecciones en pacientes sin factores de riesgo, fundamentalmente niños y adolescentes. En este artículo se hace una revisión, que va desde los cambios en la epidemiología de este patógeno, hasta las implicaciones que para el tratamiento médico presupone este fenómeno.

  4. Good Modeling Practice for PAT Applications: Propagation of Input Uncertainty and Sensitivity Analysis

    DEFF Research Database (Denmark)

    Sin, Gürkan; Gernaey, Krist; Eliasson Lantz, Anna

    2009-01-01

    The uncertainty and sensitivity analysis are evaluated for their usefulness as part of the model-building within Process Analytical Technology applications. A mechanistic model describing a batch cultivation of Streptomyces coelicolor for antibiotic production was used as case study. The input...... compared to the large uncertainty observed in the antibiotic and off-gas CO2 predictions. The output uncertainty was observed to be lower during the exponential growth phase, while higher in the stationary and death phases - meaning the model describes some periods better than others. To understand which...... promising for helping to build reliable mechanistic models and to interpret the model outputs properly. These tools make part of good modeling practice, which can contribute to successful PAT applications for increased process understanding, operation and control purposes. © 2009 American Institute...

  5. Test of a sample container for shipment of small size plutonium samples with PAT-2

    International Nuclear Information System (INIS)

    Kuhn, E.; Aigner, H.; Deron, S.

    1981-11-01

    A light-weight container for the air transport of plutonium, to be designated PAT-2, has been developed in the USA and is presently undergoing licensing. The very limited effective space for bearing plutonium required the design of small size sample canisters to meet the needs of international safeguards for the shipment of plutonium samples. The applicability of a small canister for the sampling of small size powder and solution samples has been tested in an intralaboratory experiment. The results of the experiment, based on the concept of pre-weighed samples, show that the tested canister can successfully be used for the sampling of small size PuO 2 -powder samples of homogeneous source material, as well as for dried aliquands of plutonium nitrate solutions. (author)

  6. PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI.

    Science.gov (United States)

    Zhou, Luwei; Xu, Manfei; Wu, Zhisheng; Shi, Xinyuan; Qiao, Yanjiang

    2016-01-01

    Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed. Copyright © 2015 John Wiley & Sons, Ltd.

  7. Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides

    DEFF Research Database (Denmark)

    Frølund, Sidsel; Langthaler, Louise; Kall, Morten A

    2012-01-01

    -Sar as substrates of the amino acid transporter PAT1. The aim of the present study is to investigate if other Gly-containing dipeptides interact with PAT1, and whether they can inhibit PAT1 mediated drug absorption, in vitro and in vivo. The in vitro methods included two-electrode voltage clamp measurements on h...... of different dipeptides. The in vivo part consisted of a pharmacokinetic study in rats following oral administration of gaboxadol and preadministration of 200 mg/kg dipeptide. The results showed that in hPAT1 expressing oocytes Gly-Tyr, Gly-Pro, and Gly-Phe inhibited currents induced by drug substances......, the present study identifies selected dipeptides as inhibitors of PAT1 mediated drug absorption in various in vitro models....

  8. Evaluación de patógenos en clones de lulo (Solanum quitoense Lam.

    Directory of Open Access Journals (Sweden)

    Consuelo Montes Rojas

    2010-04-01

    Full Text Available En el noroccidente de Popayán, Colombia, se evaluó la presencia de plagas causadas por patógenos en 42 clones de lulo (Solanum quitoense Lam.. Los clones fueron plantados en bolsas plásticas, donde se desarrollaron por 3 semanas antes de ser trasplantados al campo. Se utilizó un diseño de bloques completos al azar con cuatro repeticiones, la parcela útil estuvo conformada por 6 plantas, las cuales se sembraron a ‘tresbolillo’ a 2.5 m entre surcos y 2 m entre plantas. Para determinar el efecto de las plagas en el cultivo, se calculó el porcentaje de incidencia y severidad del ataque. La incidencia se evaluó como porcentaje de plantas afectadas, y la severidad como porcentaje de tejido afectado por el patógeno. Las enfermedades más limitantes para los 42 clones fueron: gota (Phytophthora infestans que provocó una mortalidad de plantas superior a 40%; fusarium (Fusarium oxysporum que se presentó en 12 de los clones evaluados; antracnosis (Colletotrichum sp. que afectó 21 clones, los cuales se clasificaron entre tolerantes y medianamente tolerantes; y mancha clorótica (Cladosporium sp. que afectó 21 clones, clasificados como susceptibles. Los clones PL19, PL24, PL11, PL35 fueron medianamente tolerantes. Se seleccionaron por supervivencia los clones: JY E1 (52.2%, PH E 1 (45.8%, VM E2 (45.8%; por supervivencia y por tolerancia a Fusarium oxysporum los clones PL35, PL11, PL24, PL8, PL19, 120052, 120043, ORE1, AGE1. Los clones SER 7, SER 15, SER 9, SEC 31, SEC 27 presentaron alta mortalidad pero se seleccionaron por ser medianamente tolerantes a gota, tolerantes a antracnosis y medianamente resistentes a nematodos, con buen vigor y producción.

  9. Introducing uncertainty analysis of nucleation and crystal growth models in Process Analytical Technology (PAT) system design of crystallization processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan; Gernaey, Krist

    2013-01-01

    This paper presents the application of uncertainty and sensitivity analysis as part of a systematic modelbased process monitoring and control (PAT) system design framework for crystallization processes. For the uncertainty analysis, the Monte Carlo procedure is used to propagate input uncertainty...

  10. At-line process analytical technology (PAT) for more efficient scale up of biopharmaceutical microfiltration unit operations.

    Science.gov (United States)

    Watson, Douglas S; Kerchner, Kristi R; Gant, Sean S; Pedersen, Joseph W; Hamburger, James B; Ortigosa, Allison D; Potgieter, Thomas I

    2016-01-01

    Tangential flow microfiltration (MF) is a cost-effective and robust bioprocess separation technique, but successful full scale implementation is hindered by the empirical, trial-and-error nature of scale-up. We present an integrated approach leveraging at-line process analytical technology (PAT) and mass balance based modeling to de-risk MF scale-up. Chromatography-based PAT was employed to improve the consistency of an MF step that had been a bottleneck in the process used to manufacture a therapeutic protein. A 10-min reverse phase ultra high performance liquid chromatography (RP-UPLC) assay was developed to provide at-line monitoring of protein concentration. The method was successfully validated and method performance was comparable to previously validated methods. The PAT tool revealed areas of divergence from a mass balance-based model, highlighting specific opportunities for process improvement. Adjustment of appropriate process controls led to improved operability and significantly increased yield, providing a successful example of PAT deployment in the downstream purification of a therapeutic protein. The general approach presented here should be broadly applicable to reduce risk during scale-up of filtration processes and should be suitable for feed-forward and feed-back process control. © 2015 American Institute of Chemical Engineers.

  11. CFD Modelling of a Pump as Turbine (PAT with Rounded Leading Edge Impellers for Micro Hydro Systems

    Directory of Open Access Journals (Sweden)

    Ismail Mohd Azlan

    2017-01-01

    Full Text Available A Pump as Turbine (PAT is one of micro hydro system components that is used to substitute a commercially available turbine due to its wide availability and low acquisition cost. However, PAT have high hydraulic losses due to differences in pump-turbine operation and hydraulic design. The fluid flowing inside the PAT is subjected to hydraulic losses due to the longer flow passage and unmatched fluid flow within the wall boundaries. This paper presents the effect of rounding the impeller leading edges of the pump on turbine performance. A CFD model of a PAT was designed to simulate virtual performance for the analysis. The aim of this study is to observe the internal hydraulic performance resulting from the changes in the performance characteristics. Highest efficiency was recorded at 17.0 l/s, an increase of 0.18%. The simulation results reveal that there is an improvement in hydraulic performance at overflow operation. The velocity vector visualization shows that there is a reduction in wake and consequently less flow separation along impeller flow passages. However, adjusting the sensitive impeller inlet geometry will also alter the velocity inlet vector and consequently change the velocity triangles for the turbo machinery system.

  12. Walter Max Dale (formerly Deutsch) (1894-1969): pioneer and eminent radiobiochemist at the Christie Hospital and Holt Radium Institute, Manchester.

    Science.gov (United States)

    Shreeve, David R

    2010-05-01

    The political upheaval in Germany in 1933 and subsequent movement of medical scholars with the support of the Rockefeller Foundation allowed Manchester to benefit from the arrival of Dr Walter Deutsch, later known as Dr Walter Dale. His research background enabled him to develop a radiobiochemistry laboratory at the Christie Hospital and Holt Radium Institute where he became a world authority on the effects of X-rays on enzymes and also the protective effect of additional solutes. In 1959 he initiated and then edited the International Journal of Radiation Biology. By the time of his retirement in 1962 the strength of his research resulted in his laboratory being recognized by the Medical Research Council.

  13. Comparative sound velocity measurements between porous rock and fully-dense material under crustal condition: The cases of Darley Dale sandstone and copper block

    Science.gov (United States)

    Kung, J.; Chien, Y. V.; Wu, W.; Dong, J.; Chang, Y.; Tsai, C.; Yang, M.; Wang, K.

    2012-12-01

    Previous studies showed that the voids and their geometry in the sedimentary rocks have great influence on the compressibility of rock, which reflects on its elastic velocities. Some models were developed to discuss the relations among velocity, porosity and void geometry. Therefore, the information of porosity, and void geometry and its distribution in rock is essential for understanding how the elastic properties of porous rocks affected by their poregeometry. In this study, we revisited a well-studied porous rock, Darley Dale sandstone, which has been studied by different groups with different purposes. Most of them are the deformation experiments. Different from previous studies, we measured the sound velocity of Darley dale sandstone under hydrostatic conditions. Also, we employed different techniques to investigate the pore geometry and porosity of Darley Dale sandstone to gain the insight of velocity changing behavior under the crustal conditions. Here, we measured a fully-dense copper block for a comparison. We performed X-ray CT scanning (XCT) to image the pore space of sandstone to construct the 3-D image of pore geometry, distribution and the pore size. The CT image data are allowed us to estimate the porosity of sandstone, too. One the other hand, the porosity of sample was measured using imbibitions method at ambient conditions and helium porosimeter at high pressure (up to 150 MPa). A set of specimens were cored from Darley Dale sandstone block. P and S wave velocities of specimens were measured at ambient conditions. We also performed high pressure velocity measurements on a selected rock specimen and a copper block up to 150 MPa under dry condition. Porosity of a set of rock specimens measured by imbibitions method was spanned from 6% to 15%, largely distributed within a range of 8%-11%. Compared the porosity obtained from three different techniques, imbibitions method, helium porosimeter and XCT, values from those measurements are in good agreement

  14. Howard S. Becker, La Bonne focale. De l’utilité des cas particuliers en sciences sociales

    OpenAIRE

    Feryn, Mathieu

    2017-01-01

    Comment peut-on comprendre de longs processus que nous observons sur le terrain dans le cadre des enquêtes menées en sciences humaines et sociales ? Rédigé par Howard S. Becker, l’ouvrage La Bonne focale. De l’utilité des cas particuliers en sciences sociales illustre la manière dont le sociologue de terrain investit sa recherche en étudiant des cas particuliers. Faisant le point sur sa méthodologie et son évolution depuis les trente dernières années ; d’une part, l’auteur met en relation ses...

  15. Howard Atwood Kelly (1858-1943): founding Professor of Gynecology at Johns Hopkins Hospital and pioneer American radium therapist

    International Nuclear Information System (INIS)

    Robison, R. F.

    2010-01-01

    To date no objective scientific medical biography has been published on Howard Atwood Kelly, one of America's foremost radium pioneers. He had become internationally known since 1889 as the founding Chief of the Gynecology Service at Johns Hopkins, well before the discovery of radium. He was also later to maintain his own hospital in Baltimore. He was a multifaceted man and his biography provides some fascinating reading about the treatment of gynaecological cancer in the USA at the end of the 19 th century and well into the 20 th century. An Appendix is included which contains extracts from Curtis Bumam's 1936 Janeway Memorial Lecture on 'Early Experiences with Radium' which was published (without quoting any references) in the American Journal of Roentgenology (AJR). Bumam was probably the most important of Kelly's collaborators and he provides unique personal and scientific insights on Kelly and the trials (and) tribulations of obtaining and using radium in 1911. (author)

  16. Early Opportunities Research Partnership Between Howard University, University of Maryland Baltimore County and NASA Goddard for Engaging Underrepresented STEM Students in Earth and Space Sciences

    Science.gov (United States)

    Misra, P.; Venable, D. D.; Hoban, S.; Demoz, B.; Bleacher, L.; Meeson, B. W.; Farrell, W. M.

    2017-12-01

    Howard University, University of Maryland Baltimore County and NASA Goddard Space Flight Center (GSFC) are collaborating to engage underrepresented STEM students and expose them to an early career pathway in NASA-related Earth & Space Science research. The major goal is to instill interest in Earth and Space Science to STEM majors early in their academic careers, so that they become engaged in ongoing NASA-related research, motivated to pursue STEM careers, and perhaps become part of the future NASA workforce. The collaboration builds on a program established by NASA's Dynamic Response of the Environments of Asteroids, the Moon and the moons of Mars (DREAM2) team to engage underrepresented students from Howard in summer internships. Howard leveraged this program to expand via NASA's Minority University Research and Education Project (MUREP) funding. The project pairs Howard students with GSFC mentors and engages them in cutting-edge Earth and Space Science research throughout their undergraduate tenure. The project takes a multi-faceted approach, with each year of the program specifically tailored to each student's strengths and addressing their weaknesses, so that they experience a wide array of enriching research and professional development activities that help them grow both academically and professionally. During the academic year, the students are at Howard taking a full load of courses towards satisfying their degree requirements and engaging in research with their GSFC mentors via regular telecons, e-mail exchanges, video chats & on an average one visit per semester to GSFC for an in-person meeting with their research mentor. The students extend their research with full-time summer internships at GSFC, culminating in a Capstone Project and Senior Thesis. As a result, these Early Opportunities Program students, who have undergone rigorous training in the Earth and Space Sciences, are expected to be well-prepared for graduate school and the NASA workforce.

  17. Evaluación de patógenos en clones de lulo (Solanum quitoense Lam.

    Directory of Open Access Journals (Sweden)

    Montes Rojas Consuelo

    2010-06-01

    Full Text Available

    En el noroccidente de Popayán, Colombia, se evaluó la presencia de plagas causadas por patógenos en 42 clones de lulo (Solanum quitoense Lam.. Los clones fueron plantados en bolsas plásticas, donde se desarrollaron por 3 semanas antes de ser trasplantados al campo. Se utilizó un diseño de bloques completos al azar con cuatro repeticiones, la parcela útil estuvo conformada por 6 plantas, las cuales se sembraron a 'tresbolillo' a 2.5 m entre surcos y 2 m entre plantas. Para determinar el efecto de las plagas en el cultivo, se calculó el porcentaje de incidencia y severidad del ataque. La incidencia se evaluó como porcentaje de plantas afectadas, y la severidad como porcentaje de tejido afectado por el patógeno. Las enfermedades más limitantes para los 42 clones fueron: gota (Phytophthora infestans que provocó una mortalidad de plantas superior a 40%; fusarium (Fusarium oxysporum que se presentó en 12 de los clones evaluados; antracnosis (Colletotrichum sp. que afectó 21 clones, los cuales se clasificaron entre tolerantes y medianamente tolerantes; y mancha clorótica (Cladosporium sp. que afectó 21 clones, clasificados como susceptibles. Los clones PL19, PL24, PL11, PL35 fueron medianamente tolerantes. Se seleccionaron por supervivencia los clones: JY E1 (52.2%, PH E 1 (45.8%, VM E2 (45.8%; por supervivencia y por tolerancia a Fusarium oxysporum los clones PL35, PL11, PL24, PL8, PL19, 120052, 120043, ORE1, AGE1. Los clones SER 7, SER 15, SER 9, SEC 31, SEC 27 presentaron alta mortalidad pero se seleccionaron por ser medianamente tolerantes a gota, tolerantes a antracnosis y medianamente resistentes a nematodos, con buen vigor y producción.

  18. Photon activated therapy (PAT) using monochromatic synchrotron X-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy.

    Science.gov (United States)

    Choi, Gi-Hwan; Seo, Seung-Jun; Kim, Ki-Hong; Kim, Hong-Tae; Park, Sung-Hwan; Lim, Jae-Hong; Kim, Jong-Ki

    2012-10-31

    X-rays are known to interact with metallic nanoparticles, producing photoelectric species as radiosensitizing effects, and have been exploited in vivo mainly with gold nanoparticles. The purpose of this study was to investigate the potential of sensitizing effect of iron oxide nanoparticles for photon activated therapy. X-rays photon activated therapy (PAT) was studied by treating CT26 tumor cells and CT26 tumor-bearing mice loaded with 13-nm diameter FeO NP, and irradiating them at 7.1 keV near the Fe K-edge using synchrotron x-rays radiation. Survival of cells was determined by MTT assay, and tumor regression assay was performed for in vivo model experiment. The results of PAT treated groups were compared with x-rays alone control groups. A more significant reduction in viability and damage was observed in the FeO NP-treated irradiated cells, compared to the radiation alone group (p X-rays. Since 7.1 keV X-rays is attenuated very sharply in the tissue, FeO NP-PAT may have promise as a potent treatment option for superficial malignancies in the skin, like chest wall recurrence of breast cancer.

  19. Inline monitoring and a PAT strategy for pharmaceutical hot melt extrusion.

    Science.gov (United States)

    Wahl, Patrick R; Treffer, Daniel; Mohr, Stefan; Roblegg, Eva; Koscher, Gerold; Khinast, Johannes G

    2013-10-15

    Implementation of continuous manufacturing in the pharmaceutical industry requires tight process control. This study focuses on a PAT strategy for hot melt extrusion of vegetable calcium stearate (CaSt) as matrix carrier and paracetamol as active pharmaceutical ingredient (API). The extrusion was monitored using in-line near-infrared (NIR) spectroscopy. A NIR probe was located in the section between the extrusion screws and the die, using a novel design of the die channel. A chemometric model was developed based on premixes at defined concentrations and was implemented in SIPAT for real time API concentration monitoring. Subsequently, step experiments were performed for different API concentrations, screw speeds and screw designs. The predicted API concentration was in good agreement with the pre-set concentrations. The transition from one API plateau to another was a smooth curve due to the mixing behaviour of the extruder. The accuracy of the model was confirmed via offline HPLC analysis. The screw design was determined as the main influential factor on content uniformity (CU). Additionally the influence of multiple feeders had a significant impact on CU. The results demonstrate that in-line NIR measurements is a powerful tool for process development (e.g., mixing characterization), monitoring and further control strategies. Copyright © 2013. Published by Elsevier B.V.

  20. PAT Design Strategy for Energy Recovery in Water Distribution Networks by Electrical Regulation

    Directory of Open Access Journals (Sweden)

    Helena M. Ramos

    2013-01-01

    Full Text Available In the management of water distribution networks, large energy savings can be yielded by exploiting the head drop due to the network pressure control strategy, i.e., for leak reductions. Hydropower in small streams is already exploited, but technical solutions combining efficiency and economic convenience are still required. In water distribution networks, an additional design problem comes out from the necessity of ensuring a required head drop under variable operating conditions, i.e., head and discharge variations. Both a hydraulic regulation (HR—via a series-parallel hydraulic circuit- and an electrical regulation (ER—via inverter- are feasible solutions. A design procedure for the selection of a production device in a series-parallel hydraulic circuit has been recently proposed. The procedure, named VOS (Variable Operating Strategy, is based on the overall plant efficiency criteria and is applied to a water distribution network where a PAT (pump as a turbine is used in order to produce energy. In the present paper the VOS design procedure has been extended to the electrical regulation and a comparison between HR and ER efficiency and flexibility within a water distribution network is shown: HR was found more flexible than ER and more efficient. Finally a preliminary economic study has been carried out in order to show the viability of both systems, and a shorter payback period of the electromechanical equipment was found for HR mode.

  1. Investigating Trauma in Narrating World War I: A Psychoanalytical Reading of Pat Barker’s Regeneration

    Directory of Open Access Journals (Sweden)

    Bakhtiar Sadjadi

    2016-12-01

    Full Text Available The present paper seeks to critically read Pat Barker’s Regeneration in terms of Cathy Caruth’s psychoanalytic study of trauma. This analysis attempts to trace the concepts of latency, post-traumatic stress disorders, traumatic memory, and trauma in Barker’s novel in order to explore how trauma and history are interrelated in the narrative of past history and, particularly, in the history of World War I. The present paper also demonstrates how Barker’s novel Regeneration acts as the narrative of trauma that vocalizes the silenced history of shell-shocked soldiers of World War I to represent British society, the history that has been concealed due to social and individual factors. The study thus investigates the dissociative disorders which are experienced by traumatized survivors of World War I as the aftermath of traumatic experiences of wartime. In addition, it argues how time moves for the traumatized victim and how the notion of latency in terms of Caruth’s theory is traceable in Barker’s novel. In Regeneration, the traumatized survivors are haunted with traumatic memory of past history; furthermore, past history constantly disrupts their present and the victims are in continuous shift from present time to past time. Time thus loses its linearity in the narrative of traumatized survivors. Keywords: Latency, post-traumatic stress disorders, traumatic memory, trauma

  2. Network and user interface for PAT DOME virtual motion environment system

    Science.gov (United States)

    Worthington, J. W.; Duncan, K. M.; Crosier, W. G.

    1993-01-01

    The Device for Orientation and Motion Environments Preflight Adaptation Trainer (DOME PAT) provides astronauts a virtual microgravity sensory environment designed to help alleviate tye symptoms of space motion sickness (SMS). The system consists of four microcomputers networked to provide real time control, and an image generator (IG) driving a wide angle video display inside a dome structure. The spherical display demands distortion correction. The system is currently being modified with a new graphical user interface (GUI) and a new Silicon Graphics IG. This paper will concentrate on the new GUI and the networking scheme. The new GUI eliminates proprietary graphics hardware and software, and instead makes use of standard and low cost PC video (CGA) and off the shelf software (Microsoft's Quick C). Mouse selection for user input is supported. The new Silicon Graphics IG requires an Ethernet interface. The microcomputer known as the Real Time Controller (RTC), which has overall control of the system and is written in Ada, was modified to use the free public domain NCSA Telnet software for Ethernet communications with the Silicon Graphics IG. The RTC also maintains the original ARCNET communications through Novell Netware IPX with the rest of the system. The Telnet TCP/IP protocol was first used for real-time communication, but because of buffering problems the Telnet datagram (UDP) protocol needed to be implemented. Since the Telnet modules are written in C, the Adap pragma 'Interface' was used to interface with the network calls.

  3. Extratos vegetais no controle de patógenos em sementes de Pterogyne nitens Tul

    Directory of Open Access Journals (Sweden)

    José George Ferreira Medeiros

    Full Text Available A demanda por sementes florestais para reflorestamento e outras finalidades poderá se constituir em um meio de disseminação de patógenos, que podem comprometer a qualidade fisiológica das sementes. Assim, objetivou-se avaliar o efeito de extratos naturais de melão-de-são-caetano (Momordica charantia e alamanda (Allamanda blanchetti sobre a micoflora e a fisiologia de sementes de Pterogyne nitens. Os seguintes tratamentos fitossanitários foram avaliados: testemunha (sementes não tratadas; fungicida Captan® (240 g/100 kg, e extratos de melão-de-são-caetano e alamanda nas concentrações de 10, 100, 500 e 1000 ppm. No teste de germinação, avaliaram-se a porcentagem de germinação, a primeira contagem e o índice de velocidade de germinação (IVG. Os extratos vegetais de melão-de-são-caetano e alamanda reduziram a incidência de fungos e aumentaram o percentual de germinação das sementes de P. nitens.

  4. Process Analytical Technology (PAT): batch-to-batch reproducibility of fermentation processes by robust process operational design and control.

    Science.gov (United States)

    Gnoth, S; Jenzsch, M; Simutis, R; Lübbert, A

    2007-10-31

    The Process Analytical Technology (PAT) initiative of the FDA is a reaction on the increasing discrepancy between current possibilities in process supervision and control of pharmaceutical production processes and its current application in industrial manufacturing processes. With rigid approval practices based on standard operational procedures, adaptations of production reactors towards the state of the art were more or less inhibited for long years. Now PAT paves the way for continuous process and product improvements through improved process supervision based on knowledge-based data analysis, "Quality-by-Design"-concepts, and, finally, through feedback control. Examples of up-to-date implementations of this concept are presented. They are taken from one key group of processes in recombinant pharmaceutical protein manufacturing, the cultivations of genetically modified Escherichia coli bacteria.

  5. Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)

    DEFF Research Database (Denmark)

    Aksu, Buket; De Beer, Thomas; Folestad, Staffan

    2012-01-01

    however have the potential to provide considerable challenges to the establishment of cost effective and robust supply chains. To guarantee product quality and surety of supply for essential medicines it is necessary that manufacturing science keeps pace with advances in pharmaceutical R......Substantial changes in Pharmaceutical R&D strategy are required to address existing issues of low productivity, imminent patent expirations and pressures on pricing. Moves towards personalized healthcare and increasing diversity in the nature of portfolios including the rise of biopharmaceuticals......&D. In this position paper, the EUFEPS QbD and PAT Sciences network make recommendations that European industry, academia and health agencies focus attention on delivering step changes in science and technology in a number of key themes. These subject areas, all underpinned by the sciences allied to QbD and PAT...

  6. Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1

    DEFF Research Database (Denmark)

    Larsen, Mie; Larsen, Birger Brodin; Frølund, Bente

    2008-01-01

    The objective of this study was to investigate transepithelial amino acid transport as a function of Caco-2 cell culture time. Furthermore, the objective was to investigate apical uptake characteristics of hPAT1-mediated transport under various experimental conditions. Apical amino acid uptake......, which has been shown to function as a carboxylic acid bioisostere for substrates of the GABA receptor and transport systems....

  7. Eliminación de patógenos en biosólidos por estabilización alcalina

    Directory of Open Access Journals (Sweden)

    Silva Leal Jorge Antonio

    2009-09-01

    Full Text Available La Planta de Tratamiento de Aguas Residuales de Cañaveralejo –PTAR-C de Cali– Colombia, produce alrededor de 100 t/día de biosólidos que, aunque no tienen restricción por metales pesados, son clase B por el nivel de microorganismos patógenos y parásitos. En un diseño completamente al azar, conformado por seis tratamientos con su respectivo duplicado, se evaluó la estabilización alcalina con dosis del 9% peso a peso de cal viva e hidratada, aplicada a pilas de 0.5 t de biosólidos húmedos (66.5% y secos a temperatura ambiente (25 - 31°C durante 72 h (humedad 50.1%. Con la estabilización alcalina el pH aumentó a valores superiores a 12 unidades durante el tiempo suficiente para garantizar la reducción de patógenos y parásitos, alcanzando un material clase A; sin embargo, el biosólido seco facilitó la formación de grumos que dificultaron las labores de homogenización del sustrato con los alcalinizantes, factor indeseable para la eficiente reducción de patógenos.

  8. Overview of PAT process analysers applicable in monitoring of film coating unit operations for manufacturing of solid oral dosage forms.

    Science.gov (United States)

    Korasa, Klemen; Vrečer, Franc

    2018-01-01

    Over the last two decades, regulatory agencies have demanded better understanding of pharmaceutical products and processes by implementing new technological approaches, such as process analytical technology (PAT). Process analysers present a key PAT tool, which enables effective process monitoring, and thus improved process control of medicinal product manufacturing. Process analysers applicable in pharmaceutical coating unit operations are comprehensibly described in the present article. The review is focused on monitoring of solid oral dosage forms during film coating in two most commonly used coating systems, i.e. pan and fluid bed coaters. Brief theoretical background and critical overview of process analysers used for real-time or near real-time (in-, on-, at- line) monitoring of critical quality attributes of film coated dosage forms are presented. Besides well recognized spectroscopic methods (NIR and Raman spectroscopy), other techniques, which have made a significant breakthrough in recent years, are discussed (terahertz pulsed imaging (TPI), chord length distribution (CLD) analysis, and image analysis). Last part of the review is dedicated to novel techniques with high potential to become valuable PAT tools in the future (optical coherence tomography (OCT), acoustic emission (AE), microwave resonance (MR), and laser induced breakdown spectroscopy (LIBS)). Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Mr. Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, United Kingdom

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photos 01,02: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (third from left, front) in front of the ATLAS End-Cap Toroid vacuum vessel in the ATLAS assembly hall with, from left to right, Fred Wickens, Chris Jones, Peter Fletcher, Ray Browne, Neil Geddes, Jim Fleming, Anne Trefethen, Jim Wilson, Edwin Towndrow, Sharon Bonfield, Guy Rickett, Ken Smith, Peter Jenni. Photo 03: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (fifth from left) visiting ATLAS assembly hall with, from left to right, Jim Wilson, Peter Jenni, Ken Smith, Edwin Towndrow, Ray Brown, Chris Jones, Neil Geddes, Sharon Bonfield, Anne Trefethen, Jim Fleming, Fred Wickens. Photo 04: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (fourth from right) in front of the ATLAS Barrel Toroid coil casing in the ATLAS assembly hall with, from left to right, Peter Jenni, Jim Wilson, Guy Rickett, Anne Trefethen, ...

  10. Eliminación de patógenos en biosólidos por estabilización alcalina

    Directory of Open Access Journals (Sweden)

    Patricia Torres Lozada

    2009-07-01

    Full Text Available La Planta de Tratamiento de Aguas Residuales de Cañaveralejo -PTAR-C de Cali- Colombia, produce alrededor de 100 t/día de biosólidos que, aunque no tienen restricción por metales pesados, son clase B por el nivel de microorganismos patógenos y parásitos. En un diseño completamente al azar, conformado por seis tratamientos con su respectivo duplicado, se evaluó la estabilización alcalina con dosis del 9% peso a peso de cal viva e hidratada, aplicada a pilas de 0.5 t de biosólidos húmedos (66.5% y secos a temperatura ambiente (25 - 31°C durante 72 h (humedad 50.1%. Con la estabilización alcalina el pH aumentó a valores superiores a 12 unidades durante el tiempo suficiente para garantizar la reducción de patógenos y parásitos, alcanzando un material clase A; sin embargo, el biosólido seco facilitó la formación de grumos que dificultaron las labores de homogenización del sustrato con los alcalinizantes, factor indeseable para la eficiente reducción de patógenos.

  11. Introducing uncertainty analysis of nucleation and crystal growth models in Process Analytical Technology (PAT) system design of crystallization processes.

    Science.gov (United States)

    Samad, Noor Asma Fazli Abdul; Sin, Gürkan; Gernaey, Krist V; Gani, Rafiqul

    2013-11-01

    This paper presents the application of uncertainty and sensitivity analysis as part of a systematic model-based process monitoring and control (PAT) system design framework for crystallization processes. For the uncertainty analysis, the Monte Carlo procedure is used to propagate input uncertainty, while for sensitivity analysis, global methods including the standardized regression coefficients (SRC) and Morris screening are used to identify the most significant parameters. The potassium dihydrogen phosphate (KDP) crystallization process is used as a case study, both in open-loop and closed-loop operation. In the uncertainty analysis, the impact on the predicted output of uncertain parameters related to the nucleation and the crystal growth model has been investigated for both a one- and two-dimensional crystal size distribution (CSD). The open-loop results show that the input uncertainties lead to significant uncertainties on the CSD, with appearance of a secondary peak due to secondary nucleation for both cases. The sensitivity analysis indicated that the most important parameters affecting the CSDs are nucleation order and growth order constants. In the proposed PAT system design (closed-loop), the target CSD variability was successfully reduced compared to the open-loop case, also when considering uncertainty in nucleation and crystal growth model parameters. The latter forms a strong indication of the robustness of the proposed PAT system design in achieving the target CSD and encourages its transfer to full-scale implementation. Copyright © 2013 Elsevier B.V. All rights reserved.

  12. Petroleum and Oil Fuel Lines (Apra Harbor through Antonio B. Won Pat Intl Airport to Tanguisson Power Plant), Guam, 2016, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is a line feature dataset showing the track of petroleum and oil fuel lines that transport hazardous fluids from Apra Harbor through the Antonio B. Won Pat...

  13. Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).

    Science.gov (United States)

    Edwards, Noel; Anderson, Catriona M H; Gatfield, Kelly M; Jevons, Mark P; Ganapathy, Vadivel; Thwaites, David T

    2011-01-01

    The H(+)-coupled amino acid transporter PAT2 (SLC36A2) transports the amino acids proline, glycine, alanine and hydroxyproline. A physiological role played by PAT2 in amino acid reabsorption in the renal proximal tubule is demonstrated by mutations in SLC36A2 that lead to an iminoglycinuric phenotype (imino acid and glycine uria) in humans. A number of proline, GABA and tryptophan derivatives were examined to determine if they function either as transported substrates or non-transported inhibitors of PAT2. The compounds were investigated following heterologous expression of rat PAT2 in Xenopus laevis oocytes. PAT2 function was characterised by: radiotracer uptake and competition (cis-inhibition) studies; radiotracer efflux and trans-stimulation; and measurement of substrate-induced positive inward current by two-electrode voltage-clamp. In general, the proline derivatives appeared to be transported substrates and the relative ability to induce current flow was closely related to the inhibitory effects on PAT2-mediated l-[(3)H]proline uptake. In contrast, certain heterocyclic GABA derivatives (e.g. l-pipecolic acid) were translocated only slowly. Finally, the tryptophan derivatives inhibited PAT2 function but did not undergo transport. l-Proline uptake was inhibited by 5-hydroxy-l-tryptophan (IC(50) 1.6±0.4mM), α-methyl-d,l-tryptophan (3.5±1.5mM), l-tryptophan, 1-methyl-l-tryptophan and indole-3-propionic acid. Although neither 5-hydroxy-l-tryptophan nor α-methyl-d,l-tryptophan were able to elicit inward current in PAT2-expressing oocytes both reduced the current evoked by l-proline. 5-Hydroxy-l-tryptophan and α-methyl-d,l-tryptophan were unable to trans-stimulate l-proline efflux from PAT2-expressing oocytes, confirming that the two compounds act as non-transported blockers of PAT2. These two tryptophan derivatives should prove valuable experimental tools in future investigations of the physiological roles of PAT2. Copyright © 2010 Elsevier B.V. All rights

  14. Alpha synchronization as a brain model for unconscious defense: An overview of the work of Howard Shevrin and his team.

    Science.gov (United States)

    Bazan, Ariane

    2017-10-01

    Howard Shevrin and his team have developed a stringent subliminal priming methodology, which experimentally approximates a situation of an internal, mental triggering of unconscious defense. Through a series of four studies they thus are able to bring evidence for this type of unconscious defense. With event-related potentials, three clinical studies show how synchronization of a specific brain wave, the alpha wave, known for its inhibitory function, is also induced by subliminally presented conflictual subject-specific stimuli. Therefore, alpha synchronization could serve as the brain mechanism of unconscious defense. The results only make sense if we suppose the existence of a dynamic unconscious, which has inherited childhood conflicts, and with privileged connections to neurotic symptom characteristics. Moreover, by showing that the unconscious conflict phrases, inferred by clinicians from clinical interviews, have a similar brain behavior, Shevrin and his team provide evidence that these inferences are not simply clinician-dependent subjective interpretations but also imply some form of independent mental reality. Finally, interpretation of the results has led us to propose two distinct physiological mechanisms for defense: one, unconscious defense, by alpha synchronization in connection with the drive derivatives, and another, repression, based on the indications of reality in connection with the ego. Copyright © 2017 Institute of Psychoanalysis.

  15. Simulations on the role of the egg parasite, Ooencyrtus kuvanae (Howard), in the population dynamics of the gypsy moth

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.W.; Williams, F.M.; Cameron, E.A.

    1983-04-01

    Computer simulations were run to examine the effects of Ooencyrtus kuvanae (Howard) parasitism on gypsy moth populations. Two difference equation models were used, one, a simple theoretical model containing only a few important components, the other, a more comprehensive model with component functions based on field data. The simulations of the first model showed that O. kuvanae cannot control gypsy moth populations by itself. Egg parasitism was most important during the outbreak and collapse phase of the gypsy moth population cycle, and was of little importance in the endemic phase. The endemic phase was, however, lower and lasted longer with O. kuvanae parasitism than without. Simulations with the second model generally supported these conclusions. The second set of simulations also demonstrated that due to the non-linearity of the density dependence of O. kuvanae parasitism, the gypsy moth population could be forced into a chaotic regime (unstable, aperiodic population behavior). The variation in parasitism rate from the simulations was compared with that of field populations and found to be essentially the same, indicating that the simulation models are realistic.

  16. Effects of temperature and packaging types on ergosterol and Howard mold count values of tomato paste during storage.

    Science.gov (United States)

    Ekinci, Raci; Kadakal, Çetin; Otağ, Mustafa

    2014-03-01

    The objective of the present study was to investigate the effects of temperature and packaging on ergosterol and Howard mold count (HMC) changes of tomato paste during storage. The other purpose of this study was to determine whether the measurement of ergosterol stability in tomato paste can be useful for the assessment of microbiological quality of tomato paste as related to the storage temperature (4, 20, 28, or 37°C) and time. Ergosterol analysis was done by using high-performance liquid chromatography. Tomato paste samples were packaged in either aseptic bags or tin boxes and stored at 4, 20, 28, or 37°C for a period of 10 months. The detection limit of ergosterol was 0.1 mg/kg. Measurements showed that packaging and storage temperatures of 28 and 37°C have a considerable influence on ergosterol and HMC changes in the product. The poor precision of the "percentage of discarded fruits" and HMC methods has increased the importance of ergosterol for the microbiological quality evaluation of tomato and tomato products. This article reports the data from what we believe to be the first survey for the influence of storage temperature and packaging material on ergosterol and HMC changes of tomato paste during storage.

  17. The utility of Pinus sylvestris L. in dendrochemical investigations: Pollution impact of lead mining and smelting in Darley Dale, Derbyshire, UK

    International Nuclear Information System (INIS)

    Lageard, J.G.A.; Howell, J.A.; Rothwell, J.J.; Drew, I.B.

    2008-01-01

    This research investigates atmospheric pollution from an isolated and increasingly productive lead-smelting site by examining the dendrochemistry of Pinus sylvestris growing in the local environment and at control sites. Tree increment cores and soil in the rooting environment were analysed for lead content. Inter-site comparisons of lead-in-soil suggest that contamination of the soil may be a less important pathway for lead inclusion within wood than pathways via bark or needles. Levels of lead-in-wood (up to 38 mg kg -1 ) are at the upper end of those previously reported. There is evidence of radial translocation of lead towards the heartwood and variability in intra-site dendrochemical records. Mean site lead-in-wood records can however be related to a well-documented pollution chronology and also suggest the importance of local topography in the dispersal and deposition of particulate lead. This study demonstrates that P. sylvestris can be used to estimate the scale and timing of past pollution episodes in similar environmental contexts to those investigated at Darley Dale, where precisely dated pollution chronologies are lacking. - Mean site dendrochemical records for Pinus sylvestris can be used to estimate the general scale and timing of atmospheric pollution episodes

  18. The utility of Pinus sylvestris L. in dendrochemical investigations: pollution impact of lead mining and smelting in Darley Dale, Derbyshire, UK.

    Science.gov (United States)

    Lageard, J G A; Howell, J A; Rothwell, J J; Drew, I B

    2008-05-01

    This research investigates atmospheric pollution from an isolated and increasingly productive lead-smelting site by examining the dendrochemistry of Pinus sylvestris growing in the local environment and at control sites. Tree increment cores and soil in the rooting environment were analysed for lead content. Inter-site comparisons of lead-in-soil suggest that contamination of the soil may be a less important pathway for lead inclusion within wood than pathways via bark or needles. Levels of lead-in-wood (up to 38mgkg(-1)) are at the upper end of those previously reported. There is evidence of radial translocation of lead towards the heartwood and variability in intra-site dendrochemical records. Mean site lead-in-wood records can however be related to a well-documented pollution chronology and also suggest the importance of local topography in the dispersal and deposition of particulate lead. This study demonstrates that P. sylvestris can be used to estimate the scale and timing of past pollution episodes in similar environmental contexts to those investigated at Darley Dale, where precisely dated pollution chronologies are lacking.

  19. Estudio geoeléctrico en el valle alto del Rio Patía

    Directory of Open Access Journals (Sweden)

    Pérez Cerón Rosalbina

    1995-10-01

    Full Text Available

    The resistivity survey carried out at the upper valley of the Patía River, provided good information to define the sedimentary sequence of the area. A general sequence from top to base is described as follows: recent deposits with resistivity values between 20 and 400 Ohrn-m, fine to medium grain, sandstones with resistivity values between 20 and 70 Ohrn-m, fine grain sandstones and silstones with resistivity values between 8 and 20 Ohrn-rn, and clayli basement, with resistivity less than 20 Ohm-m. There are two kinds of aquifers; free, related to sands and gravels from alluvial fans and terraces (resistivity values between 70 and 400 Ohrn-m and thickness between 25 and 75, semi-confined related to tertiary sandstones (resistivities values between 20 and 30 Ohm-m, thickness between 35 and 150 m. The water quality of the upper aquifers is good enough with small amounts of salt content. Saline water is found at the lower aquifer.

    The resistivity method was useful to locate geological discontinuities; some of them found with surface expression associated with lineaments and faults. Some of these geological features have been mapped in previous geological works on the area. In general the interpretation based on the resistivity results shows a block tectonics environment affecting cretaceous and tertiary rocks and probably the quaternary deposit.

    La prospección eléctrica en el valle alto del Rio Patía, permitió definir una secuencia típica constituida de techo a base por

  20. Effect of two Howard Hughes Medical Institute research training programs for medical students on the likelihood of pursuing research careers.

    Science.gov (United States)

    Fang, Di; Meyer, Roger E

    2003-12-01

    To assess the effect of Howard Hughes Medical Institute's (HHMI) two one-year research training programs for medical students on the awardees' research careers. Awardees of the HHMI Cloister Program who graduated between 1987 and 1995 and awardees of the HHMI Medical Fellows Program who graduated between 1991 and 1995 were compared with unsuccessful applicants to the programs and MD-PhD students who graduated during the same periods. Logistic regression analyses were conducted to assess research career outcomes while controlling for academic and demographic variables that could affect selection to the programs. Participation in both HHMI programs increased the likelihood of receiving National Institutes of Health postdoctoral support. Participation in the Cloister Program also increased the likelihood of receiving a faculty appointment with research responsibility at a medical school. In addition, awardees of the Medical Fellows Program were not significantly less likely than Medical Scientist Training Program (MSTP) and non-MSTP MD-PhD program participants to receive a National Institutes of Health postdoctoral award, and awardees of the Cloister Program were not significantly less likely than non-MSTP MD-PhD students to receive a faculty appointment with research responsibility. Women and underrepresented minority students were proportionally represented among awardees of the two HHMI programs whereas they were relatively underrepresented in MD-PhD programs. The one-year intensive research training supported by the HHMI training programs appears to provide an effective imprinting experience on medical students' research careers and to be an attractive strategy for training physician-scientists.

  1. Raman spectroscopy as a PAT for pharmaceutical blending: Advantages and disadvantages.

    Science.gov (United States)

    Riolo, Daniela; Piazza, Alessandro; Cottini, Ciro; Serafini, Margherita; Lutero, Emilio; Cuoghi, Erika; Gasparini, Lorena; Botturi, Debora; Marino, Iari Gabriel; Aliatis, Irene; Bersani, Danilo; Lottici, Pier Paolo

    2018-02-05

    Raman spectroscopy has been positively evaluated as a tool for the in-line and real-time monitoring of powder blending processes and it has been proved to be effective in the determination of the endpoint of the mixing, showing its potential role as process analytical technology (PAT). The aim of this study is to show advantages and disadvantages of Raman spectroscopy with respect to the most traditional HPLC analysis. The spectroscopic results, obtained directly on raw powders, sampled from a two-axis blender in real case conditions, were compared with the chromatographic data obtained on the same samples. The formulation blend used for the experiment consists of active pharmaceutical ingredient (API, concentrations 6.0% and 0.5%), lactose and magnesium stearate (as excipients). The first step of the monitoring process was selecting the appropriate wavenumber region where the Raman signal of API is maximal and interference from the spectral features of excipients is minimal. Blend profiles were created by plotting the area ratios of the Raman peak of API (A API ) at 1598cm -1 and the Raman bands of excipients (A EXC ), in the spectral range between 1560 and 1630cm -1 , as a function of mixing time: the API content can be considered homogeneous when the time-dependent dispersion of the area ratio is minimized. In order to achieve a representative sampling with Raman spectroscopy, each sample was mapped in a motorized XY stage by a defocused laser beam of a micro-Raman apparatus. Good correlation between the two techniques has been found only for the composition at 6.0% (w/w). However, standard deviation analysis, applied to both HPLC and Raman data, showed that Raman results are more substantial than HPLC ones, since Raman spectroscopy enables generating data rich blend profiles. In addition, the relative standard deviation calculated from a single map (30 points) turned out to be representative of the degree of homogeneity for that blend time. Copyright © 2017

  2. Efectos del agua ozonizada sobre microorganismos patógenos y alterantes de frutas y hortalizas

    Directory of Open Access Journals (Sweden)

    Laura Frisón

    2013-01-01

    Full Text Available La demanda de productos mínimamente procesados es creciente. Su inocuidad es un tema que preocupa tanto a procesadores, como a agencias de regulación y a consumidores. Las industrias han tenido que buscar métodos más eficaces para evitar el deterioro por microorganismos y mejorar la vida útil. Se considera que una sanitización es segura si el sanitizante logra reducir 5 log (99,999 % eficiencia la concentración de bacterias y 4 log (99,99 % eficiencia la concentración de mohos. Se estudió el efecto del agua ozonizada sobre bacterias patógenas como Bacillus cereus, Pseudomonas sp., Escherichia coli, Sthaphylococcus aureus y Salmonella sp. y sobre hongos fitopatógenos, micotoxigénicos y alterantes de frutas y hortalizas como Aspergillus niger, Penicillium digitatum, Alternaria alternata y Cladosporium cladosporioides.Se realizaron ensayos in vitro mediante el Test de Suspensión a 2 concentraciones de ozono en agua y 4 tiempos de exposición. Se logró determinar el siguiente orden descendente de resistencia en bacterias: B. cereus, Pseudomonas sp., E. coli, S. aureus y Salmonella sp. Se logró determinar el siguiente orden descendente de resistencia en mohos: A. niger, P. digitatum, A. alternata y C. cladosporioides. Se realizaron ensayos sobre hojas de lechuga, que contenían inoculadas las bacterias en estudio, con agua ozonizada ([2 ppm], por 5 minutos y sobre naranjas enteras, que contenían inoculadas conidios de los mohos en estudio, con agua ozonizada ([3 ppm], por 15 minutos. En ninguno de los ensayos se logró reducir más de 3 log la concentración de microorganismos. Teniendo en cuenta que las altas concentraciones de microorganismos inoculados en los ensayos (10E6 - 10E7 células/mL para bacterias y 10E5 - 10E6 conidios/mL para mohos no se encuentran normalmente en estos alimentos frescos, se puede inferir que el ozono podría utilizarse como sanitizante.

  3. Efectos del agua ozonizada sobre microorganismos patógenos y alterantes de frutas y hortalizas

    Directory of Open Access Journals (Sweden)

    Laura Frisón

    2013-06-01

    Full Text Available La demanda de productos mínimamente procesados es creciente. Su inocuidad es un tema que preocupa tanto a procesadores, como a agencias de regulación y a consumidores. Las industrias han tenido que buscar métodos más eficaces para evitar el deterioro por microorganismos y mejorar la vida útil. Se considera que una sanitización es segura si el sanitizante logra reducir 5 log (99,999 % eficiencia la concentración de bacterias y 4 log (99,99 % eficiencia la concentración de mohos. Se estudió el efecto del agua ozonizada sobre bacterias patógenas como Bacillus cereus, Pseudomonas sp., Escherichia coli, Sthaphylococcus aureus y Salmonella sp. y sobre hongos fitopatógenos, micotoxigénicos y alterantes de frutas y hortalizas como Aspergillus niger, Penicillium digitatum, Alternaria alternata y Cladosporium cladosporioides. Se realizaron ensayos in vitro mediante el Test de Suspensión a 2 concentraciones de ozono en agua y 4 tiempos de exposición. Se logró determinar el siguiente orden descendente de resistencia en bacterias: B. cereus, Pseudomonas sp., E. coli, S. aureus y Salmonella sp. Se logró determinar el siguiente orden descendente de resistencia en mohos:A. niger, P. digitatum, A. alternata y C. cladosporioides. Se realizaron ensayos sobre hojas de lechuga, que contenían inoculadas las bacterias en estudio, con agua ozonizada ([2 ppm], por 5 minutos y sobre naranjas enteras, que contenían inoculadas conidios de los mohos en estudio, con agua ozonizada ([3 ppm], por 15 minutos. En ninguno de los ensayos se logró reducir más de 3 log la concentración de microorganismos. Teniendo en cuenta que las altas concentraciones de microorganismos inoculados en los ensayos (106 - 107 células/mL para bacterias y 105 - 106 conidios/mL para mohos no se encuentran normalmente en estos alimentos frescos, se puede inferir que el ozono podría utilizarse como sanitizante.

  4. Review of the High Performance Antiproton Trap (HiPAT) Experiment at the Marshall Space Flight Center

    Science.gov (United States)

    Pearson, J. B.; Sims, Herb; Martin, James; Chakrabarti, Suman; Lewis, Raymond; Fant, Wallace

    2003-01-01

    The significant energy density of matter-antimatter annihilation is attractive to the designers of future space propulsion systems, with the potential to offer a highly compact source of power. Many propulsion concepts exist that could take advantage of matter-antimatter reactions, and current antiproton production rates are sufficient to support basic proof-of-principle evaluation of technology associated with antimatter- derived propulsion. One enabling technology for such experiments is portable storage of low energy antiprotons, allowing antiprotons to be trapped, stored, and transported for use at an experimental facility. To address this need, the Marshall Space Flight Center's Propulsion Research Center is developing a storage system referred to as the High Performance Antiproton Trap (HiPAT) with a design goal of containing 10(exp 12) particles for up to 18 days. The HiPAT makes use of an electromagnetic system (Penning- Malmberg design) consisting of a 4 Telsa superconductor, high voltage electrode structure, radio frequency (RF) network, and ultra high vacuum system. To evaluate the system normal matter sources (both electron guns and ion sources) are used to generate charged particles. The electron beams ionize gas within the trapping region producing ions in situ, whereas the ion sources produce the particles external to the trapping region and required dynamic capture. A wide range of experiments has been performed examining factors such as ion storage lifetimes, effect of RF energy on storage lifetime, and ability to routinely perform dynamic ion capture. Current efforts have been focused on improving the FW rotating wall system to permit longer storage times and non-destructive diagnostics of stored ions. Typical particle detection is performed by extracting trapped ions from HiPAT and destructively colliding them with a micro-channel plate detector (providing number and energy information). This improved RF system has been used to detect various

  5. Safety evaluation of the phosphinothricin acetyltransferase proteins encoded by the pat and bar sequences that confer tolerance to glufosinate-ammonium herbicide in transgenic plants.

    Science.gov (United States)

    Hérouet, Corinne; Esdaile, David J; Mallyon, Bryan A; Debruyne, Eric; Schulz, Arno; Currier, Thomas; Hendrickx, Koen; van der Klis, Robert-Jan; Rouan, Dominique

    2005-03-01

    Transgenic plant varieties, which are tolerant to glufosinate-ammonium, were developed. The herbicide tolerance is based upon the presence of either the bar or the pat gene, which encode for two homologous phosphinothricin acetyltransferases (PAT), in the plant genome. Based on both a review of published literature and experimental studies, the safety assessment reviews the first step of a two-step-approach for the evaluation of the safety of the proteins expressed in plants. It can be used to support the safety of food or feed products derived from any crop that contains and expresses these PAT proteins. The safety evaluation supports the conclusion that the genes and the donor microorganisms (Streptomyces) are innocuous. The PAT enzymes are highly specific and do not possess the characteristics associated with food toxins or allergens, i.e., they have no sequence homology with any known allergens or toxins, they have no N-glycosylation sites, they are rapidly degraded in gastric and intestinal fluids, and they are devoid of adverse effects in mice after intravenous administration at a high dose level. In conclusion, there is a reasonable certainty of no harm resulting from the inclusion of the PAT proteins in human food or in animal feed.

  6. An Application of X-ray Fluorescence as Process Analytical Technology (PAT) to Monitor Particle Coating Processes.

    Science.gov (United States)

    Nakano, Yoshio; Katakuse, Yoshimitsu; Azechi, Yasutaka

    2018-03-30

    An attempt to apply X-ray Fluorescence (XRF) analysis to evaluate small particle coating process as a Process Analytical Technologies (PAT) was made. The XRF analysis was used to monitor coating level in small particle coating process with at-line manner. The small particle coating process usually consists of multiple coating processes. This study was conducted by a simple coating particles prepared by first coating of a model compound (DL-methionine) and second coating by talc on spherical microcrystalline cellulose cores. The particles with two layered coating are enough to demonstrate the small particle coating process. From the result by the small particle coating process, it was found that the XRF signal played different roles, resulting that XRF signals by first coating (layering) and second coating (mask coating) could demonstrate the extent with different mechanisms for the coating process. Furthermore, the particle coating of the different particle size has also been investigated to evaluate size effect of these coating processes. From these results, it was concluded that the XRF could be used as a PAT in monitoring particle coating processes and become powerful tool in pharmaceutical manufacturing.

  7. Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach

    Directory of Open Access Journals (Sweden)

    Roberta Noberini

    2016-06-01

    Full Text Available Aberrant histone post-translational modifications (hPTMs have been implicated with various pathologies, including cancer, and may represent useful epigenetic biomarkers. The data described here provide a mass spectrometry-based quantitative analysis of hPTMs from formalin-fixed paraffin-embedded (FFPE tissues, from which histones were extracted through the recently developed PAT-H-MS method. First, we analyzed FFPE samples from mouse spleen and liver or human breast cancer up to six years old, together with their corresponding fresh frozen tissue. We then combined the PAT-H-MS approach with a histone-focused version of the super-SILAC strategy-using a mix of histones from four breast cancer cell lines as a spike-in standard- to accurately quantify hPTMs from breast cancer specimens belonging to different subtypes. The data, which are associated with a recent publication (Pathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples (Noberini, 2015 [1], are deposited at the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier http://www.ebi.ac.uk/pride/archive/projects/PXD002669.

  8. From Wireless Sensor Networks to Wireless Body Area Networks: Formal Modeling and Verification on Security Using PAT

    Directory of Open Access Journals (Sweden)

    Tieming Chen

    2016-01-01

    Full Text Available Model checking has successfully been applied on verification of security protocols, but the modeling process is always tedious and proficient knowledge of formal method is also needed although the final verification could be automatic depending on specific tools. At the same time, due to the appearance of novel kind of networks, such as wireless sensor networks (WSN and wireless body area networks (WBAN, formal modeling and verification for these domain-specific systems are quite challenging. In this paper, a specific and novel formal modeling and verification method is proposed and implemented using an expandable tool called PAT to do WSN-specific security verification. At first, an abstract modeling data structure for CSP#, which is built in PAT, is developed to support the node mobility related specification for modeling location-based node activity. Then, the traditional Dolev-Yao model is redefined to facilitate modeling of location-specific attack behaviors on security mechanism. A throughout formal verification application on a location-based security protocol in WSN is described in detail to show the usability and effectiveness of the proposed methodology. Furthermore, also a novel location-based authentication security protocol in WBAN can be successfully modeled and verified directly using our method, which is, to the best of our knowledge, the first effort on employing model checking for automatic analysis of authentication protocol for WBAN.

  9. Human induced discharge diversion in a tropical delta and its environmental implications: The Patía River, Colombia

    Science.gov (United States)

    Restrepo, Juan D.; Kettner, Albert

    2012-03-01

    SummaryThe Patía River, the number one in terms of sediment yield ˜1500 t km-2 yr-1 draining the western South America, has the most extensive and well developed delta on the Pacific coast, measuring 1700 km2. During the Holocene, nature forced the Patía delta to the south; however, a major water diversion, starting in 1972, diverted the Patía flow to the Sanguianga River, the latter, a small stream draining internal lakes from the Pacific lowlands. This human induced discharge diversion shifted the active delta plain back to the north and changed the northern estuarine system into an active delta plain. Overall, major environmental consequences of this discharge diversion in terms of morphological changes along the delta coast and distributary channels, are evidenced by: (1) coastal retreat along the abandoned delta lobe; 63% of the southern shoreline is retreating at maximum rates of 7 m yr-1, with a corresponding coastal land loss of 106 m yr-1; (2) transgressive barrier islands with exposed peat soils in the surf zone; (3) abandonment of former active distributaries in the southern delta plain with associated closing of inlets and formation of ebb tidal deltas; (4) breaching events on barrier islands; and (5) distributary channel accretion in the northern delta plain by morphological processes such as sedimentation (also in crevasses), overbank flow, increasing width of levees, interdistributary channel fill, and colonization of pioneer mangrove. The Sanguianga Mangrove National Park (SMNP), the largest mangrove reserve in Colombia, measuring 800 km2, lies in this former estuary, where major hydrologic and sedimentation changes are occurring. Observed environmental changes in the SMNP, include (1) seaward advance of the sub-aqueous delta front at the Sanquianga inlet evidenced by an increase in tidal flat area from 5.4 Mm2 in 1986 to 14 Mm2 in 2001; (2) freshening conditions in the Sanguianga distributary channel, a hydrologic change that has shifted the

  10. TERRAIN, HOWARD COUNTY, IA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix M: Data Capture Standards, describes the digital topographic data that was used to create...

  11. Mark report satellite tags (mrPATs) to detail large-scale horizontal movements of deep water species: First results for the Greenland shark (Somniosus microcephalus)

    Science.gov (United States)

    Hussey, Nigel E.; Orr, Jack; Fisk, Aaron T.; Hedges, Kevin J.; Ferguson, Steven H.; Barkley, Amanda N.

    2018-04-01

    The deep-sea is increasingly viewed as a lucrative environment for the growth of resource extraction industries. To date, our ability to study deep-sea species lags behind that of those inhabiting the photic zone limiting scientific data available for management. In particular, knowledge of horizontal movements is restricted to two locations; capture and recapture, with no temporal information on absolute animal locations between endpoints. To elucidate the horizontal movements of a large deep-sea fish, a novel tagging approach was adopted using the smallest available prototype satellite tag - the mark-report pop-up archival tag (mrPAT). Five Greenland sharks (Somniosus microcephalus) were equipped with multiple mrPATs as well as a standard archival satellite tag (miniPAT) that were programmed to release in sequence at 8-10 day intervals. The performance of the mrPATs was quantified. The tagging approach provided multiple locations per individual and revealed a previously unknown directed migration of Greenland sharks from the Canadian high Arctic to Northwest Greenland. All tags reported locations, however, the accuracy and time from expected release were variable among tags (average time to an accurate location from expected release = 30.8 h, range: 4.9-227.6 h). Average mrPAT drift rate estimated from best quality messages (LQ1,2,3) was 0.37 ± 0.09 m/s indicating tags were on average 41.1 ± 63.4 km (range: 6.5-303.1 km) from the location of the animal when they transmitted. mrPATs provided daily temperature values that were highly correlated among tags and with the miniPAT (70.8% of tag pairs were significant). In contrast, daily tilt sensor data were variable among tags on the same animal (12.5% of tag pairs were significant). Tracking large-scale movements of deep-sea fish has historically been limited by the remote environment they inhabit. The current study provides a new approach to document reliable coarse scale horizontal movements to understand

  12. Técnicas moleculares para la detección e identificación de patógenos en alimentos: ventajas y limitaciones

    OpenAIRE

    Palomino-Camargo, Carolina; González-Muñoz, Yuniesky

    2014-01-01

    Las enfermedades transmitidas por alimentos, ocasionadas por microorganismos patógenos, constituyen un grave problema de salud pública a nivel mundial. Los métodos microbiológicos utilizados comúnmente en la detección de estos patógenos, de origen alimentario, son laboriosos y consume mucho tiempo. Esta situación, aunada a la demanda por resultados inmediatos y a los avances tecnológicos, ha conducido al desarrollo de una amplia gama de métodos rápidos en las últimas décadas. En base a esto, ...

  13. Testing Timescales for Rhythms Recorded in the 2.5 Ga Banded Iron Formation of the Dales Gorge Member (Brockman Iron Formation, Hamersley Group, Australia)

    Science.gov (United States)

    Hinnov, L. A.; de Oliveira Carvalho Rodrigues, P.; Franco, D.

    2017-12-01

    The classic, Superior-type banded iron formation (BIF) of the Precambrian Dales Gorge Member (DGM) of the Brockman Iron Formation, Hamersley Basin, Western Australia consists of a succession of micro- (millimeter-scale) and meso- (centimeter to decimeter-scale) bands of primarily iron-silica chemical sediment alternations, separated into macro- (meter to decameter-scale) bands by shales (1). Here, we present a time-frequency analysis of a gray-scale scan of the DGM "type section core" Hole 47A with small contributions from Hole EC10 (1) to provide a comprehensive characterization of banding patterns and periodicity throughout the 140 m section. SHRIMP zircon ages (2) indicate that the DGM was deposited over approximately 30 myr during the Archean-Proterozoic transition just prior to the Great Oxidation Event. This suggests that the banding patterns recorded Milankovitch cycles, although with orbital-rotational parameters significantly different from present-day due to Earth's tidal dissipation and chaotic episodes in the Solar System since 2.5 Ga. Banding patterns change systematically within the formation in response to slowly varying environmental conditions, which have been interpreted previously to be related to sea level change and basin evolution (3). Researchers, including (2), have questioned the 30 myr duration, suggesting instead that the micro-bands may be annual in scale. This would indicate a much shorter duration of less than 150 kyr for the DGM. In an attempt to determine whether Milankovitch cycles could have generated the meso-band patterns, we present detailed studies of BIF0 and BIF12, which typify the marked changes in meso-banding along the section. Objective procedures are also applied, including ASM (4) and TIMEOPT (5) to test for a range of potential alternative timescales assuming orbital-rotational parameter values modeled for 2.5 Ga. References: (1) Trendall, A.K., Blockley, J.G., GSWA Ann. Rep. 1967, 48, 1968; (2) Trendall, A.K., et al

  14. Sulfur isotopes of host strata for Howards Pass (Yukon–Northwest Territories) Zn-Pb deposits implicate anaerobic oxidation of methane, not basin stagnation

    Science.gov (United States)

    Johnson, Craig A.; Slack, John F.; Dumoulin, Julie A.; Kelley, Karen Duttweiler; Falck, Hendrik

    2018-01-01

    A new sulfur isotope stratigraphic profile has been developed for Ordovician-Silurian mudstones that host the Howards Pass Zn-Pb deposits (Canada) in an attempt to reconcile the traditional model of a stagnant euxinic basin setting with new contradictory findings. Our analyses of pyrite confirm the up-section 34S enrichment reported previously, but additional observations show parallel depletion of carbonate 13C, an increase in organic carbon weight percent, and a change in pyrite morphology. Taken together, the data suggest that the 34S enrichment reflects a transition in the mechanism of pyrite formation during diagenesis, not isotopic evolution of a stagnant water mass. Low in the stratigraphic section, pyrite formed mainly in the sulfate reduction zone in association with organic matter–driven bacterial sulfate reduction. In contrast, starting just below the Zn-Pb mineralized horizon, pyrite formed increasingly within the sulfate-methane transition zone in association with anaerobic oxidation of methane. Our new insights on diagenesis have implications for (1) the setting of Zn-Pb ore formation, (2) the reliability of redox proxies involving metals, and (3) the source of ore sulfur for Howards Pass, and potentially for other stratiform Zn-Pb deposits contained in carbonaceous strata.

  15. Dāvināšana kā patērēšanas kultūras iezīme. Parfimērijas iegādes ietekmējošie faktori

    OpenAIRE

    Liepiņa, Krista

    2016-01-01

    Bakalaura darba “Dāvināšana kā patērēšanas kultūras iezīme. Parfimērijas iegādes ietekmējošie faktori” mērķis ir izpētīt, kas ir patērēšana un kas ietekmē patērētāju uzvedību ikdienā, kā arī svētku laikā, lēmuma pieņemšanas procesā, izvēloties preces dāvināšanas mērķim, nevis personīgai lietošanai. Darba teorētiskajā daļā apskatītas tādu jēdzienu teorētiskie aspekti kā patērēšana un patērniecība, patērēšanas kultūra, patērētāju uzvedība, patērētāju identitāte, kā arī tiek apskatīta dāvanu dāv...

  16. Impacto do Programa Água para Todos (PAT sobre a morbi-mortalidade por diarreia em crianças do Estado da Bahia, Brasil Impacto del Programa Agua para Todos (PAT sobre la morbimortalidad por diarrea en niños del Estado de Bahía, Brasil Impact of the Water for All Program (PAT on childhood morbidity and mortality from diarrhea in the Bahia State, Brazil

    Directory of Open Access Journals (Sweden)

    Davide Rasella

    2013-01-01

    Full Text Available O objetivo do presente estudo foi avaliar o impacto do Programa Água para Todos (PAT, implantado no Estado da Bahia, Brasil, por ampliar a cobertura do saneamento básico em áreas de maior vulnerabilidade. Foram selecionados 224 municípios com informações vitais adequadas. Foi utilizado um desenho de estudo antes-e-depois controlado, efetuando uma análise de regressão multivariada para dados em painel com resposta binomial negativa a efeitos fixos do ano 2005 até 2008. A cobertura do PAT, como variável contínua, esteve associada negativamente (p El objetivo del presente estudio fue evaluar el impacto del Programa Agua para Todos (PAT, implantado en el Estado de Bahía, Brasil, para ampliar la cobertura del saneamiento básico en áreas de mayor vulnerabilidad. Fueron seleccionados 224 municipios con información vital adecuada. Se utilizó un diseño de estudio antes-después controlado, efectuando un análisis de regresión multivariada para los datos en panel con respuesta binomial negativa, a efectos fijos del año 2005 hasta el 2008. La cobertura del PAT, como variable continua, estuvo asociada negativamente (p This study aimed to evaluate the impact of the Water for All Program (PAT, launched in Bahia State, Brazil, with the objective of expanding coverage of the water supply and sanitation in areas with high vulnerability to waterborne diseases. A total of 224 municipalities (counties with adequate vital statistics were selected. A controlled before-and-after study design was used, performing analyses with multivariate negative binomial regression with fixed effects, from 2005 to 2008. PAT coverage - as a continuous variable - was negatively associated (p < 0.01 with the under-five mortality rate. Municipalities with coverage ≥ 10% showed a reduction of 39% (p < 0.05 in mortality from diarrhea, under-five mortality of 14% (p < 0.01, and hospitalizations from diarrhea of 6% (p < 0.05 when compared to municipalities without PAT

  17. Strategic framework for education and training in Quality by Design (QbD) and process analytical technology (PAT)

    DEFF Research Database (Denmark)

    de Matas, Marcel; De Beer, Thomas; Folestad, Staffan

    2016-01-01

    is not prescriptive and is not aimed at describing specific course content in detail. It should however be used as a point of reference for those institutions delivering pharmaceutical based educational courses, to ensure that the necessary skills, knowledge and experience for successful pharmaceutical development...... advanced science and technology coupled with the application of modern Quality by Design (QbD) principles. In order that Europe keeps pace with these changes and sustains its position as major player in the development and commercialization of medicines, it is essential that measures are put in place...... to maintain a highly skilled workforce. A number of challenges however exist to equipping academic, industrial and health agency staff with the requisite knowledge, skills and experience to develop the next generation of medicines. In this regard, the EUFEPS QbD and PAT Sciences Network has proposed...

  18. Anotaciones sobre el Clima de los Bosques de Guandal del Delta del Río Patía

    Directory of Open Access Journals (Sweden)

    Del Valle Arango Jorge Ignacio

    1994-09-01

    Full Text Available Este ensayo intenta describir el clima del litoral Pacifico sur colombiano de una manera más precisa y empleando un cúmulo mayor de registros que en otros trabajos anteriores. Con esta base se realiza una clasificación bioclimática para los bosques de guandal del delta del río Patía. En cuanto a la lluvia se hace énfasis no sólo en los promedios mensuales y anuales sino en su oscilación y desviaciones estándar con el fin de evidenciar lo variable de tan importante factor climático. Finalmente se elaboran isoyetas para la región las cuales consideramos consistentes con la información disponible.

  19. Prevenção da transmissão de patógenos por manipuladores de alimentos

    Directory of Open Access Journals (Sweden)

    Mirza de Souza Conceição

    2015-03-01

    Full Text Available O objetivo desta pesquisa foi investigar as formas de prevenção da transmissão de patógeno por manipuladores de alimentos. Este trabalho utilizou uma abordagem qualitativa, mediante uma pesquisa bibliográfica, utilizando dados secundários oriundos de publicações e resultados de pesquisas específicas sobre o assunto realizando uma síntese explicativa sobre a prevenção da transmissão de patógenos por manipuladores de alimentos. As doenças transmitidas por alimentos é uma preocupação de saúde pública a nível mundial. E dentre agentes mais frequentes causadores de DTA’s estão os microrganismos de origem bacteriana como, a Salmonella spp, Escherichia coli, Staphylococcus aureus, Shigella spp, Bacillus cereus e Clostridium perfringens e destacam-se os alimentos de origem animal. Cabe destacar que a maioria dos manipuladores de alimentos necessita de maiores informações relacionadas à qualidade higiênica sanitária durante a fabricação dos produtos, e uma das maneiras de fornecer alimentos seguros é a realização de programas de educação continuada para esses profissionais. Conclui-se que o treinamento dos manipuladores de alimentos ainda é a melhor forma de contribuir para que estas pessoas se conscientizem sobre a sua responsabilidade e tenham cuidado no processamento do alimento.

  20. Strategic framework for education and training in Quality by Design (QbD) and process analytical technology (PAT).

    Science.gov (United States)

    de Matas, Marcel; De Beer, Thomas; Folestad, Staffan; Ketolainen, Jarkko; Lindén, Hans; Lopes, João Almeida; Oostra, Wim; Weimer, Marco; Öhrngren, Per; Rantanen, Jukka

    2016-07-30

    The regulatory and technical landscape of the pharmaceutical field is rapidly evolving from one focused predominantly on development of small molecules, using well established manufacturing technologies towards an environment in which biologicals and complex modalities are being developed using advanced science and technology coupled with the application of modern Quality by Design (QbD) principles. In order that Europe keeps pace with these changes and sustains its position as major player in the development and commercialization of medicines, it is essential that measures are put in place to maintain a highly skilled workforce. A number of challenges however exist to equipping academic, industrial and health agency staff with the requisite knowledge, skills and experience to develop the next generation of medicines. In this regard, the EUFEPS QbD and PAT Sciences Network has proposed a structured framework for education, training and continued professional development, which comprises a number of pillars covering the fundamental principles of modern pharmaceutical development including the underpinning aspects of science, engineering and technology innovation. The framework is not prescriptive and is not aimed at describing specific course content in detail. It should however be used as a point of reference for those institutions delivering pharmaceutical based educational courses, to ensure that the necessary skills, knowledge and experience for successful pharmaceutical development are maintained. A positive start has been made and a number of examples of formal higher education courses and short training programs containing elements of this framework have been described. The ultimate vision for this framework however, is to see widespread adoption and proliferation of this curriculum with it forming the backbone of QbD and PAT science based skills development. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. A Process Analytical Technology (PAT) approach to control a new API manufacturing process: development, validation and implementation.

    Science.gov (United States)

    Schaefer, Cédric; Clicq, David; Lecomte, Clémence; Merschaert, Alain; Norrant, Edith; Fotiadu, Frédéric

    2014-03-01

    Pharmaceutical companies are progressively adopting and introducing Process Analytical Technology (PAT) and Quality-by-Design (QbD) concepts promoted by the regulatory agencies, aiming the building of the quality directly into the product by combining thorough scientific understanding and quality risk management. An analytical method based on near infrared (NIR) spectroscopy was developed as a PAT tool to control on-line an API (active pharmaceutical ingredient) manufacturing crystallization step during which the API and residual solvent contents need to be precisely determined to reach the predefined seeding point. An original methodology based on the QbD principles was designed to conduct the development and validation of the NIR method and to ensure that it is fitted for its intended use. On this basis, Partial least squares (PLS) models were developed and optimized using chemometrics methods. The method was fully validated according to the ICH Q2(R1) guideline and using the accuracy profile approach. The dosing ranges were evaluated to 9.0-12.0% w/w for the API and 0.18-1.50% w/w for the residual methanol. As by nature the variability of the sampling method and the reference method are included in the variability obtained for the NIR method during the validation phase, a real-time process monitoring exercise was performed to prove its fit for purpose. The implementation of this in-process control (IPC) method on the industrial plant from the launch of the new API synthesis process will enable automatic control of the final crystallization step in order to ensure a predefined quality level of the API. In addition, several valuable benefits are expected including reduction of the process time, suppression of a rather difficult sampling and tedious off-line analyses. © 2013 Published by Elsevier B.V.

  2. Short-term effects of a dung pat on N2 fixation and total N uptake in a perennial ryegrass/white clover mixture

    DEFF Research Database (Denmark)

    Jørgensen, F.V.; Jensen, E.S.

    1997-01-01

    The short-term effects of a simulated cattle dung pat on N-2 fixation and total uptake of N in a perennial ryegrass/white clover mixture was studied in a container experiment using sheep faeces mixed with water to a DM content of 13%. We used a new N-15 cross-labelling technique to determine...

  3. Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes

    Directory of Open Access Journals (Sweden)

    Caroline Vindry

    2017-08-01

    Full Text Available Pat1 RNA-binding proteins, enriched in processing bodies (P bodies, are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer. Using co-immunoprecipitation and immunofluorescence approaches coupled with RNAi, we provide evidence for a nuclear complex of Pat1b with the Lsm2-8 heptamer, which binds to the spliceosomal U6 small nuclear RNA (snRNA. Furthermore, we establish the set of interactions connecting Pat1b/Lsm2-8/U6 snRNA/SART3 and additional U4/U6.U5 tri-small nuclear ribonucleoprotein particle (tri-snRNP components in Cajal bodies, the site of snRNP biogenesis. RNA sequencing following Pat1b depletion revealed the preferential upregulation of mRNAs normally found in P bodies and enriched in 3′ UTR AU-rich elements. Changes in >180 alternative splicing events were also observed, characterized by skipping of regulated exons with weak donor sites. Our data demonstrate the dual role of a decapping enhancer in pre-mRNA processing as well as in mRNA decay via distinct nuclear and cytoplasmic Lsm complexes.

  4. Colloidal Structure of Heavy Crudes and Asphaltene Soltutions Structure colloïdale des bruts lourds et des suspensions d'asphaltènes

    Directory of Open Access Journals (Sweden)

    Barre L.

    2006-12-01

    concentration fluctuations. It exists in the diluted suspension regions more or less extended, where the asphaltene concentration is greater than the average asphaltene concentration. Cryo-scanning electron microscopy has confirmed the system inhomogeneity. A two phase system was clearly highlighted. The flocculation process was followed during n-heptane addition by scattering measurements and microscopy observations. Small angle X-ray scattering (SAXS appears as a powerful tool for non-fractionated systems, as crude oil or other heavy derivatives. Density fluctuations were observed for a vacuum residue. L'industrie pétrolière est souvent confrontée a des problèmes industriels importants liés, entre autre, à la présence d'une forte concentration d'asphaltènes dans les fluides traités. Une meilleure connaissance de la composition de ces molécules et de l'évolution de leur structure colloïdale en solution ou dans leur milieu naturel est d'une grande importance pour mieux comprendre les mécanismes mis en jeu, et ainsi, pouvoir agir et limiter les problèmes rencontrés. Les asphaltènes correspondent à la fraction insoluble dans le n-heptane. Les molécules solubilisées dans l'alcane sont appelées maltènes et peuvent à leur tour être fractionnées par chromatographie en phase liquide; on obtient alors trois nouvelles fractions appelées résines, aromatiques et saturées. La plupart des travaux de recherche réalisés sur ces molécules complexes concernent la détermination de la composition chimique obtenue à l'aide de diverses techniques d'analyse telles la spectroscopie infrarouge et la résonance magnétique nucléaire. En revanche, peu d'informations sur la macrostructure colloïdale des asphaltènes sont disponibles dans la littérature. La détermination de la masse moléculaire a été le premier objectif : plusieurs méthodes, comme l'osmométrie à tension de vapeur, ont été appliquées. La conclusion principale de ces déterminations est la grande

  5. Efficacy and Safety of Tranexamic Acid in Prehospital Traumatic Hemorrhagic Shock: Outcomes of the Cal-PAT Study

    Directory of Open Access Journals (Sweden)

    Michael M. Neeki

    2017-04-01

    Full Text Available Introduction: The California Prehospital Antifibrinolytic Therapy (Cal-PAT study seeks to assess the safety and impact on patient mortality of tranexamic acid (TXA administration in cases of trauma-induced hemorrhagic shock. The current study further aimed to assess the feasibility of prehospital TXA administration by paramedics within the framework of North American emergency medicine standards and protocols. Methods: This is an ongoing multi-centered, prospective, observational cohort study with a retrospective chart-review comparison. Trauma patients identified in the prehospital setting with signs of hemorrhagic shock by first responders were administered one gram of TXA followed by an optional second one-gram dose upon arrival to the hospital, if the patient still met inclusion criteria. Patients administered TXA make up the prehospital intervention group. Control group patients met the same inclusion criteria as TXA candidates and were matched with the prehospital intervention patients based on mechanism of injury, injury severity score, and age. The primary outcomes were mortality, measured at 24 hours, 48 hours, and 28 days. Secondary outcomes measured included the total blood products transfused and any known adverse events associated with TXA administration. Results: We included 128 patients in the prehospital intervention group and 125 in the control group. Although not statistically significant, the prehospital intervention group trended toward a lower 24-hour mortality rate (3.9% vs 7.2% for intervention and control, respectively, p=0.25, 48-hour mortality rate (6.3% vs 7.2% for intervention and control, respectively, p=0.76, and 28-day mortality rate (6.3% vs 10.4% for intervention and control, respectively, p=0.23. There was no significant difference observed in known adverse events associated with TXA administration in the prehospital intervention group and control group. A reduction in total blood product usage was observed

  6. A Performance Prediction Method for Pumps as Turbines (PAT Using a Computational Fluid Dynamics (CFD Modeling Approach

    Directory of Open Access Journals (Sweden)

    Emma Frosina

    2017-01-01

    Full Text Available Small and micro hydropower systems represent an attractive solution for generating electricity at low cost and with low environmental impact. The pump-as-turbine (PAT approach has promise in this application due to its low purchase and maintenance costs. In this paper, a new method to predict the inverse characteristic of industrial centrifugal pumps is presented. This method is based on results of simulations performed with commercial three-dimensional Computational Fluid Dynamics (CFD software. Model results have been first validated in pumping mode using data supplied by pump manufacturers. Then, the results have been compared to experimental data for a pump running in reverse. Experimentation has been performed on a dedicated test bench installed in the Department of Civil Construction and Environmental Engineering of the University of Naples Federico II. Three different pumps, with different specific speeds, have been analyzed. Using the model results, the inverse characteristic and the best efficiency point have been evaluated. Finally, results have been compared to prediction methods available in the literature.

  7. The effectiveness of CPI model to improve positive attitude toward science (PATS) for pre-service physics teacher

    Science.gov (United States)

    Sunarti, T.; Wasis; Madlazim; Suyidno; Prahani, B. K.

    2018-03-01

    In the previous research, learning material based Construction, Production, and Implementation (CPI) model has been developed to improve scientific literacy and positive attitude toward science for pre-service physics teacher. CPI model has 4 phases, included: 1) Motivation; 2) Construction (Cycle I); 3) Production (Cycle II); and 4) Evaluation. This research is aimed to analyze the effectiveness of CPI model towards the improvement Positive Attitude toward Science (PATS) for pre-service physics teacher. This research used one group pre-test and post-test design on 160 pre-service physics teacher divided into 4 groups at Lambung Mangkurat University and Surabaya State University (Indonesia), academic year 2016/2017. Data collection was conducted through questioner, observation, and interview. Positive attitude toward science for pre-service physics teacher measurement were conducted through Positive Attitude toward Science Evaluation Sheet (PATSES). The data analysis technique was done by using Wilcoxon test and n-gain. The results showed that there was a significant increase in positive attitude toward science for pre-service physics teacher at α = 5%, with n-gain average of high category. Thus, the CPI model is effective for improving positive attitude toward science for pre-service physics teacher.

  8. [Status of diagnosis and treatment devices of acupuncture based on SooPAT and bibliometrics in China].

    Science.gov (United States)

    Bai, Lin; Ren, Yulan; Guo, Taipin; Chen, Lin; Zhou, Yumei; Feng, Shuwei; Li, Ji; Liang, Fanrong

    2016-11-12

    To perform a bibliometrics analysis on patent literature regarding diagnosis and treatment devices of acupuncture in China, aiming to provide references for the development of diagnosis and treatment devices of acupuncture. Based on SooPAT, a patent database, the patent literature regarding diagnosis and treatment devices of acupuncture in China was collected. With bibliometrics methods, the annual distribution of type, quantity, classification and content of diagnosis and treatment devices of acupuncture were analyzed. The number of acupuncture diagnosis and treatment devices reached its peak in 2012 and 2013 in China. The A61N in patent and utility model patent were the most, which were mainly related to electrotherapy, magnetic therapy, radioactive therapy and ultrasound therapy, etc. The main content was acupuncture treatment devices and meridian treatment devices. The 24-01 in design patent was the most, involving fixation devices used by doctors, hospitals and laboratories, etc. Currently the majority of diagnosis and treatment devices of acupuncture is therapeutic apparatus, while the acupuncture diagnosis devices are needed.

  9. Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production.

    Science.gov (United States)

    Langemann, Timo; Mayr, Ulrike Beate; Meitz, Andrea; Lubitz, Werner; Herwig, Christoph

    2016-01-01

    Flow cytometry (FCM) is a tool for the analysis of single-cell properties in a cell suspension. In this contribution, we present an improved FCM method for the assessment of E-lysis in Enterobacteriaceae. The result of the E-lysis process is empty bacterial envelopes-called bacterial ghosts (BGs)-that constitute potential products in the pharmaceutical field. BGs have reduced light scattering properties when compared with intact cells. In combination with viability information obtained from staining samples with the membrane potential-sensitive fluorescent dye bis-(1,3-dibutylarbituric acid) trimethine oxonol (DiBAC4(3)), the presented method allows to differentiate between populations of viable cells, dead cells, and BGs. Using a second fluorescent dye RH414 as a membrane marker, non-cellular background was excluded from the data which greatly improved the quality of the results. Using true volumetric absolute counting, the FCM data correlated well with cell count data obtained from colony-forming units (CFU) for viable populations. Applicability of the method to several Enterobacteriaceae (different Escherichia coli strains, Salmonella typhimurium, Shigella flexneri 2a) could be shown. The method was validated as a resilient process analytical technology (PAT) tool for the assessment of E-lysis and for particle counting during 20-l batch processes for the production of Escherichia coli Nissle 1917 BGs.

  10. Morfologia de Plântulas e Controle de Patógenos em Sementes de Cordia trichotoma

    Directory of Open Access Journals (Sweden)

    Álvaro Luis Pasquetti Berghetti

    Full Text Available O presente trabalho tem como objetivo descrever morfologicamente o desenvolvimento das plântulas de Cordia trichotoma, determinar a influência dos tratamentos de semente e do substrato na redução da incidência de patógenos, assim como avaliar o potencial germinativo das sementes. O teste de sanidade foi realizado em esquema bifatorial 2 × 4 (dois tipos de beneficiamento e quatro tratamentos de sementes. O teste de germinação representou um esquema trifatorial 2 × 4 × 3 (dois beneficiamentos, quatro tratamentos de sementes e três substratos. O início da germinação ocorreu no 18° dia após a instalação do teste. A germinação das sementes é do tipo epígea, com plântula fanerocotiledonar. O percentual germinativo das sementes é superior quando é retirado todo o perianto, independentemente do substrato utilizado e do tratamento. O tratamento com Captan® reduziu a incidência de fungos dos gêneros Alternaria spp., Trichoderma spp., Rhizopus spp.

  11. A PAT approach for the on-line monitoring of pharmaceutical co-crystals formation with near infrared spectroscopy.

    Science.gov (United States)

    Sarraguça, Mafalda C; Ribeiro, Paulo R S; Santos, Adenilson O; Silva, Marta C D; Lopes, João A

    2014-08-25

    Cocrystals represent a class of crystalline solids consisting of two or more molecular species usually held together by non-covalent bonds. Pharmaceutical cocrystals can alter the physicochemical properties of the active pharmaceutical ingredient to improve solubility, dissolution rate, particle properties and stability. This work presents a process analytical technology (PAT) approach to monitor on-line the cocrystallization of furosemide and adenine by solvent evaporation using near infrared spectroscopy (NIRS). Furosemide and adenine were added to a small volume of methanol in a beaker and stirred on an orbital stirring table during 8h at room temperature. The on-line monitoring was performed with a FT-NIR spectrometer fitted with a reflectance fiber optic probe. Monitoring was performed with the probe tip placed 1cm above the cocrystallization medium to avoid interference with the cocrystallization process. Cocrystals were vacuum dried to remove residual solvent and characterized off-line by NIRS, MIRS, DSC and XRPD. Results demonstrate that it was possible to follow the main cocrystallization events on-line. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Two Interlocked Triads in Pat Kinevane’s Recent Plays: Self-Soul-Conscousness and Birth-Death-Rebirth

    Directory of Open Access Journals (Sweden)

    Nicoleta Stanca

    2017-05-01

    Full Text Available Everyting conceivable, all that has ever been imagined, can be included in our minds and souls. As psyche means “breath”, “soul” and “mind”, it points to the relevance of psychology as a study of mental, emotional and spiritual processes involved in our identity make-up. One of the main organizers of our self and psychological experiences is our relationhip with death: our fear of abandonement and of being alone when conceiving our own death, the fear of the loss of the others, leading to the fear of attachment and emotional death. Pat Kinevane, a contemporary Irish playright, deals, in his 2005 play, Forgotten, with the idea of family and social abandonment of old people in nursing homes. The interconnected stories of Dora, Eucharia, Flor and Gustus, the characters in the play, aged 80-100 years old, living in separate retirement and care facilities around Ireland, reveal these fears. Mental illness in the current explosion of anxiety is also crucial to our identity. Another play by Kinevane, Silent (2010, ends with the word silent, which indicates the insanity, invisibility and ultimately the death of the protagonist, Tino McGoldring, a homeless man tormented by the suicide of his brother. His self after the loss of his brother, wife, family, job, mind is constructed in relation to the past and the imaginary world of the Italian-American icon of the film industry of the 1920s, Rudolph Valentino.

  13. [The Patient Rights Act (PatRG)--part 1: legislative procedure, treatment contract, contracting parties and their obligations to cooperate and inform].

    Science.gov (United States)

    Parzeller, Markus; Zedler, Barbara

    2013-01-01

    The article deals with the new regulations in the German Civil Code (BGB) which came into effect in Germany on 26 Feb 2013 as the Patient Rights Act (PatRG). In Part I, the legislative procedure, the treatment contract and the contracting parties (Section 630a Civil Code), the applicable regulations (Section 630b Civil Code) and the obligations to cooperate and inform (Section 630c Civil Code) are discussed and critically analysed.

  14. The proton-coupled amino acid transporter hPAT1 is the main transporter involved in vigabatrin uptake in intestinal Caco-2 cells

    DEFF Research Database (Denmark)

    Nøhr, Martha Kampp; Hansen, Steen Honore'; Brodin, Birger

    2012-01-01

    transporter hPAT1. The aim of the project was to identify if transporters are involved in cellular uptake of vigabatrin in Caco-2 cells. Methods: The uptake rate of vigabatrin was measured in Caco-2 cells at pH 6.0 or 7.4 for 15 min after application of 0.1 – 25.0 mM vigabatrin. The inhibitory effect...... of selected amino acids and -derivatives on the apical vigabatrin uptake in Caco-2 cells was investigated. Vigabatrin samples were analyzed using liquid chromatography (LC) coupled to a mass selective detector (MSD). Results: The uptake rate of vigabatrin in Caco-2 cells was pH-dependent. The uptake...... of vigabatrin was saturable at pH 6.0 with a Michaelis constant, Km of 12.7 ± 3.7 mM and a maximal flux, Jmax of 3.7 ± 0.5 nmol•min-1•cm-2. The presences of hPAT1 ligands significantly inhibited the uptake of vigabatrin in Caco-2 cells at pH 6.0, whereas hPAT1 non-ligands did not. Discussion: The saturability...

  15. The utilization of induction generators working with PATs (pumps working as turbines) in electric energy generation; A utilizacao de geradores de inducao acionados por BFTs (bombas funcionando como turbinas) na geracao de energia eletrica

    Energy Technology Data Exchange (ETDEWEB)

    Viana, Augusto Nelson Carvalho; Rezek, Angelo Jose Junqueira; Medeiros, Daniel de Macedo [Universidade Federal de Itajuba (UNIFEI), MG (Brazil). Programa de Pos-graduacao em Engenharia da Energia], e-mail: augusto@unifei.edu.br, e-mail: rezek@iee.efei.br, e-mail: macedo@unifei.edu.br

    2004-07-01

    The utilization of the Pumps working as Turbines (PATs) in micro hydro-energy resources to replace the conventional turbines as Pelton, Francis and Propeller have been used in countries as USA, Germany and France. In the mean time, in Brazil this practice and the utilization of induction generators working with PATs is still in the scope of the laboratory experiments. This work, based on experimental results carried on in Laboratory of Hydromechanics for Small Hydro Power Plants (Laboratorio Hidromecanico para Pequenas Centrais Hidroeletricas - LHPCH - UNIFEI), (VIANA, 1987), (VIANA e NOGUEIRA, 1990), propose the utilization of asynchronous generator groups operating with PATs. To show the investment cost decrease in micro hydro power plants (MHPs), is showed the Boa Esperanca MPH example, in which is presented a comparison between the synchronous generator group cost working with a Michell-Banki turbine and a asynchronous generator group operating with a PAT. (author)

  16. Genética de la resistencia de la papa (Solanum tuberosum a patógenos. Estado de arte

    Directory of Open Access Journals (Sweden)

    Mosquera Teresa

    2008-04-01

    Full Text Available

    Este artículo presenta una revisión de la resistencia en papa a patógenos, en cuanto a genes mapeados y clonados, y loci de rasgos cuantitativos (QTL mapeados, en la que se resaltan las relaciones entre resistencia cuantitativa y cualitativa en el caso P. infestans. El conocimiento logrado ha permitido generar un mapa funcional sobre el cual se localizan QTL para resistencia a patógenos. Se han mapeado 20 genes R de resistencia a virus, hongos, nematodos y oomicetos, utilizando marcadores moleculares. La mayoría de estos genes R fueron introducidos de especies silvestres. Catorce de ellos se encuentran en hot spots para resistencia y confieren resistencia a varios patógenos. A la fecha se han identificado cinco clusters de resistencia. La resistencia monogénica envuelve dos procesos básicos: percepción del ataque del patógeno, seguida de una respuesta para limitar la enfermedad. La percepción implica receptores específicos para cepas patogénicas, que son decodificadas por genes de resistencia. En una planta se encuentra un gran repertorio de genes de resistencia R, ubicados en diferentes sitios del genoma. Estos genes expresan diferentes proteínas que pueden ser agrupadas en varias familias. La mayoría de proteínas R contienen repeticiones en grupos, ricas en leucina (LRR. Se plantea la colocalización de genes R y QTL en diferentes cromosomas. Una hipótesis señala que los QTL son variantes alélicas con efecto menos extremo que los genes R y una segunda hipótesis plantea que los QTL de resistencia mapean en regiones del genoma que contienen genes de función conocida involucrados en la respuesta general al ataque de patógenos.

  17. Ação de herbicidas sobre mecanismos de defesa das plantas aos patógenos

    Directory of Open Access Journals (Sweden)

    Rizzardi Mauro Antônio

    2003-01-01

    Full Text Available As plantas necessitam defender-se continuamente do ataque de agentes biológicos e de estresses do ambiente. A imobilidade e a falta de sistema imunológico, como ocorre em animais, fizeram com que as plantas desenvolvessem mecanismos de defesa, em que cada célula possui tanto capacidade de defesa induzida quanto pré-formada. No entanto, esses mecanismos podem ser influenciados pelo uso de herbicidas. A presente revisão objetivou apresentar os efeitos de herbicidas em mecanismos de defesa das plantas contra patógenos, bem como analisar as possíveis conseqüências desse conhecimento no manejo de plantas daninhas e de culturas. Alguns herbicidas influenciam a severidade de doenças, induzindo ou inibindo a síntese de fitoalexinas. Herbicidas do grupo químico difeniléteres geram espécies reativas de oxigênio, as quais mediam a ativação de genes de defesa responsáveis pela síntese de fitoalexinas e também por reação de hipersensibilidade. O uso de subdoses de glyphosate ocasiona efeito contrário, diminuindo a produção de fitoalexinas e aumentando a severidade de doenças. A constatação desses efeitos requer a adoção de estratégias de manejo que minimizem seus impactos negativos ou que se beneficiem desses efeitos, como pode ocorrer quando do uso de bioherbicidas.

  18. Real-time determination of critical quality attributes using near-infrared spectroscopy: a contribution for Process Analytical Technology (PAT).

    Science.gov (United States)

    Rosas, Juan G; Blanco, Marcel; González, Josep M; Alcalà, Manel

    2012-08-15

    Process Analytical Technology (PAT) is playing a central role in current regulations on pharmaceutical production processes. Proper understanding of all operations and variables connecting the raw materials to end products is one of the keys to ensuring quality of the products and continuous improvement in their production. Near infrared spectroscopy (NIRS) has been successfully used to develop faster and non-invasive quantitative methods for real-time predicting critical quality attributes (CQA) of pharmaceutical granulates (API content, pH, moisture, flowability, angle of repose and particle size). NIR spectra have been acquired from the bin blender after granulation process in a non-classified area without the need of sample withdrawal. The methodology used for data acquisition, calibration modelling and method application in this context is relatively inexpensive and can be easily implemented by most pharmaceutical laboratories. For this purpose, Partial Least-Squares (PLS) algorithm was used to calculate multivariate calibration models, that provided acceptable Root Mean Square Error of Predictions (RMSEP) values (RMSEP(API)=1.0 mg/g; RMSEP(pH)=0.1; RMSEP(Moisture)=0.1%; RMSEP(Flowability)=0.6 g/s; RMSEP(Angle of repose)=1.7° and RMSEP(Particle size)=2.5%) that allowed the application for routine analyses of production batches. The proposed method affords quality assessment of end products and the determination of important parameters with a view to understanding production processes used by the pharmaceutical industry. As shown here, the NIRS technique is a highly suitable tool for Process Analytical Technologies. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. ENSINO ORIENTADO PELO RESPEITO ÀS INTELIGÊNCIAS MÚLTIPLAS: AS CONTRIBUIÇÕES DE HOWARD GARDNER PARA O EXERCÍCIO DA DOCÊNCIA

    Directory of Open Access Journals (Sweden)

    Kelly Roman Pavan

    2014-09-01

    Full Text Available A obra de Howard Gardner intitulada Inteligências múltiplas – A teoria na prática foi publicada no Brasil há quase vinte anos. Embora não se trate de obra recente, vale a pena revisitá-la com um olhar crítico e destacar suas importantes contribuições para o exercício da docência.

  20. Constants of the Alper and Howard-Flanders oxygen equation for damage to bacterial membrane, deduced from observations on the radiation-induced penicillin-sensitive lesion

    International Nuclear Information System (INIS)

    Obioha, F.I.; Gillies, N.E.; Cullen, B.M.; Walker, H.C.; Alper, T.

    1984-01-01

    E. coli were irradiated in the presence of 100% oxygen, oxygen-free nitrogen and mixtures of 1.01, 0.59, 0.3, 0.1 and 0.06% oxygen in nitrogen. Changes in sensitivity with pO 2 conformed with the Alper and Howard-Flanders equation for bacteria treated after irradiation by penicillin as well as for the untreated ones. Values of m were respectively 4.8 and 3.3; values of K were identical, within experimental error, (4.4 mmHg). Sensitivity to induction of the bacterial membrane penicillin-sensitive lesion was calculated from the difference in the reciprocals of D 0 values proper to untreated and treated bacteria, for every gas used. The value of m could not be directly calculated because the effect of penicillin on anoxically irradiated bacteria was not detectable. For that reason, a transformation of the oxygen equation was used, allowing estimates to be made of both m and K, provided the results conformed with the equation. Within experimental error they did. Calculated values of m and K for induction of the penicillin-sensitive lesion were respectively 8 and 5.9 mmHg, but it is shown that the oxygen enhancement ratio was probably underestimated and the value overestimated. (author)

  1. ‘Dirty work’, but someone has to do it: Howard P. Robertson and the refereeing practices of Physical Review in the 1930s

    Science.gov (United States)

    Lalli, Roberto

    2016-01-01

    In the 1930s the mathematical physicist Howard P. Robertson was the main referee of the journal Physical Review for papers concerning general relativity and related subjects. The rich correspondence between Robertson and the editors of the journal enables a historical investigation of the refereeing process of Physical Review at the time that it was becoming one of the most influential physics periodicals in the world. By focusing on this case study, the paper investigates two complementary aspects of the evolution of the refereeing process: first, the historical evolution of the refereeing practices in connection with broader contextual changes, and second, the attempts to define the activity of the referee, including the epistemic virtues required and the journal's functions according to the participants' categories. By exploring the tension between Robertson's idealized picture about how the referee should behave and the desire to promote his intellectual agenda, I show that the evaluation criteria that Robertson employed were contextually dependent and I argue that, in the 1930s, through his reports the referee had an enormous power in defining what direction future research should take. PMID:27386715

  2. Australia as America’s “Little Brother”: A Satiric Reading of John Howard in Andrew McGahan’s Underground

    Directory of Open Access Journals (Sweden)

    James Dahlstrom

    2016-12-01

    Full Text Available In this article, I read Andrew McGahan’s novel Underground as a criticism of the Australian government under the leadership of John Howard in the era following the September 11th attacks on the World Trade Center. I draw out the satire of Howard’s perceived role as President George W. Bush’s little brother, which becomes a synecdoche for Australia’s relationship with America. I situate the novel in the context of America’s cyclically neo-colonial history in Australia and draw upon the work of Homi K. Bhabha to suggest that McGahan portrays Australians as an “in-between” people who are guilty of adopting American policies—and thereby relinquishing control of their nation’s sovereignty to America—without compunction. I further suggest that, in the tradition of satire, the novel could be read as a warning to Australians against following the United State too closely. With the rise of the self-proclaimed Islamic State, Australia has witnessed the re-emergence of the political climate that is reflected in Underground, renewing its relevance to contemporary audiences.

  3. The Treatment of Acute Ankle Sprain by Acupuncture at Xiaojie and Daling Point Combined with Movement%针刺小节穴、大陵穴配合运动治疗急性踝关节扭伤

    Institute of Scientific and Technical Information of China (English)

    黄义专

    2015-01-01

    目的 观察针刺小节穴、大陵穴配合运动治疗急性踝关节扭伤的临床疗效. 方法 选择64例急性踝关节扭伤患者,随机分为2组(各组32例);对照组采用外敷新伤药治疗,观察组采用针刺小节穴、大陵穴配合运动治疗;记录前两次治疗前后、疗程结束时综合评分,采用统计学分析. 结果 观察组临床痊愈率为68. 75%,对照组临床痊愈率为37.50%;观察组疗程为(2.34 ±0.79)d,对照组疗程为(5.56 ±2.11)d;两组比较,临床痊愈率、疗程差异有统计学意义(P<0. 05). 结论 针刺小节穴、大陵穴配合运动治疗急性踝关节扭伤能较快改善症状、缩短疗程,远期疗效明显,值得临床推广.%Objective To observe the effects of acupuncture at Xiaojie and Daling point combined with movement in the treatment of acute ankle sprain. Methods 64 cases of patients with o acute ankle sprain were randomly divided into 2 groups (32 cases in each group);Patients of control group were treated with external application using Chinese drugs. Patients of observation group were treated with acupuncture at Xiaojie and Daling point combined with movement. Record the comprehensive score before and after treatment at the fist and the second and the last time, then analysied by SPSS19. 0. Results The clinical cure rate was 68. 75% in the observation group, the clinical cure rate is 37. 50% in the control group;the observation group course of treatment were 2. 34 ± 0. 79 days, the control group course of treatment were(5. 56 ± 2. 11)days; the data of two groups had significant difference with the clinical cure rate, and course of treatment (P<0. 05). Conclusion Acupuncture at Xiaojie and Daling point combined with movement can quickly improve symptoms, shorten the course of treatment of the patient with acute ankle sprain, and has a conspicuous long-term effect and is worthy of popularizing.

  4. On-line near infrared spectroscopy as a Process Analytical Technology (PAT) tool to control an industrial seeded API crystallization.

    Science.gov (United States)

    Schaefer, C; Lecomte, C; Clicq, D; Merschaert, A; Norrant, E; Fotiadu, F

    2013-09-01

    The final step of an active pharmaceutical ingredient (API) manufacturing synthesis process consists of a crystallization during which the API and residual solvent contents have to be quantified precisely in order to reach a predefined seeding point. A feasibility study was conducted to demonstrate the suitability of on-line NIR spectroscopy to control this step in line with new version of the European Medicines Agency (EMA) guideline [1]. A quantitative method was developed at laboratory scale using statistical design of experiments (DOE) and multivariate data analysis such as principal component analysis (PCA) and partial least squares (PLS) regression. NIR models were built to quantify the API in the range of 9-12% (w/w) and to quantify the residual methanol in the range of 0-3% (w/w). To improve the predictive ability of the models, the development procedure encompassed: outliers elimination, optimum model rank definition, spectral range and spectral pre-treatment selection. Conventional criteria such as, number of PLS factors, R(2), root mean square errors of calibration, cross-validation and prediction (RMSEC, RMSECV, RMSEP) enabled the selection of three model candidates. These models were tested in the industrial pilot plant during three technical campaigns. Results of the most suitable models were evaluated against to the chromatographic reference methods. Maximum relative bias of 2.88% was obtained about API target content. Absolute bias of 0.01 and 0.02% (w/w) respectively were achieved at methanol content levels of 0.10 and 0.13% (w/w). The repeatability was assessed as sufficient for the on-line monitoring of the 2 analytes. The present feasibility study confirmed the possibility to use on-line NIR spectroscopy as a PAT tool to monitor in real-time both the API and the residual methanol contents, in order to control the seeding of an API crystallization at industrial scale. Furthermore, the successful scale-up of the method proved its capability to be

  5. Gérmenes patógenos aislados en niños con infecciones respiratorias a repetición

    Directory of Open Access Journals (Sweden)

    Yoenny Peña García

    2015-01-01

    Full Text Available Las infecciones respiratorias agudas son la causa más frecuente de morbilidad y de elevada mortalidad en el mundo, particularmente en los países en desarrollo. Se realizó un estudio descriptivo de corte transversal, para caracterizar a los niños con infecciones respiratorias a repetición, según los gérmenes patógenos aislados, en el círculo infantil “Flores de la Vida” del municipio de Puerto Padre, en el período de abril a mayo de 2014. Se trabajó con los niños de los salones de segundo, tercero y cuarto año de vida, distribuidos según edad y sexo, a los que se les identificaron los gérmenes patógenos aislados en exudados nasofaríngeos. La información se obtuvo del departamento de microbiología del Centro Municipal de Higiene y Epidemiología. Se obtuvieron los siguientes resultados: el grupo de edad más frecuente fue el de dos años, que representó el 45 % de la muestra y se correspondió con la media de la edad. El 62,5 % de la muestra de estudio correspondió al sexo masculino. Los gérmenes patógenos aislados con mayor frecuencia fueron: el Streptococcus pneumoneae, para un 83,9 %, el Streptococcus B hemolítico, para un 7,1 % y el Haemophillus inflienzae para un 5,4 %

  6. Estudio comparativo entre aislados clínicos y no clínicos de S. cerevisiae y su papel como patógeno emergente.

    OpenAIRE

    Llanos Frutos, Rosa de

    2007-01-01

    RESUMEN La levadura Saccharomyces cerevisiae es la especie más utilizada desde un punto de vista biotecnológico. En la industria agroalimentaria interviene en la elaboración de pan y bebidas alcohólicas como el vino y la cerveza, además se emplea como suplemento dietético y como agente probiótico bajo el nombre de S. cerevisiae var. boulardii. A pesar de sus propiedades beneficiosas, S. cerevisiae se considera actualmente una levadura patógena oportunista emergente de baja virulencia, capa...

  7. Etnicidad, actores y territorio : luchas de los afrodescendientes de Patía y el Valle del Chota por el acceso a tierra y agua, 1990-2010

    OpenAIRE

    Angulo Balanta, Diana Patricia

    2013-01-01

    Esta investigación trata de entender, desde el paradigma de la identidad, las transformaciones en los procesos organizativos y construcción identitarias de las poblaciones afrodescendientes del Patía y El Valle del Chota. Este análisis aborda la incursión de este grupo social en el campo político, para establecer ante el Estado y la sociedad reivindicaciones de carácter redistributivo y de reconocimiento, a partir de la construcción de significados. Lo anterior implica determinar los factores...

  8. El colapso ambiental en el río Patía, Colombia: variaciones morfológicas y alteraciones en los ecosistemas de manglar

    Directory of Open Access Journals (Sweden)

    Adriana S Parra

    2014-03-01

    Full Text Available El delta del Patía ha experimentado grandes variaciones morfológicas en las últimas cuatro décadas debido a presiones antrópicas. El transvase del río Patía al río Sanquianga, debido a la construcción del canal Naranjo en 1973, y la posterior formación del brazo Patianga, han derivado en complejas problemáticas ambientales que se evidencian en la reactivación del lóbulo norte del delta y el abandono de la anterior desembocadura en el lóbulo sur. En este artículo se analizan las principales alteraciones que se presentan en el delta del Patía como producto del desvío del río y las consecuentes variaciones en el aporte fluvial y de sedimentos. Estas alteraciones se reflejan en: (1 cambios drásticos en la línea de costa, con tasas de erosión de hasta 70 m año-1; (2 dulcificación de los estuarios del lóbulo norte del delta, cambio hidrológico que ha ocasionando la migración de la zona alta estuarina (salinidad <1 15 km aguas abajo; y (3 alteraciones en la cobertura vegetal del Parque Nacional Natural Sanquianga, con incrementos en la vegetación de agua dulce de hasta 42%, y disminución en la cobertura de manglar de hasta 31% en un período de 15 años. Las condiciones actuales del delta del Patía son ejemplo de la importancia de las actividades humanas como agentes de cambio dentro de la evolución de los sistemas deltaicos, y revelan la necesidad de profundizar el estudio de este delta para establecer estrategias adecuadas de manejo y conservación.

  9. Alternativas tecnológicas aplicables al desarrollo y conservación de productos cárnicos cocidos (patés) durante el almacenamiento refrigerado

    OpenAIRE

    Terrasa, Ana María

    2012-01-01

    Teniendo en cuenta la relación existente entre nutrición y salud así como la demanda creciente de los consumidores de productos más saludables, en este trabajo de Tesis se han diseñado productos a base de hígado de pollo (patés o pastas de hígado) en los cuales se realizaron modificaciones de la fase grasa tanto cualitativas como cuantitativas. En ese sentido, en productos procesados elaborados con carne o vísceras, una de las estrategias utilizadas para la obtención de productos más saludabl...

  10. Técnicas moleculares para la detección e identificación de patógenos en alimentos: ventajas y limitaciones

    Directory of Open Access Journals (Sweden)

    Carolina Palomino-Camargo

    2014-09-01

    Full Text Available Las enfermedades transmitidas por alimentos, ocasionadas por microorganismos patógenos, constituyen un grave problema de salud pública a nivel mundial. Los métodos microbiológicos utilizados comúnmente en la detección de estos patógenos, de origen alimentario, son laboriosos y consume mucho tiempo. Esta situación, aunada a la demanda por resultados inmediatos y a los avances tecnológicos, ha conducido al desarrollo de una amplia gama de métodos rápidos en las últimas décadas. En base a esto, la presente revisión describe las ventajas y limitaciones de los principales métodos moleculares utilizados en la detección e identificación de microorganismos patógenos transmitidos por alimentos. Para ello, se consideró la actualidad de la información consultada, el análisis objetivo de la temática y su alcance. La literatura reciente reporta un número significativo de técnicas moleculares, alternativas, sensibles y selectivas para la detección, enumeración e identificación de microorganismos patógenos en alimentos, siendo la reacción en cadena de la polimerasa (PCR la plataforma más popular, mientras que la secuenciación de alto rendimiento se perfila como una técnica de gran aplicabilidad a futuro. Sin embargo, aun con todas las ventajas que ofrecen estas novedosas metodologías, no se deben pasar por alto sus limitaciones. Así, por ejemplo, los métodos moleculares no constituyen protocolos estandarizados, lo que dificulta su utilización en algunos casos. Por esta razón se debe trabajar arduamente para superar tales limitaciones y mejorar la aplicación de estas técnicas en matrices tan complejas como los sistemas alimenticios.

  11. Sociālo tīklu un platformas "Facebook" ietekme uz patērētāja pirkuma lēmuma pieņemšanas procesu.

    OpenAIRE

    Ķiksis, Kristiāns

    2017-01-01

    Bakalaura darba tēma ir “Sociālo tīklu un platformas “Facebook” ietekme uz patērētāja pirkuma lēmuma pieņemšanas procesu”. Veiktā darba mērķis ir izskaidrot, kāpēc, kad un kā sociālie mediji ir ietekmējuši patērētāju lēmumu pieņemšanas procesu. Teorētiskā daļa sastāv no 4 sadaļām- patērētāju uzvedība, sociālie mediji, sociālo mediju ietekme uz patērētājiem, kā arī platformas “Facebook” iespējas. Darbs ietver 4 nodaļas. Bakalaura darba teorētiskajā daļā apkopoti materiāli par patērētāju uzvedī...

  12. Reklāmas ietekme uz patērētāju izvēles veikšanā

    OpenAIRE

    Asejevs, Aleksandrs

    2012-01-01

    Bakalaura darba tēma izvēlēta „Reklāmas ietekme uz patērētāju izvēles veikšanā”. Pastiprinoties konkurencei valstu iekšzemes tirgū, uzņēmumi savas preces un pakalpojumus virza globālajā tirgū. Starptautiskajā mārketingā reklāma tiek izmantota kā viens no mārketinga komunikācijas līdzekļiem, ar kura palīdzību uzņēmumi patērētajiem virzītu savas preces un pakalpojumus. Darba mērķis: balstoties uz veiktās aptaujas rezultātiem, izstrādāt priekšlikumus reklāmas pilnveidošanai Latvijā. Lai...

  13. Quality-by-Design (QbD): An integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and process design space development.

    Science.gov (United States)

    Wu, Huiquan; White, Maury; Khan, Mansoor A

    2011-02-28

    The aim of this work was to develop an integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and design space development. A dynamic co-precipitation process by gradually introducing water to the ternary system of naproxen-Eudragit L100-alcohol was monitored at real-time in situ via Lasentec FBRM and PVM. 3D map of count-time-chord length revealed three distinguishable process stages: incubation, transition, and steady-state. The effects of high risk process variables (slurry temperature, stirring rate, and water addition rate) on both derived co-precipitation process rates and final chord-length-distribution were evaluated systematically using a 3(3) full factorial design. Critical process variables were identified via ANOVA for both transition and steady state. General linear models (GLM) were then used for parameter estimation for each critical variable. Clear trends about effects of each critical variable during transition and steady state were found by GLM and were interpreted using fundamental process principles and Nyvlt's transfer model. Neural network models were able to link process variables with response variables at transition and steady state with R(2) of 0.88-0.98. PVM images evidenced nucleation and crystal growth. Contour plots illustrated design space via critical process variables' ranges. It demonstrated the utility of integrated PAT approach for QbD development. Published by Elsevier B.V.

  14. Implementation of an advanced hybrid MPC-PID control system using PAT tools into a direct compaction continuous pharmaceutical tablet manufacturing pilot plant.

    Science.gov (United States)

    Singh, Ravendra; Sahay, Abhishek; Karry, Krizia M; Muzzio, Fernando; Ierapetritou, Marianthi; Ramachandran, Rohit

    2014-10-01

    It is desirable for a pharmaceutical final dosage form to be manufactured through a quality by design (QbD)-based approach rather than a quality by testing (QbT) approach. An automatic feedback control system coupled with PAT tools that is part of the QbD paradigm shift, has the potential to ensure that the pre-defined end product quality attributes are met in a time and cost efficient manner. In this work, an advanced hybrid MPC-PID control architecture coupled with real time inline/online monitoring tools and principal components analysis (PCA) based additional supervisory control layer has been proposed for a continuous direct compaction tablet manufacturing process. The advantages of both MPC and PID have been utilized in a hybrid scheme. The control hardware and software integration and implementation of the control system has been demonstrated using feeders and blending unit operation of a continuous tablet manufacturing pilot plant and an NIR based PAT tool. The advanced hybrid MPC-PID control scheme leads to enhanced control loop performance of the critical quality attributes in comparison to a regulatory (e.g. PID) control scheme indicating its potential to improve pharmaceutical product quality. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Parasitoidism Rate and Life Table Parameters of Aphytis diaspidis (Howard (Hymenoptera: Aphelinidae and Hemiberlesia lataniae (Signoret (Hemiptera: Diaspididae Tasa de Parasitoidismo y Parámetros de Tabla de Vida de Aphytis diaspidis (Howard (Hymenoptera: Aphelinidae y Hemiberlesia lataniae (Signoret (Hemiptera: Diaspididae

    Directory of Open Access Journals (Sweden)

    Dennis Navea O

    2012-09-01

    Full Text Available Latania scale, Hemiberlesia lataniae (Signoret, has become a major pest of avocado (Persea americana Mill. in Chile and has reached high populations in the fruit because of limited natural control. The objective of this study was to identify the biological parameters of the parasitoid Aphytis diaspidis (Howard as a control agent of latania scale. Postembryonic development, parasitoidism rate, and life table parameters of the parasitoid and scale were determined under laboratory conditions. Aphytis diaspidis postembryonic development and parasitoidism rate varied significantly when evaluated on distinct latania scale stages with the highest survival (56% occurring at the third scale stage, it also had the shortest development time between egg and adult (19.14 d and the highest parasitoidism rate (66%. The intrinsic growth rate (r m was higher for A. diaspidis (r m = 0.099 than latania scale (r m = 0.068. These laboratory results demonstrated that A. diaspidis is an effective parasitoid for decreasing H. lataniae populations, especially in the third stage.La escama latania, Hemiberlesia lataniae (Signoret, se ha transformado en Chile en una plaga de importancia primaria en palto (Persea americana Mill., donde alcanza altas poblaciones en la fruta debido al escaso control natural existente. El objetivo del presente estudio fue conocer parámetros biológicos del parasitoide Aphytis diaspidis (Howard, como agente de control de la escama latania. Es asi como se determinó en laboratorio el desarrollo postembrionario, tasa de parasitoidismo, y parámetros de tabla de vida del parasitoide y la escama. El desarrollo postembrionario y la tasa de parasitoidismo de A. diaspidis varió significativamente al ser evaluado sobre distintos estadios de la escama latania, alcanzando el mayor porcentaje de supervivencia (56% sobre el tercer estadio de la escama, asi como el menor tiempo de desarrollo entre huevo y adulto (19,14 d y la máxima tasa de

  16. Recent results on howard's algorithm

    DEFF Research Database (Denmark)

    Miltersen, P.B.

    2012-01-01

    is generally recognized as fast in practice, until recently, its worst case time complexity was poorly understood. However, a surge of results since 2009 has led us to a much more satisfactory understanding of the worst case time complexity of the algorithm in the various settings in which it applies...

  17. FLOODPLAIN MAPPING, HOWARD COUNTY, TEXAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  18. Eliminación de patógenos en biosólidos por estabilización alcalina Eliminating pathogens in biosolids by alkaline stabilization

    Directory of Open Access Journals (Sweden)

    Patricia Torres Lozada

    2009-07-01

    Full Text Available La Planta de Tratamiento de Aguas Residuales de Cañaveralejo -PTAR-C de Cali- Colombia, produce alrededor de 100 t/día de biosólidos que, aunque no tienen restricción por metales pesados, son clase B por el nivel de microorganismos patógenos y parásitos. En un diseño completamente al azar, conformado por seis tratamientos con su respectivo duplicado, se evaluó la estabilización alcalina con dosis del 9% peso a peso de cal viva e hidratada, aplicada a pilas de 0.5 t de biosólidos húmedos (66.5% y secos a temperatura ambiente (25 - 31°C durante 72 h (humedad 50.1%. Con la estabilización alcalina el pH aumentó a valores superiores a 12 unidades durante el tiempo suficiente para garantizar la reducción de patógenos y parásitos, alcanzando un material clase A; sin embargo, el biosólido seco facilitó la formación de grumos que dificultaron las labores de homogenización del sustrato con los alcalinizantes, factor indeseable para la eficiente reducción de patógenos.The Cañaveralejo wastewater treatment plant (PTAR-C based in Cali-Colombia, produces almost 100 t-day-1 of biosolids. Although do not have heavy metals restrictions, it is class B for high contents of pathogens microorganisms and parasites. The alkali stabilization was done with a 9% of dose (w/w of quicklime and hydrated lime applied to different 0.5 ton piles of wet biosolids (66.5% humidity and dry biosolids an environmental temperature (25-31°C for 72 hours (50.1% humidity. The experiment had a completely randomized design and it was composed by 6 treatments with their respective duplicated. With the alkali stabilization, the pH increments above 12 units during enough time to assure pathogens and parasites reduction in order to achieve a class A material level. On the other hand, the dry biosolids facilitate the conditions for lumps formation that reduce the homogenization of the substrate with the alkali material, which it is and undesirable factor for pathogen

  19. Perfiles de resistencia a antibióticos y metales pesados en Pseudomonas aeruginosa potencialmente patógenas aisladas de agua de uso agrícola

    Directory of Open Access Journals (Sweden)

    Oscar G. Gutiérrez Cárdenas

    2017-01-01

    Full Text Available El 70% de l agua a nivel mundial se destina principalmente para las actividades agrícolas. Sin embargo, debido al crecimiento descontrolado de los asentamientos urbanos se ha acentuado la escasez y contaminación de los cuerpos de agua superficiales, de tal forma que cada vez este líquido de buena calidad es más escaso para la agricultura. Uno de los pri n cipa les contaminantes son las bacterias potencialmente patógenas resistentes a los antibiót i cos. Pseudomonas aeruginosa es una bacteria que se encuentra normalmente en el agua y suelo, es patógeno de animales y plantas. Esta bacteria se ha considerado un fenóm eno de resistencia debido a la diversidad de mecanismos que posee, por lo cual representa un rie s go potencial para la p o blación. Método : Se colectaron muestras de agua de uso agrícola, a partir de las cuales se aislaron e identificaron a nivel bioquímico y molecular P. aeruginosa . En estas bacterias se determinó la distribución de 6 genes de virulencia por PCR. Mediante ensayos de difusión en disco y m i crodilución se analizó la resistencia a 20 antibióticos. Además mediante ensayos de microd i lución se dete rminó la resistencia a metales pesados. Resultados : Se identificaron a nivel bioquímico y molecular 46 aislados de P. aeruginosa, éstas son potencialmente patógenas ya que en ellas se detectó la presencia de los genes de virule n cia algD y toxA (100%, las B (97.8%, plcH (95.6%, plcN (91.3% y exoS (89.1%. Dichas bacterias presentaron altos índices de resistencia a ampicilina, ceftriaxona, cloranfen i col, cefalotina, cefotaxima, nitrofurantoína, kanamicina , estreptomicina y tetraciclina. De igual forma fue ron muy susceptibles a ceftazidima, gentamicina, imipenem, ticarcilina, a z treonam, levofloxacina, netilmicina y carbenicilina. Todas las bacterias fueron multirresiste n tes ya que toleraron entre 8 y 11 antibióticos. De acuerdo a los patrones de resistencia obse r vados, las bacterias se

  20. Escherichia coli O157:H7- patógeno alimentar emergente / Escherichia coli O157:H7 - emerging food pathogen

    Directory of Open Access Journals (Sweden)

    Cheila Minéia Daniel de Paula

    2014-11-01

    Full Text Available Segundo a Organização Mundial da Saúde, cerca de 2,2 milhões de pessoas morrem anualmente em função de doenças hídricas ou alimentares, a maioria dos quais são crianças. Estas doenças são causadas por patógenos já conhecidos, emergentes ou reemergentes, principalmente bactérias. A globalização tem contribuído na disseminação de patógenos de origem alimentar, aumentando o desafio relacionado à identificação da origem desses agentes e à elaboração de regulamentação e fiscalização adequadas. O cenário das Doenças Transmitidas por Alimentos (DTA muda constantemente e a prevalência de determinada doença varia de época para época, assim como os agentes etiológicos destas. Dentre os principais patógenos emergentes em nível mundial, E. coli O157:H7 tem ganhado grande destaque nos últimos 20 anos, devido à severidade de seus surtos. Até pouco tempo, o Brasil era considerado livre desse patógeno, porém a bibliografia científica e registros epidemiológicos demonstram o contrário. Em vista disso, o presente artigo objetiva realizar uma revisão integrativa da literatura, enfocando as características, os métodos de isolamento e detecção e os dados epidemiológicos da E. coli O157:H7 no Brasil e no mundo. =============================================== According to the World Health Organization, about 2.2 million people, most of whom are children, die each year due to water and foodborne illnesses. These illnesses are caused by known, emerging, or reemerging pathogens, mainly bacteria. Globalization has contributed to the spread of foodborne pathogens, increasing the challenge of identifying the origin of these agents and of developing appropriate regulation and monitoring. The scenario of Foodborne Illnesses (FI constantly changes and the prevalence of a particular illnesses as well as its etiological agents, vary from season to season. Among the major emerging pathogens at a global level, E. coli O157:H7

  1. Green synthesis and antimicrobial activity of silver nanoparticles using wild medicinal mushroom Ganoderma applanatum (Pers.) Pat. from Similipal Biosphere Reserve, Odisha, India.

    Science.gov (United States)

    Mohanta, Yugal Kishore; Singdevsachan, Sameer Kumar; Parida, Umesh Kumar; Panda, Sujogya Kumar; Mohanta, Tapan Kumar; Bae, Hanhong

    2016-08-01

    In the present study, green synthesis and cost effective approach of silver nanoparticles using wild medicinal mushroom Ganoderma applanatum (Pers.) Pat. from Similipal Biosphere Reserve, Odisha, India is reported. The biosynthesised AgNPs were characterised using UV-visible spectroscopy, particle analyser and scanning electron microscopy studies. It was found by dynamic light scattering analysis, that the average size and charges of the AgNPs were 133.0 ± 0.361 nm and -6.01 ± 5.30 mV, respectively. Moreover, the Fourier transform infrared study was also conducted to identify the biomolecules or functional groups responsible for the reduction of Ag and stabilisation of the AgNPs. The potential biomedical application with reference to antimicrobial activity of the synthesised AgNPs was investigated against some pathogenic microorganisms viz. Escherichia coli, Bacillus subtilis, Staphylococcus epidermidis, Vibrio cholerae, Staphylococcus aureus and Shigella flexneri.

  2. 125I-BH-8-MeO-N-PAT, a new ligand for studying 5-HT1A receptors in the central nervous system

    International Nuclear Information System (INIS)

    Ponchant, M.; Beaucourt, J.P.; Vanhove, A.

    1988-01-01

    Specific radioactive ligands are needed for studying the pharmacological properties and the regional distribution of the different classes of 5-HT 1 receptors within the central nervous system. We describe here the synthesis and some characteristics of the first iodinated specific ligand of 5-HT 1A receptors. Like its parent compound, the agonist 8-hydroxy-2-(di-n-propylamino)tetralin or 8-OH-DPAT, [ 125 I]-BH-8-MeO-N-PAT, exhibits a high affinity and excellent selectivity for 5-HT 1A sites. Its high specific radioactivity makes this ligand a useful tool for studying 5-HT 1A receptors in membranes and sections of the rat brain [fr

  3. Headspace solid-phase microextraction (HS-SPME) combined with GC-MS as a process analytical technology (PAT) tool for monitoring the cultivation of C. tetani.

    Science.gov (United States)

    Ghader, Masoud; Shokoufi, Nader; Es-Haghi, Ali; Kargosha, Kazem

    2018-04-15

    Vaccine production is a biological process in which variation in time and output is inevitable. Thus, the application of Process Analytical Technologies (PAT) will be important in this regard. Headspace solid - phase microextraction (HS-SPME) coupled with GC-MS can be used as a PAT for process monitoring. This method is suitable to chemical profiling of volatile organic compounds (VOCs) emitted from microorganisms. Tetanus is a lethal disease caused by Clostridium tetani (C. tetani) bacterium and vaccination is an ultimate way to prevent this disease. In this paper, SPME fiber was used for the investigation of VOCs emerging from C. tetani during cultivation. Different types of VOCs such as sulfur-containing compounds were identified and some of them were selected as biomarkers for bioreactor monitoring during vaccine production. In the second step, the portable dynamic air sampling (PDAS) device was used as an interface for sampling VOCs by SPME fibers. The sampling procedure was optimized by face-centered central composite design (FC-CCD). The optimized sampling time and inlet gas flow rates were 10 min and 2 m L s -1 , respectively. PDAS was mounted in exhausted gas line of bioreactor and 42 samples of VOCs were prepared by SPME fibers in 7 days during incubation. Simultaneously, pH and optical density (OD) were evaluated to cultivation process which showed good correlations with the identified VOCs (>80%). This method could be used for VOCs sampling from off-gas of a bioreactor to monitoring of the cultivation process. Copyright © 2018. Published by Elsevier B.V.

  4. An integrated process analytical technology (PAT) approach to monitoring the effect of supercooling on lyophilization product and process parameters of model monoclonal antibody formulations.

    Science.gov (United States)

    Awotwe Otoo, David; Agarabi, Cyrus; Khan, Mansoor A

    2014-07-01

    The aim of the present study was to apply an integrated process analytical technology (PAT) approach to control and monitor the effect of the degree of supercooling on critical process and product parameters of a lyophilization cycle. Two concentrations of a mAb formulation were used as models for lyophilization. ControLyo™ technology was applied to control the onset of ice nucleation, whereas tunable diode laser absorption spectroscopy (TDLAS) was utilized as a noninvasive tool for the inline monitoring of the water vapor concentration and vapor flow velocity in the spool during primary drying. The instantaneous measurements were then used to determine the effect of the degree of supercooling on critical process and product parameters. Controlled nucleation resulted in uniform nucleation at lower degrees of supercooling for both formulations, higher sublimation rates, lower mass transfer resistance, lower product temperatures at the sublimation interface, and shorter primary drying times compared with the conventional shelf-ramped freezing. Controlled nucleation also resulted in lyophilized cakes with more elegant and porous structure with no visible collapse or shrinkage, lower specific surface area, and shorter reconstitution times compared with the uncontrolled nucleation. Uncontrolled nucleation however resulted in lyophilized cakes with relatively lower residual moisture contents compared with controlled nucleation. TDLAS proved to be an efficient tool to determine the endpoint of primary drying. There was good agreement between data obtained from TDLAS-based measurements and SMART™ technology. ControLyo™ technology and TDLAS showed great potential as PAT tools to achieve enhanced process monitoring and control during lyophilization cycles. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  5. Avaliação da estabilidade e da qualidade do patê de presunto, adicionado de globina bovina e de caseinato de sódio, como agente emulsionante Stability and quality of ham paté added of bovine globin and sodium caseinate as emulsifiers

    Directory of Open Access Journals (Sweden)

    Janaína Guernica Silva

    2003-04-01

    Full Text Available Este trabalho foi conduzido para avaliar o efeito da incorporação das globinas bovina extraída pelo método da acetona acidificada (GT e pelo da carboximetilcelulose (GCMC e do caseinato de sódio (CA sobre a composição química e as qualidades microbiológica e sensorial do patê de presunto. Foi, ainda, avaliada a estabilidade do produto durante os 45 dias de estocagem sob refrigeração, por meio das determinações de pH e do grau de oxidação lipídica. De acordo com os resultados obtidos, pôde-se verificar que a adição dessas proteínas elevou o teor protéico das amostras analisadas. Além disso, observou-se que apenas a GT provocou uma queda do pH e uma elevação de substâncias reativas ao ácido 2-tiobarbitúrico (thiobarbiuric acid reactive substances - TBARS. Com relação à qualidade microbiológica dos produtos, não foram observadas alterações após a incorporação das proteínas e, pela análise sensorial, foram identificadas diferenças significativas entre as duas formulações de patê avaliadas (PCA e PGCMC.This study evaluated the effect of the use of bovine globin extracted by acidified acetone method (GT, bovine globin extracted by carboxymethyl cellulose method (GCMC and sodium caseinate (CA on the chemical composition and on microbiological and sensorial qualities of the ham paté. Also, the stability of this meat product was studied during the storage for 45 days under refrigeration, on the pH and on the lipid oxidation measurements. An increase of the protein contents was observed in all samples. Moreover, only the incorporation of GT produced a significant decrease of pH and an increasing of thiobarbiuric acid reactive substances (TBARS values during storage. No microbial effects were observed while some significant differences were observed between PCA and PGCMC added patés.

  6. In Search of a House with a View: The conception of dwelling in E.M. Forster’s Howards End and Iris Murdoch’s The Sea, The Sea

    Directory of Open Access Journals (Sweden)

    Tereza Topolovská

    2016-07-01

    Full Text Available This article elaborates on the thematic connections between E.M. Forster’s 1910 Howards End and Iris Murdoch’s 1978 The Sea, The Sea, namely their poetic conception of dwelling. Besides echoing the major social and cultural concerns of their individual periods, these novels vigorously examine timeless issues as the nature of dwelling, the extent of the influence of a social class on the treatment of environmental issues. Both novels mirror the wide-ranging and longstanding debate that engages with diverse variables of the equation comprising technological progress, undisturbed nature and intensity of human involvement. The great variety of subject matter in both novels might easily have resulted in a melange of pompous moralising had they not featured two houses, namely Howards End and Shruff End, whose symbolism anchors the narration while adding to the thematic richness of both works. Operating both on metaphorical and literal levels, the houses in question provide a solid foundation for the analysis of the texts.

  7. Regeneration de Pat Barker (1991 : la gestion des maux/mots de la Grande Guerre par l’institution psychiatrique

    Directory of Open Access Journals (Sweden)

    Isabelle Gérardin

    2011-04-01

    Full Text Available Cet article se propose d’étudier une œuvre publiée en 1991 par la romancière anglaise Pat Barker : Regeneration. Ce roman, qui a pour toile de fond la Grande Guerre, ne dépeint ni combats ni scènes de la vie des tranchées. Barker préfère représenter toute la dimension agonistique de ce conflit mondial à travers la question de la prise en charge des traumatismes de guerre des soldats par l’institution psychiatrique. Ces traumatismes, ayant diverses manifestations psychosomatiques, témoignent d’une forte tension entre une profonde aversion de l’individu pour l’extrême violence des affrontements et un appel à se conformer à une certaine culture de guerre collective fondée sur un idéal fort de virilité martiale et patriotique. Face à ces traumatismes, ainsi que Pat Barker le met en lumière, la psychiatrie de guerre se révèle souvent fort ambiguë. En effet, l’institution psychiatrique œuvre en continuité avec l’institution militaire, désirant imposer un contrôle sur les âmes autant que sur les corps. Regeneration nous invite donc à lire combien les maux/mots de la Grande Guerre ont eu grand peine à se faire entendre.This article deals with a novel, entitled Regeneration, published in 1991 by the English female author Pat Barker. This novel, although set against the backdrop of World War One, depicts neither battles nor scenes of everyday life in the trenches. Instead, the agonistic dimension of this world conflict is tackled by Pat Barker through the prism of the way the psychiatric institution dealt with war traumas endured by soldiers, traumas of the body and of the mind. These traumas, causing a variety of psychosomatic symptoms, reveal a powerful tension between a deep individual aversion to the extreme violence of combat and an appeal to conform to some collective culture of war rooted in a strong ideal of soldierly and patriotic manliness. Wartime psychiatry, as Barker highlights, often turns out to

  8. CaMKII-MEDIATED PHOSPHORYLATION OF THE BOMBYX MORI LIPID STORAGE DROPLET PROTEIN-1 (BmLsd1), AN INSECT PAT FAMILY PROTEIN, IS ESSENTIAL FOR SILKMOTH SEX PHEROMONE BIOSYNTHESIS

    Science.gov (United States)

    The structurally-related members of the PAT family of proteins, which are so name based on similarity amongst perilipin, adipophilin/adipocyte differentiation-related protein (ADRP), and tail-interacting protein of 47 kilodaltons (TIP47), are cytoplasmic lipid droplet (LD)-associated proteins charac...

  9. Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca2+/calmodulin-dependent protein kinase II-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage droplet protein-1(BmLsd)

    Science.gov (United States)

    The structurally-related members of the PAT family of proteins, which are so name based on similarity amongst perilipin, adipophilin/adipocyte differentiation-related protein (ADRP), and tail-interacting protein of 47 kilodaltons (TIP47), are cytoplasmic lipid droplet (LD)-associated proteins charac...

  10. Changes of seasonally dry forest in the Colombian Patía Valley during the early and middle Holocene and the development of a dry climatic record for the northernmost Andes

    NARCIS (Netherlands)

    González-Carranza, Z.; Berrío, J.C.; Hooghiemstra, H.; Duivenvoorden, J.F.; Behling, H.

    2008-01-01

    A 450 cm long sediment core was collected from a swamp in the dry forest ecosystem of the Patía Valley in Colombia (02°02′ N, 77° W at 750 m elevation). This core (Potrerillo-2) was analysed using pollen, lithostratigraphy and radiocarbon dates and was correlated with an already existing dataset

  11. Simultaneous enrichment of cysteine-containing peptides and phosphopeptides using a cysteine-specific phosphonate adaptable tag (CysPAT) in combination with titanium dioxide (TiO2) chromatography

    DEFF Research Database (Denmark)

    Huang, Honggang; Pedersen, Martin Haar; Ibañez-Vea, Maria

    2016-01-01

    to selectively label cysteine-containing peptides (Cys peptides) followed by their enrichment with titanium dioxide (TiO2) and subsequent mass spectrometric analysis. The CysPAT strategy was developed using a synthetic peptide, a standard protein and subsequently the strategy was applied to protein lysates from...

  12. Ocorrência de patógenos em cultivos de melancia e abóbora no sertão da Paraíba

    Directory of Open Access Journals (Sweden)

    M. G. F. O. Soares

    2016-01-01

    Full Text Available Por constituírem uma importante fonte de alimento, plantações de melancia e abóbora são comumente cultivadas no sertão paraibano, porém pouco se sabe sobre a ocorrência de patógenos causadores de doenças, os quais limitam a sua produtividade e renda aos produtores. Visando obter informações sobre a ocorrência dos patógenos virais e fúngicos em cultivos de abóbora e melancia situados em municípios produtores no sertão da Paraíba, amostras coletadas com sintomas de mosaico e deformação foliar, típicos de doenças virais foram analisadas pela técnica sorológica “enzime linked immuno sorbentassay” (Elisa indireto para Papaya ring spot virus, type watermelon (PRSV-W, Watermelon mosaic virus (WMV, Zucchini yellow mosaic virus (ZYMV e Cucumber mosaic virus (CMV. O teste de dupla difusão em Agar foi utilizado para verificar a presença de Squash mosaic virus (SqMV. Em contrapartida, amostras coletadas com sintomas de doenças fúngicas foram analisadas pelo isolamento do patógeno e visualização de suas características morfológicas em microscópio óptico. Em abóbora, houve prevalência dos vírus ZYMV e PRSV-W em infecções simples e mistas, e maior incidência dos fungos Cladosporium spp., e Alternaria spp. Em melancia detectou-se infecção simples e mistas das espécies PRSV-W, WMV e ZYMV, e maior freqüência de Fusarium spp. e Alternaria spp.. Não foram detectados os vírus CMV e SqMV. Os resultados obtidos revelam a ocorrência de vários patógenos fúngicos e viróticos em cultivos de abóbora e melancia situados no sertão da Paraíba e ressaltam a importância da utilização de estratégias de manejo que reduzem os danos ocasionados por esses patógenos.Occurrence of pathogens in watermelon and pumpkin crops in the State of ParaibaAbstract: By constitute an important food source, watermelon and pumpkin plantations are commonly grown on Paraíba backlands, but little is known about the occurrence of disease

  13. La Riḥla de Omar Patún: el viaje de peregrinación a la Meca de un musulmán de Ávila a finales del siglo XV (1491–1495 = Omar Patún’s Riḥla : The Journey of the Pilgrimage to Mecca of a Muslim from Ávila at the End of the Fifteenth Century (1491–1495

    Directory of Open Access Journals (Sweden)

    Xavier Casassas Canals

    2015-06-01

    Full Text Available En este artículo presentamos la Riḥla de Omar Patún, un relato de viaje y de peregrinación desde Ávila a la Meca realizado por un musulmán castellano a finales del siglo XV. Se trata de un manuscrito inédito hallado en Calanda y conservado en la Biblioteca de Las Cortes de Aragón. Publicamos una selección de textos mostrando las principales etapas del viaje, las circunstancias del mismo y la descripción de algunas de las principales ciudades que visitó Omar Patún. A partir de algunas noticias y referencias, directas e indirectas, a acontecimientos históricos determinamos la fecha exacta del viaje de Omar Patún (1491–1495 y establecemos la cronología de las diferentes etapas y escalas. Ponemos así en conocimiento un documento fundamental para todos aquellos interesados en el estudio de la comunidad musulmana de época mudéjar, que aporta datos novedosos que habrá de tener en cuenta a partir de ahora cuando se hable de la religiosidad de los mudéjares castellanos y de los desplazamientos de éstos a Oriente y en especial a la Meca.This article presents Omar Patún’s Riḥla, an itinerary of the pilgrimage from Ávila to Mecca undertaken by a Castilian Muslim at the end of the fifteenth century. This is an unpublished manuscript found in Calanda and preserved in the Library of the Cortes de Aragón. The selection of texts offered here will identify the most important stages of the journey, its circumstances and the description of some of the cities visited by Patún. Certain news and references in the text to historical events, both direct and indirect, help to date Omar Patún’s journey between 1491–1495, and to establish the chronology of the different stages of the trip and stops on the way. We bring to light an outstanding source for those interested in the Islamic community in Mudejar times as it provides new insights into the religiosity of Castilian Mudejars and their journeys to the Middle

  14. Tout cela est bien quelque chose: Digital Preservation Today: how European Commission programmes and policy have brought us here: Festschrift for Patricia (Pat Manson

    Directory of Open Access Journals (Sweden)

    Janet Delve

    2017-05-01

    Full Text Available Patricia (Pat Manson worked with the European Commission's (EC’s research programmes from the early 1990s, initially as project officer (December 1991-March 2003 and then as Head of Unit (April 2003-2011 for Cultural Heritage and Technology Enhanced Learning which was part of the Directorate General Information Society and Media. The unit focused primarily on research in digital libraries, digital preservation, and in the use of ICTs for improving learning, but was also involved in the development of the i2010 digital libraries policies and actions. Prior to joining the Commission, she worked in the UK providing a national advisory and market watch service to libraries on the use of new technologies. She is now Head of the Inclusion, Skills & Youth Unit of the EC’s Directorate General for Communication Networks, Content and Technology (DG CONNECT, where the unit’s goal is to ensure that citizens, especially youth and those at risk of exclusion, are best able to benefit from the Internet and have the necessary skills so to do. This article sets out Pat’s leadership of EC-funded Digital Preservation, and examines her legacy in terms of lasting best practices, contributions to standardisation activities etc.

  15. Patèr kaì poietés : numenio y la interpretación de Timeo 28 c 3

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    Gabriela F. Müeller

    2009-09-01

    Full Text Available En el célebre pasaje Timeo 28 c 3-5 leemos: “Descubrir al hacedor y padre de este universo es difícil, pero, una vez descubierto, comunicárselo a todos es imposible.” En el presente trabajo me propongo indagar la peculiar interpretación que realiza Numenio de estas líneas y el papel que dicha exégesis cumple en la conformación de su sistema metafísico. En este sentido, intentaré establecer los motivos que llevan a Numenio a invertir los términos del Timeo y a distinguir un primer dios (patér de un segundo dios (poietés, identificando a este último con el demiurgo. Para esto analizaré algunos fragmentos conservados de su obra Perì tagathoû en los que caracteriza al primer y al segundo dios, procurando poner de manifiesto en qué otros textos platónicos podría basarse esta doctrina y en qué medida ella representa una innovación en la historia de la interpretación de la filosofía de Platón realizada por los platónicos.

  16. Combining microwave resonance technology to multivariate data analysis as a novel PAT tool to improve process understanding in fluid bed granulation.

    Science.gov (United States)

    Lourenço, Vera; Herdling, Thorsten; Reich, Gabriele; Menezes, José C; Lochmann, Dirk

    2011-08-01

    A set of 192 fluid bed granulation batches at industrial scale were in-line monitored using microwave resonance technology (MRT) to determine moisture, temperature and density of the granules. Multivariate data analysis techniques such as multiway partial least squares (PLS), multiway principal component analysis (PCA) and multivariate batch control charts were applied onto collected batch data sets. The combination of all these techniques, along with off-line particle size measurements, led to significantly increased process understanding. A seasonality effect could be put into evidence that impacted further processing through its influence on the final granule size. Moreover, it was demonstrated by means of a PLS that a relation between the particle size and the MRT measurements can be quantitatively defined, highlighting a potential ability of the MRT sensor to predict information about the final granule size. This study has contributed to improve a fluid bed granulation process, and the process knowledge obtained shows that the product quality can be built in process design, following Quality by Design (QbD) and Process Analytical Technology (PAT) principles. Copyright © 2011. Published by Elsevier B.V.

  17. Quality by design (QbD), Process Analytical Technology (PAT), and design of experiment applied to the development of multifunctional sunscreens.

    Science.gov (United States)

    Peres, Daniela D'Almeida; Ariede, Maira Bueno; Candido, Thalita Marcilio; de Almeida, Tania Santos; Lourenço, Felipe Rebello; Consiglieri, Vladi Olga; Kaneko, Telma Mary; Velasco, Maria Valéria Robles; Baby, André Rolim

    2017-02-01

    Multifunctional formulations are of great importance to ensure better skin protection from harm caused by ultraviolet radiation (UV). Despite the advantages of Quality by Design and Process Analytical Technology approaches to the development and optimization of new products, we found in the literature only a few studies concerning their applications in cosmetic product industry. Thus, in this research work, we applied the QbD and PAT approaches to the development of multifunctional sunscreens containing bemotrizinol, ethylhexyl triazone, and ferulic acid. In addition, UV transmittance method was applied to assess qualitative and quantitative critical quality attributes of sunscreens using chemometrics analyses. Linear discriminant analysis allowed classifying unknown formulations, which is useful for investigation of counterfeit and adulteration. Simultaneous quantification of ethylhexyl triazone, bemotrizinol, and ferulic acid presented at the formulations was performed using PLS regression. This design allowed us to verify the compounds in isolation and in combination and to prove that the antioxidant action of ferulic acid as well as the sunscreen actions, since the presence of this component increased 90% of antioxidant activity in vitro.

  18. Patógenos periodontales y sus relaciones con enfermedades sistémicas Periodontal pathogens and their relationships with systemic diseases

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    Maritza Peña Sisto

    2012-07-01

    Full Text Available Las enfermedades periodontales son infecciones caracterizadas por la presencia de más de 200 especies bacterianas que, por infestación metastásica, pueden llegar a diferentes órganos anatómicos y ocasionar cambios patológicos. En este artículo se describen los datos más importantes sobre el descubrimiento de los diversos patógenos periodontales en diferentes sistemas del organismo humano, sus aspectos epidemiológicos, mecanismos de acción, así como su relación con la patogenia de las diferentes enfermedades. También se hace mención especial de la presencia de estos gérmenes como iniciadores y perpetuadores de procesos sépticos en los sistemas cardiovascular, respiratorio, gastrointestinal, renal, nervioso, oftálmico y en el embarazo.Periodontal diseases are infections characterized by the presence of more than 200 bacterial species that, through metastasic infection, can reach different anatomical organs and can cause pathological changes. In this work the most important data are described on the discovery of the diverse periodontal pathogens in different systems of the human organism, their epidemiological aspects, action mechanisms, as well as their relationship with the pathogenesis of different diseases. Special mention is also made on the presence of these germs as begginners and perpetuators of septic events in the cardiovascular, respiratory, gastrointestinal, renal, nervous, ophthalmic systems and in pregnancy.

  19. Corynebacterium striatum infecting a malignant cutaneous lesion: the emergence of an opportunistic pathogen Corynebacterium striatum infectando lesão cutânea maligna: a emergência de um patógeno oportunista

    Directory of Open Access Journals (Sweden)

    Silvana Vargas Superti

    2009-04-01

    Full Text Available We described a case of a 27-year old male patient with skin and soft tissue infection of a neoplastic lesion caused by Corynebacterium striatum, an organism which has been rarely described as a human pathogen. Identification was confirmed by DNA sequencing. Successful treatment with penicillin was achieved. The role of the C. striatum as an emerging opportunistic pathogen is discussed.Descrevemos infecção de lesão neoplásica em paciente masculino de 27 anos, envolvendo pele e partes moles, causada por Corynebacterium striatum, um microrganismo raramente descrito como patógeno humano. A identificação foi confirmada por seqüenciamento de DNA. O paciente foi tratado com penicilina, com sucesso. O papel do C. striatum como patógeno oportunista é discutido.

  20. “Church trailblazer Rev Pat Storey on Weight Watchers, caffeine and how she named her dog after former New York Mayor”: News representations of the first female Anglican Bishop in the UK and Ireland

    OpenAIRE

    Power, Kate

    2017-01-01

    The first female bishop in the Anglican Church of the UK and Ireland was consecrated on November 30, 2013. For many within the Anglican Communion, the appointment of Reverend Pat Storey as Bishop of Meath and Kildare represented the opening of a longawaited new chapter in the history of Anglicanism. It is also potentially an occasion of considerable interest for both Irish historians and discourse analysts. For, although questions of gender and language have been widely considered in recent y...

  1. Vīrieša tēls patērētāju priekšstatos: žurnāla "Klubs" 2014. gada reklāmu analīze

    OpenAIRE

    Blumberga, Lelde

    2015-01-01

    Bakalaura darba ”Vīriešu tēls patērētāju priekšstatos: žurnāla „Klubs” 2014. gada reklāmu analīze” mērķis ir noskaidrot, kāds vīrieša tēls tiek veidots vīriešu žurnālu reklāmas un tā patērētāja priekšstatos. Darba pētnieciskā problēma paredz, ka vīriešu tēls vīriešu žurnālos tiek pasniegts kā spilgts, veiksmīgs un ietekmīgs, kas var atstāt iespaidu uz patērētāja apziņu. Darbs sastāv no trīs daļām – teorētiskās, metodoloģiskās un empīriskās. Darba teorētiskajā daļā tiks apskatīta teorij...

  2. Zīmola vērtība no patērētāju perspektīvas sporta apģerbu un apavu tirgū.

    OpenAIRE

    Kadakovska, Agnese

    2017-01-01

    Bakalaura darba tēma ir “Zīmola vērtība no patērētāju perspektīvas sporta apģērbu un apavu tirgū”. Bakalaura darba mērķis ir pamatojoties uz izpētīto teorētisko informāciju par zīmola vērtības no patērētāju perspektīvas veidošanu, identificēt patērētāju skatījumā vērtīgākos sporta apģērbu un apavu tirgus zīmolus Latvijā un izstrādāt priekšlikumus to vērtības palielināšanai. Bakalaura darbs sastāv no ievada, 3 nodaļām, secinājumiem un priekšlikumiem, izmantotās literatūras saraksta un pielikum...

  3. Zīmola nozīme patērētāju lēmuma pieņemšanā mēbeļu mazumtirdzniecībā.

    OpenAIRE

    Pētersons, Miks

    2013-01-01

    Maģistra darba temats ir „Zīmola nozīme patērētāju lēmuma pieņemšanā mēbeļu mazumtirdzniecībā”. Darba mērķis ir teorētiski analizēt un praktiski noskaidrot zīmola nozīmi patērētāja lēmuma pieņemšanā par mēbeļu iegādi. Temats ir aktuāls un darbā apkopotie rezultāti var būt saistoši Latvijas mēbeļu nozares dalībniekiem. 1. nodaļā autors izvērtē patērētāju uzvedību noteicošos faktorus, kā arī zīmola nozīme lēmuma pieņemšanā. 2. nodaļā analizēta mēbeļu ražošanas nozare Latvijā, veikta uzņēm...

  4. Project PAT (Pumps Working as Turbines)/IG (Induction Generators): a new concept for generation of electric power through micro scale hydroelectric power plants; Projeto BFT (Bombas Funcionado como Turbinas)/GI (Geradores de Inducao): um novo conceito para geracao de energia eletrica atraves de microcentrais hidreletricas

    Energy Technology Data Exchange (ETDEWEB)

    Viana, Augusto Nelson Carvalho [Universidade Federal de Itajuba (UNIFEI), Itajuba, MG (Brazil). Inst. de Recursos Naturais. Programa de Pos-graduacao em Engenharia da Energia; Medeiros, Daniel de Macedo; Ricardo, Mateus [Universidade Federal de Itajuba (UNIFEI), Itajuba, MG (Brazil). Inst. de Recursos Naturais], Emails: augusto@unifei.edu.br, macedo@unifei.edu.br, mathidr@yahoo.com.br

    2006-07-01

    The present work has as objective to present the main bases of 'PAT/IG Project', accomplished in Boa Esperanca Farm (Delfim Moreira - MG), by an accord between Itajuba's Federal University and Mines and Energy Ministry. In a moment that the look for sustainable development is the law in Brazil, low costs and environmental impact alternatives must be prioritized. By this way, the PAT/IG Project continuous the Viana's (1987) works, that developed all Brazilian theoretical bases for using Pumps Working as Turbine (PAT). Besides that, the application of induction motors operating as induction generators will be evaluated, as the velocity control system of the PAT/IG group will be developed. The existing Boa Esperanca Farm's micro power plant will be rebuild ed, to receive a new generating group formed for a PAT and a IG, that will be used as natural sized test workbench of Itajuba's Federal University. At the ending of the project, there will be enough subsidies to prove, in practice, the feasibility presented in laboratorial tests by PAT/IG groups as conventional turbines replacer in micro powerplants. (author)

  5. Project PAT (Pumps Working as Turbines)/IG (Induction Generators): a new concept for generation of electric power through micro scale hydroelectric power plants; Projeto BFT (Bombas Funcionado como Turbinas)/GI (Geradores de Inducao): um novo conceito para geracao de energia eletrica atraves de microcentrais hidreletricas

    Energy Technology Data Exchange (ETDEWEB)

    Viana, Augusto Nelson Carvalho [Universidade Federal de Itajuba (UNIFEI), Itajuba, MG (Brazil). Inst. de Recursos Naturais. Programa de Pos-graduacao em Engenharia da Energia; Medeiros, Daniel de Macedo; Ricardo, Mateus [Universidade Federal de Itajuba (UNIFEI), Itajuba, MG (Brazil). Inst. de Recursos Naturais], Emails: augusto@unifei.edu.br, macedo@unifei.edu.br, mathidr@yahoo.com.br

    2006-07-01

    The present work has as objective to present the main bases of 'PAT/IG Project', accomplished in Boa Esperanca Farm (Delfim Moreira - MG), by an accord between Itajuba's Federal University and Mines and Energy Ministry. In a moment that the look for sustainable development is the law in Brazil, low costs and environmental impact alternatives must be prioritized. By this way, the PAT/IG Project continuous the Viana's (1987) works, that developed all Brazilian theoretical bases for using Pumps Working as Turbine (PAT). Besides that, the application of induction motors operating as induction generators will be evaluated, as the velocity control system of the PAT/IG group will be developed. The existing Boa Esperanca Farm's micro power plant will be rebuild ed, to receive a new generating group formed for a PAT and a IG, that will be used as natural sized test workbench of Itajuba's Federal University. At the ending of the project, there will be enough subsidies to prove, in practice, the feasibility presented in laboratorial tests by PAT/IG groups as conventional turbines replacer in micro powerplants. (author)

  6. Evaluación de patógenos en clones de lulo (Solanum quitoense Lam. Pathogenity evaluation on Solanum quitoense Lam. Clones

    Directory of Open Access Journals (Sweden)

    Consuelo Montes Rojas

    2010-04-01

    Full Text Available En el noroccidente de Popayán, Colombia, se evaluó la presencia de plagas causadas por patógenos en 42 clones de lulo (Solanum quitoense Lam.. Los clones fueron plantados en bolsas plásticas, donde se desarrollaron por 3 semanas antes de ser trasplantados al campo. Se utilizó un diseño de bloques completos al azar con cuatro repeticiones, la parcela útil estuvo conformada por 6 plantas, las cuales se sembraron a ‘tresbolillo’ a 2.5 m entre surcos y 2 m entre plantas. Para determinar el efecto de las plagas en el cultivo, se calculó el porcentaje de incidencia y severidad del ataque. La incidencia se evaluó como porcentaje de plantas afectadas, y la severidad como porcentaje de tejido afectado por el patógeno. Las enfermedades más limitantes para los 42 clones fueron: gota (Phytophthora infestans que provocó una mortalidad de plantas superior a 40%; fusarium (Fusarium oxysporum que se presentó en 12 de los clones evaluados; antracnosis (Colletotrichum sp. que afectó 21 clones, los cuales se clasificaron entre tolerantes y medianamente tolerantes; y mancha clorótica (Cladosporium sp. que afectó 21 clones, clasificados como susceptibles. Los clones PL19, PL24, PL11, PL35 fueron medianamente tolerantes. Se seleccionaron por supervivencia los clones: JY E1 (52.2%, PH E 1 (45.8%, VM E2 (45.8%; por supervivencia y por tolerancia a Fusarium oxysporum los clones PL35, PL11, PL24, PL8, PL19, 120052, 120043, ORE1, AGE1. Los clones SER 7, SER 15, SER 9, SEC 31, SEC 27 presentaron alta mortalidad pero se seleccionaron por ser medianamente tolerantes a gota, tolerantes a antracnosis y medianamente resistentes a nematodos, con buen vigor y producción.Presence of plant disease caused by pathogens on 42 clones of Solanum quitoense Lam. were evaluated in the north-western region of Popayán, Colombia. The seed of the clons were planted in plastic bags during three weeks and afterwards transplanted to the field. The statistical design

  7. Bacillus anthracis: una mirada molecular a un patógeno célebre Bacillus anthracis: a molecular look at a famous pathogen

    Directory of Open Access Journals (Sweden)

    María E Pavan

    2011-12-01

    Full Text Available Bacillus anthracis es un bacilo gram positivo del grupo Bacillus cereus, que posee un genoma extremadamente monomórfco y comparte gran similitud fsiológica y de estructura genética con B. cereus y Bacillus thuringiensis. En este artículo se describen nuevos métodos moleculares para la identifcación y tipifcación de B. anthracis, basados en repeticiones en tándem de número variable o en diferencias genéticas detectadas por secuenciación, desarrollados en los últimos años. Los aspectos moleculares de los factores de virulencia tradicionales, cápsula, antígeno protector, factor letal y factor edema se describen en profundidad, junto con factores de virulencia recientemente propuestos, como los sideróforos, petrobactina y bacilibactina, la adhesina de la capa S y la lipoproteína MntA. También se detalla la organización molecular de los megaplásmidos pXO1 y pXO2, incluyendo la isla de patogenicidad de pXO1. El esqueleto genético de estos plásmidos se ha encontrado en otras especies relacionadas, probablemente debido a eventos de transferencia lateral. Finalmente, se presentan los dos receptores celulares del antígeno protector, ANTXR1/TEM8 y ANTXR2/CMG2, esenciales en la interacción del patógeno con el hospedador. Los estudios moleculares realizados en los últimos años han permitido aumentar enormemente el conocimiento de los diferentes aspectos de este microorganismo y su relación con el hospedador, pero a la vez han abierto nuevos interrogantes sobre este notorio patógeno.Bacillus anthracis, a gram-positive rod belonging to the Bacillus cereus group, has an extremely monomorphic genome, and presents high structural and physiological similarity with B. cereus and Bacillus thuringiensis. In this work, the new molecular methods for the identifcation and typing of B. anthracis developed in the last years, based on variable number tandem repeats or on genetic differences detected through sequencing, are described. The

  8. Bacillus cereus un patógeno importante en el control microbiológico de los alimentos / Bacillus cereus an important pathogen the microbiological control of food

    Directory of Open Access Journals (Sweden)

    Jennifer Sánchez

    2016-05-01

    Full Text Available Resumen Bacillus cereus es una bacteria genéticamente diversa que se encuentra comúnmente en el ambiente. Contamina los alimentos afectando la salud humana, al ingerir el microorganismo y/o sus toxinas, la emética o las enterotoxinas. En Colombia son escasos los reportes de intoxicación por B. cereus y se estima que hay un gran subregistro. Por lo anterior, se recomienda aumentar la vigilancia de este patógeno y realizar estudios sobre aspectos relevantes que permitan aplicar medidas de control para disminuir las intoxicaciones por B. cereus. El objetivo de esta revisión bibliográfica es presentar información actualizada sobre B. cereus, que incluye aspectos de su biología, taxonomía, toxinas, alimentos que contamina y metodologías para detectar, prevenir y controlar este microorganismo. La información presentada es de utilidad para el público en general, especialmente personas vinculadas al sector de alimentos, inocuidad alimentaria y control de procesos. / Abstract Bacillus cereus is a genetically diverse bacterium commonly found in the environment. It contaminates food, thus affecting human health upon ingestion of the microorganism and/or its toxins, the emetic or enterotoxins. In Colombia, reports of intoxication by B. cereus are scarce and under-registration is presumed. Because of this, it is recommended to increase surveillance of this pathogen and to develop studies on relevant aspects that allow the application of control measures to reduce intoxications by B. cereus. The aim of this review is to present current information on B. cereus, including aspects of its biology, taxonomy, toxins, food that it contaminates and methodologies for the detection, prevention and control of this microorganism. This information is useful for the general public, especially people involved with the food sector, food safety and process control.

  9. Primera incursión en la obtención de curieles libre de patógenos específicos en Cuba

    Directory of Open Access Journals (Sweden)

    Bárbara O González Navarro

    2014-01-01

    Full Text Available Título corto: Primera incursión en la obtención de curieles SPF en Cuba Título en ingles: First foray into the production of specific pathogen-free guinea pigs in Cuba Resumen: Resultados confiables y económicos solo son obtenidos cuando los animales de experimentación son aislados de factores ambientales y biológicos, implantándose en el biomodelo una microbiota normal, lejos de la presencia de microorganismos patógenos. El objetivo de la investigación fue obtener curieles libre de patógenos específicos por cesárea aséptica, mantenidos en aisladores y alimentados con dietas estériles. Se realizaron 26 histerectomías. Los animales fueron alimentados con una fórmula modificada (L-477 en forma de papilla hasta los 21 días y permanentemente después la C-484 sólida y granulada, esterilizadas a 121oC/20 minutos o a 1,5Mrad. Además fueron suplementados con vitamina C y B1. El forraje o heno fue consumido a partir de la primera generación. La microbiota gastrointestinal se administró por vía oral en 0,5 ml de una dilución de 10-6/g de contenido de la porción final del íleon, ciego y principio del colon de curieles, a las 24 y 48 horas del nacimiento. Se utilizó para el monitoreo microbiológico caldo Tioglicolato, caldo Triptona Soya y caldo Saboraud incubados aeróbicamente a temperatura de 55, 37y 25oC respectivamente. Se obtuvieron 51 neonatos. La mortalidad más alta se registró entre los primeros 10 días de edad (58,8%. Se lograron 12 animales (3 machos y 9 hembras, 6 de las hembras se reprodujeron aproximadamente a los 9 meses de edad, lográndose 11 crías por parto normal. La metodología aplicada permitió obtener curieles libres de Salmonella sp, Pasteurella sp, Streptococcus del tipo A y C, Bordetella bronchiseptica, Toxoplasma gondii, Virus Sendai y parásitos internos y externos. Palabras clave: curieles, libre de patógenos específicos, aisladores, histerectomía y dietas estériles. Abstract

  10. Raspad SFRJ: kriza, erozija, pat

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    Vladimir Petrović

    2015-02-01

    Full Text Available The article is scrutinizing stages of disintegration of SFRY, from the crisis which characterized the 80s to erosion heralded with the disintegration of LCY and realignment of political players during 1990. The collision between leaderships of republics, which produced divisions within the state Presidency, as well as collision between the Presidency, Federal Executive Council and the military is traced through the failed attempts to stop the erosion of the security situation in Yugoslavia at thte end of 1990 and beginning of 1991. Through the documents, media sources and the memories of participants, the article analyses activity and mutual raltions of key actors in the period of deepening og Yugoslav crisis in the direction of paralysis and violent disintegration of the state.

  11. The sensory acceptability of a tilapia (Oreochromis niloticus mechanically separated meat-based spread Aceitabilidade de patê à base de carne de tilápia (Oreochromis niloticus mecanicamente separada

    Directory of Open Access Journals (Sweden)

    Daniela De Grandi Castro Freitas

    2012-06-01

    Full Text Available Mechanically Separated Meat (MSM is an alternative for the diversification of new fish-based products and also as a solution for the use of waste from the filleting industries. Tilapia MSM was used in this study for the formulation of a fish spread aimed at investigating its acceptability by consumers. Two spread formulations were prepared with different types of commercial salt: seasoned salt (A and common salt (B. The consumers (112 evaluated their acceptance with respect to overall impression, spreadability, appearance and flavour acceptability on a 9-point hedonic scale. A microbiological analysis of the Tilapia MSM was also carried out and the chemical composition of the Tilapia MSM-based spread determined. When considering the acceptance of all the consumers, the overall impression, appearance and flavour were significantly (P A carne mecanicamente separada (CMS é uma alternativa para a diversificação de novos produtos à base de pescado e também se mostra como um destino para os resíduos da indústria de filetagem. A carne mecanicamente separada de tilápia foi utilizada, neste estudo, na formulação de patê, com o objetivo de investigar a aceitabilidade desse produto pelos consumidores. Duas formulações de patê foram preparadas, com diferentes tipos de sais comerciais: sal temperado (A e sal comum (B. Consumidores (112 avaliaram a aceitação em relação à impressão global, à espalhabilidade, à aparência e ao sabor em escala hedônica de nove pontos. A análise microbiológica da carne mecanicamente separada de tilápia e a composição química da formulação de patê de tilápia também foram determinadas. Quando a aceitação de todos os consumidores foi considerada, a impressão global, a aparência e o sabor foram significativamente (p < 0,05 inferiores para o patê de tilápia com sal comum (B. No entanto, três diferentes grupos de consumidores foram encontrados a partir da aceitabilidade da impressão global do

  12. Presencia de sistemas de secreción de patógenos en bacterias endosimbióticas aisladas de Lupinus de la península Ibérica

    OpenAIRE

    Pastor, Víctor; Iglesias, Ana Isabel; Duran Wendt, David Ricardo; Rey Navarro, Luis

    2012-01-01

    Los rizobios son bacterias endosimbióticas capaces de fijar nitrógeno en estructuras especializadas de leguminosas. Esta simbiosis es altamente específica y depende, entre otros factores, de la capacidad de los rizobios de secretar proteínas efectoras a las células vegetales. Se han descrito diferentes sistemas de secreción en patógenos animales y vegetales y posteriormente también se han encontrado en algunos rizobios. En este trabajo se presenta el estudio de varios sistemas de secreción id...

  13. Contaminación con bacterias patógenas de estetoscopios del personal médico en un hospital de nivel III en Lima, Perú

    OpenAIRE

    Oliva-Menacho, José Enrique; García-Hjarles, Marco Antonio; Oliva-Candela, José Arturo; De la Cruz-Roca, Hugo Saturnino

    2016-01-01

    Objetivos: Determinar el grado de contaminación bacteriana con bacterias patógenas de los estetoscopios del personal médico en un hospital general de Lima, Perú. Material y métodos: Estudio de tipo observacional, descriptivo y transversal, realizado en el Hospital Nacional Arzobispo Loayza, entre los meses de enero y juniodel 2013. Se estudiaron 124 muestras de estetoscopios del personal médico en las siguientes áreas: UCI 20; neonatología 13; quemados 3; medicina 52; emergencia 36. Se recole...

  14. Parásitos patógenos en arena de playa y su relación con condiciones ambientales, en un balneario de Puerto Cabello, Venezuela, 2012-2013

    OpenAIRE

    Guerrero De Abreu, Arli Marlinet; Quiñones O, María Virginia; Sequera P, Ernesto José; Marín Franco, José Luis

    2014-01-01

    Venezuela, presenta una gran variedad de playas frecuentadas durante todo el año, por lo que legalmente se establece un monitoreo permanente de niveles de contaminación para su clasificación "apta" o no para bañistas. Sin embargo, esto no contempla la evaluación parasitológica en la arena de playa como criterio para la referida clasificación. Por ello, la presencia de sólo una forma parasitaria patógena indica que existe contaminación fecal dado por personas, animales o acúmulo de basura a lo...

  15. Variação da contagem de células somáticas em vacas leiteiras de acordo com patógenos da mastite Somatic cell counts variation in dairy cows according to mastitis pathogens

    Directory of Open Access Journals (Sweden)

    G.N. Souza

    2009-10-01

    Full Text Available Avaliou-se o efeito de patógenos da mastite sobre a contagem de células somáticas (CCS em leite. Foram coletadas 3.987 amostras de leite de 2.657 animais oriundos de 24 rebanhos leiteiros localizados nos estados do Rio de Janeiro e Minas Gerais. As amostras de leite foram usadas para CCS e identificação de patógenos da mastite. Estatísticas descritivas, teste T para amostras independentes e modelo linear generalizado foram usados para análise dos dados. O modelo linear generalizado identificou os efeitos de rebanho, animal dentro de rebanho, ordem de parto, estação do ano e infecção intramamária causada por Streptococcus agalactiae e Streptococcus spp. que não S. agalactiae como significativos na variação da CCS. O efeito de animal dentro de rebanho foi maior que o efeito de rebanho. S. agalactiae foi o patógeno responsável pelo maior aumento da CCS em vacas e apresentou em média 1.520.000 células/mL. Foi observado efeito específico dos patógenos na variação da CCS.The influence of mastitis pathogens on variation of milk somatic cell count (SCC was evaluated. Three thousand nine hundred eighty-seven milk samples were colected from 2,657 dairy cows in 24 herds located in the states of Minas Gerais and Rio de Janeiro. The milk samples were used to SCC and identification of mastitis pathogens. Descriptive statistics, T test for independent samples, and generalized linear model were used to data analysis. The generalized linear model identified the effects of herd, animal within herd, parity, year season, intramammary infection, and infection caused by Streptococcus agalactiae and Streptococcus spp. except S. agalactiae as significant on SCC variation. The effect of animal within herd was higher than the effect of herd. S. agalactiae was the pathogen responsible for higher SCC increasing and presented the average of 1,520,000 cells/mL. The specific effect on SCC variation was observed in the study.

  16. Caracterización petrográfica, geoquímica y geocronológica en rocas ígneas intrusivas de la cuenca Cauca-Patía (CCP), Departamento del Cauca, Colombia

    OpenAIRE

    Jerez Heredia, Edith Katherine

    2012-01-01

    Al sur de la Cuenca Cauca-Patía, en el departamento del Cauca, Colombia, afloran once cuerpos intrusivos neógenos cuya composición varía de diorita, granodiorita a granito. La composición química de los granitoides muestreados presenta afinidad calcoalcalina, calcoalcalina alta en potasio y toleítica, dentro del rango de los granitoides cordilleranos tipo I. Según el análisis de datos geocronológicos se infieren tres eventos plutónicos que afectaron el área durante el Oligoceno-Mioceno inferi...

  17. Caracterização fenotípica e molecular de genitores de feijão tipo carioca quanto à resistência a patógenos Phenotypic and molecular characterization of genitors of carioca-type common bean regarding their resistance to pathogens

    Directory of Open Access Journals (Sweden)

    Carlos Lasaro Pereira de Melo

    2008-04-01

    Full Text Available O objetivo deste estudo foi a caracterização fenotípica e molecular de 31 genótipos de feijão do tipo carioca, quanto à resistência aos patógenos da antracnose, ferrugem e mancha-angular. Foram realizadas inoculações com 13 patótipos de Colletotrichum lindemuthianum, dois de Uromyces appendiculatus e sete de Pseudocercospora griseola. Na caracterização molecular, foram utilizados cinco marcadores moleculares previamente identificados, ligados a diferentes alelos de resistência aos patógenos. Sete genótipos apresentaram resistência a 12 patótipos de C. lindemuthianum. Nove genótipos apresentaram resistência a cinco patótipos de P. griseola. Dez genótipos foram resistentes aos patótipos de U. appendiculatus. As linhagens VC 2, VC 3 e VC 5, além da Rudá-R (linhagem piramidada com cinco genes que conferem resistência a alguns patótipos de antracnose, ferrugem e mancha-angular, foram as que se destacaram quanto à resistência múltipla aos patógenos acima citados. Foi detectado polimorfismo molecular entre a maioria dos genótipos com a Rudá-R, o que indica a possibilidade de uso dos marcadores moleculares SCARF10, SCARY20, SCARAZ20, SCARH13 e OPX11.The present study aimed at the phenotypic and molecular characterization of 31 genotypes of the carioca-type common bean regarding the resistance to anthracnose, rust and angular leaf spot (ALS pathogens. Thirteen pathotypes of Colletotrichum lindemuthianum, two of Uromyces appendiculatus and seven of Pseudocercospora griseola were inoculated. In the molecular characterization, five molecular markers, identified in advance, and linked to the different alleles of pathogens' resistance, were used. Seven genotypes showed resistance to 12 pathotypes of C. lindemuthianum. Nine genotypes presented resistance to five pathotypes of P. griseola. Ten genotypes were resistant to the pathotypes of U. appendiculatus. The lines VC 2, VC 3 and VC 5, besides Rudá-R (line pyramided with five

  18. Dermatófitos: interação patógeno-hospedeiro e resistência a antifúngicos Dermatophytes: host-pathogen interaction and antifungal resistance

    Directory of Open Access Journals (Sweden)

    Nalu Teixera de Aguiar Peres

    2010-10-01

    Full Text Available As micoses cutâneas estão entre as infecções mais comuns em humanos e se tornaram um importante problema de saúde pública, principalmente por causarem infecções invasivas em pacientes imunodeprimidos. Durante a infecção, a interação dermatófito-hospedeiro desencadeia adaptações metabólicas específicas que permitem aos patógenos aderirem e penetrarem no tecido, remodelando seu metabolismo para captar nutrientes e superar os mecanismos de defesa do hospedeiro. Esse remodelamento metabólico e a inter-relação entre metabolismo, morfogênese e resposta ao estresse são importantes fatores que estão sendo intensamente avaliados em diversos patógenos. As células do hospedeiro também respondem aos estímulos do patógeno, ativando vias de sinalização intracelular que culminam no desencadeamento de uma resposta imune contra o agente infeccioso. O entendimento molecular dessas respostas metabólicas pode ajudar no estabelecimento de novas estratégias terapêuticas. Nesta revisão, são abordados diferentes aspectos da biologia dos dermatófitos, com ênfase na interação dermatófito-hospedeiro e nos mecanismos de resistência a antifúngicos.Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host defense mechanisms. This metabolic shift and the interplay between metabolism, morphogenesis and stress response are important factors that have been extensively studied in several pathogens. Host cells also respond to the pathogen stimuli by activating intracellular signaling pathways that trigger the immune response against the infectious agent. The comprehension of the molecular aspects of these

  19. Análisis proteómico de la resistencia inducida por micorrización al patógeno foliar Sclerotinia sclerotiorum en frijol (Phaseolus vulgaris l.)

    OpenAIRE

    Quintero Zamora, Edalhí

    2014-01-01

    En los últimos años se han reportado diversos estudios sobre la resistencia inducida por micorrización al ataque de patógenos, en éstos se han determinado los cambios de expresión de genes y proteínas que ocurren en las raíces de plantas colonizadas por hongos micorrízicos arbusculares. Recientemente, se han iniciado estudios para entender cómo afecta esta interacción a la parte aérea de la planta. En nuestro grupo de investigación se llevó a cabo el estudio del efecto de la micorrizaci...

  20. Avaliação da estabilidade e da qualidade do patê de presunto, adicionado de globina bovina e de caseinato de sódio, como agente emulsionante

    OpenAIRE

    Silva Janaína Guernica; Morais Harriman Aley; Junqueira Roberto Gonçalves; Oliveira Afonso de Liguori; Silvestre Marialice Pinto Coelho

    2003-01-01

    Este trabalho foi conduzido para avaliar o efeito da incorporação das globinas bovina extraída pelo método da acetona acidificada (GT) e pelo da carboximetilcelulose (GCMC) e do caseinato de sódio (CA) sobre a composição química e as qualidades microbiológica e sensorial do patê de presunto. Foi, ainda, avaliada a estabilidade do produto durante os 45 dias de estocagem sob refrigeração, por meio das determinações de pH e do grau de oxidação lipídica. De acordo com os resultados obtidos, pôde-...

  1. "The Day All of the Different Parts of Me Can Come Along": Intersectionality and U.S. Third World Feminism in the Poetry of Pat Parker and Willyce Kim.

    Science.gov (United States)

    Van Ausdall, Mimi Iimuro

    2015-01-01

    This article brings to light the poetry of Pat Parker and Willyce Kim, two key figures within the 1970s and '80s women in print movement. While Parker and Kim have been rightly placed within African-American and Asian-American histories, respectively, and working-class and lesbian-feminist literary histories, their work is most fully understood within the context of U.S. Third World Feminism. Through close readings of poetic form and content in addition to engagement with current debates about intersectionality as a methodology, the article links Kim and Parker's works to central contributions of U.S. Third World Feminism such as intersectionality and power across and within difference that continue to influence feminist theory today.

  2. Terrain Sumbission for Howard County NE

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

  3. Michael Howard: Military Historian and Strategic Analyst.

    Science.gov (United States)

    1983-06-10

    eighties it became obvious that "the growing acceptability of mili- tary studies" was a consequence of a careful nurturing during the embryo stage by...would decide the destiny of the nation. If the machine gun and the artillery piece meant the "battle went on for longer than expected; the casualties

  4. DCS Hydraulics Submission for Howard County, IA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  5. Base Map Submission for Howard County, Iowa

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  6. Howard Hughes Medical Institute dose assessment survey

    International Nuclear Information System (INIS)

    O'Brien, S.L.; McDougall, M.M.; Barkley, W.E.

    1996-01-01

    Biomedical science researchers often express frustration that health physics practices vary widely between individual institutions. A survey examining both internal and external dose assessment practices was devised and mailed to fifty institutions supporting biomedical science research. The results indicate that health physics dose assessment practices and policies are highly variable. Factors which may contribute to the degree of variation are discussed. 2 tabs

  7. Didactica de las artes visuales sustentada en la propuesta de las inteligencias multiples de howard gardner: Experiencia aplicada en un primer año medio de la comuna de Concepción

    Directory of Open Access Journals (Sweden)

    Bernarda Larenas Parra

    2005-07-01

    Full Text Available Para revertir la actual situación que vive en nuestro país la enseñanza de las artes visuales y concretar una renovada orientación de esta disciplina, se hace indispensable crear nuevos planteamientos curriculares, donde el aprender se transforme en un camino de búsqueda interdisciplinar, por medio de metodologías interactivas, participativas y estimuladoras que le otorgan al alumno la conformación de un ser integral. Es por ello que este estudio propone una nueva forma de adquisición del conocimiento, que consiste en la creación de una estrategia metodológica que permita desarrollar la capacidad artística en la enseñanza de las artes visuales a partir de una intervención didáctica, sustentada en la propuesta de las Inteligencias Múltiples del neuropsicólogo norteamericano Howard Gardner. Los resultados arrojados en esta investigación fueron elocuentes. La aplicación de esta nueva estrategia metodológica no sólo contribuyó a desarrollar significativamente lacapacidad artística en los alumnos, sino que además les permitió fortalecer la interacción cognitiva y afectiva entre ellos durante dicho proceso educativo, fomentar labúsqueda consciente de alternativas de solución para dar respuesta al desafío propuesto, potenciar el nivel de creatividad y sensibilidad estética, etc. Queda de manifiesto que la asignatura de Artes Visuales tiene un importante papel que jugar en la puesta en práctica de una educación integral, que no sólo atienda a los contenidos intelectuales. Por otra parte, tiene mucho que decir en una educación que mira al futuro, que persigue el aprender a aprender, que busca potenciar la capacidad de resolver problemas complejos y nuevos, que demanda desarrollar el pensamiento creativo y lacapacidad de proporcionar respuestas múltiples ante situaciones complejas. En ese sentido, las Artes Visuales coinciden con las pretensiones de las modernas tendencias pedagógicas que intentan pensar qué educaci

  8. Emergência de Haematobia irritans em fezes bovinas no município de Seropédica, Rio de Janeiro Emergence of Haematobia irritans in cattle dung pats in Seropédica county, Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Douglas Marques de Macedo

    2001-06-01

    Full Text Available O presente trabalho teve como objetivo estudar a emergência de Haematobia irritans em fezes de bovinos mantidas a campo e em laboratório, além de observar a presença de outros dípteros associados às massas fecais. Foram utilizados dois grupos de fezes bovinas, um à campo e outro em laboratório, sendo cada grupo formado por cinco bolos fecais frescos de tamanho mediano (cerca de 30 cm de diâmetro, aparência opaca, cor esverdeada, presença de fina crosta externa e consistência firme. As fezes foram cobertas com gaiolas de emergência de formato piramidal, apresentando na parte superior um orifício onde foi acoplado um frasco removível; a substituição das fezes foi realizada quinzenalmente. Foram coletados um total de 355 espécimens de H. irritans, sendo 151 provenientes das gaiolas mantidas no campo e 204 em laboratório. Estas diferenças deveram-se provavelmente à menores oscilações de temperatura verificadas no laboratório do que àquelas ocorridas no campo, além da ação de artrópodes predadores, competidores e parasitóides que, provavelmente, interferiram na emergência de H. irritans nas fezes bovinas mantidas no campo. Foi observado maior número de fêmeas em comparação com machos em ambas as condições investigadas. Além de H. irritans, obteve-se outros dípteros associados às fezes bovinas, pertencentes as seguintes famílias: Aulacigastridae, Muscidae, Psychodidae, Sarcophagidae, Sepsidae, Tachinidae e Ulidiidae. Sepsidae foi a mais abundante, com 5.224 exemplares do total de 8.928 dípteros obtidos, seguida por Sarcophagidae com 2.235 espécimens coletados, Muscidae com 1.357, Aulacigastridae com 54, Psychodidae com 46, Ulidiidae com 6 e Tachinidae com 5 exemplares.This study was carried out in order to investigate the emergence of adult flies of Haematobia irritans in cattle dung maintained in the field and in the laboratory, as well as other flies associated with dung pats. Two groups of cattle dung were

  9. Incidência de patógenos e vigor de sementes de milho doce submetidas a danos mecânicos Pathogen incidence and vigor in sweet corn seed after mechanical damage

    Directory of Open Access Journals (Sweden)

    Francisco Guilhien Gomes Junior

    2009-09-01

    Full Text Available Com o objetivo de avaliar a incidência de patógenos e o vigor de sementes de milho doce de diferentes classes de tamanhos submetidas a diferentes níveis de danos mecânicos, sementes do híbrido 'SWB551' Dow AgroSciences® foram classificadas em peneiras com crivos de diferentes tamanhos e formas (RG, RM1, RM2 e RP com crivos circulares de 8,7; 7,9; 7,1 e 6,4 mm de diâmetro, respectivamente, e CG, CM e CP com crivos oblongos com dimensões de 8,7 x 19,0, 7,9 x 19,0, 6,4 x 19,0 mm, respectivamente, submetidas a impactos contra uma placa metálica de maneira que fossem obtidos tratamentos com diferentes intensidades de danos mecânicos (0, 1, 3, 5 e 7 impactos e armazenadas por 5 meses em ambiente com temperatura de 20ºC e 50-60% de umidade relativa do ar. Foi utilizado o delineamento inteiramente casualizado, com quatro repetições, perfazendo um fatorial 7 x 5 (7 peneiras x 5 intensidades de danos, totalizando 35 tratamentos. Foram realizadas as avaliações de teor de água das sementes, teste de danos mecânicos (tintura de iodo, teste de germinação, teste de frio e teste de sanidade. Foram evidenciadas variações nos níveis de incidência de patógenos entre as sementes de milho doce com diferentes tamanhos e formas. O aumento da intensidade dos danos mecânicos não favoreceu o aumento da incidência de patógenos nas sementes, mas reduziu o vigor das mesmas.The objective of this study was to evaluate pathogen incidence and vigor in different size classes of sweet corn seeds, after mechanical damage. Hybrid seeds 'SWB551' Dow AgroSciences® were classified by sieves with different sizes and forms (RG, RM1, RM2 and RP, with circular sieves of 8.7, 7.9, 7.1 and 6.4 mm of diameter, respectively, and CG, CM and CP with oblong sieves with dimensions of 8.7 x 19.0, 7.9 x 19.0, 6.4 x 19.0 mm, respectively. Seeds were submitted for impacts against a metallic plate in order to have different intensities of mechanical damage (0, 1, 3, 5 and

  10. Survival of pathogens on soybean debris under no-tillage and conventional tillage systems Sobrevivência de patógenos em restos de cultura de soja mantidos em sistema de semeadura direta e convencional

    Directory of Open Access Journals (Sweden)

    Álvaro Manuel Rodrigues Almeida

    2001-10-01

    Full Text Available A study was conducted in the subtropical area of Southern Brazil to determine the survival of pathogens in soybean residues under conventional and no-tillage cultivation systems from March to September of 1998 and 1999. The pathogens most frequently isolated were Colletotrichum truncatum, Phomopsis spp., Cercospora kikuchii, Fusarium spp., Macrophomina phaseolina, and Rhizoctonia solani. Other fungi isolated were Myrothecium roridum, Penicillium sp., Chaetomium sp., Epicoccum sp., Corynespora cassiicola and Trichoderma sp. The percent of survival of each pathogen varied according to the month and the year. Survival of C. truncatum, Phomopsis spp. and C. kikuchii were significantly reduced (pAvaliou-se a sobrevivência de patógenos em restos de soja, em sistema de semeadura direta e convencional, entre março e setembro de 1998 e 1999, em Londrina, PR. Os patógenos mais freqüentemente isolados foram Colletotrichum truncatum, Phomopsis spp., Cercospora kikuchii, Fusarium spp., Macrophomina phaseolina e Rhizoctonia solani. Outros fungos isolados foram Myrothecium roridum, Penicillium sp., Chaetomium sp., Epicoccum sp., Corynespora cassiicola e Trichoderma sp. A porcentagem de sobrevivência variou com o mês e o ano. A sobrevivência de C. truncatum, Phomopsis spp. e C. kikuchii foi significativamente reduzida (P<0,05 entre a primeira e última avaliação nos resíduos mantidos sobre ou sob o solo. M. phaseolina e Fusarium spp. não foram afetados, ou foram favorecidos pelo enterro dos resíduos. A freqüência de isolamento de Fusarium spp. aumentou em resíduos enterrados no solo. A perda de biomassa mostrou redução de 44,4% no sistema convencional e 34,9% no sistema de semeadura direta, em 1998, quando a distribuição de chuvas foi mais regular. Em 1999, a redução foi de 48,2% e 39,0% para os sistemas convencional e de semeadura direta, respectivamente.

  11. America's Teacher Colleges: Are They Making the Grade? Hearing before the Subcommittee on 21st Century Competitiveness of the Committee on Education and the Workforce. House of Representatives, One Hundred Eighth Congress, First Session (May 20, 2003).

    Science.gov (United States)

    Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

    A hearing was held to explore whether U. S. teachers' colleges are doing an adequate job. Opening statements by Representative Howard P. McKeon and Representative Dale Kildee set the stage for the testimony of these witnesses: (1) Lisa Graham Keegan, Chief Executive Officer, Education Leaders Council; (2) Kati Haycock, Director, The Education…

  12. Pārdošanas veicināšanas paņēmienu ietekme uz patērētājiem Latvijā un Beļģijā

    OpenAIRE

    Limane, Marianna

    2010-01-01

    Bakalaura darba tēma ir „Pārdošanas veicināšanas paņēmienu ietekme uz patērētājiem Latvijā un Beļģijā”. Pārdošanas veicināšanas pasākumu izmantošana mērķtiecīgi palielinājusies kopš 1960tajiem gadiem un šobrīd tā ir kļuvusi par galveno mārketinga komunikāciju kompleksa sastāvdaļu. Izmantotās metodes kļūst arvien sarežģītākas un arvien vairāk uzņēmumu izprot labi izplānotu pārdošanas veicināšanas kampaņu nozīmību. Bakalaura darba mērķis ir izpētīt kuras no pārdošanas veicināšanas metodēm u...

  13. Selección de rizobacterias por su antagonismo frente a microorganismos patógenos de cucurbitáceas /Screening of rhizobacteria for their antagonism against microbial pathogens of cucurbits.

    Directory of Open Access Journals (Sweden)

    Gilda Jiménez Montejo

    2014-04-01

    Full Text Available Resumen:El desarrollo de inoculantes microbianos a partir de aislamientos de rizobacterias con potencial para el control biológico de enfermedades de los cultivos agrícolas requiere de una rigurosa selección. Se obtuvieron aislamientos bacterianos de la rizosfera de papa (Solanum tuberosum L. y de maíz (Zea mays L. y de semillas de frijol (Phaseolus vulgaris L.. Las colonias que mostraron in vitro halos de inhibición de los patógenos de cucurbitáceas: Xanthomonas cucurbitae, Acidovorax avenae subsp. citrull y Fusarium oxysporum, se seleccionaron como antagonistas. A partir de las características morfológicas, fisiológicas y bioquímicas las cepas antagonistas F16/95 y Xph se identificaron con la especie Bacillus subtilis y la cepa 14A como Pseudomonas putida. Las pruebas presuntivas de producción de antibiocinas in vitro sugirieron modos de acción de las rizobacterias relacionados con antibiosis y competencia por el hierro mediante la producción de sideróforos. Los resultados indicaron el potencial de las cepas de rizobacterias antagonistas Bacillus subtilis (F16/95, Xph y Pesudomonas putida 14A para el control biológico de enfermedades de las cucurbitáceas./Abstract:

  14. Ação antagônica e de metabólitos bioativos de Trichoderma spp. contra os patógenos Sclerotium rolfsii e Verticillium dahliae

    Directory of Open Access Journals (Sweden)

    Carolina Oliveira Isaias

    2014-03-01

    Full Text Available O efeito antagônico exercido por fungos do gênero Trichoderma foi avaliado contra os fitopatógenos Sclerotium rolfsii e Verticillium dahliae, isolados de áster ornamental e morangueiro, respectivamente. Utilizaram-se 20 isolados do antagonista, pertencentes às espécies T. asperellum, T. hamatum, T. harzianum, T. koningiopsis, T. spirale e Trichoderma sp. O antagonismo foi verificado por meio de testes de culturas pareadas e produção de metabólitos bioativos pelo método de sobreposição de placas. A maioria dos isolados exibiu efeito inibitório sobre o crescimento micelial de S. rolfsii e V. dahliae quando comparado com as testemunhas. Excetuando-se os testes de produção de metabólitos não-voláteis, verificou-se maior ação inibitória contra V. dahliae. Mesmo os metabólitos não-voláteis termoestáveis apresentaram efeito inibitório contra ambos os patógenos testados, mostrando que os metabólitos secundários do antagonista exercem efeito significativo sobre essas espécies patogênicas.

  15. Sperm FISH analysis of a 44,X,der(Y),t(Y;15)(q12;q10)pat,rob(13;14)(q10;q10)mat complex chromosome rearrangement.

    Science.gov (United States)

    Ferfouri, F; Boitrelle, F; Clement, P; Molina Gomes, D; Selva, J; Vialard, F

    2014-06-01

    Complex chromosome rearrangements (CCR) with two independent chromosome rearrangements are rare. Although CCRs lead to high unbalanced gamete rates, data on meiotic segregation in this context are scarce. A male patient was referred to our clinic as part of a family screening programme prompted by the observation of a 44,X,der(Y),t(Y;15)(q12;q10)pat,rob(13;14)(q10;q10)mat karyotype in his brother. Karyotyping identified the same CCR. Sperm FISH (with locus-specific probes for the segments involved in the translocations and nine chromosomes not involved in both rearrangements) was used to investigate the rearrangements meiotic segregation products and establish whether or not an inter-chromosomal effect was present. Sperm nuclear DNA fragmentation was also evaluated. For rob(13;14) and der(Y), the proportions of unbalanced products were, respectively, 26.4% and 60.6%. Overall, 70.3% of the meiotic segregation products were unbalanced. No evidence of an inter-chromosomal effect was found, and the sperm nuclear DNA fragmentation rate was similar to our laboratory's normal cut-off value. In view of previously published sperm FISH analyses of Robertsonian translocations (and even though the mechanism is still unknown), we hypothesise that cosegregation of der(Y) and rob(13;14) could modify rob(13;14) meiotic segregation. © 2013 Blackwell Verlag GmbH.

  16. Portāla YouTube patēriņa paradumi un lietošanas motivācija vidusskolas vecuma jauniešu vidū

    OpenAIRE

    Krastiņa, Lāsma

    2016-01-01

    Bakalaura darba „Portāla Youtube patēriņa paradumi un lietošanas motivācija vidusskolas vecuma jauniešu vidū” mērķis ir veicot padziļinātās intervijas un anketēšanu noskaidrot kādām darbībām portāls Youtube galvenokārt tiek izmantots un kādi ir tā izmantošanas paradumi un motivācija Latvijas vidusskolas vecuma jauniešu vidū. Darbs sastāv no 7 nodaļām. Teorētisko daļu sastāda nodaļas par Web 2.0, portālu Youtube, lietojuma un apmierinātības teoriju, bērnu un jauniešu interneta lietojumu. Metod...

  17. Linguistic Norms at the Crossover: The Verbal Tenses and Modes, and the Structure of the Predicate in «Libro decimosexto» from Comentarios de erudición by Bartolomé Jiménez Patón

    Directory of Open Access Journals (Sweden)

    Juan Miguel Monterrubio Prieto

    2013-11-01

    Full Text Available This study examines verb modes and tenses as well as the predicate structure in «Libro decimosexto» of Bartolomé Jiménez Patón’s Comentarios de erudición in an effort to demonstrate how the text straddles the line between Medieval and Golden Age norms. Jiménez Patón, thus, combines traits already considered archaic at the time, due perhaps to his solid training in grammar and his linguistic awareness, with those modern solutions which, towards the end of the 1500’s, were forging the new Spanish language (that of the «plain style», which he championed, one that was gradually being refined in order to take its place as the language of culture.

  18. Pārdošanas veicināšana kā patērētāju uzvedības un lēmumu pieņemšanas ietekmētājs Latvijas pārtikas mazumtirdzniecības nozarē.

    OpenAIRE

    Afoņičeva, Oksana

    2016-01-01

    Maģistra darba: “Pārdošanas veicināšana kā patērētāju uzvedības un lēmumu pieņemšanas ietekmētājs Latvijas pārtikas mazumtirdzniecības nozarē” mērķis ir, izvērtējot pārdošanas veicināšanas ietekmi uz patērētāju uzvedību, lēmuma pieņemšanas procesu un uz patērētāju lojalitātes veidošanu, rast priekšlikumus pārdošanas veicināšanas iespējām pārtikas produktu zīmoliem. Darbs sastāv no četrām nodaļām- divām teorētiskajām, analītiskās un empīriskās. Pirmā izvirzītā hipotēze tiek apstiprināta, pama...

  19. Patērētāju uzvedības pētījums par ēdienu piegādes portālu Hungryhouse.co.uk kā e-komercijas dalībnieku.

    OpenAIRE

    Dembovska, Gerda

    2013-01-01

    Darba tēma -patērētāju uzvedības pētījums par ēdienu piegādes portālu Hungryhouse.co.uk kā e-komercijas dalībnieku. Autore apraksta patērētāja uzvedības izpētes un e-komercijas teorētiskos aspektus,analizē uzņēmuma Hungryhouse.co.uk. darbību Lielbritānijā,veic aptauju par Hungryhouse.co.uk.pastāvēšanas iespējām Latvijā. Darba mērķis -pamatojoties uz patērētāju uzvedības un e-komercijas teorētiskām atziņām,kā arī uz iedzīvotāju aptaujas rezultātiem, izpētīt ēdiena piegādes portāla Hungryho...

  20. Drama in the Dale: Transformation through Community Drama

    Science.gov (United States)

    Ward, Julie; Mills, Helen Frances; Anderson, Alan

    2013-01-01

    During the winter of 2011-2012, Weardale, England, was the setting for an ambitious informal adult education project. In this rural area in the northeast part of the country, the local arts collective, Jack Drum Arts, established a community play project entitled "The Bonny Moorhen." This dramatic undertaking aimed to retell the story of…

  1. CLIL activities by Liz Dale and Rosie Tanner

    OpenAIRE

    Simpson, Adam John

    2012-01-01

    Ever since David Marsh and Anne Maljers ushered in the era of CLIL in 1994, this new methodology has remained a source of hot debate in ELT. While many teachers are suspicious of or indeed resistant to the very notion of Content and Language Integrated learning, others view it as the future of language teaching. For those unfamiliar with the concept, CLIL is an approach which aims to marry the learning of content to the acquisition of an additional language, thus teaching both the subject and...

  2. De daling van het aantal verkeersdoden in 2004 nader geanalyseerd.

    NARCIS (Netherlands)

    Weijermars, W.A.M. Bijleveld, F.D. & Stipdonk, H.L.

    2011-01-01

    Further analysis of the decrease in the number of road fatalities in 2004. The numbers of road fatalities as well as the risk of dying in a road crash have been showing a downward trend. In 2004, the number of fatalities and the crash rate showed a relatively strong decline. In the present report

  3. Book Review: Caves and Karst of the Yorkshire Dales

    Science.gov (United States)

    Westaway, Rob

    2015-10-01

    The British Cave Research Association (BCRA) is the research division of the British Caving Association (BCA), itself the principal society in Britain for those interested in caving, with activities including provision of training and safety certification for cavers and managing access to caves. Although some UK cave-related research is carried out by academics, this tends to be restricted to archaeological investigations of caves that have served as human habitations, and to be focused more on the occupants than the caves themselves. In contrast, most cave exploration is undertaken as a leisure activity, under the auspices of clubs affiliated to the BCA/BCRA, this being indeed virtually the only field of Earth science where amateur investigators can continue to make significant discoveries. Many cave explorers are also affiliated with academic researchers, such as managers of dating laboratories; the synergy between these two groups is highly productive, having resulted for instance in the discovery and exploration in recent years of the vast Ogof Draenen cave system in South Wales, which probably dates back to the Early Pleistocene (e.g., Farrant et al., 2014).

  4. Efecto de las altas presiones hidrostáticas respecto a la pasteurización térmica en los aspectos microbiológicos, sensoriales y estabilidad oxidativa de un paté de aceituna

    Directory of Open Access Journals (Sweden)

    Sánchez, J.

    2012-03-01

    Full Text Available The present study examines the effect of high hydrostatic pressure processing (HHP as an alternative to thermal pasteurization treatments for the conservation of olive pate and its stability during refrigerated storage, through the characterization of microbiological, physico-chemical and sensory aspects. The olive pate was made with green, pitted table olives packed in brine. Orange juice, olive oil, spices and potassium sorbate were added to the olives after being washed in water. To evaluate the effects of processing, four treatments of APH (450 and 600MPa for 5 and 10 min and a thermal pasteurization (80 °C for 20 min were applied to compare them with the unprocessed product. APH-treated samples showed a further reduction in the presence of microorganisms, an increase in oxidative stability, a higher sensory acceptance, greater clarity and less browning regarding the colorimetric coordinates, in comparison with those treated by thermal pasteurization. The study of the shelf life of the product in refrigeration would indicate the feasibility to implement APH technology in order to obtain food with a similar shelf life to foods obtained through the traditional thermal pasteurization treatment, but with better sensory quality.

    En el presente trabajo se valoró el efecto del procesado por altas presiones hidrostáticas (APH como método alternativo al tratamiento térmico de pasteurización para la conservación del paté de aceituna y su estabilidad durante el almacenamiento en refrigeración, mediante la caracterización de los aspectos microbiológicos, físico-químicos y sensoriales. El paté de aceituna fue elaborado partiendo de aceituna de mesa verde deshuesada y envasada en salmuera, a la cual, previo lavado con agua, se le adiciona zumo de naranja natural, aceite de oliva virgen, especias y sorbato potásico. Para evaluar el efecto del procesado, se aplicaron cuatro tratamientos de APH (450 y 600MPa durante 5 y 10min y otro de

  5. Variability among pathologists in the histological diagnosis of helicobacter pylori infection: is it a subjective diagnosis? Variabilidad entre patólogos en el diagnóstico histológico de la infección por Helicobacter pylori: ¿un diagnóstico subjetivo?

    Directory of Open Access Journals (Sweden)

    Luis Fernando Arias Restrepo

    2006-01-01

    Full Text Available Histopathologic diagnosis of Helicobacter pylori (Hp infection is not necessarily easy, and reproducibility is not perfect. Our aim was to determine differences in the frequency of Hp infection according to the pathologists interpreting gastric biopsies in Medellín (Colombia. Materials and methods: All gastric biopsy reports of eight pathologists during one year were reviewed. We excluded cases with intestinal metaplasia, atrophy, dysplasia or carcinoma. We registered patient age, positivity or negativity for H. pylori, and pathologist. We determined the percentage with H. pylori infection and the percentage of each pathologist in order to determine differences. Results: 2.023 cases were included. Each pathologist evaluated a mean of 252.9 ± 154.9 cases (range: 102-445. Patients were 43.5 ± 15.1 years-old (range: 12-90. H. pylori was diagnosed in 1.034 cases (51.1%. The range of positivity according to the pathologist was 38.8-71.1%; mean 51.1% ± 8.7% (p < 0,001. Conclusion: Among pathologists, there is a significant variability in the frequency of diagnosis of H. pylori infection. This result suggests the need to achieve greater homogeneity of concepts and criteria for the diagnosis of this infection, and of its severity. El diagnóstico histológico de la infección por Helicobacter pylori (Hp puede ser difícil, principalmente en casos con pocos microorganismos. Nuestro objetivo fue determinar si hay diferencias significativas en la frecuencia del diagnóstico de la infección por Hp entre patólogos que laboran en Medellín. Materiales y métodos: revisamos todos los informes de biopsias gástricas de ocho patólogos durante un año. Excluimos las biopsias con metaplasia, atrofia, displasia o carcinoma. Registramos la edad del paciente, la presencia o ausencia de Hp y el patólogo que estudió la biopsia. Calculamos el porcentaje de casos con la infección y el porcentaje por patólogo. Finalmente, comparamos estos porcentajes para

  6. Detección y prevalencia de patógenos periodontales de una población con periodontitis crónica en Uruguay mediante metodología convencional y metagenómica

    Directory of Open Access Journals (Sweden)

    Virginia Papone

    Full Text Available Resumen Las enfermedades periodontales son un significativo problema mundial a nivel de salud humana. Décadas de investigaciones, evidencian que en la mayoría de los casos la periodontitis crónica es la más común, caracterizada por ser de evolución lenta, con formación de bolsas periodontales, posterior reabsorción del hueso alveolar, pérdida y destrucción de piezas dentarias y tejido óseo. Si bien se reconoce el origen multifactorial en el desarrollo de la periodontitis, es relevante la participación de la microbiota subgingival en la etiología de la enfermedad periodontal. Algunas de las especies bacterianas patógenas que han sido asociadas con el desarrollo de la enfermedad periodontal son Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Fusobacterium nucleatum, entre otras. En este estudio, nos propusimos investigar cuáles de éstas cinco especies estaban presentes en las bolsas periodontales de 51 pacientes uruguayos con periodontitis crónica. Para alcanzar éste objetivo se utilizó una técnica convencional microbiológica y metagenómica (multiplex-PCR. Los resultados de la técnica convencional microbiológica evidenciaron la presencia de A. actinomycetemcomitans (33% y de bacterias negras pigmentadas anaerobias (100% en las muestras. De los resultados obtenidos en la multiplex-PCR, se demostró que las especies de mayor prevalencia fueron F. nucleatum (100%, T. forsythia (92% y P. gingivalis (88%. Por el contrario, las especies de menor prevalencia fueron P. intermedia (39% y A. actinomycetemcomitans (33%

  7. Fungicidal activity of Eucalyptus tereticornis essential oil on the pathogenic fungus Fusarium oxysporum Actividad antimicótica del aceite esencial a partir de Eucalyptus tereticornis sobre el hongo patógeno Fusarium oxysporum

    Directory of Open Access Journals (Sweden)

    Walter Murillo Arango

    2011-06-01

    Full Text Available The objective of present paper was to determine the antifungal activity of the Eucalyptus tereticornis (Myrtaceae essential oil and two fractions on the Fusarium oxysporum mushroom, a pathogen with clinical and agricultural significance. The total citronelal (44.8 % and geraniol (9.78 % essential oil had a fungicidal effect at a 3 g/L concentration and a fungicidal activity at small concentrations. The A and B fractions composed most of p-mentane-3,8-diol (18.95 % and geraniol acetate (24.34 %, respectively were more active than the total extract. The observations at microscopic level showed damages and changes in hyphae and chlamydospores, as well as a decrease in the number of conidia. The observed fungicidal activity and the morphologic damages were dependent on the concentration.El objetivo de este trabajo fue determinar la actividad antifúngica del aceite esencial de Eucalyptus tereticornis (Myrtaceae y 2 fracciones sobre el hongo Fusarium oxysporum, patógeno de importancia tanto clínica como agrícola. El aceite esencial total, compuesto principalmente por citronelal (44,8 %, citronelol (9,78 % presentó un efecto fungicida a una concentración de 3 g/L y actividad fungistática a concentraciones menores. La fracciones A y B compuestas en su mayoría por p-mentano-3,8-diol (18,95 % y acetato de citronelol (24,34 % respectivamente fueron más activas que el extracto total. Las observaciones a nivel microscópico mostraron daños y cambios en hifas y clamidosporas, así como disminución en el número de conidias. La actividad fungistática observada y los daños morfológicos fueron dependientes de la concentración.

  8. Plantas e constituintes químicos empregados em Odontologia: revisão de estudos etnofarmacológicos e de avaliação da atividade antimicrobiana in vitro em patógenos orais

    Directory of Open Access Journals (Sweden)

    D.R.P. Vieira

    2014-03-01

    Full Text Available Produtos derivados de plantas podem representar estratégia promissora na odontologia. Desse modo, o objetivo deste trabalho foi levantar na literatura os estudos sobre o uso popular de plantas em afecções orais, bem como os estudos de avaliação da atividade antimicrobiana in vitro de extratos vegetais e compostos isolados sobre patógenos orais, no período de 1996 a 2011. Quarenta e sete famílias botânicas foram referidas, com maior número de citações para Anacardiaceae, sendo Anacardium occidentale L., a espécie mais citada. O levantamento sobre estudos de avaliação antimicrobiana relacionou extratos de sessenta e seis espécies vegetais pertencentes a trinta e oito famílias botânicas, destacando-se Anacardiaceae, com pesquisas realizadas de forma predominante com as folhas, investigadas pelo método de difusão em ágar. Cinquenta e oito substâncias isoladas de plantas foram avaliadas, demonstrando que Terminalia chebula Retz (Combretaceae representa a espécie vegetal com atividade antimicrobiana in vitro mais significativa, apresentando halo de inibição de 32,97 mm contra Staphylococcus aureus, microrganismo encontrado em infecções orais; enquanto ácido tetra iso-alfa isolada de Humulus lupulus L. (Canabinaceae apresentou maior halo de inibição para Streptococcus mutans (26,0 mm. Os resultados apresentados devem estimular o desenvolvimento dos estudos de validação na garantia do uso seguro e eficaz de espécies vegetais em odontologia.

  9. Nuclear power - a (too) pat solution

    International Nuclear Information System (INIS)

    Vester, F.

    1979-01-01

    This popular book in 'window' form attempts to give a picture of the complex economic and social consequences of a further development of nuclear power utilisation. The advantages of nuclear power are listed, and a critical balance is established for the negative consequences of an all-nuclear energy use for economy, environment, and society. (UA) 891 UA/UA 892 MKO [de

  10. Chemical and sensory quality of sheep liver pâté prepared with ‘variety meat’Qualidade química e sensorial de patê de fígado ovino elaborado com subprodutos comestíveis

    Directory of Open Access Journals (Sweden)

    Deborah Amaral

    2013-09-01

    Full Text Available Many edible meat by-products produced from sheep slaughter are often wasted but represent excellent sources of many nutrients. The preparation of pâté may be an alternative use for this raw material and may contribute to the development of a sheep sector by offering new products to the consumer market. The objective of this work was to produce and evaluate the quality of sheep pâté made with blood, liver and trimmed meat. The pâté formulation was composed of 12% meat, 25% liver, 13% blood, 20% water and 30% fat, as well as spices and seasoning. The product had high iron content (9.0 mg/100 g. The measured levels of essential amino acids exceeded the recommended values for adults. The sheep liver pâté showed a significant percentage of linoleic acid (16.68%, which is essential to the human body. The pâté produced was in accordance with the requirements of the Brazilian legislation regarding chemical and microbiological parameters, able to be edible, and showed good sensory acceptance. This study suggests that the development of sheep liver pâté is a viable alternative to add value to edible sheep slaughter by-products by generating a product with high nutritional value. Subprodutos comestíveis produzidos a partir do abate de ovinos são muitas vezes desperdiçado, mas representam excelentes fontes de muitos nutrientes. A preparação de patê pode ser uma alternativa para utilização desta matéria-prima e pode contribuir para o desenvolvimento do setor da ovinocultura, oferecendo novos produtos para o mercado consumidor. O objetivo deste trabalho foi produzir e avaliar a qualidade de patê ovino feito com fígado, sangue e retraços de carne. A formulação do patê foi composta de 12 % de carne, 25% de fígado, 13 % de sangue, 20% de água e 30% de gordura, bem como especiarias e condimentos. O produto tinha alto teor de ferro (9,0 mg/100 g. Os níveis medidos de aminoácidos essenciais excederam os valores recomendados para

  11. Principales características y diagnóstico de los grupos patógenos de Escherichia coli Diagnosis and main characteristics of Escherichia coli pathogenic groups

    Directory of Open Access Journals (Sweden)

    Guadalupe Rodríguez-Angeles

    2002-09-01

    Full Text Available Escherichia coli coloniza el intestino del hombre pocas horas después del nacimiento y se considera de flora normal, pero hay descritos seis grupos de E. coli productora de diarrea: enterotoxigénica (ETEC, enterohemorrágica (EHEC, enteroinvasiva (EIEC, enteropatógena (EPEC, enteroagregativa (EAEC y de adherencia difusa (DAEC. La bacteria se puede aislar e identificar tradicionalmente con base en sus características bioquímicas o serológicas, pero también se pueden estudiar sus mecanismos de patogenicidad mediante ensayos en cultivos celulares o modelos animales y, más recientemente, empleando técnicas de biología molecular que evidencian la presencia de genes involucrados en dichos mecanismos. La intención del presente trabajo es resaltar la importancia del estudio y diagnóstico de E. coli como patógeno capaz de causar casos aislados o brotes de diarrea, síndrome urémico hemolítico, colitis hemorrágica y cuadros de disentería, principalmente en niños; por esto es necesario conocer mejor a la bacteria y mantener la vigilancia epidemiológica.Escherichia coli colonizes the human intestinal tract within hours of birth and is considered a non-pathogenic member of the normal intestinal flora. However, there are six pathogenic groups that may produce diarrhea: enterotoxigenic (ETEC, enterohemorrhagic (EHEC, enteroinvasive (EIEC, enteropathogenic (EPEC, enteroaggregative (EAEC and diffusely adherent (DAEC groups. E. coli can be isolated and classified using traditional methods, by identifying its biochemical or serum characteristics. The pathogenic mechanisms may be studied in cell cultures and animal model assays, as well as more up to date molecular biology methods for study and diagnosis. The latter have proven that genes are involved in pathogenesis. The objective of the present work is to draw attention to the importance of E. coli as a pathogenic organism. This microorganism is an etiologic agent of sporadic cases of diarrhea

  12. Detection of putative periodontal pathogens in subgingival specimens of dogs Detecção de patógenos periodontais em amostras subgengivais de cães

    Directory of Open Access Journals (Sweden)

    Sheila Alexandra Belini Nishiyama

    2007-03-01

    Full Text Available In this study, the presence of putative periodontal organisms, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, Fusobacterium nucleatum,Dialister pneumosintes,Actinobacillus actinomycetemcomitans,Campylobacter rectus,Eikenella corrodens and Treponema denticola were examined from subgingival samples of 40 dogs of different breeds with (25 and without (15 periodontitis, by using the PCR method. The PCR products of each species showed specific amplicons. Of the 25 dogs with periodontitis, P. gingivalis was detected in 16 (64% samples, C. rectus in 9 (36%, A. actinomycetemcomitans in 6 (24%, P. intermedia in 5 (20%, T. forsythensis in 5 (20%, F. nucleatum in 4 (16% and E. corrodens in 3 (12%. T. denticola and D. pneumosintes were not detected in clinical samples from dogs with periodontitis. Moreover, P. gingivalis was detected only in one (6.66% crossbred dog without periodontitis. Our results show that these microorganisms are present in periodontal microbiota of dogs with periodontitits, and it is important to evaluate the role of these putative periodontal microorganisms play in the periodontitis in household pets particularly, dogs in ecologic and therapeutic terms, since these animals might acquire these periodontopahogens from their respective owners.Neste estudo, a presença de patógenos periodontais, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, Fusobacterium nucleatum, Dialister pneumosintes, Actinobacillus actinomycetemcomitans, Campylobacter rectus, Eikenella corrodens e Treponema denticola foi determinada por PCR, em amostras subgengivais de 40 cães com (25 e sem (15 doença periodontal. Os produtos amplificados pelo PCR para cada espécie bacteriana mostraram amplicons específicos. Dos 25 cães apresentando doença periodontal, P. gingivalis foi detectado em 16 amostras (64%, C. rectus em 9 (36%, A. actinomycetemcomitans em 6 (24%, P. intermedia em 5 (20%, T. forsythensis em 5 (20

  13. Seguimiento a patógenos presentes en biosólido empleado como enmienda para revegetalizar un talud Follow-up to pathogens present in biosolids used as emendation to reforest a slope

    Directory of Open Access Journals (Sweden)

    Idalia Jacqueline López Sánchez

    2010-07-01

    Full Text Available Con el fin de evaluar la factibilidad del uso del biosólido como enmienda orgánica para el establecimiento de vegetación y el control de procesos erosivos superficiales activos, se seleccionó un corte de carretera ubicado sobrela Variante a Caldas (Antioquia. Para darle amarre y cobertura al suelo, se sembraron dos especies vegetales tipo pasto Brachiaria Decumbens y Kikuyo (Pennisetum clandestinum, utilizando biosólido proveniente de la PTAR San Fernando, mezclado con suelo de la zona. Se evaluó el comportamiento de bioindicadores de riesgo ambiental: coliformes totales, coliformes fecales, Salmonella-Shiguella, en las aguas de escorrentía y en el suelo del talud en el tiempo. Ambas especies se adaptaron bien amarrando el suelo; la cobertura fue total y permanente. Los resultados muestran la factibilidad del uso del biosólido como enmienda. Sin embargo, la permanencia de los parámetros microbiológicos medidos durante el tiempo de evaluación evidencia la necesidad de sanitizar el biosólido antes de usarlo, ya que estos patógenos constituyen un riesgo ambiental.In order to evaluate the feasibility of biosolids use as an organic emendation for reforestation and controlling active superficial erosive processes, a part of the highway -located near to the alternative route to Caldas (Antioquia. With the purpose of preventing erosion, two types of plants Brachiaria Decumbens and kikuyu grass (Pennisetum clandestinum were planted, using biosolids from San Fernando Water Treatment Plant, mixed with soil from the site. The behavior of some environmental risk bioindicators: total coliforms, fecal coliforms, Salmonella-Shiguella, were evaluated, in runoff waters and in the slope soil across the time. Both plant species adapted well to soil; the coverage was complete and permanent. Results show the feasibility of bio-solid as emendation. However, microbiological specifications measured during the evaluation time, showed the need for sanitizing

  14. Evaluación de la curva de crecimiento, cuatro sustratos, dos métodos de esporulación, tres portadores inertes para Trichoderma spp. y su comportamiento frente a ocho fungicidas y cuatro hongos patógenos en laboratorio.

    OpenAIRE

    Erazo Sandoval, Norma Soledad

    2001-01-01

    Como un método alternativo en el combate de enfermedades causadas por patógenos del suelo y de la filósfera, se consideró a Trichoderma spp por sus múltiples cualidades que lo han convertido en el candidato ideal en el manejo de agroecosistemas. Sin embargo, para que sea fácilmente disponible y aceptado, es necesario contar con formulaciones apropiadas, por lo que esta investigación tuvo como objetivo la Determinación de la curva de crecimiento y esporulación de Trichoderma spp.. Se utili...

  15. Optimización de métodos para el estudio del riesgo asociado a la contaminación fecal del agua y alimentos: cuantificación de patógenos y del riesgo de infecciones virales y análisis metagenómico de virus asociados a hepatitis

    OpenAIRE

    Gonzales Gustavson, Eloy Anibal

    2018-01-01

    El agua es esencial para el sostenimiento de la vida en la tierra, por lo tanto, la calidad debe ser controlada para garantizar su uso de forma segura. Los objetivos planteados en esta tesis están orientados a la optimización de métodos para el estudio del riesgo asociado a la contaminación fecal del agua y alimentos. Este trabajo se dividen en tres secciones: La primera parte busca mejorar las herramientas para cuantificar de una manera más precisa los patógenos y el riesgo microbiológico qu...

  16. Optimización de métodos para el estudio del riesgo asociado a la contaminación fecal del agua y alimentos: cuantificación de patógenos y del riesgo de infecciones virales y análisis metagenómico de virus asociados a hepatitis

    OpenAIRE

    Gonzales Gustavson, Eloy Anibal

    2018-01-01

    [spa] El agua es esencial para el sostenimiento de la vida en la tierra, por lo tanto, la calidad debe ser controlada para garantizar su uso de forma segura. Los objetivos planteados en esta tesis están orientados a la optimización de métodos para el estudio del riesgo asociado a la contaminación fecal del agua y alimentos. Este trabajo se dividen en tres secciones: La primera parte busca mejorar las herramientas para cuantificar de una manera más precisa los patógenos y el riesgo microbioló...

  17. Excesso de peso e hipertensão arterial em trabalhadores de empresas beneficiadas pelo Programa de Alimentação do Trabalhador (PAT Overweight and hypertension in workers from companies benefited by the Worker Food Program (WFP

    Directory of Open Access Journals (Sweden)

    Flávio Sarno

    2008-09-01

    Full Text Available OBJETIVO: Avaliar as prevalências de excesso de peso (EP, hipertensão arterial (HA e fatores associados em trabalhadores de empresas beneficiadas pelo Programa de Alimentação do Trabalhador (PAT da cidade de São Paulo. MÉTODOS: Estudo transversal com 1.339 trabalhadores de 30 empresas. A coleta de dados envolveu a aplicação de um questionário com dados de caracterização dos trabalhadores e peso e altura auto-referidos. Foi realizada a aferição da pressão arterial e o estado nutricional foi classificado segundo o Índice de Massa Corporal (IMC. Odds ratios foram estimadas na avaliação dos fatores de risco associados a HA e EP. RESULTADOS: Os trabalhadores apresentaram, em média, 36,4 anos (dp = 10,3 e 9,9 anos de estudo (dp = 2,3, sendo 60% da amostra pertencente ao sexo masculino. Na comparação com homens, mulheres apresentaram valores significativamente menores de idade, pressão arterial sistólica (PAS e diastólica (PAD e IMC e maior escolaridade. As prevalências em homens de EP (25 kg/m2 (56% e de HA (PAS > 140 mmHg e/ou PAD > 90 mmHg ou uso de medicações anti-hipertensivas (38%, foram aproximadamente o dobro da registrada em mulheres (30% e 19%, respectivamente. Idade foi fator de risco para a ocorrência de EP e HA em ambos os sexos, enquanto que a escolaridade foi fator de proteção para EP e HA em mulheres e fator de risco para o desenvolvimento de EP em homens. CONCLUSÃO: Os trabalhadores do sexo masculino constituíram uma população de maior risco para ocorrência de HA e EP e devem ser priorizados nos programas que visam a prevenção dessas doenças. Neste sentido, o PAT pode representar um lugar de destaque nas ações de saúde e nutrição no ambiente de trabalho.OBJECTIVE: Evaluate the prevalences of overweight (OW, hypertension (HY and associated factors in workers from companies benefited by the Worker Food Program (WFP in the city of Sao Paulo. METHODS: Cross sectional study with 1,339 workers from

  18. Korporatīvā sociālā atbildība: patērētāju uztveres un korporāciju komunikācijas analīze starptautiskajos tirgos uz McDonald's un Coca-Cola piemēra.

    OpenAIRE

    Teterins, Pāvels

    2016-01-01

    Korporatīvās sociālās atbildības (KSA) komunikācijas efektivitātes pamats ir pielāgošanās patērētāju prasībām. Pētījuma mērķis bija uz McDonald’s un Coca-Cola sociālo tīklu KSA komunikācijas piemēra, izvērtēt to, vai kompānijas pielāgo KSA komunikāciju patērētāju vērtējumam par atbildīgu uzņēmējdarbību, un piedāvāt optimālu KSA komunikācijas struktūru. Demogrāfisko faktoru ietekme uz Latvijas, Vācijas un Austrālijas KSA vērtējumu praktiski netika novērota. Savukārt, salīdzinot valstis savā st...

  19. Tratamento de sementes com fungicidas relacionado com o controle de patógenos e rendimento de milho Seed treatment with fungicides related to the control of pathogens and corn yield

    Directory of Open Access Journals (Sweden)

    Wilmar Cório da Luz

    1998-12-01

    Full Text Available Os experimentos de milho foram realizados em la boratório; em casa de vegetação e a campo, em Passo Fundo, Rio Grande do Sul, sob presença natural de patógenos, nos anos de 1994 e 1995. Os híbridos usados foram: Braskaib XL 561 em 1994 e Braskaib XL 330 em 1995. Os tratamentos com diferentes concentrações de ingrediente ativo, formulações e doses para 100kg de sementes foram: testemunha; thiram 60 P + iprodione 20 P (150 + 50g; thiram 35 PM + carboxin 35 PM + metalaxyl 35 PM (150 + 700 + 100g, em 1994, e (thiram + carboxin 20 SC (200ml + metalaxyl 35 PM (100g em 1995; thiram 35 PM + carboxin 35 PM (100 + 100g, em 1994 e (thiram + carboxin 20 SC (200ml em 1995; thiram 70 P (150g; imawlil 5 L (150ml; captem 75 P + thiabendawle 10 P (150 + 100g: triadimenol 25 P (160g; captan 75 PM (150g e metalaxyl 35 PM (100g, em 1994 e (50g, em 1995. Os fungicidas foram aplicados misturan do-se cada produto com 250g de sementes dentro de um saco de plástico e agitando-o manualmente por cinco minutos. Todos os tratamentos químicos apresentaram eficiência no controle de Fusarium moniliforme, entretanto metalaxyl e captan em geral foram menos eficientes. Com exceção de metalaxyl, todos os produtos químicos controlaram Cephalosporium acremonium spp. Captan foi menos eficiente que os tratamentos que apresentaram controle em 1994 e apresentou eficiência semelhante a triadime nol e captan + thiabendawle para este fungo, em 1995. Todos os tratamentos, exceto o metalaxyl e o captan (em 1995, no campo aumentaram a emergência das plantas. Thiran e suas misturas também promoveram melhor controle de Penicillium spp. e de Aspergilius spp. e proporcionaram aumentos de rendimento de 13,5% a 14,8% em 1994 e 9,8% a 13,5% em 1995.Experiments were conducted in laboratory, green house and in the field in Passo Fundo, State of Rio Grande do Sul, Braül, under natural presence of pathogens. Com hybrids used were: Braskaib XL 561, and Braskaib XL 330 in 1994 and 1995

  20. Sistemas de cultivo, sucessões de culturas, densidade do solo e sobrevivência de patógenos de solo Cropping systems and previous crops on soil density and survival of soil-borne pathogens

    Directory of Open Access Journals (Sweden)

    Eliane Divina de Toledo-Souza

    2008-08-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito de sistemas de manejo do solo e de cultivos prévios ao plantio do feijoeiro (Phaseolus vulgaris L. sobre a densidade do solo e as populações de Rhizoctonia spp. e de Fusarium spp. Os cultivos prévios incluíram as leguminosas: guandu-anão (Cajanus cajan, estilosantes (Stylosanthes guianensis cv. Mineirão e crotalária (Crotalaria spectabilis; e as gramíneas: milheto (Pennisetum glaucum cv. BN-2, sorgo granífero (Sorghum bicolor cv. BR 304, capim-mombaça (Panicum maximum cv. Mombaça, braquiária (Brachiaria brizantha cv. Marandu e milho (Zea mays consorciado com braquiária. As culturas utilizadas no cultivo prévio foram semeadas nos verões de 2002, 2003 e 2004, e os plantios de feijoeiro, cultivar BRS Valente, foram realizados nos invernos subseqüentes de 2003, 2004 e 2005, com irrigação por pivô central. Os restos culturais dos cultivos eram incorporados ao solo, no plantio convencional, e ficavam à superfície, no plantio direto. De modo geral, as maiores populações de Fusarium spp. e Rhizoctonia spp. e as maiores densidades de solo foram encontradas no solo cultivado em plantio direto. As maiores populações de Rhizoctonia spp. foram observadas em solos mais adensados. As leguminosas geralmente aumentaram populações desses patógenos e devem ser evitadas como culturas prévias ao cultivo do feijoeiro, em ambos os sistemas de cultivo. Plantios prévios de gramíneas, em geral, são supressores das populações de Rhizoctonia spp. e de Fusarium spp. no solo.The objective of this work was to evaluate the effect of cropping systems and crops cultivated previously to common beans (Phaseolus vulgaris L. on soil density and soil populations of Rhizoctonia spp. and Fusarium spp. Previous crops included the following legumes: Cajanus cajan,Stylosanthes guianensis cv. Mineirão and Crotalaria spectabilis; and the following grasses: Pennisetum glaucum (cv. BN-2, millet, Sorghum bicolor

  1. Efeito de lodo de esgoto sobre patógenos habitantes do solo e severidade de oídio da soja Effect of sewage sludge in soil-borne pathogens and powdery mildew severity in soybean

    Directory of Open Access Journals (Sweden)

    Fabio Fernando de Araújo

    2009-09-01

    Full Text Available O lodo de esgoto, atendendo as exigências ambientais, apresenta potencial para disposição em solos agrícolas. Sua incorporação altera as propriedades químicas, físicas e biológicas do solo, pois é rico em macro e micronutrientes e matéria orgânica. Estas alterações podem proporcionar benefícios como aumento da disponibilidade de nutrientes às culturas, indução de supressividade a fitopatógenos habitantes do solo e de resistência às doenças da parte aérea. Por outro lado, pode influenciar negativamente o equilíbrio biológico e químico no solo, devido à presença de contaminantes. O objetivo do trabalho foi avaliar os efeitos da incorporação de lodo de esgoto ao solo sobre a severidade de oídio (Erysiphe diffusa e na supressividade a Rhizoctonia solani e a Macrophomina phaseolina da soja (Glycine max. Para tanto, foram utilizados solos que receberam quatro aplicações (1999 a 2001 sucessivas de lodos de esgoto originários das Estações de Tratamento de Esgoto de Barueri e de Franca, SP, nas concentrações de 0, 1, 2, 4 e 8 vezes (0N a 8N a dose de N recomendada para a cultura do milho. Os estudos com oídio foram realizados em casa de vegetação com inoculação natural em dois cultivos sucessivos de soja. Também foi estudado o efeito de substrato produzido com 0%, 2,5%, 5% 10%, 15% e 20% de lodo de Franca sobre a emergência de plântulas e sobre a severidade de oídio da soja em três e dois ciclos, respectivamente. Nos estudos com R. solani e M. phaseolina, os solos foram artificialmente infestados com os patógenos e posteriormente cultivados com soja por dois ciclos, sendo avaliado o tombamento e a severidade das doenças. A aplicação de lodo de esgoto no solo aumentou a atividade eliciadora de fitoalexinas em soja e a severidade do oídio foi inversamente proporcional às concentrações do lodo, tanto no estudo com o solo de campo, como com o substrato obtido com o lodo de Franca. A emergência das pl

  2. Adapting proofs-as-programs the Curry-Howard protocol

    CERN Document Server

    Poernomo, Iman Hafiz; Crossley, John Newsome

    2007-01-01

    Details developments in the direction of a practical proofs-as-programs paradigm, which constitutes a set of approaches to developing programs from proofs in constructive logic with applications to industrial-scale, complex software engineering problems.

  3. DIGITAL FLOOD INSURANCE RATE MAP DATABASE FOR HOWARD COUNTY, NEBRASKA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  4. On Howard's conjecture in heterogeneous shear flow problem

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    Department of Mathematics, H.P. University, Shimla 171 005, India. ∗. Sidharth Govt. Degree College, Nadaun, Dist. Hamirpur 177 033 ... in proving it in the case of the Garcia-type [3] flows wherein the basic velocity distribution has a point of ...

  5. Blanchett: "Howard Hughes armastas Hepburni lõpuni!" / Triin Thalheim

    Index Scriptorium Estoniae

    Thalheim, Triin, 1982-

    2005-01-01

    Mängufilm "Aviaator - valguses ja varjus" ("The Aviator") : režissöör Martin Scorsese : USA 2004. H. Hughesi ja K. Hepburni elust neid kehastavate näitlejate L. DiCaprio ja C. Blanchetti pilgu läbi

  6. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, HOWARD COUNTY, IOWA, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk Information And supporting data used to develop the risk data. The primary risk;...

  7. Roswell Park Cancer Institute/ Howard University Prostate Cancer Scholars Program

    Science.gov (United States)

    2016-10-01

    Regulation of Expression of Androgen Receptor in ABCG2+ CWR-R1 Prostate Cancer Cells” 4.) Morenike Olu, K Miller, I Gelman, Dept. Cancer Genetics ... rubric for the Directed Readings course sequence. Training in the use of the web conferencing software will be provided by the Project Director at

  8. Howard Robard Hughes (1905-1976) / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2005-01-01

    Ameerika ärimees, kes teostas ennast jõuliselt lennunduses, produtsendina filmikunstis, on prototüübiks Martin Scorsese mängufilmi "Aviaator - valguses ja varjus" ("The Aviator") peategelasele, keda kehastab Leonardo DiCaprio

  9. Experiencias en la vigilancia epidemiológica de agentes patógenos transmitidos por alimentos a través de electroforesis en campo pulsado (PFGE en el Perú Experiences in the epidemiological surveillance of foodborne pathogens by pulsed field gel electrophoresis (PFGE in Peru

    Directory of Open Access Journals (Sweden)

    María Luz Zamudio

    2011-03-01

    Full Text Available Las enfermedades transmitidas por alimentos (ETA y otras enfermedades entéricas infecciosas ocurren a menudo como brotes y son causa de morbilidad y mortalidad en todo el mundo. En el Perú, son un importante problema de salud pública y son causados por una gran variedad de agentes infecciosos. Para la investigación epidemiológica se utiliza una variedad de métodos de tipificación. Una de las herramientas más importantes en la subtipificación molecular de patógenos bacterianos es la técnica de la electroforesis en campo pulsado (PFGE, que es un método altamente resolutivo que permite la discriminación entre diferentes aislamientos bacterianos epidemiológicamente relacionados. El Instituto Nacional de Salud (INS del Perú integra las redes WHO Global Foodborne Infections Network y la Red PulseNet América Latina y Caribe, con quienes comparte los perfiles genéticos de las cepas patógenas aisladas, permitiendo comparar los genotipos de cepas semejantes halladas en diferentes países y reconocer la ocurrencia de brotes epidémicos en la región, fortaleciendo el sistema de vigilancia epidemiológica regional y generando una rápida respuesta conjunta entre países. Se presenta la experiencia de los dos últimos años sobre los avances en la utilización de estas herramientas estratégicas que nos ha permitido caracterizar patrones de genotipo de principales patógenos implicados en ETA a partir de aislamientos recuperados de la red de laboratorios del Perú.Foodborne diseases and other enteric infections often occur as outbreaks and cause morbidity and mortality all over the world. In Perú, they represent a serious public health problem, and are caused by a great variety of infectious agents. For epidemiological research, a wide array of typification methods are used. One of the most important tools for the molecular subtyping of bacterial pathogens is the Pulsed Field Gel Electrophoresis (PFGE, which is a highly precise method that

  10. Plesiomonasshigelloides and Aeromonadaceae family pathogens isolated from marine mammals of Southern and Southeastern Brazilian coast Plesiomonasshigelloides e patógenos da família Aeromonadaceae isolados de mamíferos marinhos da costa sul e sudeste do Brasil

    Directory of Open Access Journals (Sweden)

    Christiane S. Pereira

    2008-12-01

    Full Text Available The aquatic environment is the habitat of many microorganisms, including Plesiomonasshigelloides and Aeromonas species which are pathogenic to human and animals. In the present investigation, we evaluated the occurrence of these pathogens from marine mammals beached or accidentally captured by fishing net in southeastern (RJ and southern (RS coastal Brazilian regions. A total of 198 swabs from 27 specimens of marine mammals, including 11 different species, were collected by DEENSP and GEMARS-CECLIMAR/UFRGS Institutes and sent to LRNCEB/IOC/FIOCRUZ. The samples were enriched in Alkaline Peptone Water (APW added with 1% of sodium chloride (NaCl, APW plus 3% NaCl and incubated at 37ºC for 18-24 hours. Following, samples were streaked onto Pseudomonas-Aeromonas Selective Agar Base (GSP Agar and suspected colonies were biochemically characterized. The results revealed 114 strains, including ten Aeromonas species and P.shigelloides. The main pathogens isolated were A.veronii biogroup veronii (19.3%, A. caviae (12.3%, A. hydrophila (9.6% and P.shigelloides (7%. The pathogens were isolated in both coastal and offshore marine mammals. These data point the importance of epidemiological surveillance and microbiological monitoring and reinforce the need to implement environmental protection programs, especially related to endangered cetacean species.O ambiente aquático é o habitat de vários microrganismos, incluindo Plesiomonasshigelloides e espécies de Aeromonas, os quais são patogênicos para o homem e os animais. Na presente investigação, foi avaliada a ocorrência destes patógenos a partir de swabs coletados de mamíferos marinhos encalhados ou capturados acidentalmente em redes de pesca nas regiões costeiras do sudeste (RJ e sul (RS do Brasil. O total de 198 swabs de 27 espécimes de mamíferos marinhos, incluindo 11 espécies distintas, foi coletado por profissionais dos institutos DEENSP, GEMARS-CECLIMAR/UFRGS e enviado ao LRNCEB

  11. Black bass (Micropterus salmoides, Lacepède 1802 fingerlings performance and survival, submitted to the alimentary conditioning, using different proteics pâtés / Desempenho e sobrevivência de alevinos de black bass (Micropterus salmoides, Lacepède 1802, submetidos ao condicionamento alimentar, utilizando diferentes patês protéicos

    Directory of Open Access Journals (Sweden)

    Arcangelo Augusto Signor

    2008-08-01

    Full Text Available The aim of this study was to evaluate the use of artificial rations with different proteics pâtés incorporated in the black bass (Micropterus salmoides fingerlings diet. 320 fingerlings, with initial average weight of 0,57±0,1g and lenght of 3,61±0,21cm, respectively were used. The fish were distributed in an entirely casualized delineation in 32 polypropylene boxes of 310 liters, with 4 treatments and 8 repetitions. One reference ration (RR with 38% PB as diet base was used, being added to each treatment proteics pâtés (PP, composites of bovine heart (CB, eviscerate sardine (SE, Chilean fish flour (FP and tilapia fillet (FT. During the alimentary training good acceptance of the artificial diets was observed, with better performance results for the treatments with FP and FT.O objetivo deste trabalho foi avaliar a utilização de rações artificiais com diferentes patês protéicos incorporados na dieta de alevinos de black bass (Micropterus salmoides. Foram utilizados 320 alevinos, com peso e comprimento inicial médio de 0,57±0,1g e 3,61±0,21cm, respectivamente. Os peixes foram distribuídos em um delineamento inteiramente casualizado em 32 caixas de polipropileno de 310 litros, com 4 tratamentos e 8 repetições. Utilizou-se uma ração referência (RR com 38% PB como base da dieta, sendo adicionada patês protéicos (PP referente a cada tratamento, compostos por coração bovino (CB, sardinha eviscerada (SE, farinha de peixe chilena (FP e filé de tilápia (FT. Durante o treinamento alimentar foi observado boa aceitação as dietas artificiais, com melhores resultados de desempenho para os tratamentos com FP e FT.

  12. Navy Force Structure and Shipbuilding Plans: Background and Issues for Congress

    Science.gov (United States)

    2014-08-01

    missions described in the DSG [Defense Strategic Guidance]. There are numerous ways to adjust Navy’s portfolio of programs to meet the BCA revised...balance of force structure (current and future), modernization and personnel within our portfolio , continued compliance with the BCA revised...Catherine Dale and Pat Towell. See also CRS Report R42448, Pivot to the Pacific? The Obama Administration’s “ Rebalancing ” Toward Asia, coordinated by

  13. Artéria torácica interna enxertada: patência e estado funcional em repouso e após dobutamina Internal thoracic artery graft (ITAG: patency and functional status at rest and during dobutamine-stress echocardiography

    Directory of Open Access Journals (Sweden)

    José Sebastião de Abreu

    2008-01-01

    Full Text Available FUNDAMENTO: A artéria torácica interna enxertada (ATIE patente usualmente tem fração diastólica (FD> 50% do fluxo. O estado funcional pode ser avaliado pelo índice de reserva coronariano (IRC. OBJETIVO: Avaliar, pela ecocardiografia e pelo Doppler em nível supraclavicular, a patência e o estado funcional da ATIE. MÉTODOS: Foram coletados prospectivamente e analisados os dados de 66 pacientes submetidos a ecocardiograma sob estresse com dobutamina (EED. O grupo I (GI ocorreu com 49 ATIE sem estenose. No grupo II (GII (10 ATIE havia estenose significativa (> 50% e 50%, ocorreu em 49 ATIE (GI=40, GII=8 e GIII=1 no repouso e em 61 ATIE (GI=49, GII=10 e GIII=2 durante EED. Sensibilidade, especificidade, valor preditivo positivo (VPP, valor preditivo negativo (VPN e acurácia foram, respectivamente, em repouso, 81%, 86% ,98%, 35 % e 82%; e no EED, 100%, 71%, 97%, 100% e 97%. As ATIE com FD>50% em repouso estavam patentes e as com FD1,8, isso ocorreu em 42 ATIE (39 do GI, 2 do GII e 1 GIII, verificando-se sensibilidade = 79%; especificidade = 85,7%; VPP = 94%; VPN = 59%; e acurácia = 80,9%. O IRC no GI foi maior (p=0,02 que em GII e GIII. CONCLUSÃO: Em nosso estudo, a avaliação não-invasiva da ATIE foi efetiva para verificar patência e estado funcional.BACKGROUND: The patent internal thoracic artery graft (ITAG usually has a diastolic fraction (DF > 50% of the flow. The functional assessment can be evaluated by the coronary reserve index (CRI. OBJECTIVE: The objective was to evaluate the patency and functional status of the ITAG through echocardiography and Doppler. METHODS: Data from sixty-six patients who underwent dobutamine-stress echocardiography (DSE were prospectively collected and analyzed. Group I (GI had 49 ITAG without stenosis, Group II (GII, 10 ITAG with significant stenosis (> 50% and 50%, it was observed in 49 ITAG (GI= 40, GII= 8 and GIII= 1 at rest and in 61 ITAG (GI=49, GII=10 and GIII=2 during DSE. The sensitivity

  14. Climate change and waterborne pathogens: the El Niño phenomenon and its impact on health Cambio climático y patógenos en el agua: el fenómeno de El Niño y su impacto en la salud

    Directory of Open Access Journals (Sweden)

    Jaime Martínez Urtaza

    2011-12-01

    principales patógenos humanos del género Vibrio: V. cholerae y V. parahaemolyticus. Durante los últimos años, se ha estudiado la interacción de los océanos y las anomalías climáticas en la dinámica de las enfermedades causadas por estos patógenos, utilizando la información oceanográfica aportada por los satélites. Estudios realizados en Perú, empleando estas nuevas herramientas han permitido asociar la expansión epidémica de las infecciones de V. cholera y V. parahaemolyticus en Suramérica con la llegada y propagación de las aguas de El Niño. Estudios posteriores, utilizando datos de detección remota por satélite para analizar la dinámica de los brotes de infección por V. parahaemolyticus en Estados Unidos, España y Chile, han permitido establecer que la aparición de las infecciones en estas regiones fue igualmente concurrente con la presencia de anomalías oceánicas. De esta forma, se ha identificado a los movimientos de aguas oceánicas como un motor potencial de dispersión de las infecciones de Vibrio a escala global, abriendo nuevas vías para explorar y predecir los nuevos brotes epidémicos de estas enfermedades.

  15. 'All I Can Remember Were Tablets': Pat's Story.

    Science.gov (United States)

    McClimens, Alex

    2002-01-01

    This article discusses the use of personal narrative in social science research and in helping individuals with learning difficulties renegotiate their sense of identity. One woman's story of her life is used to illustrate the corrosive effects of institutionalization in identity formation. (Contains references.) (DB)

  16. Nutritional support of the hospitalized patIent

    African Journals Online (AJOL)

    1983-04-16

    Apr 16, 1983 ... one ofthe earliest attempts known was that of Sir Christopher. \\\\hen, to whom 50 much ofthe architectural elegance of London can be attributed, being ..... O'Keefe SJO, Abraham R, EI-Zayadi A, Marshall W, O"'is M, Williams R. Increased plasma tyrosine concentrations in patients with cirrhosis and fulmi-.

  17. Nutritional support of the hospitalized patIent

    African Journals Online (AJOL)

    1983-04-16

    Apr 16, 1983 ... ments, as well as the attempts ofothers to transfuse animal blood into human ..... incorporation ofan infusion pump (e.g. IVac and IMed models). The choice of pump ... IMed Model 922), while with the 3-litre container peristaltic.

  18. and vein factor patIents Comparison between umbilical artery ...

    African Journals Online (AJOL)

    tase (ATPase) of normal blood vessels, red cells and white cells.7. Inhibition of sodium-potassium ATPase and the sodium-potassium pump has also been reported at tissue and cellular levels in patients with low-renin hypertension.7. ,8. Various tissues have been reported to contain DLIF, e.g. extracts of mammalian brain,9 ...

  19. Pop-up Archival Transmitting (PAT) fish tag data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The cooperative tagging center (CTC) began deploying electronic tags in 2002. To date over 300 tags have been deployed. The following species have been monitored:...

  20. Jazz, guitar, and neurosurgery: the Pat Martino case report.

    Science.gov (United States)

    Galarza, Marcelo; Isaac, Claire; Pellicer, Olga; Mayes, Andrew; Broks, Paul; Montaldi, Daniela; Denby, Christine; Simeone, Frederick

    2014-01-01

    We present the case of a professional jazz guitarist with temporal lobe epilepsy secondary to an arteriovenous cerebral malformation. The patient underwent a left temporal lobectomy in 1980. After surgery, he presented with severe retrograde amnesia and complete loss of musical interest and capabilities. The patient's musical abilities recovered over time, and he regained his previous virtuoso status. In 2007, his medical history, neuropsychologic functions, and structural magnetic resonance imaging study were examined and revealed a remarkable degree of recovery of memory and musical abilities in the context of extensive temporal lobe resection. The neuropsychologic findings and neuroanatomic features of the magnetic resonance imaging study were analyzed to try to understand the high degree of recovery of both long-term memory and musical processing abilities in this musician. This case reveals the possibility of an unusual degree of cerebral plasticity and reorganization. Additionally, it emphasizes the question of musical virtuosity. This report shows that the musical capabilities of professional musicians, in specific cases, can completely recover even when much of the left temporal lobe has been removed. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Study of domain structure in segmented polyether polyurethaneureas by PAT

    International Nuclear Information System (INIS)

    Yin Chuanyuan; Xu Weizheng; Gu Qingchao

    1990-01-01

    The domain structure of segmented polyether polyurethaneureas is investigated by means of positron annihilation technique, small angle X-ray scattering and differential scanning calorimetry. The experimental results show that the decrease of domain volume and free volume results from the increase of hard segment contents, and that the increase of domain volume and free volume results from the increase of molecular weight of soft segments

  2. First report of Lasiodiplodia theobromae (Pat.) Griffon & Maubl ...

    African Journals Online (AJOL)

    SARAH

    2014-07-31

    Jul 31, 2014 ... *1School of Crop and Seed Production and Management (EGPVS), ... 2International Institute of Tropical Agriculture, 08 BP 0932, Cotonou, Rep. ... Objective: Jatropha curcas L. is an important biofuel crop grown worldwide.

  3. Psychophysical estimation of acid intensity and determination of sweet-acid interaction in a fish paste containing glycerol Estimação psicofísica da intensidade ácida e determinação da interação ácido-doce em patê de pescado contendo glicerol

    Directory of Open Access Journals (Sweden)

    Gabriela Leonor Sánchez Pascua

    2010-05-01

    Full Text Available In a fish paste made with cooked Brazilian flathead (Percophis brasiliensis, glycerol (17%, sodium chloride (1.5% and potassium sorbate (0.1% the following acid percentages: 0.2; 0.4; 0.6; 0.8, 1 and 1.5% w/w were incorporated to determine the relationship between added acetic acid and the sensorially perceived intensity, and the effects of the combination of sweet-acid tastes. Tests for paired comparison, ranking and structured verbal scales for sweet and acid attributes and psychophysical test were carried out. There was a perceptible difference among samples for differences of 0.4 units of acid concentration. Samples indicated as sweeter by 89.47% of the judges were those containing a lesser acid concentration. A reduction in glycerol sweetness when increasing acid levels was observed. Acetic acid reduced the sweetness of glycerol and inversely glycerol reduced the acidity of acetic acid. The data obtained with the magnitude estimation test agree with Steven's law.Foram incorporados glicerol (17%, cloreto de sódio (1,5% e sorbato de potássio (0.1% nas seguintes porcentagens de ácido: 0,2; 0,4; 0,6; 0,8; 1 e 1,5% p/p, em um patê elaborado a partir de congro-real (Percophis brasiliensis cozido, com o intuito de determinar a relação entre o ácido acético adicionado e a intensidade sensorialmente percebida, assim como o efeito da combinação dos gostos doce e ácido. Foram realizados testes de comparação pareada, de classificação e também estruturada uma escala verbal para os atributos ácido e doce, e testes psicofísicos. Foi percebida diferença entre as amostras com diferença de 0,4 unidades de concentração de ácido. As amostras indicadas como as mais doces por 89,47% dos julgadores foram as que continham menor concentração de ácido. Foi observada a redução da doçura do glicerol quando aumentaram os níveis de ácido. O ácido acético reduziu a doçura do glicerol e, inversamente, o glicerol reduziu a acidez do

  4. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, DALE COUNTY, ALABAMA AND INCORPORATED AREAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  5. The horn, kink and step, dale: from few GeV to few TeV

    Science.gov (United States)

    Rustamov, Anar

    2012-12-01

    Rich experimental data have been collected in heavy-ion collisions at high energies to study the properties of strongly interacting matter. As the theory of strong interactions, QCD, predicts asymptotic freedom, the created matter at sufficiently high temperature and density will be dominated by a state of quasi-free quarks and gluons referred to as the Quark-Qluon Plasma (QGP). Experimental signals for the onset of the QGP creation (the onset of the deconfinement) have been predicted within the statistical model for the early stage of nucleus-nucleus collisions. In this model the existence of two different phases is assumed: confined mater and the QGP, as well as a first order phase transition between them. Until recently, these predictions were confirmed only by the NA49 experiment at the CERN SPS. In this report recent results from STAR at RHIC/BNL and from ALICE at LHC/CERN, related to the onset of deconfinement, will be compared to published results from NA49.

  6. Conversations with Four Highly Productive Educational Psychologists: Patricia Alexander, Richard Mayer, Dale Schunk, and Barry Zimmerman

    Science.gov (United States)

    Patterson-Hazley, Melissa; Kiewra, Kenneth A.

    2013-01-01

    This article seeks to answer the questions: Who are the most productive and influential educational psychologists? What factors characterize these educational psychologists? And, what advice might they pass along to budding scholars? To determine the top educational psychologists, we surveyed the membership of Division 15 (Educational Psychology)…

  7. Une histoire des mathématiques routes et dédales

    CERN Document Server

    Dahan-Dalmedico, Amy

    1986-01-01

    L'histoire des mathématiques est celle des conjectures, des hésitations, des impasses, des modèles concurrents, des intuitions fulgurantes, des synthèses théoriques... La naissance et le développement de l'activité mathématique sont ici replacés dans leur contexte historique et leur environnement culturel, économique et institutionnel. Le cadre est ainsi fixé pour l'étude précise de différents thèmes : équations, espace, limite, fonctions, lois, opérations ; notions fondamentales auxquelles tout élève, étudiant, enseignant est confronté. Les mathématiques ne se présentent pas, ici, comme un corps figé d'axiomes, théorèmes, lemmes et corollaires ; elles tissent une toile en devenir qui suscite bien des curiosités.

  8. Daling transvetzuren, maar niet in alle grootverbruikproducten: vetzuursamenstelling van spijsvetten, koek en snacks.

    NARCIS (Netherlands)

    Hulshof, P.J.M.; Zock, P.L.; Kosmeijer-Schuil, J.G.; Bovenkamp, van de P.; Katan, M.B.

    1998-01-01

    Deze vetzuren hebben een ongunstige invloed op het lipoproteineprofiel in het bloed. In een tabel is de vetzuursamenstelling van geselecteerde koek en snacks weergegeven. Tegenwoordig bevatten de margarines, bak- en braadvetten aanzienlijk minder verzadigd vet

  9. Myxomatosis: some observations on breeding the European rabbit flea Spilopsyllus cuniculi (Dale) in an animal house

    Science.gov (United States)

    Sobey, W. R.; Menzies, W.; Conolly, Dorothy

    1974-01-01

    Rabbit fleas for use in Myxomatosis investigations have been successfully bred on rabbits in an animal house. The timing of emergence appeared to be governed by a biological timing control interacting with different forms of disturbance. Yield was found to be related to litter size, the time the doe and her kittens were removed from the nest, the number of fleas put onto a doe before littering and the mean ambient temperature to which the doe was exposed in the week pre-partum. The survival rate of fleas in storage was affected by temperature, the degree of crowding, moisture content of the containers, whether fleas were fed or unfed and the source of fleas in terms of emergence times. PMID:4526409

  10. Techno 2000, Modellering van de daling van eenheidskosten van technologieen in de tijd

    NARCIS (Netherlands)

    Honig E; Hanemaaijer, A; Engelen R; Dekkers A; Thomas R; LAE

    2000-01-01

    When making projections in Environmental Outlooks, in estimating the future environmental costs RIVM considers these costs as being constant through time. However, in reality these costs are not constant, but they decrease as a result of scale- and learning effects. This report presents a method to

  11. Techno 2000, Modellering van de daling van eenheidskosten van technologieen in de tijd

    NARCIS (Netherlands)

    Honig E; Hanemaaijer A; Engelen R; Dekkers A; Thomas R; LAE

    2000-01-01

    When making projections in Environmental Outlooks, in estimating the future environmental costs RIVM considers these costs as being constant through time. However, in reality these costs are not constant, but they decrease as a result of scale- and learning effects. This report presents a method

  12. Blood and Gore, Fens and Fears: "Beowulf" Battles the Dale-Chall Monster.

    Science.gov (United States)

    Wagner, Betty Jane

    Unfortunately, textbooks of the elementary and junior high school levels receive very little of the honest, critical evaluation which is given trade books in children's literature. One vivid example of this fact was seen in the recent arduous but successful attempt to include "Beowul" in a fourth-grade literature text which was being…

  13. De daling van de lichaamstemperatuur tijdens de triatlon [The decrease in body temperature during the triathlon

    NARCIS (Netherlands)

    Daanen, H.A.M.

    1993-01-01

    Op grond van literatuurgegevens en eigen onderzoek wordt aannemelijk gemaakt dat niet tijdens het zwemonderdeel van de triatlon, maar tijdens het fietsonderdeel de laagste temperaturen in de kern van het lichaam voorkomen. Naast de voortgezette fysische koeling van de kern, wordt door het fietsen de

  14. Een onderzoek over de waarde van de Schultz-Dale techniek in de immuno-pathologie

    NARCIS (Netherlands)

    Jansz, Anton

    1960-01-01

    Dit proefschrift geeft in hoofdstuk I een overzicht over problemen in de immuno-pathologie. waarbij vooral aandacht wordt geschonken aan de auto-immunologische ziekteprocessen. Een beter inzicht hierin kan verkregen worden door dierexperimenteel en door serologisch onderzoek. Het laatste vooral

  15. Revisión: Spongospora subterranea f.sp. subterranea y su Virus Asociado Potato mop-top virus (PMTV, Dos Patógenos Reemergentes en los Cultivos de Papa de Colombia Review: Spongospora subterranea f.sp. subterranea and its Associated Virus Potato mop-top virus (PMTV, Two Re-emerging Pathogens of Potato Crops in Colombia

    Directory of Open Access Journals (Sweden)

    Inés Osorio Giraldo

    2012-06-01

    Full Text Available Resumen. El cultivo de papa es uno de los renglones agrícolas de mayor importancia en Colombia; se extiende a 128.701 ha y genera una producción anual de 2,3 millones de t año-1. Desde el punto vista fitosanitario, la papa se ve afectada por diversos problemas, destacándose en los últimos años la reemergencia de la sarna polvosa causada por el protozoario del suelo Spongospora subterranea f.sp. subterranea (Sss. El efecto de esta enfermedad se refleja en el deterioro de la calidad del tubérculo y en la reducción de la producción, al afectar el sistema radicular y los tubérculos. Además, Sss es el vector natural del Potato mop-top virus (PMTV, uno de los virus prevalentes en la región Andina y que presenta carácter cuarentenario en diferentes países del mundo. En esta revisión se presenta el estado de conocimiento que se tiene en el mundo sobre éstos dos fitopatógenos, haciendo énfasis en los principales hallazgos que se han realizado en Colombia sobre sus niveles de variación genética, efecto sobre la producción y métodos de detección. Se espera que la información presentada, llame la atención a los organismos estatales de sanidad vegetal, gremios de productores, asistentes técnicos y agricultores, sobre la importancia creciente que presentan dichos patógenos en los sistemas de producción de papa. Además, que sirva de base para el diseño de herramientas de diagnóstico que apoyen los esquemas de certificación de tubérculo semilla y los programas de mejoramiento genético de papa que se adelantan en Colombia.Abstract. Potato is one of the most important crops in Colombia, comprising 128.701 ha and a total production of 2.3 million t year-1. There are several phytopathological problems affecting this crop, however, the soil protozoan Spongospora subterranea f.sp. subterranea (Sss, the causal agent of powdery scab, stands out due to its recent reemergence. Powdery scab can seriously deteriorate tuber quality and

  16. DIGITAL FLOOD INSURANCE RATE MAP BaseMap, HOWARD COUNTY, TEXAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  17. 75 FR 43138 - Ochoco National Forest, Lookout Mountain Ranger District; Oregon; Howard Elliot Johnson Fuels and...

    Science.gov (United States)

    2010-07-23

    ... Analysis. Generally speaking, the Watershed Analysis determined that vegetation condition in the... scoping process. The Ochoco National Forest will give notice of the full environmental analysis and.... DATES: Comments concerning the scope of the analysis must be received by August 23, 2010. The draft...

  18. DCS Hydrology Submission for Big Slough located in Howard County, Nebraska

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  19. 75 FR 18826 - Mr. Howard Rosenfeld; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-04-13

    ... to; (4) an existing 25-foot-high, 22-foot-square stone-masonry building to house; (5) a new turbine generator unit, with a maximum hydraulic capacity of 5 cubic feet per second (cfs) and total installed...

  20. Lower Bounds for Howard's Algorithm for Finding Minimum Mean-Cost Cycles

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Zwick, Uri

    2010-01-01

    Mean-Cost cycles (MMCC). Experimental studies suggest that Howard’s algorithm works extremely well in this context. The theoretical complexity of Howard’s algorithm for finding MMCCs is a mystery. No polynomial time bound is known on its running time. Prior to this work, there were only linear lower...

  1. 2004 Anne Arundel, Charles, Howard & St. Mary's Counties LiDAR Mapping

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Light Detection and Ranging (LIDAR) is a method of locating objects on the ground using aerial-borne equipment. It is similar to RADAR or SONAR in that the two-way...

  2. De acute daling van leptine na een energiearme voeding : een biologische indicator voor de gevoeligheid voor het ontwikkelen van overgewicht?

    NARCIS (Netherlands)

    Mars, M.

    2004-01-01

    The last decades the prevalence of obesity has been increasing. However, large inter-individual differences in weight gain are observed. Poor energy intake regulation is one of the possible mechanisms behind a large susceptibility to weight gain. The hormone leptin is suggested to have a key-role in

  3. Dale Herspring, The Kremlin and the High Command. Presidential Impact on the Russian Military from Gorbachev to Putin

    Directory of Open Access Journals (Sweden)

    Isabelle Facon

    2009-03-01

    Full Text Available In late 2008 Russian civil-military relations underwent a difficult period. Following the war in Georgia, the political leadership initiated new efforts to reform the military. Anatoly Serdiukov, the Russian Defense Minister, was appointed in 2007 by former president Vladimir Putin with a clear mandate to control military spending and eliminate many redundant senior officer posts. Concurrently, the new Russian president, Dmitri Medvedev, has affirmed his predecessor’s position that the condit...

  4. Petrography and geochemistry of the Dales Gorge banded iron formation: Paragenetic sequence, source and implications for palaeo-ocean chemistry

    DEFF Research Database (Denmark)

    Pecoits, E.; Gingras, M. K.; Barley, M. E.

    2009-01-01

    provenance. Nonetheless, when all the lithologies (i.e., source rocks, S and BIF macrobands) are evaluated together, continuous geochemical trends can be observed. This suggests that at least part of the precursor material of BIF macrobands was sourced from the same material that gave origin to the S...

  5. Compliance Monitoring of Juvenile Yearling Chinook Salmon and Steelhead Survival and Passage at The Dales Dam, Spring 2011

    Energy Technology Data Exchange (ETDEWEB)

    Skalski, John R.; Townsend, Richard L.; Seaburg, Adam; Johnson, Gary E.; Ploskey, Gene R.; Carlson, Thomas J.

    2012-02-01

    The study estimated dam passage survival at The Dalles Dam as stipulated by the 2008 Federal Columbia River Power System (FCRPS) Biological Opinion (BiOp) and provided additional performance measures as stipulated in the Columbia Basin Fish Accords. This summary report focuses on spring run stocks, yearling Chinook salmon and steelhead.

  6. Petition to Object to the Eastern Kentucky Power Coop. William C. Dale Power Station, Ford, Kentucky, Title V Operating Permit

    Science.gov (United States)

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  7. A Robust Process Analytical Technology (PAT) System Design for Crystallization Processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan; Gernaey, Krist

    2013-01-01

    A generic computer-aided framework for systematic design of a process monitoring and control system for crystallization processes has been developed to study various aspects of crystallization operations. The design framework contains a generic multidimensional modelling framework, a tool for gen...

  8. A systematic framework for design of process monitoring and control (PAT) systems for crystallization processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan; Gernaey, Krist

    2013-01-01

    A generic computer-aided framework for systematic design of a process monitoring and control system for crystallization processes has been developed to study various aspects of crystallization operations.The systematic design framework contains a generic crystallizer modelling toolbox, a tool for...

  9. Staphylococcus cohnii spp urealyticus: relato de caso de um patógeno incomum

    OpenAIRE

    d'Azevedo,Pedro Alves; Antunes,Ana Lúcia Sousa; Martino,Marinês Dalla Valle; Pignatari,Antonio Carlos Campos

    2008-01-01

    Staphylococcus coagulase negativos tem surgido como importantes agentes em infecções de pacientes hospitalizados. Neste estudo, relatamos o caso de bacteremia associada a cateter venoso central devido a Staphylococcus cohnii spp urealyticus isolado em hemocultura de um paciente do sexo masculino, 53 anos, internado em hospital geral da cidade de São Paulo. Discutimos nesse relato a dificuldade em identificar rotineiramente esse microrganismo no Laboratório de Microbiologia Clínica. Staphyloco...

  10. Structural modelling of ASR-affected concrete : The approach developed in the PAT-ASR project

    NARCIS (Netherlands)

    Esposito, R.; Hendriks, M.A.N.

    2013-01-01

    The Alkali-Silica Reaction is a harmful reaction which can compromise the integrity and capacity of concrete structures. Due to its nature, a multiscale material model has been chosen to perform structural analyses. The model aims to couple the chemical and mechanical effects in order to

  11. RIMAP demonstration project. Pat. 1: Risk based life management of piping system in power plant Heilbronn

    International Nuclear Information System (INIS)

    Bareiss, J.; Puck, P.; Matschecko, B.; Jovanovic, A.; Balos, D.; Perunicic

    2003-01-01

    In the framework of EU project RIMAP [1] a new European Guideline for optimized risk based maintenance and inspection planning of industrial plants (RBLM - Risk Based Life Management) is being developed. The RIMAP project consists of the three clustered projects: development (RTD), demonstration (DEMO) and thematic network (TN). Current work and future, planned work in RIMAP demonstration project on applications of the RIMAP methodology in power plants are presented briefly in the first part of the paper. Also presented in the paper are the results of a preliminary analysis of piping system in power plant Heilbronn using the concept of risk-based monitoring as part of overall concept of risk-based life management. Shortly the following issues are discussed in the paper: identification of critical components, application of a multilevel risk analysis (..from ''screening'' to ''detailed analysis''), determination of PoF - Probability of Failure, determination of COF - Consequence of Failure and optimation of inspection and maintenance plan. (orig.)

  12. Microorganismos patógenos en Jatropha curcas Linnaeus. Estrategias potenciales para su manejo

    Directory of Open Access Journals (Sweden)

    O Alonso

    Full Text Available Jatropha curcas Linnaeus (piñón botija, considerada la gran promesa verde para el biodiesel, es una planta de la que existen considerables incógnitas en el ámbito científico desde el punto de vista agronómico, sobre todo en lo referente a los microorganismos causantes de enfermedades, entre las que sobresale la conocida como damping off (estrangulamiento de las plántulas que es provocada por varias especies de hongos. Por ello, el objetivo de este artículo es compilar la mayor cantidad de información sobre los principales microorganismos fitopatógenos que afectan a J. curcas, así como las posibles estrategias para su manejo, con el fin de obtener rendimientos eficientes y rentables de este cultivo energético en Cuba. Se encontraron 48 agentes causales de enfermedades; los más representativos fueron los hongos, entre los que predominan los que producen la roya y el mildiu polvoso, fundamentalmente. En cuanto al manejo fitosanitario, se citan las medidas culturales preventivas y las químicas, como curativas. De ahí que en Cuba, al igual que en otros países donde se cultiva el piñón botija, sea imprescindible conocer los fitopatógenos que pueden reducir los rendimientos de dicha planta, para después implementar un sistema de manejo fitosanitario que contribuya a evitar pérdidas considerables en la producción de biodiesel como producto final.

  13. Pump as Turbine (PAT Design in Water Distribution Network by System Effectiveness

    Directory of Open Access Journals (Sweden)

    Oreste Fecarotta

    2013-08-01

    Full Text Available Water distribution networks face several problems related to leakages, where the pressure control strategy is a common practice for water loss management. Small-scale hydropower schemes, where pumps as turbines replace pressure reducing valves, can be considered an interesting technical solution, which ensures both economic convenience and system flexibility. Due to the water networks’ variable operating conditions, a new methodology to model the effectiveness of pumps as turbines was developed based on the efficiency and the mechanical reliability of the hydropower device and the flexibility of the plant. System effectiveness is proposed as the objective function in the optimization procedure and applied to a real system, enabling one to emphasize that the hydraulic regulation mode of the plant is better than the electric regulation mode for American Petroleum Industry (API manufacturing standards of pumps.

  14. PAT portable appliance testing : in-service inspection and testing of electrical equipment

    CERN Document Server

    Scaddan, Brian

    2015-01-01

    The Electricity at Work Regulations 1989 requires any electrical system to be constructed, maintained and used in such a manner as to prevent danger. This means that inspection and testing of systems, including portable appliances, is needed in order to determine if maintenance is required. This book explains in clear language what needs to be done and includes expert advice on legislation as well as actual testing. The book contains an appendix providing the electrical fundamentals needed by non-specialists and also has sample questions (with answers) for the C&G 2377 exam. It is also an ideal revision guide for the non-specialist, such as maintenance staff and caretakers who carry out these tasks part-time, alongside their many other duties.

  15. Study of Bi-2212 phase doped Sn(Pb) by means of pat

    International Nuclear Information System (INIS)

    Ma Qingzhu; Huang Xiaoqian; Xiong Xiaotao

    1997-01-01

    Investigation on the effect of Sn/Pb-doped Bi-2212 superconductors has been carried out by the simultaneous measurements of the spectra of positron annihilation lifetime and positron Doppler broadening, together with X-ray diffraction. The results of samples with different doping level show the occupation of Sn atoms on Bi sites. At weak doping level, Sn doping results in a enhancement of cooperation between layers and increment of superconducting transition temperature. At the strong doping level, Sn atoms occupy the sites of Cu-O layers, and at the same time, the other nonsuperconducting phases appear, which results in a decline of the superconducting transition temperature

  16. [Development of a paté formulation basis on rainbow trout discards].

    Science.gov (United States)

    Villarroel, Mario; Hazbun, Julia; Morales, Pamela

    2010-06-01

    An optimized formulation of pate was developed using rainbow trout discard with the employment ofTaguchi methodology, taking into account that the health-promoting benefits of this resource makes it a viable alternative as a functional foods to help consumers to get a healthy lifestyle. The optimization process utilizing Taguchi methodology was carried out in two phases. First, an orthogonal array L(8)2(7) with seven independent variables was chosen to select the control factors with a significant effect on the sensory quality (SQ). As a result, the following independent variables were selected: merkén pepper, sodium chloride, vegetal lard and margarine. In the second stage the L(9)3(4) orthogonal array was used. Data were analysed using differences between average values of factors according working levels, and also ANOVA, summing up that merken pepper, sodium chloride and margarine showed a significant effect (p > 0.05) on the SQ. Best combination turned to be: merkén 0.7%, sodium chloride 1.3%, vegetal lard 5.2% and margarine 5.2%. Among the chemical characteristics highlighted protein 13.8%, lipid 10.21%, caloric density 175 Kcal/100 g and cholesterol 46 mg/100 g. Shelf life study during a period of time of 6 weeks at 5 degrees C expressed as mesophyl aerobic count (MAC) and peroxide index were 1.6E+0.4 ufc/g and 8.44 meg O2/Kg respectively, both characteristics lower than the maximum limits allowed for chilean regulations. Concerning to the acceptability of the optimized product the hedonic test showed 91% approval and also 87% of consumers would be well disposed to buy this product.

  17. Señales entre hongos patógenos y plantas hospederas resistentes

    Directory of Open Access Journals (Sweden)

    G. Camarena Gutiérrez

    2001-01-01

    Full Text Available Los hongos parásitos obligados obtienen sus nutrimentos de células vivas. Durante su ciclo de vida, se forman tres tipos de estructuras intracelulares (hifa de invasión, haustorio M y haustorio D y cada uno puede afectar de manera diferente la membrana de la célula huésped que le rodea, también cómo afectar otros componentes celulares. Cada estructura intracelular también previene que se disparen defensas no específicas de la planta por la actividad del hongo, posiblemente interfiriendo el sistema de señales más que la expresión de defensa.

  18. Ganoboninketals A-C, Antiplasmodial 3,4-seco-27-Norlanostane Triterpenes from Ganoderma boninense Pat.

    Science.gov (United States)

    Ma, Ke; Ren, Jinwei; Han, Junjie; Bao, Li; Li, Li; Yao, Yijian; Sun, Chen; Zhou, Bing; Liu, Hongwei

    2014-08-22

    Three new nortriterpenes, ganoboninketals A-C (1-3), featuring rearranged 3,4-seco-27-norlanostane skeletons and highly complex polycyclic systems were isolated from the medicinal mushroom Ganoderma boninense. The structures of the new metabolites were established by spectroscopic methods. The absolute configurations in 1-3 were assigned by electronic circular dichroism (ECD) calculations. Compounds 1-3 showed antiplasmodial activity against Plasmodium falciparum with IC50 values of 4.0, 7.9, and 1.7 μM, respectively. Compounds 1 and 3 also displayed weak cytotoxicity against A549 cell line with IC50 values of 47.6 and 35.8 μM, respectively. Compound 2 showed weak cytotoxicity toward HeLa cell line with an IC50 value of 65.5 μM. Compounds 1-3 also presented NO inhibitory activity in the LPS-induced macrophages with IC50 values of 98.3, 24.3, and 60.9 μM, respectively.

  19. Hongos patógenos de insectos en Argentina (Zygomycetes: Entomophthorales

    Directory of Open Access Journals (Sweden)

    C.C López Lastra

    2006-06-01

    Full Text Available Se informa de tres especies de hongos Entomophthorales en insectos encontrados en cultivos agrícolas en la Provincia de Buenos Aires, Argentina: Zoophthora radicans Batko (Brefeld; Entomophthora planchoniana Cornu y Pandora gammae (Weiser Humber. Se incluyen las medidas de las estructuras fúngicas.Pathogenic fungi of insects from Argentina (Zygomycetes: Entomophthorales. Three species of Entomophthorales entomopathogenic fungi (Zygomycotina: Zygomycetes have been identified from insects in agricultural crops (Buenos Aires Province, Argentina: Zoophthora radicans Batko (Brefeld; Entomophthora planchoniana Cornu and Pandora gammae (Weiser Humber. Fungal structure measurements are reported. Rev. Biol. Trop. 54(2: 311-315. Epub 2006 Jun 01.

  20. Dung pat nesting by the solitary bee, Osmia (Acanthosmiodes) integra (Megachilidae: Apiformes).

    Science.gov (United States)

    Solitary bees nest in a diversity of substrates, typically soil, but also wood, stems and twigs. A new and novel substrate is reported here, dried cattle dung. Two species of Osmia bees were found nesting in dung in Wyoming. One species, O. integra, otherwise nests shallowly in soil. Nests were ...

  1. Validation of Repeated Endothelial Function Measurements Using EndoPAT in Stroke

    DEFF Research Database (Denmark)

    Hansen, Aina S; Butt, Jawad H; Holm-Yildiz, Sonja

    2017-01-01

    BACKGROUND: Decreased endothelial function (EF) may be a prognostic marker for stroke. Measuring pharmacological effects on EF may be of interest in the development of personalized medicine for stroke prevention. In this study, we assessed the reliability of repeated EF measurements using a pulse......%, mean age 35.85 ± 3.47 years) and 21 stroke patients (men 52%, mean age 66.38 ± 2.85 years, and mean NIHSS 4.09 ± 0.53) under standardized conditions. EF was measured as the reactive hyperemia index (RHI), logarithm of RHI (lnRHI), and Framingham RHI (fRHI). Measurements were separated by 1.5 and 24 h...

  2. White and Black Uterine contraction labour in regularity during patIents

    African Journals Online (AJOL)

    1983-04-02

    Apr 2, 1983 ... Period 1.immediately preceded deli- very, period 2 started }l/2 hours hefore delivery, and period 3 started 21/ 2hours before delivery. During each of these periods the number ofcontractions was first counted. Then the distances between successive contractions were measured from base to base (B-B) and ...

  3. JENIS TANAMAN INANG DAN MASA INKUBASI PATOGEN BOTRYODIPLODIA THEOBROMAE PAT. PENYEBAB PENYAKIT KULIT DIPLODIA PADA JERUK

    Directory of Open Access Journals (Sweden)

    Salamiah, Badruzsaufari, dan Muhammad Arsyad .

    2011-11-01

    Full Text Available Alternative hosts and Incubation period of Botryodiplodia theobromae the causal of  diplodia bark diseases on citrus. Citrus is one of the important horticulture commodities in South Kalimantan. Citrus growers in the region encounter diplodia disease caused by a genus of Botryodiplodia.  There is no single method practiced today proved to be effective control for the disease. Insufficient information of the pathogen life cycle is considered to contribute in  the failure of disease management.   Information of the alternative hosts and incubation period of the pathogens is  very crucial in the diseases management. The experiments were carried out at the Laboratory of Plant Diseases and at a Glass House of the Department of Plant Pests and Diseases of the Faculty of Agriculture, Lambung Mangkurat University in Banjarbaru from March – October 2006. The experiments were conducted in three phases, i.e. (1 identification of pathogen, (2 the study of alternative hosts, and (3 the study of incubation periods of the pathogen in the test plants. Results showed that the diplodia disease of citrus “Siam Banjar” was caused by a fungus of the genus Botryodiplodia theobromae.  The pathogen can also  infected chasew  and avocado plants.  The Incubation periods of the pathogen in citrus, chasew, and avocado were  64, 39 and 39 days, respectively.

  4. Genetic mental services for retardation. patIents with seve.re

    African Journals Online (AJOL)

    1982-01-04

    Jan 4, 1982 ... Care of Mentally Deficient Persons in the RSA (1967) dermed persons with mental .... hensive genetic service for patients with mental retardation and ..... servIces. There are numerous homes and institutions for the mentally.

  5. A PAT-based qualification of pharmaceutical excipients produced by batch or continuous processing.

    Science.gov (United States)

    Hertrampf, A; Müller, H; Menezes, J C; Herdling, T

    2015-10-10

    Pharmaceutical excipients have an influence on the main requirements for medicinal products (viz., quality, safety and efficacy) but also on their manufacturability. During product lifecycle it may become necessary to introduce minor changes (e.g., to continuously improve it) or major changes in the validated process (e.g., moving it to a new production site, replacing process version or even disruptively changing processing type). Those changes can influence the critical to quality attributes of the product. Therefore, it is important to enhance process understanding to avoid the risk of any significant quality changes. Process analytical technology can support better decision making and risk-management as required in quality by design - viz., by many pharmaceutical regulatory authorities. This study compares the quality of the pharmaceutical excipient sodium carbonate (anhydrous) produced either in a batch or a continuous process. For continuous processing two different production lines were available that differed on the dryer and crystallizer types used. Therefore their influence on critical to quality attributes of sodium carbonate was investigated for each of the three processing alternatives. The overall goal was to identify which of the continuous processes ensures a similar product quality to batch processing. Namely, changes on chemical and physical attributes of the product were investigated with Raman spectroscopy, laser diffraction and X-ray powder diffraction. Principal component analysis, a very common multivariate analysis technique, was applied to extract relevant information from small differences at multiple spectral regions from samples from each process type and from each analytical technique used. Changing processing from batch to continuous improved consistency of certain attributes (e.g., particle size distribution) but affected others. However, the increased process/product knowledge gained can lead to an enhanced control strategy and ensure a similar product quality is obtained from distinct process versions. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Acquisition of a Spinning Disk Confocal Microscope to Enhance Research and Teaching Capabilities in the STEM Fields at Howard University

    Science.gov (United States)

    2015-05-13

    women ages 15-44) and some of its known causes (i.e. ovulation problems and low sperm count ), people are still unable to conceive even when 2...burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching...haploid gametes, oocytes and sperm , are produced. Errors in meiosis can result in serious issues such as infertility, birth defects or tumorigenesis

  7. Paradigms and Barriers: How Habits of Mind Govern Scientific Beliefs, by Howard Margolis. University of Chicago Press, Chicago, 1993

    Directory of Open Access Journals (Sweden)

    Andrew L. Christenson

    1993-11-01

    Full Text Available Habits of mind, like physical habits, are usually not explicitly taught or recognized are learned slowly, and are changed with difficulty, if at all. Habits of mind are efficient ways of thinking that have a strong selective value in science and in human life at large. The focus of this book is upon those unfortunate, but fairly rare, situations in science where habits of mind get in the way of understanding the world.

  8. Transmission of Different Nucleopolyhedroviruses by Two Ectoparasitoids – Bracon hebetor Say (Hymenoptera: Braconidae and Euplectrus plathypenae (Howard (Hymenoptera: Eulophidae

    Directory of Open Access Journals (Sweden)

    Emanouela E. Stoianova

    2010-01-01

    Full Text Available The transmission of nucleopolyhedroviruses (NPVs of Autographa gamma (AgNPV,Mamestra brassicae (MbNPV, Lacanobia oleraceae (LoNPV, Helicoverpa armigera (HaNPVand Xantia c-nigrum (XnNPV to their relevant larvae by the ectoparasitoid Bracon hebetorand the transmission of the multiple-enveloped NPVs of Spodoptera exigua (SeMNPV andSpodoptera frugiperda (SfMNPV by the ectoparasitoid Euplectrus plathypenae was examined.Two methods of contamination of the both parasitoids (exposure to infected hostsand total body surface and two subsequent transmissions of the viruses by Bracon hebetorto healthy hosts were tested. The results showed that both parasitoids were capable tobe mechanical vectors of the tested NPVs. Every Bracon hebetor female was able to transmitsubsequently twice the virus in 27% to 52.2% of the five Noctuidae species by preliminaryexposing to infected larvae. The second method of contamination (applying virus suspensionto the total body surface of the parasitoid was also efficient causing virus infection inbetween 29.4% and 54.15% of the larvae.The parasitoid E. plathypenae transmited the virus from infected to noninfected larvaein 20% and 25.57% of the S. frugiperda and S. exigua larvae, and 6.43% and 11.10%, respectivelyof them died from the virus infection. The same observation was established by thesecond method of contamination – respectively 33.33% and 40% infection and between13.23% and 16.67% mortality. The mortality of all tested larvae exposed to virus contaminated parasitoids was higherwhen the parasitoid entire body surface had been artificially contaminated with the virusthan when the parasitoid itself was previously allowed to oviposit the larvae.

  9. Transmission of Different Nucleopolyhedroviruses by Two Ectoparasitoids – Bracon hebetor Say (Hymenoptera: Braconidae) and Euplectrus plathypenae (Howard) (Hymenoptera: Eulophidae)

    OpenAIRE

    Emanouela E. Stoianova; Nikolay A. Balevski

    2010-01-01

    The transmission of nucleopolyhedroviruses (NPVs) of Autographa gamma (AgNPV), Mamestra brassicae (MbNPV), Lacanobia oleraceae (LoNPV), Helicoverpa armigera (HaNPV) and Xantia c-nigrum (XnNPV) to their relevant larvae by the ectoparasitoid Bracon hebetor and the transmission of the multiple-enveloped NPVs of Spodoptera exigua (SeMNPV) and Spodoptera frugiperda (SfMNPV) by the ectoparasitoid Euplectrus plathypenae was examined. Two methods of contamination of the both parasitoids (exposure to ...

  10. Antinociceptive and Anti-inflammatory Effects of a Lectin-Like Substance from Clitoria fairchildiana R. Howard Seeds

    Directory of Open Access Journals (Sweden)

    Tatiane Santi-Gadelha

    2012-03-01

    Full Text Available Lectins are proteins that have the ability to bind specifically and reversibly to carbohydrates and glycoconjugates, without altering the structure of the glycosyl ligand. They are found in organisms such as viruses, plants and humans, and they have been shown to possess important biological activities. The objective of this study was to purify and characterize lectins in the seeds of Clitoria fairchildiana, as well as to verify their biological activities. The results indicated the presence of a lectin (CFAL in the glutelin acid protein fraction, which agglutinated native rabbit erythrocytes. CFAL was purified by column chromatography ion-exchange, DEAE-Sephacel, which was obtained from a peak of protein retained in the matrix by applying 0.5 M NaCl using the step-wise method. Electrophoretic analysis of this lectin in SDS-PAGE indicated a two band pattern protein molecular mass of approximately 100 and 116 kDa. CFAL proved to be unspecific to all carbohydrates/glycoconjugates in common use for the sugar inhibition test. This lectin showed no significant cytotoxicity to human red blood cells. It was observed that CFAL has anti-inflammatory activity in the paw edema induced by carrageenan model, in which a 64% diminution in edema was observed. Antinociceptive effects were observed for CFAL in the abdominal writhing test (induced by acetic acid, in which increasing doses of the lectin caused reduction in the number of contortions by up to 72%. It was concluded that the purified and characterized lectin from the seeds of Clitoria fairchildiana has anti-inflammatory and antinociceptive activity, and is not cytotoxic to human erythrocytes.

  11. 77 FR 76457 - Howard Hughes Medical Institute, et al.; Notice of Consolidated Decision on Applications for Duty...

    Science.gov (United States)

    2012-12-28

    ... biomaterials such as starches, lignin, and proteins, and compare them with styrenics and petroleum based... reactivity before and after applying a specified pressure and temperature inside a vacuum chamber inside the...

  12. 77 FR 20009 - Howard Hughes Medical Institute, et al.; Notice of Consolidated Decision on Applications for Duty...

    Science.gov (United States)

    2012-04-03

    ... Importation Act of 1966 (Pub. L. 89-651, as amended by Pub. L. 106-36; 80 Stat. 897; 15 CFR part 301). Related... instrument. Dated: March 26, 2012. Gregory W. Campbell, Director, Subsidies Enforcement Office, Import...

  13. 2004 Maryland Department of Natural Resources LiDAR: Anne Arundel, Charles, Howard and St. Mary's Counties

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Light Detection and Ranging (LIDAR) is a method of locating objects on the ground using aerial-borne equipment. It is similar to RADAR or SONAR in that the two-way...

  14. Rezhissjor Ron Hauard : ja snimal "Kod da Vinsthi" ne dlja teh, kto tshital roman / Ron Howard ; interv. Stass Tõrkin

    Index Scriptorium Estoniae

    Howard, Ron

    2006-01-01

    6. mai ajalehes ilmunud intervjuu järg. Filmi "Da Vinci kood" võtetest Louvre'is, Lincolni katedraalis ja raamatu autori Dan Browni suhtumisest ekraniseeringusse. Ajakirjanikele näidatud filmikatked : "Kak rozhala Maria Magdalina"

  15. John Howard Marsden (1803–1891 First Disney Professor of Archaeology at the University of Cambridge 1851–1865

    Directory of Open Access Journals (Sweden)

    Michael Leach

    2007-05-01

    Full Text Available Although there were ten chairs of archaeology at universities in Germany, and one in France, by the mid-nineteenth century, in Great Britain it was the amateur societies and museums (the British Museum in particular that encouraged the study of this subject. In 1851 John Disney established the first university chair in Great Britain at Cambridge University. His proposal was initially received with considerable caution by the governing body of the university, and was only accepted by the narrowest margin of eight votes to seven. His agreement with the University of Cambridge stipulated that six lectures a year should be given on the subject of ‘Classical, Medieval, and other Antiquities, the Fine Arts and all matters and things connected therewith’ (Clark 1904, 222–225. However university archaeology was slow to establish its academic credibility nationally, and it was more than thirty years before Oxford University established its chair of classical archaeology. The Cambridge Board of Anthropological Studies, which included instruction in prehistoric archaeology, was not created until 1915, and as late as 1945 there were still only a few university lecturers in archaeology in Great Britain. It was not until 1946 that Oxford University appointed a Professor of Prehistoric Archaeology (Wilson 2002, 153; Daniel 1976, 6–12; Smith 2004, 4–5, 53–54.

  16. Anhaia Mello's contributions to urbanism of the city of São Paulo: from Ebenezer Howard to the Chicago School

    Directory of Open Access Journals (Sweden)

    Rodrigo Alberto Toledo

    2013-06-01

    Full Text Available This article draws an analytical panel of the main contributions and interpretations of Anhaia Mello about the problem of growing cities from the perspective of urbanism in the city of São Paulo. Based on a broad review of the literature, this article describes how urban planning migrated to academia and simultaneously to city ordinances, which resulted in the regulatory framework of land use and occupancy that ultimately produced “The Regional São Paulo Plan.” Research in the FAU-USP library revealed family documents and collections that helped reconstruct the intellectual history and career of urban planner and professor Anhaia Mello. The author of this paper organized the data gathered from these collections and compared them to the literature to reconstruct Anhaia Mello’s thoughts on how the city of São Paulo should grow in the mid-20th century. The analyses produced by Anhaia Mello served as a guide to identify the crystallization of a planning proposal for the city, which believed in reversing the metropolitan cycle and containing urban growth by applying the garden-city concept defended by Le Corbusier and the Chicago school.

  17. Order Denying the Petition to Object to the Eastern Kentucky Power Coop. William C. Dale Power Station, Ford, Kentucky, Title V Operating Permit

    Science.gov (United States)

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  18. Myxomatosis: changes in the epidemiology of myxomatosis coincident with the establishment of the European rabbit flea Spilopsyllus cuniculi (Dale) in the Mallee region of Victoria.

    Science.gov (United States)

    Shepherd, R C; Edmonds, J W

    1978-12-01

    Outbreaks of myxomatosis during the winter or spring have coincided with the establishment of the European rabbit flea in the Mallee region. The severity of these outbreaks has varied from causing complete suppression of the normal spring increase in rabbit numbers to being completely ineffective in a year in which late spring rains allowed rabbit breeding to extend into the early summer.In 1973 and 1974 effective spring myxomatosis caused heavy mortality in kittens before they emerged from the warrens. The age of the population increased as the result of few young rabbits coming into the population and of the lessened stress on old rabbits in a low summer-autumn population. This effect was reversed in the late-breeding year, 1976, when flea numbers were apparently too low to maintain a spring outbreak and rabbit numbers increased rapidly.

  19. Myxomatosis: passive immunity in the offspring of immune rabbits (Oryctolagus cuniculus) infested with fleas (Spilopsyllus cuniculi Dale) and exposed to myxoma virus.

    Science.gov (United States)

    Sobey, W R; Conolly, D

    1975-02-01

    Kittens with maternal antibodies to myxoma virus, the offspring of rabbits which had recovered from myxomatosis, were exposed to fleas contaminated with myxoma virus and/or contact with infected rabbits from birth. All kittens died or became infected before 8 weeks of age. When compared with adult animals similarly infected the kittens showed no advantage in terms of survival time or recovery rate attributable to maternal antibodies. Flea transmission of virus was found more effective than contact transmissions.

  20. De essentie van de daling in het aantal verkeersdoden : ontwikkelingen in 2004 en 2005, en nieuwe prognoses voor 2010 en 2020.

    NARCIS (Netherlands)

    Stipdonk, H.L. Aarts, L.T. Schoon, C.C. & Wesemann, P.

    2006-01-01

    The essence of the decrease in the number of road deaths; Developments in 2004 and 2005, and new prognoses for 2010 and 2020. During the last 15 to 20 years there was a 2.5% annual decrease in the number of road deaths. This decrease is attributed to all kinds of important, gradual improvements of

  1. L'application des déchets traités de l'algue Gelidium sesquipédale ...

    African Journals Online (AJOL)

    AKA Boko

    L'acidité est déterminée par titrage de 10ml de la culture pure, par une solution alcaline. (NaOH) N/9, en présence de phénol phtaléine comme indicateur coloré. L'évaluation numérique est obtenue par l'application de la formule suivante. Utiliser un éditeur mathématique pour écrire la formule : é. 3-1-3. Test antibactérien.

  2. Buurtdynamiek en slachtofferschap van criminaliteit : Een studie naar de effecten van sociaal-economische stijging, daling en stabiliteit in Nederlandse buurten

    NARCIS (Netherlands)

    Wilsem, Johan van; Wittebrood, Karin; Graaf, Nan Dirk de

    2003-01-01

    Neighbourhood dynamics and crime victimization: A study on the effects of socio-economic improvement, decline, and stability in Dutch neighbourhoods Changes in neighbourhood status primarily result from the selective in- and out-migration of income groups. In turn, these changes are related to the

  3. 76 FR 76449 - Post Office Closing

    Science.gov (United States)

    2011-12-07

    ... the closing of the Spring Dale, West Virginia post office has been filed. It identifies preliminary... Postal Service's determination to close the Spring Dale post office in Spring Dale, West Virginia. The...

  4. NIR spectroscopy as a process analytical technology (PAT) tool for monitoring and understanding of a hydrolysis process.

    Science.gov (United States)

    Wu, Zhisheng; Peng, Yanfang; Chen, Wei; Xu, Bing; Ma, Qun; Shi, Xinyuan; Qiao, Yanjiang

    2013-06-01

    The use of near infrared spectroscopy was investigated as a process analytical technology to monitor the amino acids concentration profile during hydrolysis process of Cornu Bubali. A protocol was followed, including outlier selection using relationship plot of residuals versus the leverage level, calibration models using interval partial least squares and synergy interval partial least squares (SiPLS). A strategy of four robust root mean square error of predictions (RMSEP) values have been developed to assess calibration models by means of the desirability index. Furthermore, multivariate quantification limits (MQL) values of the optimum model were determined using two types of error. The SiPLS(3) models for L-proline, L-tyrosine, L-valine, L-phenylalanine and L-lysine provided excellent accuracies with RMSEP values of 0.0915 mg/mL, 0.1605 mg/mL, 0.0515 mg/mL, 0.0586 mg/mL and 0.0613 mg/mL, respectively. The MQL ranged from 90 ppm to 810 ppm, which confirmed that these models can be suitable for most applications. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Actividad antibacteriana de algunas especies medicinales de Eupatorium contra bacterias patógenas resistentes a antibióticos

    Directory of Open Access Journals (Sweden)

    Edgar García-Sánchez

    2015-07-01

    Full Text Available Thirty six samples arising from hexane, dichloromethane, and methanol extracts from four medicinal Eupatorium species were screened against Gram positive and Gram negative resistant bacteria associated with nosocomial infections by disk diffusion method. The best antibacterial extracts were selected by correspondence analysis. The hexane extracts showed high inhibition against clinical isolated bacteria. The qualitative chemical analysis was realized in the best antibacterial hexane extracts. The main components identified were triterpenes and benzopyran compounds which of extensively had been reported their antibacterial activities. Our results showing that medicinal Eupatorium species studied in this work have metabolites secondary antibacterial particularly against antibiotic resistant strains, Klebsiella pneumoniae and Staphylococcus aureus and validate their uses in traditional medicine

  6. Peripheralising Patriarchy? Gender and Identity in Post-Soviet Art : a View from the West / Pat Simpson

    Index Scriptorium Estoniae

    Simpson, Pat

    2004-01-01

    Ida-Euroopa maade 1990. aastate kunstielust lääne-eurooplase pilgu läbi näituste "After the Wall", "Private Views", "Manifesta 2" jt põhjal. Eesti kunstnikest mainitakse Jaan Toomikut, Raoul Kurvitzat, Inessa Josingut, Mare Trallat

  7. Focused beam reflectance method as an innovative (PAT) tool to monitor in-line granulation process in fluidized bed.

    Science.gov (United States)

    Alshihabi, Firas; Vandamme, Thierry; Betz, Gabriele

    2013-02-01

    Fluidized bed granulation is a commonly used unit operation in the pharmaceutical industry. But still to obtain and control the desired granule size is challenging due to many process variables affecting the final product. Focused beam reflectance measurement (FBRM, Mettler-Toledo, Switzerland) is an increasingly popular particle growth analysis technique. FBRM tool was installed in two different locations inside a fluidized bed granulator (GPCG2, Glatt, Binzen) in order to monitor the granulation growth kinetics. An experimental design was created to study the effect of process variables using FBRM probe and comparing the results with the one's measured by sieve analysis. The probe location is of major importance to get smooth and robust curves. The excess feeding of binder solution might lead to agglomeration and thus to process collapse, however this phenomenon was clearly detected with FBRM method. On the other hand, the process variables at certain levels might affect the FBRM efficiency by blocking the probe window with sticky particles. A good correlation was obtained (R(2) = 0.95) between FBRM and sieve analysis mean particle size. The proposed in-line monitoring tool enables the operator to select appropriate process parameters and control the wet granulation process more efficiently.

  8. Ação de herbicidas sobre mecanismos de defesa das plantas aos patógenos

    OpenAIRE

    Rizzardi Mauro Antônio; Fleck Nilson Gilberto; Agostinetto Dirceu; Balbinot Jr. Alvadi Antônio

    2003-01-01

    As plantas necessitam defender-se continuamente do ataque de agentes biológicos e de estresses do ambiente. A imobilidade e a falta de sistema imunológico, como ocorre em animais, fizeram com que as plantas desenvolvessem mecanismos de defesa, em que cada célula possui tanto capacidade de defesa induzida quanto pré-formada. No entanto, esses mecanismos podem ser influenciados pelo uso de herbicidas. A presente revisão objetivou apresentar os efeitos de herbicidas em mecanismos de defesa das p...

  9. Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study.

    Science.gov (United States)

    von Stosch, Moritz; Hamelink, Jan-Martijn; Oliveira, Rui

    2016-05-01

    Process understanding is emphasized in the process analytical technology initiative and the quality by design paradigm to be essential for manufacturing of biopharmaceutical products with consistent high quality. A typical approach to developing a process understanding is applying a combination of design of experiments with statistical data analysis. Hybrid semi-parametric modeling is investigated as an alternative method to pure statistical data analysis. The hybrid model framework provides flexibility to select model complexity based on available data and knowledge. Here, a parametric dynamic bioreactor model is integrated with a nonparametric artificial neural network that describes biomass and product formation rates as function of varied fed-batch fermentation conditions for high cell density heterologous protein production with E. coli. Our model can accurately describe biomass growth and product formation across variations in induction temperature, pH and feed rates. The model indicates that while product expression rate is a function of early induction phase conditions, it is negatively impacted as productivity increases. This could correspond with physiological changes due to cytoplasmic product accumulation. Due to the dynamic nature of the model, rational process timing decisions can be made and the impact of temporal variations in process parameters on product formation and process performance can be assessed, which is central for process understanding.

  10. Decay of Fecal Indicator Bacterial Populations and Bovine-Associated Source-Tracking Markers in Freshly Deposited Cow Pats

    Science.gov (United States)

    Understanding the survival of fecal indicator bacteria (FIB) and microbial source-tracking (MST) markers is critical to developing pathogen fate and transport models. Although pathogen survival in water microcosms and manure-amended soils is well documented, little is known about...

  11. Nuclear power - a (too) pat solution. An energy picture book. Das faule Ei des Kolumbus. Ein Energiebilderbuch

    Energy Technology Data Exchange (ETDEWEB)

    Vester, F

    1979-01-01

    This popular book in 'window' form attempts to give a picture of the complex economic and social consequences of a further development of nuclear power utilisation. The advantages of nuclear power are listed, and a critical balance is established for the negative consequences of an all-nuclear energy use for economy, environment, and society.

  12. Patógenos e indicadores microbiológicos de calidad del agua para consumo humano

    Directory of Open Access Journals (Sweden)

    Sandra Ríos-Tobón

    2017-05-01

    Full Text Available Las mejoras en el suministro de agua son oportunidades para solucionar problemas de Salud Pública. De ahí la importancia de establecer modelos de evaluación y gestión integral que garanticen su calidad. Actualmente hay múltiples metodologías para detectar la contaminación microbiana del agua. Sin embargo, los elevados costos que representan, los tiempos de análisis y aislamiento en cultivo de microorganismos, han sido obstáculo para establecer la calidad microbiana del agua para consumo humano. El uso de microorganismos bioindicadores de calidad del agua disminuye los costos y facilita la implementación de medidas eficientes de tratamiento, control del agua y de enfermedades asociadas a su transmisión. El objetivo de la revisión fue describir los principales indicadores microbiológicos empleados para la evaluación del agua potable, como elementos clave para proponer un nuevo esquema de monitoreo en Colombia. Los resultados permiten considerar como bioindicadores, además de las bacterias y protozoos establecidos en la norma, algunos agentes microbianos como virus u otras bacterias y parásitos. Por otro lado indican la necesidad de establecer valores de referencia y definir los microorganismos a emplear con base en evaluaciones específicas de la situación microbiana del agua en monitoreos de validación, operación y verificación. Esta revisión aporta información importante para la actualización de la norma colombiana con base en el conocimiento de estándares internacionales, nacionales y locales.

  13. 'Don't save her'- Sigmund Freud meets Project Pat: the rescue motif in hip-hop.

    Science.gov (United States)

    Fulmer, Richard H

    2008-08-01

    Freud originally explicated the dynamics of rescue wishes by describing men who fell in love with prostitutes. He saw this attempt at attachment as driven by the man's wish to repay his parents for giving him life. Many subsequent writers shift this emphasis, seeing rescue wishes as motivated by aggressive oedipal competition with the father. This article highlights the attachment aspects of Freud's original conception and traces how writers in the last three decades use the family romance rather than Oedipus as a model to view rescue wishes as having a more tender aspect. Rescue wishes are especially characteristic of the developmental stage of young adulthood. They at once attempt to repay the parental debt the young adult feels and serve as practice for the vicissitudes of the couple bond and the benign sacrifices of parenthood. Popular culture contains many vivid examples of Freud 's original description of the rescue-motif. A detailed examination of the rap song, Don't save her, demonstrates all the elements of Freud's original conception and the interpersonal risks of the rescue relationship. Three additional rap songs by other artists are briefly analyzed to show the extensive occurrence of the wish to rescue and its psychic and interpersonal dangers.

  14. Introducing process analytical technology (PAT) in filamentous cultivation process development: comparison of advanced online sensors for biomass measurement

    DEFF Research Database (Denmark)

    Rønnest, Nanna Petersen; Stocks, Stuart M.; Eliasson Lantz, Anna

    2011-01-01

    cultivation data, such as the carbon dioxide evolution rate (CER) and the concentration of dissolved oxygen. Prediction models for the biomass concentrations were estimated on the basis of the individual sensors and on combinations of the sensors. The results showed that the more advanced sensors based on MWF...... and scanning DE spectroscopy did not offer any advantages over the simpler sensors based on dual frequency DE spectroscopy, turbidity, and CER measurements for prediction of biomass concentration. By combining CER, DE spectroscopy, and turbidity measurements, the prediction error was reduced to 1.5 g...

  15. Experimentation and simulation of H.S.L.A. sheet metal bending bent pats behaviour's prediction during working life

    International Nuclear Information System (INIS)

    Avril, Ludovic

    2003-01-01

    A pulsed Nd-YAG laser is used to irradiate and alloy X30Cr13 stainless steel by surface melting, with incorporation of boron or hexagonal boron nitride (h-BN), and to obtain thick coatings: multiphase borided alloys or metal-ceramic composites. The metallographic analyses allow to determine the thickness for each coating (melting zone) and reveal characteristic solidification microstructures: planar front and cellular dendrites. Optical characteristics of the laser beam are measured: divergence, focal length spot radius and power distribution in the focal plane. Heat effect simulations are based on the finite difference modelling of the temporal progression of temperature distribution in the steel irradiated by scanning of the pulsed beam. Melting zone thickness is computed and progression of melting front during irradiation is simulated and so, a better description of the conditions of material incorporation by successive melting and solidifications becomes possible. The mechanical properties, elastic modulus and hardness, of the different coatings are determined from nano-indentation tests. Under optimal irradiation conditions, the hardness reaches 14 GPa for composite coating and 10 GPa for borided alloy, whereas that for untreated steel is 4 GPa. Friction and wear tests are systematically performed in a ball-on-disc configuration, at 25 C under various loads (1 to 10 N), then at 300 and 500 C under 2 N. At ambient temperature, the dry sliding on ruby ball of these two types of coatings is characterized by a reduced friction coefficient and a weak wear rate, compared with the untreated steel, revealing a very reinforced resistance towards adhesive and/or abrasive wear. On the other hand, their wear resistance is decreased from 300 C, in the spite of the significant lowering of friction coefficient. (author)

  16. Mutations in cyr1 and pat1 reveal pheromone-induced G1 arrest in the fission yeast Schizosaccharomyces pombe

    DEFF Research Database (Denmark)

    Davey, William John; Nielsen, O; Nielsen, Olaf

    1994-01-01

    Investigations into sexual differentiation and pheromone response in the fission yeast Schizosaccharomyces pombe are complicated by the need to first starve the cells of nitrogen. Most mating-related experiments are therefore performed on non-dividing cells. Here we overcome this problem by using...

  17. Process analytical technology (PAT) in insect and mammalian cell culture processes: dielectric spectroscopy and focused beam reflectance measurement (FBRM).

    Science.gov (United States)

    Druzinec, Damir; Weiss, Katja; Elseberg, Christiane; Salzig, Denise; Kraume, Matthias; Pörtner, Ralf; Czermak, Peter

    2014-01-01

    Modern bioprocesses demand for a careful definition of the critical process parameters (CPPs) already during the early stages of process development in order to ensure high-quality products and satisfactory yields. In this context, online monitoring tools can be applied to recognize unfavorable changes of CPPs during the production processes and to allow for early interventions in order to prevent losses of production batches due to quality issues. Process analytical technologies such as the dielectric spectroscopy or focused beam reflectance measurement (FBRM) are possible online monitoring tools, which can be applied to monitor cell growth as well as morphological changes. Since the dielectric spectroscopy only captures cells with intact cell membranes, even information about dead cells with ruptured or leaking cell membranes can be derived. The following chapter describes the application of dielectric spectroscopy on various virus-infected and non-infected cell lines with respect to adherent as well as suspension cultures in common stirred tank reactors. The adherent mammalian cell lines Vero (African green monkey kidney cells) and hMSC-TERT (telomerase-immortalized human mesenchymal stem cells) are thereby cultured on microcarrier, which provide the required growth surface and allow the cultivation of these cells even in dynamic culture systems. In turn, the insect-derived cell lines S2 and Sf21 are used as examples for cells typically cultured in suspension. Moreover, the FBRM technology as a further monitoring tool for cell culture applications has been included in this chapter using the example of Drosophila S2 insect cells.

  18. Influence of culture media and environmental factors on mycelial growth and sporulation of Lasiodiplodia theobromae (Pat.) Griffon and Maubl.

    Science.gov (United States)

    Saha, A; Mandal, P; Dasgupta, S; Saha, D

    2008-05-01

    Lasiodiplodia theobromae, a common tea (Camellia sinensis) pathogen, usually does not sporulate or sporulates poorly in common media, which makes spore production difficult. In this study the effects of culture media, carbon source, nitrogen source, temperature, pH and light on mycelial growth and sporulation were evaluated. Among several carbon sources tested, glucose and sucrose were found superior for growth. Potassium nitrate supplemented media showed maximum growth amongst the tested inorganic nitrogen sources while peptone produced maximum growth among the tested organic nitrogen sources. Tea root extract supplemented potato dextrose agar medium was found to be the most suitable for mycelial growth and sporulation of L. theobromae. The fungus grow at temperatures ranging from 40 to 36 degrees C, with optimum growth at 28 degrees C and no growth was noted at 40 degrees C. There was no significant effect of different light period on growth of L. theobromae, but light enhanced sporulation. The fungus grow at pH 3.0-8.0 and optimum growth was observed at pH 6.0. Tea root extract supplemented potato dextrose agar medium with pH 6.0 was the most suitable for production of conidia of L. theobromae at 28 degrees C. Hence this media may be recommended for inoculum production for further studies.

  19. Cochlear ımplantatıon ın a patıent wıth usher's syndrome

    OpenAIRE

    Derinsu, Ufuk; Ciprut, Ayca

    2002-01-01

    Usher's Syndrome is an autosomal recessive disorder characterized by congenital hearing loss and retinitis pigmentosa. Usher’s Syndrome patients with severe to profound sensorineural hearing loss can be considered as candidates for cochlear implantation. This case study reports a deaf-blind with Usher's Syndrome who received a cochlear implant, the audiological evaluation is presented and the therapy sessions are discussed. The patient demonstrated good performance overtime after the impla...

  20. Inhibition of Listeria monocytogenes by pomegranate (Punica granatum) peel extract in meat paté at different temperatures

    NARCIS (Netherlands)

    Hayrapetyan, H.; Hazeleger, W.C.; Beumer, R.R.

    2012-01-01

    Natural antimicrobials are being more and more considered as alternative approach for controlling growth of microorganisms in food. The objective of this study was to evaluate the pomegranate extract’s (PE) potential to be used as a natural preservative in ready to eat meats. Listeria monocytogenes

  1. Cryptosporidium y blastocistis hominis como agentes patógenos en el síndrome diarréico

    Directory of Open Access Journals (Sweden)

    Ligia I. Moncada

    1989-12-01

    Full Text Available En una comunidad de escasos recursos de Bogotá se tomaron muestras de heces de niños menores de diez años con diarrea y de niños sin diarrea. Las muestras del grupo de estudio y del grupo control resultaron negativas para el Cryptosporidium. Se encontraron positivas para Blastocistis hominis 17 muestras del grupo de estudio (8.3%. y 5 del grupo control (10.4%. Los síntomas predominantes fueron fiebre, dolor abdominal y pérdida del apetito. El B. hominis se asoció con la Escherichia coli, Salmonella campylobacter, E. histiolytica, Giardia lamblia, Ascaris lumbricoides y rotavírus. No se confirmó el papel que en los últimos años se le atribuye al Cryptosporidium y al B. hominis como agentes productores de diarrea.

  2. Seguimiento a patógenos presentes en biosólido empleado como enmienda para revegetalizar un talud

    OpenAIRE

    López Sánchez, Idalia Jacqueline; Acevedo Cifuentes, Diana Rocío; Ordóñez Ante, Carlos Andrés

    2010-01-01

    Con el fin de evaluar la factibilidad del uso del biosólido como enmienda orgánica para el establecimiento de vegetación y el control de procesos erosivos superficiales activos, se seleccionó un corte de carretera ubicado sobrela Variante a Caldas (Antioquia). Para darle amarre y cobertura al suelo, se sembraron dos especies vegetales tipo pasto Brachiaria Decumbens y Kikuyo (Pennisetum clandestinum), utilizando biosólido proveniente de la PTAR San Fernando, mezclado con suelo de la zon...

  3. Factores de virulencia del patógeno intestinal Entamoeba histolytica Virulence factors of the enteric protozoan parasite Entamoeba histolytica

    Directory of Open Access Journals (Sweden)

    Juanita Trejos-Suárez

    2009-06-01

    Full Text Available Entamoeba histolytica es un protozoo entérico causante de la amebiasis intestinal y extraintestinal. Se calcula que 10% de la población mundial está infectada por el complejo Entamoeba histolytica/Entamoeba dispar. Según la OMS, hay 500 millones de nuevas infecciones por año y, aproximadamente, 70.000 a 100.000 muertes a causas de ellas. Este parásito cumple un proceso de invasión muy elaborado, en el cual se secretan y expresan proteínas que le permiten adherirse al epitelio, degradar la matriz extracelular y producir citólisis de las células epiteliales para penetrar dentro de la mucosa. El entendimiento de estos factores de virulencia ha generado múltiples estudios en diferentes áreas de las ciencias biomédicas, desde métodos diagnósticos cada vez más sensibles y específicos hasta candidatos para vacunas, lo que abre nuevas expectativas terapéuticas a raíz de estos estudios.The enteric protozoan parasite Entamoeba histolytica is a human pathogen that causes widespread morbidity and mortality. It is estimated that 10% of the world’s population is infected with the complex Entamoeba histolytica/ Entamoeba dispar. According to the WHO there are 500 million new infections per year and it is the cause of approximately 70,000 - 100,000 deaths. This parasite has a very elaborate process of invasion, where there are expressed and secreted proteins that allow the parasite to adhere to the epithelium, to degrade extracellular matrix and to penetrate epithelial cells within the mucosa. Numerous studies have been carried out to understand how virulence factors work in diverse areas of biomedical sciences. The studies have proposed diagnostic tests to increase the sensitivity and specificity and to find vaccine candidates, which are an opening way to new therapeutic expectations.

  4. Fast freeze-drying cycle design and optimization using a PAT based on the measurement of product temperature.

    Science.gov (United States)

    Bosca, Serena; Barresi, Antonello A; Fissore, Davide

    2013-10-01

    This paper is focused on the use of an innovative Process Analytical Technology for the fast design and optimization of freeze-drying cycles for pharmaceuticals. The tool is based on a soft-sensor, a device that uses the experimental measure of product temperature during freeze-drying, a mathematical model of the process, and the Extended Kalman Filter algorithm to estimate the sublimation flux, the residual amount of ice in the vial, and some model parameters (heat and mass transfer coefficients). The accuracy of the estimations provided by the soft-sensor has been shown using as test case aqueous solutions containing different excipients (sucrose, polyvinylpyrrolidone), processed at various operating conditions, pointing out that the soft-sensor allows a fast estimation of model parameters and product dynamics without involving expensive hardware or time consuming analysis. The possibility of using the soft-sensor to calculate in-line (or off-line) the design space of the primary drying phase is here presented and discussed. Results evidences that by this way, it is possible to identify the values of the heating fluid temperature that maintain product temperature below the limit value, as well as the operating conditions that maximize the sublimation flux. Various experiments have been carried out to test the effectiveness of the proposed approach for a fast design of the cycle, evidencing that drying time can be significantly reduced, without impairing product quality. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. Opciones vacunales contra los virus patógenos de porcinos PRRS y PCV2, un binomio frecuente

    Directory of Open Access Journals (Sweden)

    Marcos Cajero-Juárez

    2017-01-01

    Full Text Available En la última década, el síndrome reproductivo y respiratorio porcino (PRRS, por sus siglas en inglés y las enfermedades asociadas al circovirus porcino tipo 2 (PCV2, por sus siglas en inglés, representan una gran preocupación para la industria porcícola, debido a la afectación de los índices productivos. En consecuencia, su presencia va acompañada de cuantiosas pérdidas económicas. Actualmente, en la mayoría de los centros de producción, se utilizan vacunas clásicas, es decir, elaboradas a partir del virus completo viable ó atenuado. En relación al PCV2, se dispone de pocas vacunas de nueva generación, referidas como aquellas obtenidas a través de la tecnología del ADN recombinante, mientras que, únicamente vacunas clásicas están disponibles contra el virus PRRSV. En este manuscrito, revisamos la naturaleza de los virus PRRSV y PCV2, así también, resaltamos la importancia económica, de acuerdo a los datos de prevalencia nacional e internacional. Además, se incluyen datos de nuevas opciones vacunales, en relación con las vacunas comerciales que, en algunos casos, se ha documentado una baja protección contra cepas heterólogas y cepas de reciente aparición. Por un lado, la investigación en vacunas de nueva generación, ha tenido buena aceptación, debido a la posibilidad de seleccionar la información genética del virus para estimular la respuesta inmune protectora del hospedero y, por otro, porque se acelera el desarrollo de vacunas, e incluso, es posible evitar las infecciones de las cuales es responsable el virus vacunal.

  6. 75 FR 72869 - Louisville & Indiana Railroad Company-Trackage Rights Exemption-CSX Transportation, Inc.

    Science.gov (United States)

    2010-11-26

    ... Belt Subdivision via Dale southeast wye or Dale northeast wye at milepost QSL 1.7, a distance of 2.3... at Dale and milepost QIB 3.2 at CP Woods; (ii) Crawfordsville Branch extending between milepost QSC 1... milepost QIB 5.9 at Dale and milepost QIB 2.9 at CP 1; and (ii) Indianapolis Terminal Subdivision extending...

  7. 77 FR 49360 - Final Flood Elevation Determinations

    Science.gov (United States)

    2012-08-16

    ... confluence. Casey Branch (backwater effects from From the Dale Hollow Lake +663 Unincorporated Areas of Dale Hollow Lake). confluence to Cumberland County. approximately 0.5 mile upstream of the Dale Hollow Lake.... Dale Hollow Lake (Obey River) Entire shoreline within +663 Unincorporated Areas of community...

  8. Stockton Lake Wimmer Collections. Analysis of Prehistoric Artifacts Collected by Howard R. Wimmer from Archeological Sites in the Stockton Lake Project, Cedar and Dade Counties, Missouri

    Science.gov (United States)

    1993-01-01

    1971). The economy of the area continued to improve from the turn of the century through World War II. Buildings and roads were built throughout the...Heavily groud stem Pojectlle point/knife (Big Criee) 1 16.0 Stetmed bitace proximA (Big Creek) 1 15.1 Bifk* stem (Big Creek) 1 5.6 Stemmed Wace proximal

  9. Anthropophilic biting behaviour of Anopheles (Kerteszia neivai Howard, Dyar & Knab associated with Fishermen’s activities in a malaria-endemic area in the Colombian Pacific

    Directory of Open Access Journals (Sweden)

    Jesus Eduardo Escovar

    2013-12-01

    Full Text Available On the southwest Pacific Coast of Colombia, a field study was initiated to determine the human-vector association between Anopheles (Kerteszia neivai and fishermen, including their nearby houses. Mosquitoes were collected over 24-h periods from mangrove swamps, marshlands and fishing vessels in three locations, as well as in and around the houses of fishermen. A total of 6,382 mosquitoes were collected. An. neivai was most abundant in mangroves and fishing canoes (90.8%, while Anopheles albimanus was found indoors (82% and outdoors (73%. One An. neivai and one An. albimanus collected during fishing activities in canoes were positive for Plasmodium vivax , whereas one female An. neivai collected in a mangrove was positive for P. vivax . In the mangroves and fishing canoes, An. neivai demonstrated biting activity throughout the day, peaking between 06:00 pm-07:00 pm and there were two minor peaks at dusk and dawn. These peaks coincided with fishing activities in the marshlands and mangroves, a situation that places the fishermen at risk of contracting malaria when they are performing their daily activities. It is recommended that protective measures be implemented to reduce the risk that fishermen will contract malaria.

  10. Who's at the table? An analysis of ministers' participation in EU Council of Ministers meetings / Carline Howard Grøn, Heidi Houlberg Salomonsen

    Index Scriptorium Estoniae

    Howard Grøn, Caroline

    2015-01-01

    Artiklis analüüsitakse, kuivõrd võtavad liikmesriikide (sh Eesti) esindajad osa Euroopa Liidu Nõukogu istungitest ja kas osavõtjateks on alati ministrid või hoopis kõrged riigiametnikud? Andmed on aastatest 2005-2009

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. DALE JAMIESON. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 3-8 Commentary. Liberating primatology · SINDHU RADHAKRISHNA DALE JAMIESON · More Details Abstract Fulltext PDF ...

  12. Heat Transfer Analysis of an Optimized, Flexible Holder System for Freeze-Drying in Dual Chamber Cartridges Using Different State-of-the-Art PAT Tools.

    Science.gov (United States)

    Korpus, Christoph; Pikal, Michael; Friess, Wolfgang

    2016-11-01

    The aim of this study was to determine the heat transfer characteristics of an optimized flexible holder device, using Tunable Diode Laser Absorption Spectroscopy, the Pressure Rise Test, and the gravimetric procedure. Two different controlled nucleation methods were tested, and an improved sublimation process, "preheated plate," was developed. Tunable Diode Laser Absorption Spectroscopy identified an initial sublimation burst phase. Accordingly, steady-state equations were adapted for the gravimetric procedure, to account for this initial non-steady-state period. The heat transfer coefficient, K DCC , describing the transfer from the holder to the DCC, was the only heat transfer coefficient showing a clear pressure dependence with values ranging from 3.81E-04 cal/(g·cm 2 ·K) at 40 mTorr to 7.38E-04 cal/(g·cm 2 ·K) at 200 mTorr. The heat transfer coefficient, K tot , reflecting the overall energy transfer via the holder, increased by around 24% from 40 to 200 mTorr. This resulted in a pressure-independent sublimation rate of around 42 ± 1.06 mg/h over the whole pressure range. Hence, this pressure-dependent increase in energy transfer completely compensated the decrease in driving force of sublimation. The "flexible holder" shows a substantially reduced impact of atypical radiation, improved drying homogeneity, and ultimately a better transferability of the freeze-drying cycle for process optimization. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  13. Presencia de Patógenos en Almácigos y Semilla de Chile (Capsicum annuum L.) en Aguascalientes y Zacatecas, México

    OpenAIRE

    Velásquez-Valle, Rodolfo; Amador-Ramírez, Mario Domingo; Medina-Aguilar, María Mercedes; Lara-Victoriano, Faustino

    2007-01-01

    Un muestreo realizado en municipios de Aguascalientes y Zacatecas, México, indicó que el 88.4% de los almácigos tradicionales de chile presentaron daños por secadera temprana (damping-off); el área dañada osciló de 1 a 15%. Los hongos Fusarium spp., Rhizoctonia spp. y Alternaria spp. fueron identificados en la superficie de semilla de diversos tipos de chile, así como en plántulas enfermas del mismo cultivo. La fumigación del suelo y la desinfección de la semilla son llevadas a cabo solamente...

  14. Características de aislamientos de Rhizoctonia solani Huhn y su importancia como patógenos de Stylosanthes guianensis (Aubl. Sw.

    Directory of Open Access Journals (Sweden)

    Lenne Jilliam M.

    1986-06-01

    Full Text Available Se encontró considerable variación en el crecimiento, color, zonificación, esclerocios, textura del micelio y en la virulencia de siete aislamientos de R. solani. Como seis aislamientos fueron multinucleados y uno binucleado, se demostró que es indispensable determinar ésta característica en ensayos con R. solani. Los aislamientos se ubicaron en los grupos de anastomosis AG -1, AG-2, AG-4; pero en los ensayos con electroforesis de isoenzirnas los modelos de bandas para los a islamientos probadores de los AG y los probados en éste estudio fueron diferentes, lo que llevó a cuestionar la importancia de los AG. Los ecotípos de Centrosema spp y P. phaseoloides fueron más afectados que los de S. guianensis, D. ovalifolium y S. capitata. La reacción al daño de R. solani fue diferencial en los ecotipos CIAT 1283 (tardío y 184 (común y tuvo mucha relación con la edad; en general, la enfermedad se incrementó con la edad en el eco tipo tardío y disminuyó con ésta o fue independiente en el ecotipo común; el ecotipo más fectado fue el tardío; las pérdidas de forraje no fueron considerables, pero el efecto en la digestibilidad fue notorio; la capacidad de rebrote fue buena en 184. Se observó un estímulo en el crecimiento de las plantas de S.guianensis y D. ovalifolium.Considerable variation was found in the growth, color, zonation, sclerotia, mycelial texture and virulence of seven isolates of R. solani. Six multinuclease and one binuclease isolates were determined, demonstrating that it is indispensable to determine this characteristic in trials with this pathogen. The isolates were placed in three anastomosis group AG -1, AG -2 and AG -4; but with electrophoresis of isoenzymes it was found that the band models were different for the known rest AG iso lates and those isolates proven in this study which questions the importance of anastomosis qroups. Ecotypes of Centrosema spp. and P. phaseoloides were more affected than those of S. guianensis, D. ovalifolium and S. capitata. The reaction on damage by R. solani was differencial for ecotypes C IAT 1283 (tardío and 184 (comrno n and was related to age. In general, the disease increased with age in the tardio and decreased or was independent of age in the cornrnon: the tardio was more affected; forage losses were not cosiderable but the effect on the digestibility was noted; the regrowth capacity was good in the cornrnon. A stimulus in the growth of plants of S. guianensis and D. ovalifolium was observed.

  15. Staphylococcus cohnii spp urealyticus: relato de caso de um patógeno incomum Staphylococcus cohnii spp urealyticus: case report on an uncommon pathogen

    Directory of Open Access Journals (Sweden)

    Pedro Alves d'Azevedo

    2008-04-01

    Full Text Available Staphylococcus coagulase negativos tem surgido como importantes agentes em infecções de pacientes hospitalizados. Neste estudo, relatamos o caso de bacteremia associada a cateter venoso central devido a Staphylococcus cohnii spp urealyticus isolado em hemocultura de um paciente do sexo masculino, 53 anos, internado em hospital geral da cidade de São Paulo. Discutimos nesse relato a dificuldade em identificar rotineiramente esse microrganismo no Laboratório de Microbiologia Clínica. Staphylococcus cohnii spp urealyticus é um microrganismo encontrado na pele dos seres humanos como parte da microbiota normal, podendo em algumas situações causar sérias infecções em humanos.Coagulase-negative Staphylococcus has emerged as an important agent in nosocomial infections. In this study, we report a case of bacteremia associated with a central venous catheter, caused by Staphylococcus cohnii spp urealyticus that was isolated in blood cultures from a 53-year-old male patient who was admitted to a general hospital in the city of São Paulo. We discuss in this report the difficulty in routinely identifying this microorganism in the clinical microbiology laboratory. Staphylococcus cohnii spp urealyticus is a microorganism found in human skin as part of the normal microbiota, and it can cause serious infections in humans, in some situations.

  16. Formálna epistemológia a spoločenské vedy: odpoveď Markéte Patákovej

    Czech Academy of Sciences Publication Activity Database

    Kvasz, Ladislav

    2015-01-01

    Roč. 37, č. 3 (2015), s. 327-360 ISSN 1210-0250 Grant - others:AV ČR(CZ) Fellowship J. E. Purkyně Institutional support: RVO:67985955 Keywords : formal epistemology * Foucault * Kuhn * idealization Subject RIV: AA - Philosophy ; Religion http://hdl.handle.net/11104/0260367

  17. Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayos

    Directory of Open Access Journals (Sweden)

    M. I. Mota

    2010-06-01

    Full Text Available Diarrheal disease continues to be a serious health problem, especially in developing countries. Bloody diarrhea represents approximately 20-30% of all cases and has higher morbidity and mortality. Treatment with antibiotics is beneficial in cases of Shigella, Campylobacter, Yersinia and Salmonella infection, principally in those children with a higher risk of invasive disease. The aims of this study were to detect the bacterial agents associated with bloody diarrhea in children and to determine their antimicrobial susceptibility patterns. Between June 2001 and January 2008, 249 children with bloody diarrhea were studied. Shigella and Shiga toxin-producing Escherichia coli (STEC were recovered from 48 (19.3% and 3 (1.2% of the total of cases, respectively. In 49 out of 249 children, in whom other enteropathogens were investigated, we recovered Campylobacter jejuni from 7 children (14.3%, Salmonella spp. from 2 (4.1% and Aeromonas spp. from 1 (2% in addition to Shigella from 7 children (14.3%. Thirty-four (70% Shigella isolates showed resistance to ampicillin and 13 (27% to trimethoprim-sulfamethoxazole. All Shigella isolates were susceptible to nalidixic acid, ciprofloxacin and ceftriaxone. Salmonella and STEC isolates were susceptible to all antibiotics assayed. Thus, the use of trimethoprim-sulfamethoxazole or ampicillin would not be appropriate for the empirical treatment of Shigella - associated diarrhea.La enfermedad diarreica es un problema de salud importante, especialmente en los países en desarrollo. La diarrea sanguinolenta representa el 20-30% del total de casos y determina una mayor morbimortalidad. La antibioticoterapia es beneficiosa en casos de infección por Shigella, Campylobacter, Yersinia y Salmonella, principalmente en niños con riesgo elevado de enfermedad invasora. Los objetivos del presente trabajo fueron conocer las bacterias asociadas a diarrea sanguinolenta y determinar su patrón de sensibilidad a los antimicrobianos. Entre junio de 2001 y enero de 2008 se estudiaron 249 niños con diarrea sanguinolenta. Shigella y Escherichia coli productor de toxina Shiga (STEC se recuperaron de 48 (19,3% y 3 (1,2% casos, respectivamente. En la subpoblación de 49 niños cuyo estudio coprobacteriológico fue más completo se aisló, además de Shigella (14,3%, Campylobacter jejuni (14,3%, Salmonella spp. (4,1% y Aeromonas spp. (2%. Treinta y cuatro (71% aislamientos de Shigella mostraron resistencia a ampicilina y 13 (27% a trimetoprima-sulfametoxazol. Todos los aislamientos de Shigella fueron sensibles a ácido nalidíxico, ciprofloxacina y ceftriaxona. Los aislamientos de Salmonella y STEC fueron sensibles a todos los antibióticos ensayados. En función de estos resultados, se concluye que el uso de trimetoprima-sulfametoxazol y de ampicilina no sería apropiado para el tratamiento empírico de la diarrea asociada a Shigella.

  18. Klebsiella pneumoniae as a nosocomial pathogen: epidemiology and drug resistance Klebsiella pneumoniae como patógeno intrahospitalario: epidemiología y resistencia

    Directory of Open Access Journals (Sweden)

    Juan Carlos Cataño Correa

    2010-08-01

    Full Text Available

    Worldwide, bacterial resistance is an increasingly serious problem, especially in hospital environments. Staphylococcus aureus and Escherichia coli are the most frequently isolated microorganisms in patients with nosocomial infections. In Medellín, Colombia, however, Klebsiella pneumoniae has become increasingly important in this kind of infection, for which reason this review was carried out.

    It includes the following aspects: microbiology, epidemiology, dissemination, resistance to betalactamic antibiotics and its mechanisms, clinical impact and importance of the problem in this city.

     

    La resistencia bacteriana es un problema serio, de magnitud creciente y presentación universal, que reviste gran importancia, especialmente en los ambientes hospitalarios; los microorganismos más frecuentemente aislados de pacientes con infecciones intrahospitalarias son Staphylococcus aureus y Escherichia coli. En Medellín, sin embargo, Klebsiella pneumoniae ha cobrado gran importancia en años recientes debido a su gran incremento como agente causal de ese tipo de infecciones, lo que motiva esta revisión. Se incluyen los siguientes aspectos: microbiología, epidemiología, diseminación, resistencia a los beta-lactámicos y sus mecanismos, impacto clínico e importancia del problema en la ciudad.

  19. Rol patógeno experimental de la Entamoeba coli asociada al estreptococo hemolítico (en el perro y en el gato

    Directory of Open Access Journals (Sweden)

    Víctor M. Ayulo Robles

    1943-12-01

    Full Text Available Según nuestras observaciones, el cultivo de la Entamoeba coli es fácil de obtenerse cuando se emplea un medio rico en hemoglobina como el que hemos descrito. El 100 de los animales que inoculamos, por vía ileal con la mezcla de cultivos de Entamoeba coli más Streptococo hemolítico y a los que se les suministró bilis de buey en cápsulas de 0.50 gms., alimentados con una dieta rica en carne, reprodujeron el cuadro agudo de, la disenteria amebiana, no obstante de haber usado animales de 2 o más años de edad en las 2 primeras series, siendo las lesiones anatomo-patológicas e histológicas semejantes a las encontradas por otros autores quienes utilizaron para sus experiencias Entamoeba histolytica. De los animales "controles", el 100 % de los inoculaclos solo con Streptococo hemolítico y bilis, sometidos a la misma dieta reprodujeron un sindroine disenteriforme con un cuadro anatomo-patológico e histológico semejante a aquellos que recibieron la mezcla de amebas más Streptoccco, pero, encontrándose solo leucocitos, macrófagos y glóbulos rojos en las heces. Mientras que, de los 6 que solo se inocularon con cultivos de amebas y bilis, sometidos a la misma dieta, 2 de ellos (33.3 7, no presentaron ninguna lesión anatomo-patológica ni amebas en las heces, empero 4 (66.6 % presentaron lesiones anatomo-patológicas de variable intensidad y, en solo 2 de ellos encontramos una que otra ameba, considerando entre estos dos al que murió al día siguiente de la inoculación.

  20. EFEITO DO EXTRATO FOLIAR DE Gossypium arboreum L. (ALGODÃO SOB O CRESCIMENTO MICELIAL DE Lasiodiplodia theobromae (PAT. GRIFFON & MAUBL

    Directory of Open Access Journals (Sweden)

    Caroline da Cruz Vasconcelos

    2017-03-01

    Full Text Available O uso de extratos vegetais tem sido amplamente estudado como controle biológico alternativo de doenças de plantas, especialmente aquelas causadas por fungos patogênicos. Nesse sentido, o objetivo do presente estudo foi avaliar a atividade antifúngica in vitro do extrato bruto etanólico obtido de folhas de algodão (Gossypium arboreum L., Malvaceae em diferentes concentrações sob o desenvolvimento micelial do fungo fitopatogênico Lasiodiplodia theobromae. O ensaio foi conduzido nos Laboratórios de Microbiologia/Fitopatologia/Genética e de Cultivo/Isolamento da Universidade do Estado do Amapá/UEAP, em Macapá, Amapá. Em um Delineamento Inteiramente Casualizado (DIC, seis tratamentos e seis repetições foram organizados: T1 (controle negativo – BDA (Batata-Dextrose-Ágar + 0 mg.mL-1 (extrato foliar; T2 - BDA + 5 mg.mL-1 (extrato foliar; T3 - BDA + 10 mg.mL-1 (extrato foliar; T4 - BDA + 20 mg.mL-1 (extrato foliar; T5 - BDA + 2,5 mL de etanol e T6 (controle positivo - BDA + 2,5 mL de fungicida comercial (Derosal®. As variáveis inibição do crescimento micelial (ICM, índice de velocidade de crescimento micelial (IVCM e área abaixo da curva de cobertura de crescimento micelial (AACCM foram calculadas ao final do experimento. Os resultados mostraram que o extrato bruto etanólico das folhas de G. arboreum não apresentou atividade antifúngica in vitro frente ao fungo L. theobromae nas concentrações testadas. O extrato induziu o crescimento micelial do fungo, especialmente na concentração 10 mg.mL-1, a qual apresentou condição ideal para o desenvolvimento das estruturas do fungo. Palavras-chave: Malvaceae, extrato vegetal, controle biológico, fitopatógeno.

  1. Termoterapia para o controle de patógenos em pós-colheita em frutos da cajazeira = Thermotherapy for post harvest pathogens on Spondias fruits

    Directory of Open Access Journals (Sweden)

    Carlos Henrique de Brito

    2008-01-01

    Full Text Available O tratamento térmico, principalmente água quente, é método alternativo que tem sido utilizado para o controle de doenças e infestações de insetos em frutos póscolheita. O presente trabalho teve como objetivo determinar a combinação de tempo e temperatura adequada para o controle de fungos de pós-colheita em frutos de cajazeira em atmosfera ambiente. No primeiro tratamento, os frutos foram imersos em água quente e no segundo foram expostos ao vapor a 50°C por 0, 10, 20, 30 e 40 minutos para diferentes lotes de frutos. Foram retiradas de cada fruto/tratamento quatro secções, as quais foram incubadas em placas de Petri com BDA, sendo realizadas as avaliações da incidência de fitopatógenos após 7 dias de incubação. Os resultados obtidos demonstraram uma maior incidência de Rhizophus sp. nos tratamentos avaliados e redução de Aspergillus sp. e Fusariumsp., cujo comportamento foi influenciado pelo tratamento termoterápico, podendo ser indicado os tratamentos vapor e banho-maria a 50ºC a partir de 20 minutos como método alternativo no controle pós-colheita de Aspergillus sp. e Fusarium sp. em frutos da cajazeira.Thermal treatment, mainly hot water, is an alternative method that has been used for diseases and pests infestation in post harvest fruits. The present work aimed to determine a combination of correct time x temperature for post harvest fungus control on Spondias fruits. For the first treatment, fruits were dipped on hot water and, for the second, on hot air, both with 50°C for 0, 10, 20, 30 e 40 minutes for different fruit groups. Four pieces were sectioned from each fruit, per treatment, and incubated in Petri dishes with BDA,being evaluated for fungus incidence after seven days incubation. Obtained results showed higher incidence of Rhizopus sp. on the evaluated treatments, and a reduction of Aspergillus sp. and Fusarium sp., while behaviour was influenced by thermotherapy, indicating air and hot water at 50ºC, for 20 min., as an alternative method for post harvest disease control caused by Aspergillus sp. and Fusarium sp. on Spondias fruits.

  2. «Los patíbulos son andamios». Giovanni Battista Piranesi y la técnica edilicia de época romana

    Directory of Open Access Journals (Sweden)

    Pizzo, Antonio

    2011-12-01

    Full Text Available This article focuses on a specific aspect of the work of G.B. Piranesi: the knowledge of the technical engineering elements linked to the Venetian author’s education. His entire works have been studied in order to find the greatest number of references to help to understand Roman building technology filtered by the original shape of the designs on the illustrations. In this sense, several groups of graphic representations have been identified allowing us to establish a connection with the world of construction which is evident in all of the illustrations that deal with older buildings. Our goal is to reevaluate the details in the works of Piranesi which try to penetrate in the anatomy of Roman structures aiming to learn and show «how» they were built.En este artículo se ha prestado atención a un aspecto específico de la obra de G. B. Piranesi: el conocimiento de los elementos técnico-constructivos de la arquitectura romana. Se ha realizado un análisis de la totalidad de su obra, en el intento de encontrar el mayor número posible de referencias útiles para la comprensión de la tecnología edilicia romana, filtrada por la forma original de las composiciones de las láminas. En este sentido, se han identificado varios grupos de representaciones gráficas que nos permiten plantear la presencia de un hilo conductor constante en relación con el mundo de la construcción, evidente en la casi totalidad de láminas que tratan edificios antiguos. El objetivo final es la reevaluación de aquellos detalles de las obras de Piranesi que intentan penetrar en la anatomía de las estructuras romanas para aprender y demostrar las modalidades constructivas.

  3. Changes with time after treatment in the concentrations of ivermectin in fresh cow dung and in cow pats aged in the field

    DEFF Research Database (Denmark)

    Sommer, C; Steffansen, B

    1993-01-01

    An analytical procedure for detection of ivermectin in plasma samples was modified and used for measuring ivermectin concentrations in dung samples. The residues were quantified by high-performance liquid chromatography and fluorescence detection after extraction, purification, and derivatization...

  4. Process analytical technology (PAT) approach to the formulation of thermosensitive protein-loaded pellets: Multi-point monitoring of temperature in a high-shear pelletization.

    Science.gov (United States)

    Kristó, Katalin; Kovács, Orsolya; Kelemen, András; Lajkó, Ferenc; Klivényi, Gábor; Jancsik, Béla; Pintye-Hódi, Klára; Regdon, Géza

    2016-12-01

    In the literature there are some publications about the effect of impeller and chopper speeds on product parameters. However, there is no information about the effect of temperature. Therefore our main aim was the investigation of elevated temperature and temperature distribution during pelletization in a high shear granulator according to process analytical technology. During our experimental work, pellets containing pepsin were formulated with a high-shear granulator. A specially designed chamber (Opulus Ltd.) was used for pelletization. This chamber contained four PyroButton-TH® sensors built in the wall and three PyroDiff® sensors 1, 2 and 3cm from the wall. The sensors were located in three different heights. The impeller and chopper speeds were set on the basis of 3 2 factorial design. The temperature was measured continuously in 7 different points during pelletization and the results were compared with the temperature values measured by the thermal sensor of the high-shear granulator. The optimization parameters were enzyme activity, average size, breaking hardness, surface free energy and aspect ratio. One of the novelties was the application of the specially designed chamber (Opulus Ltd.) for monitoring the temperature continuously in 7 different points during high-shear granulation. The other novelty of this study was the evaluation of the effect of temperature on the properties of pellets containing protein during high-shear pelletization. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Real-time polymerase chain reaction-based approach for quantification of the pat gene in the T25 Zea mays event.

    Science.gov (United States)

    Weighardt, Florian; Barbati, Cristina; Paoletti, Claudia; Querci, Maddalena; Kay, Simon; De Beuckeleer, Marc; Van den Eede, Guy

    2004-01-01

    In Europe, a growing interest for reliable techniques for the quantification of genetically modified component(s) of food matrixes is arising from the need to comply with the European legislative framework on novel food products. Real-time polymerase chain reaction (PCR) is currently the most powerful technique for the quantification of specific nucleic acid sequences. Several real-time PCR methodologies based on different molecular principles have been developed for this purpose. The most frequently used approach in the field of genetically modified organism (GMO) quantification in food or feed samples is based on the 5'-3'-exonuclease activity of Taq DNA polymerase on specific degradation probes (TaqMan principle). A novel approach was developed for the establishment of a TaqMan quantification system assessing GMO contents around the 1% threshold stipulated under European Union (EU) legislation for the labeling of food products. The Zea mays T25 elite event was chosen as a model for the development of the novel GMO quantification approach. The most innovative aspect of the system is represented by the use of sequences cloned in plasmids as reference standards. In the field of GMO quantification, plasmids are an easy to use, cheap, and reliable alternative to Certified Reference Materials (CRMs), which are only available for a few of the GMOs authorized in Europe, have a relatively high production cost, and require further processing to be suitable for analysis. Strengths and weaknesses of the use of novel plasmid-based standards are addressed in detail. In addition, the quantification system was designed to avoid the use of a reference gene (e.g., a single copy, species-specific gene) as normalizer, i.e., to perform a GMO quantification based on an absolute instead of a relative measurement. In fact, experimental evidences show that the use of reference genes adds variability to the measurement system because a second independent real-time PCR-based measurement must be performed. Moreover, for some reference genes no sufficient information on copy number in and among genomes of different lines is available, making adequate quantification difficult. Once developed, the method was subsequently validated according to IUPAC and ISO 5725 guidelines. Thirteen laboratories from 8 EU countries participated in the trial. Eleven laboratories provided results complying with the predefined study requirements. Repeatability (RSDr) values ranged from 8.7 to 15.9%, with a mean value of 12%. Reproducibility (RSDR) values ranged from 16.3 to 25.5%, with a mean value of 21%. Following Codex Alimentarius Committee guidelines, both the limits of detection and quantitation were determined to be <0.1%.

  6. Ne každý podvodník měl patřičnou úroveň

    Czech Academy of Sciences Publication Activity Database

    Altman, Karel

    2015-01-01

    Roč. 51, č. 5 (2015), s. 17 ISSN 0323-1542 Institutional support: RVO:68378076 Keywords : hustler * bastard * court * poor people * police search * Czech lands Subject RIV: AC - Archeology, Anthropology, Ethnology

  7. Glicosilación intestinal y su relación con la interacción hospedero-patógeno.

    Directory of Open Access Journals (Sweden)

    Gregory Ramón Valdés Paneca

    2015-03-01

    Full Text Available Se evaluó el efecto bloqueador de diferentes lectinas vegetales en la adhesión de E. coli enterotoxigénicas que expresan fimbrias F4. Se realizaron dos experimentos. Primero – las vellosidades fueron incubadas con lectinas de Glycine max, Ulex europaeus, Lens culinaris y Arachis hypogaea a diferentes concentraciones y después fueron incubadas con las cepa de E. coli GIS26 (F4ac. Segundo – veinte y seis lectinas vegetales biotiniladas se enfrentaron a las vellosidades bajo 3 métodos de fijación diferentes. La unión se verificó mediante la técnica de inmunofluorescencia. Para el primer caso hubo bloqueo total de la adhesión de la E. coli GIS26 al borde en cepillo por parte de las lectinas; para el segundo caso se mostró que existe una adhesión moderada y fuerte a las células epiteliales intestinales en el 69,2% (18/26 de las lectinas. Al mismo tiempo se probaron la adhesión de lectinas biotiniladas a diferentes regiones del intestino delgado y la unión de los antígenos fimbriales F4ab, F4ac y F4ad al borde en cepillo. Se encontraron variaciones en el perfil de unión de las lectinas a lo largo de las diferentes regiones del intestino delgado y no homogeneidad en la adhesión de los antígenos fimbriales.

  8. Implant Supported Prosthesıs in a Patıent wıth Progerıa: Case Report

    Directory of Open Access Journals (Sweden)

    Gözlem Ceylan

    2009-08-01

    Full Text Available Prosthodontic rehabilitation can be accomplished with fixed, overdenture, complete, or implant-retained prostheses. Dental treatment overcomes the patient’s functional, psychological, esthetic and phonation problems. Remaining healthy teeth may allow the dentist to fabrícate a removable partial overdenture, fixed partial prosthesis or implant - supported prosthesis. The retention of a number of abutments helps maintain a positive ridge form with greater height and volume of the alveolar bone, improving masticatory performance, as well as providing a more stable prostheses. Dental patients who have medical problems need many treatment procedures. Multidisciplinary treatment planning is invaluable for patient’s dental health. Progeria is a rare genetic condition where symptoms resembling aspects of aging are manifested at an early age. characteristic clinical findings of Progeria disease include abnormalities of the skin and hair in conjunction with char-acteristic facial features and skeletal abnormalities. The characteristic facies show protruding ears, beaked nose, thin lips with centrofacial cyanosis, prominent eyes, frontal and parietal bossing with pseudohydrocephaly, midface hypoplasia with micrognathia and large anterior fontanel. The other reported anomalies are dystrophic nails, hypertrophic scars and hypoplastic nipples. The findings that are nearly interested in dentistry are delayed dentition, anodontia, hypodontia, or crowding of teeth. This article presents the multidisciplinary dental treatment planning includes surgical, endodontic and prosthetic treatment of a patient with a history of progeria. In this case complete-arch fixed prostheses in both maxilla and mandible, supported by a combination of im-plants and teeth are reported.

  9. Plan de seguridad y salud en el trabajo: instalación de filtros mejilloneros y P.A.T. Trafos Aboño

    OpenAIRE

    Carpintero Cuesta, Carla

    2013-01-01

    Desarrollo de un plan de seguridad y salud en el trabajo, para una obra de construcción en una central térmica. Los objetivos de este trabajo son: - Garantizar la salud e integridad física de los trabajadores. _ Evitar acciones o situaciones peligrosas por improvisación, insuficiencia o falta de medios. _ Delimitar atribuciones y responsabilidades en materia de seguridad entre las personas que intervienen en el proceso constructivo. _ Determinar los costos de las medidas de protec...

  10. Virus patógenos de culícidos: diversidad, patología, transmisión y espectro hospedador

    OpenAIRE

    Muttis, Evangelina

    2017-01-01

    Es de público conocimiento la importancia cada vez mayor que tienen los mosquitos como vectores de enfermedades del hombre y de los animales domésticos, considerando que las enfermedades transmitidas por ellos representan más del 17% de todas las enfermedades infecciosas y provocan cada año, más de 1 millón de defunciones. Se hace evidente la necesidad de métodos de control de vectores más eficaces que los empleados hasta ahora. Un mayor conocimiento en este sentido, nos ayudará a evaluar nue...

  11. Antimicrobial activity of Uncaria tomentosa against oral human pathogens Atividade antimicrobiana da Uncaria tomentosa sobre patógenos da cavidade bucal humana

    Directory of Open Access Journals (Sweden)

    Renzo Alberto Ccahuana-Vasquez

    2007-03-01

    Full Text Available Uncaria tomentosa is considered a medicinal plant used over centuries by the peruvian population as an alternative treatment for several diseases. Many microorganisms usually inhabit the human oral cavity and under certain conditions can become etiologic agents of diseases. The aim of the present study was to evaluate the antimicrobial activity of different concentrations of Uncaria tomentosa on different strains of microorganisms isolated from the human oral cavity. Micropulverized Uncaria tomentosa was tested in vitro to determine the minimum inhibitory concentration (MIC on selected microbial strains. The tested strains were oral clinical isolates of Streptococcus mutans, Staphylococcus spp., Candida albicans, Enterobacteriaceae and Pseudomonas aeruginosa. The tested concentrations of Uncaria tomentosa ranged from 0.25-5% in Müeller-Hinton agar. Three percent Uncaria tomentosa inhibited 8% of Enterobacteriaceae isolates, 52% of S. mutans and 96% of Staphylococcus spp. The tested concentrations did not present inhibitory effect on P. aeruginosa and C. albicans. It could be concluded that micropulverized Uncaria tomentosa presented antimicrobial activity on Enterobacteriaceae, S. mutans and Staphylococcus spp. isolates.Uncaria tomentosa é uma planta medicinal usada por vários séculos pela população peruana como alternativa de tratamento para diversas doenças. Muitos microrganismos que usualmente não habitam a cavidade bucal humana podem se tornar agentes etiológicos de doenças sob certas condições. O objetivo deste estudo foi avaliar a atividade antimicrobiana de diferentes concentrações de Uncaria tomentosa sobre diferentes cepas de microrganismos isolados de cavidades bucais humanas. Uncaria tomentosa micropulverizada foi testada in vitro para determinar a concentração inibitória mínima (CIM em isolados microbianos selecionados. Cepas de Streptococcus mutans, Staphylococcus spp., Candida albicans, Enterobacteriaceae e Pseudomonas aeruginosa avaliadas foram isoladas de cavidades bucais humanas. Foram preparadas as concentrações de Uncaria tomentosa entre 0.25 e 5% em ágar Müeller-Hinton. Uncaria tomentosa a 3% inibiu 8% de Enterobacteriaceae, 52% de S. mutans e 96% de Staphylococcus spp. As concentrações testadas não apresentaram efeito inibitório sobre P. aeruginosa e C. albicans. Concluiu-se que Uncaria tomentosa micropulverizada apresenta atividade antimicrobiana sobre cepas de Enterobacteriaceae, S. mutans e Staphylococcus spp.

  12. Preparation of Power Distribution System for High Penetration of Renewable Energy Part I. Dynamic Voltage Restorer for Voltage Regulation Pat II. Distribution Circuit Modeling and Validation

    Science.gov (United States)

    Khoshkbar Sadigh, Arash

    Part I: Dynamic Voltage Restorer In the present power grids, voltage sags are recognized as a serious threat and a frequently occurring power-quality problem and have costly consequence such as sensitive loads tripping and production loss. Consequently, the demand for high power quality and voltage stability becomes a pressing issue. Dynamic voltage restorer (DVR), as a custom power device, is more effective and direct solutions for "restoring" the quality of voltage at its load-side terminals when the quality of voltage at its source-side terminals is disturbed. In the first part of this thesis, a DVR configuration with no need of bulky dc link capacitor or energy storage is proposed. This fact causes to reduce the size of the DVR and increase the reliability of the circuit. In addition, the proposed DVR topology is based on high-frequency isolation transformer resulting in the size reduction of transformer. The proposed DVR circuit, which is suitable for both low- and medium-voltage applications, is based on dc-ac converters connected in series to split the main dc link between the inputs of dc-ac converters. This feature makes it possible to use modular dc-ac converters and utilize low-voltage components in these converters whenever it is required to use DVR in medium-voltage application. The proposed configuration is tested under different conditions of load power factor and grid voltage harmonic. It has been shown that proposed DVR can compensate the voltage sag effectively and protect the sensitive loads. Following the proposition of the DVR topology, a fundamental voltage amplitude detection method which is applicable in both single/three-phase systems for DVR applications is proposed. The advantages of proposed method include application in distorted power grid with no need of any low-pass filter, precise and reliable detection, simple computation and implementation without using a phased locked loop and lookup table. The proposed method has been verified by simulation and experimental tests under various conditions considering all possible cases such as different amounts of voltage sag depth (VSD), different amounts of point-on-wave (POW) at which voltage sag occurs, harmonic distortion, line frequency variation, and phase jump (PJ). Furthermore, the ripple amount of fundamental voltage amplitude calculated by the proposed method and its error is analyzed considering the line frequency variation together with harmonic distortion. The best and worst detection time of proposed method were measured 1ms and 8.8ms, respectively. Finally, the proposed method has been compared with other voltage sag detection methods available in literature. Part 2: Power System Modeling for Renewable Energy Integration: As power distribution systems are evolving into more complex networks, electrical engineers have to rely on software tools to perform circuit analysis. There are dozens of powerful software tools available in the market to perform the power system studies. Although their main functions are similar, there are differences in features and formatting structures to suit specific applications. This creates challenges for transferring power system circuit models data (PSCMD) between different software and rebuilding the same circuit in the second software environment. The objective of this part of thesis is to develop a Unified Platform (UP) to facilitate transferring PSCMD among different software packages and relieve the challenges of the circuit model conversion process. UP uses a commonly available spreadsheet file with a defined format, for any home software to write data to and for any destination software to read data from, via a script-based application called PSCMD transfer application. The main considerations in developing the UP are to minimize manual intervention and import a one-line diagram into the destination software or export it from the source software, with all details to allow load flow, short circuit and other analyses. In this study, ETAP, OpenDSS, and GridLab-D are considered, and PSCMD transfer applications written in MATLAB have been developed for each of these to read the circuit model data provided in the UP spreadsheet. In order to test the developed PSCMD transfer applications, circuit model data of a test circuit and a power distribution circuit from Southern California Edison (SCE) - a utility company - both built in CYME, were exported into the spreadsheet file according to the UP format. Thereafter, circuit model data were imported successfully from the spreadsheet files into above mentioned software using the PSCMD transfer applications developed for each software. After the SCE studied circuit is transferred into OpenDSS software using the proposed UP scheme and developed application, it has been studied to investigate the impacts of large-scale solar energy penetration. The main challenge of solar energy integration into power grid is its intermittency (i.e., discontinuity of output power) nature due to cloud shading of photovoltaic panels which depends on weather conditions. In order to conduct this study, OpenDSS time-series simulation feature, which is required due to intermittency of solar energy, is utilized. In this study, the impacts of intermittency of solar energy penetration, especially high-variability points, on voltage fluctuation and operation of capacitor bank and voltage regulator is provided. In addition, the necessity to interpolate and resample unequally spaced time-series measurement data and convert them to equally spaced time-series data as well as the effect of resampling time-interval on the amount of error is discussed. Two applications are developed in Matlab to do interpolation and resampling as well as to calculate the amount of error for different resampling time-intervals to figure out the suitable resampling time-interval. Furthermore, an approach based on cumulative distribution, regarding the length for lines/cables types and the power rating for loads, is presented to prioritize which loads, lines and cables the meters should be installed at to have the most effect on model validation.

  13. Aislamiento y caracterización bioquímica de la α-glucosidasa II del hongo patógeno Candida albicans Aislamiento y caracterización bioquímica de la α-glucosidasa II del hongo patógeno Candida albicans

    Directory of Open Access Journals (Sweden)

    Arturo Flores Carreón

    2012-02-01

    Full Text Available Alpha-glucosidase II participates in N-linked glycosylation of proteins. A soluble 47 kDa α-glucosidase II has been previously isolated from C. albicans; however, bioinformatics analysis indicate that native enzyme has a molecular mass of 100 kDa. In this study we assessed the effect of protease inhibitors on intracellular distribution of α-glucosidase II. Despite there was not a significant change in the enzyme distribution, α-glucosidase II activity was associated to a 83 or 47 kDa polypeptide in absence or presence of inhibitors, respectively. Soluble 83-kDa protein was purified by conventional methodology and its biochemical characteristics were similar to those reported for the 47 kDa enzyme. Thus, these results indicated the 83 kDa protein is an α-glucosidase II and also suggested it is a precursor of the 47 kDa enzyme previously reported. La α-glucosidasa II participa en la ruta de la N-glicosilación de proteínas. En Candida albi­cans se ha aislado un polipéptido soluble de 47 kDa con actividad de α-glucosidasa II; sin embargo, análisis bioinformáticos indican que la enzima nativa pudiera tener un peso mo­lecular de 100 kDa. En este trabajo se estudió el efecto de inhibidores de proteasas sobre la distribución intracelular de la α-glucosidasa II. Se demostró que la distribución intracelular no fue afectada significativamente, pero la actividad de la α-glucosidasa II estuvo asociada a una proteína de 83 ó 47 kDa en ausencia o presencia de inhibidores de proteasas, res­pectivamente. La enzima soluble de 83 kDa se purificó por métodos convencionales y se demostró que presenta características bioquímicas similares a la enzima de 47 kDa. Estos datos confirmaron que la proteína de 83 kDa es una α-glucosidasa II y sugieren que es precursora de la enzima de 47 kDa previamente descrita.

  14. Variación patogénica y fuentes de resistencia a Colletotrichum lindemuthianum Sacc & magn Scrib., patógeno de la antracnosis del frijol, en Colombia Variación patogénica y fuentes de resistencia a Colletotrichum lindemuthianum (Sacc & Magn Scrib., patógeno de la antracnosis del fríjol, en Colombia

    Directory of Open Access Journals (Sweden)

    Cobo S. Felipe

    1987-03-01

    Full Text Available Pathogenic variation studies with colombian isolates of Colletotrichum lindemuthianum (Sacc & Magn Scrib., the anthracnose bean pathogen, were conducted under laboratory and greenhouse conditions at CIAT, Colombia. In addition, bean germplam with cormercial grain color was evaluated with the objective of identifying resistant varieties and sources of resistance to the existing variation. To this purpose, 17 isolates of C. lindemuthianum collected at the principal Colombian bean zones, were inoculated on 21 American and European differential bean varieties.En los laboratorios e invernaderos del programa de fitopatología de fríjol del CIAT, se estudió la variación patogénica de aislamientos colombianos de Colletotrichum lindemuthianum (Sacc& Magn Scrib. También se evaluó germoplasma de frijol con grano de color comercial con el objetivo de identificar líneas resistentes y fuentes de resistencia a la variación existente. Para este fin, 17 aislamientos de C.lindemuthianum, colectados en las principales zonas frijoleras colombianas se inocularon sobre 21 variedades diferenciales.

  15. Cellular Phone Towers, Cell tower locations as derived from various sources including the Department of Licenses and Inspections and the Department of Planning and Zoning., Published in 2010, 1:2400 (1in=200ft) scale, Howard County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Cellular Phone Towers dataset current as of 2010. Cell tower locations as derived from various sources including the Department of Licenses and Inspections and the...

  16. How HANDy Are Baby Signs? A Systematic Review of the Impact of Gestural Communication on Typically Developing, Hearing Infants under the Age of 36 Months: Response to Howard and Doherty-Sneddon's Commentary

    Science.gov (United States)

    Fitzpatrick, Elizabeth M.; Johnston, J. Cyne; Thibert, Jonelle; Grandpierre, Viviane

    2014-01-01

    A systematic review was conducted to synthesize the evidence related to the effectiveness of baby sign language for children with typical development. This response to a Commentary on the review stresses that the primary purpose of the review was to assist caregivers and policy makers with informed decision-making related to the benefits of the…

  17. Proceedings 16th Annual Meeting, Aquatic Plant Control Research Planning and Operations Review Held at St. Paul, Minnesota on 17-19 November 1981.

    Science.gov (United States)

    1982-06-01

    Overview, by Howard E. Westerdahl ............................. 51 Evaluating Controlled Release Herbicides for Aquatic Weed Control, by Thai K. Van...Evaluation of Controlled-Release 2,4-D Formulations in Lake Seminole, Georgia, by Ronald E. Hoeppel and Howard E. Westerdahl ...78 2,4-D Residue Dissipation Studies to Support Expansion of the Federal Label, by Howard E. Westerdahl and Ronald E. Hoeppel

  18. Caracterización fenotípica y transcripcional de mutantes afectados en la N-glicosilación de proteínas en el patógeno Candida albicans

    OpenAIRE

    Cívicos Villa, Carlos

    2014-01-01

    [ES]Candida albicans es un organismo eucariota diploide que presenta reproducción asexual por gemación y un uso de codones diferente al de Saccharomyces cerevisiae (el codón CUG es traducido por serina en lugar de leucina). A pesar de no ser tan sencilla de manipular como S. cerevisiae, se han desarrollado en los últimos años las herramientas que permiten llevar a cabo en C. albicans estudios a nivel de Biología Molecular. Nuestro estudio se centra en mutantes de Candida albicans afectados...

  19. Seroprevalence of HIV, HTLV-I/II and other perinatally-transmitted pathogens in Salvador, Bahia Soroprevalência do HIV, HTLV-I/II e outros patógenos de transmissão perinatal em Salvador, Bahia

    Directory of Open Access Journals (Sweden)

    Jairo Ivo dos Santos

    1995-08-01

    Full Text Available Generation of epidemiological data on perinatally-transmitted infections is a fundamental tool for the formulation of health policies. In Brazil, this information is scarce, particularly in Northeast, the poorest region of the country. In order to gain some insights of the problem we studied the seroprevalence of some perinatally-transmitted infections in 1,024 low income pregnant women in Salvador, Bahia. The prevalences were as follow: HIV-1 (0.10%, HTLV-I/II (0.88%, T.cruzi (2.34%. T.pallidum (3.91%, rubella virus (77.44%. T.gondii IgM (2.87% and IgG (69.34%, HBs Ag (0.6% and anti-HBs (7.62%. Rubella virus and T.gondii IgG antibodies were present in more than two thirds of pregnant women but antibodies against other pathogens were present at much lower rates. We found that the prevalence of HTLV-I/II was nine times higher than that found for HIV-1. In some cases such as T.cruzi and hepatitis B infection there was a decrease in the prevalence over the years. On the other hand, there was an increase in the seroprevalence of T.gondii infection. Our data strongly recommend mandatory screening tests for HTLV-I/II, T.gondii (IgM, T.pallidum and rubella virus in prenatal routine for pregnant women in Salvador. Screening test for T.cruzi, hepatitis and HIV-1 is recommended whenever risk factors associated with these infections are suspected. However in areas with high prevalence for these infections, the mandatory screening test in prenatal care should be considered.A obtenção de dados epidemiológicos é de fundamental importância para o estabelecimento de políticas em Saúde Pública. No Brasil, essas informações são escassas, principalmente na região Nordeste. Para se obter alguns destes dados, avaliamos a soroprevalência de algumas infecções de transmissão perinatal, em cerca de 1024 gestantes de baixa renda, em Salvador, Bahia. Os resultados encontrados foram os seguintes: HIV-1 (0,10%, HTLV-I/II (0,88%, T.cruzi (2,34%, T.pallidum (3,91%, vírus da rubéola (77,44%, IgM e IgG para T.gondii (2,87% e 69,34%, respectivamente, e antígenos e anticorpos de superfície (HBs Ag e anti-HBs do vírus da hepatite B (0,6% e 7,62%, respectivamente. A prevalência de HTLV-I/II foi nove vezes maior do que aquela observada para o HIV-1. Constatou-se um decréscimo na prevalência das infecções causadas pelos T.cruzi e o vírus da hepatite B, em relação a anos anteriores, enquanto na infecção pelo T.gondii houve um aumento. Em função dos dados encontrados recomendamos que em Salvador, testes de triagem para HTLV-I, IgM, para T.gondii, T.pallidum e o vírus da rubéola, sejam feitos como rotina prenatal, e que triagens para T.cruzi, hepatite B e HIV-1 sejam feitas quando estiverem presentes fatores de risco associados a estas infecções. Entretanto, em áreas com altas taxas de prevalência para estas infecções, a triagem no prenatal deve ser considerada.

  20. Influencia del campo magnético sobre el crecimiento de microorganismos patógenos ambientales aislados en el Archivo Nacional de la República de Cuba

    Directory of Open Access Journals (Sweden)

    Matilde Anaya

    2015-09-01

    Conclusión. Se concluyó que el campo magnético aplicado tuvo un efecto estimulante sobre los microorganismos estudiados, lo cual potencia el riesgo para la salud del personal y los visitantes del Archivo Nacional de la República de Cuba.

  1. El medio de Kaminski adicionado con nistatina para el aislamiento de dermatofitos y otros hongos patógenos Modified Kaminski agar for the isolation of dermatophytes and some other pathogenic fungi

    Directory of Open Access Journals (Sweden)

    Fernando Montoya

    1989-01-01

    Full Text Available

    Se evaluaron 3 medios de cultivo de composición diferente (Mycobiotic agar, agar de Kaminski y agar de Kaminski adicionado con nistatina para el aislamiento de dermatofitos y el reaislamiento de S. schenckii y hongos negros, agentes de cromomicosis. Con el objeto de puntualizar diferencias entre dichos medios se determinaron, para cada uno, la frecuencia de aislamiento de los hongos, sus características morfológicas y su tiempo de crecimiento, así como la rapidez e Intensidad de la contaminación bacteriana y/o micótica. Se estudiaron 150 muestras de pacientes con sospecha clínica de dermatofitosis y se hicieron 30 reaislamientos de S. schenckiiy 10 de agentes de cromomicosis. Se demostró la utilidad del agar de Kaminski modificado, tanto para el aislamiento como para el reaislamiento de los agentes señalados, a pesar de su mayor índice de contaminación microbiana. Fue, además, útil para el aislamiento de levaduras del género Candida.

    Three culture media with different composition (Mycobiotic agar, Kaminski agarand Kaminski agar modified with nystatin were evaluated for isolation of dermatophytes and reisolation of S. schenckiiand dematiaceous fungi. One hundred and fifty specimens of cases suspicious of dermatophytosis, as well as 30 strains of S. schenckiiand 10 of chromoblatomycosis agents were studied. The modified Kaminski agar was efficient for the isolation and reisolation of the tested agents, in spite of Its greater contamination rate; It was equally adequate for isolation of Candida species.

  2. Assessment of sewage water as carrier of pathogenic organisms to cattle/ Ensaio com águas poluídas como veiculadoras de patógenos para bovinos

    Directory of Open Access Journals (Sweden)

    Valdair Josino Carvalho Landin

    2001-08-01

    Full Text Available Water of a brook that receives raw sewage from Jaboticabal, São Paulo State tawn, that passes through the grounds of the UNESP University campus, and, of the well that provides water to the University’s facilities were submitted to bacteriological and parasitological analysis. At the same time, 16 steers aged 8 to 16 months (8 Bos indicus and 8 Bos taurus, were closed in and given one of each type of water to drink (4 to each water source for seven fifteen day periods. On day zero all the animals were treated with ivermectin (at a dosage of 200 mg/Kg and were randomly separated in two groups (one for each water source. The experimental cattle came from farms supposedly free of cysticercosis and underwent clinical and laboratorial testing to detect the presence of this parasite before the beginning and at regular intervals during the experiment. After the seven fifteen day period, the 16 steers were slaughtered and were inspected by the “Serviço de Inspeção Federal – SIF” (Federal Inspection Service. Blood and tissue samples were taken from all animals for laboratorial testing. a the bacteriological tests revealed that the water from the well, classified as drinking water, had fecal coliform levels compatible to the classification as “drinking water” (CONAMA 20, but the water from the brook “Cerradinho” was classified as polluted in all samples; b the samples taken during the 15 weeks all showed the presence of eggs of Cestode ( Taenia and Hymenolepis and Nematode ( Ascaris, Trichuris, Capillaria and Ancylostomidae helminthes; c while one of eight steers given drinking water from the well was infected with Cysticercus bovis, four of the eight that drank water from the Cerradinho brook were infected; d although the parasitological tests showed the presence of helminth eggs of Taenia genus, the finding of one animal with positive serum and another with the parasite embedded in its muscle, both from the group that drank the well water, suggest that theses animals were infected at the farm before the beginning of the experiment; e the serological tests were negative for Leptospira spp, Brucella spp, Neospora canimum and Toxoplasma gondii, indicating that these pathogens were not transmitted to the animals. Laboratorial tests with mice, to verify the presence of Toxoplasma gondii, confirmed the serological tests; f the results obtained by the serology tests and those of the Federal Inspection Service showed only 6.25% of agreement.Águas de um córrego que recebe efluentes de esgotos urbanos da cidade de Jaboticabal, SP que passa dentro da área do Campus, e de um poço artesiano que abastece o Campus da UNESP foram submetidas a análises bacteriológicas e parasitológicas. Paralelamente a essas provas, 16 bovinos com 8 a 16 meses de idade (8 Bos indicus e 8 Bos taurus foram confinados e dessedentados (4 com cada fonte d’água por sete quinzenas. No dia zero, todos os animais receberam uma dose de ivermectina (200 mg/Kg de peso corpóreo e foram randomizados. Esses animais provieram de propriedades supostamente livres de cisticercose e foram submetidos a exames clínicolaboratoriais, antes e periodicamente, a intervalos regulares. Findas as sete quinzenas, os 16 bovinos foram abatidos e submetidos ao Serviço de Inspeção Federal (SIF. Desses animais foram colhidas amostras de sangue e tecidos para as provas laboratoriais: a as provas bacteriológicas revelaram que enquanto a fonte de água “potável” apresentou teores de coliformes fecais compatíveis à classificação de água potável (resolução CONAMA 20, as águas do córrego Cerradinho sempre obtiveram a classificação de poluída; b ao longo das 15 semanas as águas do córrego Cerradinho apresentaram ovos de Cestoda ( Taenia e Hymenolepis e de Nematoda ( Ascaris, Trichuris, Capillaria e Ancylostomidae; c enquanto um de oito bovinos dessedentados com água potável apresentou-se infectado por Cysticercus bovis, quatro dos oito que beberam água do córrego Cerradinho mostraram-se positivos; d embora as análises parasitológicas mostrem que as águas do córrego estejam carreando ovos do gênero Taenia, a presença de um animal soropositivo e de outro com Cysticercus bovis na musculatura, ambos do grupo que recebeu água potável, sugerem infecção desses animais na propriedade de origem; e os testes sorológicos não evidenciaram transmissão de Leptospira spp, Brucella spp, Neospora caninum ou de Toxoplasma gondii aos bovinos e, a bioprova conduzida em camundongos, objetivando o diagnóstico de T. gondii, confirmou o resultado sorológico; f os resultados obtidos pelos exames sorológicos e pelos critérios do Serviço de Inspeção Federal apresentaram apenas 6,25% de reciprocidade de diagnósticos.

  3. Revisión: spongospora subterranea f.sp. subterranea y su virus asociado potato mop-top virus (pmtv), dos patógenos reemergentes en los cultivos de papa de colombia

    OpenAIRE

    Osorio Giraldo, Inés; Gutiérrez, Pablo Andrés; Marín Montoya, Mauricio

    2012-01-01

    Resumen. El cultivo de papa es uno de los renglones agrícolas de mayor importancia en Colombia; se extiende a 128.701 ha y genera una producción anual de 2,3 millones de t año-1. Desde el punto vista fitosanitario, la papa se ve afectada por diversos problemas, destacándose en los últimos años la reemergencia de la sarna polvosa causada por el protozoario del suelo Spongospora subterranea f.sp. subterranea (Sss). El efecto de esta enfermedad se refleja en el deterioro de la calidad del tubérc...

  4. mRNA Expression of EgCHI1, EgCHI2, and EgCHI3 in Oil Palm Leaves (Elaeis guineesis Jacq. after Treatment with Ganoderma boninense Pat. and Trichoderma harzianum Rifai

    Directory of Open Access Journals (Sweden)

    Laila Naher

    2012-01-01

    Full Text Available Background. Basal stem rot (BSR disease caused by the fungus Ganoderma boninense is the most serious disease affecting the oil palm; this is because the disease escapes the early disease detection. The biocontrol agent Trichoderma harzianum can protect the disease only at the early stage of the disease. In the present study, the expression levels of three oil palm (Elaeis guineensis Jacq. chitinases encoding EgCHI1, EgCHI2, and EgCHI3 at 2, 5, and 8 weeks inoculation were measured in oil palm leaves from plants treated with G. boninense or T. harzianum alone or both. Methods. The five-month-old oil palm seedlings were treated with Gano-wood blocks inoculum and trichomulch. Expression of EgCHI1, EgCHI2, and EgCHI3 in treated leaves tissue was determined by real-time PCR. Results. Oil palm chitinases were not strongly expressed in oil palm leaves of plants treated with G. boninense alone compared to other treatments. Throughout the 8-week experiment, expression of EgCHI1 increased more than 3-fold in leaves of plants treated with T. harzianum and G. boninense when compared to those of control and other treated plants. Conclusion. The data illustrated that chitinase cDNA expression varied depending on tissue and the type of treatment.

  5. mRNA expression of EgCHI1, EgCHI2, and EgCHI3 in oil palm leaves (Elaeis guineesis Jacq.) after treatment with Ganoderma boninense pat. and Trichoderma harzianum Rifai.

    Science.gov (United States)

    Naher, Laila; Tan, Soon Guan; Ho, Chai Ling; Yusuf, Umi Kalsom; Ahmad, Siti Hazar; Abdullah, Faridah

    2012-01-01

    Basal stem rot (BSR) disease caused by the fungus Ganoderma boninense is the most serious disease affecting the oil palm; this is because the disease escapes the early disease detection. The biocontrol agent Trichoderma harzianum can protect the disease only at the early stage of the disease. In the present study, the expression levels of three oil palm (Elaeis guineensis Jacq.) chitinases encoding EgCHI1, EgCHI2, and EgCHI3 at 2, 5, and 8 weeks inoculation were measured in oil palm leaves from plants treated with G. boninense or T. harzianum alone or both. The five-month-old oil palm seedlings were treated with Gano-wood blocks inoculum and trichomulch. Expression of EgCHI1, EgCHI2, and EgCHI3 in treated leaves tissue was determined by real-time PCR. Oil palm chitinases were not strongly expressed in oil palm leaves of plants treated with G. boninense alone compared to other treatments. Throughout the 8-week experiment, expression of EgCHI1 increased more than 3-fold in leaves of plants treated with T. harzianum and G. boninense when compared to those of control and other treated plants. The data illustrated that chitinase cDNA expression varied depending on tissue and the type of treatment.

  6. Determinación de anticuerpos contra patógenos virales y bacterianos seleccionados en la población de cerdos silvestres (Sus scrofa) de la Reserva Natural Bahía Samborombón, Argentina

    OpenAIRE

    B. Carpinetti; G. Castresana; P. Rojas; J. Grant; A. Marcos; M. Monterubbianesi; H. R. Sanguinetti; M. S. Serena; M. G. Echeverría; M. Garciarena; A. Aleksa

    2017-01-01

    Los cerdos silvestres (Sus scrofa) descienden de cruzamientos entre cerdos domésticos liberados durante la colonización con jabalíes salvajes euroasiáticos, liberados con propósitos cinegéticos. Son invasivos y su coexistencia con especies domésticas implica riesgos sanitarios. Argentina es considerada libre de fiebre aftosa (FA), peste porcina clásica (PPC) y africana (PPA) y síndrome reproductivo y respiratorio porcino (PRRS). La enfermedad de Aujeszky (EA) y la leptospirosis son endémic...

  7. A case of acute diarrhea due to the emerging pathogen Campylobacter jejuni subsp. doylei in Southern Chile Um caso de diarréia aguda devido ao patógeno emergente Campylobacter jejuni subsp. doylei no sul do Chile

    Directory of Open Access Journals (Sweden)

    Heriberto Fernández

    2003-04-01

    Full Text Available The first documented case of acute diarrhea due to C. jejuni subsp. doylei in Chile is reported. The clinical findings, the absence of other enteropathogens, virus or parasites and the fact that C. jejuni subsp. doylei was the only bacteria isolated support the assumption that it was the etiological agent of this diarrheal case.O primeiro caso documentado de diarréia aguda por C. jejuni subsp. doylei no sul do Chile é apresentado. As características clínicas, a ausência de outros enteropatógenos, vírus ou parasitas, e o fato de C. jejuni subsp. doylei ter sido a única bactéria isolada, permitem assumir que este microrganismo é o agente etiológico neste caso de diarréia.

  8. Determinación de anticuerpos contra patógenos virales y bacterianos seleccionados en la población de cerdos silvestres (Sus scrofa de la Reserva Natural Bahía Samborombón, Argentina

    Directory of Open Access Journals (Sweden)

    B. Carpinetti

    2017-06-01

    Full Text Available Los cerdos silvestres (Sus scrofa descienden de cruzamientos entre cerdos domésticos liberados durante la colonización con jabalíes salvajes euroasiáticos, liberados con propósitos cinegéticos. Son invasivos y su coexistencia con especies domésticas implica riesgos sanitarios. Argentina es considerada libre de fiebre aftosa (FA, peste porcina clásica (PPC y africana (PPA y síndrome reproductivo y respiratorio porcino (PRRS. La enfermedad de Aujeszky (EA y la leptospirosis son endémicas en ciertas áreas del país. El objetivo fue evaluar la presencia de ciertas enfermedades zoonóticas y/o de importancia para la producción animal y la conservación de la biodiversidad en cerdos silvestres de la Bahía de Samborombón. Se capturaron 118 animales. Se tomaron muestras de suero, tonsilas, músculo, intestino delgado, linfonódulos, entre otras. Se estudió la presencia de anticuerpos contra Brucella spp., coronavirus respiratorio porcino, virus de la estomatitis vesicular, de la FA, de la gastroenteritis transmisible porcina (TGEV, de la PPC, PPA, EA, PRRS y Leptospira spp. Se realizaron análisis bacteriológicos para Mycobacterium spp. Los resultados ratificaron la ausencia de las enfermedades exóticas e indicaron que 36 % de los animales presentó anticuerpos contra Leptospira interrogans serovar pomona y 62,5 % contra el virus de la EA. Estos resultados remarcan la importancia del monitoreo de la interfase productiva/silvestre en función de la salud pública, producción animal y conservación de la biodiversidad.

  9. Identificação laboratorial dos patógenos oculares mais freqüentes e sua suscetibilidade in vitro aos agentes antimicrobianos Laboratory identification of the most frequent ocular pathogens and their in vitro sensitivity to antibiotics

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    Eliane Uesugui

    2002-06-01

    Full Text Available Objetivo: Estabelecer os agentes mais comumente isolados nas ceratites, conjuntivites e endoftalmites no Laboratório de Microbiologia da Santa Casa de Misericórdia de São Paulo, assim como determinar o perfil de sensibilidade destes agentes aos antibióticos. Métodos: Realizamos estudo retrospectivo analisando todos os prontuários oftalmológicos do banco de dados do Laboratório de Microbiologia da Santa Casa de São Paulo. Foram coletados os dados de todos os pacientes submetidos à colheita de material ocular nos últimos 5 anos (1994-1999. Selecionamos para o estudo apenas os pacientes com diagnóstico clínico de conjuntivite, ceratite e endoftalmite. Os respectivos antibiogramas foram realizados e somente dados de antibiótico com aplicação em oftalmologia foram analisados. Resultados: Dos 568 casos pesquisados, foram encontrados 282 casos de ceratite bacteriana (49,6%, 214 de conjuntivites (37,7%, 72 de endoftalmites (12,7%. Obtivemos cultura negativa em 333 casos (58,9%. O agente mais freqüentemente isolado foi S. aureus (73 casos; 31,0%. Nas conjuntivites, o segundo agente mais freqüente foi Candida sp (6,6% e 38,3% das culturas foram negativas. Nas ceratites, Pseudomonas aeruginosa apresentou 3,9% de positividade. Nas endoftalmites, nas quais houve apenas 32% de positividade, o segundo agente mais freqüente foi o S. pneumoniae (4,2%. Conclusão: Culturas negativas foram achado mais freqüente. Quando nos deparamos com uma infecção ocular, as chances de o causador ser S. aureus são muito grandes, portanto antes mesmo de se obter o resultado da cultura, tratamento que inclua S. aureus pode ser indicado.Purpose: To establish the most frequently isolated agents in keratitis, conjunctivitis and endophthalmitis by the Laboratory of Microbiology/ Santa Casa of São Paulo, and to determine their antimicrobial sensitivity. Methods: A retrospective study including all ophthalmologic charts of the Laboratory of Microbiology/ Santa Casa of São Paulo was conducted. All ocular material collected during the last five years was analyzed. We included in this study only patients whose diagnoses were conjunctivitis, keratitis and endophthalmitis. Susceptibility tests of drugs with ophthalmological application were analyzed. Results: In a total of 568 cases, we found 282 of bacterial keratitis (49.6%, 214 of conjunctivitis (37.7% and 72 of endophthalmitis (12.7%; three hundred thirty-three negative culture cases were found (58.9%. S. aureus was the most frequently isolated agent (n=73; 31.0%. Conjunctivitis showed Candida sp in 6.6% of all cases, and 38.3% of the cultures were negative. When the diagnosis was keratitis, P. aeruginosa was positive in 3.9% and 71.6% of the cultures were negative. Endophthalmitis showed only 32% of positivity. Conclusion: Inconclusive cultures were the majority. Facing an ocular infection, there is a considerable chance to find S. aureus.

  10. Respuesta inadecuada a los patógenos y otros agresores: ¿deficiencia de Vitamina A? Is inadequate response to pathogens and other aggressors due to vitamin A deficiency?

    Directory of Open Access Journals (Sweden)

    Leal Esteban, Lucía Carolina

    2010-12-01

    Full Text Available La vitamina A desempeña un papel fundamental en el desarrollo de los tejidos y órganos gracias a su capacidad de promover la diferenciación celular y regular la apoptosis. Específicamente en el sistema inmune, esta vitamina tiene efectos muy importantes sobre componentes específicos tanto de la respuesta inmune innata como de la adaptativa. En la inmunidad innata, el ácido retinoico (AR participa en la regeneración de las mucosas y epitelios, promueve la diferenciación de células como los neutrófilos y eosinófilos y potencia la fagocitosis. Además, ayuda a la migración de las diferentes células inmunes promoviendo la producción de metaloproteinasas de matriz extracelular. Aunque sus efectos en las células NK son más controversiales, se ha encontrado que el número y la función lítica de estas células disminuyen cuando hay deficiencia de vitamina A (DVA. Por otra parte, el AR influencia el desarrollo de la inmunidad adaptativa alterando el perfil de producción de citoquinas por parte de las células presentadoras de antígeno, lo que influye en la diferenciación de los linfocitos T ayudadores. En general, se ha observado que el AR amplifica la proliferación de las células T y potencia el desarrollo de células plasmáticas a partir de los linfocitos B maduros. Todos estos efectos tienen repercusiones importantes en la adecuada defensa contra las infecciones, especialmente en la infancia en la cual la DVA es un problema importante de salud pública, no solo en Colombia sino también en aproximadamente otros 60 países.

  11. Análisis y comparación de los glucosinolatos presentes en diferentes accesiones de cubio (Tropaeolum tuberosum) para evaluar su uso potencial en el control del patógeno de la papa Spongospora subterranea

    OpenAIRE

    Arias Cortes, María Mercedes

    2011-01-01

    Se realizó un análisis comparativo del contenido de glucosinolatos totales de 65 accesiones de cubio (Tropaeolum tuberosum) pertenecientes a la Colección Regional de la Facultad de Agronomía de la Universidad Nacional de Colombia, sede Bogotá. Estos fueron evaluados en su forma intacta, inicialmente por cromatografía en capa fina, estableciéndose que los extractos presentan perfiles de composición similares con al menos dos compuestos del tipo glucosinolato. Con base en éstos, se determinó en...

  12. Rozhovor s Pavlem Baranem: Pokud nic nevysoutěžíme je to naše chyba. Společnosti musíme vracet co jí patří

    Czech Academy of Sciences Publication Activity Database

    Boháček, Kryštof

    2009-01-01

    Roč. 1, č. 2 (2009), s. 15-35 ISSN 1803-7860 Institutional research plan: CEZ:AV0Z90090514 Keywords : political philosophy * academic politics * Institute of Philosophy of the Academy of Sciences of the Czech Republic Subject RIV: AA - Philosophy ; Religion

  13. Estudio de patógenos implicados en enfermedades de transmisión sexual: Sensibilidad antibiótica. Genotipado y detección de cepas de linfogranuloma venéreo

    OpenAIRE

    Maulide Cane, Réka

    2014-01-01

    Trabajo fin de máster en Medicina Tropical y Salud Internacional Objetivo: El objetivo principal del presente trabajo es el estudio del porcentaje de casos de infección por Chamydia trachomatis (C. trachomatis), Neisseria gonorrhoeae (N. gonorrhoeae), Mycoplasma hominis (Mycoplasma hominis) y Ureaplasma urealyticum (U. urealyticum) y la determinación de la resistencia antibiótica a N. gonorrhoeae en muestras de pacientes que acudieron a consultas de la Fundación Jiménez Díaz durante el per...

  14. Efecto del secado de los biosólidos de la planta de tratamiento de aguas residuales El Salitre (Bogotá sobre su contenido de nutrientes, metales pesados y patógenos

    Directory of Open Access Journals (Sweden)

    Giraldo Óscar

    2006-12-01

    Full Text Available

    Se acondicionó el biosólido proveniente  de la planta de tratamiento de aguas residuales El Salitre, en Bogotá, para su uso agrícola o forestal, de tal manera que el producto obtenido se encontrara dentro de los límites máximos permisibles de contaminantes establecidos por la estadounidense Environmental Protection Agency (EPA y su contenido de nutrientes se afectara en la menor proporción posible. Se realizaron tratamientos térmicos a temperaturas de 50, 55, 60, 65 y 70 °C, y se determinó el contenido de coliformes totales, E. coli y Salmonella, el contenido de nutrientes totales (N, P, K y metales pesados disponibles (Cd, Cr, Cu, Mn, Ni, Pb, Zn, antes y después de cada uno de los tratamientos. Los tratamientos de secado entre 55-70 °C redujeron los coliformes totales y E. coli hasta niveles apropiados para que el biosólido pueda ser utilizado en aplicaciones forestales. Aunque los contenidos de nutrientes del producto se redujeron entre 75% y 95%, aún se considera apropiados para su utilización como fertilizante. Los metales Cu y Zn aumentaron sus contenidos disponibles después de los tratamientos, Cd y Cr no fueron detectados y los contenidos de  algunos metales pesados (Mn, Ni, Pb se redujeron con el proceso de secado. Sin embargo, para  todos  los metales los valores se encontraron por debajo de los límites establecidos por la EPA para la aplicación del biosólido en terrenos agrícolas. Se concluyó que el tratamiento de secado de biosólido puede considerarse como una opción válida para su acondicionamiento para uso forestal.

  15. O modálních predikativech slovesného původu typu To přende, (se) patří... zbórat

    Czech Academy of Sciences Publication Activity Database

    Šipková, Milena

    2017-01-01

    Roč. 100, č. 4 (2017), s. 265-271 ISSN 0027-8203 R&D Projects: GA ČR(CZ) GA16-04648S Keywords : dialect * verbal modal predicatives * modal verbs * modalization * Dictionary of Czech Dialects Subject RIV: AI - Linguistics OBOR OECD: Linguistics

  16. The ex-pat effect: presence of recent Western immigrants is associated with changes in age at first birth and birth rate in a Maya population from rural Guatemala.

    Science.gov (United States)

    McKerracher, Luseadra; Collard, Mark; Altman, Rachel; Richards, Michael; Nepomnaschy, Pablo

    2017-08-01

    Economic transitions expose indigenous populations to a variety of ecological and cultural challenges, especially regarding diet and stress. These kinds of challenges are predicted by evolutionary ecological theory to have fitness consequences (differential reproduction) and, indeed, are often associated with changes in fertility dynamics. It is currently unclear whether international immigration might impact the nature of such an economic transition or its consequences for fertility. To examine measures of fertility, diet and stress in two economically transitioning Maya villages in Guatemala that have been differentially exposed to immigration by Westerners. This study compared Maya women's ages at first birth and birth rates between villages and investigated whether these fertility indicators changed through time. It also explored whether the villages differed in relation to diet and/or a proxy of stress. It was found that, in the village directly impacted by immigration, first births occurred earlier, but birth rate was slower. In both villages, over the sampled time window, age at first birth increased, while birth rate decreased. The villages do not differ significantly in dietary indicators, but the immigration-affected village scored higher on the stress proxy. Immigration can affect fertility in host communities. This relationship between immigration and fertility dynamics may be partly attributable to stress, but this possibility should be evaluated prospectively in future research.

  17. Uso de sustancias antimicrobianas naturales en combinación con compuestos estabilizadores de la calidad para controlar microorganismos patógenos y extender la vida útil de las frutas frescas cortadas

    OpenAIRE

    Raybaudi Massilia, Rosa M.

    2007-01-01

    El consum de fruites fresques tallades i sucs de fruites no pasteuritzats s'haincrementat significativament en els darrers anys degut a la creixent demanda deproductes sans de baix contingut calòric i característiques similars a les del productefresc. Tot i això, aquests productes poden contaminar-se amb microorganismespatògens o deterioratius per una inadequada manipulació o emmagatzematge, donantlloc a riscs de malalties microbianes i deteriorament del producte. De fet, el nombrede brots i ...

  18. Estudio de la interacción entre el hongo formado de micorrizas arbusculares "Glomus intraradices" Schenck y Smith y el hongo patógeno "Armillaria mellea (Vahl:fr)" P.Kuhn en vid

    OpenAIRE

    Nogales García, Amaia Miren

    2009-01-01

    El síndrome de replante es consecuencia de una explotación continua y repetida del terreno en el que los problemas de estrés, principalmente de origen patogénico, juegan un papel importante. En los viñedos españoles, el hongo Armillaria mellea que produce la podredumbre blanca de raíz, está considerado como una de sus principales causas. Existen pocas medidas de control disponibles, puesto que no hay portainjertos comerciales que confieran resistencia frente a A. mellea, y la fumigación del s...

  19. A new case of Beckwith-Wiedemann syndrome with an 11p15 duplication of paternal origin [46,XY,-21,+der(21), t(11;21)(p15.2;q22.3)pat].

    Science.gov (United States)

    Krajewska-Walasek, M; Gutkowska, A; Mospinek-Krasnopolska, M; Chrzanowska, K

    1996-01-01

    We present a new case of 11p15 duplication (trisomy 11p15) in a boy (46,XY,-21,+der(21), t(11;21)(p15.2;q22.3)] suffering from Beckwith-Wiedemann syndrome (BWS), whose phenotypically normal father carries a balanced translocation between chromosomes 11 and 21[46,XY, t(11;21)(p15.2;q22.3)]. The paternal grandmother has the same balanced translocation and is also clinically normal. BWS was suspected when the boy was 6 months old because of gigantism, macroglossia, visceromegaly, ear lobe creases and abdominal distention. Apart from the characteristic BWS phenotype, the boy has other features which are almost exclusively observed in 11p trisomy (high forehead with frontal upsweep of hair, wide central nose bridge, slightly beaked nose, chubby cheeks and severe mental retardation). So far, at least eight cases of 11p15 duplication have been described as patients with BWS. In six of these, the duplication was due to inheritance of a translocated or rearranged paternal chromosome. This was also the case in our patient. In the two other previously published cases, the 11p15 duplications were de novo, but in one of these, DNA analysis has subsequently shown that the duplication was of paternal origin. We discuss our observations in relation to the above-mentioned previous cases of 11p15 duplication and the possible role of genomic imprinting in the etiology of BWS.

  20. Opfølgning på bistand til risikovurdering. Fem forskellige afgrøder. Bt-resistens: oplysninger om Cry-type og pat-gen. Modtaget 22-07-2004, svar 09-08-2004

    DEFF Research Database (Denmark)

    Kjellsson, Gøsta

    2012-01-01

    "Mail: Vi har nu set det eftersendte materiale igennem for B-notifikationerne: B/SE/04/6371 (Resume 2004-3), B/ES/04/11 (Resume 2004-13), B/ES/04/13 (Resume 2004-18), B/ES/04/15 (Resume 2004-14) og B/ES/04/16 (Resume 2004-18) De nye fortrolige oplysninger giver ikke anledning til nogen ændringer ...