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Sample records for hopf cyclic cohomology

  1. Twisted Cyclic Cohomology and Modular Fredholm Modules

    Directory of Open Access Journals (Sweden)

    Adam Rennie

    2013-07-01

    Full Text Available Connes and Cuntz showed in [Comm. Math. Phys. 114 (1988, 515-526] that suitable cyclic cocycles can be represented as Chern characters of finitely summable semifinite Fredholm modules. We show an analogous result in twisted cyclic cohomology using Chern characters of modular Fredholm modules. We present examples of modular Fredholm modules arising from Podleś spheres and from SU_q(2.

  2. Cyclic cohomology and characteristic classes for foliations

    NARCIS (Netherlands)

    Crainic, M.

    2000-01-01

    This thesis deals with the cohomology theories and the theory of characteristic classes for leaf spaces of foliations, as well as with the interaction between the classical approach (of Grothendieck, Bott-Haefliger) and the non-commutative approach (of Connes-Moscovici) to these theories.

  3. Cohomology of Effect Algebras

    Directory of Open Access Journals (Sweden)

    Frank Roumen

    2017-01-01

    Full Text Available We will define two ways to assign cohomology groups to effect algebras, which occur in the algebraic study of quantum logic. The first way is based on Connes' cyclic cohomology. The resulting cohomology groups are related to the state space of the effect algebra, and can be computed using variations on the Kunneth and Mayer-Vietoris sequences. The second way involves a chain complex of ordered abelian groups, and gives rise to a cohomological characterization of state extensions on effect algebras. This has applications to no-go theorems in quantum foundations, such as Bell's theorem.

  4. A generalization of Connes-Kreimer Hopf algebra

    Science.gov (United States)

    Byun, Jungyoon

    2005-07-01

    "Bonsai" Hopf algebras, introduced here, are generalizations of Connes-Kreimer Hopf algebras, which are motivated by Feynman diagrams and renormalization. We show that we can find operad structure on the set of bonsais. We introduce a new differential on these bonsai Hopf algebras, which is inspired by the tree differential. The cohomologies of these are computed here, and the relationship of this differential with the appending operation * of Connes-Kreimer Hopf algebras is investigated.

  5. Galois cohomology

    CERN Document Server

    Serre, Jean-Pierre

    1997-01-01

    This volume is an English translation of "Cohomologie Galoisienne" . The original edition (Springer LN5, 1964) was based on the notes, written with the help of Michel Raynaud, of a course I gave at the College de France in 1962-1963. In the present edition there are numerous additions and one suppression: Verdier's text on the duality of profinite groups. The most important addition is the photographic reproduction of R. Steinberg's "Regular elements of semisimple algebraic groups", Publ. Math. LH.E.S., 1965. I am very grateful to him, and to LH.E.S., for having authorized this reproduction. Other additions include: - A proof of the Golod-Shafarevich inequality (Chap. I, App. 2). - The "resume de cours" of my 1991-1992 lectures at the College de France on Galois cohomology of k(T) (Chap. II, App.). - The "resume de cours" of my 1990-1991 lectures at the College de France on Galois cohomology of semisimple groups, and its relation with abelian cohomology, especially in dimension 3 (Chap. III, App. 2). The bibl...

  6. Comparison of sheaf cohomology and singular cohomology

    OpenAIRE

    Sella, Yehonatan

    2016-01-01

    A classic result states that on any locally contractible and paracompact topological space, singular cohomology and sheaf cohomology are isomorphic. A result by Ramanan claims that the paracompactness assumption may be removed, but Ramanan's proof in fact implicitly relies on the assumption of paracompactness and does not work in the stated generality. This paper gives a modified proof that, in fact, singular cohomology and sheaf cohomology agree on any locally contractible topological space.

  7. Page 1 Bredon cohomology of G-cyclic sets 157 … → H.(k[X]:2 ...

    Indian Academy of Sciences (India)

    C(k[Y]), 2, Then for a G-cyclic set X, we have a chain complex Tot C(k[X]). [2, 0], in Veca defined as before. Note that there is a split short exact sequence of complexes in Vecc. 0–Tot C(k[X]) →Tot C(k[X]). — Tot C(k[X]) [2,0]. - 0. Applying Hom(–, A) we get ashort exact sequence of cochain complexes of k-modules.

  8. Exercises in equivariant cohomology

    CERN Document Server

    Stora, R.

    1996-01-01

    Equivariant cohomology is a mathematical framework particularly well adapted to a kinematical understanding of topological gauge theories of the cohomological type. It also sheds some light on gauge fixing, a necessary field theory operation connected with the non compactness of the gauge group. The respective roles of fields and observables are emphasized throughout.

  9. Exercises in equivariant cohomology

    Energy Technology Data Exchange (ETDEWEB)

    Stora, R. [Grenoble-1 Univ., 74 - Annecy (France). Lab. de Physique des Particules Elementaires]|[European Organization for Nuclear Research (CERN), Geneva (Switzerland). Accelerator School

    1996-12-31

    Equivariant cohomology is a mathematical framework particularly well adapted to a kinematical understanding of topological gauge theories of the cohomological type. It also sheds some light on gauge fixing, a necessary field theory operation connected with the on compactness of the gauge group. The respective roles of fields and observables are emphasized throughout. (author). 17 refs:.

  10. The orbifold cohomology of moduli of genus 3 curves

    OpenAIRE

    Pagani, Nicola; Tommasi, Orsola

    2011-01-01

    In this work we study the additive orbifold cohomology of the moduli stack of smooth genus g curves. We show that this problem reduces to investigating the rational cohomology of moduli spaces of cyclic covers of curves where the genus of the covering curve is g. Then we work out the case of genus g=3. Furthermore, we determine the part of the orbifold cohomology of the Deligne-Mumford compactification of the moduli space of genus 3 curves that comes from the Zariski closure of the inertia st...

  11. Manifolds, sheaves, and cohomology

    CERN Document Server

    Wedhorn, Torsten

    2016-01-01

    This book explains techniques that are essential in almost all branches of modern geometry such as algebraic geometry, complex geometry, or non-archimedian geometry. It uses the most accessible case, real and complex manifolds, as a model. The author especially emphasizes the difference between local and global questions. Cohomology theory of sheaves is introduced and its usage is illustrated by many examples. Content Topological Preliminaries - Algebraic Topological Preliminaries - Sheaves - Manifolds - Local Theory of Manifolds - Lie Groups - Torsors and Non-abelian Cech Cohomology - Bundles - Soft Sheaves - Cohomology of Complexes of Sheaves - Cohomology of Sheaves of Locally Constant Functions - Appendix: Basic Topology, The Language of Categories, Basic Algebra, Homological Algebra, Local Analysis Readership Graduate Students in Mathematics / Master of Science in Mathematics About the Author Prof. Dr. Torsten Wedhorn, Department of Mathematics, Technische Universität Darmstadt, Germany.

  12. String cohomology groups of complex projective spaces

    DEFF Research Database (Denmark)

    Ottosen, Iver Mølgaard; Bökstedt, Marcel

    2007-01-01

    Let X be a space and write LX for its free loop space equipped with the action of the circle group T given by dilation. The equivariant cohomology H*(LXhT;Z/p) is a module over H*(BT;Z/p). We give a computation of this module when X=CPr for any positive integer r and any prime number p. The compu......Let X be a space and write LX for its free loop space equipped with the action of the circle group T given by dilation. The equivariant cohomology H*(LXhT;Z/p) is a module over H*(BT;Z/p). We give a computation of this module when X=CPr for any positive integer r and any prime number p....... The computation does not use the fact that CPr is formal, nor does it use the Jones isomorphism and negative cyclic homology....

  13. Contact Cohomology of the Projective Plane

    OpenAIRE

    Ernström, Lars; Kennedy, Gary

    1997-01-01

    We construct an associative ring which is a deformation of the quantum cohomology ring of the projective plane. Just as the quantum cohomology encodes the incidence characteristic numbers of rational plane curves, the contact cohomology encodes the tangency characteristic numbers.

  14. Notes on the horizontal cohomology

    OpenAIRE

    Verbovetsky, Alexander

    1998-01-01

    This paper is devoted to the horizontal (``characteristic'') cohomology of systems of differential equations. Recent results on computing the horizontal cohomology via the compatibility complex are generalized. New results on the Vinogradov C-spectral sequence and the Krasil'shchik C-cohomology are obtained. As an application of general theory, the examples of an evolution equation and a p-form gauge theory are explicitly worked out.

  15. Generalized etale cohomology theories

    CERN Document Server

    Jardine, John F

    1997-01-01

    A generalized etale cohomology theory is a theory which is represented by a presheaf of spectra on an etale site for an algebraic variety, in analogy with the way an ordinary spectrum represents a cohomology theory for spaces. Examples include etale cohomology and etale K-theory. This book gives new and complete proofs of both Thomason's descent theorem for Bott periodic K-theory and the Nisnevich descent theorem. In doing so, it exposes most of the major ideas of the homotopy theory of presheaves of spectra, and generalized etale homology theories in particular. The treatment includes, for the purpose of adequately dealing with cup product structures, a development of stable homotopy theory for n-fold spectra, which is then promoted to the level of presheaves of n-fold spectra.   This book should be of interest to all researchers working in fields related to algebraic K-theory. The techniques presented here are essentially combinatorial, and hence algebraic. An extensive background in traditional stable hom...

  16. Multiple period integrals and cohomology

    NARCIS (Netherlands)

    Bruggeman, R.W.; Choie, YoungJu

    2016-01-01

    We give a version of the Eichler–Shimura isomorphism with a nonabelian H^1 in group cohomology. Manin has given a map from vectors of cusp forms to a noncommutative cohomology set by means of iterated integrals. We show that Manin’s map is injective but far from surjective. By extending Manin’s map

  17. Mod two homology and cohomology

    CERN Document Server

    Hausmann, Jean-Claude

    2014-01-01

    Cohomology and homology modulo 2 helps the reader grasp more readily the basics of a major tool in algebraic topology. Compared to a more general approach to (co)homology this refreshing approach has many pedagogical advantages: It leads more quickly to the essentials of the subject, An absence of signs and orientation considerations simplifies the theory, Computations and advanced applications can be presented at an earlier stage, Simple geometrical interpretations of (co)chains. Mod 2 (co)homology was developed in the first quarter of the twentieth century as an alternative to integral homology, before both became particular cases of (co)homology with arbitrary coefficients. The first chapters of this book may serve as a basis for a graduate-level introductory course to (co)homology. Simplicial and singular mod 2 (co)homology are introduced, with their products and Steenrod squares, as well as equivariant cohomology. Classical applications include Brouwer's fixed point theorem, Poincaré duality, Borsuk-Ula...

  18. Refined Hopf Link Revisited

    CERN Document Server

    Iqbal, Amer

    2012-01-01

    We establish a relation between the refined Hopf link invariant and the S-matrix of the refined Chern-Simons theory. We show that the refined open string partition function corresponding to the Hopf link, calculated using the refined topological vertex, when expressed in the basis of Macdonald polynomials gives the S-matrix of the refined Chern-Simons theory.

  19. Rigid cohomology over Laurent series fields

    CERN Document Server

    Lazda, Christopher

    2016-01-01

    In this monograph, the authors develop a new theory of p-adic cohomology for varieties over Laurent series fields in positive characteristic, based on Berthelot's theory of rigid cohomology. Many major fundamental properties of these cohomology groups are proven, such as finite dimensionality and cohomological descent, as well as interpretations in terms of Monsky-Washnitzer cohomology and Le Stum's overconvergent site. Applications of this new theory to arithmetic questions, such as l-independence and the weight monodromy conjecture, are also discussed. The construction of these cohomology groups, analogous to the Galois representations associated to varieties over local fields in mixed characteristic, fills a major gap in the study of arithmetic cohomology theories over function fields. By extending the scope of existing methods, the results presented here also serve as a first step towards a more general theory of p-adic cohomology over non-perfect ground fields. Rigid Cohomology over Laurent Series Fields...

  20. Real and étale cohomology

    CERN Document Server

    Scheiderer, Claus

    1994-01-01

    This book makes a systematic study of the relations between the étale cohomology of a scheme and the orderings of its residue fields. A major result is that in high degrees, étale cohomology is cohomology of the real spectrum. It also contains new contributions in group cohomology and in topos theory. It is of interest to graduate students and researchers who work in algebraic geometry (not only real) and have some familiarity with the basics of étale cohomology and Grothendieck sites. Independently, it is of interest to people working in the cohomology theory of groups or in topos theory.

  1. Approximate cohomology in Banach algebras | Pourabbas ...

    African Journals Online (AJOL)

    We introduce the notions of approximate cohomology and approximate homotopy in Banach algebras and we study the relation between them. We show that the approximate homotopically equivalent cochain complexes give the same approximate cohomologies. As a special case, approximate Hochschild cohomology is ...

  2. Topics in cohomology of groups

    CERN Document Server

    Lang, Serge

    1996-01-01

    The book is a mostly translated reprint of a report on cohomology of groups from the 1950s and 1960s, originally written as background for the Artin-Tate notes on class field theory, following the cohomological approach. This report was first published (in French) by Benjamin. For this new English edition, the author added Tate's local duality, written up from letters which John Tate sent to Lang in 1958 - 1959. Except for this last item, which requires more substantial background in algebraic geometry and especially abelian varieties, the rest of the book is basically elementary, depending only on standard homological algebra at the level of first year graduate students.

  3. Fundamentals of Hopf algebras

    CERN Document Server

    Underwood, Robert G

    2015-01-01

    This text aims to provide graduate students with a self-contained introduction to topics that are at the forefront of modern algebra, namely, coalgebras, bialgebras, and Hopf algebras.  The last chapter (Chapter 4) discusses several applications of Hopf algebras, some of which are further developed in the author’s 2011 publication, An Introduction to Hopf Algebras.  The book may be used as the main text or as a supplementary text for a graduate algebra course.  Prerequisites for this text include standard material on groups, rings, modules, algebraic extension fields, finite fields, and linearly recursive sequences. The book consists of four chapters. Chapter 1 introduces algebras and coalgebras over a field K; Chapter 2 treats bialgebras; Chapter 3 discusses Hopf algebras and Chapter 4 consists of three applications of Hopf algebras. Each chapter begins with a short overview and ends with a collection of exercises which are designed to review and reinforce the material. Exercises range from straightforw...

  4. On cohomology theory for topological groups

    Indian Academy of Sciences (India)

    Tate on the vanishing of the Schur cohomology groups to the context of Weil groups [15], to show that H2 m(Wk, С∗) ...... Third Edition (McGraw-Hill Publishers). (1987). [17] Segal G, Cohomology of topological groups, 1970 Symposia Mathematica, Vol. IV. (INDAM, Rome, 1968/69) (London: Academic Press) pp. 377–387.

  5. On cohomology theory for topological groups

    Indian Academy of Sciences (India)

    We construct some new cohomology theories for topological groups and Lie groups and study some of its basic properties. For example, we introduce a cohomology theory based on measurable cochains which are continuous in a neighbourhood of the identity. We show that if and are locally compact and second ...

  6. Continuous bounded cohomology of locally compact groups

    CERN Document Server

    2001-01-01

    Recent research has repeatedly led to connections between important rigidity questions and bounded cohomology. However, the latter has remained by and large intractable. This monograph introduces the functorial study of the continuous bounded cohomology for topological groups, with coefficients in Banach modules. The powerful techniques of this more general theory have successfully solved a number of the original problems in bounded cohomology. As applications, one obtains, in particular, rigidity results for actions on the circle, for representations on complex hyperbolic spaces and on Teichmüller spaces. A special effort has been made to provide detailed proofs or references in quite some generality.

  7. De Rham cohomology and homotopy Frobenius manifolds

    NARCIS (Netherlands)

    Dotsenko, V.; Shadrin, S.; Vallette, B.

    2015-01-01

    We endow the de Rham cohomology of any Poisson or Jacobi manifold with a natural homotopy Frobenius manifold structure. This result relies on a minimal model theorem for multicomplexes and a new kind of a Hodge degeneration condition.

  8. Equivariant ordinary homology and cohomology

    CERN Document Server

    Costenoble, Steven R

    2016-01-01

    Filling a gap in the literature, this book takes the reader to the frontiers of equivariant topology, the study of objects with specified symmetries. The discussion is motivated by reference to a list of instructive “toy” examples and calculations in what is a relatively unexplored field. The authors also provide a reading path for the first-time reader less interested in working through sophisticated machinery but still desiring a rigorous understanding of the main concepts. The subject’s classical counterparts, ordinary homology and cohomology, dating back to the work of Henri Poincaré in topology, are calculational and theoretical tools which are important in many parts of mathematics and theoretical physics, particularly in the study of manifolds. Similarly powerful tools have been lacking, however, in the context of equivariant topology. Aimed at advanced graduate students and researchers in algebraic topology and related fields, the book assumes knowledge of basic algebraic topology and group act...

  9. Dualities in Persistent (Co)Homology

    Energy Technology Data Exchange (ETDEWEB)

    de Silva, Vin; Morozov, Dmitriy; Vejdemo-Johansson, Mikael

    2011-09-16

    We consider sequences of absolute and relative homology and cohomology groups that arise naturally for a filtered cell complex. We establishalgebraic relationships between their persistence modules, and show that they contain equivalent information. We explain how one can use the existingalgorithm for persistent homology to process any of the four modules, and relate it to a recently introduced persistent cohomology algorithm. Wepresent experimental evidence for the practical efficiency of the latter algorithm.

  10. Bounded cohomology of discrete groups

    CERN Document Server

    Frigerio, Roberto

    2017-01-01

    The author manages a near perfect equilibrium between necessary technicalities (always well motivated) and geometric intuition, leading the readers from the first simple definition to the most striking applications of the theory in 13 very pleasant chapters. This book can serve as an ideal textbook for a graduate topics course on the subject and become the much-needed standard reference on Gromov's beautiful theory. -Michelle Bucher The theory of bounded cohomology, introduced by Gromov in the late 1980s, has had powerful applications in geometric group theory and the geometry and topology of manifolds, and has been the topic of active research continuing to this day. This monograph provides a unified, self-contained introduction to the theory and its applications, making it accessible to a student who has completed a first course in algebraic topology and manifold theory. The book can be used as a source for research projects for master's students, as a thorough introduction to the field for graduate student...

  11. The Calabi complex and Killing sheaf cohomology

    Science.gov (United States)

    Khavkine, Igor

    2017-03-01

    It has recently been noticed that the degeneracies of the Poisson bracket of linearized gravity on constant curvature Lorentzian manifold can be described in terms of the cohomologies of a certain complex of differential operators. This complex was first introduced by Calabi and its cohomology is known to be isomorphic to that of the (locally constant) sheaf of Killing vectors. We review the structure of the Calabi complex in a novel way, with explicit calculations based on representation theory of GL(n) , and also some tools for studying its cohomology in terms of locally constant sheaves. We also conjecture how these tools would adapt to linearized gravity on other backgrounds and to other gauge theories. The presentation includes explicit formulas for the differential operators in the Calabi complex, arguments for its local exactness, discussion of generalized Poincaré duality, methods of computing the cohomology of locally constant sheaves, and example calculations of Killing sheaf cohomologies of some black hole and cosmological Lorentzian manifolds.

  12. The formal theory of Hopf algebras part II: the case of Hopf algebras ...

    African Journals Online (AJOL)

    The category HopfR of Hopf algebras over a commutative unital ring R is analyzed with respect to its categorical properties. The main results are: (1) For every ring R the category HopfR is locally presentable, it is coreflective in the category of bialgebras over R, over every R-algebra there exists a cofree Hopf algebra. (2) If ...

  13. Frobenius manifolds, quantum cohomology, and moduli spaces

    CERN Document Server

    Manin, Yuri I

    1999-01-01

    This is the first monograph dedicated to the systematic exposition of the whole variety of topics related to quantum cohomology. The subject first originated in theoretical physics (quantum string theory) and has continued to develop extensively over the last decade. The author's approach to quantum cohomology is based on the notion of the Frobenius manifold. The first part of the book is devoted to this notion and its extensive interconnections with algebraic formalism of operads, differential equations, perturbations, and geometry. In the second part of the book, the author describes the con

  14. Coxeter groups and Hopf algebras

    CERN Document Server

    Aguiar, Marcelo

    2011-01-01

    An important idea in the work of G.-C. Rota is that certain combinatorial objects give rise to Hopf algebras that reflect the manner in which these objects compose and decompose. Recent work has seen the emergence of several interesting Hopf algebras of this kind, which connect diverse subjects such as combinatorics, algebra, geometry, and theoretical physics. This monograph presents a novel geometric approach using Coxeter complexes and the projection maps of Tits for constructing and studying many of these objects as well as new ones. The first three chapters introduce the necessary backgrou

  15. Hopf algebras and congruence subgroups

    CERN Document Server

    Sommerhauser, Yorck

    2007-01-01

    We prove that the kernel of the natural action of the modular group on the center of the Drinfel'd double of a semisimple Hopf algebra is a congruence subgroup. To do this, we introduce a class of generalized Frobenius-Schur indicators and endow it with an action of the modular group that is compatible with the original one.

  16. On Artinian generalized local cohomology modules

    Indian Academy of Sciences (India)

    Math. 9 (1970) 145–160. [5] Herzog J, Komplex Ausflösungen und dualität in der lokalen Algebra (Regensburg: Habilitationsschrift, Universität) (1974). [6] Huneke C, Problems on local cohomology. Free resolutions in commutative algebra and algebraic geometry, Res. Notes Math. 2 (Boston, MA: Jones and Bartlett) (1992).

  17. Cohomology with coefficients for operadic coalgebras

    Indian Academy of Sciences (India)

    coefficients, there should be a cohomology theory for the P-coalgebra .... For any positive integer n, n will denote the group of permutations on n elements. For σ ∈ n, ϵ(σ) .... V ⊗ M to M ⊗ V . Think of η (or ητ ) as the left (or right) V -coaction on M.

  18. Cohomology of 3-dimensional color Lie algebras

    NARCIS (Netherlands)

    Piontkovski, Dmitri; Silvestrov, Sergei D.

    2007-01-01

    We develop the cohomology theory of color Lie algebras due to Scheunert-Zhang in a framework of non-homogeneous quadratic Koszul algebras. In this approach, the Chevalley-Eilenberg complex of a color Lie algebra becomes a standard Koszul complex for its universal enveloping algebra, providing a

  19. BRST symmetry and de Rham cohomology

    CERN Document Server

    Hong, Soon-Tae

    2015-01-01

    This book provides an advanced introduction to extended theories of quantum field theory and algebraic topology, including Hamiltonian quantization associated with some geometrical constraints, symplectic embedding and Hamilton-Jacobi quantization and Becci-Rouet-Stora-Tyutin (BRST) symmetry, as well as de Rham cohomology. It offers a critical overview of the research in this area and unifies the existing literature, employing a consistent notation. Although the results presented apply in principle to all alternative quantization schemes, special emphasis is placed on the BRST quantization for constrained physical systems and its corresponding de Rham cohomology group structure. These were studied by theoretical physicists from the early 1960s and appeared in attempts to quantize rigorously some physical theories such as solitons and other models subject to geometrical constraints. In particular, phenomenological soliton theories such as Skyrmion and chiral bag models have seen a revival following experiment...

  20. Renormalization of gauge theories without cohomology

    Energy Technology Data Exchange (ETDEWEB)

    Anselmi, Damiano [Universita di Pisa, Dipartimento di Fisica ' ' Enrico Fermi' ' , Pisa (Italy); INFN, Sezione di Pisa (Italy)

    2013-07-15

    We investigate the renormalization of gauge theories without assuming cohomological properties. We define a renormalization algorithm that preserves the Batalin-Vilkovisky master equation at each step and automatically extends the classical action till it contains sufficiently many independent parameters to reabsorb all divergences into parameter-redefinitions and canonical transformations. The construction is then generalized to the master functional and the field-covariant proper formalism for gauge theories. Our results hold in all manifestly anomaly-free gauge theories, power-counting renormalizable or not. The extension algorithm allows us to solve a quadratic problem, such as finding a sufficiently general solution of the master equation, even when it is not possible to reduce it to a linear (cohomological) problem. (orig.)

  1. The Wiener-Hopf method in electromagnetics

    OpenAIRE

    Zich, Rodolfo; Daniele, Vito

    2014-01-01

    A function-theoretic method, The Wiener-Hopf technique has found applications in a variety of fields, most notably in analytical studies of diffraction and scattering of waves. The Wiener‐Hopf Method in Electromagnetics is an advanced academic book which provides a rare comprehensive treatment of the Wiener-Hopf method. Using a high level mathematical approach to complex electromagnetics problems and applications, this new book illustrates the wide range of the latest applications, including ...

  2. Gromov–Witten invariants and quantum cohomology

    Indian Academy of Sciences (India)

    φ(x) ◦ dφx for all x ∈ M. These conditions are exactly the Cauchy–Riemann equations in the case .... with J, and is a Cauchy–Riemannian operator. ...... We denote by H. ∗. (M) the free part of H. ∗. (M, Z). We may consider H. ∗. (M) as de Rham cohomology consisting of classes which take integral values on all cycles: H. ∗.

  3. On the Cohomology of Twisting Sheaves on Toric Varieties

    OpenAIRE

    Nikbakht-Tehrani, M.

    1998-01-01

    Using the homogeneous coordinate ring construction of a toric variety IP defined by a complete simplicial fan and the methods of local cohomology theory we develop a framework for the calculation of cohomology groups H^{*}(IP, O(p)) of twisting sheaves O(p) on IP.

  4. Differentiable and algebroid cohomology, Van Est isomorphisms, and characteristic classes

    NARCIS (Netherlands)

    Crainic, M.

    2000-01-01

    In the rst section we discuss Morita invariance of dierentiable/algebroid cohomology. In the second section we extend the Van Est isomorphism to groupoids. As a rst application we clarify the connection between dierentiable and algebroid cohomology (proved in degree 1, and conjectured in degree 2 by

  5. Differentiable and algebroid cohomology, van Est isomorphisms, and characteristic classes

    NARCIS (Netherlands)

    Crainic, M.

    2000-01-01

    In the rst section we discuss Morita invariance of dierentiablealgebroid cohomology In the second section we present an extension of the van Est isomorphism to groupoids As a rst application we clarify the connection between dierentiable and algebroid cohomology proved in degree and conjectured in

  6. A cohomological framework for homotopy moment maps

    Science.gov (United States)

    Frégier, Yaël; Laurent-Gengoux, Camille; Zambon, Marco

    2015-11-01

    Given a Lie group acting on a manifold M preserving a closed n + 1-form ω, the notion of homotopy moment map for this action was introduced in Fregier (0000), in terms of L∞-algebra morphisms. In this note we describe homotopy moment maps as coboundaries of a certain complex. This description simplifies greatly computations, and we use it to study various properties of homotopy moment maps: their relation to equivariant cohomology, their obstruction theory, how they induce new ones on mapping spaces, and their equivalences. The results we obtain extend some of the results of Fregier (0000).

  7. A cohomological obstruction for global quasi-bi-Hamiltonian fields

    Energy Technology Data Exchange (ETDEWEB)

    Rakotondralambo, Joseph, E-mail: joseph.rakotondralambo@unimes.f [Departement de Mathematiques et Informatique, Faculte des Sciences, Universite d' Antananarivo (Madagascar)

    2011-02-14

    We introduce the notion of integrating factor for a 1-form which is an inner product of a vector fields and a 2-form, and the notion of weakly bi-Hamiltonian field also, which is locally quasi-bi-Hamiltonian. A cohomological class in some first cohomology space is associated to such vector fields when this is weakly bi-Hamiltonian and defined relatively to the above 1-form. This class is a cohomological obstruction to the existence of a global integrating factor for the 1-form.

  8. Period functions for Maass wave forms and cohomology

    CERN Document Server

    Bruggeman, R; Zagier, D; Bruggeman, R W; Zagier, D

    2015-01-01

    The authors construct explicit isomorphisms between spaces of Maass wave forms and cohomology groups for discrete cofinite groups \\Gamma\\subset\\mathrm{PSL}_2({\\mathbb{R}}). In the case that \\Gamma is the modular group \\mathrm{PSL}_2({\\mathbb{Z}}) this gives a cohomological framework for the results in Period functions for Maass wave forms. I, of J. Lewis and D. Zagier in Ann. Math. 153 (2001), 191-258, where a bijection was given between cuspidal Maass forms and period functions. The authors introduce the concepts of mixed parabolic cohomology group and semi-analytic vectors in principal serie

  9. On a quasi-periodic Hopf bifurcation

    NARCIS (Netherlands)

    Braaksma, B.L.J.; Broer, H.W.

    1987-01-01

    In this paper we study quasi-periodic Hopf bifurcations for the model problem of a quasi-periodically forced oscillator, where the frequencies remain fixed. For this purpose we first consider Stoker's problem for small damping.

  10. Homology of normal chains and cohomology of charges

    CERN Document Server

    Pauw, Th De; Pfeffer, W F

    2017-01-01

    The authors consider a category of pairs of compact metric spaces and Lipschitz maps where the pairs satisfy a linearly isoperimetric condition related to the solvability of the Plateau problem with partially free boundary. It includes properly all pairs of compact Lipschitz neighborhood retracts of a large class of Banach spaces. On this category the authors define homology and cohomology functors with real coefficients which satisfy the Eilenberg-Steenrod axioms, but reflect the metric properties of the underlying spaces. As an example they show that the zero-dimensional homology of a space in our category is trivial if and only if the space is path connected by arcs of finite length. The homology and cohomology of a pair are, respectively, locally convex and Banach spaces that are in duality. Ignoring the topological structures, the homology and cohomology extend to all pairs of compact metric spaces. For locally acyclic spaces, the authors establish a natural isomorphism between their cohomology and the �...

  11. On the Matlis duals of local cohomology modules and modules of ...

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 120; Issue 1. On the Matlis Duals of Local Cohomology Modules and Modules of Generalized Fractions. Kazem Khashyarmanesh. Volume ... Keywords. Local cohomology module; Matlis dual functor; module of generalized fractions; filter regular sequence.

  12. Homfly Polynomials of Generalized Hopf Links

    OpenAIRE

    Morton, Hugh R.; Hadji, Richard J.

    2001-01-01

    Following the recent work by T.-H. Chan in [HOMFLY polynomial of some generalized Hopf links, J. Knot Theory Ramif. 9 (2000) 865--883] on reverse string parallels of the Hopf link we give an alternative approach to finding the Homfly polynomials of these links, based on the Homfly skein of the annulus. We establish that two natural skein maps have distinct eigenvalues, answering a question raised by Chan, and use this result to calculate the Homfly polynomial of some more general reverse stri...

  13. Coset for Hopf fibration and squashing

    Energy Technology Data Exchange (ETDEWEB)

    Hatsuda, Machiko; Tomizawa, Shinya, E-mail: mhatsuda@post.kek.j, E-mail: tomizawa@post.kek.j [Theory Division, High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki 305-0801 (Japan)

    2009-11-21

    We provide a simple derivation of metrics for fundamental geometrical deformations such as Hopf fibration, squashing and the Z{sub k} quotient which play essential roles in recent studies on the AdS{sub 4}/CFT{sub 3}. A general metric formula of Hopf fibrations for complex and quaternion cosets is presented. Squashing is given by a similarity transformation which changes the metric preserving the isometric symmetry of the projective space. On the other hand, the Z{sub k} quotient is given as a lens space which changes the topology preserving the 'local' metric.

  14. Feynman graphs and related Hopf algebras

    Energy Technology Data Exchange (ETDEWEB)

    Duchamp, G H E [Institut Galilee, LIPN, CNRS UMR 7030 99 Av. J.-B. Clement, F-93430 Villetaneuse (France); Blasiak, P [H. Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences ul. Eliasza-Radzikowskiego 152, PL 31342 Cracow (Poland); Horzela, A [H. Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences ul. Eliasza-Radzikowskiego 152, PL 31342 Cracow (Poland); Penson, K A [Laboratoire de Physique Theorique de la Matiere Condensee Universite Pierre et Marie Curie, CNRS UMR 7600 Tour 24 - 2ieme et., 4 pl. Jussieu, F 75252 Paris Cedex 05 (France); Solomon, A I [Laboratoire de Physique Theorique de la Matiere Condensee Universite Pierre et Marie Curie, CNRS UMR 7600 Tour 24 - 2ieme et., 4 pl. Jussieu, F 75252 Paris Cedex 05 (France); Open University, Physics and Astronomy Department Milton Keynes MK7 6AA (United Kingdom)

    2006-02-28

    In a recent series of communications we have shown that the reordering problem of bosons leads to certain combinatorial structures. These structures may be associated with a certain graphical description. In this paper, we show that there is a Hopf Algebra structure associated with this problem which is, in a certain sense, unique.

  15. Intersection cohomology of moduli spaces of vector bundles over curves

    OpenAIRE

    Mozgovoy, Sergey; Reineke, Markus

    2015-01-01

    We compute the intersection cohomology of the moduli spaces $M(r,d)$ of semistable vector bundles of arbitrary rank $r$ and degree $d$ over a curve. To do this, we introduce new invariants, called Donaldson-Thomas invariants of a curve, which can be effectively computed by methods going back to Harder, Narasimhan, Desale and Ramanan. Our main result relates the Hodge-Euler polynomial of the intersection cohomology of $M(r,d)$ to the Donaldson-Thomas invariants. More generally, we introduce Do...

  16. A group action on Losev-Manin cohomological field theories

    NARCIS (Netherlands)

    Shadrin, S.; Zvonkine, D.

    2011-01-01

    We discuss an analog of the Givental group action for the space of solutions of the commutativity equation. There are equivalent formulations in terms of cohomology classes on the Losev-Manin compactifications of genus $0$ moduli spaces; in terms of linear algebra in the space of Laurent series; in

  17. Vanishing of cohomology over Cohen–Macaulay rings

    DEFF Research Database (Denmark)

    Christensen, Lars Winther; Holm, Henrik Granau

    2012-01-01

    A 2003 counterexample to a conjecture of Auslander brought attention to a family of rings—colloquially called AC rings—that satisfy a natural condition on vanishing of cohomology. Several results attest to the remarkable homological properties of AC rings, but their definition is barely operation...

  18. Dirac cohomology for degenerate affine Hecke-Clifford algebras

    NARCIS (Netherlands)

    Chan, K.Y.

    In this paper, we study the Dirac cohomology theory on a class of algebraic structures. The main examples of this algebraic structure are the degenerate affine Hecke-Clifford algebra of type An-1 by Nazarov and of classical types by Khongsap-Wang. The algebraic structure contains a remarkable

  19. Schwinger-Keldysh formalism. Part II: thermal equivariant cohomology

    Science.gov (United States)

    Haehl, Felix M.; Loganayagam, R.; Rangamani, Mukund

    2017-06-01

    Causally ordered correlation functions of local operators in near-thermal quantum systems computed using the Schwinger-Keldysh formalism obey a set of Ward identities. These can be understood rather simply as the consequence of a topological (BRST) algebra, called the universal Schwinger-Keldysh superalgebra, as explained in our compan-ion paper [1]. In the present paper we provide a mathematical discussion of this topological algebra. In particular, we argue that the structures can be understood in the language of extended equivariant cohomology. To keep the discussion self-contained, we provide a ba-sic review of the algebraic construction of equivariant cohomology and explain how it can be understood in familiar terms as a superspace gauge algebra. We demonstrate how the Schwinger-Keldysh construction can be succinctly encoded in terms a thermal equivariant cohomology algebra which naturally acts on the operator (super)-algebra of the quantum system. The main rationale behind this exploration is to extract symmetry statements which are robust under renormalization group flow and can hence be used to understand low-energy effective field theory of near-thermal physics. To illustrate the general prin-ciples, we focus on Langevin dynamics of a Brownian particle, rephrasing some known results in terms of thermal equivariant cohomology. As described elsewhere, the general framework enables construction of effective actions for dissipative hydrodynamics and could potentially illumine our understanding of black holes.

  20. Symmetries, supersymmetries and cohomologies in gauge theories

    Science.gov (United States)

    Bǎbǎlîc, Elena-Mirela

    2009-12-01

    The main subjects approached in the thesis are the following: a) the derivation of the interactions in two space-time dimensions in a particular class of topological BF models; b) the construction of the couplings in D ≥ 5 dimensions between one massless tensor field with the mixed symmetry (3, 1) and one with the mixed symmetry of the Riemann tensor; c) the evaluation of the existence of interactions in D ≥ 5 dimensions between two different collections of massless tensor fields with the mixed symmetries (3, 1) and (2, 2); d) the analysis of the relation between the BRST charges obtained in the pure-spinor formalism, respectively in the κ-symmetric one for the supermembrane in eleven dimensions. Our procedure for the first three subjects is based on solving the equations that describe the deformation of the solution to the master equation by means of specific cohomological techniques, while for the fourth one we will use techniques specific to the BRST Hamiltonian approach in order to write the BRST charge. The interactions are obtained under the following hypotheses: locality, Lorentz covariance, Poincare invariance, analyticity of the deformations, and preservation of the number of derivatives on each field. The first three assumptions imply that the interacting theory is local in space-time, Lorentz covariant and Poincare invariant. The analyticity of the deformations refers to the fact that the deformed solution to the master equation is analytical in the coupling constant and reduces to the original solution in the free limit. The conservation of the number of derivatives on each field with respect to the free theory means here that the following two requirements are simultaneously satisfied: (i) the derivative order of the equations of motion on each field is the same for the free and respectively for the interacting theory; (ii) the maximum number of derivatives in the interaction vertices is equal to two, i.e. the maximum number of derivatives from

  1. The geometric Hopf invariant and surgery theory

    CERN Document Server

    Crabb, Michael

    2017-01-01

    Written by leading experts in the field, this monograph provides homotopy theoretic foundations for surgery theory on higher-dimensional manifolds. Presenting classical ideas in a modern framework, the authors carefully highlight how their results relate to (and generalize) existing results in the literature. The central result of the book expresses algebraic surgery theory in terms of the geometric Hopf invariant, a construction in stable homotopy theory which captures the double points of immersions. Many illustrative examples and applications of the abstract results are included in the book, making it of wide interest to topologists. Serving as a valuable reference, this work is aimed at graduate students and researchers interested in understanding how the algebraic and geometric topology fit together in the surgery theory of manifolds. It is the only book providing such a wide-ranging historical approach to the Hopf invariant, double points and surgery theory, with many results old and new. .

  2. Differential geometry on Hopf algebras and quantum groups

    Energy Technology Data Exchange (ETDEWEB)

    Watts, Paul [Univ. of California, Berkeley, CA (United States)

    1994-12-15

    The differential geometry on a Hopf algebra is constructed, by using the basic axioms of Hopf algebras and noncommutative differential geometry. The space of generalized derivations on a Hopf algebra of functions is presented via the smash product, and used to define and discuss quantum Lie algebras and their properties. The Cartan calculus of the exterior derivative, Lie derivative, and inner derivation is found for both the universal and general differential calculi of an arbitrary Hopf algebra, and, by restricting to the quasitriangular case and using the numerical R-matrix formalism, the aforementioned structures for quantum groups are determined.

  3. Filtrations on Springer fiber cohomology and Kostka polynomials

    Science.gov (United States)

    Bellamy, Gwyn; Schedler, Travis

    2017-09-01

    We prove a conjecture which expresses the bigraded Poisson-de Rham homology of the nilpotent cone of a semisimple Lie algebra in terms of the generalized (one-variable) Kostka polynomials, via a formula suggested by Lusztig. This allows us to construct a canonical family of filtrations on the flag variety cohomology, and hence on irreducible representations of the Weyl group, whose Hilbert series are given by the generalized Kostka polynomials. We deduce consequences for the cohomology of all Springer fibers. In particular, this computes the grading on the zeroth Poisson homology of all classical finite W-algebras, as well as the filtration on the zeroth Hochschild homology of all quantum finite W-algebras, and we generalize to all homology degrees. As a consequence, we deduce a conjecture of Proudfoot on symplectic duality, relating in type A the Poisson homology of Slodowy slices to the intersection cohomology of nilpotent orbit closures. In the last section, we give an analogue of our main theorem in the setting of mirabolic D-modules.

  4. Generalized Cole–Hopf transformations for generalized Burgers ...

    Indian Academy of Sciences (India)

    2015-10-15

    Oct 15, 2015 ... A detailed review of the invention of Cole–Hopf transformations for the Burgers equation and all the subsequent works which include generalizations of the Burgers equation and the corresponding developments in Cole–Hopf transformations are documented.

  5. The Leibniz-Hopf algebra and Lyndon words

    NARCIS (Netherlands)

    M. Hazewinkel (Michiel)

    1996-01-01

    textabstractLet ${cal Z$ denote the free associative algebra ${ol Z langle Z_1 , Z_2 , ldots rangle$ over the integers. This algebra carries a Hopf algebra structure for which the comultiplication is $Z_n mapsto Sigma_{i+j=n Z_i otimes Z_j$. This the noncommutative Leibniz-Hopf algebra. It carries a

  6. Generalized Poincare algebras, Hopf algebras and {kappa}-Minkowski spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Kovacevic, D., E-mail: domagoj.kovacevic@fer.hr [Faculty of Electrical Engineering and Computing, Unska 3, HR-10000 Zagreb (Croatia); Meljanac, S., E-mail: meljanac@irb.hr [Rudjer Boskovic Institute, Bijenicka c. 54, HR-10002 Zagreb (Croatia); Pachol, A., E-mail: pachol@raunvis.hi.is [Science Institute, University of Iceland, Dunhaga 3, 107 Reykjavik (Iceland); Strajn, R., E-mail: rina.strajn@gmail.com [Rudjer Boskovic Institute, Bijenicka c. 54, HR-10002 Zagreb (Croatia)

    2012-05-01

    We propose a generalized description for the {kappa}-Poincare-Hopf algebra as a symmetry quantum group of underlying {kappa}-Minkowski spacetime. We investigate all the possible implementations of (deformed) Lorentz algebras which are compatible with the given choice of {kappa}-Minkowski algebra realization. For the given realization of {kappa}-Minkowski spacetime there is a unique {kappa}-Poincare-Hopf algebra with undeformed Lorentz algebra. We have constructed a three-parameter family of deformed Lorentz generators with {kappa}-Poincare algebras which are related to {kappa}-Poincare-Hopf algebra with undeformed Lorentz algebra. Known bases of {kappa}-Poincare-Hopf algebra are obtained as special cases. Also deformation of igl(4) Hopf algebra compatible with the {kappa}-Minkowski spacetime is presented. Some physical applications are briefly discussed.

  7. Endoscopy for GSp(4) and the cohomology of Siegel modular threefolds

    CERN Document Server

    Weissauer, Rainer

    2009-01-01

    The geometry of modular curves and the structure of their cohomology groups have been a rich source for various number-theoretical applications over the last decades. Similar applications may be expected from the arithmetic of higher dimensional modular varieties. For Siegel modular threefolds some basic results on their cohomology groups are derived in this book from considering topological trace formulas.

  8. Characteristic classes for GO (2n) in étale cohomology

    Indian Academy of Sciences (India)

    In the topological category, Holla and Nitsure determined the singular cohomology ring of the classifying space B G O ( 2 n ) of the complex Lie group G O ( 2 n ) in terms of explicit generators and relations. We extend their results to the algebraic category. The chief ingredients in this are: an extension to étale cohomology of ...

  9. Hopf and Generalized Hopf Bifurcations in a Recurrent Autoimmune Disease Model

    Science.gov (United States)

    Zhang, Wenjing; Yu, Pei

    This paper is concerned with bifurcation and stability in an autoimmune model, which was established to study an important phenomenon — blips arising from such models. This model has two equilibrium solutions, disease-free equilibrium and disease equilibrium. The positivity of the solutions of the model and the global stability of the disease-free equilibrium have been proved. In this paper, we particularly focus on Hopf bifurcation which occurs from the disease equilibrium. We present a detailed study on the use of center manifold theory and normal form theory, and derive the normal form associated with Hopf bifurcation, from which the approximate amplitude of the bifurcating limit cycles and their stability conditions are obtained. Particular attention is also paid to the bifurcation of multiple limit cycles arising from generalized Hopf bifurcation, which may yield bistable phenomenon involving equilibrium and oscillating motion. This result may explain some complex dynamical behavior in real biological systems. Numerical simulations are compared with the analytical predictions to show a very good agreement.

  10. A group action on Losev-Manin cohomological field theories

    OpenAIRE

    Shadrin, Sergey; Zvonkine, Dimitri

    2009-01-01

    We discuss an analog of the Givental group action for the space of solutions of the commutativity equation. There are equivalent formulations in terms of cohomology classes on the Losev-Manin compactifications of genus 0 moduli spaces; in terms of linear algebra in the space of Laurent series; in terms of differential operators acting on Gromov-Witten potentials; and in terms of multi-component KP tau-functions. The last approach is equivalent to the Losev-Polyubin classification that was obt...

  11. SL(2, C) group action on cohomological field theories

    Science.gov (United States)

    Basalaev, Alexey

    2018-01-01

    We introduce the S} (2,C) group action on a partition function of a cohomological field theory via a certain Givental's action. Restricted to the small phase space we describe the action via the explicit formulae on a CohFT genus g potential. We prove that applied to the total ancestor potential of a simple-elliptic singularity the action introduced coincides with the transformation of Milanov-Ruan changing the primitive form (cf. Milanov and Ruan in Gromov-Witten theory of elliptic orbifold P1 and quasi-modular forms, arXiv:1106.2321 http://arxiv.org/abs/1106.2321" TargetType="URL"/> , 2011).

  12. Ideal relaxation of the Hopf fibration

    Science.gov (United States)

    Smiet, Christopher Berg; Candelaresi, Simon; Bouwmeester, Dirk

    2017-07-01

    Ideal magnetohydrodynamics relaxation is the topology-conserving reconfiguration of a magnetic field into a lower energy state where the net force is zero. This is achieved by modeling the plasma as perfectly conducting viscous fluid. It is an important tool for investigating plasma equilibria and is often used to study the magnetic configurations in fusion devices and astrophysical plasmas. We study the equilibrium reached by a localized magnetic field through the topology conserving relaxation of a magnetic field based on the Hopf fibration in which magnetic field lines are closed circles that are all linked with one another. Magnetic fields with this topology have recently been shown to occur in non-ideal numerical simulations. Our results show that any localized field can only attain equilibrium if there is a finite external pressure, and that for such a field a Taylor state is unattainable. We find an equilibrium plasma configuration that is characterized by a lowered pressure in a toroidal region, with field lines lying on surfaces of constant pressure. Therefore, the field is in a Grad-Shafranov equilibrium. Localized helical magnetic fields are found when plasma is ejected from astrophysical bodies and subsequently relaxes against the background plasma, as well as on earth in plasmoids generated by, e.g., a Marshall gun. This work shows under which conditions an equilibrium can be reached and identifies a toroidal depression as the characteristic feature of such a configuration.

  13. Graded version of local cohomology with respect to a pair of ideals

    OpenAIRE

    Lima, P.H.; Pérez, V.H. Jorge

    2017-01-01

    In this paper, we prove some well-known results on local cohomology with respect to a pair of ideals in graded version, such as the Independence theorem, Lichtenbaum-Harshorne vanishing theorem, Basic finiteness and vanishing theorem, among others. In addition, we present a generalized version of the Melkersson theorem regarding the Artinianness of modules, and a result concerning Artinianness of local cohomology modules.

  14. Stability and Hopf bifurcation for a business cycle model with expectation and delay

    Science.gov (United States)

    Liu, Xiangdong; Cai, Wenli; Lu, Jiajun; Wang, Yangyang

    2015-08-01

    According to rational expectation hypothesis, the government will take into account the future capital stock in the process of investment decision. By introducing anticipated capital stock into an economic model with investment delay, we construct a mixed functional differential system including delay and advanced variables. The system is converted to the one containing only delay by variable substitution. The equilibrium point of the system is obtained and its dynamical characteristics such as stability, Hopf bifurcation and its stability and direction are investigated by using the related theories of nonlinear dynamics. We carry out some numerical simulations to confirm these theoretical conclusions. The results indicate that both capital stock's anticipation and investment lag are the certain factors leading to the occurrence of cyclical fluctuations in the macroeconomic system. Moreover, the level of economic fluctuation can be dampened to some extent if investment decisions are made by the reasonable short-term forecast on capital stock.

  15. The first cohomology of the mapping class group with coefficients in algebraic functions on the SL2(C) moduli space

    DEFF Research Database (Denmark)

    Andersen, Jørgen Ellegaard; Villemoes, Rasmus

    2009-01-01

    Consider a compact surface of genus at least two. We prove that the first cohomology group of the mapping class group with coefficients in the space of algebraic functions on the SL2(C) moduli space vanishes. In the genus one case, this cohomology group is infinite dimensional.......Consider a compact surface of genus at least two. We prove that the first cohomology group of the mapping class group with coefficients in the space of algebraic functions on the SL2(C) moduli space vanishes. In the genus one case, this cohomology group is infinite dimensional....

  16. Hopf bifurcation for tumor-immune competition systems with delay

    Directory of Open Access Journals (Sweden)

    Ping Bi

    2014-01-01

    Full Text Available In this article, a immune response system with delay is considered, which consists of two-dimensional nonlinear differential equations. The main purpose of this paper is to explore the Hopf bifurcation of a immune response system with delay. The general formula of the direction, the estimation formula of period and stability of bifurcated periodic solution are also given. Especially, the conditions of the global existence of periodic solutions bifurcating from Hopf bifurcations are given. Numerical simulations are carried out to illustrate the the theoretical analysis and the obtained results.

  17. An Approach to Robust Control of the Hopf Bifurcation

    Directory of Open Access Journals (Sweden)

    Giacomo Innocenti

    2011-01-01

    Full Text Available The paper illustrates a novel approach to modify the Hopf bifurcation nature via a nonlinear state feedback control, which leaves the equilibrium properties unchanged. This result is achieved by recurring to linear and nonlinear transformations, which lead the system to locally assume the ordinary differential equation representation. Third-order models are considered, since they can be seen as proper representatives of a larger class of systems. The explicit relationship between the control input and the Hopf bifurcation nature is obtained via a frequency approach, that does not need the computation of the center manifold.

  18. Quantum walks, deformed relativity and Hopf algebra symmetries.

    Science.gov (United States)

    Bisio, Alessandro; D'Ariano, Giacomo Mauro; Perinotti, Paolo

    2016-05-28

    We show how the Weyl quantum walk derived from principles in D'Ariano & Perinotti (D'Ariano & Perinotti 2014Phys. Rev. A90, 062106. (doi:10.1103/PhysRevA.90.062106)), enjoying a nonlinear Lorentz symmetry of dynamics, allows one to introduce Hopf algebras for position and momentum of the emerging particle. We focus on two special models of Hopf algebras-the usual Poincaré and theκ-Poincaré algebras. © 2016 The Author(s).

  19. Universal Baxterization for Z-graded Hopf algebras

    Energy Technology Data Exchange (ETDEWEB)

    Dancer, K A; Finch, P E; Isaac, P S [Centre for Mathematical Physics, School of Physical Sciences, University of Queensland, Brisbane 4072 (Australia)

    2007-12-14

    We present a method for Baxterizing solutions of the constant Yang-Baxter equation associated with Z-graded Hopf algebras. To demonstrate the approach, we provide examples for the Taft algebras and the quantum group U{sub q}[sl(2)]. (fast track communication)

  20. Probe Knots and Hopf Insulators with Ultracold Atoms

    Science.gov (United States)

    Deng, Dong-Ling; Wang, Sheng-Tao; Sun, Kai; Duan, L.-M.

    2018-01-01

    Knots and links are fascinating and intricate topological objects. Their influence spans from DNA and molecular chemistry to vortices in superfluid helium, defects in liquid crystals and cosmic strings in the early universe. Here we find that knotted structures also exist in a peculiar class of three-dimensional topological insulators—the Hopf insulators. In particular, we demonstrate that the momentum-space spin textures of Hopf insulators are twisted in a nontrivial way, which implies the presence of various knot and link structures. We further illustrate that the knots and nontrivial spin textures can be probed via standard time-of-flight images in cold atoms as preimage contours of spin orientations in stereographic coordinates. The extracted Hopf invariants, knots, and links are validated to be robust to typical experimental imperfections. Our work establishes the existence of knotted structures in Hopf insulators, which may have potential applications in spintronics and quantum information processing. D.L.D., S.T.W. and L.M.D. are supported by the ARL, the IARPA LogiQ program, and the AFOSR MURI program, and supported by Tsinghua University for their visits. K.S. acknowledges the support from NSF under Grant No. PHY1402971. D.L.D. is also supported by JQI-NSF-PFC and LPS-MPO-CMTC at the final stage of this paper.

  1. Euler potentials for the MHD Kamchatnov-Hopf soliton solution

    NARCIS (Netherlands)

    Semenov, VS; Korovinski, DB; Biernat, HK

    2002-01-01

    In the MHD description of plasma phenomena the concept of magnetic helicity turns out to be very useful. We present here an example of introducing Euler potentials into a topological MHD soliton which has non-trivial helicity. The MHD soliton solution (Kamchatnov, 1982) is based on the Hopf

  2. Generalized Cole–Hopf transformations for generalized Burgers ...

    Indian Academy of Sciences (India)

    2015-10-15

    Oct 15, 2015 ... Generalized Cole–Hopf transformations for generalized. Burgers equations. B MAYIL VAGANAN∗ and E EMILY PRIYA. Department of Applied Mathematics and Statistics, School of Mathematics,. Madurai Kamaraj University, Madurai 625 021, India. ∗Corresponding author. E-mail: vkbmv66@gmail.com.

  3. Views on the Hopf bifurcation with respect to voltage instabilities

    Energy Technology Data Exchange (ETDEWEB)

    Roa-Sepulveda, C.A. [Universidad de Concepcion, Concepcion (Chile). Dept. de Ingenieria Electrica; Knight, U.G. [Imperial Coll. of Science and Technology, London (United Kingdom). Dept. of Electrical and Electronic Engineering

    1994-12-31

    This paper presents a sensitivity study of the Hopf bifurcation phenomenon which can in theory appear in power systems, with reference to the dynamics of the process and the impact of demand characteristics. Conclusions are drawn regarding power levels at which these bifurcations could appear and concern the concept of the imaginary axis as a `hard` limit eigenvalue analyses. (author) 20 refs., 31 figs.

  4. The planar algebra of a semisimple and cosemisimple Hopf algebra

    Indian Academy of Sciences (India)

    To a semisimple and cosemisimple Hopf algebra over an algebraically closed field, we associate a planar algebra defined by generators and relations and show that it is a connected, irreducible, spherical, non-degenerate planar algebra with non-zero modulus and of depth two. This association is shown to yield a bijection ...

  5. On Toric Poisson Structures of Type (1,1) and their Cohomology

    Science.gov (United States)

    Caine, Arlo; Givens, Berit Nilsen

    2017-04-01

    We classify real Poisson structures on complex toric manifolds of type (1,1) and initiate an investigation of their Poisson cohomology. For smooth toric varieties, such structures are necessarily algebraic and are homogeneous quadratic in each of the distinguished holomorphic coordinate charts determined by the open cones of the associated simplicial fan. As an approximation to the smooth cohomology problem in each C^n chart, we consider the Poisson differential on the complex of polynomial multi-vector fields. For the algebraic problem, we compute H^0 and H^1 under the assumption that the Poisson structure is generically non-degenerate. The paper concludes with numerical investigations of the higher degree cohomology groups of (C^2,π_B) for various B.

  6. On the cohomology and inner products of the Berkovits superparticle and superstring

    Science.gov (United States)

    Chesterman, Michael

    2004-12-01

    We describe the complete cohomology of the Berkovits BRST operator for the superparticle. It is non-zero at eight ghost numbers, splitting into two quartets, the members of each quartet being completely isomorphic. Based only on considerations of the isomorphisms of the cohomology, and using only the standard inner product, we derive the inner product appropriate for string amplitudes. It is in agreement with Berkovits' conjectured prescription, which is one element of an equivalence class. We discuss the Chern-Simons style action for D=10 super-Yang-Mills, which is now manifestly superspace covariant.

  7. An explicit example of Hopf bifurcation in fluid mechanics

    Science.gov (United States)

    Kloeden, P.; Wells, R.

    1983-01-01

    It is observed that a complete and explicit example of Hopf bifurcation appears not to be known in fluid mechanics. Such an example is presented for the rotating Benard problem with free boundary conditions on the upper and lower faces, and horizontally periodic solutions. Normal modes are found for the linearization, and the Veronis computation of the wave numbers is modified to take into account the imposed horizontal periodicity. An invariant subspace of the phase space is found in which the hypotheses of the Joseph-Sattinger theorem are verified, thus demonstrating the Hopf bifurcation. The criticality calculations are carried through to demonstrate rigorously, that the bifurcation is subcritical for certain cases, and to demonstrate numerically that it is subcritical for all the cases in the paper.

  8. Hopf Bifurcation of Compound Stochastic van der Pol System

    Directory of Open Access Journals (Sweden)

    Shaojuan Ma

    2016-01-01

    Full Text Available Hopf bifurcation analysis for compound stochastic van der Pol system with a bound random parameter and Gaussian white noise is investigated in this paper. By the Karhunen-Loeve (K-L expansion and the orthogonal polynomial approximation, the equivalent deterministic van der Pol system can be deduced. Based on the bifurcation theory of nonlinear deterministic system, the critical value of bifurcation parameter is obtained and the influence of random strength δ and noise intensity σ on stochastic Hopf bifurcation in compound stochastic system is discussed. At last we found that increased δ can relocate the critical value of bifurcation parameter forward while increased σ makes it backward and the influence of δ is more sensitive than σ. The results are verified by numerical simulations.

  9. Model Reduction of Nonlinear Aeroelastic Systems Experiencing Hopf Bifurcation

    KAUST Repository

    Abdelkefi, Abdessattar

    2013-06-18

    In this paper, we employ the normal form to derive a reduced - order model that reproduces nonlinear dynamical behavior of aeroelastic systems that undergo Hopf bifurcation. As an example, we consider a rigid two - dimensional airfoil that is supported by nonlinear springs in the pitch and plunge directions and subjected to nonlinear aerodynamic loads. We apply the center manifold theorem on the governing equations to derive its normal form that constitutes a simplified representation of the aeroelastic sys tem near flutter onset (manifestation of Hopf bifurcation). Then, we use the normal form to identify a self - excited oscillator governed by a time - delay ordinary differential equation that approximates the dynamical behavior while reducing the dimension of the original system. Results obtained from this oscillator show a great capability to predict properly limit cycle oscillations that take place beyond and above flutter as compared with the original aeroelastic system.

  10. Hopf Maps, Lowest Landau Level, and Fuzzy Spheres

    Directory of Open Access Journals (Sweden)

    Kazuki Hasebe

    2010-09-01

    Full Text Available This paper is a review of monopoles, lowest Landau level, fuzzy spheres, and their mutual relations. The Hopf maps of division algebras provide a prototype relation between monopoles and fuzzy spheres. Generalization of complex numbers to Clifford algebra is exactly analogous to generalization of fuzzy two-spheres to higher dimensional fuzzy spheres. Higher dimensional fuzzy spheres have an interesting hierarchical structure made of ''compounds'' of lower dimensional spheres. We give a physical interpretation for such particular structure of fuzzy spheres by utilizing Landau models in generic even dimensions. With Grassmann algebra, we also introduce a graded version of the Hopf map, and discuss its relation to fuzzy supersphere in context of supersymmetric Landau model.

  11. A generic Hopf algebra for quantum statistical mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, A I [Physics and Astronomy Department, The Open University, Milton Keynes MK7 6AA (United Kingdom); Duchamp, G H E [Institut Galilee, LIPN, CNRS UMR 7030 99 Av. J-B Clement, F-93430 Villetaneuse (France); Blasiak, P; Horzela, A [H Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Division of Theoretical Physics, ul. Eliasza-Radzikowskiego 152, PL 31-342 Krakow (Poland); Penson, K A, E-mail: a.i.solomon@open.ac.u, E-mail: gduchamp2@free.f, E-mail: pawel.blasiak@ifj.edu.p, E-mail: andrzej.horzela@ifj.edu.p, E-mail: penson@lptl.jussieu.f [Lab. de Phys. Theor. de la Matiere Condensee, University of Paris VI (France)

    2010-09-15

    In this paper, we present a Hopf algebra description of a bosonic quantum model, using the elementary combinatorial elements of Bell and Stirling numbers. Our objective in doing this is as follows. Recent studies have revealed that perturbative quantum field theory (pQFT) displays an astonishing interplay between analysis (Riemann zeta functions), topology (Knot theory), combinatorial graph theory (Feynman diagrams) and algebra (Hopf structure). Since pQFT is an inherently complicated study, so far not exactly solvable and replete with divergences, the essential simplicity of the relationships between these areas can be somewhat obscured. The intention here is to display some of the above-mentioned structures in the context of a simple bosonic quantum theory, i.e. a quantum theory of non-commuting operators that do not depend on space-time. The combinatorial properties of these boson creation and annihilation operators, which is our chosen example, may be described by graphs, analogous to the Feynman diagrams of pQFT, which we show possess a Hopf algebra structure. Our approach is based on the quantum canonical partition function for a boson gas.

  12. D-brane charge, flux quantization and relative (co)homology

    NARCIS (Netherlands)

    Figueroa-O'Farrill, J.M.; Stanciu, S.

    2001-01-01

    We reconsider the problem of U(1) flux and D0-charge for D-branes in the WZW model and investigate the relationship between the different definitions that have been proposed recently. We identify the D0-charge as a particular reduction of a class in the relative cohomology of the group modulo the

  13. Characteristic classes for GO(2n) in étale cohomology

    Indian Academy of Sciences (India)

    Characteristic classes for GO(2n) in étale cohomology. SAURAV BHAUMIK. School of Mathematics, Tata Institute of Fundamental Research, Homi Bhabha Road, .... characteristic classes for G form a ring, whose addition and multiplication come from the addition and cup product structure on H. ∗ . DEFINITION 1. Let G be a ...

  14. Stable cohomology of the universal Picard varieties and the extended mapping class group

    DEFF Research Database (Denmark)

    Ebert, Johannes; Randal-Williams, Oscar

    2012-01-01

    these spaces to (a generalisation of) Kawazumi's extended mapping class groups, and hence deduce cohomological information about these. Finally, we relate these results to complex algebraic geometry. We construct a holomorphic stack classifying families of Riemann surfaces equipped with a fibrewise holomorphic...

  15. Q_l-cohomology projective planes from Enriques surfaces in odd characteristic

    OpenAIRE

    SCHÜTT, MATTHIAS

    2016-01-01

    We give a complete classification of Q_l-cohomology projective planes with isolated ADE-singularities and numerically trivial canonical bundle in odd characteristic. This leads to a beautiful relation with certain Enriques surfaces which parallels the situation in characteristic zero, yet displays intriguing subtleties.

  16. Boundary maps for C*-crossed products with R with an application to the quantum Hall effect

    CERN Document Server

    Kellendonk, J

    2003-01-01

    The boundary map in K-theory arising from the Wiener-Hopf extension of a crossed product algebra with $\\RR$ is the Connes-Thom isomorphism. In this article, the Wiener Hopf extension is combined with the Heisenberg group algebra to provide an elementary construction of a corresponding map in cyclic cohomology. It then follows directly from a non-commutative Stokes theorem that this map is dual w.r.t. Connes' pairing of cyclic cohomology with K-theory. As an application, we prove equality of quantized bulk and edge conductivities for the integer quantum Hall effect described by continuous magnetic Schrödinger operators.

  17. BCOV theory via Givental group action on cohomological field theories

    NARCIS (Netherlands)

    Shadrin, S.

    2009-01-01

    In a previous paper, Losev, the author, and Shneiberg constructed a full descendant potential associated to an arbitrary cyclic Hodge dGBV algebra. This contruction extended the construction of Barannikov and Kontsevich of solution of the WDVV equation, based on the earlier paper of Bershadsky,

  18. International Workshop "Groups, Rings, Lie and Hopf Algebras"

    CERN Document Server

    2003-01-01

    The volume is almost entirely composed of the research and expository papers by the participants of the International Workshop "Groups, Rings, Lie and Hopf Algebras", which was held at the Memorial University of Newfoundland, St. John's, NF, Canada. All four areas from the title of the workshop are covered. In addition, some chapters touch upon the topics, which belong to two or more areas at the same time. Audience: The readership targeted includes researchers, graduate and senior undergraduate students in mathematics and its applications.

  19. Differential Hopf algebra structures on the Universal Enveloping Algebra of a Lie Algebra

    NARCIS (Netherlands)

    van den Hijligenberg, N.W.; van den Hijligenberg, N.; Martini, Ruud

    1995-01-01

    We discuss a method to construct a De Rham complex (differential algebra) of Poincaré–Birkhoff–Witt type on the universal enveloping algebra of a Lie algebra g. We determine the cases in which this gives rise to a differential Hopf algebra that naturally extends the Hopf algebrastructure of U(g).

  20. Differential Hopf algebra structures on the universal enveloping algebra of a Lie algebra

    NARCIS (Netherlands)

    van den Hijligenberg, N.W.; van den Hijligenberg, N.W.; Martini, Ruud

    1995-01-01

    We discuss a method to construct a De Rham complex (differential algebra) of Poincar'e-Birkhoff-Witt-type on the universal enveloping algebra of a Lie algebra $g$. We determine the cases in which this gives rise to a differential Hopf algebra that naturally extends the Hopf algebra structure of

  1. Differential Hopf algebra structures on the universal enveloping algebra ofa Lie algebra

    NARCIS (Netherlands)

    N.W. van den Hijligenberg; R. Martini

    1995-01-01

    textabstractWe discuss a method to construct a De Rham complex (differential algebra) of Poincar'e-Birkhoff-Witt-type on the universal enveloping algebra of a Lie algebra $g$. We determine the cases in which this gives rise to a differential Hopf algebra that naturally extends the Hopf algebra

  2. Hopf-algebra description of noncommutative-spacetime symmetries

    CERN Document Server

    Agostini, A; D'Andrea, F; Andrea, Francesco D'

    2003-01-01

    In the study of certain noncommutative versions of Minkowski spacetime there is still a large ambiguity concerning the characterization of their symmetries. Adopting as our case study the kappaMinkowski noncommutative space-time, on which a large literature is already available, we propose a line of analysis of noncommutative-spacetime symmetries that relies on the introduction of a Weyl map (connecting a given function in the noncommutative Minkowski with a corresponding function in commutative Minkowski) and of a compatible notion of integration in the noncommutative spacetime. We confirm (and we establish more robustly) previous suggestions that the commutative-spacetime notion of Lie-algebra symmetries must be replaced, in the noncommutative-spacetime context, by the one of Hopf-algebra symmetries. We prove that in kappaMinkowski it is possible to construct an action which is invariant under a Poincare-like Hopf algebra of symmetries with 10 generators, in which the noncommutativity length scale has the r...

  3. Rota-Baxter algebras and the Hopf algebra of renormalization

    Energy Technology Data Exchange (ETDEWEB)

    Ebrahimi-Fard, K.

    2006-06-15

    Recently, the theory of renormalization in perturbative quantum field theory underwent some exciting new developments. Kreimer discovered an organization of Feynman graphs into combinatorial Hopf algebras. The process of renormalization is captured by a factorization theorem for regularized Hopf algebra characters. Hereby the notion of Rota-Baxter algebras enters the scene. In this work we develop in detail several mathematical aspects of Rota-Baxter algebras as they appear also in other sectors closely related to perturbative renormalization, to wit, for instance multiple-zeta-values and matrix differential equations. The Rota-Baxter picture enables us to present the algebraic underpinning for the Connes-Kreimer Birkhoff decomposition in a concise way. This is achieved by establishing a general factorization theorem for filtered algebras. Which in turn follows from a new recursion formula based on the Baker-Campbell-Hausdorff formula. This allows us to generalize a classical result due to Spitzer to non-commutative Rota-Baxter algebras. The Baker-Campbell-Hausdorff based recursion turns out to be a generalization of Magnus' expansion in numerical analysis to generalized integration operators. We will exemplify these general results by establishing a simple representation of the combinatorics of renormalization in terms of triangular matrices. We thereby recover in the presence of a Rota-Baxter operator the matrix representation of the Birkhoff decomposition of Connes and Kreimer. (orig.)

  4. Weight filtrations on log crystalline cohomologies of families of open smooth varieties

    CERN Document Server

    Nakkajima, Yukiyoshi

    2008-01-01

    In this volume, the authors construct a theory of weights on the log crystalline cohomologies of families of open smooth varieties in characteristic p>0, by defining and constructing four filtered complexes. Fundamental properties of these filtered complexes are proved, in particular the p-adic purity, the functionality of three filtered complexes, the weight-filtered base change formula, the weight-filtered Künneth formula, the weight-filtered Poincaré duality, and the E2-degeneration of p-adic weight spectral sequences. In addition, the authors state some theorems on the weight filtration and the slope filtration on the rigid cohomology of a separated scheme of finite type over a perfect field of characteristic p>0.

  5. Quantum cohomology and closed-string mirror symmetry for toric varieties

    OpenAIRE

    Smith, Jack

    2018-01-01

    We give a short new computation of the quantum cohomology of an arbitrary smooth toric variety X, by showing directly that it is isomorphic to a Jacobian-like ring, assuming the existence and properties of certain counts of pseudoholomorphic discs with boundary on a Lagrangian torus fibre. The proof is purely algebraic and uses a degeneration of the target ring which turns the Novikov parameter down to zero, where an explicit inverse can be written. The hypotheses have been verified by Fukaya...

  6. The cohomology of orbit spaces of certain free circle group actions

    Indian Academy of Sciences (India)

    Abstract. Suppose that G = S1 acts freely on a finitistic space X whose (mod p) cohomology ring is isomorphic to that of a lens space L2m−1(p;q1,...,qm) or S1 ×. CPm−1. The mod p index of the action is defined to be the largest integer n such that αn = 0, where α ϵ H2(X/G; Zp) is the nonzero characteristic class of the S1-.

  7. Inverse Problem In Optical Tomography Using Diffusion Approximation and Its Hopf-Cole Transformation

    Directory of Open Access Journals (Sweden)

    Taufiquar R. Khan

    2003-12-01

    Full Text Available In this paper, we derive the Hopf-Cole transformation to the diffusion approximation. We find the analytic solution to the one dimensional diffusion approximation and its Hopf-Cole transformation for a homogenous constant background medium. We demonstrate that for a homogenous constant background medium in one dimension, the Hopf-Cole transformation improves the stability of the inverse problem. We also derive a Green's function scaling of the higher dimensional diffusion approximation for an inhomogeneous background medium and discuss a two step reconstruction algorithm.

  8. From Quantum Mechanics to Quantum Field Theory: The Hopf route

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, A I [Physics and Astronomy Department, Open University, Milton Keynes MK7 6AA (United Kingdom); Duchamp, G H E [Institut Galilee, LIPN, CNRS UMR 7030 99 Av. J.-B. Clement, F-93430 Villetaneuse (France); Blasiak, P; Horzela, A [H. Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Division of Theoretical Physics, ul. Eliasza-Radzikowskiego 152, PL 31-342 Krakow (Poland); Penson, K A, E-mail: a.i.solomon@open.ac.uk, E-mail: gduchamp2@free.fr, E-mail: pawel.blasiak@ifj.edu.pl, E-mail: andrzej.horzela@ifj.edu.pl, E-mail: penson@lptl.jussieu.fr [Lab.de Phys.Theor. de la Matiere Condensee, University of Paris VI (France)

    2011-03-01

    We show that the combinatorial numbers known as Bell numbers are generic in quantum physics. This is because they arise in the procedure known as Normal ordering of bosons, a procedure which is involved in the evaluation of quantum functions such as the canonical partition function of quantum statistical physics, inter alia. In fact, we shall show that an evaluation of the non-interacting partition function for a single boson system is identical to integrating the exponential generating function of the Bell numbers, which is a device for encapsulating a combinatorial sequence in a single function. We then introduce a remarkable equality, the Dobinski relation, and use it to indicate why renormalisation is necessary in even the simplest of perturbation expansions for a partition function. Finally we introduce a global algebraic description of this simple model, giving a Hopf algebra, which provides a starting point for extensions to more complex physical systems.

  9. Fredholm theory for Wiener-Hopf plus Hankel operators

    OpenAIRE

    Bogveradze, Giorgi

    2008-01-01

    Na presente tese consideramos combinações algébricas de operadores de Wiener-Hopf e de Hankel com diferentes classes de símbolos de Fourier. Nomeadamente, foram considerados símbolos matriciais na classe de elementos quase periódicos, semi-quase periódicos, quase periódicos por troços e certas funções matriciais sectoriais. Adicionalmente, foi dedicada atenção também aos operadores de Toeplitz mais Hankel com símbolos quase periódicos por troços e com símbolos escalares poss...

  10. Control by time delayed feedback near a Hopf bifurcation point

    Directory of Open Access Journals (Sweden)

    Sjoerd Verduyn Lunel

    2017-12-01

    Full Text Available In this paper we study the stabilization of rotating waves using time delayed feedback control. It is our aim to put some recent results in a broader context by discussing two different methods to determine the stability of the target periodic orbit in the controlled system: 1 by directly studying the Floquet multipliers and 2 by use of the Hopf bifurcation theorem. We also propose an extension of the Pyragas control scheme for which the controlled system becomes a functional differential equation of neutral type. Using the observation that we are able to determine the direction of bifurcation by a relatively simple calculation of the root tendency, we find stability conditions for the periodic orbit as a solution of the neutral type equation.

  11. Quasi-Hopf twistors for elliptic quantum groups

    CERN Document Server

    Jimbo, M; Odake, S; Shiraishi, J

    1997-01-01

    The Yang-Baxter equation admits two classes of elliptic solutions, the vertex type and the face type. On the basis of these solutions, two types of elliptic quantum groups have been introduced (Foda et al., Felder). Fronsdal made a penetrating observation that both of them are quasi-Hopf algebras, obtained by twisting the standard quantum affine algebra U_q(g). In this paper we present an explicit formula for the twistors in the form of an infinite product of the universal R matrix of U_q(g). We also prove the shifted cocycle condition for the twistors, thereby completing Fronsdal's findings. This construction entails that, for generic values of the deformation parameters, representation theory for U_q(g) carries over to the elliptic algebras, including such objects as evaluation modules, highest weight modules and vertex operators. In particular, we confirm the conjectures of Foda et al. concerning the elliptic algebra A_{q,p}(^sl_2).

  12. Two-Tone Suppression and Combination Tone Generation as Computations Performed by the Hopf Cochlea

    Science.gov (United States)

    Stoop, R.; Kern, A.

    2004-12-01

    Recent evidence suggests that the compressive nonlinearity responsible for the extreme dynamic range of the mammalian cochlea is implemented in the form of Hopf amplifiers. Whereas Helmholtz's original concept of the cochlea was that of a frequency analyzer, Hopf amplifiers can be stimulated not only by one, but also by neighboring frequencies. To reduce the resulting computational overhead, the mammalian cochlea is aided by two-tone suppression. We show that the laws governing two-tone suppression and the generation of combination tones naturally emerge from the Hopf-cochlea concept. Thus the Hopf concept of the cochlea reproduces not only local properties like the correct frequency response, but additionally accounts for more complex hearing phenomena that may be related to auditory signal computation.

  13. Studies on the Existence of Unstable Oscillatory Patterns Bifurcating from Hopf Bifurcations in a Turing Model

    Directory of Open Access Journals (Sweden)

    Yan Zhang

    2014-01-01

    Full Text Available We revisit a homogeneous reaction-diffusion Turing model subject to the Neumann boundary conditions in the one-dimensional spatial domain. With the help of the Hopf bifurcation theory applicable to the reaction-diffusion equations, we are capable of proving the existence of Hopf bifurcations, which suggests the existence of spatially homogeneous and nonhomogeneous periodic solutions of this particular system. In particular, we also prove that the spatial homogeneous periodic solutions bifurcating from the smallest Hopf bifurcation point of the system are always unstable. This together with the instability results of the spatially nonhomogeneous periodic solutions by Yi et al., 2009, indicates that, in this model, all the oscillatory patterns from Hopf bifurcations are unstable.

  14. Global Hopf Bifurcation for a Predator-Prey System with Three Delays

    Science.gov (United States)

    Jiang, Zhichao; Wang, Lin

    2017-06-01

    In this paper, a delayed predator-prey model is considered. The existence and stability of the positive equilibrium are investigated by choosing the delay τ = τ1 + τ2 as a bifurcation parameter. We see that Hopf bifurcation can occur as τ crosses some critical values. The direction of the Hopf bifurcations and the stability of the bifurcation periodic solutions are also determined by using the center manifold and normal form theory. Furthermore, based on the global Hopf bifurcation theorem for general function differential equations, which was established by J. Wu using fixed point theorem and degree theory methods, the existence of global Hopf bifurcation is investigated. Finally, numerical simulations to support the analytical conclusions are carried out.

  15. Stability and Hopf Bifurcation in a Delayed SEIRS Worm Model in Computer Network

    Directory of Open Access Journals (Sweden)

    Zizhen Zhang

    2013-01-01

    Full Text Available A delayed SEIRS epidemic model with vertical transmission in computer network is considered. Sufficient conditions for local stability of the positive equilibrium and existence of local Hopf bifurcation are obtained by analyzing distribution of the roots of the associated characteristic equation. Furthermore, the direction of the local Hopf bifurcation and the stability of the bifurcating periodic solutions are determined by using the normal form theory and center manifold theorem. Finally, a numerical example is presented to verify the theoretical analysis.

  16. Hopf bifurcation in love dynamical models with nonlinear couples and time delays

    Energy Technology Data Exchange (ETDEWEB)

    Liao Xiaofeng [School of Computer and Information, Chongqing Jiaotong University, Chonqing 400074 (China) and Department of Computer Science and Engineering, Chongqing University, Chongqing 400030 (China)]. E-mail: xflao@cqu.edu.cn; Ran Jiouhong [Hospital of Chongqing University, Chonqing University, Chongqing 400030 (China)

    2007-02-15

    A love dynamical models with nonlinear couples and two delays is considered. Local stability of this model is studied by analyzing the associated characteristic transcendental equation. We find that the Hopf bifurcation occurs when the sum of the two delays varies and passes a sequence of critical values. The stability and direction of the Hopf bifurcation are determined by applying the normal form theory and the center manifold theorem. Numerical example is given to illustrate our results.

  17. Stability and Hopf Bifurcation for a Delayed Computer Virus Model with Antidote in Vulnerable System

    Directory of Open Access Journals (Sweden)

    Zizhen Zhang

    2017-01-01

    Full Text Available A delayed computer virus model with antidote in vulnerable system is investigated. Local stability of the endemic equilibrium and existence of Hopf bifurcation are discussed by analyzing the associated characteristic equation. Further, direction of the Hopf bifurcation and stability of the bifurcating periodic solutions are investigated by using the normal form theory and the center manifold theorem. Finally, numerical simulations are presented to show consistency with the obtained results.

  18. Two-parameters Hopf bifurcation in the Hodgkin-Huxley model

    Energy Technology Data Exchange (ETDEWEB)

    Wang Jiang [School of Electrical and Automation Engineering, Tianjin University, Tianjin 300072 (China)]. E-mail: jiangwang@tju.edu.cn; Geng Jianming [School of Electrical and Automation Engineering, Tianjin University, Tianjin 300072 (China); Fei Xiangyang [School of Electrical and Automation Engineering, Tianjin University, Tianjin 300072 (China)

    2005-02-01

    In this paper, the Hodgkin-Huxley model is studied with the leakage conductance and the sodium reversal potential selected as parameters for a two-parameter Hopf-bifurcation analysis. The influence of bifurcation on the HH model was also discussed and algebra criterion in high dimension equations was used to identify Hopf bifurcation. In addition, this paper also discuses the bifurcation approach to inherited disorders of ion channels in skeletal muscle excitable membranes.

  19. Classification and equivariant cohomology of circle actions on 3d manifolds

    Science.gov (United States)

    He, Chen

    2017-10-01

    The classification of Seifert manifolds was given in terms of numeric data by Seifert (1933), and then generalized by Raymond (1968) and Orlik and Raymond (1968) to circle actions on closed 3d manifolds. In this paper, we further generalize the classification to circle actions on 3d manifolds with boundaries by adding a numeric parameter and a graph of cycles. Then, we describe the rational equivariant cohomology of 3d manifolds with circle actions in terms of ring, module and vector-space structures. We also compute equivariant Betti numbers and Poincaré series for these manifolds and discuss the equivariant formality.

  20. Quantum Dynamics on the Worldvolume from Classical su(n Cohomology

    Directory of Open Access Journals (Sweden)

    José M. Isidro

    2008-04-01

    Full Text Available A key symmetry of classical p-branes is invariance under worldvolume diffeomorphisms. Under the assumption that the worldvolume, at fixed values of the time, is a compact, quantisable Kähler manifold, we prove that the Lie algebra of volume-preserving diffeomorphisms of the worldvolume can be approximated by su(n, for n → ∞. We also prove, under the same assumptions regarding the worldvolume at fixed time, that classical Nambu brackets on the worldvolume are quantised by the multibrackets corresponding to cocycles in the cohomology of the Lie algebra su(n.

  1. Hopf Bifurcation Control of Subsynchronous Resonance Utilizing UPFC

    Directory of Open Access Journals (Sweden)

    Μ. Μ. Alomari

    2017-06-01

    Full Text Available The use of a unified power flow controller (UPFC to control the bifurcations of a subsynchronous resonance (SSR in a multi-machine power system is introduced in this study. UPFC is one of the flexible AC transmission systems (FACTS where a voltage source converter (VSC is used based on gate-turn-off (GTO thyristor valve technology. Furthermore, UPFC can be used as a stabilizer by means of a power system stabilizer (PSS. The considered system is a modified version of the second system of the IEEE second benchmark model of subsynchronous resonance where the UPFC is added to its transmission line. The dynamic effects of the machine components on SSR are considered. Time domain simulations based on the complete nonlinear dynamical mathematical model are used for numerical simulations. The results in case of including UPFC are compared to the case where the transmission line is conventionally compensated (without UPFC where two Hopf bifurcations are predicted with unstable operating point at wide range of compensation levels. For UPFC systems, it is worth to mention that the operating point of the system never loses stability at all realistic compensation degrees and therefore all power system bifurcations have been eliminated.

  2. Cyclic Vitalism

    DEFF Research Database (Denmark)

    Halse, Sven

    2014-01-01

    Over the past decade, Scandinavian and German scholars have been active in the redefinition of the terms ‘Vitalism‘ and ‘Vitalist’ as descriptive categories for analytical purposes in the fields of literary and cultural history. In this context, ‘Vitalism‘ has primarily been used to describe...... that also encompasses notions of destruction, decay and death. “All life symbols in literature around 1900 are at the same time symbols of death”. (Rasch, W. 1967:24) Through the analyses of three poems, this article aims to show concrete examples of how cyclic Vitalist thinking is embedded in poetry...

  3. Cyclic multiverses

    Science.gov (United States)

    Marosek, Konrad; Dąbrowski, Mariusz P.; Balcerzak, Adam

    2016-09-01

    Using the idea of regularization of singularities due to the variability of the fundamental constants in cosmology we study the cyclic universe models. We find two models of oscillating and non-singular mass density and pressure (`non-singular' bounce) regularized by varying gravitational constant G despite the scale factor evolution is oscillating and having sharp turning points (`singular' bounce). Both violating (big-bang) and non-violating (phantom) null energy condition models appear. Then, we extend this idea on to the multiverse containing cyclic individual universes with either growing or decreasing entropy though leaving the net entropy constant. In order to get an insight into the key idea, we consider the doubleverse with the same geometrical evolution of the two `parallel' universes with their physical evolution [physical coupling constants c(t) and G(t)] being different. An interesting point is that there is a possibility to exchange the universes at the point of maximum expansion - the fact which was already noticed in quantum cosmology. Similar scenario is also possible within the framework of Brans-Dicke theory where varying G(t) is replaced by the dynamical Brans-Dicke field φ(t) though these theories are slightly different.

  4. Cyclic biamperometry.

    Science.gov (United States)

    Rahimi, Mehdi; Mikkelsen, Susan R

    2010-03-01

    Cyclic biamperometry has been investigated as a method for the quantitation of one form of a reversibly electroactive redox couple in the presence of the other form, using the ferri-ferrocyanide couple in aqueous KCl. A triangular voltage waveform applied across two equal-area, planar gold electrodes yields peak currents that depend on the square root of the applied voltage scan rate, when one form of the redox couple is present in excess. Independent measurement of electrode-to-solution potential during biamperometric scans allowed estimation of the fractional impedance at each electrode-solution interface, and these values allow calculation of the effective potential scan rates at each electrode. Results show that when one form is present in a 5-fold excess or greater, the potential scan rate for the limiting reaction is nearly identical to the applied voltage scan rate. Similar values were obtained from impedance calculations, but discrepancies between the predicted and experimental values are evident when the two forms are present at near equivalent concentrations. When one form of the redox couple is present in excess, cyclic biamperometric peak currents depend linearly on the concentration of the limiting form, and these currents can be amplified by using cells with one electrode much larger than the other. Because this method does not require a reference electrode, it can, in principle, be readily incorporated into new electrochemical array or lab-on-a-chip devices.

  5. Hopf Bifurcation Control in a FAST TCP and RED Model via Multiple Control Schemes

    Directory of Open Access Journals (Sweden)

    Dawei Ding

    2016-01-01

    Full Text Available We focus on the Hopf bifurcation control problem of a FAST TCP model with RED gateway. The system gain parameter is chosen as the bifurcation parameter, and the stable region and stability condition of the congestion control model are given by use of the linear stability analysis. When the system gain passes through a critical value, the system loses the stability and Hopf bifurcation occurs. Considering the negative influence caused by Hopf bifurcation, we apply state feedback controller, hybrid controller, and time-delay feedback controller to postpone the onset of undesirable Hopf bifurcation. Numerical simulations show that the hybrid controller is the most sensitive method to delay the Hopf bifurcation with identical parameter conditions. However, nonlinear state feedback control and time-delay feedback control schemes have larger control parameter range in the Internet congestion control system with FAST TCP and RED gateway. Therefore, we can choose proper control method based on practical situation including unknown conditions or parameter requirements. This paper plays an important role in setting guiding system parameters for controlling the FAST TCP and RED model.

  6. From Hopf Bifurcation to Limit Cycles Control in Underactuated Mechanical Systems

    Science.gov (United States)

    Khraief Haddad, Nahla; Belghith, Safya; Gritli, Hassène; Chemori, Ahmed

    2017-06-01

    This paper deals with the problem of obtaining stable and robust oscillations of underactuated mechanical systems. It is concerned with the Hopf bifurcation analysis of a Controlled Inertia Wheel Inverted Pendulum (C-IWIP). Firstly, the stabilization was achieved with a control law based on the Interconnection, Damping, Assignment Passive Based Control method (IDA-PBC). Interestingly, the considered closed-loop system exhibits both supercritical and subcritical Hopf bifurcation for certain gains of the control law. Secondly, we used the center manifold theorem and the normal form technique to study the stability and instability of limit cycles emerging from the Hopf bifurcation. Finally, numerical simulations were conducted to validate the analytical results in order to prove that with IDA-PBC we can control not only the unstable equilibrium but also some trajectories such as limit cycles.

  7. Hopf bifurcation and chaos in a third-order phase-locked loop

    Science.gov (United States)

    Piqueira, José Roberto C.

    2017-01-01

    Phase-locked loops (PLLs) are devices able to recover time signals in several engineering applications. The literature regarding their dynamical behavior is vast, specifically considering that the process of synchronization between the input signal, coming from a remote source, and the PLL local oscillation is robust. For high-frequency applications it is usual to increase the PLL order by increasing the order of the internal filter, for guarantying good transient responses; however local parameter variations imply structural instability, thus provoking a Hopf bifurcation and a route to chaos for the phase error. Here, one usual architecture for a third-order PLL is studied and a range of permitted parameters is derived, providing a rule of thumb for designers. Out of this range, a Hopf bifurcation appears and, by increasing parameters, the periodic solution originated by the Hopf bifurcation degenerates into a chaotic attractor, therefore, preventing synchronization.

  8. La factorización de una transformada de Fourier en el método de Wiener-Hopf

    Directory of Open Access Journals (Sweden)

    José Rosales-Ortega

    2009-02-01

    Full Text Available Using the Wiener-Hopf method, we factorize the Fourier Transform of the kernel of a singular integral equation as the product of two functions: one holomorphic in the upper semiplan and the other holomophic in the lower semiplan. Keywords: function product, Fourier transform, Wiener-Hopf method.

  9. Odd-number theorem: Optical feedback control at a subcritical Hopf bifurcation in a semiconductor laser

    Science.gov (United States)

    Schikora, S.; Wünsche, H.-J.; Henneberger, F.

    2011-02-01

    A subcritical Hopf bifurcation is prepared in a multisection semiconductor laser. In the free-running state, hysteresis is absent due to noise-induced escape processes. The missing branches are recovered by stabilizing them against noise through application of phase-sensitive noninvasive delayed optical feedback control. The same type of control is successfully used to stabilize the unstable pulsations born in the Hopf bifurcation. This experimental finding represents an optical counterexample to the so-called odd-number limitation of delayed feedback control. However, as a leftover of the limitation, the domains of control are extremely small.

  10. Wiener-Hopf Design of the Two-Degree-of-Freedom Controller for the Standard Model

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yong Seok [Konyang University (Korea); Choi, Goon Ho [Han Mi Technique research institute (Korea); Park, Ki Heon [Sungkyunkwan University (Korea)

    2000-03-01

    In this paper, Wiener-Hopf design of the two-degree-of-freedom(2DOF) controller configuration is treated for the standard plant model. It is shown that the 2DOF structure makes it possible to treat the design of feedback properties and reference tracking problem separately. Wiener-Hopf factorization technique is used to obtain the optimal controller which minimizes a given quadratic cost index. The class of all stabilizing controllers that yield finite cost index is also characterized An illustrative example is given for the step reference tracking problem which can not be treated by the conventional H{sub 2} controller formula. (author). 10 refs., 3 figs.

  11. Mixed-Mode Oscillations Due to a Singular Hopf Bifurcation in a Forest Pest Model

    DEFF Research Database (Denmark)

    Brøns, Morten; Desroches, Mathieu; Krupa, Martin

    2015-01-01

    In a forest pest model, young trees are distinguished from old trees. The pest feeds on old trees. The pest grows on a fast scale, the young trees on an intermediate scale, and the old trees on a slow scale. A combination of a singular Hopf bifurcation and a “weak return” mechanism, characterized...... by a small change in one of the variables, determines the features of the mixed-mode oscillations. Period-doubling and saddle-node bifurcations lead to closed families (called isolas) of periodic solutions in a bifurcation corresponding to a singular Hopf bifurcation....

  12. Stability and Hopf bifurcation for a delayed SLBRS computer virus model.

    Science.gov (United States)

    Zhang, Zizhen; Yang, Huizhong

    2014-01-01

    By incorporating the time delay due to the period that computers use antivirus software to clean the virus into the SLBRS model a delayed SLBRS computer virus model is proposed in this paper. The dynamical behaviors which include local stability and Hopf bifurcation are investigated by regarding the delay as bifurcating parameter. Specially, direction and stability of the Hopf bifurcation are derived by applying the normal form method and center manifold theory. Finally, an illustrative example is also presented to testify our analytical results.

  13. Hopf Bifurcations of a Stochastic Fractional-Order Van der Pol System

    Directory of Open Access Journals (Sweden)

    Xiaojun Liu

    2014-01-01

    Full Text Available The Hopf bifurcation of a fractional-order Van der Pol (VDP for short system with a random parameter is investigated. Firstly, the Chebyshev polynomial approximation is applied to study the stochastic fractional-order system. Based on the method, the stochastic system is reduced to the equivalent deterministic one, and then the responses of the stochastic system can be obtained by numerical methods. Then, according to the existence conditions of Hopf bifurcation, the critical parameter value of the bifurcation is obtained by theoretical analysis. Then, numerical simulations are carried out to verify the theoretical results.

  14. Hopf Bifurcation of a Delayed Epidemic Model with Information Variable and Limited Medical Resources

    Directory of Open Access Journals (Sweden)

    Caijuan Yan

    2014-01-01

    Full Text Available We consider SIR epidemic model in which population growth is subject to logistic growth in absence of disease. We get the condition for Hopf bifurcation of a delayed epidemic model with information variable and limited medical resources. By analyzing the corresponding characteristic equations, the local stability of an endemic equilibrium and a disease-free equilibrium is discussed. If the basic reproduction ratio ℛ01, we obtain sufficient conditions under which the endemic equilibrium E* of system is locally asymptotically stable. And we also have discussed the stability and direction of Hopf bifurcations. Numerical simulations are carried out to explain the mathematical conclusions.

  15. Stability and Hopf Bifurcation for a Delayed SLBRS Computer Virus Model

    Directory of Open Access Journals (Sweden)

    Zizhen Zhang

    2014-01-01

    Full Text Available By incorporating the time delay due to the period that computers use antivirus software to clean the virus into the SLBRS model a delayed SLBRS computer virus model is proposed in this paper. The dynamical behaviors which include local stability and Hopf bifurcation are investigated by regarding the delay as bifurcating parameter. Specially, direction and stability of the Hopf bifurcation are derived by applying the normal form method and center manifold theory. Finally, an illustrative example is also presented to testify our analytical results.

  16. Uniform in Time Description for Weak Solutions of the Hopf Equation with Nonconvex Nonlinearity

    Directory of Open Access Journals (Sweden)

    Antonio Olivas Martinez

    2009-01-01

    Full Text Available We consider the Riemann problem for the Hopf equation with concave-convex flux functions. Applying the weak asymptotics method we construct a uniform in time description for the Cauchy data evolution and show that the use of this method implies automatically the appearance of the Oleinik E-condition.

  17. Dynamics at infinity and a Hopf bifurcation arising in a quadratic ...

    Indian Academy of Sciences (India)

    Dynamics at infinity and a Hopf bifurcation for a Sprott E system with a very small perturbation constant are studied in this paper. By using Poincaré compactification of polynomial vector fields in R 3 , the dynamics near infinity of the singularities is obtained. Furthermore, in accordance with the centre manifold theorem, the ...

  18. Deformations of constant mean curvature surfaces preserving symmetries and the Hopf differential

    DEFF Research Database (Denmark)

    Brander, David; Dorfmeister, Josef

    2015-01-01

    We define certain deformations between minimal and non-minimal constant mean curvature (CMC) surfaces in Euclidean space E3 which preserve the Hopf differential. We prove that, given a CMC H surface f, either minimal or not, and a fixed basepoint z0 on this surface, there is a naturally defined...

  19. Dynamics at infinity and a Hopf bifurcation arising in a quadratic ...

    Indian Academy of Sciences (India)

    Zhen Wang

    2017-12-27

    Dec 27, 2017 ... Dynamics at infinity and a Hopf bifurcation arising in a quadratic system with ... quadratic autonomous system, we raise the question: does there ..... 3200. + i. 41. 3200. , N22 = −. 23. 3200. − i. 41. 3200. ,. N12 = −. 41. 800 . The dynamics on the centre manifold is then governed by the equation. ˙w = 1. 2 iw +.

  20. Generic Hopf-Neimark-Sacker bifurcations in feed-forward systems

    NARCIS (Netherlands)

    Broer, Henk W.; Vegter, Gert

    We show that generic Hopf-Neimark-Sacker bifurcations occur in the dynamics of a large class of feed-forward coupled cell networks. To this end we present a framework for studying such bifurcations in parametrized families of perturbed forced oscillators near weak resonance points. Our approach is

  1. The Hopf algebra of (q)multiple polylogarithms with non-positive arguments

    OpenAIRE

    Ebrahimi-Fard, Kurusch; Manchon, Dominique; Singer, Johannes

    2015-01-01

    We consider multiple polylogarithms in a single variable at non-positive integers. Defining a connected graded Hopf algebra, we apply Connes' and Kreimer's algebraic Birkhoff decomposition to renormalize multiple polylogarithms at non-positive integer arguments, which satisfy the shuffle relation. The q-analogue of this result is as well presented, and compared to the classical case.

  2. Hopf bifurcation and eigenvalue sensitivity analysis of doubly fed induction generator wind turbine system

    DEFF Research Database (Denmark)

    Yang, Li Hui; Xu, Zhao; Østergaard, Jacob

    2010-01-01

    This paper first presents the Hopf bifurcation analysis for a vector-controlled doubly fed induction generator (DFIG) which is widely used in wind power conversion systems. Using three-phase back-to-back pulse-width-modulated (PWM) converters, DFIG can keep stator frequency constant under variable...

  3. Hopf Bifurcation and Eigenvalue Sensitivity Analysis of Doubly Fed Induction Generator Wind Turbine System

    DEFF Research Database (Denmark)

    Yang, Lihui; Xu, Zhao; Østergaard, Jacob

    2009-01-01

    This paper first presents the Hopf bifurcation analysis for a vector-controlled doubly fed induction generator (DFIG) which is widely used in wind power conversion systems. Using three-phase back-to-back pulse-width-modulated (PWM) converters, DFIG can keep stator frequency constant under variable...

  4. Degenerate Hopf bifurcation in a self-exciting Faraday disc dynamo

    Indian Academy of Sciences (India)

    Weiquan Pan

    2017-05-31

    May 31, 2017 ... 2Guangxi Colleges and Universities Key Laboratory of Complex System Optimization and Big Data Processing,. Yulin Normal University .... of [21], but based on the analysis of [12,22,23], for the first Lyapunov coefficient l1, .... analysis of the first Lyapunov coefficient for the Hopf bifurcation of system (2.1) ...

  5. WIENER-HOPF SOLVER WITH SMOOTH PROBABILITY DISTRIBUTIONS OF ITS COMPONENTS

    Directory of Open Access Journals (Sweden)

    Mr. Vladimir A. Smagin

    2016-12-01

    Full Text Available The Wiener – Hopf solver with smooth probability distributions of its component is presented. The method is based on hyper delta approximations of initial distributions. The use of Fourier series transformation and characteristic function allows working with the random variable method concentrated in transversal axis of absc.

  6. Degenerate Hopf bifurcation in a self-exciting Faraday disc dynamo

    Science.gov (United States)

    Pan, Weiquan; Li, Lijie

    2017-06-01

    In order to further understand a self-exciting Faraday disc dynamo (Hide et al, in Proc. R. Soc. A 452, 1369 1996), showing chaotic attractors with very complicated topological structures, we present codimension one and two (degenerate) Hopf bifurcations and prove the existence of periodic solutions. In addition, numerical simulations are given for confirming the theoretical results.

  7. Field-theory representation of gauge-gravity symmetry-protected topological invariants, group cohomology, and beyond.

    Science.gov (United States)

    Wang, Juven C; Gu, Zheng-Cheng; Wen, Xiao-Gang

    2015-01-23

    The challenge of identifying symmetry-protected topological states (SPTs) is due to their lack of symmetry-breaking order parameters and intrinsic topological orders. For this reason, it is impossible to formulate SPTs under Ginzburg-Landau theory or probe SPTs via fractionalized bulk excitations and topology-dependent ground state degeneracy. However, the partition functions from path integrals with various symmetry twists are universal SPT invariants, fully characterizing SPTs. In this work, we use gauge fields to represent those symmetry twists in closed spacetimes of any dimensionality and arbitrary topology. This allows us to express the SPT invariants in terms of continuum field theory. We show that SPT invariants of pure gauge actions describe the SPTs predicted by group cohomology, while the mixed gauge-gravity actions describe the beyond-group-cohomology SPTs. We find new examples of mixed gauge-gravity actions for U(1) SPTs in (4+1)D via the gravitational Chern-Simons term. Field theory representations of SPT invariants not only serve as tools for classifying SPTs, but also guide us in designing physical probes for them. In addition, our field theory representations are independently powerful for studying group cohomology within the mathematical context.

  8. Stability and Global Hopf Bifurcation Analysis on a Ratio-Dependent Predator-Prey Model with Two Time Delays

    Directory of Open Access Journals (Sweden)

    Huitao Zhao

    2013-01-01

    Full Text Available A ratio-dependent predator-prey model with two time delays is studied. By means of an iteration technique, sufficient conditions are obtained for the global attractiveness of the positive equilibrium. By comparison arguments, the global stability of the semitrivial equilibrium is addressed. By using the theory of functional equation and Hopf bifurcation, the conditions on which positive equilibrium exists and the quality of Hopf bifurcation are given. Using a global Hopf bifurcation result of Wu (1998 for functional differential equations, the global existence of the periodic solutions is obtained. Finally, an example for numerical simulations is also included.

  9. Stability and Hopf Bifurcation of Fractional-Order Complex-Valued Single Neuron Model with Time Delay

    Science.gov (United States)

    Wang, Zhen; Wang, Xiaohong; Li, Yuxia; Huang, Xia

    2017-12-01

    In this paper, the problems of stability and Hopf bifurcation in a class of fractional-order complex-valued single neuron model with time delay are addressed. With the help of the stability theory of fractional-order differential equations and Laplace transforms, several new sufficient conditions, which ensure the stability of the system are derived. Taking the time delay as the bifurcation parameter, Hopf bifurcation is investigated and the critical value of the time delay for the occurrence of Hopf bifurcation is determined. Finally, two representative numerical examples are given to show the effectiveness of the theoretical results.

  10. Controlling the onset of Hopf bifurcation in the Hodgkin-Huxley model

    Science.gov (United States)

    Xie, Yong; Chen, Luonan; Kang, Yan Mei; Aihara, Kazuyuki

    2008-06-01

    It is a challenging problem to establish safe and simple therapeutic methods for various complicated diseases of the nervous system, particularly dynamical diseases such as epilepsy, Alzheimer’s disease, and Parkinson’s disease. From the viewpoint of nonlinear dynamical systems, a dynamical disease can be considered to be caused by a bifurcation induced by a change in the values of one or more regulating parameter. Therefore, the theory of bifurcation control may have potential applications in the diagnosis and therapy of dynamical diseases. In this study, we employ a washout filter-aided dynamic feedback controller to control the onset of Hopf bifurcation in the Hodgkin-Huxley (HH) model. Specifically, by the control scheme, we can move the Hopf bifurcation to a desired point irrespective of whether the corresponding steady state is stable or unstable. In other words, we are able to advance or delay the Hopf bifurcation, so as to prevent it from occurring in a certain range of the externally applied current. Moreover, we can control the criticality of the bifurcation and regulate the oscillation amplitude of the bifurcated limit cycle. In the controller, there are only two terms: the linear term and the nonlinear cubic term. We show that while the former determines the location of the Hopf bifurcation, the latter regulates the criticality of the Hopf bifurcation. According to the conditions of the occurrence of Hopf bifurcation and the bifurcation stability coefficient, we can analytically deduce the linear term and the nonlinear cubic term, respectively. In addition, we also show that mixed-mode oscillations (MMOs), featuring slow action potential generation, which are frequently observed in both experiments and models of chemical and biological systems, appear in the controlled HH model. It is well known that slow firing rates in single neuron models could be achieved only by type-I neurons. However, the controlled HH model is still classified as a type

  11. Equation-free detection and continuation of a Hopf bifurcation point in a particle model of pedestrian flow

    DEFF Research Database (Denmark)

    Corradi, Olivier; Hjorth, Poul G.; Starke, Jens

    2012-01-01

    an onset of oscillations of the net pedestrian flux through the doorway, described by a Hopf bifurcation. An equation-free continuation of the Hopf point in the two parameters, door width and ratio of the pedestrian velocities of the two crowds, is performed. © 2012 Society for Industrial and Applied......Using an equation-free analysis approach we identify a Hopf bifurcation point and perform a twoparameter continuation of the Hopf point for the macroscopic dynamical behavior of an interacting particle model. Due to the nature of systems with a moderate number of particles and noise, the quality...... of the available numerical information requires the use of very robust numerical algorithms for each of the building blocks of the equation-free methodology. As an example, we consider a particle model of a crowd of pedestrians where particles interact through pairwise social forces. The pedestrians move along...

  12. Chaos and Hopf bifurcation control in a fractional-order memristor-based chaotic system with time delay

    Science.gov (United States)

    Ding, Dawei; Qian, Xin; Hu, Wei; Wang, Nian; Liang, Dong

    2017-11-01

    In this paper, a time-delayed feedback controller is proposed in order to control chaos and Hopf bifurcation in a fractional-order memristor-based chaotic system with time delay. The associated characteristic equation is established by regarding the time delay as a bifurcation parameter. A set of conditions which ensure the existence of the Hopf bifurcation are gained by analyzing the corresponding characteristic equation. Then, we discuss the influence of feedback gain on the critical value of fractional order and time delay in the controlled system. Theoretical analysis shows that the controller is effective in delaying the Hopf bifurcation critical value via decreasing the feedback gain. Finally, some numerical simulations are presented to prove the validity of our theoretical analysis and confirm that the time-delayed feedback controller is valid in controlling chaos and Hopf bifurcation in the fractional-order memristor-based system.

  13. DINÁMICA DE LA BIFURCACIÓN DE HOPF EN UNA CLASE DE MODELOS DE COMPETENCIA QUE EXHIBEN LA BIFURCACIÓN ZIP Hopf Bifurcation Dynamic in a Class of Competence Model Exhibiting Zip Bifurcation

    Directory of Open Access Journals (Sweden)

    Carlos Mario Escobar Callejas

    2011-12-01

    Full Text Available En el presente artículo de investigación se caracteriza el tipo de bifurcación de Hopf que se presenta en el fenómeno de la bifurcación de zip para un sistema tridimensional no lineal de ecuaciones diferenciales que satisface las condiciones planteadas por Butler y Farkas, las cuales modelan la competición de dos especies predadoras por una presa singular que se regenera. Se demuestra que en todas las variedades bidimensionales invariantes del sistema considerado se desarrolla una bifurcación de Hopf supercrítica lo cual es una extensión de algunos resultados sobre el tipo de bifurcación de Hopf que se forma en el fenómeno de la bifurcación de zip en sistema con respuesta funcional del predador del tipo Holling II, [1].This research article characterizes the type of Hopf bifurcation occurring in the Zip bifurcation phenomenon for a non-linear 3D system of differential equations which meets the conditions stated by Butler and Farkas to model competition of two predators struggling for a prey. It is shown that a supercritical Hopf bifurcation is developed in all invariant two-dimensional varieties of the system considered, which is an extension of some results about the kind of Hopf bifurcation which is formed in the Zip bifurcation phenomenon in a system with functional response of the Holling-type predator.

  14. Models of discretized moduli spaces, cohomological field theories, and Gaussian means

    Science.gov (United States)

    Andersen, Jørgen Ellegaard; Chekhov, Leonid O.; Norbury, Paul; Penner, Robert C.

    2015-12-01

    We prove combinatorially the explicit relation between genus filtrated s-loop means of the Gaussian matrix model and terms of the genus expansion of the Kontsevich-Penner matrix model (KPMM). The latter is the generating function for volumes of discretized (open) moduli spaces Mg,sdisc given by Ng,s(P1, …, Ps) for (P1, …, Ps) ∈ Z+s. This generating function therefore enjoys the topological recursion, and we prove that it is simultaneously the generating function for ancestor invariants of a cohomological field theory thus enjoying the Givental decomposition. We use another Givental-type decomposition obtained for this model by the second authors in 1995 in terms of special times related to the discretization of moduli spaces thus representing its asymptotic expansion terms (and therefore those of the Gaussian means) as finite sums over graphs weighted by lower-order monomials in times thus giving another proof of (quasi)polynomiality of the discrete volumes. As an application, we find the coefficients in the first subleading order for Mg,1 in two ways: by using the refined Harer-Zagier recursion and by exploiting the above Givental-type transformation. We put forward the conjecture that the above graph expansions can be used for probing the reduction structure of the Deligne-Mumford compactification M bar g, s of moduli spaces of punctured Riemann surfaces.

  15. Cyclic Vomiting Syndrome

    Science.gov (United States)

    ... anxiety to a stress management specialist for relaxation therapy or other treatments. A health care provider may prescribe medications to prevent migraines for people with cyclic vomiting syndrome. Eating, Diet, and Nutrition During the prodrome and vomiting phases of cyclic ...

  16. Optimal response to non-equilibrium disturbances under truncated Burgers-Hopf dynamics

    Science.gov (United States)

    Thalabard, Simon; Turkington, Bruce

    2017-04-01

    We model and compute the average response of truncated Burgers-Hopf dynamics to finite perturbations away from the Gibbs equipartition energy spectrum using a dynamical optimization framework recently conceptualized in a series of papers. Non-equilibrium averages are there approximated in terms of geodesic paths in probability space that ‘best-fit’ the Liouvillean dynamics over a family of quasi-equilibrium trial densities. By recasting the geodesic principle as an optimal control problem, we solve numerically for the non-equilibrium responses using an augmented Lagrangian, non-linear conjugate gradient descent method. For moderate perturbations, we find an excellent agreement between the optimal predictions and the direct numerical simulations of the truncated Burgers-Hopf dynamics. In this near-equilibrium regime, we argue that the optimal response theory provides an approximate yet predictive counterpart to fluctuation-dissipation identities.

  17. Dynamics at infinity and a Hopf bifurcation arising in a quadratic system with coexisting attractors

    Science.gov (United States)

    Wang, Zhen; Moroz, Irene; Wei, Zhouchao; Ren, Haipeng

    2018-01-01

    Dynamics at infinity and a Hopf bifurcation for a Sprott E system with a very small perturbation constant are studied in this paper. By using Poincaré compactification of polynomial vector fields in R^3, the dynamics near infinity of the singularities is obtained. Furthermore, in accordance with the centre manifold theorem, the subcritical Hopf bifurcation is analysed and obtained. Numerical simulations demonstrate the correctness of the dynamical and bifurcation analyses. Moreover, by choosing appropriate parameters, this perturbed system can exhibit chaotic, quasiperiodic and periodic dynamics, as well as some coexisting attractors, such as a chaotic attractor coexisting with a periodic attractor for a>0, and a chaotic attractor coexisting with a quasiperiodic attractor for a=0. Coexisting attractors are not associated with an unstable equilibrium and thus often go undiscovered because they may occur in a small region of parameter space, with a small basin of attraction in the space of initial conditions.

  18. A note on sub-Riemannian structures associated with complex Hopf fibrations

    Science.gov (United States)

    Li, Chengbo; Zhan, Huaying

    2013-03-01

    Sub-Riemannian structures on odd-dimensional spheres respecting the Hopf fibration naturally appear in quantum mechanics. We study the curvature maps for such a sub-Riemannian structure and express them using the Riemannian curvature tensor of the Fubini-Study metric of the complex projective space and the curvature form of the Hopf fibration. We also estimate the number of conjugate points of a sub-Riemannian extremal in terms of the bounds of the sectional curvature and the curvature form. It presents a typical example for the study of curvature maps and comparison theorems for a general corank 1 sub-Riemannian structure with symmetries done by C. Li and I. Zelenko (2011) in [2].

  19. Stability and Hopf Bifurcation in a Computer Virus Model with Multistate Antivirus

    Directory of Open Access Journals (Sweden)

    Tao Dong

    2012-01-01

    Full Text Available By considering that people may immunize their computers with countermeasures in susceptible state, exposed state and using anti-virus software may take a period of time, a computer virus model with time delay based on an SEIR model is proposed. We regard time delay as bifurcating parameter to study the dynamical behaviors which include local asymptotical stability and local Hopf bifurcation. By analyzing the associated characteristic equation, Hopf bifurcation occurs when time delay passes through a sequence of critical value. The linerized model and stability of the bifurcating periodic solutions are also derived by applying the normal form theory and the center manifold theorem. Finally, an illustrative example is also given to support the theoretical results.

  20. Re-Entrant Hexagons and Locked Turing-Hopf Fronts in the CIMA Reaction

    DEFF Research Database (Denmark)

    Mosekilde, Erik; Larsen, F.; Dewel, G.

    1998-01-01

    Aspects of the mode-interaction and pattern-selection processes in far-from-equilibrium chemical reaction-diffusion systems are studied through numerical simulation of the Lengyel-Epstein Model. The competition between Hopf oscillations and Turing stripes is investigated by following the propagat...... the propagation of a front connecting the two modes. In certain parameter regimes, mode-locking is found to occur....

  1. A nonlinear deformed su(2) algebra with a two-colour quasitriangular Hopf structure

    CERN Document Server

    Bonatsos, Dennis; Kolokotronis, P; Ludu, A; Quesne, C

    1996-01-01

    Nonlinear deformations of the enveloping algebra of su(2), involving two arbitrary functions of J_0 and generalizing the Witten algebra, were introduced some time ago by Delbecq and Quesne. In the present paper, the problem of endowing some of them with a Hopf algebraic structure is addressed by studying in detail a specific example, referred to as ${\\cal A}^+_q(1)$. This algebra is shown to possess two series of (N+1)-dimensional unitary irreducible representations, where N=0, 1, 2, .... To allow the coupling of any two such representations, a generalization of the standard Hopf axioms is proposed by proceeding in two steps. In the first one, a variant and extension of the deforming functional technique is introduced: variant because a map between two deformed algebras, su_q(2) and ${\\cal A}^+_q(1)$, is considered instead of a map between a Lie algebra and a deformed one, and extension because use is made of a two-valued functional, whose inverse is singular. As a result, the Hopf structure of su_q(2) is car...

  2. Solvability of an Integral Equation of Volterra-Wiener-Hopf Type

    Directory of Open Access Journals (Sweden)

    Nurgali K. Ashirbayev

    2014-01-01

    Full Text Available The paper presents results concerning the solvability of a nonlinear integral equation of Volterra-Stieltjes type. We show that under some assumptions that equation has a continuous and bounded solution defined on the interval 0,∞ and having a finite limit at infinity. As a special case of the mentioned integral equation we obtain an integral equation of Volterra-Wiener-Hopf type. That fact enables us to formulate convenient and handy conditions ensuring the solvability of the equation in question in the class of functions defined and continuous on the interval 0,∞ and having finite limits at infinity.

  3. Exponentially Small Heteroclinic Breakdown in the Generic Hopf-Zero Singularity

    OpenAIRE

    Baldomá Barraca, Inmaculada; Castejón i Company, Oriol; Martínez-Seara Alonso, M. Teresa

    2013-01-01

    In this paper we prove the breakdown of a heteroclinic connection in the analytic versal unfoldings of the generic Hopf-zero singularity in an open set of the parameter space. This heteroclinic orbit appears at any order if one performs the normal form around the origin, therefore it is a phenomenon “beyond all orders”. In this paper we provide a formula for the distance between the corresponding stable and unstable one-dimensional manifolds which is given by an exponentially s...

  4. Spinor Structure of P-Oriented Space, Kustaanheimo-Stifel and Hopf Bundle - Connection between Formalisms

    OpenAIRE

    Red'kov, V. M.

    2011-01-01

    In the work some relations between three techniques, Hopf's bundle, Kustaanheimo-Stiefel's bundle, 3-space with spinor structure have been examined. The spinor space is viewed as a real space that is minimally (twice as much) extended in comparison with an ordinary vector 3-space: at this instead of 2\\pi-rotation now only 4\\pi-rotation is taken to be the identity transformation in the geometrical space. With respect to a given P-orientation of an initial unextended manyfold, vector or pseudov...

  5. Cole-Hopf-like transformation for Schroedinger equations containing complex nonlinearities

    Energy Technology Data Exchange (ETDEWEB)

    Kaniadakis, G.; Scarfone, A.M. [Dipartimento di Fisica, Politecnico di Torino, Torino (Italy) and Istituto Nazionale di Fisica della Materia, Unita del Politecnico di Torino, Torino (Italy)]. E-mails: kaniadakis@polito.it; scarfone@polito.it

    2002-03-01

    We consider systems which conserve the particle number and are described by Schroedinger equations containing complex nonlinearities. In the case of canonical systems, we study their main symmetries and conservation laws. We introduce a Cole-Hopf-like transformation both for canonical and noncanonical systems, which changes the evolution equation into another one containing purely real nonlinearities, and reduces the continuity equation to the standard form of the linear theory. This approach allows us to treat, in a unifying scheme, a wide variety of canonical and noncanonical nonlinear systems, some of them already known in the literature. (author)

  6. Analysis of the Stability and Hopf Bifurcation of Currency Supply Delay in an Opened Kaldorian Business Cycle Model

    Directory of Open Access Journals (Sweden)

    Liming Zhao

    2016-01-01

    Full Text Available First of all, we establish a three-dimension open Kaldorian business cycle model under the condition of the fixed exchange rate. Secondly, with regard to the model, we discuss the existence of equilibrium point and the stability of the system near it with a time delay in currency supply as the bifurcating parameters of the system. Thirdly, we discuss the existence of Hopf bifurcation and investigate the stability of periodic solution generated by the Hopf bifurcation; then the direction of the Hopf bifurcation is given. Finally, a numerical simulation is given to confirm the theoretical results. This paper plays an important role in theoretical researching on the model of business cycle, and it is crucial for decision-maker to formulate the macroeconomic policies with the conclusions of this paper.

  7. Hopf Bifurcation in an SEIDQV Worm Propagation Model with Quarantine Strategy

    Directory of Open Access Journals (Sweden)

    Yu Yao

    2012-01-01

    Full Text Available Worms exploiting zero-day vulnerabilities have drawn significant attention owing to their enormous threats to the Internet. In general, users may immunize their computers with countermeasures in exposed and infectious state, which may take a period of time. Through theoretical analysis, time delay may lead to Hopf bifurcation phenomenon so that the worm propagation system will be unstable and uncontrollable. In view of the above factors, a quarantine strategy is thus proposed in the study. In real network, unknown worms and worm variants may lead to great risks, which misuse detection system fails to detect. However, anomaly detection is of help in detecting these kinds of worm. Consequently, our proposed quarantine strategy is built on the basis of anomaly intrusion detection system. Numerical experiments show that the quarantine strategy can diminish the infectious hosts sharply. In addition, the threshold τ0 is much larger after using our quarantine strategy, which implies that people have more time to remove worms so that the system is easier to be stable and controllable without Hopf bifurcation. Finally, simulation results match numerical ones well, which fully supports our analysis.

  8. Topological Hopf and Chain Link Semimetal States and Their Application to Co2 Mn Ga

    Science.gov (United States)

    Chang, Guoqing; Xu, Su-Yang; Zhou, Xiaoting; Huang, Shin-Ming; Singh, Bahadur; Wang, Baokai; Belopolski, Ilya; Yin, Jiaxin; Zhang, Songtian; Bansil, Arun; Lin, Hsin; Hasan, M. Zahid

    2017-10-01

    Topological semimetals can be classified by the connectivity and dimensionality of the band crossings in momentum space. The band crossings of a Dirac, Weyl, or an unconventional fermion semimetal are zero-dimensional (0D) points, whereas the band crossings of a nodal-line semimetal are one-dimensional (1D) closed loops. Here we propose that the presence of perpendicular crystalline mirror planes can protect three-dimensional (3D) band crossings characterized by nontrivial links such as a Hopf link or a coupled chain, giving rise to a variety of new types of topological semimetals. We show that the nontrivial winding number protects topological surface states distinct from those in previously known topological semimetals with a vanishing spin-orbit interaction. We also show that these nontrivial links can be engineered by tuning the mirror eigenvalues associated with the perpendicular mirror planes. Using first-principles band structure calculations, we predict the ferromagnetic full Heusler compound Co2 MnGa as a candidate. Both Hopf link and chainlike bulk band crossings and unconventional topological surface states are identified.

  9. Numerical Exploration of Kaldorian Macrodynamics: Hopf-Neimark Bifurcations and Business Cycles with Fixed Exchange Rates

    Directory of Open Access Journals (Sweden)

    Toichiro Asada

    2007-01-01

    Full Text Available We explore numerically a three-dimensional discrete-time Kaldorian macrodynamic model in an open economy with fixed exchange rates, focusing on the effects of variation of the model parameters, the speed of adjustment of the goods market α, and the degree of capital mobility β on the stability of equilibrium and on the existence of business cycles. We determine the stability region in the parameter space and find that increase of α destabilizes the equilibrium more quickly than increase of β. We determine the Hopf-Neimark bifurcation curve along which business cycles are generated, and discuss briefly the occurrence of Arnold tongues. Bifurcation and Lyapunov exponent diagrams are computed providing information on the emergence, persistence, and amplitude of the cycles and illustrating the complex dynamics involved. Examples of cycles and other attractors are presented. Finally, we discuss a two-dimensional variation of the model related to a “wealth effect,” called model 2, and show that in this case, α does not destabilize the equilibrium more quickly than β, and that a Hopf-Neimark bifurcation curve does not exist in the parameter space, therefore model 2 does not produce cycles.

  10. Symmetry, Hopf bifurcation, and the emergence of cluster solutions in time delayed neural networks

    Science.gov (United States)

    Wang, Zhen; Campbell, Sue Ann

    2017-11-01

    We consider the networks of N identical oscillators with time delayed, global circulant coupling, modeled by a system of delay differential equations with ZN symmetry. We first study the existence of Hopf bifurcations induced by the coupling time delay and then use symmetric Hopf bifurcation theory to determine how these bifurcations lead to different patterns of symmetric cluster oscillations. We apply our results to a case study: a network of FitzHugh-Nagumo neurons with diffusive coupling. For this model, we derive the asymptotic stability, global asymptotic stability, absolute instability, and stability switches of the equilibrium point in the plane of coupling time delay (τ) and excitability parameter (a). We investigate the patterns of cluster oscillations induced by the time delay and determine the direction and stability of the bifurcating periodic orbits by employing the multiple timescales method and normal form theory. We find that in the region where stability switching occurs, the dynamics of the system can be switched from the equilibrium point to any symmetric cluster oscillation, and back to equilibrium point as the time delay is increased.

  11. Genetics Home Reference: cyclic neutropenia

    Science.gov (United States)

    ... Facebook Twitter Home Health Conditions Cyclic neutropenia Cyclic neutropenia Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Cyclic neutropenia is a disorder that causes frequent infections and ...

  12. Real Topological Cyclic Homology

    DEFF Research Database (Denmark)

    Høgenhaven, Amalie

    , where O(2) is the semi-direct product of T, the multiplicative group of complex number of modulus 1, by the group G=Gal(C/R). We refer to this O(2)-spectrum as the real topological Hochschild homology. This generalization leads to a G-equivariant version of topological cyclic homology, which we call...... real topological cyclic homology. The first part of the thesis computes the G-equivariant homotopy type of the real topological cyclic homology of spherical group rings at a prime p with anti-involution induced by taking inverses in the group. The second part of the thesis investigates the derived G...

  13. Axiomatic Quantum Field Theory in Terms of Operator Product Expansions: General Framework, and Perturbation Theory via Hochschild Cohomology

    Directory of Open Access Journals (Sweden)

    Stefan Hollands

    2009-09-01

    Full Text Available In this paper, we propose a new framework for quantum field theory in terms of consistency conditions. The consistency conditions that we consider are ''associativity'' or ''factorization'' conditions on the operator product expansion (OPE of the theory, and are proposed to be the defining property of any quantum field theory. Our framework is presented in the Euclidean setting, and is applicable in principle to any quantum field theory, including non-conformal ones. In our framework, we obtain a characterization of perturbations of a given quantum field theory in terms of a certain cohomology ring of Hochschild-type. We illustrate our framework by the free field, but our constructions are general and apply also to interacting quantum field theories. For such theories, we propose a new scheme to construct the OPE which is based on the use of non-linear quantized field equations.

  14. Stability and Hopf bifurcation on a model for HIV infection of CD4{sup +} T cells with delay

    Energy Technology Data Exchange (ETDEWEB)

    Wang Xia [College of Mathematics and Information Science, Xinyang Normal University, Xinyang, Henan 464000 (China)], E-mail: xywangxia@163.com; Tao Youde [College of Mathematics and Information Science, Xinyang Normal University, Xinyang, Henan 464000 (China); Beijing Institute of Information Control, Beijing 100037 (China); Song Xinyu [College of Mathematics and Information Science, Xinyang Normal University, Xinyang, Henan 464000 (China) and Research Institute of Forest Resource Information Techniques, Chinese Academy of Forestry, Beijing 100091 (China)], E-mail: xysong88@163.com

    2009-11-15

    In this paper, a delayed differential equation model that describes HIV infection of CD4{sup +} T cells is considered. The stability of the positive equilibrium and the existence of Hopf bifurcation are investigated. In succession, using the normal form theory and center manifold argument, we derive the explicit formulas which determine the stability, direction and other properties of bifurcating periodic solutions.

  15. An appraisal of Poincaré-Hopf relation and application to topography of molecular electrostatic potentials

    Science.gov (United States)

    Roy, D.; Balanarayan, P.; Gadre, Shridhar R.

    2008-11-01

    The Poincaré-Hopf relation is studied for molecular electrostatic potentials (MESPs) of a few test systems such as cyclopropane, cyclobutane, pyridine, and benzene. Appropriate spheres centered at various points, including the center of mass of the system under study, are constructed and the MESP gradient is evaluated on the corresponding spherical grid. The change in directional nature of MESP gradient on the surface of these spheres gives indication of the critical points of the function. This is used for developing a method for locating the critical points of MESP. The strategy also enables a general definition of the Euler characteristic (EC) of the molecule, independent of any region or space. Further, the effect of basis set and level of theory on the EC is discussed.

  16. Computing the numerical solution to functional differential equations: some recent progresses towards E. Hopf's 1952 dream

    Science.gov (United States)

    Venturi, Daniele

    2016-11-01

    The fundamental importance of functional differential equations has been recognized in many areas of mathematical physics, such as fluid dynamics, quantum field theory and statistical physics. For example, in the context of fluid dynamics, the Hopf characteristic functional equation was deemed by Monin and Yaglom to be "the most compact formulation of the turbulence problem", which is the problem of determining the statistical properties of the velocity and pressure fields of Navier-Stokes equations given statistical information on the initial state. However, no effective numerical method has yet been developed to compute the solution to functional differential equations. In this talk I will provide a new perspective on this general problem, and discuss recent progresses in approximation theory for nonlinear functionals and functional equations. The proposed methods will be demonstrated through various examples.

  17. Wiener-Hopf optimal control of a hydraulic canal prototype with fractional order dynamics.

    Science.gov (United States)

    Feliu-Batlle, Vicente; Feliu-Talegón, Daniel; San-Millan, Andres; Rivas-Pérez, Raúl

    2017-06-26

    This article addresses the control of a laboratory hydraulic canal prototype that has fractional order dynamics and a time delay. Controlling this prototype is relevant since its dynamics closely resembles the dynamics of real main irrigation canals. Moreover, the dynamics of hydraulic canals vary largely when the operation regime changes since they are strongly nonlinear systems. All this makes difficult to design adequate controllers. The controller proposed in this article looks for a good time response to step commands. The design criterium for this controller is minimizing the integral performance index ISE. Then a new methodology to control fractional order processes with a time delay, based on the Wiener-Hopf control and the Padé approximation of the time delay, is developed. Moreover, in order to improve the robustness of the control system, a gain scheduling fractional order controller is proposed. Experiments show the adequate performance of the proposed controller. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  18. On the analysis of the double Hopf bifurcation in machining processes via centre manifold reduction.

    Science.gov (United States)

    Molnar, T G; Dombovari, Z; Insperger, T; Stepan, G

    2017-11-01

    The single-degree-of-freedom model of orthogonal cutting is investigated to study machine tool vibrations in the vicinity of a double Hopf bifurcation point. Centre manifold reduction and normal form calculations are performed to investigate the long-term dynamics of the cutting process. The normal form of the four-dimensional centre subsystem is derived analytically, and the possible topologies in the infinite-dimensional phase space of the system are revealed. It is shown that bistable parameter regions exist where unstable periodic and, in certain cases, unstable quasi-periodic motions coexist with the equilibrium. Taking into account the non-smoothness caused by loss of contact between the tool and the workpiece, the boundary of the bistable region is also derived analytically. The results are verified by numerical continuation. The possibility of (transient) chaotic motions in the global non-smooth dynamics is shown.

  19. Generalized Wideband Cyclic MUSIC

    Directory of Open Access Journals (Sweden)

    Zhang-Meng Liu

    2009-01-01

    Full Text Available The method of Spectral Correlation-Signal Subspace Fitting (SC-SSF fails to separate wideband cyclostationary signals with coherent second-order cyclic statistics (SOCS. Averaged Cyclic MUSIC (ACM method made up for the drawback to some degree via temporally averaging the cyclic cross-correlation of the array output. This paper interprets ACM from another perspective and proposes a new DOA estimation method by generalizing ACM for wideband cyclostationary signals. The proposed method successfully makes up for the aforementioned drawback of SC-SSF and obtains a more satisfying performance than ACM. It is also demonstrated that ACM is a simplified form of the proposed method when only a single spectral frequency is exploited, and the integration of the frequencies within the signal bandwidth helps the new method to outperform ACM.

  20. Global stability and Hopf bifurcation of a delayed computer virus propagation model with saturation incidence rate and temporary immunity

    Science.gov (United States)

    Dai, Yunxian; Lin, Yiping; Zhao, Huitao; Khalique, Chaudry Masood

    2016-06-01

    In this paper, a delayed computer virus propagation model with a saturation incidence rate and a time delay describing temporary immune period is proposed and its dynamical behaviors are studied. The threshold value ℜ0 is given to determine whether the virus dies out completely. By comparison arguments and iteration technique, sufficient conditions are obtained for the global asymptotic stabilities of the virus-free equilibrium and the virus equilibrium. Taking the delay as a parameter, local Hopf bifurcations are demonstrated. Furthermore, the direction of Hopf bifurcation and the stabilities of the bifurcating periodic solutions are determined by the normal form theory and the center manifold theorem for functional differential equations (FDEs). Finally, numerical simulations are carried out to illustrate the main theoretical results.

  1. Complexity dynamics and Hopf bifurcation analysis based on the first Lyapunov coefficient about 3D IS-LM macroeconomics system

    Science.gov (United States)

    Ma, Junhai; Ren, Wenbo; Zhan, Xueli

    2017-04-01

    Based on the study of scholars at home and abroad, this paper improves the three-dimensional IS-LM model in macroeconomics, analyzes the equilibrium point of the system and stability conditions, focuses on the parameters and complex dynamic characteristics when Hopf bifurcation occurs in the three-dimensional IS-LM macroeconomics system. In order to analyze the stability of limit cycles when Hopf bifurcation occurs, this paper further introduces the first Lyapunov coefficient to judge the limit cycles, i.e. from a practical view of the business cycle. Numerical simulation results show that within the range of most of the parameters, the limit cycle of 3D IS-LM macroeconomics is stable, that is, the business cycle is stable; with the increase of the parameters, limit cycles becomes unstable, and the value range of the parameters in this situation is small. The research results of this paper have good guide significance for the analysis of macroeconomics system.

  2. Critical dynamics of Hopf bifurcations in the corticothalamic system: Transitions from normal arousal states to epileptic seizures

    Science.gov (United States)

    Yang, Dong-Ping; Robinson, P. A.

    2017-04-01

    A physiologically based corticothalamic model of large-scale brain activity is used to analyze critical dynamics of transitions from normal arousal states to epileptic seizures, which correspond to Hopf bifurcations. This relates an abstract normal form quantitatively to underlying physiology that includes neural dynamics, axonal propagation, and time delays. Thus, a bridge is constructed that enables normal forms to be used to interpret quantitative data. The normal form of the Hopf bifurcations with delays is derived using Hale's theory, the center manifold theorem, and normal form analysis, and it is found to be explicitly expressed in terms of transfer functions and the sensitivity matrix of a reduced open-loop system. It can be applied to understand the effect of each physiological parameter on the critical dynamics and determine whether the Hopf bifurcation is supercritical or subcritical in instabilities that lead to absence and tonic-clonic seizures. Furthermore, the effects of thalamic and cortical nonlinearities on the bifurcation type are investigated, with implications for the roles of underlying physiology. The theoretical predictions about the bifurcation type and the onset dynamics are confirmed by numerical simulations and provide physiologically based criteria for determining bifurcation types from first principles. The results are consistent with experimental data from previous studies, imply that new regimes of seizure transitions may exist in clinical settings, and provide a simplified basis for control-systems interventions. Using the normal form, and the full equations from which it is derived, more complex dynamics, such as quasiperiodic cycles and saddle cycles, are discovered near the critical points of the subcritical Hopf bifurcations.

  3. Critical dynamics of Hopf bifurcations in the corticothalamic system: Transitions from normal arousal states to epileptic seizures.

    Science.gov (United States)

    Yang, Dong-Ping; Robinson, P A

    2017-04-01

    A physiologically based corticothalamic model of large-scale brain activity is used to analyze critical dynamics of transitions from normal arousal states to epileptic seizures, which correspond to Hopf bifurcations. This relates an abstract normal form quantitatively to underlying physiology that includes neural dynamics, axonal propagation, and time delays. Thus, a bridge is constructed that enables normal forms to be used to interpret quantitative data. The normal form of the Hopf bifurcations with delays is derived using Hale's theory, the center manifold theorem, and normal form analysis, and it is found to be explicitly expressed in terms of transfer functions and the sensitivity matrix of a reduced open-loop system. It can be applied to understand the effect of each physiological parameter on the critical dynamics and determine whether the Hopf bifurcation is supercritical or subcritical in instabilities that lead to absence and tonic-clonic seizures. Furthermore, the effects of thalamic and cortical nonlinearities on the bifurcation type are investigated, with implications for the roles of underlying physiology. The theoretical predictions about the bifurcation type and the onset dynamics are confirmed by numerical simulations and provide physiologically based criteria for determining bifurcation types from first principles. The results are consistent with experimental data from previous studies, imply that new regimes of seizure transitions may exist in clinical settings, and provide a simplified basis for control-systems interventions. Using the normal form, and the full equations from which it is derived, more complex dynamics, such as quasiperiodic cycles and saddle cycles, are discovered near the critical points of the subcritical Hopf bifurcations.

  4. Anticontrol of Hopf bifurcation and control of chaos for a finance system through washout filters with time delay.

    Science.gov (United States)

    Zhao, Huitao; Lu, Mengxia; Zuo, Junmei

    2014-01-01

    A controlled model for a financial system through washout-filter-aided dynamical feedback control laws is developed, the problem of anticontrol of Hopf bifurcation from the steady state is studied, and the existence, stability, and direction of bifurcated periodic solutions are discussed in detail. The obtained results show that the delay on price index has great influences on the financial system, which can be applied to suppress or avoid the chaos phenomenon appearing in the financial system.

  5. Hopf Bifurcation Characteristics of Dual-Front Axle Self-Excited Shimmy System for Heavy Truck considering Dry Friction

    Directory of Open Access Journals (Sweden)

    Daogao Wei

    2015-01-01

    Full Text Available Multiaxle steering is widely used in commercial vehicles. However, the mechanism of the self-excited shimmy produced by the multiaxle steering system is not clear until now. This study takes a dual-front axle heavy truck as sample vehicle and considers the influences of mid-shift transmission and dry friction to develop a 9 DOF dynamics model based on Lagrange’s equation. Based on the Hopf bifurcation theorem and center manifold theory, the study shows that dual-front axle shimmy is a self-excited vibration produced from Hopf bifurcation. The numerical method is adopted to determine how the size of dry friction torque influences the Hopf bifurcation characteristics of the system and to analyze the speed range of limit cycles and numerical characteristics of the shimmy system. The consistency of results of the qualitative and numerical methods shows that qualitative methods can predict the bifurcation characteristics of shimmy systems. The influences of the main system parameters on the shimmy system are also discussed. Improving the steering transition rod stiffness and dry friction torque and selecting a smaller pneumatic trail and caster angle can reduce the self-excited shimmy, reduce tire wear, and improve the driving stability of vehicles.

  6. Complexity and Hopf Bifurcation Analysis on a Kind of Fractional-Order IS-LM Macroeconomic System

    Science.gov (United States)

    Ma, Junhai; Ren, Wenbo

    On the basis of our previous research, we deepen and complete a kind of macroeconomics IS-LM model with fractional-order calculus theory, which is a good reflection on the memory characteristics of economic variables, we also focus on the influence of the variables on the real system, and improve the analysis capabilities of the traditional economic models to suit the actual macroeconomic environment. The conditions of Hopf bifurcation in fractional-order system models are briefly demonstrated, and the fractional order when Hopf bifurcation occurs is calculated, showing the inherent complex dynamic characteristics of the system. With numerical simulation, bifurcation, strange attractor, limit cycle, waveform and other complex dynamic characteristics are given; and the order condition is obtained with respect to time. We find that the system order has an important influence on the running state of the system. The system has a periodic motion when the order meets the conditions of Hopf bifurcation; the fractional-order system gradually stabilizes with the change of the order and parameters while the corresponding integer-order system diverges. This study has certain significance to policy-making about macroeconomic regulation and control.

  7. Dynamics of cyclic machines

    CERN Document Server

    Vulfson, Iosif

    2015-01-01

    This book focuses on modern methods of oscillation analysis in machines, including cyclic action mechanisms (linkages, cams, steppers, etc.). It presents schematization techniques and mathematical descriptions of oscillating systems, taking into account the variability of the parameters and nonlinearities, engineering evaluations of dynamic errors, and oscillation suppression methods. The majority of the book is devoted to the development of new methods of dynamic analysis and synthesis for cyclic machines that form regular oscillatory systems with multiple duplicate modules.  There are also sections examining aspects of general engineering interest (nonlinear dissipative forces, systems with non-stationary constraints, impacts and pseudo-impacts in clearances, etc.)  The examples in the book are based on the widely used results of theoretical and experimental studies as well as engineering calculations carried out in relation to machines used in the textile, light, polygraphic and other industries. Particu...

  8. The Lefschetz-Hopf theorem and axioms for the Lefschetz number

    Directory of Open Access Journals (Sweden)

    Brown Robert F

    2004-01-01

    Full Text Available The reduced Lefschetz number, that is, where denotes the Lefschetz number, is proved to be the unique integer-valued function on self-maps of compact polyhedra which is constant on homotopy classes such that (1 for and ; (2 if is a map of a cofiber sequence into itself, then ; (3 , where is a self-map of a wedge of circles, is the inclusion of a circle into the th summand, and is the projection onto the th summand. If is a self-map of a polyhedron and is the fixed point index of on all of , then we show that satisfies the above axioms. This gives a new proof of the normalization theorem: if is a self-map of a polyhedron, then equals the Lefschetz number of . This result is equivalent to the Lefschetz-Hopf theorem: if is a self-map of a finite simplicial complex with a finite number of fixed points, each lying in a maximal simplex, then the Lefschetz number of is the sum of the indices of all the fixed points of .

  9. Hopf bifurcation in a nonlocal nonlinear transport equation stemming from stochastic neural dynamics

    Science.gov (United States)

    Drogoul, Audric; Veltz, Romain

    2017-02-01

    In this work, we provide three different numerical evidences for the occurrence of a Hopf bifurcation in a recently derived [De Masi et al., J. Stat. Phys. 158, 866-902 (2015) and Fournier and löcherbach, Ann. Inst. H. Poincaré Probab. Stat. 52, 1844-1876 (2016)] mean field limit of a stochastic network of excitatory spiking neurons. The mean field limit is a challenging nonlocal nonlinear transport equation with boundary conditions. The first evidence relies on the computation of the spectrum of the linearized equation. The second stems from the simulation of the full mean field. Finally, the last evidence comes from the simulation of the network for a large number of neurons. We provide a "recipe" to find such bifurcation which nicely complements the works in De Masi et al. [J. Stat. Phys. 158, 866-902 (2015)] and Fournier and löcherbach [Ann. Inst. H. Poincaré Probab. Stat. 52, 1844-1876 (2016)]. This suggests in return to revisit theoretically these mean field equations from a dynamical point of view. Finally, this work shows how the noise level impacts the transition from asynchronous activity to partial synchronization in excitatory globally pulse-coupled networks.

  10. Effects of internal noise in mesoscopic chemical systems near Hopf bifurcation

    Energy Technology Data Exchange (ETDEWEB)

    Xiao Tiejun [Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026 (China); Ma Juan [Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026 (China); Hou Zhonghuai [Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026 (China); Xin Houwen [Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026 (China)

    2007-11-15

    The effects of internal noise in mesoscopic chemical oscillation systems have been studied analytically, in the parameter region close to the deterministic Hopf bifurcation. Starting from chemical Langevin equations, stochastic normal form equations are obtained, governing the evolution of the radius and phase of the stochastic oscillation. By stochastic averaging, the normal form equation can be solved analytically. Stationary distributions of the radius and auto-correlation functions of the phase variable are obtained. It is shown that internal noise can induce oscillation; even no deterministic oscillation exists. The radius of the noise-induced oscillation (NIO) becomes larger when the internal noise increases, but the correlation time becomes shorter. The trade-off between the strength and regularity of the NIO leads to a clear maximum in its signal-to-noise ratio when the internal noise changes, demonstrating the occurrence of internal noise coherent resonance. Since the intensity of the internal noise is inversely proportional to the system size, the phenomenon also indicates the existence of an optimal system size. These theoretical results are applied to a circadian clock system and excellent agreement with the numerical results is obtained.

  11. Turing-Hopf instability in biochemical reaction networks arising from pairs of subnetworks.

    Science.gov (United States)

    Mincheva, Maya; Roussel, Marc R

    2012-11-01

    Network conditions for Turing instability in biochemical systems with two biochemical species are well known and involve autocatalysis or self-activation. On the other hand general network conditions for potential Turing instabilities in large biochemical reaction networks are not well developed. A biochemical reaction network with any number of species where only one species moves is represented by a simple digraph and is modeled by a reaction-diffusion system with non-mass action kinetics. A graph-theoretic condition for potential Turing-Hopf instability that arises when a spatially homogeneous equilibrium loses its stability via a single pair of complex eigenvalues is obtained. This novel graph-theoretic condition is closely related to the negative cycle condition for oscillations in ordinary differential equation models and its generalizations, and requires the existence of a pair of subnetworks, each containing an even number of positive cycles. The technique is illustrated with a double-cycle Goodwin type model. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Cyclic quantum teleportation

    Science.gov (United States)

    Chen, Ying-Xuan; Du, Jing; Liu, Si-Yuan; Wang, Xiao-Hui

    2017-08-01

    We propose a scheme of cyclic quantum teleportation for three unknown qubits using six-qubit maximally entangled state as the quantum channel. Suppose there are three observers Alice, Bob and Charlie, each of them has been given a quantum system such as a photon or spin-1/2 particle, prepared in state unknown to them. We show how to implement the cyclic quantum teleportation where Alice can transfer her single-qubit state of qubit a to Bob, Bob can transfer his single-qubit state of qubit b to Charlie and Charlie can also transfer his single-qubit state of qubit c to Alice. We can also implement the cyclic quantum teleportation with N≥slant 3 observers by constructing a 2 N-qubit maximally entangled state as the quantum channel. By changing the quantum channel, we can change the direction of teleportation. Therefore, our scheme can realize teleportation in quantum information networks with N observers in different directions, and the security of our scheme is also investigated at the end of the paper.

  13. [Asthma and cyclic neutropenia].

    Science.gov (United States)

    Salazar Cabrera, A N; Berrón Pérez, R; Ortega Martell, J A; Onuma Takane, E

    1996-01-01

    We report a male with history of recurrent infections (recurrent oral aphtous disease [ROAD], middle ear infections and pharyngo amigdalitis) every 3 weeks since he was 7 months old. At the age of 3 years cyclic neutropenia was diagnosed with cyclic fall in the total neutrophil count in blood smear every 21 days and prophylactic antimicrobial therapy was indicated. Episodic events every 3 weeks of acute asthma and allergic rhinitis were detected at the age of 6 years old and specific immunotherapy to Bermuda grass was given during 3 years with markedly improvement in his allergic condition but not in the ROAD. He came back until the age of 16 with episodic acute asthma and ROAD. The total neutrophil count failed to 0 every 21 days and surprisingly the total eosinophil count increased up to 2,000 at the same time, with elevation of serum IgE (412 Ul/mL). Specific immunotherapy to D.pt. and Aller.a. and therapy with timomodulin was indicated. After 3 months we observed clinical improvement in the asthmatic condition and the ROAD disappeared, but the total neutrophil count did not improve. We present this case as a rare association between 2 diseases with probably no etiological relationship but may be physiopatological that could help to understand more the pathogenesis of asthma.

  14. Stability and Hopf bifurcation in a delayed model for HIV infection of CD4{sup +}T cells

    Energy Technology Data Exchange (ETDEWEB)

    Cai Liming [Department of Mathematics, Xinyang Normal University, Xinyang, 464000 Henan (China); Beijing Institute of Information Control, Beijing 100037 (China)], E-mail: lmcai06@yahoo.com.cn; Li Xuezhi [Department of Mathematics, Xinyang Normal University, Xinyang, 464000 Henan (China)

    2009-10-15

    In this paper, we consider a delayed mathematical model for the interactions of HIV infection and CD4{sup +}T cells. We first investigate the existence and stability of the Equilibria. We then study the effect of the time delay on the stability of the infected equilibrium. Criteria are given to ensure that the infected equilibrium is asymptotically stable for all delay. Moreover, by applying Nyquist criterion, the length of delay is estimated for which stability continues to hold. Finally by using a delay {tau} as a bifurcation parameter, the existence of Hopf bifurcation is also investigated. Numerical simulations are presented to illustrate the analytical results.

  15. Analysis of stability and Hopf bifurcation for a delay-differential equation model of HIV infection of CD4{sup +} T-cells

    Energy Technology Data Exchange (ETDEWEB)

    Jiang Xiaowu [Department of Mathematics, Xinyang Normal University, Xinyang 464000, Henan (China); Zhou Xueyong [Department of Mathematics, Xinyang Normal University, Xinyang 464000, Henan (China)], E-mail: xueyongzhou@126.com; Shi Xiangyun [Department of Mathematics, Xinyang Normal University, Xinyang 464000, Henan (China); Song Xinyu [Department of Mathematics, Xinyang Normal University, Xinyang 464000, Henan (China)], E-mail: xysong88@163.com

    2008-10-15

    A delay differential mathematical model that described HIV infection of CD4{sup +} T-cells is analyzed. The stability of the non-negative equilibria and the existence of Hopf bifurcation are investigated. A stability switch in the system due to variation of delay parameter has been observed, so is the phenomena of Hopf bifurcation and stable limit cycle. The estimation of the length of delay to preserve stability has been calculated. Using the normal form theory and center manifold argument, the explicit formulaes which determine the stability, the direction and the periodic of bifurcating period solutions are derived. Numerical simulations are carried out to explain the mathematical conclusions.

  16. The arabidopsis cyclic nucleotide interactome

    KAUST Repository

    Donaldson, Lara Elizabeth

    2016-05-11

    Background Cyclic nucleotides have been shown to play important signaling roles in many physiological processes in plants including photosynthesis and defence. Despite this, little is known about cyclic nucleotide-dependent signaling mechanisms in plants since the downstream target proteins remain unknown. This is largely due to the fact that bioinformatics searches fail to identify plant homologs of protein kinases and phosphodiesterases that are the main targets of cyclic nucleotides in animals. Methods An affinity purification technique was used to identify cyclic nucleotide binding proteins in Arabidopsis thaliana. The identified proteins were subjected to a computational analysis that included a sequence, transcriptional co-expression and functional annotation analysis in order to assess their potential role in plant cyclic nucleotide signaling. Results A total of twelve cyclic nucleotide binding proteins were identified experimentally including key enzymes in the Calvin cycle and photorespiration pathway. Importantly, eight of the twelve proteins were shown to contain putative cyclic nucleotide binding domains. Moreover, the identified proteins are post-translationally modified by nitric oxide, transcriptionally co-expressed and annotated to function in hydrogen peroxide signaling and the defence response. The activity of one of these proteins, GLYGOLATE OXIDASE 1, a photorespiratory enzyme that produces hydrogen peroxide in response to Pseudomonas, was shown to be repressed by a combination of cGMP and nitric oxide treatment. Conclusions We propose that the identified proteins function together as points of cross-talk between cyclic nucleotide, nitric oxide and reactive oxygen species signaling during the defence response.

  17. Cyclic transfers in school timetabling

    NARCIS (Netherlands)

    Post, Gerhard F.; Ahmadi, Samad; Geertsema, Frederik

    2012-01-01

    In this paper we propose a neighbourhood structure based on sequential/cyclic moves and a cyclic transfer algorithm for the high school timetabling problem. This method enables execution of complex moves for improving an existing solution, while dealing with the challenge of exploring the

  18. Cyclic transfers in school timetabling

    NARCIS (Netherlands)

    Post, Gerhard F.; Ahmadi, Samad; Geertsema, Frederik

    In this paper we propose a neighbourhood structure based on sequential/cyclic moves and a Cyclic Transfer algorithm for the high school timetabling problem. This method enables execution of complex moves for improving an existing solution, while dealing with the challenge of exploring the

  19. The Lefschetz-Hopf theorem and axioms for the Lefschetz number

    Directory of Open Access Journals (Sweden)

    Robert F. Brown

    2004-03-01

    Full Text Available The reduced Lefschetz number, that is, L(⋅−1 where L(⋅ denotes the Lefschetz number, is proved to be the unique integer-valued function λ on self-maps of compact polyhedra which is constant on homotopy classes such that (1 λ(fg=λ(gf for f:X→Y and g:Y→X; (2 if (f1,f2,f3 is a map of a cofiber sequence into itself, then λ(f1=λ(f1+λ(f3; (3 λ(f=−(deg(p1fe1+⋯+deg(pkfek, where f is a self-map of a wedge of k circles, er is the inclusion of a circle into the rth summand, and pr is the projection onto the rth summand. If f:X→X is a self-map of a polyhedron and I(f is the fixed point index of f on all of X, then we show that I(⋅−1 satisfies the above axioms. This gives a new proof of the normalization theorem: if f:X→X is a self-map of a polyhedron, then I(f equals the Lefschetz number L(f of f. This result is equivalent to the Lefschetz-Hopf theorem: if f:X→X is a self-map of a finite simplicial complex with a finite number of fixed points, each lying in a maximal simplex, then the Lefschetz number of f is the sum of the indices of all the fixed points of f.

  20. Hopf Bifurcation Analysis of a Gene Regulatory Network Mediated by Small Noncoding RNA with Time Delays and Diffusion

    Science.gov (United States)

    Li, Chengxian; Liu, Haihong; Zhang, Tonghua; Yan, Fang

    2017-12-01

    In this paper, a gene regulatory network mediated by small noncoding RNA involving two time delays and diffusion under the Neumann boundary conditions is studied. Choosing the sum of delays as the bifurcation parameter, the stability of the positive equilibrium and the existence of spatially homogeneous and spatially inhomogeneous periodic solutions are investigated by analyzing the corresponding characteristic equation. It is shown that the sum of delays can induce Hopf bifurcation and the diffusion incorporated into the system can effect the amplitude of periodic solutions. Furthermore, the spatially homogeneous periodic solution always exists and the spatially inhomogeneous periodic solution will arise when the diffusion coefficients of protein and mRNA are suitably small. Particularly, the small RNA diffusion coefficient is more robust and its effect on model is much less than protein and mRNA. Finally, the explicit formulae for determining the direction of Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by employing the normal form theory and center manifold theorem for partial functional differential equations. Finally, numerical simulations are carried out to illustrate our theoretical analysis.

  1. Prognosis of Cyclic Vomiting Syndrome

    Directory of Open Access Journals (Sweden)

    J. Gordon Millichap

    2016-03-01

    Full Text Available Investigators from Teikyo University School of Medicine, Tokyo, Japan, evaluated the clinical features, prognosis, and prophylaxis of cyclic vomiting syndrome and the relationship between the syndrome and levels of adrenocorticotropic/antidiuretic hormones (ACTH/ADH.

  2. Higher-dimensional analogue of the Blau-Thompson model and N{sub T}=8, D=2 Hodge-type cohomological gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Geyer, B. E-mail: geyer@itp.uni-leipzig.de; Muelsch, D. E-mail: muelsch@informatik.uni-leipzig.de

    2003-07-14

    The higher-dimensional analogue of the Blau-Thompson model in D=5 is constructed by a N{sub T}=1 topological twist of N=2, D=5 super-Yang-Mills theory. Its dimensional reduction to D=4 and D=3 gives rise to the B-model and the N{sub T}=4 equivariant extension of the Blau-Thompson model, respectively. A further dimensional reduction to D=2 provides another example of a N{sub T}=8 Hodge-type cohomological theory with global symmetry group SU(2)xSU(2)-bar. Moreover, it is shown that this theory possesses actually a larger global symmetry group SU(4) and that it agrees with the N{sub T}=8 topological twisting of N=16, D=2 super-Yang-Mills theory.

  3. Higher-dimensional analogue of the Blau-Thompson model and NT=8, /D=2 Hodge-type cohomological gauge theories

    Science.gov (United States)

    Geyer, B.; Mülsch, D.

    2003-07-01

    The higher-dimensional analogue of the Blau-Thompson model in D=5 is constructed by a NT=1 topological twist of N=2, D=5 super-Yang-Mills theory. Its dimensional reduction to D=4 and D=3 gives rise to the B-model and the NT=4 equivariant extension of the Blau-Thompson model, respectively. A further dimensional reduction to D=2 provides another example of a NT=8 Hodge-type cohomological theory with global symmetry group SU(2)⊗ overlineSU(2). Moreover, it is shown that this theory possesses actually a larger global symmetry group SU(4) and that it agrees with the NT=8 topological twisting of N=16, D=2 super-Yang-Mills theory.

  4. Beginnings of Group Cohomology

    Indian Academy of Sciences (India)

    a·f(a) + f(a) = Zo + zo, so that Zo = -Zo; that is Zo is purely imaginary, so that Zo = zo/2 - (zo)/2 = a(zo/2) - (zo/2), which shows that f is a 1-coboundary; that is Hl(G, C) = O. On the other hand, let f : G -+ C* be a 1-cocycle. Then by an argument as above, we have f(1) = 1 and f is determined by f(a) = woo We have 1 = f(1) = f(a2. ) ...

  5. Connections, curvature and cohomology

    CERN Document Server

    Greub, Werner H; Vanstone, Ray

    1976-01-01

    Imidazole and Benzimidazole Synthesis is a comprehensive survey of the known methods of syntheses and ring modification. It brings together the multitude of synthesis of the imidazole ring in a systemic way interms of specific bond formation, and recommends the most attractive synthetic approaches. It also collects non-ring-synthetic approaches to classes of compounds such as nitro-, halogeno-, and amino-imidazoles, and covers the synthesis of N-substituted compounds and preparations of specific isomers.

  6. Isotropy in group cohomology

    DEFF Research Database (Denmark)

    Ben David, Nir; Ginosar, Yuval; Meir, Ehud

    2014-01-01

    groups of central type from such quotients, known as Involutive Yang–Baxter groups. Another motivation for the search of normal Lagrangians comes from a non-commutative generalization of Heisenberg liftings that require normality. Although it is true that symplectic forms over finite nilpotent groups...... always admit Lagrangians, we exhibit an example where none of these subgroups is normal. However, we prove that symplectic forms over nilpotent groups always admit normal Lagrangians if all their p  -Sylow subgroups are of order less than p 8   ....

  7. Functionalized linear and cyclic polyolefins

    Energy Technology Data Exchange (ETDEWEB)

    Tuba, Robert; Grubbs, Robert H.

    2018-02-13

    This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized linear and cyclic polyolefins via olefin metathesis reactions. Polymer products produced via the olefin metathesis reactions of the invention may be utilized for a wide range of materials applications. The invention has utility in the fields of polymer and materials chemistry and manufacture.

  8. Cyclic Processing for Context Fusion

    DEFF Research Database (Denmark)

    Kjærgaard, Mikkel Baun

    2007-01-01

    Many machine-learning techniques use feedback information. However, current context fusion systems do not support this because they constrain processing to be structured as acyclic processing. This paper proposes a generalization which enables the use of cyclic processing in context fusion systems....... A solution is proposed to the inherent problem of how to avoid uncontrollable looping during cyclic processing. The solution is based on finding cycles using graph-coloring and breaking cycles using time constraints....

  9. The symplectic fermion ribbon quasi-Hopf algebra and the SL(2,Z)-action on its centre

    Energy Technology Data Exchange (ETDEWEB)

    Farsad, Vanda

    2017-06-14

    This thesis is concerned with ''N pairs of symplectic fermions'' which are examples of logarithmic conformal field theories in two dimensions. The mathematical language of two-dimensional conformal field theories (on Riemannian surfaces of genus zero) are vertex operator algebras. The representation category of the even part of the symplectic fermion vertex operator super-algebra Rep V{sub ev} is conjecturally a factorisable finite ribbon tensor category. This determines an isomorphism of projective representations between two SL(2,Z)-actions associated to V{sub ev}. The first action is obtained by modular transformations on the space of so-called pseudo-trace functions of a vertex operator algebra. For V{sub ev} this was developed by A.M.Gaberdiel and I. Runkel. For the action one uses that Rep V{sub ev} is conjecturally a factorisable finite ribbon tensor category and thus carries a projective SL(2,Z)-action on a certain Hom-space [Ly1,Ly2,KL]. To do so we calculate the SL(2,Z)-action on the representation category of a general factorisable quasi-Hopf algebras. Then we show that Rep V{sub ev} is conjecturally ribbon equivalent to Rep Q, for Q a factorisable quasi-Hopf algebra, and calculate the SL(2,Z)-action explicitly on Rep Q. The result is that the two SL(2,Z)-action indeed agree. This poses the first example of such comparison for logarithmic conformal field theories.

  10. Anticipatory nausea in cyclical vomiting

    Directory of Open Access Journals (Sweden)

    Fleisher David R

    2005-03-01

    Full Text Available Abstract Background Cyclical Vomiting Syndrome (CVS is characterised by discrete, unexplained episodes of intense nausea and vomiting, and mainly affects children and adolescents. Comprehending Cyclical Vomiting Syndrome requires awareness of the severity of nausea experienced by patients. As a subjective symptom, nausea is easily overlooked, yet is the most distressing symptom for patients and causes many behavioural changes during attacks. Case presentation This first-hand account of one patient's experience of Cyclical Vomiting Syndrome shows how severe nausea contributed to the development of anticipatory nausea and vomiting (ANV, a conditioned response frequently observed in chemotherapy patients. This conditioning apparently worsened the course of the patient's disease. Anticipatory nausea and vomiting has not previously been recognised in Cyclical Vomiting Syndrome, however predictors of its occurrence in oncology patients indicate that it could complicate many cases. Conclusion We suggest a model whereby untreated severe and prolonged nausea provokes anxiety about further cyclical vomiting attacks. This anxiety facilitates conditioning, thus increasing the range of triggers in a self-perpetuating manner. Effective management of the nausea-anxiety feedback loop can reduce the likelihood of anticipatory nausea and vomiting developing in other patients.

  11. On Improvements of Cyclic MUSIC

    Directory of Open Access Journals (Sweden)

    H. Howard Fan

    2005-01-01

    Full Text Available Many man-made signals encountered in communications exhibit cyclostationarity. By exploiting cyclostationarity, cyclic MUSIC has been shown to be able to separate signals with different cycle frequencies, thus, to be able to perform signal selective direction of-arrival (DOA estimation. However, as will be shown in this paper, the DOA estimation of cyclic MUSIC is actually biased. We show in this paper that by properly choosing the frequency for evaluating the steering vector, the bias of DOA estimation can be substantially reduced and the performance can be improved. Furthermore, we propose another algorithm exploiting cyclic conjugate correlation to further improve the performance of DOA estimation. Simulation results show the effectiveness of both of our methods.

  12. Nature of solar cyclicity. I

    Energy Technology Data Exchange (ETDEWEB)

    Romanchuk, P.R.

    1981-01-01

    The report contains a critical survey of work devoted to the study of the nature of solar cyclicity. The inconsistency of the representation of cyclic curves using a frequency spectrum is indicated. The useful contribution of the ideas of Wolf, Newcomb, and Waldmeier to the solution of the problem is noted. Data are cited in favor of the theory of the tidal nature of solar cyclicity developed by the author, which also takes into account the ideas of the above-mentioned authors: the continuous paired and single tidal actions of the planets and the resonance character of this action, thanks to which the approximately 10-year period of action of Jupiter and Saturn is transformed into the 11-year activity cycle.

  13. Nonsurgical treatment of cyclic esotropia.

    Science.gov (United States)

    Voide, Nathalie; Presset, Claudine; Klainguti, Georges; Kaeser, Pierre-François

    2015-04-01

    Cyclic esotropia is characterized by a 24-hour period of straight eye position followed by 24 hours of large-angle esotropia. Possible mechanisms include notably progressive loss of compensation of a latent strabismus. The classic treatment is surgical correction of the angle measured on the days with manifest deviation. We report the first case of cyclic esotropia successfully treated by prismatic correction of the latent strabismus present on "straight" days. Copyright © 2015 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

  14. Synthesis of cyclic tryptathionine peptides.

    Science.gov (United States)

    Zanotti, G; Beijer, B; Wieland, T

    1987-09-01

    The helicity of the tryptathionine moiety of the phallotoxins has been recognized by comparison with cyclic tryptathionine tripeptides. In order to investigate the influence of the configuration of the component amino acids on the conformation of the cyclic peptides, six analogue thioether tripeptides containing L- and D-alanine and L- and D-cysteine, respectively, have been synthesized. The CD spectra of the peptides are very similar to each other, showing mirror images of the CD of phalloidin and, therefore, negative helicity. The spectra of the D-cysteine containing compounds differ from the L-cysteine containing compounds by their weakly positive ellipticity values around 270 nm. The cyclization reaction of Boc-Hpi-D-Ala-D-Cys(STrt)OCH3, along with the cyclic tripeptide, afforded a cyclic hexapeptide by dimerization. The CD spectrum of the dimer is very similar to that of phalloidin, thus pointing to a positive helicity of its two tryptathionine moieties. The dimeric thioether peptide forms a rather strong complex with Cu2+ ions.

  15. A Porism Concerning Cyclic Quadrilaterals

    Directory of Open Access Journals (Sweden)

    Jerzy Kocik

    2013-01-01

    infinite number of cyclic quadrilaterals through four fixed collinear points once one exists. Also, a technique of proving such properties with the use of pseudounitary traceless matrices is presented. A similar property holds for general quadrics as well as for the circle.

  16. Cyclic Voltammograms from First Principles

    DEFF Research Database (Denmark)

    Karlberg, Gustav; Jaramillo, Thomas; Skulason, Egill

    2007-01-01

    for the simple case of electroadsorption and desorption of H. In the following we derive the cyclic voltammogram for H adsorption and desorption on Pt(111) and Pt(100) based solely on density functional theory calculations and standard molecular tables. The method will also be extended to include the potential...

  17. Cyclic AMP relay and cyclic AMP-induced cyclic GMP accumulation during development of Dictyostelium discoideum

    NARCIS (Netherlands)

    Kesbeke, Fanja; Haastert, Peter J.M. van; Schaap, Pauline

    1986-01-01

    Cyclic AMP-induced cAMP and cGMP responses during development of Dictyostelium discoideum were investigated. The cAMP-induced cGMP response is maximal when aggregation is in full progress, and then decreases to about 10% of the maximal level during further multicellular development. The cAMP

  18. The cyclic universe through the origins

    OpenAIRE

    Islam Atef Aly

    2017-01-01

    I report the result of the cyclic universe theory and connect it to the origin of science and God showing some discussions about the cyclic model and the string theory, the cyclic model and the cosmological constant. And discussing the equation of Albert Einstein of the relation between mass and energy.

  19. 40 CFR 721.2120 - Cyclic amide.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Cyclic amide. 721.2120 Section 721... Cyclic amide. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as a cyclic amide (PMN P-92-131) is subject to reporting under this section for the...

  20. Cyclic AMP in cervical mucus.

    Science.gov (United States)

    Póvoa, H; Figueira, D R; Campos da Paz, A; Spichler, E R; Lopes, E R

    1981-01-01

    Cyclic adenosine monophosphate normally stimulates motility of spermatozoa. Its concentration in cervical mucus was studied by an isotopic competitive method in 15 normal women aged between 20 and 50 years. Values were very high, particularly in the periovulatory period, with a mean (+/-SD) value of 167.90 +/- 154.96 nmol/l. These are very high when compared with values in other biological fluids (blood serum and urine).

  1. The cyclical component factor model

    DEFF Research Database (Denmark)

    Dahl, Christian Møller; Hansen, Henrik; Smidt, John

    Forecasting using factor models based on large data sets have received ample attention due to the models' ability to increase forecast accuracy with respect to a range of key macroeconomic variables in the US and the UK. However, forecasts based on such factor models do not uniformly outperform...... the simple autoregressive model when using data from other countries. In this paper we propose to estimate the factors based on the pure cyclical components of the series entering the large data set. Monte Carlo evidence and an empirical illustration using Danish data shows that this procedure can indeed...

  2. Cyclic statistics in rolling bearing diagnosis

    Science.gov (United States)

    Li, Li; Qu, Liangsheng

    2003-10-01

    Mechanical signals with amplitude modulated are characterized by periodic time-varying ensemble statistics and can be considered as cyclostationary. In this paper, the second order cyclic statistics, i.e. cyclic autocorrelation and cyclic spectrum, are introduced. A method of demodulation based on cyclic autocorrelation is derived from a signal model. The modulators and carrier are exhibited, respectively, in low- and high-frequency band of cyclic frequency domain. The three-dimensional spectral correlation figure, which represents cyclic frequency, frequency and spectral correlation strength simultaneously, is developed to express the demodulation results clearly. The method is tested by simulation signal and applied to diagnose rolling bearing faults. It obtained more information than other conventional methods, such as the frequency domain and the envelop detection. Furthermore, its effect is demonstrated by comparing with the wavelet envelope demodulation.

  3. Cyclic Vomiting Syndrome in Children

    Directory of Open Access Journals (Sweden)

    T.V. Sorokman

    2016-08-01

    Full Text Available Introduction. Cyclic vomiting syndrome (CVS — is a fairly common disease of unknown etiology that affects children of all age groups and sometimes adult population and refers to the functional disorders of the gastrointestinal tract. Objective: to evaluate the effectiveness of the usage of Rehydron Optim for oral rehydration therapy in children. Materials and methods. The treatment of 40 children aged 3 to 11 years with CVS (15 persons and primary acetonemic syndrome (25 persons in the period of acetonemic crisis, including 15 boys and 25 girls, was analyzed. All children were observed in the outpatient department of the Regional children’s hospital of Chernivtsi. Diagnosis was established based on anamnesis, clinical and laboratory data. Patients underwent required clinico-biological tests and instrumental examinations. The dynamics of the following syndromes was investigated: pain, vomiting, dehydration and intoxication. Rehydration therapy in all cases was oral with the usage of Rehydron Optim. Results of the study and their discussion. A cyclical vomiting was observed in children with primary acetonemic syndrome with satisfactory condition in attack-free period. Migraine-like headaches prevailed in 36 patients (80 %, and the age of these patients was older than 7 years. Same children had episodes of paroxysmal autonomic failure. Almost all surveyed children had in their family history the risk factors for CVS development. All children had positive dynamics of the main basic clinical manifestations on the background of oral rehydration therapy using Rehydron Optim. Within the 1st day of oral rehydration therapy with Rehydron Optim in children, we have noted a significant decrease in the incidence of lethargy, vomiting, spastic abdominal pain, smell of acetone in the exhaled air (p < 0.05. In children with the I degree of dehydration, clinical signs of dehydration were not seen before the treatment, and children with the II degree had an

  4. Behaviour of Cohesionless Soils During Cyclic Loading

    DEFF Research Database (Denmark)

    Shajarati, Amir; Sørensen, Kris Wessel; Nielsen, Søren Kjær

    Offshore wind turbine foundations are typically subjected to cyclic loading from both wind and waves, which can lead to unacceptable deformations in the soil. However, no generally accepted standardised method is currently available, when accounting for cyclic loading during the design of offshore...... wind turbine foundations. Therefore a literature study is performed in order to investigate existing research treating the behaviour of cohesionless soils, when subjected to cyclic loading. The behaviour of a soil subjected to cyclic loading is found to be dependent on; the relative density, mean...

  5. Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance.

    Directory of Open Access Journals (Sweden)

    Sebastien Hayoz

    Full Text Available Hyperpolarization-activated cyclic nucleotide-modulated (HCN channels control cardiac and neuronal rhythmicity. HCN channels contain cyclic nucleotide-binding domain (CNBD in their C-terminal region linked to the pore-forming transmembrane segment with a C-linker. The C-linker couples the conformational changes caused by the direct binding of cyclic nucleotides to the HCN pore opening. Recently, cyclic dinucleotides were shown to antagonize the effect of cyclic nucleotides in HCN4 but not in HCN2 channels. Based on the structural analysis and mutational studies it has been proposed that cyclic dinucleotides affect HCN4 channels by binding to the C-linker pocket (CLP. Here, we first show that surface plasmon resonance (SPR can be used to accurately measure cyclic nucleotide binding affinity to the C-linker/CNBD of HCN2 and HCN4 channels. We then used SPR to investigate cyclic dinucleotide binding in HCN channels. To our surprise, we detected no binding of cyclic dinucleotides to the isolated monomeric C-linker/CNBDs of HCN4 channels with SPR. The binding of cyclic dinucleotides was further examined with isothermal calorimetry (ITC, which indicated no binding of cyclic dinucleotides to both monomeric and tetrameric C-linker/CNBDs of HCN4 channels. Taken together, our results suggest that interaction of the C-linker/CNBD with other parts of the channel is necessary for cyclic-dinucleotide binding in HCN4 channels.

  6. Hopf and Homoclinic bifurcations on the sliding vector field of switching systems in R3: A case study in power electronics

    Science.gov (United States)

    Cristiano, Rony; Carvalho, Tiago; Tonon, Durval J.; Pagano, Daniel J.

    2017-05-01

    In this paper, Hopf and homoclinic bifurcations that occur in the sliding vector field of switching systems in R3 are studied. In particular, a dc-dc boost converter with sliding mode control and washout filter is analyzed. This device is modeled as a three-dimensional Filippov system, characterized by the existence of sliding movement and restricted to the switching manifold. The operating point of the converter is a stable pseudo-equilibrium and it undergoes a subcritical Hopf bifurcation. Such a bifurcation occurs in the sliding vector field and creates, in this field, an unstable limit cycle. The limit cycle is connected to the switching manifold and disappears when it touches the visible-invisible two-fold point, resulting in a homoclinic loop which itself closes in this two-fold point. The study of these dynamic phenomena that can be found in different power electronic circuits controlled by sliding mode control strategies are relevant from the viewpoint of the global stability and robustness of the control design.

  7. Fractional behaviour at cyclic stretch-bending

    NARCIS (Netherlands)

    Emmens, W.C.; van den Boogaard, Antonius H.; Kazantzis, A.V.; de Hosson, J.Th.M.; Kolleck, R

    2010-01-01

    The fractional behaviour at cyclic stretch-bending has been studied by performing tensile tests at long specimens that are cyclically bent at the same time, on mild steel, dual-phase steel, stainless steel, aluminium and brass. Several types of fracture are observed, these are discussed, as are the

  8. Labor Productivity: Structural Change and Cyclical Dynamics

    NARCIS (Netherlands)

    Baily, M.N.; Bartelsman, E.J.; Haltiwanger, J.

    2001-01-01

    A longstanding issue in empirical economics is the behavior of average labor productivity over the business cycle. This paper provides new insights into the cyclicality of aggregate labor productivity by examining the cyclical behavior of productivity at the plant level as well as the role of

  9. On doubly-cyclic convolutional codes

    NARCIS (Netherlands)

    Gluesing-Luerssen, H; Schmale, W

    Cyclicity of a convolutional code ( CC) is relying on a nontrivial automorphism of the algebra F[x]/(x(n) - 1), where F is a finite field. A particular choice of the data leads to the class of doubly-cyclic CC's. Within this large class Reed-Solomon and BCH convolutional codes can be defined. After

  10. Synthesis of cyclic alpha-MSH peptides

    NARCIS (Netherlands)

    Schaaper, W.M.M.; Adan, R.A.H.; Posthuma, T.A.; Oosterom, J.; Gispen, W.H.; Meloen, R.H.

    1998-01-01

    Cyclic lactam analogs of α-melanocyte stimulating hormone (α-MSH) have been shown to be potent agonists in the frog skin bioassay [Al-Obeidi, F. et al., J. Med. Chem., 32 (1989) 2555], demonstrating melanocortin-1 (MC1) receptor activity. We synthesized cyclic α-MSH(1-13) and α-MSH(4-10) lactam

  11. Synthesis of cyclic α-MSH peptides

    NARCIS (Netherlands)

    Gispen, W.H.; Schaaper, W.M.M..; Adan, R.A.H.; Posthuma, T.A.; Oosterom, J.; Meloen, R.H.

    1998-01-01

    Cyclic lactam analogs of -melanocyte stimulating hormone (-MSH) have been shown to be potent agonists in the frog skin bioassay [Al-Obeidi, F. et al., J. Med. Chem., 32 (1989) 2555], demonstrating melanocortin-1 (MC1) receptor activity. We synthesized cyclic -MSH(1-13) and -MSH(4-10) lactam analogs.

  12. Cyclic vomiting: the pattern and syndrome paradigm.

    Science.gov (United States)

    Li, B U

    1995-01-01

    Although it remains a mysterious disorder since its description over a century ago, cyclic vomiting syndrome appears to be more prevalent than previously thought. With the goal of improving detection of affected children, two quantitative historical criteria-peak intensity > or = 4 emeses/h) and a episode frequency migraine, chronic sinusitis, intracranial neoplasm, anomalies of and mucosal injury to the gastrointestinal tract, urologic abnormalities, and metabolic and endocrine disorders. Because many organic disorders can mimic cyclic vomiting syndrome, a systematic diagnostic evaluation of potential underlying disorders is recommended. The following terminology is proposed: a cyclic pattern is differentiated from a chronic pattern of vomiting on the basis of a higher peak intensity of emesis and lower frequency of episodes; and of those with a cyclic vomiting pattern, an idiopathic subgroup who is not found to have an underlying disorder on diagnostic testing can be labeled as having cyclic vomiting syndrome.

  13. Cyclic Control Optimization for a Smart Rotor

    DEFF Research Database (Denmark)

    Bergami, Leonardo; Henriksen, Lars Christian

    2012-01-01

    bending moment within a rotor revolution. The method is applied to a rotor equipped with trailing edge flaps, and capable of individual blade pitching. Results show that the optimized cyclic control significantly alleviates the load variations from periodic disturbances; the combination of both cyclic......The paper presents a method to determine cyclic control trajectories for a smart rotor undergoing periodic-deterministic load variations. The control trajectories result from a constrained optimization problem, where the cost function to minimize is given by the variation of the blade root flapwise...... flap and pitch allows to reduce the action (and hence the wear) on the pitch actuators, and still to achieve considerable load alleviation....

  14. Driving Force Based Design of Cyclic Distillation

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Fjordbak; Huusom, Jakob Kjøbsted; Abildskov, Jens

    2017-01-01

    Driving force based design is adopted from conventional continuous distillation to cyclic distillation. This leads to a definition of the operating line representation for the cyclic distillation process. A possible realization of the driving force design is presented, which implies operation...... with mixed phase feeds. A range of binary test cases, benzene toluene, methanol water, and ethanol water, are evaluated. The advantage of the design approach in cyclic distillation is shown to be analogous to the advantages obtained in conventional continuous distillation, including a minimal utility...

  15. Genetics Home Reference: cyclic vomiting syndrome

    Science.gov (United States)

    ... without the disorder to experience depression, anxiety, and panic disorder. It is unclear whether these health conditions are directly related to nausea and vomiting. Cyclic vomiting syndrome is often considered to be a variant of ...

  16. Determination of persistent cyclic organochlorine residues in ...

    African Journals Online (AJOL)

    MMLLE) and gas chromatography with an electron capture detector (GC-ECD) and gas chromatograph coupled to a mass spectrometer, was developed for the analysis of cyclic organochlorine pesticides (OCPs) and polychlorinated biphenyls ...

  17. Cyclic universe due to phantom and quintessence

    OpenAIRE

    Gao, Changjun; Lu, Youjun; Shen, You-Gen

    2014-01-01

    We explore a cyclic universe due to phantom and quintessence fields. We find that, in every cycle of the evolution of the universe, the phantom dominates the cosmic early history and quintessence dominates the cosmic far future. In this model of universe, there are infinite cycles of expansion and contraction. Different from the inflationary universe, the corresponding cosmic space-time is geodesically complete and quantum stable. But similar to the Cyclic Model, the flatness problem, the hor...

  18. Cyclic Period in the CBE Model

    CERN Document Server

    Frampton, Paul H

    2016-01-01

    In a cyclic entropy model in which the extroverse is jettisoned at turnaround with a Come Back Empty (CBE) assumption, we address matching of the contaction scale factor $\\hat{a}(t)=f(t_T){a}(t)$ to the expansion scale factor $a(t)$, where $f(t_T)$ is the ratio at turnaround of the introverse to extroverse radii. Such matching is necessary for infinite cyclicity and fixes the CBE period at $\\sim 2.6Ty$.

  19. Modeling Cyclic Variation of Intracranial Pressure

    Science.gov (United States)

    2001-10-25

    demonstrates a cyclic low-frequency variation in the baseline corresponding to the ventilation . As a result, the ICP recording is not similar to the...dilation must be determined. The cyclic variation of intrathoracic pressure during positive pressure ventilation is considered a major causal... mechanism (s) that controls the dynamic characteristics of the ICP recording over the ventilation cycle are up-stream from the pial veins at vascular

  20. Severe congenital cyclic neutropenia: A case report

    OpenAIRE

    Patil, Vidyavathi H.; Hugar, Shivayogi M; Balikai, Girish; Patil, Sudha

    2016-01-01

    Congenital cyclic neutropenia syndrome is a constitutional genetic disorder which is characterized by very low number of neutrophils (neutropenia). Patients suffering from this disorder clinically present with neutropenia at early age, history of recurrent fever, ulcerations in the oral cavity, gingivitis, and other recurrent infections. This paper describes a case report of a child with recurrent mouth ulcers, fever, and later diagnosed with severe congenital cyclic neutropenia. This also em...

  1. Quantum Quasi-Cyclic LDPC Codes

    OpenAIRE

    Hagiwara, Manabu; Imai, Hideki

    2007-01-01

    In this paper, a construction of a pair of "regular" quasi-cyclic LDPC codes as ingredient codes for a quantum error-correcting code is proposed. That is, we find quantum regular LDPC codes with various weight distributions. Furthermore our proposed codes have lots of variations for length, code rate. These codes are obtained by a descrete mathematical characterization for model matrices of quasi-cyclic LDPC codes. Our proposed codes achieve a bounded distance decoding (BDD) bound, or known a...

  2. Response to "Comment on `Application of the extended Lie group analysis to the Hopf functional formulation of the Burgers equation'" [J. Math. Phys. 57, 034102 (2016)

    Science.gov (United States)

    Wacławczyk, Marta; Oberlack, Martin

    2016-03-01

    We address the criticism of Frewer et al. concerning the paper "Application of the extended Lie group analysis to the Hopf functional formulation of the Burgers equation" [J. Math. Phys. 54, 072901 (2013)]. Most importantly, we stress that we never claimed that any new statistical symmetries were found in this paper. The aim of this paper was to apply the Lie group analysis to an equation with functional derivatives and derive invariant solutions for this equation. These results still stand as they are, most important, mathematically correct. We address also other critical statements of Frewer et al. and show that there is a connection between the translational invariance of statistics and transformations of the functional Φ. To sum up, key ideas and fundamental result in the work of Wacławczyk and Oberlack are still unaffected.

  3. Application of the Wiener–Hopf method for describing the propagation of sound in cylindrical and rectangular channels with an impedance jump in the presence of a flow

    Science.gov (United States)

    Sobolev, A. F.; Yakovets, M. A.

    2017-11-01

    Exact solutions to problems of the propagation of acoustic modes in lined channels with an impedance jump in the presence of a uniform flow are constructed. Two problems that can be solved by the Wiener- Hopf method—the propagation of acoustic modes in an infinite cylindrical channel with a transverse impedance jump and the propagation of acoustic modes in a rectangular channel with an impedance jump on one of its walls—are considered. On the channel walls, the Ingard-Myers boundary conditions are imposed and, as an additional boundary condition in the vicinity of the junction of the linings, the condition expressing the finiteness of the acoustic energy. Analytical expressions for the amplitudes of the transmitted and reflected fields are obtained.

  4. Consecutive exotropia following surgically corrected cyclic esotropia.

    Science.gov (United States)

    Post, Joel; Eidsness, Ryan B; Romanchuk, Kenneth G

    2007-01-01

    Cyclic esotropia is a rare form of strabismus consisting of regular intervals of esotropia alternating with periods of orthophoria in a rhythmic/cyclic manner. In the vast majority of cases, surgery appears to permanently correct the esotropia, with no sequelae after years of follow-up. We report a case of consecutive exotropia in a patient five years after bilateral medial rectus recessions for cyclic esotropia. A case report involving review of a clinical chart. A two-year-old male presented with right esotropia and mild amblyopia. He was treated with patching and following resolution of the amblyopia he developed a cyclic esotropia. Surgical correction was performed for the full amount measured on a "manifest" day. Following the surgery, he was orthophoric and demonstrated binocular vision. He remained stable for five years, and then returned with occasional diplopia and an intermittent exotropia. Cyclic esotropia is a rare disorder of ocular motility that spontaneously appears and disappears at regular intervals. After surgical correction, the deviation disappears and recurrence of esotropia is very infrequent. We present the first reported case of consecutive exotropia following surgical correction of a cyclic esotropia.

  5. The evolution of Momordica cyclic peptides.

    Science.gov (United States)

    Mahatmanto, Tunjung; Mylne, Joshua S; Poth, Aaron G; Swedberg, Joakim E; Kaas, Quentin; Schaefer, Hanno; Craik, David J

    2015-02-01

    Cyclic proteins have evolved for millions of years across all kingdoms of life to confer structural stability over their acyclic counterparts while maintaining intrinsic functional properties. Here, we show that cyclic miniproteins (or peptides) from Momordica (Cucurbitaceae) seeds evolved in species that diverged from an African ancestor around 19 Ma. The ability to achieve head-to-tail cyclization of Momordica cyclic peptides appears to have been acquired through a series of mutations in their acyclic precursor coding sequences following recent and independent gene expansion event(s). Evolutionary analysis of Momordica cyclic peptides reveals sites that are under selection, highlighting residues that are presumably constrained for maintaining their function as potent trypsin inhibitors. Molecular dynamics of Momordica cyclic peptides in complex with trypsin reveals site-specific residues involved in target binding. In a broader context, this study provides a basis for selecting Momordica species to further investigate the biosynthesis of the cyclic peptides and for constructing libraries that may be screened against evolutionarily related serine proteases implicated in human diseases. © The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. A Relation Between Quasi-Cyclic Codes and 2-D Cyclic Codes

    OpenAIRE

    Güneri, Cem; Özbudak, Ferruh

    2011-01-01

    International audience; We consider a q-ary quasi-cyclic code C of length m' and index ', where both m and ' are relatively prime to q. If the constituents of C are cyclic codes, we show that C can also be viewed as a 2-D cyclic code of size m *l ' over Fq. If we further assume that m and ' are also coprime to each other, then we easily observe that the code C must be equivalent to a cyclic code. The last fact was proved earlier by Lim using a diff erent approach.

  7. On the problem of the acceleration of particles by the zero-point field of quantum electrodynamics. Exploration with the quantum Einstein-Hopf model

    Energy Technology Data Exchange (ETDEWEB)

    Rueda, A.

    1986-11-11

    Further discussions and detailed calculations on the problem of the spontaneous acceleration of free electromagnetically interacting particles by the zero-point field in the light of a quantum version of the Einstein-Hopf model are presented. It is shown that acceleration occurs if the zero-point field is represented in a time-symmetric fashion within the viewpoint of the Wheeler-Feynman radiant-absorber theory. However, if the zero-point field is represented in the time-asymmetric form, the quantum Einstein-Hopf model yields no translational kinetic-energy growth in disagreement with the previous prediction and with the result of the classical version of the zero-point field in stochastic electrodynamics. The calculations are clear and compelling. Despite that the last no-acceleration result is germane to phenomenological thermodynamics expectations and to a more consistent perspective of quantum theory, the second quantization that leads to the time-symmetric zero-point field yields a conceptually more satisfactory view of this background field which is no longer a free virtual field but becomes a real field which is originated in and is associated with particles. The discussion is based on the different boundary conditions for the electromagnetic-field tensor that the zero-point field (asymmetric vs. symmetric) requires in quantum and in classical theory: time symmetry presupposes a universe that is opaque. If this condition does not hold, we are forced to ordinary time asymmetry and, if a correspondence with quantum electrodynamics is desired, some modification of the hypothesis of stochastic electrodynamics would be required to prevent acceleration. The possible form of that modification is suggested.

  8. Morse Inequalities for Orbifold Cohomology

    DEFF Research Database (Denmark)

    A. Hepworth, Richard

    2009-01-01

    This paper begins the study of Morse theory for orbifolds, or more precisely for differentiable Deligne-Mumford stacks. The main result is an analogue of the Morse inequalities that relates the orbifold Betti numbers of an almost-complex orbifold to the critical points of a Morse function...... on the orbifold. We also show that a generic function on an orbifold is Morse. In obtaining these results we develop for differentiable Deligne-Mumford stacks those tools of differential geometry and topology -- flows of vector fields, the strong topology -- that are essential to the development of Morse theory...... on manifolds....

  9. Mechanical behavior of cyclically loaded PZT

    Energy Technology Data Exchange (ETDEWEB)

    White, G.S.; Hill, M.D.; Freiman, S.W. [National Inst. of Standards and Technology, Gaithersburg, MD (United States); Hwang, C.S. [Seoul National Univ. (Korea, Republic of)

    1994-12-31

    Uses of intelligent materials which involve the application of force or the generation of displacements will require the incorporation of some form of actuator material into the overall structure. Typically, these types of applications will result in the generation of cyclic loads on the actuator; depending upon the specific application, the frequency of the loading could be low, e.g., for positioning components, or relatively high, e.g., for damping out vibrations in machining tools. Nevertheless, the cyclic nature of the loading raises the specter of damage and, ultimately, failure arising from cyclic loading processes which would not be predicted by traditional mechanical properties test methods. It has been found that PZT loaded cyclically sometimes fails at loads below its nominal strength, as measured by traditional, monotonically increasing load tests. Damage mechanisms which come into play as a result of the cyclic loading conditions have been postulated as the reasons for this behavior. Recent work investigating the cyclic loading of a PZT-8 material at resonance frequency determined that microcracks were generated in the high stress region of the material. Recent results demonstrate that macrocrack extension appears to be accompanied by domain reorientation whereas microcracks can propagate around PZT grains without affecting the domains, (2) morphology and distribution of microcracks generated under different loading conditions can change dramatically that the qualitative mechanical response of PZT-8 to cyclic loading appears to be insensitive to grain morphology. The results presented imply that stresses generated at the tips of macrocracks are much larger than those at microcracks, that temperature strongly affects the rate of microcrack generation, and that wide distributions in grain size and the presence of large voids do not necessarily result in increased microcrack generation over that seen in 2 {micro}m grain size, small pore material.

  10. On the equivalence of cyclic and quasi-cyclic codes over finite fields

    Directory of Open Access Journals (Sweden)

    Kenza Guenda

    2017-07-01

    Full Text Available This paper studies the equivalence problem for cyclic codes of length $p^r$ and quasi-cyclic codes of length $p^rl$. In particular, we generalize the results of Huffman, Job, and Pless (J. Combin. Theory. A, 62, 183--215, 1993, who considered the special case $p^2$. This is achieved by explicitly giving the permutations by which two cyclic codes of prime power length are equivalent. This allows us to obtain an algorithm which solves the problem of equivalency for cyclic codes of length $p^r$ in polynomial time. Further, we characterize the set by which two quasi-cyclic codes of length $p^rl$ can be equivalent, and prove that the affine group is one of its subsets.

  11. Cyclic cellular automata in 3D

    Energy Technology Data Exchange (ETDEWEB)

    Reiter, Clifford A., E-mail: reiterc@lafayette.edu [Department of Mathematics, Lafayette College, Easton, PA 18042 (United States)

    2011-09-15

    Highlights: > We explore the self-organization of cyclic cellular automata in 3D. > Von Neumann, Moore and two types of intermediate neighborhoods are investigated. > Random neighborhoods self organize through phases into complex nested structures. > Demons are seen to have many alternatives in 3D. - Abstract: Cyclic cellular automata in two dimensions have long been intriguing because they self organize into spirals and that behavior can be analyzed. The form for the patterns that develop is highly dependent upon the form of the neighborhood. We extend this work to three dimensional cyclic cellular automata and observe self organization dependent upon the neighborhood type. This includes neighborhood types intermediate between Von Neumann and Moore neighborhoods. We also observe that the patterns include nested shells with the appropriate forms but that the nesting is far more complex than the spirals that occur in two dimensions.

  12. The nature of solar cyclicity. I

    Science.gov (United States)

    Romanchuk, P. R.

    1981-02-01

    The report contains a critical survey of work devoted to the study of the nature of solar cyclicity. The inconsistency of the representation of cyclic curves using a frequency spectrum is indicated. The useful contribution of the ideas of Wolf, Newcomb, and Waldmeier to the solution of the problem is noted. Data are cited in favor of the theory of the tidal nature of solar cyclicity developed by the author, which also takes into account the ideas of the above-mentioned authors: the continuous paired and single tidal actions of the planets and the resonance character of this action, thanks to which the approximately 10-year period of action of Jupiter and Saturn is transformed into the 11-year activity cycle.

  13. Cyclic distillation technology - A mini-review

    DEFF Research Database (Denmark)

    Bîldea, Costin Sorin; Pătruţ, Cătălin; Jørgensen, Sten Bay

    2016-01-01

    Process intensification in distillation systems has received much attention during the pastdecades, with the aim of increasing both energy and separation efficiency. Varioustechniques, such as internal heat-integrated distillation, membrane distillation, rotating packedbed, dividing-wall columns...... and reactive distillation were studied and reported in literature. All these techniques employ the conventional continuous counter-current contact of vapor andliquid phases. Cyclic distillation technology is based on an alternative operating mode usingseparate phase movement which leads to key practical...... advantages in both chemical andbiochemical processes. This article provides a mini-review of cyclic distillation technology.The topics covered include the working principle, design and control methods, main benefitsand limitations as well as current industrial applications. Cyclic distillation can...

  14. Cyclic microplasticity factors of some metals

    Energy Technology Data Exchange (ETDEWEB)

    Puskar, A. (University of Transport and Telecommunications, Zilina (Czechoslovakia))

    1983-11-01

    The measurement of the internal friction and the elasticity modulus defect together with a new approximation for evaluating the plastic deformation amplitude from the total deformation amplitude enable the cyclic deformation curves, the changes in hysteresis loop area on increasing the deformation amplitude and many other important characteristics of cyclic microplasticity to be determined during a push-pull type of loading at a frequency of 23kHz on dumb-bell shaped specimens of titanium, molybdenum, niobium and low carbon unalloyed steel.

  15. Towards Optimization of Cyclic Production Systems

    OpenAIRE

    Chauvet, Fabrice; Herrmann, Jeffrey W.; Proth, Jean-Marie

    1999-01-01

    In this paper, the expression "production systems" refers to flow-shops, job-shops, assembly systems, Kanban systems and, in general, to any Discrete Event System (DES) which transforms raw material and/or components into products and/or components. Such a system is said to be cyclic if it provides indefinitely the same sequence of products. A schedule of a cyclic production system is defined as soon as the starting time of each operation on the related resource is known. It has been showed t...

  16. SICLOPPS cyclic peptide libraries in drug discovery.

    Science.gov (United States)

    Tavassoli, Ali

    2017-06-01

    Cyclic peptide libraries have demonstrated significant potential when employed against challenging targets such as protein-protein interactions. While a variety of methods for library generation exist, genetically encoded libraries hold several advantages over their chemically synthesized counterparts; they are more readily accessible and allow straightforward hit deconvolution. One method for the intracellular generation of such libraries is split-intein circular ligation of peptides and proteins (SICLOPPS). Here we detail and discuss the deployment of SICLOPPS libraries for the identification of cyclic peptide inhibitors of a variety of targets. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Severe congenital cyclic neutropenia: A case report.

    Science.gov (United States)

    Patil, Vidyavathi H; Hugar, Shivayogi M; Balikai, Girish; Patil, Sudha

    2016-01-01

    Congenital cyclic neutropenia syndrome is a constitutional genetic disorder which is characterized by very low number of neutrophils (neutropenia). Patients suffering from this disorder clinically present with neutropenia at early age, history of recurrent fever, ulcerations in the oral cavity, gingivitis, and other recurrent infections. This paper describes a case report of a child with recurrent mouth ulcers, fever, and later diagnosed with severe congenital cyclic neutropenia. This also emphasizes the importance of identification of rare causes of immunosuppressive conditions in children presenting with recurrent oral ulcers and poor dental hygiene, to prevent long-term complications of oral cavity and also morbidity and mortality secondary to neutropenic sepsis.

  18. Undrained Cyclic Behaviour of Dense Frederikshavn Sand

    DEFF Research Database (Denmark)

    Nielsen, Søren Kjær; Ibsen, Lars Bo; Sørensen, Kris Wessel

    2013-01-01

    A modified contour diagram is created for the Frederikshavn Sand in the undrained case for a relative density of ID = 80 %. It can be used to estimate the number of cycles to failure for a given combination of pore pressure, average and cyclic load ratio. The diagram is based on a series of undra......A modified contour diagram is created for the Frederikshavn Sand in the undrained case for a relative density of ID = 80 %. It can be used to estimate the number of cycles to failure for a given combination of pore pressure, average and cyclic load ratio. The diagram is based on a series...

  19. Optimization of cyclic operation by recycles

    NARCIS (Netherlands)

    Roffel, B.; Betlem, Bernardus H.L.; Barbosa-Póvoa, A.; Matos, H

    2005-01-01

    The production rate of a batch, fed-batch or cyclic process can be increased, meanwhile providing a high product quality along with an excellent feed exhaustion, by partitioning of the process into two phases: a production and an exhaustion phase. The useful part of the exhaustion phase product is

  20. Cosmology and Cosmogony in a Cyclic Universe

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... In this paper we discuss the properties of the quasi-steady state cosmological model (QSSC) developed in 1993 in its role as a cyclic model of the universe driven by a negative energy scalar field. We discuss the origin of such a scalar field in the primary creation process first described by F. Hoyle & J. V. ...

  1. Cyclic Plastic Deformation and Welding Simulation

    NARCIS (Netherlands)

    Ten Horn, C.H.L.J.

    2003-01-01

    One of the concerns of a fitness for purpose analysis is the quantification of the relevant material properties. It is known from experiments that the mechanical properties of a material can change due to a monotonic plastic deformation or a cyclic plastic deformation. For a fitness for purpose

  2. Cyclic electron flow: facts and hypotheses.

    Science.gov (United States)

    Finazzi, Giovanni; Johnson, Giles N

    2016-09-01

    Over the last 15 years, research into the process of cyclic electron flow in photosynthesis has seen a huge resurgence. Having been considered by some in the early 1990s as a physiologically unimportant artefact, it is now recognised as essential to normal plant growth. Here, we provide an overview of the major developments covered in this special issue of photosynthesis research.

  3. Monopod Bucket Foundations Under Cyclic Lateral Loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo

    2016-01-01

    The monopod bucket foundation has the potential to become a cost-reducing substructure for offshore wind turbines. To avoid problems during the energy converter operation, the long-term effect of cyclic loading must be considered in the design of the foundation. In this paper, a 1-g testing rig...

  4. Monopod bucket foundations under cyclic lateral loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo

    The monopod bucket foundation can be a cost-reducing sub-structure for offshore wind turbines. To avoid problems during the turbine operation, the long-term effect of cyclic loading must be considered in the design of the foundation. In this paper a 1g testing rig is adopted to extend the knowledge...

  5. Cyclic Cushing's syndrome : a clinical challenge

    NARCIS (Netherlands)

    Meinardi, J. R.; Wolffenbuttel, B. H. R.; Dullaart, R. P. F.

    Cyclic Cushing's syndrome (CS) is a rare disorder, characterized by repeated episodes of cortisol excess interspersed by periods of normal cortisol secretion. The so-called cycles of hypercortisolism can occur regularly or irregularly with intercyclic phases ranging from days to years. To formally

  6. Cyclic viscoelastoplasticity of polypropylene/nanoclay composites

    DEFF Research Database (Denmark)

    Drozdov, A.; Christiansen, Jesper de Claville

    2012-01-01

    Observations are reported on isotactic polypropylene/organically modified nanoclay hybrids with concentrations of filler ranging from 0 to 5 wt.% in cyclic tensile tests with a stress–controlled program (oscillations between various maximum stresses and the zero minimum stress). A pronounced effe...

  7. Pseudocontinuation and cyclicity for random power series

    OpenAIRE

    Abakumov, Evgeny; Poltoratski, Alexei

    2007-01-01

    We prove that a random function in the Hardy space $H^2$ is a non-cyclic vector for the backward shift operator almost surely. The question of existence of a local pseudocontinuation for a random analytic function is also studied.

  8. Steady state oxygen reduction and cyclic voltammetry

    DEFF Research Database (Denmark)

    Rossmeisl, Jan; Karlberg, Gustav; Jaramillo, Thomas

    2008-01-01

    The catalytic activity of Pt and Pt3Ni for the oxygen reduction reaction is investigated by applying a Sabatier model based on density functional calculations. We investigate the role of adsorbed OH on the activity, by comparing cyclic voltammetry obtained from theory with previously published ex...

  9. Augmentation Quotients for Real Representation Rings of Cyclic ...

    Indian Academy of Sciences (India)

    29

    Augmentation Quotients for Real Representation Rings of Cyclic Groups. Article Type: Reseach Article. Keywords: cyclic group; real representation; augmentation ideal; augmentation quotient. Corresponding Author: Hang Liu, Ph.D. Shaanxi Normal University. Xi'an, Shaanxi CHINA. Corresponding Author Secondary.

  10. New Correlations Between Monotonic and Cyclic Properties of Metallic Materials

    Science.gov (United States)

    Zonfrillo, Giovanni

    2017-04-01

    Knowledge of the cyclic properties of metallic materials is often critical to correctly design structural components. However, cyclic data are not easily available in the literature, while tensile test data are easier to find in specialized sites or vendor catalogs. In this study, the cyclic strength coefficient and the cyclic strain hardening exponent of the Ramberg-Osgood law were evaluated using exclusively data obtained through monotonic tensile tests. The analyses were carried out on a large set of materials. The database used is composed of 338 alloys, mainly iron alloys, but also titanium and aluminum alloys. New subdivisions of the materials were introduced. Several original relations were suggested to correlate static and cyclic strength parameters. The evaluated values of both cyclic strength coefficient and cyclic strain hardening exponent were compared with experimental values coming from cyclic test, obtaining a satisfactory agreement and a higher accuracy if compared with similar relations found in the literature.

  11. Cyclic Soft Groups and Their Applications on Groups

    Directory of Open Access Journals (Sweden)

    Hacı Aktaş

    2014-01-01

    Full Text Available In crisp environment the notions of order of group and cyclic group are well known due to many applications. In this paper, we introduce order of the soft groups, power of the soft sets, power of the soft groups, and cyclic soft group on a group. We also investigate the relationship between cyclic soft groups and classical groups.

  12. Geometric phases and cyclic isotropic cosmologies

    CERN Document Server

    Bianchi, Leonardo

    2014-01-01

    In the present paper we study the evolution of the modes of a scalar field in a cyclic cosmology. In order to keep the discussion clear, we study the features of a scalar field in a toy model, a Friedman-Robertson-Walker universe with a periodic scale factor, in which the universe expands, contracts and bounces infinite times, in the approximation in which the dynamic features of this universe are driven by some external factor, without the backreaction of the scalar field under study. In particular, we show that particle production exhibits features of the cyclic cosmology in the WKB approximation. Also, by studying the Berry phase of the scalar field, we show that contrarily to what is commonly believed, the scalar field carries information from one bounce to another in the form of a global phase which occurs to be generically non-zero.

  13. Generalized Toeplitz operators and cyclic vectors

    CERN Document Server

    Gassier, G; Zerouali, E H

    2003-01-01

    We give in this paper some asymptotic Von Neumann inequalities for power bounded operators in the class C subrho intersection C sub 1. and some spacial von Neumann inequalities associated with non zero elements of the point spectrum, when it is non void, of generalized Toeplitz operators. Introducing perturbed kernel, we consider classes C sub R which extend the classical classes C subrho. We give results about absolute continuity with respect to the Haar measure for operators in class C sub R intersection C sub 1. This allows us to give new results on cyclic vectors for such operators and provides invariant subspaces for their powers. Relationships between cyclic vectors for T and T* involving generalized Toeplitz operators are given and the commutativity of left brace T right brace', the commutant of T is discussed.

  14. Differential diagnosis of cyclic vomiting syndrome.

    Science.gov (United States)

    Forbes, D

    1995-01-01

    Vomiting is a nonspecific symptom and cyclic vomiting is a symptom complex that may result from a disorder of any major organ system. Children with cyclic vomiting syndrome (CVS) need careful review and investigation at their earliest presentations to exclude potentially lethal abnormalities such as intestinal volvulus, metabolic disorders, and neurologic space-occupying lesions. The range of abnormalities that may present with features consistent with CVS includes gastrointestinal obstructive, inflammatory and motility abnormalities, pancreatic disease, metabolic disease (particularly the amino acid-opathies, organic acidurias, fatty acid oxidation defects, and acute intermittent porphyria), renal disease, epilepsy, migraine, and psychiatric disorders. Careful history taking will usually provide clues to these uncommon problems, but all children should undergo baseline assessment of gastrointestinal morphology and screening tests for renal and metabolic disease.

  15. Standard practice for conducting cyclic humidity exposures

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2001-01-01

    1.1 This test method covers procedures for conducting cyclic humidity tests with a corrosive dip. It sets forth the conditions required in cyclic humidity testing. 1.2 This practice does not prescribe the type of test specimen or exposure periods nor the interpretation to be given to the results. 1.3 The values stated in SI units are to be regarded as the standard. The values given in parentheses are for information only. 1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to consult and establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

  16. Belief Logic Programming with Cyclic Dependencies

    Science.gov (United States)

    Wan, Hui

    Our previous work [26] introduced Belief Logic Programming (BLP), a novel form of quantitative logic programming with correlation of evidence. Unlike other quantitative approaches to logic programming, this new theory is able to provide accurate conclusions in the presence of uncertainty when the sources of information are not independent. However, the semantics defined in [26] is not sufficiently general—it does not allow cyclic dependencies among beliefs, which is a serious limitation of expressive power. This paper extends the semantics of BLP to allow cyclic dependencies. We show that the new semantics is backward compatible with the semantics for acyclic BLP and has the expected properties. The results are illustrated with examples of inference in a simple diagnostic expert system.

  17. Cyclic Nucleotide Signalling in Kidney Fibrosis

    Directory of Open Access Journals (Sweden)

    Elisabeth Schinner

    2015-01-01

    Full Text Available Kidney fibrosis is an important factor for the progression of kidney diseases, e.g., diabetes mellitus induced kidney failure, glomerulosclerosis and nephritis resulting in chronic kidney disease or end-stage renal disease. Cyclic adenosine monophosphate (cAMP and cyclic guanosine monophosphate (cGMP were implicated to suppress several of the above mentioned renal diseases. In this review article, identified effects and mechanisms of cGMP and cAMP regarding renal fibrosis are summarized. These mechanisms include several signalling pathways of nitric oxide/ANP/guanylyl cyclases/cGMP-dependent protein kinase and cAMP/Epac/adenylyl cyclases/cAMP-dependent protein kinase. Furthermore, diverse possible drugs activating these pathways are discussed. From these diverse mechanisms it is expected that new pharmacological treatments will evolve for the therapy or even prevention of kidney failure.

  18. Cyclicality of Wages and Union Power

    DEFF Research Database (Denmark)

    Morin, Annaïg

    2017-01-01

    This paper examines how trade unions shape the volatility of wages over the business cycle. I present a dynamic stochastic model of the labor market that integrates two main features: search frictions and trade unions. Because of search frictions, each job match yields an economic surplus...... that is shared between the worker and the firm. Therefore, I can decompose the volatility of wages into two components: the volatility of the match surplus and the volatility of the worker share of the surplus. Starting from the unions' objective function, I show that under collective wage bargaining, the worker......: the union wage premium fluctuates counter-cyclically, and employment is more cyclical but less persistent when wages are collectively bargained....

  19. Cyclic Triaxial Loading of Cohesionless Silty Sand

    DEFF Research Database (Denmark)

    Sabaliauskas, Tomas; Ibsen, Lars Bo

    2015-01-01

    To engineer efficient structures offshore, we need to extend our knowledge of soil response. Cyclic loading and high water pressure encountered offshore greatly influence cohesionless soil performance. Silty sand from Frederikshavn wind turbine farm was tested using single diameter height samples...... with lubricated, smooth boundary piston heads in a Danish triaxial apparatus. Samples were successfully subjected to loading histories of high complexity. Loading include high strains and stresses, post liquefaction response, transitioning through multiple densities and restoring initial soil properties after...

  20. Optimum Cyclic Redundancy Codes for Noisy Channels

    Science.gov (United States)

    Posner, E. C.; Merkey, P.

    1986-01-01

    Capabilities and limitations of cyclic redundancy codes (CRC's) for detecting transmission errors in data sent over relatively noisy channels (e.g., voice-grade telephone lines or very-high-density storage media) discussed in 16-page report. Due to prevalent use of bytes in multiples of 8 bits data transmission, report primarily concerned with cases in which both block length and number of redundant bits (check bits for use in error detection) included in each block are multiples of 8 bits.

  1. Sequential Annulation Domino Reaction of Sulfur Ylides and α,β-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines.

    Science.gov (United States)

    Jia, Penghao; Huang, You

    2016-05-20

    A sequential annulation domino reaction of sulfur ylides and α,β-unsaturated cyclic ketimines for the construction of cyclic 2-alkenyl aziridines has been developed. Readily accessible starting materials, a one-pot procedure, excellent functional group compatibility, and mild conditions make this transformation a powerful tool for the synthesis of cyclic 2-alkenyl aziridines.

  2. Scale factor duality for conformal cyclic cosmologies

    Energy Technology Data Exchange (ETDEWEB)

    Silva, University Camara da; Lima, A.L. Alves; Sotkov, G.M. [Departamento de Física - CCE,Universidade Federal de Espirito Santo, 29075-900, Vitoria ES (Brazil)

    2016-11-16

    The scale factor duality is a symmetry of dilaton gravity which is known to lead to pre-big-bang cosmologies. A conformal time version of the scale factor duality (SFD) was recently implemented as a UV/IR symmetry between decelerated and accelerated phases of the post-big-bang evolution within Einstein gravity coupled to a scalar field. The problem investigated in the present paper concerns the employment of the conformal time SFD methods to the construction of pre-big-bang and cyclic extensions of these models. We demonstrate that each big-bang model gives rise to two qualitatively different pre-big-bang evolutions: a contraction/expansion SFD model and Penrose’s Conformal Cyclic Cosmology (CCC). A few examples of SFD symmetric cyclic universes involving certain gauged Kähler sigma models minimally coupled to Einstein gravity are studied. We also describe the specific SFD features of the thermodynamics and the conditions for validity of the generalized second law in the case of Gauss-Bonnet (GB) extension of these selected CCC models.

  3. Scale factor duality for conformal cyclic cosmologies

    Science.gov (United States)

    Camara da Silva, U.; Alves Lima, A. L.; Sotkov, G. M.

    2016-11-01

    The scale factor duality is a symmetry of dilaton gravity which is known to lead to pre-big-bang cosmologies. A conformal time version of the scale factor duality (SFD) was recently implemented as a UV/IR symmetry between decelerated and accelerated phases of the post-big-bang evolution within Einstein gravity coupled to a scalar field. The problem investigated in the present paper concerns the employment of the conformal time SFD methods to the construction of pre-big-bang and cyclic extensions of these models. We demonstrate that each big-bang model gives rise to two qualitatively different pre-big-bang evolutions: a contraction/expansion SFD model and Penrose's Conformal Cyclic Cosmology (CCC). A few examples of SFD symmetric cyclic universes involving certain gauged Kähler sigma models minimally coupled to Einstein gravity are studied. We also describe the specific SFD features of the thermodynamics and the conditions for validity of the generalized second law in the case of Gauss-Bonnet (GB) extension of these selected CCC models.

  4. Visualization of cyclic nucleotide dynamics in neurons

    Directory of Open Access Journals (Sweden)

    Kirill eGorshkov

    2014-12-01

    Full Text Available The second messengers cAMP and cGMP transduce many neuromodulatory signals from hormones and neurotransmitters into specific functional outputs. Their production, degradation and signaling are spatiotemporally regulated to achieve high specificity in signal transduction. The development of genetically encodable fluorescent biosensors has provided researchers with useful tools to study these versatile second messengers and their downstream effectors with unparalleled spatial and temporal resolution in cultured cells and living animals. In this review, we introduce the general design of these fluorescent biosensors and describe several of them in more detail. Then we discuss a few examples of using cyclic nucleotide fluorescent biosensors to study regulation of neuronal function and finish with a discussion of advances in the field. Although there has been significant progress made in understanding how the specific signaling of cyclic nucleotide second messengers is achieved, the mechanistic details in complex cell types like neurons are only just beginning to surface. Current and future fluorescent protein reporters will be essential to elucidate the role of cyclic nucleotide signaling dynamics in the functions of individual neurons and their networks.

  5. Cyclic biamperometry at micro-interdigitated electrodes.

    Science.gov (United States)

    Rahimi, Mehdi; Mikkelsen, Susan R

    2011-10-01

    Cyclic biamperometry was studied as an analytical method for use with commercially available, comb-type, coplanar microinterdigitated electrodes (μIDEs), using the ferri-/ferrocyanide redox couple as a model analyte. The μIDEs studied in this work were made of gold that had been deposited onto a Ti/W adhesion layer on borosilicate glass chips and had 5 and 10 μm bands with equal gap sizes. Close proximity of the two working electrodes, and their interdigitation, resulted in signal amplification by redox cycling. Results were compared with those obtained by cyclic voltammetry, where one of the two IDE electrodes was used as the working electrode and external reference and auxiliary electrodes were used. Amplification factors of almost 20 were achieved due to redox cycling. Attempts to apply cyclic voltammetry to the μIDEs, with one of the combs as the working and the other as the auxiliary electrode, were unsuccessful due to corrosion of the auxiliary electrode comb. Results of this study, and the electrochemically unique feature of biamperometry to probe but not change the net contents of the medium under examination, suggest the applicability of scanning biamperometry at μIDEs to the very small volumes and electrochemical cell dimensions that are now of great interest.

  6. Statistical damage constitutive model for rocks subjected to cyclic stress and cyclic temperature

    Science.gov (United States)

    Zhou, Shu-Wei; Xia, Cai-Chu; Zhao, Hai-Bin; Mei, Song-Hua; Zhou, Yu

    2017-10-01

    A constitutive model of rocks subjected to cyclic stress-temperature was proposed. Based on statistical damage theory, the damage constitutive model with Weibull distribution was extended. Influence of model parameters on the stress-strain curve for rock reloading after stress-temperature cycling was then discussed. The proposed model was initially validated by rock tests for cyclic stress-temperature and only cyclic stress. Finally, the total damage evolution induced by stress-temperature cycling and reloading after cycling was explored and discussed. The proposed constitutive model is reasonable and applicable, describing well the stress-strain relationship during stress-temperature cycles and providing a good fit to the test results. Elastic modulus in the reference state and the damage induced by cycling affect the shape of reloading stress-strain curve. Total damage induced by cycling and reloading after cycling exhibits three stages: initial slow increase, mid-term accelerated increase, and final slow increase.

  7. Cyclic AMP receptor protein-aequorin molecular switch for cyclic AMP.

    Science.gov (United States)

    Scott, Daniel; Hamorsky, Krystal Teasley; Ensor, C Mark; Anderson, Kimberly W; Daunert, Sylvia

    2011-03-16

    Molecular switches are designer molecules that combine the functionality of two individual proteins into one, capable of manifesting an "on/off" signal in response to a stimulus. These switches have unique properties and functionalities and thus, can be employed as nanosensors in a variety of applications. To that end, we have developed a bioluminescent molecular switch for cyclic AMP. Bioluminescence offers many advantages over fluorescence and other detection methods including the fact that there is essentially zero background signal in physiological fluids, allowing for more sensitive detection and monitoring. The switch was created by combining the properties of the cyclic AMP receptor protein (CRP), a transcriptional regulatory protein from E. Coli that binds selectively to cAMP with those of aequorin, a bioluminescent photoprotein native of the jellyfish Aequorea victoria . Genetic manipulation to split the genetic coding sequence of aequorin in two and genetically attach the fragments to the N and C termini of CRP resulted in a hybrid protein molecular switch. The conformational change experienced by CRP upon the binding of cyclic AMP is suspected to result in the observed loss of the bioluminescent signal from aequorin. The "on/off" bioluminescence can be modulated by cyclic AMP over a range of several orders of magnitude in a linear fashion in addition to the capacity to detect changes in cellular cyclic AMP of intact cells exposed to different external stimuli without the need to lyse the cells. We envision that the molecular switch could find applications in vitro as well as In Vivo cyclic AMP detection and/or imaging.

  8. Numerical Simulation of Cyclic Thermodynamic Processes

    DEFF Research Database (Denmark)

    Andersen, Stig Kildegård

    2006-01-01

    This thesis is on numerical simulation of cyclic thermodynamic processes. A modelling approach and a method for finding periodic steady state solutions are described. Examples of applications are given in the form of four research papers. Stirling machines and pulse tube coolers are introduced......, compressible flow in one space dimension is presented. The implementation produces models where all the equations, which are on a form that should be understandable to someone with a background in engineering thermodynamics, can be accessed and modified individually. The implementation was designed to make...

  9. Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids

    Directory of Open Access Journals (Sweden)

    Seyeon Park

    2016-11-01

    Full Text Available Diverse flavonoids are abundant in dietary food constituents and possess useful biological activities. However, some flavonoids have limited bioavailability due to their low solubility in water. As an important approach to enhance aqueous solubility, inclusion of hydrophobic guest molecules in hydrophilic hosts such as cyclic glucans has been used. This review summarizes applications of β-cyclodextrin, synthetic β-cyclodextrin derivatives, and newly synthesized derivatives of cyclosophoraoses as complexing agents to enhance the bioavailability of flavonoids such as baicalein, kaempferol, and naphthoflavones.

  10. Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

    National Research Council Canada - National Science Library

    Rachael P. Norris; William J. Ratzan; Marina Freudzon; Lisa M. Mehlmann; Judith Krall; Matthew A. Movsesian; Huanchen Wang; Hengming Ke; Viacheslav O. Nikolaev; Laurinda A. Jaffe

    2009-01-01

    .... Using FRET-based cyclic nucleotide sensors in follicle-enclosed mouse oocytes, we find that cGMP passes through gap junctions into the oocyte, where it inhibits the hydrolysis of cAMP by the phosphodiesterase PDE3A...

  11. Investigation of Cyclic Deformation and Fatigue of Polycrystalline Cu under Pure Compression Cyclic Loading Conditions

    Science.gov (United States)

    Hsu, Tzu-Yin Jean

    It is commonly accepted that fatigue crack is initiated under tensile fatigue stresses. However, practical examples demonstrate that cracks may also initiate under pure compressive fluctuating loads such as the failures observed in aircraft landing gear frames. However, the mechanism of such failures is rarely investigated. Furthermore, knowledge on cyclic deformation response under pure compressive fatigue condition is also very limited or non-existent. Our recent work already verified that fatigue cracks may nucleate from stress concentration sites under pure compression fatigue, but whether or not a form of stress concentration is always needed to initiate a crack under pure compression fatigue remains uncertain. In this study, compression fatigue tests under different peak stresses were carried out on smooth bars of fully annealed OFHC Copper. The purpose of these tests is to investigate not only the cyclic deformation response but also the possibility of crack nucleation without the stress concentrator. Results showed that overall the cyclic stress-strain response and microstructural evolution of OFHC Copper under pure compression fatigue exhibits rather dissimilar behaviour compared to those under symmetrical fatigue. The specimens hardened rapidly within 10 cycles under pure compression fatigue unlike the gradual cyclic hardening behaviour in symmetrical fatigue with the same peak stress amplitude. Compressive cyclic creep behaviour was also observed under the same testing conditions. Moreover, unlike conventional tension-compression fatigue, only moderate slip activity was detectable on the surface instead of typical PSB features detected from TEM observations. The surface observations has revealed that surface slip bands did not increase in number nor did they become more pronounced in height with increasing number of cycles. In addition, surface roughening by grain boundary extrusion was detected to become more severe as the cycling progressed. Therefore

  12. Rf cavity primer for cyclic proton accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, J.E.

    1988-04-01

    The purpose of this note is to describe the electrical and mechanical properites of particle accelerator rf cavities in a manner which will be useful to physics and engineering graduates entering the accelerator field. The discussion will be limited to proton (or antiproton) synchrotron accelerators or storage rings operating roughly in the range of 20 to 200 MHz. The very high gradient, fixed frequency UHF or microwave devices appropriate for electron machines and the somewhat lower frequency and broader bandwidth devices required for heavy ion accelerators are discussed extensively in other papers in this series. While it is common pratice to employ field calculation programs such as SUPERFISH, URMEL, or MAFIA as design aids in the development of rf cavities, we attempt here to elucidate various of the design parameters commonly dealt with in proton machines through the use of simple standing wave coaxial resonator expressions. In so doing, we treat only standing wave structures. Although low-impedance, moderately broad pass-band travelling wave accelerating systems are used in the CERN SPS, such systems are more commonly found in linacs, and they have not been used widely in large cyclic accelerators. Two appendices providing useful supporting material regarding relativistic particle dynamics and synchrotron motion in cyclic accelerators are added to supplement the text.

  13. Effect of registration on cyclical kinematic data.

    Science.gov (United States)

    Crane, Elizabeth A; Cassidy, Ruth B; Rothman, Edward D; Gerstner, Geoffrey E

    2010-08-26

    Given growing interest in functional data analysis (FDA) as a useful method for analyzing human movement data, it is critical to understand the effects of standard FDA procedures, including registration, on biomechanical analyses. Registration is used to reduce phase variability between curves while preserving the individual curve's shape and amplitude. The application of three methods available to assess registration could benefit those in the biomechanics community using FDA techniques: comparison of mean curves, comparison of average RMS values, and assessment of time-warping functions. Therefore, the present study has two purposes. First, the necessity of registration applied to cyclical data after time normalization is assessed. Second, we illustrate the three methods for evaluating registration effects. Masticatory jaw movements of 22 healthy adults (2 males, 21 females) were tracked while subjects chewed a gum-based pellet for 20s. Motion data were captured at 60 Hz with two gen-locked video cameras. Individual chewing cycles were time normalized and then transformed into functional observations. Registration did not affect mean curves and warping functions were linear. Although registration decreased the RMS, indicating a decrease in inter-subject variability, the difference was not statistically significant. Together these results indicate that registration may not always be necessary for cyclical chewing data. An important contribution of this paper is the illustration of three methods for evaluating registration that are easy to apply and useful for judging whether the extra data manipulation is necessary. 2010 Elsevier Ltd. All rights reserved.

  14. A cyclically actuated electrolytic drug delivery device

    KAUST Repository

    Yi, Ying

    2015-01-01

    This work, focusing on an implantable drug delivery system, presents the first prototype electrolytic pump that combines a catalytic reformer and a cyclically actuated mode. These features improve the release performance and extend the lifetime of the device. Using our platinum (Pt)-coated carbon fiber mesh that acts as a catalytic reforming element, the cyclical mode is improved because the faster recombination rate allows for a shorter cycling time for drug delivery. Another feature of our device is that it uses a solid-drug-in-reservoir (SDR) approach, which allows small amounts of a solid drug to be dissolved in human fluid, forming a reproducible drug solution for long-term therapies. We have conducted proof-of-principle drug delivery studies using such an electrolytic pump and solvent blue 38 as the drug substitute. These tests demonstrate power-controlled and pulsatile release profiles of the chemical substance, as well as the feasibility of this device. A drug delivery rate of 11.44 ± 0.56 μg min-1 was achieved by using an input power of 4 mW for multiple pulses, which indicates the stability of our system. © The Royal Society of Chemistry 2015.

  15. On cyclic codes of composite length and the minimal distance

    OpenAIRE

    Xiong, Maosheng

    2017-01-01

    In an interesting paper Professor Cunsheng Ding provided three constructions of cyclic codes of length being a product of two primes. Numerical data shows that many codes from these constructions are best cyclic codes of the same length and dimension over the same finite field. However, not much is known about these codes. In this paper we explain some of the mysteries of the numerical data by developing a general method on cyclic codes of composite length and on estimating the minimal distan...

  16. A map of the human neocortex showing the estimated overall myelin content of the individual architectonic areas based on the studies of Adolf Hopf.

    Science.gov (United States)

    Nieuwenhuys, Rudolf; Broere, Cees A J

    2017-01-01

    During the period extending from 1910 to 1970, Oscar and Cécile Vogt and their numerous collaborators published a large number of myeloarchitectonic studies on the cortex of the various lobes of the human cerebrum. In a previous publication [Nieuwenhuys et al (Brain Struct Funct 220:2551-2573, 2015; Erratum in Brain Struct Funct 220: 3753-3755, 2015)], we used the data provided by the Vogt-Vogt school for the composition of a myeloarchitectonic map of the entire human neocortex. Because these data were derived from many different brains, a standard brain had to be introduced to which all data available could be transferred. As such the Colin 27 structural scan, aligned to the MNI305 template was selected. The resultant map includes 180 myeloarchitectonic areas, 64 frontal, 30 parietal, 6 insular, 17 occipital and 63 temporal. Here we present a supplementary map in which the overall density of the myelinated fibers in the individual architectonic areas is indicated, based on a meta-analysis of data provided by Adolf Hopf, a prominent collaborator of the Vogts. This map shows that the primary sensory and motor regions are densely myelinated and that, in general, myelination decreases stepwise with the distance from these primary regions. The map also reveals the presence of a number of heavily myelinated formations, situated beyond the primary sensory and motor domains, each consisting of two or more myeloarchitectonic areas. These formations were provisionally designated as the orbitofrontal, intraparietal, posterolateral temporal, and basal temporal dark clusters. Recently published MRI-based in vivo myelin content mappings show, with regard to the primary sensory and motor regions, a striking concordance with our map. As regards the heavily myelinated clusters shown by our map, scrutiny of the current literature revealed that correlates of all of these clusters have been identified in in vivo structural MRI studies and appear to correspond either entirely or

  17. Estrous Cyclicity in Mice During Simulated Weightlessness

    Science.gov (United States)

    Moyer, E. L.; Talyansky, Y.; Scott, R. T.; Tash, J. S.; Christenson, L. K.; Alwood, J. S.; Ronca, A. E.

    2017-01-01

    Hindlimb unloading (HU) is a rodent model system used to simulate weightlessness experienced in space. However, some effects of this approach on rodent physiology are under-studied, specifically the effects on ovarian estrogen production which drives the estrous cycle. To resolve this deficiency, we conducted a ground-based validation study using the HU model, while monitoring estrous cycles in 16-weeks-old female C57BL6 mice. Animals were exposed to HU for 12 days following a 3 day HU cage acclimation period, and estrous cycling was analyzed in HU animals (n=22), normally loaded HU Cage Pair-Fed controls (CPF; n=22), and Vivarium controls fed ad libitum (VIV; n=10). Pair feeding was used to control for potential nutritional deficits on ovarian function. Vaginal cells were sampled daily in all mice via saline lavage. Cells were dried and stained with crystal violet, and the smears evaluated using established vaginal cytology techniques by two individuals blinded to the animal treatment group. Estrous cyclicity was disrupted in nearly all HU and CPF mice, while those maintained in VIV had an average normal cycle length of 4.8+/- 0.5 days, with all stages in the cycle visibly observed. CPF and HU animals arrested in the diestrous phase, which precedes the pre-ovulatory estrogen surge. Additionally, infection-like symptoms characterized by vaginal discharge and swelling arose in several HU animals, which we suspect was due to an inability of these mice to properly groom themselves, and/or due to the change in the gravity vector relative to the vaginal opening, which prevented drainage of the lavage solution. Pair-feeding resulted in similar weight gains of HU and CPF (1.5% vs 3.0%, respectively). The current results indicate that pair-feeding controlled weight gain and that the HU cage alone influenced estrous cyclicity. Thus, longer acclimation needs to be tested to determine if and when normal estrous cycling resumes in non-loaded mice in HU cages prior to HU

  18. Estrous Cyclicity of Mice During Simulated Weightlessness

    Science.gov (United States)

    Moyer, Eric; Talyansky, Yuli; Scott, Ryan; Tash, Joseph; Christenson, Lane; Alwood, Joshua; Ronca, April

    2017-01-01

    Hindlimb unloading (HU) is a rodent model system used to simulate weightlessness experienced in space. However, some effects of this approach on rodent physiology are under-studied, specifically the effects on ovarian estrogen production which drives the estrous cycle. To resolve this deficiency, we conducted a ground-based validation study using the HU model, while monitoring estrous cycles in 16-weeks-old female C57BL6 mice. Animals were exposed to HU for 12 days following a 3 day HU cage acclimation period, and estrous cycling was analyzed in HU animals (n22), normally loaded HU Cage Pair-Fed controls (CPF; n22), and Vivarium controls fed ad libitum (VIV; n10). Pair feeding was used to control for potential nutritional deficits on ovarian function. Vaginal cells were sampled daily in all mice via saline lavage. Cells were dried and stained with crystal violet, and the smears evaluated using established vaginal cytology techniques by two individuals blinded to the animal treatment group. Estrous cyclicity was disrupted in nearly all HU and CPF mice, while those maintained in VIV had an average normal cycle length of 4.8 0.5 days, with all stages in the cycle visibly observed. CPF and HU animals arrested in the diestrous phase, which precedes the pre-ovulatory estrogen surge. Additionally, infection-like symptoms characterized by vaginal discharge and swelling arose in several HU animals, which we suspect was due to an inability of these mice to properly groom themselves, andor due to the change in the gravity vector relative to the vaginal opening, which prevented drainage of the lavage solution. Pair-feeding resulted in similar weight gains of HU and CPF (1.5 vs 3.0, respectively). The current results indicate that pair-feeding controlled weight gain and that the HU cage alone influenced estrous cyclicity. Thus, longer acclimation needs to be tested to determine if and when normal estrous cycling resumes in non-loaded mice in HU cages prior to HU testing. Future

  19. Microplastic deformation of polycrystals during cyclic loading

    Science.gov (United States)

    Dudarev, E. F.; Pochivalova, G. P.; Nikitina, N. V.

    1990-03-01

    A model of microplastic deformation of polycrystals during zero-start cyclic loading with tensions lower than the yield strength is proposed according to which during cycling, thermally activated movement of dislocations occurs under conditions of stress relaxation. Based on this model and the statistical theory of polycrystalline microdeformation, the accumulation of microplastic deformation is theoretically described as a function of the number of loading cycles and the stress amplitudes. It is theoretically proved that in the cycling process the microplastic deformation that accumulates over one cycle decreases as the number of cycles increases; up to the macroscopic elastic limit it is independent of the stress amplitude, and then sharply increases. Agreement of the theory with experimental data for spring alloys is observed in the density of mobile dislocations, which decreases during cycling.

  20. Protein Misfolding Cyclic Amplification of Infectious Prions.

    Science.gov (United States)

    Moda, Fabio

    2017-01-01

    Transmissible spongiform encephalopathies, or prion diseases, are a group of incurable disorders caused by the accumulation of an abnormally folded prion protein (PrP Sc ) in the brain. According to the "protein-only" hypothesis, PrP Sc is the infectious agent able to propagate the disease by acting as a template for the conversion of the correctly folded prion protein (PrP C ) into the pathological isoform. Recently, the mechanism of PrP C conversion has been mimicked in vitro using an innovative technique named protein misfolding cyclic amplification (PMCA). This technology represents a great tool for studying diverse aspects of prion biology in the field of basic research and diagnosis. Moreover, PMCA can be expanded for the study of the misfolding process associated to other neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and frontotemporal lobar degeneration. © 2017 Elsevier Inc. All rights reserved.

  1. A Cyclical Nurse Schedule Using Goal Programming

    Directory of Open Access Journals (Sweden)

    Ruzzakiah Jenal

    2011-11-01

    Full Text Available Scheduling is a very tedious task in organizations where duty is around the clock. Constructing timetable for nurses in hospital is one of the challenging jobs for the head nurse or nurse manager. It requires a lot of time to spend for generating a good and fair timetable. Thus, in this study, we propose a cyclical nurse scheduling model using a 0-1 goal programming that would help the head nurse or nurse manager to have less effort on building new schedules periodically. The proposed model satisfies the stated hospital’s policies and the nurses’ preferences. The result obtained from this model gives an optimal solution where all goals are achieved. The model also provides an unbiased way of scheduling the nurses and thus leads to an overall higher satisfaction and fairness to the nurses and the hospital management.

  2. Pyroelectric Harvesters for Generating Cyclic Energy

    Directory of Open Access Journals (Sweden)

    Chun-Ching Hsiao

    2015-04-01

    Full Text Available Pyroelectric energy conversion is a novel energy process which directly transforms waste heat energy from cyclic heating into electricity via the pyroelectric effect. Application of a periodic temperature profile to pyroelectric cells is necessary to achieve temperature variation rates for generating an electrical output. The critical consideration in the periodic temperature profile is the frequency or work cycle which is related to the properties and dimensions of the air layer; radiation power and material properties, as well as the dimensions and structure of the pyroelectric cells. This article aims to optimize pyroelectric harvesters by matching all these requirements. The optimal induced charge per period increases about 157% and the efficient period band decreases about 77%, when the thickness of the PZT cell decreases from 200 μm to 50 μm, about a 75% reduction. Moreover, when using the thinner PZT cell for harvesting the pyroelectric energy it is not easy to focus on a narrow band with the efficient period. However, the optimal output voltage and stored energy per period decrease about 50% and 74%, respectively, because the electrical capacitance of the 50 μm thick pyroelectric cell is about four times greater than that of the 200 μm thick pyroelectric cell. In addition, an experiment is used to verify that the work cycle to be able to critically affect the efficiency of PZT pyroelectric harvesters. Periods in the range between 3.6 s and 12.2 s are useful for harvesting thermal cyclic energy by pyroelectricity. The optimal frequency or work cycle can be applied in the design of a rotating shutter in order to control the heated and unheated periods of the pyroelectric cells to further enhance the amount of stored energy.

  3. Structure and stability of spiro-cyclic water clusters

    Indian Academy of Sciences (India)

    Administrator

    Abstract. The structure and stability of spiro-cyclic water clusters containing up to 32 water molecules have been investigated at different levels of theory. Although there exist minima lower in energy than these spiro-cyclic clusters, calculations at the Hartree–Fock level, density functional theory using B3LYP parametrization ...

  4. Improvements of cyclic somatic embryogenesis of cassava (Manihot esculenta Crantz).

    NARCIS (Netherlands)

    Raemakers, C.J.J.M.; Schavemaker, C.M.; Jacobsen, E.; Visser, R.G.F.

    1993-01-01

    In cassava a cyclic system of somatic embryogenesis was developed. Primary (torpedo shaped or germinated) embryos, originating from leaf lobes, could only be obtained after culture on solid medium. Cyclic embryos, originating from embryos, could be obtained in both liquid and on solid medium. The

  5. Supplementary Material for: The arabidopsis cyclic nucleotide interactome

    KAUST Repository

    Donaldson, Lara

    2016-01-01

    Abstract Background Cyclic nucleotides have been shown to play important signaling roles in many physiological processes in plants including photosynthesis and defence. Despite this, little is known about cyclic nucleotide-dependent signaling mechanisms in plants since the downstream target proteins remain unknown. This is largely due to the fact that bioinformatics searches fail to identify plant homologs of protein kinases and phosphodiesterases that are the main targets of cyclic nucleotides in animals. Methods An affinity purification technique was used to identify cyclic nucleotide binding proteins in Arabidopsis thaliana. The identified proteins were subjected to a computational analysis that included a sequence, transcriptional co-expression and functional annotation analysis in order to assess their potential role in plant cyclic nucleotide signaling. Results A total of twelve cyclic nucleotide binding proteins were identified experimentally including key enzymes in the Calvin cycle and photorespiration pathway. Importantly, eight of the twelve proteins were shown to contain putative cyclic nucleotide binding domains. Moreover, the identified proteins are post-translationally modified by nitric oxide, transcriptionally co-expressed and annotated to function in hydrogen peroxide signaling and the defence response. The activity of one of these proteins, GLYGOLATE OXIDASE 1, a photorespiratory enzyme that produces hydrogen peroxide in response to Pseudomonas, was shown to be repressed by a combination of cGMP and nitric oxide treatment. Conclusions We propose that the identified proteins function together as points of cross-talk between cyclic nucleotide, nitric oxide and reactive oxygen species signaling during the defence response.

  6. A Sensitive Cyclic Nucleotide Phosphodiesterase Assay for Transient Enzyme Kinetics

    NARCIS (Netherlands)

    Lookeren Campagne, Michiel M. van; Haastert, Peter J.M. van

    1983-01-01

    A new assay for cyclic nucleotide phosphodiesterase has been developed by using reverse-phase column chromatography for the separation of product and substrate of the enzymatic reaction. The polar 5'-nucleotides are not retarded by the column, while the more lipophilic cyclic nucleotides bind to the

  7. Classifying spaces with virtually cyclic stabilizers for linear groups

    DEFF Research Database (Denmark)

    Degrijse, Dieter Dries; Köhl, Ralf; Petrosyan, Nansen

    2015-01-01

    We show that every discrete subgroup of GL(n, ℝ) admits a finite-dimensional classifying space with virtually cyclic stabilizers. Applying our methods to SL(3, ℤ), we obtain a four-dimensional classifying space with virtually cyclic stabilizers and a decomposition of the algebraic K-theory of its...

  8. Evaluating cyclic fatigue of sealants during outdoor testing

    Science.gov (United States)

    R. Sam Williams; Steven Lacher; Corey Halpin; Christopher White

    2009-01-01

    A computer-controlled test apparatus (CCTA) and other instrumentation for subjecting sealant specimens to cyclic fatigue during outdoor exposure was developed. The CCTA enables us to use weather-induced conditions to cyclic fatigue specimens and to conduct controlled tests in-situ during the outdoor exposure. Thermally induced dimensional changes of an aluminum bar...

  9. The antimycin A-sensitive pathway of cyclic electron flow

    DEFF Research Database (Denmark)

    Labs, Mathias; Rühle, Thilo; Leister, Dario Michael

    2016-01-01

    Cyclic electron flow has puzzled and divided the field of photosynthesis researchers for decades. This mainly concerns the proportion of its overall contribution to photosynthesis, as well as its components and molecular mechanism. Yet, it is irrefutable that the absence of cyclic electron flow has...

  10. Cyclic imines evaluation in European commercial shellfish samples

    DEFF Research Database (Denmark)

    Rambla, Maria; Fernandez-Tejedor, Margarita; Miles, Christopher O.

    Cyclic imines constitute a quite recently discovered group of marine biotoxins that act on neural receptors and that bioaccumulate in seafood. They are grouped together due to the imino group functioning as their common pharmacore, responsible for acute neurotoxicity in mice. Cyclic imines have n...

  11. Phenomenon of low-alloy steel parametrization transformation at cyclic loading in low-cyclic area

    Science.gov (United States)

    Shipachev, A. M.; Nazarova, M. N.

    2017-10-01

    Following the results of measurements of hardness, magnetizing force and the rate of ultrasonic longitudinal waves of 09G2S steel samples at various cyclic operating time values, there is a phenomenon of transformation from the normal law of speed distribution of these parameters in power-mode distribution. It shows the submission of the behavior of metal as a complex system to the theory of the self-organized criticality.

  12. Cyclic response and early damage evolution in multiaxial cyclic loading of 316L austenitic steel

    Czech Academy of Sciences Publication Activity Database

    Mazánová, Veronika; Škorík, Viktor; Kruml, Tomáš; Polák, Jaroslav

    2017-01-01

    Roč. 100, JUL (2017), s. 466-476 ISSN 0142-1123 R&D Projects: GA MŠk LM2015069; GA MŠk(CZ) LQ1601; GA ČR(CZ) GA13-23652S; GA ČR GA15-08826S Institutional support: RVO:68081723 Keywords : 316L steel * Crack initiation * Cyclic plasticity * Damage mechanism * Multiaxial straining Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 2.899, year: 2016

  13. Spatial Non-Cyclic Geometric Phase in Neutron Interferometry.

    Science.gov (United States)

    Filipp, Stefan; Hasegawa, Yuji; Loidl, Rudolf; Rauch, Helmut

    2005-01-01

    We present a split-beam neutron interferometric experiment to test the non-cyclic geometric phase tied to the spatial evolution of the system: the subjacent two-dimensional Hilbert space is spanned by the two possible paths in the interferometer and the evolution of the state is controlled by phase shifters and absorbers. A related experiment was reported previously by some of the authors to verify the cyclic spatial geometric phase. The interpretation of this experiment, namely to ascribe a geometric phase to this particular state evolution, has met severe criticism. The extension to non-cyclic evolution manifests the correctness of the interpretation of the previous experiment by means of an explicit calculation of the non-cyclic geometric phase in terms of paths on the Bloch-sphere. The theoretical treatment comprises the cyclic geometric phase as a special case, which is confirmed by experiment.

  14. The elimination of hierarchy in a completely cyclic competition system

    Science.gov (United States)

    Li, Yongming; Dong, Linrong; Yang, Guangcan

    2012-01-01

    Interactions among competing units are crucial to maintaining biodiversity, and non-hierarchical interactions can promote biodiversity in cyclic competing systems. In the present study, we explore the role of hierarchical interactions, existing ubiquitously in reality, in the co-evolution of a cyclic competing system. In systems composed of cyclic competing species with hierarchy interactions in which one predator species has more than one prey, we find that hierarchy disappears in a rather short evolving time. In the process of co-evolution, a hierarchical competing system tends to transit to a cyclic non-hierarchical competing system described by the rock-paper-scissors game. In other words, the cyclic competing interactions appear to eradicate hierarchy. This conclusion is analyzed by a mean-field approach and is tested by stochastic simulations.

  15. History-independent cyclic response of nanotwinned metals

    Science.gov (United States)

    Pan, Qingsong; Zhou, Haofei; Lu, Qiuhong; Gao, Huajian; Lu, Lei

    2017-11-01

    Nearly 90 per cent of service failures of metallic components and structures are caused by fatigue at cyclic stress amplitudes much lower than the tensile strength of the materials involved. Metals typically suffer from large amounts of cumulative, irreversible damage to microstructure during cyclic deformation, leading to cyclic responses that are unstable (hardening or softening) and history-dependent. Existing rules for fatigue life prediction, such as the linear cumulative damage rule, cannot account for the effect of loading history, and engineering components are often loaded by complex cyclic stresses with variable amplitudes, mean values and frequencies, such as aircraft wings in turbulent air. It is therefore usually extremely challenging to predict cyclic behaviour and fatigue life under a realistic load spectrum. Here, through both atomistic simulations and variable-strain-amplitude cyclic loading experiments at stress amplitudes lower than the tensile strength of the metal, we report a history-independent and stable cyclic response in bulk copper samples that contain highly oriented nanoscale twins. We demonstrate that this unusual cyclic behaviour is governed by a type of correlated ‘necklace’ dislocation consisting of multiple short component dislocations in adjacent twins, connected like the links of a necklace. Such dislocations are formed in the highly oriented nanotwinned structure under cyclic loading and help to maintain the stability of twin boundaries and the reversible damage, provided that the nanotwins are tilted within about 15 degrees of the loading axis. This cyclic deformation mechanism is distinct from the conventional strain localizing mechanisms associated with irreversible microstructural damage in single-crystal, coarse-grained, ultrafine-grained and nanograined metals.

  16. History-independent cyclic response of nanotwinned metals.

    Science.gov (United States)

    Pan, Qingsong; Zhou, Haofei; Lu, Qiuhong; Gao, Huajian; Lu, Lei

    2017-11-09

    Nearly 90 per cent of service failures of metallic components and structures are caused by fatigue at cyclic stress amplitudes much lower than the tensile strength of the materials involved. Metals typically suffer from large amounts of cumulative, irreversible damage to microstructure during cyclic deformation, leading to cyclic responses that are unstable (hardening or softening) and history-dependent. Existing rules for fatigue life prediction, such as the linear cumulative damage rule, cannot account for the effect of loading history, and engineering components are often loaded by complex cyclic stresses with variable amplitudes, mean values and frequencies, such as aircraft wings in turbulent air. It is therefore usually extremely challenging to predict cyclic behaviour and fatigue life under a realistic load spectrum. Here, through both atomistic simulations and variable-strain-amplitude cyclic loading experiments at stress amplitudes lower than the tensile strength of the metal, we report a history-independent and stable cyclic response in bulk copper samples that contain highly oriented nanoscale twins. We demonstrate that this unusual cyclic behaviour is governed by a type of correlated 'necklace' dislocation consisting of multiple short component dislocations in adjacent twins, connected like the links of a necklace. Such dislocations are formed in the highly oriented nanotwinned structure under cyclic loading and help to maintain the stability of twin boundaries and the reversible damage, provided that the nanotwins are tilted within about 15 degrees of the loading axis. This cyclic deformation mechanism is distinct from the conventional strain localizing mechanisms associated with irreversible microstructural damage in single-crystal, coarse-grained, ultrafine-grained and nanograined metals.

  17. Cyclic nucleotide specific phosphodiesterases of Leishmania major

    Directory of Open Access Journals (Sweden)

    Linder Markus

    2006-03-01

    Full Text Available Abstract Background Leishmania represent a complex of important human pathogens that belong to the systematic order of the kinetoplastida. They are transmitted between their human and mammalian hosts by different bloodsucking sandfly vectors. In their hosts, the Leishmania undergo several differentiation steps, and their coordination and optimization crucially depend on numerous interactions between the parasites and the physiological environment presented by the fly and human hosts. Little is still known about the signalling networks involved in these functions. In an attempt to better understand the role of cyclic nucleotide signalling in Leishmania differentiation and host-parasite interaction, we here present an initial study on the cyclic nucleotide-specific phosphodiesterases of Leishmania major. Results This paper presents the identification of three class I cyclic-nucleotide-specific phosphodiesterases (PDEs from L. major, PDEs whose catalytic domains exhibit considerable sequence conservation with, among other, all eleven human PDE families. In contrast to other protozoa such as Dictyostelium, or fungi such as Saccharomyces cerevisiae, Candida ssp or Neurospora, no genes for class II PDEs were found in the Leishmania genomes. LmjPDEA contains a class I catalytic domain at the C-terminus of the polypeptide, with no other discernible functional domains elsewhere. LmjPDEB1 and LmjPDEB2 are coded for by closely related, tandemly linked genes on chromosome 15. Both PDEs contain two GAF domains in their N-terminal region, and their almost identical catalytic domains are located at the C-terminus of the polypeptide. LmjPDEA, LmjPDEB1 and LmjPDEB2 were further characterized by functional complementation in a PDE-deficient S. cerevisiae strain. All three enzymes conferred complementation, demonstrating that all three can hydrolyze cAMP. Recombinant LmjPDEB1 and LmjPDEB2 were shown to be cAMP-specific, with Km values in the low micromolar range

  18. Bucket foundations under lateral cyclic loading

    DEFF Research Database (Denmark)

    Foglia, Aligi

    To enable a prosperous development of offshore wind energy, economically feasible technologies must be developed. The monopod bucket foundation is likely to become a cost-effective sub-structure for offshore wind turbines and has the potential to make offshore wind more cost-competitive in the en......To enable a prosperous development of offshore wind energy, economically feasible technologies must be developed. The monopod bucket foundation is likely to become a cost-effective sub-structure for offshore wind turbines and has the potential to make offshore wind more cost......-competitive in the energy market. This thesis addresses issues concerning monopod bucket foundations in the hope of providing tools and ideas that could be used to optimize the design of this sub-structure. The work is focussed on the behaviour of bucket foundations under lateral cyclic loading. Other related...... and propaedeutic topics, such as bucket foundations under transient lateral loading and under monotonic lateral loading, are also investigated. All the scientific work is fundamentally based on small-scale experimental tests of bucket foundations in dense water-saturated sand. The most important scientific...

  19. Interuniversal entanglement in a cyclic multiverse

    Science.gov (United States)

    Robles-Pérez, Salvador; Balcerzak, Adam; Dąbrowski, Mariusz P.; Krämer, Manuel

    2017-04-01

    We study scenarios of parallel cyclic multiverses which allow for a different evolution of the physical constants, while having the same geometry. These universes are classically disconnected, but quantum-mechanically entangled. Applying the thermodynamics of entanglement, we calculate the temperature and the entropy of entanglement. It emerges that the entropy of entanglement is large at big bang and big crunch singularities of the parallel universes as well as at the maxima of the expansion of these universes. The latter seems to confirm earlier studies that quantum effects are strong at turning points of the evolution of the universe performed in the context of the timeless nature of the Wheeler-DeWitt equation and decoherence. On the other hand, the entropy of entanglement at big rip singularities is going to zero despite its presumably quantum nature. This may be an effect of total dissociation of the universe structures into infinitely separated patches violating the null energy condition. However, the temperature of entanglement is large/infinite at every classically singular point and at maximum expansion and seems to be a better measure of quantumness.

  20. The mycotoxin definition reconsidered towards fungal cyclic depsipeptides.

    Science.gov (United States)

    Taevernier, Lien; Wynendaele, Evelien; De Vreese, Leen; Burvenich, Christian; De Spiegeleer, Bart

    2016-04-02

    Currently, next to the major classes, cyclic depsipeptides beauvericin and enniatins are also positioned as mycotoxins. However, as there are hundreds more fungal cyclic depsipeptides already identified, should these not be considered as mycotoxins as well? The current status of the mycotoxin definition revealed a lack of consistency, leading to confusion about what compounds should be called mycotoxins. Because this is of pivotal importance in risk assessment prioritization, a clear and quantitatively expressed mycotoxin definition is proposed, based on data of widely accepted mycotoxins. Finally, this definition is applied to a set of fungal cyclic depsipeptides, revealing that some of these should indeed be considered as mycotoxins.

  1. Cyclic Peptide?Selenium Nanoparticles as Drug Transporters

    OpenAIRE

    Nasrolahi Shirazi, Amir; Tiwari, Rakesh K.; Oh, Donghoon; Sullivan, Brian; Kumar, Anil; Beni, Yousef A.; Parang, Keykavous

    2014-01-01

    A cyclic peptide composed of five tryptophan, four arginine, and one cysteine [W5R4C] was synthesized. The peptide was evaluated for generating cyclic peptide-capped selenium nanoparticles (CP?SeNPs) in situ. A physical mixing of the cyclic peptide with SeO3 ?2 solution in water generated [W5R4C]?SeNPs via the combination of reducing and capping properties of amino acids in the peptide structure. Transmission electron microscopy (TEM) images showed that [W5R4C]?SeNPs were in the size range of...

  2. Influence of cyclic torsional preloading on cyclic fatigue resistance of nickel - titanium instruments.

    Science.gov (United States)

    Pedullà, E; Lo Savio, F; Boninelli, S; Plotino, G; Grande, N M; Rapisarda, E; La Rosa, G

    2015-11-01

    To evaluate the effect of different torsional preloads on cyclic fatigue resistance of endodontic rotary instruments constructed from conventional nickel-titanium (NiTi), M-Wire or CM-Wire. Eighty new size 25, 0.06 taper Mtwo instruments (Sweden & Martina), size 25, 0.06 taper HyFlex CM (Coltene/Whaledent, Inc) and X2 ProTaper Next (Dentsply Maillefer) were used. The Torque and distortion angles at failure of new instruments (n = 10) were measured, and 0% (n = 10), 25%, 50% and 75% (n = 20) of the mean ultimate torsional strength as preloading condition were applied according to ISO 3630-1 for each brand. The twenty files tested for every extent of preload were subjected to 20 or 40 torsional cycles (n = 10). After torsional preloading, the number of cycles to failure was evaluated in a simulated canal with 60° angle of curvature and 5 mm of radius of curvature. Data were analysed using two-way analysis of variance. The fracture surface of each fragment was examined with a scanning electron microscope (SEM). Data were analysed by two-way analyses of variance. Preload repetitions did not influence the cyclic fatigue of the three brands; however, the 25%, 50% and 75% torsional preloading significantly reduced the fatigue resistance of all instruments tested (P HyFlex CM preloaded with 25% of the maximum torsional strength (P > 0.05). Torsional preloads reduced the cyclic fatigue resistance of conventional and treated (M-wire and CM-wire) NiTi rotary instruments except for size 25, 0.06 taper HyFlex CM instruments with a 25% of torsional preloading. © 2014 International Endodontic Journal. Published by John Wiley & Sons Ltd.

  3. Inositol cyclic triphosphate [inositol 1,2-(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets.

    OpenAIRE

    Ishii, H; Connolly, T M; Bross, T E; Majerus, P W

    1986-01-01

    Cleavage of polyphosphoinositides in vitro by phospholipase C results in formation of both cyclic and noncyclic inositol phosphates. We have now isolated the cyclic product of phosphatidylinositol 4,5-bisphosphate cleavage, inositol 1,2(cyclic)-4,5-triphosphate [cIns(1:2,4,5)P3], from thrombin-treated platelets. We found 0.2-0.4 nmol of cIns-(1:2,4,5)P3 per 10(9) platelets at 10 sec after thrombin; none was found in unstimulated platelets or in platelets 10 min after thrombin addition. We con...

  4. Cyclic Benzimidazole Derivatives and Their Antitumor Activity

    Directory of Open Access Journals (Sweden)

    Karminski-Zamola, G.

    2008-06-01

    Full Text Available Over the past years benzimidazole derivatives are one of the most extensively studied classes of heterocyclic compounds, and have received much attention from synthetic organic as well as medicinal chemists, because of their well known biological activities and their applications in several areas as materials in electronics, in electrochemistry as anticorrosive agents, as polymers or optical materials and fluorescent tags in DNA sequencing. The structure of vitamin B12, as an example, contains a benzimidazole group. Compounds containing benzimidazole nuclei show anticancer, antineoplastic, antiinfective, antibacterial, antifungal and many others activities. Due to the structural similarity of benzimidazole nuclei with some naturally occurring compounds such as purine, they can easily interact with biomolecules of the living systems. The introduction of an additional substituent on the benzimidazole nuclei has been increasing attention in the expectation that such changes could potentially affect the interaction of the molecules with biological targets. Fused cyclic benzimidazole derivatives, as benzimidazo[1,2-a]quinolines,benzimidazo[1,2-c]quinazolines, benzimidazo[2,1-b]isoquinolines and many others, have also interesting biological activities and most of them are very good anticancer agents.DNA is the molecular target of many anticancer drugs in clinical use and development. Compounds which can bind to DNA with intercalative or non-intercalative mechanism play a major role in biological processes such as gene transcription or DNA replication. Benzoannulated benzimidazole analogues contain a planar chromophore and have the ability to become inserted between adjacent base pairs of DNA double helix. Intercalators are recognized as one of the most important classes of anticancer agents. So an understanding of the drug-DNA interactions is a promising approach to developing novel reagents and plays a key role in pharmacology today.

  5. Pregnancy complicated by cyclic vomiting syndrome successfully treated with amitriptyline.

    Science.gov (United States)

    Tamai, Hanako; Kinugasa, Masato

    2015-06-01

    Some reports suggest that pregnancy leads to exacerbation of cyclic vomiting syndrome. We report a case of pregnancy complicated by cyclic vomiting syndrome that was successfully resolved with amitriptyline, with the subsequent birth of a healthy term neonate. A 27-year-old pregnant woman with cyclic vomiting syndrome was referred to our hospital at 12 weeks of gestation. After excluding other diagnoses, we administered amitriptyline, which had been discontinued temporarily at the time of pregnancy diagnosis. Once a therapeutic dose was achieved, her vomiting attacks ceased and the remainder of her prenatal course was uneventful. At 40 weeks of gestation, she delivered a female neonate. Prevention of vomiting attacks using appropriate agents is essential for the management of pregnancies complicated by cyclic vomiting syndrome.

  6. Alpha,gamma-cyclic peptide ensembles with a hydroxylated cavity.

    Science.gov (United States)

    Reiriz, César; Amorín, Manuel; García-Fandiño, Rebeca; Castedo, Luis; Granja, Juan R

    2009-11-07

    Here we describe a self-assembling alpha,gamma-cyclic tetrapeptide that contains the 4-amino-3-hydroxytetrahydrofuran-2-carboxylic acid, in which the hydroxy group is pointing towards the inner cavity of the resulting dimers.

  7. Association of Marijuana Use and Cyclic Vomiting Syndrome

    Directory of Open Access Journals (Sweden)

    Mithun B. Pattathan

    2012-06-01

    Full Text Available Cannabis use has become one of the most commonly abused drugs in the world. It is estimated that each year 2.6 million individuals in the USA become new users and most are younger than 19 years of age. Reports describe marijuana use as high as 40–50% in male Cyclic Vomiting Syndrome patients. It is this interest in cannabis in the World, coupled with recognition of a cyclic vomiting illness associated with its chronic use that beckons a review of the most current articles, as well as a contribution from our own experiences in this area. The similarities we have demonstrated for both cannibinoid hyperemesis syndrome and cyclic vomiting make the case that cannibinoid hyperemesis syndrome is a subset of patients who have the diagnoses of cyclic vomiting syndrome and the role of marijuana should always be considered in the diagnosis of CVS, particularly in males.

  8. Cyclic AMP Signaling: A Molecular Determinant of Peripheral Nerve Regeneration

    Science.gov (United States)

    Knott, Eric P.; Assi, Mazen; Pearse, Damien D.

    2014-01-01

    Disruption of axonal integrity during injury to the peripheral nerve system (PNS) sets into motion a cascade of responses that includes inflammation, Schwann cell mobilization, and the degeneration of the nerve fibers distal to the injury site. Yet, the injured PNS differentiates itself from the injured central nervous system (CNS) in its remarkable capacity for self-recovery, which, depending upon the length and type of nerve injury, involves a series of molecular events in both the injured neuron and associated Schwann cells that leads to axon regeneration, remyelination repair, and functional restitution. Herein we discuss the essential function of the second messenger, cyclic adenosine monophosphate (cyclic AMP), in the PNS repair process, highlighting the important role the conditioning lesion paradigm has played in understanding the mechanism(s) by which cyclic AMP exerts its proregenerative action. Furthermore, we review the studies that have therapeutically targeted cyclic AMP to enhance endogenous nerve repair. PMID:25177696

  9. Cyclic viscoelasticity and viscoplasticity of polypropylene/clay nanocomposites

    DEFF Research Database (Denmark)

    Drozdov, Aleksey; Christiansen, Jesper de Claville; Hog Lejre, Anne-Lise

    2012-01-01

    Observations are reported in tensile relaxation tests under stretching and retraction on poly-propylene/clay nanocomposites with various contents of filler. A two-phase constitutive model is developed in cyclic viscoelasticity and viscoplasticity of hybrid nanocomposites. Adjustable parameters...

  10. A Novel Cyclic Catalytic Reformer for Hydrocarbon Fuels Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposed Small Business Innovative Research (SBIR) Phase I addresses development of a compact reformer system based on a cyclic partial oxidation (POx)...

  11. Cyclical mastalgia: Prevalence and associated determinants in Hamadan City, Iran

    Directory of Open Access Journals (Sweden)

    Fatemeh Shobeiri

    2016-03-01

    Conclusions: Most of women with breast discomfort suffered cyclical mastalgia which severity can be determined by advanced age, age of marriage, history of abortion and history of premenstrual syndrome, but inversely by oral contraceptive use and exercise activity.

  12. Minimal quadratic residue cyclic codes of length 2n

    National Research Council Canada - National Science Library

    Sudhir Batra; S K Arora

    2005-01-01

    ...: Formulae and/or non-USASCII text omitted; see image) has 2n primitive idempotents. The explicit expressions for these primitive idempotents are obtained and the minimal QR cyclic codes of length 2^sup n...

  13. Recovery of Compressively Sampled Sparse Signals using Cyclic Matching Pursuit

    DEFF Research Database (Denmark)

    Sturm, Bob L.; Christensen, Mads Græsbøll; Gribonval, Rémi

    We empirically show how applying a pure greedy algorithm cyclically can recover compressively sampled sparse signals as well as other more computationally complex approaches, such as orthogonal greedy algorithms, iterative thresholding, and $\\ell_1$-minimization.......We empirically show how applying a pure greedy algorithm cyclically can recover compressively sampled sparse signals as well as other more computationally complex approaches, such as orthogonal greedy algorithms, iterative thresholding, and $\\ell_1$-minimization....

  14. Deformation localization and cyclic strength in polycrystalline molybdenum

    Energy Technology Data Exchange (ETDEWEB)

    Sidorov, O.T.; Rakshin, A.F.; Fenyuk, M.I.

    1983-06-01

    Conditions of deformation localization and its interrelation with cyclic strength in polycrystalline molybdenum were investigated. A fatigue failure of polycrystalline molybdenum after rolling and in an embrittled state reached by recrystallization annealing under cyclic bending at room temperature takes place under nonuniform distribution of microplastic strain resulting in a temperature rise in separate sections of more than 314 K. More intensive structural changes take place in molybdenum after rolling than in recrystallized state.

  15. Microgravity changes in heart structure and cyclic-AMP metabolism

    Science.gov (United States)

    Philpott, D. E.; Fine, A.; Kato, K.; Egnor, R.; Cheng, L.

    1985-01-01

    The effects of microgravity on cardiac ultrastructure and cyclic AMP metabolism in tissues of rats flown on Spacelab 3 are reported. Light and electron microscope studies of cell structure, measurements of low and high Km phosphodiesterase activity, cyclic AMP-dependent protein kinase activity, and regulatory subunit compartmentation show significant deviations in flight animals when compared to ground controls. The results indicate that some changes have occurred in cellular responses associated with catecholamine receptor interactions and intracellular signal processing.

  16. Facile and Green Synthesis of Saturated Cyclic Amines.

    Science.gov (United States)

    Hameed, Arruje; Javed, Sadia; Noreen, Razia; Huma, Tayyaba; Iqbal, Sarosh; Umbreen, Huma; Gulzar, Tahsin; Farooq, Tahir

    2017-10-12

    Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and azocanes. This review highlights some facile and green synthetic routes for the synthesis of unsubstituted, multisubstituted and highly functionalized saturated cyclic amines including one-pot, microwave assisted, metal-free, solvent-free and in aqueous media.

  17. Facile and Green Synthesis of Saturated Cyclic Amines

    Directory of Open Access Journals (Sweden)

    Arruje Hameed

    2017-10-01

    Full Text Available Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and azocanes. This review highlights some facile and green synthetic routes for the synthesis of unsubstituted, multisubstituted and highly functionalized saturated cyclic amines including one-pot, microwave assisted, metal-free, solvent-free and in aqueous media.

  18. Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach

    OpenAIRE

    Jose Maria Pereira de Godoy; Henrique Jose Pereira de Godoy; Aline Aparecida de Sene Souza; Ricardo Budtinger Filho; Maria de Fatima Guerreiro Godoy

    2017-01-01

    Idiopathic cyclic edema is a type of generalized edema that mainly affects women. Diagnosis is made by the patient's clinical history and an evaluation of the accumulation of weight during the day. The objective of this study is to report the clinical control of lymphedema associated with idiopathic cyclic edema using calcium dobesilate. A 55-year-old female patient reported generalized edema for years in that she woke up in the morning with her legs swollen and the edema worsened during the ...

  19. Response of monopiles under cyclic lateral loading in sand

    DEFF Research Database (Denmark)

    Nicolai, Giulio; Ibsen, Lars Bo

    2015-01-01

    Currently the main design guidelines propose to reduce the lateral resistance of offshore piles when accounting for cyclic loading. The present work provides results from laboratory tests in which such reduction has not occurred. The experimental investigation is based on testing a small-scale mo...... of the monopile. It is shown that the soil-pile system becomes stiffer and more resistant after applying cyclic loading, depending on the number of cycles....

  20. Paediatric cyclical Cushing's disease due to corticotroph cell hyperplasia.

    LENUS (Irish Health Repository)

    Noctor, E

    2015-06-01

    Cushing\\'s disease is very rare in the paediatric population. Although uncommon, corticotroph hyperplasia causing Cushing\\'s syndrome has been described in the adult population, but appears to be extremely rare in children. Likewise, cyclical cortisol hypersecretion, while accounting for 15 % of adult cases of Cushing\\'s disease, has only rarely been described in the paediatric population. Here, we describe a very rare case of a 13-year old boy with cyclical cortisol hypersecretion secondary to corticotroph cell hyperplasia.

  1. Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

    Directory of Open Access Journals (Sweden)

    Gijs Koopmanschap

    2014-03-01

    Full Text Available In the recent past, the design and synthesis of peptide mimics (peptidomimetics has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certain receptor. Moreover, these cyclic mimics force the molecule into a well-defined secondary structure. Constraint structural and conformational features are often found in biological active peptides. For the synthesis of cyclic constrained peptidomimetics usually a sequence of multiple reactions has been applied, which makes it difficult to easily introduce structural diversity necessary for fine tuning the biological activity. A promising approach to tackle this problem is the use of multicomponent reactions (MCRs, because they can introduce both structural diversity and molecular complexity in only one step. Among the MCRs, the isocyanide-based multicomponent reactions (IMCRs are most relevant for the synthesis of peptidomimetics because they provide peptide-like products. However, these IMCRs usually give linear products and in order to obtain cyclic constrained peptidomimetics, the acyclic products have to be cyclized via additional cyclization strategies. This is possible via incorporation of bifunctional substrates into the initial IMCR. Examples of such bifunctional groups are N-protected amino acids, convertible isocyanides or MCR-components that bear an additional alkene, alkyne or azide moiety and can be cyclized via either a deprotection–cyclization strategy, a ring-closing metathesis, a 1,3-dipolar cycloaddition or even via a sequence of multiple multicomponent reactions. The sequential IMCR-cyclization reactions can afford small cyclic peptide mimics (ranging from four- to seven-membered rings, medium-sized cyclic constructs or peptidic

  2. Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.

    Science.gov (United States)

    Koopmanschap, Gijs; Ruijter, Eelco; Orru, Romano Va

    2014-01-01

    In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certain receptor. Moreover, these cyclic mimics force the molecule into a well-defined secondary structure. Constraint structural and conformational features are often found in biological active peptides. For the synthesis of cyclic constrained peptidomimetics usually a sequence of multiple reactions has been applied, which makes it difficult to easily introduce structural diversity necessary for fine tuning the biological activity. A promising approach to tackle this problem is the use of multicomponent reactions (MCRs), because they can introduce both structural diversity and molecular complexity in only one step. Among the MCRs, the isocyanide-based multicomponent reactions (IMCRs) are most relevant for the synthesis of peptidomimetics because they provide peptide-like products. However, these IMCRs usually give linear products and in order to obtain cyclic constrained peptidomimetics, the acyclic products have to be cyclized via additional cyclization strategies. This is possible via incorporation of bifunctional substrates into the initial IMCR. Examples of such bifunctional groups are N-protected amino acids, convertible isocyanides or MCR-components that bear an additional alkene, alkyne or azide moiety and can be cyclized via either a deprotection-cyclization strategy, a ring-closing metathesis, a 1,3-dipolar cycloaddition or even via a sequence of multiple multicomponent reactions. The sequential IMCR-cyclization reactions can afford small cyclic peptide mimics (ranging from four- to seven-membered rings), medium-sized cyclic constructs or peptidic macrocycles (>12

  3. Effect of Surgical Removal of Endometriomas on Cyclic and Non-cyclic Pelvic Pain

    Directory of Open Access Journals (Sweden)

    Murat Api

    2015-07-01

    Full Text Available Background: Endometriosis is a complex disease with a spectrum of pain symptoms from mild dysmenorrhea to debilitating pelvic pain. There is no concrete evidence in the literature whether endometriotic cyst per se, causes pain spectrum related to the disease. The aim of the present study was to evaluate the effect of surgical removal of endometriomas on pain symptoms. Materials and Methods: In this prospective, observational, before-after study, which was conducted between March 2012 and January 2013 in Training and Research Hospital,Adana, Turkey, a total of 23 patients including 16 sexually active and 7 virgin symptomatic women were questioned for non-cyclic pelvic pain (NCPP, intensity of the NCPP, presence of cyclic dysmenorrhea, and dyspareunia before and after the endometrioma operation. Participants who were sonographically diagnosed and later pathologically confirmed as having endometrioma without sign and symptoms of deep infiltrative endometriosis (DIE were also questioned for pain symptoms before and after the laparoscopic removal of cyst wall. Patients with intraabdominal adhesions, history of pelvic inflammatory disease, and pathological diagnosis other than endometrioma were excluded. No ancillary procedures were applied for pain management, but if pain was present, pelvic peritoneal endometriotic lesions were ablated beside the removal of ovarian endometriotic cysts. Results: Out of 23 cases with endometrioma, 91 and 78% reported to have NCPP and dysmenorrhea, respectively, before the operation, while 60 and 48%, respectively, after the operation (McNemar’s test, P=0.016 for both figures. Among the sexually active cases, 31% (5/16 had dyspareunia before the operation and only 1 case reported the pain relief after the operation (McNemar’s test, P=1. Intensity of NCPP were reported to be none (8.7%, moderate (21.7%, severe (56.5% and unbearable (13% before the operation and decreased to none (43.5%, mild (43.5%, moderate (4

  4. 7 CFR 1412.33 - Payment yield for counter-cyclical payments for covered commodities.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Payment yield for counter-cyclical payments for... CROP YEARS Establishment of Yields for Direct and Counter-Cyclical Payments § 1412.33 Payment yield for counter-cyclical payments for covered commodities. The counter-cyclical payment yield for covered...

  5. Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose.

    Science.gov (United States)

    Hammerschmidt, Andreas; Chatterji, Bijon; Zeiser, Johannes; Schröder, Anke; Genieser, Hans-Gottfried; Pich, Andreas; Kaever, Volkhard; Schwede, Frank; Wolter, Sabine; Seifert, Roland

    2012-01-01

    The bacterial adenylyl cyclase toxins CyaA from Bordetella pertussis and edema factor from Bacillus anthracis as well as soluble guanylyl cyclase α(1)β(1) synthesize the cyclic pyrimidine nucleotide cCMP. These data raise the question to which effector proteins cCMP binds. Recently, we reported that cCMP activates the regulatory subunits RIα and RIIα of cAMP-dependent protein kinase. In this study, we used two cCMP agarose matrices as novel tools in combination with immunoblotting and mass spectrometry to identify cCMP-binding proteins. In agreement with our functional data, RIα and RIIα were identified as cCMP-binding proteins. These data corroborate the notion that cAMP-dependent protein kinase may serve as a cCMP target.

  6. Effect of Cyclic Loading on Modulus of Elasticity of Aspen Wood

    OpenAIRE

    Milan Gaff; Miroslav Gašparík

    2014-01-01

    This article investigates the modulus of elasticity of solid and laminated aspen wood of various thicknesses after cyclic loading. A three-point static bending test was carried out to determine the modulus of elasticity. Cyclically loaded samples were compared with samples without cyclic loading. For the laminated wood, the results demonstrated a statistically significant impact of cyclic loading on the elasticity modulus. In contrast, no significant impact of cyclic loading was shown for the...

  7. Cohomological field theories and global spectral curves

    NARCIS (Netherlands)

    Popolitov, A.

    2017-01-01

    In my thesis I consider interplay between several different structures in mathematical physics. These structures are used to solve a large class of problems in enumerative algebraic geometry and combinatorics in a universal way. The problems can range from counting certain one-dimensional drawings

  8. Seidel-Smith cohomology for tangles

    DEFF Research Database (Denmark)

    Rezazadegan, Reza

    2009-01-01

    We generalize the “symplectic Khovanov cohomology” of Seidel and Smith (Duke Math J 134(3):453–514, 2006) to tangles using the notion of symplectic valued topological field theory introduced by Wehrheim and Woodward (arXiv:0905.1368).......We generalize the “symplectic Khovanov cohomology” of Seidel and Smith (Duke Math J 134(3):453–514, 2006) to tangles using the notion of symplectic valued topological field theory introduced by Wehrheim and Woodward (arXiv:0905.1368)....

  9. On the torus cobordant cohomology spheres

    Indian Academy of Sciences (India)

    Abstract. Let G be a compact Lie group. In 1960, P A Smith asked the following question: “Is it true that for any smooth action of G on a homotopy sphere with exactly two fixed points, the tangent G-modules at these two points are isomorphic?” A result due to Atiyah and Bott proves that the answer is 'yes' for Zp and it is also ...

  10. On the torus cobordant cohomology spheres

    Indian Academy of Sciences (India)

    Is it true that for any smooth action of on a homotopy sphere with exactly two fixed points, the tangent -modules at these two points are isomorphic?" A result due to Atiyah and Bott proves that the answer is `yes' for Z Z p and it is also known ...

  11. Gromov–Witten invariants and quantum cohomology

    Indian Academy of Sciences (India)

    This article is an elaboration of a talk given at an international conference on Operator Theory, Quantum Probability, and Noncommutative Geometry held during December 20--23, 2004, at the Indian Statistical Institute, Kolkata. The lecture was meant for a general audience, and also prospective research students, the idea ...

  12. Cyclic Stretch Alters Vascular Reactivity of Mouse Aortic Segments

    Directory of Open Access Journals (Sweden)

    Arthur Leloup

    2017-10-01

    Full Text Available Large, elastic arteries buffer the pressure wave originating in the left ventricle and are constantly exposed to higher amplitudes of cyclic stretch (10% than muscular arteries (2%. As a crucial factor for endothelial and smooth muscle cell function, cyclic stretch has, however, never been studied in ex vivo aortic segments of mice. To investigate the effects of cyclic stretch on vaso-reactivity of mouse aortic segments, we used the Rodent Oscillatory Tension Set-up to study Arterial Compliance (ROTSAC. The aortic segments were clamped at frequencies of 6–600 bpm between two variable preloads, thereby mimicking dilation as upon left ventricular systole and recoiling as during diastole. The preloads corresponding to different transmural pressures were chosen to correspond to a low, normal or high amplitude of cyclic stretch. At different time intervals, cyclic stretch was interrupted, the segments were afterloaded and isometric contractions by α1-adrenergic stimulation with 2 μM phenylephrine in the absence and presence of 300 μM L-NAME (eNOS inhibitor and/or 35 μM diltiazem (blocker of voltage-gated Ca2+ channels were measured. As compared with static or cyclic stretch at low amplitude (<10 mN or low frequency (0.1 Hz, cyclic stretch at physiological amplitude (>10 mN and frequency (1–10 Hz caused better ex vivo conservation of basal NO release with time after mounting. The relaxation of PE-precontracted segments by addition of ACh to stimulate NO release was unaffected by cyclic stretch. In the absence of basal NO release (hence, presence of L-NAME, physiological in comparison with aberrant cyclic stretch decreased the baseline tension, attenuated the phasic contraction by phenylephrine in the absence of extracellular Ca2+ and shifted the smaller tonic contraction more from a voltage-gated Ca2+ channel-mediated to a non-selective cation channel-mediated. Data highlight the need of sufficient mechanical activation of endothelial and

  13. Cyclic plastic hinges with degradation effects for frame structures

    DEFF Research Database (Denmark)

    Tidemann, Lasse; Krenk, Steen

    2017-01-01

    A model of cyclic plastic hinges in frame structures including degradation effects for stiffness and strength is developed. The model is formulated via potentials in terms of section forces. It consists of a yield surface, described in a generic format permitting representation of general convex ...... is implemented in a computer program and used for analysis of some simple structures, illustrating the characteristic features of the cyclic response and the accuracy of the proposed model.......A model of cyclic plastic hinges in frame structures including degradation effects for stiffness and strength is developed. The model is formulated via potentials in terms of section forces. It consists of a yield surface, described in a generic format permitting representation of general convex...... and stiffness parameters. The cyclic plastic hinges are introduced into a six-component equilibrium-based beam element, using additive element and hinge flexibilities. When converted to stiffness format the plastic hinges are incorporated into the element stiffness matrix. The cyclic plastic hinge model...

  14. [Cyclic nucleotide phosphodiesterases: role in the heart and therapeutic perspectives].

    Science.gov (United States)

    Bedioune, Ibrahim; Bobin, Pierre; Karam, Sarah; Lindner, Marta; Mika, Delphine; Lechêne, Patrick; Leroy, Jérôme; Fischmeister, Rodolphe; Vandecasteele, Grégoire

    2016-01-01

    Cyclic nucleotide phosphodiesterases (PDEs) degrade the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), thereby regulating multiple aspects of cardiac function. This highly diverse class of enzymes encoded by 21 genes encompasses 11 families that are not only responsible for the termination of cyclic nucleotide signalling, but are also involved in the generation of dynamic microdomains of cAMP and cGMP, controlling specific cell functions in response to various neurohormonal stimuli. In the myocardium, the PDE3 and PDE4 families predominate, degrading cAMP and thereby regulating cardiac excitation-contraction coupling. PDE3 inhibitors are positive inotropes and vasodilators in humans, but their use is limited to acute heart failure and intermittent claudication. PDE5 inhibitors, which are used with success to treat erectile dysfunction and pulmonary hypertension, do not seem efficient in heart failure with preserved ejection fraction. There is experimental evidence however that these PDE, as well as other PDE families including PDE1, PDE2 and PDE9, may play important roles in cardiac diseases, such as hypertrophy and heart failure (HF). After a brief presentation of the cyclic nucleotide pathways in cardiac myocytes and the major characteristics of the PDE superfamily, this review will focus on the potential use of PDE inhibitors in HF, and the recent research developments that could lead to a better exploitation of the therapeutic potential of these enzymes in the future. © Société de Biologie, 2016.

  15. Low severity coal liquefaction promoted by cyclic olefins

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, C.W.

    1992-01-01

    Low severity coal liquefaction promoted by cyclic olefins offers a means of liquefying coal at low severity conditions. Lower temperature, 350[degrees]C, and lower hydrogen pressure, 500 psi, have been used to perform liquefaction reactions. The presence of the cyclic olefin, hexahydroanthracene, made a substantial difference in the conversion of Illinois No. 6 coal at these low severity conditions. The Researchperformed this quarter was a parametric evaluation of the effect of different parameters on the coal conversion and product distribution from coal. The effect of the parameters on product distribution from hexahydroanthracene was also determined. The work planned for next quarter includes combining the most effective parametric conditions for the low severity reactions and determining their effect. The second part ofthe research performed this quarter involved performing Fourier transform infrared (FTIR) spectroscopy using cyclic olefins. The objective of this study was to determine the feasibility of using FTIR and a heated cell to determine the reaction pathway that occurs in the hydrogen donation reactions from cyclic olefins. The progress made to date includes evaluating the FTIR spectra of cyclic olefins and their expected reaction products. This work is included in this progress report.

  16. Cyclic AMP system in muscle tissue during prolonged hypokinesia

    Science.gov (United States)

    Antipenko, Y. A.; Bubeyev, Y. A.; Korovkin, B. F.; Mikhaleva, N. P.

    1980-01-01

    Components of the cyclic Adenosine-cyclic-35-monophosphate (AMP) system in the muscle tissue of white rats were studied during 70-75 days of hypokinesia, created by placing the animals in small booths which restricted their movements, and during the readaptation period. In the initial period, cyclic AMP levels and the activities of phosphodiesterase and adenylate cyclase in muscle tissue were increased. The values for these indices were roughly equal for controls and experimental animals during the adaptation period, but on the 70th day of the experiment cAMP levels dropped, phosphodiesterase activity increased, and the stimulative effect of epinephrine on the activity of adenylate cyclase decreased. The indices under study normalized during the readaptation period.

  17. Laboratory Test Setup for Cyclic Axially Loaded Piles in Sand

    DEFF Research Database (Denmark)

    Thomassen, Kristina; Ibsen, Lars Bo; Andersen, Lars Vabbersgaard

    2017-01-01

    This paper presents a comprehensive description and the considerations regarding the design of a new laboratory test setup for testing cyclic axially loaded piles in sand. The test setup aims at analysing the effect of axial one-way cyclic loading on pile capacity and accumulated displacements....... Another aim was to test a large diameter pile segment with dimensions resembling full-scale piles to model the interface properties between pile and sand correctly. The pile segment was an open-ended steel pipe pile with a diameter of 0.5 m and a length of 1 m. The sand conditions resembled the dense sand...... determined from the API RP 2GEO standard and from the test results indicated over consolidation of the sand. Two initial one-way cyclic loading tests provided results of effects on pile capacity and accumulated displacements in agreement with other researchers’ test results....

  18. Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach

    Science.gov (United States)

    Pereira de Godoy, Henrique Jose; de Sene Souza, Aline Aparecida; Budtinger Filho, Ricardo; de Fatima Guerreiro Godoy, Maria

    2017-01-01

    Idiopathic cyclic edema is a type of generalized edema that mainly affects women. Diagnosis is made by the patient's clinical history and an evaluation of the accumulation of weight during the day. The objective of this study is to report the clinical control of lymphedema associated with idiopathic cyclic edema using calcium dobesilate. A 55-year-old female patient reported generalized edema for years in that she woke up in the morning with her legs swollen and the edema worsened during the day. The physical examination revealed generalized edema. After four days of treatment with calcium dobesilate, the patient returned to the Clínica Godoy, Brazil, with less edema and reductions in body weight and the amount of extracellular and intracellular fluid. With further treatment, there was a total reduction of the edema. It is concluded that calcium dobesilate helps to control lymphedema secondary to idiopathic cyclic edema. PMID:28913000

  19. Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach

    Directory of Open Access Journals (Sweden)

    Jose Maria Pereira de Godoy

    2017-01-01

    Full Text Available Idiopathic cyclic edema is a type of generalized edema that mainly affects women. Diagnosis is made by the patient’s clinical history and an evaluation of the accumulation of weight during the day. The objective of this study is to report the clinical control of lymphedema associated with idiopathic cyclic edema using calcium dobesilate. A 55-year-old female patient reported generalized edema for years in that she woke up in the morning with her legs swollen and the edema worsened during the day. The physical examination revealed generalized edema. After four days of treatment with calcium dobesilate, the patient returned to the Clínica Godoy, Brazil, with less edema and reductions in body weight and the amount of extracellular and intracellular fluid. With further treatment, there was a total reduction of the edema. It is concluded that calcium dobesilate helps to control lymphedema secondary to idiopathic cyclic edema.

  20. Durability of Modified Expanded Polystyrene Concrete after Dynamic Cyclic Loading

    Directory of Open Access Journals (Sweden)

    Wenbo Shi

    2016-01-01

    Full Text Available EPS concrete was produced by mixing the expanded polystyrene spheres (EPS and polymer emulsion and thickener to the matrix concrete, and this concrete had good vibration energy absorption characteristics. Based on the experimental data obtained on EPS volume ratio of 0%, 20%, 30%, and 40% by replacing matrix or coarse aggregate, the two design styles had nearly the same compressive strength. By applying frequency of 5 Hz, 50000 or 100000 times, 40 KN, 50 KN, and 60 KN cyclic loading, it is shown that the higher the inclusion size was, the lower the compressive strength of the EPS concrete would be; the larger the applying dynamic cyclic load was, the more obvious the compressive strength changing would be. Meanwhile, the strength of EPS concrete had no evident change after durability test. The results of this research had practical significance on using EPS concrete in some long-term cyclic dynamic load engineering.

  1. Low Severity Coal Liquefaction Promoted by Cyclic Olefins

    Energy Technology Data Exchange (ETDEWEB)

    Christine W. Curtis

    1998-04-09

    The development of the donor solvent technology for coal liquefaction has drawn a good deal of attention over the last three decades. The search for better hydrogen donors led investigators to a class of compounds known as cyclic olefins. Cyclic olefins are analogues of the conventional hydroaromatic donor species but do not contain aromatic rings. The cyclic olefins are highly reactive compounds which readily release their hydrogen at temperatures of 200 C or higher. Considerable effort has been o expended toward understanding the process of hydrogen donation. Most of this work was conducted in bomb reactors, with product analysis being carried out after the reaction was complete. Efforts directed towards fundamental studies of these reactions in situ are rare. The current work employs a high temperature and high pressure infrared cell to monitor in situ the concentrations of reactants and products during hydrogen release from hydrogen donor compounds.

  2. Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach.

    Science.gov (United States)

    Pereira de Godoy, Jose Maria; Pereira de Godoy, Henrique Jose; de Sene Souza, Aline Aparecida; Budtinger Filho, Ricardo; de Fatima Guerreiro Godoy, Maria

    2017-01-01

    Idiopathic cyclic edema is a type of generalized edema that mainly affects women. Diagnosis is made by the patient's clinical history and an evaluation of the accumulation of weight during the day. The objective of this study is to report the clinical control of lymphedema associated with idiopathic cyclic edema using calcium dobesilate. A 55-year-old female patient reported generalized edema for years in that she woke up in the morning with her legs swollen and the edema worsened during the day. The physical examination revealed generalized edema. After four days of treatment with calcium dobesilate, the patient returned to the Clínica Godoy, Brazil, with less edema and reductions in body weight and the amount of extracellular and intracellular fluid. With further treatment, there was a total reduction of the edema. It is concluded that calcium dobesilate helps to control lymphedema secondary to idiopathic cyclic edema.

  3. Detection of Corrosion Resistance of Components in Cyclic Salt Spray

    Directory of Open Access Journals (Sweden)

    Štefan Álló

    2015-01-01

    Full Text Available The aim of this research is, to investigate the influence of two types of cyclic salt spray tests on parts surface treated with galvanizing. On the selected components was performed the method Zn-Ni surface treating on the bath line. Subsequently were the components embedded in the corrosion chamber, where was performed two types of cyclic salt test. In the first test was performed 4 hour salt spray, 8 hours drying, 60 hours condensation and 24 hours drying. Once cycle lasted 96 hours, and it was repeated 4 times. During the second test was performed 2 hours salt spray, 2 hours condensation. The cycle was repeated 4 times, that means 96 hours. After the cycle was performed 72 hours free relaxation in the corrosion chamber, on 20–25 °C temperature. As the research showed, after the cyclic salt spray was no red corrosion on the selected components. The white corrosion appeared only slightly.

  4. Cyclic operation of power plant; Cyklisk drift av kraftvaermeverk

    Energy Technology Data Exchange (ETDEWEB)

    Storesund, Jan

    2007-12-15

    The great majority of power plants are designed for base load operation with a relatively small number of starts and stops per year. Therefore, there has been no need to consider fatigue at design. Over the last few years operation with more frequent starts and stops exists as a consequence of swinging electricity prices that has become common. This involves significantly higher frequency of damages; not least fatigue relates damages, and the number of severe failures in components that never before have had damage problems may increase as well. In the present work the different types of component that may suffer from cyclic operation related damage are gathered by a literature survey and described as follows: - where and how the damages comes up, - constructions that should be avoided, - non-destructive testing (NDT) for damage that may come up under cyclic operation, - calculation and assessment of integrity of critical components - areas where continued research would be valuable. Recommendations have been put together to be used to prevent cyclic operation related damage and to detect it in time. The target group for this study is i) plant owners of plants where cyclic operation is or may be present, ii) researchers in the area, and, iii) inspectors and NDT-operators. There are quite a number of components where cyclic operation has been found to significantly influence the lift time. Some of these components are described in many papers whereas occasional papers have been found for others. The amount of information that is possible to get for a certain component is likely related to its significance for cyclic operation damage. The most frequently reported problem is ligament cracking of high temperature headers. Other components where extensive studies have been done are: wall panels, creep-fatigue loaded welds and turbine components

  5. Solving cyclical nurse scheduling problem using preemptive goal programming

    Science.gov (United States)

    Sundari, V. E.; Mardiyati, S.

    2017-07-01

    Nurse scheduling system in a hospital is being modeled as a preemptive goal programming problem that is solved by using LINGO software with the objective function to minimize deviation variable at each goal. The scheduling is done cyclically, so every nurse is treated fairly since they have the same work shift portion with the other nurses. By paying attention to the hospital's rules regarding nursing work shift cyclically, it can be obtained that numbers of nurse needed in every ward are 18 nurses and the numbers of scheduling periods are 18 periods where every period consists of 21 days.

  6. Cyclic Matching Pursuits with Multiscale Time-frequency Dictionaries

    DEFF Research Database (Denmark)

    Sturm, Bob L.; Christensen, Mads Græsbøll

    2010-01-01

    We generalize cyclic matching pursuit (CMP), propose an orthogonal variant, and examine their performance using multiscale time-frequency dictionaries in the sparse approximation of signals. Overall, we find that the cyclic approach of CMP produces signal models that have a much lower approximation...... error than existing greedy iterative descent methods such as matching pursuit (MP), and are competitive with models found using orthogonal MP (OMP), and orthogonal least squares (OLS). This implies that CMP is a strong alternative to the more computationally complex approaches of OMP and OLS...

  7. Lipolymphedema Associated with Idiopathic Cyclic Edema: A Therapeutic Approach

    OpenAIRE

    Pereira de Godoy, Jose Maria; Pereira de Godoy, Henrique Jose; de Sene Souza, Aline Aparecida; Budtinger Filho, Ricardo; de Fatima Guerreiro Godoy, Maria

    2017-01-01

    Idiopathic cyclic edema is a type of generalized edema that mainly affects women. Diagnosis is made by the patient’s clinical history and an evaluation of the accumulation of weight during the day. The objective of this study is to report the clinical control of lymphedema associated with idiopathic cyclic edema using calcium dobesilate. A 55-year-old female patient reported generalized edema for years in that she woke up in the morning with her legs swollen and the edema worsened during the ...

  8. Design of an instrumented model pile for axial cyclic loading

    OpenAIRE

    Rakotonindriana, Julio; Le Kouby, Alain; Buttigieg, Stéphane; Derkx, François; Thorel, Luc; Garnier, Jacques

    2010-01-01

    To study the behavior of a pile foundation under a cyclic axial loading, an instrumented pile was developed for centrifuge tests. The design of the instrumented pile takes into account some constraints due to centrifuge tests and allows us to install the pile in flight. The instrumentation of the pile permits the measure of the skin friction at five depths and the tip resistance. Some static and cyclic tests have been made and show the efficiency of the instrumented pile in capturing the main...

  9. Modeling the Damage Characteristics of Concrete Subjected to Cyclic Loadings

    Science.gov (United States)

    Ghatee, P.; Jaafar, M. S.; Ibrahim, A.; Talati, H.

    2017-11-01

    Various damage formulations have been used to simulate the inelastic behavior of granular composite materials, e.g., concrete, under cyclic loadings, but the results obtained differ from experimental data. The aim of this study is to develop general nonlinear damage formulations, with calibration capabilities, on the basis of two nonlinear indices, namely the tension and compression states, covering all cyclic loading conditions, including partial and complete unloading/reloading ones. Using verification procedures, the efficiency of calibration ability of the formulations, especially for computer programming, is illustrated.

  10. Laterally cyclic loading of monopile in dense sand

    DEFF Research Database (Denmark)

    Klinkvort, Rasmus Tofte; Hededal, Ole; Svensson, M.

    2011-01-01

    the loading conditions. In these tests the load conditions are controlled by two load characteristics, one controlling the level of the cyclic loading and one controlling the characteristic of the cyclic loading. The centrifuge tests were performed in dense dry sand on a pile with prototype dimensions...... used for wind turbine foundation. This is important in order to get the right failure mechanism in the sand. The load frame is controlled with a feedback system which enables force controlled load series. A total number of 8 tests have been carried. In all of the tests, the pile was loaded with 500...

  11. Laboratory Testing of Cyclic Laterally Loaded Pile in Cohesionless Soil

    DEFF Research Database (Denmark)

    Roesen, Hanne Ravn; Ibsen, Lars Bo; Hansen, Mette

    2013-01-01

    Offshore wind turbines are normally founded with large diameter monopiles and placed in rough environments subjected to variable lateral loads from wind and waves. A long-term lateral loading may create rotation (tilt) of the pile by change in the pile-soil system which is critical...... in the serviceability limit state. In this paper small-scale testing of a pile subjected to cyclic, lateral loading is treated in order to investigate the effect of cyclic loading. The test setup, which is an improvement of a previous setup, is described and the first results of testing are compared with previous...

  12. Physical Modelling of Cyclic Laterally Loaded Pile in Cohesionless Soil

    DEFF Research Database (Denmark)

    Hansen, Mette; Wolf, Torben K.; Rasmussen, Kristian L.

    Offshore wind turbines are normally founded with large diameter monopiles and placed in rough environments subjected to variable lateral loads from wind and waves. A long-term lateral loading may create rotation (tilt) of the pile by change in the pile-soil system which is critical...... in the serviceability limit state. In this paper small-scale testing of a pile subjected to cyclic, lateral loading is treated in order to investigate the effect of cyclic loading. The test setup, which is an improvement of a previous setup, is described and the first results of testing are compared with previous...

  13. Thermal cyclic durability testing of ceramic materials for turbine engines

    Science.gov (United States)

    Lindberg, L. J.

    1986-01-01

    The thermal cyclic durability of commercial ceramic materials for turbine engines was under evaluation since 1978. Ceramic materials are exposed to cyclic diesel-fired burner exhaust at either 1204 or 1371 C (2200 or 2500 F) for up to 3500 hours. The test conditions are selected to simulate the environment experienced by the hot flow path components in an automotive gas turbine engine. The silicon nitride and silicon carbide materials tested are the same ceramic materials currently used on the AGT100 and AGT101 ceramic turbine engine program.

  14. Selective hydrodeoxygenation of cyclic vicinal diols to cyclic alcohols over tungsten oxide-palladium catalysts.

    Science.gov (United States)

    Amada, Yasushi; Ota, Nobuhiko; Tamura, Masazumi; Nakagawa, Yoshinao; Tomishige, Keiichi

    2014-08-01

    Hydrodeoxygenation of cyclic vicinal diols such as 1,4-anhydroerythritol was conducted over catalysts containing both a noble metal and a group 5-7 transition-metal oxide. The combination of Pd and WOx allowed the removal of one of the two OH groups selectively. 3-Hydroxytetrahydrofuran was obtained from 1,4-anhydroerythritol in 72 and 74% yield over WOx -Pd/C and WOx -Pd/ZrO2 , respectively. The WOx -Pd/ZrO2 catalyst was reusable without significant loss of activity if the catalyst was calcined as a method of regeneration. Characterization of WOx -Pd/C with temperature-programmed reduction, X-ray diffraction, and transmission electron microscopy/energy-dispersive X-ray spectroscopy suggested that Pd metal particles approximately 9 nm in size were formed on amorphous tungsten oxide particles. A reaction mechanism was proposed on the basis of kinetics, reaction results with tungsten oxides under an atmosphere of Ar, and density functional theory calculations. A tetravalent tungsten center (W(IV) ) was formed by reduction of WO3 with the Pd catalyst and H2 , and this center served as the reductant for partial hydrodeoxygenation. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Apoptotic Cell Localization in Preantral and Antral Follicles in Relation to Non-cyclic and Cyclic Gilts.

    Science.gov (United States)

    Phoophitphong, D; Srisuwatanasagul, S; Koonjaenak, S; Tummaruk, P

    2016-06-01

    The objective of this study was to determine apoptotic cell localization in preantral and antral follicles of porcine ovaries. Additionally, the proportion of cells undergoing apoptosis was also compared between delayed puberty gilts and normal cyclic gilts. Ovarian tissues were obtained from 34 culled gilts with age and weight of 270.1 ± 3.9 days and 143.8 ± 2.4 kg, respectively. The gilts were classified according to their ovarian appearance as 'non-cyclic' (n = 7) and 'cyclic' (n = 27) gilts. The terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) assay was used to determine apoptotic cell expression in different compartments of the ovarian tissue sections. All apparent preantral (n = 110) and antral (n = 262) follicles were evaluated using image analysis software. It was found that apoptotic cells were expressed in both granulosa (22.2%) and theca cell layers (21.3%) of the follicles in the porcine ovaries. The proportion of apoptotic cells in the granulosa layer in the follicles was positively correlated with that in the theca layer (r = 0.90, p  0.05) or theca cell layers (28.6% and 26.5%, p > 0.05). The proportion of apoptotic cells in non-cyclic gilts was higher than cyclic gilts in both granulosa (31.7% and 22.6%, p gilts than cyclic gilts. This implied that apoptosis could be used as a biologic marker for follicular development/function and also that apoptosis was significantly associated with anoestrus or delayed puberty in gilts, commonly observed in tropical climates. © 2016 Blackwell Verlag GmbH.

  16. Nearly Cyclic Pursuit and its Hierarchical variant for Multi-agent Systems

    DEFF Research Database (Denmark)

    Iqbal, Muhammad; Leth, John-Josef; Ngo, Trung Dung

    2015-01-01

    The rendezvous problem for multiple agents under nearly cyclic pursuit and hierarchical nearly cyclic pursuit is discussed in this paper. The control law designed under nearly cyclic pursuit strategy enables the agents to converge at a point dictated by a beacon. A hierarchical version of the nea......The rendezvous problem for multiple agents under nearly cyclic pursuit and hierarchical nearly cyclic pursuit is discussed in this paper. The control law designed under nearly cyclic pursuit strategy enables the agents to converge at a point dictated by a beacon. A hierarchical version...

  17. Estimation of cyclic stress-strain curves for low-alloy steel from hardness

    Directory of Open Access Journals (Sweden)

    R. Basan

    2010-04-01

    Full Text Available This article describes investigations into the existence of correlation between experimentally determined cyclic parameters and hardness of quenched and tempered representative low-alloy steel 42CrMo4. A good correlation was found to exist between cyclic strength coefficient K’ and Brinell hardness HB, but not between cyclic strain hardening exponent n‘ and hardness HB. Nevertheless, good agreement between calculated and experimental cyclic stress-strain curves shows that cyclic parameters i.e. cyclic stress-strain curves of the investigated steel can be successfully estimated from its hardness.

  18. Some aspects of skin friction of piles in clay under cyclic loading

    Science.gov (United States)

    Poulos, H. G.

    1980-12-01

    A number of mode tests on a pile shaft in clay were performed to investigate the influence of cyclic loading on the ultimate skin friction. It is found that the loss of skin friction due to cyclic loading depends on both the cyclic displacement prior to failure and the number of cycles of load. Such loss of skin friction can occur both for one way or two way cyclic loading. The cyclic stiffness of the pile depends on the cyclic displacement of the pile. The rate of loading also influences the skin friction but does not appear to influence the stiffness of the pile.

  19. Fluorescence-Based Reporter for Gauging Cyclic Di-GMP Levels in Pseudomonas aeruginosa

    DEFF Research Database (Denmark)

    Rybtke, Morten T.; Borlee, Bradley R.; Murakami, Keiji

    2012-01-01

    of antipathogenic compounds. Here we describe the development of fluorescent monitors that can gauge the cellular level of cyclic di-GMP in P. aeruginosa. We have created cyclic di-GMP level reporters by transcriptionally fusing the cyclic di-GMP-responsive cdrA promoter to genes encoding green fluorescent protein....... We show that the reporter constructs give a fluorescent readout of the intracellular level of cyclic di-GMP in P. aeruginosa strains with different levels of cyclic di-GMP. Furthermore, we show that the reporters are able to detect increased turnover of cyclic di-GMP mediated by treatment of P...

  20. Cyclic and heteroclinic flows near general static spherically symmetric black holes: semi-cyclic flows - addendum and corrigendum

    Energy Technology Data Exchange (ETDEWEB)

    Azreg-Ainou, Mustapha [Baskent University, Engineering Faculty, Ankara (Turkey)

    2017-01-15

    We present new accretion solutions of a polytropic perfect fluid onto an f(R)-gravity de Sitter-like black hole. We consider two f(R)-gravity models and obtain finite-period cyclic flows oscillating between the event and cosmological horizons as well as semi-cyclic critical flows executing a two-way motion from and back to the same horizon. Besides the generalizations and new solutions presented in this work, a corrigendum to Eur. Phys. J. C (2016) 76:280 is provided. (orig.)

  1. Cyclic Deformation of Copper and Copper-Alumina Polycrystals

    DEFF Research Database (Denmark)

    Brøndsted, Povl; Bilde-Sørensen, Jørgen; Pedersen, Ole Bøcker

    1983-01-01

    . Electron microscopy shows that PSBs do not control the cyclic deformation of fine-grained Cu and Cu-Al//2O//3 at a tensile plastic strain amplitude of 10** minus **3. The dislocation microstructures in saturated Cu and Cu-Al//2O//3 are modified by the grain-boundaries, but they are only weakly affected...

  2. Effect of Color Shading Procedures and Cyclic Loading on the ...

    African Journals Online (AJOL)

    2018-02-07

    Feb 7, 2018 ... Purpose: Zirconia is the most preferred ceramic restoration in posterior areas because of its flexural strength. The aim of the study is the evaluation of biaxial flexural strength of different colored zirconium oxide core materials after cyclic loading. Material and Methods: Zirconia discs (12 mm diameter and 1.2 ...

  3. Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling

    KAUST Repository

    Gehring, Christoph A.

    2017-10-04

    The cyclic nucleotide monophosphates (cNMPs), and notably 3′,5′-cyclic guanosine monophosphate (cGMP) and 3′,5′-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and differentiation, photosynthesis, and biotic and abiotic defense. At the single molecule level, we are now beginning to understand how cNMPs modify specific target molecules such as cyclic nucleotide-gated channels, while at the systems level, a recent study of the Arabidopsis cNMP interactome has identified novel target molecules with specific cNMP-binding domains. A major advance came with the discovery and characterization of a steadily increasing number of guanylate cyclases (GCs) and adenylate cyclases (ACs). Several of the GCs are receptor kinases and include the brassinosteroid receptor, the phytosulfokine receptor, the Pep receptor, the plant natriuretic peptide receptor as well as a nitric oxide sensor. We foresee that in the near future many more molecular mechanisms and biological roles of GCs and ACs and their catalytic products will be discovered and further establish cNMPs as a key component of plant responses to the environment.

  4. Undrained behaviour of volcanic soils under monotonic and cyclic loading

    Science.gov (United States)

    de Cristofaro, Martina; Brunzo, Antonia; Mottola, Luciano; Netti, Nadia; Olivares, Lucio; Orense, Rolando; Asadi, Sadeq

    2017-04-01

    Undrained behaviour of volcanic soils under monotonic and cyclic loading. In this study, we focus on the undrained behaviour of volcanic deposits under monotonic and cyclic loading in order to define the susceptibility to liquefaction of granular volcanic deposits. We assume that, in the case of saturated granular volcanic deposits susceptible to liquefaction, an undrained unstable behaviour can be responsible for both, the evolution of flowslide due to rainfall and liquefaction under seismic loading. Starting from these considerations we define a complex experimental program to analyze their undrained behaviour through laboratory testing on reconstituted specimens of cohesionless volcanic soils. The first part of the experimental program is devoted to the use of the steady state concept to evaluate the influence of void ratio and effective confining pressure on the undrained behaviour of Cervinara pyroclastic soils (Italy) under monotonic and cyclic loading. The second part of the experimental program is devoted to the analysis of the influence of particles crushing of pumice soils from Rangiriri (New Zeland) in both monotonic and cyclic undrained triaxial tests.

  5. Mechanism of Cyclically Polarity Reversing Solar Magnetic Cycle as ...

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... We briefly describe historical development of the concept of solar dynamo mechanism that generates electric current and magnetic field by plasma flows inside the solar convection zone. The dynamo is the driver of the cyclically polarity reversing solar magnetic cycle. The reversal process can easily and ...

  6. Characterizing and modelling cyclic behaviour in non-stationary ...

    Indian Academy of Sciences (India)

    To get an insight into the occurrence of cyclic variations, we then proceed to model these wavelet coefficients using genetic programming (GP) approach and using the standard embedding technique in the reconstructed phase space. It is found that the standard methods (GP as well as artificial neural networks) fail to model ...

  7. Photoelectron spectra and structures of three cyclic dipeptides

    DEFF Research Database (Denmark)

    Wickrama Arachchilage, A.P.; Wang, F.; Feyer, V.

    2012-01-01

    We have investigated the electronic structure of three cyclic dipeptides: cyclo(Histidyl-Glycyl) (cHisGly), cyclo(Tyrosyl-Prolyl) (cTyrPro), and cyclo(Phenylalanyl-Phenylalanyl) (cPhePhe) in the vapor phase, by means of photoemission spectroscopy and theoretical modeling. The last compound was ev...

  8. Cyclic AMP response element binding protein and brain-derived ...

    Indian Academy of Sciences (India)

    Madhu

    The transcription factor cyclic AMP response element binding protein (CREB) and the neurotrophin brain-derived neurotrophic factor (BDNF) are targets of diverse classes of antidepressants and are known to be regulated in animal models and in patients suffering from depression. Given their role in neuronal plasticity, ...

  9. Spatial pattern switching enables cyclic evolution in spatial epidemics

    NARCIS (Netherlands)

    Boerlijst, M.C.; van Ballegooijen, W.M.

    2010-01-01

    Infectious diseases often spread as spatial epidemic outbreak waves. A number of model studies have shown that such spatial pattern formation can have important consequences for the evolution of pathogens. Here, we show that such spatial patterns can cause cyclic evolutionary dynamics in selection

  10. Towards Green Cyclic Carbonate Synthesis : Heterogeneous and Homogeneous Catalyst Development

    NARCIS (Netherlands)

    Stewart, J.A.

    2015-01-01

    This PhD research serves to implement both known and novel catalytic systems for the purpose of cyclic carbonate synthesis from biomass-derived substrates. Such products have been earmarked as potential monomers for non-isocyanate polyurethanes (NIPUs), amongst other uses. Particular attention has

  11. Cyclic Pure Greedy Algorithms for Recovering Compressively Sampled Sparse Signals

    DEFF Research Database (Denmark)

    Sturm, Bob L.; Christensen, Mads Græsbøll; Gribonval, Remi

    2011-01-01

    The pure greedy algorithms matching pursuit (MP) and complementary MP (CompMP) are extremely computationally simple, but can perform poorly in solving the linear inverse problems posed by the recovery of compressively sampled sparse signals. We show that by applying a cyclic minimization principle...

  12. Laboratory experiments of bucket foundations under cyclic loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo

    This report collects information on the experimental campaign concerning bucket foundations under lateral cyclic loading conducted by the authors between 2011 and 2014. The report includes a step by step manual on the test procedures and a number of information and graphs for each experiment...

  13. Cyclic plasticity of recrystallized Mo at low temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Chen, D.L.; Weiss, B.; Stickler, R. [Vienna Univ. (Austria)

    1997-08-30

    The cyclic stress-strain behavior of recrystallized Mo at temperatures below the `knee` temperature T{sub K} and various loading rates was investigated. It was possible to differentiate between a micro- and macro-plastic region depending on temperature, loading rate and stress amplitude. This difference was related to characteristic dislocation arrangements. (orig.) 12 refs.

  14. Cyclic movement frequency is associated with muscle typology in athletes.

    Science.gov (United States)

    Bex, T; Baguet, A; Achten, E; Aerts, P; De Clercq, D; Derave, W

    2017-02-01

    There is a continuing research interest in the muscle fiber type composition (MFTC) of athletes. Recently, muscle carnosine quantification by proton magnetic resonance spectroscopy ((1) H-MRS) was developed as a new non-invasive method to estimate MFTC. This cross-sectional study aims to better understand estimated MFTC in relation to (a) different disciplines within one sport; (b) cyclic sport exercise characteristics; (c) within-athlete variability; and (d) athlete level. A total of 111 elite athletes (74 runners, 7 triathletes, 11 swimmers, 14 cyclists and 5 kayakers) and 188 controls were recruited to measure muscle carnosine in gastrocnemius and deltoid muscle by (1) H-MRS. Within sport disciplines, athletes were divided into subgroups (sprint-, intermediate-, and endurance-type). The controls were used as reference population to allow expression of the athletes' data as Z-scores. Within different sports, endurance-type athletes systematically showed the lowest Z-score compared to sprint-type athletes, with intermediate-type athletes always situated in between. Across the different sports disciplines, carnosine content showed the strongest significant correlation with cyclic movement frequency (R = 0.86, P = 0.001). Both within and between different cyclic sports, estimated MFTC was divergent between sprint- and endurance-type athletes. Cyclic movement frequency, rather than exercise duration came out as the most determining factor for the optimal estimated MFTC in elite athletes. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Cyclical Haematuria sequel to uterine Myomectomy: A case report ...

    African Journals Online (AJOL)

    Keywords: Iatrogenic vesico-uterine fistula, Cyclical haematuria, Transabdominal fistulectomy. Résumé Une mariée sant enfant de trente ans avait en une myomectomie difficile faite pour un médicin generaliste un an avant sa presentation. Deux mois après l' operation elle avait en ses rigle mais avec une haematurie totale ...

  16. METHODOLOGICAL ASPECTS OF ECONOMIC EVENTS CYCLICITY METHOD CONSIDERATION

    Directory of Open Access Journals (Sweden)

    Yaskova Natalia Yur'ievna

    2017-07-01

    Full Text Available The cyclicity of economic phenomena is not only their immanent property but also the subject of economic analysis. The modern way of making managerial decisions requires analysis of a number of cycles that fill any kind of activity. Accounting and reconciliation of construction, design, investment, purchasing, reproduction, leasing and other cycles is important for the investment and construction sector, both from the point of view of the need for their synchronization and from the position of determining trends in sectoral development. The analysis has showed that three main types of development are characteristic for investment and construction activity. Increasing intensity is inherent in a high level of cyclic synchronization. The degradation trend arises as a result of mismatched cycles. The stabilization character is inherent in the regular modes of maintaining the established proportions and cyclical inter-conformity. The study of the cyclical nature of investment and building processes is impossible without understanding their co-ordination. The principles of synchronization and subordination of the cycles should be used not only for the construction of cost-effective systems but also for the development of management tools.

  17. Micromechanical studies of cyclic creep fracture under stress- controlled loading

    NARCIS (Netherlands)

    Giessen, E. van der; Tvergaard, V.

    1996-01-01

    This paper deals with a study of intergranular failure by creep cavitation under stress-controlled cyclic loading conditions. Loading is assumed to be slow enough that diffusion and creep mechanisms (including grain boundary sliding) dominate, leading to intergranular creep fracture. This study is

  18. Optical fibre Bragg grating recorded in TOPAS cyclic olefin copolymer

    DEFF Research Database (Denmark)

    Johnson, I.P.; Yuan, Scott Wu; Stefani, Alessio

    2011-01-01

    A report is presented on the inscription of a fibre Bragg grating into a microstructured polymer optical fibre fabricated from TOPAS cyclic olefin copolymer. This material offers two important advantages over poly (methyl methacrylate), which up to now has formed the basis for polymer fibre Bragg...

  19. Selective discrimination of cyclodextrin diols using cyclic sulfates

    DEFF Research Database (Denmark)

    Petrillo, Marta; Marinescu, Lavinia; Rousseau, Cyril

    2009-01-01

    A method for selective monofunctionalition of readily available cyclodextrin diols (2(A-F),3(A-F),6(B,C,E,F)-hexadeca-O-benzyl-alpha-cyclodextrin and 2(A-G),3(A-G),6(B,C,E-G)-nonadeca-O-benzyl-beta-cyclodextrin) by regioselective nucleophilic opening of their cyclic sulfates is presented. Although...

  20. Waiting times in discrete-time cyclic-service systems

    Science.gov (United States)

    Boxma, O. J.; Groenendijk, W. P.

    1987-03-01

    Single-server, multiqueue systems with cyclic service in discrete time are considered. Nonzero switchover times between consecutive queues are assumed; the service strategies at the various queues may differ. A decomposition for the amount of work in such systems is obtained, leading to an exact expression for a weighted sum of the mean waiting times at the various queues.

  1. Inorganic–Organic Hybrids Incorporating a Chiral Cyclic Ammonium ...

    African Journals Online (AJOL)

    Inorganic–Organic Hybrids Incorporating a Chiral Cyclic Ammonium Cation. ... South African Journal of Chemistry ... In this paper we report the synthesis and the crystal structure of eight inorganic–organic hybrids containing various lead halides as the inorganic motif and a chiral, primary ammonium cation as the organic ...

  2. Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani

    Science.gov (United States)

    Screening natural product extracts from National Cancer Institute Open Repository for antifungal discovery afforded hits for bioassay-guided fractionation. Upon LC-MS analysis of column fractions with antifungal activities to generate information on chemical structure, two new cyclic hexapeptides, m...

  3. Random matrix theory for pseudo-Hermitian systems: Cyclic blocks

    Indian Academy of Sciences (India)

    We discuss the relevance of random matrix theory for pseudo-Hermitian systems, and, for Hamiltonians that break parity and time-reversal invariance . In an attempt to understand the random Ising model, we present the treatment of cyclic asymmetric matrices with blocks and show that the nearest-neighbour spacing ...

  4. A numerical study of cyclic behaviour of polar ice sheets

    NARCIS (Netherlands)

    Oerlemans, J.

    1983-01-01

    Possible cyclic behaviour of polar ice sheets is studied with a numerical ice-flow model. The model includes a calculation of bedrock adjustment and temperature field in the ice sheet. Basal water is traced and affects ice-mass discharge. Relaxation oscillations occur only for low

  5. Passive cyclic pitch control for horizontal axis wind turbines

    Science.gov (United States)

    Bottrell, G. W.

    1981-01-01

    A flexible rotor concept, called the balanced pitch rotor, is described. The system provides passive adjustment of cyclic pitch in response to unbalanced pitching moments across the rotor disk. Various applications are described and performance predictions are made for wind shear and cross wind operating conditions. Comparisons with the teetered hub are made and significant cost savings are predicted.

  6. English Noun plurals: A Cyclic Account | van der Spuy ...

    African Journals Online (AJOL)

    English Noun plurals: A Cyclic Account. ... An account of the morphology of English noun plurals is given in order to illustrate the workings of the theory. ... that takes place after inflection; and second, a lexical theory requires a grammar with fewer components, and may be more economical than an inferential theory.

  7. Aeroelastic Vibrations and Stability in Cyclic Symmetric Domains

    Directory of Open Access Journals (Sweden)

    Bernard Lalanne

    2000-01-01

    wing. In this way, aerodynamic forces may be obtained as general as required, depending on successive time derivatives of degrees of freedom in addition to themselves. Finally, some special cases are given and stability is studied for a cyclic periodic blade assembly, even when mistuning between sectors can occur.

  8. TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides.

    Science.gov (United States)

    Lu, Xiaomeng; Brickson, Claire R; Murphy, Regina M

    2016-09-21

    β-Amyloid peptide (Aβ) self-associates into oligomers and fibrils, in a process that is believed to directly lead to neuronal death in Alzheimer's disease. Compounds that bind to Aβ, and inhibit fibrillogenesis and neurotoxicity, are of interest as an anti-Alzheimer therapeutic strategy. Peptides are particularly attractive for this purpose, because they have advantages over small molecules in their ability to disrupt protein-protein interactions, yet they are amenable to tuning of their properties through chemical means, unlike antibodies. Self-complementation and peptide library screening are two strategies that have been employed in the search for peptides that bind to Aβ. We have taken a different approach, by designing Aβ-binding peptides using transthyretin (TTR) as a template. Previously, we demonstrated that a cyclic peptide, with sequence derived from the known Aβ-binding site on TTR, suppressed Aβ aggregation into fibrils and protected neurons against Aβ toxicity. Here, we searched for cyclic peptides with improved efficacy, by employing the algorithm TANGO, designed originally to identify amyloidogenic sequences in proteins. By using TANGO as a guide to predict the effect of sequence modifications on conformation and aggregation, we synthesized a significantly improved cyclic peptide. We demonstrate that the peptide, in binding to Aβ, redirects Aβ toward protease-sensitive, nonfibrillar aggregates. Cyclic peptides designed using this strategy have attractive solubility, specificity, and stability characteristics.

  9. A new cyclic dipeptide from cultures of Coprinus plicatilis.

    Science.gov (United States)

    Zhao, Jiang-Yuan; Ding, Jian-Hai; Li, Zheng-Hui; Feng, Tao; Zhang, Hong-Bin; Liu, Ji-Kai

    2017-09-01

    Three cyclic dipeptides (1-3), including one new compound (1) were isolated from cultures of the basidiomycetes Coprinus plicatilis. Their structures were elucidated by spectroscopic methods, including extensive 2D NMR techniques. At the same time, all compounds were tested for their cytotoxicities against five human cancer cell lines.

  10. Behavior of a gravel-sand material on cyclic way

    Directory of Open Access Journals (Sweden)

    hocine bendadouche

    2014-12-01

    Full Text Available This article has the results of the cyclic triaxial compression tests to study the potential of liquefaction of a gravel-sand material.  The last part is devoted to the not drained cyclic tests and their analyses.  Many articles are devoted to the tests on the standard sand of laboratory Hostun in particular for the study of liquefaction or on reconstituted clays but few tests are carried out on a natural material.  The scarcity of cyclic tests on such rough natural materials shows the difficulty of assessing the seismic risk. Faced with these difficulties, the use of tests such as the CPT provides a different but very practical approach. The overall results show a trend of relatively high liquefaction of the material, even under conditions of moderate stress (qc / 2s'3 = 0.2. This trend is growing very strongly when the rate of cyclic loading reached 0.3. The CPT test also shows a great tendency to liquefaction with a safety factor of well below 1.

  11. Biosynthesis and regulation of cyclic lipopeptides in Pseudomonas fluorescens

    NARCIS (Netherlands)

    Bruijn, de I.

    2009-01-01

    Cyclic lipopeptides (CLPs) are surfactant and antibiotic metabolites produced by a variety of bacterial genera. For the genus Pseudomonas, many structurally different CLPs have been identified. CLPs play an important role in surface motility of Pseudomonas strains, but also in virulence and

  12. Quantitative effect and regulatory function of cyclic adenosine 5 ...

    Indian Academy of Sciences (India)

    Cyclic adenosine 5′-phosphate (cAMP) is a global regulator of gene expression in Escherichia coli. Despite decades of intensive study, the quantitative effect and regulatory function of cAMP remain the subjects of considerable debate. Here, we analyse the data in the literature to show that: In carbon-limited cultures ...

  13. Cyclic deformation behaviour of austenitic steels at ambient and ...

    Indian Academy of Sciences (India)

    The aim of the present investigation is to characterise cyclic deformation behaviour and plasticity-induced martensite formation of metastable austenitic stainless steels at ambient and elevated temperatures, taking into account the influence of the alloying elements titanium and niobium. Titanium and niobium are ...

  14. Route and fleet design for cyclic inventory routing

    NARCIS (Netherlands)

    Raa, Birger; Dullaert, Wout

    2017-01-01

    This paper presents a novel solution approach for planning cyclic distribution from a single depot to multiple customers with constant, deterministic demand rates. The objective is to minimize the total cost rate consisting of fleet costs, distribution costs from the depot to the customers and

  15. Cyclic irradiation method for production of radioisotope tracers using ...

    African Journals Online (AJOL)

    Cyclic Irradiation Method (CIM) involving repeated irradiation of samples at regular time intervals to build up activity has been adopted for the production of 82 Br, 72 Ga, 140La, 24 Na and 46 Sc isotopes using the low power Ghana Research Reactor-1. The results indicate that the specific activities of radioisotopes from ...

  16. Expression and diagnostic utility of anti-cyclic citrullinated peptide ...

    African Journals Online (AJOL)

    Background: Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous group of arthritis occurring in children. Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been recently included in the revised diagnostic criteria for adult onset rheumatoid arthritis. Its diagnostic value in JIA is still debatable. Objective: The ...

  17. Cyclic loading of sacroiliac screws in Tile C pelvic fractures.

    NARCIS (Netherlands)

    Zwienen, C.M. van; Bosch, E.W. van den; Hoek van Dijke, G.A.; Snijders, C.J.; Vugt, A.B. van

    2005-01-01

    BACKGROUND: To investigate the stiffness and strength of completely unstable pelvic fractures fixated both anteriorly and posteriorly under cyclic loading conditions, the authors conducted a randomized, comparative, cadaveric study. METHODS: In 12 specimens, a Tile C1 pelvic fracture was created.

  18. A theoretical model for predicting neutron fluxes for cyclic Neutron ...

    African Journals Online (AJOL)

    A theoretical model has been developed for prediction of thermal neutron fluxes required for cyclic irradiations of a sample to obtain the same activity previously used for the detection of any radionuclide of interest. The model is suitable for radiotracer production or for long-lived neutron activation products where the ...

  19. PLASMODIUM BERGHEI: CYCLICAL TRANSMISSIONS BY EXPERIMENTALLY INFECTED ANOPHELES QUADRIMACULATUS.

    Science.gov (United States)

    YOELI, M; MOST, H; BONE, G

    1964-06-26

    A number of strains of Plasmodium berghei were isolated from sporozoites of Anopheles dureni. Laboratory-bred Anopheles quadrimaculatus fed on carriers of the newly isolated strains showed overwhelming midgut infections and moderate or mild salivary gland infections. Successive cyclic transmissions by the bite of experimentally infected A. quadrimaculatus in laboratorybred tree rats (Thamnomys surdaster) were carried out.

  20. Effect of Color Shading Procedures and Cyclic Loading on the ...

    African Journals Online (AJOL)

    Purpose: Zirconia is the most preferred ceramic restoration in posterior areas because of its flexural strength. The aim of the study is the evaluation of biaxial flexural strength of different colored zirconium oxide core materials after cyclic loading. Material and Methods: Zirconia discs (12 mm diameter and 1.2 mm thickness) ...

  1. Effect of Color Shading Procedures and Cyclic Loading on the ...

    African Journals Online (AJOL)

    2018-02-07

    5 days ago ... Effect of Color Shading Procedures and Cyclic Loading on the Biaxial. Flexural Strength of Zirconia. I Tuncel, I Turp, A Usumez masking liner material, which is applied before layering the veneer ceramic.[2] Current studies has reported that coloring procedures affect the structure of the zirconia framework.

  2. Structure and stability of spiro-cyclic water clusters

    Indian Academy of Sciences (India)

    The structure and stability of spiro-cyclic water clusters containing up to 32 water molecules have been investigated at different levels of theory. ... Chemical Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Adyar, Chennai 600 020; Indian Institute of Science Education and ...

  3. A matrix ring description for cyclic convolutional codes

    NARCIS (Netherlands)

    Gluesing-Luerssen, Heide.; Tsang, Fai. -Lung.

    In this paper, we study convolutional codes with a specific cyclic structure. By definition, these codes are left ideals in a certain skew polynomial ring. Using that the skew polynomial ring is isomorphic to a matrix ring we can describe the algebraic parameters of the codes in a more accessible

  4. Resistance to cyclic loading of teeth restored with posts

    DEFF Research Database (Denmark)

    Sahafi, A; Peutzfeldt, A; Ravnholt, G

    2005-01-01

    This in vitro study evaluated the effect of presence of post, presence of core, and of shape, type, and surface treatment of posts on resistance to cyclic loading of crowned human teeth. For all teeth, crowns designed without ferrule were cast in sterling silver and luted with resin cement (Panavia...

  5. Ratchetting of porcine skin under uniaxial cyclic loading.

    Science.gov (United States)

    Kang, Guozheng; Wu, Xinfeng

    2011-04-01

    Skin soft tissue (e.g., porcine skin) was tested in vitro under uniaxial cyclic loading, and its biomechanical responses were investigated to realize some basic properties which are very significant in assessing the fatigue life of skin soft tissue. The results show that a cyclic accumulation of peak and valley strain, which can be terminologically called as ratchetting in terms of material science of metals, occurs in the porcine skin during cyclic tension-unloading, tension-tension and compression-unloading tests. Observed ratchetting of porcine skin depends on load level and loading orientation greatly and also presents remarkable rate dependence due to the viscosity of skin soft tissue. The ratchetting is much more remarkable during the test at lower loading rate than that at higher loading rate. Moreover, some basic properties of porcine skin were also investigated by monotonic tension, compression and creep tests in order to address the ratchetting more comprehensively. Finally, collagen fiber bundles in the porcine skin and their variation during monotonic and cyclic tension tests were observed microscopically in term of standard iron-hematoxylin staining method. The observations are useful to realize the micro-mechanism of ratchetting deformation. Copyright © 2010 Elsevier Ltd. All rights reserved.

  6. Fmoc-based synthesis of disulfide-rich cyclic peptides.

    Science.gov (United States)

    Cheneval, Olivier; Schroeder, Christina I; Durek, Thomas; Walsh, Phillip; Huang, Yen-Hua; Liras, Spiros; Price, David A; Craik, David J

    2014-06-20

    Disulfide-rich cyclic peptides have exciting potential as leads or frameworks in drug discovery; however, their use is faced with some synthetic challenges, mainly associated with construction of the circular backbone and formation of the correct disulfides. Here we describe a simple and efficient Fmoc solid-phase peptide synthesis (SPPS)-based method for synthesizing disulfide-rich cyclic peptides. This approach involves SPPS on 2-chlorotrityl resin, cyclization of the partially protected peptide in solution, cleavage of the side-chain protecting groups, and oxidization of cysteines to yield the desired product. We illustrate this method with the synthesis of peptides from three different classes of cyclic cystine knot motif-containing cyclotides: Möbius (M), trypsin inhibitor (T), and bracelet (B). We show that the method is broadly applicable to peptide engineering, illustrated by the synthesis of two mutants and three grafted analogues of kalata B1. The method reduces the use of highly caustic and toxic reagents and is better suited for high-throughput synthesis than previously reported methods for producing disulfide-rich cyclic peptides, thus offering great potential to facilitate pharmaceutical optimization of these scaffolds.

  7. Mechanical properties of concrete to cyclic uniaxial tensile loading ...

    Indian Academy of Sciences (India)

    The mechanical properties of concrete under cyclic tensile loading using square waveform, sine waveform and ramp waveform are studied. ... College of Civil and Transportation Engineering, Hobai University, Nanjing 210098, China; College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing ...

  8. Minimal cyclic codes of length p n q

    National Research Council Canada - National Science Library

    Sahni, Amita; Sehgal, Poonam Trama

    2012-01-01

    .... Explicit expressions for all the (d+1)n+2 primitive idempotents are obtained, d=gcd([phi](p.sup.n),[phi](q)), pa[currency](q-1). The dimension, generating polynomials and the minimum distance of the minimal cyclic codes of length...

  9. Centrifuge modelling of a laterally cyclic loaded pile

    DEFF Research Database (Denmark)

    Klinkvort, Rasmus Tofte; Leth, Caspar Thrane; Hededal, Ole

    2010-01-01

    A total number of 9 static and 6 cyclic centrifuge tests on laterally loaded piles in very dense, dry sand was erformed. The prototype dimensions of the piles were 1 meter in diameter and penetration depths varying from 6 to 10 meters. The static tests were used to investigate the initial subgrade...

  10. Experimental and theoretical investigations into the stability of cyclic aminals

    Directory of Open Access Journals (Sweden)

    Edgar Sawatzky

    2016-10-01

    Full Text Available Background: Cyclic aminals are core features of natural products, drug molecules and important synthetic intermediates. Despite their relevance, systematic investigations into their stability towards hydrolysis depending on the pH value are lacking.Results: A set of cyclic aminals was synthesized and their stability quantified by kinetic measurements. Steric and electronic effects were investigated by choosing appropriate groups. Both molecular mechanics (MM and density functional theory (DFT based studies were applied to support and explain the results obtained. Rapid decomposition is observed in acidic aqueous media for all cyclic aminals which occurs as a reversible reaction. Electronic effects do not seem relevant with regard to stability, but the magnitude of the conformational energy of the ring system and pKa values of the N-3 nitrogen atom.Conclusion: Cyclic aminals are stable compounds when not exposed to acidic media and their stability is mainly dependent on the conformational energy of the ring system. Therefore, for the preparation and work-up of these valuable synthetic intermediates and natural products, appropriate conditions have to be chosen and for application as drug molecules their sensitivity towards hydrolysis has to be taken into account.

  11. Crystalline hydrogen-bonded nanocolumns of cyclic thiourea octamers

    Energy Technology Data Exchange (ETDEWEB)

    Custelcean, Radu [ORNL; Engle, Nancy L [ORNL; Bonnesen, Peter V [ORNL

    2007-01-01

    A bis(thiourea) containing the 1,3-dimethyl-adamantane linker and t-Bu end groups self-assembles in the solid state into crystalline columnar aggregates made of hydrogen-bonded cyclic thiourea octamers with 2 nm diameters.

  12. Topology and symmetry of surface Majorana arcs in cyclic superconductors

    Science.gov (United States)

    Mizushima, Takeshi; Nitta, Muneto

    2018-01-01

    We study the topology and symmetry of surface Majorana arcs in superconductors with nonunitary "cyclic" pairing. Cyclic p -wave pairing may be realized in a cubic or tetrahedral crystal, while it is a candidate for the interior P32 superfluids of neutron stars. The cyclic state is an admixture of full gap and nodal gap with eight Weyl points and the low-energy physics is governed by itinerant Majorana fermions. We here show the evolution of surface states from Majorana cone to Majorana arcs under rotation of surface orientation. The Majorana cone is protected solely by an accidental spin rotation symmetry and fragile against spin-orbit coupling, while the arcs are attributed to two topological invariants: the first Chern number and one-dimensional winding number. Lastly, we discuss how topologically protected surface states inherent to the nonunitary cyclic pairing can be captured from surface probes in candidate compounds, such as U1 -xThxBe13 . We examine tunneling conductance spectra for two competitive scenarios in U1 -xThxBe13 —the degenerate Eu scenario and the accidental scenario.

  13. 21 CFR 862.1230 - Cyclic AMP test system.

    Science.gov (United States)

    2010-04-01

    ...) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems § 862... measure the level of adenosine 3′, 5′-monophosphate (cyclic AMP) in plasma, urine, and other body fluids... hypercalcemia (elevated levels of serum calcium.) (b) Classification. Class II. ...

  14. Computational design of disulfide cyclic peptide as potential ...

    African Journals Online (AJOL)

    This research studied and evaluated the interaction of ligands and the enzyme in the hydrate state using molecular dynamics simulations at two different temperatures. Simulations were performed using two disulfide cyclic peptide inhibitors KRK and RKR, along with one linear peptide Bz-Nle-K-R-R-H as standard ligand.

  15. Characterization of cyclical phases in the manufacturing industry in Spain

    Directory of Open Access Journals (Sweden)

    Mercè Sala

    2014-09-01

    Full Text Available 120 Purpose: The purpose of this paper is to characterize the cyclical phases of the manufacturing industry in Spain and detect which industries have more influence on the Spanish business cycle. We assume that economic growth is a priority; we are going to determine which industries have a more/less appropriate cyclical behavior according this priority. We analyze if the industries with better cyclical behavior are the ones that achieve greater co-movement with the business cycle of the Spanish economy, as this means they have a positive influence on economic activity. Design/methodology/approach: We examine the disaggregated quarterly IPI data of 16 manufacturing industries. Our methodology follows three steps. Firstly, we define cycle turning points; we follow the Harding and Pagan (2002 methodology. Secondly, we characterize the cyclical phases of the manufacturing industries in terms of duration, amplitude, deepness and steepness. We also determine the degree of inter-industrial cyclical synchronization and between industries in the cycle of the Spanish economy. This analysis is performed in two ways. On the one hand, we use the concordance index and the correlation coefficient. On the other hand, we work with indicators based on a consistency table. In the Third step, we apply a multi-objective methodology, specifically the compromise programming, to determine which industries have a more/less appropriate cyclical behavior according to the growth priority. Findings and Originality/value: The business cycle of the Spanish economy is positively influenced by high- and medium-tech industries, which have demonstrated their competitive capacity in international markets, and by medium- low-tech industries, with major strengths in R&D, and in survival and consolidation strategies. These results enable manufacturing industries to exert a positive effect on the business cycle that is weakened because many of them show a high correlation between

  16. Cyclic nucleotide phosphodiesterases in heart and vessels: A therapeutic perspective.

    Science.gov (United States)

    Bobin, Pierre; Belacel-Ouari, Milia; Bedioune, Ibrahim; Zhang, Liang; Leroy, Jérôme; Leblais, Véronique; Fischmeister, Rodolphe; Vandecasteele, Grégoire

    2016-01-01

    Cyclic nucleotide phosphodiesterases (PDEs) degrade the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), thereby regulating multiple aspects of cardiac and vascular muscle functions. This highly diverse class of enzymes encoded by 21 genes encompasses 11 families that are not only responsible for the termination of cyclic nucleotide signalling, but are also involved in the generation of dynamic microdomains of cAMP and cGMP, controlling specific cell functions in response to various neurohormonal stimuli. In the myocardium and vascular smooth muscle, the PDE3 and PDE4 families predominate, degrading cAMP and thereby regulating cardiac excitation-contraction coupling and smooth muscle contractile tone. PDE3 inhibitors are positive inotropes and vasodilators in humans, but their use is limited to acute heart failure and intermittent claudication. PDE5 is particularly important for the degradation of cGMP in vascular smooth muscle, and PDE5 inhibitors are used to treat erectile dysfunction and pulmonary hypertension. There is experimental evidence that these PDEs, as well as other PDE families, including PDE1, PDE2 and PDE9, may play important roles in cardiac diseases, such as hypertrophy and heart failure, as well as several vascular diseases. After a brief presentation of the cyclic nucleotide pathways in cardiac and vascular cells, and the major characteristics of the PDE superfamily, this review will focus on the current use of PDE inhibitors in cardiovascular diseases, and the recent research developments that could lead to better exploitation of the therapeutic potential of these enzymes in the future. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  17. Cyclic delivery scheduling to customers with different priorities

    Directory of Open Access Journals (Sweden)

    Katarzyna Zofia Gdowska

    2013-12-01

    Full Text Available Background: In this paper a cyclic delivery scheduling problem for customers with different priorities is presented. Shops, which are provided with deliveries, are occasionally located in places which are crucial for the proper flow of traffic. In such places coordination of deliveries is crucial; therefore it allows to completely eliminate the phenomenon of the simultaneous arrivals of suppliers. Methods: In this paper the cyclic delivery scheduling problem for customers with different priorities was presented. To this theoretical problem a mix integer programming model was developed. Specific approach to the cyclic delivery scheduling problem is inspired by timetabling problem for urban public transport. Results: Mixed integer programming model was employed for solving four cases of cyclic delivery scheduling problem for customers with different priorities. When the value of the synchronization priority assigned to a single customer raised then the total number of synchronizations in the whole network decreased. In order to compare solutions a synchronization rate was utilized. A simple factor was utilized - the proportion of number of synchronizations of deliveries to a given customer to the total number of synchronizations obtained for the whole network. When the value of synchronization priority raised then the value of synchronization rate of this customer improved significantly. Conclusions: The mixed integer programming model for the cyclic delivery scheduling problem for customers with different priorities presented in this paper can be utilized for generating schedules of serving customers located in places where only one delivery can be received and unloaded at one go and where there is no space for other suppliers to wait in a queue. Such a schedule can be very useful for organizing deliveries to small shops united in a franchising network, since they operate in a way that is very similar to the network presented in this paper

  18. STRUCTURE FORMATION OF HYPOEUTECTOID CONSTRUCTIONS STEELS AT CARBONITRIDING WITH LOCAL INDUCTION CYCLIC HEATING

    Directory of Open Access Journals (Sweden)

    G. A. Tkachenko

    2010-01-01

    Full Text Available Improvement of mechanical characteristics of details of the soil-cultivating car. Structurization at cyclic heating of steels. The reasons of an intensification of diffusion at cyclic heating. Structure crushing, impact strength and hardness increase.

  19. Plasma Membrane Cyclic Nucleotide Gated Calcium Channels Control Land Plant Thermal Sensing and Acquired Thermotolerance

    National Research Council Canada - National Science Library

    Andrija Finka; America Farinia Henriquez Cuendet; Frans J.M. Maathuis; Younousse Saidi; Pierre Goloubinoff

    2012-01-01

    .... Here, we found that the cyclic nucleotide gated calcium channel (CNGC) CNGCb gene from Physcomitrella patens and its Arabidopsis thaliana ortholog CNGC2, encode a component of cyclic nucleotide gated Ca²...

  20. Factors associated with early cyclicity in postpartum dairy cows.

    Science.gov (United States)

    Vercouteren, M M A A; Bittar, J H J; Pinedo, P J; Risco, C A; Santos, J E P; Vieira-Neto, A; Galvão, K N

    2015-01-01

    The objective of this study was to evaluate factors associated with resumption of ovarian cyclicity within 21 days in milk (DIM) in dairy cows. Cows (n=768) from 2 herds in north Florida had their ovaries scanned at 17±3, 21±3, and 24±3 DIM. Cows that had a corpus luteum ≥20mm at 17±3 or at 21±3 DIM or that had a corpus luteum metritis, mastitis, digestive problems, lameness, body weight loss, dry period length, and average daily milk yield. Body condition was scored at 17±3 DIM. Multivariable mixed logistic regression analysis was performed using the GLIMMIX procedure of SAS. Variables with P≤0.2 were considered in each model. Herd was included as a random variable. Three models were constructed: model 1 included all cows, model 2 included only cows from dairy 1 that had daily body weights available, and model 3 included only multiparous cows with a previous dry period length recorded. In model 1, variables associated with greater cyclicity by 21±3 DIM were calving in the summer and fall rather than in the winter or spring, being multiparous rather than primiparous, and not having metabolic or digestive problems. In model 2, variables associated with greater cyclicity by 21±3 DIM were calving in the summer and fall, not having metritis or digestive problems and not losing >28 kg of BW within 14 DIM. In model 3, variables associated with greater cyclicity by 21±3 DIM were absence of metabolic problems and dry period ≤76 d. In summary, cyclicity by 21±3 DIM was negatively associated with calving in winter or spring, primiparity, metritis, metabolic or digestive problems, loss of >28 kg of body weight, and a dry period >76d. Strategies preventing extended dry period length and loss of BW, together with reductions in the incidence of metritis as well as metabolic and digestive problems should improve early cyclicity postpartum. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  1. Chemotaxis to cyclic AMP and folic acid is mediated by different G proteins in Dictyostelium discoideum

    NARCIS (Netherlands)

    Kesbeke, Fanja; Haastert, Peter J.M. van; Wit, René J.W. de; Snaar-Jagalska, B. Ewa

    1990-01-01

    Mutant Frigid A (fgdA) of Dictyostelium discoideum is defective in a functional Gα2 subunit of a G protein and is characterized by a complete blockade of the cyclic AMP-mediated sensory transduction steps, including cyclic AMP relay, chemotaxis and the cyclic GMP response. Folic acid-mediated

  2. Cyclic voltammograms for H on Pt(111) and Pt(100) from first principles

    DEFF Research Database (Denmark)

    Karlberg, Gustav; Jaramillo, Thomas; Skulason, Egill

    2007-01-01

    Cyclic voltammetry is a fundamental experimental method for characterizing electrochemical surfaces. Despite its wide use, a way to quantitatively and directly relate cyclic voltammetry to ab initio calculations has been lacking. We derive the cyclic voltammogram for H on Pt(111) and Pt(100), based...

  3. Residual Stresses Analysis Methodology During Cyclic Plastic Deformation Carbon Steel

    Directory of Open Access Journals (Sweden)

    Vladislav OCHODEK

    2016-12-01

    Full Text Available One of the trends in development of new metal materials, respectively the increase of their mechanical properties, is the use of cyclical plastic deformation. Evaluation of resulting properties of given materials conducted only at the end of the process does not, however, enable to phase individual steps of the cyclical process in order to optimize technological parameters. A very suitable approach to describe the behaviour of materials during repeated plastic deformation seems to consist in a non-destructive analysis of residual stresses. The paper describes the method of analysis of residual stress based on the Barkhausen noise which is applied in the process of increasing mechanical properties of steel plates using the DRECE (Dual Rolling Equal Channel Extrusion method.

  4. Kolkata Paise Restaurant Problem and the Cyclically Fair Norm

    Science.gov (United States)

    Banerjee, Priyodorshi; Mitra, Manipushpak; Mukherjee, Conan

    In this paper we revisit the Kolkata Paise Restaurant problem by allowing for a more general (but common) preference of the n customers defined over the set of n restaurants. This generalization allows for the possibility that each pure strategy Nash equilibrium differs from the Pareto efficient allocation. By assuming that n is small and by allowing for mutual interaction across all customers we design strategies to sustain cyclically fair norm as a sub-game perfect equilibrium of the Kolkata Paise Restaurant problem. We have a cyclically fair norm if n strategically different Pareto efficient strategies are sequentially sustained in a way such that each customer gets serviced in all the n restaurants exactly once between periods 1 and n and then again the same process is repeated between periods (n+1) and 2n and so on.

  5. Improvements of cyclic somatic embryogenesis of cassava (Manihot esculenta Crantz).

    Science.gov (United States)

    Raemakers, C J; Schavemaker, C M; Jacobsen, E; Visser, R G

    1993-02-01

    In cassava a cyclic system of somatic embryogenesis was developed. Primary (torpedo shaped or germinated) embryos, originating from leaf lobes, could only be obtained after culture on solid medium. Cyclic embryos, originating from embryos, could be obtained in both liquid and on solid medium. The production of embryos in liquid medium was distinctly higher, faster and more synchronized than on solid medium. Lower densities and fragmentation of starting embryos improved the production significantly. The highest production found was 32.1 embryos per initial embryo. In all treatments the explants initiated multiple embryos. The production of single embryos was achieved by pressing starting embryos through a fine meshed sieve, indicating that embryos can be produced from a piece of tissue with a restricted number of cells. The shoot conversion rate of embryos from liquid medium was comparable with that of embryos from solid medium.

  6. TideWatch: Fingerprinting the cyclicality of big data workloads

    KAUST Repository

    Williams, Daniel W.

    2014-04-01

    Intrinsic to \\'big data\\' processing workloads (e.g., iterative MapReduce, Pregel, etc.) are cyclical resource utilization patterns that are highly synchronized across different resource types as well as the workers in a cluster. In Infrastructure as a Service settings, cloud providers do not exploit this characteristic to better manage VMs because they view VMs as \\'black boxes.\\' We present TideWatch, a system that automatically identifies cyclicality and similarity in running VMs. TideWatch predicts period lengths of most VMs in Hadoop workloads within 9% of actual iteration boundaries and successfully classifies up to 95% of running VMs as participating in the appropriate Hadoop cluster. Furthermore, we show how TideWatch can be used to improve the timing of VM migrations, reducing both migration time and network impact by over 50% when compared to a random approach. © 2014 IEEE.

  7. Identification of cyclic nucleotide gated channels using regular expressions

    KAUST Repository

    Zelman, Alice K.

    2013-09-03

    Cyclic nucleotide-gated channels (CNGCs) are nonselective cation channels found in plants, animals, and some bacteria. They have a six-transmembrane/one- pore structure, a cytosolic cyclic nucleotide-binding domain, and a cytosolic calmodulin-binding domain. Despite their functional similarities, the plant CNGC family members appear to have different conserved amino acid motifs within corresponding functional domains than animal and bacterial CNGCs do. Here we describe the development and application of methods employing plant CNGC-specific sequence motifs as diagnostic tools to identify novel candidate channels in different plants. These methods are used to evaluate the validity of annotations of putative orthologs of CNGCs from plant genomes. The methods detail how to employ regular expressions of conserved amino acids in functional domains of annotated CNGCs and together with Web tools such as PHI-BLAST and ScanProsite to identify novel candidate CNGCs in species including Physcomitrella patens. © Springer Science+Business Media New York 2013.

  8. Constraining cyclic peptides to mimic protein structure motifs

    DEFF Research Database (Denmark)

    Hill, Timothy A.; Shepherd, Nicholas E.; Diness, Frederik

    2014-01-01

    Many proteins exert their biological activities through small exposed surface regions called epitopes that are folded peptides of well-defined three-dimensional structures. Short synthetic peptide sequences corresponding to these bioactive protein surfaces do not form thermodynamically stable...... protein-like structures in water. However, short peptides can be induced to fold into protein-like bioactive conformations (strands, helices, turns) by cyclization, in conjunction with the use of other molecular constraints, that helps to fine-tune three-dimensional structure. Such constrained cyclic...... peptides can have protein-like biological activities and potencies, enabling their uses as biological probes and leads to therapeutics, diagnostics and vaccines. This Review highlights examples of cyclic peptides that mimic three-dimensional structures of strand, turn or helical segments of peptides...

  9. Bending cyclic load test for crystalline silicon photovoltaic modules

    Science.gov (United States)

    Suzuki, Soh; Doi, Takuya; Masuda, Atsushi; Tanahashi, Tadanori

    2018-02-01

    The failures induced by thermomechanical fatigue within crystalline silicon photovoltaic modules are a common issue that can occur in any climate. In order to understand these failures, we confirmed the effects of compressive or tensile stresses (which were cyclically loaded on photovoltaic cells and cell interconnect ribbons) at subzero, moderate, and high temperatures. We found that cell cracks were induced predominantly at low temperatures, irrespective of the compression or tension applied to the cells, although the orientation of cell cracks was dependent on the stress applied. The fracture of cell interconnect ribbons was caused by cyclical compressive stress at moderate and high temperatures, and this failure was promoted by the elevation of temperature. On the basis of these results, the causes of these failures are comprehensively discussed in relation to the viscoelasticity of the encapsulant.

  10. Cyclic models of the relativistic universe: the early history

    CERN Document Server

    Kragh, Helge

    2013-01-01

    Within the framework of relativistic cosmology oscillating or cyclic models of the universe were introduced by A. Friedmann in his seminal paper of 1922. With the recognition of evolutionary cosmology in the 1930s this class of closed models attracted considerable interest and was investigated by several physicists and astronomers. Whereas the Friedmann-Einstein model exhibited only a single maximum value, R. Tolman argued for an endless series of cycles. After World War II, cyclic or pulsating models were suggested by W. Bonnor and H. Zanstra, among others, but they remained peripheral to mainstream cosmology. The paper reviews the development from 1922 to the 1960s, paying particular attention to the works of Friedmann, Einstein, Tolman and Zanstra. It also points out the role played by bouncing models in the emergence of modern big-bang cosmology.

  11. Cyclic variations of the period and luminosity of SV Camelopardalis

    Science.gov (United States)

    Manzoori, D.

    2016-06-01

    New standardized V-band light curves (LCs) for the eclipsing binary SV Cam have been modeled using the PHOEBE program (v. 0.31a). Absolute parameters of the stellar components were then determined, enabling them to be positioned on the mass-radius diagram. Analysis of eclipse minima timing data (O-C diagrams) indicated two cyclic periods of 48.0 and 23.3 yr. These cyclic variations of the orbital period are interpreted in terms of motion of a third body around the system and magnetic activity cycle modulating the orbital period of SV Cam via the Applegate (1992) mechanism. The use of the Applegate model for SV Cam has been checked by examining the long term brightness variation and calculating some important parameters of this system. The results of these calculations favor the modulation of the orbital period by the Applegate mechanism.

  12. A compact cyclic plasticity model with parameter evolution

    DEFF Research Database (Denmark)

    Krenk, Steen; Tidemann, L.

    2017-01-01

    by the Armstrong–Frederick model, contained as a special case of the present model for a particular choice of the shape parameter. In contrast to previous work, where shaping the stress-strain loops is derived from multiple internal stress states, this effect is here represented by a single parameter......The paper presents a compact model for cyclic plasticity based on energy in terms of external and internal variables, and plastic yielding described by kinematic hardening and a flow potential with an additive term controlling the nonlinear cyclic hardening. The model is basically described by five......, and it is demonstrated that this simple formulation enables very accurate representation of experimental results. An extension of the theory to account for model parameter evolution effects, e.g. in the form of changing yield level, is included in the form of extended evolution equations for the model parameters...

  13. Application of cyclic fluorocarbon/argon discharges to device patterning

    Energy Technology Data Exchange (ETDEWEB)

    Metzler, Dominik, E-mail: dmetzler@umd.edu [IBM T. J. Watson Research Center, Yorktown Heights, New York 10598 and Department of Materials Science and Engineering, and Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20740 (United States); Uppireddi, Kishore; Bruce, Robert L.; Miyazoe, Hiroyuki; Zhu, Yu; Price, William; Sikorski, Ed S.; Engelmann, Sebastian U.; Joseph, Eric A. [IBM T. J. Watson Research Center, Yorktown Heights, New York 10598 (United States); Li, Chen [Department of Physics, and Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20740 (United States); Oehrlein, Gottlieb S. [Department of Materials Science and Engineering, and Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20740 (United States)

    2016-01-15

    With increasing demands on device patterning to achieve smaller critical dimensions and pitches for the 5 nm node and beyond, the need for atomic layer etching (ALE) is steadily increasing. In this work, a cyclic fluorocarbon/Ar plasma is successfully used for ALE patterning in a manufacturing scale reactor. Self-limited etching of silicon oxide is observed. The impact of various process parameters on the etch performance is established. The substrate temperature has been shown to play an especially significant role, with lower temperatures leading to higher selectivity and lower etch rates, but worse pattern fidelity. The cyclic ALE approach established with this work is shown to have great potential for small scale device patterning, showing self-limited etching, improved uniformity and resist mask performance.

  14. STUDY OF ELECTROPOLIMERIZATION PROCESSES OF PYRROLE BY CYCLIC VOLTAMMETRIC TECHNIQUE

    Directory of Open Access Journals (Sweden)

    Adhitasari Suratman

    2010-06-01

    Full Text Available Electropolymerization processes and electrochemical properties of polypyrrole as electroactive polymer have been studied by cyclic voltammetric technique. Pyrrole was electropolymerized to form polypyrrole in water-based solvent containing sodium perchlorate as supporting electrolyte in several pH values. The pH of the solutions were varied by using Britton Robinson buffer. The results showed that oxidation potential limit of electropolymerization processes of pyrrole was 1220 mV vs Ag/AgCl reference electrode. It can be seen that cyclic voltammetric respon of polypyrrole membrane that was prepared by electropolymerization processes of pyrrole at the scanning rate of 100 mV/s was stable. While the processes of pyrrole electropolymerization carried out at the variation of pH showed that the best condition was at the pH range of 2 - 6.   Keywords: polypyrolle, electropolymer, voltammetric technique

  15. Species-specific aggregation factor in sponges. VII. Its effect on cyclic amp and cyclic gmp metabolism in cells of Geodia cydonium.

    Science.gov (United States)

    Müller, W E; Müller, I; Zahn, R K; Kurelec, B

    1978-01-01

    In dissociated single cells from the sponge Geodia cydonium, DNA synthesis is initiated after incubation with a homologous, soluble aggregation factor. During the DNA-initiation phase the cyclic AMP- and cyclic GMP levels vary drastically; the cyclic AMP content drops from 2.2 pmol/10(6) cells to 0.3 pmol/10(6) cells while the cyclic GMP content increases from 0.6 pmol to 3.7 pmol/10(6) cells. The activity of neither the adenylate cyclase nor of the guanylate cyclase isolated from cells which have been incubated for different periods of time with the aggregation factor, is changed. The soluble as well as the particulate enzyme activities were checked in vitro. The cyclic nucleotide receptors have been isolated from the sponge cells and characterized with respect to their molecular weight, dissociation constant for cyclic AMP or cyclic GMP and intracellular concentration. None of these parameters are altered during aggregation factor-mediated DNA initiation. From these data it is concluded that the regulation of cyclic nucleotide levels is a consequence of a changed activity of nucleotide cyclases or of phosphodiesterases, but this is presumably not caused by a changed rate of synthesis of nucleotide cyclases or of cyclic nucleotide receptors.

  16. Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.

    Science.gov (United States)

    Maurice, D H; Haslam, R J

    1990-05-01

    We investigated the roles of cyclic GMP and cyclic AMP in the inhibition of rabbit platelet aggregation and degranulation by two nitrovasodilators, sodium nitroprusside (SNP) and 3-morpholinosydnonimine (SIN-1; the active metabolite of molsidomine), with particular reference to the synergistic interaction of these drugs with prostaglandin E1 (PGE1). Changes in platelet cyclic [3H]GMP and cyclic [3H]AMP were measured by rapid and sensitive prelabeling techniques, the validity of which were confirmed by radioimmunoassays. Incubation of the platelets with 0.1 to 10 microM SNP alone for 0.5 min caused progressively greater inhibitions of platelet function associated with large dose-dependent increases in cyclic [3H]GMP and 1.4- to 3.0-fold increases in cyclic [3H]AMP. However, addition of SNP with the adenylate cyclase activator, PGE1, at a concentration of the latter that had little effect alone, caused much larger increases in cyclic [3H]AMP and greatly enhanced the inhibition of platelet aggregation. SIN-1 had effects similar to those of SNP, although it was less active. The adenylate cyclase inhibitor 2',5'-dideoxyadenosine (DDA) diminished the increases in cyclic [3H]AMP caused by SNP or SIN-1 in both the presence and absence of PGE1 but reduced the inhibition of platelet function caused by the nitrovasodilators only in the presence of PGE1. These results suggest that, although cyclic GMP may mediate the inhibition of rabbit platelet function by high concentrations of nitrovasodilators added alone, the synergistic interaction of lower concentrations with PGE1 depends on an enhanced accumulation of cyclic AMP. Synergistic effects on cyclic [3H]AMP accumulation were also observed on incubation of platelets with SNP and adenosine, another activator of adenylate cyclase. Hemoglobin, which binds nitric oxide, blocked or reversed the increases in both cyclic [3H]GMP and cyclic [3H]AMP in platelets caused by the nitrovasodilators added either alone or with PGE1

  17. Cyclic elasto-viscoplastic model for asphalt concrete materials

    OpenAIRE

    Nguyen, DT; Nedjar, B.; P. Tamagny

    2007-01-01

    These last few years, many interests have been devoted to the study of rutting problems. In fact, under high traffic loadings together with the extreme environmental conditions, permanent deformations of asphalt pavements appear and become more and more severe demanding more efforts on developing suitable predictive models. In this paper, a three-dimensional elasto-viscoplasticity model is developed and applied to describe the behaviour of asphalt concrete materials under cyclic loadings. The...

  18. Stochastic effects on biodiversity in cyclic coevolutionary dynamics

    CERN Document Server

    Reichenbach, Tobias; Frey, Erwin

    2008-01-01

    Finite-size fluctuations arising in the dynamics of competing populations may have dramatic influence on their fate. As an example, in this article, we investigate a model of three species which dominate each other in a cyclic manner. Although the deterministic approach predicts (neutrally) stable coexistence of all species, for any finite population size, the intrinsic stochasticity unavoidably causes the eventual extinction of two of them.

  19. Effect of Cyclic Carbonation on Chloride Ingression in GGBS Concrete

    OpenAIRE

    Backus, Jonathon; McPolin, Daniel

    2016-01-01

    Carbonation and chloride ingress are the two main causes of corrosion in reinforced concrete structures. An investigation to monitor the ingress of chlorides and the effect of carbonation on chloride ingression during an accelerated 12 month cyclic wetting and drying exposure regime that simulates conditions in which multiple mode transport mechanisms are active was conducted on ground granulated blast furnace slag (GGBS) concrete. The penetration of chloride and carbon dioxide was evaluated ...

  20. Cyclic spectra for wavelength-routed optical networks.

    Science.gov (United States)

    Corcoran, Bill; Geng, Zihan; Rozental, Valery; Lowery, Arthur J

    2017-03-15

    We propose occupying the guard bands in closely spaced WDM systems with redundant signal spectral components to increase tolerance to frequency misalignment and channel shaping from multiplexing elements. By cyclically repeating the spectrum of a modulated signal, we show improved tolerance to impairments due to add/drop multiplexing with a commercial wavelength selective switch in systems using 5%-20% guard bands on a 50 GHz DWDM grid.

  1. Higher Genus Abelian Functions Associated with Cyclic Trigonal Curves

    Directory of Open Access Journals (Sweden)

    Matthew England

    2010-03-01

    Full Text Available We develop the theory of Abelian functions associated with cyclic trigonal curves by considering two new cases. We investigate curves of genus six and seven and consider whether it is the trigonal nature or the genus which dictates certain areas of the theory. We present solutions to the Jacobi inversion problem, sets of relations between the Abelian function, links to the Boussinesq equation and a new addition formula.

  2. A cytotoxic cyclic heptapeptide from the seeds of Annona cherimola.

    Science.gov (United States)

    Wélé, Alassane; Zhang, Yanjun; Ndoye, Idrissa; Brouard, Jean-Paul; Pousset, Jean-Louis; Bodo, Bernard

    2004-09-01

    From a methanol extract of the seeds of Annona cherimola, a new cyclic heptapeptide, cherimolacyclopeptide C, has been isolated. The structure was elucidated on the basis of the MS/MS fragmentation using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR experiments, and chemical degradation. Cherimolacyclopeptide C exhibited significant in vitro cytotoxic activity against KB cells, with an IC(50) value of 0.072 microM.

  3. Membrane-targeted self-assembling cyclic peptide nanotubes.

    Science.gov (United States)

    Rodríguez-Vázquez, Nuria; Ozores, H Lionel; Guerra, Arcadio; González-Freire, Eva; Fuertes, Alberto; Panciera, Michele; Priegue, Juan M; Outeiral, Juan; Montenegro, Javier; Garcia-Fandino, Rebeca; Amorin, Manuel; Granja, Juan R

    2014-01-01

    Peptide nanotubes are novel supramolecular nanobiomaterials that have a tubular structure. The stacking of cyclic components is one of the most promising strategies amongst the methods described in recent years for the preparation of nanotubes. This strategy allows precise control of the nanotube surface properties and the dimensions of the tube diameter. In addition, the incorporation of 3- aminocycloalkanecarboxylic acid residues in the nanotube-forming peptides allows control of the internal properties of the supramolecular tube. The research aimed at the application of membrane-interacting self-assembled cyclic peptide nanotubes (SCPNs) is summarized in this review. The cyclic peptides are designed to interact with phospholipid bilayers to induce nanotube formation. The properties and orientation of the nanotube can be tuned by tailoring the peptide sequence. Hydrophobic peptides form transmembrane pores with a hydrophilic orifice, the nature of which has been exploited to transport ions and small molecules efficiently. These synthetic ion channels are selective for alkali metal ions (Na(+), K(+) or Cs(+)) over divalent cations (Ca(2+)) or anions (Cl(-)). Unfortunately, selectivity was not achieved within the series of alkali metal ions, for which ion transport rates followed the diffusion rates in water. Amphipathic peptides form nanotubes that lie parallel to the membrane. Interestingly, nanotube formation takes place preferentially on the surface of bacterial membranes, thus making these materials suitable for the development of new antimicrobial agents.

  4. Continuous Cellulosic Bioethanol Fermentation by Cyclic Fed-Batch Cocultivation

    Science.gov (United States)

    Jiang, He-Long; He, Qiang; He, Zhili; Hemme, Christopher L.; Wu, Liyou

    2013-01-01

    Cocultivation of cellulolytic and saccharolytic microbial populations is a promising strategy to improve bioethanol production from the fermentation of recalcitrant cellulosic materials. Earlier studies have demonstrated the effectiveness of cocultivation in enhancing ethanolic fermentation of cellulose in batch fermentation. To further enhance process efficiency, a semicontinuous cyclic fed-batch fermentor configuration was evaluated for its potential in enhancing the efficiency of cellulose fermentation using cocultivation. Cocultures of cellulolytic Clostridium thermocellum LQRI and saccharolytic Thermoanaerobacter pseudethanolicus strain X514 were tested in the semicontinuous fermentor as a model system. Initial cellulose concentration and pH were identified as the key process parameters controlling cellulose fermentation performance in the fixed-volume cyclic fed-batch coculture system. At an initial cellulose concentration of 40 g liter−1, the concentration of ethanol produced with pH control was 4.5-fold higher than that without pH control. It was also found that efficient cellulosic bioethanol production by cocultivation was sustained in the semicontinuous configuration, with bioethanol production reaching 474 mM in 96 h with an initial cellulose concentration of 80 g liter−1 and pH controlled at 6.5 to 6.8. These results suggested the advantages of the cyclic fed-batch process for cellulosic bioethanol fermentation by the cocultures. PMID:23275517

  5. Polarization phase-shifting cyclic Jamin shearing interferometer

    Science.gov (United States)

    Wang, Lijuan; Liu, Liren; Sun, Jianfeng; Zhou, Yu; Dai, Enwen; Wu, Yapeng

    2012-10-01

    In the inter-satellite laser communication, the laser beam transmitted from the optical terminals is required to be highly collimated and its divergence approaches diffraction-limit. For testing the diffraction-limit wavefront, a polarization phase-shifting cyclic Jamin shearing interferometer is proposed. It is composed of a Jamin plate with a PBS film coated on its front surface, a right-angle prism reflecting beams two times, a shearing plate shearing beams by its rotation and a polarization phase shifter. The laser beam to be test is incident on the Jamin plate and gives rise to two interference beams with mutually perpendicular polarization directions by the PBS film. The two beams falls on the right-angle prism before or after passing through the shearing plate. With reflection of the right-angle prism, a cyclic Jamin shearing interferometric light path is formed. Two emitted beams go into the polarization phase shifter to obtain phase-shifting interferograms. In this interferometer, the cyclic interferometric light path can eliminate error of the surface profile of the optical element and the effect of environment. The interferometer has polarization phase shifting function and its fringe visibility is high. Therefore the interferometer can obtain high accuracy with variable shearing amount. In experiments, phase-shifting interferograms are obtained and the usefulness of the interferometer is verified.

  6. Cyclic GMP recognition using ratiometric QD-fluorophore conjugate nanosensors.

    Science.gov (United States)

    Cywinski, Piotr J; Moro, Artur J; Löhmannsröben, Hans-Gerd

    2014-02-15

    Novel luminescent ratiometric nanosensors (QD-NAPTHs) were prepared based on cadmium telluride (CdTe655) quantum dots as luminescent nanoscaffolds with naphthyridine dyes as fluorescent receptors. This biosensing bifluorophoric nanosystem has been designed to achieve detection of guanosine 3',5'-cyclic monophosphate (cyclic GMP) in buffered media. Cyclic GMP is a secondary messenger that is an important factor for detecting cancer, diabetes and, cardiovascular diseases. Due to low concentration levels, even in pathological conditions, sensitive cGMP detection remains a challenge for modern biomedical diagnostics. Here, QD-NAPTH nanosensors were tested in the presence of a target nucleotide and with various structural cGMP analogues. Steady-state fluorescence spectroscopy was used to monitor a change in the nucleotide concentration. A 5-fold increase in naphthyridine fluorescence with a simultaneous decrease in QD luminescence was observed after adding 50 μM of cGMP. Using this novel nanosystem with ratiometric detection, it was possible to recognize cGMP with limit of detection (3σ) equal to 70 ng/ml. Moreover, the enhancement in fluorescence upon interaction with the target nucleotide constitutes a favourable approach towards the detection of cGMP in buffered media. These bifluorophoric nanosensors have a potential for application in fluorescence microscopy imaging and in-vitro assays. © 2013 Elsevier B.V. All rights reserved.

  7. Cyclic GMP mediates neurogenic relaxation in the bovine retractor penis muscle.

    OpenAIRE

    Bowman, A.; Drummond, A H

    1984-01-01

    Field stimulation of the non-adrenergic, non-cholinergic inhibitory nerves to the bovine isolated retractor penis muscle evoked a relaxation that was preceded by a rise in the tissue content of cyclic GMP. There was no change in the content of cyclic AMP. The selective cyclic GMP phosphodiesterase inhibitor, 2-o- propoxyphenyl -8- azapurin -6-one (M&B 22948), elevated the tissue's cyclic GMP content, and potentiated both the relaxation and the rise in cyclic GMP produced by inhibitory nerve s...

  8. Cyclic neutropenia in a cleft lip and palate patient: a case report.

    Science.gov (United States)

    Desai, Anil; Gopalkrishnan, K; Joshi, V K; Rao, C Bhasker

    2011-11-01

    Cleft lip and palate is the most common congenital anomaly. Its association with hematologic disorders is rarely reported. Cyclic neutropenia is a rare blood disorder that may occur spontaneously or has a genetic predisposition. Periodicity/recurrence of cyclic neutropenia has a cyclical pattern reoccurring in multiples of 7 days, usually at 21- or 28-day intervals between attacks, with the patient being fairly asymptomatic. There is no case in the literature that has reported the presence of cyclic neutropenia in cleft patients. We report a case of cleft patient associated with cyclic neutropenia. The clinical features, diagnosis, and course of management are described.

  9. The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

    DEFF Research Database (Denmark)

    Almblad, Henrik; Harrison, Joe J; Rybtke, Morten

    2015-01-01

    as a direct result of elevated c-di-GMP content. Overproduction of c-di-GMP causes a decrease in the transcription of virulence factor genes that are regulated by the global virulence regulator Vfr. The low level of Vfr-dependent transcription is caused by a low level of its coactivator, cyclic AMP (cAMP...... infection give rise to rugose small colony variants (RSCVs), which are hyper-biofilm-forming mutants that commonly possess mutations that increase production of the biofilm-promoting secondary messenger cyclic di-GMP (c-di-GMP). We show that RSCVs display a decreased production of acute virulence factors......), which is decreased in response to a high level of c-di-GMP. Mutations that cause reversion of the RSCV phenotype concomitantly reactivate Vfr-cAMP signaling. Attempts to uncover the mechanism underlying the observed c-di-GMP-mediated lowering of cAMP content provided evidence that it is not caused...

  10. Radiolabeled Cyclic RGD Peptide Bioconjugates as Radiotracers Targeting Multiple Integrins.

    Science.gov (United States)

    Liu, Shuang

    2015-08-19

    Angiogenesis is a requirement for tumor growth and metastasis. The angiogenic process depends on vascular endothelial cell migration and invasion, and is regulated by various cell adhesion receptors. Integrins are such a family of receptors that facilitate the cellular adhesion to and migration on extracellular matrix proteins in the intercellular spaces and basement membranes. Among 24 members of the integrin family, αvβ3 is studied most extensively for its role in tumor angiogenesis and metastasis. The αvβ3 is expressed at relatively low levels on epithelial cells and mature endothelial cells, but it is highly expressed on the activated endothelial cells of tumor neovasculature and some tumor cells. This restricted expression makes αvβ3 an excellent target to develop antiangiogenic drugs and diagnostic molecular imaging probes. Since αvβ3 is a receptor for extracellular matrix proteins with one or more RGD tripeptide sequence, many radiolabeled cyclic RGD peptides have been evaluated as "αvβ3-targeted" radiotracers for tumor imaging over the past decade. This article will use the dimeric and tetrameric cyclic RGD peptides developed in our laboratories as examples to illustrate basic principles for development of αvβ3-targeted radiotracers. It will focus on different approaches to maximize the radiotracer tumor uptake and tumor/background ratios. This article will also discuss some important assays for preclinical evaluations of integrin-targeted radiotracers. In general, multimerization of cyclic RGD peptides increases their integrin binding affinity and the tumor uptake and retention times of their radiotracers. Regardless of their multiplicity, the capability of cyclic RGD peptides to bind other integrins (namely, αvβ5, α5β1, α6β4, α4β1, and αvβ6) is expected to enhance the radiotracer tumor uptake due to the increased integrin population. The results from preclinical and clinical studies clearly show that radiolabeled cyclic RGD peptides

  11. Cyclic nucleotides and production of prostanoids in human varicose veins.

    Science.gov (United States)

    Nemcova, S; Gloviczki, P; Rud, K S; Miller, V M

    1999-11-01

    Experiments were designed to determine the production of prostacyclin and thromboxane and the activation of cyclic nucleotides in human varicose and nonvaricose veins and to determine whether these second messenger pathways were differentially activated by the venotropic extract of Ruscus aculeatus. The experiments were designed to characterize the activity of cyclic nucleotides and the production of prostaglandins in human varicose and nonvaricose veins. Segments of the greater saphenous veins and the adjacent tributaries were obtained from patients who underwent vein stripping and excision of primary varicose veins. The saphenous veins from the patients who underwent peripheral arterial bypass grafting were used as controls. The segments of veins were incubated in Krebs-Ringer bicarbonate solution in the presence of venotropic extract of Ruscus aculeatus (10(-3) g/mL) or in water-miscible organic solvent (dimethyl sulfoxide, 10(-3) g/mL), for 1, 5, and 10 minutes at 37 degrees C. The nonspecific phosphodiesterase inhibitor (3-isobutyl-1-methylxanthine, 10(-4) g/mL) was used to block cyclic nucleotide degradation in some samples. Tissue and media samples were collected. Tissue concentrations of both cyclic adenosine monophosphate and cyclic guanosine monophosphate (cAMP and cGMP, respectively) and media concentrations of 6-ketoprostaglandin-F(1)(alpha) (the stable metabolite of prostacyclin) and thromboxane B(2) (the stable metabolite of thromboxane A(2)) were measured by means of radioimmunoassay. Cyclooxygenase 2 was measured with Western blot analysis. The varicose veins showed greater levels of cAMP but not of cGMP at all time points as compared with the control veins. Prostanoid production was not significantly altered in the varicose veins. Stimulation with Ruscus aculeatus increased the cAMP concentration in the varicose veins but did not affect the cGMP levels. The ratio between 6-ketoprostaglandin-F(1)(alpha) and thromboxane B(2) was two-fold greater in

  12. Effects of Cyclic Loading on the Uniaxial Behavior of Nitinol

    Science.gov (United States)

    Schlun, M.; Zipse, A.; Dreher, G.; Rebelo, N.

    2011-07-01

    The widespread development and use of implants made from NiTi is accompanied by the publication of many NiTi material characterization studies. These publications have increased significantly the knowledge about the mechanical properties of NiTi. However, this knowledge also increased the complexity of the numerical simulation of NiTi implants or devices. This study is focused on the uniaxial behavior of NiTi tubing due to cyclic loading and had the goal to deliver both precise and application-oriented results. Single aspects of this study have already been published (Wagner in Ein Beitrag zur strukturellen und funktionalen Ermüdung von Drähten und Federn aus NiTi-Formgedaechtnislegierungen, Ph.D. Thesis, 2005; Eucken and Duerig in Acta Metall 37:2245-2252, 1989; Yawny et al. in Z Metallkd 96:608-618, 2005); however, there is no publication known that shows all the single effects combined in a "duty cycle case." It was of particular importance to summarize the main effects of pre-strain and subsequent small or large strain amplitudes on the material properties. The phenomena observed were captured in an extended Abaqus® Nitinol material model, presented by Rebelo et al. (A Material Model for the Cyclic Behavior of Nitinol, SMST Extended Abstracts 2010). The cyclic tensile tests were performed using a video extensometer to obtain accurate strain measurement on small electro-polished dog-bone specimen that were incorporated into a stent framework so that standard manufacturing methods could be used for the fabrication. This study indicates that a prestrain beyond 6% strain alters the transformation plateaus and if the cyclic displacement amplitude is large enough, additional permanent deformations are observed, the lower plateau and most notably the upper plateau change. The changes to the upper plateau are very interesting in the sense that an additional stress plateau develops: its "start stress" is lowered thereby creating a new plateau up to the highest level

  13. Studies on resilient modulus value from cyclic loading tests for cohesive soil

    Directory of Open Access Journals (Sweden)

    Sas Wojciech

    2017-06-01

    Full Text Available In this article the cyclic CBR test as a reference method in determination of resilient modulus (Mr is confronted with results of cyclic triaxial and unconfined uniaxial cyclic test. The main idea of conducted experiments is establish relationship between cyclic loading tests in testing of natural subsoil and road materials. The article shows results of investigation on cohesive soil, namely sandy silty clay, commonly problematic soil in Poland. The results of repeated loading triaxial test resilient modulus were displayed in order to compare them with cyclic CBR test results by using the Mr–Ө model. Some empirical correlation between factors obtained from triaxial test or uniaxial unconfined cyclic test and cyclic CBR test was introduced here. The behavior of resilient modulus was also examined in this paper.

  14. Cyclic nucleotides of canine antral smooth muscle. Effects of acetylcholine, catecholamines and gastrin.

    Science.gov (United States)

    Baur, S; Grant, B; Wooton, J

    1981-01-07

    1. The effects of acetylcholine, catecholamines and gastrin on the intracellular content of cyclic AMP and cyclic GMP in antral circular muscle have been determined. 2. Acetylcholine results in a significant but transient increase in intracellular cyclic GMP. 3. Isoproterenol and norepinephrine increase intracellular cyclic AMP. Based on half-maximal effective doses, isoproterenol is 2.7-times more effective than norepinephrine. The increase in intracellular cyclic AMP by both agents is inhibited by propranolol but not phentolamine, indicating that both agents act on the muscle cell by a beta-receptor-coupled mechanism. 4. Gastrin has no demonstrable effect on either cyclic AMP or cyclic GMP. This suggests that while gastrin and acetylcholine can produce a like myoelectric response in the muscle cell, the action of gastrin is mediated by a separate receptor, presumably on the muscle cell, and not by a release of acetylcholine.

  15. Activation of the adenylyl cyclase/cyclic AMP/protein kinase A pathway in endothelial cells exposed to cyclic strain

    Science.gov (United States)

    Cohen, C. R.; Mills, I.; Du, W.; Kamal, K.; Sumpio, B. E.

    1997-01-01

    The aim of this study was to assess the involvement of the adenylyl cyclase/cyclic AMP/protein kinase A pathway (AC) in endothelial cells (EC) exposed to different levels of mechanical strain. Bovine aortic EC were seeded to confluence on flexible membrane-bottom wells. The membranes were deformed with either 150 mm Hg (average 10% strain) or 37.5 mm Hg (average 6% strain) vacuum at 60 cycles per minute (0.5 s strain; 0.5 s relaxation) for 0-60 min. The results demonstrate that at 10% average strain (but not 6% average strain) there was a 1.5- to 2.2-fold increase in AC, cAMP, and PKA activity by 15 min when compared to unstretched controls. Further studies revealed an increase in cAMP response element binding protein in EC subjected to the 10% average strain (but not 6% average strain). These data support the hypothesis that cyclic strain activates the AC/cAMP/PKA signal transduction pathway in EC which may occur by exceeding a strain threshold and suggest that cyclic strain may stimulate the expression of genes containing cAMP-responsive promoter elements.

  16. Evaluation of the gas production economics of the gas hydrate cyclic thermal injection model. [Cyclic thermal injection

    Energy Technology Data Exchange (ETDEWEB)

    Kuuskraa, V.A.; Hammersheimb, E.; Sawyer, W.

    1985-05-01

    The objective of the work performed under this directive is to assess whether gas hydrates could potentially be technically and economically recoverable. The technical potential and economics of recovering gas from a representative hydrate reservoir will be established using the cyclic thermal injection model, HYDMOD, appropriately modified for this effort, integrated with economics model for gas production on the North Slope of Alaska, and in the deep offshore Atlantic. The results from this effort are presented in this document. In Section 1, the engineering cost and financial analysis model used in performing the economic analysis of gas production from hydrates -- the Hydrates Gas Economics Model (HGEM) -- is described. Section 2 contains a users guide for HGEM. In Section 3, a preliminary economic assessment of the gas production economics of the gas hydrate cyclic thermal injection model is presented. Section 4 contains a summary critique of existing hydrate gas recovery models. Finally, Section 5 summarizes the model modification made to HYDMOD, the cyclic thermal injection model for hydrate gas recovery, in order to perform this analysis.

  17. Spironolactone and topical retinoids in adult female cyclical acne.

    Science.gov (United States)

    Lessner, Erin; Fisher, Samantha; Kobraei, Katherina; Osleber, Michael; Lessner, Rebecca; Elliott, Lauren; Wesson, Stanton

    2014-02-01

    To access the efficacy of spironolactone and topical retinoids in the treatment of female cyclical acne. A retrospective chart review on 41 female patients age 19-57 years old with cyclical acne was performed. Patients were examined over the course of 2 to 102 months while taking 50 to 200 mg of spironolactone and topical tretinoin 0.025% or adapalene 0.1% cream. All were diagnosed with acne rated mild to severe, prior to treatment, and were started on an initial dose of 50 mg po daily. If significant improvement was not seen within the first 3-6 months, the dose was either held or increased in 25 mg increments every 3 months. Patients on oral and topical antibiotics, as well as patients on photodynamic therapy were excluded from the study. The response to treatment was rated on a 0-4 scale with 0 being no response and 4 corresponding to clear skin. One patient (2.4%) had no response to treatment. This patient was only on 50 mg po daily for only 2 months. Only 5 (12.2%) patients had minimal response to treatment and 9 (22.0%), 12 (29.3%), and 14 (34.1%) had a good, excellent, or clear response respectively. The study showed 26 (63.4%) women on treatment with spironolactone and topical retinoids had an excellent or clear outcome, and 35 (85.4%) were considered to have a good, excellent, or clear response. The addition of spironolactone to topical retinoid treatment suggests a superior response to retinoids alone in clearance of female adult cyclical acne.

  18. Radiolabeled cyclic RGD peptides as radiotracers for tumor imaging.

    Science.gov (United States)

    Shi, Jiyun; Wang, Fan; Liu, Shuang

    2016-01-01

    The integrin family comprises 24 transmembrane receptors, each a heterodimeric combination of one of 18α and one of 8β subunits. Their main function is to integrate the cell adhesion and interaction with the extracellular microenvironment with the intracellular signaling and cytoskeletal rearrangement through transmitting signals across the cell membrane upon ligand binding. Integrin αvβ3 is a receptor for the extracellular matrix proteins containing arginine-glycine-aspartic (RGD) tripeptide sequence. The αvβ3 is generally expressed in low levels on the epithelial cells and mature endothelial cells, but it is highly expressed in many solid tumors. The αvβ3 levels correlate well with the potential for tumor metastasis and aggressiveness, which make it an important biological target for development of antiangiogenic drugs, and molecular imaging probes for early tumor diagnosis. Over the last decade, many radiolabeled cyclic RGD peptides have been evaluated as radiotracers for imaging tumors by SPECT or PET. Even though they are called "αvβ3-targeted" radiotracers, the radiolabeled cyclic RGD peptides are also able to bind αvβ5, α5β1, α6β4, α4β1, and αvβ6 integrins, which may help enhance their tumor uptake due to the "increased receptor population." This article will use the multimeric cyclic RGD peptides as examples to illustrate basic principles for development of integrin-targeted radiotracers and focus on different approaches to maximize their tumor uptake and T/B ratios. It will also discuss important assays for pre-clinical evaluations of the integrin-targeted radiotracers, and their potential applications as molecular imaging tools for noninvasive monitoring of tumor metastasis and early detection of the tumor response to antiangiogenic therapy.

  19. Comparison of cyclic correlation algorithm implemented in matlab and python

    Science.gov (United States)

    Carr, Richard; Whitney, James

    Simulation is a necessary step for all engineering projects. Simulation gives the engineers an approximation of how their devices will perform under different circumstances, without hav-ing to build, or before building a physical prototype. This is especially true for space bound devices, i.e., space communication systems, where the impact of system malfunction or failure is several orders of magnitude over that of terrestrial applications. Therefore having a reliable simulation tool is key in developing these devices and systems. Math Works Matrix Laboratory (MATLAB) is a matrix based software used by scientists and engineers to solve problems and perform complex simulations. MATLAB has a number of applications in a wide variety of fields which include communications, signal processing, image processing, mathematics, eco-nomics and physics. Because of its many uses MATLAB has become the preferred software for many engineers; it is also very expensive, especially for students and startups. One alternative to MATLAB is Python. The Python is a powerful, easy to use, open source programming environment that can be used to perform many of the same functions as MATLAB. Python programming environment has been steadily gaining popularity in niche programming circles. While there are not as many function included in the software as MATLAB, there are many open source functions that have been developed that are available to be downloaded for free. This paper illustrates how Python can implement the cyclic correlation algorithm and com-pares the results to the cyclic correlation algorithm implemented in the MATLAB environment. Some of the characteristics to be compared are the accuracy and precision of the results, and the length of the programs. The paper will demonstrate that Python is capable of performing simulations of complex algorithms such cyclic correlation.

  20. Cyclic voiding cystouretrography without the use of fluoroscopic monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Kadioglu, Alev [ALKA Medical Imaging Center, Buyukdere Cad. Levent Apt. No: 36/16, 80200-Mecidiyekoy, Istanbul (Turkey)]. E-mail: alevkadioglu@yahoo.com; Mihmanli, Ismail [Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, 34300-Istanbul (Turkey); Kantarci, Fatih [Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, 34300-Istanbul (Turkey); Tekes, Aylin [ALKA Medical Imaging Center, Buyukdere Cad. Levent Apt. No: 36/16, 80200-Mecidiyekoy, Istanbul (Turkey); Uysal, Omer [Istanbul University, Cerrahpasa Medical Faculty, Department of Biostatistics, 34300-Istanbul (Turkey)

    2006-01-15

    Purpose: To determine whether cyclic voiding cystourethrography (VCUG) examinations can be performed without using real-time fluoroscopic monitoring. Materials and methods: VCUG examinations were performed in 209 children (133 girls and 76 boys). In each child, it was performed in a cyclic manner (three consecutive cycles) without using fluoroscopic monitoring and one radiograph was taken in each cycle of the examination. All patients were sedated by midazolam prior to examination. The degree of vesicoureteric reflux (VUR) was graded for each of the kidney ureter units (KUU) (total 418 KUU) separately. Statistical analysis included the comparison of the presence and absence of VUR and three ordinal-matched comparisons of each cycle. Results: VCUG was detected in 37.3% of the children (78/209) and 28.7% (120/418) of the KUU. The absence of or same degree of VUR in three consecutive cycles were obtained in 345 KUU and the agreement was calculated as 82.5%. The same degree and presence of reflux were found in 85 and 89 refluxing KUU, the same negative findings (absence of VUR) in 306 and 298 KUU, and discordant findings in 27 and 31 KUU (between the first and second and between first and third cycles), respectively. Therefore, the agreement was 93.5 and 92.5% between the first and second cycles (p = 0.70) and between the first and the third cycles (p = 0.15), respectively. Conclusion: Both the cyclic nature of this study and the results indicated that VCUG without real-time fluoroscopic monitoring could be used where adequate fluoroscopic examination is not possible for children in whom VUR detection is necessary and impacts treatment. However, the responsibility of pediatric radiologist always must also include the task to provide proper equipment for imaging children with suspected VUR.

  1. Smart Annotation of Cyclic Data Using Hierarchical Hidden Markov Models.

    Science.gov (United States)

    Martindale, Christine F; Hoenig, Florian; Strohrmann, Christina; Eskofier, Bjoern M

    2017-10-13

    Cyclic signals are an intrinsic part of daily life, such as human motion and heart activity. The detailed analysis of them is important for clinical applications such as pathological gait analysis and for sports applications such as performance analysis. Labeled training data for algorithms that analyze these cyclic data come at a high annotation cost due to only limited annotations available under laboratory conditions or requiring manual segmentation of the data under less restricted conditions. This paper presents a smart annotation method that reduces this cost of labeling for sensor-based data, which is applicable to data collected outside of strict laboratory conditions. The method uses semi-supervised learning of sections of cyclic data with a known cycle number. A hierarchical hidden Markov model (hHMM) is used, achieving a mean absolute error of 0.041 ± 0.020 s relative to a manually-annotated reference. The resulting model was also used to simultaneously segment and classify continuous, 'in the wild' data, demonstrating the applicability of using hHMM, trained on limited data sections, to label a complete dataset. This technique achieved comparable results to its fully-supervised equivalent. Our semi-supervised method has the significant advantage of reduced annotation cost. Furthermore, it reduces the opportunity for human error in the labeling process normally required for training of segmentation algorithms. It also lowers the annotation cost of training a model capable of continuous monitoring of cycle characteristics such as those employed to analyze the progress of movement disorders or analysis of running technique.

  2. Smart Annotation of Cyclic Data Using Hierarchical Hidden Markov Models

    Directory of Open Access Journals (Sweden)

    Christine F. Martindale

    2017-10-01

    Full Text Available Cyclic signals are an intrinsic part of daily life, such as human motion and heart activity. The detailed analysis of them is important for clinical applications such as pathological gait analysis and for sports applications such as performance analysis. Labeled training data for algorithms that analyze these cyclic data come at a high annotation cost due to only limited annotations available under laboratory conditions or requiring manual segmentation of the data under less restricted conditions. This paper presents a smart annotation method that reduces this cost of labeling for sensor-based data, which is applicable to data collected outside of strict laboratory conditions. The method uses semi-supervised learning of sections of cyclic data with a known cycle number. A hierarchical hidden Markov model (hHMM is used, achieving a mean absolute error of 0.041 ± 0.020 s relative to a manually-annotated reference. The resulting model was also used to simultaneously segment and classify continuous, ‘in the wild’ data, demonstrating the applicability of using hHMM, trained on limited data sections, to label a complete dataset. This technique achieved comparable results to its fully-supervised equivalent. Our semi-supervised method has the significant advantage of reduced annotation cost. Furthermore, it reduces the opportunity for human error in the labeling process normally required for training of segmentation algorithms. It also lowers the annotation cost of training a model capable of continuous monitoring of cycle characteristics such as those employed to analyze the progress of movement disorders or analysis of running technique.

  3. Differential model of macroeconomic growth with endogenic cyclicity

    Directory of Open Access Journals (Sweden)

    Mikhail I. Geraskin

    2017-09-01

    Full Text Available Objective to elaborate a mathematical model of economic growth taking into account the cyclical nature of macroeconomic dynamics with the model parameters based on the Russian economy statistics. Methods economic and mathematical modeling system analysis regression factor analysis econometric time series analysis. Results the article states that under unstable economic growth in Russia forecasting of strategic prospects of the Russian economy is one of the topical directions of scientific studies. Furthermore construction of predictive models should be based on multiple factors taking into account such basic concepts as the neoKeynesian HarrodDomar model Ramsey ndash Cass ndash Koopmans model S. V. Dubovskiyrsquos concept as well as the neoclassical growth model by R. Solow. They served as the basis for developing a multifactor differential economic growth model which is a modification of the neoclassical growth model by R. Solow taking into account the laborsaving and capitalsaving forms of scientifictechnical progress and the Keynesian concept of investment. The model parameters are determined based on the dynamics of actual GDP employment fixed assets and investments in fixed assets for 19652016 in Russia on the basis of official statistics. The generalized model showed the presence of longwave fluctuations that are not detected during the individual periods modeling. The cyclical nature of macroeconomic dynamics with a period of 54 years was found which corresponds to the parameters of long waves by N. D. Kondratiev. Basing on the model the macroeconomic growth forecast was generated which shows that after 2020 the increase of scientifictechnical progress will be negative. Scientific novelty a model is proposed of the scientifictechnical progress indicator showing the growth rate of the capital productivity ratio to the saving rate a differential model of macroeconomic growth is obtained which endogenously takes cyclicity into account

  4. Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications.

    Science.gov (United States)

    Lee, Yeji; Phat, Chanvorleak; Hong, Soon-Cheol

    2017-09-01

    Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti-inflammation, anti-proliferative, anti-hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and modes of action according to their structure such as cyclic oligopeptide, cyclic lipopeptide, cyclic glycopeptide and cyclic depsipeptide. The recent advances in application of the above-mentioned cyclic peptides were reported in dolastatins, soblidotin, didemnin B, aplidine, salinosporamide A, kahalalide F and bryostatin 1 and they are currently in clinical trials. These cyclic peptides are possible novel drugs discovered and developed from marine origin. Literature data concerning the potential properties of marine cyclic peptides were reviewed here, and the structural diversity and biological activities of marine cyclic peptides are discussed in relation to the molecular mechanisms of these marine cyclic peptides. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Cyclic sciatica caused by infiltrative endometriosis: MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Yekeler, Ensar; Kumbasar, Basak; Tunaci, Atadan; Barman, Ahmet; Tunaci, Mehtap [Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, 34390, Capa, Istanbul (Turkey); Bengisu, Ergin [Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul University, Istanbul (Turkey); Yavuz, Ekrem [Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, 34390, Capa, Istanbul (Turkey)

    2004-03-01

    Endometriosis, an important gynecological disorder of reproductive women, affects most commonly the ovaries and less frequently the gastrointestinal tract, chest, urinary tract, and soft tissues. Endometriosis classically appears on MRI as a mass with a large cystic component and variable signal intensities on T1- and T2-weighted images due to the presence of variable degradation of hemorrhagic products. Endometriosis in an atypical location, an infiltrative appearance and without cystic-hemorrhagic components has rarely been described. We report on a 33-year-old woman with cyclic sciatica due to histologically documented infiltrative endometriosis involving the area of the left sciatic notch. (orig.)

  6. VIEWS OF ROMANIAN ECONOMISTS ON THE CYCLICAL FLUCTUATIONS IN ECONOMY

    Directory of Open Access Journals (Sweden)

    Pitorac Ruxandra

    2013-07-01

    Full Text Available As part of a larger work, the objective of this article is to identify the Romanian economists concerned with the study of economic crisis and cyclical fluctuations and to critically and theoretically review the Romanian literature on this subject. The research is a qualitative one and it is based upon the studying of the specialized intern literature, the tools for this research were analysis and synthesis. The study of the Romanian economic thought, concerned with explaining the causes of cyclical fluctuations, has a special importance in understanding the economic system, in general, and in taking the right measures in mitigating the fluctuations and in economic recovery after a crisis period, in particular. The starting point of the theories regarding the cyclical fluctuations in Romania is 1929, when the economic crisis broke out, with serious effects on the development of Romania. An extensive literature has been written on the economic crisis of 1929-1933, in which Romanian economists exposed their views on the causes that generated it and the solutions to get out of that state. The same thing happened during the crisis in 2008-2010. When its effects were felt in Romania, the national economists tried to explain the causes of economic crisis, as well as finding ways of recovery for the Romanian economy. The research reveals the fact that all the analyzed theories, regardless of the historical period, considered the causes of cyclical fluctuation, in general, and the causes of economic crises, in particular, as being endogenous. (technical progress, investment, consumption, production variation, overcapitalization The presentation of the economists who were concerned by this research is not exhaustive but selective and the most representative were elected to the matter under discussion, based upon the impact of their research on the economic fluctuation theories. It is necessary to take into account the nature of the economic and social

  7. Nodular cast iron fatigue lifetime in cyclic plane bending

    Directory of Open Access Journals (Sweden)

    Marian Kokavec

    2012-05-01

    Full Text Available The fatigue behavior of a component is strongly dependent on the material and its surface condition. Therefore, the manner in which the surface is prepared during component manufacturing (surface roughness, residual stresses etc. has a decisive role in dictating the initiation time for fatigue cracks. The fatigue behavior of the same material, a nodular cast iron, with three different surface conditions (fine ground, sand blast and as-cast has been investigated under cyclic plane bending. The results show differences in fatigue strength, which are associated with the surface conditions. The characteristics of the surface layers of the different test specimens were examined by metallography.

  8. Micromechanical studies of cyclic creep fracture under stress controlled loading

    DEFF Research Database (Denmark)

    van der Giessen, Erik; Tvergaard, Viggo

    1996-01-01

    This paper deals with a study of intergranular failure by creep cavitation under stress-controlled cyclic loading conditions. Loading is assumed to be slow enough that diffusion and creep mechanisms (including grain boundary sliding) dominate, leading to intergranular creep fracture. This study...... case with a facet-site microcrack yields important insight for damage accumulation under balanced loading. Under unbalanced loading, the time-average accumulation of creep cavitation gives rise to macroscopic ratchetting, while its rate is demonstrated to depend subtly on material and loading...

  9. Hygromechanical behaviour of CFRP under cyclic humidity loadings

    CERN Document Server

    Hauviller, Claude

    2001-01-01

    Stable lightweight structures are key issues in the design and construction of the LHC high precision particle detectors. This paper presents the results of long term measurements performed on plates manufactured in Carbon Fibre Reinforced Plastics (CFRP), material selected for these structures, subjected to cyclic humidity loadings. Test procedures are detailed; results on moisture absorption are described together with the related displacement measurements. These results indicate that cycling composites in the operating conditions of the LHC trackers does not provoke any major internal damage.

  10. Cyclical Upgrading of Labor and Employment Differences across Skill Groups

    OpenAIRE

    Andri Chassamboulli

    2010-01-01

    This paper examines the cyclical properties of employment rates in a search and matching model that features heterogeneous workers and jobs. Firms can create vacancies for jobs that that require either a high- or a low-skill level. High-skill workers are best suited for high-skill jobs, but are also qualified for low-skill jobs, whereas low-skill workers are only qualified for low-skill jobs. My analysis highlights the importance of a vertical type of transitory skill-mismatch, which takes th...

  11. Cyclical features of the ISAE business services series

    OpenAIRE

    Bianca Maria Martelli; Gaia Rocchetti

    2007-01-01

    The paper presents some first analysis on the ISAE Market Service Survey Series, focusing on the subset referring to Business Services (BS). The aim of the work is to identify the cyclical characteristics of BS series in order to build a confidence indicator that, in our plan, would improve the forecasts on economic fluctuations. To this end, ISAE BS series are rebuilt by merging the quarterly information collected from 1992 Q1 to 2002 Q4, with those collected on a monthly basis since January...

  12. Cyclic Competition and Percolation in Grouping Predator-Prey Populations

    Directory of Open Access Journals (Sweden)

    Alessandra F. Lütz

    2017-02-01

    Full Text Available We study, within the framework of game theory, the properties of a spatially distributed population of both predators and preys that may hunt or defend themselves either isolatedly or in group. Specifically, we show that the properties of the spatial Lett-Auger-Gaillard model, when different strategies coexist, can be understood through the geometric behavior of clusters involving four effective strategies competing cyclically,without neutral states. Moreover, the existence of strong finite-size effects, a form of the survival of the weakest effect, is related to a percolation crossover. These results may be generic and of relevance to other bimatrix games.

  13. Synthesis, conformational analysis, and biological activities of cyclic enkephalins and model cyclic peptides containing thioamides as amide bond replacements

    Energy Technology Data Exchange (ETDEWEB)

    Sherman, D.B.

    1988-01-01

    This thesis describes the first applications of the thioamide surrogate ({psi}(CSNH)) in model cyclic peptides and cyclic enkephalins. The solution phase synthesis and conformational analysis of two model cyclic endothiopentapeptides, cyclo(D-Phe-Pro{psi} (CSNH)Gly-Pro-Gly) (I) and cyclo(D-Phe-Pro-Gly-Pro{psi}(CSNH)Gly) (II), are reported. The conformations of I and II were analyzed using several 1 and 2D NMR techniques, such as INDOR, temperature and concentration dependence, {sup 1}H-{sup 1}H and {sup 1}H-{sup 13}C COSY, ROESY, and magnetization transfer. Compound I displayed the same general conformation as its parent in CDCl{sub 3}, but the {gamma}-turn hydrogen bond appeared to be weaker, while the {beta}-turn hydrogen bond appeared to be stronger. In DMSO-d{sub 6}, this molecule existed in two conformations in a ratio of 2:1. The major conformer appeared to be the same as that in CDCl{sub 3}, while the second contained at least one cis X-Pro bond, most likely at the Gly{sup 1}-Pro{sup 2} position. Compound II displayed the same conformation as its parent in both solvents. The {gamma}-turn hydrogen bond again appeared to be weaker in CDCl{sub 3}, but comparable with the parent in DMSO-d{sub 6}. Molecular modeling studies of I and II indicated the Pro {psi} angle increased by {approx}6{degree} when a thiocarbonyl was present, thereby reducing steric interactions with the Pro {beta} methylene.

  14. Physiological Functions of Cyclic Electron Transport Around Photosystem I in Sustaining Photosynthesis and Plant Growth.

    Science.gov (United States)

    Yamori, Wataru; Shikanai, Toshiharu

    2016-04-29

    The light reactions in photosynthesis drive both linear and cyclic electron transport around photosystem I (PSI). Linear electron transport generates both ATP and NADPH, whereas PSI cyclic electron transport produces ATP without producing NADPH. PSI cyclic electron transport is thought to be essential for balancing the ATP/NADPH production ratio and for protecting both photosystems from damage caused by stromal overreduction. Two distinct pathways of cyclic electron transport have been proposed in angiosperms: a major pathway that depends on the PROTON GRADIENT REGULATION 5 (PGR5) and PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE 1 (PGRL1) proteins, which are the target site of antimycin A, and a minor pathway mediated by the chloroplast NADH dehydrogenase-like (NDH) complex. Recently, the regulation of PSI cyclic electron transport has been recognized as essential for photosynthesis and plant growth. In this review, we summarize the possible functions and importance of the two pathways of PSI cyclic electron transport.

  15. Dietary Habits of Young Athletes Going in for Cyclic Sports

    Directory of Open Access Journals (Sweden)

    S. G. Makarova

    2015-01-01

    Full Text Available In modern sports, outlining an adequate diet is one of the key issues in training young athletes. The following literature review presents new approaches to nutrition of young athletes going in for cyclic sports. These sports take a lot of energy, entail great strain and significant intensity of training. Correspondingly, the ratio of nutrients in athletes training for endurance tends to shift toward carbohydrates, the amount of which in the body should cover the increased need for workload as may be defined by the training process and the amount of workload. High-fat diets have proved irrelevant in terms of providing energy function; therefore, this nutritive approach was dismissed, since an athlete should have an about 25% share of fats of his/her menu’s total caloric value. According to modern standards, the amount of proteins in athletes’ menu should not exceed 1.2–1.6g per 1kg of body weight. To avoid the risk of dehydration and physical weakness, cyclic athletes should take sport drinks (in small portions prior to and following a training session (competition. They contain carbohydrates and electrolytes and therefore are more preferable than pure water. 

  16. Thermodynamic Analysis of Closed Steady or Cyclic Systems

    Directory of Open Access Journals (Sweden)

    Jim McGovern

    2015-09-01

    Full Text Available Closed, steady or cyclic thermodynamic systems, which have temperature variations over their boundaries, can represent an extremely large range of plants, devices or natural objects, such as combined heating, cooling and power plants, computers and data centres, and planets. Energy transfer rates can occur across the boundary, which are characterized as heat or work. We focus on the finite time thermodynamics aspects, on energy-based performance parameters, on rational efficiency and on the environmental reference temperature. To do this, we examine the net work rate of a closed, steady or cyclic system bounded by thermal resistances linked to isothermal reservoirs in terms of the first and second laws of thermodynamics. Citing relevant references from the literature, we propose a methodology that can improve the thermodynamic analysis of an energy-transforming or an exergy-destroying plant. Through the reflections and analysis presented, we have found an explanation of the second law that clarifies the link between the Clausius integral of heat over temperature and the reference temperature of the Gouy–Stodola theorem. With this insight and approach, the specification of the environmental reference temperature in exergy analysis becomes more solid. We have explained the relationship between the Curzon Ahlborn heat engine and an irreversible Carnot heat engine. We have outlined the nature of subsystem rational efficiencies and have found Rant’s anergy to play an important role. We postulate that heat transfer through thermal resistance is the sole basis of irreversibility.

  17. Cyclic stretching of soft substrates induces spreading and growth

    Science.gov (United States)

    Cui, Yidan; Hameed, Feroz M.; Yang, Bo; Lee, Kyunghee; Pan, Catherine Qiurong; Park, Sungsu; Sheetz, Michael

    2015-01-01

    In the body, soft tissues often undergo cycles of stretching and relaxation that may affect cell behaviour without changing matrix rigidity. To determine whether transient forces can substitute for a rigid matrix, we stretched soft pillar arrays. Surprisingly, 1–5% cyclic stretching over a frequency range of 0.01–10 Hz caused spreading and stress fibre formation (optimum 0.1 Hz) that persisted after 4 h of stretching. Similarly, stretching increased cell growth rates on soft pillars comparative to rigid substrates. Of possible factors linked to fibroblast growth, MRTF-A (myocardin-related transcription factor-A) moved to the nucleus in 2 h of cyclic stretching and reversed on cessation; but YAP (Yes-associated protein) moved much later. Knockdown of either MRTF-A or YAP blocked stretch-dependent growth. Thus, we suggest that the repeated pulling from a soft matrix can substitute for a stiff matrix in stimulating spreading, stress fibre formation and growth. PMID:25704457

  18. Batch distillation employing cyclic rectification and stripping operations.

    Science.gov (United States)

    Flodman, Hunter R; Timm, Delmar C

    2012-05-01

    Several strategies have been proposed to increase the operating efficiency of batch distillation. In this study, conventional batch rectification and inverted batch stripping are used cyclically to promote high product flow rates for a binary fractionation. Process controls are implemented to maintain constant product purity specifications by varying the slope of the operating line. While rectifying, the light component is removed as distillate, concentrating the heavy component in the reboiler. As a result, the distillate rate decreases with time. The column is then changed from rectification to stripping modes, and the heavy component is removed as bottoms product, concentrating the light component in the distillate drum. This causes the bottoms rate to diminish with time, and the column is once again converted back to rectifying mode. Cyclic operation, transitioning from batch rectifying to stripping back to rectifying, continues until all of the initial charge is fractionated or is combined with a new charge. The fractionation of ethanol and 1-propanol using the proposed operating strategy is shown to provide several advantages including energy and time savings when compared to conventional batch or inverted batch distillation alone. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

  19. Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols.

    Science.gov (United States)

    Opoku-Temeng, Clement; Sintim, Herman O

    2016-05-06

    Cyclic di-AMP has emerged as an important signaling molecule that controls a myriad of functions, including cell wall homeostasis in different bacteria. Polyphenols display various biological activities and tea polyphenols in particular have been shown to possess among other properties antioxidant and antibacterial activities. Certain tea polyphenols, such as catechin and epigallocatechin gallate, have been used to augment the action of traditional antibiotics that target the cell wall. Considering the expanding role played by cyclic dinucleotides in bacteria, we investigated whether the action of polyphenols on bacteria could be due in part to modulation of c-di-AMP signaling. Out of 14 tested polyphenols, tannic acid (TA), theaflavin-3'-gallate (TF2B) and theaflavin-3,3'-digallate (TF3) exhibited inhibitory effects on B. subtilis c-di-AMP synthase, DisA. TF2B and TF3 specifically inhibited DisA but not YybT (a PDE) whilst TA was more promiscuous and inhibited both DisA and YybT.

  20. Cyclic AMP phosphodiesterase activity in human gingival carcinoma.

    Science.gov (United States)

    Spoto, Giuseppe; Fioroni, Massimiliano; Rubini, Corrado; Di Nicola, Maurizio; Di Pietrantonio, Francesco; Di Matteo, Elisabetta; Piattelli, Adriano

    2004-05-01

    The phosphodiesterases (PDEs) are responsible for the hydrolysis of the second messengers, cyclic AMP (cAMP) and cyclic GMP (cGMP), to their corresponding monophosphates with a fundamental role in the transduction of the intracellular signals. At least 11 different enzymatic isoforms have been identified, which are listed according to their specificity or affinity for the substratum, identity of the amino acid sequence, cofactor, and inhibitor sensitivity. Variations in PDE activity have been found in different pathologies, and they have also been correlated to different pathological e/o physiological mechanisms, such as cellular differentiation, apoptosis, and tumor invasivity. In this study, we have evaluated cAMP PDE activity in patients with carcinoma of the gingiva, with the purpose of correlating differences in its development and progression. The same enzymatic activity has been used to evaluate differences between patients with lymph node involvement (group N(+)), and patients without lymph node involvement (N(-)). The analysis of PDE activity and the cAMP assay was performed by reverse-phase HPLC on samples of fresh or frozen gingival tissues. Analysis of cAMP was confirmed with the enzyme-linked immunoabsorption assay (EIA). The differences between control and N(-) groups (P = 0.0433), and between control and N(+) groups (P = 0.0156) were statistically significant. PDE3A was also evaluated immunohistochemically in lymph-node negative and lymph-node positive cases. The differences between the two groups were statistically significant (P = 0.0397).